BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q940H6 (362 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3ZUT-A nrPDB 751 0.0 3UDB-A nrPDB 648 0.0 3UC3-A nrPDB 592 e-170 5WAX-A nrPDB 585 e-167 4CZT-A nrPDB 216 9e-57 3H4J-B nrPDB 211 6e-55 4CFF-A nrPDB 205 2e-53 5EZV-A nrPDB 203 8e-53 4D28-A nrPDB 201 3e-52 2YZA-A nrPDB 201 4e-52 4CFH-A nrPDB 201 6e-52 4RED-A nrPDB 201 6e-52 4REW-A nrPDB 200 8e-52 5ES1-A nrPDB 193 1e-49 2QNJ-A nrPDB 193 1e-49 5KZ7-A nrPDB 193 1e-49 3MN3-A nrPDB 191 6e-49 4YNZ-A nrPDB 188 3e-48 2HAK-A nrPDB 185 3e-47 6C9D-A nrPDB 184 6e-47 5YKS-A nrPDB 179 1e-45 3HZT-A nrPDB 169 2e-42 3DXN-A nrPDB 169 2e-42 4CQG-A nrPDB 167 8e-42 4D2V-A nrPDB 164 6e-41 2J90-A nrPDB 160 1e-39 2W4O-A nrPDB 159 2e-39 3F3Z-A nrPDB 158 4e-39 5JN2-A nrPDB 157 7e-39 3GUB-A nrPDB 157 8e-39 3NCG-A nrPDB 155 2e-38 3MA6-A nrPDB 155 4e-38 2BRG-A nrPDB 154 5e-38 2JC6-A nrPDB 154 8e-38 4FG9-A nrPDB 153 1e-37 3BHH-A nrPDB 153 1e-37 6CMJ-A nrPDB 153 1e-37 4UZD-A nrPDB 153 1e-37 5FG8-A nrPDB 152 2e-37 3DFA-A nrPDB 152 2e-37 5U6Y-A nrPDB 152 2e-37 3KN6-A nrPDB 152 2e-37 2VN9-A nrPDB 152 2e-37 2VZ6-A nrPDB 152 3e-37 3Q5I-A nrPDB 151 5e-37 5IG1-A nrPDB 150 7e-37 3D2K-A nrPDB 150 1e-36 3SOA-A nrPDB 149 3e-36 4RGJ-A nrPDB 148 4e-36 3LIJ-A nrPDB 147 5e-36 4MVF-A nrPDB 147 5e-36 2V7O-A nrPDB 147 9e-36 2JAM-A nrPDB 145 2e-35 2BDW-A nrPDB 145 4e-35 5YV8-A nrPDB 145 4e-35 3KK8-A nrPDB 144 6e-35 1ZWS-A nrPDB 144 8e-35 4YZB-A nrPDB 144 9e-35 2YAB-A nrPDB 143 1e-34 4B8L-A nrPDB 143 1e-34 2JDO-A nrPDB 142 2e-34 6FDY-U nrPDB 141 5e-34 5N23-A nrPDB 140 7e-34 5JZN-A nrPDB 140 8e-34 3MV5-A nrPDB 139 1e-33 2A27-A nrPDB 139 2e-33 5KCV-A nrPDB 139 2e-33 5D9K-A nrPDB 139 2e-33 5X3F-B nrPDB 138 3e-33 5F9E-A nrPDB 137 5e-33 1FOT-A nrPDB 137 8e-33 4WB7-A nrPDB 136 1e-32 3HDN-A nrPDB 135 2e-32 4I6B-A nrPDB 134 5e-32 1KOA-A nrPDB 134 6e-32 3IS5-A nrPDB 134 6e-32 3UTO-A nrPDB 134 6e-32 2X4F-A nrPDB 134 8e-32 3TXO-A nrPDB 133 1e-31 2Z7Q-A nrPDB 133 1e-31 4JG6-A nrPDB 132 2e-31 2YCR-A nrPDB 131 4e-31 4NIF-A nrPDB 131 4e-31 3DB8-A nrPDB 131 5e-31 5XZW-A nrPDB 131 6e-31 1NY3-A nrPDB 130 6e-31 2OZA-A nrPDB 130 8e-31 3KA0-A nrPDB 130 1e-30 6CCF-A nrPDB 130 1e-30 5DYK-A nrPDB 130 1e-30 4AF3-A nrPDB 129 2e-30 3I6U-A nrPDB 128 4e-30 4B6L-A nrPDB 127 5e-30 3TAC-A nrPDB 127 5e-30 2OU7-A nrPDB 127 8e-30 4J52-A nrPDB 127 1e-29 4PDS-A nrPDB 127 1e-29 4C0T-A nrPDB 125 2e-29 2I0E-A nrPDB 125 3e-29 4RA4-A nrPDB 125 4e-29 5FET-A nrPDB 124 5e-29 4JXF-A nrPDB 124 5e-29 3PFQ-A nrPDB 123 1e-28 1KOB-A nrPDB 122 3e-28 4APC-A nrPDB 120 1e-27 6BDL-A nrPDB 118 3e-27 4L42-A nrPDB 118 4e-27 6E9W-A nrPDB 118 5e-27 6QAU-A nrPDB 117 5e-27 1VZO-A nrPDB 117 6e-27 4RLP-A nrPDB 117 9e-27 3ORZ-A nrPDB 117 1e-26 2Y7J-A nrPDB 117 1e-26 1PHK-A nrPDB 116 1e-26 6DC0-A nrPDB 116 2e-26 4WNO-A nrPDB 116 2e-26 5CEK-A nrPDB 116 2e-26 3HKO-A nrPDB 115 3e-26 3A8W-A nrPDB 114 5e-26 2WTK-C nrPDB 114 6e-26 3FXW-A nrPDB 113 1e-25 6ED6-A nrPDB 113 2e-25 4XBR-A nrPDB 112 2e-25 2Q0N-A nrPDB 112 3e-25 4KS7-A nrPDB 112 3e-25 4JDH-A nrPDB 112 3e-25 4FIE-A nrPDB 112 4e-25 3LM0-A nrPDB 111 6e-25 6E2O-A nrPDB 110 1e-24 4EQM-A nrPDB 109 2e-24 3DLS-A nrPDB 108 3e-24 4X7Q-B nrPDB 107 6e-24 4CRS-A nrPDB 107 8e-24 4RC3-A nrPDB 106 2e-23 5TUR-A nrPDB 106 2e-23 3BGP-A nrPDB 105 2e-23 4OTD-A nrPDB 104 5e-23 5LOH-A nrPDB 103 1e-22 3M42-A nrPDB 103 1e-22 6BXI-A nrPDB 103 2e-22 4BGQ-A nrPDB 103 2e-22 2BPM-A nrPDB 102 2e-22 6GU6-A nrPDB 102 3e-22 3Q53-A nrPDB 101 5e-22 1TKI-A nrPDB 100 7e-22 2F57-A nrPDB 100 7e-22 3GC0-A nrPDB 100 1e-21 5J5T-A nrPDB 100 1e-21 4AU8-A nrPDB 100 1e-21 6FD3-A nrPDB 100 1e-21 6CQF-A nrPDB 100 2e-21 2XNP-A nrPDB 100 2e-21 4UYA-A nrPDB 99 3e-21 3PPZ-A nrPDB 99 4e-21 2HW6-A nrPDB 98 5e-21 1U5R-A nrPDB 98 5e-21 2GCD-A nrPDB 98 5e-21 3DAK-A nrPDB 98 7e-21 5UUU-A nrPDB 98 7e-21 2UV2-A nrPDB 97 7e-21 3TKU-A nrPDB 97 8e-21 3PVW-A nrPDB 97 1e-20 3NIZ-A nrPDB 97 1e-20 6CKI-A nrPDB 96 2e-20 4IDT-A nrPDB 95 4e-20 5L2Q-C nrPDB 95 4e-20 3C51-A nrPDB 95 4e-20 4GS6-A nrPDB 95 5e-20 3COM-A nrPDB 95 6e-20 1V0B-A nrPDB 95 6e-20 5VO2-A nrPDB 94 6e-20 4G3E-A nrPDB 94 7e-20 5KKR-C nrPDB 94 7e-20 4UY9-A nrPDB 94 9e-20 3QA8-A nrPDB 94 1e-19 3EQC-A nrPDB 94 1e-19 4AN9-A nrPDB 92 3e-19 4FR4-A nrPDB 92 3e-19 1S9I-A nrPDB 92 3e-19 3DTC-A nrPDB 92 3e-19 4QMW-A nrPDB 92 5e-19 4KIK-B nrPDB 91 7e-19 5DBX-A nrPDB 91 8e-19 4AGU-A nrPDB 91 8e-19 4NST-A nrPDB 91 9e-19 4BBM-A nrPDB 91 1e-18 4LG4-A nrPDB 91 1e-18 6AO5-A nrPDB 91 1e-18 5X5O-A nrPDB 90 1e-18 4AW2-A nrPDB 90 1e-18 2XIK-A nrPDB 90 2e-18 3ZDU-A nrPDB 90 2e-18 4FZF-B nrPDB 89 2e-18 4KRC-A nrPDB 89 2e-18 2VD5-A nrPDB 89 3e-18 6DTL-A nrPDB 89 3e-18 1UA2-A nrPDB 89 3e-18 5EFQ-A nrPDB 89 4e-18 6HXF-B nrPDB 88 6e-18 5AIR-A nrPDB 88 7e-18 4U41-A nrPDB 87 1e-17 4IC8-A nrPDB 87 1e-17 2WQN-A nrPDB 87 1e-17 4ZSG-A nrPDB 87 1e-17 5D7A-A nrPDB 87 1e-17 2F9G-A nrPDB 86 3e-17 3SXS-A nrPDB 85 4e-17 5TQX-A nrPDB 85 4e-17 5G6V-A nrPDB 85 6e-17 3NYO-A nrPDB 84 9e-17 1CM8-A nrPDB 84 1e-16 4PWN-A nrPDB 83 2e-16 3OHT-A nrPDB 83 2e-16 4EWQ-A nrPDB 83 2e-16 3ORP-A nrPDB 83 2e-16 3E7O-A nrPDB 83 2e-16 4TNB-A nrPDB 83 2e-16 2BUJ-A nrPDB 82 4e-16 4MYG-A nrPDB 82 5e-16 4F0G-A nrPDB 81 6e-16 5Z33-A nrPDB 80 1e-15 3E3P-A nrPDB 80 1e-15 4QNY-A nrPDB 80 1e-15 6DBM-A nrPDB 80 1e-15 5O0Y-A nrPDB 80 1e-15 2XS0-A nrPDB 80 2e-15 5HVK-A nrPDB 80 2e-15 1JNK-A nrPDB 79 2e-15 5O2C-A nrPDB 79 2e-15 3FI2-A nrPDB 79 2e-15 5O2B-A nrPDB 79 3e-15 1ZXE-A nrPDB 79 3e-15 4TPT-A nrPDB 79 3e-15 3OMV-A nrPDB 79 3e-15 1G3N-A nrPDB 79 3e-15 4E7W-A nrPDB 79 4e-15 5NGU-A nrPDB 79 4e-15 4QTB-A nrPDB 78 5e-15 2Y4I-B nrPDB 78 7e-15 5AWM-A nrPDB 78 7e-15 2I6L-A nrPDB 77 8e-15 4Y83-A nrPDB 77 9e-15 3MIA-A nrPDB 77 1e-14 4C59-A nrPDB 77 2e-14 6DBN-A nrPDB 75 4e-14 4OLI-A nrPDB 75 5e-14 2W96-B nrPDB 75 5e-14 2W1I-A nrPDB 75 6e-14 3QGY-A nrPDB 75 6e-14 2Y6O-A nrPDB 74 1e-13 3GC9-A nrPDB 74 1e-13 4E20-A nrPDB 73 1e-13 5B2L-A nrPDB 73 2e-13 3IO7-A nrPDB 73 2e-13 2VWV-A nrPDB 73 2e-13 4YHJ-A nrPDB 73 2e-13 3EB0-A nrPDB 73 2e-13 6O6Q-A nrPDB 73 2e-13 3VN9-A nrPDB 72 3e-13 4P5Q-A nrPDB 72 3e-13 3FME-A nrPDB 72 3e-13 6E4F-A nrPDB 72 3e-13 5ZTN-A nrPDB 72 4e-13 4XI2-A nrPDB 72 4e-13 5Y86-A nrPDB 72 4e-13 3NIE-A nrPDB 72 4e-13 4JLC-A nrPDB 72 4e-13 4HZS-A nrPDB 72 6e-13 4Y93-A nrPDB 71 6e-13 4CRL-A nrPDB 71 7e-13 3KUL-B nrPDB 71 7e-13 4O2Z-A nrPDB 71 8e-13 3N9X-A nrPDB 71 9e-13 5HI2-A nrPDB 71 9e-13 4OW8-A nrPDB 71 9e-13 6B2Q-A nrPDB 70 1e-12 1U54-B nrPDB 70 1e-12 4EUT-A nrPDB 70 1e-12 6NT9-A nrPDB 70 1e-12 5HIE-A nrPDB 70 1e-12 4EUU-A nrPDB 70 1e-12 3OZ6-A nrPDB 70 1e-12 4X3F-A nrPDB 70 1e-12 3HMP-A nrPDB 70 1e-12 4YFF-A nrPDB 70 1e-12 5L6P-A nrPDB 70 1e-12 6GVJ-A nrPDB 70 2e-12 4E93-A nrPDB 70 2e-12 4CSV-A nrPDB 69 2e-12 3RP9-A nrPDB 69 3e-12 2WO6-A nrPDB 69 3e-12 5AP3-A nrPDB 69 3e-12 3ALO-A nrPDB 69 4e-12 2WTK-B nrPDB 69 4e-12 6O8B-A nrPDB 69 5e-12 5X8I-B nrPDB 68 6e-12 3PLS-A nrPDB 68 6e-12 5UIU-A nrPDB 67 8e-12 2ZMD-A nrPDB 67 9e-12 3DKO-A nrPDB 67 9e-12 4PDO-A nrPDB 67 9e-12 2R2P-A nrPDB 67 1e-11 4HVI-A nrPDB 67 2e-11 4LFI-A nrPDB 67 2e-11 1U59-A nrPDB 67 2e-11 1JPA-A nrPDB 67 2e-11 5TE0-A nrPDB 66 2e-11 5AMN-A nrPDB 66 2e-11 4LQP-A nrPDB 66 2e-11 2PMN-X nrPDB 66 2e-11 4IAN-A nrPDB 65 6e-11 2XYN-A nrPDB 65 6e-11 2JD5-A nrPDB 64 8e-11 2OZO-A nrPDB 64 8e-11 5H2U-A nrPDB 64 9e-11 6HV0-A nrPDB 64 1e-10 5VC6-A nrPDB 63 2e-10 5IKW-A nrPDB 63 2e-10 5XVU-A nrPDB 62 3e-10 5MJB-A nrPDB 62 3e-10 6EII-A nrPDB 62 4e-10 3A4O-X nrPDB 62 5e-10 5UNP-A nrPDB 62 5e-10 5WNO-A nrPDB 62 6e-10 4MD7-E nrPDB 61 7e-10 5VD3-A nrPDB 61 9e-10 2RIO-A nrPDB 60 2e-09 6NPU-A nrPDB 60 2e-09 5FM2-A nrPDB 60 2e-09 6CTH-A nrPDB 60 2e-09 4M7I-A nrPDB 60 2e-09 3PP0-A nrPDB 60 2e-09 4AT3-A nrPDB 60 2e-09 4XEY-B nrPDB 60 2e-09 6HMD-A nrPDB 59 3e-09 4NEU-A nrPDB 59 3e-09 4M66-A nrPDB 59 3e-09 2FO0-A nrPDB 59 3e-09 2A1A-B nrPDB 59 4e-09 4XCU-A nrPDB 58 6e-09 4PL5-B nrPDB 57 1e-08 1AD5-A nrPDB 57 1e-08 3RAW-A nrPDB 57 1e-08 3LLT-A nrPDB 57 1e-08 2DQ7-X nrPDB 57 1e-08 2PSQ-A nrPDB 57 2e-08 4K33-A nrPDB 57 2e-08 4WUA-A nrPDB 57 2e-08 5KMM-A nrPDB 56 2e-08 5U6B-A nrPDB 56 2e-08 3UIU-A nrPDB 56 2e-08 6FER-A nrPDB 56 3e-08 5E8V-A nrPDB 56 3e-08 2HK5-A nrPDB 55 3e-08 1PY5-A nrPDB 55 3e-08 3REP-A nrPDB 55 4e-08 6FEX-A nrPDB 55 5e-08 3BBT-B nrPDB 54 1e-07 3Q4U-A nrPDB 54 1e-07 2X7G-A nrPDB 54 1e-07 1LUF-A nrPDB 54 1e-07 5SYS-A nrPDB 54 1e-07 3PG1-A nrPDB 54 2e-07 3LMG-A nrPDB 54 2e-07 5AR8-A nrPDB 53 2e-07 2C47-A nrPDB 53 2e-07 5EG3-A nrPDB 53 2e-07 2QKW-B nrPDB 53 2e-07 2PL0-A nrPDB 52 3e-07 3MDY-A nrPDB 52 3e-07 2PVN-A nrPDB 52 3e-07 5HLW-A nrPDB 52 3e-07 5OAT-A nrPDB 52 3e-07 4NT4-A nrPDB 52 3e-07 5LPZ-A nrPDB 52 3e-07 5TOS-A nrPDB 52 3e-07 4F9B-A nrPDB 52 3e-07 2H34-A nrPDB 52 4e-07 5LPV-A nrPDB 52 4e-07 6FYV-A nrPDB 52 4e-07 2H8H-A nrPDB 52 4e-07 3SV0-A nrPDB 52 4e-07 2CHL-A nrPDB 52 5e-07 6BSD-A nrPDB 51 7e-07 3GQL-A nrPDB 51 7e-07 3C1X-A nrPDB 51 8e-07 6F3F-A nrPDB 51 8e-07 3TT0-A nrPDB 51 9e-07 3V5Q-A nrPDB 50 1e-06 5A46-A nrPDB 50 1e-06 1FVR-A nrPDB 50 2e-06 5GNK-A nrPDB 50 2e-06 3QUP-A nrPDB 50 2e-06 2CMW-A nrPDB 50 2e-06 3ZBF-A nrPDB 50 2e-06 3MY0-A nrPDB 50 2e-06 5C26-A nrPDB 50 2e-06 5VDK-A nrPDB 49 4e-06 4FL3-A nrPDB 48 5e-06 3UIM-A nrPDB 48 6e-06 3LZB-A nrPDB 47 1e-05 5M07-A nrPDB 47 1e-05 5XD6-A nrPDB 47 2e-05 3ZZW-A nrPDB 46 2e-05 4TN6-A nrPDB 46 2e-05 4BTK-A nrPDB 45 4e-05 4NFN-A nrPDB 45 4e-05 4LRM-A nrPDB 45 5e-05 5X1R-A nrPDB 45 5e-05 5J0A-A nrPDB 44 8e-05 1CSN-A nrPDB 44 8e-05 2PZI-A nrPDB 44 9e-05 5FQD-C nrPDB 44 1e-04 2QLU-A nrPDB 44 1e-04 4Y12-A nrPDB 44 1e-04 5X18-A nrPDB 44 1e-04 4MWI-A nrPDB 44 1e-04 3AOX-A nrPDB 43 2e-04 3SOC-A nrPDB 43 2e-04 3QD2-B nrPDB 42 4e-04 6J5U-C nrPDB 42 6e-04 4L00-A nrPDB 41 7e-04 6BFN-A nrPDB 41 8e-04 4XHL-A nrPDB 41 0.001 5CLR-A nrPDB 40 0.001 4XHH-A nrPDB 40 0.001 4JRN-A nrPDB 40 0.001 6EQI-C nrPDB 38 0.005 6EWX-A nrPDB 37 0.009 3G2F-A nrPDB 36 0.020 6BHC-A nrPDB 36 0.031 5UU1-A nrPDB 35 0.048 5VE6-A nrPDB 33 0.26 2GLJ-A nrPDB 32 0.34 5UV4-A nrPDB 32 0.37 6G4J-A nrPDB 32 0.38 2RSV-A nrPDB 29 2.9 2LAV-A nrPDB 29 2.9 5XU1-M nrPDB 29 3.2 >3ZUT-A nrPDB Length = 362 Score = 751 bits (1938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/362 (99%), Positives = 361/362 (99%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE Sbjct: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF Sbjct: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC FGYSKSSVLHSQPKSTVGTP Sbjct: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTP 180 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ Sbjct: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 Query: 301 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY 360 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY Sbjct: 301 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY 360 Query: 361 AM 362 AM Sbjct: 361 AM 362 >3UDB-A nrPDB Length = 317 Score = 648 bits (1672), Expect = 0.0, Method: Compositional matrix adjust. Identities = 309/317 (97%), Positives = 313/317 (98%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 MDRPAV+GPMDLPIMHDSDRYELVKDIG+GNFGVARLMRDKQ+NELVAVKYIERGEKIDE Sbjct: 1 MDRPAVAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF Sbjct: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 FQQLISGVSY HAMQV HRDLKLENTLLDGSPAPRLKI DFGYSK+SVLHSQPKS VGTP Sbjct: 121 FQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTP 180 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ Sbjct: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 Query: 301 PGQSIEEIMQIIAEATV 317 PGQSIEEIMQIIAEATV Sbjct: 301 PGQSIEEIMQIIAEATV 317 >3UC3-A nrPDB Length = 361 Score = 592 bits (1526), Expect = e-170, Method: Compositional matrix adjust. Identities = 286/363 (78%), Positives = 327/363 (90%), Gaps = 3/363 (0%) Query: 1 MDR-PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 MDR P +GP+D+PIMHDSDRY+ VKDIGSGNFGVARLMRDK + ELVAVKYIERG ID Sbjct: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID 60 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 FFQQL+SGVSYCH+MQ+CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT Sbjct: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 Query: 300 QPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIV 359 QP QS++ IMQII+EAT+P + L+ ++T +LD+DDDM++ ++DIDSSGEIV Sbjct: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSE--SEIDIDSSGEIV 358 Query: 360 YAM 362 YA+ Sbjct: 359 YAL 361 >5WAX-A nrPDB Length = 310 Score = 585 bits (1507), Expect = e-167, Method: Compositional matrix adjust. Identities = 273/309 (88%), Positives = 296/309 (95%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 MD+PIMHD DRYELV+DIGSGNFGVARLMR++ +LVAVKYIERGEKIDENV+REIINH Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINH 61 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 RSLRHPNI+RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS Sbjct: 62 RSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 YCH+MQVCHRDLKLENTLLDGS APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDP+EPKNFRKTI RIL VQY+IPDYVHISPE Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 C+ LISRIFVA+PA RI+IPEIRNH WFLKNLPADLM+D+TM+ Q++E +QP QS++EIM Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDEIM 301 Query: 310 QIIAEATVP 318 QI+AEAT+P Sbjct: 302 QILAEATIP 310 >4CZT-A nrPDB Length = 464 Score = 216 bits (551), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 114/276 (41%), Positives = 165/276 (59%), Gaps = 25/276 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-----VKREIINHRSLRH 74 +YEL + +G G F + R+ ++ + VA+K I++ EK+ +N +KREI + ++H Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK-EKVLKNKMIAQIKREISTMKLIKH 70 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PN++R EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V YCH+ Sbjct: 71 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 130 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEV 187 V HRDLK EN LLD + A LK+ DFG S + +LH +T GTP Y+APEV Sbjct: 131 GVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEV 184 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + K YDG AD+WSCGV L+V++ G PFED N +I ++ P + S Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDS----NLTSLYKKIFKAEFTCPPW--FS 238 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 + LI RI +PA RI+ E+ +EWF K A Sbjct: 239 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 274 >3H4J-B nrPDB Length = 336 Score = 211 bits (536), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 117/266 (43%), Positives = 162/266 (60%), Gaps = 13/266 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPN 76 Y + + +G G+FG +L ++ + VA+K+I R + V+REI + LRHP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I++ +VI TPT + +V+EYA GGELF+ I R +EDE R FFQQ+I + YCH ++ Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLD + +KI DFG S + K++ G+P Y APEV+ K Y G Sbjct: 130 VHRDLKPENLLLDDNL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWSCG+ LYVMLVG PF+D P F+K + + Y +PD+ +SP + LI R Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKK----VNSCVYVMPDF--LSPGAQSLIRR 241 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLP 282 + VADP +RI+I EIR WF NLP Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLP 267 >4CFF-A nrPDB Length = 571 Score = 205 bits (522), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 120/291 (41%), Positives = 160/291 (54%), Gaps = 18/291 (6%) Query: 8 GPMDLPIMHDS----DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--- 60 GPM HD Y L +G G FG ++ + + VAVK + R +KI Sbjct: 18 GPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDV 76 Query: 61 --NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR 118 +KREI N + RHP+I++ +VI TPT +VMEY SGGELF+ IC GR E EAR Sbjct: 77 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 136 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 FQQ++S V YCH V HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCG 194 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 +P Y APEV+ + Y G D+WSCGV LY +L G PF+D P F+K I + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVF 250 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDN 289 IP+Y++ S L+ + DP KR +I +IR HEWF ++LP+ L ++ Sbjct: 251 YIPEYLNRSVAT--LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 299 >5EZV-A nrPDB Length = 560 Score = 203 bits (517), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 115/271 (42%), Positives = 153/271 (56%), Gaps = 14/271 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Y L +G G FG ++ + + VAVK + R +KI +KREI N + RHP Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 89 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 148 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 149 VVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 206 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 207 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRSVAT--LLM 260 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + DP KR +I +IR HEWF ++LP+ L Sbjct: 261 HMLQVDPLKRATIKDIREHEWFKQDLPSYLF 291 >4D28-A nrPDB Length = 446 Score = 201 bits (512), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 111/277 (40%), Positives = 160/277 (57%), Gaps = 25/277 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHR 70 M +YE+ + IG G F + R+ + + VA+K + + ++ + +KREI + Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 +RHPNIVR EV+ + + + IV+E+ +GGELF+RI + GR EDE+R +FQQL+ V++ Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-------TVGTPAYI 183 CH+ V HRDLK EN LLD + LK+ DFG L + P+ T GTP Y+ Sbjct: 125 CHSKGVYHRDLKPENLLLDTN--GNLKVSDFG------LSALPQEGVELLNDTCGTPNYV 176 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 APEVL + YDG AD+WSCGV L+V+L G PF + + P +RK I ++ P + Sbjct: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFDCPPW 232 Query: 244 VHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 S E + LI RI +P RI I I+ WF KN Sbjct: 233 --FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKN 267 >2YZA-A nrPDB Length = 276 Score = 201 bits (511), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 115/271 (42%), Positives = 152/271 (56%), Gaps = 14/271 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Y L +G G FG ++ + + VAVK + R +KI +KREI N + RHP Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 131 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S + + G+P Y APEV+ + Y G Sbjct: 132 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 190 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRSVAT--LLM 243 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + DP KR +I +IR HEWF ++LP+ L Sbjct: 244 HMLQVDPLKRATIKDIREHEWFKQDLPSYLF 274 >4CFH-A nrPDB Length = 493 Score = 201 bits (510), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 116/288 (40%), Positives = 158/288 (54%), Gaps = 18/288 (6%) Query: 8 GPMDLPIMHDS----DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--- 60 GPM HD Y L +G G FG ++ + + + VAVK + R +KI Sbjct: 18 GPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR-QKIRSLDV 76 Query: 61 --NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR 118 ++REI N + RHP+I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R Sbjct: 77 VGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR 136 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 FQQ++SGV YCH V HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCG 194 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 +P Y APEV+ + Y G D+WS GV LY +L G PF+D P F+K I + + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK----ICDGIF 250 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 P Y ++P L+ + DP KR +I +IR HEWF ++LP L Sbjct: 251 YTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLF 296 >4RED-A nrPDB Length = 351 Score = 201 bits (510), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 112/271 (41%), Positives = 152/271 (56%), Gaps = 14/271 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Y L +G G FG ++ + + + VAVK + R +KI ++REI N + RHP Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNR-QKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R FQQ++SGV YCH Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 135 VVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WS GV LY +L G PF+D P F+K I + P Y ++P L+ Sbjct: 193 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQY--LNPSVISLLK 246 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + DP KR SI +IR HEWF ++LP L Sbjct: 247 HMLQVDPMKRASIKDIREHEWFKQDLPKYLF 277 >4REW-A nrPDB Length = 540 Score = 200 bits (508), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 112/271 (41%), Positives = 153/271 (56%), Gaps = 14/271 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Y L +G G FG ++ + + + VAVK + R +KI ++REI N + RHP Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR-QKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R FQQ++SGV YCH Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 127 VVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 184 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WS GV LY +L G PF+D P F+K I + + P Y ++P L+ Sbjct: 185 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKK----ICDGIFYTPQY--LNPSVISLLK 238 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + DP KR SI +IR HEWF ++LP L Sbjct: 239 HMLQVDPMKRASIKDIREHEWFKQDLPKYLF 269 >5ES1-A nrPDB Length = 328 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 102/259 (39%), Positives = 151/259 (58%), Gaps = 11/259 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPNI 77 Y L++ IG GNF +L R + VA+K I++ + +++ RE+ + L HPNI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V+ EVI T L +VMEYAS GE+F+ + + GR E EAR F+Q++S V YCH + Sbjct: 77 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV 136 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLD +KI DFG+S L S+ + G+P Y APE+ K+YDG Sbjct: 137 HRDLKAENLLLDAE--ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 D+WS GV LY ++ G+ PF+ N ++ R+L +Y +P Y +S +C ++ R Sbjct: 195 VDIWSLGVILYTLVSGSLPFDG----HNLKELRERVLRGKYRVPFY--MSTDCESILRRF 248 Query: 258 FVADPAKRISIPEIRNHEW 276 V +PAKR ++ +I +W Sbjct: 249 LVLNPAKRCTLEQIMKDKW 267 >2QNJ-A nrPDB Length = 328 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 103/259 (39%), Positives = 151/259 (58%), Gaps = 11/259 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPNI 77 Y L+K IG GNF +L R + VA+K I++ + +++ RE+ + L HPNI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V+ EVI T L ++MEYASGGE+F+ + GR E EAR F+Q++S V YCH ++ Sbjct: 74 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 133 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLD +KI DFG+S + + + G+P Y APE+ K+YDG Sbjct: 134 HRDLKAENLLLDAD--MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPE 191 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ R Sbjct: 192 VDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKRF 245 Query: 258 FVADPAKRISIPEIRNHEW 276 V +P KR ++ +I W Sbjct: 246 LVLNPIKRGTLEQIMKDRW 264 >5KZ7-A nrPDB Length = 346 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 103/259 (39%), Positives = 152/259 (58%), Gaps = 11/259 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPNI 77 Y L+K IG GNF +L R + + VAVK I++ + +++ RE+ + L HPNI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 95 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 154 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLD +KI DFG+S ++ + G+P Y APE+ K+YDG Sbjct: 155 HRDLKAENLLLDAD--MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPE 212 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ + Sbjct: 213 VDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKKF 266 Query: 258 FVADPAKRISIPEIRNHEW 276 + +P+KR ++ +I W Sbjct: 267 LILNPSKRGTLEQIMKDRW 285 >3MN3-A nrPDB Length = 271 Score = 191 bits (484), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 112/270 (41%), Positives = 154/270 (57%), Gaps = 13/270 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSLRHPN 76 Y++VK +G G+FG +L + + VA+K I + + ++REI R LRHP+ Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I++ +VI + + +V+EYA G ELF+ I + SE EAR FFQQ+IS V YCH ++ Sbjct: 66 IIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKI 124 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLD +KI DFG S + K++ G+P Y APEV+ K Y G Sbjct: 125 VHRDLKPENLLLD--EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGP 182 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWSCGV LYVML PF+D P F+ I N Y +P + +SP LI R Sbjct: 183 EVDVWSCGVILYVMLCRRLPFDDESIPVLFKN----ISNGVYTLPKF--LSPGAAGLIKR 236 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + + +P RISI EI +WF +LP L+ Sbjct: 237 MLIVNPLNRISIHEIMQDDWFKVDLPEYLL 266 >4YNZ-A nrPDB Length = 342 Score = 188 bits (478), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 100/268 (37%), Positives = 162/268 (60%), Gaps = 15/268 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV----KREIINHRSLRHPN 76 Y L K +G G G+ +L + + VA+K + R EK+ E+V +REI + + HP+ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNR-EKLSESVLMKVEREIAILKLIEHPH 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +++ +V +L +V+E+ SGGELF+ + GR + EAR FF+Q+IS + +CH+ + Sbjct: 71 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 CHRDLK EN LLD ++I DFG + V S +++ G+P Y PEV+ ++YDG+ Sbjct: 131 CHRDLKPENLLLD--ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 ADVWSCGV L+ +LVGA PF+D N R+ + ++ + +P + I P+C+ L+ Sbjct: 189 KADVWSCGVILFALLVGALPFDD----DNLRQLLEKVKRGVFHMPHF--IPPDCQSLLRG 242 Query: 257 IFVADPAKRISIPEIRNHEWFL--KNLP 282 + D A+R+++ I+ H W++ KN P Sbjct: 243 MIEVDAARRLTLEHIQKHIWYIGGKNEP 270 >2HAK-A nrPDB Length = 328 Score = 185 bits (469), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 152/259 (58%), Gaps = 11/259 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPNI 77 Y L K IG GNF +L R + VAVK I++ + +++ RE+ + L HPNI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 77 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 136 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLDG +KI DFG+S + ++ + G+P Y APE+ K+YDG Sbjct: 137 HRDLKAENLLLDGD--MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ ++ Sbjct: 195 VDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKKL 248 Query: 258 FVADPAKRISIPEIRNHEW 276 V +P KR S+ +I W Sbjct: 249 LVLNPIKRGSLEQIMKDRW 267 >6C9D-A nrPDB Length = 459 Score = 184 bits (467), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 151/259 (58%), Gaps = 11/259 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPNI 77 Y L K IG GNF +L R + VAVK I++ + +++ RE+ + L HPNI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 83 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 142 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLDG +KI DFG+S + ++ G+P Y APE+ K+YDG Sbjct: 143 HRDLKAENLLLDGD--MNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPE 200 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ ++ Sbjct: 201 VDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKKL 254 Query: 258 FVADPAKRISIPEIRNHEW 276 V +P KR S+ +I W Sbjct: 255 LVLNPIKRGSLEQIMKDRW 273 >5YKS-A nrPDB Length = 377 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 98/262 (37%), Positives = 154/262 (58%), Gaps = 13/262 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE----NVKREIINHRSLRHPN 76 Y+L K +G G+F V +L R + E VAVK I++ K+D ++ +E+ + ++HPN Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK-TKLDTLATGHLFQEVRCMKLVQHPN 95 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQ 135 IVR EVI T T L +++E GG++F+ I +ED A+ +F Q++ +SYCH + Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN + +K+ DFG+S + ++ G+ AY APE+LL EYD Sbjct: 156 VVHRDLKPENVVFFEKQG-LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WS GV L++++ G PF++ N +T+ I++ +Y +P H+S EC+ LI+ Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEA----NDSETLTMIMDCKYTVPS--HVSKECKDLIT 268 Query: 256 RIFVADPAKRISIPEIRNHEWF 277 R+ DP +R S+ EI NH W Sbjct: 269 RMLQRDPKRRASLEEIENHPWL 290 >3HZT-A nrPDB Length = 467 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 99/269 (36%), Positives = 148/269 (55%), Gaps = 13/269 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLR 73 SDRY+ VK +GSG +G L +DK + A+K I++ + +++ + L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +VME GGELF+ I +FSE +A +Q++SG +Y H Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 134 MQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 + HRDLK EN LL+ L KI DFG S + + K +GT YIAPEV L+K+ Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV-LRKK 181 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPEC 250 YD K DVWSCGV LY++L G PF + ++ + R+ +++ PD+ +S E Sbjct: 182 YDEK-CDVWSCGVILYILLCGYPPFGGQTD----QEILKRVEKGKFSFDPPDWTQVSDEA 236 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLK 279 + L+ + +P+KRIS E NH W +K Sbjct: 237 KQLVKLMLTYEPSKRISAEEALNHPWIVK 265 >3DXN-A nrPDB Length = 287 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 102/280 (36%), Positives = 152/280 (54%), Gaps = 13/280 (4%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI 66 SG +L SDRY+ VK +GSG +G L +DK + A+K I++ + + Sbjct: 9 SGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGAL 68 Query: 67 INH----RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 ++ + L HPNI++ E + +VME GGELF+ I +FSE +A + Sbjct: 69 LDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK 128 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPA 181 Q++SG +Y H + HRDLK EN LL+ L KI DFG S + + K +GT Sbjct: 129 QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY 188 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI- 240 YIAPEV L+K+YD K DVWSCGV LY++L G PF + ++ + R+ +++ Sbjct: 189 YIAPEV-LRKKYDEK-CDVWSCGVILYILLCGYPPFGGQTD----QEILKRVEKGKFSFD 242 Query: 241 -PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 PD+ +S E + L+ + +P+KRIS E NH W +K Sbjct: 243 PPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >4CQG-A nrPDB Length = 331 Score = 167 bits (422), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 102/288 (35%), Positives = 154/288 (53%), Gaps = 25/288 (8%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIV 78 YEL + IG+G F +L + E+VA+K +++ + VK EI +SLRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + V+ T + +V+EY GGELF+ I + R SE+E R F+Q++S V+Y H+ H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAH 130 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS--------TVGTPAYIAPEVLLK 190 RDLK EN L D + +LK+ DFG L ++PK G+ AY APE++ Sbjct: 131 RDLKPENLLFDEN--HKLKLIDFG------LCAKPKGNKDYHLQECCGSLAYAAPELIQG 182 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 K Y G ADVWS G+ LYV++ G PF+D N +I+ +Y +P + +SP Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDD----DNVMALYKKIMRGKYEVPKW--LSPSS 236 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLKNLPADL-MNDNTMTTQFDE 297 L+ ++ DP KRIS+ + NH W +++ + T T DE Sbjct: 237 ILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDE 284 >4D2V-A nrPDB Length = 356 Score = 164 bits (415), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 98/281 (34%), Positives = 152/281 (54%), Gaps = 26/281 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIV 78 YEL + IG+G F +L + E+VA+K +++ + +K EI ++LRH +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + V+ T + +V+EY GGELF+ I + R SE+E R F+Q++S V+Y H+ H Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK--------STVGTPAYIAPEVLLK 190 RDLK EN L D +LK+ DFG L ++PK + G AY APE++ Sbjct: 151 RDLKPENLLFD--EYHKLKLIDFG------LCAKPKGNKDYHLQACCGALAYAAPELIQG 202 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 K Y G ADVWS G+ LYV++ G PF+D + +I+ +Y +P + +SP Sbjct: 203 KSYLGSEADVWSMGILLYVLMCGFLPFDDDTAA----ALVAKIMRGKYDVPKW--LSPSS 256 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLK--NLPADLMNDN 289 L+ ++ DP KRIS+ + NH W ++ N P + + N Sbjct: 257 ILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKN 297 >2J90-A nrPDB Length = 304 Score = 160 bits (404), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 91/270 (33%), Positives = 148/270 (54%), Gaps = 18/270 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--------RGEKIDENVKREIINHR 70 D YE+ +++GSG F + R R K + + A K+I+ RG +E ++RE+ R Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE-IEREVNILR 84 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 +RHPNI+ ++ T + +++E SGGELF+ + +EDEA F +Q++ GV Y Sbjct: 85 EIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHY 144 Query: 131 CHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 H+ ++ H DLK EN +L P PR+K+ DFG + ++ K+ GTP ++APE+ Sbjct: 145 LHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEI- 203 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHI 246 + E G AD+WS GV Y++L GA PF + ++T+ I V Y + + + Sbjct: 204 VNYEPLGLEADMWSIGVITYILLSGASPFLGETK----QETLTNISAVNYDFDEEYFSNT 259 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEW 276 S + I R+ V DP +R++I + H W Sbjct: 260 SELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 >2W4O-A nrPDB Length = 349 Score = 159 bits (401), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 101/303 (33%), Positives = 161/303 (53%), Gaps = 13/303 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-EIINHRSLRHPN 76 SD +E+ ++G G + + K + + A+K +++ +D+ + R EI L HPN Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKK--TVDKKIVRTEIGVLLRLSHPN 109 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I++ KE+ TPT +++V+E +GGELF+RI G +SE +A +Q++ V+Y H + Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 137 CHRDLKLENTLLDGSPAPR--LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 HRDLK EN LL +PAP LKI DFG SK K+ GTP Y APE+L Y Sbjct: 170 VHRDLKPEN-LLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY- 227 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPECRH 252 G D+WS G+ Y++L G PF D E F RILN +Y P + +S + Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYD-ERGDQF--MFRRILNCEYYFISPWWDEVSLNAKD 284 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQII 312 L+ ++ V DP KR++ + H W + A+ ++ +T + E + + + ++ Sbjct: 285 LVRKLIVLDPKKRLTTFQALQHPW-VTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVV 343 Query: 313 AEA 315 A + Sbjct: 344 ASS 346 >3F3Z-A nrPDB Length = 277 Score = 158 bits (399), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 98/272 (36%), Positives = 144/272 (52%), Gaps = 12/272 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPNIV 78 Y L IG G++G ++ K + A K I + E +D K+EI +SL HPNI+ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD-RFKQEIEIMKSLDHPNII 69 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 R E T + +VME +GGELFER+ + F E +A + ++S V+YCH + V H Sbjct: 70 RLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 139 RDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 RDLK EN L L SP LK+ DFG + ++ VGTP Y++P+VL + G Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL--EGLYGPE 187 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHISPECRHLIS 255 D WS GV +YV+L G PF P + + + +I + P D++++SP+ LI Sbjct: 188 CDEWSAGVMMYVLLCGYPPFSAPTD----SEVMLKIREGTFTFPEKDWLNVSPQAESLIR 243 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 R+ P +RI+ + HEWF K L + N Sbjct: 244 RLLTKSPKQRITSLQALEHEWFEKQLSSSPRN 275 >5JN2-A nrPDB Length = 525 Score = 157 bits (397), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 97/264 (36%), Positives = 143/264 (54%), Gaps = 9/264 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKID-ENVKREIINHRSLR 73 SDRY+ + +G G+FG L +DK + + AVK I + +K D E++ RE+ + L Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 125 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 185 Query: 134 MQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL+ S ++I DFG S + K +GT YIAPEV L Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV-LHGT 244 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 245 YDEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG--KYTFELPQWKKVSESAKD 301 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 LI ++ P+ RIS + +HEW Sbjct: 302 LIRKMLTYVPSMRISARDALDHEW 325 >3GUB-A nrPDB Length = 295 Score = 157 bits (397), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 88/269 (32%), Positives = 147/269 (54%), Gaps = 16/269 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREIINHRS 71 D Y+ +++GSG F V + R+K + A K+I++ E+++RE+ + Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 ++HPN++ EV T + ++ E +GGELF+ + +E+EA F +Q+++GV Y Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 132 HAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++Q+ H DLK EN +L P PR+KI DFG + ++ K+ GTP ++APE+ + Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEI-V 189 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHIS 247 E G AD+WS GV Y++L GA PF + ++T+ + V Y D + + S Sbjct: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANVSAVNYEFEDEYFSNTS 245 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEW 276 + I R+ V DP KR++I + H W Sbjct: 246 ALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274 >3NCG-A nrPDB Length = 486 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 12/268 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 ++RY +V +G G+FG +D+ + + AVK I + K + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI++ E++ + IV E +GGELF+ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 135 QVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEV L+ Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEV-LRGTY 199 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA--IPDYVHISPECR 251 D K DVWS GV LY++L G PF KN + R+ +YA +P + IS + + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPF----YGKNEYDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLK 279 LI ++ P+ RI+ + H W K Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQK 282 >3MA6-A nrPDB Length = 298 Score = 155 bits (391), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 97/264 (36%), Positives = 143/264 (54%), Gaps = 9/264 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKID-ENVKREIINHRSLR 73 SDRY+ + +G G+FG L +DK + + AVK I + +K D E++ RE+ + L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 90 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 150 Query: 134 MQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL+ S ++I DFG S + K +GT YIAPEV L Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV-LHGT 209 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 210 YDEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG--KYTFELPQWKKVSESAKD 266 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 LI ++ P+ RIS + +HEW Sbjct: 267 LIRKMLTYVPSMRISARDALDHEW 290 >2BRG-A nrPDB Length = 297 Score = 154 bits (389), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 96/281 (34%), Positives = 154/281 (54%), Gaps = 21/281 (7%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREII 67 M +P + D ++LV+ +G G +G +L ++ + E VAVK ++ +D EN+K+EI Sbjct: 1 MAVPFVED---WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEIC 57 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 ++ L H N+V+F + +EY SGGELF+RI E +A+ FF QL++G Sbjct: 58 INKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIA 184 V Y H + + HRD+K EN LLD LKI DFG + +++ + GT Y+A Sbjct: 118 VVYLHGIGITHRDIKPENLLLDER--DNLKISDFGLATVFRYNNRERLLNKMCGTLPYVA 175 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP----EEPKNFRKTIHRILNVQYAI 240 PE+L ++E+ + DVWSCG+ L ML G P++ P +E ++++ Y Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKE------KKTYLN 229 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 P + I L+ +I V +P+ RI+IP+I+ W+ K L Sbjct: 230 P-WKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 269 >2JC6-A nrPDB Length = 334 Score = 154 bits (388), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 91/261 (34%), Positives = 135/261 (51%), Gaps = 10/261 (3%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPNIV 78 +E + +G+G F L +K + +L AVK I + + + +++ EI R ++H NIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 +++ +P HL +VM+ SGGELF+RI G ++E +A +Q++ V Y H M + H Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 143 Query: 139 RDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 RDLK EN L ++ I DFG SK + GTP Y+APEVL +K Y K Sbjct: 144 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKA 202 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPECRHLIS 255 D WS GV Y++L G PF D + K F +IL +Y P + IS + I Sbjct: 203 VDCWSIGVIAYILLCGYPPFYDENDSKLF----EQILKAEYEFDSPYWDDISDSAKDFIR 258 Query: 256 RIFVADPAKRISIPEIRNHEW 276 + DP KR + + H W Sbjct: 259 NLMEKDPNKRYTCEQAARHPW 279 >4FG9-A nrPDB Length = 320 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 100/287 (34%), Positives = 143/287 (49%), Gaps = 14/287 (4%) Query: 5 AVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENV 62 AV GP D Y+ +G+G F L DK++ +LVA+K I E E + ++ Sbjct: 4 AVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSM 63 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + EI ++HPNIV ++ + HL ++M+ SGGELF+RI G ++E +A Sbjct: 64 ENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF 123 Query: 123 QLISGVSYCHAMQVCHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 Q++ V Y H + + HRDLK EN L LD ++ I DFG SK S + GT Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDED--SKIMISDFGLSKMEDPGSVLSTACGT 181 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 P Y+APEVL +K Y K D WS GV Y++L G PF D + K F +IL +Y Sbjct: 182 PGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFE----QILKAEYE 236 Query: 240 I--PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPAD 284 P + IS + I + DP KR + + H W + D Sbjct: 237 FDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD 283 >3BHH-A nrPDB Length = 295 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 94/264 (35%), Positives = 141/264 (53%), Gaps = 8/264 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +DIG G F V R + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 NIVR + I +V + +GGELFE I +SE +A QQ++ V +CH M Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 V HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ K +++ + + P++ ++PE ++ Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--KAGAYDFPSPEWDTVTPEAKN 239 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 LI+++ +PAKRI+ E H W Sbjct: 240 LINQMLTINPAKRITAHEALKHPW 263 >6CMJ-A nrPDB Length = 321 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 101/284 (35%), Positives = 149/284 (52%), Gaps = 34/284 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID------------ENVKREI 66 D+Y L +IG G++GV +L ++ N A+K + + + I E V +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 67 INHRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 + L HPN+V+ EV+ P HL +V E + G + E + SED+ARF+FQ L Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDL 152 Query: 125 ISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSK----SSVLHSQPKSTVG 178 I G+ Y H ++ HRD+K N L+ DG +KI DFG S S L S +TVG Sbjct: 153 IKGIEYLHYQKIIHRDIKPSNLLVGEDG----HIKIADFGVSNEFKGSDALLS---NTVG 205 Query: 179 TPAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 TPA++APE L +K + GK DVW+ GVTLY + G PF D + +I + Sbjct: 206 TPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERIMCLHSKIKSQ 261 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 PD I+ + + LI+R+ +P RI +PEI+ H W ++ Sbjct: 262 ALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >4UZD-A nrPDB Length = 287 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 93/282 (32%), Positives = 152/282 (53%), Gaps = 16/282 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE----KIDENVKREIINHRSLRHPN 76 +E+ + +G G FG L R+KQS ++A+K + + + ++ ++RE+ LRHPN Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I+R T + +++EYA G ++ + +F E + +L + +SYCH+ +V Sbjct: 70 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 129 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRD+K EN LL GS A LKI DFG+S + S+ + GT Y+ PE++ + +D K Sbjct: 130 IHRDIKPENLLL-GS-AGELKIADFGWSVHAP-SSRRTTLCGTLDYLPPEMIEGRMHDEK 186 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 V D+WS GV Y LVG PF E +++T RI V++ PD+V + R LISR Sbjct: 187 V-DLWSLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDFV--TEGARDLISR 239 Query: 257 IFVADPAKRISIPEIRNHEWFLKN--LPADLMNDNTMTTQFD 296 + +P++R + E+ H W N P++ N + + Sbjct: 240 LLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAAAALE 281 >5FG8-A nrPDB Length = 285 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/267 (33%), Positives = 143/267 (53%), Gaps = 8/267 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID---ENVKREIINHRSLRH 74 SD Y++ +++G G F + + K + A K I + + ++RE R L H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I + +V + +GGELFE I +SE +A QQ++ V++CH Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYS-KSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 V HRDLK EN LL + +K+ DFG + + H GTP Y++PEVL K+ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ + + + + Y P++ ++PE ++ Sbjct: 193 Y-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI--KAGAYDYPSPEWDTVTPEAKN 249 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLK 279 LI+++ +P KRI+ E H W + Sbjct: 250 LINQMLTVNPNKRITAAEALKHPWICQ 276 >3DFA-A nrPDB Length = 286 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 12/268 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 ++RY +V +G G+FG +D+ + + AVK I + K + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI++ E++ + IV E +GGELF+ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 135 QVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEV L+ Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEV-LRGTY 199 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA--IPDYVHISPECR 251 D K DVWS GV LY++L G PF KN + R+ +YA +P + IS + + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYG----KNEYDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLK 279 LI ++ P+ RI+ + H W K Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQK 282 >5U6Y-A nrPDB Length = 461 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/261 (34%), Positives = 140/261 (53%), Gaps = 8/261 (3%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRHPNI 77 Y+L +++G G F V R + + A K I + + + ++RE R L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 VR + I H ++ + +GGELFE I +SE +A QQ++ V +CH M V Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 138 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKEYDG 195 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K Y G Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 180 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 K D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + LI+ Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 256 RIFVADPAKRISIPEIRNHEW 276 ++ +P+KRI+ E H W Sbjct: 239 KMLTINPSKRITAAEALKHPW 259 >3KN6-A nrPDB Length = 325 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 93/261 (35%), Positives = 141/261 (54%), Gaps = 11/261 (4%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEV 83 K +G G+F + R K+SN+ AVK I + +++ N ++EI + HPNIV+ EV Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK--RMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 H +VME +GGELFERI FSE EA + ++L+S VS+ H + V HRDLK Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 144 ENTLL-DGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKEYDGKVADVW 201 EN L D + +KI DFG+++ +QP K+ T Y APE+L + YD + D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLW 193 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ-----YAIPDYVHISPECRHLISR 256 S GV LY ML G PF+ + + + ++ + + ++S E + LI Sbjct: 194 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 253 Query: 257 IFVADPAKRISIPEIRNHEWF 277 + DP KR+ + +R +EW Sbjct: 254 LLTVDPNKRLKMSGLRYNEWL 274 >2VN9-A nrPDB Length = 301 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 91/267 (34%), Positives = 143/267 (53%), Gaps = 8/267 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +++G G F V R + + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I +V + +GGELFE I +SE +A QQ++ V++CH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 + HRDLK EN LL S +K+ DFG + Q GTP Y++PEVL K Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 239 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLK 279 LI+++ +PAKRI+ E H W + Sbjct: 240 LINKMLTINPAKRITASEALKHPWICQ 266 >2VZ6-A nrPDB Length = 313 Score = 152 bits (383), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 90/261 (34%), Positives = 140/261 (53%), Gaps = 8/261 (3%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRHPNI 77 Y+L +++G G F V R + + A K I + + + ++RE R L+HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 VR + I H ++ + +GGELFE I +SE +A QQ++ V +CH M V Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 143 Query: 138 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKEYDG 195 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K Y G Sbjct: 144 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 202 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 K D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + LI+ Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKDLIN 260 Query: 256 RIFVADPAKRISIPEIRNHEW 276 ++ +P+KRI+ E H W Sbjct: 261 KMLTINPSKRITAAEALKHPW 281 >3Q5I-A nrPDB Length = 504 Score = 151 bits (381), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 97/279 (34%), Positives = 145/279 (51%), Gaps = 23/279 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--------------EKIDENVK 63 + Y V+ +GSG +G L ++K + A+K I++ EK E + Sbjct: 35 GESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 EI +SL HPNI++ +V + +V E+ GGELFE+I N +F E +A +Q Sbjct: 95 NEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQ 154 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 ++SG+ Y H + HRD+K EN LL+ + +KI DFG S + + +GT Y Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP- 241 IAPEV LKK+Y+ K DVWSCGV +Y++L G YP P +N + I ++ +Y Sbjct: 215 IAPEV-LKKKYNEK-CDVWSCGVIMYILLCG-YP---PFGGQNDQDIIKKVEKGKYYFDF 268 Query: 242 -DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 D+ +IS E + LI + D KR + E N W K Sbjct: 269 NDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 >5IG1-A nrPDB Length = 344 Score = 150 bits (380), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 94/287 (32%), Positives = 152/287 (52%), Gaps = 18/287 (6%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----RGEKIDENVKREIINHR 70 ++D D + IG G F +K++ E+ AVK I R +I++ +KREI Sbjct: 13 LYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINK-IKREIGICS 71 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 SL+H +IV + +H +V EY SGGELF+ I ++E +A Q++S + + Sbjct: 72 SLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQH 131 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEV 187 CH+ + HRDLK EN LL P +KI DFG + ++ P GTP Y++PEV Sbjct: 132 CHSKNIIHRDLKPENLLLASKDPNAPVKITDFGL--AVIMEQGPTYFGFAGTPGYLSPEV 189 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVH 245 + + YD V DVW+CGV LY++LVG PF + ++ +K +I N QY P++ Sbjct: 190 IRRVPYDTAV-DVWACGVILYILLVGYPPFWE----EDHQKLYAQIKNCQYDFPSPEWDS 244 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFL-KNLPADLMNDNTM 291 ++ + LI + +P +R ++ E+ H W +++P + T+ Sbjct: 245 VTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSVHRQATL 291 >3D2K-A nrPDB Length = 272 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 90/277 (32%), Positives = 150/277 (54%), Gaps = 14/277 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE----KIDENVK 63 GP+ + +++ + +G G FG L R++QS ++A+K + + + ++ ++ Sbjct: 1 GPLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR 60 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 RE+ LRHPNI+R T + +++EYA G ++ + RF E + + Sbjct: 61 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITE 120 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 L + +SYCH+ +V HRD+K EN LL GS LKI DFG+S + S+ + GT Y+ Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLL-GSNG-ELKIADFGWSVHAP-SSRRTTLCGTLDYL 177 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 PE++ + +D KV D+WS GV Y LVG PF E +++T RI V++ PD+ Sbjct: 178 PPEMIEGRMHDEKV-DLWSLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDF 232 Query: 244 VHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 V + R LISR+ + ++R+++ E+ H W N Sbjct: 233 V--TEGARDLISRLLKHNASQRLTLAEVLEHPWIKAN 267 >3SOA-A nrPDB Length = 444 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 88/264 (33%), Positives = 141/264 (53%), Gaps = 8/264 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 ++ Y+L +++G G F V R + + A I + + + ++RE R L+H Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I H ++ + +GGELFE I +SE +A QQ++ V +CH M Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 135 QVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 V HR+LK EN LL +K+ DFG + Q GTP Y++PEVL K Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + Sbjct: 190 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 246 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 LI+++ +P+KRI+ E H W Sbjct: 247 LINKMLTINPSKRITAAEALKHPW 270 >4RGJ-A nrPDB Length = 520 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 95/276 (34%), Positives = 142/276 (51%), Gaps = 10/276 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---EKID-ENVKREIINHRSLR 73 +++Y+ +K +G G+FG L RDK + A+K I + K D E++ RE+ + L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NI++ E + +V + +GGELF+ I + RF E +A +Q++SG++Y H Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHK 178 Query: 134 MQVCHRDLKLENTLLDGSPAPRL--KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 V HRDLK EN LL+ + KI DFG S + K +GT YIAP+V L Sbjct: 179 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV-LHG 237 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 YD K D+WSCGV LY++L G PF E +K + +P + IS + + Sbjct: 238 TYDEK-CDIWSCGVILYILLSGCPPFNGSNEYDILKKV--EAGKYTFDLPQFKKISDKAK 294 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 LI ++ + A RIS + HEW D +N Sbjct: 295 DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLN 330 >3LIJ-A nrPDB Length = 494 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 93/265 (35%), Positives = 140/265 (52%), Gaps = 8/265 (3%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSL 72 H S+ Y+ VK +GSG +G L RDK ++ A+K I + + + E+ + L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 HPNI++ + + +VME GGELF+ I + +F+E +A +Q++SGV+Y H Sbjct: 94 DHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 133 AMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + HRDLK EN LL+ L KI DFG S + K +GT YIAPEV L+K Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEV-LRK 212 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 +YD K DVWS GV L+++L G PF + + RK + P++ ++S + Sbjct: 213 KYDEK-CDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKG--KYTFDSPEWKNVSEGAK 269 Query: 252 HLISRIFVADPAKRISIPEIRNHEW 276 LI ++ D +RIS + H W Sbjct: 270 DLIKQMLQFDSQRRISAQQALEHPW 294 >4MVF-A nrPDB Length = 506 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 93/265 (35%), Positives = 141/265 (53%), Gaps = 16/265 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHP 75 D+Y + + +G G +G DK +N+L A+K E+ +++ +N+ R EI + L HP Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRL-KNINRFFQEIEIMKKLDHP 114 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 NIV+ E ++ ++ME SG ELF+ I G F+E A +Q+ S + Y H++ Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 136 VCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRDLK EN L + LKI DFG SK+ + GTP Y+AP+VL K YD Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK-YD 233 Query: 195 GKVADVWSCGVTLYVMLVGAYPF---EDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 K D+WS GV +Y +L G PF D E K +K + D+ IS + + Sbjct: 234 KK-CDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKG-----EFCFYENDWGSISSDAK 287 Query: 252 HLISRIFVADPAKRISIPEIRNHEW 276 +LI+++ +P +R +I E NH W Sbjct: 288 NLITKLLTYNPNERCTIEEALNHPW 312 >2V7O-A nrPDB Length = 336 Score = 147 bits (370), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 89/264 (33%), Positives = 140/264 (53%), Gaps = 8/264 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +++G G F V R K + A K I + + + ++RE R L+H Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I +V + +GGELFE I +SE +A Q++ V++ H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 + HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ K +++ + + P++ ++PE ++ Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--KAGAYDFPSPEWDTVTPEAKN 266 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 LI+++ +PAKRI+ + H W Sbjct: 267 LINQMLTINPAKRITADQALKHPW 290 >2JAM-A nrPDB Length = 304 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 87/252 (34%), Positives = 133/252 (52%), Gaps = 6/252 (2%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSLRHPNIVRFKEVIL 85 +GSG F L++ + + +L A+K I++ D +++ EI + ++H NIV +++ Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYE 76 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 + TH +VM+ SGGELF+RI G ++E +A QQ++S V Y H + HRDLK EN Sbjct: 77 STTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPEN 136 Query: 146 TL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCG 204 L L ++ I DFG SK + + GTP Y+APEVL +K Y K D WS G Sbjct: 137 LLYLTPEENSKIMITDFGLSKME-QNGIMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIG 194 Query: 205 VTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAK 264 V Y++L G PF + E K F K ++ P + IS + I + DP + Sbjct: 195 VITYILLCGYPPFYEETESKLFEKIKEGYY--EFESPFWDDISESAKDFICHLLEKDPNE 252 Query: 265 RISIPEIRNHEW 276 R + + +H W Sbjct: 253 RYTCEKALSHPW 264 >2BDW-A nrPDB Length = 362 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 140/268 (52%), Gaps = 13/268 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 SD Y++ +++G G F V R K + A K I + + + ++RE R L+H Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 87 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I + +V + +GGELFE I +SE +A QQ++ ++YCH+ Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HR+LK EN LL + +K+ DFG + GTP Y++PEVL K Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 K D+W+CGV LY++LVG PF D ++ + + + + Y P++ ++PE + L Sbjct: 208 S-KPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 264 Query: 254 ISRIFVADPAKRIS------IPEIRNHE 275 I + +P KRI+ +P I N E Sbjct: 265 IDSMLTVNPKKRITADQALKVPWICNRE 292 >5YV8-A nrPDB Length = 298 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 100/295 (33%), Positives = 147/295 (49%), Gaps = 49/295 (16%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID------------------- 59 ++Y L +IG G++GV +L ++ N A+K + + + I Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 60 --------ENVKREIINHRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNA 109 E V +EI + L HPN+V+ EV+ P HL +V E + G + E + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 131 Query: 110 GRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSK-- 165 SED+ARF+FQ LI G+ Y H ++ HRD+K N L+ DG +KI DFG S Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG----HIKIADFGVSNEF 187 Query: 166 --SSVLHSQPKSTVGTPAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE 221 S L S +TVGTPA++APE L +K + GK DVW+ GVTLY + G PF D Sbjct: 188 KGSDALLS---NTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-- 242 Query: 222 EPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEW 276 + +I + PD I+ + + LI+R+ +P RI +PEI+ H W Sbjct: 243 --ERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >3KK8-A nrPDB Length = 284 Score = 144 bits (363), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 140/268 (52%), Gaps = 13/268 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 SD Y++ +++G G F V R K + A K I + + + ++RE R L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I + +V + +GGELFE I +SE +A QQ++ ++YCH+ Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HR+LK EN LL + +K+ DFG + GTP Y++PEVL K Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 K D+W+CGV LY++LVG PF D ++ + + + + Y P++ ++PE + L Sbjct: 185 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 241 Query: 254 ISRIFVADPAKRIS------IPEIRNHE 275 I + +P KRI+ +P I N E Sbjct: 242 IDSMLTVNPKKRITADQALKVPWICNRE 269 >1ZWS-A nrPDB Length = 288 Score = 144 bits (362), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 143/269 (53%), Gaps = 16/269 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDENVKREIINHRS 71 D Y++ +++GSG F + + R+K + A K+I++ + E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + H N++ +V T + +++E SGGELF+ + SE+EA F +Q++ GV+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 132 HAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H ++ H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHIS 247 E G AD+WS GV Y++L GA PF + ++T+ I +V Y + + H S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITSVSYDFDEEFFSHTS 246 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEW 276 + I ++ V + KR++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4YZB-A nrPDB Length = 491 Score = 144 bits (362), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 92/265 (34%), Positives = 136/265 (51%), Gaps = 9/265 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLR- 73 SDRY+ + +G G+FG L +DK + + AVK I + +K D+ + + + Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 148 Query: 134 MQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL+ ++I DFG S + K +GT YIAPEV L Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEV-LHGT 207 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 208 YDEK-CDVWSTGVILYILLSGCPPFNGANEFDILKKVEKG--KFTFDLPQWKKVSEPAKD 264 Query: 253 LISRIFVADPAKRISIPEIRNHEWF 277 LI ++ P RIS + HEW Sbjct: 265 LIRKMLAYVPTMRISARDALEHEWL 289 >2YAB-A nrPDB Length = 361 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 142/269 (52%), Gaps = 16/269 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDENVKREIINHRS 71 D Y++ +++GSG F + + R+K + A K+I++ + E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ 71 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + HPNI+ +V T + +++E SGGELF+ + SE+EA F +Q++ GV+Y Sbjct: 72 VLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 132 HAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H ++ H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHIS 247 E G AD+WS GV Y++L GA PF + ++T+ I V Y + + S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSYDFDEEFFSQTS 246 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEW 276 + I ++ V + KR++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4B8L-A nrPDB Length = 286 Score = 143 bits (360), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 87/269 (32%), Positives = 142/269 (52%), Gaps = 20/269 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSLRH 74 D +++ + +G G FG L R+KQ+ ++A+K + + E ++ ++REI LRH Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI+R + +++E+A GEL++ + GRF E + F ++L + YCH Sbjct: 75 PNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHER 134 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVLLKK 191 +V HRD+K EN L+ LKI DFG+S +H+ + ++ GT Y+ PE++ K Sbjct: 135 KVIHRDIKPENLLMGYKGE--LKIADFGWS----VHAPSLRRRTMCGTLDYLPPEMIEGK 188 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 +D KV D+W GV Y LVG PF+ P + R RI+NV P + +S + Sbjct: 189 THDEKV-DLWCAGVLCYEFLVGMPPFDSPSHTETHR----RIVNVDLKFPPF--LSDGSK 241 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKN 280 LIS++ P +R+ + + H W N Sbjct: 242 DLISKLLRYHPPQRLPLKGVMEHPWVKAN 270 >2JDO-A nrPDB Length = 342 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 98/283 (34%), Positives = 143/283 (50%), Gaps = 25/283 (8%) Query: 8 GPMDLPI-MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI--DENVKR 64 G MD + M+D D +L +G G FG L+R+K + A+K I R E I + V Sbjct: 1 GAMDPKVTMNDFDYLKL---LGKGTFGKVILVREKATGRYYAMK-ILRKEVIIAKDEVAH 56 Query: 65 EIINHRSL---RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFF 121 + R L RHP + K T L VMEYA+GGELF + F+E+ ARF+ Sbjct: 57 TVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYG 116 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTP 180 +++S + Y H+ V +RD+KLEN +LD +KI DFG K + K+ GTP Sbjct: 117 AEIVSALEYLHSRDVVYRDIKLENLMLDKD--GHIKITDFGLCKEGISDGATMKTFCGTP 174 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Y+APEVL +Y G+ D W GV +Y M+ G PF + + + F IL + Sbjct: 175 EYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF----ELILMEEIRF 229 Query: 241 PDYVHISPECRHLISRIFVADPAKRIS-----IPEIRNHEWFL 278 P +SPE + L++ + DP +R+ E+ H +FL Sbjct: 230 PR--TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 >6FDY-U nrPDB Length = 276 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 87/271 (32%), Positives = 145/271 (53%), Gaps = 11/271 (4%) Query: 19 DRYELVKDIGSGNFG-VARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRH 74 D + L + +GSG + V + K + E+VA+K + + + EN+ EI + +RH Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 70 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P+IV+ K+ ++ ++ME+ +GG+L I E AR F QQL S + + H Sbjct: 71 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 130 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + H DLK +N LL P LK+ DFG+++ + G+P Y+APE++ +++YD Sbjct: 131 NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYD 190 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL-NVQYAIPDYVHISPECRHL 253 +V D+WS GV LY L G PF ++F + +I N +P +S +CR L Sbjct: 191 ARV-DLWSMGVILYEALFGQPPFAS----RSFSELEEKIRSNRVIELPLRPLLSRDCRDL 245 Query: 254 ISRIFVADPAKRISIPEIRNHEWF-LKNLPA 283 + R+ DP++RIS + H W L+++P+ Sbjct: 246 LQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >5N23-A nrPDB Length = 352 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 145/268 (54%), Gaps = 19/268 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 D++E ++ +G+G+FG L++ K++ A+K +++ + + +N + ++ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +V+EYA GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +K+ DFG++K V P + GTP Y+APE++L K Y+ Sbjct: 162 DLIYRDLKPENLLIDQQGY--IKVADFGFAK-RVKGRTPWTLCGTPEYLAPEIILSKGYN 218 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 219 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 271 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 + D KR + +I+NH+WF Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >5JZN-A nrPDB Length = 280 Score = 140 bits (353), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 80/265 (30%), Positives = 143/265 (53%), Gaps = 11/265 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE--KIDENVKREIINHRSLRHP 75 ++RY++ + IG GNF V + ++ + A+K I++ + + ++ E+ R ++HP Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 NIV E + PT L +VME GG+LF+ I + +++E +A L S + Y H++ Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 136 VCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + HRD+K EN L+ DGS + LK+ DFG ++++ + GTP Y+APE++ + Sbjct: 138 IVHRDIKPENLLVYEHQDGSKS--LKLGDFGL--ATIVDGPLYTVCGTPTYVAPEIIAET 193 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Y KV D+W+ GV Y++L G PF + + + V + P + ++S + Sbjct: 194 GYGLKV-DIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 252 Query: 252 HLISRIFVADPAKRISIPEIRNHEW 276 LI+ + + D +R S ++ H W Sbjct: 253 ELITMMLLVDVDQRFSAVQVLEHPW 277 >3MV5-A nrPDB Length = 342 Score = 139 bits (351), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 92/270 (34%), Positives = 139/270 (51%), Gaps = 20/270 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-VKREIINHRSL---RH 74 + +E +K +G G FG L+++K + A+K +++ + ++ V + +R L RH Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y H+ Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 129 Query: 135 Q-VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKE 192 + V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 130 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 187 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y G+ D W GV +Y M+ G PF + + K F IL + P + PE + Sbjct: 188 Y-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEEIRFPR--TLGPEAKS 240 Query: 253 LISRIFVADPAKRIS-----IPEIRNHEWF 277 L+S + DP +R+ EI H +F Sbjct: 241 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 270 >2A27-A nrPDB Length = 321 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 83/269 (30%), Positives = 141/269 (52%), Gaps = 16/269 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDENVKREIINHRS 71 D Y++ +++GSG F + + R+K + A K+I++ + E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + H N++ +V T + +++E SGGELF+ + SE+EA F +Q++ GV+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 132 HAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H ++ H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHIS 247 E G AD+WS GV Y++L GA PF + ++T+ I V Y + + S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSYDFDEEFFSQTS 246 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEW 276 + I ++ V + KR++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >5KCV-A nrPDB Length = 460 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 92/270 (34%), Positives = 139/270 (51%), Gaps = 20/270 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-VKREIINHRSL---RH 74 + +E +K +G G FG L+++K + A+K +++ + ++ V + +R L RH Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y H+ Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 281 Query: 135 Q-VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKE 192 + V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 282 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 339 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y G+ D W GV +Y M+ G PF + + K F IL + P + PE + Sbjct: 340 Y-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEEIRFPR--TLGPEAKS 392 Query: 253 LISRIFVADPAKRIS-----IPEIRNHEWF 277 L+S + DP +R+ EI H +F Sbjct: 393 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 422 >5D9K-A nrPDB Length = 330 Score = 139 bits (349), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 83/275 (30%), Positives = 153/275 (55%), Gaps = 25/275 (9%) Query: 17 DSDRYELVKDIGSGNFGVARLMRD---KQSNELVAVKYIERG-----EKIDENVKREIIN 68 D ++EL+K +G G+FG L++ + +L A+K +++ +++ ++R+I+ Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 + HP IV+ T L +++++ GG+LF R+ F+E++ +F+ +L + Sbjct: 88 --EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 145 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEV 187 + H++ + +RDLK EN LLD +K+ DFG SK S+ H + S GT Y+APEV Sbjct: 146 DHLHSLGIIYRDLKPENILLD--EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 203 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + ++ + + AD WS GV ++ ML G PF+ K+ ++T+ IL + +P + +S Sbjct: 204 VNRRGHT-QSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQF--LS 256 Query: 248 PECRHLISRIFVADPAKRI-----SIPEIRNHEWF 277 PE + L+ +F +PA R+ + EI+ H +F Sbjct: 257 PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 291 >5X3F-B nrPDB Length = 393 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 80/268 (29%), Positives = 145/268 (54%), Gaps = 20/268 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR----SLRH 74 D+++ +K +G+G+FG L++ K+S A+K +++ + + +N + ++ Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +VMEY +GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 144 PFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 203 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 204 DLIYRDLKPENLLIDQQGY--IQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 259 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 260 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 312 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 + D KR + +I+NH+WF Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >5F9E-A nrPDB Length = 353 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 91/264 (34%), Positives = 145/264 (54%), Gaps = 16/264 (6%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RHP 75 +EL K +G G+FG L K++N+ A+K +++ + D++V+ ++ R L HP Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T +L VMEY +GG+L I + +F A F+ ++I G+ + H+ Sbjct: 81 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG 140 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-HSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLKL+N LLD +KI DFG K ++L ++ GTP YIAPE+LL ++Y+ Sbjct: 141 IVYRDLKLDNILLDKD--GHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYN 198 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 V D WS GV LY ML+G PF +E + F R+ N Y P + + E + L+ Sbjct: 199 HSV-DWWSFGVLLYEMLIGQSPFHGQDEEELFHSI--RMDNPFY--PRW--LEKEAKDLL 251 Query: 255 SRIFVADPAKRISI-PEIRNHEWF 277 ++FV +P KR+ + +IR H F Sbjct: 252 VKLFVREPEKRLGVRGDIRQHPLF 275 >1FOT-A nrPDB Length = 318 Score = 137 bits (345), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 152/293 (51%), Gaps = 21/293 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPN 76 +++++ +G+G+FG L+R + + A+K +++ K E+ E + + HP Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I+R + ++M+Y GGELF + + RF A+F+ ++ + Y H+ + Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDI 127 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 +RDLK EN LLD + +KI DFG++K + + GTP YIAPEV+ K Y+ K Sbjct: 128 IYRDLKPENILLDKN--GHIKITDFGFAK--YVPDVTYTLCGTPDYIAPEVVSTKPYN-K 182 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 D WS G+ +Y ML G PF D N KT +ILN + P + + + + L+SR Sbjct: 183 SIDWWSFGILIYEMLAGYTPFYD----SNTMKTYEKILNAELRFPPF--FNEDVKDLLSR 236 Query: 257 IFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQS 304 + D ++R+ +++NH WF + + L++ N + T ++ Q GQ Sbjct: 237 LITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRN-IETPYEPPIQQGQG 288 >4WB7-A nrPDB Length = 405 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 80/268 (29%), Positives = 144/268 (53%), Gaps = 20/268 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR----SLRH 74 D++E +K +G+G+FG L++ K++ A+K +++ + + +N + ++ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 215 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 216 DLIYRDLKPENLLIDQQGY--IQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 271 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 272 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 324 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 + D KR + +I+NH+WF Sbjct: 325 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >3HDN-A nrPDB Length = 373 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 89/280 (31%), Positives = 140/280 (50%), Gaps = 20/280 (7%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREII 67 GP P SD + +K IG G+FG L R K AVK +++ + + ++ I+ Sbjct: 28 GPSSNPHAKPSD-FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 86 Query: 68 NHRSL-----RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + R++ +HP +V T L V++Y +GGELF + F E ARF+ Sbjct: 87 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 146 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPA 181 ++ S + Y H++ + +RDLK EN LLD + + DFG K ++ H+ ST GTP Sbjct: 147 EIASALGYLHSLNIVYRDLKPENILLDSQ--GHIVLTDFGLCKENIEHNSTTSTFCGTPE 204 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+APEVL K+ YD + D W G LY ML G PF + + +++ L ++ Sbjct: 205 YLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK---- 259 Query: 242 DYVHISPECRHLISRIFVADPAKRISIP----EIRNHEWF 277 +I+ RHL+ + D KR+ EI++H +F Sbjct: 260 --PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >4I6B-A nrPDB Length = 308 Score = 134 bits (338), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 87/283 (30%), Positives = 146/283 (51%), Gaps = 22/283 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--------ERGEKIDENVKREIINHRS 71 RY K +G G F M D +N++ A K I + EKID +EI HR Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKID----KEIELHRI 84 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 L H ++V+F ++ I++EY S + + +E E R++ +Q++SG+ Y Sbjct: 85 LHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYL 144 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLK 190 H ++ HRDLKL N ++ S LK+ DFG ++ L + ++ GTP Y++PEV L Sbjct: 145 HEQEILHRDLKLGNFFINES--MELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV-LN 201 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 K+ G +D+W+ G +Y ML+G PFE N ++T I +Y +P + ++P Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPFET----TNLKETYRSIREARYTMPSSL-LAP-A 255 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 +HLI+ + +P R S+ +I H++F + D ++ + T Sbjct: 256 KHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHT 298 >1KOA-A nrPDB Length = 491 Score = 134 bits (337), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 83/275 (30%), Positives = 138/275 (50%), Gaps = 11/275 (4%) Query: 9 PMDLPIMHDS--DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKRE 65 P + I HD D Y++ +++G+G FGV + ++ + A K++ + D E V++E Sbjct: 39 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKE 98 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQL 124 I LRHP +V + + ++ E+ SGGELFE++ + + SEDEA + +Q+ Sbjct: 99 IQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQV 158 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 G+ + H H DLK EN + + LK+ DFG + K T GT + A Sbjct: 159 CKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAA 218 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD-- 242 PEV K G D+WS GV Y++L G PF +N +T+ + + + + D Sbjct: 219 PEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGG----ENDDETLRNVKSCDWNMDDSA 273 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 + IS + + I ++ +ADP R++I + H W Sbjct: 274 FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >3IS5-A nrPDB Length = 285 Score = 134 bits (337), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 89/266 (33%), Positives = 141/266 (53%), Gaps = 12/266 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 D + + +GSG FG L+ ++ S +K I +R + E ++ EI +SL HPN Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPN 81 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNA---GR-FSEDEARFFFQQLISGVSYCH 132 I++ EV ++ IVME GGEL ERI +A G+ SE +Q+++ ++Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 133 AMQVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + V H+DLK EN L D SP +KI DFG ++ + GT Y+APEV K+ Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEV-FKR 200 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 + K D+WS GV +Y +L G PF + +K ++ N YA+ + ++P+ Sbjct: 201 DVTFK-CDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPN--YAV-ECRPLTPQAV 256 Query: 252 HLISRIFVADPAKRISIPEIRNHEWF 277 L+ ++ DP +R S ++ +HEWF Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWF 282 >3UTO-A nrPDB Length = 573 Score = 134 bits (337), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 83/275 (30%), Positives = 138/275 (50%), Gaps = 11/275 (4%) Query: 9 PMDLPIMHDS--DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKRE 65 P + I HD D Y++ +++G+G FGV + ++ + A K++ + D E V++E Sbjct: 145 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKE 204 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQL 124 I LRHP +V + + ++ E+ SGGELFE++ + + SEDEA + +Q+ Sbjct: 205 IQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQV 264 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 G+ + H H DLK EN + + LK+ DFG + K T GT + A Sbjct: 265 CKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAA 324 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD-- 242 PEV K G D+WS GV Y++L G PF +N +T+ + + + + D Sbjct: 325 PEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGG----ENDDETLRNVKSCDWNMDDSA 379 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 + IS + + I ++ +ADP R++I + H W Sbjct: 380 FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >2X4F-A nrPDB Length = 373 Score = 134 bits (336), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 82/255 (32%), Positives = 129/255 (50%), Gaps = 9/255 (3%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G FG + + +A K I+ RG K E VK EI L H N+++ + Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFE 156 Query: 86 TPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 + + +VMEY GGELF+RI + +E + F +Q+ G+ + H M + H DLK E Sbjct: 157 SKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPE 216 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCG 204 N L A ++KI DFG ++ + K GTP ++APEV + ++ D+WS G Sbjct: 217 NILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV-VNYDFVSFPTDMWSVG 275 Query: 205 VTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHISPECRHLISRIFVADP 262 V Y++L G PF N +T++ IL ++ + D + IS E + IS++ + + Sbjct: 276 VIAYMLLSGLSPFLGD----NDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEK 331 Query: 263 AKRISIPEIRNHEWF 277 + RIS E H W Sbjct: 332 SWRISASEALKHPWL 346 >3TXO-A nrPDB Length = 353 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 85/255 (33%), Positives = 130/255 (50%), Gaps = 15/255 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----R 73 D +E ++ +G G+FG L R K++ +L AVK +++ + D++V+ + R L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HP + + TP L VME+ +GG+L I + RF E ARF+ ++IS + + H Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 142 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKE 192 + +RDLKL+N LLD K+ DFG K + + +T GTP YIAPE+L + Sbjct: 143 KGIIYRDLKLDNVLLDHE--GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y G D W+ GV LY ML G PFE E F ILN + P ++H + Sbjct: 201 Y-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEA----ILNDEVVYPTWLH--EDATG 253 Query: 253 LISRIFVADPAKRIS 267 ++ +P R+ Sbjct: 254 ILKSFMTKNPTMRLG 268 >2Z7Q-A nrPDB Length = 321 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 82/275 (29%), Positives = 149/275 (54%), Gaps = 25/275 (9%) Query: 17 DSDRYELVKDIGSGNFGVARLMRD---KQSNELVAVKYIERG-----EKIDENVKREIIN 68 D +EL+K +G G+FG L+R S L A+K +++ +++ ++R+I+ Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 + HP +V+ T L +++++ GG+LF R+ F+E++ +F+ +L G+ Sbjct: 86 --DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGL 143 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEV 187 + H++ + +RDLK EN LLD +K+ DFG SK ++ H + S GT Y+APEV Sbjct: 144 DHLHSLGIIYRDLKPENILLD--EEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV 201 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + ++ AD WS GV ++ ML G+ PF+ K+ ++T+ IL + +P + +S Sbjct: 202 -VNRQGHSHSADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQF--LS 254 Query: 248 PECRHLISRIFVADPAKRI-----SIPEIRNHEWF 277 E + L+ +F +PA R+ EI+ H ++ Sbjct: 255 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY 289 >4JG6-A nrPDB Length = 355 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 93/274 (33%), Positives = 145/274 (52%), Gaps = 25/274 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 +D YE+ +DIG G++ V + K +N AVK I++ ++ D + EI+ R +HPNI Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR-DPTEEIEIL-LRYGQHPNI 91 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + K+V ++ +V E GGEL ++I FSE EA + V Y HA V Sbjct: 92 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 138 HRDLKLENTL-LDGSPAPR-LKICDFGYSKSSVLHSQPKSTVGTPAY----IAPEVLLKK 191 HRDLK N L +D S P ++ICDFG++K L ++ + TP Y +APEVL ++ Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQ--LRAE-NGLLMTPCYTANFVAPEVLERQ 208 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFED-----PEEPKNFRKTIHRILNVQYAIPD--YV 244 YD D+WS GV LY ML G PF + PEE + RI + ++++ + Sbjct: 209 GYDA-ACDIWSLGVLLYTMLTGYTPFANGPDDTPEE------ILARIGSGKFSLSGGYWN 261 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 +S + L+S++ DP +R++ + H W + Sbjct: 262 SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIV 295 >2YCR-A nrPDB Length = 323 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 92/293 (31%), Positives = 144/293 (49%), Gaps = 22/293 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDE--NVKREIINH 69 D Y + K +GSG G +L ++++ + VA+K I + + D NV+ EI Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 + L HP I++ K + IV+E GGELF+++ R E + +F Q++ V Sbjct: 70 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H + HRDLK EN LL L KI DFG+SK S ++ GTP Y+APEVL Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 189 LKKEYDG--KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA-IPD-YV 244 + G + D WS GV L++ L G PF + + + +I + +Y IP+ + Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK---DQITSGKYNFIPEVWA 245 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWF----LKNLPADLMNDNTMTT 293 +S + L+ ++ V DP R + E H W +K DL+++ +T Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENEST 298 >4NIF-A nrPDB Length = 333 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 92/272 (33%), Positives = 145/272 (53%), Gaps = 25/272 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 SD Y + + IG G++ + K +N AVK I++ ++ D + + EI+ R +HPNI Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKR-DPSEEIEIL-LRYGQHPNI 64 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + K+V H+ +V E GGEL ++I FSE EA F + V Y H+ V Sbjct: 65 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 138 HRDLKLENTL-LDGSPAPR-LKICDFGYSKSSVLHSQPKSTVGTPAY----IAPEVLLKK 191 HRDLK N L +D S P L+ICDFG++K L ++ + TP Y +APEVL ++ Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQ--LRAE-NGLLMTPCYTANFVAPEVLKRQ 181 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFED-----PEEPKNFRKTIHRILNVQYAIP--DYV 244 YD + D+WS G+ LY ML G PF + PEE + RI + ++ + ++ Sbjct: 182 GYD-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEE------ILTRIGSGKFTLSGGNWN 234 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEW 276 +S + L+S++ DP +R++ ++ H W Sbjct: 235 TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >3DB8-A nrPDB Length = 317 Score = 131 bits (329), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 131/263 (49%), Gaps = 14/263 (5%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHP 75 RY + +G G F + D + E+ A K + + + E + EI H+SL +P Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNP 102 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 ++V F + +V+E L E +E EAR+F +Q I GV Y H + Sbjct: 103 HVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNR 162 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 V HRDLKL N L+ +KI DFG +K + K GTP YIAPEVL KK + Sbjct: 163 VIHRDLKLGNLFLNDDMD--VKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHS 220 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 +V D+WS G LY +LVG PFE ++T RI +Y++P HI+P LI Sbjct: 221 FEV-DIWSLGCILYTLLVGKPPFET----SCLKETYIRIKKNEYSVPR--HINPVASALI 273 Query: 255 SRIFVADPAKRISIPEIRNHEWF 277 R+ ADP R S+ E+ E+F Sbjct: 274 RRMLHADPTLRPSVAELLTDEFF 296 >5XZW-A nrPDB Length = 471 Score = 131 bits (329), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 131/266 (49%), Gaps = 16/266 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRFKEVI 84 +G G F + ++ + + AVK I + + I + V RE+ + L HP IVR K Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 263 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 +VME+ SGG+L + + G ED R +Q+++ + Y H+M + HRDLK + Sbjct: 264 EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPD 323 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK-------EYDGK- 196 N L++ +KI DFG +K S K+ GT AY+APEV+ K EY+ + Sbjct: 324 NILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERN 383 Query: 197 ----VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 + D+WS G +YV+L G PF + + + K I R + + D+ IS E R Sbjct: 384 EYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLY-KQIGRGSYHEGPLKDF-RISEEARD 441 Query: 253 LISRIFVADPAKRISIPEIRNHEWFL 278 I + DP R + + NH W + Sbjct: 442 FIDSLLQVDPNNRSTAAKALNHPWIV 467 >1NY3-A nrPDB Length = 400 Score = 130 bits (328), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 144/273 (52%), Gaps = 16/273 (5%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 D Y++ + G G G + +K++ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 116 Query: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 E + LI + +P +R++I E NH W +++ Sbjct: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 >2OZA-A nrPDB Length = 356 Score = 130 bits (327), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 144/273 (52%), Gaps = 16/273 (5%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 D Y++ + G G G + +K++ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 72 Query: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 193 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 251 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 E + LI + +P +R++I E NH W +++ Sbjct: 252 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 284 >3KA0-A nrPDB Length = 320 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 16/273 (5%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 D Y++ + G G G + +K++ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 70 Query: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 71 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ TP Y+APEVL Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLG 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 191 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 249 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 E + LI + +P +R++I E NH W +++ Sbjct: 250 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 282 >6CCF-A nrPDB Length = 290 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/296 (32%), Positives = 146/296 (49%), Gaps = 45/296 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----------------RGEKID--- 59 ++Y+L +IG G +GV RL ++ + A+K + RG + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 60 --------ENVKREIINHRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNA 109 E V +EI + L H N+V+ EV+ P +L +V + G + E C+ Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDK 124 Query: 110 GRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSS 167 FSE++AR + + +I G+ Y H ++ HRD+K N LL DG +KI DFG S Sbjct: 125 -PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDG----HVKIADFGVSNQF 179 Query: 168 VLH-SQPKSTVGTPAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK 224 + +Q ST GTPA++APE + + + GK DVW+ GVTLY + G PF D Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID----- 234 Query: 225 NFRKTIHR-ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +F +HR I N P+ IS E + LI ++ +P RI +P+I+ H W K Sbjct: 235 DFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >5DYK-A nrPDB Length = 853 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 89/290 (30%), Positives = 139/290 (47%), Gaps = 26/290 (8%) Query: 6 VSGPMDLPI-----MHDS----DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE 56 + GPM + M D+ D E + IG G FG +L+ K + A+K + + Sbjct: 517 IQGPMLAHLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRS 576 Query: 57 KIDENVKREIINHRSLR----HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRF 112 I+ N + I R + HP I+R + + E +GGEL++ I G Sbjct: 577 IINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLL 636 Query: 113 SEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 172 S+ +A+F+ +I + Y H + +RDLK EN LLD +K+ DFG +K + + Sbjct: 637 SKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLD--KQGYVKLIDFGCAKK--VQGR 692 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 + VGTP Y+APEV+L K Y G D+W+ G+ LY + G PF + EE + + Sbjct: 693 AYTLVGTPHYMAPEVILGKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQ--LEIFRD 749 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRI-----SIPEIRNHEWF 277 IL Q PDYV + +L+ R+ P RI +I++H +F Sbjct: 750 ILTGQLTFPDYV-TDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFF 798 >4AF3-A nrPDB Length = 292 Score = 129 bits (323), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 89/282 (31%), Positives = 146/282 (51%), Gaps = 21/282 (7%) Query: 7 SGPMDLPIMHDS-DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDEN 61 SG D+ H + D +E+ + +G G FG L R+K+S+ +VA+K + + E ++ Sbjct: 10 SGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQ 69 Query: 62 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFF 121 ++REI L HPNI+R + +++EYA GEL++ + + F E Sbjct: 70 LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIM 129 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVG 178 ++L + YCH +V HRD+K EN LL LKI DFG+S +H+ + K+ G Sbjct: 130 EELADALMYCHGKKVIHRDIKPENLLLGLKGE--LKIADFGWS----VHAPSLRRKTMCG 183 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 T Y+ PE++ + ++ KV D+W GV Y +LVG PFE + +R RI+ V Sbjct: 184 TLDYLPPEMIEGRMHNEKV-DLWCIGVLCYELLVGNPPFESASHNETYR----RIVKVDL 238 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 P V + LIS++ +P++R+ + ++ H W N Sbjct: 239 KFPASVPTGAQ--DLISKLLRHNPSERLPLAQVSAHPWVRAN 278 >3I6U-A nrPDB Length = 419 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 135/273 (49%), Gaps = 18/273 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDE--NVKREIINH 69 D Y + K +GSG G +L ++++ + VA++ I + + D NV+ EI Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 + L HP I++ K + IV+E GGELF+++ R E + +F Q++ V Sbjct: 195 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H + HRDLK EN LL L KI DFG+SK S ++ GTP Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 189 LKKEYDG--KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA-IPD-YV 244 + G + D WS GV L++ L G PF + + + +I + +Y IP+ + Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK---DQITSGKYNFIPEVWA 370 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +S + L+ ++ V DP R + E H W Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 >4B6L-A nrPDB Length = 281 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 88/272 (32%), Positives = 133/272 (48%), Gaps = 14/272 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIIN----HRSLRHPNIVRFKE 82 +G G F D ++ AVK I + + + +I+N HR L+H +IVRF Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 76 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 ++ I +E S L E E R++ +Q++SG+ Y H + HRDLK Sbjct: 77 HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLK 136 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLKKEYDGKVADVW 201 L N + + LK+ DFG + Q K T+ GTP Y+APEVLL++ + G ADVW Sbjct: 137 LGNFFI--TENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-GPEADVW 193 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 S G +Y +L G+ PFE + ++T I V Y +P +S R L++ I A Sbjct: 194 SLGCVMYTLLCGSPPFET----ADLKETYRCIKQVHYTLP--ASLSLPARQLLAAILRAS 247 Query: 262 PAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 P R SI +I H++F K D + ++ T Sbjct: 248 PRDRPSIDQILRHDFFTKGYTPDRLPISSCVT 279 >3TAC-A nrPDB Length = 361 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 90/277 (32%), Positives = 145/277 (52%), Gaps = 28/277 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID------ENVKREIINHRSL 72 D YEL + IG G F V R ++++ + AVK ++ + E++KRE L Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML 85 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGEL-FERI--CNAGR-FSEDEARFFFQQLISGV 128 +HP+IV E + L +V E+ G +L FE + +AG +SE A + +Q++ + Sbjct: 86 KHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEAL 145 Query: 129 SYCHAMQVCHRDLKLENTLLDG--SPAPRLKICDFGYS----KSSVLHSQPKSTVGTPAY 182 YCH + HRD+K LL + AP +K+ FG + +S ++ VGTP + Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAP-VKLGGFGVAIQLGESGLVAG---GRVGTPHF 201 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI-- 240 +APEV+ ++ Y GK DVW CGV L+++L G PF +E + I+ +Y + Sbjct: 202 MAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGKYKMNP 255 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 + HIS + L+ R+ + DPA+RI++ E NH W Sbjct: 256 RQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >2OU7-A nrPDB Length = 335 Score = 127 bits (319), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 131/265 (49%), Gaps = 15/265 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPNIVRFKE 82 +G G F + D + E+ A K + + + E + EI HRSL H ++V F Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + +V+E L E +E EAR++ +Q++ G Y H +V HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLKKEYDGKVADVW 201 L N L+ +KI DFG + + K + GTP YIAPEVL KK + +V DVW Sbjct: 169 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV-DVW 225 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 S G +Y +LVG PFE ++T RI +Y+IP HI+P LI ++ D Sbjct: 226 SIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 279 Query: 262 PAKRISIPEIRNHEWFLKN-LPADL 285 P R +I E+ N E+F +PA L Sbjct: 280 PTARPTINELLNDEFFTSGYIPARL 304 >4J52-A nrPDB Length = 293 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 92/265 (34%), Positives = 131/265 (49%), Gaps = 15/265 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPNIVRFKE 82 +G G F + D + E+ A K + + + E + EI HRSL H ++V F Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + +V+E L E +E EAR++ +Q++ G Y H +V HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 143 LENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVW 201 L N L+ +KI DFG +K + K GTP YIAPEVL KK + +V DVW Sbjct: 142 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV-DVW 198 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 S G +Y +LVG PFE ++T RI +Y+IP HI+P LI ++ D Sbjct: 199 SIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 252 Query: 262 PAKRISIPEIRNHEWFLKN-LPADL 285 P R +I E+ N E+F +PA L Sbjct: 253 PTARPTINELLNDEFFTSGYIPARL 277 >4PDS-A nrPDB Length = 347 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 129/264 (48%), Gaps = 16/264 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRFKEVI 84 +G G F + ++ + + +VK I + + I + V RE+ + L HP IVR K Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 98 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 +VME+ SGG+L + + G ED R +Q+++ + Y H+M + HRDLK + Sbjct: 99 EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPD 158 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK-------EYDGK- 196 N L++ +KI FG +K S K+ GT AY+APEV+ K EY+ + Sbjct: 159 NILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERN 218 Query: 197 ----VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 + D+WS G +YV+L G PF + + + K I R + + D+ IS E R Sbjct: 219 EYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLY-KQIGRGSYHEGPLKDF-RISEEARD 276 Query: 253 LISRIFVADPAKRISIPEIRNHEW 276 I + DP R + + NH W Sbjct: 277 FIDSLLQVDPNNRSTAAKALNHPW 300 >4C0T-A nrPDB Length = 974 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 86/273 (31%), Positives = 131/273 (47%), Gaps = 26/273 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE------NVKREIINHRSLRH 74 ++ K++G G++ L DK + + AVK +++ I E N+++ +N S R Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 ++ L V++YAS GEL I +E+ R F Q++ + Y H Sbjct: 328 -GVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDN 386 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGY----------SKSSVLHSQPKSTVGTPAYIA 184 V HRDLK EN LLD R++I DFG S+ + + KS VGT Y++ Sbjct: 387 GVIHRDLKPENILLDD--KMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE LL+ +Y GK DVW+ G +Y M+ G PF+ E F+K P + Sbjct: 445 PE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTII 503 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 R LI +I V P++R +IPEI+ H +F Sbjct: 504 ------RDLIKKILVLQPSRRATIPEIQKHYFF 530 >2I0E-A nrPDB Length = 353 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 20/262 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RHPNIVRFK 81 +G G+FG L K ++EL AVK +++ I D++V+ ++ R L + P + + Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 87 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 T L VMEY +GG+L I GRF E A F+ ++ G+ + + + +RDL Sbjct: 88 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 147 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEYDGKVADV 200 KL+N +LD +KI DFG K ++ K+ GTP YIAPE++ + Y GK D Sbjct: 148 KLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 204 Query: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 W+ GV LY ML G PFE +E + F+ + NV Y +S E + + Sbjct: 205 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAICKGLMTK 258 Query: 261 DPAKRISI-PE----IRNHEWF 277 P KR+ PE I+ H +F Sbjct: 259 HPGKRLGCGPEGERDIKEHAFF 280 >4RA4-A nrPDB Length = 355 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 85/262 (32%), Positives = 133/262 (50%), Gaps = 20/262 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RHPNIVRFK 81 +G G+FG L K + EL A+K +++ I D++V+ ++ R L + P + + Sbjct: 28 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 87 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 T L VMEY +GG+L I G+F E +A F+ ++ G+ + H + +RDL Sbjct: 88 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 147 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEYDGKVADV 200 KL+N +LD +KI DFG K ++ ++ GTP YIAPE++ + Y GK D Sbjct: 148 KLDNVMLDSE--GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDW 204 Query: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 W+ GV LY ML G PF+ +E + F+ + NV Y +S E + + Sbjct: 205 WAYGVLLYEMLAGQPPFDGEDEDELFQSIMEH--NVSYP----KSLSKEAVSICKGLMTK 258 Query: 261 DPAKRISI-PE----IRNHEWF 277 PAKR+ PE +R H +F Sbjct: 259 HPAKRLGCGPEGERDVREHAFF 280 >5FET-A nrPDB Length = 847 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 82/260 (31%), Positives = 125/260 (48%), Gaps = 17/260 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPNIVRFKE 82 IG G FG +L+ K + A+K + + I N + I R + HP I+R Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVR 600 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + E +GGEL++ I G S+ +A+F+ +I + Y H + +RDLK Sbjct: 601 TFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLK 660 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 EN LLD +K+ DFG +K + + + VGTP Y+APEV+L K Y G D+W+ Sbjct: 661 PENILLD--KQGYVKLIDFGCAKK--IQGRAYTLVGTPHYMAPEVILGKGY-GCTVDIWA 715 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 GV LY + G PF + +E + + IL Q PDYV + +L+ R+ P Sbjct: 716 LGVCLYEFICGPLPFGNDQEDQ--LEIFRDILTGQLTFPDYVS-DQDSINLMKRLLCRLP 772 Query: 263 AKRI-----SIPEIRNHEWF 277 RI +I+ H +F Sbjct: 773 QGRIGCSINGFKDIKEHAFF 792 >4JXF-A nrPDB Length = 266 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 79/260 (30%), Positives = 137/260 (52%), Gaps = 15/260 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGE----KIDENVKREIINHRSLRHPNIVRFKE 82 +G G+F + VA+K I++ + + V+ E+ H L+HP+I+ Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 ++ +V+E GE+ + N + FSE+EAR F Q+I+G+ Y H+ + HRDL Sbjct: 75 YFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDL 134 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVL-HSQPKSTVGTPAYIAPEVLLKKEYDGKVADV 200 L N LL + +KI DFG + + H + + GTP YI+PE+ + + G +DV Sbjct: 135 TLSNLLL--TRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDV 191 Query: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 WS G Y +L+G PF D + KN T+++++ Y +P ++ I E + LI ++ Sbjct: 192 WSLGCMFYTLLIGRPPF-DTDTVKN---TLNKVVLADYEMPSFLSI--EAKDLIHQLLRR 245 Query: 261 DPAKRISIPEIRNHEWFLKN 280 +PA R+S+ + +H + +N Sbjct: 246 NPADRLSLSSVLDHPFMSRN 265 >3PFQ-A nrPDB Length = 674 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 20/262 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RHPNIVRFK 81 +G G+FG L K ++EL AVK +++ I D++V+ ++ R L + P + + Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 408 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 T L VMEY +GG+L I GRF E A F+ ++ G+ + + + +RDL Sbjct: 409 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 468 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEYDGKVADV 200 KL+N +LD +KI DFG K ++ K+ GTP YIAPE++ + Y GK D Sbjct: 469 KLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDW 525 Query: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 W+ GV LY ML G PFE +E + F+ + NV Y +S E + + Sbjct: 526 WAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAICKGLMTK 579 Query: 261 DPAKRISI-PE----IRNHEWF 277 P KR+ PE I+ H +F Sbjct: 580 HPGKRLGCGPEGERDIKEHAFF 601 >1KOB-A nrPDB Length = 387 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 130/264 (49%), Gaps = 11/264 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-NVKREIINHRSLRHPNI 77 D Y++++++GSG FGV +K + + K+I +D+ VK EI L HP + Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKL 110 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCHAMQV 136 + + + +++E+ SGGELF+RI + SE E + +Q G+ + H + Sbjct: 111 INLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSI 170 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 H D+K EN + + A +KI DFG + K T T + APE+ + +E G Sbjct: 171 VHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEI-VDREPVGF 229 Query: 197 VADVWSCGVTLYVMLVGAYPF---EDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D+W+ GV YV+L G PF +D E +N ++ + ++ + +SPE + Sbjct: 230 YTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC-----DWEFDEDAFSSVSPEAKDF 284 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 I + +P KR+++ + H W Sbjct: 285 IKNLLQKEPRKRLTVHDALEHPWL 308 >4APC-A nrPDB Length = 350 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 82/274 (29%), Positives = 147/274 (53%), Gaps = 24/274 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 ++Y ++ IG G+FG A L++ + +K I K E +RE+ +++HP Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR---FSEDEARFFFQQLISGVSYCH 132 NIV+++E L IVM+Y GG+LF+RI NA + F ED+ +F Q+ + + H Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRI-NAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 133 AMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEV 187 ++ HRD+K +N L DG+ +++ DFG ++ VL+S ++ +GTP Y++PE+ Sbjct: 143 DRKILHRDIKSQNIFLTKDGT----VQLGDFGIAR--VLNSTVELARACIGTPYYLSPEI 196 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 K Y+ K +D+W+ G LY + + F E + + + +I++ + P +H S Sbjct: 197 CENKPYNNK-SDIWALGCVLYELCTLKHAF----EAGSMKNLVLKIISGSFP-PVSLHYS 250 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 + R L+S++F +P R S+ I + K + Sbjct: 251 YDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRI 284 >6BDL-A nrPDB Length = 347 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 135/267 (50%), Gaps = 17/267 (6%) Query: 21 YELVKDIGSGNFGVARLMRDK-QSNELVAVKYIERGEKIDENVKREIINHRSLRHPN--- 76 + ++ +G G FG L++ K + ++ A+K +++ +D + I + + + Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 77 -IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 IVR +L ++ME GGEL+ + + G F + RF+ ++ +Y H+ Sbjct: 96 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 155 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + +RDLK EN +LD +L DFG++K + + GTP Y+APE++L K +D Sbjct: 156 IIYRDLKPENLILDHRGYAKL--VDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD- 212 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 AD WS G+ +Y +L G+ PF P+ K + + I +++ I+ +LI Sbjct: 213 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP----KKIAKNAANLIK 268 Query: 256 RIFVADPAKRI-----SIPEIRNHEWF 277 ++ +P++R+ + +I+ H+WF Sbjct: 269 KLCRDNPSERLGNLKNGVKDIQKHKWF 295 >4L42-A nrPDB Length = 346 Score = 118 bits (296), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 136/271 (50%), Gaps = 23/271 (8%) Query: 21 YELVKDIGSGNFGVA---RLMRDKQSNELVAVKYIE-----RGEKIDENVKREIINHRSL 72 +EL++ +G G +G R + + ++ A+K ++ R K + K E + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 +HP IV T L +++EY SGGELF ++ G F ED A F+ ++ + + H Sbjct: 80 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 139 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKK 191 + +RDLK EN +L+ +K+ DFG K S+ T GT Y+APE+L++ Sbjct: 140 QKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 197 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 ++ + D WS G +Y ML GA PF +N +KTI +IL + +P Y ++ E R Sbjct: 198 GHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPPY--LTQEAR 250 Query: 252 HLISRIFVADPAKRIS-----IPEIRNHEWF 277 L+ ++ + A R+ E++ H +F Sbjct: 251 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >6E9W-A nrPDB Length = 443 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 91/273 (33%), Positives = 137/273 (50%), Gaps = 26/273 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----RHPN 76 YE+VK IG G FG +L+R K + ++ A+K + + E I + R + P Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 163 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V+ +L +VMEY GG+L + N E ARF+ +++ + H+M Sbjct: 164 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMGF 222 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFG----YSKSSVLHSQPKSTVGTPAYIAPEVLLKK- 191 HRD+K +N LLD S LK+ DFG +K ++ + VGTP YI+PEVL + Sbjct: 223 IHRDVKPDNMLLDKS--GHLKLADFGTCMKMNKEGMVRCD--TAVGTPDYISPEVLKSQG 278 Query: 192 --EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHIS 247 Y G+ D WS GV LY MLVG PF + T +I+N + ++ PD IS Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPF----YADSLVGTYSKIMNHKNSLTFPDDNDIS 334 Query: 248 PECRHLISRIFVADPAKRI---SIPEIRNHEWF 277 E ++LI F+ D R+ + EI+ H +F Sbjct: 335 KEAKNLIC-AFLTDREVRLGRNGVEEIKRHLFF 366 >6QAU-A nrPDB Length = 280 Score = 117 bits (294), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 76/227 (33%), Positives = 118/227 (51%), Gaps = 16/227 (7%) Query: 27 IGSGNFGVARLMRDKQSNEL-VAVKYIERGEKIDENV--KREIINHRSLRHPNIVRFKEV 83 +G G F V R +Q + VA+K I + + +EI + L+H NIV +V Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDV 78 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 P + +VMEY +GG+L + + G SED R F Q+ + + H+ + HRDLK Sbjct: 79 QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKP 138 Query: 144 ENTLLDGS-------PAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVLLKKEYD 194 +N LL + R+KI DFG+++ LHS + G+P Y+APEV++ + YD Sbjct: 139 QNILLSYANRRKSSVSGIRIKIADFGFAR--YLHSNMMAADLCGSPMYMAPEVIMSQHYD 196 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 K AD+WS G +Y LVG PF+ P++ R + ++ +IP Sbjct: 197 AK-ADLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLMPSIP 241 >1VZO-A nrPDB Length = 355 Score = 117 bits (294), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 79/279 (28%), Positives = 140/279 (50%), Gaps = 23/279 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRD---KQSNELVAVKYIERGEKIDE-------NVKREIIN 68 + +EL+K +G+G +G L+R + +L A+K +++ + + +R+++ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 H + P +V T T L ++++Y +GGELF + RF+E E + + +++ + Sbjct: 114 HIR-QSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPE 186 + H + + +RD+KLEN LLD + + + DFG SK V ++ GT Y+AP+ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSN--GHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 187 VLLKKEYD-GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 ++ + K D WS GV +Y +L GA PF E + + RIL + P Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ--E 288 Query: 246 ISPECRHLISRIFVADPAKRISIP-----EIRNHEWFLK 279 +S + LI R+ + DP KR+ EI+ H +F K Sbjct: 289 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >4RLP-A nrPDB Length = 288 Score = 117 bits (292), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 136/271 (50%), Gaps = 23/271 (8%) Query: 21 YELVKDIGSGNFGVA---RLMRDKQSNELVAVKYIE-----RGEKIDENVKREIINHRSL 72 +EL++ +G G +G R + + ++ A+K ++ R K + K E + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 +HP IV T L +++EY SGGELF ++ G F ED A F+ ++ + + H Sbjct: 67 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 126 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKK 191 + +RDLK EN +L+ +K+ DFG K S+ T GT Y+APE+L++ Sbjct: 127 QKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 ++ + D WS G +Y ML GA PF +N +KTI +IL + +P Y ++ E R Sbjct: 185 GHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPPY--LTQEAR 237 Query: 252 HLISRIFVADPAKRIS-----IPEIRNHEWF 277 L+ ++ + A R+ E++ H +F Sbjct: 238 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >3ORZ-A nrPDB Length = 316 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 82/263 (31%), Positives = 128/263 (48%), Gaps = 20/263 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPN 76 ++ K +G G+F L R+ ++ A+K +E+ I EN V RE L HP Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 V+ L + YA GEL + I G F E RF+ +++S + Y H + Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-----STVGTPAYIAPEVLLKK 191 HRDLK EN LL+ ++I DFG +K VL + K S VGT Y++PE+L +K Sbjct: 159 IHRDLKPENILLNED--MHIQITDFGTAK--VLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 K +D+W+ G +Y ++ G PF E F+K I+ ++Y P+ P+ R Sbjct: 215 S-ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK----IIKLEYDFPE--KFFPKAR 267 Query: 252 HLISRIFVADPAKRISIPEIRNH 274 L+ ++ V D KR+ E+ + Sbjct: 268 DLVEKLLVLDATKRLGCEEMEGY 290 >2Y7J-A nrPDB Length = 365 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 80/267 (29%), Positives = 129/267 (48%), Gaps = 21/267 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE---------RGEKIDENVKREI-INHRSLRHPN 76 IG G V R + + AVK +E + E++ E +RE I + HP+ Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I+ + + + + +V + GELF+ + SE E R + L+ VS+ HA + Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNI 221 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD-- 194 HRDLK EN LLD + ++++ DFG+S + + GTP Y+APE+ LK D Sbjct: 222 VHRDLKPENILLDDN--MQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI-LKCSMDET 278 Query: 195 ----GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 GK D+W+CGV L+ +L G+ PF + R + Q++ P++ S Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG--QYQFSSPEWDDRSSTV 336 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWF 277 + LISR+ DP R++ + H +F Sbjct: 337 KDLISRLLQVDPEARLTAEQALQHPFF 363 >1PHK-A nrPDB Length = 298 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 133/286 (46%), Gaps = 24/286 (8%) Query: 12 LPIMHDS----DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI----------ERGEK 57 LP H + + YE + +G G V R K + + AVK I E ++ Sbjct: 6 LPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQE 65 Query: 58 IDENVKREI-INHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE 116 + E +E+ I + HPNI++ K+ T T +V + GELF+ + SE E Sbjct: 66 LREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKE 125 Query: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST 176 R + L+ + H + + HRDLK EN LLD +K+ DFG+S + + Sbjct: 126 TRKIMRALLEVICALHKLNIVHRDLKPENILLDDD--MNIKLTDFGFSCQLDPGEKLREV 183 Query: 177 VGTPAYIAPEVLLKKEYD-----GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH 231 GTP+Y+APE++ D GK D+WS GV +Y +L G+ PF ++ R + Sbjct: 184 CGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMS 243 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 N Q+ P++ S + L+SR V P KR + E H +F Sbjct: 244 G--NYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFF 287 >6DC0-A nrPDB Length = 292 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 72/208 (34%), Positives = 107/208 (51%), Gaps = 13/208 (6%) Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NI EVIL T + E G++ + + R E+EA F+Q++S V++CH Sbjct: 57 HSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 115 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVL-L 189 + DLKL + +L++ + ++ + + G PAY++PE+L Sbjct: 116 SAIVLGDLKLRKFVFSTEERTQLRLESL--EDTHIMKGEDDALSDKHGCPAYVSPEILNT 173 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Y GK ADVWS GV LY +LVG YPF D + F K I Q+ IP+ HISP+ Sbjct: 174 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPK 227 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWF 277 R LI + +P++R++ PEI H WF Sbjct: 228 ARCLIRSLLRREPSERLTAPEILLHPWF 255 >4WNO-A nrPDB Length = 287 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 74/212 (34%), Positives = 112/212 (52%), Gaps = 14/212 (6%) Query: 27 IGSGNFGVARLMRDKQSNEL-VAVKYIERGE--KIDENVKREIINHRSLRHPNIVRFKEV 83 IG G F V R + +++L VAVK I + K + +EI + L+H NIV + Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDF 85 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 + +VMEY +GG+L + + SED R F QQ+ + H+ + HRDLK Sbjct: 86 QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKP 145 Query: 144 ENTLLDGSPAP--------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 +N LL +PA R+KI DFG+++ + + G+P Y+APEV++ + YDG Sbjct: 146 QNILLS-NPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 204 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFR 227 K AD+WS G +Y L G PF+ P++ R Sbjct: 205 K-ADLWSIGTIVYQCLTGKAPFQ-ASSPQDLR 234 >5CEK-A nrPDB Length = 263 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 72/208 (34%), Positives = 107/208 (51%), Gaps = 13/208 (6%) Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NI EVIL T + E G++ + + R E+EA F+Q++S V++CH Sbjct: 60 HSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 118 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVL-L 189 + DLKL + +L++ + ++ + + G PAY++PE+L Sbjct: 119 SAIVLGDLKLRKFVFSTEERTQLRLESL--EDTHIMKGEDDALSDKHGCPAYVSPEILNT 176 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Y GK ADVWS GV LY +LVG YPF D + F K I Q+ IP+ HISP+ Sbjct: 177 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPK 230 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWF 277 R LI + +P++R++ PEI H WF Sbjct: 231 ARCLIRSLLRREPSERLTAPEILLHPWF 258 >3HKO-A nrPDB Length = 345 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 88/311 (28%), Positives = 138/311 (44%), Gaps = 58/311 (18%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE------KIDENVKREIINHRSLR 73 +Y L IG G++GV R+ + Q+ + A+K + + + K E +K E+ + L Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFER--------------------ICNAGRFS 113 HPNI R EV ++ +VME GG L ++ IC + Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 114 ED----------EARFFFQ----------QLISGVSYCHAMQVCHRDLKLENTLLDGSPA 153 E+ E+ F Q Q+ S + Y H +CHRD+K EN L + + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 154 PRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVL-LKKEYDGKVADVWSCGVTL 207 +K+ DFG SK ++ + + GTP ++APEVL E G D WS GV L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 208 YVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPECRHLISRIFVADPAKR 265 +++L+GA PF + TI ++LN + P+Y +SP R L+S + + +R Sbjct: 267 HLLLMGAVPFPGVNDA----DTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDER 322 Query: 266 ISIPEIRNHEW 276 H W Sbjct: 323 FDAMRALQHPW 333 >3A8W-A nrPDB Length = 345 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 146/305 (47%), Gaps = 26/305 (8%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-----GEKIDENV 62 G MD + D ++L++ IG G++ L+R K+++ + A+K +++ E ID Sbjct: 1 GAMDPLGLQD---FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 57 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + + ++ HP +V T + L V+EY +GG+L + + E+ ARF+ Sbjct: 58 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 117 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPA 181 ++ ++Y H + +RDLKL+N LLD +K+ D+G K + ST GTP Sbjct: 118 EISLALNYLHERGIIYRDLKLDNVLLDSE--GHIKLTDYGMCKEGLRPGDTTSTFCGTPN 175 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE-----DPEEPKNFRKTIHRILNV 236 YIAPE+L ++Y G D W+ GV ++ M+ G PF+ D + IL Sbjct: 176 YIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 234 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKRI------SIPEIRNHEWFLKNLPADLMNDNT 290 Q IP +S + ++ DP +R+ +I+ H +F +N+ D+M Sbjct: 235 QIRIPR--SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF-RNVDWDMMEQKQ 291 Query: 291 MTTQF 295 + F Sbjct: 292 VVPPF 296 >2WTK-C nrPDB Length = 305 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 88/278 (31%), Positives = 138/278 (49%), Gaps = 26/278 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-----DENVKREIINHRSLRH 74 +Y + +G G++G + + D ++ AVK +++ + + NVK+EI R LRH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 75 PNIVRFKEVILT--PTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSY 130 N+++ +V+ + +VMEY G E+ + + RF +A +F QLI G+ Y Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGLEY 124 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-----SQPKSTVGTPAYIAP 185 H+ + H+D+K N LL + LKI G +++ LH +++ G+PA+ P Sbjct: 125 LHSQGIVHKDIKPGNLLL--TTGGTLKISALGVAEA--LHPFAADDTCRTSQGSPAFQPP 180 Query: 186 EVLLKKE-YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 E+ + + G D+WS GVTLY + G YPFE N K I YAIP Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGSYAIPG-- 234 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 P L+ + +PAKR SI +IR H WF K P Sbjct: 235 DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 >3FXW-A nrPDB Length = 336 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 89/311 (28%), Positives = 150/311 (48%), Gaps = 17/311 (5%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHP 75 +D Y+L K + G G G +++ + A+K + K ++E+ +H ++ P Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK----ARQEVDHHWQASGGP 82 Query: 76 NIVRFKEVILTPTH----LAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVS 129 +IV +V H L I+ME GGELF RI G F+E EA + + + + Sbjct: 83 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 130 YCHAMQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + H+ + HRD+K EN L LK+ DFG++K + ++ ++ TP Y+APEVL Sbjct: 143 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCYTPYYVAPEVL 201 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHI 246 ++YD K D+WS GV +Y++L G PF RI QY P ++ + Sbjct: 202 GPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEV 260 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIE 306 S + + LI + DP +R++I + NH W +++ +T ++ D + E Sbjct: 261 SEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKE 320 Query: 307 EIMQIIAEATV 317 E+ +A V Sbjct: 321 EMTSALATMRV 331 >6ED6-A nrPDB Length = 415 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 87/276 (31%), Positives = 139/276 (50%), Gaps = 26/276 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----R 73 ++ Y++VK IG G FG +L+R K S ++ A+K + + E I + R + Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 146 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 P +V+ +L +VMEY GG+L + N E A+F+ +++ + H+ Sbjct: 147 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHS 205 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFG----YSKSSVLHSQPKSTVGTPAYIAPEVLL 189 M + HRD+K +N LLD LK+ DFG ++ ++H + VGTP YI+PEVL Sbjct: 206 MGLIHRDVKPDNMLLDKH--GHLKLADFGTCMKMDETGMVHCD--TAVGTPDYISPEVLK 261 Query: 190 KKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYV 244 + D G+ D WS GV LY MLVG PF + T +I++ + ++ P+ Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPF----YADSLVGTYSKIMDHKNSLCFPEDA 317 Query: 245 HISPECRHLISRIFVADPAKRI---SIPEIRNHEWF 277 IS ++LI F+ D R+ + EIR H +F Sbjct: 318 EISKHAKNLIC-AFLTDREVRLGRNGVEEIRQHPFF 352 >4XBR-A nrPDB Length = 366 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 135/260 (51%), Gaps = 13/260 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V L Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 161 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L +VME+ GG L + I R +E++ ++ +S HA V HRD+K ++ Sbjct: 162 VGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 220 Query: 146 TLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 221 ILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 275 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 G+ + M+ G P+ + E P K I N+ + + +SP + + R+ V DP Sbjct: 276 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRD--NLPPRLKNLHKVSPSLKGFLDRLLVRDP 332 Query: 263 AKRISIPEIRNHEWFLKNLP 282 A+R + E+ H + K P Sbjct: 333 AQRATAAELLKHPFLAKAGP 352 >2Q0N-A nrPDB Length = 301 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 135/260 (51%), Gaps = 13/260 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V L Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 96 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L +VME+ GG L + I R +E++ ++ +S HA V HRD+K ++ Sbjct: 97 VGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 155 Query: 146 TLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 156 ILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 210 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 G+ + M+ G P+ + E P K I N+ + + +SP + + R+ V DP Sbjct: 211 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRD--NLPPRLKNLHKVSPSLKGFLDRLLVRDP 267 Query: 263 AKRISIPEIRNHEWFLKNLP 282 A+R + E+ H + K P Sbjct: 268 AQRATAAELLKHPFLAKAGP 287 >4KS7-A nrPDB Length = 292 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 81/261 (31%), Positives = 139/261 (53%), Gaps = 19/261 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ L R+K S VAVK ++ R ++ E + E++ R +H N+V + L Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 90 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L ++ME+ GG L + I + R +E++ + ++ ++Y HA V HRD+K ++ Sbjct: 91 VGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDS 149 Query: 146 TL--LDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 L LDG R+K+ DFG+ ++ S + KS VGTP ++APEV+ + Y +V D+WS Sbjct: 150 ILLTLDG----RVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEV-DIWS 204 Query: 203 CGVTLYVMLVGAYPF--EDPEEP-KNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFV 259 G+ + M+ G P+ + P + K R + L + +SP R + R+ V Sbjct: 205 LGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSH------KVSPVLRDFLERMLV 258 Query: 260 ADPAKRISIPEIRNHEWFLKN 280 DP +R + E+ +H + L+ Sbjct: 259 RDPQERATAQELLDHPFLLQT 279 >4JDH-A nrPDB Length = 346 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 135/260 (51%), Gaps = 13/260 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V L Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 141 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L +VME+ GG L + I R +E++ ++ +S HA V HRD+K ++ Sbjct: 142 VGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 200 Query: 146 TLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 201 ILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 255 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 G+ + M+ G P+ + E P K I N+ + + +SP + + R+ V DP Sbjct: 256 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRD--NLPPRLKNLHKVSPSLKGFLDRLLVRDP 312 Query: 263 AKRISIPEIRNHEWFLKNLP 282 A+R + E+ H + K P Sbjct: 313 AQRATAAELLKHPFLAKAGP 332 >4FIE-A nrPDB Length = 423 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 135/260 (51%), Gaps = 13/260 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V L Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 218 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L +VME+ GG L + I R +E++ ++ +S HA V HRD+K ++ Sbjct: 219 VGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 277 Query: 146 TLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 278 ILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWS 332 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 G+ + M+ G P+ + E P K I N+ + + +SP + + R+ V DP Sbjct: 333 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRD--NLPPRLKNLHKVSPSLKGFLDRLLVRDP 389 Query: 263 AKRISIPEIRNHEWFLKNLP 282 A+R + E+ H + K P Sbjct: 390 AQRATAAELLKHPFLAKAGP 409 >3LM0-A nrPDB Length = 327 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 74/263 (28%), Positives = 125/263 (47%), Gaps = 16/263 (6%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREI-INHRSLRHPNIVRF 80 K++G G F V R K + + A K+++ RG+ + EI + + P ++ Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 81 KEVILTPTHLAIVMEYASGGELFERICN---AGRFSEDEARFFFQQLISGVSYCHAMQVC 137 EV + + +++EYA+GGE+F +C A SE++ +Q++ GV Y H + Sbjct: 95 HEVYENTSEIILILEYAAGGEIFS-LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIV 153 Query: 138 HRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD-- 194 H DLK +N LL P +KI DFG S+ + + +GTP Y+APE+L YD Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL---NYDPI 210 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 D+W+ G+ Y++L PF + + + +NV Y+ + +S I Sbjct: 211 TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQ--VNVDYSEETFSSVSQLATDFI 268 Query: 255 SRIFVADPAKRISIPEIRNHEWF 277 + V +P KR + +H W Sbjct: 269 QSLLVKNPEKRPTAEICLSHSWL 291 >6E2O-A nrPDB Length = 295 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 78/245 (31%), Positives = 125/245 (51%), Gaps = 10/245 (4%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYI-ERGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G +G+ RD + +A+K I ER + + + EI H+ L+H NIV++ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 89 Query: 86 TPTHLAIVMEYASGGELFERI-CNAGRFSEDEAR--FFFQQLISGVSYCHAMQVCHRDLK 142 + I ME GG L + G ++E F+ +Q++ G+ Y H Q+ HRD+K Sbjct: 90 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 149 Query: 143 LENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKKEYD-GKVADV 200 +N L++ + + LKI DFG SK + ++ ++ GT Y+APE++ K GK AD+ Sbjct: 150 GDNVLIN-TYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 208 Query: 201 WSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 WS G T+ M G PF + EP+ + + V IP+ +S E + I + F Sbjct: 209 WSLGCTIIEMATGKPPFYELGEPQAAMFKVG-MFKVHPEIPE--SMSAEAKAFILKCFEP 265 Query: 261 DPAKR 265 DP KR Sbjct: 266 DPDKR 270 >4EQM-A nrPDB Length = 294 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 104/206 (50%), Gaps = 9/206 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI----ERGEKIDENVKREIINHRSLR 73 ++RY++V +G G L D N VA+K I E+ + +RE+ N L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NIV +V +VMEY G L E I + G S D A F Q++ G+ + H Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHD 129 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKK 191 M++ HRD+K +N L+D + LKI DFG +K S +Q +GT Y +PE K Sbjct: 130 MRIVHRDIKPQNILIDSNKT--LKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAKG 186 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPF 217 E + D++S G+ LY MLVG PF Sbjct: 187 EATDECTDIYSIGIVLYEMLVGEPPF 212 >3DLS-A nrPDB Length = 335 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 127/270 (47%), Gaps = 26/270 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----------VKREII 67 S +Y + +GSG FG DK+ N+ V VK+I++ EK+ E+ V EI Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKK-EKVLEDCWIEDPKLGKVTLEIA 81 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVME-YASGGELFERICNAGRFSEDEARFFFQQLIS 126 + H NI++ ++ +VME + SG +LF I R E A + F+QL+S Sbjct: 82 ILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVS 141 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 V Y + HRD+K EN ++ + +K+ DFG + + GT Y APE Sbjct: 142 AVGYLRLKDIIHRDIKDENIVI--AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPE 199 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 VL+ Y G ++WS GVTLY ++ PF + EE IH P Y+ + Sbjct: 200 VLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEE--TVEAAIH---------PPYL-V 247 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEW 276 S E L+S + P +R ++ ++ W Sbjct: 248 SKELMSLVSGLLQPVPERRTTLEKLVTDPW 277 >4X7Q-B nrPDB Length = 312 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 79/270 (29%), Positives = 117/270 (43%), Gaps = 28/270 (10%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIIN-----------H 69 Y L +G G FG VA+K I R + + + + Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 92 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYA-SGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP ++R + T +V+E +LF+ I G E +R FF Q+++ + Sbjct: 93 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 152 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEV 187 +CH+ V HRD+K EN L+D K+ DFG ++LH +P + GT Y PE Sbjct: 153 QHCHSRGVVHRDIKDENILIDLRRG-CAKLIDFG--SGALLHDEPYTDFDGTRVYSPPEW 209 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + + +Y A VWS G+ LY M+ G PFE +E IL + P H+S Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE----------ILEAELHFP--AHVS 257 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWF 277 P+C LI R P+ R S+ EI W Sbjct: 258 PDCCALIRRCLAPKPSSRPSLEEILLDPWM 287 >4CRS-A nrPDB Length = 341 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 86/261 (32%), Positives = 133/261 (50%), Gaps = 23/261 (8%) Query: 30 GNFGVARLMRDKQSNELVAVKYIERGEKIDEN-------VKREIINHRSLRHPNIVRFKE 82 G+FG L K +NE+ A+K +++G+ + + KR S+RHP +V Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 82 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 T H+ VMEYA+GG+L I + FSE A F+ ++ G+ Y H ++ +RDLK Sbjct: 83 CFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLK 141 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYDGKVADVW 201 L+N LLD +KI DFG K + + ST GTP ++APEVL + Y + D W Sbjct: 142 LDNLLLDTEGF--VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYT-RAVDWW 198 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 GV +Y MLVG PF +E + F I+N + P + +S E ++ R+ + Sbjct: 199 GLGVLIYEMLVGESPFPGDDEEEVF----DSIVNDEVRYPRF--LSTEAISIMRRLLRRN 252 Query: 262 PAKRISIPE-----IRNHEWF 277 P +R+ E ++ H +F Sbjct: 253 PERRLGASEKDAEDVKKHPFF 273 >4RC3-A nrPDB Length = 289 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 83/267 (31%), Positives = 121/267 (45%), Gaps = 24/267 (8%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREII--NHR 70 +Y++ +GSG FG N VA+K++E+ D V E++ Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 129 S ++R + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 132 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 +CH V HRD+K EN L+D + LK+ DFG S + + + GT Y PE + Sbjct: 133 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Y G+ A VWS G+ LY M+ G PFE EE I+ Q V S E Sbjct: 191 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQRV--SSE 238 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEW 276 C+HLI P+ R + EI+NH W Sbjct: 239 CQHLIRWCLALRPSDRPTFEEIQNHPW 265 >5TUR-A nrPDB Length = 404 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/273 (31%), Positives = 123/273 (45%), Gaps = 34/273 (12%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREII--NHR 70 +Y++ +GSG FG N VA+K++E+ D V E++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 129 S ++R + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 247 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTPAYIA 184 +CH V HRD+K EN L+D + LK+ DFG ++L K TV GT Y Sbjct: 248 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG--SGALL----KDTVYTDFDGTRVYSP 300 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE + Y G+ A VWS G+ LY M+ G PFE EE I+ Q V Sbjct: 301 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQRV 350 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 S EC+HLI P+ R + EI+NH W Sbjct: 351 --SSECQHLIRWCLALRPSDRPTFEEIQNHPWM 381 >3BGP-A nrPDB Length = 333 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/272 (31%), Positives = 124/272 (45%), Gaps = 34/272 (12%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREIINHRSL 72 +Y++ +GSG FG N VA+K++E+ D V E++ + + Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 73 R--HPNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 129 ++R + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 176 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTPAYIA 184 +CH V HRD+K EN L+D + LK+ DFG ++L K TV GT Y Sbjct: 177 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG--SGALL----KDTVYTDFDGTRVYSP 229 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE + Y G+ A VWS G+ LY M+ G PFE EE I+ Q V Sbjct: 230 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQRV 279 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEW 276 S EC+HLI P+ R + EI+NH W Sbjct: 280 --SSECQHLIRWCLALRPSDRPTFEEIQNHPW 309 >4OTD-A nrPDB Length = 341 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 83/258 (32%), Positives = 131/258 (50%), Gaps = 18/258 (6%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-------VKREIINHRSLR 73 ++ + +G G+FG L + S EL A+K +++G+ + + KR + S Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAG 73 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HP +V TP H+ VMEY++GG+L I ++ FSE A F+ ++ G+ + H Sbjct: 74 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSACVVLGLQFLHE 132 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKE 192 ++ +RDLKL+N LL +KI DFG K + + ST GTP ++APEVL Sbjct: 133 HKIVYRDLKLDNLLL--DTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 190 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y + D W GV LY MLVG PF +E + F I+N + P + +S E Sbjct: 191 YT-RAVDWWGLGVLLYEMLVGESPFPGDDEEEVF----DSIVNDEVRYPRF--LSAEAIG 243 Query: 253 LISRIFVADPAKRISIPE 270 ++ R+ +P +R+ E Sbjct: 244 IMRRLLRRNPERRLGSSE 261 >5LOH-A nrPDB Length = 341 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 74/271 (27%), Positives = 130/271 (47%), Gaps = 21/271 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----RH 74 + + +VK I G FG ++ ++ +L AVK +++ + I++N+ ++ R + Sbjct: 36 EEFSIVKPISRGAFG--KVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P IV + + ++ +VMEY GG++ + G F E+ A + ++ + Y H Sbjct: 94 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 153 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-------QPKSTVGTPAYIAPEV 187 + HRDLK +N L+ S +K+ DFG SK ++ ++ GTP Y+APE+ Sbjct: 154 GIIHRDLKPDNMLI--SNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPEL 211 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH-I 246 LL + + G D W+ GV L+ L G PF D E P ++ IL P+ + Sbjct: 212 LLGRAH-GPAVDWWALGVCLFEFLTGIPPFND-ETP---QQVFQNILKRDIPWPEGEEKL 266 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 S + + + D KR + E++ H F Sbjct: 267 SDNAQSAVEILLTIDDTKRAGMKELKRHPLF 297 >3M42-A nrPDB Length = 299 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 133/273 (48%), Gaps = 37/273 (13%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 D Y++ + G G G + +K++ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 72 Query: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K T G Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---------TTG----------- 172 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 173 -EKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 230 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 E + LI + +P +R++I E NH W +++ Sbjct: 231 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 263 >6BXI-A nrPDB Length = 333 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 138/304 (45%), Gaps = 57/304 (18%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPN 76 +E +K IG G FG RL++ K + + A+K + + + +++ I R + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V+ +L ++ME+ GG++ + +E+E +F+ + + + H + Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF 127 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKS-----------SVLHSQPK----------- 174 HRD+K +N LLD +K+ DFG ++ HS P Sbjct: 128 IHRDIKPDNLLLDSK--GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 175 --------------STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF--E 218 STVGTP YIAPEV ++ Y+ K+ D WS GV +Y ML+G PF E Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSE 244 Query: 219 DPEEPKNFRKTIHRILNVQ--YAIPDYVHISPECRHLISRIFVADPAKRISIP---EIRN 273 P+E T +++N + P V IS + + LI R F + RI P EI++ Sbjct: 245 TPQE------TYKKVMNWKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGAPGVEEIKS 297 Query: 274 HEWF 277 + +F Sbjct: 298 NSFF 301 >4BGQ-A nrPDB Length = 304 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 65/196 (33%), Positives = 103/196 (52%), Gaps = 12/196 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 +++E++ +G G +GV R K+++E+VA+K E E++ E RE+ R+L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 NIV KE L +V EY EL E + N ++ + + QLI + +CH Sbjct: 72 NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCHK 129 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKK 191 + HRD+K EN L+ + LK+CDFG+++ S ++ V T Y +PE+LL Sbjct: 130 NDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 192 EYDGKVADVWSCGVTL 207 Y GK D+WS G L Sbjct: 188 PY-GKSVDMWSVGCIL 202 >2BPM-A nrPDB Length = 309 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 138/293 (47%), Gaps = 38/293 (12%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLR 73 D + ++ V+ IG G +GV R+K + E+VA+K I E + REI + L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 64 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSY 130 HPNIV+ +VI T L +V E+ + ++ +A + + + QL+ G+++ Sbjct: 65 HPNIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 122 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLL 189 CH+ +V HRDLK +N L++ A +K+ DFG +++ + + + V T Y APE+LL Sbjct: 123 CHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFE-DPEEPKNFRKTIHRILNV------------ 236 +Y D+WS G M+ F D E + FR I R L Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR--IFRTLGTPDEVVWPGVTSM 238 Query: 237 --------QYAIPDYVHISP----ECRHLISRIFVADPAKRISIPEIRNHEWF 277 ++A D+ + P + R L+S++ DP KRIS H +F Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 291 >6GU6-A nrPDB Length = 302 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 85/290 (29%), Positives = 137/290 (47%), Gaps = 39/290 (13%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK----REIINHRSLRHPN 76 Y ++ IG G +GV R K + ++VA+K I R E +E V REI + LRHPN Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 67 Query: 77 IVRFKEVILTPTHLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 IV ++V++ + L ++ E+ S + + I + + Q++ G+ +CH+ Sbjct: 68 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 127 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLKKEY 193 +V HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 128 RVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 194 DGKVADVWSCGVTLYVMLVGAYPF--EDPEEPKNFRKTIHRILNVQY--------AIPDY 243 D+WS G T++ L P D E + FR I R L ++ DY Sbjct: 186 YSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFR--IFRALGTPNNEVWPEVESLQDY 242 Query: 244 VHISPECR----------------HLISRIFVADPAKRISIPEIRNHEWF 277 + P+ + L+S++ + DPAKRIS NH +F Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >3Q53-A nrPDB Length = 306 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 128/264 (48%), Gaps = 14/264 (5%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIV 78 +Y + IG G G D + + VA++ + + + E + EI+ R ++PNIV Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV 81 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + + L L +VMEY +GG L + + E + ++ + + + H+ QV H Sbjct: 82 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIH 140 Query: 139 RDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYDG 195 RD+K +N LL DGS +K+ DFG+ +ST VGTP ++APEV+ +K Y Sbjct: 141 RDIKSDNILLGMDGS----VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 196 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 KV D+WS G+ M+ G P+ + E P R N + + +S R ++ Sbjct: 197 KV-DIWSLGIMAIEMIEGEPPYLN-ENP--LRALYLIATNGTPELQNPEKLSAIFRDFLN 252 Query: 256 RIFVADPAKRISIPEIRNHEWFLK 279 R D KR S E+ H+ FLK Sbjct: 253 RCLEMDVEKRGSAKELIQHQ-FLK 275 >1TKI-A nrPDB Length = 321 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 68/268 (25%), Positives = 123/268 (45%), Gaps = 12/268 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 ++Y + +D+G G FG+ + S + K+++ VK+EI RH NI+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNIL 64 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 E + L ++ E+ SG ++FERI +A +E E + Q+ + + H+ + Sbjct: 65 HLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIG 124 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD--G 195 H D++ EN + + +KI +FG ++ + P Y APEV ++D Sbjct: 125 HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV---HQHDVVS 181 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHISPECRHL 253 D+WS G +YV+L G PF + ++ I I+N +Y + + IS E Sbjct: 182 TATDMWSLGTLVYVLLSGINPF----LAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 237 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNL 281 + R+ V + R++ E H W + + Sbjct: 238 VDRLLVKERKSRMTASEALQHPWLKQKI 265 >2F57-A nrPDB Length = 317 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 79/257 (30%), Positives = 132/257 (51%), Gaps = 14/257 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G+ G+ + +K + + VAVK ++ R ++ E + E++ R H N+V L Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 112 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L +VME+ GG L + I R +E++ ++ +SY H V HRD+K ++ Sbjct: 113 VGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDS 171 Query: 146 TLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 LL DG R+K+ DFG+ ++ S + KS VGTP ++APEV+ + Y G D+WS Sbjct: 172 ILLTSDG----RIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWS 226 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADP 262 G+ + M+ G P+ + E P + I L + + D +S R + + V +P Sbjct: 227 LGIMVIEMIDGEPPYFN-EPPLQAMRRIRDSLPPR--VKDLHKVSSVLRGFLDLMLVREP 283 Query: 263 AKRISIPEIRNHEWFLK 279 ++R + E+ H FLK Sbjct: 284 SQRATAQELLGHP-FLK 299 >3GC0-A nrPDB Length = 329 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 90/295 (30%), Positives = 129/295 (43%), Gaps = 36/295 (12%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK----REIINHRSLRH 74 DRY + +G G +G D +NE VA+K I R E +E V RE+ + L+H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRI-RLEHEEEGVPGTAIREVSLLKELQH 92 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 NI+ K VI L ++ EYA +L + + S + F QLI+GV++CH+ Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSR 151 Query: 135 QVCHRDLKLENTLL---DGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLK 190 + HRDLK +N LL D S P LKI DFG +++ + Q + T Y PE+LL Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLG 211 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ--------YAIPD 242 + D+WS ML+ F E K I +L + A+PD Sbjct: 212 SRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFK-IFEVLGLPDDTTWPGVTALPD 270 Query: 243 YVHISPECR-HLISRIFVA----------------DPAKRISIPEIRNHEWFLKN 280 + P+ R + R+ A DP KRIS H +F N Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHN 325 >5J5T-A nrPDB Length = 370 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 93/360 (25%), Positives = 160/360 (44%), Gaps = 26/360 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPNIV 78 +EL++ IGSG +G R+ + EL A+K I E GE V++EII + +HPNIV Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF-AVVQQEIIMMKDCKHPNIV 64 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + L L I ME+ GG L + G SE + + ++ + G+ Y H+ H Sbjct: 65 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 124 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKKEYDG-- 195 RD+K N LL + +K+ DFG S + ++ K+ +GTP ++APEV + G Sbjct: 125 RDIKGANILLTDN--GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP---DYVHISPECRH 252 ++ D+W+ G+T + P D + + + + P D + S H Sbjct: 183 QLCDLWAVGITAIELAELQPPMFDLHP----MRALFLMTKSNFQPPKLKDKMKWSNSFHH 238 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADL-------MNDNTMTTQFDESDQPGQSI 305 + +P KR + ++ H + ++L L +N+ +T D D + + Sbjct: 239 FVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPL 298 Query: 306 EEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLE--SDLDDLD--IDSSGEIVYA 361 + I + + + G + D + ++ E +L D D +DSS EI Y Sbjct: 299 VAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYT 358 >4AU8-A nrPDB Length = 296 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 134/289 (46%), Gaps = 32/289 (11%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRH 74 S +YE ++ IG G +G ++++++E+VA+K + + E + + REI + L+H Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 NIVR +V+ + L +V E+ + + CN G + + F QL+ G+ +CH+ Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKE 192 V HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL + Sbjct: 124 RNVLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------QYAIPDY- 243 D+WS G + P + + K I R+L +PDY Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 244 -----------VHISPEC----RHLISRIFVADPAKRISIPEIRNHEWF 277 V++ P+ R L+ + +P +RIS E H +F Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >6FD3-A nrPDB Length = 300 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 127/264 (48%), Gaps = 14/264 (5%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIV 78 +Y + IG G G D + + VA+K + + + E + EI+ R ++PNIV Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 82 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + + L L +VMEY +GG L + + E + ++ + + + H+ QV H Sbjct: 83 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIH 141 Query: 139 RDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKEYDG 195 RD+K +N LL DGS +K+ DFG+ +ST VGTP ++APEV+ +K Y Sbjct: 142 RDIKSDNILLGMDGS----VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 197 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 KV D+WS G+ M+ G P+ + E P R N + + +S R ++ Sbjct: 198 KV-DIWSLGIMAIEMVEGEPPYLN-ENP--LRALYLIATNGTPELQNPERLSAVFRDFLN 253 Query: 256 RIFVADPAKRISIPEIRNHEWFLK 279 R D +R S E+ H FLK Sbjct: 254 RCLEMDVDRRGSAKELLQHP-FLK 276 >6CQF-A nrPDB Length = 297 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 61/193 (31%), Positives = 106/193 (54%), Gaps = 8/193 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINHRSLRHPNI 77 D Y+L++ +G G +G RDK S +LVA+K ++ D +++EI+ ++ RH NI Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANI 75 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 V + L L I ME+ G L + G SE + + ++++ G++Y H+ + Sbjct: 76 VAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKI 135 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE---VLLKKEY 193 HRD+K N L++ A +++ DFG S ++ + +GTP ++APE V LK Y Sbjct: 136 HRDIKGANILIN--DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 194 DGKVADVWSCGVT 206 + ++ D+WS G+T Sbjct: 194 N-ELCDIWSLGIT 205 >2XNP-A nrPDB Length = 279 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/272 (30%), Positives = 131/272 (48%), Gaps = 35/272 (12%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPN 76 YE++ IG+G++G + +R K +++ K ++ G + E K+ +++ R L+HPN Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYG-SMTEAEKQMLVSEVNLLRELKHPN 66 Query: 77 IVRFKEVIL--TPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSY 130 IVR+ + I+ T T L IVMEY GG+L I + E+ QL + Sbjct: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126 Query: 131 CH-----AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH---SQPKSTVGTPAY 182 CH V HRDLK N LDG +K+ DFG ++ +L+ S K+ VGTP Y Sbjct: 127 CHRRSDGGHTVLHRDLKPANVFLDGK--QNVKLGDFGLAR--ILNHDTSFAKTFVGTPYY 182 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYP---FEDPEEPKNFRKTIHRILNVQYA 239 ++PE + + Y+ K +D+WS G LY + P F E R+ R + +Y Sbjct: 183 MSPEQMNRMSYNEK-SDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY- 240 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEI 271 S E +I+R+ R S+ EI Sbjct: 241 -------SDELNEIITRMLNLKDYHRPSVEEI 265 >4UYA-A nrPDB Length = 340 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/220 (34%), Positives = 108/220 (49%), Gaps = 21/220 (9%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-----ENVKREII 67 P+ +R EL + IG+G FG ++ R + VAVK + + D E+V+RE Sbjct: 20 PVHVAFERLELKELIGAGGFG--QVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREAR 77 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 LRHPNI+ + V L HL +V+E+A GG L R R + Q+ G Sbjct: 78 LFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARG 136 Query: 128 VSYCHA---MQVCHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPK-STV 177 + Y H + + HRDLK N LL D LKI DFG ++ H K +T Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--WHRTTKMATA 194 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 G A++APEV +K K +D+WS GV L+ +L G P+ Sbjct: 195 GAYAWMAPEV-IKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >3PPZ-A nrPDB Length = 309 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 24/257 (9%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPNIVRFKE 82 IG+G+FG R + VAVK + E+++E + RE+ + LRHPNIV F Sbjct: 45 IGAGSFGTVH--RAEWHGSDVAVKILMEQDFHAERVNEFL-REVAIMKRLRHPNIVLFMG 101 Query: 83 VILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQ--LISGVSYCHAMQ--VC 137 + P +L+IV EY S G L+ + +G R DE R + G++Y H + Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIV 161 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 HRDLK N L+D +K+CDFG S+ S+ L S KS GTP ++APEV L+ E Sbjct: 162 HRDLKSPNLLVDKKYT--VKVCDFGLSRLKASTFLSS--KSAAGTPEWMAPEV-LRDEPS 216 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 + +DV+S GV L+ + P+ + + + ++ IP +++P+ +I Sbjct: 217 NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLE--IPR--NLNPQVAAII 272 Query: 255 SRIFVADPAKRISIPEI 271 + +P KR S I Sbjct: 273 EGCWTNEPWKRPSFATI 289 >2HW6-A nrPDB Length = 307 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 86/294 (29%), Positives = 130/294 (44%), Gaps = 31/294 (10%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-VKREIIN-HRSLRHP 75 D Y+L ++ G G + + Q+ + AVK IE+ + V RE+ ++ + Sbjct: 12 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 NI+ E T +V E GG + I F+E EA + + + + + H Sbjct: 72 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 136 VCHRDLKLENTLLDGSP--APRLKICDFGYSKSSVLH------SQPKSTV--GTPAYIAP 185 + HRDLK EN L + SP +KICDF L+ + P+ T G+ Y+AP Sbjct: 132 IAHRDLKPENILCE-SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAP 190 Query: 186 EVLL----KKEYDGKVADVWSCGVTLYVMLVGAYPF---------EDPEEPKNF--RKTI 230 EV+ + + K D+WS GV LY+ML G PF D E K Sbjct: 191 EVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLF 250 Query: 231 HRILNVQYAIP--DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 I +Y P D+ HIS E + LIS++ V D +R+S ++ H W P Sbjct: 251 ESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 304 >1U5R-A nrPDB Length = 348 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 131/280 (46%), Gaps = 21/280 (7%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNIVR 79 +++IG G+FG RD +++E+VA+K + K ++II + LRHPN ++ Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 80 FKEVILTPTHLAIVMEY--ASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 ++ L +VMEY S +L E + E E + G++Y H+ + Sbjct: 119 YRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 176 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---KKEYD 194 HRD+K N LL S +K+ DFG S+ + + S VGTP ++APEV+L + +YD Sbjct: 177 HRDVKAGNILL--SEPGLVKLGDFG---SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 231 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 GKV DVWS G+T + L P P N ++ I + H S R+ + Sbjct: 232 GKV-DVWSLGITC-IELAERKP---PLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFV 286 Query: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 P R + + H + L+ P ++ D T+ Sbjct: 287 DSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTK 326 >2GCD-A nrPDB Length = 309 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 131/280 (46%), Gaps = 21/280 (7%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNIVR 79 +++IG G+FG RD +++E+VA+K + K ++II + LRHPN ++ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 80 FKEVILTPTHLAIVMEY--ASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 ++ L +VMEY S +L E + E E + G++Y H+ + Sbjct: 80 YRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 137 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---KKEYD 194 HRD+K N LL S +K+ DFG S+ + + S VGTP ++APEV+L + +YD Sbjct: 138 HRDVKAGNILL--SEPGLVKLGDFG---SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 192 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 GKV DVWS G+T + L P P N ++ I + H S R+ + Sbjct: 193 GKV-DVWSLGITC-IELAERKP---PLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFV 247 Query: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 P R + + H + L+ P ++ D T+ Sbjct: 248 DSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTK 287 >3DAK-A nrPDB Length = 290 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 86/291 (29%), Positives = 135/291 (46%), Gaps = 28/291 (9%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINH 69 LP + D YEL + IGSG V + E VA+K I E+ + + + +EI Sbjct: 3 LPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAM 62 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN--------AGRFSEDEARFFF 121 HPNIV + + L +VM+ SGG + + I + +G E Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSK-----SSVLHSQPK 174 ++++ G+ Y H HRD+K N LL DGS ++I DFG S + ++ + Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGS----VQIADFGVSAFLATGGDITRNKVR 178 Query: 175 ST-VGTPAYIAPEVLLK-KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 T VGTP ++APEV+ + + YD K AD+WS G+T + GA P+ K T+ Sbjct: 179 KTFVGTPCWMAPEVMEQVRGYDFK-ADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN 237 Query: 233 -ILNVQYAIPDYVHI---SPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +++ + D + R +IS DP KR + E+ H++F K Sbjct: 238 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >5UUU-A nrPDB Length = 547 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 87/309 (28%), Positives = 132/309 (42%), Gaps = 43/309 (13%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKREIINHRSLRHPNIVR 79 IG G FG R + ++ A+K +++ GE + N + + + P IV Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + H V +R Sbjct: 266 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 325 Query: 140 DLKLENTLLDGSPAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 DLK N LLD R+ CDF K P ++VGT Y+APEVL K Sbjct: 326 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 378 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 AD +S G L+ +L G PF + K+ + L + +PD SPE R L+ Sbjct: 379 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLE 435 Query: 256 RIFVADPAKRISI-----------PEIRNHEW---FLKNLPADLM--------NDNTMTT 293 + D +R+ P R+ +W FL+ P L+ D Sbjct: 436 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIG 495 Query: 294 QFDESDQPG 302 FDE D G Sbjct: 496 SFDEEDTKG 504 >2UV2-A nrPDB Length = 325 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 112/206 (54%), Gaps = 15/206 (7%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLR 73 ++ D +E++ ++G G FG ++K+++ L A K I+ + E+ E+ EI S Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCD 92 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCH 132 HPNIV+ + +L I++E+ +GG + + R +E + + +Q + ++Y H Sbjct: 93 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 133 AMQVCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLL 189 ++ HRDLK N L LDG +K+ DFG S + Q + S +GTP ++APEV++ Sbjct: 153 DNKIIHRDLKAGNILFTLDGD----IKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM 208 Query: 190 -----KKEYDGKVADVWSCGVTLYVM 210 + YD K ADVWS G+TL M Sbjct: 209 CETSKDRPYDYK-ADVWSLGITLIEM 233 >3TKU-A nrPDB Length = 433 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 88/319 (27%), Positives = 150/319 (47%), Gaps = 49/319 (15%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE------NVKREIIN 68 +H D +E++K IG G FG +++ K + + A+K + + E + +R+++ Sbjct: 87 LHRED-FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV 145 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISG 127 + + + + HL +VM+Y GG+L + + ED ARF+ +++ Sbjct: 146 NGDCQWITALHY--AFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLA 203 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPR-------LKICDFGYSKSSVLHSQPKSTVGTP 180 + H + HRD+K +N LLD + R LK+ D G +SSV VGTP Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSV-------AVGTP 256 Query: 181 AYIAPEVLLKKEYD----GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 YI+PE+L E G D WS GV +Y ML G PF ++ +T +I+N Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF----YAESLVETYGKIMNH 312 Query: 237 Q--YAIPDYV-HISPECRHLISRIFVADPAKRI---SIPEIRNHEWF-------LKNLPA 283 + + P +V +S E + LI R+ + +R+ I + + H +F ++NL A Sbjct: 313 EERFQFPSHVTDVSEEAKDLIQRL-ICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEA 371 Query: 284 DLMNDNTM---TTQFDESD 299 + D + T+ FD D Sbjct: 372 PYIPDVSSPSDTSNFDVDD 390 >3PVW-A nrPDB Length = 695 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 131/309 (42%), Gaps = 43/309 (13%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-------PNIVR 79 IG G FG R + ++ A+K +++ + + +N R + P IV Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + H V +R Sbjct: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Query: 140 DLKLENTLLDGSPAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 DLK N LLD R+ CDF K P ++VGT Y+APEVL K Sbjct: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 369 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 AD +S G L+ +L G PF + K+ + L + +PD SPE R L+ Sbjct: 370 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLE 426 Query: 256 RIFVADPAKRISI-----------PEIRNHEW---FLKNLPADLM--------NDNTMTT 293 + D +R+ P R+ +W FL+ P L+ D Sbjct: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIG 486 Query: 294 QFDESDQPG 302 FDE D G Sbjct: 487 SFDEEDTKG 495 >3NIZ-A nrPDB Length = 311 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 134/301 (44%), Gaps = 35/301 (11%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVK 63 SG +L ++Y+ ++ +G G +GV +D Q +VA+K I E I Sbjct: 9 SGRENLYFQGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAI 67 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFF 121 REI + L HPNIV +VI + L +V E+ +++ N + + + + Sbjct: 68 REISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEKD--LKKVLDENKTGLQDSQIKIYL 125 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTP 180 QL+ GV++CH ++ HRDLK +N L++ A LK+ DFG +++ + + + V T Sbjct: 126 YQLLRGVAHCHQHRILHRDLKPQNLLINSDGA--LKLADFGLARAFGIPVRSYTHEVVTL 183 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF----EDPEEPKNFR--------- 227 Y AP+VL+ + D+WS G M+ G F +D + PK F Sbjct: 184 WYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPRE 243 Query: 228 --------KTIHRILNVQYAIPDYVHISPECRH---LISRIFVADPAKRISIPEIRNHEW 276 R V P I C+ L+S + DP KRIS + NH + Sbjct: 244 WPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPY 303 Query: 277 F 277 F Sbjct: 304 F 304 >6CKI-A nrPDB Length = 316 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 90/305 (29%), Positives = 134/305 (43%), Gaps = 36/305 (11%) Query: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGE-KIDENVKREI-INHRSLRHP 75 D Y+L +D+ G G + + +++ AVK IE+ I V RE+ + ++ H Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHR 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N++ E +V E GG + I F+E EA Q + S + + H Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 136 VCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHS--QPKST------VGTPAYIAPE 186 + HRDLK EN L + + +KICDFG L+ P ST G+ Y+APE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 187 VL--LKKE---YDGKVADVWSCGVTLYVMLVGAYPF-----------EDPEEPKNFRKTI 230 V+ +E YD K D+WS GV LY++L G PF P Sbjct: 192 VVEAFSEEASIYD-KRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 231 HRILNVQYAIP--DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 I +Y P D+ HIS + LIS++ V D +R+S ++ H W P + Sbjct: 251 ESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAP-----E 305 Query: 289 NTMTT 293 NT+ T Sbjct: 306 NTLPT 310 >4IDT-A nrPDB Length = 356 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 75/257 (29%), Positives = 116/257 (45%), Gaps = 27/257 (10%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +G G+FG M DKQ+ AVK + +++ E++ L P IV + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKV----RLEVFRAEELMACAGLTSPRIVPLYGAVRE 137 Query: 87 PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENT 146 + I ME GG L + + G ED A ++ Q + G+ Y H+ ++ H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNV 197 Query: 147 LL--DGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLKKEYDGKVA 198 LL DGS A +CDFG++ K + GT ++APEV+L + D KV Sbjct: 198 LLSSDGSHA---ALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKV- 253 Query: 199 DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI- 257 DVWS + ML G +P+ + FR + L + P I P C L ++ Sbjct: 254 DVWSSCCMMLHMLNGCHPWT-----QFFRGPL--CLKIASEPPPVREIPPSCAPLTAQAI 306 Query: 258 ---FVADPAKRISIPEI 271 +P R+S E+ Sbjct: 307 QEGLRKEPIHRVSAAEL 323 >5L2Q-C nrPDB Length = 320 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 57/162 (35%), Positives = 84/162 (51%), Gaps = 6/162 (3%) Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 170 R SE E F ++ V H + HRDLKL N +L+ R+ I +F K V Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLGKHLVSE 207 Query: 171 SQP-KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT 229 K G+PAYI+P+VL + Y GK +D+W+ GV L+ ML G +PF D + FRK Sbjct: 208 GDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRK- 266 Query: 230 IHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 I +Y IP+ +S LI ++ V DP +R++ ++ Sbjct: 267 ---IKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADV 305 >3C51-A nrPDB Length = 543 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 79/267 (29%), Positives = 120/267 (44%), Gaps = 23/267 (8%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN------VKREIINHRSLRHPNIVRF 80 +G G FG + K + +L A K + + V+++I+ R IV Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF--IVSL 250 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYCHAMQV 136 T T L +VM +GG++ I N F E A F+ Q++SG+ + H + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYS-KSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 +RDLK EN LLD ++I D G + + ++ K GTP ++APE+LL +EYD Sbjct: 311 IYRDLKPENVLLDDD--GNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDF 368 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 V D ++ GVTLY M+ PF E ++ R+L PD SP + Sbjct: 369 SV-DYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD--KFSPASKDFCE 425 Query: 256 RIFVADPAKRI-----SIPEIRNHEWF 277 + DP KR+ S +R H F Sbjct: 426 ALLQKDPEKRLGFRDGSCDGLRTHPLF 452 >4GS6-A nrPDB Length = 315 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 85/266 (31%), Positives = 129/266 (48%), Gaps = 24/266 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-- 72 M D E+ + +G G FGV + + K + VA+K IE + K I+ R L Sbjct: 5 MIDYKEIEVEEVVGRGAFGV--VCKAKWRAKDVAIKQIES----ESERKAFIVELRQLSR 58 Query: 73 -RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA---GRFSEDEARFFFQQLISGV 128 HPNIV+ L P + +VMEYA GG L+ + A ++ A + Q GV Sbjct: 59 VNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 129 SYCHAMQ---VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 185 +Y H+MQ + HRDLK N LL LKICDFG + + + + G+ A++AP Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAG-GTVLKICDFG--TACDIQTHMTNNKGSAAWMAP 173 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 EV Y K DV+S G+ L+ ++ PF++ P FR I ++ P + Sbjct: 174 EVFEGSNYSEK-CDVFSWGIILWEVITRRKPFDEIGGPA-FR--IMWAVHNGTRPPLIKN 229 Query: 246 ISPECRHLISRIFVADPAKRISIPEI 271 + L++R + DP++R S+ EI Sbjct: 230 LPKPIESLMTRCWSKDPSQRPSMEEI 255 >3COM-A nrPDB Length = 314 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 103/201 (51%), Gaps = 6/201 (2%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +++++ +G G++G K++ ++VA+K + + E +K EI + P++V++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK-EISIMQQCDSPHVVKY 89 Query: 81 KEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 T L IVMEY G + + I +EDE Q + G+ Y H M+ HR Sbjct: 90 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHR 149 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLKKEYDGKVA 198 D+K N LL+ K+ DFG + ++TV GTP ++APEV+ + Y+ VA Sbjct: 150 DIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 206 Query: 199 DVWSCGVTLYVMLVGAYPFED 219 D+WS G+T M G P+ D Sbjct: 207 DIWSLGITAIEMAEGKPPYAD 227 >1V0B-A nrPDB Length = 288 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 134/293 (45%), Gaps = 38/293 (12%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK----REIINHRSLRH 74 ++Y ++ IG G +GV ++ E A+K I R EK DE + REI + L+H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKI-RLEKEDEGIPSTTIREISILKELKH 59 Query: 75 PNIVRFKEVILTPTHLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 NIV+ +VI T L +V E+ +L + +C G A+ F QL++G++YCH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLD-VCEGG-LESVTAKSFLLQLLNGIAYCH 117 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKK 191 +V HRDLK +N L++ LKI DFG +++ + + V T Y AP+VL+ Sbjct: 118 DRRVLHRDLKPQNLLINRE--GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI----------- 240 + D+WS G M+ GA F E + I RIL + Sbjct: 176 KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMR-IFRILGTPNSKNWPNVTELPKY 234 Query: 241 -PDYVHISP------------ECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 P++ P L+S++ DP +RI+ + H +F +N Sbjct: 235 DPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >5VO2-A nrPDB Length = 300 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 71/195 (36%), Positives = 100/195 (51%), Gaps = 15/195 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPNIVRFKEVIL 85 +GSG G L R E VAVK + ++K I H R L+HPNI+ FK V Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVR-------DLKETDIKHLRKLKHPNIITFKGVCT 70 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS-GVSYCHAMQVCHRDLKLE 144 I+ME+ + G+L+E + AGR + I+ G++Y H ++ HRDLK Sbjct: 71 QAPCYCILMEFCAQGQLYE-VLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 129 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCG 204 N L+ +KI DFG SK S S GT A++APEV+ + KV D+WS G Sbjct: 130 NMLITYDDV--VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV-DIWSFG 186 Query: 205 VTLYVMLVGAYPFED 219 V L+ +L G P++D Sbjct: 187 VVLWELLTGEIPYKD 201 >4G3E-A nrPDB Length = 352 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 12/197 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +G G+FG M+DKQ+ AVK + +++ E++ L P IV + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKV----RLEVFRVEELVACAGLSSPRIVPLYGAVRE 137 Query: 87 PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENT 146 + I ME GG L + I G ED A ++ Q + G+ Y H ++ H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNV 197 Query: 147 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLKKEYDGKVADV 200 LL S R +CDFG++ KS + GT ++APEV++ K D KV D+ Sbjct: 198 LLS-SDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV-DI 255 Query: 201 WSCGVTLYVMLVGAYPF 217 WS + ML G +P+ Sbjct: 256 WSSCCMMLHMLNGCHPW 272 >5KKR-C nrPDB Length = 395 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 66/208 (31%), Positives = 106/208 (50%), Gaps = 11/208 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 D +E + ++G+GN GV + K S ++A K I +I ++ +II + H Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 125 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P IV F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 185 Query: 135 -QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 ++ HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 186 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 242 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPE 221 + +D+WS G++L M VG YP P+ Sbjct: 243 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 269 >4UY9-A nrPDB Length = 323 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 105/206 (50%), Gaps = 21/206 (10%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKID-----ENVKREIINHRSLRHPNIVRFK 81 IG G FG ++ R + VAVK D ENV++E L+HPNI+ + Sbjct: 17 IGIGGFG--KVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH---AMQVCH 138 V L +L +VME+A GG L R+ + R D + Q+ G++Y H + + H Sbjct: 75 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 133 Query: 139 RDLKLENTLL-----DGSPAPR-LKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKK 191 RDLK N L+ +G + + LKI DFG ++ H K S GT A++APEV+ Sbjct: 134 RDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGTYAWMAPEVIRAS 191 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPF 217 + K +DVWS GV L+ +L G PF Sbjct: 192 MFS-KGSDVWSYGVLLWELLTGEVPF 216 >3QA8-A nrPDB Length = 676 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 77/239 (32%), Positives = 109/239 (45%), Gaps = 23/239 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPNI 77 +E+ + +G+G FG + + E VA+K R E +N +R EI + L HPN+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC-RQELSPKNRERWCLEIQIMKKLNHPNV 74 Query: 78 VRFKEV-----ILTPTHLAIV-MEYASGGEL------FERICNAGRFSEDEARFFFQQLI 125 V +EV L P L ++ MEY GG+L FE C E R + Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCG---LKEGPIRTLLSDIS 131 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRL--KICDFGYSKSSVLHSQPKSTVGTPAYI 183 S + Y H ++ HRDLK EN +L P RL KI D GY+K VGT Y+ Sbjct: 132 SALRYLHENRIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGELCTEFVGTLQYL 190 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 APE+L +K+Y V D WS G + + G PF +P + + N + D Sbjct: 191 APELLEQKKYTVTV-DYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYD 248 >3EQC-A nrPDB Length = 360 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/208 (31%), Positives = 106/208 (50%), Gaps = 11/208 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 D +E + ++G+GN GV + K S ++A K I +I ++ +II + H Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 90 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P IV F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 135 -QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 ++ HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 151 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 207 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPE 221 + +D+WS G++L M VG YP P+ Sbjct: 208 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 234 >4AN9-A nrPDB Length = 301 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 130/268 (48%), Gaps = 17/268 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 D +E + ++G+GN GV + K S ++A K I +I ++ +II + H Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 66 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH-A 133 P IV F + ++I ME+ GG L + + AGR E +I G++Y Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 ++ HRD+K N L++ +K+CDFG S ++ VGT +Y++PE L Y Sbjct: 127 HKIMHRDVKPSNILVNSR--GEIKLCDFGVS-GQLIDEMANEFVGTRSYMSPERLQGTHY 183 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN-VQYAIPDYVHISPECRH 252 + +D+WS G++L M VG Y P P + + I+N +P V S E + Sbjct: 184 SVQ-SDIWSMGLSLVEMAVGRY----PRPPMAIFELLDYIVNEPPPKLPSAV-FSLEFQD 237 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKN 280 +++ + +PA+R + ++ H + ++ Sbjct: 238 FVNKCLIKNPAERADLKQLMVHAFIKRS 265 >4FR4-A nrPDB Length = 384 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 116/255 (45%), Gaps = 11/255 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRH 74 D +E+++ IG G+FG +++ + ++ A+KY+ + + ++ N R + + L H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V + +V++ GG+L + F E+ + F +L+ + Y Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 134 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 ++ HRD+K +N LLD + I DF + +Q + GT Y+APE+ ++ Sbjct: 135 RIIHRDMKPDNILLDEH--GHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGA 192 Query: 195 GK--VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 G D WS GVT Y +L G P+ + ++ +H P S E Sbjct: 193 GYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSS-KEIVHTFETTVVTYPS--AWSQEMVS 249 Query: 253 LISRIFVADPAKRIS 267 L+ ++ +P +R S Sbjct: 250 LLKKLLEPNPDQRFS 264 >1S9I-A nrPDB Length = 354 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 107/208 (51%), Gaps = 11/208 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH---- 74 D +E + ++G+GN GV ++ + S ++A K I +I ++ +II + H Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL--EIKPAIRNQIIRELQVLHECNS 73 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P IV F + ++I ME+ GG L + + A R E+ ++ G++Y Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 135 -QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Q+ HRD+K N L++ +K+CDFG S ++ S S VGT +Y+APE L Y Sbjct: 134 HQIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMAPERLQGTHY 190 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPE 221 + +D+WS G++L + VG YP P+ Sbjct: 191 SVQ-SDIWSMGLSLVELAVGRYPIPPPD 217 >3DTC-A nrPDB Length = 271 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/206 (34%), Positives = 105/206 (50%), Gaps = 21/206 (10%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYI-----ERGEKIDENVKREIINHRSLRHPNIVRFK 81 IG G FG ++ R + VAVK E + ENV++E L+HPNI+ + Sbjct: 15 IGIGGFG--KVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH---AMQVCH 138 V L +L +VME+A GG L R+ + R D + Q+ G++Y H + + H Sbjct: 73 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 131 Query: 139 RDLKLENTLL-----DGSPAPR-LKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKK 191 RDLK N L+ +G + + LKI DFG ++ H K S G A++APEV+ Sbjct: 132 RDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGAYAWMAPEVIRAS 189 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPF 217 + K +DVWS GV L+ +L G PF Sbjct: 190 MFS-KGSDVWSYGVLLWELLTGEVPF 214 >4QMW-A nrPDB Length = 310 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 140/293 (47%), Gaps = 36/293 (12%) Query: 4 PAVSGPMDLPIMHD--SDRYEL---VKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGE 56 P SG LP M + +D EL ++ IG G+FG D ++ ++VA+K I+ E Sbjct: 12 PVQSG---LPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE 68 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE 116 E++++EI P + ++ L T L I+MEY GG + + G E + Sbjct: 69 DEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALD-LLEPGPLDETQ 127 Query: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-- 174 ++++ G+ Y H+ + HRD+K N LL S +K+ DFG + + +Q K Sbjct: 128 IATILREILKGLDYLHSEKKIHRDIKAANVLL--SEHGEVKLADFGVA-GQLTDTQIKRN 184 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--PEE-----PKNFR 227 + VGTP ++APEV+ + YD K AD+WS G+T + G P + P + PKN Sbjct: 185 TFVGTPFWMAPEVIKQSAYDSK-ADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNP 243 Query: 228 KTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 T L Y+ P + + +P+ R + E+ H++ L+N Sbjct: 244 PT----LEGNYSKP--------LKEFVEACLNKEPSFRPTAKELLKHKFILRN 284 >4KIK-B nrPDB Length = 677 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 107/228 (46%), Gaps = 21/228 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPNI 77 +E+ + +G+G FG ++++ E +A+K R E N +R EI R L HPN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHPNV 79 Query: 78 VRFKEV-----ILTPTHLAIV-MEYASGGEL------FERICNAGRFSEDEARFFFQQLI 125 V ++V L P L ++ MEY GG+L FE C E + Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCG---LREGAILTLLSDIA 136 Query: 126 SGVSYCHAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 S + Y H ++ HRDLK EN +L G KI D GY+K S S VGT Y+A Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 PE+L +++Y V D WS G + + G PF +P + + + Sbjct: 197 PELLEQQKYTVTV-DYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQ 243 >5DBX-A nrPDB Length = 328 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 87/290 (30%), Positives = 131/290 (45%), Gaps = 30/290 (10%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHR 70 PI D+ YEL + IGSG V + K E VA+K I E+ + + + +EI Sbjct: 7 PICRDA--YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMS 64 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELF---ERICNAGR-----FSEDEARFFFQ 122 HPN+V + + L +VM+ SGG + + I N G E + Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSK------SSVLHSQPK 174 +++ G+ Y H HRDLK N LL DGS ++I DFG S + K Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGS----VQIADFGVSAFLATGGDVTRNKVRK 180 Query: 175 STVGTPAYIAPEVLLK-KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR- 232 VGTP ++APEV+ + + YD K AD+WS G+T + GA P+ K T+ Sbjct: 181 DFVGTPCWMAPEVMEQVRGYDFK-ADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND 239 Query: 233 ILNVQYAIPDYVHI---SPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 ++ + D + R L+S DP+KR + E+ ++F K Sbjct: 240 PPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >4AGU-A nrPDB Length = 311 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 129/291 (44%), Gaps = 37/291 (12%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK---IDENVKREIINHRSLRHP 75 ++YE + IG G++GV R++ + ++VA+K E I + REI + L+HP Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N+V EV L +V EY L E E + Q + V++CH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHN 122 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK----STVGTPAYIAPEVLLKK 191 HRD+K EN L+ +K+CDFG+++ L + P V T Y +PE+L+ Sbjct: 123 CIHRDVKPENILITKHSV--IKLCDFGFAR---LLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 192 EYDGKVADVWSCGVTLYVMLVGA--YPFE-DPEEPKNFRKTIHRIL--------NVQY-- 238 G DVW+ G +L G +P + D ++ RKT+ ++ QY Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 239 --AIPD----------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 IPD + +IS L+ DP +R++ ++ +H +F Sbjct: 238 GVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >4NST-A nrPDB Length = 351 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 65/204 (31%), Positives = 97/204 (47%), Gaps = 17/204 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 D+++++ IG G +G +DK + ELVA+K + E REI R L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 76 NIVRFKEVILTPT----------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 ++V KE++ +V EY + FSED + F +QL+ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKST-VGTPAYI 183 G+ YCH HRD+K N LL+ S ++K+ DFG ++ + S+P + V T Y Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNS--GQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 184 APEVLLKKEYDGKVADVWSCGVTL 207 PE+LL +E DVWSCG L Sbjct: 191 PPELLLGEERYTPAIDVWSCGCIL 214 >4BBM-A nrPDB Length = 331 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 104/203 (51%), Gaps = 14/203 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVK-YIERGEKIDENVK----REIINHRSLR 73 ++YE + +G G++G+ R+K + +VA+K ++E + D+ VK REI + LR Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLR 82 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYC 131 H N+V EV +V E+ L E N + + F Q+I+G+ +C Sbjct: 83 HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLF--QIINGIGFC 140 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLK 190 H+ + HRD+K EN L+ S +K+CDFG++++ + V T Y APE+L+ Sbjct: 141 HSHNIIHRDIKPENILVSQSGV--VKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 191 KEYDGKVADVWSCGVTLYVMLVG 213 GK DVW+ G + M +G Sbjct: 199 DVKYGKAVDVWAIGCLVTEMFMG 221 >4LG4-A nrPDB Length = 299 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 128/282 (45%), Gaps = 33/282 (11%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +++++ +G G++G K+S ++VA+K + + E +K EI + P +V++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK-EISIMQQCDSPYVVKY 71 Query: 81 KEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 T L IVMEY G + + I EDE + + G+ Y H M+ HR Sbjct: 72 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 131 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLKKEYDGKVA 198 ++K N LL+ K+ DFG + ++TV GTP ++APEV+ + Y+ VA Sbjct: 132 NIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 188 Query: 199 DVWSCGVTLYVMLVGAYPFED-----------PEEPKNFRKTIHRILNVQYAIPDYVHIS 247 D+WS G+T M G P+ D P FRK P+ S Sbjct: 189 DIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK------------PEL--WS 234 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNL-PADLMND 288 + + + V +P +R + ++ H F+KN P ++ D Sbjct: 235 DDFTDFVKKCLVKNPEQRATATQLLQHP-FIKNAKPVSILRD 275 >6AO5-A nrPDB Length = 362 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 128/282 (45%), Gaps = 33/282 (11%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +++++ +G G++G K+S ++VA+K + + E +K EI + P +V++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK-EISIMQQCDSPYVVKY 70 Query: 81 KEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 T L IVMEY G + + I EDE + + G+ Y H M+ HR Sbjct: 71 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 130 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLKKEYDGKVA 198 ++K N LL+ K+ DFG + ++TV GTP ++APEV+ + Y+ VA Sbjct: 131 NIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 187 Query: 199 DVWSCGVTLYVMLVGAYPFED-----------PEEPKNFRKTIHRILNVQYAIPDYVHIS 247 D+WS G+T M G P+ D P FRK P+ S Sbjct: 188 DIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK------------PEL--WS 233 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNL-PADLMND 288 + + + V +P +R + ++ H F+KN P ++ D Sbjct: 234 DDFTDFVKKCLVKNPEQRATATQLLQHP-FIKNAKPVSILRD 274 >5X5O-A nrPDB Length = 310 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 83/259 (32%), Positives = 125/259 (48%), Gaps = 22/259 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 D + ++ G G+FG + ++ VAVK + + EK + EI++ L H NI+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK-----EAEILS--VLSHRNII 67 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCHA-- 133 +F VIL P + IV EYAS G L++ I N+ R E D + + G+ Y H Sbjct: 68 QFYGVILEPPNYGIVTEYASLGSLYDYI-NSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 134 -MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++V HRDLK N ++ LKICDFG S+ H+ S VGT ++APEV+ Sbjct: 127 PVKVIHRDLKSRNVVIAADGV--LKICDFGASRFHN-HTTHMSLVGTFPWMAPEVIQSLP 183 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 + D +S GV L+ ML PF+ E + + + N + IP S Sbjct: 184 VS-ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK--NERLTIPSSCPRS--FAE 238 Query: 253 LISRIFVADPAKRISIPEI 271 L+ + + AD KR S +I Sbjct: 239 LLHQCWEADAKKRPSFKQI 257 >4AW2-A nrPDB Length = 437 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 92/345 (26%), Positives = 156/345 (45%), Gaps = 49/345 (14%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 +H D +E++K IG G FG +++ K ++++ A+K + + E + + E R R Sbjct: 71 LHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLK---RAETACFREERD 126 Query: 75 PNIVRFKEVILTPTHLA--------IVMEYASGGELFERICN-AGRFSEDEARFFFQQLI 125 +V +T H A +VM+Y GG+L + R E+ ARF+ +++ Sbjct: 127 V-LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMV 185 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYI 183 + H + HRD+K +N L+D + RL DFG + +S+ VGTP YI Sbjct: 186 IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLA--DFGSCLKLMEDGTVQSSVAVGTPDYI 243 Query: 184 APEVLLKKEYD----GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN--VQ 237 +PE+L E G D WS GV +Y ML G PF ++ +T +I+N + Sbjct: 244 SPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF----YAESLVETYGKIMNHKER 299 Query: 238 YAIPDYV-HISPECRHLISRIFVADPAK--RISIPEIRNHEWF-------LKNLPADLM- 286 + P V +S + LI R+ + + + I + + H +F ++N A + Sbjct: 300 FQFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 359 Query: 287 --NDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYL 329 + T T+ FD D ++ +E PP T H+L Sbjct: 360 EVSSPTDTSNFDVDDDCLKN--------SETMPPPTHTAFSGHHL 396 >2XIK-A nrPDB Length = 294 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/197 (33%), Positives = 100/197 (50%), Gaps = 9/197 (4%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+FG D + E+VA+K I+ E E++++EI P I R+ Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 86 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L T L I+MEY GG + + G E ++++ G+ Y H+ + HRD+K Sbjct: 87 LKSTKLWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAA 145 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLLKKEYDGKVADVWS 202 N LL S +K+ DFG + + +Q K + VGTP ++APEV+ + YD K AD+WS Sbjct: 146 NVLL--SEQGDVKLADFGVA-GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK-ADIWS 201 Query: 203 CGVTLYVMLVGAYPFED 219 G+T + G P D Sbjct: 202 LGITAIELAKGEPPNSD 218 >3ZDU-A nrPDB Length = 325 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/293 (25%), Positives = 128/293 (43%), Gaps = 36/293 (12%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVK-YIERGEK-IDENVKREIINHRSLRHPN 76 + YE + +G G++G + K + ++VA+K + ER E+ +++ REI + H N Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 62 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V EV + +V E+ L E R + Q++ + Y H+ + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST----VGTPAYIAPEVLLKKE 192 HRD+K EN L+ S +L CDFG++++ + P V T Y APE++LK Sbjct: 123 IHRDIKPENILVSQSGITKL--CDFGFARTL---AAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ--------------- 237 GK D+W+ G + M G + K + ++ N+ Sbjct: 178 SYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAG 237 Query: 238 YAIPDYVHIS------PECRHLISRIFVA----DPAKRISIPEIRNHEWFLKN 280 +P H P+ L++ I A DPA RIS ++ +HE+F ++ Sbjct: 238 VVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >4FZF-B nrPDB Length = 283 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 126/264 (47%), Gaps = 26/264 (9%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+FG D ++ ++VA+K I+ E E++++EI + ++ Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 75 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L + L I+MEY GG + + AG F E + ++++ G+ Y H+ + HRD+K Sbjct: 76 LKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAA 134 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLLKKEYDGKVADVWS 202 N LL S +K+ FG + + +Q K + VGTP ++APEV+ + YD K AD+WS Sbjct: 135 NVLL--SEQGDVKLAAFGVA-GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK-ADIWS 190 Query: 203 CGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL------NVQYAIPDYVHISPECRHLISR 256 G+T + G EP N R+L N + D+ + + I Sbjct: 191 LGITAIELAKG--------EPPNSDMHPMRVLFLIPKNNPPTLVGDF---TKSFKEFIDA 239 Query: 257 IFVADPAKRISIPEIRNHEWFLKN 280 DP+ R + E+ H++ +KN Sbjct: 240 CLNKDPSFRPTAKELLKHKFIVKN 263 >4KRC-A nrPDB Length = 317 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 111/219 (50%), Gaps = 14/219 (6%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSL 72 M S +++ ++ +G+G + +K + VA+K ++ E REI + L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFE-----RICNAGRFSE-DEARFFFQQLIS 126 +H NIVR +VI T L +V E+ +L + + N R E + ++F QL+ Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAP 185 G+++CH ++ HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP Sbjct: 120 GLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFEDPEE 222 +VL+ D+WSCG L M+ G +P + EE Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 >2VD5-A nrPDB Length = 412 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/289 (25%), Positives = 126/289 (43%), Gaps = 23/289 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVK------YIERGEKIDENVKREIINHRSL 72 D +E++K IG G F +++ KQ+ ++ A+K ++RGE +R+++ + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYC 131 R I + +L +VMEY GG+L + G R + ARF+ +++ + Sbjct: 121 RW--ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 178 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS--TVGTPAYIAPEVLL 189 H + HRD+K +N LLD +++ DFG +S VGTP Y++PE+L Sbjct: 179 HRLGYVHRDIKPDNILLD--RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 236 Query: 190 KKEYDGKV------ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 D W+ GV Y M G PF + + K +H ++ + D Sbjct: 237 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 296 Query: 244 VHISPECRHLISRIFVADPAK--RISIPEIRNHEWFLKNLPADLMNDNT 290 + E R I R+ + R + R H +F L D + D+ Sbjct: 297 -GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFF-GLDWDGLRDSV 343 >6DTL-A nrPDB Length = 364 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 63/185 (34%), Positives = 91/185 (49%), Gaps = 9/185 (4%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERG--EKID-ENVKREIINHRSLRHPNIVRFKEV 83 IG G +G+ + ++NE VA+K I KID + REI R + H NIV +++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 84 ILTPTHLAIVMEYAS----GGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 I P A Y + +L + I + SE+ ++F Q++ G+ Y H+ V HR Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 157 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 DLK N LL+ + LKICDFG ++ + V T Y APE+LL D Sbjct: 158 DLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 215 Query: 200 VWSCG 204 VWS G Sbjct: 216 VWSVG 220 >1UA2-A nrPDB Length = 346 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 134/300 (44%), Gaps = 37/300 (12%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK------IDENVK 63 M L + + RYE + +G G F RDK +N++VA+K I+ G + I+ Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFF 121 REI + L HPNI+ + +++++V ++ E I N+ + + + Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTP 180 + G+ Y H + HRDLK N LLD + LK+ DFG +KS ++ + V T Sbjct: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTR 176 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF----EDPEEPKNFRKTIHRILNV 236 Y APE+L G D+W+ G L +L+ PF D ++ +T+ Sbjct: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEE 235 Query: 237 QY----AIPDYV-----------HI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 Q+ ++PDYV HI + LI +F+ +P RI+ + ++F Sbjct: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 >5EFQ-A nrPDB Length = 347 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 101/219 (46%), Gaps = 17/219 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 D+++++ IG G +G RDK + E+VA+K + E REI R L H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 76 NIVRFKEVILTPT----------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 +I+ KE++ +V EY + F+E+ + F +QL+ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKST-VGTPAYI 183 G+ YCH HRD+K N LL+ ++K+ DFG ++ S S+P + V T Y Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNR--GQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE 222 PE+LL +E DVWSCG L + F+ +E Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE 227 >6HXF-B nrPDB Length = 302 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 62/200 (31%), Positives = 107/200 (53%), Gaps = 15/200 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVR 79 +E+V ++G G FG ++K++ L A K IE + E+ E+ EI + HP IV+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK 80 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQVCH 138 L I++E+ GG + + R +E + + +Q++ +++ H+ ++ H Sbjct: 81 LLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 139 RDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE--- 192 RDLK N L L+G +++ DFG S ++ Q + S +GTP ++APEV++ + Sbjct: 141 RDLKAGNVLMTLEGD----IRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 193 --YDGKVADVWSCGVTLYVM 210 YD K AD+WS G+TL M Sbjct: 197 TPYDYK-ADIWSLGITLIEM 215 >5AIR-A nrPDB Length = 430 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 103/221 (46%), Gaps = 21/221 (9%) Query: 6 VSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKRE 65 V+ P P Y K IG+G+FGV + S ELVA+K + + ++ RE Sbjct: 51 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RE 107 Query: 66 IINHRSLRHPNIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDE--- 116 + R L H NIVR + + +L +V++Y E R+ A +S + Sbjct: 108 LQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTL 163 Query: 117 ----ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 172 + + QL ++Y H+ +CHRD+K +N LLD A LK+CDFG +K V Sbjct: 164 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEP 222 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 S + + Y APE++ DVWS G L +L+G Sbjct: 223 NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLG 263 >4U41-A nrPDB Length = 332 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/235 (30%), Positives = 120/235 (51%), Gaps = 20/235 (8%) Query: 2 DRPAVS-GPMDLPIMHD-SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 D PA S +DL + D + +ELV+ +G+G +G R ++ +L A+K ++ E + Sbjct: 5 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 64 Query: 60 ENVKREI-INHRSLRHPNIVRFKEVILT---PTH---LAIVMEYASGGELFERICN--AG 110 E +K EI + + H NI + + P H L +VME+ G + + + N Sbjct: 65 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 124 Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 170 ED + ++++ G+++ H V HRD+K +N LL + +K+ DFG S Sbjct: 125 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLL--TENAEVKLVDFGVSAQLDRT 182 Query: 171 SQPKST-VGTPAYIAPEVLLKKE-----YDGKVADVWSCGVTLYVMLVGAYPFED 219 ++T +GTP ++APEV+ E YD + +D+WSCG+T M GA P D Sbjct: 183 VGRRNTFIGTPYWMAPEVIACDENPDATYDYR-SDLWSCGITAIEMAEGAPPLCD 236 >4IC8-A nrPDB Length = 442 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 105/214 (49%), Gaps = 27/214 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-----EIINHRSL 72 D YE+++ IG+G +GV R + + + VA+K I + N KR +I+ H Sbjct: 54 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--F 111 Query: 73 RHPNIVRFKEVILTPT-------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 +H NI+ K+ IL PT + +V++ +L + I ++ + + R+F QL+ Sbjct: 112 KHDNIIAIKD-ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-------STVG 178 G+ Y H+ QV HRDLK N L++ + LKI DFG ++ L + P V Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARG--LCTSPAEHQYFMTEYVA 225 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV 212 T Y APE++L + D+WS G ML Sbjct: 226 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 259 >2WQN-A nrPDB Length = 310 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 112/256 (43%), Gaps = 18/256 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPN 76 + + K IG G F VA+K ++ + +D + + I + L HPN Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYCH 132 ++++ + L IV+E A G+L I + + E +F QL S + + H Sbjct: 94 VIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMH 153 Query: 133 AMQVCHRDLKLENTLLDGSPAPR---LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 + +V HRD+K N + + + L + F SK++ H S VGTP Y++PE + Sbjct: 154 SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAH----SLVGTPYYMSPERIH 209 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 + Y+ K +D+WS G LY M PF + N +I Y H S E Sbjct: 210 ENGYNFK-SDIWSLGCLLYEMAALQSPFYG--DKMNLYSLCKKIEQCDYPPLPSDHYSEE 266 Query: 250 CRHLISRIFVADPAKR 265 R L++ DP KR Sbjct: 267 LRQLVNMCINPDPEKR 282 >4ZSG-A nrPDB Length = 347 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 105/213 (49%), Gaps = 27/213 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-----EIINHRSL 72 D YE+++ IG+G +GV R + + + VA+K I + N KR +I+ H Sbjct: 6 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--F 63 Query: 73 RHPNIVRFKEVILTPT-------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 +H NI+ K+ IL PT + +V++ +L + I ++ + + R+F QL+ Sbjct: 64 KHDNIIAIKD-ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-------KSTVG 178 G+ Y H+ QV HRDLK N L++ + LKI DFG ++ L + P V Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARG--LCTSPAEHQYFMTEYVA 177 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 T Y APE++L + D+WS G ML Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML 210 >5D7A-A nrPDB Length = 308 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 114/226 (50%), Gaps = 19/226 (8%) Query: 10 MDLPIMHD-SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-I 67 +DL + D + +ELV+ +G+G +G R ++ +L A+K ++ +E +K+EI + Sbjct: 7 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 66 Query: 68 NHRSLRHPNIVRFKEVILTPT------HLAIVMEYASGGELFERICN--AGRFSEDEARF 119 + H NI + + L +VME+ G + + I N E+ + Sbjct: 67 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY 126 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VG 178 ++++ G+S+ H +V HRD+K +N LL + +K+ DFG S ++T +G Sbjct: 127 ICREILRGLSHLHQHKVIHRDIKGQNVLL--TENAEVKLVDFGVSAQLDRTVGRRNTFIG 184 Query: 179 TPAYIAPEVLLKKE-----YDGKVADVWSCGVTLYVMLVGAYPFED 219 TP ++APEV+ E YD K +D+WS G+T M GA P D Sbjct: 185 TPYWMAPEVIACDENPDATYDFK-SDLWSLGITAIEMAEGAPPLCD 229 >2F9G-A nrPDB Length = 353 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 127/303 (41%), Gaps = 46/303 (15%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 S ++L +G G +GV K + E+VA+K IE +K REI + +H Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE----RICNAGRFSEDEARFFFQQLISGVSYC 131 NI+ I P E EL + R+ + S+D ++F Q + V Sbjct: 70 NIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKST-------VGTP 180 H V HRDLK N L++ + LK+CDFG ++ S+ +S+P V T Sbjct: 129 HGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG--AYPFED--------------PEEPK 224 Y APEV+L + DVWSCG L + + +P D P Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 225 NFR-------KTIHRILNVQYAIP---DYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 + R + + L + A P + ++P+ L+ R+ V DPAKRI+ E H Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 275 EWF 277 + Sbjct: 307 PYL 309 >3SXS-A nrPDB Length = 268 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/201 (32%), Positives = 102/201 (50%), Gaps = 10/201 (4%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 L+K++GSG FGV +L + K + VAVK I+ G ++ +E L HP +V+F Sbjct: 12 LLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 70 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF-FFQQLISGVSYCHAMQVCHRDL 141 V + IV EY S G L + + G+ E + G+++ + Q HRDL Sbjct: 71 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 130 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEYDGKVA 198 N L+D +K+ DFG ++ VL Q S+VGT + APEV +Y K + Sbjct: 131 AARNCLVDRDLC--VKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSK-S 186 Query: 199 DVWSCGVTLY-VMLVGAYPFE 218 DVW+ G+ ++ V +G P++ Sbjct: 187 DVWAFGILMWEVFSLGKMPYD 207 >5TQX-A nrPDB Length = 655 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 66/223 (29%), Positives = 103/223 (46%), Gaps = 12/223 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVK--YIERGEKIDENVKREIINHRSLRHPNIV 78 +E+ + +G+G FG L + ++ + +A+K +E K E EI + L H N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 79 RFKEV-----ILTPTHLAIVMEYASGGELFERIC---NAGRFSEDEARFFFQQLISGVSY 130 + +V IL + MEY SGG+L + + N E + + SG+ Y Sbjct: 70 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 129 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H ++ HRDLK EN +L + KI D GY+K VGT Y+APE+ Sbjct: 130 LHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFE 189 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 K Y V D WS G ++ + G PF +P + + I + Sbjct: 190 NKPYTATV-DYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK 231 >5G6V-A nrPDB Length = 324 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 103/216 (47%), Gaps = 12/216 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 +G G + + K ++ LVA+K I E E RE+ + L+H NIV ++I Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDII 69 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRF-SEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 T L +V EY +L + + + G + + F QL+ G++YCH +V HRDLK Sbjct: 70 HTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKP 128 Query: 144 ENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKEYDGKVADVWS 202 +N L++ LK+ DFG +++ + ++ + V T Y P++LL D+W Sbjct: 129 QNLLIN--ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQIDMWG 186 Query: 203 CGVTLYVMLVG--AYPFEDPEEPKNFRKTIHRILNV 236 G Y M G +P EE +F I RIL Sbjct: 187 VGCIFYEMATGRPLFPGSTVEEQLHF---IFRILGT 219 >3NYO-A nrPDB Length = 576 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 96/369 (26%), Positives = 164/369 (44%), Gaps = 42/369 (11%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKR- 64 P+ ++ R V +G G FG + + + ++ A K +E+ GE + N K+ Sbjct: 180 PVTKNTFRQYRV--LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 Query: 65 -EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFF 121 E +N R +V T L +V+ +GG+L I + G+ F E A F+ Sbjct: 238 LEKVNSRF-----VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 ++ G+ H ++ +RDLK EN LLD ++I D G + K VGT Sbjct: 293 AEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVG 350 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+APEV+ + Y D W+ G LY M+ G PF+ + K R+ + R++ +P Sbjct: 351 YMAPEVVKNERYTFS-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVK---EVP 405 Query: 242 DYV--HISPECRHLISRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 + SP+ R L S++ DPA+R+ S E++ H F K L + + Sbjct: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-KKLNFKRLGAGMLEPP 464 Query: 295 FDESDQPGQSIEEIMQIIAEATVP-----PAGTQNLNHYLTGSLDI---DDDMEEDLESD 346 F + D ++++ I +TV P + TGS+ I ++ +E + + Sbjct: 465 F-KPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQE 523 Query: 347 LDDLDIDSS 355 L+ +D S Sbjct: 524 LNVFGLDGS 532 >1CM8-A nrPDB Length = 367 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 44/293 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNI 77 Y ++ +GSG +G D ++ VA+K + R E + RE+ + +RH N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 78 VRFKEVILTP-------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 + +V TP T +VM + G ++ + ED +F Q++ G+ Y Sbjct: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 HA + HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFE--------------------------DPEEPK 224 + D+WS G + M+ G F+ +E K Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 N+ K + + +A + SP +L+ ++ V D +R++ E H +F Sbjct: 260 NYMKGLPELEKKDFA-SILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 >4PWN-A nrPDB Length = 274 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 125/264 (47%), Gaps = 21/264 (7%) Query: 26 DIGSGNFGVARLMRDKQSNELVAV-----KYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +IG G+F D ++ VA + + + E+ + K E + L+HPNIVRF Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER--QRFKEEAEMLKGLQHPNIVRF 74 Query: 81 ----KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 + + + +V E + G L + R + +Q++ G+ + H Sbjct: 75 YDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRDLK +N + G P +KI D G + S KS +GTP ++APE + +++YD Sbjct: 135 PIIHRDLKCDNIFITG-PTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE-MYEEKYD 192 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN-VQYAIPDYVHISPECRHL 253 V DV++ G+ + M YP+ E +N + R+ + V+ A D V I PE + + Sbjct: 193 ESV-DVYAFGMCMLEMATSEYPY---SECQNAAQIYRRVTSGVKPASFDKVAI-PEVKEI 247 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 I + +R SI ++ NH +F Sbjct: 248 IEGCIRQNKDERYSIKDLLNHAFF 271 >3OHT-A nrPDB Length = 389 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 79/332 (23%), Positives = 142/332 (42%), Gaps = 46/332 (13%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHP 75 +RY+ + +GSG +G D +S +AVK + R + + KR E+ + ++H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 76 NIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 N++ +V T L ++ + G +L I + ++D +F Q++ G+ Y Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 169 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVL 188 H+ + HRDLK N ++ LKI DFG ++ H+ + T V T Y APE++ Sbjct: 170 IHSADIIHRDLKPSNLAVNED--CELKILDFGLAR----HTDDEMTGYVATRWYRAPEIM 223 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------------HR 232 L + D+WS G + +L G F + ++ + H Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHE 283 Query: 233 ILNVQYAIPD---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 N ++P ++ +P L+ ++ V D KRI+ E H +F + Sbjct: 284 ARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDP 343 Query: 284 DLMNDNTMTTQFDESDQPGQ-SIEEIMQIIAE 314 D D + +D+S + Q IEE ++ E Sbjct: 344 D---DEPESEPYDQSFESRQLEIEEWKRLTYE 372 >4EWQ-A nrPDB Length = 383 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 70/295 (23%), Positives = 131/295 (44%), Gaps = 44/295 (14%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHP 75 +RY+ + +GSG +G D ++ VAVK + R + + KR E+ + ++H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 76 NIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 N++ +V L ++ + G +L I + ++D +F Q++ G+ Y Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKY 163 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVL 188 H+ + HRDLK N L + LKI DFG ++ H+ + T V T Y APE++ Sbjct: 164 IHSADIIHRDLKPSN--LAVNEDCELKILDFGLAR----HTDDEMTGYVATRWYRAPEIM 217 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVG--AYPFED------------------------PEE 222 L + + D+WS G + +L G +P D E Sbjct: 218 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 277 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +N+ +++ ++ + +A ++ +P L+ ++ V D KRI+ + H +F Sbjct: 278 ARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 331 >3ORP-A nrPDB Length = 311 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 96/214 (44%), Gaps = 15/214 (7%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----RGEKIDENVKREIINHRS 71 H SDRYEL + +G G L RD + + VAVK + R +RE N + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 72 LRHPNIVRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 L HP IV + T IVMEY G L + + G + A Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYI 183 +++ H + HRD+K N ++ + A +K+ DFG ++ S +Q + +GT Y+ Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNA--VKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 +PE D + +DV+S G LY +L G PF Sbjct: 187 SPEQARGDSVDAR-SDVYSLGCVLYEVLTGEPPF 219 >3E7O-A nrPDB Length = 360 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 123/297 (41%), Gaps = 45/297 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D VAVK + R + + KR E++ + + H N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHA 133 I+ V L + EL + +C D R + Q++ G+ + H+ Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHS 142 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK N ++ LKI DFG ++++ + V T Y APEV+L Y Sbjct: 143 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGY 200 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 V D+WS G + ++ G+ F+ + + K I ++ +Q + +YV Sbjct: 201 KENV-DIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVE 259 Query: 246 ISP----------------------------ECRHLISRIFVADPAKRISIPEIRNH 274 P + R L+S++ V DP KRIS+ E H Sbjct: 260 NRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRH 316 >4TNB-A nrPDB Length = 590 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 32/282 (11%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKR--EIINHRSLRHPNI 77 +G G FG + + + ++ A K +E+ GE + N K+ E +N + + Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF-----V 246 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAMQ 135 V T L +V+ +GG+L I N G F E+ A F+ +++ G+ H Sbjct: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHEN 306 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 +RDLK EN LLD ++I D G + + VGT Y+APEVL + Y G Sbjct: 307 TVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-G 363 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH-ISPECRHLI 254 D W G +Y M+ G PF +E + R+L + Y H S E + + Sbjct: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV---YSHKFSEEAKSIC 420 Query: 255 SRIFVADPAKRISI-----PEIRNHEWF----LKNLPADLMN 287 + D +R+ E++ H +F K L A +++ Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLD 462 >2BUJ-A nrPDB Length = 317 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 75/276 (27%), Positives = 116/276 (42%), Gaps = 30/276 (10%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINHRSLRHP 75 D+ Y ++ +G G F L+ A+K I E+ D E +RE HR HP Sbjct: 27 DNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHP 86 Query: 76 NIVRFKEVIL---TPTHLA-IVMEYASGGELF---ERICNAGRF-SEDEARFFFQQLISG 127 NI+R L H A +++ + G L+ ER+ + G F +ED+ + + G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---------- 177 + HA HRDLK N LL P L D G + +H + Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLM--DLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 178 GTPAYIAPEVLLKKEYD--GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRK--TIHRI 233 T +Y APE+ + + + DVWS G LY M+ G P++ F+K ++ Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD-----MVFQKGDSVALA 259 Query: 234 LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIP 269 + Q +IP S L++ + DP +R IP Sbjct: 260 VQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIP 295 >4MYG-A nrPDB Length = 372 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 126/289 (43%), Gaps = 49/289 (16%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNIVRFKEV 83 +GSG +G DK+S E VA+K + R E + RE++ + ++H N++ +V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 84 ILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + L +VM + ++I FSE++ ++ Q++ G+ Y H+ V Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 167 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 168 HRDLKPGNLAVNED--CELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV--------------------- 236 D+WS G + ML G F+ K++ + +IL V Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 279 Query: 237 ----QYAIPDYVHI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 Q D+ + SP+ L+ ++ D KR++ + H +F Sbjct: 280 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 328 >4F0G-A nrPDB Length = 287 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 82/274 (29%), Positives = 129/274 (47%), Gaps = 32/274 (11%) Query: 12 LPIMHDSDRYELVKDIGSGNFGV---ARLMRDKQSNELVAVKYIERG---------EKID 59 LP + D++ E K IG G FG+ RL++DK +VA+K + G EK Sbjct: 13 LPTLADNE-IEYEKQIGKGGFGLVHKGRLVKDKS---VVAIKSLILGDSEGETEMIEKFQ 68 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 E +RE+ +L HPNIV+ ++ P + VME+ G+L+ R+ + + + Sbjct: 69 E-FQREVFIMSNLNHPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKAHPIKWSVKL 125 Query: 120 FFQQLIS-GVSYCHAMQ--VCHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQP 173 I+ G+ Y + HRDL+ N LD + K+ DFG S+ SV HS Sbjct: 126 RLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSV-HSV- 183 Query: 174 KSTVGTPAYIAPEVLLKKE--YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH 231 +G ++APE + +E Y K AD +S + LY +L G PF++ K + Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEK-ADTYSFAMILYTILTGEGPFDEYSYGKIKFINMI 242 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 R ++ IP+ P R++I + DP KR Sbjct: 243 REEGLRPTIPE--DCPPRLRNVIELCWSGDPKKR 274 >5Z33-A nrPDB Length = 425 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 90/406 (22%), Positives = 169/406 (41%), Gaps = 81/406 (19%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----- 73 +RY + K++G G +G+ + Q++E VA+K K+ ++I+ R+LR Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIK------KVTNVFSKKILAKRALREIKLL 84 Query: 74 -----HPNIVRFKEV-ILTPTHLAIVMEYASGGEL-FERICNAGR-FSEDEARFFFQQLI 125 H NI ++ I P + Y E I +G+ ++ + F Q++ Sbjct: 85 QHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQIL 144 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-----VGTP 180 G+ Y H+ V HRDLK N L++ LKICDFG ++ + + + V T Sbjct: 145 CGLKYIHSANVLHRDLKPGNLLVNADC--ELKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Y APE++L + K DVWS G L L+G PF + +++ +++IL++ Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCIL-AELLGGRPF---FKGRDYVDQLNQILHI-LGT 257 Query: 241 PD------------------------------YVHISPECRHLISRIFVADPAKRISIPE 270 P+ + + +P+ L+ R+ DP+ RIS+ + Sbjct: 258 PNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQ 317 Query: 271 IRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEA---------TVPPAG 321 H + ++ D ++ T F+ + + + E+ ++I + T P AG Sbjct: 318 ALEHPYL--HIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEVYRFRQLVRTAPGAG 375 Query: 322 TQNLNH---------YLTGSLDIDDDMEEDLESDLDDLDIDSSGEI 358 H G +D ++ ++DL+ + +G + Sbjct: 376 GHGAPHAPQVPIPAGAGQGQWKAEDPRPQEYVGQMNDLEAELAGGL 421 >3E3P-A nrPDB Length = 360 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 97/210 (46%), Gaps = 19/210 (9%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 DR+++ + G G FG +L ++K + VA+K + + + + + + L HPNIV Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 79 RFKEVILT-------PTHLAIVMEYASGGELFERICNAGRFSEDEA------RFFFQQLI 125 + + T +L +VMEY + R C + A + F QLI Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCR-NYYRRQVAPPPILIKVFLFQLI 139 Query: 126 SGVSYCH--AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 + H ++ VCHRD+K N L++ + LK+CDFG +K + + + Y Sbjct: 140 RSIGCLHLPSVNVCHRDIKPHNVLVNEADG-TLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 APE++ ++ D+WS G M++G Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLG 228 >4QNY-A nrPDB Length = 354 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 95/341 (27%), Positives = 156/341 (45%), Gaps = 53/341 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQS-NELVAVKYIERGEKIDE-----NVKREIINHRSL 72 DRY L + IG+G++GV RD +S N LVA+K + + E +E + REI Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNK-EIFEEVILAKRILREIKLLAHF 78 Query: 73 RHPNIVRFKEVILTPT------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 126 NI+ + ILTP H IVM+ +L + + + +E +FF Q + Sbjct: 79 NDDNIIGLRN-ILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAP 185 + H+ V HRD+ N L++ + LKICDFG +K + + V Y AP Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCD--LKICDFGLAKEENDQGEYMTDYVTMRWYRAP 194 Query: 186 EVLLK-KEYDGKVADVWSCGVTLYVMLVGAYP-FEDPEEPKNFRKTI------------- 230 E++++ K+Y ++ DVW G L +L G+ P F+ + K + Sbjct: 195 ELVMEDKDYSAQI-DVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEEDINS 252 Query: 231 ------HRILNVQYAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + L + P Y SPE L+ + V +P +RI++ + H FL Sbjct: 253 VGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHP-FL 311 Query: 279 KNLPADLMNDNTMTT--QFDESDQPGQSIEEIMQIIAEATV 317 + L D +DN +FDE++Q ++I ++ + I E +V Sbjct: 312 EQLHDD-ADDNLSYALFRFDENEQ--KTIVDVKRAIYEESV 349 >6DBM-A nrPDB Length = 318 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/240 (32%), Positives = 116/240 (48%), Gaps = 27/240 (11%) Query: 7 SGPMDLPIMHDSDRY-ELVKDIGSGNFGVARLM----RDKQSNELVAVKYI--ERGEKID 59 GP D + H RY + ++D+G G+FG L + + E+VAVK + + G + Sbjct: 20 QGPGDPTVFHK--RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR 77 Query: 60 ENVKREIINHRSLRHPNIVRFKEVI--LTPTHLAIVMEYASGGELFERICNAGRFSEDEA 117 K+EI R+L H +I+++K L +VMEY G L + + R S A Sbjct: 78 SGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL---PRHSIGLA 134 Query: 118 RF--FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQ 172 + F QQ+ G++Y H+ HRDL N LLD +KI DFG +K+ + + Sbjct: 135 QLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYR 192 Query: 173 PKSTVGTPA-YIAPEVLLKKEYDGKVA-DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 + +P + APE L KEY A DVWS GVTLY +L + P P F + I Sbjct: 193 VREDGDSPVFWYAPECL--KEYKFYYASDVWSFGVTLYELLTHCDSSQSP--PTKFLELI 248 >5O0Y-A nrPDB Length = 579 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 71/239 (29%), Positives = 108/239 (45%), Gaps = 25/239 (10%) Query: 53 ERGEKIDENVKREIINHRSLRHPNIVRFKEVI-LTPTHLAIVMEYASGGELFERICNAGR 111 E+ E ++ RE H+ L HP IV+ + L V+EY G +L + Sbjct: 326 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 385 Query: 112 FSEDEARFFFQQLISGVSYCHAMQ--VCHRDLKLENTLL-DGSPAPRLKICDFGYSK--- 165 SE EAR Q+++ + Y + ++ + H DLK N LL +G+ +KI DFG SK Sbjct: 386 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 445 Query: 166 ----SSV----LHSQPKSTVGTPAYIAPEVLLKKEYDGKVA---DVWSCGVTLYVMLVGA 214 +SV L SQ GT Y+ PE + + K++ DVWS GV Y L G Sbjct: 446 DDSYNSVDGMELTSQ---GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGR 502 Query: 215 YPFEDPEEPKNF--RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 PF + ++ TI + VQ+ P ++PE + I R RI + ++ Sbjct: 503 KPFGHNQSQQDILQENTILKATEVQF--PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL 559 >2XS0-A nrPDB Length = 386 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 123/306 (40%), Gaps = 57/306 (18%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D VA+K + R + + KR E++ + + H N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 77 IVRFKEVILTPTH-------LAIVMEYASGGELFERICNAGRFSEDEAR--FFFQQLISG 127 I+ V TP + IVME +C + D R + Q++ G Sbjct: 87 IIGLLNV-FTPQKSLEEFQDVYIVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCG 140 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + + H+ + HRDLK N ++ LKI DFG ++++ V T Y APEV Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMVPFVVTRYYRAPEV 198 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYA 239 +L Y V D+WS G + M+ G F + + K I ++ +Q Sbjct: 199 ILGMGYKENV-DIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 240 IPDYVHISP----------------------------ECRHLISRIFVADPAKRISIPEI 271 + YV P + R L+S++ V D +KRIS+ E Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 272 RNHEWF 277 H + Sbjct: 318 LQHPYI 323 >5HVK-A nrPDB Length = 315 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 137/293 (46%), Gaps = 30/293 (10%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-GEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G FG A + +++ E++ +K + R E+ +E+ R L HPN+++F V+ Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLY 81 Query: 86 TPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L + EY GG L I + ++ + F + + SG++Y H+M + HR+L Sbjct: 82 KDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRNLNSH 141 Query: 145 NTLLDGSPAPRLKICDFGYSKSSV-LHSQPK--------------STVGTPAYIAPEVLL 189 N L+ + + + DFG ++ V +QP+ + VG P ++APE++ Sbjct: 142 NCLVREN--KNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN 199 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV--HIS 247 + YD KV DV+S G+ L ++G +P +T+ LNV+ + Y + Sbjct: 200 GRSYDEKV-DVFSFGIVL-CEIIGRV----NADPDYLPRTMDFGLNVRGFLDRYCPPNCP 253 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 P + R DP KR S ++ E +L+ L L + Q ++ D+ Sbjct: 254 PSFFPITVRCCDLDPEKRPSFVKL---EHWLETLRMHLAGHLPLGPQLEQLDR 303 >1JNK-A nrPDB Length = 423 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 123/299 (41%), Gaps = 45/299 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D + VA+K + R + + KR E++ + + H N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHA 133 I+ V L + EL + +C + D R + Q++ G+ + H+ Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 V D+WS G + M+ F + + K I ++ +Q + +YV Sbjct: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Query: 246 ISP----------------------------ECRHLISRIFVADPAKRISIPEIRNHEW 276 P + R L+S++ V DPAKRIS+ + H + Sbjct: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 >5O2C-A nrPDB Length = 380 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/296 (23%), Positives = 132/296 (44%), Gaps = 26/296 (8%) Query: 60 ENVKREIINHRSLRHPNIVRF----KEVILTPTHLAIVMEYASGGELFERICNAGRFSED 115 + K E + L+HPNIVRF + ++ + +V E + G L + Sbjct: 69 QRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPK 128 Query: 116 EARFFFQQLISGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 173 R + +Q++ G+ + H + HRDLK +N + G P +KI D G + + + S Sbjct: 129 VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFA 186 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN-FRKTIHR 232 KS +GTP ++APE + ++ YD V DV++ G+ + M YP+ + + +RK Sbjct: 187 KSVIGTPEFMAPE-MYEEHYDESV-DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG 244 Query: 233 ILNVQY-AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTM 291 I + + D PE + +I + ++R+SI ++ NH +F D + Sbjct: 245 IKPASFNKVTD-----PEVKEIIEGCIRQNKSERLSIRDLLNHAFF--------AEDTGL 291 Query: 292 TTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDL 347 + E D S +++ E G N + S +++ D E++ ++ Sbjct: 292 RVELAEEDDCSNS-SLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEM 346 >3FI2-A nrPDB Length = 353 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 123/299 (41%), Gaps = 45/299 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D + VA+K + R + + KR E++ + + H N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHA 133 I+ V L + EL + +C + D R + Q++ G+ + H+ Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 144 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 145 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 202 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 V D+WS G + M+ F + + K I ++ +Q + +YV Sbjct: 203 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 261 Query: 246 ISP----------------------------ECRHLISRIFVADPAKRISIPEIRNHEW 276 P + R L+S++ V DPAKRIS+ + H + Sbjct: 262 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 320 >5O2B-A nrPDB Length = 285 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 109/227 (48%), Gaps = 17/227 (7%) Query: 59 DENVKREIINHRSLRHPNIVRF----KEVILTPTHLAIVMEYASGGELFERICNAGRFSE 114 + K E + L+HPNIVRF + ++ + +V E + G L + Sbjct: 59 QQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKP 118 Query: 115 DEARFFFQQLISGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 172 R + +Q++ G+ + H + HRDLK +N + G P +KI D G + + + S Sbjct: 119 KVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSF 176 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN-FRKTIH 231 KS +GTP ++APE + ++ YD V DV++ G+ + M YP+ + + +RK Sbjct: 177 AKSVIGTPEFMAPE-MYEEHYDESV-DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 234 Query: 232 RILNVQY-AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 I + + D PE + +I + ++R+SI ++ NH +F Sbjct: 235 GIKPASFNKVTD-----PEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >1ZXE-A nrPDB Length = 303 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/287 (26%), Positives = 124/287 (43%), Gaps = 37/287 (12%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +E + +G G FG R+ + A+K I E+ + E++ SL H +VR+ Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRY 67 Query: 81 KEVIL-------------TPTHLAIVMEYASGGELFERICNAGRFSE-DEARFFFQQLIS 126 L + L I MEY L++ I + + DE F+Q++ Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILE 127 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-------VLHSQP------ 173 +SY H+ + HR+LK N +D S +KI DFG +K+ L SQ Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDES--RNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSD 185 Query: 174 --KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH 231 S +GT Y+A EVL + + D++S G+ + M+ YPF E N K + Sbjct: 186 NLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKKL- 241 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFV-ADPAKRISIPEIRNHEWF 277 R +++++ PD+ + I R+ + DP KR + N W Sbjct: 242 RSVSIEFP-PDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >4TPT-A nrPDB Length = 303 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 110/240 (45%), Gaps = 30/240 (12%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERG-EKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G FG A + K + +++ +K + R E+ + E+ RSL HPN+++F V+ Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 67 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 L ++ EY GG L + + + F + F + + SG++Y H+M + HRDL N Sbjct: 68 KDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHN 127 Query: 146 TLLDGSPAPRLKICDFGYS-----------------KSSVLHSQPK----STVGTPAYIA 184 L+ + + DFG S K L + + VG P ++A Sbjct: 128 CLIKLDKT--VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMA 185 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE+L K YD V D++S G+ L ++ Y +P +T+ LNV+ +V Sbjct: 186 PEMLNGKSYDETV-DIFSFGIVLCEIIGQVY-----ADPDCLPRTLDFGLNVKLFWEKFV 239 >3OMV-A nrPDB Length = 307 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 118/253 (46%), Gaps = 20/253 (7%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV---KREIINHRSLRHPNIVR 79 L IGSG+FG + + K + VAVK ++ + E + E+ R RH NI+ Sbjct: 40 LSTRIGSGSFGT--VYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILL 96 Query: 80 FKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 F +T +LAIV ++ G L++ + +F + +Q G+ Y HA + H Sbjct: 97 FMGY-MTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIH 155 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVLLKKEYD- 194 RD+K N L +KI DFG + S Q + G+ ++APEV+ ++ + Sbjct: 156 RDMKSNNIFLH--EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNP 213 Query: 195 -GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 +DV+S G+ LY ++ G P+ N R I ++ YA PD + C Sbjct: 214 FSFQSDVYSYGIVLYELMTGELPYSHI----NNRDQIIFMVGRGYASPDLSKLYKNCPKA 269 Query: 254 ISRIFVADPAKRI 266 + R+ VAD K++ Sbjct: 270 MKRL-VADCVKKV 281 >1G3N-A nrPDB Length = 326 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 18/206 (8%) Query: 20 RYELVKDIGSGNFGVARLMRD-KQSNELVAVKYI-----ERGEKIDENVKREIINH-RSL 72 +YE V +IG G +G RD K VA+K + E G + + ++ H + Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 73 RHPNIVRFKEVILTP-----THLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLI 125 HPN+VR +V T L +V E+ +++ G +E FQ L+ Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LL 130 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 185 G+ + H+ +V HRDLK +N L+ S ++K+ DFG ++ S V T Y AP Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVML 211 EVLL+ Y V D+WS G M Sbjct: 189 EVLLQSSYATPV-DLWSVGCIFAEMF 213 >4E7W-A nrPDB Length = 394 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 139/320 (43%), Gaps = 51/320 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 Y K IG+G+FGV + +S+E VA+K + + ++ RE+ R ++HPN+V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN---RELQIMRIVKHPNVVDL 97 Query: 81 KEVILT------PTHLAIVMEYASGGELFERICNAGRFSEDEA--------RFFFQQLIS 126 K + L +V+EY E + A R + + QL+ Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVP-----ETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 ++Y H++ +CHRD+K +N LLD P+ LK+ DFG +K + S + + Y APE Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLD-PPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPE 211 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL------NVQYAI 240 ++ D+WS G + ++ G P E + I ++L ++ Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQ-PLFPGESGIDQLVEIIKVLGTPSREQIKTMN 270 Query: 241 PDYV-HISPECR-----------------HLISRIFVADPAKRISIPEIRNHEWF--LKN 280 P+Y+ H P+ R LISR+ P+ R++ E H +F L+ Sbjct: 271 PNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRT 330 Query: 281 LPADLMNDNTMTTQFDESDQ 300 A + N + F+ + + Sbjct: 331 GEARMPNGRELPPLFNWTKE 350 >5NGU-A nrPDB Length = 381 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/202 (31%), Positives = 92/202 (45%), Gaps = 13/202 (6%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNI 77 RY + IG G +G+ D + VA+K I E + REI RH NI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFE----RICNAGRFSEDEARFFFQQLISGVSYCHA 133 + ++I PT + + + +L E ++ S D +F Q++ G+ Y H+ Sbjct: 103 IGINDIIRAPT-IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS 161 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 189 V HRDLK N LL+ + LKICDFG ++ + H V T Y APE++L Sbjct: 162 ANVLHRDLKPSNLLLNTTCD--LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 190 KKEYDGKVADVWSCGVTLYVML 211 + K D+WS G L ML Sbjct: 220 NSKGYTKSIDIWSVGCILAEML 241 >4QTB-A nrPDB Length = 380 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 96/202 (47%), Gaps = 13/202 (6%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNI 77 RY ++ IG G +G+ D VA+K I E + REI RH N+ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 78 VRFKEVILTPTHLAI----VMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 + ++++ T A+ +++ +L+ ++ + + S D +F Q++ G+ Y H+ Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS 160 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 189 V HRDLK N L++ + LKICDFG ++ + H V T Y APE++L Sbjct: 161 ANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 190 KKEYDGKVADVWSCGVTLYVML 211 + K D+WS G L ML Sbjct: 219 NSKGYTKSIDIWSVGCILAEML 240 >2Y4I-B nrPDB Length = 319 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 24/218 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ER-GEKIDENVKREIINHRSLRHP 75 ++ E+ + IG G FG ++ + E VA++ I ER E + KRE++ +R RH Sbjct: 33 EQLEIGELIGKGRFG--QVYHGRWHGE-VAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCHAM 134 N+V F ++P HLAI+ G L+ + +A ++ R Q+++ G+ Y HA Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFG-YSKSSVLHS-----QPKSTVGTPAYIAPEVL 188 + H+DLK +N D ++ I DFG +S S VL + + + G ++APE++ Sbjct: 150 GILHKDLKSKNVFYDNG---KVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 206 Query: 189 LKKEYD--------GKVADVWSCGVTLYVMLVGAYPFE 218 + D K +DV++ G Y + +PF+ Sbjct: 207 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >5AWM-A nrPDB Length = 394 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 125/308 (40%), Gaps = 62/308 (20%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 RY ++ IGSG G+ D + + VA+K + R + + KR +R + +V Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRA---YREFKLMKLVN 101 Query: 80 FKEVI-----LTPTH-------LAIVMEYASGGELFERICNAGRFSEDEAR--FFFQQLI 125 K +I TP + +VME +C + D R + Q++ Sbjct: 102 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQML 156 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 185 G+ + H+ + HRDLK N ++ LKI DFG ++++ V T Y AP Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 214 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQ 237 EV+L Y V D+WS G + M+ G F + + K I ++ +Q Sbjct: 215 EVILGMGYTENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 238 YAIPDYVHISP-----------------------------ECRHLISRIFVADPAKRISI 268 + +YV P + R+L+S++ V DP +RIS+ Sbjct: 274 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 333 Query: 269 PEIRNHEW 276 E HE+ Sbjct: 334 DEALKHEY 341 >2I6L-A nrPDB Length = 320 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 83/310 (26%), Positives = 123/310 (39%), Gaps = 49/310 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPN 76 RY +K +G G G+ D ++ VA+K I + ++VK REI R L H N Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP--QSVKHALREIKIIRRLDHDN 69 Query: 77 IVRFKEVILTPTHLAIVMEYASGGEL-------------FERICNAGRFSEDEARFFFQQ 123 IV+ E IL P+ + + S EL + G E+ AR F Q Sbjct: 70 IVKVFE-ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQ 128 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----T 179 L+ G+ Y H+ V HRDLK N ++ + LKI DFG ++ H K + T Sbjct: 129 LLRGLKYIHSANVLHRDLKPANLFIN-TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVT 187 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ-- 237 Y +P +LL K D+W+ G ML G F E + + + I V Sbjct: 188 KWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEE 247 Query: 238 ------YAIPDYVH----------------ISPECRHLISRIFVADPAKRISIPEIRNHE 275 IP Y+ IS E + +I P R++ E +H Sbjct: 248 DRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHP 307 Query: 276 WF-LKNLPAD 284 + + + P D Sbjct: 308 YMSIYSFPMD 317 >4Y83-A nrPDB Length = 332 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 117/261 (44%), Gaps = 21/261 (8%) Query: 25 KDIGS-----GNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 ++IGS G FG L +D ++ + +A K I +D+ ++ RH NI Sbjct: 74 RNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI----PVDQFKPSDVEIQACFRHENIAE 129 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 +L + + ME GG + E++ + G E E + + ++ G+ + H+ +V H Sbjct: 130 LYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHH 189 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLKKEYDGKVA 198 D+K N + + A + DFG S PK GT Y++PEV+L + + K A Sbjct: 190 DIKPSNIVFMSTKA---VLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTK-A 245 Query: 199 DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC----RHLI 254 D++S G TL M G P+ P++ + I++ Q P I+ +C R LI Sbjct: 246 DIYSLGATLIHMQTGTPPWVK-RYPRSAYPSYLYIIHKQ--APPLEDIADDCSPGMRELI 302 Query: 255 SRIFVADPAKRISIPEIRNHE 275 +P R ++ HE Sbjct: 303 EASLERNPNHRPRAADLLKHE 323 >3MIA-A nrPDB Length = 351 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/336 (25%), Positives = 146/336 (43%), Gaps = 55/336 (16%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREI 66 ++ P + +YE + IG G FG R +++ + VA+K + E REI Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 67 INHRSLRHPNIVRFKEVILTPTH--------LAIVMEYASGGELFERICNA-GRFSEDEA 117 + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVL--HSQP 173 + Q L++G+ Y H ++ HRD+K N L+ DG LK+ DFG +++ L +SQP Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQP 182 Query: 174 K---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM-------------------- 210 + V T Y PE+LL + G D+W G + M Sbjct: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 Query: 211 -LVGAYPFEDPEEPKNFR--KTIHRILNVQYAIPD----YVHISPECRHLISRIFVADPA 263 L G+ E N+ + + + + + D YV P LI ++ V DPA Sbjct: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPA 301 Query: 264 KRISIPEIRNHEWFLKN-LPADL--MNDNTMTTQFD 296 +RI + NH++F + +P+DL M +T+ F+ Sbjct: 302 QRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 >4C59-A nrPDB Length = 340 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/278 (27%), Positives = 126/278 (45%), Gaps = 55/278 (19%) Query: 24 VKDIGSGN-FGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRF- 80 +D+GSG + + RL+ SNE E+ + + +E+ + L HPNIV+F Sbjct: 46 AQDVGSGREYALKRLL----SNE----------EEKNRAIIQEVCFMKKLSGHPNIVQFC 91 Query: 81 -------KEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYC 131 +E ++ E G E +++ + G S D F Q V + Sbjct: 92 SAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHM 151 Query: 132 HAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-------SQPKSTV----- 177 H + + HRDLK+EN LL +K+CDFG S +++ H +Q ++ V Sbjct: 152 HRQKPPIIHRDLKVENLLLSNQGT--IKLCDFG-SATTISHYPDYSWSAQRRALVEEEIT 208 Query: 178 --GTPAYIAPEVL-LKKEYD-GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 TP Y PE++ L + G+ D+W+ G LY++ +PFED + RI Sbjct: 209 RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK--------LRI 260 Query: 234 LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +N +Y+IP + LI + +P +R+SI E+ Sbjct: 261 VNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >6DBN-A nrPDB Length = 316 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 128/280 (45%), Gaps = 27/280 (9%) Query: 24 VKDIGSGNFGVARLMR----DKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPNI 77 ++D+G G+FG L R + E VAVK + E G ++K+EI R+L H NI Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENI 99 Query: 78 VRFKEVIL--TPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAM 134 V++K + + ++ME+ G L E + N + + + + Q+ G+ Y + Sbjct: 100 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 159 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPA-YIAPEVLLK 190 Q HRDL N L++ ++KI DFG +K + + K +P + APE L++ Sbjct: 160 QYVHRDLAARNVLVESE--HQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE-------PKNFRKTIHRILNV---QYAI 240 ++ +DVWS GVTL+ +L P P + + T+ R++N + Sbjct: 218 SKF-YIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 276 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPE-IRNHEWFLK 279 P + E L+ + + P+ R S I E LK Sbjct: 277 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 316 >4OLI-A nrPDB Length = 645 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 74/237 (31%), Positives = 112/237 (47%), Gaps = 24/237 (10%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM----RDKQSNELVAVKYIER--GEKIDENV 62 P P + + ++D+G G+FG L + + E+VAVK ++ G + Sbjct: 343 PASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGW 402 Query: 63 KREIINHRSLRHPNIVRFKEVI--LTPTHLAIVMEYASGGELFERICNAGRFSEDEARF- 119 K+EI R+L H +I+++K L +VMEY G L + + R S A+ Sbjct: 403 KQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLL 459 Query: 120 -FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQPKS 175 F QQ+ G++Y H+ HR+L N LLD +KI DFG +K+ + + + Sbjct: 460 LFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVRE 517 Query: 176 TVGTPA-YIAPEVLLKKEYDGKVA-DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 +P + APE L KEY A DVWS GVTLY +L + P P F + I Sbjct: 518 DGDSPVFWYAPECL--KEYKFYYASDVWSFGVTLYELLTHCDSSQSP--PTKFLELI 570 >2W96-B nrPDB Length = 306 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 92/207 (44%), Gaps = 17/207 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEK-IDENVKREIINHRSLR- 73 + RYE V +IG G +G RD S VA+K + GE+ + + RE+ R L Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 74 --HPNIVRFKEVILTP-----THLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQL 124 HPN+VR +V T + +V E+ ++ G + + +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQF 121 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 + G+ + HA + HRDLK EN L+ +K+ DFG ++ V T Y A Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALDPVVVTLWYRA 179 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVML 211 PEVLL+ Y V D+WS G M Sbjct: 180 PEVLLQSTYATPV-DMWSVGCIFAEMF 205 >2W1I-A nrPDB Length = 326 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 108/231 (46%), Gaps = 19/231 (8%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMR----DKQSNELVAVKYIERG-EKIDENVKREII 67 P + + ++ +G GNFG + R + E+VAVK ++ E+ + +REI Sbjct: 35 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 94 Query: 68 NHRSLRHPNIVRFKEVILTP--THLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQL 124 +SL+H NIV++K V + +L ++MEY G L + + + R + + Q+ Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 154 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--- 181 G+ Y + HRDL N L++ R+KI DFG +K + + V P Sbjct: 155 CKGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTK-VLPQDKEYYKVKEPGESP 211 Query: 182 --YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 + APE L + ++ +DVWS GV LY + + P P F + I Sbjct: 212 IFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSP--PAEFMRMI 259 >3QGY-A nrPDB Length = 286 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 100/214 (46%), Gaps = 10/214 (4%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 L ++ D V++IGSG FG+ L ++ VA+K I+ G +++ E Sbjct: 19 SLHMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDDFIEEAEVMM 77 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVS 129 L HP +V+ V L + +V E+ G L + + G F+ + + G++ Sbjct: 78 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMA 137 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPE 186 Y V HRDL N L+ + +K+ DFG ++ VL Q S+ GT + +PE Sbjct: 138 YLEEACVIHRDLAARNCLVGENQV--IKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPE 194 Query: 187 VLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFED 219 V Y K +DVWS GV ++ V G P+E+ Sbjct: 195 VFSFSRYSSK-SDVWSFGVLMWEVFSEGKIPYEN 227 >2Y6O-A nrPDB Length = 291 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 103/219 (47%), Gaps = 24/219 (10%) Query: 17 DSDRYELVKDIGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 D+ ++ K IG G FG RL + VA+K ++ G + +R+ ++ S+ Sbjct: 12 DASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAG--YTDKQRRDFLSEASIM 69 Query: 74 ----HPNIVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISG 127 HPNI+ + V+ + I+ EY G L F R N GRF+ + + + SG Sbjct: 70 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRK-NDGRFTVIQLVGMLRGIGSG 128 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------ 181 + Y M HRDL N L++ + K+ DFG S+ VL P++ T Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNLV--CKVSDFGMSR--VLEDDPEAAYTTRGGKIPIR 184 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFED 219 + APE + +++ +DVWS G+ ++ VM G P+ D Sbjct: 185 WTAPEAIAYRKFT-SASDVWSYGIVMWEVMSYGERPYWD 222 >3GC9-A nrPDB Length = 370 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/290 (23%), Positives = 118/290 (40%), Gaps = 36/290 (12%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRSLRHPN 76 R + ++ +GSG +G D + + VAVK + R + RE+ + L+H N Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 88 Query: 77 IVRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 ++ +V T + + + G I + S++ +F QL+ G+ Y H Sbjct: 89 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 + + HRDLK N ++ L+I DFG ++ + + V T Y APE++L Sbjct: 149 SAGIIHRDLKPSNVAVNED--SELRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWM 204 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI-----------------HRILN 235 + + D+WS G + +L G F + ++ + H Sbjct: 205 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 264 Query: 236 VQYAIP----DYVHI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +Q P D I +P L+ R+ V D +R+S E H +F Sbjct: 265 IQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF 314 >4E20-A nrPDB Length = 290 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 22/204 (10%) Query: 24 VKDIGSGNFGVARLM----RDKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPNI 77 ++D+G G+FG L + + E+VAVK ++ G ++ +REI R+L H +I Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHI 72 Query: 78 VRFKEVI--LTPTHLAIVMEYASGGEL---FERICNAGRFSEDEARFFFQQLISGVSYCH 132 V++K + +VMEY G L R C + F QQ+ G++Y H Sbjct: 73 VKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC----VGLAQLLLFAQQICEGMAYLH 128 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQPKSTVGTPA-YIAPEVL 188 A HR L N LLD +KI DFG +K+ + + + +P + APE L Sbjct: 129 AQHYIHRALAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 186 Query: 189 LKKEYDGKVADVWSCGVTLYVMLV 212 + ++ +DVWS GVTLY +L Sbjct: 187 KECKFY-YASDVWSFGVTLYELLT 209 >5B2L-A nrPDB Length = 324 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 107/213 (50%), Gaps = 24/213 (11%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNI 77 E + ++GSG G MR +++ ++AVK + R +EN KR +++ +S P I Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN-KRILMDLDVVLKSHDCPYI 78 Query: 78 VRFKEVILTPTHLAIVMEY--ASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 V+ +T T + I ME S +L +R+ G E R + ++ V + ++ Sbjct: 79 VQCFGTFITNTDVFIAMELMGTSAEKLKKRM--QGPIPE---RILGKMTVAIVKALYYLK 133 Query: 136 ----VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL--- 188 V HRD+K N LLD ++K+CDFG S V + G AY+APE + Sbjct: 134 EKHGVIHRDVKPSNILLD--ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFED 219 K +YD + ADVWS G++L + G +P+++ Sbjct: 192 DPTKPDYDIR-ADVWSLGISLVELATGQFPYKN 223 >3IO7-A nrPDB Length = 313 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 106/222 (47%), Gaps = 19/222 (8%) Query: 22 ELVKDIGSGNFGVARLMR----DKQSNELVAVKYIERG-EKIDENVKREIINHRSLRHPN 76 + ++ +G GNFG + R + E+VAVK ++ E+ + +REI +SL+H N Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDN 90 Query: 77 IVRFKEVILTP--THLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHA 133 IV++K V + +L ++MEY G L + + + R + + Q+ G+ Y Sbjct: 91 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 150 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVL 188 + HRDL N L++ R+KI DFG +K + + V P + APE L Sbjct: 151 KRYIHRDLATRNILVENE--NRVKIGDFGLTK-VLPQDKEYYKVKEPGESPIFWYAPESL 207 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 + ++ +DVWS GV LY + + P P F + I Sbjct: 208 TESKFS-VASDVWSFGVVLYELFTYIEKSKSP--PAEFMRMI 246 >2VWV-A nrPDB Length = 302 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----RHPNIVR 79 IG+G FG RL + VA+K ++ G E +RE ++ S+ HPNI+R Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGG--YTERQRREFLSEASIMGQFEHPNIIR 81 Query: 80 FKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + V+ + I+ E+ G L F R+ N G+F+ + + + SG+ Y M Sbjct: 82 LEGVVTNSMPVMILTEFMENGALDSFLRL-NDGQFTVIQLVGMLRGIASGMRYLAEMSYV 140 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTP---AYIAPEVLLKK 191 HRDL N L++ + K+ DFG S+ +S S++G + APE + + Sbjct: 141 HRDLAARNILVNSNLV--CKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFR 198 Query: 192 EYDGKVADVWSCGVTLY-VMLVGAYPFED 219 ++ +D WS G+ ++ VM G P+ D Sbjct: 199 KFT-SASDAWSYGIVMWEVMSFGERPYWD 226 >4YHJ-A nrPDB Length = 584 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 118/264 (44%), Gaps = 19/264 (7%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKRE 65 P+ ++ R+ V +G G FG + + + ++ A K +++ GE + N KR Sbjct: 181 PVTKNTFRHYRV--LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKR- 237 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQ 123 I+ R +V T L +V+ +GG+L I N G F E A F+ + Sbjct: 238 ILEKVQSRF--VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAE 295 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 L G+ ++ +RDLK EN LLD ++I D G + + + VGT Y+ Sbjct: 296 LCCGLEDLQRERIVYRDLKPENILLDDR--GHIRISDLGLATEIPEGQRVRGRVGTVGYM 353 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 APEV+ ++Y D W G +Y M+ G PF+ +E + + RI N + Sbjct: 354 APEVVNNEKYTFS-PDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE- 411 Query: 244 VHISPECRHLISRIFVADPAKRIS 267 S + + + + +P+KR+ Sbjct: 412 -KFSEDAKSICRMLLTKNPSKRLG 434 >3EB0-A nrPDB Length = 383 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 105/237 (44%), Gaps = 45/237 (18%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 S +Y L K +G+G+FG+ + D +S + A+K + + + RE+ + L H NI Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---RELDIMKVLDHVNI 62 Query: 78 VRF-----------------------------------KEVILTPT---HLAIVMEYA-- 97 ++ K VI+ P+ +L ++MEY Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 98 SGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRL 156 + ++ + +GR + + QL V + H++ +CHRD+K +N L++ S L Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVN-SKDNTL 181 Query: 157 KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 K+CDFG +K + + + + Y APE++L D+WS G +++G Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILG 238 >6O6Q-A nrPDB Length = 335 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/298 (23%), Positives = 128/298 (42%), Gaps = 48/298 (16%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHPN 76 + YE+++ +G G + L D + E V +K ++ ++ + +KREI ++L PN Sbjct: 40 QENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKR--KKIKREISILKNLVDGPN 97 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAG------RFSEDEARFFFQQLISGVSY 130 I+ +V+ P + + G +FE I N F++ + RF+ +L+ + Y Sbjct: 98 IIAMLDVVREP-------QSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALDY 150 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 H+M + HRD+K N ++D L++ D+G ++ ++ V + + PE+L+ Sbjct: 151 SHSMGIMHRDVKPHNVMIDHDKKL-LRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVD 209 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE-------------PKNFRKTIHRI---L 234 D+WS G L M+ PF + KNF+K + + L Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 235 NVQYAIPDYVH---------------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +Y Y + +S E LI R+ D +R++ E H +F Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >3VN9-A nrPDB Length = 340 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 123/272 (45%), Gaps = 19/272 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI----INHRSLR 73 +D E + ++G G +GV MR S +++AVK I R + KR + I+ R++ Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVD 108 Query: 74 HPNIVRFKEVILTPTHLAIVMEY--ASGGELFERICNAGR-FSEDEARFFFQQLISGVSY 130 P V F + + I ME S + ++++ + G+ ED ++ + + Sbjct: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 Query: 131 CHA-MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV-- 187 H+ + V HRD+K N L++ ++K+CDFG S V G Y+APE Sbjct: 169 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 Query: 188 --LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 L +K Y K +D+WS G+T+ + + +P++ P K + + Q + Sbjct: 227 PELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 S E S+ + +R + PE+ H +F Sbjct: 284 -SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >4P5Q-A nrPDB Length = 361 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 102/217 (47%), Gaps = 24/217 (11%) Query: 17 DSDRYELVKDIGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 D+ + K +G+G FG RL + VA+K ++ G E +R+ + S+ Sbjct: 31 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG--YTEKQRRDFLGEASIM 88 Query: 74 ----HPNIVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISG 127 HPNI+R + V+ + IV EY G L F R +A +F+ + + + SG Sbjct: 89 GQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDA-QFTVIQLVGMLRGIASG 147 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------ 181 + Y M HRDL N L++ + K+ DFG S+ VL P++ T Sbjct: 148 MKYLSDMGYVHRDLAARNILINSNLV--CKVSDFGLSR--VLEDDPEAAYTTRGGKIPIR 203 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 + +PE + +++ +DVWS G+ L+ VM G P+ Sbjct: 204 WTSPEAIAYRKFT-SASDVWSYGIVLWEVMSYGERPY 239 >3FME-A nrPDB Length = 290 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 123/272 (45%), Gaps = 19/272 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI----INHRSLR 73 +D E + ++G G +GV MR S +++AVK I R + KR + I+ R++ Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVD 64 Query: 74 HPNIVRFKEVILTPTHLAIVMEY--ASGGELFERICNAGR-FSEDEARFFFQQLISGVSY 130 P V F + + I ME S + ++++ + G+ ED ++ + + Sbjct: 65 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 131 CHA-MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV-- 187 H+ + V HRD+K N L++ ++K+CDFG S V G Y+APE Sbjct: 125 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 188 --LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 L +K Y K +D+WS G+T+ + + +P++ P K + + Q + Sbjct: 183 PELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 239 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 S E S+ + +R + PE+ H +F Sbjct: 240 -SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >6E4F-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 98/207 (47%), Gaps = 22/207 (10%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 +K++G+G FGV + + + + VA+K I+ G ++ E +L H +V+ Sbjct: 35 FLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYG 93 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI-------SGVSYCHAMQ 135 V + I+ EY + G C E RF QQL+ + Y + Q Sbjct: 94 VCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 147 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKE 192 HRDL N L++ +K+ DFG S+ VL + S+VG+ + PEVL+ + Sbjct: 148 FLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 193 YDGKVADVWSCGVTLY-VMLVGAYPFE 218 + K +D+W+ GV ++ + +G P+E Sbjct: 205 FSSK-SDIWAFGVLMWEIYSLGKMPYE 230 >5ZTN-A nrPDB Length = 429 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 96/216 (44%), Gaps = 13/216 (6%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 + +P H + RYE++K IG G+FG D + ++ VA+K + ++ EI Sbjct: 88 VQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL 147 Query: 70 RSLRHP------NIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFF 121 LR N++ E H+ + E S EL ++ G FS R F Sbjct: 148 EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG-FSLPLVRKFA 206 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 ++ + H ++ H DLK EN LL +K+ DFG S H + + + + Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTYIQSRF 264 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 Y APEV+L Y G D+WS G L +L G YP Sbjct: 265 YRAPEVILGARY-GMPIDMWSLGCILAELLTG-YPL 298 >4XI2-A nrPDB Length = 446 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 22/207 (10%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 +K++G+G FGV + + + + VA+K I G ++ E +L H +V+ Sbjct: 191 FLKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYG 249 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI-------SGVSYCHAMQ 135 V + I+ EY + G C E RF QQL+ + Y + Q Sbjct: 250 VCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 303 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKE 192 HRDL N L++ +K+ DFG S+ VL + S+VG+ + PEVL+ + Sbjct: 304 FLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMYSK 360 Query: 193 YDGKVADVWSCGVTLY-VMLVGAYPFE 218 + K +D+W+ GV ++ + +G P+E Sbjct: 361 FSSK-SDIWAFGVLMWEIYSLGKMPYE 386 >5Y86-A nrPDB Length = 588 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 66/224 (29%), Positives = 99/224 (44%), Gaps = 22/224 (9%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 + +P H + RYE++K IG G+FG + D + + VA+K + ++ EI Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI--- 254 Query: 70 RSLRH---------PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEAR 118 R L H N++ E H+ + E S +L+E I FS R Sbjct: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVR 313 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-V 177 F Q ++ + H ++ H DLK EN LL K+ DFG SS Q T + Sbjct: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYI 370 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFED 219 + Y APE++L Y + D+WS G L +L G +P ED Sbjct: 371 QSRFYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGED 413 >3NIE-A nrPDB Length = 429 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/227 (28%), Positives = 98/227 (43%), Gaps = 37/227 (16%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKID-ENVKREIINHRSLRHP 75 D YE+ IG G++G L DK +N+ VA+K + R + ID + + REI L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 76 NIVRFKEVI-----LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 I+R ++I L L IV+E A +L + +E + L+ G + Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS------------------------ 166 H + HRDLK N LL+ + +KICDFG +++ Sbjct: 147 IHESGIIHRDLKPANCLLNQDCS--VKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 167 --SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 L Q S V T Y APE++L +E D+WS G +L Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >4JLC-A nrPDB Length = 657 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 67/238 (28%), Positives = 108/238 (45%), Gaps = 23/238 (9%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 S+ L+ DI G G R K++ +L AVK I +D + RE + L Sbjct: 6 SNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQM-REFEVLKKLN 64 Query: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 H NIV+ E T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 65 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 ++ + HRD+K N + DG K+ DFG ++ Q S GT Y+ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 182 Query: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 183 PDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 240 >4HZS-A nrPDB Length = 341 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 76/306 (24%), Positives = 136/306 (44%), Gaps = 33/306 (10%) Query: 23 LVKDIGSGNFGVARLMR-DKQSNELVAVKY-------IERGEKIDENVKREIINHRSLRH 74 L++ +G G+FGV R D S + V+V + + E +D+ + RE+ SL H Sbjct: 16 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI-REVNAMHSLDH 74 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHA 133 N++R V+LTP + +V E A G L +R+ + G F + Q+ G+ Y + Sbjct: 75 RNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLES 133 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-------SVLHSQPKSTVGTPAYIAPE 186 + HRDL N LL + +KI DFG ++ V+ K A+ APE Sbjct: 134 KRFIHRDLAARNLLL--ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF---AWCAPE 188 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L + + +D W GVTL+ M ++P N + +H+I +P Sbjct: 189 SLKTRTFS-HASDTWMFGVTLWEMFTYG---QEPWIGLNGSQILHKIDKEGERLPRPEDC 244 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIE 306 + +++ + + P R + +R+ + L+ P D+ F+E D+ + Sbjct: 245 PQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDM----RALQDFEEPDKLHIQMN 298 Query: 307 EIMQII 312 +++ +I Sbjct: 299 DVITVI 304 >4Y93-A nrPDB Length = 446 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 22/207 (10%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 +K++G+G FGV + + + + VA+K I+ G ++ E +L H +V+ Sbjct: 192 FLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYG 250 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI-------SGVSYCHAMQ 135 V + I+ EY + G C E RF QQL+ + Y + Q Sbjct: 251 VCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 304 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKE 192 HRDL N L++ +K+ DFG ++ VL + S+ G+ + +PEVL+ + Sbjct: 305 FLHRDLAARNCLVNDQGV--VKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVLMYSK 361 Query: 193 YDGKVADVWSCGVTLY-VMLVGAYPFE 218 + K +D+W+ GV ++ + +G P+E Sbjct: 362 FSSK-SDIWAFGVLMWEIYSLGKMPYE 387 >4CRL-A nrPDB Length = 406 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 81/319 (25%), Positives = 134/319 (42%), Gaps = 61/319 (19%) Query: 21 YELVKDIGSGNFG--VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 YE K +G G +G +D + ++ A+K IE G I + REI R L+HPN++ Sbjct: 25 YEGCK-VGRGTYGHVYKAKRKDGKDDKDYALKQIE-GTGISMSACREIALLRELKHPNVI 82 Query: 79 RFKEVILTPT--HLAIVMEYASGGEL----FERICNAGR----FSEDEARFFFQQLISGV 128 ++V L+ + ++ +YA F R A + + Q++ G+ Sbjct: 83 SLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGI 142 Query: 129 SYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKS----TVGTPAY 182 Y HA V HRDLK N L+ +G R+KI D G+++ +P + V T Y Sbjct: 143 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWY 202 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVML-----------------------------VG 213 APE+LL + K D+W+ G +L V Sbjct: 203 RAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVM 262 Query: 214 AYP----FED----PEEP---KNFRKTIHRILN-VQYAIPDYVHISPECRHLISRIFVAD 261 +P +ED PE K+FR+ + + ++Y V + HL+ ++ D Sbjct: 263 GFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD 322 Query: 262 PAKRISIPEIRNHEWFLKN 280 P KRI+ + +FL++ Sbjct: 323 PIKRITSEQAMQDPYFLED 341 >3KUL-B nrPDB Length = 325 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 102/217 (47%), Gaps = 24/217 (11%) Query: 17 DSDRYELVKDIGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 ++ R + K IGSG+ G RL Q + VA+K ++ G E +R+ ++ S+ Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG--YTERQRRDFLSEASIM 104 Query: 74 ----HPNIVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISG 127 HPNI+R + V+ IV EY G L F R + G+F+ + + + +G Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR-THDGQFTIMQLVGMLRGVGAG 163 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------ 181 + Y + HRDL N L+D + K+ DFG S+ VL P + T Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNLV--CKVSDFGLSR--VLEDDPDAAYTTTGGKIPIR 219 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 + APE + + + +DVWS GV ++ V+ G P+ Sbjct: 220 WTAPEAIAFRTFS-SASDVWSFGVVMWEVLAYGERPY 255 >4O2Z-A nrPDB Length = 377 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 133/312 (42%), Gaps = 53/312 (16%) Query: 6 VSG-PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKY---IERGEKIDEN 61 VSG P ++P +Y L+K +G G +G+A D + E V++K + R + + Sbjct: 36 VSGSPFEVP-----SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 62 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELF---------ERICNAGR- 111 V REI R H N++ IL P + EY S +++ + R Sbjct: 91 VLREIDMMRFFHHENLLNVVN-ILPP----LKREYHSFEDVYVVTPLMDVDMNVVLRSRQ 145 Query: 112 -FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVL 169 E ++F Q++ G+ Y H+ V HRDLK N + + S LKI DFG S+S V Sbjct: 146 VLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNIS--CELKIIDFGLSRSVDVP 203 Query: 170 HSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM-----------------LV 212 +S+ V T Y PE+LL+ D+WS G M ++ Sbjct: 204 YSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMI 263 Query: 213 GAYPFEDPEEPKNFRKTIHRI-------LNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 + + P R+ + ++ LN+ +P + E +S+++ DP+KR Sbjct: 264 AQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAG-NTEGIDFLSKMWTLDPSKR 322 Query: 266 ISIPEIRNHEWF 277 + ++ H + Sbjct: 323 PTAADMLAHPYL 334 >3N9X-A nrPDB Length = 432 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 101/228 (44%), Gaps = 34/228 (14%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKID-ENVKREIINHRS 71 +H D Y + IG G++G L DK + + VA+K + R + ID + + REI Sbjct: 22 VHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNR 81 Query: 72 LRHPNIVRFKEVI-----LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 126 L+ I+R ++I L L IV+E A +L + +E+ + L+ Sbjct: 82 LKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLL 140 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-------------------- 166 G ++ H + HRDLK N LL+ + +K+CDFG +++ Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCS--VKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 167 ---SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 L Q S V T Y APE++L +E K D+WS G +L Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >5HI2-A nrPDB Length = 283 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 115/256 (44%), Gaps = 24/256 (9%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 IGSG+FG + + K + VAVK + + + K E+ R RH NI+ F Sbjct: 28 IGSGSFGT--VYKGKWHGD-VAVKMLTPQQL--QAFKNEVGVLRKTRHVNILLFMGYSTK 82 Query: 87 PTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 P LAIV ++ G L+ + + +F + +Q G+ Y HA + HRDLK N Sbjct: 83 P-QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN 141 Query: 146 TLLDGSPAPRLKICDFGY----SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD--GKVAD 199 L +KI DFG S+ S H Q + G+ ++APEV+ ++ + +D Sbjct: 142 IFLHEDNT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVIRMQDSNPYSFQSD 198 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC----RHLIS 255 V++ G+ LY ++ G P+ + N R I ++ PD + C + L++ Sbjct: 199 VYAFGIVLYELMTGQLPYSNI----NNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMA 254 Query: 256 RIFVADPAKRISIPEI 271 +R S P I Sbjct: 255 ECLKKKRDERPSFPRI 270 >4OW8-A nrPDB Length = 283 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 91/211 (43%), Gaps = 14/211 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 69 Query: 74 HPNIVR---FKEVILTPTHLA--IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + E + +VME +G L + GR S A +Q + Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 129 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 130 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 L + +DV+S GV Y + G PF Sbjct: 188 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 217 >6B2Q-A nrPDB Length = 317 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 91/211 (43%), Gaps = 14/211 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 90 Query: 74 HPNIVR---FKEVILTPTHLA--IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + E + +VME +G L + GR S A +Q + Sbjct: 91 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 150 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 151 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 L + +DV+S GV Y + G PF Sbjct: 209 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 238 >1U54-B nrPDB Length = 291 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 76/298 (25%), Positives = 131/298 (43%), Gaps = 30/298 (10%) Query: 5 AVSGPMD-LPIMHDSDRYELVKDIGSGNFGVARLMR-DKQSNELVAVKY-------IERG 55 A GP+ L + L++ +G G+FGV R D S + V+V + + Sbjct: 3 AGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQP 62 Query: 56 EKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSE 114 E +D+ + RE+ SL H N++R V+LTP + +V E A G L +R+ + G F Sbjct: 63 EAMDDFI-REVNAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLL 120 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-------S 167 + Q+ G+ Y + + HRDL N LL + +KI DFG ++ Sbjct: 121 GTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLL--ATRDLVKIGDFGLMRALPQNDDHY 178 Query: 168 VLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFR 227 V+ K A+ APE L + + +D W GVTL+ M ++P N Sbjct: 179 VMQEHRKVPF---AWCAPESLKTRTFS-HASDTWMFGVTLWEMFTYG---QEPWIGLNGS 231 Query: 228 KTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADL 285 + +H+I +P + +++ + + P R + +R+ + L+ P D+ Sbjct: 232 QILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDM 287 >4EUT-A nrPDB Length = 396 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 108/238 (45%), Gaps = 23/238 (9%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 S+ L+ DI G G R K++ +L A+K I +D + RE + L Sbjct: 7 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 65 Query: 74 HPNIVRFKEVI--LTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 H NIV+ + T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 ++ + HR++K N + DG K+ DFG ++ Q S GT Y+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 241 >6NT9-A nrPDB Length = 742 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/238 (27%), Positives = 108/238 (45%), Gaps = 23/238 (9%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 S+ L+ DI G G R K++ +L A+K I +D + RE + L Sbjct: 5 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 63 Query: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 H NIV+ E T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 ++ + HR++K N + DG K+ DFG ++ Q S GT Y+ Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 181 Query: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 182 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 >5HIE-A nrPDB Length = 302 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 109/240 (45%), Gaps = 20/240 (8%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 IGSG+FG + + K + VAVK + + + K E+ R RH NI+ F Sbjct: 44 IGSGSFGT--VYKGKWHGD-VAVKMLTPQQL--QAFKNEVGVLRKTRHVNILLFMGYSTK 98 Query: 87 PTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 P LAIV ++ G L+ + +F + +Q G+ Y HA + HRDLK N Sbjct: 99 P-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNN 157 Query: 146 TLLDGSPAPRLKICDFGY----SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD--GKVAD 199 L +KI DFG S+ S H Q + G+ ++APEV+ ++ + +D Sbjct: 158 IFLHEDLT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVIRMQDKNPYSFQSD 214 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFV 259 V++ G+ LY ++ G P+ + N R I ++ Y PD + C + R+ Sbjct: 215 VYAFGIVLYELMTGQLPYSNI----NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 270 >4EUU-A nrPDB Length = 319 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 108/238 (45%), Gaps = 23/238 (9%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 S+ L+ DI G G R K++ +L A+K I +D + RE + L Sbjct: 7 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 65 Query: 74 HPNIVRFKEVI--LTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 H NIV+ + T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 ++ + HR++K N + DG K+ DFG ++ Q S GT Y+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLH 183 Query: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 241 >3OZ6-A nrPDB Length = 388 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 96/228 (42%), Gaps = 28/228 (12%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSL 72 H +YELVK +G G +G+ D+++ E+VAVK I + + + REI+ L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 73 R-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 H NIV V+ + + + + A ++ QLI + Y Sbjct: 66 SGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYL 125 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKST---------- 176 H+ + HRD+K N LL+ +K+ DFG S+S V ++ P S Sbjct: 126 HSGGLLHRDMKPSNILLNAE--CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 177 -------VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 V T Y APE+LL K D+WS G L +L G F Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIF 231 >4X3F-A nrPDB Length = 337 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 91/211 (43%), Gaps = 14/211 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 70 Query: 74 HPNIVR---FKEVILTPTHLA--IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + E + +VME +G L + GR S A +Q + Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 130 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 131 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 L + +DV+S GV Y + G PF Sbjct: 189 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 218 >3HMP-A nrPDB Length = 342 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 132/299 (44%), Gaps = 47/299 (15%) Query: 21 YELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENV---KREI--INHRSLRH 74 Y ++K IGSG V +++ +K+ ++ A+KY+ E ++ + + EI +N Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK--QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 186 + H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 175 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 187 VL----------LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 + K +DVWS G LY M G PF ++ N +H I++ Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 283 Query: 237 QYAI--PDYVHISPE--CRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I PD PE + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 284 NHEIEFPDI----PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 338 >4YFF-A nrPDB Length = 311 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 94/203 (46%), Gaps = 18/203 (8%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPNIVRFKE 82 IGSG+FG ++ + + N++VA+K ++ RE+ L HP +++F Sbjct: 50 IGSGSFG--KVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 107 Query: 83 VILT-PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ-QLISGVSYCHAMQ--VCH 138 L P+ AIV +Y SGG LF + R + +++ + G+ Y H + + H Sbjct: 108 ACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIH 167 Query: 139 RDLKLENTLL--DGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 RDL N LL DG + DFG S+ S+ G ++APEV + Sbjct: 168 RDLNSHNILLYEDGHAV----VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRY 223 Query: 195 GKVADVWSCGVTLYVMLVGAYPF 217 ADV+S + L+ +L G PF Sbjct: 224 TIKADVFSYALCLWEILTGEIPF 246 >5L6P-A nrPDB Length = 298 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 99/211 (46%), Gaps = 26/211 (12%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPNIVR 79 IG+G FG RL + + VA+K ++ G E +R+ ++ S+ HPNI+R Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG--YTERQRRDFLSEASIMGQFDHPNIIR 84 Query: 80 FKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + V+ + I+ E+ L F R+ N G+F+ + + + +G+ Y M Sbjct: 85 LEGVVTKSRPVMILTEFMENCALDSFLRL-NDGQFTVIQLVGMLRGIAAGMKYLSEMNYV 143 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--------YIAPEVLL 189 HRDL N L++ + K+ DFG S+ L P T + + APE + Sbjct: 144 HRDLAARNILVNSNLV--CKVSDFGLSR--FLEDDPSDPTYTSSLGGKIPIRWTAPEAIA 199 Query: 190 KKEYDGKVADVWSCGVTLY-VMLVGAYPFED 219 +++ +DVWS G+ ++ VM G P+ D Sbjct: 200 YRKFT-SASDVWSYGIVMWEVMSYGERPYWD 229 >6GVJ-A nrPDB Length = 429 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 132/299 (44%), Gaps = 47/299 (15%) Query: 21 YELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENV---KREI--INHRSLRH 74 Y ++K IGSG V +++ +K+ ++ A+KY+ E ++ + + EI +N Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKK--QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 203 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 186 + H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 263 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 187 VL----------LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 + K +DVWS G LY M G PF ++ N +H I++ Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 371 Query: 237 QYAI--PDYVHISPE--CRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I PD PE + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 372 NHEIEFPDI----PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 426 >4E93-A nrPDB Length = 377 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 118/280 (42%), Gaps = 36/280 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIIN 68 P D +++ D L + IG GNFG R + N LVAVK E + ++K + + Sbjct: 105 PKDKWVLNHED-LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR--ETLPPDLKAKFLQ 161 Query: 69 H----RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 + HPNIVR V + IVME GG+ + G AR + L Sbjct: 162 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG------ARLRVKTL 215 Query: 125 I-------SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKS 175 + +G+ Y + HRDL N L+ LKI DFG S+ +++ Sbjct: 216 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNV--LKISDFGMSREEADGVYAASGG 273 Query: 176 TVGTPA-YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFED--PEEPKNFRKTIH 231 P + APE L Y + +DVWS G+ L+ +GA P+ + ++ + F + Sbjct: 274 LRQVPVKWTAPEALNYGRYSSE-SDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG 332 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 R L PD V L+ + + +P +R S I Sbjct: 333 R-LPCPELCPDAVF------RLMEQCWAYEPGQRPSFSTI 365 >4CSV-A nrPDB Length = 275 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 93/203 (45%), Gaps = 14/203 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 L + +GSG FG + + N VAVK ++ G E +E + L+HPN+V+ Sbjct: 15 LERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLKHPNLVQLYG 74 Query: 83 VILTPTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRD 140 V + I+ EY S G L + R C + Q+ SG++Y + HRD Sbjct: 75 VCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRD 134 Query: 141 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLKKEYDG 195 L N L+ + +K+ DFG ++ L ++ + T A + APE + + Sbjct: 135 LAARNCLVGENNV--VKVADFGLAR---LINEDEYTARAGAKFPIKWTAPEAISYNRFSI 189 Query: 196 KVADVWSCGVTLY-VMLVGAYPF 217 K +DVW+ G+ L+ + G P+ Sbjct: 190 K-SDVWAFGILLWEIFTYGQVPY 211 >3RP9-A nrPDB Length = 458 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 106/246 (43%), Gaps = 41/246 (16%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKID- 59 +P S P DRYE+ IG+G++G DK +VA+K I R + ID Sbjct: 37 KPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDC 96 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTP-----THLAIVMEYASGGELFERICNAGRF-S 113 + + REI L H ++V+ ++++ L +V+E A F+++ + + Sbjct: 97 KRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSD--FKKLFRTPVYLT 154 Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-------- 165 E + L+ GV Y H+ + HRDLK N L++ + +K+CDFG ++ Sbjct: 155 ELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCS--VKVCDFGLARTVDYPENG 212 Query: 166 --------------------SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGV 205 + L Q V T Y APE++L +E + DVWS G Sbjct: 213 NSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGC 272 Query: 206 TLYVML 211 +L Sbjct: 273 IFAELL 278 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 S + HL+ R+ V +P KRI+I E H +F Sbjct: 370 SADAIHLLKRMLVFNPNKRITINECLAHPFF 400 >2WO6-A nrPDB Length = 382 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 94/222 (42%), Gaps = 14/222 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREII------NHRSL 72 DRYE+ IG G+FG D+ E VA+K I+ + + E+ H + Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSY 130 IV K + HL +V E S L++ R N S + R F QQ+ + + + Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLS-YNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 131 CHA--MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + + H DLK EN LL +KI DFG S L + + + Y +PEVL Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFG--SSCQLGQRIYQYIQSRFYRSPEVL 230 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 L YD + D+WS G L M G F E K + Sbjct: 231 LGMPYDLAI-DMWSLGCILVEMHTGEPLFSGANEVDQMNKIV 271 >5AP3-A nrPDB Length = 313 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 132/299 (44%), Gaps = 47/299 (15%) Query: 21 YELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENV---KREI--INHRSLRH 74 Y ++K IGSG V +++ +K+ ++ A+KY+ E ++ + + EI +N Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKK--QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 87 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 186 + H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 147 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 198 Query: 187 VL----------LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 + K +DVWS G LY M G PF ++ N +H I++ Sbjct: 199 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 255 Query: 237 QYAI--PDYVHISPE--CRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I PD PE + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 256 NHEIEFPDI----PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 310 >3ALO-A nrPDB Length = 327 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 69/273 (25%), Positives = 118/273 (43%), Gaps = 31/273 (11%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-----INHRSLRHPNIVRF 80 +IG G +G M K S +++AVK I +DE ++++ + RS P IV+F Sbjct: 29 EIGRGAYGSVNKMVHKPSGQIMAVKRIR--STVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA------- 133 + I ME S F++ D+ ++++ ++ Sbjct: 87 YGALFREGDCWICMELMSTS--FDKFYKYVYSVLDDV--IPEEILGKITLATVKALNHLK 142 Query: 134 --MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL--- 188 +++ HRD+K N LLD S +K+CDFG S V G Y+APE + Sbjct: 143 ENLKIIHRDIKPSNILLDRSG--NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 200 Query: 189 -LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN--VQYAIPDYVH 245 ++ YD + +DVWS G+TLY + G +P+ P+ F + + Q + + Sbjct: 201 ASRQGYDVR-SDVWSLGITLYELATGRFPY--PKWNSVFDQLTQVVKGDPPQLSNSEERE 257 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 SP + ++ D +KR E+ H + L Sbjct: 258 FSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 290 >2WTK-B nrPDB Length = 373 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 18/215 (8%) Query: 21 YELVKDIGSG--NFGVARLMRDKQSNELVAVKYIERGEKIDENV---KREIINHRSLRHP 75 YEL+ IG G + L R K + E V V+ I +E V + E+ + HP Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYCHA 133 NIV ++ + L +V + + G + IC +E + Q ++ + Y H Sbjct: 71 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 130 Query: 134 MQVCHRDLKLENTLL--DGSP-----APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 M HR +K + L+ DG L + G + V+H PK +V +++PE Sbjct: 131 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG-QRQRVVHDFPKYSVKVLPWLSPE 189 Query: 187 VLLK--KEYDGKVADVWSCGVTLYVMLVGAYPFED 219 VL + + YD K +D++S G+T + G PF+D Sbjct: 190 VLQQNLQGYDAK-SDIYSVGITACELANGHVPFKD 223 >6O8B-A nrPDB Length = 665 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 23/238 (9%) Query: 18 SDRYELVKDI-GSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKREIINHRSLR 73 S+ L+ DI G G R K++ +L A+K I +D + RE + L Sbjct: 13 SNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM-REFEVLKKLN 71 Query: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELF---ERICNAGRFSEDEARFFFQQLISGV 128 H NIV+ E T H ++ME+ G L+ E NA E E + ++ G+ Sbjct: 72 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 129 SYCHAMQVCHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 ++ + HR++K N + DG K+ DFG ++ Q GT Y+ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVELYGTEEYLH 189 Query: 185 PEV----LLKKEYD---GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 P++ +L+K++ G D+WS GVT Y G+ PF E P+ ++ +++I+ Sbjct: 190 PDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 247 >5X8I-B nrPDB Length = 346 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 87/325 (26%), Positives = 131/325 (40%), Gaps = 70/325 (21%) Query: 18 SDRYELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREI--INHRSLRH 74 S RYE+V +G G FG V + K VAVK ++ ++ E + EI + H + Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTD 71 Query: 75 PN----IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGV 128 PN V+ E H+ IV E G ++ I G F D R Q+ V Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 129 SYCHAMQVCHRDLKLENTLL---DGSPA--------------PRLKICDFGYSKSSVLHS 171 ++ H+ ++ H DLK EN L D + A P +K+ DFG S+ Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SATYDD 187 Query: 172 QPKST-VGTPAYIAPEVLLKKEYDGKVADVWSCGVTL--YVMLVGAYPFEDPEE------ 222 + ST V T Y APEV+L + + DVWS G L Y + +P D +E Sbjct: 188 EHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMME 246 Query: 223 ------PKNFRKTIHRILNVQYAIPDY-------VHISPECR-----------------H 252 PK+ + + + D+ ++S C+ Sbjct: 247 RILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFD 306 Query: 253 LISRIFVADPAKRISIPEIRNHEWF 277 LI ++ DPAKRI++ E H +F Sbjct: 307 LIQKMLEYDPAKRITLREALKHPFF 331 >3PLS-A nrPDB Length = 298 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 117/257 (45%), Gaps = 31/257 (12%) Query: 27 IGSGNFGV---ARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRFK 81 IG G+FGV + Q+ A+K + R ++ E RE + R L HPN++ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 88 Query: 82 EVILTPTHLA-IVMEYASGGELFERICNAGRF-SEDEARFFFQQLISGVSYCHAMQVCHR 139 ++L P L +++ Y G+L + I + R + + F Q+ G+ Y + HR Sbjct: 89 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHR 148 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTPAYIAPEVLLKK 191 DL N +LD S +K+ DFG ++ S H + V + A E L Sbjct: 149 DLAARNCMLDESFT--VKVADFGLARDILDREYYSVQQHRHARLPV---KWTALESLQTY 203 Query: 192 EYDGKVADVWSCGVTLYVMLV-GAYPFE--DPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K +DVWS GV L+ +L GA P+ DP + +F R+ +Y PD ++ Sbjct: 204 RFTTK-SDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYC-PDSLY--- 258 Query: 249 ECRHLISRIFVADPAKR 265 ++ + + ADPA R Sbjct: 259 ---QVMQQCWEADPAVR 272 >5UIU-A nrPDB Length = 323 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 97/209 (46%), Gaps = 17/209 (8%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIE-----RGEKIDENVKREIINHRSLRHPNIVRFK 81 +G G FGV + + +N VAVK + E++ + +EI +H N+V Sbjct: 55 MGEGGFGV--VYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 82 EVILTPTHLAIVMEYASGGELFERI-CNAGR--FSEDEARFFFQQLISGVSYCHAMQVCH 138 L +V Y G L +R+ C G S Q +G+++ H H Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 172 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAYIAPEVLLKKEYDG 195 RD+K N LLD A KI DFG +++S +Q T VGT AY+APE L+ E Sbjct: 173 RDIKSANILLD--EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA-LRGEITP 229 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPK 224 K +D++S GV L ++ G ++ EP+ Sbjct: 230 K-SDIYSFGVVLLEIITGLPAVDEHREPQ 257 >2ZMD-A nrPDB Length = 390 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 131/299 (43%), Gaps = 47/299 (15%) Query: 21 YELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENV---KREI--INHRSLRH 74 Y ++K IGSG V +++ +K+ ++ A+KY+ E ++ + + EI +N Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK--QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 186 + H DLK N L+ DG LK+ DFG + QP +T VG Y+ PE Sbjct: 175 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 187 VL----------LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 + K +DVWS G LY M G PF ++ N +H I++ Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 283 Query: 237 QYAI--PDYVHISPE--CRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I PD PE + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 284 NHEIEFPDI----PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 338 >3DKO-A nrPDB Length = 318 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 105/219 (47%), Gaps = 24/219 (10%) Query: 17 DSDRYELVKDIGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 D+ ++ + IG+G FG RL + + VA+K ++ G E +R+ + S+ Sbjct: 41 DASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG--YTEKQRRDFLCEASIM 98 Query: 74 ----HPNIVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISG 127 HPN+V + V+ + IV+E+ G L F R + G+F+ + + + +G Sbjct: 99 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRK-HDGQFTVIQLVGMLRGIAAG 157 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------ 181 + Y M HRDL N L++ + K+ DFG S+ V+ P++ T Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNLV--CKVSDFGLSR--VIEDDPEAVYTTTGGKIPVR 213 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFED 219 + APE + +++ +DVWS G+ ++ VM G P+ D Sbjct: 214 WTAPEAIQYRKFT-SASDVWSYGIVMWEVMSYGERPYWD 251 >4PDO-A nrPDB Length = 299 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 100/209 (47%), Gaps = 23/209 (11%) Query: 25 KDIGSGNFG-VARLMRDKQSNEL---VAVKYIERG----EKIDENVKREIINHRSLRHPN 76 K IG+G FG V + M S + VA+K ++ G +++D + I+ S H N Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFS--HHN 97 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + VI + I+ EY G L + + G FS + + + +G+ Y M Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN 157 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLL 189 HRDL N L++ + K+ DFG S+ VL P++T T + APE + Sbjct: 158 YVHRDLAARNILVNSNLV--CKVSDFGLSR--VLEDDPEATYTTSGGKIPIRWTAPEAIS 213 Query: 190 KKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 +++ +DVWS G+ ++ VM G P+ Sbjct: 214 YRKFT-SASDVWSFGIVMWEVMTYGERPY 241 >2R2P-A nrPDB Length = 295 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 96/206 (46%), Gaps = 22/206 (10%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPNIVR 79 IG+G FG RL + VA+K ++ G E +R+ + S+ HPNI+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG--YTEKQRRDFLGEASIMGQFDHPNIIH 87 Query: 80 FKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + V+ + IV EY G L + N G+F+ + + + +G+ Y M H Sbjct: 88 LEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVH 147 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLLKKE 192 RDL N L++ + K+ DFG S+ VL P++ T + APE + ++ Sbjct: 148 RDLAARNILINSNLV--CKVSDFGLSR--VLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 203 Query: 193 YDGKVADVWSCGVTLY-VMLVGAYPF 217 + +DVWS G+ ++ V+ G P+ Sbjct: 204 FT-SASDVWSYGIVMWEVVSYGERPY 228 >4HVI-A nrPDB Length = 314 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 94/213 (44%), Gaps = 17/213 (7%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMR----DKQSNELVAVKYIER-GEKIDENVKREII 67 P + + + + +G GNFG L R + LVAVK ++ G + +REI Sbjct: 4 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 63 Query: 68 NHRSLRHPNIVRFKEVILTPTH--LAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQL 124 ++L IV+++ V P L +VMEY G L + + + R + Q+ Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 123 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--- 181 G+ Y + + HRDL N L++ +KI DFG +K L + V P Sbjct: 124 CKGMEYLGSRRCVHRDLAARNILVESE--AHVKIADFGLAKLLPL-DKDYYVVREPGQSP 180 Query: 182 --YIAPEVLLKKEYDGKVADVWSCGVTLYVMLV 212 + APE L + + +DVWS GV LY + Sbjct: 181 IFWYAPESLSDNIFS-RQSDVWSFGVVLYELFT 212 >4LFI-A nrPDB Length = 374 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 43/169 (25%), Positives = 81/169 (47%), Gaps = 6/169 (3%) Query: 51 YIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHL--AIVMEYASGGELFERICN 108 Y + E + + ++ I + H NI+ ++I P A+V EY + RI Sbjct: 109 YTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILY 166 Query: 109 AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 168 + ++ E RF+ +L+ + YCH+M + HRD+K N ++D +L++ D+G ++ Sbjct: 167 P-KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYH 224 Query: 169 LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 225 VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 >1U59-A nrPDB Length = 287 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/213 (32%), Positives = 100/213 (46%), Gaps = 22/213 (10%) Query: 26 DIGSGNFGVAR----LMRDKQSNELVAVKYIERG-EKID-ENVKREIINHRSLRHPNIVR 79 ++G GNFG R MR KQ + VA+K +++G EK D E + RE L +P IVR Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 74 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCHAMQV 136 V L +VME A GG L + + G+ E Q+ G+ Y Sbjct: 75 LIGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNF 131 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLKKE 192 HRDL N LL KI DFG SK+ + +S P + APE + ++ Sbjct: 132 VHRDLAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 189 Query: 193 YDGKVADVWSCGVTLYVML-VGAYPFEDPEEPK 224 + + +DVWS GVT++ L G P++ + P+ Sbjct: 190 FSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPE 221 >1JPA-A nrPDB Length = 312 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 96/211 (45%), Gaps = 26/211 (12%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPNIVR 79 IG+G FG L + VA+K ++ G E +R+ ++ S+ HPN++ Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG--YTEKQRRDFLSEASIMGQFDHPNVIH 98 Query: 80 FKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + V+ T + I+ E+ G L F R N G+F+ + + + +G+ Y M Sbjct: 99 LEGVVTKSTPVMIITEFMENGSLDSFLR-QNDGQFTVIQLVGMLRGIAAGMKYLADMNYV 157 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--------YIAPEVLL 189 HRDL N L++ + K+ DFG S+ L T A + APE + Sbjct: 158 HRDLAARNILVNSNLV--CKVSDFGLSR--FLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 213 Query: 190 KKEYDGKVADVWSCGVTLY-VMLVGAYPFED 219 +++ +DVWS G+ ++ VM G P+ D Sbjct: 214 YRKFT-SASDVWSYGIVMWEVMSYGERPYWD 243 >5TE0-A nrPDB Length = 347 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/276 (25%), Positives = 112/276 (40%), Gaps = 42/276 (15%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVIL 85 + G F + L+R + + E + KREI R L H NIV + + + Sbjct: 27 LAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSI 86 Query: 86 TPT------HLAIVMEYASGGE---LFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 + I+M++ GG+ L + G F+E+E F V+ H + Sbjct: 87 NNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVARLHQCKT 145 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTPAYIAP 185 + HRDLK+EN LL +CDFG + + + Q + T +Y AP Sbjct: 146 PIIHRDLKVENILLHDR--GHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 203 Query: 186 EVLLKKEYDGKV----ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 E++ Y GK+ AD+W+ G LY + PF + + I + + IP Sbjct: 204 EMV--NLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA---------ICDGNFTIP 252 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 D S + LI + DP KR P+I +F Sbjct: 253 DNSRYSQDMHCLIRYMLEPDPDKR---PDIYQVSYF 285 >5AMN-A nrPDB Length = 299 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 118/269 (43%), Gaps = 39/269 (14%) Query: 23 LVKDIGSGNFG-----VARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHP 75 L K +G G FG A ++ + VAVK ++ E ++ E + + HP Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 86 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGEL--FERIC-NAGRFSEDEARF-------FFQQLI 125 ++++ L +++EYA G L F R G DE F Q+ Sbjct: 87 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK------SSVLHSQPKSTVGT 179 G+ Y M++ HRDL N L+ + ++KI DFG S+ S V SQ + V Sbjct: 147 QGMQYLAEMKLVHRDLAARNILV--AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV-- 202 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPKNFRKTIHRILNV 236 ++A E L Y + +DVWS GV L+ ++ +G YP PE N KT HR+ Sbjct: 203 -KWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER- 259 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKR 265 PD + S E L+ + + +P KR Sbjct: 260 ----PD--NCSEEMYRLMLQCWKQEPDKR 282 >4LQP-A nrPDB Length = 508 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 44/108 (40%), Positives = 61/108 (56%), Gaps = 10/108 (9%) Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF--EDPEEPKNFRKTIHR 232 STVGTP YIAPE+ L + Y G+ D WS G +Y L+G PF E P+E +RK ++ Sbjct: 322 STVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQE--TYRKIMNF 378 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFV-ADP--AKRISIPEIRNHEWF 277 +Q+ PD +HIS E LI R+ AD + EI++H +F Sbjct: 379 EQTLQF--PDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFF 424 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 70/148 (47%), Gaps = 6/148 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPN 76 + VK IG G FG RL++ K + ++ A+K + + E ++ + R + P Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPW 163 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V +L ++ME+ GG+L + F+ED RF+ + I + H + Sbjct: 164 VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGF 223 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYS 164 HR +K +N L+D +K+ DFG S Sbjct: 224 IHRAIKPDNILID--IRGHIKLSDFGLS 249 >2PMN-X nrPDB Length = 348 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 49/171 (28%), Positives = 79/171 (46%), Gaps = 19/171 (11%) Query: 122 QQLISGVSYCHAMQ-VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 + +++ SY H + +CHRD+K N L+D + R+K+ DFG S+ V + K + GT Sbjct: 158 KSVLNSFSYIHNEKNICHRDVKPSNILMDKNG--RVKLSDFGESEYMV-DKKIKGSRGTY 214 Query: 181 AYIAPEVLLKKE-YDGKVADVWSCGVTLYVMLVGAYPFEDP----EEPKNFR-KTIHRIL 234 ++ PE + Y+G D+WS G+ LYVM PF E N R K I L Sbjct: 215 EFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPL 274 Query: 235 NVQYAIPDYVHISPECRH---------LISRIFVADPAKRISIPEIRNHEW 276 + + + + C + + +PA+RI+ + HEW Sbjct: 275 DRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEW 325 >4IAN-A nrPDB Length = 358 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 91/207 (43%), Gaps = 12/207 (5%) Query: 20 RYELVKDIGSGNF-GVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN-- 76 RY + G G F V R + ++N+ VAVK I E + + +E+ + L + Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 77 ----IVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSY 130 +R HL +V E S E+ ++ R + QQL + Sbjct: 91 DKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKL 150 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 + H D+K +N L++ S LK+CDFG S S V + + + Y APE+++ Sbjct: 151 LKRCNILHADIKPDNILVNESKTI-LKLCDFG-SASHVADNDITPYLVSRFYRAPEIIIG 208 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPF 217 K YD + D+WS G TLY + G F Sbjct: 209 KSYDYGI-DMWSVGCTLYELYTGKILF 234 >2XYN-A nrPDB Length = 292 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/252 (25%), Positives = 103/252 (40%), Gaps = 19/252 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +G G +G + K+ + VAVK ++ E +E + ++HPN+V+ V Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTL 99 Query: 87 PTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 IV EY G L + R CN + + Q+ S + Y HRDL Sbjct: 100 EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 159 Query: 145 NTLLDGSPAPRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 N L+ + +K+ DFG S+ + H+ K + + APE L + K +D Sbjct: 160 NCLVGENHV--VKVADFGLSRLMTGDTYTAHAGAKFPI---KWTAPESLAYNTFSIK-SD 213 Query: 200 VWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIF 258 VW+ GV L+ + G P+ P ++ +L Y + P+ L+ + Sbjct: 214 VWAFGVLLWEIATYGMSPY-----PGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACW 268 Query: 259 VADPAKRISIPE 270 PA R S E Sbjct: 269 KWSPADRPSFAE 280 >2JD5-A nrPDB Length = 373 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 118/261 (45%), Gaps = 52/261 (19%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI------DE-----------NV 62 RY LV+ +G G+F L +D +N VA+K I RG+K+ DE N Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMK-IVRGDKVYTEAAEDEIKLLQRVNDADNT 78 Query: 63 KRE---------IINHRSLRHPNIVRFKEV--ILTPTHLAIVMEYASGGELFERICNAGR 111 K + +++H + + PN V V +L LA++ +Y G + + Sbjct: 79 KEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISK 138 Query: 112 FSEDEARFFFQQLISGVSYCHA-MQVCHRDLKLENTLLDGSPAP----RLKICDFGYSKS 166 QL+ G+ Y H + H D+K EN L++ +P ++KI D G + Sbjct: 139 -----------QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG--NA 185 Query: 167 SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 +++ T Y +PEVLL + G AD+WS ++ ++ G + FE P+E ++ Sbjct: 186 CWYDEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFE-PDEGHSY 243 Query: 227 RKT---IHRILNVQYAIPDYV 244 K I +I+ + +P Y+ Sbjct: 244 TKDDDHIAQIIELLGELPSYL 264 >2OZO-A nrPDB Length = 613 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 100/213 (46%), Gaps = 22/213 (10%) Query: 26 DIGSGNFGVAR----LMRDKQSNELVAVKYIERG-EKID-ENVKREIINHRSLRHPNIVR 79 ++G GNFG R MR KQ + VA+K +++G EK D E + RE L +P IVR Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCHAMQV 136 V L +VME A GG L + + G+ E Q+ G+ Y Sbjct: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLKKE 192 HR+L N LL KI DFG SK+ + +S P + APE + ++ Sbjct: 458 VHRNLAARNVLLVNRHY--AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 Query: 193 YDGKVADVWSCGVTLYVML-VGAYPFEDPEEPK 224 + + +DVWS GVT++ L G P++ + P+ Sbjct: 516 FSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPE 547 >5H2U-A nrPDB Length = 267 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 67/263 (25%), Positives = 111/263 (42%), Gaps = 22/263 (8%) Query: 19 DRYELVKDIGSGNFG--VARLMRDKQSNELVAVKYIERGEKIDEN-VKREIINHRSLRHP 75 + + L + +GSG FG L +D+ VA+K I R + + ++ EI + LRH Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQ---VAIKVISRDNLLHQQMLQSEIQAMKKLRHK 62 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHA 133 +I+ V+ + I+ E + G L E R + E Q+ G+ Y + Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYIAPEVLLK 190 HRDL N L+ + K+ DFG + K V S + + APE L + Sbjct: 123 QNYIHRDLAARNILVGENTL--CKVGDFGLARLIKEDVYLSHDHNI--PYKWTAPEALSR 178 Query: 191 KEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Y K +DVWS G+ L+ M G P+ + F + ++ Y +P + P Sbjct: 179 GHYSTK-SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR-----VDAGYRMPCPLECPPS 232 Query: 250 CRHLISRIFVADPAKRISIPEIR 272 L+ + DP +R + +R Sbjct: 233 VHKLMLTCWCRDPEQRPTFKALR 255 >6HV0-A nrPDB Length = 416 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 99/224 (44%), Gaps = 33/224 (14%) Query: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELFER--ICNAGRFSEDEARFFFQQLISGVS 129 HPN++R+ E ++AI + A+ E E+ + G E QQ SG++ Sbjct: 61 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLQQTTSGLA 116 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAP---RLKICDFGYSKSSVL----HSQPKSTVGTPAY 182 + H++ + HRDLK N L+ A + I DFG K + S+ GT + Sbjct: 117 HLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 176 Query: 183 IAPEVLLK--KEYDGKVADVWSCG-VTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 IAPE+L + KE D++S G V YV+ G++PF K++ R N+ Sbjct: 177 IAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFG---------KSLQRQANILLG 227 Query: 240 IPDYVHISPE------CRHLISRIFVADPAKRISIPEIRNHEWF 277 + PE R LI ++ DP KR S + H +F Sbjct: 228 ACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5VC6-A nrPDB Length = 289 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 122/297 (41%), Gaps = 39/297 (13%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKR 64 G + + ++ +EL K IGSG FG + + A+K ++ G ++N R Sbjct: 1 GAGSMKSRYTTEFHELEK-IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALR 59 Query: 65 EIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARF 119 E+ H L +H ++VR+ H+ I EY +GG L + I R F E E + Sbjct: 60 EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPR-----------------LKICDFG 162 Q+ G+ Y H+M + H D+K N + + P KI D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 163 YSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE 222 + S P+ G ++A EVL + AD+++ +T+ V GA P Sbjct: 180 HVTRI---SSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPL----- 230 Query: 223 PKNFRKTIHRILNVQY-AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 P+N + H I + IP +S E L+ + DP +R S + H L Sbjct: 231 PRNGDQW-HEIRQGRLPRIPQV--LSQEFTELLKVMIHPDPERRPSAMALVKHSVLL 284 >5IKW-A nrPDB Length = 310 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 114/280 (40%), Gaps = 43/280 (15%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV-KREIINHRSLR-HPNIVRF 80 L + + G F L+R A+K + D NV KREI + L H NIV + Sbjct: 18 LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 76 Query: 81 KEVILTPT-----HLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHA 133 + + + I+MEY G++ ++ + F+E E F V+ H Sbjct: 77 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 136 Query: 134 MQ--VCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTPA 181 + + HRDLK+EN LL DG +CDFG + + L+ Q T + Sbjct: 137 CKTPIIHRDLKVENILLNDGG---NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 182 YIAPEVLLKKEYDGK----VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 Y APE++ Y GK AD+W+ G LY + PF + + I + Sbjct: 194 YRAPEMI--NLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA---------ICDGN 242 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 + IPD S LI + DP R P+I +F Sbjct: 243 FTIPDNSRYSRNIHCLIRFMLEPDPEHR---PDIFQVSYF 279 >5XVU-A nrPDB Length = 332 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/293 (21%), Positives = 130/293 (44%), Gaps = 39/293 (13%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 +RYE++K IG G + D + N A+K ++ +K + +I+ + + PNI+ Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLN-GGPNII 89 Query: 79 RFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 + +++ P +++ EY + + F+ + +F++ + R++ Q++ + YCH+ + Sbjct: 90 KLLDIVKDPVTKTPSLIFEYINNID-FKTL--YPKFTDKDIRYYIYQILKALDYCHSQGI 146 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRD+K N ++D ++++ +G ++ + V + Y PE+L+ + Sbjct: 147 MHRDVKPHNIMIDHENR-QIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYDY 205 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ--------YAI---PDYVH 245 D+WS G L M+ PF + + I ++L + Y I P Y++ Sbjct: 206 SLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLN 265 Query: 246 ISPECRH---------------------LISRIFVADPAKRISIPEIRNHEWF 277 I E LI ++ + D AKRI+ E H +F Sbjct: 266 ILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYF 318 >5MJB-A nrPDB Length = 305 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 96/209 (45%), Gaps = 22/209 (10%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR----HPNIVR 79 IG+G FG RL + VA+K ++ G E +R+ ++ S+ H NI+R Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG--YSEKQRRDFLSEASIMGQFDHRNIIR 91 Query: 80 FKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + V+ + I+ E+ L F R N G+F+ + + + +G+ Y M Sbjct: 92 LEGVVTKSRPVMIITEFMENCALDSFLR-QNDGQFTVIQLVGMLRGIAAGMKYLSEMNYV 150 Query: 138 HRDLKLENTLLDGSPAPRLKICDFG---YSKSSVLHSQPKSTVGTPA---YIAPEVLLKK 191 HRDL N L++ + K+ DFG Y + S++G + APE + + Sbjct: 151 HRDLAARNILVNSNLV--CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYR 208 Query: 192 EYDGKVADVWSCGVTLY-VMLVGAYPFED 219 ++ +DVWS G+ ++ VM G P+ D Sbjct: 209 KFT-SASDVWSYGIVMWEVMSFGERPYWD 236 >6EII-A nrPDB Length = 352 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 6/145 (4%) Query: 75 PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 PNI+ +++ P A+V E+ + + F+++ ++ + RF+ +++ + YCH Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCH 171 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 +M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 172 SMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 230 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPF 217 D+WS G L M+ PF Sbjct: 231 MYDYSLDMWSLGCMLASMIFRKEPF 255 >3A4O-X nrPDB Length = 286 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 95/202 (47%), Gaps = 11/202 (5%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 +LVK +G+G FG + S + VAVK ++ G + E ++L+H +VR Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 74 Query: 82 EVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 V+ + I+ EY + G L F + G+ + F Q+ G++Y HR Sbjct: 75 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 134 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEYDGK 196 DL+ N L+ S + KI DFG ++ + ++ + G + APE + + K Sbjct: 135 DLRAANVLV--SESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 191 Query: 197 VADVWSCGVTLY-VMLVGAYPF 217 +DVWS G+ LY ++ G P+ Sbjct: 192 -SDVWSFGILLYEIVTYGKIPY 212 >5UNP-A nrPDB Length = 369 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 96/226 (42%), Gaps = 28/226 (12%) Query: 18 SDRYELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREI-----INHRS 71 +RYE+V +G G FG V + + ++ VA+K I+ EK E + EI IN + Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKD 92 Query: 72 LRHPNI-VRFKEVILTPTHLAIVMEYASGGEL-FERICNAGRFSEDEARFFFQQLISGVS 129 + N+ V+ + H+ I E F + N + + R QL V Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVK 152 Query: 130 YCHAMQVCHRDLKLENTLLDGS-----------------PAPRLKICDFGYSKSSVLHSQ 172 + H ++ H DLK EN L S + +++ DFG ++ H Sbjct: 153 FLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG--SATFDHEH 210 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 + V T Y APEV+L+ + + DVWS G ++ VG F+ Sbjct: 211 HSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQ 255 >5WNO-A nrPDB Length = 330 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 111/256 (43%), Gaps = 22/256 (8%) Query: 22 ELVKDIGSGNFGV--ARLMRDKQSNEL---VAVKYIERGEKIDENVKREIINHRSLRHPN 76 +L K +G+G FG A + K++ + VA+K + + + + E N LRH N Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDN 84 Query: 77 IVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 +++ + L IV Y G L F ++ + E + Q+ SG+ Y Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKL-HKENLGAREQVLYCYQIASGMQYLEKQ 143 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP----AYIAPEVLLK 190 +V HRDL N L+ ++I DFG SK + H T+ + ++A E+ K Sbjct: 144 RVVHRDLATRNVLV--KKFNHVEITDFGLSK-ILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 191 KEYDGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Y +DVW+ GVT + ++ G P++ +IH L + + S + Sbjct: 201 HCYT-HASDVWAFGVTCWEIITFGQSPYQGMST-----DSIHNFLKDGNRLSQPPNCSQD 254 Query: 250 CRHLISRIFVADPAKR 265 + R ++ADP R Sbjct: 255 LYQELLRCWMADPKSR 270 >4MD7-E nrPDB Length = 391 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 102/204 (50%), Gaps = 9/204 (4%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-P 75 + D Y+LV+ +G G + + +NE V VK ++ +K + +I+ +LR P Sbjct: 35 NQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE--NLRGGP 92 Query: 76 NIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 NI+ +++ P A+V E+ + + F+++ ++ + RF+ +++ + YCH+ Sbjct: 93 NIITLADIVKDPVSRTPALVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ + Sbjct: 150 MGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 Query: 194 DGKVADVWSCGVTLYVMLVGAYPF 217 D+WS G L M+ PF Sbjct: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 >5VD3-A nrPDB Length = 311 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 117/266 (43%), Gaps = 27/266 (10%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSL-RHPN 76 ++ + +G G++G +R K+ L AVK RG K E+ +H + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF--FFQQLISGVSYCHAM 134 VR ++ L + E G ++ C A S EA+ + + + +++ H+ Sbjct: 119 CVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + H D+K N L P R K+ DFG + G P Y+APE LL+ Y Sbjct: 177 GLVHLDVKPANIFL--GPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPE-LLQGSY- 232 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY-VHISPECRHL 253 G ADV+S G+T+ + A E P + +++ L Y P++ +S E R + Sbjct: 233 GTAADVFSLGLTILEV---ACNMELPHGGEGWQQ-----LRQGYLPPEFTAGLSSELRSV 284 Query: 254 ISRIFVADPAKR------ISIPEIRN 273 + + DP R +++P +R Sbjct: 285 LVMMLEPDPKLRATAEALLALPVLRQ 310 >2RIO-A nrPDB Length = 434 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 101/236 (42%), Gaps = 36/236 (15%) Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF--------FFQQLI 125 HPN++R+ T L I +E + + + + S++ + +Q+ Sbjct: 68 HPNVIRYYCSETTDRFLYIALELCNLN--LQDLVESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 126 SGVSYCHAMQVCHRDLKLENTLLD-----------GSPAPRLKICDFGYSKS-----SVL 169 SGV++ H++++ HRDLK +N L+ G+ R+ I DFG K S Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 170 HSQPKSTVGTPAYIAPEV------LLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDP-E 221 + + GT + APE+ L K + D++S G Y +L G +PF D Sbjct: 186 RTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYS 245 Query: 222 EPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 N + I L+ + D I+ E LIS++ DP KR + ++ H F Sbjct: 246 RESNIIRGIFS-LDEMKCLHDRSLIA-EATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >6NPU-A nrPDB Length = 298 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 19/253 (7%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +G G +G K+ + VAVK ++ E +E + ++HPN+V+ V Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 93 Query: 87 PTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 I+ E+ + G L + R CN + + Q+ S + Y HRDL Sbjct: 94 EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 153 Query: 145 NTLLDGSPAPRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 N L+ + +K+ DFG S+ + H+ K + + APE L ++ K +D Sbjct: 154 NCLVGENHL--VKVADFGLSRLMTGDTYTAHAGAKFPI---KWTAPESLAYNKFSIK-SD 207 Query: 200 VWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIF 258 VW+ GV L+ + G P+ P ++ +L Y + + L+ + Sbjct: 208 VWAFGVLLWEIATYGMSPY-----PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 262 Query: 259 VADPAKRISIPEI 271 +P+ R S EI Sbjct: 263 QWNPSDRPSFAEI 275 >5FM2-A nrPDB Length = 355 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/283 (26%), Positives = 117/283 (41%), Gaps = 53/283 (18%) Query: 23 LVKDIGSGNFG-----VARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHP 75 L K +G G FG A ++ + VAVK ++ E ++ E + + HP Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 127 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELF-----ERICNAGRFSE------------DEAR 118 ++++ L +++EYA G L R G DE Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 119 F-------FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK------ 165 F Q+ G+ Y M++ HRDL N L+ + ++KI DFG S+ Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV--AEGRKMKISDFGLSRDVYEED 245 Query: 166 SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEE 222 S V SQ + V ++A E L Y + +DVWS GV L+ ++ +G YP PE Sbjct: 246 SYVKRSQGRIPV---KWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGNPYPGIPPER 301 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 N KT HR+ PD + S E L+ + + +P KR Sbjct: 302 LFNLLKTGHRMER-----PD--NCSEEMYRLMLQCWKQEPDKR 337 >6CTH-A nrPDB Length = 309 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/188 (31%), Positives = 82/188 (43%), Gaps = 12/188 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHPNIVRFKEVI 84 +G G FG + S+ +AVK + R K I E I R LRH N+V+ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISR-LRHKNLVKLIGWC 81 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARF-FFQQLISGVSYCHAMQ---VCHRD 140 L +V E+ + G L I E R+ + L S + Y H V HRD Sbjct: 82 HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLHRD 141 Query: 141 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPEVLLKKEYDGKVA 198 +K N +LD S +L DFG ++ K T+ GT Y+APE L + K + Sbjct: 142 IKTSNIMLDSSFNAKLG--DFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKAS-KES 198 Query: 199 DVWSCGVT 206 DV+S GV Sbjct: 199 DVYSFGVV 206 >4M7I-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 92/227 (40%), Gaps = 36/227 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPNIV 78 +E ++ +G G FGV ++K + A+K I E E V RE+ L HP IV Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 66 Query: 79 RFKEVILTP------------THLAIVMEYASGGELFERICNAGRFSEDEARF---FFQQ 123 R+ L +L I M+ L + + E E F Q Sbjct: 67 RYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQ 126 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGY--------SKSSVLHSQP-- 173 + V + H+ + HRDLK N +K+ DFG + +VL P Sbjct: 127 IAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 174 ---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 VGT Y++PE + Y KV D++S G+ L+ +L YPF Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNSYSHKV-DIFSLGLILFELL---YPF 227 >3PP0-A nrPDB Length = 338 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 101/208 (48%), Gaps = 19/208 (9%) Query: 24 VKDIGSGNFGVAR---LMRDKQSNEL-VAVKYIERGEKIDENVKREIINHR----SLRHP 75 VK +GSG FG + D ++ ++ VA+K + E +EI++ + P Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR--ENTSPKANKEILDEAYVMAGVGSP 79 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAM 134 + R + LT T + +V + G L + + N GR + + Q+ G+SY + Sbjct: 80 YVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV 138 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA---YIAPEVLLKK 191 ++ HRDL N L+ SP +KI DFG ++ + G ++A E +L++ Sbjct: 139 RLVHRDLAARNVLVK-SPN-HVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRR 196 Query: 192 EYDGKVADVWSCGVTLY-VMLVGAYPFE 218 + + +DVWS GVT++ +M GA P++ Sbjct: 197 RFTHQ-SDVWSYGVTVWELMTFGAKPYD 223 >4AT3-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 29/235 (12%) Query: 8 GPMDLPIMHDSDRYELV--KDIGSGNFGVARL-----MRDKQSNELVAVKYIE-RGEKID 59 G MD + H R+ +V +++G G FG L + +Q LVAVK ++ + Sbjct: 1 GAMDTFVQH-IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR 59 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--------- 110 ++ RE +L+H +IV+F V + L +V EY G+L + + G Sbjct: 60 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEG 119 Query: 111 ----RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK- 165 ++ + QQ+ +G+ Y + HRDL N L+ + +KI DFG S+ Sbjct: 120 NPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL--VKIGDFGMSRD 177 Query: 166 --SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 S+ + T+ ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 178 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE-SDVWSLGVVLWEIFTYGKQPW 231 >4XEY-B nrPDB Length = 408 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 64/283 (22%), Positives = 116/283 (40%), Gaps = 26/283 (9%) Query: 4 PAVSGPMDLPIMHDSDRYELVK-------DIGSGNFGVARLMRDKQSNELVAVKYIERGE 56 P + P + + D++E+ + +G G +G K+ + VAVK ++ Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 162 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSE 114 E +E + ++HPN+V+ V I+ E+ + G L + R CN + Sbjct: 163 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNA 222 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-----SSVL 169 + Q+ S + Y HRDL N L+ + +K+ DFG S+ + Sbjct: 223 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYTA 280 Query: 170 HSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRK 228 H+ K + + APE L ++ K +DVW+ GV L+ + G P+ P Sbjct: 281 HAGAKFPI---KWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPY-----PGIDLS 331 Query: 229 TIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 ++ +L Y + + L+ + +P+ R S EI Sbjct: 332 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 374 >6HMD-A nrPDB Length = 365 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 133/301 (44%), Gaps = 41/301 (13%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRS 71 +P + D Y+LV+ +G G + + +NE V VK ++ +K + +I+ + Sbjct: 46 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILE--N 103 Query: 72 LRH-PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 LR NI++ + + P A+V EY + + F+++ ++ + RF+ +L+ + Sbjct: 104 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKAL 160 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 YCH+ + HRD+K N ++D +L++ D+G ++ + V + + PE+L Sbjct: 161 DYCHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 219 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPF---ED-------------PEEPKNFRKTIHR 232 + + D+WS G L M+ PF +D EE + K H Sbjct: 220 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 279 Query: 233 ILNVQY----------AIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHEW 276 L+ + +++H +SPE L+ ++ D +R++ E H + Sbjct: 280 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 339 Query: 277 F 277 F Sbjct: 340 F 340 >4NEU-A nrPDB Length = 333 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 26/225 (11%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRS 71 M SD E ++ SG FG L + L+ +K + +G +E + E Sbjct: 21 MKSSDFLESA-ELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMNR 78 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 LRH +V+ VI+ ++VMEY G L + ++I G+ Y Sbjct: 79 LRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYL 138 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFG---YSKSSVLHSQ-----------PKSTV 177 H V H+DLK EN L+D +KI D G + S L+++ K Sbjct: 139 HGKGVIHKDLKPENILVDND--FHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 178 GTPAYIAPEVLLKKEYDGK---VADVWSCGVTLYVMLVGAYPFED 219 GT Y+APE L + + K +DV+S V L+ + P+E+ Sbjct: 197 GTLYYMAPEHL--NDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN 239 >4M66-A nrPDB Length = 325 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 94/207 (45%), Gaps = 32/207 (15%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +G G FGV + N VAVK + +KI VK + +LR+ N++ +L Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIV-NSKKISWEVKAMV----NLRNENVL-----LLL 77 Query: 87 PTHLAIVMEYASGGELFERICN----AGRFSEDEARFF------FQQLISGVSYCHAMQ- 135 + ++ SG L R AG + R + Q+++ G+ Y H++ Sbjct: 78 GVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDP 137 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSK-------SSVLHSQPKSTVGTPAYIAPEV 187 + HRDLK N LLD P K+ DFG S S S + + GT AY+ PE+ Sbjct: 138 PLLHRDLKPSNILLD--PELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPEL 195 Query: 188 LLKKEYDG-KVADVWSCGVTLYVMLVG 213 L K K +DV+S G+ ++ +L G Sbjct: 196 LFKVNLKASKASDVYSFGILVWAVLAG 222 >2FO0-A nrPDB Length = 495 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 63/283 (22%), Positives = 116/283 (40%), Gaps = 26/283 (9%) Query: 4 PAVSGPMDLPIMHDSDRYELVK-------DIGSGNFGVARLMRDKQSNELVAVKYIERGE 56 P + P + + D++E+ + +G G +G K+ + VAVK ++ Sbjct: 195 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 254 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSE 114 E +E + ++HPN+V+ V I+ E+ + G L + R CN + Sbjct: 255 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNA 314 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-----SSVL 169 + Q+ S + Y HR+L N L+ + +K+ DFG S+ + Sbjct: 315 VVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHL--VKVADFGLSRLMTGDTYTA 372 Query: 170 HSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRK 228 H+ K + + APE L ++ K +DVW+ GV L+ + G P+ P Sbjct: 373 HAGAKFPI---KWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPY-----PGIDLS 423 Query: 229 TIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 ++ +L Y + + L+ + +P+ R S EI Sbjct: 424 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 466 >2A1A-B nrPDB Length = 284 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 90/203 (44%), Gaps = 24/203 (11%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF------ 80 IGSG FG + + + +K ++ +E +RE+ L H NIV + Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIKRVKYN---NEKAEREVKALAKLDHVNIVHYNGCWDG 75 Query: 81 ---------KEVILTPTH-LAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISGV 128 K + T L I ME+ G L + I + + A F+Q+ GV Sbjct: 76 FDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV 135 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H+ ++ +RDLK N L ++KI DFG S + + GT Y++PE + Sbjct: 136 DYIHSKKLINRDLKPSNIFL--VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI 193 Query: 189 LKKEYDGKVADVWSCGVTLYVML 211 ++Y GK D+++ G+ L +L Sbjct: 194 SSQDY-GKEVDLYALGLILAELL 215 >4XCU-A nrPDB Length = 300 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 74/287 (25%), Positives = 121/287 (42%), Gaps = 35/287 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFG-VARL-------MRDKQSNELVAVKYIE---RGEK 57 P+D DR L K +G G FG V R R Q++ VAVK ++ + Sbjct: 7 PLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAST-VAVKMLKDNASDKD 65 Query: 58 IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEA 117 + + V + RH NI+ V L +++E A+ G L E + E Sbjct: 66 LADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 118 RFFFQQLIS-------GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS--SV 168 F L+S G+ Y + + HRDL N L+ +KI DFG ++ + Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--MKIADFGLARGVHHI 183 Query: 169 LHSQPKSTVGTPA-YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPK 224 + + S P ++APE L + Y + +DVWS G+ L+ + +G YP EE Sbjct: 184 DYYKKTSNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGILLWEIFTLGGSPYPGIPVEELF 242 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + + HR+ + P+ + EC H A P++R + ++ Sbjct: 243 SLLREGHRMDRPPHCPPELYGLMRECWH-------AAPSQRPTFKQL 282 >4PL5-B nrPDB Length = 435 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 31/223 (13%) Query: 74 HPNIVRF--KEVILTPTHLAIVMEYASGGELFER--ICNAGRFSEDEARFFFQQLISGVS 129 HPN++R+ E ++AI + A+ E E+ + G E Q SG++ Sbjct: 80 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLHQTTSGLA 135 Query: 130 YCHAMQVCHRDLKLENTLLDGSPA-PRLK--ICDFGYSKSSVL----HSQPKSTVGTPAY 182 + H++ + HRDLK N LL A R+K I DFG K + S+ GT + Sbjct: 136 HLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 195 Query: 183 IAPEVLLK--KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 IAPE+L + K+ D++S G Y ++ Y F K++ R N+ Sbjct: 196 IAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGY--------HPFGKSLQRQANILLGA 247 Query: 241 P--DYVHISPE----CRHLISRIFVADPAKRISIPEIRNHEWF 277 D H R LI ++ DP +R S + H +F Sbjct: 248 CNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >1AD5-A nrPDB Length = 438 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/258 (24%), Positives = 111/258 (43%), Gaps = 27/258 (10%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 +L K +G+G FG M + VAVK ++ G E E ++L+H +V+ Sbjct: 185 KLEKKLGAGQFGEV-WMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 243 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF--FFQQLISGVSYCHAMQVCHR 139 V+ T + I+ E+ + G L + + + + + F Q+ G+++ HR Sbjct: 244 AVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 302 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEYDGK 196 DL+ N L+ S KI DFG ++ VG + APE + + K Sbjct: 303 DLRAANILVSASLV--CKIADFGLAR-----------VGAKFPIKWTAPEAINFGSFTIK 349 Query: 197 VADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 +DVWS G+ L ++ G P+ P+ + R L Y +P + E +++ Sbjct: 350 -SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCPEELYNIMM 403 Query: 256 RIFVADPAKRISIPEIRN 273 R + P +R + I++ Sbjct: 404 RCWKNRPEERPTFEYIQS 421 >3RAW-A nrPDB Length = 381 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 77/330 (23%), Positives = 123/330 (37%), Gaps = 68/330 (20%) Query: 19 DRYELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 +RYE+V ++G G FG V + + VA+K I K E + EI + ++ + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 78 V-RFKEVILT-----PTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISGVS 129 +F V+++ H+ I E G FE + N + R QL + Sbjct: 111 ENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRL-----------------KICDFGYSKSSVLHSQ 172 + H Q+ H DLK EN L S L ++ DFG ++ H Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG--SATFDHEH 227 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF------ 226 + V T Y PEV+L+ + + DVWS G L+ G F+ E ++ Sbjct: 228 HTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKI 286 Query: 227 -----RKTIHRILNVQYAI----------PDYVHISPECR-----------------HLI 254 IHR +Y D ++ C+ L+ Sbjct: 287 LGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLM 346 Query: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPAD 284 R+ DPA+RI++ E H +F P + Sbjct: 347 RRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >3LLT-A nrPDB Length = 360 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 105/236 (44%), Gaps = 38/236 (16%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE------RGEKIDENVKREIINHRS 71 ++ + +++ +G G FG L + + + AVK + R KI+ ++ ++I + Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKI-QNDD 92 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVS 129 + + NIV++ + H+ ++ E G L+E I N F ++ + + +++ ++ Sbjct: 93 INNNNIVKYHGKFMYYDHMCLIFE-PLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALN 151 Query: 130 YCHAMQVCHRDLKLENTLLDG-----------------------SPAPRLKICDFGYSK- 165 Y M + H DLK EN LLD + + +K+ DFG + Sbjct: 152 YLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF 211 Query: 166 SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE 221 S H S + T Y APEV+L +D +D+WS G L + G+ F E Sbjct: 212 KSDYHG---SIINTRQYRAPEVILNLGWDVS-SDMWSFGCVLAELYTGSLLFRTHE 263 >2DQ7-X nrPDB Length = 283 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 94/205 (45%), Gaps = 18/205 (8%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 +L+K +G+G FG M N VA+K ++ G E+ E + L+H +V+ Sbjct: 12 QLIKRLGNGQFGEV-WMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 70 Query: 82 EVILTPTHLAIVMEYASGGELFERICNA-GRFSE-----DEARFFFQQLISGVSYCHAMQ 135 V+ + + IV EY + G L + + + GR + D A Q+ +G++Y M Sbjct: 71 AVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA----AQVAAGMAYIERMN 125 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 HRDL+ N L+ KI DFG ++ ++ + + APE L + Sbjct: 126 YIHRDLRSANILVGNGLI--CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 183 Query: 194 DGKVADVWSCGVTLYVMLV-GAYPF 217 K +DVWS G+ L ++ G P+ Sbjct: 184 TIK-SDVWSFGILLTELVTKGRVPY 207 >2PSQ-A nrPDB Length = 370 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 110/252 (43%), Gaps = 39/252 (15%) Query: 2 DRPAVSG------PMDLPIMHDSDRYELVKDIGSGNFGVARLM------RDKQSNEL-VA 48 D P ++G P D D+ L K +G G FG + +DK + VA Sbjct: 58 DTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVA 117 Query: 49 VKYI--ERGEKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFER 105 VK + + EK ++ E+ + + +H NI+ L +++EYAS G L E Sbjct: 118 VKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREY 177 Query: 106 I-----------CNAGRFSEDEARF-----FFQQLISGVSYCHAMQVCHRDLKLENTLLD 149 + + R E++ F QL G+ Y + + HRDL N L+ Sbjct: 178 LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 237 Query: 150 GSPAPRLKICDFGYSKS-SVLHSQPKSTVGT--PAYIAPEVLLKKEYDGKVADVWSCGVT 206 + +KI DFG ++ + + K+T G ++APE L + Y + +DVWS GV Sbjct: 238 ENNV--MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVL 294 Query: 207 LY-VMLVGAYPF 217 ++ + +G P+ Sbjct: 295 MWEIFTLGGSPY 306 >4K33-A nrPDB Length = 325 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/285 (24%), Positives = 118/285 (41%), Gaps = 44/285 (15%) Query: 20 RYELVKDIGSGNFGVARLM------RDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 R L K +G G FG + +D+ + + + + + D+++ + ++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 96 Query: 74 ----HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-----FSED-----EARF 119 H NI+ L +++EYA+ G L E A R +S D E + Sbjct: 97 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLRE-FLRARRPPGLDYSFDTSKPPEEQL 155 Query: 120 FFQQLIS-------GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHS 171 F+ L+S G+ Y + + HRDL N L+ +KI DFG ++ L Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV--MKIADFGLARDVHNLDY 213 Query: 172 QPKSTVGT--PAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFED--PEEPKNF 226 ++T G ++APE L + Y + +DVWS GV L+ + +G P+ EE Sbjct: 214 YKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 272 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 K HR+ D I EC H A P++R + ++ Sbjct: 273 LKEGHRMDKPANCTHDLYMIMRECWH-------AAPSQRPTFKQL 310 >4WUA-A nrPDB Length = 401 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 101/261 (38%), Gaps = 66/261 (25%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH--PN- 76 RY +++ +G G+F L D Q + VA+K ++ E E EI +S+R+ PN Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 77 -----IVR----FKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 +V+ FK + TH+ +V E G L + I N + QQ++ Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKIIQQVL 160 Query: 126 SGVSYCHA-MQVCHRDLKLENTLL-------------------DGSPAP----------- 154 G+ Y H ++ H D+K EN LL G+P P Sbjct: 161 QGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPAT 220 Query: 155 -----------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 ++KI D G + +H + T Y + EVL+ Y+ Sbjct: 221 AGNFLVNPLEPKNAEKLKVKIADLG--NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTP- 277 Query: 198 ADVWSCGVTLYVMLVGAYPFE 218 AD+WS + + G Y FE Sbjct: 278 ADIWSTACMAFELATGDYLFE 298 >5KMM-A nrPDB Length = 329 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 28/220 (12%) Query: 23 LVKDIGSGNFGVARL-----MRDKQSNELVAVKYI-ERGEKIDENVKREIINHRSLRHPN 76 L ++G G FG L + +Q LVAVK + E E ++ +RE L+H + Sbjct: 39 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 98 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAG------RFSEDEA---------RFFF 121 IVRF V L +V EY G+L + + G ED A Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVG 178 Q+ +G+ Y + HRDL N L+ +KI DFG S+ S+ + T+ Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLV--VKIGDFGMSRDIYSTDYYRVGGRTML 216 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 ++ PE +L +++ + +DVWS GV L+ + G P+ Sbjct: 217 PIRWMPPESILYRKFTTE-SDVWSFGVVLWEIFTYGKQPW 255 >5U6B-A nrPDB Length = 307 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 128/301 (42%), Gaps = 50/301 (16%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL--VAVKYIE-----RGEKIDENVKREI 66 +M D + L K +G G FG + Q + + VAVK ++ R E E+ E Sbjct: 18 VMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSEL--EDFLSEA 75 Query: 67 INHRSLRHPNIVRFKEVILTPTHL------AIVMEYASGGEL-----FERICNAGRFSED 115 + + HPN++R V + +++ + G+L + R+ + + Sbjct: 76 VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT 135 Query: 116 EARF-FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHS 171 + F + SG+ Y + HRDL N +L+ + + + + DFG SK + + Sbjct: 136 QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS--VCVADFGLSKKIYNGDYYR 193 Query: 172 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA---YPFEDPEEPKNFRK 228 Q + +IA E L + Y K +DVWS GVT++ + YP + E ++ + Sbjct: 194 QGRIAKMPVKWIAIESLADRVYTSK-SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 252 Query: 229 TIHRI------LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIR-NHEWFLKNL 281 +R+ L+ YA L+SR + +P R S E+R + E LK L Sbjct: 253 QGNRLKQPADCLDGLYA-------------LMSRCWELNPQDRPSFTELREDLENTLKAL 299 Query: 282 P 282 P Sbjct: 300 P 300 >3UIU-A nrPDB Length = 306 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 90/216 (41%), Gaps = 37/216 (17%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF------ 80 IGSG FG + + + ++ ++ +E +RE+ L H NIV + Sbjct: 20 IGSGGFGQVFKAKHRIDGKTYVIRRVKYN---NEKAEREVKALAKLDHVNIVHYNGCWDG 76 Query: 81 ----------------------KEVILTPTH-LAIVMEYASGGELFERI--CNAGRFSED 115 K + T L I ME+ G L + I + + Sbjct: 77 FDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV 136 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 175 A F+Q+ GV Y H+ ++ HRDLK N L ++KI DFG S + Sbjct: 137 LALELFEQITKGVDYIHSKKLIHRDLKPSNIFL--VDTKQVKIGDFGLVTSLKNDGKRTR 194 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 + GT Y++PE + ++Y GK D+++ G+ L +L Sbjct: 195 SKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELL 229 >6FER-A nrPDB Length = 309 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 95/215 (44%), Gaps = 38/215 (17%) Query: 27 IGSGNFGVARL--------MRDK------QSNE--LVAVKYI--ERGEKIDENVKREIIN 68 +G G FG L +DK +N+ LVAVK + + + + +EI Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 76 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI----------CNAGRFSEDEAR 118 L+ PNI+ V +T L ++ EY G+L + + + S + Sbjct: 77 MSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLK 136 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 F Q+ SG+ Y ++ HRDL N L+ + +KI DFG S++ L+S + Sbjct: 137 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYT--IKIADFGMSRN--LYSGDYYRIQ 192 Query: 179 TPA-----YIAPEVLLKKEYDGKVADVWSCGVTLY 208 A +++ E +L ++ +DVW+ GVTL+ Sbjct: 193 GRAVLPIRWMSWESILLGKFT-TASDVWAFGVTLW 226 >5E8V-A nrPDB Length = 316 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 95/225 (42%), Gaps = 32/225 (14%) Query: 15 MHDSDRY--ELVKDIGSGNFGVARLMRDKQSN----ELVAVKYIERGEKIDENVKREIIN 68 MH+++ EL +G G F + KQ+ E VAVK E +++I + Sbjct: 3 MHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 62 Query: 69 HRSLRHPNIVRFKEVILTPTHLA----IVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 +L+H NI++F T L ++ + + G L E + S ++ R L Sbjct: 63 DINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL-TRHVISWEDLRKLGSSL 121 Query: 125 ISGVSYCHA---------MQVCHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLH 170 G+++ H+ M + HRDLK N L+ L CDFG S SV Sbjct: 122 ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL--CDFGLSLRLDPTLSVDD 179 Query: 171 SQPKSTVGTPAYIAPEVL-----LKKEYDGKVADVWSCGVTLYVM 210 VGT Y+APEVL L+ K DV+S + L+ M Sbjct: 180 LANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >2HK5-A nrPDB Length = 270 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 17/258 (6%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 +L K +G+G FG M + VAVK ++ G E E ++L+H +V+ Sbjct: 18 KLEKKLGAGQFGEV-WMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 76 Query: 82 EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF--FFQQLISGVSYCHAMQVCHR 139 V+ T + I+ E+ + G L + + + + + F Q+ G+++ HR Sbjct: 77 AVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 135 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEYDGK 196 DL+ N L+ S KI DFG ++ + ++ + G + APE + + K Sbjct: 136 DLRAANILVSASLV--CKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIK 192 Query: 197 VADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 +DVWS G+ L ++ G P+ P+ + R L Y +P + E +++ Sbjct: 193 -SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCPEELYNIMM 246 Query: 256 RIFVADPAKRISIPEIRN 273 R + P +R + I++ Sbjct: 247 RCWKNRPEERPTFEYIQS 264 >1PY5-A nrPDB Length = 326 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 87/208 (41%), Gaps = 27/208 (12%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF-- 80 L + IG G FG + R K E VAVK E+ + EI LRH NI+ F Sbjct: 33 LQESIGKGRFG--EVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 81 --KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM---- 134 + T T L +V +Y G LF+ + E + SG+++ H Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALST-ASGLAHLHMEIVGT 149 Query: 135 ----QVCHRDLKLENTLLDGSPAPRLKICDFGY-----SKSSVLHSQPKSTVGTPAYIAP 185 + HRDLK +N L+ + I D G S + + P VGT Y+AP Sbjct: 150 QGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 186 EVL-----LKKEYDGKVADVWSCGVTLY 208 EVL +K K AD+++ G+ + Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFW 235 >3REP-A nrPDB Length = 271 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 97/234 (41%), Gaps = 20/234 (8%) Query: 42 QSNELVA--VKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPT--HLAIVMEYA 97 Q N++V +K + + + E R HPN++ +P H ++ + Sbjct: 32 QGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWM 91 Query: 98 SGGELFERICNAGRFSEDEARF--FFQQLISGVSYCHAMQ--VCHRDLKLENTLLDGSPA 153 G L+ + F D+++ F + G+++ H ++ + L + ++D Sbjct: 92 PYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMT 151 Query: 154 PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG--KVADVWSCGVTLYVML 211 R+ + D +S Q + PA++APE L KK D + AD+WS V L+ ++ Sbjct: 152 ARISMADVKFS------FQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELV 205 Query: 212 VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 PF D + K + ++ IP ISP L+ DPAKR Sbjct: 206 TREVPFADLSNMEIGMKVA--LEGLRPTIPP--GISPHVSKLMKICMNEDPAKR 255 >6FEX-A nrPDB Length = 321 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 99/237 (41%), Gaps = 45/237 (18%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVK------------- 63 R + +G G FG L +LV++ + + +G + VK Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARND 76 Query: 64 --REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR--- 118 +E+ L+ PNI+R V + L ++ +Y G+L + +A + + A Sbjct: 77 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL-NQFLSAHQLEDKAAEGAP 135 Query: 119 -----------FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 Q+ SG+ Y + HRDL N L+ + +KI DFG S++ Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT--IKIADFGMSRN- 192 Query: 168 VLHSQPKSTVGTPA-----YIAPEVLLKKEYDGKVADVWSCGVTLY--VMLVGAYPF 217 L++ V A ++A E +L ++ +DVW+ GVTL+ +ML A PF Sbjct: 193 -LYAGDYYRVQGRAVLPIRWMAWECILMGKFT-TASDVWAFGVTLWEVLMLCRAQPF 247 >3BBT-B nrPDB Length = 328 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 99/206 (48%), Gaps = 15/206 (7%) Query: 24 VKDIGSGNFGVAR---LMRDKQSNEL-VAVKYIER--GEKIDENVKREIINHRSLRHPNI 77 VK +GSG FG + + ++ ++ VA+K + G K + E + S+ HP++ Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 79 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAMQV 136 VR V L+PT + +V + G L E + + + Q+ G+ Y ++ Sbjct: 80 VRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRL 138 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEY 193 HRDL N L+ SP +KI DFG ++ + + G ++A E + +++ Sbjct: 139 VHRDLAARNVLVK-SPN-HVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 196 Query: 194 DGKVADVWSCGVTLY-VMLVGAYPFE 218 + +DVWS GVT++ +M G P++ Sbjct: 197 THQ-SDVWSYGVTIWELMTFGGKPYD 221 >3Q4U-A nrPDB Length = 301 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 93/211 (44%), Gaps = 33/211 (15%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 L++ +G G +G + R E VAVK ++ + E+ N LRH NI+ F Sbjct: 12 LLECVGKGRYG--EVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA 69 Query: 83 VILTPTH----LAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM---- 134 +T H L ++ Y G L++ + + R + SG+++ H Sbjct: 70 SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL-SIASGLAHLHIEIFGT 128 Query: 135 ----QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--------VGTPAY 182 + HRDLK +N L+ + + I D G +V+HSQ + VGT Y Sbjct: 129 QGKPAIAHRDLKSKNILVKKN--GQCCIADLGL---AVMHSQSTNQLDVGNNPRVGTKRY 183 Query: 183 IAPEVLLKK----EYDG-KVADVWSCGVTLY 208 +APEVL + +D K D+W+ G+ L+ Sbjct: 184 MAPEVLDETIQVDCFDSYKRVDIWAFGLVLW 214 >2X7G-A nrPDB Length = 389 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/291 (22%), Positives = 110/291 (37%), Gaps = 68/291 (23%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH----- 74 RY +++ +G G+F L D Q VA+K ++ + E EI + +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 75 PN-------IVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 PN I FK + H+ +V E G L + I N + +Q++ Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVL 150 Query: 126 SGVSYCHA-MQVCHRDLKLENTLL-------------------DGSPAP----------- 154 G+ Y H+ ++ H D+K EN L+ G+P P Sbjct: 151 QGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAA 210 Query: 155 ---------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 R+KI D G + +H + T Y + EVL+ Y AD Sbjct: 211 DLLVNPLDPRNADKIRVKIADLG--NACWVHKHFTEDIQTRQYRSIEVLIGAGYSTP-AD 267 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKT---IHRILNVQYAIPDYVHIS 247 +WS + + G Y FE P +++ + I I+ + +IP + +S Sbjct: 268 IWSTACMAFELATGDYLFE-PHSGEDYSRDEDHIAHIIELLGSIPRHFALS 317 >1LUF-A nrPDB Length = 343 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 92/221 (41%), Gaps = 37/221 (16%) Query: 22 ELVKDIGSGNFGVARLMRDK-----QSNELVAVKYI--ERGEKIDENVKREIINHRSLRH 74 E V+DIG G FG R + +VAVK + E + + +RE + Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 109 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFE----------------------RICNAG-- 110 PNIV+ V + ++ EY + G+L E R+ + G Sbjct: 110 PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPP 169 Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS--SV 168 S E +Q+ +G++Y + HRDL N L+ + +KI DFG S++ S Sbjct: 170 PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV--VKIADFGLSRNIYSA 227 Query: 169 LHSQPKSTVGTPA-YIAPEVLLKKEYDGKVADVWSCGVTLY 208 + + P ++ PE + Y + +DVW+ GV L+ Sbjct: 228 DYYKADGNDAIPIRWMPPESIFYNRYTTE-SDVWAYGVVLW 267 >5SYS-A nrPDB Length = 286 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 67/268 (25%), Positives = 110/268 (41%), Gaps = 39/268 (14%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 I +S R E+ +G G FG M VA+K ++ G E +E + LR Sbjct: 15 IPRESLRLEV--KLGQGCFGEC-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 71 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---------QL 124 H +V+ V+ + + IV EY S G L + F + E + + Q+ Sbjct: 72 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLD-------FLKGEMGKYLRLPQLVDMAAQI 123 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 182 SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + + Sbjct: 124 ASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKW 181 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 APE L + K +DVWS G+ L + G P+ P + + + Y +P Sbjct: 182 TAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMP 235 Query: 242 DYVHISPEC----RHLISRIFVADPAKR 265 PEC L+ + + DP +R Sbjct: 236 ----CPPECPESLHDLMCQCWRKDPEER 259 >3PG1-A nrPDB Length = 362 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/277 (23%), Positives = 106/277 (38%), Gaps = 46/277 (16%) Query: 60 ENVKREI--INHRSLRHPNI-------VRFKEVILTPTHLAIVMEYASGGELF--ERICN 108 + V REI +NH HPNI V F+E + +L + ++ +RI Sbjct: 74 KRVLREIRLLNH--FHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIV- 130 Query: 109 AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 168 S ++F ++ G+ H V HRDL N LL + + ICDF ++ Sbjct: 131 ---ISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILL--ADNNDITICDFNLAREDT 185 Query: 169 LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRK 228 + V Y APE++++ + K+ D+WS G + M F K Sbjct: 186 ADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNK 245 Query: 229 TIHRILN------VQYAIP---DYVHIS-----------------PECRHLISRIFVADP 262 + + V ++ P DY+ S P LI+++ +P Sbjct: 246 IVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNP 305 Query: 263 AKRISIPEIRNHEWFLKNL-PADLMNDNTMTTQFDES 298 +RIS + H +F P DL + FDES Sbjct: 306 QRRISTEQALRHPYFESLFDPLDLTEGLSERFHFDES 342 >3LMG-A nrPDB Length = 344 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 104/209 (49%), Gaps = 23/209 (11%) Query: 24 VKDIGSGNFGVAR---LMRDKQSNEL-VAVKYIE--RGEKIDENVKREIINHRSLRHPNI 77 +K +GSG FG + + +S ++ V +K IE G + + V ++ SL H +I Sbjct: 36 LKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHI 95 Query: 78 VRFKEVILTP-THLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 VR + L P + L +V +Y G L + + + G + Q+ G+ Y Sbjct: 96 VRL--LGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSK------SSVLHSQPKSTVGTPAYIAPEVLL 189 + HR+L N LL SP+ ++++ DFG + +L+S+ K+ + ++A E + Sbjct: 154 MVHRNLAARNVLLK-SPS-QVQVADFGVADLLPPDDKQLLYSEAKTPI---KWMALESIH 208 Query: 190 KKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 +Y + +DVWS GVT++ +M GA P+ Sbjct: 209 FGKYTHQ-SDVWSYGVTVWELMTFGAEPY 236 >5AR8-A nrPDB Length = 326 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 89/217 (41%), Gaps = 19/217 (8%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEV 83 ++ + G G R VAVK++ + ++ +++++ + H + Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 84 IL----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---QLISGVSYCHAMQ- 135 IL P L IV EY G L E + + + F+ ++ GV+Y H M Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVL 188 + H DLK +N LLD +KI DFG SK ++ + GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNE--FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 189 L--KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEP 223 +K D++S V + +L PFED P Sbjct: 215 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP 251 >2C47-A nrPDB Length = 313 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH------ 74 + + K IG GNFG RL ++ +NE VA+K E I + + +R + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLSATEG 61 Query: 75 -PNIVRFKEVILTPTHLAIVMEY--ASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 P + F + A+V+E S +LF+ +C+ F+ QLI+ + Y Sbjct: 62 VPQVYYFGPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFTLKTVLMIAIQLITRMEYV 116 Query: 132 HAMQVCHRDLKLENTLLDGSPAPR----LKICDFGY--------SKSSVLHSQPKSTVGT 179 H + +RD+K EN L+ G P + + I DFG +K + + + KS GT Sbjct: 117 HTKSLIYRDVKPENFLV-GRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 175 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 Y++ L KE + D+ + G L G+ P++ Sbjct: 176 ARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 213 >5EG3-A nrPDB Length = 334 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 114/268 (42%), Gaps = 35/268 (13%) Query: 19 DRYELVKDIGSGNFGVARLM------RDKQSNEL-VAVKYI--ERGEKIDENVKREIINH 69 D+ L K +G G FG + +DK + VAVK + + EK ++ E+ Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 94 Query: 70 RSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERI-----------CNAGRFSEDEA 117 + + +H NI+ L +++ YAS G L E + + R E++ Sbjct: 95 KMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQM 154 Query: 118 RF-----FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLH 170 F QL G+ Y + + HRDL N L+ + +KI DFG ++ +++ Sbjct: 155 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV--MKIADFGLARDINNIDF 212 Query: 171 SQPKSTVGTPA-YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPKNF 226 + + P ++APE L + Y + +DVWS GV ++ + +G YP EE Sbjct: 213 FKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMWEIFTLGGSPYPGIPVEELFKL 271 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLI 254 K HR+ + + +C H + Sbjct: 272 LKEGHRMDKPANCTNELYMMMRDCWHAV 299 >2QKW-B nrPDB Length = 321 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/88 (43%), Positives = 47/88 (53%), Gaps = 6/88 (6%) Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTV--GTPAYI 183 G+ Y H + HRD+K N LLD + P KI DFG SK L STV GT YI Sbjct: 151 GLHYLHTRAIIHRDVKSINILLDENFVP--KITDFGISKKGTELDQTHLSTVVKGTLGYI 208 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVML 211 PE +K K +DV+S GV L+ +L Sbjct: 209 DPEYFIKGRLTEK-SDVYSFGVVLFEVL 235 >2PL0-A nrPDB Length = 289 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 98/215 (45%), Gaps = 13/215 (6%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 +LV+ +G+G FG M + VAVK +++G + E + L+H +VR Sbjct: 26 KLVERLGAGQFGEV-WMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY 84 Query: 82 EVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 V+ T + I+ EY G L F + + + + ++ Q+ G+++ HR Sbjct: 85 AVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 143 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 DL+ N L+ + + KI DFG ++ ++ + + APE + + K Sbjct: 144 DLRAANILVSDTLS--CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK- 200 Query: 198 ADVWSCGVTLYVMLV-GAYPF---EDPEEPKNFRK 228 +DVWS G+ L ++ G P+ +PE +N + Sbjct: 201 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER 235 >3MDY-A nrPDB Length = 337 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 95/213 (44%), Gaps = 27/213 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 + + ++VK IG G +G + K E VAVK E+ + EI +RH NI Sbjct: 36 AKQIQMVKQIGKGRYG--EVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENI 93 Query: 78 VRFKEVIL----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 + F + + T L ++ +Y G L++ + + ++ + + +SG+ + H Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSS-VSGLCHLHT 152 Query: 134 M--------QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTP 180 + HRDLK +N L+ + I D G + + + P + VGT Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 181 AYIAPEVL---LKKEYDGK--VADVWSCGVTLY 208 Y+ PEVL L + + +AD++S G+ L+ Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILW 243 >2PVN-A nrPDB Length = 352 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 76/149 (51%), Gaps = 14/149 (9%) Query: 75 PNIVRFKEVIL-----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 PNIV+ +++ TP+ ++ EY + + F+ + ++ + R++ +L+ + Sbjct: 107 PNIVKLLDIVRDQHSKTPS---LIFEYVNNTD-FKVLYPT--LTDYDIRYYIYELLKALD 160 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 YCH+ + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 161 YCHSQGIMHRDVKPHNVMID-HELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLV 219 Query: 190 K-KEYDGKVADVWSCGVTLYVMLVGAYPF 217 ++YD + D+WS G M+ PF Sbjct: 220 DLQDYDYSL-DMWSLGCMFAGMIFRKEPF 247 >5HLW-A nrPDB Length = 299 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 101/232 (43%), Gaps = 23/232 (9%) Query: 27 IGSGNFGV---ARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIVRFK 81 IG G+FG L+ + AVK + R I E E I + HPN++ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 82 EVIL-TPTHLAIVMEYASGGELFERICNAGRF-SEDEARFFFQQLISGVSYCHAMQVCHR 139 + L + +V+ Y G+L I N + + F Q+ G+ Y + + HR Sbjct: 88 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR 147 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-------YIAPEVLLKKE 192 DL N +LD +K+ DFG ++ +H + +V ++A E L ++ Sbjct: 148 DLAARNCMLDEKFT--VKVADFGLARD--MHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 193 YDGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 + K +DVWS GV L+ +M GA P+ D F T++ + + P+Y Sbjct: 204 FTTK-SDVWSFGVLLWELMTRGAPPYPDVN---TFDITVYLLQGRRLLQPEY 251 >5OAT-A nrPDB Length = 411 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/159 (28%), Positives = 73/159 (45%), Gaps = 21/159 (13%) Query: 127 GVSYCHAMQVCHRDLKLENTLLDGS--PAPRLKICDFGYSKSSVLH--SQPKSTV----- 177 GV++ A + HRDLK +N LLD S +P L I DFG + + S P ++ Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 178 GTPAYIAPEVLLKKEYDGKV-----ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 G A +APE++ +K V AD+W+ G Y + PF P KNF Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGD 284 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + + +P + + L++ + +P KR+ PE+ Sbjct: 285 LPKLPDEVPTVI------QALVANLLKRNPNKRLD-PEV 316 >4NT4-A nrPDB Length = 312 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 97/217 (44%), Gaps = 22/217 (10%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-----IDENVKREIINHRSLRHP 75 + + K IG GNFG RL ++ +NE VA+K K ++ + + +H Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPD 73 Query: 76 NIVRFKEV-ILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 I R + + A+V+E S +LF IC A +FS +QL+ + Y H Sbjct: 74 GIPRIYHLGTCGGRYNAMVLELLGLSLEDLFN-IC-ARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLK---ICDFGYSKS--------SVLHSQPKSTVGTPA 181 + + +RD+K EN L+ + R K I DFG +K + + + KS GT Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTAR 191 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 Y++ + +E + D+ + G L G+ P++ Sbjct: 192 YMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQ 227 >5LPZ-A nrPDB Length = 332 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 85/209 (40%), Gaps = 13/209 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 IGSG FG K + + K I + D E+ ++H N+V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 87 PTHLAIVMEYASGGELFERICN---AG-RFSEDEARFFFQQLISGVSYCH---AMQVCHR 139 +V E+ G L + + + AG + + R G+++ H + + HR Sbjct: 85 GDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHR 144 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 D+K N LLD + R + DFG ++ + H + GTP Y+ PE K Sbjct: 145 DMKSSNVLLDENLEAR--VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 202 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKN 225 DV+S GV L +L G P + P+ N Sbjct: 203 -GDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5TOS-A nrPDB Length = 395 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 87/206 (42%), Gaps = 22/206 (10%) Query: 27 IGSGNFGV--------ARLMRDKQSNELV-AVKYI-ERGEKIDENVKREIINHRSLRHPN 76 IG G FG + L K LV AVK + + G + EI L HPN Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL----ISGVSYCH 132 +V+ L H +V E+ G L + G + + F + G+++ H Sbjct: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 Query: 133 A--MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV---LHSQPKSTVGTPAYIAPEV 187 + ++V +RD+K N LLD K+ DFG ++ L +GT Y APE Sbjct: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVG 213 + + + +DV+S GV L +L G Sbjct: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 >4F9B-A nrPDB Length = 361 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/174 (28%), Positives = 69/174 (39%), Gaps = 39/174 (22%) Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N++ K H+ I M Y E F I N+ F E R + L + H Sbjct: 81 NVMGVKYCFRKNDHVVIAMPYLEH-ESFLDILNSLSF--QEVREYMLNLFKALKRIHQFG 137 Query: 136 VCHRDLKLENTLLDGSPAPRLK---ICDFGYSKSS------VLH-----------SQPKS 175 + HRD+K N L + RLK + DFG ++ + +L SQ K Sbjct: 138 IVHRDVKPSNFLYN----RRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKC 193 Query: 176 TV------------GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 ++ GTP + APEVL K D+WS GV +L G YPF Sbjct: 194 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 247 >2H34-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 87/204 (42%), Gaps = 9/204 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPN 76 Y L + +G G G D +VA+K + D ++RE L+ P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V + L + M +G +L + G + A +Q+ S + HA Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEVLLKKEYD 194 HRD+K EN L+ L DFG + ++ +Q +TVGT Y+APE + + Sbjct: 156 THRDVKPENILVSADDFAYL--VDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFSESHA 212 Query: 195 GKVADVWSCGVTLYVMLVGAYPFE 218 AD+++ LY L G+ P++ Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQ 236 >5LPV-A nrPDB Length = 296 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 85/209 (40%), Gaps = 13/209 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 IGSG FG K + + K I + D E+ ++H N+V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 87 PTHLAIVMEYASGGELFERICN---AG-RFSEDEARFFFQQLISGVSYCH---AMQVCHR 139 +V E+ G L + + + AG + + R G+++ H + + HR Sbjct: 85 GDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHR 144 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 D+K N LLD + R + DFG ++ + H + GTP Y+ PE K Sbjct: 145 DMKSSNVLLDENLEAR--VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 202 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKN 225 DV+S GV L +L G P + P+ N Sbjct: 203 -GDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >6FYV-A nrPDB Length = 337 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 97/242 (40%), Gaps = 33/242 (13%) Query: 20 RYELVKDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREI--INHRSLRHPN 76 RYE+V +G G FG V + VAVK ++ + E + EI + H + PN Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 77 ----IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 V+ E H+ IV E G ++ I F D R Q+ +++ Sbjct: 75 SVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQSINF 133 Query: 131 CHAMQVCHRDLKLENTLLDGS-----------------PAPRLKICDFGYSKSSVLHSQP 173 H ++ H DLK EN L S +K+ DFG S+ + Sbjct: 134 LHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG---SATYDDEH 190 Query: 174 KST-VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 ST V T Y APEV+L + + DVWS G L +G F+ + K + R Sbjct: 191 HSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQ-THDSKEHLAMMER 248 Query: 233 IL 234 IL Sbjct: 249 IL 250 >2H8H-A nrPDB Length = 535 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 25/205 (12%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 I +S R E+ +G G FG M VA+K ++ G E +E + LR Sbjct: 264 IPRESLRLEV--KLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 320 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---------QL 124 H +V+ V+ + + IV EY S G L + F + E + + Q+ Sbjct: 321 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAAQI 372 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 182 SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + + Sbjct: 373 ASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKW 430 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTL 207 APE L + K +DVWS G+ L Sbjct: 431 TAPEAALYGRFTIK-SDVWSFGILL 454 >3SV0-A nrPDB Length = 483 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 96/225 (42%), Gaps = 42/225 (18%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 +++ L + IGSG+FG L + Q+NE VA+K ENVK +HP ++ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL--------ENVK--------TKHPQLL 50 Query: 79 ---RFKEVILTPTHLAIVMEYASGGEL-----------FERICN--AGRFSEDEARFFFQ 122 + ++ T + V + G+ E + N + + S Sbjct: 51 YESKIYRILQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLAD 110 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQP 173 Q+I+ V + H+ HRD+K +N L+ G A ++ I DFG +K + + + Sbjct: 111 QMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYREN 170 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 K+ GT Y + L E + D+ S G L L G+ P++ Sbjct: 171 KNLTGTARYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQ 214 >2CHL-A nrPDB Length = 351 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH------ 74 + + K IG GNFG RL ++ +NE VA+K E + + + +R + Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDG 87 Query: 75 -PNIVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 P + F + A+V+E S +LF+ +C+ FS QLIS + Y Sbjct: 88 IPQVYYFGPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFSLKTVLMIAIQLISRMEYV 142 Query: 132 HAMQVCHRDLKLENTLLDGSPAPR----LKICDFGY--------SKSSVLHSQPKSTVGT 179 H+ + +RD+K EN L+ G P + + I DF +K + + + KS GT Sbjct: 143 HSKNLIYRDVKPENFLI-GRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGT 201 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 Y++ L KE + D+ + G L G+ P++ Sbjct: 202 ARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 239 >6BSD-A nrPDB Length = 876 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 59/242 (24%), Positives = 98/242 (40%), Gaps = 49/242 (20%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVK------------- 63 R + +G G FG L +LV++ + + +G + VK Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARND 631 Query: 64 --REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGEL--------FERICNAGRFS 113 +E+ L+ PNI+R V + L ++ +Y G+L E G Sbjct: 632 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPG 691 Query: 114 EDEAR-----------FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 + +A Q+ SG+ Y + HRDL N L+ + +KI DFG Sbjct: 692 DGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT--IKIADFG 749 Query: 163 YSKSSVLHSQPKSTVGTPA-----YIAPEVLLKKEYDGKVADVWSCGVTLY--VMLVGAY 215 S++ L++ V A ++A E +L ++ +DVW+ GVTL+ +ML A Sbjct: 750 MSRN--LYAGDYYRVQGRAVLPIRWMAWECILMGKFT-TASDVWAFGVTLWEVLMLCRAQ 806 Query: 216 PF 217 PF Sbjct: 807 PF 808 >3GQL-A nrPDB Length = 326 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 111/269 (41%), Gaps = 37/269 (13%) Query: 19 DRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIER--GEKIDENVKREIINH 69 DR L K +G G FG L +DK + VAVK ++ EK ++ E+ Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 87 Query: 70 RSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------------- 111 + + +H NI+ L +++EYAS G L E + A R Sbjct: 88 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYCYNPSHNPEEQ 146 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 170 S + Q+ G+ Y + + HRDL N L+ +KI DFG ++ + Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLARDIHHID 204 Query: 171 SQPKSTVGT--PAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPKN 225 K+T G ++APE L + Y + +DVWS GV L+ + +G YP EE Sbjct: 205 YYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 263 Query: 226 FRKTIHRILNVQYAIPDYVHISPECRHLI 254 K HR+ + + +C H + Sbjct: 264 LLKEGHRMDKPSNCTNELYMMMRDCWHAV 292 >3C1X-A nrPDB Length = 373 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 106/245 (43%), Gaps = 26/245 (10%) Query: 27 IGSGNFGV---ARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIVRFK 81 IG G+FG L+ + AVK + R I E E I + HPN++ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 82 EVIL-TPTHLAIVMEYASGGELFERICNAGRF-SEDEARFFFQQLISGVSYCHAMQVCHR 139 + L + +V+ Y G+L I N + + F Q+ G+ + + + HR Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHR 216 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSV------LHSQPKSTVGTPAYIAPEVLLKKEY 193 DL N +LD +K+ DFG ++ +H++ + + ++A E L +++ Sbjct: 217 DLAARNCMLDEKFT--VKVADFGLARDMYDKEFDSVHNKTGAKLPV-KWMALESLQTQKF 273 Query: 194 DGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIH-----RILNVQYAIPDYVHIS 247 K +DVWS GV L+ +M GA P+ D F T++ R+L +Y + Sbjct: 274 TTK-SDVWSFGVLLWELMTRGAPPYPDVN---TFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 248 PECRH 252 +C H Sbjct: 330 LKCWH 334 >6F3F-A nrPDB Length = 455 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 88/205 (42%), Gaps = 25/205 (12%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 I +S R E+ +G G FG M VA+K ++ G E +E + LR Sbjct: 184 IPRESLRLEV--KLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 240 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---------QL 124 H +V+ V+ + + IV EY + G L + F + E + + Q+ Sbjct: 241 HEKLVQLYAVV-SEEPIYIVTEYMNKGSLLD-------FLKGETGKYLRLPQLVDMSAQI 292 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 182 SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + + Sbjct: 293 ASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKW 350 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTL 207 APE L + K +DVWS G+ L Sbjct: 351 TAPEAALYGRFTIK-SDVWSFGILL 374 >3TT0-A nrPDB Length = 382 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 111/269 (41%), Gaps = 37/269 (13%) Query: 19 DRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIER--GEKIDENVKREIINH 69 DR L K +G G FG L +DK + VAVK ++ EK ++ E+ Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 128 Query: 70 RSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------------- 111 + + +H NI+ L +++EYAS G L E + A R Sbjct: 129 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYSYNPSHNPEEQ 187 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 170 S + Q+ G+ Y + + HRDL N L+ +KI DFG ++ + Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLARDIHHID 245 Query: 171 SQPKSTVGT--PAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPKN 225 K+T G ++APE L + Y + +DVWS GV L+ + +G YP EE Sbjct: 246 YYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 304 Query: 226 FRKTIHRILNVQYAIPDYVHISPECRHLI 254 K HR+ + + +C H + Sbjct: 305 LLKEGHRMDKPSNCTNELYMMMRDCWHAV 333 >3V5Q-A nrPDB Length = 297 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 29/221 (13%) Query: 23 LVKDIGSGNFGVARL-----MRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPN 76 L +++G G FG L + + LVAVK ++ ++ +RE +L+H + Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 78 Query: 77 IVRFKEVILTPTHLAIVMEYASGGEL--FERICN--------------AGRFSEDEARFF 120 IV+F V L +V EY G+L F R G + Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTV 177 Q+ SG+ Y + HRDL N L+ + +KI DFG S+ S+ + T+ Sbjct: 139 ASQIASGMVYLASQHFVHRDLATRNCLVGANLL--VKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 197 LPIRWMPPESIMYRKFTTE-SDVWSFGVILWEIFTYGKQPW 236 >5A46-A nrPDB Length = 386 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 111/269 (41%), Gaps = 37/269 (13%) Query: 19 DRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIER--GEKIDENVKREIINH 69 DR L K +G G FG L +DK + VAVK ++ EK ++ E+ Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 99 Query: 70 RSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------------- 111 + + +H NI+ L +++EYAS G L E + A R Sbjct: 100 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYCYNPSHNPEEQ 158 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 170 S + Q+ G+ Y + + HRDL N L+ +KI DFG ++ + Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLARDIHHID 216 Query: 171 SQPKSTVGT--PAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGA--YPFEDPEEPKN 225 K+T G ++APE L + Y + +DVWS GV L+ + +G YP EE Sbjct: 217 YYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYPGVPVEELFK 275 Query: 226 FRKTIHRILNVQYAIPDYVHISPECRHLI 254 K HR+ + + +C H + Sbjct: 276 LLKEGHRMDKPSNCTNELYMMMRDCWHAV 304 >1FVR-A nrPDB Length = 327 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 90/217 (41%), Gaps = 33/217 (15%) Query: 27 IGSGNFG---VARLMRDKQSNELVAVK----YIERGEKIDENVKREIINHRSLRHPNIVR 79 IG GNFG AR+ +D + A+K Y + + D + E++ HPNI+ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMD-AAIKRMKEYASKDDHRDFAGELEVLCKLG-HHPNIIN 90 Query: 80 FKEVILTPTHLAIVMEYASGGELFERI----------------CNAGRFSEDEARFFFQQ 123 +L + +EYA G L + + A S + F Sbjct: 91 LLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAAD 150 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT--PA 181 + G+ Y Q HRDL N L+ + KI DFG S+ ++ K T+G Sbjct: 151 VARGMDYLSQKQFIHRDLAARNILVGENYVA--KIADFGLSRGQEVYV--KKTMGRLPVR 206 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 ++A E L Y +DVWS GV L+ ++ +G P+ Sbjct: 207 WMAIESLNYSVYTTN-SDVWSYGVLLWEIVSLGGTPY 242 >5GNK-A nrPDB Length = 297 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 106/222 (47%), Gaps = 24/222 (10%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVAR--LMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 L I+ +++ ++ +K +GSG FG L + + V E E +EI++ Sbjct: 13 LRILKETE-FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDE 71 Query: 70 R----SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE--ARFFFQ- 122 S+ +P++ R + LT T + ++M+ G L + + R +D +++ Sbjct: 72 AYVMASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYV----REHKDNIGSQYLLNW 126 Query: 123 --QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 Q+ G++Y ++ HRDL N L+ +P +KI DFG +K + G Sbjct: 127 CVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAEGGK 184 Query: 181 A---YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFE 218 ++A E +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 185 VPIKWMALESILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 225 >3QUP-A nrPDB Length = 323 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 67/282 (23%), Positives = 115/282 (40%), Gaps = 44/282 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQ---SNELVAVKYIERGEKIDENVK---REIINHRSLR 73 ++ L + +G G FG R + KQ S VAVK ++ +++ RE + Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 74 HPNIVRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLI-- 125 HP++ + V L +++ + G+L + A R E+ Q L+ Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLL-ASRIGENPFNLPLQTLVRF 142 Query: 126 -----SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC--DFGYSK---SSVLHSQPKS 175 G+ Y + HRDL N +L A + +C DFG S+ S + Q + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCML----AEDMTVCVADFGLSRKIYSGDYYRQGCA 198 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFEDPEEPKNFRKTIHRIL 234 + ++A E L Y +DVW+ GVT++ +M G P+ E + + I Sbjct: 199 SKLPVKWLALESLADNLYTVH-SDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG--- 254 Query: 235 NVQYAIPDYVHISPECRH----LISRIFVADPAKRISIPEIR 272 + + PEC L+ + + ADP +R S +R Sbjct: 255 ------GNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLR 290 >2CMW-A nrPDB Length = 310 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 94/215 (43%), Gaps = 31/215 (14%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH--------PN 76 K IG GNFG RL ++ +NE VA+K E I + + +R + P Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 77 IVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 + F + A+V+E S +LF+ +C+ F+ QL+S + Y H+ Sbjct: 62 VYYFGPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 135 QVCHRDLKLENTLLDGSPAPR---LKICDFGY--------SKSSVLHSQPKSTVGTPAYI 183 + +RD+K EN L+ + + I DFG +K + + + KS GT Y+ Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 + L KE + D+ + G L G+ P++ Sbjct: 177 SINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 210 >3ZBF-A nrPDB Length = 322 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 42/284 (14%) Query: 27 IGSGNFG-----VARLMRDKQSNEL-VAVKYIERGEKIDENVK--REIINHRSLRHPNIV 78 +GSG FG A + S E+ VAVK +++G E ++ +E HPNI+ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF------------FQQLIS 126 + V L I++E GG+L + A A F+ + Sbjct: 101 KQLGVCLLNEPQYIILELMEGGDLLTYLRKA-----RMATFYGPLLTLVDLVDLCVDISK 155 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGS--PAPRL-KICDFGYSK---SSVLHSQPKSTVGTP 180 G Y M HRDL N L+ +PR+ KI DFG ++ + + + + Sbjct: 156 GCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV 215 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA---YPFEDPEEPKNFRKTIHRILNVQ 237 ++APE L+ + + +DVWS G+ ++ +L YP + N+ +T R L Sbjct: 216 RWMAPESLMDGIFTTQ-SDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGR-LEPP 273 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 PD + +L+++ + +P +R + I++ +N Sbjct: 274 RNCPD------DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNF 311 >3MY0-A nrPDB Length = 305 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 91/216 (42%), Gaps = 43/216 (19%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 LV+ +G G +G + R E VAVK ++ + EI N LRH NI+ F Sbjct: 12 LVECVGKGRYG--EVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 83 VILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS---GVSYCHAM- 134 +T T L ++ Y G L++ + + E + +S G+++ H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFL----QRQTLEPHLALRLAVSAACGLAHLHVEI 125 Query: 135 -------QVCHRDLKLENTLLDGSPAPRLKIC--DFGYSKSSVLHSQPKS--------TV 177 + HRD K N L+ + L+ C D G +V+HSQ V Sbjct: 126 FGTQGKPAIAHRDFKSRNVLVKSN----LQCCIADLGL---AVMHSQGSDYLDIGNNPRV 178 Query: 178 GTPAYIAPEVLLKKEYDG-----KVADVWSCGVTLY 208 GT Y+APEVL ++ K D+W+ G+ L+ Sbjct: 179 GTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW 214 >5C26-A nrPDB Length = 299 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 81/194 (41%), Gaps = 15/194 (7%) Query: 25 KDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNIVR 79 K++GSGNFG V + + I + E D +K E++ + L +P IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 + + + +VME A G L + + + Q+ G+ Y HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 DL N LL KI DFG SK+ + +Q Y APE + ++ Sbjct: 152 DLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 208 Query: 195 GKVADVWSCGVTLY 208 K +DVWS GV ++ Sbjct: 209 SK-SDVWSFGVLMW 221 >5VDK-A nrPDB Length = 297 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 92/225 (40%), Gaps = 36/225 (16%) Query: 18 SDRYEL----VKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVK-REIINHR 70 + RYE V+ IG G FG + + A+K + E +EN E+ H Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 71 SL-RHPNIVRFKEVILTPTHLAIVMEYASGGEL----FERICNAGRFSEDEARFFFQQLI 125 L HP++VR+ H+ I EY +GG L E + F E + + Q+ Sbjct: 70 VLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 126 SGVSYCHAMQVCHRDLKLENTLL--------DG-------------SPAPRLKICDFGYS 164 G++Y H + H D+K N + G S KI D G++ Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 165 KSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYV 209 S ++PK G ++A E+L + AD+++ G+T+ V Sbjct: 190 TSI---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAV 231 >4FL3-A nrPDB Length = 635 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 81/194 (41%), Gaps = 15/194 (7%) Query: 25 KDIGSGNFG-VARLMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNIVR 79 K++GSGNFG V + + I + E D +K E++ + L +P IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 + + + +VME A G L + + + Q+ G+ Y HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 DL N LL KI DFG SK+ + +Q Y APE + ++ Sbjct: 494 DLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 550 Query: 195 GKVADVWSCGVTLY 208 K +DVWS GV ++ Sbjct: 551 SK-SDVWSFGVLMW 563 >3UIM-A nrPDB Length = 326 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 15/212 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHP 75 SD + +G G FG R LVAVK + ER + + + E+ H Sbjct: 29 SDNFSNKNILGRGGFGKVYKGRLADGT-LVAVKRLKEERTQGGELQFQTEVEMISMAVHR 87 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGE----LFERICNAGRFSEDEARFFFQQLISGVSYC 131 N++R + +TPT +V Y + G L ER + + + G++Y Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 132 HAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPE 186 H ++ HRD+K N LLD + DFG +K +T GT +IAPE Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEA--VVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPE 205 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 L + K DV+ GV L ++ G F+ Sbjct: 206 YLSTGKSSEKT-DVFGYGVMLLELITGQRAFD 236 >3LZB-A nrPDB Length = 327 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 105/222 (47%), Gaps = 24/222 (10%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVAR--LMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 L I+ +++ ++ +K +GSG FG L + + V E E +EI++ Sbjct: 9 LRILKETE-FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDE 67 Query: 70 R----SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE--ARFFFQ- 122 S+ +P++ R + LT T + ++ + G L + + R +D +++ Sbjct: 68 AYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYV----REHKDNIGSQYLLNW 122 Query: 123 --QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 Q+ G++Y ++ HRDL N L+ +P +KI DFG +K + G Sbjct: 123 CVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAEGGK 180 Query: 181 A---YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFE 218 ++A E +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 181 VPIKWMALESILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 221 >5M07-A nrPDB Length = 276 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/233 (21%), Positives = 89/233 (38%), Gaps = 33/233 (14%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRS----LRHPN 76 Y +V+ +G+ G L++ A+K + D+ +R L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE----DEARFFFQQLISGVSYCH 132 I+ + L I M+Y G + + + + RF E + + Y H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMAD--RFPAVLPVGEVLAIVTAVAGALDYAH 149 Query: 133 AMQVCHRDLKLENTLLDGSPA--PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 + HRD+ N +L A R+ + DFG + P+Y APE+ Sbjct: 150 QRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSAG 196 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFE-------DPEEPKNFRKTIHRILNV 236 + DG+ AD ++ +T + GA P + P + FR + R+ V Sbjct: 197 ADVDGR-ADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGV 248 >5XD6-A nrPDB Length = 305 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 91/221 (41%), Gaps = 29/221 (13%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 +D Y IG G++G +S + A+K ++ ++ D+ ++ LR N+ Sbjct: 21 TDNYGSKSLIGEGSYGRV-FYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENV 79 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR----FFFQQLIS------- 126 V + + EYA G L + + GR A+ + Q + Sbjct: 80 VALLGYCVDGPLRVLAYEYAPNGSLHDIL--HGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 127 GVSYCHAM---QVCHRDLKLENTLL-DGSPAPRLKICDFGYSK-----SSVLHSQPKSTV 177 G+ Y H V HRD+K N LL D A KI DF S ++ LHS + Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVA---KIADFDLSNQAPDMAARLHS--TRVL 192 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 GT Y APE + K +DV+S GV L +L G P + Sbjct: 193 GTFGYHAPEYAMTGTLSTK-SDVYSFGVVLLELLTGRKPVD 232 >3ZZW-A nrPDB Length = 289 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 87/199 (43%), Gaps = 27/199 (13%) Query: 42 QSNELVAVKYIERGEK--IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASG 99 + + VA+K ++ + + E + E + L+HPN+V V+ L+++ Y S Sbjct: 37 EQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSH 96 Query: 100 GELFE----RICNAGRFSEDEAR------------FFFQQLISGVSYCHAMQVCHRDLKL 143 G+L E R ++ S D+ R Q+ +G+ Y + V H+DL Sbjct: 97 GDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLAT 156 Query: 144 ENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA----YIAPEVLLKKEYDGKVAD 199 N L+ +KI D G + V + +G ++APE ++ ++ +D Sbjct: 157 RNVLV--YDKLNVKISDLGLFR-EVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSID-SD 212 Query: 200 VWSCGVTLY-VMLVGAYPF 217 +WS GV L+ V G P+ Sbjct: 213 IWSYGVVLWEVFSYGLQPY 231 >4TN6-A nrPDB Length = 318 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 100/236 (42%), Gaps = 17/236 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHP-N 76 +RY L + IGSG+FG L D + E VA+K +E + + E ++ ++ Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVG 64 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYCHAM 134 I + + +VME G E + N + +FS Q+IS + Y H+ Sbjct: 65 IPTIRWCGAEGDYNVMVMELL--GPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSK 122 Query: 135 QVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKSTVGTPAYIAP 185 HRD+K +N L+ G + I DFG +K + + + K+ GT Y + Sbjct: 123 NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 L E + D+ S G L +G+ P++ + R+ RI + + P Sbjct: 183 NTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAATK-RQKYERISEKKMSTP 236 >4BTK-A nrPDB Length = 337 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 101/232 (43%), Gaps = 19/232 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN-I 77 DR++++K IG G FG D + E VA+K +E ++ + +K E+ + L+ + + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 78 VRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 RF +VM+ G L R G F+ +Q++ + H++ Sbjct: 115 CRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVG 173 Query: 136 VCHRDLKLENTLLDGSPAPRLK--ICDFG----YSKSSVLHSQPKSTV---GTPAYIAPE 186 HRD+K N + P+ K + DFG Y+ ++ P++ GT Y + Sbjct: 174 FLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVN 233 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPF---EDPEEPKNFR-KTIHRIL 234 +E G+ D+WS L VG P+ +D E+ + K HR+L Sbjct: 234 AHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML 284 >4NFN-A nrPDB Length = 309 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 19/233 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN- 76 DR++++K IG G FG D + E VA+K +E ++ + +K E+ + L+ + Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDH 78 Query: 77 IVRFKEVILTPTHLAIVMEYASGGEL--FERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 + RF +VM+ G L R G F+ +Q++ + H++ Sbjct: 79 VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 137 Query: 135 QVCHRDLKLENTLLDGSPAPRLK--ICDFG----YSKSSVLHSQPKSTV---GTPAYIAP 185 HRD+K N + P+ K + DFG Y+ ++ P++ GT Y + Sbjct: 138 GFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASV 197 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF---EDPEEPKNFR-KTIHRIL 234 +E G+ D+WS L VG P+ +D E+ + K HR+L Sbjct: 198 NAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML 249 >4LRM-A nrPDB Length = 334 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 104/225 (46%), Gaps = 27/225 (12%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVAR--LMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 L I+ +++ ++ +K +GSG FG L + + V E E +EI++ Sbjct: 13 LRILKETE-FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDE 71 Query: 70 RSLR-------HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE--ARFF 120 + +P++ R + LT T + ++ + G L + + R +D +++ Sbjct: 72 AYVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYV----REHKDNIGSQYL 126 Query: 121 FQ---QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 Q+ G++Y ++ HRDL N L+ +P +KI DFG +K + Sbjct: 127 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAE 184 Query: 178 GTPA---YIAPEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFE 218 G ++A E +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 185 GGKVPIKWMALESILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 228 >5X1R-A nrPDB Length = 302 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 52/236 (22%), Positives = 94/236 (39%), Gaps = 38/236 (16%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK-YIE--------------RGE 56 LP + + +E+ + IG G FG+ D Q +A+K Y+ RGE Sbjct: 14 LPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGE 73 Query: 57 KIDENVKREI------------INHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFE 104 + + + + +H L H ++RF E T + ++ SG L Sbjct: 74 RFGKTFQAGLNSFIQEARLLARFSHPGLLH--VLRFWEENGTAY---MGTQFYSGTTLKN 128 Query: 105 -RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGY 163 + + E R L S ++ H HRD+ L+N + S P L DFG Sbjct: 129 LQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVL--LDFGS 186 Query: 164 SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVA---DVWSCGVTLYVMLVGAYP 216 ++ + + ++ + AP + DG+ D+++ G L+ ++VG+ P Sbjct: 187 ARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >5J0A-A nrPDB Length = 300 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 73/158 (46%), Gaps = 12/158 (7%) Query: 70 RSLRHPNIVRFKEVI-LTPTHLAIVMEYASGGELFERICNAGRFSED--EARFFFQ---Q 123 +SL HPNIV ++ L + MEY L + I + S+D A + Sbjct: 69 KSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALN 128 Query: 124 LISGVSYCHA-MQVCHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKST-VG 178 + G+ Y H ++ H D+K N ++ G +KICD G S ++ + P++ +G Sbjct: 129 MARGLKYLHQEKKLLHGDIKSSNVVIKGD-FETIKICDVGVSLPLDENMEVTDPEACYIG 187 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYP 216 T + E + + AD+++ G+TL+ M+ + P Sbjct: 188 TEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >1CSN-A nrPDB Length = 298 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 60/302 (19%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH----PN 76 Y++ + IG G+FGV + +N+ VA+K+ R + ++ E ++ L PN Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQ-LRDEYRTYKLLAGCTGIPN 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQ 135 + F + L H +V++ G L + + GR FS +Q+++ V H Sbjct: 71 VYYFGQEGL---HNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKS 126 Query: 136 VCHRDLKLENTLLDGSP----APRLKICDFGY--------SKSSVLHSQPKSTVGTPAYI 183 + +RD+K +N L+ G P A + + DFG +K + + + K+ GT Y+ Sbjct: 127 LVYRDIKPDNFLI-GRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE--------------------- 222 + L +E + D+ + G L G+ P++ + Sbjct: 186 SINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRE 244 Query: 223 -----PKNFRKTIHRILNVQY-AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEW 276 P+ F K +H N+ + A PDY ++ + L S++ +R++ E N +W Sbjct: 245 LCAGFPEEFYKYMHYARNLAFDATPDYDYL----QGLFSKVL-----ERLNTTEDENFDW 295 Query: 277 FL 278 L Sbjct: 296 NL 297 >2PZI-A nrPDB Length = 681 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 15/142 (10%) Query: 74 HPNIVR-FKEVILTPTHL----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP+IV+ F V T H IVMEY GG+ +R + EA + +++ + Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKR-SKGQKLPVAEAIAYLLEILPAL 195 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 SY H++ + + DLK EN +L +LK+ D G S ++S GTP + APE++ Sbjct: 196 SYLHSIGLVYNDLKPENIMLT---EEQLKLIDLG--AVSRINSF-GYLYGTPGFQAPEIV 249 Query: 189 LKKEYDGKVADVWSCGVTLYVM 210 + D+++ G TL + Sbjct: 250 --RTGPTVATDIYTVGRTLAAL 269 >5FQD-C nrPDB Length = 341 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 89/224 (39%), Gaps = 42/224 (18%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV- 78 +Y+LV+ IGSG+FG L + + E VAVK + + RHP ++ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK----------------LESQKARHPQLLY 63 Query: 79 --RFKEVILTPTHLAIVMEYASG-----------GELFERICN--AGRFSEDEARFFFQQ 123 + +++ + + Y G E + N + RF+ Q Sbjct: 64 ESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQ 123 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPK 174 +IS + Y H HRD+K +N L+ G +L + DFG +K + + + K Sbjct: 124 MISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDK 183 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 + GT Y + L E + D+ S G L + P++ Sbjct: 184 NLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQ 226 >2QLU-A nrPDB Length = 314 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 76/185 (41%), Gaps = 23/185 (12%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF- 80 +L++ G FG + + + N+ VAVK +K +REI + ++H N+++F Sbjct: 18 QLLEIKARGRFGC--VWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75 Query: 81 ---KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC------ 131 K L ++ + G L + + + +E + + G+SY Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVPW 134 Query: 132 -----HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAYI 183 H + HRD K +N LL L DFG + P T VGT Y+ Sbjct: 135 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVL--ADFGLAVRFEPGKPPGDTHGQVGTRRYM 192 Query: 184 APEVL 188 APEVL Sbjct: 193 APEVL 197 >4Y12-A nrPDB Length = 375 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 97/213 (45%), Gaps = 26/213 (12%) Query: 12 LPIMHDSD----RYELVKDIGSGNFGVARLMRDKQSN--ELVAVKYIERGEKIDENVK-- 63 LP ++ D +YE+ I G G L D+ N +V + G+ + + Sbjct: 108 LPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMA 167 Query: 64 -REIINHRSLRHPNIVR-FKEVILTPTHL----AIVMEYASGGELFERICNAGRFSEDEA 117 R+ + + HP+IV+ F V T H IVMEY GG+ +R + EA Sbjct: 168 ERQFLAE--VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKR-SKGQKLPVAEA 223 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 + +++ +SY H++ + + DLK EN +L +LK+ D G S ++S Sbjct: 224 IAYLLEILPALSYLHSIGLVYNDLKPENIMLT---EEQLKLIDLG--AVSRINSF-GYLY 277 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM 210 GTP + APE++ + D+++ G TL + Sbjct: 278 GTPGFQAPEIV--RTGPTVATDIYTVGRTLAAL 308 >5X18-A nrPDB Length = 295 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 97/224 (43%), Gaps = 22/224 (9%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI----DENVKREIINHRSLRHPN 76 Y++ K IG G+FGV + + VA+K+ R + DE +I+N PN Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGT----PN 64 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQ 135 I H +V++ G L + GR FS Q+I+ + HA Sbjct: 65 IPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHD 123 Query: 136 VCHRDLKLENTLLD--GSP-APRLKICDFGY--------SKSSVLHSQPKSTVGTPAYIA 184 + +RD+K +N L+ G P A + + DFG +K + + + KS GT Y++ Sbjct: 124 LIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMS 183 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRK 228 L +E + D+ + G + L G P++ + P N +K Sbjct: 184 INTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQK 226 >4MWI-A nrPDB Length = 294 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 52/228 (22%), Positives = 95/228 (41%), Gaps = 22/228 (9%) Query: 58 IDENVKREIINHRSLRHPNIVRFKEVIL----TPTHLAIVMEYASGGELFERICNAGRFS 113 + + +EI + PNI+R + + TP +IVMEY G L E + + Sbjct: 66 VRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLT 125 Query: 114 EDEARFFFQQLISGVSYCHAMQV--CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 171 + G+ H + H ++ N L+ + ++K+ F K+ S Sbjct: 126 LGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLV--TQGYQVKLAGFELRKTQTSMS 183 Query: 172 -----QPKSTVGTPAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK 224 + V + AY++P+ L + +YD K ++++S G+ L+ + G PF+ K Sbjct: 184 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVK-SEIYSFGIVLWEIATGDIPFQGCNSEK 242 Query: 225 NFRKTIHRILNVQYAIPDYVHISP-ECRHLISRIFVADPAKRISIPEI 271 I +++ V+ P E R +I DP+ R S+ EI Sbjct: 243 -----IRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEI 285 >3AOX-A nrPDB Length = 344 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 84/214 (39%), Gaps = 20/214 (9%) Query: 23 LVKDIGSGNFG-----VARLMRDKQSNELVAVKYIER--GEKIDENVKREIINHRSLRHP 75 L++ +G G FG M + S VAVK + E+ + + E + H Sbjct: 51 LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ 110 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE-------RICNAGRFSEDEARFFFQQLISGV 128 NIVR V L I++E +GG+L R + + + + G Sbjct: 111 NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGC 170 Query: 129 SYCHAMQVCHRDLKLENTLLDG-SPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIA 184 Y HRD+ N LL P KI DFG ++ + + + + ++ Sbjct: 171 QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMP 230 Query: 185 PEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPF 217 PE ++ + K D WS GV L+ + +G P+ Sbjct: 231 PEAFMEGIFTSK-TDTWSFGVLLWEIFSLGYMPY 263 >3SOC-A nrPDB Length = 322 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 79/186 (42%), Gaps = 26/186 (13%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF- 80 +L++ G FG + + + NE VAVK +K + E+ + ++H NI++F Sbjct: 27 QLLEVKARGRFGC--VWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFI 84 Query: 81 ---KEVILTPTHLAIVMEYASGGEL----------FERICNAGRFSEDEAR--FFFQQLI 125 K L ++ + G L + +C+ +E AR + + I Sbjct: 85 GAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCH---IAETMARGLAYLHEDI 141 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAY 182 G+ H + HRD+K +N LL + I DFG + ++ VGT Y Sbjct: 142 PGLKDGHKPAISHRDIKSKNVLLKNNLTA--CIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 183 IAPEVL 188 +APEVL Sbjct: 200 MAPEVL 205 >3QD2-B nrPDB Length = 332 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 16/104 (15%) Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGY--------SKSSVLHSQ 172 F Q+ V + H+ + HRDLK N +K+ DFG + +VL Sbjct: 170 FIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPM 227 Query: 173 P-----KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 P VGT Y++PE + Y KV D++S G+ L+ +L Sbjct: 228 PAYATHTGQVGTKLYMSPEQIHGNNYSHKV-DIFSLGLILFELL 270 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 2/62 (3%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPNIV 78 +E ++ +G G FGV ++K + A+K I E E V RE+ L HP IV Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 67 Query: 79 RF 80 R+ Sbjct: 68 RY 69 >6J5U-C nrPDB Length = 426 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 77/183 (42%), Gaps = 19/183 (10%) Query: 43 SNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGE 101 S +VAVK ++ G + + E+ L HPN+V + +V E+ G Sbjct: 117 SGIVVAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGS 176 Query: 102 LFERICNAGRFSEDEARFFFQQLIS-----GVSYCHAM--QVCHRDLKLENTLLDGSPAP 154 L + G + + ++ G+++ H QV +RD K N LLD Sbjct: 177 LENHLFRRG---AQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDAD--F 231 Query: 155 RLKICDFGYSKSSV----LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM 210 K+ DFG +K+ H K +GT Y APE + K +DV+S GV L + Sbjct: 232 NAKLSDFGLAKAGPTGDNTHVSTK-VIGTHGYAAPEYVATGRLTAK-SDVYSFGVVLLEL 289 Query: 211 LVG 213 + G Sbjct: 290 ISG 292 >4L00-A nrPDB Length = 304 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 84/208 (40%), Gaps = 27/208 (12%) Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF-FFQQLISGV 128 R + H +IV V + +V E+ GG L + +F +QL S + Sbjct: 87 RQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASAL 146 Query: 129 SYCHAMQVCHRDLKLENTLL-----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 SY + H ++ +N LL D P +K+ D G +VL Q + +I Sbjct: 147 SYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIP-ITVLSRQ--ECIERIPWI 203 Query: 184 APEVLLKKEYDGKVADVWSCGVTLY-VMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAI 240 APE + + AD WS G TL+ + G P +D E + F ++ R Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR-------- 255 Query: 241 PDYVHISPECRH---LISRIFVADPAKR 265 ++P C+ L++R DP +R Sbjct: 256 ----PVTPSCKELADLMTRCMNYDPNQR 279 >6BFN-A nrPDB Length = 342 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 81/208 (38%), Gaps = 26/208 (12%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGE-----KIDENVKREIINHRSLRHPNIVRFK 81 IG G FG + R N + AVK ++ + ++ E+ RHPNIV F Sbjct: 30 IGEGGFGC--VYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 87 Query: 82 EVILTPTHLAIVMEYASGGELFERI-CNAGR---FSEDEARFFFQQLISGVSYCH--AMQ 135 +V + G L +R+ C S + + + H + Sbjct: 88 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVGTPAYIAP 185 + H D+K N LLD P+L DFG ++ S + ++ ++ GT AY+ P Sbjct: 148 LIHGDIKSSNVLLDERLTPKLG--DFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-P 204 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVG 213 E +K D +S GV + L G Sbjct: 205 EEYIKTGRLAVDTDTFSFGVVVLETLAG 232 >4XHL-A nrPDB Length = 394 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 56/138 (40%), Gaps = 13/138 (9%) Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--- 166 RFS Q+ + Y H HRD+K +N L+ G + + DFG SK Sbjct: 99 RFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 Query: 167 -----SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED-- 219 + + + KS GT Y + L E + D+ S G L G+ P++ Sbjct: 159 FNTHRHIPYRENKSLTGTARYASVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLK 217 Query: 220 -PEEPKNFRKTIHRILNV 236 + + + + + + LNV Sbjct: 218 ATTKKQKYDRIMEKKLNV 235 >5CLR-A nrPDB Length = 451 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 54/99 (54%), Gaps = 14/99 (14%) Query: 118 RFFFQQLISGVSYCHAMQ------VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 171 + F++ L +S CH ++ + HRDLK N +LD L DFG S S Sbjct: 173 KHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHL--VDFGSSSSD---K 227 Query: 172 QPK-STVGTPAYIAPEVLLKKEYDG--KVADVWSCGVTL 207 +PK ++ GT +Y+APE+ ++++ +V+D+++ +L Sbjct: 228 EPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSL 266 >4XHH-A nrPDB Length = 403 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 10/105 (9%) Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQP 173 Q+I V Y H HRD+K +N L+ G + + DFG SK + + + Sbjct: 111 QMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYREN 170 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 KS GT Y + L E + D+ S G L G+ P++ Sbjct: 171 KSLTGTARYASVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQ 214 >4JRN-A nrPDB Length = 372 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 68/288 (23%), Positives = 106/288 (36%), Gaps = 73/288 (25%) Query: 27 IGSGNFGVARLMRDKQSNELVAVK-YIERGEKIDE---NVKREIINHRSLRHPNIV---- 78 +GSG F D ++NE +AVK ++ E DE +++RE +R+ Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 79 ---RF---------------KEVIL------TPTHLAIVMEY-ASGGELFERI-----CN 108 RF EV++ P + ++M A ++ + N Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 109 AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKS 166 F + Q I V+ A + H D+K N LL DG RL + DFG + Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDG----RLFLGDFGTYR- 250 Query: 167 SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV--ADVWSCGVTLYVMLVGAYPFEDPEEPK 224 +++ +GTP Y PE + D W G+TLY + P P Sbjct: 251 --INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP-----TPA 303 Query: 225 NFRKTIHRILNVQYAIPDYVHI-----SPE-CRHLISRIFVADPAKRI 266 + I DY+H +PE + LI + DP KR+ Sbjct: 304 D-------------GIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRM 338 >6EQI-C nrPDB Length = 433 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 15/108 (13%) Query: 127 GVSYCHAMQVCHRDLKLENTLLD---GSPAPRLKICDFGYS---KSSVL----HSQPKST 176 V++ + + HRDLK +N L+D G P + I DFG K + L S+ + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 177 VGTPAYIAPEVLLKKE-----YDGKVADVWSCGVTLYVMLVGAYPFED 219 G A +APE+ K + K +D+W+ G Y + PF D Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYD 286 >6EWX-A nrPDB Length = 484 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 74/198 (37%), Gaps = 45/198 (22%) Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL------------------------- 148 E F QL +G+ + + HRDL LEN LL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 149 ----------DGSPA----PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 G P PRL I +F +K + + A +APE++ +Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 + D + G+ +Y +L PFE + R+ +R ++ +P SP + L Sbjct: 328 -RKFDEFQTGILIYELLHQPNPFEVRAQ---LRERDYRREDLP-PLPTLSLYSPGLQQLA 382 Query: 255 SRIFVADPAKRISIPEIR 272 + ADP KRI I E + Sbjct: 383 HLLLEADPIKRIRIGEAK 400 >3G2F-A nrPDB Length = 336 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 80/198 (40%), Gaps = 34/198 (17%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 D D +L++ IG G +G + + VAVK + + ++ I + H N Sbjct: 11 DLDNLKLLELIGRGRYGA--VYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDN 68 Query: 77 IVRF---KEVILTPTHLA--IVMEYASGGELFERI-------CNAGRFSEDEAR---FFF 121 I RF E + + +VMEY G L + + ++ R + R + Sbjct: 69 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLH 128 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPK----- 174 +L G Y A + HRDL N L+ DG+ I DFG S + + Sbjct: 129 TELPRGDHYKPA--ISHRDLNSRNVLVKNDGTCV----ISDFGLSMRLTGNRLVRPGEED 182 Query: 175 ----STVGTPAYIAPEVL 188 S VGT Y+APEVL Sbjct: 183 NAAISEVGTIRYMAPEVL 200 >6BHC-A nrPDB Length = 438 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 26/167 (15%) Query: 126 SGVSYCHAMQVCHRDLKLENTLL-------------DGSPAP------RLKICDFGYSKS 166 SG+ + V H DL+LEN LL P P RL + +F +K Sbjct: 189 SGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQ 248 Query: 167 SVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 P+ + + +APE++ +Y K D + G+ +Y ML PF++ E K Sbjct: 249 KSHLVDPE-ILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKER 305 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 T + + + P S + L S + +P++RI I + + Sbjct: 306 EYTRADLPRIPFRSP----YSRGLQQLASCLLNPNPSERILISDAKG 348 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.048, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 20/167 (11%) Query: 17 DSDRYELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIERGEKIDE----------N 61 + +++ L K IGSG FG+ L +K + +V V+Y E G E + Sbjct: 14 EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKD 73 Query: 62 VKREIINHRSLRHPNIVRFKEVILTP----THLAIVMEYASGGELFERICNAGRFSEDEA 117 ++ I + L + I F LT ++ +VME G +L + G F + Sbjct: 74 CIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTV 132 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS 164 +++ + Y H + H D+K N LL ++ + D+G S Sbjct: 133 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 >5VE6-A nrPDB Length = 492 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 6/119 (5%) Query: 154 PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG 213 PRL I +F +K + + A +APE++ +Y + D + G+ +Y +L Sbjct: 296 PRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQY--RKFDEFQTGILIYELLHQ 353 Query: 214 AYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIR 272 PFE + R+ +R ++ +P SP + L + ADP KRI I E + Sbjct: 354 PNPFEVRAQ---LRERDYRQEDLP-PLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAK 408 >2GLJ-A nrPDB Length = 461 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 24/40 (60%) Query: 210 MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 +L+G+ P +D EE + + I +ILN +Y I + +S E Sbjct: 197 ILIGSIPLKDGEEKQKVKHNIMKILNEKYDISEEDFVSAE 236 >5UV4-A nrPDB Length = 311 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 72/180 (40%), Gaps = 13/180 (7%) Query: 46 LVAVKYIERG-EKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVM--EYASGGEL 102 ++ VK+++ G K + REI S+RHPN+V + P +M +YA L Sbjct: 51 MLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSL 110 Query: 103 FERIC-----NAGRFSEDEARFFFQQLISGVSYCHAMQVC-HRDLKLENTLLDGSPAPRL 156 + N S + + + Y H +V H ++K N L+ S P Sbjct: 111 STYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNS-TPSA 169 Query: 157 KICDFGYSK--SSVLHSQPKSTVGTPAYIAPEV-LLKKEYDGKVADVWSCGVTLYVMLVG 213 + D+ + + + ++ G Y PE K +DV++ GV L +L G Sbjct: 170 LVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTG 229 >6G4J-A nrPDB Length = 315 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 64/152 (42%), Gaps = 12/152 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLR- 73 + + Y L K +G G G+ L + S+ VA+K + I NV + +S+ Sbjct: 24 NGNTYTLRKQLGKGANGIVYLA--ETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTM 81 Query: 74 HPNIVRFKEVILTPTHLAI---VMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 P+ + + + + MEY G L + + + G + QL+S +S Sbjct: 82 GPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG---AEWIPVLMIQLLSSLSV 138 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 H DLK +N ++ G PA R++ D G Sbjct: 139 LHQQGWIFGDLKPDNLIVTGPPA-RIRCIDVG 169 >2RSV-A nrPDB Length = 403 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 26/56 (46%) Query: 107 CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 NA RFS +++ + Y H + H D+K N LL+ ++ + D+G Sbjct: 151 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 206 >2LAV-A nrPDB Length = 361 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 26/56 (46%) Query: 107 CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 NA RFS +++ + Y H + H D+K N LL+ ++ + D+G Sbjct: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 >5XU1-M nrPDB Length = 419 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 25/52 (48%), Gaps = 1/52 (1%) Query: 62 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFS 113 VK EII RSLR + F VIL L+I + + S E ++ FS Sbjct: 144 VKNEIIAGRSLREQDFKEFASVILLDEELSISL-FESPQEAINKVVEVNGFS 194 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3ZUT-A nrPDB 520 e-148 3UDB-A nrPDB 458 e-129 3UC3-A nrPDB 451 e-127 5WAX-A nrPDB 437 e-123 4REW-A nrPDB 316 1e-86 4CFH-A nrPDB 316 1e-86 4CFF-A nrPDB 315 2e-86 4MVF-A nrPDB 312 2e-85 3DXN-A nrPDB 310 4e-85 5J5T-A nrPDB 310 6e-85 4RED-A nrPDB 310 7e-85 2QNJ-A nrPDB 309 1e-84 5EZV-A nrPDB 307 3e-84 5JN2-A nrPDB 307 4e-84 3HZT-A nrPDB 307 5e-84 5ES1-A nrPDB 305 2e-83 5FG8-A nrPDB 304 3e-83 3MA6-A nrPDB 304 4e-83 3NCG-A nrPDB 302 1e-82 3DFA-A nrPDB 302 1e-82 3H4J-B nrPDB 302 2e-82 2VN9-A nrPDB 301 3e-82 2YZA-A nrPDB 300 4e-82 5KZ7-A nrPDB 300 5e-82 2W4O-A nrPDB 300 5e-82 3MN3-A nrPDB 300 7e-82 3LIJ-A nrPDB 299 1e-81 2BDW-A nrPDB 299 1e-81 4CZT-A nrPDB 299 1e-81 4FG9-A nrPDB 297 4e-81 5U6Y-A nrPDB 297 4e-81 2V7O-A nrPDB 297 7e-81 3KK8-A nrPDB 296 8e-81 2JC6-A nrPDB 296 8e-81 3BHH-A nrPDB 296 9e-81 5IG1-A nrPDB 296 1e-80 2VZ6-A nrPDB 294 3e-80 4D28-A nrPDB 294 4e-80 4YZB-A nrPDB 294 5e-80 5Z33-A nrPDB 293 7e-80 5YKS-A nrPDB 290 4e-79 2JAM-A nrPDB 290 7e-79 3SOA-A nrPDB 289 1e-78 3Q5I-A nrPDB 289 2e-78 4RGJ-A nrPDB 286 9e-78 3F3Z-A nrPDB 286 1e-77 4CQG-A nrPDB 284 3e-77 2HAK-A nrPDB 283 1e-76 6C9D-A nrPDB 282 2e-76 4D2V-A nrPDB 280 5e-76 4UZD-A nrPDB 280 6e-76 3D2K-A nrPDB 279 1e-75 4YNZ-A nrPDB 279 1e-75 5XZW-A nrPDB 277 4e-75 3NYO-A nrPDB 277 6e-75 4NIF-A nrPDB 277 7e-75 2J90-A nrPDB 277 7e-75 2YCR-A nrPDB 276 9e-75 1FOT-A nrPDB 276 1e-74 5JZN-A nrPDB 275 1e-74 2BPM-A nrPDB 275 2e-74 3HDN-A nrPDB 275 2e-74 1NY3-A nrPDB 274 6e-74 2OZA-A nrPDB 272 1e-73 3GUB-A nrPDB 272 1e-73 6FDY-U nrPDB 272 1e-73 3KA0-A nrPDB 272 2e-73 1PHK-A nrPDB 272 2e-73 5D9K-A nrPDB 271 3e-73 2JDO-A nrPDB 270 5e-73 3I6U-A nrPDB 270 5e-73 4JG6-A nrPDB 270 8e-73 2YAB-A nrPDB 270 8e-73 3FXW-A nrPDB 269 1e-72 2Y7J-A nrPDB 269 2e-72 3TAC-A nrPDB 269 2e-72 3MV5-A nrPDB 268 3e-72 3UTO-A nrPDB 267 4e-72 5KCV-A nrPDB 267 5e-72 4PDS-A nrPDB 266 9e-72 3IS5-A nrPDB 266 1e-71 4L42-A nrPDB 265 1e-71 6CMJ-A nrPDB 265 2e-71 4AW2-A nrPDB 265 2e-71 2A27-A nrPDB 265 2e-71 1KOA-A nrPDB 265 2e-71 1ZWS-A nrPDB 265 2e-71 2Z7Q-A nrPDB 265 3e-71 5N23-A nrPDB 265 3e-71 3KN6-A nrPDB 265 3e-71 2X4F-A nrPDB 265 3e-71 3COM-A nrPDB 264 4e-71 4RLP-A nrPDB 264 4e-71 3OHT-A nrPDB 263 8e-71 5FET-A nrPDB 263 1e-70 1KOB-A nrPDB 263 1e-70 4B6L-A nrPDB 263 1e-70 5X3F-B nrPDB 262 1e-70 3NIZ-A nrPDB 262 1e-70 5DYK-A nrPDB 262 1e-70 4LG4-A nrPDB 262 2e-70 4I6B-A nrPDB 261 4e-70 4WB7-A nrPDB 261 4e-70 2HW6-A nrPDB 260 6e-70 4TNB-A nrPDB 260 8e-70 3DB8-A nrPDB 260 8e-70 4EWQ-A nrPDB 260 9e-70 6AO5-A nrPDB 259 1e-69 6E9W-A nrPDB 258 2e-69 4JXF-A nrPDB 258 2e-69 1VZO-A nrPDB 258 2e-69 1CM8-A nrPDB 257 5e-69 4CSV-A nrPDB 257 5e-69 5YV8-A nrPDB 257 7e-69 4QMW-A nrPDB 256 1e-68 6GU6-A nrPDB 255 2e-68 6FD3-A nrPDB 255 3e-68 3TXO-A nrPDB 254 4e-68 6ED6-A nrPDB 253 6e-68 3ORZ-A nrPDB 253 8e-68 6DTL-A nrPDB 253 9e-68 5O2C-A nrPDB 253 1e-67 3DAK-A nrPDB 252 1e-67 4AGU-A nrPDB 252 1e-67 4FIE-A nrPDB 252 2e-67 4B8L-A nrPDB 252 2e-67 2OU7-A nrPDB 252 2e-67 4AU8-A nrPDB 252 2e-67 3TKU-A nrPDB 251 3e-67 4JDH-A nrPDB 251 3e-67 2Q0N-A nrPDB 251 3e-67 5F9E-A nrPDB 251 4e-67 4J52-A nrPDB 251 4e-67 4XBR-A nrPDB 250 6e-67 3HKO-A nrPDB 250 6e-67 4KRC-A nrPDB 250 7e-67 2F57-A nrPDB 250 9e-67 2BRG-A nrPDB 249 1e-66 4C0T-A nrPDB 249 1e-66 3A8W-A nrPDB 249 2e-66 5AWM-A nrPDB 249 2e-66 1V0B-A nrPDB 248 2e-66 4MYG-A nrPDB 248 2e-66 4KS7-A nrPDB 248 2e-66 4QNY-A nrPDB 248 3e-66 4IC8-A nrPDB 248 3e-66 4FZF-B nrPDB 248 3e-66 4BBM-A nrPDB 247 4e-66 6CKI-A nrPDB 247 6e-66 4AF3-A nrPDB 247 6e-66 4RA4-A nrPDB 246 9e-66 3GC0-A nrPDB 246 9e-66 3GC9-A nrPDB 246 1e-65 5NGU-A nrPDB 246 1e-65 3C51-A nrPDB 246 1e-65 4APC-A nrPDB 246 1e-65 3Q53-A nrPDB 245 2e-65 2XIK-A nrPDB 245 2e-65 4ZSG-A nrPDB 245 2e-65 1JNK-A nrPDB 245 2e-65 3ZDU-A nrPDB 245 2e-65 6QAU-A nrPDB 245 3e-65 5LOH-A nrPDB 244 4e-65 5UUU-A nrPDB 244 4e-65 3PVW-A nrPDB 244 5e-65 3E7O-A nrPDB 243 6e-65 2F9G-A nrPDB 243 6e-65 6BDL-A nrPDB 243 7e-65 2XS0-A nrPDB 243 9e-65 5DBX-A nrPDB 242 1e-64 4XEY-B nrPDB 242 2e-64 2FO0-A nrPDB 242 2e-64 4QTB-A nrPDB 241 3e-64 4WNO-A nrPDB 241 3e-64 3PFQ-A nrPDB 241 4e-64 1UA2-A nrPDB 240 5e-64 3M42-A nrPDB 240 9e-64 2I0E-A nrPDB 240 1e-63 5D7A-A nrPDB 239 1e-63 6CCF-A nrPDB 239 1e-63 3OZ6-A nrPDB 238 3e-63 2H8H-A nrPDB 238 3e-63 2UV2-A nrPDB 238 4e-63 5Y86-A nrPDB 238 4e-63 1G3N-A nrPDB 237 5e-63 2VD5-A nrPDB 237 6e-63 6CQF-A nrPDB 237 9e-63 2WQN-A nrPDB 236 1e-62 4YHJ-A nrPDB 236 1e-62 1TKI-A nrPDB 236 1e-62 2XYN-A nrPDB 235 2e-62 6HXF-B nrPDB 235 2e-62 3MIA-A nrPDB 235 2e-62 6F3F-A nrPDB 235 2e-62 3FI2-A nrPDB 235 3e-62 3PPZ-A nrPDB 235 3e-62 6NPU-A nrPDB 235 3e-62 5AIR-A nrPDB 234 3e-62 4FR4-A nrPDB 234 4e-62 4HZS-A nrPDB 234 4e-62 5EFQ-A nrPDB 234 6e-62 4E7W-A nrPDB 233 6e-62 6E2O-A nrPDB 233 6e-62 3LM0-A nrPDB 233 8e-62 1U5R-A nrPDB 232 1e-61 4NST-A nrPDB 232 2e-61 2GCD-A nrPDB 231 3e-61 6BXI-A nrPDB 230 7e-61 5TUR-A nrPDB 230 7e-61 3BGP-A nrPDB 230 9e-61 4GS6-A nrPDB 230 1e-60 4RC3-A nrPDB 229 1e-60 5SYS-A nrPDB 229 2e-60 4BGQ-A nrPDB 229 2e-60 4UYA-A nrPDB 228 2e-60 5H2U-A nrPDB 228 3e-60 5ZTN-A nrPDB 228 3e-60 5VO2-A nrPDB 228 3e-60 4O2Z-A nrPDB 227 5e-60 2DQ7-X nrPDB 227 9e-60 5G6V-A nrPDB 226 1e-59 4U41-A nrPDB 226 1e-59 4UY9-A nrPDB 226 1e-59 5X5O-A nrPDB 226 1e-59 4P5Q-A nrPDB 226 1e-59 3DTC-A nrPDB 225 2e-59 6DBM-A nrPDB 225 3e-59 4AN9-A nrPDB 223 6e-59 4OLI-A nrPDB 223 7e-59 5MJB-A nrPDB 223 1e-58 3A4O-X nrPDB 223 1e-58 4OTD-A nrPDB 223 1e-58 2W96-B nrPDB 222 1e-58 2I6L-A nrPDB 222 1e-58 1JPA-A nrPDB 222 2e-58 3PG1-A nrPDB 222 2e-58 2HK5-A nrPDB 221 3e-58 2Y6O-A nrPDB 221 3e-58 5L6P-A nrPDB 221 4e-58 3DKO-A nrPDB 221 4e-58 2WTK-C nrPDB 220 5e-58 2XNP-A nrPDB 220 6e-58 1U54-B nrPDB 220 6e-58 4CRS-A nrPDB 220 6e-58 4E93-A nrPDB 220 7e-58 4X7Q-B nrPDB 220 9e-58 2R2P-A nrPDB 219 2e-57 3ALO-A nrPDB 219 2e-57 6FEX-A nrPDB 218 2e-57 1AD5-A nrPDB 218 2e-57 3QGY-A nrPDB 218 3e-57 6BSD-A nrPDB 218 3e-57 3VN9-A nrPDB 218 3e-57 2VWV-A nrPDB 218 3e-57 3TT0-A nrPDB 217 7e-57 5A46-A nrPDB 217 8e-57 3V5Q-A nrPDB 217 9e-57 3RP9-A nrPDB 217 9e-57 2PL0-A nrPDB 216 1e-56 1FVR-A nrPDB 216 2e-56 4XCU-A nrPDB 216 2e-56 3FME-A nrPDB 215 2e-56 6GVJ-A nrPDB 215 2e-56 3E3P-A nrPDB 215 2e-56 2PSQ-A nrPDB 215 2e-56 5O0Y-A nrPDB 215 2e-56 5O2B-A nrPDB 215 2e-56 4E20-A nrPDB 215 3e-56 4PDO-A nrPDB 215 3e-56 3GQL-A nrPDB 215 3e-56 6DBN-A nrPDB 215 4e-56 4PWN-A nrPDB 214 4e-56 5KKR-C nrPDB 214 4e-56 3KUL-B nrPDB 214 5e-56 3DLS-A nrPDB 214 5e-56 4AT3-A nrPDB 214 6e-56 4EQM-A nrPDB 213 1e-55 3SXS-A nrPDB 212 2e-55 3EQC-A nrPDB 212 2e-55 5KMM-A nrPDB 212 3e-55 4Y93-A nrPDB 211 3e-55 3ORP-A nrPDB 211 3e-55 6O6Q-A nrPDB 211 4e-55 3N9X-A nrPDB 211 4e-55 3EB0-A nrPDB 211 4e-55 1ZXE-A nrPDB 211 5e-55 3HMP-A nrPDB 210 6e-55 5HVK-A nrPDB 210 7e-55 2W1I-A nrPDB 209 1e-54 5AMN-A nrPDB 209 2e-54 2ZMD-A nrPDB 209 2e-54 5AP3-A nrPDB 208 2e-54 4XI2-A nrPDB 208 3e-54 6FER-A nrPDB 208 4e-54 4KIK-B nrPDB 208 4e-54 5EG3-A nrPDB 207 5e-54 3OMV-A nrPDB 207 7e-54 3NIE-A nrPDB 207 8e-54 3IO7-A nrPDB 206 8e-54 4Y83-A nrPDB 206 1e-53 4K33-A nrPDB 206 2e-53 6E4F-A nrPDB 206 2e-53 5HI2-A nrPDB 206 2e-53 3QA8-A nrPDB 205 2e-53 5X8I-B nrPDB 205 3e-53 3ZBF-A nrPDB 204 5e-53 5HIE-A nrPDB 204 5e-53 5FM2-A nrPDB 204 6e-53 1S9I-A nrPDB 203 8e-53 3BBT-B nrPDB 203 1e-52 4HVI-A nrPDB 203 1e-52 1LUF-A nrPDB 203 1e-52 4IDT-A nrPDB 202 2e-52 5TQX-A nrPDB 201 3e-52 5U6B-A nrPDB 200 9e-52 4F0G-A nrPDB 200 1e-51 3QUP-A nrPDB 200 1e-51 5B2L-A nrPDB 198 2e-51 4C59-A nrPDB 198 2e-51 4TPT-A nrPDB 198 3e-51 3PLS-A nrPDB 197 5e-51 2WO6-A nrPDB 197 6e-51 3LZB-A nrPDB 196 1e-50 3PP0-A nrPDB 196 1e-50 3C1X-A nrPDB 195 2e-50 6FYV-A nrPDB 195 2e-50 5HLW-A nrPDB 195 2e-50 4G3E-A nrPDB 195 3e-50 5GNK-A nrPDB 195 3e-50 5TE0-A nrPDB 195 4e-50 1U59-A nrPDB 194 5e-50 6HMD-A nrPDB 194 5e-50 5WNO-A nrPDB 194 7e-50 5UIU-A nrPDB 193 8e-50 2OZO-A nrPDB 193 8e-50 3RAW-A nrPDB 193 1e-49 4OW8-A nrPDB 192 2e-49 4X3F-A nrPDB 192 2e-49 6B2Q-A nrPDB 192 2e-49 2A1A-B nrPDB 192 2e-49 4MD7-E nrPDB 191 3e-49 4LRM-A nrPDB 190 6e-49 3AOX-A nrPDB 190 1e-48 5UNP-A nrPDB 189 2e-48 5XVU-A nrPDB 189 2e-48 4CRL-A nrPDB 188 3e-48 2BUJ-A nrPDB 188 3e-48 2WTK-B nrPDB 188 4e-48 5VD3-A nrPDB 188 4e-48 4NEU-A nrPDB 188 4e-48 6EII-A nrPDB 187 5e-48 5IKW-A nrPDB 187 5e-48 3UIU-A nrPDB 187 6e-48 6CTH-A nrPDB 186 9e-48 4M7I-A nrPDB 186 9e-48 4YFF-A nrPDB 185 2e-47 2PVN-A nrPDB 185 3e-47 4JLC-A nrPDB 185 3e-47 4EUU-A nrPDB 183 1e-46 5TOS-A nrPDB 183 1e-46 4EUT-A nrPDB 182 2e-46 4FL3-A nrPDB 181 4e-46 3MDY-A nrPDB 181 4e-46 5VC6-A nrPDB 181 6e-46 3Q4U-A nrPDB 180 1e-45 3MY0-A nrPDB 180 1e-45 6J5U-C nrPDB 180 1e-45 6O8B-A nrPDB 179 1e-45 6NT9-A nrPDB 179 1e-45 5C26-A nrPDB 178 3e-45 5LPZ-A nrPDB 178 3e-45 5LPV-A nrPDB 178 4e-45 3ZZW-A nrPDB 177 6e-45 5CEK-A nrPDB 177 6e-45 6DC0-A nrPDB 177 7e-45 4IAN-A nrPDB 176 9e-45 2RIO-A nrPDB 176 1e-44 1PY5-A nrPDB 176 2e-44 6HV0-A nrPDB 175 3e-44 4PL5-B nrPDB 171 4e-43 3LLT-A nrPDB 171 5e-43 2Y4I-B nrPDB 170 7e-43 3LMG-A nrPDB 170 1e-42 5XD6-A nrPDB 170 1e-42 2JD5-A nrPDB 169 2e-42 4WUA-A nrPDB 168 3e-42 2X7G-A nrPDB 167 8e-42 5L2Q-C nrPDB 166 1e-41 2H34-A nrPDB 166 1e-41 5AR8-A nrPDB 166 2e-41 4LFI-A nrPDB 165 2e-41 4LQP-A nrPDB 165 2e-41 3UIM-A nrPDB 164 6e-41 5VDK-A nrPDB 163 1e-40 5E8V-A nrPDB 163 2e-40 3SV0-A nrPDB 162 2e-40 3SOC-A nrPDB 161 4e-40 4M66-A nrPDB 161 5e-40 2PMN-X nrPDB 161 6e-40 4TN6-A nrPDB 160 7e-40 5FQD-C nrPDB 160 1e-39 6BFN-A nrPDB 158 3e-39 4F9B-A nrPDB 154 4e-38 4MWI-A nrPDB 154 6e-38 3REP-A nrPDB 154 6e-38 2QKW-B nrPDB 154 7e-38 5X18-A nrPDB 153 1e-37 2QLU-A nrPDB 153 1e-37 4BTK-A nrPDB 150 9e-37 4NFN-A nrPDB 149 2e-36 2CMW-A nrPDB 147 6e-36 2CHL-A nrPDB 146 1e-35 1CSN-A nrPDB 146 1e-35 5X1R-A nrPDB 146 2e-35 2C47-A nrPDB 145 3e-35 4NT4-A nrPDB 144 5e-35 3QD2-B nrPDB 143 1e-34 4L00-A nrPDB 142 3e-34 5J0A-A nrPDB 141 4e-34 5M07-A nrPDB 141 5e-34 4XHH-A nrPDB 137 6e-33 2PZI-A nrPDB 137 9e-33 4Y12-A nrPDB 136 2e-32 4XHL-A nrPDB 135 3e-32 5OAT-A nrPDB 116 1e-26 4JRN-A nrPDB 115 4e-26 5CLR-A nrPDB 86 2e-17 Sequences not found previously or not previously below threshold: 4EBW-A nrPDB 228 2e-60 2J0K-A nrPDB 224 4e-59 6GQK-A nrPDB 210 7e-55 1K9A-A nrPDB 207 5e-54 4XUF-A nrPDB 207 6e-54 5X02-A nrPDB 206 1e-53 1BYG-A nrPDB 206 2e-53 3BEA-A nrPDB 204 6e-53 4H1J-A nrPDB 203 8e-53 2OGV-A nrPDB 203 1e-52 3G0E-A nrPDB 200 8e-52 3KRL-A nrPDB 200 8e-52 4R7H-A nrPDB 199 1e-51 4XLV-A nrPDB 199 2e-51 3CJF-A nrPDB 198 3e-51 5GRN-A nrPDB 198 4e-51 3I81-A nrPDB 186 1e-47 5U6C-A nrPDB 184 5e-47 5WNL-A nrPDB 173 7e-44 4M69-B nrPDB 144 7e-35 4BTF-A nrPDB 143 1e-34 3G2F-A nrPDB 143 1e-34 3HNG-A nrPDB 139 2e-33 3VHK-A nrPDB 139 2e-33 5USZ-A nrPDB 135 3e-32 4RT7-A nrPDB 132 3e-31 5C01-A nrPDB 127 1e-29 4WOV-A nrPDB 126 2e-29 5UV4-A nrPDB 111 5e-25 6EQI-C nrPDB 108 4e-24 4I94-A nrPDB 106 2e-23 4L68-A nrPDB 104 8e-23 6J6I-B nrPDB 99 3e-21 5UU1-A nrPDB 94 8e-20 4IX6-A nrPDB 88 4e-18 2RSV-A nrPDB 88 5e-18 2LAV-A nrPDB 87 1e-17 5DMZ-A nrPDB 83 3e-16 6G4J-A nrPDB 82 4e-16 4O1O-A nrPDB 81 1e-15 6EAS-A nrPDB 76 2e-14 6EWX-A nrPDB 76 3e-14 4CI6-B nrPDB 71 6e-13 5VE6-A nrPDB 70 1e-12 4OAU-C nrPDB 70 2e-12 6BHC-A nrPDB 69 2e-12 2JII-A nrPDB 63 2e-10 6M7Z-A nrPDB 59 2e-09 5GZ9-A nrPDB 56 3e-08 6G38-A nrPDB 53 1e-07 4CYJ-A nrPDB 53 2e-07 5GZA-A nrPDB 53 3e-07 4BWP-A nrPDB 51 1e-06 4AZW-A nrPDB 50 2e-06 4AZV-A nrPDB 49 2e-06 3BYV-A nrPDB 49 3e-06 4CZY-B nrPDB 48 5e-06 2W1Z-A nrPDB 48 6e-06 3ENH-A nrPDB 47 1e-05 3DZO-A nrPDB 46 2e-05 3Q60-A nrPDB 42 4e-04 6FBK-A nrPDB 40 0.001 4WWA-A nrPDB 39 0.002 1TQM-A nrPDB 38 0.005 2LRU-A nrPDB 38 0.008 4BVU-A nrPDB 35 0.047 4H05-A nrPDB 33 0.21 5YK0-A nrPDB 32 0.36 6G5I-z nrPDB 32 0.39 4OTP-A nrPDB 32 0.43 6EF6-A nrPDB 32 0.54 6G18-v nrPDB 30 1.6 4GYG-A nrPDB 30 2.2 >3ZUT-A nrPDB Length = 362 Score = 520 bits (1339), Expect = e-148, Method: Composition-based stats. Identities = 361/362 (99%), Positives = 361/362 (99%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE Sbjct: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF Sbjct: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC FGYSKSSVLHSQPKSTVGTP Sbjct: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTP 180 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ Sbjct: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 Query: 301 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY 360 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY Sbjct: 301 PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVY 360 Query: 361 AM 362 AM Sbjct: 361 AM 362 >3UDB-A nrPDB Length = 317 Score = 458 bits (1179), Expect = e-129, Method: Composition-based stats. Identities = 309/317 (97%), Positives = 313/317 (98%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 MDRPAV+GPMDLPIMHDSDRYELVKDIG+GNFGVARLMRDKQ+NELVAVKYIERGEKIDE Sbjct: 1 MDRPAVAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF Sbjct: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 180 FQQLISGVSY HAMQV HRDLKLENTLLDGSPAPRLKI DFGYSK+SVLHSQPKS VGTP Sbjct: 121 FQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTP 180 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ Sbjct: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 Query: 301 PGQSIEEIMQIIAEATV 317 PGQSIEEIMQIIAEATV Sbjct: 301 PGQSIEEIMQIIAEATV 317 >3UC3-A nrPDB Length = 361 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 286/363 (78%), Positives = 327/363 (90%), Gaps = 3/363 (0%) Query: 1 MDR-PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 MDR P +GP+D+PIMHDSDRY+ VKDIGSGNFGVARLMRDK + ELVAVKYIERG ID Sbjct: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID 60 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 FFQQL+SGVSYCH+MQ+CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT Sbjct: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 Query: 300 QPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIV 359 QP QS++ IMQII+EAT+P + L+ ++T +LD+DDDM++ ++DIDSSGEIV Sbjct: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSE--SEIDIDSSGEIV 358 Query: 360 YAM 362 YA+ Sbjct: 359 YAL 361 >5WAX-A nrPDB Length = 310 Score = 437 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 273/309 (88%), Positives = 296/309 (95%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 MD+PIMHD DRYELV+DIGSGNFGVARLMR++ +LVAVKYIERGEKIDENV+REIINH Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINH 61 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 RSLRHPNI+RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS Sbjct: 62 RSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 YCH+MQVCHRDLKLENTLLDGS APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDP+EPKNFRKTI RIL VQY+IPDYVHISPE Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 C+ LISRIFVA+PA RI+IPEIRNH WFLKNLPADLM+D+TM+ Q++E +QP QS++EIM Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDEIM 301 Query: 310 QIIAEATVP 318 QI+AEAT+P Sbjct: 302 QILAEATIP 310 >4REW-A nrPDB Length = 540 Score = 316 bits (809), Expect = 1e-86, Method: Composition-based stats. Identities = 112/292 (38%), Positives = 159/292 (54%), Gaps = 12/292 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHP 75 Y L +G G FG ++ + + + VAVK + R + + ++REI N + RHP Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R FQQ++SGV YCH Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 127 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 184 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WS GV LY +L G PF+D P F+K I + P Y++ P L+ Sbjct: 185 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQYLN--PSVISLLK 238 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 + DP KR SI +IR HEWF ++LP L ++ + D+ + + E Sbjct: 239 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCE 290 >4CFH-A nrPDB Length = 493 Score = 316 bits (809), Expect = 1e-86, Method: Composition-based stats. Identities = 116/309 (37%), Positives = 164/309 (53%), Gaps = 16/309 (5%) Query: 7 SGPMDLPIMHDSD----RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN- 61 GPM HD Y L +G G FG ++ + + + VAVK + R + + Sbjct: 17 QGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDV 76 Query: 62 ---VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR 118 ++REI N + RHP+I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R Sbjct: 77 VGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR 136 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 FQQ++SGV YCH V HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCG 194 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 +P Y APEV+ + Y G D+WS GV LY +L G PF+D P F+K I + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----F 250 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDES 298 P Y++ P L+ + DP KR +I +IR HEWF ++LP L ++ + Sbjct: 251 YTPQYLN--PSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 308 Query: 299 DQPGQSIEE 307 D+ + + E Sbjct: 309 DEALKEVCE 317 >4CFF-A nrPDB Length = 571 Score = 315 bits (807), Expect = 2e-86, Method: Composition-based stats. Identities = 120/309 (38%), Positives = 164/309 (53%), Gaps = 16/309 (5%) Query: 7 SGPMDLPIMHDSD----RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN- 61 GPM HD Y L +G G FG ++ + + VAVK + R + + Sbjct: 17 QGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV 76 Query: 62 ---VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR 118 +KREI N + RHP+I++ +VI TPT +VMEY SGGELF+ IC GR E EAR Sbjct: 77 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 136 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 FQQ++S V YCH V HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCG 194 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 +P Y APEV+ + Y G D+WSCGV LY +L G PF+D P F+K I + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVF 250 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDES 298 IP+Y++ S L+ + DP KR +I +IR HEWF ++LP+ L ++ Sbjct: 251 YIPEYLNRS--VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID 308 Query: 299 DQPGQSIEE 307 D+ + + E Sbjct: 309 DEAVKEVCE 317 >4MVF-A nrPDB Length = 506 Score = 312 bits (799), Expect = 2e-85, Method: Composition-based stats. Identities = 102/367 (27%), Positives = 169/367 (46%), Gaps = 29/367 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINHRSLRHPN 76 D+Y + + +G G +G DK +N+L A+K ++ + +EI + L HPN Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPN 115 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV+ E ++ ++ME SG ELF+ I G F+E A +Q+ S + Y H++ + Sbjct: 116 IVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 137 CHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 HRDLK EN L + LKI DFG SK+ + GTP Y+AP+VL K Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK--YD 233 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPECRHL 253 K D+WS GV +Y +L G PF + + + ++ ++ D+ IS + ++L Sbjct: 234 KKCDIWSSGVIMYTLLCGYPPFYGDTD----NEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT-----TQFDESDQ-------- 300 I+++ +P +R +I E NH W + + + + T F + ++ Sbjct: 290 ITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALTI 349 Query: 301 -----PGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDID-DDMEEDLESDLDDLDIDS 354 I + I V +GT + L G I + D+ L D+D ++ Sbjct: 350 IAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLKKIGYQKIPPDIHQVLRDIDSNA 409 Query: 355 SGEIVYA 361 SG+I Y Sbjct: 410 SGQIHYT 416 >3DXN-A nrPDB Length = 287 Score = 310 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 102/280 (36%), Positives = 152/280 (54%), Gaps = 13/280 (4%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----V 62 SG +L SDRY+ VK +GSG +G L +DK + A+K I++ + + Sbjct: 9 SGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGAL 68 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 E+ + L HPNI++ E + +VME GGELF+ I +FSE +A + Sbjct: 69 LDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK 128 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPA 181 Q++SG +Y H + HRDLK EN LL+ +KI DFG S + + K +GT Sbjct: 129 QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY 188 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI- 240 YIAPEVL +K+YD K DVWSCGV LY++L G PF + ++ + R+ +++ Sbjct: 189 YIAPEVL-RKKYDEK-CDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSFD 242 Query: 241 -PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 PD+ +S E + L+ + +P+KRIS E NH W +K Sbjct: 243 PPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >5J5T-A nrPDB Length = 370 Score = 310 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 91/362 (25%), Positives = 160/362 (44%), Gaps = 24/362 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV-KREIINHRSLRHPN 76 + +EL++ IGSG +G R+ + EL A+K I+ D V ++EII + +HPN Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPN 62 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV + L L I ME+ GG L + G SE + + ++ + G+ Y H+ Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEV--LLKKEY 193 HRD+K N LL + +K+ DFG S ++ K+ +GTP ++APEV + +K Sbjct: 123 MHRDIKGANILLTDN--GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP---DYVHISPEC 250 ++ D+W+ G+T + P D + + + + P D + S Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHP----MRALFLMTKSNFQPPKLKDKMKWSNSF 236 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLKNLPADL-------MNDNTMTTQFDESDQPGQ 303 H + +P KR + ++ H + ++L L +N+ +T D D + Sbjct: 237 HHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPE 296 Query: 304 SIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLE--SDLDDLD--IDSSGEIV 359 + + I + + + G + D + ++ E +L D D +DSS EI Sbjct: 297 PLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIY 356 Query: 360 YA 361 Y Sbjct: 357 YT 358 >4RED-A nrPDB Length = 351 Score = 310 bits (794), Expect = 7e-85, Method: Composition-based stats. Identities = 112/292 (38%), Positives = 159/292 (54%), Gaps = 12/292 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHP 75 Y L +G G FG ++ + + + VAVK + R + + ++REI N + RHP Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TP+ + +VMEY SGGELF+ IC GR E E+R FQQ++SGV YCH Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 135 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WS GV LY +L G PF+D P F+K I + P Y++ P L+ Sbjct: 193 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQYLN--PSVISLLK 246 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 + DP KR SI +IR HEWF ++LP L ++ + D+ + + E Sbjct: 247 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCE 298 >2QNJ-A nrPDB Length = 328 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 113/325 (34%), Positives = 165/325 (50%), Gaps = 12/325 (3%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---R 64 G M Y L+K IG GNF +L R + VA+K I++ + +++ R Sbjct: 1 GAMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFR 60 Query: 65 EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 E+ + L HPNIV+ EVI T L ++MEYASGGE+F+ + GR E EAR F+Q+ Sbjct: 61 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 120 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 +S V YCH ++ HRDLK EN LLD +KI DFG+S + + + G+P Y A Sbjct: 121 VSAVQYCHQKRIVHRDLKAENLLLDADM--NIKIADFGFSNEFTVGGKLDTFCGSPPYAA 178 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE+ K+YDG DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y Sbjct: 179 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY- 233 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQS 304 +S +C +L+ R V +P KR ++ +I W D + + + D SDQ Sbjct: 234 -MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL-KPFVEPELDISDQKRID 291 Query: 305 IEEIMQIIAEATVPPAGTQNLNHYL 329 I M E + Sbjct: 292 IMVGMGYSQEEIQESLSKMKYDEIT 316 >5EZV-A nrPDB Length = 560 Score = 307 bits (788), Expect = 3e-84, Method: Composition-based stats. Identities = 115/292 (39%), Positives = 159/292 (54%), Gaps = 12/292 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHP 75 Y L +G G FG ++ + + VAVK + R + + +KREI N + RHP Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 89 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 148 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 149 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 206 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 207 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLM 260 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 + DP KR +I +IR HEWF ++LP+ L ++ D+ + + E Sbjct: 261 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 312 >5JN2-A nrPDB Length = 525 Score = 307 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 95/266 (35%), Positives = 141/266 (53%), Gaps = 9/266 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLR 73 SDRY+ + +G G+FG L +DK + + AVK I + + E++ RE+ + L Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 125 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 185 Query: 134 MQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL+ S ++I DFG S + K +GT YIAPEVL Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG-T 244 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 245 YDEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEK--GKYTFELPQWKKVSESAKD 301 Query: 253 LISRIFVADPAKRISIPEIRNHEWFL 278 LI ++ P+ RIS + +HEW Sbjct: 302 LIRKMLTYVPSMRISARDALDHEWIQ 327 >3HZT-A nrPDB Length = 467 Score = 307 bits (787), Expect = 5e-84, Method: Composition-based stats. Identities = 99/269 (36%), Positives = 148/269 (55%), Gaps = 13/269 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLR 73 SDRY+ VK +GSG +G L +DK + A+K I++ + + E+ + L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +VME GGELF+ I +FSE +A +Q++SG +Y H Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 134 MQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 + HRDLK EN LL+ +KI DFG S + + K +GT YIAPEVL +K+ Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RKK 181 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPEC 250 YD K DVWSCGV LY++L G PF + ++ + R+ +++ PD+ +S E Sbjct: 182 YDEK-CDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSFDPPDWTQVSDEA 236 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLK 279 + L+ + +P+KRIS E NH W +K Sbjct: 237 KQLVKLMLTYEPSKRISAEEALNHPWIVK 265 >5ES1-A nrPDB Length = 328 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 109/313 (34%), Positives = 163/313 (52%), Gaps = 12/313 (3%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPN 76 Y L++ IG GNF +L R + VA+K I++ + +++ RE+ + L HPN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV+ EVI T L +VMEYAS GE+F+ + + GR E EAR F+Q++S V YCH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 135 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLD +KI DFG+S L S+ + G+P Y APE+ K+YDG Sbjct: 136 VHRDLKAENLLLDAE--ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 D+WS GV LY ++ G+ PF+ N ++ R+L +Y +P Y +S +C ++ R Sbjct: 194 EVDIWSLGVILYTLVSGSLPFDGH----NLKELRERVLRGKYRVPFY--MSTDCESILRR 247 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEAT 316 V +PAKR ++ +I +W + + T + D D + M E Sbjct: 248 FLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEE-DFGDTKRIEVMVGMGYTREEI 306 Query: 317 VPPAGTQNLNHYL 329 +Q N Sbjct: 307 KESLTSQKYNEVT 319 >5FG8-A nrPDB Length = 285 Score = 304 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 93/280 (33%), Positives = 143/280 (51%), Gaps = 10/280 (3%) Query: 8 GPMDLP--IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK-- 63 G M P SD Y++ +++G G F + + K + A K I + + + Sbjct: 1 GAMAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKL 60 Query: 64 -REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 RE R L HPNIVR + I + +V + +GGELFE I +SE +A Q Sbjct: 61 EREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQ 120 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTP 180 Q++ V++CH V HRDLK EN LL +K+ DFG + Q GTP Sbjct: 121 QILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP 180 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Y++PEVL K+ Y GK D+W+CGV LY++LVG PF D ++ + + + + Y Sbjct: 181 GYLSPEVLKKEPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI--KAGAYDYPS 237 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 P++ ++PE ++LI+++ +P KRI+ E H W + Sbjct: 238 PEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQR 277 >3MA6-A nrPDB Length = 298 Score = 304 bits (779), Expect = 4e-83, Method: Composition-based stats. Identities = 95/266 (35%), Positives = 141/266 (53%), Gaps = 9/266 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLR 73 SDRY+ + +G G+FG L +DK + + AVK I + + E++ RE+ + L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 90 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 150 Query: 134 MQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL+ S ++I DFG S + K +GT YIAPEVL Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG-T 209 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 210 YDEK-CDVWSTGVILYILLSGCPPFNGANEYDILKKVEK--GKYTFELPQWKKVSESAKD 266 Query: 253 LISRIFVADPAKRISIPEIRNHEWFL 278 LI ++ P+ RIS + +HEW Sbjct: 267 LIRKMLTYVPSMRISARDALDHEWIQ 292 >3NCG-A nrPDB Length = 486 Score = 302 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 140/266 (52%), Gaps = 8/266 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN---VKREIINHRSLRH 74 ++RY +V +G G+FG +D+ + + AVK I + +++ + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI++ E++ + IV E +GGELF+ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 135 QVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEVL Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D K DVWS GV LY++L G PF E ++ + +P + IS + + L Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNEYDILKRV--ETGKYAFDLPQWRTISDDAKDL 256 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLK 279 I ++ P+ RI+ + H W K Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >3DFA-A nrPDB Length = 286 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 140/266 (52%), Gaps = 8/266 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN---VKREIINHRSLRH 74 ++RY +V +G G+FG +D+ + + AVK I + +++ + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI++ E++ + IV E +GGELF+ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 135 QVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEVL Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D K DVWS GV LY++L G PF E ++ + +P + IS + + L Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNEYDILKRV--ETGKYAFDLPQWRTISDDAKDL 256 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLK 279 I ++ P+ RI+ + H W K Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >3H4J-B nrPDB Length = 336 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 119/292 (40%), Positives = 170/292 (58%), Gaps = 13/292 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----RGEKIDENVKREIINHRSLRHPN 76 Y + + +G G+FG +L ++ + VA+K+I + + V+REI + LRHP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I++ +VI TPT + +V+EYA GGELF+ I R +EDE R FFQQ+I + YCH ++ Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLD + +KI DFG S + K++ G+P Y APEV+ K Y G Sbjct: 130 VHRDLKPENLLLDDNL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWSCG+ LYVMLVG PF+D P F+K + + Y +PD+ +SP + LI R Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKK----VNSCVYVMPDF--LSPGAQSLIRR 241 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEI 308 + VADP +RI+I EIR WF NLP L + + +S + E + Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGEAM 293 >2VN9-A nrPDB Length = 301 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 93/282 (32%), Positives = 145/282 (51%), Gaps = 8/282 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +++G G F V R + + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I +V + +GGELFE I +SE +A QQ++ V++CH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 135 QVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 + HRDLK EN LL S +K+ DFG + Q GTP Y++PEVL K Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 239 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 LI+++ +PAKRI+ E H W + M T Sbjct: 240 LINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVD 281 >2YZA-A nrPDB Length = 276 Score = 300 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 113/273 (41%), Positives = 152/273 (55%), Gaps = 12/273 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHP 75 Y L +G G FG ++ + + VAVK + R + + +KREI N + RHP Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 131 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 V HRDLK EN LLD KI DFG S + + G+P Y APEV+ + Y G Sbjct: 132 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 190 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLM 243 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 + DP KR +I +IR HEWF ++LP+ L + Sbjct: 244 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 276 >5KZ7-A nrPDB Length = 346 Score = 300 bits (770), Expect = 5e-82, Method: Composition-based stats. Identities = 110/313 (35%), Positives = 163/313 (52%), Gaps = 12/313 (3%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPN 76 Y L+K IG GNF +L R + + VAVK I++ + +++ RE+ + L HPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 153 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLD +KI DFG+S ++ + G+P Y APE+ K+YDG Sbjct: 154 VHRDLKAENLLLDADM--NIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 211 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ + Sbjct: 212 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKK 265 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEAT 316 + +P+KR ++ +I W D + + D D + M E Sbjct: 266 FLILNPSKRGTLEQIMKDRWMNVGHEDDEL-KPYVEPLPDYKDPRRTELMVSMGYTREEI 324 Query: 317 VPPAGTQNLNHYL 329 Q N + Sbjct: 325 QDSLVGQRYNEVM 337 >2W4O-A nrPDB Length = 349 Score = 300 bits (769), Expect = 5e-82, Method: Composition-based stats. Identities = 97/302 (32%), Positives = 155/302 (51%), Gaps = 9/302 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 SD +E+ ++G G + + K + + A+K +++ + V+ EI L HPNI Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKK-TVDKKIVRTEIGVLLRLSHPNI 110 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 ++ KE+ TPT +++V+E +GGELF+RI G +SE +A +Q++ V+Y H + Sbjct: 111 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIV 170 Query: 138 HRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN L +P LKI DFG SK K+ GTP Y APE+L Y G Sbjct: 171 HRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GP 229 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI--PDYVHISPECRHLI 254 D+WS G+ Y++L G PF D E F RILN +Y P + +S + L+ Sbjct: 230 EVDMWSVGIITYILLCGFEPFYD-ERGDQFM--FRRILNCEYYFISPWWDEVSLNAKDLV 286 Query: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAE 314 ++ V DP KR++ + H W A+ ++ +T + E + + + ++A Sbjct: 287 RKLIVLDPKKRLTTFQALQHPWVTGKA-ANFVHMDTAQKKLQEFNARRKLKAAVKAVVAS 345 Query: 315 AT 316 + Sbjct: 346 SR 347 >3MN3-A nrPDB Length = 271 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 112/272 (41%), Positives = 154/272 (56%), Gaps = 13/272 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSLRHP 75 Y++VK +G G+FG +L + + VA+K I + + ++REI R LRHP Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +I++ +VI + + +V+EYA G ELF+ I + SE EAR FFQQ+IS V YCH + Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHK 123 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + HRDLK EN LLD +KI DFG S + K++ G+P Y APEV+ K Y G Sbjct: 124 IVHRDLKPENLLLDEHL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 DVWSCGV LYVML PF+D P F+ I N Y +P + +SP LI Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFK----NISNGVYTLPKF--LSPGAAGLIK 235 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 R+ + +P RISI EI +WF +LP L+ Sbjct: 236 RMLIVNPLNRISIHEIMQDDWFKVDLPEYLLP 267 >3LIJ-A nrPDB Length = 494 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 92/268 (34%), Positives = 141/268 (52%), Gaps = 8/268 (2%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSL 72 H S+ Y+ VK +GSG +G L RDK ++ A+K I + + + E+ + L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 HPNI++ + + +VME GGELF+ I + +F+E +A +Q++SGV+Y H Sbjct: 94 DHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 133 AMQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + HRDLK EN LL+ +KI DFG S + K +GT YIAPEVL +K Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL-RK 212 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 +YD K DVWS GV L+++L G PF + + RK + P++ ++S + Sbjct: 213 KYDEK-CDVWSIGVILFILLAGYPPFGGQTDQEILRKVEK--GKYTFDSPEWKNVSEGAK 269 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLK 279 LI ++ D +RIS + H W + Sbjct: 270 DLIKQMLQFDSQRRISAQQALEHPWIKE 297 >2BDW-A nrPDB Length = 362 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 86/264 (32%), Positives = 134/264 (50%), Gaps = 7/264 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRH 74 SD Y++ +++G G F V R K + A K I + + + RE R L+H Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 87 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I + +V + +GGELFE I +SE +A QQ++ ++YCH+ Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 135 QVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HR+LK EN LL +K+ DFG + GTP Y++PEVL K Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 K D+W+CGV LY++LVG PF D ++ + + + + Y P++ ++PE + L Sbjct: 208 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 264 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 I + +P KRI+ + W Sbjct: 265 IDSMLTVNPKKRITADQALKVPWI 288 >4CZT-A nrPDB Length = 464 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 113/302 (37%), Positives = 169/302 (55%), Gaps = 17/302 (5%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHP 75 +YEL + +G G F + R+ ++ + VA+K I++ + + +KREI + ++HP Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N++R EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V YCH+ Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 131 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 V HRDLK EN LLD + A LK+ DFG S + +T GTP Y+APEV+ K Sbjct: 132 VYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YDG AD+WSCGV L+V++ G PFED N +I ++ P + S + Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDS----NLTSLYKKIFKAEFTCPPW--FSASAKK 243 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQII 312 LI RI +PA RI+ E+ +EWF K A + ++ D+ D E ++ Sbjct: 244 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS--LDDVDAIFDDSGESKNLV 301 Query: 313 AE 314 E Sbjct: 302 VE 303 >4FG9-A nrPDB Length = 320 Score = 297 bits (762), Expect = 4e-81, Method: Composition-based stats. Identities = 95/302 (31%), Positives = 147/302 (48%), Gaps = 6/302 (1%) Query: 5 AVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENV 62 AV GP D Y+ +G+G F L DK++ +LVA+K I + E + ++ Sbjct: 4 AVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSM 63 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + EI ++HPNIV ++ + HL ++M+ SGGELF+RI G ++E +A Sbjct: 64 ENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF 123 Query: 123 QLISGVSYCHAMQVCHRDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 Q++ V Y H + + HRDLK EN L ++ I DFG SK S + GTP Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+APEVL +K Y K D WS GV Y++L G PF D + K F + + ++ P Sbjct: 184 YVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK--AEYEFDSP 240 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQP 301 + IS + I + DP KR + + H W + D +++ Q ++ Sbjct: 241 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 300 Query: 302 GQ 303 + Sbjct: 301 SK 302 >5U6Y-A nrPDB Length = 461 Score = 297 bits (761), Expect = 4e-81, Method: Composition-based stats. Identities = 97/332 (29%), Positives = 159/332 (47%), Gaps = 9/332 (2%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRHPNI 77 Y+L +++G G F V R + + A K I + + + ++RE R L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 VR + I H ++ + +GGELFE I +SE +A QQ++ V +CH M V Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 138 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKEYDG 195 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K Y G Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 180 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 K D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + LI+ Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 256 RIFVADPAKRISIPEIRNHEWFL-KNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAE 314 ++ +P+KRI+ E H W ++ A M+ + + + I+ + Sbjct: 239 KMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLA 298 Query: 315 ATVPPAGTQNLNHYLTGSLDIDDDMEEDLESD 346 G N G + + +E + Sbjct: 299 TRNFSGGKSGGNKKSDGVKESSESTNTTIEDE 330 >2V7O-A nrPDB Length = 336 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 144/282 (51%), Gaps = 8/282 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +++G G F V R K + A K I + + + ++RE R L+H Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I +V + +GGELFE I +SE +A Q++ V++ H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 135 QVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 + HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ K +++ + + P++ ++PE ++ Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--KAGAYDFPSPEWDTVTPEAKN 266 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 LI+++ +PAKRI+ + H W + M T + Sbjct: 267 LINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 308 >3KK8-A nrPDB Length = 284 Score = 296 bits (759), Expect = 8e-81, Method: Composition-based stats. Identities = 86/264 (32%), Positives = 134/264 (50%), Gaps = 7/264 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRH 74 SD Y++ +++G G F V R K + A K I + + + RE R L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I + +V + +GGELFE I +SE +A QQ++ ++YCH+ Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 135 QVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HR+LK EN LL +K+ DFG + GTP Y++PEVL K Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 K D+W+CGV LY++LVG PF D ++ + + + + Y P++ ++PE + L Sbjct: 185 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 241 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 I + +P KRI+ + W Sbjct: 242 IDSMLTVNPKKRITADQALKVPWI 265 >2JC6-A nrPDB Length = 334 Score = 296 bits (759), Expect = 8e-81, Method: Composition-based stats. Identities = 89/286 (31%), Positives = 143/286 (50%), Gaps = 6/286 (2%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPNIV 78 +E + +G+G F L +K + +L AVK I + + + +++ EI R ++H NIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 +++ +P HL +VM+ SGGELF+RI G ++E +A +Q++ V Y H M + H Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 143 Query: 139 RDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 RDLK EN L ++ I DFG SK + GTP Y+APEVL +K Y K Sbjct: 144 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKA 202 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 D WS GV Y++L G PF D + K F + + ++ P + IS + I + Sbjct: 203 VDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK--AEYEFDSPYWDDISDSAKDFIRNL 260 Query: 258 FVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQ 303 DP KR + + H W + + +++ Q ++ + Sbjct: 261 MEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSK 306 >3BHH-A nrPDB Length = 295 Score = 296 bits (759), Expect = 9e-81, Method: Composition-based stats. Identities = 96/282 (34%), Positives = 145/282 (51%), Gaps = 8/282 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 +D Y+L +DIG G F V R + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 NIVR + I +V + +GGELFE I +SE +A QQ++ V +CH M Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 135 QVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 V HRDLK EN LL +K+ DFG + Q GTP Y++PEVL K+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ K +++ + + P++ ++PE ++ Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--KAGAYDFPSPEWDTVTPEAKN 239 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 LI+++ +PAKRI+ E H W + M T + Sbjct: 240 LINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVE 281 >5IG1-A nrPDB Length = 344 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 92/340 (27%), Positives = 155/340 (45%), Gaps = 16/340 (4%) Query: 4 PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--- 60 P + ++D D + IG G F +K++ E+ AVK I Sbjct: 2 PHMETETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEIN 61 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 +KREI SL+H +IV + +H +V EY SGGELF+ I ++E +A Sbjct: 62 KIKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASAC 121 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 Q++S + +CH+ + HRDLK EN LL P +KI DFG + GT Sbjct: 122 MHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGT 181 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 P Y++PEV+ + YD DVW+CGV LY++LVG PF + + K + + + + Sbjct: 182 PGYLSPEVIRRVPYDT-AVDVWACGVILYILLVGYPPFWEEDHQKLYAQI--KNCQYDFP 238 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNTMTTQFDES 298 P++ ++ + LI + +P +R ++ E+ H W +++P + T+ + Sbjct: 239 SPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSVHRQATLEELKKFN 298 Query: 299 DQP--------GQSIEEIMQIIAEATVPPAGTQNLNHYLT 330 + + ++M+ + EAT + L Sbjct: 299 ARRKLKGGVNAVIGVSKMMRTMQEATRALTLSAKSAAALE 338 >2VZ6-A nrPDB Length = 313 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 90/268 (33%), Positives = 142/268 (52%), Gaps = 8/268 (2%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRS 71 ++ Y+L +++G G F V R + + A K I + + + ++RE R Sbjct: 18 LYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL 77 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 L+HPNIVR + I H ++ + +GGELFE I +SE +A QQ++ V +C Sbjct: 78 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 132 HAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLL 189 H M V HRDLK EN LL +K+ DFG + Q GTP Y++PEVL Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 K Y GK D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE Sbjct: 198 KDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPE 254 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWF 277 + LI+++ +P+KRI+ E H W Sbjct: 255 AKDLINKMLTINPSKRITAAEALKHPWI 282 >4D28-A nrPDB Length = 446 Score = 294 bits (753), Expect = 4e-80, Method: Composition-based stats. Identities = 110/282 (39%), Positives = 158/282 (56%), Gaps = 13/282 (4%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHR 70 M +YE+ + IG G F + R+ + + VA+K + + + + +KREI + Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 +RHPNIVR EV+ + + + IV+E+ +GGELF+RI + GR EDE+R +FQQL+ V++ Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLL 189 CH+ V HRDLK EN LLD + LK+ DFG S + T GTP Y+APEVL Sbjct: 125 CHSKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS 182 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 + YDG AD+WSCGV L+V+L G PF + + P +RK I ++ P + S E Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFDCPPW--FSAE 236 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTM 291 + LI RI +P RI I I+ WF KN + Sbjct: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEE 278 >4YZB-A nrPDB Length = 491 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 107/385 (27%), Positives = 169/385 (43%), Gaps = 48/385 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLR 73 SDRY+ + +G G+FG L +DK + + AVK I + + + + +E+ + L Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HPNI++ E + +V E +GGELF+ I + RFSE +A +Q++SG++Y H Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 148 Query: 134 MQVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLK EN LL + ++I DFG S + K +GT YIAPEVL Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG-T 207 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 YD K DVWS GV LY++L G PF E +K + +P + +S + Sbjct: 208 YDEK-CDVWSTGVILYILLSGCPPFNGANEFDILKKVEK--GKFTFDLPQWKKVSEPAKD 264 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD------------- 299 LI ++ P RIS + HEW D D+ + + Sbjct: 265 LIRKMLAYVPTMRISARDALEHEWLK---TTDAATDSIDVPSLESTILNIRQFQGTQKLA 321 Query: 300 -----------QPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDI------------D 336 + E+ +I G + + G +++ Sbjct: 322 AAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQ 381 Query: 337 DDMEEDLESDLDDLDIDSSGEIVYA 361 +E ++E LD +D D +G I Y+ Sbjct: 382 SAIEFEVEQVLDAVDFDKNGFIEYS 406 >5Z33-A nrPDB Length = 425 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 85/396 (21%), Positives = 161/396 (40%), Gaps = 61/396 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLR-H 74 +RY + K++G G +G+ + Q++E VA+K + + + + REI + R H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 75 PNIVRFKEVILTPTHL----AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 NI ++ + + E +L I + ++ + F Q++ G+ Y Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCGLKY 149 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTPAYIAP 185 H+ V HRDLK N L++ LKICDFG ++ + + V T Y AP Sbjct: 150 IHSANVLHRDLKPGNLLVNADC--ELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAP 207 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH-------------- 231 E++L + K DVWS G L +L G F+ + + +H Sbjct: 208 EIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIG 267 Query: 232 ------RILNVQY----AIPD-YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + N+ + P + + +P+ L+ R+ DP+ RIS+ + H + + Sbjct: 268 SPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYL--H 325 Query: 281 LPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEA---------TVPPAGTQNLNH---- 327 + D ++ T F+ + + + E+ ++I + T P AG H Sbjct: 326 IWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEVYRFRQLVRTAPGAGGHGAPHAPQV 385 Query: 328 -----YLTGSLDIDDDMEEDLESDLDDLDIDSSGEI 358 G +D ++ ++DL+ + +G + Sbjct: 386 PIPAGAGQGQWKAEDPRPQEYVGQMNDLEAELAGGL 421 >5YKS-A nrPDB Length = 377 Score = 290 bits (744), Expect = 4e-79, Method: Composition-based stats. Identities = 105/318 (33%), Positives = 168/318 (52%), Gaps = 16/318 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE---NVKREIINHRSLRHPNI 77 Y+L K +G G+F V +L R + E VAVK I++ + ++ +E+ + ++HPNI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 VR EVI T T L +++E GG++F+ I + +ED A+ +F Q++ +SYCH + V Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN + +K+ DFG+S + ++ G+ AY APE+LL EYD Sbjct: 157 VHRDLKPENVVFFEKQ-GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 D+WS GV L++++ G PF++ + +T+ I++ +Y +P H+S EC+ LI+R Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEAND----SETLTMIMDCKYTVP--SHVSKECKDLITR 269 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNT---MTTQFDESDQPGQSIEEIMQIIA 313 + DP +R S+ EI NH W P+ N E + ++ IA Sbjct: 270 MLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIA 329 Query: 314 --EATVPPAGTQNLNHYL 329 +A V T NH Sbjct: 330 DRDAIVEALETNRYNHIT 347 >2JAM-A nrPDB Length = 304 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 88/262 (33%), Positives = 138/262 (52%), Gaps = 6/262 (2%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSLRHPNIVR 79 + ++ +GSG F L++ + + +L A+K I++ D +++ EI + ++H NIV Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVT 70 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 +++ + TH +VM+ SGGELF+RI G ++E +A QQ++S V Y H + HR Sbjct: 71 LEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 130 Query: 140 DLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVA 198 DLK EN L L ++ I DFG SK + + GTP Y+APEVL +K Y K Sbjct: 131 DLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPY-SKAV 188 Query: 199 DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIF 258 D WS GV Y++L G PF + E K F K + ++ P + IS + I + Sbjct: 189 DCWSIGVITYILLCGYPPFYEETESKLFEKI--KEGYYEFESPFWDDISESAKDFICHLL 246 Query: 259 VADPAKRISIPEIRNHEWFLKN 280 DP +R + + +H W N Sbjct: 247 EKDPNERYTCEKALSHPWIDGN 268 >3SOA-A nrPDB Length = 444 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 91/305 (29%), Positives = 153/305 (50%), Gaps = 9/305 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRSLRH 74 ++ Y+L +++G G F V R + + A I + + + ++RE R L+H Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNIVR + I H ++ + +GGELFE I +SE +A QQ++ V +CH M Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 135 QVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKKE 192 V HR+LK EN LL +K+ DFG + Q GTP Y++PEVL K Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y GK D+W+CGV LY++LVG PF D ++ + +++ + + P++ ++PE + Sbjct: 190 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 246 Query: 253 LISRIFVADPAKRISIPEIRNHEWFL-KNLPADLMNDNTMTTQFDESDQPGQSIEEIMQI 311 LI+++ +P+KRI+ E H W ++ A M+ + + + I+ + Sbjct: 247 LINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTV 306 Query: 312 IAEAT 316 + Sbjct: 307 MLATR 311 >3Q5I-A nrPDB Length = 504 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 92/277 (33%), Positives = 137/277 (49%), Gaps = 19/277 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--------------EKIDENVK 63 + Y V+ +GSG +G L ++K + A+K I++ EK E + Sbjct: 35 GESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 EI +SL HPNI++ +V + +V E+ GGELFE+I N +F E +A +Q Sbjct: 95 NEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQ 154 Query: 124 LISGVSYCHAMQVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 ++SG+ Y H + HRD+K EN LL + + +KI DFG S + + +GT Y Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 IAPEVL KK + DVWSCGV +Y++L G PF + +K + D Sbjct: 215 IAPEVLKKK--YNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEK--GKYYFDFND 270 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 + +IS E + LI + D KR + E N W K Sbjct: 271 WKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 >4RGJ-A nrPDB Length = 520 Score = 286 bits (733), Expect = 9e-78, Method: Composition-based stats. Identities = 110/384 (28%), Positives = 177/384 (46%), Gaps = 44/384 (11%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSLR 73 +++Y+ +K +G G+FG L RDK + A+K I + + E++ RE+ + L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NI++ E + +V + +GGELF+ I + RF E +A +Q++SG++Y H Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHK 178 Query: 134 MQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 V HRDLK EN LL +KI DFG S + K +GT YIAP+VL Sbjct: 179 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG- 237 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 YD K D+WSCGV LY++L G PF E +K + +P + IS + + Sbjct: 238 TYDEK-CDIWSCGVILYILLSGCPPFNGSNEYDILKKV--EAGKYTFDLPQFKKISDKAK 294 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT--------TQFDESDQPGQ 303 LI ++ + A RIS + HEW D +N + + QF + + Q Sbjct: 295 DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQ 354 Query: 304 --------------SIEEIMQIIAEATVPPAGTQNLNHYLTG-----SLDIDDD------ 338 +E+ +I + G + N + G L +D Sbjct: 355 AALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGEDTSDLDNA 414 Query: 339 -MEEDLESDLDDLDIDSSGEIVYA 361 +E +++ L+ +D+D +G I Y+ Sbjct: 415 AIEYEVDQILNSIDLDQNGYIEYS 438 >3F3Z-A nrPDB Length = 277 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 97/271 (35%), Positives = 142/271 (52%), Gaps = 10/271 (3%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINHRSLRHPNIVR 79 Y L IG G++G ++ K + A K I + D + K+EI +SL HPNI+R Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIR 70 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 E T + +VME +GGELFER+ + F E +A + ++S V+YCH + V HR Sbjct: 71 LYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHR 130 Query: 140 DLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVA 198 DLK EN L L SP LK+ DFG + ++ VGTP Y++P+VL G Sbjct: 131 DLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYGPEC 188 Query: 199 DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHISPECRHLISR 256 D WS GV +YV+L G PF P + + + +I + P D++++SP+ LI R Sbjct: 189 DEWSAGVMMYVLLCGYPPFSAPTD----SEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 + P +RI+ + HEWF K L + N Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQLSSSPRN 275 >4CQG-A nrPDB Length = 331 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 99/283 (34%), Positives = 150/283 (53%), Gaps = 13/283 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIV 78 YEL + IG+G F +L + E+VA+K +++ + VK EI +SLRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 + V+ T + +V+EY GGELF+ I + R SE+E R F+Q++S V+Y H+ H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAH 130 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 RDLK EN L D + +LK+ DFG + G+ AY APE++ K Y G Sbjct: 131 RDLKPENLLFDEN--HKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGS 188 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 ADVWS G+ LYV++ G PF+D N +I+ +Y +P + +SP L+ + Sbjct: 189 EADVWSMGILLYVLMCGFLPFDD----DNVMALYKKIMRGKYEVPKW--LSPSSILLLQQ 242 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADL-MNDNTMTTQFDES 298 + DP KRIS+ + NH W +++ + T T DE Sbjct: 243 MLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDED 285 >2HAK-A nrPDB Length = 328 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 110/289 (38%), Positives = 159/289 (55%), Gaps = 12/289 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPN 76 Y L K IG GNF +L R + VAVK I++ + +++ RE+ + L HPN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 135 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLDG +KI DFG+S + ++ + G+P Y APE+ K+YDG Sbjct: 136 VHRDLKAENLLLDGDM--NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ + Sbjct: 194 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKK 247 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSI 305 + V +P KR S+ +I W + + T D +D I Sbjct: 248 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDP-DFNDTKRIDI 295 >6C9D-A nrPDB Length = 459 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 110/289 (38%), Positives = 158/289 (54%), Gaps = 12/289 (4%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK---REIINHRSLRHPN 76 Y L K IG GNF +L R + VAVK I++ + +++ RE+ + L HPN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IV+ EVI T L +VMEYASGGE+F+ + GR E EAR F+Q++S V YCH + Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 141 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGK 196 HRDLK EN LLDG +KI DFG+S + ++ G+P Y APE+ K+YDG Sbjct: 142 VHRDLKAENLLLDGDM--NIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGP 199 Query: 197 VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISR 256 DVWS GV LY ++ G+ PF+ +N ++ R+L +Y IP Y +S +C +L+ + Sbjct: 200 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIPFY--MSTDCENLLKK 253 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSI 305 + V +P KR S+ +I W + + T D +D I Sbjct: 254 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDP-DFNDTKRIDI 301 >4D2V-A nrPDB Length = 356 Score = 280 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 98/287 (34%), Positives = 151/287 (52%), Gaps = 18/287 (6%) Query: 14 IMHDSDR----YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--NVKREII 67 M D D YEL + IG+G F +L + E+VA+K +++ + +K EI Sbjct: 20 HMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIE 79 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 ++LRH +I + V+ T + +V+EY GGELF+ I + R SE+E R F+Q++S Sbjct: 80 ALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSA 139 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAP 185 V+Y H+ HRDLK EN L D +LK+ DFG ++ G AY AP Sbjct: 140 VAYVHSQGYAHRDLKPENLLFDE--YHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 E++ K Y G ADVWS G+ LYV++ G PF+D + +I+ +Y +P + Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAA----LVAKIMRGKYDVPKW-- 251 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLK--NLPADLMNDNT 290 +SP L+ ++ DP KRIS+ + NH W ++ N P + + N Sbjct: 252 LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNP 298 >4UZD-A nrPDB Length = 287 Score = 280 bits (717), Expect = 6e-76, Method: Composition-based stats. Identities = 89/284 (31%), Positives = 149/284 (52%), Gaps = 16/284 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK----IDENVKREIINHRSLRH 74 + +E+ + +G G FG L R+KQS ++A+K + + + ++ ++RE+ LRH Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 PNI+R T + +++EYA G ++ + +F E + +L + +SYCH+ Sbjct: 68 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSK 127 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 +V HRD+K EN LL A LKI DFG+S S+ + GT Y+ PE++ + +D Sbjct: 128 RVIHRDIKPENLLLGS--AGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHD 184 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D+WS GV Y LVG PF E +++T RI V++ PD+ ++ R LI Sbjct: 185 EK-VDLWSLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDF--VTEGARDLI 237 Query: 255 SRIFVADPAKRISIPEIRNHEWFLKN--LPADLMNDNTMTTQFD 296 SR+ +P++R + E+ H W N P++ N + + Sbjct: 238 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAAAALE 281 >3D2K-A nrPDB Length = 272 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 86/277 (31%), Positives = 147/277 (53%), Gaps = 14/277 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK----IDENVK 63 GP+ + +++ + +G G FG L R++QS ++A+K + + + ++ ++ Sbjct: 1 GPLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR 60 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 RE+ LRHPNI+R T + +++EYA G ++ + RF E + + Sbjct: 61 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITE 120 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 L + +SYCH+ +V HRD+K EN LL + LKI DFG+S S+ + GT Y+ Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSN--GELKIADFGWS-VHAPSSRRTTLCGTLDYL 177 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 PE++ + +D K D+WS GV Y LVG PF E +++T RI V++ PD+ Sbjct: 178 PPEMIEGRMHDEK-VDLWSLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDF 232 Query: 244 VHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 ++ R LISR+ + ++R+++ E+ H W N Sbjct: 233 --VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKAN 267 >4YNZ-A nrPDB Length = 342 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 103/336 (30%), Positives = 181/336 (53%), Gaps = 14/336 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE---NVKREIINHRSLRHPNI 77 Y L K +G G G+ +L + + VA+K + R + + V+REI + + HP++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 ++ +V +L +V+E+ SGGELF+ + GR + EAR FF+Q+IS + +CH+ +C Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 131 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK EN LLD ++I DFG + V S +++ G+P Y PEV+ ++YDG+ Sbjct: 132 HRDLKPENLLLDE--RNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRI 257 ADVWSCGV L+ +LVGA PF+D N R+ + ++ + +P + I P+C+ L+ + Sbjct: 190 ADVWSCGVILFALLVGALPFDD----DNLRQLLEKVKRGVFHMPHF--IPPDCQSLLRGM 243 Query: 258 FVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 D A+R+++ I+ H W++ + + S+E+I + ++ Sbjct: 244 IEVDAARRLTLEHIQKHIWYIGGKNEP---EPEQPIPRKVQIRSLPSLEDIDPDVLDSMH 300 Query: 318 PPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDID 353 ++ N L L +++ E+ + L D ++ Sbjct: 301 SLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKLE 336 >5XZW-A nrPDB Length = 471 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 81/270 (30%), Positives = 127/270 (47%), Gaps = 16/270 (5%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI--DENVKREIINHRSLRHPNIVRF 80 + + +G G F + ++ + + AVK I + + I + V RE+ + L HP IVR Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRL 259 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRD 140 K +VME+ SGG+L + + G ED R +Q+++ + Y H+M + HRD Sbjct: 260 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 319 Query: 141 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK---------- 190 LK +N L++ +KI DFG +K S K+ GT AY+APEV+ Sbjct: 320 LKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEY 379 Query: 191 --KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + + D+WS G +YV+L G PF + K I R + + D+ IS Sbjct: 380 EERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGRGSYHEGPLKDF-RISE 437 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFL 278 E R I + DP R + + NH W + Sbjct: 438 EARDFIDSLLQVDPNNRSTAAKALNHPWIV 467 >3NYO-A nrPDB Length = 576 Score = 277 bits (708), Expect = 6e-75, Method: Composition-based stats. Identities = 86/354 (24%), Positives = 151/354 (42%), Gaps = 26/354 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPN 76 + + +G G FG + + + ++ A K +E+ E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAM 134 +V T L +V+ +GG+L I + G+ F E A F+ ++ G+ H Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 ++ +RDLK EN LLD ++I D G + K VGT Y+APEV+ + Y Sbjct: 306 RIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 D W+ G LY M+ G PF+ ++ K R+ + R++ + SP+ R L Sbjct: 364 FSP-DWWALGCLLYEMIAGQSPFQQRKK-KIKREEVERLVK-EVPEEYSERFSPQARSLC 420 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 S++ DPA+R+ S E++ H F K L + + F + D ++++ Sbjct: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKK-LNFKRLGAGMLEPPF-KPDPQAIYCKDVL 478 Query: 310 QIIAEATVP-----PAGTQNLNHYLTGSLDI---DDDMEEDLESDLDDLDIDSS 355 I +TV P + TGS+ I ++ +E + +L+ +D S Sbjct: 479 DIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGS 532 >4NIF-A nrPDB Length = 333 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 87/282 (30%), Positives = 142/282 (50%), Gaps = 13/282 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 SD Y + + IG G++ + K +N AVK I++ ++ EI R +HPN Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE---EIEILLRYGQHPN 63 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 I+ K+V H+ +V E GGEL ++I FSE EA F + V Y H+ V Sbjct: 64 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 137 CHRDLKLENTL-LDGSPAPR-LKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEY 193 HRDLK N L +D S P L+ICDFG++K + + T ++APEVL ++ Y Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 183 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHISPECR 251 D + D+WS G+ LY ML G PF + + + RI + ++ + ++ +S + Sbjct: 184 D-EGCDIWSLGILLYTMLAGYTPFANGPSDTP-EEILTRIGSGKFTLSGGNWNTVSETAK 241 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLK--NLPADLMNDNTM 291 L+S++ DP +R++ ++ H W + LP ++ + Sbjct: 242 DLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL 283 >2J90-A nrPDB Length = 304 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 85/270 (31%), Positives = 142/270 (52%), Gaps = 12/270 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-------DENVKREIINHR 70 D YE+ +++GSG F + R R K + + A K+I++ E ++RE+ R Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 +RHPNI+ ++ T + +++E SGGELF+ + +EDEA F +Q++ GV Y Sbjct: 85 EIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHY 144 Query: 131 CHAMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 H+ ++ H DLK EN +L P PR+K+ DFG + ++ K+ GTP ++APE++ Sbjct: 145 LHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIV 204 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + G AD+WS GV Y++L GA PF + + +N + + + S Sbjct: 205 NYEPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNI--SAVNYDFDEEYFSNTSE 261 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + I R+ V DP +R++I + H W Sbjct: 262 LAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >2YCR-A nrPDB Length = 323 Score = 276 bits (707), Expect = 9e-75, Method: Composition-based stats. Identities = 87/300 (29%), Positives = 138/300 (46%), Gaps = 18/300 (6%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---------KIDE 60 M + D Y + K +GSG G +L ++++ + VA+K I + + Sbjct: 1 MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 NV+ EI + L HP I++ K + IV+E GGELF+++ R E + + Sbjct: 61 NVETEIEILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLY 119 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 F Q++ V Y H + HRDLK EN LL +KI DFG+SK S ++ GT Sbjct: 120 FYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGT 179 Query: 180 PAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 P Y+APEVL + + D WS GV L++ L G PF + + + I Sbjct: 180 PTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS-GKYN 238 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF----LKNLPADLMNDNTMTT 293 + + +S + L+ ++ V DP R + E H W +K DL+++ +T Sbjct: 239 FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENEST 298 >1FOT-A nrPDB Length = 318 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 86/293 (29%), Positives = 149/293 (50%), Gaps = 21/293 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHP 75 +++++ +G+G+FG L+R + + A+K +++ + E+ E + + HP Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + ++M+Y GGELF + + RF A+F+ ++ + Y H+ Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKD 126 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + +RDLK EN LLD + +KI DFG++K + GTP YIAPEV+ K Y+ Sbjct: 127 IIYRDLKPENILLDKN--GHIKITDFGFAKYVP--DVTYTLCGTPDYIAPEVVSTKPYN- 181 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 K D WS G+ +Y ML G PF D KT +ILN + P + + + + L+S Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNT----MKTYEKILNAELRFPPF--FNEDVKDLLS 235 Query: 256 RIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQ 303 R+ D ++R+ +++NH WF + + L++ N T ++ Q GQ Sbjct: 236 RLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIE-TPYEPPIQQGQ 287 >5JZN-A nrPDB Length = 280 Score = 275 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 76/264 (28%), Positives = 139/264 (52%), Gaps = 7/264 (2%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN--VKREIINHRSLRHP 75 ++RY++ + IG GNF V + ++ + A+K I++ + + ++ E+ R ++HP Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 NIV E + PT L +VME GG+LF+ I + +++E +A L S + Y H++ Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 136 VCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + HRD+K EN L+ + LK+ DFG + +++ + GTP Y+APE++ + Y Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLA--TIVDGPLYTVCGTPTYVAPEIIAETGY 195 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 G D+W+ GV Y++L G PF + + + V + P + ++S + L Sbjct: 196 -GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 254 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 I+ + + D +R S ++ H W Sbjct: 255 ITMMLLVDVDQRFSAVQVLEHPWV 278 >2BPM-A nrPDB Length = 309 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 79/311 (25%), Positives = 136/311 (43%), Gaps = 33/311 (10%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRS 71 + D + ++ V+ IG G +GV R+K + E+VA+K I E + REI + Sbjct: 3 LVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 62 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVS 129 L HPNIV+ +VI T L +V E+ +L + + + + + QL+ G++ Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVL 188 +CH+ +V HRDLK +N L++ A +K+ DFG +++ V V T Y APE+L Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH--------------RIL 234 L +Y D+WS G M+ F E + + Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 235 NVQYAIPDY---------VHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADL 285 + + + P + + + R L+S++ DP KRIS H +F +++ + Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTKPV 298 Query: 286 MNDNTMTTQFD 296 + D Sbjct: 299 PHLRLERPHRD 309 >3HDN-A nrPDB Length = 373 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 100/338 (29%), Positives = 159/338 (47%), Gaps = 22/338 (6%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREII 67 GP P SD + +K IG G+FG L R K AVK +++ + + ++ I+ Sbjct: 28 GPSSNPHAKPSD-FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 86 Query: 68 -----NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 ++++HP +V T L V++Y +GGELF + F E ARF+ Sbjct: 87 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 146 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPA 181 ++ S + Y H++ + +RDLK EN LLD + + DFG K ++ H+ ST GTP Sbjct: 147 EIASALGYLHSLNIVYRDLKPENILLDSQ--GHIVLTDFGLCKENIEHNSTTSTFCGTPE 204 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+APEVL K+ YD + D W G LY ML G PF + + +++ L ++ Sbjct: 205 YLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK---- 259 Query: 242 DYVHISPECRHLISRIFVADPAKRISIP----EIRNHEWFLKNLPADLMNDNTMTTQFDE 297 +I+ RHL+ + D KR+ EI++H +F DL+N +T F+ Sbjct: 260 --PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKK-ITPPFNP 316 Query: 298 SDQPGQSIEEIMQIIAEATVPPA-GTQNLNHYLTGSLD 334 + + E VP A G + +T S+ Sbjct: 317 NVSGPNDLRHFDPEFTEEPVPNAIGKAPDSVLVTASVK 354 >1NY3-A nrPDB Length = 400 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 93/310 (30%), Positives = 154/310 (49%), Gaps = 16/310 (5%) Query: 19 DRYELV-KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 D Y++ + +G G G + +K++ E A+K + + +RE+ H R+ + P+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPH 116 Query: 77 IVRFKEVILT----PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 E + LI + +P +R++I E NH W +++ +T ++ ++ EE Sbjct: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 Query: 308 IMQIIAEATV 317 + +A V Sbjct: 356 MTSALATMRV 365 >2OZA-A nrPDB Length = 356 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 93/310 (30%), Positives = 154/310 (49%), Gaps = 16/310 (5%) Query: 19 DRYELV-KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 D Y++ + +G G G + +K++ E A+K + + +RE+ H R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPH 72 Query: 77 IVRFKEVILT----PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 193 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 251 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 E + LI + +P +R++I E NH W +++ +T ++ ++ EE Sbjct: 252 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 311 Query: 308 IMQIIAEATV 317 + +A V Sbjct: 312 MTSALATMRV 321 >3GUB-A nrPDB Length = 295 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 88/288 (30%), Positives = 152/288 (52%), Gaps = 12/288 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDENVKREIINHRS 71 D Y+ +++GSG F V + R+K + A K+I++ E+++RE+ + Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 ++HPN++ EV T + ++ E +GGELF+ + +E+EA F +Q+++GV Y Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 132 HAMQVCHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++Q+ H DLK EN LLD + P PR+KI DFG + ++ K+ GTP ++APE++ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVN 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 + G AD+WS GV Y++L GA PF + + +N ++ + + S Sbjct: 191 YEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANV--SAVNYEFEDEYFSNTSAL 247 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDE 297 + I R+ V DP KR++I + H W ++ QF++ Sbjct: 248 AKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAWSHPQFEK 295 >6FDY-U nrPDB Length = 276 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 87/283 (30%), Positives = 146/283 (51%), Gaps = 13/283 (4%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMR-DKQSNELVAVKYIERGEKID---ENV 62 +GP P D + L + +GSG + K + E+VA+K + + EN+ Sbjct: 1 AGPGWGP--PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL 58 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 EI + +RHP+IV+ K+ ++ ++ME+ +GG+L I E AR F Q Sbjct: 59 LTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQ 118 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 QL S + + H + H DLK +N LL P LK+ DFG+++ + G+P Y Sbjct: 119 QLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLY 178 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY-AIP 241 +APE++ +++YD + D+WS GV LY L G PF ++F + +I + + +P Sbjct: 179 MAPEMVCQRQYDAR-VDLWSMGVILYEALFGQPPFAS----RSFSELEEKIRSNRVIELP 233 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPA 283 +S +CR L+ R+ DP++RIS + H W L+++P+ Sbjct: 234 LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >3KA0-A nrPDB Length = 320 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 93/310 (30%), Positives = 153/310 (49%), Gaps = 16/310 (5%) Query: 19 DRYELV-KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 D Y++ + +G G G + +K++ E A+K + + +RE+ H R+ + P+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPH 70 Query: 77 IVRFKEVILT----PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 71 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + H+ TP Y+APEVL Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLG 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 191 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 249 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 E + LI + +P +R++I E NH W +++ +T ++ ++ EE Sbjct: 250 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 309 Query: 308 IMQIIAEATV 317 + +A V Sbjct: 310 MTSALATMRV 319 >1PHK-A nrPDB Length = 298 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 130/287 (45%), Gaps = 20/287 (6%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----------RGEKI 58 P + YE + +G G V R K + + AVK I+ +++ Sbjct: 7 PGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQEL 66 Query: 59 DENVKREIINHRSLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEA 117 E +E+ R + HPNI++ K+ T T +V + GELF+ + SE E Sbjct: 67 REATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKET 126 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 R + L+ + H + + HRDLK EN LLD +K+ DFG+S + + Sbjct: 127 RKIMRALLEVICALHKLNIVHRDLKPENILLDDDM--NIKLTDFGFSCQLDPGEKLREVC 184 Query: 178 GTPAYIAPEVLL-----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 GTP+Y+APE++ GK D+WS GV +Y +L G+ PF ++ R + Sbjct: 185 GTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMS- 243 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 N Q+ P++ S + L+SR V P KR + E H +F + Sbjct: 244 -GNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >5D9K-A nrPDB Length = 330 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 83/291 (28%), Positives = 149/291 (51%), Gaps = 22/291 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQS---NELVAVKYIERGE---KIDENVKREIINHR 70 D ++EL+K +G G+FG L++ +L A+K +++ + K E Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 + HP IV+ T L +++++ GG+LF R+ F+E++ +F+ +L + + Sbjct: 88 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 147 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 189 H++ + +RDLK EN LLD +K+ DFG SK S+ H + S GT Y+APEV+ Sbjct: 148 LHSLGIIYRDLKPENILLDEE--GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 205 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 ++ + + AD WS GV ++ ML G PF+ + ++T+ IL + +P + +SPE Sbjct: 206 RRGH-TQSADWWSFGVLMFEMLTGTLPFQGKDR----KETMTMILKAKLGMPQF--LSPE 258 Query: 250 CRHLISRIFVADPAKRISI-----PEIRNHEWFLKNLPADLMNDNTMTTQF 295 + L+ +F +PA R+ EI+ H +F + + + + F Sbjct: 259 AQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF-STIDWNKLYRREIHPPF 308 >2JDO-A nrPDB Length = 342 Score = 270 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 101/353 (28%), Positives = 166/353 (47%), Gaps = 28/353 (7%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR--- 64 G MD + + ++ +K +G G FG L+R+K + A+K + + I ++ Sbjct: 1 GAMDPKV--TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV 58 Query: 65 -EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 E ++ RHP + K T L VMEYA+GGELF + F+E+ ARF+ + Sbjct: 59 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 118 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAY 182 ++S + Y H+ V +RD+KLEN +LD +KI DFG K + K+ GTP Y Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLDKD--GHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +APEVL +Y G+ D W GV +Y M+ G PF + + + F IL + P Sbjct: 177 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF----ELILMEEIRFPR 231 Query: 243 YVHISPECRHLISRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTT--QF 295 +SPE + L++ + DP +R+ E+ H +FL D++ + Sbjct: 232 --TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQ 289 Query: 296 DESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLD 348 S+ + ++ + PP +L G L++D E+++ D D Sbjct: 290 VTSEVDTRYFDDEFTAQSITITPPDRYDSL-----GLLELDQREEQEMFEDFD 337 >3I6U-A nrPDB Length = 419 Score = 270 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 84/287 (29%), Positives = 134/287 (46%), Gaps = 18/287 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---------KIDENVKREIINH 69 D Y + K +GSG G +L ++++ + VA++ I + + NV+ EI Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 + L HP I++ K + IV+E GGELF+++ R E + +F Q++ V Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 130 YCHAMQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H + HRDLK EN LL +KI DFG+SK S ++ GTP Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 + + D WS GV L++ L G PF + + + I + + + Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS-GKYNFIPEVWAEV 372 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWF----LKNLPADLMNDN 289 S + L+ ++ V DP R + E H W +K DL+++ Sbjct: 373 SEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEE 419 >4JG6-A nrPDB Length = 355 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 90/282 (31%), Positives = 145/282 (51%), Gaps = 11/282 (3%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 +D YE+ +DIG G++ V + K +N AVK I++ ++ D + EI+ R +HPNI Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR-DPTEEIEIL-LRYGQHPNI 91 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + K+V ++ +V E GGEL ++I FSE EA + V Y HA V Sbjct: 92 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 138 HRDLKLENTL-LDGSPAPR-LKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEYD 194 HRDLK N L +D S P ++ICDFG++K + + T ++APEVL ++ YD Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYD 211 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHISPECRH 252 D+WS GV LY ML G PF + + + + RI + ++++ + +S + Sbjct: 212 A-ACDIWSLGVLLYTMLTGYTPFANGPDDTP-EEILARIGSGKFSLSGGYWNSVSDTAKD 269 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLK--NLPADLMNDNTMT 292 L+S++ DP +R++ + H W + LP +N Sbjct: 270 LVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAP 311 >2YAB-A nrPDB Length = 361 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 86/277 (31%), Positives = 144/277 (51%), Gaps = 16/277 (5%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-------DENVKRE 65 D Y++ +++GSG F + + R+K + A K+I++ + E ++RE Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 + R + HPNI+ +V T + +++E SGGELF+ + SE+EA F +Q++ Sbjct: 66 VSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 126 SGVSYCHAMQVCHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 GV+Y H ++ H DLK EN LLD + P P +K+ DFG + + K+ GTP ++ Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFV 185 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD- 242 APE++ + G AD+WS GV Y++L GA PF + ++T+ I V Y + Sbjct: 186 APEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSYDFDEE 240 Query: 243 -YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + S + I ++ V + KR++I E H W Sbjct: 241 FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >3FXW-A nrPDB Length = 336 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 88/322 (27%), Positives = 153/322 (47%), Gaps = 18/322 (5%) Query: 7 SGPMDLPIMHDSDRYELVK-DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKRE 65 GP + +D Y+L K +G G G +++ + A+K + K ++E Sbjct: 17 QGP-EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK----ARQE 71 Query: 66 IINH-RSLRHPNIVRFKEVILT----PTHLAIVMEYASGGELFERICNAGR--FSEDEAR 118 + +H ++ P+IV +V L I+ME GGELF RI G F+E EA Sbjct: 72 VDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAA 131 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTV 177 + + + + + H+ + HRD+K EN L LK+ DFG++K + ++ ++ Sbjct: 132 EIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA-LQTPC 190 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP--EEPKNFRKTIHRILN 235 TP Y+APEVL ++YD K D+WS GV +Y++L G PF + K R+ Sbjct: 191 YTPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 249 Query: 236 VQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQF 295 + P++ +S + + LI + DP +R++I + NH W +++ +T Sbjct: 250 YGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQ 309 Query: 296 DESDQPGQSIEEIMQIIAEATV 317 ++ D + EE+ +A V Sbjct: 310 EDKDHWDEVKEEMTSALATMRV 331 >2Y7J-A nrPDB Length = 365 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 19/275 (6%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---------EKIDENVKREIINHR 70 +Y+ IG G V R + + AVK +E E++ E +RE R Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 71 SL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 + HP+I+ + + + + +V + GELF+ + SE E R + L+ VS Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 188 + HA + HRDLK EN LLD + ++++ DFG+S + + GTP Y+APE+L Sbjct: 215 FLHANNIVHRDLKPENILLDDNM--QIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILK 272 Query: 189 ----LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 GK D+W+CGV L+ +L G+ PF + R + Q++ P++ Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME--GQYQFSSPEWD 330 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 S + LISR+ DP R++ + H +F + Sbjct: 331 DRSSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >3TAC-A nrPDB Length = 361 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 96/360 (26%), Positives = 161/360 (44%), Gaps = 38/360 (10%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE------KIDEN 61 G M + D YEL + IG G F V R ++++ + AVK ++ + E+ Sbjct: 15 GSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTED 74 Query: 62 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGEL-FERICNAG---RFSEDEA 117 +KRE L+HP+IV E + L +V E+ G +L FE + A +SE A Sbjct: 75 LKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVA 134 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQ-PKS 175 + +Q++ + YCH + HRD+K LL +K+ FG + Sbjct: 135 SHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGG 194 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 VGTP ++APEV+ ++ Y GK DVW CGV L+++L G PF +E + I+ Sbjct: 195 RVGTPHFMAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIK 248 Query: 236 VQYAI--PDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 +Y + + HIS + L+ R+ + DPA+RI++ E NH W + Sbjct: 249 GKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE------------RD 296 Query: 294 QFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDID 353 ++ +++E++ + A + A ++ + S D +L D D Sbjct: 297 RYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPP------EELPDFSED 350 >3MV5-A nrPDB Length = 342 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 101/351 (28%), Positives = 157/351 (44%), Gaps = 36/351 (10%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV----K 63 G MD + + +E +K +G G FG L+++K + A+K +++ + ++ Sbjct: 1 GAMDPRV--TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 58 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 E ++ RHP + K T L VMEYA+GGELF + FSED ARF+ + Sbjct: 59 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 118 Query: 124 LISGVSYCHA-MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPA 181 ++S + Y H+ V +RDLKLEN +LD +KI DFG K + K+ GTP Sbjct: 119 IVSALDYLHSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPE 176 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+APEVL +Y G+ D W GV +Y M+ G PF + ++ K IL + P Sbjct: 177 YLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFP 231 Query: 242 DYVHISPECRHLISRIFVADPAKRIS-----IPEIRNHEWF----------LKNLPA--D 284 + PE + L+S + DP +R+ EI H +F K P Sbjct: 232 R--TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 289 Query: 285 LMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDI 335 + T T FDE + I + ++ ++ H+ Sbjct: 290 QVTSETDTRYFDEEFTA--QMITITPPDQDDSMECVDSERRPHFPQFDYSA 338 >3UTO-A nrPDB Length = 573 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 81/274 (29%), Positives = 135/274 (49%), Gaps = 9/274 (3%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK-YIERGEKIDENVKREII 67 P+++ H D Y++ +++G+G FGV + ++ + A K + E E V++EI Sbjct: 147 PVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 206 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLIS 126 LRHP +V + + ++ E+ SGGELFE++ + SEDEA + +Q+ Sbjct: 207 TMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCK 266 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 G+ + H H DLK EN + + LK+ DFG + K T GT + APE Sbjct: 267 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE 326 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YV 244 V K G D+WS GV Y++L G PF +N +T+ + + + + D + Sbjct: 327 VAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGG----ENDDETLRNVKSCDWNMDDSAFS 381 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 IS + + I ++ +ADP R++I + H W Sbjct: 382 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >5KCV-A nrPDB Length = 460 Score = 267 bits (684), Expect = 5e-72, Method: Composition-based stats. Identities = 96/312 (30%), Positives = 144/312 (46%), Gaps = 32/312 (10%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV----KREII 67 + +E +K +G G FG L+++K + A+K +++ + ++ E Sbjct: 155 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 214 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 ++ RHP + K T L VMEYA+GGELF + FSED ARF+ +++S Sbjct: 215 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 274 Query: 128 VSYCHA-MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAP 185 + Y H+ V +RDLKLEN +LD +KI DFG K + K+ GTP Y+AP Sbjct: 275 LDYLHSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 332 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 EVL +Y G+ D W GV +Y M+ G PF + ++ K IL + P Sbjct: 333 EVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPR--T 385 Query: 246 ISPECRHLISRIFVADPAKRIS-----IPEIRNHEWF----------LKNLPA--DLMND 288 + PE + L+S + DP +R+ EI H +F K P + Sbjct: 386 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 445 Query: 289 NTMTTQFDESDQ 300 T T FDE Sbjct: 446 ETDTRYFDEEFT 457 >4PDS-A nrPDB Length = 347 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 79/270 (29%), Positives = 125/270 (46%), Gaps = 16/270 (5%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI--DENVKREIINHRSLRHPNIVRF 80 + + +G G F + ++ + + +VK I + + I + V RE+ + L HP IVR Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRL 94 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRD 140 K +VME+ SGG+L + + G ED R +Q+++ + Y H+M + HRD Sbjct: 95 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 154 Query: 141 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK---------- 190 LK +N L++ +KI FG +K S K+ GT AY+APEV+ Sbjct: 155 LKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEY 214 Query: 191 --KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + + D+WS G +YV+L G PF + K I R + + D+ IS Sbjct: 215 EERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIGRGSYHEGPLKDF-RISE 272 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFL 278 E R I + DP R + + NH W Sbjct: 273 EARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >3IS5-A nrPDB Length = 285 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 82/268 (30%), Positives = 130/268 (48%), Gaps = 12/268 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPN 76 D + + +GSG FG L+ ++ S +K I + + E ++ EI +SL HPN Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPN 81 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERIC----NAGRFSEDEARFFFQQLISGVSYCH 132 I++ EV ++ IVME GGEL ERI SE +Q+++ ++Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 133 AMQVCHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + V H+DLK EN L D SP +KI DFG ++ + GT Y+APEV + Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRD 201 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 D+WS GV +Y +L G PF + +K ++ N ++P+ Sbjct: 202 V--TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRP---LTPQAV 256 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLK 279 L+ ++ DP +R S ++ +HEWF + Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4L42-A nrPDB Length = 346 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 140/295 (47%), Gaps = 23/295 (7%) Query: 13 PIMHDSDRYELVKDIGSGNFGVAR---LMRDKQSNELVAVKYIER-----GEKIDENVKR 64 P + +EL++ +G G +G + + ++ A+K +++ K + K Sbjct: 12 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 71 Query: 65 EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 E ++HP IV T L +++EY SGGELF ++ G F ED A F+ ++ Sbjct: 72 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 131 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYI 183 + + H + +RDLK EN +L+ +K+ DFG K S+ + GT Y+ Sbjct: 132 SMALGHLHQKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYM 189 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 APE+L++ ++ + D WS G +Y ML GA PF +N +KTI +IL + +P Y Sbjct: 190 APEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPPY 244 Query: 244 VHISPECRHLISRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTT 293 ++ E R L+ ++ + A R+ E++ H +F +L+ Sbjct: 245 --LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPP 297 >6CMJ-A nrPDB Length = 321 Score = 265 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 97/295 (32%), Positives = 150/295 (50%), Gaps = 24/295 (8%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID------------ENVKREI 66 D+Y L +IG G++GV +L ++ N A+K + + + I E V +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 67 INHRSLRHPNIVRFKEVILTP--THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 + L HPN+V+ EV+ P HL +V E + G + E + SED+ARF+FQ L Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDL 152 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYI 183 I G+ Y H ++ HRD+K N L+ +KI DFG S + +TVGTPA++ Sbjct: 153 IKGIEYLHYQKIIHRDIKPSNLLVGED--GHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 184 APEVLLKKE--YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 APE L + + GK DVW+ GVTLY + G PF D + +I + P Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERIMCLHSKIKSQALEFP 266 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFD 296 D I+ + + LI+R+ +P RI +PEI+ H W ++ L +++ T + Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVE 321 >4AW2-A nrPDB Length = 437 Score = 265 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 82/339 (24%), Positives = 144/339 (42%), Gaps = 36/339 (10%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSL 72 + +E++K IG G FG +++ K ++++ A+K + + E + + E + Sbjct: 72 HREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG 131 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISGVSYC 131 I +L +VM+Y GG+L + R E+ ARF+ +++ + Sbjct: 132 DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLL 189 H + HRD+K +N L+D + +++ DFG + Q VGTP YI+PE+L Sbjct: 192 HQLHYVHRDIKPDNILMDMN--GHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQ 249 Query: 190 ----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 K G D WS GV +Y ML G PF + + K ++ Q+ Sbjct: 250 AMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPT-QVTD 308 Query: 246 ISPECRHLISRIFVADPAKRI---SIPEIRNHEWF-------LKNLPADLMND---NTMT 292 +S + LI R+ + R+ I + + H +F ++N A + + T T Sbjct: 309 VSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDT 367 Query: 293 TQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTG 331 + FD D ++ +E PP T H+L Sbjct: 368 SNFDVDDDCLKN--------SETMPPPTHTAFSGHHLPF 398 >2A27-A nrPDB Length = 321 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 144/282 (51%), Gaps = 16/282 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDE 60 G D Y++ +++GSG F + + R+K + A K+I++ + E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 ++RE+ R + H N++ +V T + +++E SGGELF+ + SE+EA F Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVG 178 +Q++ GV+Y H ++ H DLK EN LLD + P P +K+ DFG + + K+ G Sbjct: 121 IKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFG 180 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 TP ++APE++ + G AD+WS GV Y++L GA PF + ++T+ I V Y Sbjct: 181 TPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSY 235 Query: 239 AIPD--YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + + S + I ++ V + KR++I E H W Sbjct: 236 DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >1KOA-A nrPDB Length = 491 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 81/274 (29%), Positives = 135/274 (49%), Gaps = 9/274 (3%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK-YIERGEKIDENVKREII 67 P+++ H D Y++ +++G+G FGV + ++ + A K + E E V++EI Sbjct: 41 PVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 100 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLIS 126 LRHP +V + + ++ E+ SGGELFE++ + SEDEA + +Q+ Sbjct: 101 TMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCK 160 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 G+ + H H DLK EN + + LK+ DFG + K T GT + APE Sbjct: 161 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE 220 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YV 244 V K G D+WS GV Y++L G PF +N +T+ + + + + D + Sbjct: 221 VAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGG----ENDDETLRNVKSCDWNMDDSAFS 275 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 IS + + I ++ +ADP R++I + H W Sbjct: 276 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >1ZWS-A nrPDB Length = 288 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 86/282 (30%), Positives = 146/282 (51%), Gaps = 16/282 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK-------IDE 60 G D Y++ +++GSG F + + R+K + A K+I++ + E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 ++RE+ R + H N++ +V T + +++E SGGELF+ + SE+EA F Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF 120 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVG 178 +Q++ GV+Y H ++ H DLK EN LLD + P P +K+ DFG + + K+ G Sbjct: 121 IKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFG 180 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 TP ++APE++ + G AD+WS GV Y++L GA PF + ++T+ I +V Y Sbjct: 181 TPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTK----QETLANITSVSY 235 Query: 239 AIPD--YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + + H S + I ++ V + KR++I E H W Sbjct: 236 DFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >2Z7Q-A nrPDB Length = 321 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 83/291 (28%), Positives = 147/291 (50%), Gaps = 22/291 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDK---QSNELVAVKYIERGE---KIDENVKREIINHR 70 D +EL+K +G G+FG L+R S L A+K +++ + K E Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 + HP +V+ T L +++++ GG+LF R+ F+E++ +F+ +L G+ + Sbjct: 86 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 145 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 189 H++ + +RDLK EN LLD +K+ DFG SK ++ H + S GT Y+APEV+ Sbjct: 146 LHSLGIIYRDLKPENILLDEE--GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 203 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 ++ + AD WS GV ++ ML G+ PF+ + ++T+ IL + +P + +S E Sbjct: 204 RQGHSH-SADWWSYGVLMFEMLTGSLPFQGKDR----KETMTLILKAKLGMPQF--LSTE 256 Query: 250 CRHLISRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQF 295 + L+ +F +PA R+ EI+ H F + + + + F Sbjct: 257 AQSLLRALFKRNPANRLGSGPDGAEEIKRH-VFYSTIDWNKLYRREIKPPF 306 >5N23-A nrPDB Length = 352 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 90/312 (28%), Positives = 159/312 (50%), Gaps = 33/312 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRH 74 D++E ++ +G+G+FG L++ K++ A+K +++ + + E+ E +++ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +V+EYA GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +K+ DFG++K V P + GTP Y+APE++L K Y+ Sbjct: 162 DLIYRDLKPENLLIDQQ--GYIKVADFGFAKR-VKGRTPWTLCGTPEYLAPEIILSKGYN 218 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + +I++ + P H S + + L+ Sbjct: 219 -KAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFP--SHFSSDLKDLL 271 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF---------LKNLPADLMND---NTMTTQFD- 296 + D KR + +I+NH+WF + + A + T+ FD Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 331 Query: 297 -ESDQPGQSIEE 307 E ++ SI E Sbjct: 332 YEEEEIRVSINE 343 >3KN6-A nrPDB Length = 325 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 96/278 (34%), Positives = 148/278 (53%), Gaps = 14/278 (5%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEV 83 K +G G+F + R K+SN+ AVK I + +++ N ++EI + HPNIV+ EV Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK--RMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 H +VME +GGELFERI FSE EA + ++L+S VS+ H + V HRDLK Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 144 ENTLL-DGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKEYDGKVADVW 201 EN L D + +KI DFG+++ +QP K+ T Y APE+L + YD + D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLW 193 Query: 202 SCGVTLYVMLVGAYPFEDPEEP---KNFRKTIHRILNVQYAIPD--YVHISPECRHLISR 256 S GV LY ML G PF+ + + + + +I ++ + ++S E + LI Sbjct: 194 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 253 Query: 257 IFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 + DP KR+ + +R +EW ++ N + T Sbjct: 254 LLTVDPNKRLKMSGLRYNEWLQ---DGSQLSSNPLMTP 288 >2X4F-A nrPDB Length = 373 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 85/286 (29%), Positives = 134/286 (46%), Gaps = 12/286 (4%) Query: 1 MDRPAVSGPMDLPIM-----HDSDRYELVKD--IGSGNFGVARLMRDKQSNELVAVKYIE 53 +D PA P D I+ + Y + K +G G FG + + +A K I+ Sbjct: 64 VDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK 123 Query: 54 -RGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR- 111 RG K E VK EI L H N+++ + + + +VMEY GGELF+RI + Sbjct: 124 TRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYN 183 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 171 +E + F +Q+ G+ + H M + H DLK EN L A ++KI DFG ++ Sbjct: 184 LTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPRE 243 Query: 172 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH 231 + K GTP ++APEV+ ++ D+WS GV Y++L G PF + + + Sbjct: 244 KLKVNFGTPEFLAPEVVNY-DFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL- 301 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 ++ IS E + IS++ + + + RIS E H W Sbjct: 302 -ACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL 346 >3COM-A nrPDB Length = 314 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 122/280 (43%), Gaps = 9/280 (3%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 D + +++++ +G G++G K++ ++VA+K + + E + +EI + Sbjct: 21 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE-IIKEISIMQ 79 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVS 129 P++V++ T L IVMEY G + + I +EDE Q + G+ Sbjct: 80 QCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLE 139 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 188 Y H M+ HRD+K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 140 YLHFMRKIHRDIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 197 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + Y+ VAD+WS G+T M G P+ D + N S Sbjct: 198 QEIGYNC-VADIWSLGITAIEMAEGKPPYADIHPMRAIFMI---PTNPPPTFRKPELWSD 253 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 + + V P +R + ++ H + ++ D Sbjct: 254 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRD 293 >4RLP-A nrPDB Length = 288 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 139/291 (47%), Gaps = 23/291 (7%) Query: 17 DSDRYELVKDIGSGNFGVAR---LMRDKQSNELVAVKYIER-----GEKIDENVKREIIN 68 + +EL++ +G G +G + + ++ A+K +++ K + K E Sbjct: 3 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 62 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 ++HP IV T L +++EY SGGELF ++ G F ED A F+ ++ + Sbjct: 63 LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 122 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEV 187 + H + +RDLK EN +L+ +K+ DFG K S+ + GT Y+APE+ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 L++ ++ + D WS G +Y ML GA PF +N +KTI +IL + +P Y ++ Sbjct: 181 LMRSGHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPPY--LT 233 Query: 248 PECRHLISRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTT 293 E R L+ ++ + A R+ E++ H +F +L+ Sbjct: 234 QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPP 284 >3OHT-A nrPDB Length = 389 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 137/337 (40%), Gaps = 44/337 (13%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHR 70 I +RY+ + +GSG +G D +S +AVK + R + + RE+ + Sbjct: 46 IWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLK 105 Query: 71 SLRHPNIVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 ++H N++ +V T L +V G I + ++D +F Q+ Sbjct: 106 HMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQI 163 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 + G+ Y H+ + HRDLK N ++ LKI DFG ++ + + V T Y A Sbjct: 164 LRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARHT--DDEMTGYVATRWYRA 219 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI-------------- 230 PE++L + D+WS G + +L G F + ++ + Sbjct: 220 PEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRM 279 Query: 231 --HRILNVQYAIPD---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 H N ++P ++ +P L+ ++ V D KRI+ E H +F + Sbjct: 280 PSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQ 339 Query: 280 NLPADLMNDNTMTTQFDESDQPGQ-SIEEIMQIIAEA 315 D D + +D+S + Q IEE ++ E Sbjct: 340 YHDPD---DEPESEPYDQSFESRQLEIEEWKRLTYEE 373 >5FET-A nrPDB Length = 847 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 143/326 (43%), Gaps = 22/326 (6%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----RHP 75 E + IG G FG +L+ K + A+K + + I N + I R + HP Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHP 593 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + E +GGEL++ I G S+ +A+F+ +I + Y H Sbjct: 594 FIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERN 653 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + +RDLK EN LLD +K+ DFG +K + + + VGTP Y+APEV+L K Y G Sbjct: 654 IVYRDLKPENILLDKQ--GYVKLIDFGCAKK--IQGRAYTLVGTPHYMAPEVILGKGY-G 708 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D+W+ GV LY + G PF + +E + + IL Q PDYV + +L+ Sbjct: 709 CTVDIWALGVCLYEFICGPLPFGNDQEDQ--LEIFRDILTGQLTFPDYVS-DQDSINLMK 765 Query: 256 RIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQ 310 R+ P RI +I+ H +F N D + + + +I Q Sbjct: 766 RLLCRLPQGRIGCSINGFKDIKEHAFF-GNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQ 824 Query: 311 IIAEATVPPAGTQNLNHYLTGSLDID 336 I E + + S D+D Sbjct: 825 IEEEDALN----EGEPLDGDDSWDVD 846 >1KOB-A nrPDB Length = 387 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 73/275 (26%), Positives = 133/275 (48%), Gaps = 5/275 (1%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-NVKREII 67 P+++ D Y++++++GSG FGV +K + + K+I +D+ VK EI Sbjct: 41 PVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEIS 100 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLIS 126 L HP ++ + + +++E+ SGGELF+RI + SE E + +Q Sbjct: 101 IMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACE 160 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 G+ + H + H D+K EN + + A +KI DFG + K T T + APE Sbjct: 161 GLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPE 220 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 ++ +E G D+W+ GV YV+L G PF ++ + + + + ++ + + Sbjct: 221 -IVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV--KRCDWEFDEDAFSSV 277 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 SPE + I + +P KR+++ + H W + Sbjct: 278 SPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >4B6L-A nrPDB Length = 281 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 88/278 (31%), Positives = 133/278 (47%), Gaps = 14/278 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPN 76 Y + +G G F D ++ AVK I + E + EI HR L+H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 IVRF ++ I +E S L E E R++ +Q++SG+ Y H + Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 HRDLKL N + + LK+ DFG ++ + K+ GTP Y+APEVLL++ + G Sbjct: 131 LHRDLKLGNFFITENM--ELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-G 187 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 ADVWS G +Y +L G+ PF E + ++T I V Y +P +S R L++ Sbjct: 188 PEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIKQVHYTLP--ASLSLPARQLLA 241 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 I A P R SI +I H++F K D + ++ T Sbjct: 242 AILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVT 279 >5X3F-B nrPDB Length = 393 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 88/312 (28%), Positives = 158/312 (50%), Gaps = 34/312 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRH 74 D+++ +K +G+G+FG L++ K+S A+K +++ + + E+ E +++ Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +VMEY +GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 144 PFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 203 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +++ DFG++K + + GTP Y+APE++L K Y+ Sbjct: 204 DLIYRDLKPENLLIDQQ--GYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYN 259 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + +I++ + P H S + + L+ Sbjct: 260 -KAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFP--SHFSSDLKDLL 312 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF---------LKNLPADLMND---NTMTTQFD- 296 + D KR + +I+NH+WF + + A + T+ FD Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 372 Query: 297 -ESDQPGQSIEE 307 E ++ SI E Sbjct: 373 YEEEEIRVSINE 384 >3NIZ-A nrPDB Length = 311 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 127/301 (42%), Gaps = 33/301 (10%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVK 63 SG +L ++Y+ ++ +G G +GV +D Q +VA+K I E I Sbjct: 9 SGRENLYFQGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAI 67 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQ 122 REI + L HPNIV +VI + L +V E+ +L + + N + + + + Sbjct: 68 REISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLY 126 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPA 181 QL+ GV++CH ++ HRDLK +N L++ A LK+ DFG +++ + V T Sbjct: 127 QLLRGVAHCHQHRILHRDLKPQNLLINSDGA--LKLADFGLARAFGIPVRSYTHEVVTLW 184 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA-I 240 Y AP+VL+ + D+WS G M+ G F + K + Sbjct: 185 YRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREW 244 Query: 241 PDYVHIS-----------------------PECRHLISRIFVADPAKRISIPEIRNHEWF 277 P + E L+S + DP KRIS + NH +F Sbjct: 245 PQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 Query: 278 L 278 Sbjct: 305 K 305 >5DYK-A nrPDB Length = 853 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 89/304 (29%), Positives = 141/304 (46%), Gaps = 18/304 (5%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL---- 72 + D E + IG G FG +L+ K + A+K + + I+ N + I R + Sbjct: 537 EMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEN 596 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 HP I+R + + E +GGEL++ I G S+ +A+F+ +I + Y H Sbjct: 597 DHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLH 656 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 + +RDLK EN LLD +K+ DFG +K + + + VGTP Y+APEV+L K Sbjct: 657 ERNIVYRDLKPENILLDKQ--GYVKLIDFGCAKK--VQGRAYTLVGTPHYMAPEVILGKG 712 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y G D+W+ G+ LY + G PF + EE + + IL Q PDYV + + Sbjct: 713 Y-GCTVDIWALGICLYEFICGPLPFGNDEEDQ--LEIFRDILTGQLTFPDYVTDTDS-IN 768 Query: 253 LISRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 L+ R+ P RI +I++H +F N D + + + + Sbjct: 769 LMKRLLCRLPQGRIGCSINGFKDIKDHPFF-SNFNWDKLAGRLLDPPLVSKSETYAEDID 827 Query: 308 IMQI 311 I QI Sbjct: 828 IKQI 831 >4LG4-A nrPDB Length = 299 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 123/280 (43%), Gaps = 9/280 (3%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 D + +++++ +G G++G K+S ++VA+K + + E + +EI + Sbjct: 3 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-IIKEISIMQ 61 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVS 129 P +V++ T L IVMEY G + + I EDE + + G+ Sbjct: 62 QCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 121 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 188 Y H M+ HR++K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 122 YLHFMRKIHRNIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 179 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + Y+ VAD+WS G+T M G P+ D + N S Sbjct: 180 QEIGYNC-VADIWSLGITSIEMAEGKPPYADIHPMRAIFMI---PTNPPPTFRKPELWSD 235 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 + + + V +P +R + ++ H + P ++ D Sbjct: 236 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRD 275 >4I6B-A nrPDB Length = 308 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 83/281 (29%), Positives = 141/281 (50%), Gaps = 14/281 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----RGEKIDENVKREIINHRSLR 73 RY K +G G F M D +N++ A K I E + +EI HR L Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH 86 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H ++V+F ++ I++EY S + + +E E R++ +Q++SG+ Y H Sbjct: 87 HKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHE 146 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRDLKL N ++ S LK+ DFG ++ L + ++ GTP Y++PEVL K+ Sbjct: 147 QEILHRDLKLGNFFINESM--ELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG 204 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 + G +D+W+ G +Y ML+G PF E N ++T I +Y +P + +H Sbjct: 205 H-GAESDIWALGCVMYTMLLGRPPF----ETTNLKETYRSIREARYTMPSSLLAP--AKH 257 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 LI+ + +P R S+ +I H++F + D ++ + T Sbjct: 258 LIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHT 298 >4WB7-A nrPDB Length = 405 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 88/312 (28%), Positives = 157/312 (50%), Gaps = 34/312 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRH 74 D++E +K +G+G+FG L++ K++ A+K +++ + + E+ E +++ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 215 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + +RDLK EN L+D +++ DFG++K + + GTP Y+APE++L K Y+ Sbjct: 216 DLIYRDLKPENLLIDQQ--GYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYN 271 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K D W+ GV +Y M G PF + + +I++ + P H S + + L+ Sbjct: 272 -KAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFP--SHFSSDLKDLL 324 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWF---------LKNLPADLMND---NTMTTQFD- 296 + D KR + +I+NH+WF + + A + T+ FD Sbjct: 325 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 384 Query: 297 -ESDQPGQSIEE 307 E ++ SI E Sbjct: 385 YEEEEIRVSINE 396 >2HW6-A nrPDB Length = 307 Score = 260 bits (666), Expect = 6e-70, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 123/295 (41%), Gaps = 29/295 (9%) Query: 18 SDRYELV-KDIGSGNFGVARLMRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLR-H 74 D Y+L + +G G + + Q+ + AVK IE+ V RE+ + + Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 NI+ E T +V E GG + I F+E EA + + + + + H Sbjct: 71 KNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK 130 Query: 135 QVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHS--------QPKSTVGTPAYIAP 185 + HRDLK EN L + +KICDF L++ + + G+ Y+AP Sbjct: 131 GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAP 190 Query: 186 EVLL----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK-----------NFRKTI 230 EV+ + + K D+WS GV LY+ML G PF K Sbjct: 191 EVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLF 250 Query: 231 HRILNVQYAIP--DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 I +Y P D+ HIS E + LIS++ V D +R+S ++ H W P Sbjct: 251 ESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPE 305 >4TNB-A nrPDB Length = 590 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 140/354 (39%), Gaps = 26/354 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPN 76 + + +G G FG + + + ++ A K +E+ E + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAM 134 +V T L +V+ +GG+L I N G F E+ A F+ +++ G+ H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 +RDLK EN LLD ++I D G + + VGT Y+APEVL + Y Sbjct: 306 NTVYRDLKPENILLD--DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY- 362 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 G D W G +Y M+ G PF +E + R+L + S E + + Sbjct: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY--SHKFSEEAKSIC 420 Query: 255 SRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 + D +R+ E++ H +F +N+ + + F D ++++ Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFF-RNMNFKRLEAGMLDPPF-VPDPRAVYCKDVL 478 Query: 310 QIIAEATVPP-----AGTQNLNHYLTGSLDI---DDDMEEDLESDLDDLDIDSS 355 I +TV + + TGS+ I ++ +E + +L+ + + Sbjct: 479 DIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGT 532 >3DB8-A nrPDB Length = 317 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 95/296 (32%), Positives = 135/296 (45%), Gaps = 14/296 (4%) Query: 4 PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKID 59 P P L RY + +G G F + D + E+ A K + + Sbjct: 27 PLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQK 86 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 E + EI H+SL +P++V F + +V+E L E +E EAR+ Sbjct: 87 EKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARY 146 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVG 178 F +Q I GV Y H +V HRDLKL N L+ +KI DFG + + K G Sbjct: 147 FMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDM--DVKIGDFGLATKIEFDGERKKDLCG 204 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 TP YIAPEVL KK + + D+WS G LY +LVG PF E ++T RI +Y Sbjct: 205 TPNYIAPEVLCKKGHSFE-VDIWSLGCILYTLLVGKPPF----ETSCLKETYIRIKKNEY 259 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 ++P HI+P LI R+ ADP R S+ E+ E+F + + +T Sbjct: 260 SVPR--HINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVP 313 >4EWQ-A nrPDB Length = 383 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 135/349 (38%), Gaps = 48/349 (13%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHR 70 I +RY+ + +GSG +G D ++ VAVK + R + + RE+ + Sbjct: 40 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 99 Query: 71 SLRHPNIVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 ++H N++ +V L +V G I + ++D +F Q+ Sbjct: 100 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQI 157 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 + G+ Y H+ + HRDLK N ++ LKI DFG ++ + + V T Y A Sbjct: 158 LRGLKYIHSADIIHRDLKPSNLAVNEDC--ELKILDFGLARHT--DDEMTGYVATRWYRA 213 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ------- 237 PE++L + + D+WS G + +L G F + + + + Sbjct: 214 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 273 Query: 238 ------------YAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +P ++ +P L+ ++ V D KRI+ + H +F + Sbjct: 274 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 333 Query: 280 NLPADLMNDNTMTTQFDESDQPGQ-SIEEIMQIIAEA----TVPPAGTQ 323 D D + +D+S + I+E + + PP + Sbjct: 334 YHDPD---DEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQE 379 >6AO5-A nrPDB Length = 362 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 123/280 (43%), Gaps = 9/280 (3%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 D + +++++ +G G++G K+S ++VA+K + + E + +EI + Sbjct: 2 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-IIKEISIMQ 60 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVS 129 P +V++ T L IVMEY G + + I EDE + + G+ Sbjct: 61 QCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 120 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 188 Y H M+ HR++K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 121 YLHFMRKIHRNIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 178 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + Y+ VAD+WS G+T M G P+ D + N S Sbjct: 179 QEIGYNC-VADIWSLGITSIEMAEGKPPYADIHPMRAIFMI---PTNPPPTFRKPELWSD 234 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 + + + V +P +R + ++ H + P ++ D Sbjct: 235 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRD 274 >6E9W-A nrPDB Length = 443 Score = 258 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 145/330 (43%), Gaps = 32/330 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLR 73 ++ YE+VK IG G FG +L+R K + ++ A+K + + E I + E Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 P +V+ +L +VMEY GG+L + N E ARF+ +++ + H+ Sbjct: 161 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHS 219 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLL-- 189 M HRD+K +N LLD S LK+ DFG + + VGTP YI+PEVL Sbjct: 220 MGFIHRDVKPDNMLLDKS--GHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQ 277 Query: 190 -KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 Y G+ D WS GV LY MLVG PF + K ++ PD IS Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH--KNSLTFPDDNDISK 335 Query: 249 ECRHLISRIFVADPAKRI---SIPEIRNHEWFLKNLPA------------DLMNDNTMTT 293 E ++LI D R+ + EI+ H +F + A ++ + T+ Sbjct: 336 EAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTS 394 Query: 294 QFD--ESDQPGQSIEEIMQIIAEATVPPAG 321 FD E D+ + I + +P G Sbjct: 395 NFDDLEEDKGEEETFPIPKAFVGNQLPFVG 424 >4JXF-A nrPDB Length = 266 Score = 258 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 15/268 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRH 74 + +++ +G G+F + VA+K I++ + V+ E+ H L+H Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHA 133 P+I+ ++ +V+E GE+ + N FSE+EAR F Q+I+G+ Y H+ Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 126 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKE 192 + HRDL L N LL + +KI DFG + + H + + GTP YI+PE + + Sbjct: 127 HGILHRDLTLSNLLLTRNM--NIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRS 183 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 G +DVWS G Y +L+G PF+ K + Y +P ++ I E + Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVL----ADYEMPSFLSI--EAKD 237 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKN 280 LI ++ +PA R+S+ + +H + +N Sbjct: 238 LIHQLLRRNPADRLSLSSVLDHPFMSRN 265 >1VZO-A nrPDB Length = 355 Score = 258 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 83/292 (28%), Positives = 139/292 (47%), Gaps = 21/292 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRD---KQSNELVAVKYIERGE-----KIDENVKREIINHR 70 + +EL+K +G+G +G L+R + +L A+K +++ K E+ + E Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 71 SLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 +R P +V T T L ++++Y +GGELF + RF+E E + + +++ + Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEV 187 + H + + +RD+KLEN LLD + + + DFG SK V + GT Y+AP++ Sbjct: 174 HLHKLGIIYRDIKLENILLDSN--GHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDI 231 Query: 188 LLKKE-YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 + + K D WS GV +Y +L GA PF E + + RIL + P + Sbjct: 232 VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ--EM 289 Query: 247 SPECRHLISRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTT 293 S + LI R+ + DP KR+ EI+ H +F K DL Sbjct: 290 SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAP 341 >1CM8-A nrPDB Length = 367 Score = 257 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 135/330 (40%), Gaps = 44/330 (13%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNI 77 Y ++ +GSG +G D ++ VA+K + R E + RE+ + +RH N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 78 VRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + +V T +VM + G ++ + ED +F Q++ G+ Y Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 HA + HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 145 HAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNW 200 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------------HRILN 235 + D+WS G + M+ G F+ + ++ + N Sbjct: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 236 VQYAIPDYV---------HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 +P+ + SP +L+ ++ V D +R++ E H +F Sbjct: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD---T 317 Query: 287 NDNTMTTQFDES-DQPGQSIEEIMQIIAEA 315 D ++D+S D ++++E ++ + Sbjct: 318 EDEPQVQKYDDSFDDVDRTLDEWKRVTYKE 347 >4CSV-A nrPDB Length = 275 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 110/271 (40%), Gaps = 16/271 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREII 67 GP D L + +GSG FG + + N VAVK ++ G E +E Sbjct: 1 GPHD-KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQ 59 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 + L+HPN+V+ V + I+ EY S G L + + C + Q+ Sbjct: 60 IMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVA 119 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---TPAY 182 SG++Y + HRDL N L+ + +K+ DFG ++ + + + G + Sbjct: 120 SGMAYLESQNFIHRDLAARNCLVGENNV--VKVADFGLAR-LINEDEYTARAGAKFPIKW 176 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 APE + + K +DVW+ G+ L+ + G P+ + + + Y +P Sbjct: 177 TAPEAISYNRFSIK-SDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQ-----VERGYRMP 230 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIR 272 E L+ + + P +R + E Sbjct: 231 RPQGCPEEIYELMLQCWNKSPEERPTFAETL 261 >5YV8-A nrPDB Length = 298 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 94/293 (32%), Positives = 143/293 (48%), Gaps = 39/293 (13%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID------------------- 59 ++Y L +IG G++GV +L ++ N A+K + + + I Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 60 --------ENVKREIINHRSLRHPNIVRFKEVILTP--THLAIVMEYASGGELFERICNA 109 E V +EI + L HPN+V+ EV+ P HL +V E + G + E + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 131 Query: 110 GRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV- 168 SED+ARF+FQ LI G+ Y H ++ HRD+K N L+ +KI DFG S Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGED--GHIKIADFGVSNEFKG 189 Query: 169 LHSQPKSTVGTPAYIAPEVLLKKE--YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 + +TVGTPA++APE L + + GK DVW+ GVTLY + G PF D + Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERI 245 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +I + PD I+ + + LI+R+ +P RI +PEI+ H W + Sbjct: 246 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >4QMW-A nrPDB Length = 310 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 74/286 (25%), Positives = 130/286 (45%), Gaps = 20/286 (6%) Query: 3 RPAVSGPMDLPIMHD-----SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RG 55 P SG LP M + + + ++ IG G+FG D ++ ++VA+K I+ Sbjct: 11 SPVQSG---LPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 67 Query: 56 EKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSED 115 E E++++EI P + ++ L T L I+MEY GG + + G E Sbjct: 68 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDET 126 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPK 174 + ++++ G+ Y H+ + HRD+K N LL +K+ DFG + + Sbjct: 127 QIATILREILKGLDYLHSEKKIHRDIKAANVLLSEH--GEVKLADFGVAGQLTDTQIKRN 184 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 + VGTP ++APEV+ + YD K AD+WS G+T + G P + K + I Sbjct: 185 TFVGTPFWMAPEVIKQSAYDSK-ADIWSLGITAIELARGEPPHSELHP----MKVLFLIP 239 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + + S + + +P+ R + E+ H++ L+N Sbjct: 240 KNNPPTLE-GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 284 >6GU6-A nrPDB Length = 302 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 126/289 (43%), Gaps = 33/289 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 + Y ++ IG G +GV R K + ++VA+K I E + REI + LRHP Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICN---AGRFSEDEARFFFQQLISGVSYCH 132 NIV ++V++ + L ++ E+ S +L + + + + + Q++ G+ +CH Sbjct: 67 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKK 191 + +V HRDLK +N L+D +K+ DFG +++ + V T Y +PEVLL Sbjct: 126 SRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 183 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT--------------IHRILNVQ 237 D+WS G + F E + + + + + Sbjct: 184 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 243 Query: 238 YAIPDY---------VHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 P + ++ L+S++ + DPAKRIS NH +F Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >6FD3-A nrPDB Length = 300 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 124/273 (45%), Gaps = 9/273 (3%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHR 70 + + +Y + IG G G D + + VA+K + + + E + EI+ R Sbjct: 15 VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMR 74 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 ++PNIV + + L L +VMEY +GG L + + E + ++ + + + Sbjct: 75 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDF 133 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLL 189 H+ QV HRD+K +N LL + +K+ DFG+ +ST VGTP ++APEV+ Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT 191 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 +K Y G D+WS G+ M+ G P+ + R N + + +S Sbjct: 192 RKAY-GPKVDIWSLGIMAIEMVEGEPPYLNENP---LRALYLIATNGTPELQNPERLSAV 247 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 R ++R D +R S E+ H + + P Sbjct: 248 FRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKP 280 >3TXO-A nrPDB Length = 353 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 90/313 (28%), Positives = 144/313 (46%), Gaps = 25/313 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN------VKREIINHRSL 72 D +E ++ +G G+FG L R K++ +L AVK +++ + ++ ++ I++ Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR- 81 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 HP + + TP L VME+ +GG+L I + RF E ARF+ ++IS + + H Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLKK 191 + +RDLKL+N LLD K+ DFG K + + + GTP YIAPE+L + Sbjct: 142 DKGIIYRDLKLDNVLLDHE--GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 199 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Y G D W+ GV LY ML G PFE E F ILN + P ++H + Sbjct: 200 LY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLF----EAILNDEVVYPTWLH--EDAT 252 Query: 252 HLISRIFVADPAKRISI------PEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSI 305 ++ +P R+ I H +F K + +N + F + + + Sbjct: 253 GILKSFMTKNPTMRLGSLTQGGEHAILRHPFF-KEIDWAQLNHRQIEPPFRPRIKSREDV 311 Query: 306 EEI-MQIIAEATV 317 I E V Sbjct: 312 SNFDPDFIKEEPV 324 >6ED6-A nrPDB Length = 415 Score = 253 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 86/316 (27%), Positives = 136/316 (43%), Gaps = 30/316 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLR 73 ++ Y++VK IG G FG +L+R K S ++ A+K + + E I + E Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 146 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 P +V+ +L +VMEY GG+L + N E A+F+ +++ + H+ Sbjct: 147 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHS 205 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLL-- 189 M + HRD+K +N LLD LK+ DFG + VGTP YI+PEVL Sbjct: 206 MGLIHRDVKPDNMLLDKH--GHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 263 Query: 190 -KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + G+ D WS GV LY MLVG PF + K + P+ IS Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDH--KNSLCFPEDAEISK 321 Query: 249 ECRHLISRIFVADPAKRI---SIPEIRNHEWFLKNLP------------ADLMNDNTMTT 293 ++LI D R+ + EIR H +F + ++ + ++ Sbjct: 322 HAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSS 380 Query: 294 QFDESDQPGQSIEEIM 309 FD+ + +E Sbjct: 381 NFDDIEDDKGDVETFP 396 >3ORZ-A nrPDB Length = 316 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 83/285 (29%), Positives = 132/285 (46%), Gaps = 22/285 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRH 74 + ++ K +G G+F L R+ ++ A+K +E+ I EN V RE L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P V+ L + YA GEL + I G F E RF+ +++S + Y H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLKK 191 + HRDLK EN LL+ ++I DFG +K S+ S VGT Y++PE LL + Sbjct: 157 GIIHRDLKPENILLNEDM--HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTE 213 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 + K +D+W+ G +Y ++ G PF E F+K I+ ++Y P+ P+ R Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQK----IIKLEYDFPE--KFFPKAR 267 Query: 252 HLISRIFVADPAKRISIPE------IRNHEWFLKNLPADLMNDNT 290 L+ ++ V D KR+ E ++ H +F +L Sbjct: 268 DLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP 312 >6DTL-A nrPDB Length = 364 Score = 253 bits (647), Expect = 9e-68, Method: Composition-based stats. Identities = 80/323 (24%), Positives = 128/323 (39%), Gaps = 38/323 (11%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKID---ENVKREIINHRSLRHPNIVRFKE 82 IG G +G+ + ++NE VA+K I + REI R + H NIV ++ Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 83 VILTP-----THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 +I P + I E +L + I + SE+ ++F Q++ G+ Y H+ V Sbjct: 97 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 155 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK N LL+ + LKICDFG ++ + V T Y APE+LL Sbjct: 156 HRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 213 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA---------------IPD 242 DVWS G ++ F + R + I +P Sbjct: 214 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 273 Query: 243 YVHIS---------PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTT 293 Y S P LI ++ DP +RI++ + H + D+ ++ T Sbjct: 274 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH--DISDEPECTI 331 Query: 294 QFDESDQPGQSIEE-IMQIIAEA 315 F+ + EE + ++I Sbjct: 332 PFNFDFENHALSEEQMKELIYRE 354 >5O2C-A nrPDB Length = 380 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 144/334 (43%), Gaps = 31/334 (9%) Query: 26 DIGSGNFGVARLMRDKQSNELVAV-----KYIERGEKIDENVKREIINHRSLRHPNIVRF 80 ++G G F D ++ VA + + + E+ + K E + L+HPNIVRF Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ--QRFKEEAEMLKGLQHPNIVRF 89 Query: 81 KEVILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 + + + +V E + G L + R + +Q++ G+ + H Sbjct: 90 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + +E+ Sbjct: 150 PIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE--MYEEHY 205 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEE-PKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 + DV++ G+ + M YP+ + + + +RK I + PE + + Sbjct: 206 DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN----KVTDPEVKEI 261 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIA 313 I + ++R+SI ++ NH +F D + + E D S +++ Sbjct: 262 IEGCIRQNKSERLSIRDLLNHAFF--------AEDTGLRVELAEEDDCSNS-SLALRLWV 312 Query: 314 EATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDL 347 E G N + S +++ D E++ ++ Sbjct: 313 EDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEM 346 >3DAK-A nrPDB Length = 290 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 79/289 (27%), Positives = 123/289 (42%), Gaps = 22/289 (7%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIIN 68 LP + D YEL + IGSG V + E VA+K I + + + + +EI Sbjct: 2 ALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQA 61 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--------CNAGRFSEDEARFF 120 HPNIV + + L +VM+ SGG + + I +G E Sbjct: 62 MSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ------PK 174 ++++ G+ Y H HRD+K N LL + ++I DFG S K Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGS--VQIADFGVSAFLATGGDITRNKVRK 179 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR-I 233 + VGTP ++APEV+ + AD+WS G+T + GA P+ K T+ Sbjct: 180 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 239 Query: 234 LNVQYAIPD---YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +++ + D R +IS DP KR + E+ H++F K Sbjct: 240 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >4AGU-A nrPDB Length = 311 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 121/288 (42%), Gaps = 31/288 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK---IDENVKREIINHRSLRHP 75 ++YE + IG G++GV R++ + ++VA+K E I + REI + L+HP Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N+V EV L +V EY L E E + Q + V++CH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHN 122 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYIAPEVLLKKEYD 194 HRD+K EN L+ + +K+CDFG+++ V T Y +PE+L+ Sbjct: 123 CIHRDVKPENILI--TKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF---RKTIHRILNVQ------------YA 239 G DVW+ G +L G + + RKT+ ++ Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 240 IPD----------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 IPD + +IS L+ DP +R++ ++ +H +F Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >4FIE-A nrPDB Length = 423 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 79/260 (30%), Positives = 132/260 (50%), Gaps = 9/260 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 217 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L +VME+ GG L + I R +E++ ++ +S HA V HRD+K + Sbjct: 218 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 276 Query: 145 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 277 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 333 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ E P K I N+ + + +SP + + R+ V DPA Sbjct: 334 GIMVIEMVDGEPPYF-NEPPLKAMKMIR--DNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 390 Query: 264 KRISIPEIRNHEWFLKNLPA 283 +R + E+ H + K P Sbjct: 391 QRATAAELLKHPFLAKAGPP 410 >4B8L-A nrPDB Length = 286 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 85/273 (31%), Positives = 137/273 (50%), Gaps = 14/273 (5%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE----NVKREII 67 D +++ + +G G FG L R+KQ+ ++A+K + + + E ++REI Sbjct: 8 PKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIE 67 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 LRHPNI+R + +++E+A GEL++ + GRF E + F ++L Sbjct: 68 IQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADA 127 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + YCH +V HRD+K EN L+ LKI DFG+S + ++ GT Y+ PE+ Sbjct: 128 LHYCHERKVIHRDIKPENLLMGYK--GELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEM 184 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + K +D K D+W GV Y LVG PF+ P + R RI+NV P + +S Sbjct: 185 IEGKTHDEK-VDLWCAGVLCYEFLVGMPPFDSPSHTETHR----RIVNVDLKFPPF--LS 237 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + LIS++ P +R+ + + H W N Sbjct: 238 DGSKDLISKLLRYHPPQRLPLKGVMEHPWVKAN 270 >2OU7-A nrPDB Length = 335 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 88/273 (32%), Positives = 127/273 (46%), Gaps = 14/273 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPNIVRFKE 82 +G G F + D + E+ A K + + E + EI HRSL H ++V F Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + +V+E L E +E EAR++ +Q++ G Y H +V HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKEYDGKVADVW 201 L N L+ +KI DFG + + K GTP YIAPEVL KK + + DVW Sbjct: 169 LGNLFLNEDL--EVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VDVW 225 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 S G +Y +LVG PF E ++T RI +Y+IP HI+P LI ++ D Sbjct: 226 SIGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIP--KHINPVAASLIQKMLQTD 279 Query: 262 PAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 P R +I E+ N E+F + +T Sbjct: 280 PTARPTINELLNDEFFTSGYIPARLPITCLTIP 312 >4AU8-A nrPDB Length = 296 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 134/295 (45%), Gaps = 32/295 (10%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRH 74 S +YE ++ IG G +G ++++++E+VA+K + + E + + REI + L+H Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHA 133 NIVR +V+ + L +V E+ +L + + G + + F QL+ G+ +CH+ Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKE 192 V HRDLK +N L++ + LK+ DFG +++ + + V T Y P+VL + Sbjct: 124 RNVLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA--------IPDY- 243 D+WS G + P + + K I R+L +PDY Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 244 -----------VHISPEC----RHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 V++ P+ R L+ + +P +RIS E H +F P Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >3TKU-A nrPDB Length = 433 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 83/339 (24%), Positives = 141/339 (41%), Gaps = 36/339 (10%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSL 72 + +E++K IG G FG +++ K + + A+K + + E + + E + Sbjct: 88 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 147 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISGVSYC 131 I HL +VM+Y GG+L + + ED ARF+ +++ + Sbjct: 148 DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 207 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLL 189 H + HRD+K +N LLD + +++ DFG Q VGTP YI+PE+L Sbjct: 208 HQLHYVHRDIKPDNVLLDVN--GHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQ 265 Query: 190 ----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 G D WS GV +Y ML G PF + + K ++ Q+ Sbjct: 266 AMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPS-HVTD 324 Query: 246 ISPECRHLISRIFVADPAKRI---SIPEIRNHEWF-------LKNLPADLMND---NTMT 292 +S E + LI R+ + +R+ I + + H +F ++NL A + D + T Sbjct: 325 VSEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDT 383 Query: 293 TQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTG 331 + FD D ++ E P + T +L Sbjct: 384 SNFDVDDDVLRN--------TEILPPGSHTGFSGLHLPF 414 >4JDH-A nrPDB Length = 346 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 79/260 (30%), Positives = 132/260 (50%), Gaps = 9/260 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 140 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L +VME+ GG L + I R +E++ ++ +S HA V HRD+K + Sbjct: 141 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 199 Query: 145 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 200 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 256 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ E P K I N+ + + +SP + + R+ V DPA Sbjct: 257 GIMVIEMVDGEPPYF-NEPPLKAMKMIR--DNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 313 Query: 264 KRISIPEIRNHEWFLKNLPA 283 +R + E+ H + K P Sbjct: 314 QRATAAELLKHPFLAKAGPP 333 >2Q0N-A nrPDB Length = 301 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 79/260 (30%), Positives = 132/260 (50%), Gaps = 9/260 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 95 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L +VME+ GG L + I R +E++ ++ +S HA V HRD+K + Sbjct: 96 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 154 Query: 145 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 155 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 211 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ E P K I N+ + + +SP + + R+ V DPA Sbjct: 212 GIMVIEMVDGEPPYF-NEPPLKAMKMIR--DNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 268 Query: 264 KRISIPEIRNHEWFLKNLPA 283 +R + E+ H + K P Sbjct: 269 QRATAAELLKHPFLAKAGPP 288 >5F9E-A nrPDB Length = 353 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 94/307 (30%), Positives = 154/307 (50%), Gaps = 23/307 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLR---- 73 + +EL K +G G+FG L K++N+ A+K +++ +D++V+ ++ R L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 HP + T +L VMEY +GG+L I + +F A F+ ++I G+ + H+ Sbjct: 79 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHS 138 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLKKE 192 + +RDLKL+N LLD +KI DFG K ++L + GTP YIAPE+LL ++ Sbjct: 139 KGIVYRDLKLDNILLDKD--GHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y+ D WS GV LY ML+G PF +E + F H I P ++ E + Sbjct: 197 YNH-SVDWWSFGVLLYEMLIGQSPFHGQDEEELF----HSIRMDNPFYPRWLE--KEAKD 249 Query: 253 LISRIFVADPAKRISIP-EIRNHEWFLKNLPADLMNDNTMTT-------QFDESDQPGQS 304 L+ ++FV +P KR+ + +IR H F + +L FD S+ + Sbjct: 250 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 309 Query: 305 IEEIMQI 311 + E ++ Sbjct: 310 LNEKPRL 316 >4J52-A nrPDB Length = 293 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 88/273 (32%), Positives = 127/273 (46%), Gaps = 14/273 (5%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPNIVRFKE 82 +G G F + D + E+ A K + + E + EI HRSL H ++V F Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + +V+E L E +E EAR++ +Q++ G Y H +V HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKEYDGKVADVW 201 L N L+ +KI DFG + + K GTP YIAPEVL KK + + DVW Sbjct: 142 LGNLFLNEDL--EVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VDVW 198 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVAD 261 S G +Y +LVG PF E ++T RI +Y+IP HI+P LI ++ D Sbjct: 199 SIGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIP--KHINPVAASLIQKMLQTD 252 Query: 262 PAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 P R +I E+ N E+F + +T Sbjct: 253 PTARPTINELLNDEFFTSGYIPARLPITCLTIP 285 >4XBR-A nrPDB Length = 366 Score = 250 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 79/260 (30%), Positives = 132/260 (50%), Gaps = 9/260 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ + + S +LVAVK ++ R ++ E + E++ R +H N+V Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 160 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L +VME+ GG L + I R +E++ ++ +S HA V HRD+K + Sbjct: 161 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 219 Query: 145 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ + Y G D+WS Sbjct: 220 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 276 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ E P K I N+ + + +SP + + R+ V DPA Sbjct: 277 GIMVIEMVDGEPPYF-NEPPLKAMKMIR--DNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 333 Query: 264 KRISIPEIRNHEWFLKNLPA 283 +R + E+ H + K P Sbjct: 334 QRATAAELLKHPFLAKAGPP 353 >3HKO-A nrPDB Length = 345 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 133/314 (42%), Gaps = 54/314 (17%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE------KIDENVKREIINHRS 71 +Y L IG G++GV R+ + Q+ + A+K + + + K E +K E+ + Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI------------------------- 106 L HPNI R EV ++ +VME GG L +++ Sbjct: 85 LHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPE 144 Query: 107 CNAGRFS---------------EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGS 151 CN + E +Q+ S + Y H +CHRD+K EN L + Sbjct: 145 CNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTN 204 Query: 152 PAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAYIAPEVLL-KKEYDGKVADVWSCGV 205 + +K+ DFG SK + + GTP ++APEVL E G D WS GV Sbjct: 205 KSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGV 264 Query: 206 TLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 L+++L+GA PF + + +++ + + P+Y +SP R L+S + + +R Sbjct: 265 LLHLLLMGAVPFPGVNDADTISQVLNK--KLCFENPNYNVLSPLARDLLSNLLNRNVDER 322 Query: 266 ISIPEIRNHEWFLK 279 H W + Sbjct: 323 FDAMRALQHPWISQ 336 >4KRC-A nrPDB Length = 317 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 127/304 (41%), Gaps = 40/304 (13%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK--YIERGEKIDENVKREIINHRSL 72 M S +++ ++ +G+G + +K + VA+K ++ E REI + L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA------GRFSEDEARFFFQQLIS 126 +H NIVR +VI T L +V E+ +L + + + + ++F QL+ Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAP 185 G+++CH ++ HRDLK +N L+ + +LK+ DFG +++ + + S V T Y AP Sbjct: 120 GLAFCHENKILHRDLKPQNLLI--NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 +VL+ D+WSCG L M+ G F + + + + ++ V Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 246 ISPE----------------------------CRHLISRIFVADPAKRISIPEIRNHEWF 277 P+ + + +P R+S + +H WF Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Query: 278 LKNL 281 + Sbjct: 298 AEYY 301 >2F57-A nrPDB Length = 317 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 72/263 (27%), Positives = 129/263 (49%), Gaps = 9/263 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ + +K + + VAVK ++ R ++ E + E++ R H N+V Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 111 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L +VME+ GG L + I R +E++ ++ +SY H V HRD+K + Sbjct: 112 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 170 Query: 145 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ ++ S + KS VGTP ++APEV+ + Y G D+WS Sbjct: 171 SILLTSD--GRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSL 227 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ + + R+ ++ + D +S R + + V +P+ Sbjct: 228 GIMVIEMIDGEPPYFNEPPLQAMRRIRD---SLPPRVKDLHKVSSVLRGFLDLMLVREPS 284 Query: 264 KRISIPEIRNHEWFLKNLPADLM 286 +R + E+ H + P + Sbjct: 285 QRATAQELLGHPFLKLAGPPSCI 307 >2BRG-A nrPDB Length = 297 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 90/268 (33%), Positives = 146/268 (54%), Gaps = 10/268 (3%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPN 76 + ++LV+ +G G +G +L ++ + E VAVK ++ +D EN+K+EI ++ L H N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V+F + +EY SGGELF+RI E +A+ FF QL++GV Y H + + Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLKKEY 193 HRD+K EN LLD LKI DFG + +++ + GT Y+APE+L ++E+ Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 + DVWSCG+ L ML G P++ P + + + + + I L Sbjct: 185 HAEPVDVWSCGIVLTAMLAGELPWDQPSDSC---QEYSDWKEKKTYLNPWKKIDSAPLAL 241 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNL 281 + +I V +P+ RI+IP+I+ W+ K L Sbjct: 242 LHKILVENPSARITIPDIKKDRWYNKPL 269 >4C0T-A nrPDB Length = 974 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 87/324 (26%), Positives = 146/324 (45%), Gaps = 28/324 (8%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 I + ++ K++G G++ L DK + + AVK +++ I E + + + Sbjct: 261 IRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHAL 320 Query: 74 HP-----NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 + ++ L V++YAS GEL I +E+ R F Q++ + Sbjct: 321 NRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAI 380 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVG 178 Y H V HRDLK EN LLD R++I DFG ++ + + KS VG Sbjct: 381 KYMHDNGVIHRDLKPENILLDDKM--RIQITDFGTARLLEKKNDESEEYPVDVRAKSFVG 438 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 T Y++PE LL+ +Y GK DVW+ G +Y M+ G PF+ E F+K I +Q+ Sbjct: 439 TAEYVSPE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQK----ITKLQF 493 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL----KNLPADLMNDNTMTTQ 294 A R LI +I V P++R +IPEI+ H +F K+ + ++D Sbjct: 494 AF--SAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGP 551 Query: 295 FDESDQPGQSIEEIMQIIAEATVP 318 + + + + E+ + + Sbjct: 552 YKMTAKSMMKVPELNKAPITTVIK 575 >3A8W-A nrPDB Length = 345 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 145/305 (47%), Gaps = 26/305 (8%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-----GEKIDENV 62 G MD + D ++L++ IG G++ L+R K+++ + A+K +++ E ID Sbjct: 1 GAMDPLGLQD---FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 57 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + + ++ HP +V T + L V+EY +GG+L + + E+ ARF+ Sbjct: 58 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 117 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPA 181 ++ ++Y H + +RDLKL+N LLD +K+ D+G K + + GTP Sbjct: 118 EISLALNYLHERGIIYRDLKLDNVLLDSE--GHIKLTDYGMCKEGLRPGDTTSTFCGTPN 175 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE-----DPEEPKNFRKTIHRILNV 236 YIAPE+L ++Y G D W+ GV ++ M+ G PF+ D + IL Sbjct: 176 YIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 234 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKRI------SIPEIRNHEWFLKNLPADLMNDNT 290 Q IP +S + ++ DP +R+ +I+ H +F +N+ D+M Sbjct: 235 QIRIPR--SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF-RNVDWDMMEQKQ 291 Query: 291 MTTQF 295 + F Sbjct: 292 VVPPF 296 >5AWM-A nrPDB Length = 394 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 79/346 (22%), Positives = 135/346 (39%), Gaps = 58/346 (16%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRSLRHP 75 RY ++ IGSG G+ D + + VA+K + R + + RE + + H Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 76 NIVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDE--ARFFFQQLISG 127 NI+ +L +VME +C + D + Q++ G Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCG 158 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + + H+ + HRDLK N ++ LKI DFG ++++ V T Y APEV Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 216 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI------- 240 +L Y + D+WS G + M+ G F + + K I ++ + Sbjct: 217 ILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 275 Query: 241 --------PDYVHIS----------------------PECRHLISRIFVADPAKRISIPE 270 P Y S + R+L+S++ V DP +RIS+ E Sbjct: 276 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 335 Query: 271 IRNHEWFLKNLPADLMNDNTMTTQFDES-DQPGQSIEEIMQIIAEA 315 HE+ A+ + D +D S D+ ++E+ ++I E Sbjct: 336 ALKHEYINVWYDAEEV-DAPAPEPYDHSVDEREHTVEQWKELIYEE 380 >1V0B-A nrPDB Length = 288 Score = 248 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 81/291 (27%), Positives = 129/291 (44%), Gaps = 34/291 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 ++Y ++ IG G +GV ++ E A+K I + E I REI + L+H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHAM 134 NIV+ +VI T L +V E+ +L + + G A+ F QL++G++YCH Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLD-QDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEY 193 +V HRDLK +N L++ LKI DFG +++ + + V T Y AP+VL+ + Sbjct: 120 RVLHRDLKPQNLLINRE--GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY--------AIPDYV- 244 D+WS G M+ GA F E + I RIL +P Y Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMR-IFRILGTPNSKNWPNVTELPKYDP 236 Query: 245 ---------------HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + L+S++ DP +RI+ + H +F +N Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4MYG-A nrPDB Length = 372 Score = 248 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 140/327 (42%), Gaps = 44/327 (13%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNIVRFKEV 83 +GSG +G DK+S E VA+K + R E + RE++ + ++H N++ +V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 84 ILTPTHL------AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + L +VM + +L + + FSE++ ++ Q++ G+ Y H+ V Sbjct: 111 FTPASSLRNFYDFYLVMPFMQ-TDLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVV 167 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 168 HRDLKPGNLAVNEDC--ELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH--RILNVQY--------------AIP 241 D+WS G + ML G F+ + + + + ++ ++P Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 283 Query: 242 D---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT 292 + SP+ L+ ++ D KR++ + H +F + + Sbjct: 284 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE--EETEAQ 341 Query: 293 TQFDES-DQPGQSIEEIMQIIAEATVP 318 FD+S + +++E Q I + V Sbjct: 342 QPFDDSLEHEKLTVDEWKQHIYKEIVN 368 >4KS7-A nrPDB Length = 292 Score = 248 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 73/257 (28%), Positives = 131/257 (50%), Gaps = 9/257 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 IG G+ G+ L R+K S VAVK ++ R ++ E + E++ R +H N+V + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY 89 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 L L ++ME+ GG L + I + R +E++ + ++ ++Y HA V HRD+K + Sbjct: 90 LVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 148 Query: 145 NTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 + LL R+K+ DFG+ + KS VGTP ++APEV+ + Y + D+WS Sbjct: 149 SILLTLD--GRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATE-VDIWSL 205 Query: 204 GVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPA 263 G+ + M+ G P+ + ++ + + + +SP R + R+ V DP Sbjct: 206 GIMVIEMVDGEPPYFSDSPVQAMKRLRD---SPPPKLKNSHKVSPVLRDFLERMLVRDPQ 262 Query: 264 KRISIPEIRNHEWFLKN 280 +R + E+ +H + L+ Sbjct: 263 ERATAQELLDHPFLLQT 279 >4QNY-A nrPDB Length = 354 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 140/345 (40%), Gaps = 41/345 (11%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRD-KQSNELVAVKYIERG----EKIDENVKR 64 + + DRY L + IG+G++GV RD K N LVA+K + + + + + R Sbjct: 11 LQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILR 70 Query: 65 EIINHRSLRHPNIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARF 119 EI NI+ + ++ H IVM+ +L + + + +E +F Sbjct: 71 EIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQF 129 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 F Q + + H+ V HRD+ N L++ + LKICDFG +K + + T Sbjct: 130 FIYQALRALHIIHSAGVIHRDITPANILVNTNC--DLKICDFGLAKEENDQGEYMTDYVT 187 Query: 180 -PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI-------- 230 Y APE++++ + DVW G L +L F+ + K + Sbjct: 188 MRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSE 247 Query: 231 -----------HRILNVQYAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRN 273 + L + P Y SPE L+ + V +P +RI++ + Sbjct: 248 EDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMR 307 Query: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVP 318 H + + D +DN F + ++I ++ + I E +V Sbjct: 308 HPFLEQLH--DDADDNLSYALFRFDENEQKTIVDVKRAIYEESVK 350 >4IC8-A nrPDB Length = 442 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 79/378 (20%), Positives = 143/378 (37%), Gaps = 49/378 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRSLRH 74 D YE+++ IG+G +GV R + + + VA+K I + + RE+ + +H Sbjct: 54 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH 113 Query: 75 PNIVRFKEVIL------TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 NI+ K+++ + +V++ +L + I ++ + + R+F QL+ G+ Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAYI 183 Y H+ QV HRDLK N L++ + LKI DFG ++ V T Y Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENC--ELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI------------- 230 APE++L + D+WS G ML F + + Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 231 -------HRILNVQYAIP-DYVHISP----ECRHLISRIFVADPAKRISIPEIRNHEWFL 278 I ++ P + + P + L+ R+ +P+ RIS H + Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 279 KNLPADLMNDNTMTTQFDE-SDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDD 337 K D ++ FD D+ + E I + I + + Sbjct: 351 KYHDPD--DEPDCAPPFDFAFDREALTRERIKEAIVAE---IEDFHARREGIRQQIRFQP 405 Query: 338 DM-EEDLESDLDDLDIDS 354 + E D+++ S Sbjct: 406 SLQPVASEPGCPDVEMPS 423 >4FZF-B nrPDB Length = 283 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 71/276 (25%), Positives = 124/276 (44%), Gaps = 16/276 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKRE 65 G M P + + ++ IG G+FG D ++ ++VA+K I+ E E++++E Sbjct: 1 GAMADP----EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 56 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 I + ++ L + L I+MEY GG + + AG F E + ++++ Sbjct: 57 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEIL 115 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIA 184 G+ Y H+ + HRD+K N LL +K+ FG + + + VGTP ++A Sbjct: 116 KGLDYLHSEKKIHRDIKAANVLLSEQ--GDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMA 173 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PEV+ + YD K AD+WS G+T + G P D + + I Sbjct: 174 PEVIQQSAYDSK-ADIWSLGITAIELAKGEPPNSDMHP----MRVLFLIPKNNPPT-LVG 227 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + + I DP+ R + E+ H++ +KN Sbjct: 228 DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKN 263 >4BBM-A nrPDB Length = 331 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 31/300 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 ++YE + +G G++G+ R+K + +VA+K + + + + REI + LRH Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 N+V EV +V E+ L + + + Q+I+G+ +CH+ Sbjct: 85 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHN 144 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRD+K EN L+ S +K+CDFG++++ V T Y APE+L+ Sbjct: 145 IIHRDIKPENILVSQSGV--VKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKY 202 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH----------------------- 231 GK DVW+ G + M +G F + + Sbjct: 203 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 262 Query: 232 --RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDN 289 I + Y +S L + DP KR E+ +H++F + A+ + Sbjct: 263 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQE 322 >6CKI-A nrPDB Length = 316 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 125/312 (40%), Gaps = 29/312 (9%) Query: 8 GPMDLPIMHDSDRYELVK-DIGSGNFGVARLMRDKQSNELVAVKYIERGE-KIDENVKRE 65 G D D Y+L + +G G + + +++ AVK IE+ I V RE Sbjct: 1 GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFRE 60 Query: 66 IINHRSLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 + + H N++ E +V E GG + I F+E EA Q + Sbjct: 61 VEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 120 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPK--------S 175 S + + H + HRDLK EN L + + +KICDFG L+ + Sbjct: 121 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLT 180 Query: 176 TVGTPAYIAPEVL----LKKEYDGKVADVWSCGVTLYVMLVGAYPF-----------EDP 220 G+ Y+APEV+ + K D+WS GV LY++L G PF Sbjct: 181 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 240 Query: 221 EEPKNFRKTIHRILNVQYAIP--DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 P I +Y P D+ HIS + LIS++ V D +R+S ++ H W Sbjct: 241 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 279 KNLPADLMNDNT 290 P + + Sbjct: 301 GCAPENTLPTPM 312 >4AF3-A nrPDB Length = 292 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 15/279 (5%) Query: 7 SGPMDLPIMHDS-DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE----N 61 SG D+ H + D +E+ + +G G FG L R+K+S+ +VA+K + + + E Sbjct: 10 SGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQ 69 Query: 62 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFF 121 ++REI L HPNI+R + +++EYA GEL++ + + F E Sbjct: 70 LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIM 129 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 ++L + YCH +V HRD+K EN L LKI DFG+S + K+ GT Sbjct: 130 EELADALMYCHGKKVIHRDIKPEN--LLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLD 186 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y+ PE++ + ++ K D+W GV Y +LVG PFE +T RI+ V P Sbjct: 187 YLPPEMIEGRMHNEK-VDLWCIGVLCYELLVGNPPFESASH----NETYRRIVKVDLKFP 241 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + + LIS++ +P++R+ + ++ H W N Sbjct: 242 --ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 278 >4RA4-A nrPDB Length = 355 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 85/346 (24%), Positives = 152/346 (43%), Gaps = 39/346 (11%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR----EIINHRSL-RH 74 + + +G G+FG L K + EL A+K +++ I ++ E L + Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P + + T L VMEY +GG+L I G+F E +A F+ ++ G+ + H Sbjct: 81 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 140 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEY 193 + +RDLKL+N +LD +KI DFG K ++ ++ GTP YIAPE++ + Y Sbjct: 141 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 198 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 GK D W+ GV LY ML G PF+ +E + F+ + ++ +S E + Sbjct: 199 -GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYP------KSLSKEAVSI 251 Query: 254 ISRIFVADPAKRISI-----PEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEI 308 + PAKR+ ++R H +F + + + + + + F Sbjct: 252 CKGLMTKHPAKRLGCGPEGERDVREHAFF-RRIDWEKLENREIQPPFKPK---------- 300 Query: 309 MQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDS 354 V G +N + + T + ++ + +++D D + Sbjct: 301 --------VSGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEG 338 >3GC0-A nrPDB Length = 329 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 87/310 (28%), Positives = 126/310 (40%), Gaps = 37/310 (11%) Query: 7 SGPMDL-----PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKI 58 GP + P DRY + +G G +G D +NE VA+K I E + Sbjct: 17 QGPGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGV 76 Query: 59 DENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR 118 RE+ + L+H NI+ K VI L ++ EYA +L + + S + Sbjct: 77 PGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIK 135 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLL---DGSPAPRLKICDFGYSKSS-VLHSQPK 174 F QLI+GV++CH+ + HRDLK +N LL D S P LKI DFG +++ + Q Sbjct: 136 SFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFT 195 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 + T Y PE+LL + D+WS ML+ F E K + Sbjct: 196 HEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLG 255 Query: 235 -------NVQYAIPDYVHISPECR-HLISR----------------IFVADPAKRISIPE 270 A+PD+ P+ R + R + DP KRIS Sbjct: 256 LPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKN 315 Query: 271 IRNHEWFLKN 280 H +F N Sbjct: 316 ALEHPYFSHN 325 >3GC9-A nrPDB Length = 370 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 70/337 (20%), Positives = 134/337 (39%), Gaps = 44/337 (13%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHR 70 + R + ++ +GSG +G D + + VAVK + R + + +R E+ + Sbjct: 23 VWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLK 82 Query: 71 SLRHPNIVRFKEVILTPT------HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 L+H N++ +V T + +V G I + S++ +F QL Sbjct: 83 HLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKSQALSDEHVQFLVYQL 140 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 + G+ Y H+ + HRDLK N ++ L+I DFG ++ + + V T Y A Sbjct: 141 LRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFGLARQA--DEEMTGYVATRWYRA 196 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ------- 237 PE++L + + D+WS G + +L G F + ++ + + Sbjct: 197 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 256 Query: 238 ------------YAIPD------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +P + +P L+ R+ V D +R+S E H +F + Sbjct: 257 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 316 Query: 280 NLPADLMNDNTMTTQFDES-DQPGQSIEEIMQIIAEA 315 D +DES + +++EE ++ + Sbjct: 317 YHDP---EDEPEAEPYDESVEAKERTLEEWKELTYQE 350 >5NGU-A nrPDB Length = 381 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 80/335 (23%), Positives = 129/335 (38%), Gaps = 43/335 (12%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNI 77 RY + IG G +G+ D + VA+K I E + REI RH NI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 78 VRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 + ++I PT + IV + +L++ + S D +F Q++ G+ Y H Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIH 160 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST----VGTPAYIAPEVL 188 + V HRDLK N LL+ LKICDFG ++ + V T Y APE++ Sbjct: 161 SANVLHRDLKPSNLLLNT--TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH----------------R 232 L + K D+WS G L ML F + + Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 233 ILNVQYAIPD---------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 N ++P + + + L+ ++ +P KRI + + H + + Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 284 DLMNDNTMTTQFD-ESDQPGQSIEEIMQIIAEATV 317 +FD E D + E++ ++I E T Sbjct: 339 SDEPIAEAPFKFDMELDDLPK--EKLKELIFEETA 371 >3C51-A nrPDB Length = 543 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 90/352 (25%), Positives = 147/352 (41%), Gaps = 29/352 (8%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPNIVRF 80 + +G G FG + K + +L A K + + + E + IV Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYCHAMQV 136 T T L +VM +GG++ I N F E A F+ Q++SG+ + H + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLKKEYDG 195 +RDLK EN LLD ++I D G + ++ K GTP ++APE+LL +EYD Sbjct: 311 IYRDLKPENVLLDDD--GNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDF 368 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 D ++ GVTLY M+ PF E ++ R+L PD SP + Sbjct: 369 -SVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD--KFSPASKDFCE 425 Query: 256 RIFVADPAKRISIPE-----IRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQ 310 + DP KR+ + +R H F +++ + +T F D + I Sbjct: 426 ALLQKDPEKRLGFRDGSCDGLRTHPLF-RDISWRQLEAGMLTPPF-VPDSRTVYAKNIQD 483 Query: 311 IIAEATVPP-----AGTQNLNHYLTGSLDI---DDDMEEDLESDLDDLDIDS 354 + A +TV A T+ + +G+ I ++ +E + DL+ D Sbjct: 484 VGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDG 535 >4APC-A nrPDB Length = 350 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 149/323 (46%), Gaps = 18/323 (5%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 ++Y ++ IG G+FG A L++ + +K I K E +RE+ +++HP Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISGVSYCHA 133 NIV+++E L IVM+Y GG+LF+RI F ED+ +F Q+ + + H Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 143 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLKKE 192 ++ HRD+K +N L +++ DFG ++ + ++ +GTP Y++PE+ K Sbjct: 144 RKILHRDIKSQNIFLTKDGT--VQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKP 201 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Y+ K +D+W+ G LY + + F E + + + +I++ + P +H S + R Sbjct: 202 YNNK-SDIWALGCVLYELCTLKHAF----EAGSMKNLVLKIISGSFP-PVSLHYSYDLRS 255 Query: 253 LISRIFVADPAKRISIPEIRNHEWFLKNLP----ADLMNDNTMTTQFDESDQPGQSIEEI 308 L+S++F +P R S+ I + K + L+ + F + + Sbjct: 256 LVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRP 315 Query: 309 MQIIAEATVPPAGTQNLNHYLTG 331 +V PA G Sbjct: 316 ASGQNSISVMPAQKITKPAAKYG 338 >3Q53-A nrPDB Length = 306 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 124/273 (45%), Gaps = 9/273 (3%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHR 70 + + +Y + IG G G D + + VA++ + + + E + EI+ R Sbjct: 14 VSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMR 73 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 ++PNIV + + L L +VMEY +GG L + + E + ++ + + + Sbjct: 74 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEF 132 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLL 189 H+ QV HRD+K +N LL + +K+ DFG+ +ST VGTP ++APEV+ Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT 190 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 +K Y G D+WS G+ M+ G P+ + R N + + +S Sbjct: 191 RKAY-GPKVDIWSLGIMAIEMIEGEPPYLNENP---LRALYLIATNGTPELQNPEKLSAI 246 Query: 250 CRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 R ++R D KR S E+ H++ P Sbjct: 247 FRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKP 279 >2XIK-A nrPDB Length = 294 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 71/266 (26%), Positives = 117/266 (43%), Gaps = 12/266 (4%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRH 74 + + + IG G+FG D + E+VA+K I+ E E++++EI Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 76 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P I R+ L T L I+MEY GG + + G E ++++ G+ Y H+ Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHSE 135 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEY 193 + HRD+K N LL +K+ DFG + + + VGTP ++APEV+ + Y Sbjct: 136 RKIHRDIKAANVLLSEQ--GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D K AD+WS G+T + G P D + + I + H S + Sbjct: 194 DFK-ADIWSLGITAIELAKGEPPNSDLHP----MRVLFLIPKNSPPTLEGQH-SKPFKEF 247 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLK 279 + DP R + E+ H++ + Sbjct: 248 VEACLNKDPRFRPTAKELLKHKFITR 273 >4ZSG-A nrPDB Length = 347 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 128/323 (39%), Gaps = 44/323 (13%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI---DENVKREIINHRSLRH 74 D YE+++ IG+G +GV R + + + VA+K I + + RE+ + +H Sbjct: 6 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH 65 Query: 75 PNIVRFKEVIL------TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 NI+ K+++ + +V++ +L + I ++ + + R+F QL+ G+ Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAYI 183 Y H+ QV HRDLK N L++ + LKI DFG ++ V T Y Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENC--ELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI------------- 230 APE++L + D+WS G ML F + + Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 231 -------HRILNVQYAIP-DYVHISP----ECRHLISRIFVADPAKRISIPEIRNHEWFL 278 I ++ P + + P + L+ R+ +P+ RIS H + Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 279 KNLPADLMNDNTMTTQFDESDQP 301 K D ++ FD + Sbjct: 303 KYHDPD--DEPDCAPPFDFAFDR 323 >1JNK-A nrPDB Length = 423 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 82/360 (22%), Positives = 141/360 (39%), Gaps = 56/360 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D + VA+K + R + + KR E++ + + H N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 77 IVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDEAR--FFFQQLISGV 128 I+ V L +VME +C + D R + Q++ G+ Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + H+ + HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 178 KHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR--------ILNVQYAI 240 L Y + D+WS G + M+ F + + K I + + +Q + Sbjct: 236 LGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 241 PDYVHISPE----------------------------CRHLISRIFVADPAKRISIPEIR 272 +YV P+ R L+S++ V DPAKRIS+ + Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 273 NHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGS 332 H + + + D+ +IEE ++I + + + + N + G Sbjct: 355 QHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN-SEEKTKNGVVKGQ 413 >3ZDU-A nrPDB Length = 325 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 118/290 (40%), Gaps = 30/290 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 + YE + +G G++G + K + ++VA+K + +++ REI + H N Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 62 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V EV + +V E+ L E R + Q++ + Y H+ + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 HRD+K EN L+ S K+CDFG++++ V T Y APE++LK G Sbjct: 123 IHRDIKPENILVSQSGIT--KLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP------- 248 K D+W+ G + M G + K + ++ N+ + + SP Sbjct: 181 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 240 Query: 249 ------------------ECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 ++ DPA RIS ++ +HE+F ++ Sbjct: 241 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >6QAU-A nrPDB Length = 280 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 81/283 (28%), Positives = 135/283 (47%), Gaps = 15/283 (5%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQ-SNELVAVKYIERGEKIDENVK--R 64 G + ++ D + Y +G G F V R +Q ++ VA+K I + + + Sbjct: 1 GGGSMEVVGDFE-YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK 59 Query: 65 EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 EI + L+H NIV +V P + +VMEY +GG+L + + G SED R F Q+ Sbjct: 60 EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQI 119 Query: 125 ISGVSYCHAMQVCHRDLKLENTLL-------DGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 + + H+ + HRDLK +N LL R+KI DFG+++ + Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC 179 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 G+P Y+APEV++ + YD K AD+WS G +Y LVG PF+ P++ R + ++ Sbjct: 180 GSPMYMAPEVIMSQHYDAK-ADLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLM 237 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 +IP SP +L+ + + R+ +H + + Sbjct: 238 PSIPR--ETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 278 >5LOH-A nrPDB Length = 341 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 141/322 (43%), Gaps = 22/322 (6%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKRE 65 + +P + + +VK I G FG L + + +L AVK +++ + I++N V+ E Sbjct: 27 IAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAE 84 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 + P IV + + ++ +VMEY GG++ + G F E+ A + ++ Sbjct: 85 RDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVA 144 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-------QPKSTVG 178 + Y H + HRDLK +N L+ +K+ DFG SK ++ ++ G Sbjct: 145 LALDYLHRHGIIHRDLKPDNMLISNE--GHIKLTDFGLSKVTLNRDINMMDILTTRTFCG 202 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 TP Y+APE+LL + + G D W+ GV L+ L G PF D + F+ IL Sbjct: 203 TPDYLAPELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQ----NILKRDI 257 Query: 239 AIPD-YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDE 297 P+ +S + + + D KR + E++ H F ++ + + TM Sbjct: 258 PWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLF-SDVDWENLQHQTMPFIPQP 316 Query: 298 SDQPGQSIEEIMQIIAEATVPP 319 D+ S E TV Sbjct: 317 DDETDTSYFEARNTAQHLTVSG 338 >5UUU-A nrPDB Length = 547 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 87/355 (24%), Positives = 150/355 (42%), Gaps = 38/355 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL------ 72 + + + + IG G FG R + ++ A+K +++ + + +N R + Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 257 Query: 73 -RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 P IV TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + Sbjct: 258 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 317 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H V +RDLK N LLD ++I D G + +P ++VGT Y+APEVL K Sbjct: 318 HNRFVVYRDLKPANILLDEH--GHVRISDLGLA-CDFSKKKPHASVGTHGYMAPEVLQKG 374 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 AD +S G L+ +L G PF + K+ + L + +PD SPE R Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELR 431 Query: 252 HLISRIFVADPAKRI-----SIPEIRNHEW---------FLKNLPADLMN--------DN 289 L+ + D +R+ E++ + FL+ P L+ D Sbjct: 432 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 491 Query: 290 TMTTQFDESDQPGQSIEEIMQIIAEA---TVPPAGTQNLNHYLTGSLDIDDDMEE 341 FDE D G + + Q + T+ Q + + +++ + D E Sbjct: 492 FDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLE 546 >3PVW-A nrPDB Length = 695 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 87/355 (24%), Positives = 150/355 (42%), Gaps = 38/355 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL------ 72 + + + + IG G FG R + ++ A+K +++ + + +N R + Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 Query: 73 -RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 P IV TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + Sbjct: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H V +RDLK N LLD ++I D G + +P ++VGT Y+APEVL K Sbjct: 309 HNRFVVYRDLKPANILLDEH--GHVRISDLGLA-CDFSKKKPHASVGTHGYMAPEVLQKG 365 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 AD +S G L+ +L G PF + K+ + L + +PD SPE R Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELR 422 Query: 252 HLISRIFVADPAKRI-----SIPEIRNHEW---------FLKNLPADLMN--------DN 289 L+ + D +R+ E++ + FL+ P L+ D Sbjct: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 Query: 290 TMTTQFDESDQPGQSIEEIMQIIAEA---TVPPAGTQNLNHYLTGSLDIDDDMEE 341 FDE D G + + Q + T+ Q + + +++ + D E Sbjct: 483 FDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLE 537 >3E7O-A nrPDB Length = 360 Score = 243 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 137/362 (37%), Gaps = 55/362 (15%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE 60 MD S + RY+ +K IGSG G+ D VAVK + R + Sbjct: 4 MDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQT 63 Query: 61 NVKR---EIINHRSLRHPNIVRFKEVILTPTHL------AIVMEYASGGELFERICNAGR 111 + KR E++ + + H NI+ V L +VME +C Sbjct: 64 HAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIH 118 Query: 112 FSEDEAR--FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL 169 D R + Q++ G+ + H+ + HRDLK N ++ LKI DFG ++++ Sbjct: 119 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAST 176 Query: 170 HSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT 229 + V T Y APEV+L Y + D+WS G + ++ G+ F+ + + K Sbjct: 177 NFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKV 235 Query: 230 IHRILNV---------------------------QYAIPDYVHISPE---------CRHL 253 I ++ + PD++ S R L Sbjct: 236 IEQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDL 295 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIA 313 +S++ V DP KRIS+ E H + + ++ +IEE ++I Sbjct: 296 LSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIY 355 Query: 314 EA 315 + Sbjct: 356 KE 357 >2F9G-A nrPDB Length = 353 Score = 243 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 80/345 (23%), Positives = 128/345 (37%), Gaps = 51/345 (14%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 S ++L +G G +GV K + E+VA+K IE +K REI + +H Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 Query: 76 NIVRFK-----EVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 NI+ + + I+ E R+ + S+D ++F Q + V Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-----------HSQPKSTVGT 179 H V HRDLK N L++ + LK+CDFG ++ S V T Sbjct: 128 LHGSNVIHRDLKPSNLLINSNC--DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY- 238 Y APEV+L + DVWSCG L + + F + I Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 239 ------AIPD-------------------YVHISPECRHLISRIFVADPAKRISIPEIRN 273 P + ++P+ L+ R+ V DPAKRI+ E Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 Query: 274 HEWFLKNL-PADLMNDNTMTTQFDESDQPGQSI--EEIMQIIAEA 315 H + P D + F E D +++ +++ ++I Sbjct: 306 HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 >6BDL-A nrPDB Length = 347 Score = 243 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 73/286 (25%), Positives = 141/286 (49%), Gaps = 18/286 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDK-QSNELVAVKYIERGEKIDENVKREIINHRSL----R 73 + ++ +G G FG L++ K + ++ A+K +++ +D + I + + + Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 IVR +L ++ME GGEL+ + + G F + RF+ ++ +Y H+ Sbjct: 94 SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHS 153 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 + +RDLK EN +LD K+ DFG++K + + GTP Y+APE++L K + Sbjct: 154 KGIIYRDLKPENLILDHRGYA--KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGH 211 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D AD WS G+ +Y +L G+ PF P+ K + + I +++ I+ +L Sbjct: 212 DI-SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP----KKIAKNAANL 266 Query: 254 ISRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 I ++ +P++R+ + +I+ H+WF + + + T+T Sbjct: 267 IKKLCRDNPSERLGNLKNGVKDIQKHKWF-EGFNWEGLRKGTLTPP 311 >2XS0-A nrPDB Length = 386 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 82/360 (22%), Positives = 134/360 (37%), Gaps = 56/360 (15%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D VA+K + R + + KR E++ + + H N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 77 IVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDEAR--FFFQQLISGV 128 I+ V L IVME +C + D R + Q++ G+ Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 141 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + H+ + HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 142 KHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI-------- 240 L Y + D+WS G + M+ G F + + K I ++ Sbjct: 200 LGMGYK-ENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 241 -------PDYVHIS---------------------PECRHLISRIFVADPAKRISIPEIR 272 P Y S + R L+S++ V D +KRIS+ E Sbjct: 259 RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 273 NHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGS 332 H + + D+ +IEE ++I + + + N + G Sbjct: 319 QHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL-EERTKNGVIRGQ 377 >5DBX-A nrPDB Length = 328 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 124/294 (42%), Gaps = 22/294 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPN 76 D YEL + IGSG V + K E VA+K I + + + + +EI HPN Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 70 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERI--------CNAGRFSEDEARFFFQQLISGV 128 +V + + L +VM+ SGG + + I G E ++++ G+ Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 130 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ------PKSTVGTPAY 182 Y H HRDLK N LL + ++I DFG S K VGTP + Sbjct: 131 DYLHRNGQIHRDLKAGNILLGEDGS--VQIADFGVSAFLATGGDVTRNKVRKDFVGTPCW 188 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR-ILNVQYAIP 241 +APEV+ + AD+WS G+T + GA P+ K T+ ++ + Sbjct: 189 MAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVE 248 Query: 242 DYVHIS---PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT 292 D + R L+S DP+KR + E+ ++F K + + + +T Sbjct: 249 DKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLT 302 >4XEY-B nrPDB Length = 408 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 114/280 (40%), Gaps = 20/280 (7%) Query: 4 PAVSGPMDLPIMHDSDRYELVK-------DIGSGNFGVARLMRDKQSNELVAVKYIERGE 56 P + P + + D++E+ + +G G +G K+ + VAVK ++ Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 162 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSE 114 E +E + ++HPN+V+ V I+ E+ + G L + + CN + Sbjct: 163 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNA 222 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQ 172 + Q+ S + Y HRDL N L+ + +K+ DFG S+ + ++ Sbjct: 223 VVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYTA 280 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIH 231 + APE L ++ K +DVW+ GV L+ + G P+ + ++ Sbjct: 281 HAGAKFPIKWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGID-----LSQVY 334 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L Y + + L+ + +P+ R S EI Sbjct: 335 ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 374 >2FO0-A nrPDB Length = 495 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 114/280 (40%), Gaps = 20/280 (7%) Query: 4 PAVSGPMDLPIMHDSDRYELVK-------DIGSGNFGVARLMRDKQSNELVAVKYIERGE 56 P + P + + D++E+ + +G G +G K+ + VAVK ++ Sbjct: 195 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT 254 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSE 114 E +E + ++HPN+V+ V I+ E+ + G L + + CN + Sbjct: 255 MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNA 314 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQ 172 + Q+ S + Y HR+L N L+ + +K+ DFG S+ + ++ Sbjct: 315 VVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHL--VKVADFGLSRLMTGDTYTA 372 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIH 231 + APE L ++ K +DVW+ GV L+ + G P+ + ++ Sbjct: 373 HAGAKFPIKWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGID-----LSQVY 426 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L Y + + L+ + +P+ R S EI Sbjct: 427 ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 466 >4QTB-A nrPDB Length = 380 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 77/346 (22%), Positives = 132/346 (38%), Gaps = 49/346 (14%) Query: 4 PAVSGPMDLPIMHDSD---RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID- 59 P V G +++ D RY ++ IG G +G+ D VA+K I E Sbjct: 23 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY 82 Query: 60 -ENVKREIINHRSLRHPNIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFS 113 + REI RH N++ ++++ T + IV + +L++ + + S Sbjct: 83 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LS 140 Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 173 D +F Q++ G+ Y H+ V HRDLK N L++ LKICDFG ++ + Sbjct: 141 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDH 198 Query: 174 KST----VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT 229 V T Y APE++L + K D+WS G L ML F Sbjct: 199 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 258 Query: 230 IH----------------RILNVQYAIPD---------YVHISPECRHLISRIFVADPAK 264 + + N ++P + + L+ R+ +P K Sbjct: 259 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 318 Query: 265 RISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQ 310 RI++ E H + + D T +E ++++ + Sbjct: 319 RITVEEALAHPYLEQYY------DPTDEPVAEEPFTFAMELDDLPK 358 >4WNO-A nrPDB Length = 287 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 77/270 (28%), Positives = 123/270 (45%), Gaps = 16/270 (5%) Query: 20 RYELVKD--IGSGNFGVARLMRDKQSNE-LVAVKYIERGEKIDENVK--REIINHRSLRH 74 ++E + IG G F V R + +++ VAVK I + +EI + L+H Sbjct: 17 KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 NIV + + +VMEY +GG+L + + SED R F QQ+ + H+ Sbjct: 77 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSK 136 Query: 135 QVCHRDLKLENTLLD-------GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + HRDLK +N LL + R+KI DFG+++ + + G+P Y+APEV Sbjct: 137 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEV 196 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 ++ + YDGK AD+WS G +Y L G PF+ P++ R + + IP Sbjct: 197 IMSQHYDGK-ADLWSIGTIVYQCLTGKAPFQ-ASSPQDLRLFYEKNKTLVPTIPRETSAP 254 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWF 277 L + R+ E +H + Sbjct: 255 LRQLLLALL--QRNHKDRMDFDEFFHHPFL 282 >3PFQ-A nrPDB Length = 674 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 88/346 (25%), Positives = 154/346 (44%), Gaps = 39/346 (11%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RH 74 + + +G G+FG L K ++EL AVK +++ I D++V+ ++ R L + Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 401 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P + + T L VMEY +GG+L I GRF E A F+ ++ G+ + + Sbjct: 402 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 461 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEY 193 + +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ + Y Sbjct: 462 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 519 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 GK D W+ GV LY ML G PFE +E + F+ + NV Y +S E + Sbjct: 520 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAI 572 Query: 254 ISRIFVADPAKRISI-----PEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEI 308 + P KR+ +I+ H +F + + + + + + Sbjct: 573 CKGLMTKHPGKRLGCGPEGERDIKEHAFF-RYIDWEKLERKEIQPPYKPK---------- 621 Query: 309 MQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDS 354 +N + + T + ++++ ++D + + Sbjct: 622 --------ASGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEG 659 >1UA2-A nrPDB Length = 346 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 130/337 (38%), Gaps = 34/337 (10%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK------IDENVK 63 M L + + RYE + +G G F RDK +N++VA+K I+ G + I+ Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQ 122 REI + L HPNI+ + +++++V ++ +L I + + + + Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML 119 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPA 181 + G+ Y H + HRDLK N LLD + LK+ DFG +KS + V T Sbjct: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRW 177 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA-- 239 Y APE+L G D+W+ G L +L+ + + + Sbjct: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 Query: 240 -----IPDYVHIS---------------PECRHLISRIFVADPAKRISIPEIRNHEWFL- 278 +PDYV + LI +F+ +P RI+ + ++F Sbjct: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Query: 279 KNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEA 315 + P + + I + EA Sbjct: 298 RPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA 334 >3M42-A nrPDB Length = 299 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 141/309 (45%), Gaps = 37/309 (11%) Query: 19 DRYELV-KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 D Y++ + +G G G + +K++ E A+K + + +RE+ H R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPH 72 Query: 77 IVRFKEVILT----PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 H++ + HRD+K EN L P LK+ DFG++K + Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------------- 171 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 172 GEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 230 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 E + LI + +P +R++I E NH W +++ +T ++ ++ EE Sbjct: 231 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 290 Query: 308 IMQIIAEAT 316 + +A Sbjct: 291 MTSALATMR 299 >2I0E-A nrPDB Length = 353 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 90/321 (28%), Positives = 149/321 (46%), Gaps = 24/321 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL----RH 74 + + +G G+FG L K ++EL AVK +++ I D++V+ ++ R L + Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 80 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P + + T L VMEY +GG+L I GRF E A F+ ++ G+ + + Sbjct: 81 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 140 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLKKEY 193 + +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ + Y Sbjct: 141 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 198 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 GK D W+ GV LY ML G PFE +E + F+ + NV Y +S E + Sbjct: 199 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYP----KSMSKEAVAI 251 Query: 254 ISRIFVADPAKRISI-----PEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEI 308 + P KR+ +I+ H +F + + + + + + + G++ E Sbjct: 252 CKGLMTKHPGKRLGCGPEGERDIKEHAFF-RYIDWEKLERKEIQPPY-KPKACGRNAENF 309 Query: 309 MQIIAEATVPPAGTQNLNHYL 329 + PP T + Sbjct: 310 DR--FFTRHPPVLTPPDQEVI 328 >5D7A-A nrPDB Length = 308 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 131/297 (44%), Gaps = 23/297 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHPNIVR 79 +ELV+ +G+G +G R ++ +L A+K ++ +E +K+EI + H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 80 FKEVILTPTH------LAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSYC 131 + + L +VME+ G + + I N E+ + ++++ G+S+ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLL- 189 H +V HRD+K +N LL + +K+ DFG S + + +GTP ++APEV+ Sbjct: 139 HQHKVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 196 Query: 190 ----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 YD K +D+WS G+T M GA P D + + I Sbjct: 197 DENPDATYDFK-SDLWSLGITAIEMAEGAPPLCDMHP----MRALFLIPRNPAPRLKSKK 251 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPG 302 S + + I V + ++R + ++ H F+++ P + + D + + Sbjct: 252 WSKKFQSFIESCLVKNHSQRPATEQLMKHP-FIRDQPNERQVRIQLKDHIDRTKKKR 307 >6CCF-A nrPDB Length = 290 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 91/297 (30%), Positives = 137/297 (46%), Gaps = 47/297 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAV----------------------------- 49 ++Y+L +IG G +GV RL ++ + A+ Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 50 --KYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTP--THLAIVMEYASGGELFER 105 K + E V +EI + L H N+V+ EV+ P +L +V + G + E Sbjct: 65 PAKQL----LPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV 120 Query: 106 ICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK 165 C+ FSE++AR + + +I G+ Y H ++ HRD+K N LL +KI DFG S Sbjct: 121 PCD-KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD--GHVKIADFGVSN 177 Query: 166 SSVLHS-QPKSTVGTPAYIAPEVL--LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE 222 + Q ST GTPA++APE + + + GK DVW+ GVTLY + G PF D Sbjct: 178 QFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFI 237 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 RK I N P+ IS E + LI ++ +P RI +P+I+ H W K Sbjct: 238 LALHRK----IKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >3OZ6-A nrPDB Length = 388 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 84/383 (21%), Positives = 131/383 (34%), Gaps = 73/383 (19%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRS 71 H +YELVK +G G +G+ D+++ E+VAVK I + + +R EI+ Sbjct: 5 RHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTE 64 Query: 72 LR-HPNIVRFKEVIL--TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 L H NIV V+ + +V +Y +L I A ++ QLI + Sbjct: 65 LSGHENIVNLLNVLRADNDRDVYLVFDYME-TDLHAVI-RANILEPVHKQYVVYQLIKVI 122 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-------------------- 168 Y H+ + HRD+K N LL+ +K+ DFG S+S V Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAEC--HVKVADFGLSRSFVNIRRVTNNIPLSINENTENF 180 Query: 169 LHSQP--KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 QP V T Y APE+LL K D+WS G L +L G F Sbjct: 181 DDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQL 240 Query: 227 RKTIHRI-----------------------------------------LNVQYAIPDYVH 245 + I I N+ I Sbjct: 241 ERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKAD 300 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSI 305 + E L+ ++ +P KRIS + H + + + +D SI Sbjct: 301 CNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSI 360 Query: 306 EEIMQIIAEATVPPAGTQNLNHY 328 ++ ++ N + Sbjct: 361 DDYRNLVYSEISRRKRELISNKH 383 >2H8H-A nrPDB Length = 535 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 112/294 (38%), Gaps = 17/294 (5%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV 62 +P G + L +G G FG + + VA+K ++ G E Sbjct: 251 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF 309 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFF 120 +E + LRH +V+ V+ + + IV EY S G L + + + Sbjct: 310 LQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 368 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVG 178 Q+ SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + Sbjct: 369 AAQIASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKF 426 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQ 237 + APE L + K +DVWS G+ L + G P+ + + + Sbjct: 427 PIKWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERG 480 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMNDN 289 Y +P L+ + + +P +R + ++ ++F P +N Sbjct: 481 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 534 >2UV2-A nrPDB Length = 325 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 125/272 (45%), Gaps = 14/272 (5%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLR 73 ++ D +E++ ++G G FG ++K+++ L A K I+ + E+ E+ EI S Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCD 92 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISGVSYCH 132 HPNIV+ + +L I++E+ +GG + + +E + + +Q + ++Y H Sbjct: 93 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLL-- 189 ++ HRDLK N L +K+ DFG S + Q + S +GTP ++APEV++ Sbjct: 153 DNKIIHRDLKAGNILFTLD--GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 210 Query: 190 ---KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 + YD K ADVWS G+TL M P E R + + + Sbjct: 211 TSKDRPYDYK-ADVWSLGITLIEMAEIEPP---HHELNPMRVLLKIAKSEPPTLAQPSRW 266 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 S + + + + R + ++ H + Sbjct: 267 SSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >5Y86-A nrPDB Length = 588 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 123/338 (36%), Gaps = 65/338 (19%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 + +P H + RYE++K IG G+FG + D + + VA+K + ++ EI Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 Query: 70 RSLR------HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFF 121 L+ N++ E H+ + E S +L+E I FS R F Sbjct: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFA 316 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 Q ++ + H ++ H DLK EN LL K+ DFG S + + + + + Sbjct: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRF 374 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF-----------RKTI 230 Y APE++L Y D+WS G L +L G F +E K + Sbjct: 375 YRAPEIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Query: 231 HRILNVQYA-----IPDYVHISPEC----------------------------------- 250 + +Y IP Y ++ + Sbjct: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 Query: 251 --RHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 + R DP+ R++ + H W K++P L Sbjct: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLT 531 >1G3N-A nrPDB Length = 326 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 124/315 (39%), Gaps = 39/315 (12%) Query: 20 RYELVKDIGSGNFGVARLMRD-KQSNELVAVKYIERG---EKIDENVKREIINHRSLR-- 73 +YE V +IG G +G RD K VA+K + E + + RE+ R L Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 74 -HPNIVRFKEVIL-----TPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLI 125 HPN+VR +V T L +V E+ +L + + + QL+ Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 185 G+ + H+ +V HRDLK +N L+ S ++K+ DFG ++ S V T Y AP Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQYAIPDYV 244 EVLL+ Y D+WS G M F + K + I L + P V Sbjct: 189 EVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 245 HISPEC--------------------RHLISRIFVADPAKRISIPEIRNHEWFLKNLPAD 284 + + + L+ + +PAKRIS +H +F Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 Query: 285 LMNDNTMTTQFDESD 299 D+ + + S+ Sbjct: 308 ENLDSHLPPSQNTSE 322 >2VD5-A nrPDB Length = 412 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 125/298 (41%), Gaps = 23/298 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRH 74 D +E++K IG G F +++ KQ+ ++ A+K + + + + + E + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCHA 133 I + +L +VMEY GG+L + G R + ARF+ +++ + H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVLL-- 189 + HRD+K +N LLD +++ DFG +S VGTP Y++PE+L Sbjct: 181 LGYVHRDIKPDNILLD--RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAV 238 Query: 190 ----KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 G D W+ GV Y M G PF + + K +H ++ + D Sbjct: 239 GGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD-EG 297 Query: 246 ISPECRHLISRIFVADPAKRI---SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 + E R I R+ P R+ + R H +F L D + D+ F + Sbjct: 298 VPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFF-GLDWDGLRDS--VPPFTPDFE 351 >6CQF-A nrPDB Length = 297 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 71/271 (26%), Positives = 124/271 (45%), Gaps = 13/271 (4%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINH 69 D+ D Y+L++ +G G +G RDK S +LVA+K ++ D +++EI+ Sbjct: 8 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILIL 67 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 ++ RH NIV + L L I ME+ G L + G SE + + ++++ G++ Sbjct: 68 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEV- 187 Y H+ + HRD+K N L+ + A +++ DFG S + + +GTP ++APEV Sbjct: 128 YLHSQKKIHRDIKGANILI--NDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVA 185 Query: 188 -LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH- 245 + K ++ D+WS G+T + P D + + + Y P Sbjct: 186 AVALKGGYNELCDIWSLGITAIELAELQPPLFDVHP----LRVLFLMTKSGYQPPRLKEK 241 Query: 246 --ISPECRHLISRIFVADPAKRISIPEIRNH 274 S + I P KR S ++ +H Sbjct: 242 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2WQN-A nrPDB Length = 310 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 69/259 (26%), Positives = 112/259 (43%), Gaps = 14/259 (5%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK----REIINHRSLRHP 75 + + K IG G F VA+K ++ + +D + +EI + L HP Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARFFFQQLISGVSYC 131 N++++ + L IV+E A G+L I + + E +F QL S + + Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLK 190 H+ +V HRD+K N + + +K+ D G + + S VGTP Y++PE + + Sbjct: 153 HSRRVMHRDIKPANVFITATGV--VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE 210 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Y+ K +D+WS G LY M PF + N +I Y H S E Sbjct: 211 NGYNFK-SDIWSLGCLLYEMAALQSPFYGDK--MNLYSLCKKIEQCDYPPLPSDHYSEEL 267 Query: 251 RHLISRIFVADPAKRISIP 269 R L++ DP KR + Sbjct: 268 RQLVNMCINPDPEKRPDVT 286 >4YHJ-A nrPDB Length = 584 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 142/354 (40%), Gaps = 26/354 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPN 76 + + +G G FG + + + ++ A K +++ E ++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAM 134 +V T L +V+ +GG+L I N G F E A F+ +L G+ Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 ++ +RDLK EN LLD ++I D G + + + VGT Y+APEV+ ++Y Sbjct: 307 RIVYRDLKPENILLD--DRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYT 364 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 D W G +Y M+ G PF+ +E + + RI N + S + + + Sbjct: 365 FSP-DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE--KFSEDAKSIC 421 Query: 255 SRIFVADPAKRI-----SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIM 309 + +P+KR+ ++ H F K++ + N + F D ++++ Sbjct: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVF-KDINFRRLEANMLEPPF-CPDPHAVYCKDVL 479 Query: 310 QIIAEATVPP-----AGTQNLNHYLTGSLDI---DDDMEEDLESDLDDLDIDSS 355 I + V A + TG + I ++ +E D++ + + + Sbjct: 480 DIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEA 533 >1TKI-A nrPDB Length = 321 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 122/267 (45%), Gaps = 8/267 (2%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV 78 ++Y + +D+G G FG+ + S + K+++ VK+EI RH NI+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNIL 64 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 E + L ++ E+ SG ++FERI +A +E E + Q+ + + H+ + Sbjct: 65 HLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIG 124 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 H D++ EN + + +KI +FG ++ + P Y APEV + + Sbjct: 125 HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVH-QHDVVSTA 183 Query: 198 ADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD--YVHISPECRHLIS 255 D+WS G +YV+L G PF + ++ I I+N +Y + + IS E + Sbjct: 184 TDMWSLGTLVYVLLSGINPF----LAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNLP 282 R+ V + R++ E H W + + Sbjct: 240 RLLVKERKSRMTASEALQHPWLKQKIE 266 >2XYN-A nrPDB Length = 292 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 107/266 (40%), Gaps = 14/266 (5%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 MD M +D + +G G +G + K+ + VAVK ++ E +E Sbjct: 24 MDKWEMERTD-ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 82 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISG 127 + ++HPN+V+ V IV EY G L + + CN + + Q+ S Sbjct: 83 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 142 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAP 185 + Y HRDL N L+ + +K+ DFG S+ + ++ + AP Sbjct: 143 MEYLEKKNFIHRDLAARNCLVGENHV--VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 200 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 E L + K +DVW+ GV L+ + G P+ + ++ +L Y + Sbjct: 201 ESLAYNTFSIK-SDVWAFGVLLWEIATYGMSPYPGID-----LSQVYDLLEKGYRMEQPE 254 Query: 245 HISPECRHLISRIFVADPAKRISIPE 270 P+ L+ + PA R S E Sbjct: 255 GCPPKVYELMRACWKWSPADRPSFAE 280 >6HXF-B nrPDB Length = 302 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 66/270 (24%), Positives = 123/270 (45%), Gaps = 12/270 (4%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE-RGEKIDENVKREIINHRSLR 73 + ++ +E+V ++G G FG ++K++ L A K IE + E+ E+ EI + Sbjct: 15 LDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCD 74 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCH 132 HP IV+ L I++E+ GG + + R +E + + +Q++ +++ H Sbjct: 75 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 134 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 + ++ HRDLK N L+ + +++ DFG +K+ + S +GTP ++APEV++ + Sbjct: 135 SKRIIHRDLKAGNVLM--TLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 192 EY----DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 AD+WS G+TL M P E R + + + S Sbjct: 193 TMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKIAKSDPPTLLTPSKWS 249 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWF 277 E R + +P R S ++ H + Sbjct: 250 VEFRDFLKIALDKNPETRPSAAQLLEHPFV 279 >3MIA-A nrPDB Length = 351 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 138/333 (41%), Gaps = 49/333 (14%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREI 66 ++ P + +YE + IG G FG R +++ + VA+K + E REI Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 67 INHRSLRHPNIVRFKEVILTP--------THLAIVMEYASGGELFERICNA-GRFSEDEA 117 + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-----HSQ 172 + Q L++G+ Y H ++ HRD+K N L+ LK+ DFG +++ L ++ Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV--LKLADFGLARAFSLAKNSQPNR 184 Query: 173 PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN------- 225 + V T Y PE+LL + G D+W G + M + + E Sbjct: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 Query: 226 ----------------FRKTIHRILNVQYAIPDYVHI---SPECRHLISRIFVADPAKRI 266 + + + + + D + P LI ++ V DPA+RI Sbjct: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 Query: 267 SIPEIRNHEWFLKN-LPADL--MNDNTMTTQFD 296 + NH++F + +P+DL M +T+ F+ Sbjct: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 >6F3F-A nrPDB Length = 455 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 112/294 (38%), Gaps = 17/294 (5%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV 62 +P G + L +G G FG + + VA+K ++ G E Sbjct: 171 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF 229 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFF 120 +E + LRH +V+ V+ + + IV EY + G L + + + Sbjct: 230 LQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDM 288 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVG 178 Q+ SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + Sbjct: 289 SAQIASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKF 346 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQ 237 + APE L + K +DVWS G+ L + G P+ + + + Sbjct: 347 PIKWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERG 400 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMNDN 289 Y +P L+ + + +P +R + ++ ++F P +N Sbjct: 401 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 454 >3FI2-A nrPDB Length = 353 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 81/346 (23%), Positives = 135/346 (39%), Gaps = 66/346 (19%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 RY+ +K IGSG G+ D + VA+K + R + + KR E++ + + H N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 77 IVRFKEVILTPTHL------AIVMEYASGGELFERICNAGRFSEDEAR--FFFQQLISGV 128 I+ V L +VME +C + D R + Q++ G+ Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 139 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + H+ + HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 140 KHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR--------ILNVQYAI 240 L Y + D+WS G + M+ F + + K I + + +Q + Sbjct: 198 LGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 241 PDYVHISPE----------------------------CRHLISRIFVADPAKRISIPEIR 272 +YV P+ R L+S++ V DPAKRIS+ + Sbjct: 257 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 316 Query: 273 NHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVP 318 H + N D+ +IEE ++I + + Sbjct: 317 QHPYI-----------NVWYXXXXXXDEREHTIEEWKELIYKEVMN 351 >3PPZ-A nrPDB Length = 309 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 127/290 (43%), Gaps = 24/290 (8%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN---VKREI 66 MD+P + + IG+G+FG VAVK + + E RE+ Sbjct: 32 MDIPWC----DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREV 85 Query: 67 INHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG---RFSEDEARFFFQQ 123 + LRHPNIV F + P +L+IV EY S G L+ + +G + E Sbjct: 86 AIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYD 145 Query: 124 LISGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKSTVGTP 180 + G++Y H + HRDLK N L+D +K+CDFG S+ + KS GTP Sbjct: 146 VAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYT--VKVCDFGLSRLKASTFLSSKSAAGTP 203 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 ++APEVL + + K +DV+S GV L+ + P+ + + + ++ Sbjct: 204 EWMAPEVLRDEPSNEK-SDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIP- 261 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMND 288 +++P+ +I + +P KR S I + +P +D Sbjct: 262 ---RNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSD 308 >6NPU-A nrPDB Length = 298 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 58/267 (21%), Positives = 110/267 (41%), Gaps = 20/267 (7%) Query: 17 DSDRYELVK-------DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 + D++E+ + +G G +G K+ + VAVK ++ E +E Sbjct: 17 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 76 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISG 127 + ++HPN+V+ V I+ E+ + G L + + CN + + Q+ S Sbjct: 77 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 136 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAP 185 + Y HRDL N L+ + +K+ DFG S+ + ++ + AP Sbjct: 137 MEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 194 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 E L ++ K +DVW+ GV L+ + G P+ + ++ +L Y + Sbjct: 195 ESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGID-----LSQVYELLEKDYRMERPE 248 Query: 245 HISPECRHLISRIFVADPAKRISIPEI 271 + L+ + +P+ R S EI Sbjct: 249 GCPEKVYELMRACWQWNPSDRPSFAEI 275 >5AIR-A nrPDB Length = 430 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 81/332 (24%), Positives = 126/332 (37%), Gaps = 38/332 (11%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV 62 V+ P P Y K IG+G+FGV + S ELVA+K + + ++ Sbjct: 48 TTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-- 105 Query: 63 KREIINHRSLRHPNIVRFKEVIL------TPTHLAIVMEYASGGELF---ERICNAGRFS 113 RE+ R L H NIVR + +L +V++Y Sbjct: 106 -RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP 164 Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 173 + + QL ++Y H+ +CHRD+K +N LLD LK+CDFG +K V Sbjct: 165 VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPN 223 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 S + + Y APE++ DVWS G L +L+G F + I + Sbjct: 224 VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVL 283 Query: 234 LNV-------------QYAIPD-----YVHI-----SPECRHLISRIFVADPAKRISIPE 270 ++ P + + PE L SR+ P R++ E Sbjct: 284 GTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLE 343 Query: 271 IRNHEWF--LKNLPADLMNDNTMTTQFDESDQ 300 H +F L++ L N F+ + Q Sbjct: 344 ACAHSFFDELRDPNVKLPNGRDTPALFNFTTQ 375 >4FR4-A nrPDB Length = 384 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 129/286 (45%), Gaps = 13/286 (4%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR----EIINHRSL 72 + D +E+++ IG G+FG +++ + ++ A+KY+ + + ++ N R E+ + L Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 HP +V + +V++ GG+L + F E+ + F +L+ + Y Sbjct: 73 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 132 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 ++ HRD+K +N LLD + I DF + +Q + GT Y+APE+ ++ Sbjct: 133 NQRIIHRDMKPDNILLDEH--GHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRK 190 Query: 193 --YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 D WS GVT Y +L G P+ + ++ +H P S E Sbjct: 191 GAGYSFAVDWWSLGVTAYELLRGRRPY-HIRSSTSSKEIVHTFETTVVTYP--SAWSQEM 247 Query: 251 RHLISRIFVADPAKRIS-IPEIRNHEWFLKNLPADLMNDNTMTTQF 295 L+ ++ +P +R S + +++N + ++ D + + F Sbjct: 248 VSLLKKLLEPNPDQRFSQLSDVQNFPYMN-DINWDAVFQKRLIPGF 292 >4HZS-A nrPDB Length = 341 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 134/318 (42%), Gaps = 27/318 (8%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMR-DKQSNELV--AVKYIERG----EKIDE 60 G L + L++ +G G+FGV R D S + V AVK ++ + + Sbjct: 1 GSQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARF 119 + RE+ SL H N++R V+LTP + +V E A G L +R+ G F Sbjct: 61 DFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSR 119 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK----S 175 + Q+ G+ Y + + HRDL N LL +KI DFG ++ + Sbjct: 120 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL--VKIGDFGLMRALPQNDDHYVMQEH 177 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRIL 234 A+ APE L + + +D W GVTL+ M G P+ N + +H+I Sbjct: 178 RKVPFAWCAPESLKTRTFSH-ASDTWMFGVTLWEMFTYGQEPWIGL----NGSQILHKID 232 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 +P + +++ + + P R + +R+ + L+ P D+ Sbjct: 233 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDM----RALQD 286 Query: 295 FDESDQPGQSIEEIMQII 312 F+E D+ + +++ +I Sbjct: 287 FEEPDKLHIQMNDVITVI 304 >5EFQ-A nrPDB Length = 347 Score = 234 bits (597), Expect = 6e-62, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 129/315 (40%), Gaps = 46/315 (14%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 D+++++ IG G +G RDK + E+VA+K + E REI R L H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 76 NIVRFKEVILTPTH----------LAIVMEYASGGELFERICNA-GRFSEDEARFFFQQL 124 +I+ KE++ +V EY +L + + F+E+ + F +QL Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFMRQL 129 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 182 + G+ YCH HRD+K N LL+ ++K+ DFG ++ SS + V T Y Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNN--RGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------- 233 PE+LL +E DVWSCG L + F+ +E + I RI Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQL-ELISRICGSPCPAVW 246 Query: 234 -------------LNVQYA---IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 QY ++V I L + DP+KR + + E F Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCE-F 305 Query: 278 LKNLPADLMNDNTMT 292 L+++ M + Sbjct: 306 LRDVEPSKMPPPDLP 320 >4E7W-A nrPDB Length = 394 Score = 233 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 132/327 (40%), Gaps = 39/327 (11%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 Y K IG+G+FGV + +S+E VA+K + + ++ RE+ R ++HPN+V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN---RELQIMRIVKHPNVVDL 97 Query: 81 KEVIL------TPTHLAIVMEYAS---GGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 K L +V+EY + + QL+ ++Y Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H++ +CHRD+K +N LLD P+ LK+ DFG +K + S + + Y APE++ Sbjct: 158 HSIGICHRDIKPQNLLLD-PPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGA 216 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------HRILNVQYAIP 241 D+WS G + ++ G F + I + +N Y Sbjct: 217 TNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEH 276 Query: 242 DYVHI-------------SPECRHLISRIFVADPAKRISIPEIRNHEWF--LKNLPADLM 286 + I P+ LISR+ P+ R++ E H +F L+ A + Sbjct: 277 KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGEARMP 336 Query: 287 NDNTMTTQFDESDQPGQSIEEIMQIIA 313 N + F+ + + +++ + Sbjct: 337 NGRELPPLFNWTKEELSVRPDLISRLV 363 >6E2O-A nrPDB Length = 295 Score = 233 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 79/259 (30%), Positives = 128/259 (49%), Gaps = 10/259 (3%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYI-ERGEKIDENVKREIINHRSLRHPNIVRFKEVI 84 +G G +G+ RD + +A+K I ER + + + EI H+ L+H NIV++ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 88 Query: 85 LTPTHLAIVMEYASGGELFERICNA-GRF--SEDEARFFFQQLISGVSYCHAMQVCHRDL 141 + I ME GG L + + G +E F+ +Q++ G+ Y H Q+ HRD+ Sbjct: 89 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 148 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLKKEY-DGKVAD 199 K +N L++ + + LKI DFG SK ++ ++ GT Y+APE++ K GK AD Sbjct: 149 KGDNVLIN-TYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFV 259 +WS G T+ M G PF + EP+ + + V IP+ +S E + I + F Sbjct: 208 IWSLGCTIIEMATGKPPFYELGEPQAAMFKVG-MFKVHPEIPE--SMSAEAKAFILKCFE 264 Query: 260 ADPAKRISIPEIRNHEWFL 278 DP KR ++ E+ Sbjct: 265 PDPDKRACANDLLVDEFLK 283 >3LM0-A nrPDB Length = 327 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 137/303 (45%), Gaps = 12/303 (3%) Query: 14 IMHDSDRYELV--KDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIIN 68 M + + + ++ K++G G F V R K + + A K++++ G+ + EI Sbjct: 22 SMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAV 81 Query: 69 HRSLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLI 125 + P ++ EV + + +++EYA+GGE+F A SE++ +Q++ Sbjct: 82 LELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQIL 141 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 GV Y H + H DLK +N LL P +KI DFG S+ + + +GTP Y+A Sbjct: 142 EGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLA 201 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE+L D+W+ G+ Y++L PF + + + +NV Y+ + Sbjct: 202 PEILNYDPITT-ATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQ--VNVDYSEETFS 258 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQS 304 +S I + V +P KR + +H W + +L + ++ D +S Sbjct: 259 SVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRS 318 Query: 305 IEE 307 E+ Sbjct: 319 SED 321 >1U5R-A nrPDB Length = 348 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 135/304 (44%), Gaps = 21/304 (6%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPN 76 + +++IG G+FG RD +++E+VA+K + K +++ +E+ + LRHPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 77 IVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 ++++ L +VMEY G +L E + E E + G++Y H+ Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---KK 191 + HRD+K N LL +K+ DFG + S VGTP ++APEV+L + Sbjct: 174 NMIHRDVKAGNILLSE--PGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEG 228 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 +YDGK DVWS G+T + P + N ++ I + H S R Sbjct: 229 QYDGK-VDVWSLGITCIELAERKPPLFNM----NAMSALYHIAQNESPALQSGHWSEYFR 283 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQI 311 + + P R + + H + L+ P ++ D T+ + ++ +I Sbjct: 284 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKI 343 Query: 312 IAEA 315 + + Sbjct: 344 LFQE 347 >4NST-A nrPDB Length = 351 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 84/347 (24%), Positives = 136/347 (39%), Gaps = 56/347 (16%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 D+++++ IG G +G +DK + ELVA+K + E REI R L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 76 NIVRFKEVILTPTH----------LAIVMEYASGGELFERICNA-GRFSEDEARFFFQQL 124 ++V KE++ +V EY +L + + FSED + F +QL Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 182 + G+ YCH HRD+K N LL+ S ++K+ DFG ++ +S + V T Y Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNS--GQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF---------------- 226 PE+LL +E DVWSCG L + F+ E Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 227 -------------RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +K R L +++ I L+ + DP+KR + + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSF-----IPSAALDLLDHMLTLDPSKRCTAEQTLQ 304 Query: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQ--IIAEATVP 318 + FLK++ M + D + + Q ++ E P Sbjct: 305 SD-FLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPP 350 >2GCD-A nrPDB Length = 309 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 135/304 (44%), Gaps = 21/304 (6%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRHPN 76 + +++IG G+FG RD +++E+VA+K + K +++ +E+ + LRHPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 77 IVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 ++++ L +VMEY G +L E + E E + G++Y H+ Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---KK 191 + HRD+K N LL +K+ DFG + S VGTP ++APEV+L + Sbjct: 135 NMIHRDVKAGNILLSE--PGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEG 189 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 +YDGK DVWS G+T + P + N ++ I + H S R Sbjct: 190 QYDGK-VDVWSLGITCIELAERKPPLFNM----NAMSALYHIAQNESPALQSGHWSEYFR 244 Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQI 311 + + P R + + H + L+ P ++ D T+ + ++ +I Sbjct: 245 NFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKI 304 Query: 312 IAEA 315 + + Sbjct: 305 LFQE 308 >6BXI-A nrPDB Length = 333 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 134/302 (44%), Gaps = 49/302 (16%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRH 74 + +E +K IG G FG RL++ K + + A+K + + + +++ ++ E Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 +V+ +L ++ME+ GG++ + +E+E +F+ + + + H + Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 125 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-----------------------LHS 171 HRD+K +N LLD +K+ DFG ++S Sbjct: 126 GFIHRDIKPDNLLLDSK--GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 172 QPK-------------STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE 218 + K STVGTP YIAPEV ++ Y+ K+ D WS GV +Y ML+G PF Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFC 242 Query: 219 DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISI---PEIRNHE 275 + ++K ++ P V IS + + LI R F + RI EI+++ Sbjct: 243 SETPQETYKKVMNW--KETLTFPPEVPISEKAKDLILR-FCCEWEHRIGAPGVEEIKSNS 299 Query: 276 WF 277 +F Sbjct: 300 FF 301 >5TUR-A nrPDB Length = 404 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 81/271 (29%), Positives = 122/271 (45%), Gaps = 24/271 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-------NVKREIINHR 70 +Y++ +GSG FG N VA+K++E+ D V E++ + Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 71 SLRHPN--IVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISG 127 + ++R + P +++E +LF+ I G E+ AR FF Q++ Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 245 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 V +CH V HRD+K EN L+D + LK+ DFG S + + + GT Y PE Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEW 303 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + Y G+ A VWS G+ LY M+ G PFE EE I+ Q +S Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVS 351 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFL 278 EC+HLI P+ R + EI+NH W Sbjct: 352 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 382 >3BGP-A nrPDB Length = 333 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 81/271 (29%), Positives = 122/271 (45%), Gaps = 24/271 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-------NVKREIINHR 70 +Y++ +GSG FG N VA+K++E+ D V E++ + Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 71 SLRHPN--IVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISG 127 + ++R + P +++E +LF+ I G E+ AR FF Q++ Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 174 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 V +CH V HRD+K EN L+D + LK+ DFG S + + + GT Y PE Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEW 232 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + Y G+ A VWS G+ LY M+ G PFE EE I+ Q +S Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVS 280 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFL 278 EC+HLI P+ R + EI+NH W Sbjct: 281 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 311 >4GS6-A nrPDB Length = 315 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 80/266 (30%), Positives = 124/266 (46%), Gaps = 18/266 (6%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 M D E+ + +G G FGV + + + VA+K IE E + E+ + Sbjct: 4 HMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE-SESERKAFIVELRQLSRVN 60 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRF---SEDEARFFFQQLISGVSY 130 HPNIV+ L P + +VMEYA GG L+ + A + A + Q GV+Y Sbjct: 61 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 118 Query: 131 CHAMQ---VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 H+MQ + HRDLK N LL LKICDFG + + + + G+ A++APEV Sbjct: 119 LHSMQPKALIHRDLKPPNLLLVA-GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEV 175 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 Y K DV+S G+ L+ ++ PF++ P I ++ P ++ Sbjct: 176 FEGSNYSEK-CDVFSWGIILWEVITRRKPFDEIGGPAF---RIMWAVHNGTRPPLIKNLP 231 Query: 248 PECRHLISRIFVADPAKRISIPEIRN 273 L++R + DP++R S+ EI Sbjct: 232 KPIESLMTRCWSKDPSQRPSMEEIVK 257 >4RC3-A nrPDB Length = 289 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 83/281 (29%), Positives = 124/281 (44%), Gaps = 24/281 (8%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE------- 60 GP +Y++ +GSG FG N VA+K++E+ D Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 61 NVKREIINHRSLRHPN--IVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEA 117 V E++ + + ++R + P +++E +LF+ I G E+ A Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 120 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 R FF Q++ V +CH V HRD+K EN L+D + LK+ DFG S + + + Sbjct: 121 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFD 178 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 GT Y PE + Y G+ A VWS G+ LY M+ G PFE EE I+ Q Sbjct: 179 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQ 228 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 +S EC+HLI P+ R + EI+NH W Sbjct: 229 VFFRQ--RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 267 >5SYS-A nrPDB Length = 286 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 109/283 (38%), Gaps = 17/283 (6%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + L +G G FG + + VA+K ++ G E +E + LR Sbjct: 13 WEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLR 71 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVSYC 131 H +V+ V+ + + IV EY S G L + + + Q+ SG++Y Sbjct: 72 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYV 130 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 189 M HRDL+ N L+ + K+ DFG ++ ++ + + APE L Sbjct: 131 ERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 188 Query: 190 KKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K +DVWS G+ L + G P+ + + + Y +P Sbjct: 189 YGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERGYRMPCPPECPE 242 Query: 249 ECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMNDN 289 L+ + + DP +R + ++ ++F P +N Sbjct: 243 SLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 285 >4BGQ-A nrPDB Length = 304 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 129/294 (43%), Gaps = 40/294 (13%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 +++E++ +G G +GV R K+++E+VA+K + E++ E RE+ R+L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 76 NIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 NIV KE L +V EY EL E + N ++ + + QLI + +CH Sbjct: 72 NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCHK 129 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS--TVGTPAYIAPEVLLKK 191 + HRD+K EN L+ + LK+CDFG++++ + V T Y +PE+LL Sbjct: 130 NDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL--------NVQYAIPDY 243 Y GK D+WS G L + G F E TI ++L + Y+ P + Sbjct: 188 PY-GKSVDMWSVGCILGELSDGQPLFPGESEIDQLF-TIQKVLGPLPSEQMKLFYSNPRF 245 Query: 244 VH-------------------ISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 ++ L+ + DPA R + NH F Sbjct: 246 HGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >4EBW-A nrPDB Length = 304 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 117/263 (44%), Gaps = 18/263 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIER--GEKIDENVKREIINHRSLR 73 +R EL + IG G FG VA+K + + + E +E + R Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCH 132 HP+IV+ VI T + I+ME + GEL + + QL + ++Y Sbjct: 98 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLE 156 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLK 190 + + HRD+ N L+ + +K+ DFG S+ + K++ G ++APE + Sbjct: 157 SKRFVHRDIAARNVLVSSNDC--VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 214 Query: 191 KEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 + + +DVW GV ++ +L+ G PF+ + I RI N + +P + P Sbjct: 215 RRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNND----VIGRIENGE-RLPMPPNCPPT 268 Query: 250 CRHLISRIFVADPAKRISIPEIR 272 L+++ + DP++R E++ Sbjct: 269 LYSLMTKCWAYDPSRRPRFTELK 291 >4UYA-A nrPDB Length = 340 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 88/332 (26%), Positives = 134/332 (40%), Gaps = 29/332 (8%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-----ENVKREII 67 P+ +R EL + IG+G FG + VAVK + + D E+V+RE Sbjct: 20 PVHVAFERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREAR 77 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 LRHPNI+ + V L HL +V+E+A GG L R R + Q+ G Sbjct: 78 LFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARG 136 Query: 128 VSYCHAMQ---VCHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 + Y H + HRDLK N LL D LKI DFG ++ ++ +T G Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM-ATAG 195 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 A++APEV+ + K +D+WS GV L+ +L G P+ + + + + Sbjct: 196 AYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGIDGLA----VAYGVAVNKL 250 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDES 298 +P L+ + DP R S I L + +M + + Sbjct: 251 TLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ---LTAIEGAVMTEMPQESFHSMQ 307 Query: 299 DQPGQSIEEIMQIIAEATVPPAGTQNLNHYLT 330 D EI Q+ E ++ LT Sbjct: 308 DDW---KLEIQQMFDELRTKEKELRSREEELT 336 >5H2U-A nrPDB Length = 267 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 106/263 (40%), Gaps = 14/263 (5%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-EIINHRSLRH 74 + + L + +GSG FG K VA+K I R + + + + EI + LRH Sbjct: 3 RPREEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 61 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVSYCH 132 +I+ V+ + I+ E + G L E + + E Q+ G+ Y Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-YIAPEVLLKK 191 + HRDL N L+ + K+ DFG ++ P + APE L + Sbjct: 122 SQNYIHRDLAARNILVGEN--TLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRG 179 Query: 192 EYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Y K +DVWS G+ L+ M G P+ + F + ++ Y +P + P Sbjct: 180 HYSTK-SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR-----VDAGYRMPCPLECPPSV 233 Query: 251 RHLISRIFVADPAKRISIPEIRN 273 L+ + DP +R + +R Sbjct: 234 HKLMLTCWCRDPEQRPTFKALRE 256 >5ZTN-A nrPDB Length = 429 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 74/342 (21%), Positives = 118/342 (34%), Gaps = 65/342 (19%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 + +P H + RYE++K IG G+FG D + ++ VA+K + ++ EI Sbjct: 88 VQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL 147 Query: 70 RSLRHP------NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFF 121 LR N++ E H+ + E S L+E I FS R F Sbjct: 148 EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFA 206 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 ++ + H ++ H DLK EN LL +K+ DFG S H + + + + Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYTYIQSRF 264 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-------- 233 Y APEV+L Y G D+WS G L +L G +E I + Sbjct: 265 YRAPEVILGARY-GMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL 323 Query: 234 ----------------------------------------LNVQYAIPDYVHI-----SP 248 L ++ + P Sbjct: 324 DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDP 383 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNT 290 + + DPA R++ + H W + LP + T Sbjct: 384 LFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKT 425 >5VO2-A nrPDB Length = 300 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 73/248 (29%), Positives = 114/248 (45%), Gaps = 15/248 (6%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT 86 +GSG G L R E VAVK + ++ D I + R L+HPNI+ FK V Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD------IKHLRKLKHPNIITFKGVCTQ 71 Query: 87 PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENT 146 I+ME+ + G+L+E + + + + G++Y H ++ HRDLK N Sbjct: 72 APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNM 131 Query: 147 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVT 206 L+ +KI DFG SK S S GT A++APEV+ + K D+WS GV Sbjct: 132 LITYDDV--VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK-VDIWSFGVV 188 Query: 207 LYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 L+ +L G P++D + I + + +P + L+ + + + P R Sbjct: 189 LWELLTGEIPYKDVDSSA----IIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 244 Query: 267 SIPEIRNH 274 S +I H Sbjct: 245 SFRQILLH 252 >4O2Z-A nrPDB Length = 377 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 76/325 (23%), Positives = 128/325 (39%), Gaps = 45/325 (13%) Query: 6 VSG-PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKY---IERGEKIDEN 61 VSG P ++P +Y L+K +G G +G+A D + E V++K + R + + Sbjct: 36 VSGSPFEVPS-----KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 62 VKREIINHRSLRHPNIVR-------FKEVILTPTHLAIVMEYASGGELFERICNAGRFSE 114 V REI R H N++ K + + +V ++ + + E Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDV-DMNVVLRSRQVLEE 149 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQP 173 ++F Q++ G+ Y H+ V HRDLK N + + + LKI DFG S+S V +S+ Sbjct: 150 SHMQYFVYQILRGLKYLHSANVAHRDLKPANLV--TNISCELKIIDFGLSRSVDVPYSEL 207 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 V T Y PE+LL+ D+WS G M F R I Sbjct: 208 TDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHI 267 Query: 234 LNVQ-------------YAIPD-YVHISP---------ECRHLISRIFVADPAKRISIPE 270 +PD ++I E +S+++ DP+KR + + Sbjct: 268 GKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAAD 327 Query: 271 IRNHEWFLKNLPADLMNDNTMTTQF 295 + H + + ++ T F Sbjct: 328 MLAHPYLAHLHDEE--DEPTCPCPF 350 >2DQ7-X nrPDB Length = 283 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 112/283 (39%), Gaps = 17/283 (6%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + +L+K +G+G FG + N VA+K ++ G E+ E + L+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK 62 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVSYC 131 H +V+ V+ + + IV EY + G L + + Q+ +G++Y Sbjct: 63 HDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 121 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 189 M HRDL+ N L+ KI DFG ++ ++ + + APE L Sbjct: 122 ERMNYIHRDLRSANILVGN--GLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 179 Query: 190 KKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K +DVWS G+ L ++ G P+ + + + Y +P Sbjct: 180 YGRFTIK-SDVWSFGILLTELVTKGRVPYPGMNNREVLEQ-----VERGYRMPCPQDCPI 233 Query: 249 ECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMNDN 289 L+ + DP +R + +++ ++F P +N Sbjct: 234 SLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 276 >5G6V-A nrPDB Length = 324 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 119/289 (41%), Gaps = 33/289 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVK--YIERGEKIDENVKREIINHRSLRHPN 76 + Y + +G G + + K ++ LVA+K +E E RE+ + L+H N Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRF-SEDEARFFFQQLISGVSYCHAMQ 135 IV ++I T L +V EY +L + + + G + + F QL+ G++YCH + Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 120 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 V HRDLK +N L++ LK+ DFG ++ S+ + V T Y P++LL Sbjct: 121 VLHRDLKPQNLLINE--RGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ----------------Y 238 D+W G Y M G F + I RIL Y Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLH-FIFRILGTPTEETWPGILSNEEFKTY 237 Query: 239 AIPDY---------VHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 P Y + + L++++ + RIS + H +FL Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFL 286 >4U41-A nrPDB Length = 332 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 139/322 (43%), Gaps = 23/322 (7%) Query: 2 DRPAVS-GPMDLPIMHD-SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 D PA S +DL + D + +ELV+ +G+G +G R ++ +L A+K ++ E + Sbjct: 5 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 64 Query: 60 ENVKREIINHRSL-RHPNIVRFKEVIL------TPTHLAIVMEYASGGELFERICNAG-- 110 E +K EI + H NI + + L +VME+ G + + + N Sbjct: 65 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 124 Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 170 ED + ++++ G+++ H V HRD+K +N LL + +K+ DFG S Sbjct: 125 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRT 182 Query: 171 -SQPKSTVGTPAYIAPEVLLKKEY----DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN 225 + + +GTP ++APEV+ E +D+WSCG+T M GA P D Sbjct: 183 VGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP--- 239 Query: 226 FRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADL 285 + + I S + I V + +R S ++ H F+++ P + Sbjct: 240 -MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHP-FIRDQPNER 297 Query: 286 MNDNTMTTQFDESDQPGQSIEE 307 + D + + +E Sbjct: 298 QVRIQLKDHIDRTRKKRGEKDE 319 >4UY9-A nrPDB Length = 323 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 79/271 (29%), Positives = 120/271 (44%), Gaps = 23/271 (8%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-----ENVKREIINHRS 71 D L + IG G FG + VAVK D ENV++E Sbjct: 7 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 64 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 L+HPNI+ + V L +L +VME+A GG L R+ + R D + Q+ G++Y Sbjct: 65 LKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 132 HAMQ---VCHRDLKLENTLL-----DGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAY 182 H + HRDLK N L+ +G + ++ KI DFG ++ ++ S GT A+ Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGTYAW 182 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +APEV+ + K +DVWS GV L+ +L G PF + + + + A+P Sbjct: 183 MAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLA----VAYGVAMNKLALPI 237 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEIRN 273 L+ + DP R S I + Sbjct: 238 PSTCPEPFAKLMEDCWNPDPHSRPSFTNILD 268 >5X5O-A nrPDB Length = 310 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 77/269 (28%), Positives = 119/269 (44%), Gaps = 20/269 (7%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREII 67 G + D + ++ G G+FG + ++ VAVK + + +++E Sbjct: 4 GSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 56 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 L H NI++F VIL P + IV EYAS G L++ I + D + + Sbjct: 57 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 116 Query: 126 SGVSYCHAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 G+ Y H +V HRDLK N ++ LKICDFG S+ H+ S VGT + Sbjct: 117 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGV--LKICDFGASRFHN-HTTHMSLVGTFPW 173 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +APEV+ + D +S GV L+ ML PF+ E + + + N + IP Sbjct: 174 MAPEVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK--NERLTIP- 229 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEI 271 L+ + + AD KR S +I Sbjct: 230 -SSCPRSFAELLHQCWEADAKKRPSFKQI 257 >4P5Q-A nrPDB Length = 361 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 109/266 (40%), Gaps = 19/266 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRS 71 D+ + K +G+G FG R K ++ VA+K ++ G EK + E Sbjct: 31 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQ 90 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSY 130 HPNI+R + V+ + IV EY G L + +F+ + + + SG+ Y Sbjct: 91 FDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKY 150 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPE 186 M HRDL N L++ + K+ DFG S+ + + G + +PE Sbjct: 151 LSDMGYVHRDLAARNILINSNLV--CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPE 208 Query: 187 VLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 + +++ +DVWS G+ L+ M G P+ + + + ++ Y +P + Sbjct: 209 AIAYRKFTS-ASDVWSYGIVLWEVMSYGERPYWEMSNQD-----VIKAVDEGYRLPPPMD 262 Query: 246 ISPECRHLISRIFVADPAKRISIPEI 271 L+ + D R +I Sbjct: 263 CPAALYQLMLDCWQKDRNNRPKFEQI 288 >3DTC-A nrPDB Length = 271 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 78/271 (28%), Positives = 119/271 (43%), Gaps = 23/271 (8%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-----ENVKREIINHRS 71 D L + IG G FG + VAVK D ENV++E Sbjct: 5 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 62 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 L+HPNI+ + V L +L +VME+A GG L R+ + R D + Q+ G++Y Sbjct: 63 LKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 132 HAMQ---VCHRDLKLENTLL-----DGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAY 182 H + HRDLK N L+ +G + ++ KI DFG ++ ++ S G A+ Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGAYAW 180 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +APEV+ + K +DVWS GV L+ +L G PF + + + + A+P Sbjct: 181 MAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLA----VAYGVAMNKLALPI 235 Query: 243 YVHISPECRHLISRIFVADPAKRISIPEIRN 273 L+ + DP R S I + Sbjct: 236 PSTCPEPFAKLMEDCWNPDPHSRPSFTNILD 266 >6DBM-A nrPDB Length = 318 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 77/288 (26%), Positives = 124/288 (43%), Gaps = 29/288 (10%) Query: 7 SGPMDLPIMHDSDRY-ELVKDIGSGNFGVARLM----RDKQSNELVAVKYIER--GEKID 59 GP D + H RY + ++D+G G+FG L + + E+VAVK ++ G + Sbjct: 20 QGPGDPTVFH--KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR 77 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEA 117 K+EI R+L H +I+++K L +VMEY G L + + + Sbjct: 78 SGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS-IGLAQL 136 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 F QQ+ G++Y H+ HRDL N LLD +KI DFG +K+ + Sbjct: 137 LLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVR 194 Query: 178 ----GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA-----YP--FEDPEEPKNF 226 + APE L + ++ +DVWS GVTLY +L P F + Sbjct: 195 EDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQG 253 Query: 227 RKTIHR---ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + T+ R +L +P E HL+ + + + R + + Sbjct: 254 QMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >2J0K-A nrPDB Length = 656 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 117/263 (44%), Gaps = 18/263 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSN---ELVAVKYIER--GEKIDENVKREIINHRSLR 73 +R EL + IG G FG VA+K + + + E +E + R Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCH 132 HP+IV+ VI T + I+ME + GEL + + QL + ++Y Sbjct: 450 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLE 508 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLK 190 + + HRD+ N L+ + +K+ DFG S+ + K++ G ++APE + Sbjct: 509 SKRFVHRDIAARNVLVSATDC--VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 566 Query: 191 KEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 + + +DVW GV ++ +L+ G PF+ + I RI N + +P + P Sbjct: 567 RRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNND----VIGRIENGE-RLPMPPNCPPT 620 Query: 250 CRHLISRIFVADPAKRISIPEIR 272 L+++ + DP++R E++ Sbjct: 621 LYSLMTKCWAYDPSRRPRFTELK 643 >4AN9-A nrPDB Length = 301 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 71/265 (26%), Positives = 122/265 (46%), Gaps = 11/265 (4%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 D +E + ++G+GN GV + K S ++A K I E I + RE+ P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 68 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC-HAMQ 135 IV F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 69 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 128 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + HRD+K N L++ +K+CDFG S + VGT +Y++PE L + Sbjct: 129 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DEMANEFVGTRSYMSPERLQG-THYS 184 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 +D+WS G++L M VG YP P + + I+N S E + ++ Sbjct: 185 VQSDIWSMGLSLVEMAVGRYP----RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVN 240 Query: 256 RIFVADPAKRISIPEIRNHEWFLKN 280 + + +PA+R + ++ H + ++ Sbjct: 241 KCLIKNPAERADLKQLMVHAFIKRS 265 >4OLI-A nrPDB Length = 645 Score = 223 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 120/285 (42%), Gaps = 26/285 (9%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM----RDKQSNELVAVKYIER--GEKIDENV 62 P P + + ++D+G G+FG L + + E+VAVK ++ G + Sbjct: 343 PASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGW 402 Query: 63 KREIINHRSLRHPNIVRFKEVILT--PTHLAIVMEYASGGELFERICNAGRFSEDEARFF 120 K+EI R+L H +I+++K L +VMEY G L + + + F Sbjct: 403 KQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLF 461 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--- 177 QQ+ G++Y H+ HR+L N LLD +KI DFG +K+ + Sbjct: 462 AQQICEGMAYLHSQHYIHRNLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDG 519 Query: 178 -GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA-----YP--FEDPEEPKNFRKT 229 + APE L + ++ +DVWS GVTLY +L P F + + T Sbjct: 520 DSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 578 Query: 230 IHR---ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + R +L +P E HL+ + + + R + + Sbjct: 579 VLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 93/274 (33%), Gaps = 25/274 (9%) Query: 38 MRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEY 96 RD+ V +K ++ I + H ++ V + +V EY Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 147 Query: 97 ASGGELFERICN-AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTL-----LDG 150 G L + G QQL S +SY + H ++ N L L Sbjct: 148 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 207 Query: 151 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD-GKVADVWSCGVTLYV 209 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 208 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 264 Query: 210 MLV-GAYPFE--DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 + G P + P E ++F + HR+ + + P L S+ +P +R Sbjct: 265 ICFDGEAPLQSRSPSEKEHFYQRQHRL--PEPSCPQLAT-------LTSQCLTYEPTQRP 315 Query: 267 SIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 S I + P +L + T+ SD Sbjct: 316 SFRTILRD--LTRLQPHNLADVLTVNPDSPASDP 347 >5MJB-A nrPDB Length = 305 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 106/265 (40%), Gaps = 21/265 (7%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNE---LVAVKYIERG--EKIDENVKREIINHRSLRHPN 76 ++ + IG+G FG R K + VA+K ++ G EK + E H N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + V+ + I+ E+ L + N G+F+ + + + +G+ Y M Sbjct: 89 IIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 189 HRDL N L++ + K+ DFG S+ + + + + APE + Sbjct: 149 YVHRDLAARNILVNSNLV--CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA 206 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 +++ +DVWS G+ ++ M G P+ D + + Y +P + Sbjct: 207 YRKFTS-ASDVWSYGIVMWEVMSFGERPYWDMSNQD-----VINAIEQDYRLPPPMDCPA 260 Query: 249 ECRHLISRIFVADPAKRISIPEIRN 273 L+ + D R EI N Sbjct: 261 ALHQLMLDCWQKDRNSRPRFAEIVN 285 >3A4O-X nrPDB Length = 286 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 59/261 (22%), Positives = 107/261 (40%), Gaps = 14/261 (5%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + +LVK +G+G FG + S + VAVK ++ G + E ++L+ Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAFLEEANLMKTLQ 66 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVSYC 131 H +VR V+ + I+ EY + G L + + G+ + F Q+ G++Y Sbjct: 67 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 126 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 189 HRDL+ N L+ S KI DFG ++ ++ + + APE + Sbjct: 127 ERKNYIHRDLRAANVLVSESL--MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 184 Query: 190 KKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K +DVWS G+ LY ++ G P+ + L+ Y +P + Sbjct: 185 FGCFTIK-SDVWSFGILLYEIVTYGKIPYPGRTNAD-----VMTALSQGYRMPRVENCPD 238 Query: 249 ECRHLISRIFVADPAKRISIP 269 E ++ + +R + Sbjct: 239 ELYDIMKMCWKEKAEERPTFD 259 >4OTD-A nrPDB Length = 341 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 81/307 (26%), Positives = 140/307 (45%), Gaps = 35/307 (11%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL------ 72 + ++ + +G G+FG L + S EL A+K +++G+ + + ++ + + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 73 -RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 HP +V TP H+ VMEY++GG+L I + FSE A F+ ++ G+ + Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 130 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLK 190 H ++ +R L+ L +KI DFG K + + ST GTP ++APEVL Sbjct: 131 HEHKIVYR--DLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Y + D W GV LY MLVG PF +E + F I+N + P + +S E Sbjct: 189 TSY-TRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDS----IVNDEVRYPRF--LSAEA 241 Query: 251 RHLISRIFVADPAKRIS-----IPEIRNHEWFL---------KNLPADL---MNDNTMTT 293 ++ R+ +P +R+ +++ +F + LP ++ T + Sbjct: 242 IGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVS 301 Query: 294 QFDESDQ 300 FDE Sbjct: 302 NFDEEFT 308 >2W96-B nrPDB Length = 306 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 112/297 (37%), Gaps = 38/297 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLR- 73 + RYE V +IG G +G RD S VA+K + E + + RE+ R L Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 74 --HPNIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQL 124 HPN+VR +V T + +V E+ +L + A + + +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 + G+ + HA + HRDLK EN L+ +K+ DFG ++ V T Y A Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALDPVVVTLWYRA 179 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQYAIPDY 243 PEVLL+ Y D+WS G M F E K I L + P Sbjct: 180 PEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 238 Query: 244 VHISPEC--------------------RHLISRIFVADPAKRISIPEIRNHEWFLKN 280 V + L+ + +P KRIS H + K+ Sbjct: 239 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 295 >2I6L-A nrPDB Length = 320 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 120/319 (37%), Gaps = 47/319 (14%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI-ERGEKIDENVKREIIN 68 M++ RY +K +G G G+ D ++ VA+K I + ++ REI Sbjct: 2 MNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKI 61 Query: 69 HRSLRHPNIVRFK--------------EVILTPTHLAIVMEYASGGELFERICNAGRFSE 114 R L H NIV+ + + IV EY +L + G E Sbjct: 62 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVL-EQGPLLE 119 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 174 + AR F QL+ G+ Y H+ V HRDLK N ++ LKI DFG ++ H K Sbjct: 120 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLV-LKIGDFGLARIMDPHYSHK 178 Query: 175 ST----VGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 + T Y +P +LL K D+W+ G ML G F E + + + Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 231 HRILNVQYA--------IPDY----------------VHISPECRHLISRIFVADPAKRI 266 I V IP Y IS E + +I P R+ Sbjct: 239 ESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL 298 Query: 267 SIPEIRNHEWF-LKNLPAD 284 + E +H + + + P D Sbjct: 299 TAEEALSHPYMSIYSFPMD 317 >1JPA-A nrPDB Length = 312 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 106/265 (40%), Gaps = 21/265 (7%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRSLRHPN 76 ++ + IG+G FG K + VA+K ++ G EK + E HPN Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 ++ + V+ T + I+ E+ G L + N G+F+ + + + +G+ Y M Sbjct: 96 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMN 155 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG------TPAYIAPEVLL 189 HRDL N L++ + K+ DFG S+ + + + APE + Sbjct: 156 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 213 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 +++ +DVWS G+ ++ M G P+ D + + Y +P + Sbjct: 214 YRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMTNQD-----VINAIEQDYRLPPPMDCPS 267 Query: 249 ECRHLISRIFVADPAKRISIPEIRN 273 L+ + D R +I N Sbjct: 268 ALHQLMLDCWQKDRNHRPKFGQIVN 292 >3PG1-A nrPDB Length = 362 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/339 (21%), Positives = 125/339 (36%), Gaps = 49/339 (14%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKY------------IERGEKIDENVKREIIN 68 Y + + I SG++G D + VA+K I + + V REI Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 69 HRSLRHPNIVRFKEVILTPTH-----LAIVMEYASGGELFERICNAG-RFSEDEARFFFQ 122 HPNI+ +++ + L +V E +L + I + S ++F Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQYFMY 141 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 ++ G+ H V HRDL N LL + + ICDF ++ + V Y Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADN--NDITICDFNLAREDTADANKTHYVTHRWY 199 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ----- 237 APE++++ + K+ D+WS G + M F K + + + Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 238 -YAIP---DYVHIS-----------------PECRHLISRIFVADPAKRISIPEIRNHEW 276 ++ P DY+ S P LI+++ +P +RIS + H + Sbjct: 260 MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPY 319 Query: 277 FLKNL-PADLMNDNTMTTQFDESDQPGQSIEEIMQIIAE 314 F P DL + FDES + +I E Sbjct: 320 FESLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVE 358 >2HK5-A nrPDB Length = 270 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 114/266 (42%), Gaps = 17/266 (6%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLM-RDKQSNELVAVKYIERGEKIDENVKREIINHRSL 72 + +L K +G+G FG + +K + VAVK ++ G E E ++L Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVEAFLAEANVMKTL 67 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVSY 130 +H +V+ V+ T + I+ E+ + G L + + + + F Q+ G+++ Sbjct: 68 QHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 126 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVL 188 HRDL+ N L+ S KI DFG ++ ++ + + APE + Sbjct: 127 IEQRNYIHRDLRAANILVSASLV--CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI 184 Query: 189 LKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + K +DVWS G+ L ++ G P+ P+ + R L Y +P + Sbjct: 185 NFGSFTIK-SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCP 238 Query: 248 PECRHLISRIFVADPAKRISIPEIRN 273 E +++ R + P +R + I++ Sbjct: 239 EELYNIMMRCWKNRPEERPTFEYIQS 264 >2Y6O-A nrPDB Length = 291 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 110/268 (41%), Gaps = 19/268 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRS 71 D+ ++ K IG G FG R K + VA+K ++ G +K + E Sbjct: 12 DASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQ 71 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSY 130 HPNI+ + V+ + I+ EY G L + N GRF+ + + + SG+ Y Sbjct: 72 FDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKY 131 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPE 186 M HRDL N L++ + K+ DFG S+ + + G + APE Sbjct: 132 LSDMSYVHRDLAARNILVNSNLV--CKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 187 VLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 + +++ +DVWS G+ ++ M G P+ D + + + Y +P + Sbjct: 190 AIAYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQD-----VIKAIEEGYRLPPPMD 243 Query: 246 ISPECRHLISRIFVADPAKRISIPEIRN 273 L+ + + + R +I N Sbjct: 244 CPIALHQLMLDCWQKERSDRPKFGQIVN 271 >5L6P-A nrPDB Length = 298 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 107/265 (40%), Gaps = 21/265 (7%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRSLRHPN 76 ++ + IG+G FG R KQ VA+K ++ G E+ + E HPN Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + V+ + I+ E+ L + N G+F+ + + + +G+ Y M Sbjct: 82 IIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMN 141 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 189 HRDL N L++ + K+ DFG S+ + + + APE + Sbjct: 142 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA 199 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 +++ +DVWS G+ ++ M G P+ D + + Y +P + Sbjct: 200 YRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQD-----VINAVEQDYRLPPPMDCPT 253 Query: 249 ECRHLISRIFVADPAKRISIPEIRN 273 L+ +V D R +I N Sbjct: 254 ALHQLMLDCWVRDRNLRPKFSQIVN 278 >3DKO-A nrPDB Length = 318 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 112/266 (42%), Gaps = 19/266 (7%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRS 71 D+ ++ + IG+G FG R K + VA+K ++ G EK + E Sbjct: 41 DASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQ 100 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSY 130 HPN+V + V+ + IV+E+ G L + G+F+ + + + +G+ Y Sbjct: 101 FDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRY 160 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTP---AYIAPE 186 M HRDL N L++ + K+ DFG S+ + +T G + APE Sbjct: 161 LADMGYVHRDLAARNILVNSNLV--CKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 187 VLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 + +++ +DVWS G+ ++ M G P+ D + + + Y +P + Sbjct: 219 AIQYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQD-----VIKAIEEGYRLPAPMD 272 Query: 246 ISPECRHLISRIFVADPAKRISIPEI 271 L+ + + A+R +I Sbjct: 273 CPAGLHQLMLDCWQKERAERPKFEQI 298 >2WTK-C nrPDB Length = 305 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 88/296 (29%), Positives = 138/296 (46%), Gaps = 23/296 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-----DENVKREIINHRSLRH 74 +Y + +G G++G + + D ++ AVK +++ + + NVK+EI R LRH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 75 PNIVRFKEVI--LTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSY 130 N+++ +V+ + +VMEY G E+ + + RF +A +F QLI G+ Y Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGLEY 124 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTPAYIAPEV 187 H+ + H+D+K N LL LKI G +++ +++ G+PA+ PE+ Sbjct: 125 LHSQGIVHKDIKPGNLLLTT--GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 188 LLK-KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 + G D+WS GVTLY + G YPFE N K I YAIP Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGSYAIP--GDC 236 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPG 302 P L+ + +PAKR SI +IR H WF K P + D D+ Sbjct: 237 GPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSP-DTKDRWR 291 >2XNP-A nrPDB Length = 279 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 81/278 (29%), Positives = 130/278 (46%), Gaps = 23/278 (8%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---EKIDENVKREIINHRSLR 73 ++ YE++ IG+G++G + +R K +++ K ++ G E + + E+ R L+ Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 74 HPNIVRFKE--VILTPTHLAIVMEYASGGELFERI----CNAGRFSEDEARFFFQQLISG 127 HPNIVR+ + + T T L IVMEY GG+L I E+ QL Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 128 VSYCHA-----MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPA 181 + CH V HRDLK N LDG +K+ DFG ++ S K+ VGTP Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQ--NVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Y++PE + + Y+ K +D+WS G LY + PF + ++ +I ++ Sbjct: 182 YMSPEQMNRMSYNEK-SDIWSLGCLLYELCALMPPF----TAFSQKELAGKIREGKFRRI 236 Query: 242 DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 Y S E +I+R+ R S+ EI + L+ Sbjct: 237 PY-RYSDELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >1U54-B nrPDB Length = 291 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 24/298 (8%) Query: 5 AVSGPMD-LPIMHDSDRYELVKDIGSGNFGVARLMR-DKQSNELV--AVKYIERG----E 56 A GP+ L + L++ +G G+FGV R D S + V AVK ++ Sbjct: 3 AGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQP 62 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSED 115 + ++ RE+ SL H N++R V+LTP + +V E A G L +R+ G F Sbjct: 63 EAMDDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLG 121 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK- 174 + Q+ G+ Y + + HRDL N LL +KI DFG ++ + Sbjct: 122 TLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL--VKIGDFGLMRALPQNDDHYV 179 Query: 175 ---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTI 230 A+ APE L + + +D W GVTL+ M G P+ N + + Sbjct: 180 MQEHRKVPFAWCAPESLKTRTFSH-ASDTWMFGVTLWEMFTYGQEPWIGL----NGSQIL 234 Query: 231 HRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMND 288 H+I +P + +++ + + P R + +R+ + L+ P D+ + Sbjct: 235 HKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDMRAE 290 >4CRS-A nrPDB Length = 341 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 84/330 (25%), Positives = 145/330 (43%), Gaps = 27/330 (8%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV-------KREI 66 + + + G+FG L K +NE+ A+K +++G+ + + KR Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIF 66 Query: 67 INHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 126 S+RHP +V T H+ VMEYA+GG+L I + FSE A F+ ++ Sbjct: 67 ETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVL 125 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAP 185 G+ Y H ++ +R L+ L +KI DFG K + + ST GTP ++AP Sbjct: 126 GLQYLHEHKIVYR--DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 EVL + Y + D W GV +Y MLVG PF +E + F I+N + P + Sbjct: 184 EVLTETSY-TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDS----IVNDEVRYPRF-- 236 Query: 246 ISPECRHLISRIFVADPAKRIS-----IPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQ 300 +S E ++ R+ +P +R+ +++ H +F + + + D + F + + Sbjct: 237 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF-RLIDWSALMDKKVKPPFIPTIR 295 Query: 301 PGQSIEEIMQIIAEATV---PPAGTQNLNH 327 + + PP + L+ Sbjct: 296 GREDVSNFDDEFTSEAPILTPPREPRILSE 325 >4E93-A nrPDB Length = 377 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 102/275 (37%), Gaps = 16/275 (5%) Query: 6 VSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVK 63 + P D +++ D L + IG GNFG R + N LVAVK + Sbjct: 102 RAVPKDKWVLNHED-LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL 160 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQ 122 +E + HPNIVR V + IVME GG+ + G R Sbjct: 161 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 220 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS---TVGT 179 +G+ Y + HRDL N L+ LKI DFG S+ S Sbjct: 221 DAAAGMEYLESKCCIHRDLAARNCLVTEKNV--LKISDFGMSREEADGVYAASGGLRQVP 278 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 + APE L Y + +DVWS G+ L+ +GA P+ + + + Sbjct: 279 VKWTAPEALNYGRYSSE-SDVWSFGILLWETFSLGASPYPNLSNQQT-----REFVEKGG 332 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +P L+ + + +P +R S I Sbjct: 333 RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQ 367 >4X7Q-B nrPDB Length = 312 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 26/271 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-------EIINHRSL 72 Y L +G G FG VA+K I R + + E+ + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 73 R----HPNIVRFKEVILTPTHLAIVMEY-ASGGELFERICNAGRFSEDEARFFFQQLISG 127 HP ++R + T +V+E +LF+ I G E +R FF Q+++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + +CH+ V HRD+K EN L+D K+ DFG S + + GT Y PE Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFG-SGALLHDEPYTDFDGTRVYSPPEW 209 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + + +Y A VWS G+ LY M+ G PFE +E IL + P H+S Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE----------ILEAELHFP--AHVS 257 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFL 278 P+C LI R P+ R S+ EI W Sbjct: 258 PDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >2R2P-A nrPDB Length = 295 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 107/263 (40%), Gaps = 19/263 (7%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRSLRHPN 76 + + IG+G FG R K + VA+K ++ G EK + E HPN Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHAMQ 135 I+ + V+ + IV EY G L + G+F+ + + + +G+ Y M Sbjct: 85 IIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMG 144 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPEVLLKK 191 HRDL N L++ + K+ DFG S+ + + G + APE + + Sbjct: 145 YVHRDLAARNILINSNLV--CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFR 202 Query: 192 EYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 ++ +DVWS G+ ++ ++ G P+ + + + + Y +P + Sbjct: 203 KFTS-ASDVWSYGIVMWEVVSYGERPYWEMTNQD-----VIKAVEEGYRLPSPMDCPAAL 256 Query: 251 RHLISRIFVADPAKRISIPEIRN 273 L+ + + R EI N Sbjct: 257 YQLMLDCWQKERNSRPKFDEIVN 279 >3ALO-A nrPDB Length = 327 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 114/279 (40%), Gaps = 17/279 (6%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKIDENVKREI-INH 69 ++ + + +IG G +G M K S +++AVK I EK + + ++ + Sbjct: 16 HWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVM 75 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA------GRFSEDEARFFFQQ 123 RS P IV+F + I ME S F++ E+ Sbjct: 76 RSSDCPYIVQFYGALFREGDCWICMELMS--TSFDKFYKYVYSVLDDVIPEEILGKITLA 133 Query: 124 LISGVSYC-HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 + +++ +++ HRD+K N LLD S +K+CDFG S V G Y Sbjct: 134 TVKALNHLKENLKIIHRDIKPSNILLDRS--GNIKLCDFGISGQLVDSIAKTRDAGCRPY 191 Query: 183 IAPEVL---LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 +APE + ++ +DVWS G+TLY + G +P+ + + + Q + Sbjct: 192 MAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLS 251 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + SP + ++ D +KR E+ H + L Sbjct: 252 NSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 290 >6FEX-A nrPDB Length = 321 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 110/315 (34%), Gaps = 43/315 (13%) Query: 4 PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLM----------------RDKQSNELV 47 P G + R + +G G FG L K LV Sbjct: 1 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 60 Query: 48 AVKYIERG--EKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFER 105 AVK + + + +E+ L+ PNI+R V + L ++ +Y G+L + Sbjct: 61 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 106 ICNAG-------------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSP 152 + S Q+ SG+ Y + HRDL N L+ + Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF 180 Query: 153 APRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYV 209 +KI DFG S++ + V ++A E +L ++ +DVW+ GVTL+ Sbjct: 181 T--IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT-ASDVWAFGVTLWE 237 Query: 210 --MLVGAYPFEDPEEPKNFRKTIH--RILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 ML A PF + + R Q + L+ R + + +R Sbjct: 238 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 Query: 266 ISIPEIRNHEWFLKN 280 ++ H + ++ Sbjct: 298 PPFSQL--HRFLAED 310 >1AD5-A nrPDB Length = 438 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 117/279 (41%), Gaps = 28/279 (10%) Query: 4 PAVSGPMDLPIMHDS-----DRYELVKDIGSGNFGVARLM-RDKQSNELVAVKYIERGEK 57 P +S P D+ + +L K +G+G FG + +K + VAVK ++ G Sbjct: 162 PCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSM 219 Query: 58 IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSED 115 E E ++L+H +V+ V+ T + I+ E+ + G L + + + Sbjct: 220 SVEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 278 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 175 + F Q+ G+++ HRDL+ N L+ S KI DFG ++ Sbjct: 279 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLV--CKIADFGLARV--------G 328 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRIL 234 + APE + + K +DVWS G+ L ++ G P+ P+ + R L Sbjct: 329 AKFPIKWTAPEAINFGSFTIK-SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRAL 382 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 Y +P + E +++ R + P +R + I++ Sbjct: 383 ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 421 >3QGY-A nrPDB Length = 286 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 113/269 (42%), Gaps = 15/269 (5%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH 69 L ++ D V++IGSG FG+ L + + VA+K I+ G +++ E Sbjct: 18 GSLHMVIDPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVM 76 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGV 128 L HP +V+ V L + +V E+ G L + + G F+ + + G+ Sbjct: 77 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 136 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAP 185 +Y V HRDL N L+ + +K+ DFG ++ VL Q S+ GT + +P Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQV--IKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASP 193 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 EV Y K +DVWS GV ++ + G P+E+ + + + + Sbjct: 194 EVFSFSRYSSK-SDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI-----STGFRLYKPR 247 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRN 273 S +++ + P R + + Sbjct: 248 LASTHVYQIMNHCWKERPEDRPAFSRLLR 276 >6BSD-A nrPDB Length = 876 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 110/321 (34%), Gaps = 49/321 (15%) Query: 4 PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLM----------------RDKQSNELV 47 P G + R + +G G FG L K LV Sbjct: 556 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 615 Query: 48 AVKYIERG--EKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFER 105 AVK + + + +E+ L+ PNI+R V + L ++ +Y G+L + Sbjct: 616 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 675 Query: 106 ICNAG-------------------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENT 146 + S Q+ SG+ Y + HRDL N Sbjct: 676 LSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNC 735 Query: 147 LLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLKKEYDGKVADVWSC 203 L+ + +KI DFG S++ + V ++A E +L ++ +DVW+ Sbjct: 736 LVGENFT--IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT-ASDVWAF 792 Query: 204 GVTLYV--MLVGAYPFEDPEEPKNFRKTIH--RILNVQYAIPDYVHISPECRHLISRIFV 259 GVTL+ ML A PF + + R Q + L+ R + Sbjct: 793 GVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS 852 Query: 260 ADPAKRISIPEIRNHEWFLKN 280 + +R ++ H + ++ Sbjct: 853 RESEQRPPFSQL--HRFLAED 871 >3VN9-A nrPDB Length = 340 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 112/272 (41%), Gaps = 17/272 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIIN-HRSLRH 74 +D E + ++G G +GV MR S +++AVK I + + + ++ R++ Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFER----ICNAGRFSEDEARFFFQQLISGVSY 130 P V F + + I ME L + I ED ++ + + Sbjct: 110 PFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 Query: 131 CHAM-QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 188 H+ V HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 169 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 Query: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L ++ +D+WS G+T+ + + +P++ P K + + Q Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DKF 283 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 S E S+ + +R + PE+ H +F Sbjct: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >2VWV-A nrPDB Length = 302 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 106/263 (40%), Gaps = 21/263 (7%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--EKIDENVKREIINHRSLRHPN 76 ++ + IG+G FG R K + VA+K ++ G E+ E HPN Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPN 78 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + V+ + I+ E+ G L + N G+F+ + + + SG+ Y M Sbjct: 79 IIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMS 138 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 189 HRDL N L++ + K+ DFG S+ +S + + + APE + Sbjct: 139 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA 196 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 +++ +D WS G+ ++ M G P+ D + + Y +P Sbjct: 197 FRKFTS-ASDAWSYGIVMWEVMSFGERPYWDMSNQD-----VINAIEQDYRLPPPPDCPT 250 Query: 249 ECRHLISRIFVADPAKRISIPEI 271 L+ + D R P++ Sbjct: 251 SLHQLMLDCWQKDRNARPRFPQV 273 >3TT0-A nrPDB Length = 382 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 119/296 (40%), Gaps = 38/296 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIERG--EKID 59 P D DR L K +G G FG L +DK + VAVK ++ EK Sbjct: 59 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 118 Query: 60 ENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR------- 111 ++ E+ + + +H NI+ L +++EYAS G L E + Sbjct: 119 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSY 178 Query: 112 ---------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 S + Q+ G+ Y + + HRDL N L+ +KI DFG Sbjct: 179 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFG 236 Query: 163 YSKS-SVLHSQPKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFE 218 ++ + K+T G ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYP 295 Query: 219 DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 + F ++L + + + + E ++ + A P++R + ++ Sbjct: 296 GVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >5A46-A nrPDB Length = 386 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 123/308 (39%), Gaps = 44/308 (14%) Query: 3 RPAVSG------PMDLPIMHDSDRYELVKDIGSGNFGVARLM------RDKQSN-ELVAV 49 P ++G P D DR L K +G G FG L +DK + VAV Sbjct: 18 TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAV 77 Query: 50 KYIERG--EKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERI 106 K ++ EK ++ E+ + + +H NI+ L +++EYAS G L E + Sbjct: 78 KMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL 137 Query: 107 CNAGR----------------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDG 150 S + Q+ G+ Y + + HRDL N L+ Sbjct: 138 QARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE 197 Query: 151 SPAPRLKICDFGYSKS-SVLHSQPKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTL 207 +KI DFG ++ + K+T G ++APE L + Y + +DVWS GV L Sbjct: 198 DNV--MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLL 254 Query: 208 YVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 + + G P+ + F ++L + + + + E ++ + A P++R Sbjct: 255 WEIFTLGGSPYPGVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 309 Query: 267 SIPEIRNH 274 + ++ Sbjct: 310 TFKQLVED 317 >3V5Q-A nrPDB Length = 297 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 34/277 (12%) Query: 23 LVKDIGSGNFGVARLMR-----DKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPN 76 L +++G G FG L + LVAVK ++ ++ +RE +L+H + Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 78 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------------FSEDEARFF 120 IV+F V L +V EY G+L + + G + Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTV 177 Q+ SG+ Y + HRDL N L+ + +KI DFG S+ S+ + T+ Sbjct: 139 ASQIASGMVYLASQHFVHRDLATRNCLVGANLL--VKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNV 236 ++ PE ++ +++ + +DVWS GV L+ + G P+ + I I Sbjct: 197 LPIRWMPPESIMYRKFTTE-SDVWSFGVILWEIFTYGKQPWFQLSNT----EVIECITQG 251 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + + E ++ + +P +R++I EI Sbjct: 252 RV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK 287 >3RP9-A nrPDB Length = 458 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 83/389 (21%), Positives = 137/389 (35%), Gaps = 95/389 (24%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--- 59 +P S P DRYE+ IG+G++G DK +VA+K I R + Sbjct: 37 KPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDC 96 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSE 114 + + REI L H ++V+ ++++ L +V+E A + + +E Sbjct: 97 KRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTE 155 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV------ 168 + L+ GV Y H+ + HRDLK N L++ + +K+CDFG +++ Sbjct: 156 LHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCS--VKVCDFGLARTVDYPENGN 213 Query: 169 ----------------------LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVT 206 L Q V T Y APE++L +E + DVWS G Sbjct: 214 SQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCI 273 Query: 207 LYVMLV-----------GAYPFEDPE-------------------EPKNFRKTIHRILNV 236 +L F ++ I IL Sbjct: 274 FAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGT 333 Query: 237 QYA-----------------IP---------DYVHISPECRHLISRIFVADPAKRISIPE 270 P + S + HL+ R+ V +P KRI+I E Sbjct: 334 PSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINE 393 Query: 271 IRNHEWFLKNLPADLMNDNTMTTQFDESD 299 H +F + A++ + T + +D Sbjct: 394 CLAHPFFKEVRIAEVETNATEKVRLPFND 422 >2PL0-A nrPDB Length = 289 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 108/265 (40%), Gaps = 15/265 (5%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + +LV+ +G+G FG + + VAVK +++G + E + L+ Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQ 76 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSYC 131 H +VR V+ + I+ EY G L + + + + ++ Q+ G+++ Sbjct: 77 HQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 135 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 189 HRDL+ N L+ + + KI DFG ++ ++ + + APE + Sbjct: 136 EERNYIHRDLRAANILVSDTLS--CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 193 Query: 190 KKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K +DVWS G+ L ++ G P+ P+ + L Y + + Sbjct: 194 YGTFTIK-SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQN-----LERGYRMVRPDNCPE 247 Query: 249 ECRHLISRIFVADPAKRISIPEIRN 273 E L+ + P R + +R+ Sbjct: 248 ELYQLMRLCWKERPEDRPTFDYLRS 272 >1FVR-A nrPDB Length = 327 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 109/286 (38%), Gaps = 31/286 (10%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELV--AVKYIER--GEKIDENVKR 64 P P++ D + + IG GNFG R K+ + A+K ++ + + Sbjct: 16 PTIYPVL-DWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG 74 Query: 65 EIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG------------- 110 E+ L HPNI+ +L + +EYA G L + + + Sbjct: 75 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS 134 Query: 111 ---RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 S + F + G+ Y Q HRDL N L+ + KI DFG S+ Sbjct: 135 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA--KIADFGLSRGQ 192 Query: 168 VLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNF 226 ++ + ++A E L Y +DVWS GV L+ ++ G P+ + + Sbjct: 193 EVYVKKTMGRLPVRWMAIESLNYSVYTT-NSDVWSYGVLLWEIVSLGGTPYCGMTCAELY 251 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIR 272 K L Y + ++ E L+ + + P +R S +I Sbjct: 252 EK-----LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >4XCU-A nrPDB Length = 300 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 115/286 (40%), Gaps = 29/286 (10%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMR-------DKQSNELVAVKYIE--RGEKID 59 P+D DR L K +G G FG VAVK ++ +K Sbjct: 7 PLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL 66 Query: 60 ENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-------NAGR 111 ++ E+ + + RH NI+ V L +++E A+ G L E + + G Sbjct: 67 ADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGP 126 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 170 S Q+ G+ Y + + HRDL N L+ +KI DFG ++ + Sbjct: 127 LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--MKIADFGLARGVHHID 184 Query: 171 SQPKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFR 227 K++ G ++APE L + Y + +DVWS G+ L+ + G P+ + F Sbjct: 185 YYKKTSNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGILLWEIFTLGGSPYPGIPVEELFS 243 Query: 228 KTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +L + + H PE L+ + A P++R + ++ Sbjct: 244 -----LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >3FME-A nrPDB Length = 290 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 112/272 (41%), Gaps = 17/272 (6%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIIN-HRSLRH 74 +D E + ++G G +GV MR S +++AVK I + + + ++ R++ Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 65 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFER----ICNAGRFSEDEARFFFQQLISGVSY 130 P V F + + I ME L + I ED ++ + + Sbjct: 66 PFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 131 CHAM-QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 188 H+ V HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 125 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L ++ +D+WS G+T+ + + +P++ P K + + Q Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DKF 239 Query: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 S E S+ + +R + PE+ H +F Sbjct: 240 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >6GVJ-A nrPDB Length = 429 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 122/290 (42%), Gaps = 29/290 (10%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV---KREIINHRSL--RHP 75 Y ++K IGSG + + + ++ A+KY+ E ++ + + EI L Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 205 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 263 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLKKE 192 + H DLK N L+ LK+ DFG + + S VGT Y+ PE + Sbjct: 264 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 193 YD----------GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +DVWS G LY M G PF+ + N +H I++ + I + Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---QIINQISKLHAIIDPNHEI-E 376 Query: 243 YVHISP-ECRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I + + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 377 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 426 >3E3P-A nrPDB Length = 360 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 125/328 (38%), Gaps = 40/328 (12%) Query: 6 VSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKRE 65 + D + DR+++ + G G FG +L ++K + VA+K + + + + Sbjct: 10 AAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQI 69 Query: 66 IINHRSLRHPNIVRFKEVILT-------PTHLAIVMEYAS---GGELFERICNAGRFSED 115 + + L HPNIV+ + T +L +VMEY Sbjct: 70 MQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPI 129 Query: 116 EARFFFQQLISGVSYCH--AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 173 + F QLI + H ++ VCHRD+K N L++ + LK+CDFG +K Sbjct: 130 LIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEAD-GTLKLCDFGSAKKLSPSEPN 188 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH-- 231 + + + Y APE++ ++ D+WS G M++G F + + Sbjct: 189 VAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVL 248 Query: 232 --------RILNVQYA---------IPDYVHISP-------ECRHLISRIFVADPAKRIS 267 R LN + IP S E L+S + P +R+ Sbjct: 249 GCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMK 308 Query: 268 IPEIRNHEWFLKNL-PADLMNDNTMTTQ 294 E H +F + PA + +N + Sbjct: 309 PYEALCHPYFDELHDPATKLPNNKDLPE 336 >2PSQ-A nrPDB Length = 370 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 123/309 (39%), Gaps = 44/309 (14%) Query: 2 DRPAVSG------PMDLPIMHDSDRYELVKDIGSGNFGVARLM----RDKQSNEL---VA 48 D P ++G P D D+ L K +G G FG + DK + VA Sbjct: 58 DTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVA 117 Query: 49 VKYIERG--EKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFER 105 VK ++ EK ++ E+ + + +H NI+ L +++EYAS G L E Sbjct: 118 VKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREY 177 Query: 106 ICNAGR----------------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLD 149 + + + QL G+ Y + + HRDL N L+ Sbjct: 178 LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 237 Query: 150 GSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVT 206 + +KI DFG ++ + + + + ++APE L + Y + +DVWS GV Sbjct: 238 ENNV--MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVL 294 Query: 207 LYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 ++ + G P+ + F ++L + + + + E ++ + A P++R Sbjct: 295 MWEIFTLGGSPYPGIPVEELF-----KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 349 Query: 266 ISIPEIRNH 274 + ++ Sbjct: 350 PTFKQLVED 358 >5O0Y-A nrPDB Length = 579 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 110/283 (38%), Gaps = 23/283 (8%) Query: 32 FGVARLMRDKQSNELVAVKYI--------ERGEKIDENVKREIINHRSLRHPNIVRFKEV 83 F D VAVK E+ E ++ RE H+ L HP IV+ + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 84 I-LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ--VCHRD 140 L V+EY G +L + SE EAR Q+++ + Y + ++ + H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 141 LKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST--------VGTPAYIAPEVLLKK 191 LK N LL +G+ +KI DFG SK S GT Y+ PE + Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 192 EYDGK---VADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + K DVWS GV Y L G PF + ++ + + + P ++P Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 249 ECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTM 291 E + I R RI + ++ + L ++ + + Sbjct: 537 EAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPA 579 >5O2B-A nrPDB Length = 285 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 123/267 (46%), Gaps = 22/267 (8%) Query: 26 DIGSGNFGVARLMRDKQSNELVAV-----KYIERGEKIDENVKREIINHRSLRHPNIVRF 80 ++G G F D ++ VA + + + E+ + K E + L+HPNIVRF Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ--QRFKEEAEMLKGLQHPNIVRF 80 Query: 81 KEVILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 + + + +V E + G L + R + +Q++ G+ + H Sbjct: 81 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + +E+ Sbjct: 141 PIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE--MYEEHY 196 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEE-PKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 + DV++ G+ + M YP+ + + + +RK I + PE + + Sbjct: 197 DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN----KVTDPEVKEI 252 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKN 280 I + ++R+SI ++ NH +F ++ Sbjct: 253 IEGCIRQNKSERLSIRDLLNHAFFAED 279 >4E20-A nrPDB Length = 290 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 72/281 (25%), Positives = 119/281 (42%), Gaps = 26/281 (9%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLM----RDKQSNELVAVKYIERG--EKIDENVKREI 66 P + + ++D+G G+FG L + + E+VAVK ++ G ++ +REI Sbjct: 2 PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREI 61 Query: 67 INHRSLRHPNIVRFKEVILT--PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL 124 R+L H +IV++K + +VMEY G L + + + F QQ+ Sbjct: 62 EILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQI 120 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTP 180 G++Y HA HR L N LLD +KI DFG +K+ + Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDGDSPV 178 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG----AYP---FEDPEEPKNFRKTIHR- 232 + APE L + ++ +DVWS GVTLY +L P F + + T+ R Sbjct: 179 FWYAPECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRL 237 Query: 233 --ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L +P E HL+ + + + R + + Sbjct: 238 TELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >4PDO-A nrPDB Length = 299 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 20/259 (7%) Query: 25 KDIGSGNFGVARLMRDK-QSNEL---VAVKYIERG--EKIDENVKREIINHRSLRHPNIV 78 K IG+G FG K S + VA+K ++ G EK + E H NI+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 79 RFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYCHAMQVC 137 R + VI + I+ EY G L + + G FS + + + +G+ Y M Sbjct: 100 RLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYV 159 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLKKEY 193 HRDL N L++ + K+ DFG S+ + T + APE + +++ Sbjct: 160 HRDLAARNILVNSNLV--CKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF 217 Query: 194 DGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 +DVWS G+ ++ M G P+ + + + + +N + +P + Sbjct: 218 TS-ASDVWSFGIVMWEVMTYGERPYWELSNHE-----VMKAINDGFRLPTPMDCPSAIYQ 271 Query: 253 LISRIFVADPAKRISIPEI 271 L+ + + + A+R +I Sbjct: 272 LMMQCWQQERARRPKFADI 290 >3GQL-A nrPDB Length = 326 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 119/296 (40%), Gaps = 38/296 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIERG--EKID 59 P D DR L K +G G FG L +DK + VAVK ++ EK Sbjct: 18 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 77 Query: 60 ENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR------- 111 ++ E+ + + +H NI+ L +++EYAS G L E + Sbjct: 78 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 137 Query: 112 ---------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 S + Q+ G+ Y + + HRDL N L+ +KI DFG Sbjct: 138 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFG 195 Query: 163 YSKS-SVLHSQPKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFE 218 ++ + K+T G ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 196 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYP 254 Query: 219 DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 + F ++L + + + + E ++ + A P++R + ++ Sbjct: 255 GVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >6DBN-A nrPDB Length = 316 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 126/284 (44%), Gaps = 26/284 (9%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMR----DKQSNELVAVKYIERGEKIDE--NVKREI 66 P + + ++D+G G+FG L R + E VAVK ++ + ++K+EI Sbjct: 29 PTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEI 88 Query: 67 INHRSLRHPNIVRFKEVILTP--THLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQ 123 R+L H NIV++K + + ++ME+ G L E + N + + + + Q Sbjct: 89 EILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQ 148 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 180 + G+ Y + Q HRDL N L++ ++KI DFG +K+ + + Sbjct: 149 ICKGMDYLGSRQYVHRDLAARNVLVESE--HQVKIGDFGLTKAIETDKEYYTVKDDRDSP 206 Query: 181 -AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGA----YP---FEDPEEPKNFRKTIHR 232 + APE L++ ++ +DVWS GVTL+ +L P F P + + T+ R Sbjct: 207 VFWYAPECLMQSKFYI-ASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTR 265 Query: 233 I---LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + L +P + E L+ + + P+ R S + Sbjct: 266 LVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >4PWN-A nrPDB Length = 274 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 118/266 (44%), Gaps = 21/266 (7%) Query: 26 DIGSGNFGVARLMRDKQSNELVAV-----KYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +IG G+F D ++ VA + + + E+ + K E + L+HPNIVRF Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER--QRFKEEAEMLKGLQHPNIVRF 74 Query: 81 KEVILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 + + + +V E + G L + R + +Q++ G+ + H Sbjct: 75 YDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 + HRDLK +N + G P +KI D G + S KS +GTP ++APE + +E Sbjct: 135 PIIHRDLKCDNIFITG-PTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE--MYEEKY 191 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS-PECRHL 253 + DV++ G+ + M YP+ + + + + + + ++ PE + + Sbjct: 192 DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPA----SFDKVAIPEVKEI 247 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLK 279 I + +R SI ++ NH +F + Sbjct: 248 IEGCIRQNKDERYSIKDLLNHAFFQE 273 >5KKR-C nrPDB Length = 395 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 126/303 (41%), Gaps = 45/303 (14%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 D +E + ++G+GN GV + K S ++A K I E I + RE+ P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 127 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC-HAMQ 135 IV F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 128 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 187 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + HRD+K N L++ +K+CDFG S + S S VGT +Y++PE L + Sbjct: 188 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG-THYS 243 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPE---------------------------------- 221 +D+WS G++L M VG YP P+ Sbjct: 244 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 303 Query: 222 ----EPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 P + + I+N S E + +++ + +PA+R + ++ H + Sbjct: 304 MDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 363 Query: 278 LKN 280 ++ Sbjct: 364 KRS 366 >3KUL-B nrPDB Length = 325 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 115/281 (40%), Gaps = 20/281 (7%) Query: 2 DRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL---VAVKYIERG--E 56 + P +G ++ R + K IGSG+ G R + + VA+K ++ G E Sbjct: 33 EEPGRAG-RSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE 91 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSED 115 + + E HPNI+R + V+ IV EY G L + + G+F+ Sbjct: 92 RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIM 151 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQP 173 + + + +G+ Y + HRDL N L+D + K+ DFG S+ + Sbjct: 152 QLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLV--CKVSDFGLSRVLEDDPDAAY 209 Query: 174 KSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTI 230 +T G + APE + + + +DVWS GV ++ + G P+ + + + Sbjct: 210 TTTGGKIPIRWTAPEAIAFRTFSS-ASDVWSFGVVMWEVLAYGERPYWNMTN-----RDV 263 Query: 231 HRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + Y +P + L+ + D A+R +I Sbjct: 264 ISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQI 304 >3DLS-A nrPDB Length = 335 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 78/272 (28%), Positives = 125/272 (45%), Gaps = 24/272 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE---------NVKREIIN 68 S +Y + +GSG FG DK+ N+ V VK+I++ + +++ V EI Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVME-YASGGELFERICNAGRFSEDEARFFFQQLISG 127 + H NI++ ++ +VME + SG +LF I R E A + F+QL+S Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 V Y + HRD+K EN ++ +K+ DFG + + GT Y APEV Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFT--IKLIDFGSAAYLERGKLFYTFCGTIEYCAPEV 200 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 L+ Y G ++WS GVTLY ++ PF + EE V+ AI +S Sbjct: 201 LMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEE------------TVEAAIHPPYLVS 248 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 E L+S + P +R ++ ++ W + Sbjct: 249 KELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >4AT3-A nrPDB Length = 299 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 117/282 (41%), Gaps = 32/282 (11%) Query: 8 GPMDLPIMHDSDR-YELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIE-RGEKIDE 60 G MD + H L +++G G FG L +Q LVAVK ++ + + Sbjct: 1 GAMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK 60 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--------- 111 + RE +L+H +IV+F V + L +V EY G+L + + G Sbjct: 61 DFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN 120 Query: 112 ----FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK-- 165 ++ + QQ+ +G+ Y + HRDL N L+ + +KI DFG S+ Sbjct: 121 PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL--VKIGDFGMSRDV 178 Query: 166 -SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEP 223 S+ + T+ ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 179 YSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE-SDVWSLGVVLWEIFTYGKQPWYQLSN- 236 Query: 224 KNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 + I I + + E L+ + +P R Sbjct: 237 ---NEVIECITQGRV-LQRPRTCPQEVYELMLGCWQREPHMR 274 >4EQM-A nrPDB Length = 294 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 83/264 (31%), Positives = 121/264 (45%), Gaps = 11/264 (4%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI----ERGEKIDENVKREIINHRSLR 73 ++RY++V +G G L D N VA+K I E+ + +RE+ N L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 H NIV +V +VMEY G L E I + G S D A F Q++ G+ + H Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHD 129 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLLKK 191 M++ HRD+K +N L+D + LKI DFG +K+ S Q +GT Y +PE K Sbjct: 130 MRIVHRDIKPQNILIDSNKT--LKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAKG 186 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 E + D++S G+ LY MLVG PF K I + I Sbjct: 187 EATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSV-PNVTTDVRKDIPQSLS 245 Query: 252 HLISRIFVADPAKRI-SIPEIRNH 274 ++I R D A R +I E+++ Sbjct: 246 NVILRATEKDKANRYKTIQEMKDD 269 >3SXS-A nrPDB Length = 268 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 68/261 (26%), Positives = 119/261 (45%), Gaps = 17/261 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNEL-VAVKYIERGEKIDENVKREIINHRSLRHPNI 77 + L+K++GSG FGV +L + K + VAVK I+ G ++ +E L HP + Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKL 65 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQV 136 V+F V + IV EY S G L + + G+ + + G+++ + Q Sbjct: 66 VKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQF 125 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEY 193 HRDL N L+D +K+ DFG ++ VL Q S+VGT + APEV +Y Sbjct: 126 IHRDLAARNCLVDRDLC--VKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 194 DGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 K +DVW+ G+ ++ + G P++ + K ++ + + S Sbjct: 183 SSK-SDVWAFGILMWEVFSLGKMPYDLYTNSEVVLK-----VSQGHRLYRPHLASDTIYQ 236 Query: 253 LISRIFVADPAKRISIPEIRN 273 ++ + P KR + ++ + Sbjct: 237 IMYSCWHELPEKRPTFQQLLS 257 >3EQC-A nrPDB Length = 360 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 126/303 (41%), Gaps = 45/303 (14%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 D +E + ++G+GN GV + K S ++A K I E I + RE+ P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 92 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC-HAMQ 135 IV F + ++I ME+ GG L + + AGR E +I G++Y + Sbjct: 93 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 152 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + HRD+K N L++ +K+CDFG S + S S VGT +Y++PE L + Sbjct: 153 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQG-THYS 208 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPE---------------------------------- 221 +D+WS G++L M VG YP P+ Sbjct: 209 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFG 268 Query: 222 ----EPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 P + + I+N S E + +++ + +PA+R + ++ H + Sbjct: 269 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 328 Query: 278 LKN 280 ++ Sbjct: 329 KRS 331 >5KMM-A nrPDB Length = 329 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 37/276 (13%) Query: 23 LVKDIGSGNFGVARLMRDK-----QSNELVAVKYIER-GEKIDENVKREIINHRSLRHPN 76 L ++G G FG L Q LVAVK ++ E ++ +RE L+H + Sbjct: 39 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 98 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNA---------------GRFSEDEARFFF 121 IVRF V L +V EY G+L + + G + Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP- 180 Q+ +G+ Y + HRDL N L+ +KI DFG S+ ++S VG Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVG--QGLVVKIGDFGMSR--DIYSTDYYRVGGRT 214 Query: 181 ----AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILN 235 ++ PE +L +++ + +DVWS GV L+ + G P+ + + Sbjct: 215 MLPIRWMPPESILYRKFTTE-SDVWSFGVVLWEIFTYGKQPWYQLSNTEAID-----CIT 268 Query: 236 VQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + PE ++ + +P +R SI ++ Sbjct: 269 QGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 304 >4Y93-A nrPDB Length = 446 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 112/276 (40%), Gaps = 17/276 (6%) Query: 4 PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-VAVKYIERGEKIDENV 62 P+ +G D +K++G+G FGV + K + VA+K I+ G ++ Sbjct: 173 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSEDEF 230 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFF 121 E +L H +V+ V + I+ EY + G L + RF + Sbjct: 231 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMC 290 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP- 180 + + + Y + Q HRDL N L++ +K+ DFG ++ VL + S+ G+ Sbjct: 291 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGMTR-YVLDDEYTSSTGSKF 347 Query: 181 --AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQ 237 + +PEVL+ ++ K +D+W+ GV ++ + G P+E + Sbjct: 348 PVKWASPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQ-----G 401 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +P S ++ + +R + + + Sbjct: 402 LRLPRPHLASERVYAIMYSCWHEKADERPTFKILLS 437 >3ORP-A nrPDB Length = 311 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 70/273 (25%), Positives = 114/273 (41%), Gaps = 24/273 (8%) Query: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE----RGEKIDENVKREIINHRS 71 H SDRYEL + +G G L RD + + VAVK + R +RE N + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 72 LRHPNIVRFKEVILTPTH----LAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 L HP IV + T IVMEY G L + + G + A Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS----QPKSTVGTPAYI 183 +++ H + HRD+K N ++ + A +K+ DFG +++ Q + +GT Y+ Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNA--VKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD- 242 +PE D + +DV+S G LY +L G PF + + + IP Sbjct: 187 SPEQARGDSVDAR-SDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR-----EDPIPPS 240 Query: 243 --YVHISPECRHLISRIFVADPAKRI-SIPEIR 272 + +S + ++ + +P R + E+R Sbjct: 241 ARHEGLSADLDAVVLKALAKNPENRYQTAAEMR 273 >6O6Q-A nrPDB Length = 335 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 124/297 (41%), Gaps = 40/297 (13%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-R 73 + + YE+++ +G G + L D + E V +K ++ ++ + +KREI ++L Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKR--KKIKREISILKNLVD 94 Query: 74 HPNIVRFKEVILTPTHLA--IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 PNI+ +V+ P ++ E+ + + F++ + RF+ +L+ + Y Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYELLKALDYS 151 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H+M + HRD+K N ++D L++ D+G ++ ++ V + + PE+L+ Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKL-LRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ-------------- 237 D+WS G L M+ PF + + I R+L + Sbjct: 211 RLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLG 270 Query: 238 --------YAIPDYVH---------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 Y +V +S E LI R+ D +R++ E H +F Sbjct: 271 EEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >3N9X-A nrPDB Length = 432 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 130/348 (37%), Gaps = 87/348 (25%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID---ENVKREIINHRS 71 +H D Y + IG G++G L DK + + VA+K + R + + + REI Sbjct: 22 VHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNR 81 Query: 72 LRHPNIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 126 L+ I+R ++I+ L IV+E A +L + +E+ + L+ Sbjct: 82 LKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLL 140 Query: 127 GVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS------------------- 167 G ++ H + HRDLK N LL+ + +K+CDFG +++ Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCS--VKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 168 ----VLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV----------- 212 L Q S V T Y APE++L +E K D+WS G +L Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTN 258 Query: 213 ------GAY-------------------------------PFEDPEEPKNFRKTIHRILN 235 G+ P ED + N + I I Sbjct: 259 RFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKL 318 Query: 236 VQYAIP-----DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + P Y IS + +L+ + +P KRI+I + +H + Sbjct: 319 FPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLK 366 >3EB0-A nrPDB Length = 383 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 120/324 (37%), Gaps = 68/324 (20%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 S +Y L K +G+G+FG+ + D +S + A+K + + + RE+ + L H NI Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---RELDIMKVLDHVNI 62 Query: 78 VRFKEVILT--------------------------------------PTHLAIVMEYAS- 98 ++ + T +L ++MEY Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 99 --GGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRL 156 L I + + + QL V + H++ +CHRD+K +N L++ L Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT-L 181 Query: 157 KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYP 216 K+CDFG +K + + + + Y APE++L D+WS G +++G Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPL 241 Query: 217 FEDPEEPKNFRKTIHRILNV-------------QYAIP-----DYVHISPE-----CRHL 253 F + I + + P D+ I PE L Sbjct: 242 FSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDL 301 Query: 254 ISRIFVADPAKRISIPEIRNHEWF 277 + +I +P RI+ E H +F Sbjct: 302 LEQILRYEPDLRINPYEAMAHPFF 325 >1ZXE-A nrPDB Length = 303 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 123/294 (41%), Gaps = 37/294 (12%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + + +E + +G G FG R+ + A+K I E+ + E++ SL Sbjct: 1 SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLN 60 Query: 74 HPNIVRFKEVILT-------------PTHLAIVMEYASGGELFERICNAGRFSE-DEARF 119 H +VR+ L + L I MEY L++ I + + DE Sbjct: 61 HQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR 120 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV----------- 168 F+Q++ +SY H+ + HR+LK N +D S +KI DFG +K+ Sbjct: 121 LFRQILEALSYIHSQGIIHRNLKPMNIFIDESR--NVKIGDFGLAKNVHRSLDILKLDSQ 178 Query: 169 ----LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK 224 S +GT Y+A EVL + + D++S G+ + M+ YPF E Sbjct: 179 NLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERV 235 Query: 225 NFRKTIHRILNVQYAIPDYVHISPEC-RHLISRIFVADPAKRISIPEIRNHEWF 277 N K + R +++++ PD+ + + +I + DP KR + N W Sbjct: 236 NILKKL-RSVSIEFP-PDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >3HMP-A nrPDB Length = 342 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 129/318 (40%), Gaps = 37/318 (11%) Query: 1 MDRPAVSGPMDLPIMHDSDR--------YELVKDIGSGNFGVARLMRDKQSNELVAVKYI 52 MD P + D ++ Y ++K IGSG + + + ++ A+KY+ Sbjct: 30 MDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYV 88 Query: 53 ERGEKIDENV---KREIINHRSL--RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC 107 E ++ + + EI L I+R + +T ++ +VME +L + Sbjct: 89 NLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLK 147 Query: 108 NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 E + +++ ++ V H + H DLK N L+ LK+ DFG + Sbjct: 148 KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQM 204 Query: 168 VLHSQ---PKSTVGTPAYIAPEVLLKKEYD----------GKVADVWSCGVTLYVMLVGA 214 + S VGT Y+ PE + +DVWS G LY M G Sbjct: 205 QPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGK 264 Query: 215 YPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP-ECRHLISRIFVADPAKRISIPEIRN 273 PF+ + N +H I++ + I ++ I + + ++ DP +RISIPE+ Sbjct: 265 TPFQ---QIINQISKLHAIIDPNHEI-EFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 320 Query: 274 HEWF-LKNLPADLMNDNT 290 H + ++ P + M T Sbjct: 321 HPYVQIQTHPVNQMAKGT 338 >5HVK-A nrPDB Length = 315 Score = 210 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 134/308 (43%), Gaps = 30/308 (9%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER-GEKIDENVKREIINHR 70 + + +G G FG A + +++ E++ +K + R E+ +E+ R Sbjct: 7 PHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR 66 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVS 129 L HPN+++F V+ L + EY GG L I + ++ + F + + SG++ Sbjct: 67 CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMA 126 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH---------------SQPK 174 Y H+M + HR+L N L+ + + + DFG ++ V + Sbjct: 127 YLHSMNIIHRNLNSHNCLVRENK--NVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRY 184 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 + VG P ++APE++ + YD K DV+S G+ L ++ G +P +T+ L Sbjct: 185 TVVGNPYWMAPEMINGRSYDEK-VDVFSFGIVLCEII-GRV----NADPDYLPRTMDFGL 238 Query: 235 NVQYAIPDY--VHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT 292 NV+ + Y + P + R DP KR S + H +L+ L L + Sbjct: 239 NVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVK-LEH--WLETLRMHLAGHLPLG 295 Query: 293 TQFDESDQ 300 Q ++ D+ Sbjct: 296 PQLEQLDR 303 >6GQK-A nrPDB Length = 328 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 103/294 (35%), Gaps = 35/294 (11%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDEN-- 61 P D +R K +G+G FG + VAVK ++ E Sbjct: 31 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREA 90 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--------- 111 + E+ L H NIV ++ EY G+L + Sbjct: 91 LMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAP 150 Query: 112 -------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS 164 + + F Q+ G+++ + HRDL N LL KICDFG + Sbjct: 151 EDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT--KICDFGLA 208 Query: 165 KSSVLHS---QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDP 220 + S + ++APE + Y + +DVWS G+ L+ + G+ P+ Sbjct: 209 RDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFE-SDVWSYGIFLWELFSLGSSPYPGM 267 Query: 221 EEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 F K ++ + + + E ++ + ADP KR + +I Sbjct: 268 PVDSKFYK----MIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >2W1I-A nrPDB Length = 326 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 121/282 (42%), Gaps = 26/282 (9%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMRDK----QSNELVAVKYIERG-EKIDENVKREII 67 P + + ++ +G GNFG + R + E+VAVK ++ E+ + +REI Sbjct: 35 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 94 Query: 68 NHRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQL 124 +SL+H NIV++K V + +L ++MEY G L + + R + + Q+ Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 154 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTP 180 G+ Y + HRDL N L++ R+KI DFG +K + Sbjct: 155 CKGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 212 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG-----AYPFE------DPEEPKNFRKT 229 + APE L + ++ +DVWS GV LY + + P E + ++ + Sbjct: 213 FWYAPESLTESKFSV-ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFH 271 Query: 230 IHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + +L +P E +++ + + +R S ++ Sbjct: 272 LIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >5AMN-A nrPDB Length = 299 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 111/282 (39%), Gaps = 29/282 (10%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDE--NVK 63 D L K +G G FG + + VAVK ++ E ++ Sbjct: 15 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 74 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------FS 113 E + + HP++++ L +++EYA G L + + + + Sbjct: 75 SEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALT 134 Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQ 172 + F Q+ G+ Y M++ HRDL N L+ ++KI DFG S+ S Sbjct: 135 MGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE--GRKMKISDFGLSRDVYEEDSY 192 Query: 173 PKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKT 229 K + G ++A E L Y + +DVWS GV L+ ++ G P+ + F Sbjct: 193 VKRSQGRIPVKWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGNPYPGIPPERLFN-- 249 Query: 230 IHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L + + + S E L+ + + +P KR +I Sbjct: 250 ---LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >2ZMD-A nrPDB Length = 390 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 128/318 (40%), Gaps = 37/318 (11%) Query: 1 MDRPAVSGPMDLPIMHDSDR--------YELVKDIGSGNFGVARLMRDKQSNELVAVKYI 52 MD P + D ++ Y ++K IGSG + + + ++ A+KY+ Sbjct: 30 MDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYV 88 Query: 53 ERGEKIDENV---KREIINHRSL--RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC 107 E ++ + + EI L I+R + +T ++ +VME +L + Sbjct: 89 NLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLK 147 Query: 108 NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 E + +++ ++ V H + H DLK N L+ LK+ DFG + Sbjct: 148 KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI---VDGMLKLIDFGIANQM 204 Query: 168 VLHSQ---PKSTVGTPAYIAPEVLLKKEYD----------GKVADVWSCGVTLYVMLVGA 214 + S VG Y+ PE + +DVWS G LY M G Sbjct: 205 QPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGK 264 Query: 215 YPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP-ECRHLISRIFVADPAKRISIPEIRN 273 PF+ + N +H I++ + I ++ I + + ++ DP +RISIPE+ Sbjct: 265 TPFQ---QIINQISKLHAIIDPNHEI-EFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 320 Query: 274 HEWF-LKNLPADLMNDNT 290 H + ++ P + M T Sbjct: 321 HPYVQIQTHPVNQMAKGT 338 >5AP3-A nrPDB Length = 313 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 122/290 (42%), Gaps = 29/290 (10%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV---KREIINHRSL--RHP 75 Y ++K IGSG + + + ++ A+KY+ E ++ + + EI L Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 I+R + +T ++ +VME +L + E + +++ ++ V H Sbjct: 89 KIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 147 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLKKE 192 + H DLK N L+ LK+ DFG + + S VGT Y+ PE + Sbjct: 148 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 204 Query: 193 YD----------GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +DVWS G LY M G PF+ + N +H I++ + I + Sbjct: 205 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---QIINQISKLHAIIDPNHEI-E 260 Query: 243 YVHISP-ECRHLISRIFVADPAKRISIPEIRNHEWF-LKNLPADLMNDNT 290 + I + + ++ DP +RISIPE+ H + ++ P + M T Sbjct: 261 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 310 >4XI2-A nrPDB Length = 446 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 113/278 (40%), Gaps = 17/278 (6%) Query: 2 DRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-VAVKYIERGEKIDE 60 + P+ +G D +K++G+G FGV + K + VA+K I G ++ Sbjct: 170 NAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIREGSMSED 227 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARF 119 E +L H +V+ V + I+ EY + G L + RF + Sbjct: 228 EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLE 287 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 + + + Y + Q HRDL N L++ +K+ DFG S+ VL + S+VG+ Sbjct: 288 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGS 344 Query: 180 P---AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILN 235 + PEVL+ ++ K +D+W+ GV ++ + G P+E + + Sbjct: 345 KFPVRWSPPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 403 Query: 236 VQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + + S ++ + +R S + + Sbjct: 404 YRPHL-----ASERVYTIMYSCWHEKADERPSFKILLS 436 >6FER-A nrPDB Length = 309 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 109/295 (36%), Gaps = 40/295 (13%) Query: 21 YELVKDIGSGNFGVARLMR--------------DKQSNE--LVAVKYIERG--EKIDENV 62 + +G G FG L D +N+ LVAVK + + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------F 112 +EI L+ PNI+ V +T L ++ EY G+L + + Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTV 130 Query: 113 SEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 172 S +F Q+ SG+ Y ++ HRDL N L+ + +KI DFG S++ Sbjct: 131 SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYT--IKIADFGMSRNLYSGDY 188 Query: 173 PK---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYV--MLVGAYPFEDPEEPKNFR 227 + V +++ E +L ++ +DVW+ GVTL+ P+ + + Sbjct: 189 YRIQGRAVLPIRWMSWESILLGKFTT-ASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 Query: 228 KTIH--RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 T R Q +P L+ + D R S EI H L+ Sbjct: 248 NTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI--HLLLLQQ 300 >4KIK-B nrPDB Length = 677 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 84/379 (22%), Positives = 152/379 (40%), Gaps = 52/379 (13%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKIDENVKREIINHRSLRHPNIV 78 +E+ + +G+G FG ++++ E +A+K + + E EI R L HPN+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 79 RFKEVILTPTHLA------IVMEYASGGELFERIC---NAGRFSEDEARFFFQQLISGVS 129 ++V +LA + MEY GG+L + + N E + S + Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H ++ HRDLK EN +L + KI D GY+K S S VGT Y+APE+L Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR--------------IL 234 +++Y D WS G + + G PF +P + + + + Sbjct: 201 EQQKYTV-TVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 235 NVQYAIPDYVHISPECRHLISR----IFVADPAKRIS------------IPEIRNHEWFL 278 ++P +++ + + + + P +R + + +I N L Sbjct: 260 KFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILN----L 315 Query: 279 KNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDD 338 K + M T+ T D+ QS++ +I + +P + L + Sbjct: 316 KLVHILNMVTGTIHTYPVTEDESLQSLKA--RIQQDTGIPEEDQELLQEAGLALIPDKPA 373 Query: 339 MEEDLESDLDD---LDIDS 354 + + L++ LD+D Sbjct: 374 TQCISDGKLNEGHTLDMDL 392 >5EG3-A nrPDB Length = 334 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 119/307 (38%), Gaps = 44/307 (14%) Query: 4 PAVSG------PMDLPIMHDSDRYELVKDIGSGNFGVARLM----RDKQSNEL---VAVK 50 P ++G P D D+ L K +G G FG + DK + VAVK Sbjct: 14 PMLAGVSEFELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVK 73 Query: 51 YIERG--EKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC 107 ++ EK ++ E+ + + +H NI+ L +++ YAS G L E + Sbjct: 74 MLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLR 133 Query: 108 NAGR----------------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGS 151 + + QL G+ Y + + HRDL N L+ + Sbjct: 134 ARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 193 Query: 152 PAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLKKEYDGKVADVWSCGVTLY 208 +KI DFG ++ K T ++APE L + Y + +DVWS GV ++ Sbjct: 194 NV--MKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMW 250 Query: 209 VMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRIS 267 + G P+ + F ++L + + + + E ++ + A P++R + Sbjct: 251 EIFTLGGSPYPGIPVEELF-----KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 305 Query: 268 IPEIRNH 274 ++ Sbjct: 306 FKQLVED 312 >1K9A-A nrPDB Length = 450 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 104/261 (39%), Gaps = 17/261 (6%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 + +L++ IG G FG L + VAVK I + + + E LRH N Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-KNDATAQAFLAEASVMTQLRHSN 247 Query: 77 IVRFKEVI-LTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHA 133 +V+ VI L IV EY + G L + + + GR D F + + Y Sbjct: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 HRDL N L+ K+ DFG +K + + APE L +K++ Sbjct: 308 NNFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKKF 363 Query: 194 DGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 K +DVWS G+ L+ + G P+ P+ K + + Y + P Sbjct: 364 STK-SDVWSFGILLWEIYSFGRVPY-----PRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 Query: 253 LISRIFVADPAKRISIPEIRN 273 ++ + D A R + ++R Sbjct: 418 VMKNCWHLDAATRPTFLQLRE 438 >4XUF-A nrPDB Length = 297 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 109/296 (36%), Gaps = 42/296 (14%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRD---KQSNE--LVAVKYIERGEKIDEN--VK 63 DL + E K +GSG FG ++ VAVK ++ E + Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 60 Query: 64 REIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARF-- 119 E+ L H NIV + ++ EY G+L + +FSEDE + Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 120 Query: 120 --------------------FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC 159 F Q+ G+ + HRDL N L+ +KIC Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH--GKVVKIC 178 Query: 160 DFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAY 215 DFG ++ + S + ++APE L + Y K +DVWS G+ L+ + G Sbjct: 179 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVN 237 Query: 216 PFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 P+ NF K I + + + + E ++ + D KR S P + Sbjct: 238 PYPGIPVDANFYKLIQN----GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >3OMV-A nrPDB Length = 307 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 120/284 (42%), Gaps = 23/284 (8%) Query: 3 RPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV 62 RP ++ L IGSG+FG + VAVK ++ + E Sbjct: 20 RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQF 76 Query: 63 K---REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEAR 118 + E+ R RH NI+ F +T +LAIV ++ G L++ + +F + Sbjct: 77 QAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLI 135 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKS 175 +Q G+ Y HA + HRD+K N L +KI DFG + S Q + Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDMKSNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQ 193 Query: 176 TVGTPAYIAPEVLLKKEYD--GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 G+ ++APEV+ ++ + +DV+S G+ LY ++ G P+ N R I + Sbjct: 194 PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHI----NNRDQIIFM 249 Query: 234 LNVQYAIPD----YVHISPECRHLISRIFVADPAKRISIPEIRN 273 + YA PD Y + + L++ +R P+I + Sbjct: 250 VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILS 293 >3NIE-A nrPDB Length = 429 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 84/368 (22%), Positives = 130/368 (35%), Gaps = 90/368 (24%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID---ENVKREIINHRSLRHP 75 D YE+ IG G++G L DK +N+ VA+K + R + + + REI L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 76 NIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 I+R ++I+ L IV+E A +L + +E + L+ G + Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-------------------- 170 H + HRDLK N LL+ + +KICDFG +++ Sbjct: 147 IHESGIIHRDLKPANCLLNQDCS--VKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 171 ------SQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML-----------VG 213 Q S V T Y APE++L +E D+WS G +L Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 214 AYPFED----PEEPKNFRKTIHR---------ILNVQYAIPD------------------ 242 F P P + K +H I NV P+ Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 243 -----------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTM 291 Y IS E L+ + + KRI+I + +H + +L N +T Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTE 384 Query: 292 TTQFDESD 299 D Sbjct: 385 KIILPFDD 392 >3IO7-A nrPDB Length = 313 Score = 206 bits (526), Expect = 8e-54, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 120/281 (42%), Gaps = 26/281 (9%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDK----QSNELVAVKYIERG-EKIDENVKREIIN 68 + + ++ +G GNFG + R + E+VAVK ++ E+ + +REI Sbjct: 23 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI 82 Query: 69 HRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLI 125 +SL+H NIV++K V + +L ++MEY G L + + R + + Q+ Sbjct: 83 LKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 142 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTPA 181 G+ Y + HRDL N L++ R+KI DFG +K + Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIF 200 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG-----AYPFE------DPEEPKNFRKTI 230 + APE L + ++ +DVWS GV LY + + P E + ++ + + Sbjct: 201 WYAPESLTESKFSV-ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL 259 Query: 231 HRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L +P E +++ + + +R S ++ Sbjct: 260 IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5X02-A nrPDB Length = 347 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 109/296 (36%), Gaps = 42/296 (14%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRD---KQSNE--LVAVKYIERGEKIDEN--VK 63 DL + E K +GSG FG ++ VAVK ++ E + Sbjct: 40 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 99 Query: 64 REIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARF-- 119 E+ L H NIV + ++ EY G+L + +FSEDE + Sbjct: 100 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 159 Query: 120 --------------------FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC 159 F Q+ G+ + HRDL N L+ +KIC Sbjct: 160 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH--GKVVKIC 217 Query: 160 DFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAY 215 DFG ++ + S + ++APE L + Y K +DVWS G+ L+ + G Sbjct: 218 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVN 276 Query: 216 PFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 P+ NF K I + + + + E ++ + D KR S P + Sbjct: 277 PYPGIPVDANFYKLIQN----GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >4Y83-A nrPDB Length = 332 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 10/249 (4%) Query: 29 SGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPT 88 G FG L +D ++ + +A K I +D+ ++ RH NI +L Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIP----VDQFKPSDVEIQACFRHENIAELYGAVLWGE 138 Query: 89 HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL 148 + + ME GG + E++ + G E E + + ++ G+ + H+ +V H D+K N + Sbjct: 139 TVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF 198 Query: 149 DGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTL 207 + A + DFG S PK GT Y++PEV+L + + K AD++S G TL Sbjct: 199 MSTKAV---LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTK-ADIYSLGATL 254 Query: 208 YVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY-VHISPECRHLISRIFVADPAKRI 266 M G P+ + ++ I + D SP R LI +P R Sbjct: 255 IHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRP 314 Query: 267 SIPEIRNHE 275 ++ HE Sbjct: 315 RAADLLKHE 323 >4K33-A nrPDB Length = 325 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 117/296 (39%), Gaps = 38/296 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM------RDKQSN-ELVAVKYIERG--EKID 59 P D R L K +G G FG + +D+ + VAVK ++ +K Sbjct: 26 PADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL 85 Query: 60 ENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR------- 111 ++ E+ + + +H NI+ L +++EYA+ G L E + Sbjct: 86 SDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSF 145 Query: 112 ---------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 + + Q+ G+ Y + + HRDL N L+ +KI DFG Sbjct: 146 DTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV--MKIADFG 203 Query: 163 YSK---SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFE 218 ++ + + + + ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 204 LARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLLWEIFTLGGSPYP 262 Query: 219 DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 + F ++L + + + + + ++ + A P++R + ++ Sbjct: 263 GIPVEELF-----KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >6E4F-A nrPDB Length = 290 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 110/266 (41%), Gaps = 17/266 (6%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-VAVKYIERGEKIDENVKREIINHRSL 72 D +K++G+G FGV + K + VA+K I+ G ++ E +L Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 83 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISGVSYC 131 H +V+ V + I+ EY + G L + RF + + + + Y Sbjct: 84 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVL 188 + Q HRDL N L++ +K+ DFG S+ VL + S+VG+ + PEVL Sbjct: 144 ESKQFLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVL 200 Query: 189 LKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 + ++ K +D+W+ GV ++ + G P+E + + + + S Sbjct: 201 MYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHL-----AS 254 Query: 248 PECRHLISRIFVADPAKRISIPEIRN 273 + ++ + +R + + + Sbjct: 255 EKVYTIMYSCWHEKADERPTFKILLS 280 >1BYG-A nrPDB Length = 278 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 104/261 (39%), Gaps = 17/261 (6%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 + +L++ IG G FG L + VAVK I + + + E LRH N Sbjct: 19 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-KNDATAQAFLAEASVMTQLRHSN 75 Query: 77 IVRFKEVI-LTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHA 133 +V+ VI L IV EY + G L + + + GR D F + + Y Sbjct: 76 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 135 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 HRDL N L+ K+ DFG +K + + APE L +K++ Sbjct: 136 NNFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKKF 191 Query: 194 DGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 K +DVWS G+ L+ + G P+ P+ K + + Y + P Sbjct: 192 STK-SDVWSFGILLWEIYSFGRVPY-----PRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 245 Query: 253 LISRIFVADPAKRISIPEIRN 273 ++ + D A R S ++R Sbjct: 246 VMKNCWHLDAAMRPSFLQLRE 266 >5HI2-A nrPDB Length = 283 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 110/269 (40%), Gaps = 22/269 (8%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + + + IGSG+FG + VAVK + + + K E+ R R Sbjct: 15 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--TPQQLQAFKNEVGVLRKTR 69 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCH 132 H NI+ F T LAIV ++ G L+ + + +F + +Q G+ Y H Sbjct: 70 HVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLH 128 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVL- 188 A + HRDLK N L +KI DFG + S Q + G+ ++APEV+ Sbjct: 129 AKSIIHRDLKSNNIFLHEDNT--VKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR 186 Query: 189 -LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 +DV++ G+ LY ++ G P+ + N R I ++ PD + Sbjct: 187 MQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNI----NNRDQIIEMVGRGSLSPDLSKVR 242 Query: 248 PEC----RHLISRIFVADPAKRISIPEIR 272 C + L++ +R S P I Sbjct: 243 SNCPKRMKRLMAECLKKKRDERPSFPRIL 271 >3QA8-A nrPDB Length = 676 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/234 (29%), Positives = 104/234 (44%), Gaps = 13/234 (5%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER--GEKIDENVKREIINHRSLRHPNIV 78 +E+ + +G+G FG + + E VA+K + K E EI + L HPN+V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 79 RFKEV-----ILTPTHLAIV-MEYASGGELFERIC---NAGRFSEDEARFFFQQLISGVS 129 +EV L P L ++ MEY GG+L + + N E R + S + Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Y H ++ HRDLK EN +L P + KI D GY+K VGT Y+APE+L Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 +K+Y D WS G + + G PF +P + + N + D Sbjct: 196 EQKKYTV-TVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYD 248 >5X8I-B nrPDB Length = 346 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 119/322 (36%), Gaps = 68/322 (21%) Query: 20 RYELVKDIGSGNFGVARLMR-DKQSNELVAVKYIERGEKIDENVKREIINHRSLR--HPN 76 RYE+V +G G FG K VAVK ++ ++ E + EI L PN Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 77 ----IVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 V+ E H+ IV E G ++ I G F D R Q+ V++ Sbjct: 74 STFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNF 132 Query: 131 CHAMQVCHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHSQP 173 H+ ++ H DLK EN L S P +K+ DFG + H Sbjct: 133 LHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH--H 190 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF------- 226 + V T Y APEV+L + + DVWS G L +G F + ++ Sbjct: 191 STLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERIL 249 Query: 227 ----RKTIHRILNVQYAIPDYVH----------ISPECR-----------------HLIS 255 + I + +Y D + +S C+ LI Sbjct: 250 GPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQ 309 Query: 256 RIFVADPAKRISIPEIRNHEWF 277 ++ DPAKRI++ E H +F Sbjct: 310 KMLEYDPAKRITLREALKHPFF 331 >3ZBF-A nrPDB Length = 322 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 114/297 (38%), Gaps = 28/297 (9%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQ-----SNEL-VAVKYIERGEKIDE 60 G ++ ++ L +GSG FG S E+ VAVK +++G E Sbjct: 21 QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 80 Query: 61 N--VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFS----- 113 +E HPNI++ V L I++E GG+L + A + Sbjct: 81 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPL 140 Query: 114 --EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL---DGSPAPRLKICDFGYSK--- 165 + + G Y M HRDL N L+ D + +KI DFG ++ Sbjct: 141 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 200 Query: 166 SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPK 224 + + + + ++APE L+ + + +DVWS G+ ++ +L G P+ Sbjct: 201 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQ-SDVWSFGILIWEILTLGHQPYPAHSNLD 259 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNL 281 + + + + +L+++ + +P +R + I++ +N Sbjct: 260 VLNY-----VQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNF 311 >5HIE-A nrPDB Length = 302 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 111/269 (41%), Gaps = 22/269 (8%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + + + IGSG+FG + VAVK + + + K E+ R R Sbjct: 31 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--TPQQLQAFKNEVGVLRKTR 85 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICN-AGRFSEDEARFFFQQLISGVSYCH 132 H NI+ F T LAIV ++ G L+ + +F + +Q G+ Y H Sbjct: 86 HVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLH 144 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVL- 188 A + HRDLK N L +KI DFG + S Q + G+ ++APEV+ Sbjct: 145 AKSIIHRDLKSNNIFLHEDLT--VKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR 202 Query: 189 -LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 K +DV++ G+ LY ++ G P+ + N R I ++ Y PD + Sbjct: 203 MQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI----NNRDQIIFMVGRGYLSPDLSKVR 258 Query: 248 PEC----RHLISRIFVADPAKRISIPEIR 272 C + L++ +R P+I Sbjct: 259 SNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >5FM2-A nrPDB Length = 355 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 111/296 (37%), Gaps = 43/296 (14%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDE--NVK 63 D L K +G G FG + + VAVK ++ E ++ Sbjct: 56 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 115 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR------------ 111 E + + HP++++ L +++EYA G L + + + Sbjct: 116 SEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 175 Query: 112 ------------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKIC 159 + + F Q+ G+ Y M++ HRDL N L+ ++KI Sbjct: 176 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE--GRKMKIS 233 Query: 160 DFGYSKS-SVLHSQPKSTVG--TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAY 215 DFG S+ S K + G ++A E L Y + +DVWS GV L+ ++ G Sbjct: 234 DFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGN 292 Query: 216 PFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 P+ + F +L + + + S E L+ + + +P KR +I Sbjct: 293 PYPGIPPERLFN-----LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >3BEA-A nrPDB Length = 333 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 57/289 (19%), Positives = 102/289 (35%), Gaps = 33/289 (11%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-----VAVKYIERGEKIDEN-- 61 P + + + K +G+G FG + VAVK ++ DE Sbjct: 36 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 95 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--------- 111 + E+ L +H NIV + ++ EY G+L + R Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFA 155 Query: 112 -----FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS 166 S + F Q+ G+++ + HRD+ N LL KI DFG ++ Sbjct: 156 IANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLARD 213 Query: 167 SVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEE 222 + S + ++APE + Y + +DVWS G+ L+ + G P+ Sbjct: 214 IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGILV 272 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 F K ++ Y + ++ + +P R + +I Sbjct: 273 NSKFYK----LVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >1S9I-A nrPDB Length = 354 Score = 203 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 128/307 (41%), Gaps = 49/307 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSLRHPN 76 D +E + ++G+GN GV ++ + S ++A K I E I + RE+ P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 75 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC-HAMQ 135 IV F + ++I ME+ GG L + + A R E+ ++ G++Y Q Sbjct: 76 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ 135 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + HRD+K N L++ +K+CDFG S + S S VGT +Y+APE L + Sbjct: 136 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMAPERLQG-THYS 191 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKN------------------------------ 225 +D+WS G++L + VG YP P+ + Sbjct: 192 VQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 251 Query: 226 ------------FRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + + I+N +P+ + +++ + +PA+R + + N Sbjct: 252 SGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTN 311 Query: 274 HEWFLKN 280 H + ++ Sbjct: 312 HTFIKRS 318 >4H1J-A nrPDB Length = 293 Score = 203 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 103/256 (40%), Gaps = 18/256 (7%) Query: 25 KDIGSGNFGVARLMR---DKQSNELVAVKYIERG--EKIDENVKREIINHRSLRHPNIVR 79 + +G G FG K VAVK ++ E E + ++L HP+IV+ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 89 Query: 80 FKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 +I I+ME GEL + N + Q+ ++Y ++ H Sbjct: 90 LIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 148 Query: 139 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLKKEYDGK 196 RD+ + N L+ +K+ DFG S+ K++V +++PE + + + Sbjct: 149 RDIAVRNILVASPEC--VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTT- 205 Query: 197 VADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 +DVW V ++ +L G PF E K + +L +P P L++ Sbjct: 206 ASDVWMFAVCMWEILSFGKQPFFWLEN-----KDVIGVLEKGDRLPKPDLCPPVLYTLMT 260 Query: 256 RIFVADPAKRISIPEI 271 R + DP+ R E+ Sbjct: 261 RCWDYDPSDRPRFTEL 276 >3BBT-B nrPDB Length = 328 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 21/272 (7%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELV----AVKYIER--GEKIDENVKR 64 L I+ +++ + VK +GSG FG E V A+K + G K + Sbjct: 8 QLRILKETE-LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMD 66 Query: 65 EIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQ 123 E + S+ HP++VR V L+PT + +V + G L E + + Q Sbjct: 67 EALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ 125 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---TP 180 + G+ Y ++ HRDL N L+ +KI DFG ++ + + G Sbjct: 126 IAKGMMYLEERRLVHRDLAARNVLVKS--PNHVKITDFGLARLLEGDEKEYNADGGKMPI 183 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++A E + +++ + +DVWS GVT++ M G P++ + I +L Sbjct: 184 KWMALECIHYRKFTHQ-SDVWSYGVTIWELMTFGGKPYDGIPT-----REIPDLLEKGER 237 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +P + + ++ + ++ D R E+ Sbjct: 238 LPQPPICTIDVYMVMVKCWMIDADSRPKFKEL 269 >4HVI-A nrPDB Length = 314 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 103/281 (36%), Gaps = 25/281 (8%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMR----DKQSNELVAVKYI-ERGEKIDENVKREII 67 P + + + + +G GNFG L R + LVAVK + G + +REI Sbjct: 4 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 63 Query: 68 NHRSLRHPNIVRFKEVILTPTH--LAIVMEYASGGELFERICNAG-RFSEDEARFFFQQL 124 ++L IV+++ V P L +VMEY G L + + R + Q+ Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 123 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTP 180 G+ Y + + HRDL N L++ +KI DFG +K L Sbjct: 124 CKGMEYLGSRRCVHRDLAARNILVESE--AHVKIADFGLAKLLPLDKDYYVVREPGQSPI 181 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR-------- 232 + APE L + + +DVWS GV LY + P R Sbjct: 182 FWYAPESLSDNIF-SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRL 240 Query: 233 --ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +L +P E L+ + P R S + Sbjct: 241 LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >2OGV-A nrPDB Length = 317 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 100/285 (35%), Gaps = 29/285 (10%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-----VAVKYIERGEKIDEN-- 61 P + + + K +G+G FG + VAVK ++ DE Sbjct: 28 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 87 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA----------G 110 + E+ L +H NIV + ++ EY G+L + Sbjct: 88 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 170 + F Q+ G+++ + HRD+ N LL KI DFG ++ + Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLARDIMND 205 Query: 171 SQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNF 226 S + ++APE + Y + +DVWS G+ L+ + G P+ F Sbjct: 206 SNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGILVNSKF 264 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 K ++ Y + ++ + +P R + +I Sbjct: 265 YK----LVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >1LUF-A nrPDB Length = 343 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 109/289 (37%), Gaps = 45/289 (15%) Query: 16 HDSDRYELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIER--GEKIDENVKREIIN 68 + + E V+DIG G FG R + +VAVK ++ + + +RE Sbjct: 44 YPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 103 Query: 69 HRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG------------------ 110 +PNIV+ V + ++ EY + G+L E + + Sbjct: 104 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARV 163 Query: 111 ------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS 164 S E +Q+ +G++Y + HRDL N L+ + +KI DFG S Sbjct: 164 SSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV--VKIADFGLS 221 Query: 165 K---SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDP 220 + S+ + + ++ PE + Y + +DVW+ GV L+ + G P+ Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTE-SDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 221 -EEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISI 268 E + IL + E +L+ + PA R S Sbjct: 281 AHEEVIYYVRDGNILACP------ENCPLELYNLMRLCWSKLPADRPSF 323 >4IDT-A nrPDB Length = 356 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 109/256 (42%), Gaps = 23/256 (8%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G+FG M DKQ+ AVK + ++ E++ L P IV + Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVR----LEVFRAEELMACAGLTSPRIVPLYGAVR 136 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 + I ME GG L + + G ED A ++ Q + G+ Y H+ ++ H D+K +N Sbjct: 137 EGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADN 196 Query: 146 TLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLKKEYDGKVAD 199 LL +CDFG++ K + GT ++APEV+L + D K D Sbjct: 197 VLLSSDG-SHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAK-VD 254 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL----IS 255 VWS + ML G +P+ + FR + L + P I P C L I Sbjct: 255 VWSSCCMMLHMLNGCHPWT-----QFFRGPL--CLKIASEPPPVREIPPSCAPLTAQAIQ 307 Query: 256 RIFVADPAKRISIPEI 271 +P R+S E+ Sbjct: 308 EGLRKEPIHRVSAAEL 323 >5TQX-A nrPDB Length = 655 Score = 201 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 78/351 (22%), Positives = 137/351 (39%), Gaps = 48/351 (13%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVK--YIERGEKIDENVKREIINHRSLRHPNIV 78 +E+ + +G+G FG L + ++ + +A+K +E K E EI + L H N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 79 RFKEVILTPTHLAIV--------MEYASGGELFERICNAGR---FSEDEARFFFQQLISG 127 + P L I+ MEY SGG+L + + E + + SG Sbjct: 70 K---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 126 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 + Y H ++ HRDLK EN +L + KI D GY+K VGT Y+APE Sbjct: 127 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE 186 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI----------LNV 236 + K Y D WS G ++ + G PF +P + + I + ++ Sbjct: 187 LFENKPYTA-TVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSG 245 Query: 237 QYAIPDYVHISPECRHLI--------SRIFVADPAKR-----ISIPE-----IRNHEWFL 278 + ++ LI + DP +R +++ + + +H L Sbjct: 246 EVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNL 305 Query: 279 KNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYL 329 K + M + + D+ S++ +I E + + L+ Sbjct: 306 KIVHILNMTSAKIISFLLPPDESLHSLQS--RIERETGINTGSQELLSETG 354 >3G0E-A nrPDB Length = 336 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 104/295 (35%), Gaps = 37/295 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDEN-- 61 P D +R K +G+G FG + VAVK ++ + E Sbjct: 36 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA 95 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG---------- 110 + E+ L H NIV ++ EY G+L + Sbjct: 96 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 111 --------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 ++ F Q+ G+++ + HRDL N LL KICDFG Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT--KICDFG 213 Query: 163 YSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFE 218 ++ S + ++APE + Y + +DVWS G+ L+ + G+ P+ Sbjct: 214 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFE-SDVWSYGIFLWELFSLGSSPYP 272 Query: 219 DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 F K ++ + + H E ++ + ADP KR + +I Sbjct: 273 GMPVDSKFYK----MIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >3KRL-A nrPDB Length = 335 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 101/291 (34%), Gaps = 35/291 (12%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-----VAVKYIERGEKIDEN-- 61 P + + + K +G+G FG + VAVK ++ DE Sbjct: 36 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 95 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--------- 111 + E+ L +H NIV + ++ EY G+L + Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNP 155 Query: 112 -------FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS 164 S + F Q+ G+++ + HRD+ N LL KI DFG + Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLA 213 Query: 165 KSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDP 220 + + S + ++APE + Y + +DVWS G+ L+ + G P+ Sbjct: 214 RDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGI 272 Query: 221 EEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 F K ++ Y + ++ + +P R + +I Sbjct: 273 LVNSKFYK----LVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >5U6B-A nrPDB Length = 307 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 113/308 (36%), Gaps = 39/308 (12%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSN--ELVAVKYIE---RGEKIDENVKREIIN 68 +M D + L K +G G FG + Q + VAVK ++ E+ E + Sbjct: 18 VMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVC 77 Query: 69 HRSLRHPNIVRFKEVILTPTHL------AIVMEYASGGELFERIC------NAGRFSEDE 116 + HPN++R V + +++ + G+L + Sbjct: 78 MKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQM 137 Query: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQP 173 F + SG+ Y + HRDL N +L+ + + + + DFG SK + Q Sbjct: 138 LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS--VCVADFGLSKKIYNGDYYRQG 195 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHR 232 + +IA E L + Y K +DVWS GVT++ + G P+ E + + Sbjct: 196 RIAKMPVKWIAIESLADRVYTSK-SDVWSFGVTMWEIATRGQTPYPGVENSEIYDY---- 250 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMT 292 L + L+SR + +P R S E+R DL N Sbjct: 251 -LRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE----------DLENTLKAL 299 Query: 293 TQFDESDQ 300 E D+ Sbjct: 300 PPAQEPDE 307 >4F0G-A nrPDB Length = 287 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 74/277 (26%), Positives = 120/277 (43%), Gaps = 22/277 (7%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE--------NVK 63 LP + D++ E K IG G FG+ R + +VA+K + G+ E + Sbjct: 13 LPTLADNE-IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQ 71 Query: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQ 122 RE+ +L HPNIV+ ++ P +VME+ G+L+ R+ A Sbjct: 72 REVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLML 129 Query: 123 QLISGVSYCHAMQ--VCHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 + G+ Y + HRDL+ N LD + K+ DFG S+ SV + Sbjct: 130 DIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--SVSGLL 187 Query: 178 GTPAYIAPEVL-LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 G ++APE + ++E + AD +S + LY +L G PF++ K + R + Sbjct: 188 GNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGL 247 Query: 237 QYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + IP+ P R++I + DP KR I Sbjct: 248 RPTIPE--DCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >3QUP-A nrPDB Length = 323 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 103/281 (36%), Gaps = 30/281 (10%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSN---ELVAVKYIERG---EKIDENVKREII 67 ++ ++ L + +G G FG R + KQ + VAVK ++ E RE Sbjct: 18 VLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAA 77 Query: 68 NHRSLRHPNIVRFKEVILT---PTHLAI---VMEYASGGELFERIC------NAGRFSED 115 + HP++ + V L L I ++ + G+L + N Sbjct: 78 CMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQ 137 Query: 116 EARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 175 F + G+ Y + HRDL N +L + + DFG S+ + Sbjct: 138 TLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMT--VCVADFGLSRKIYSGDYYRQ 195 Query: 176 TVGTP---AYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIH 231 + ++A E L Y +DVW+ GVT++ M G P+ E + + I Sbjct: 196 GCASKLPVKWLALESLADNLYTV-HSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI- 253 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIR 272 + E L+ + + ADP +R S +R Sbjct: 254 ----GGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLR 290 >4R7H-A nrPDB Length = 343 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 101/298 (33%), Gaps = 42/298 (14%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNEL-----VAVKYIERGEKIDEN-- 61 P + + + K +G+G FG + VAVK ++ DE Sbjct: 40 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 99 Query: 62 VKREIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA----------- 109 + E+ L +H NIV + ++ EY + G+L + Sbjct: 100 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSP 159 Query: 110 ------------GRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 + F Q+ G+++ + HRD+ N LL K Sbjct: 160 GQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--K 217 Query: 158 ICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-G 213 I DFG ++ + S + ++APE + Y + +DVWS G+ L+ + G Sbjct: 218 IGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQ-SDVWSYGILLWEIFSLG 276 Query: 214 AYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 P+ F K ++ Y + ++ + +P R + +I Sbjct: 277 LNPYPGILVNSKFYK----LVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >4XLV-A nrPDB Length = 328 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 111/291 (38%), Gaps = 35/291 (12%) Query: 14 IMHDSDRYELVKDIGSGNFGVARL--MRDKQSNE---LVAVKYIERGEKIDEN--VKREI 66 ++ L++++G G+FG+ RD E VAVK + + E E Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 93 Query: 67 INHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICN----------AGRFSEDE 116 + ++VR V+ +VME + G+L + + + E Sbjct: 94 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 153 Query: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQP 173 ++ G++Y +A + HRDL N ++ +KI DFG ++ + + + Sbjct: 154 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT--VKIGDFGMTRDIYETDYYRKG 211 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHR 232 + ++APE L + +D+WS GV L+ + P++ + + Sbjct: 212 GKGLLPVRWMAPESLKDGVFTT-SSDMWSFGVVLWEITSLAEQPYQGLSN----EQVLKF 266 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN------HEWF 277 +++ Y + + L+ + +P R + EI N H F Sbjct: 267 VMDGGY-LDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >5B2L-A nrPDB Length = 324 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 121/272 (44%), Gaps = 18/272 (6%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKIDENVKREI-INHRSLRHP 75 + E + ++GSG G MR +++ ++AVK + R ++ ++ + ++ + +S P Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVSYC-H 132 IV+ +T T + I ME G E++ G E ++ + Y Sbjct: 77 YIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL--- 189 V HRD+K N LLD ++K+CDFG S V + G AY+APE + Sbjct: 135 KHGVIHRDVKPSNILLDE--RGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 190 -KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA-IPDYVHIS 247 K ADVWS G++L + G +P+++ K + + ++L + +P ++ S Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNC---KTDFEVLTKVLQEEPPLLPGHMGFS 249 Query: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 + + + D KR ++ H + + Sbjct: 250 GDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 281 >4C59-A nrPDB Length = 340 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 70/281 (24%), Positives = 119/281 (42%), Gaps = 39/281 (13%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYI-ERGEKIDENVKREIINHRSLR-HPNI 77 R + + + G F +D S A+K + E+ + + +E+ + L HPNI Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNI 87 Query: 78 VRF--------KEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISG 127 V+F +E ++ E G E +++ + G S D F Q Sbjct: 88 VQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 147 Query: 128 VSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK----------- 174 V + H + + HRDLK+EN LL +K+CDFG + + + Sbjct: 148 VQHMHRQKPPIIHRDLKVENLLLSNQGT--IKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 175 --STVGTPAYIAPEVL-LKKEYD-GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 + TP Y PE++ L + G+ D+W+ G LY++ +PFED + Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL------- 258 Query: 231 HRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 RI+N +Y+IP + LI + +P +R+SI E+ Sbjct: 259 -RIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >4TPT-A nrPDB Length = 303 Score = 198 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 119/272 (43%), Gaps = 32/272 (11%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVK-YIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 + +G G FG A + K + +++ +K I E+ + E+ RSL HPN+++F Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 V+ L ++ EY GG L + + + F + F + + SG++Y H+M + HRDL Sbjct: 65 VLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLN 124 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHS---------------------QPKSTVGTPA 181 N L+ + + DFG S+ V + + VG P Sbjct: 125 SHNCLIKLDKT--VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 ++APE+L K YD + D++S G+ L ++ + +P +T+ LNV+ Sbjct: 183 WMAPEMLNGKSYD-ETVDIFSFGIVLCEII-----GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 242 DYV--HISPECRHLISRIFVADPAKRISIPEI 271 +V P L + +P R + ++ Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >3CJF-A nrPDB Length = 309 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 110/287 (38%), Gaps = 32/287 (11%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIERGEKIDEN--VKRE 65 DR L K +G G FG + VAVK ++ G E+ + E Sbjct: 21 KWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSE 80 Query: 66 IINHRSL-RHPNIVRFKEVILTPT-HLAIVMEYASGGELFERICNAGR------------ 111 + + H N+V P L +++E+ G L + + Sbjct: 81 LKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDF 140 Query: 112 FSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSV 168 + + + Q+ G+ + + + HRDL N LL +KICDFG ++ Sbjct: 141 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNV--VKICDFGLARDIYKDP 198 Query: 169 LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFR 227 + + ++APE + + Y + +DVWS GV L+ + GA P+ + + F Sbjct: 199 DYVRKGDARLPLKWMAPETIFDRVYTIQ-SDVWSFGVLLWEIFSLGASPYPGVKIDEEF- 256 Query: 228 KTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 R L + + +PE + + +P++R + E+ H Sbjct: 257 ---CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >5GRN-A nrPDB Length = 356 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 108/302 (35%), Gaps = 49/302 (16%) Query: 9 PMDLP----IMHDSDRYELVKDIGSGNFGVARL--MRDKQSNE---LVAVKYIERGEKID 59 PM LP D L + +GSG FG ++ VAVK ++ + Sbjct: 32 PMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS 91 Query: 60 EN--VKREIINHRSLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG------ 110 E + E+ L H NIV + I+ EY G+L + Sbjct: 92 EKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSH 151 Query: 111 --------------------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDG 150 + + F Q+ G+ + + HRDL N LL Sbjct: 152 KKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-- 209 Query: 151 SPAPRLKICDFGYSKSSVLHSQPKSTVGT---PAYIAPEVLLKKEYDGKVADVWSCGVTL 207 + +KICDFG ++ + S S T ++APE + Y ++DVWS G+ L Sbjct: 210 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTT-LSDVWSYGILL 268 Query: 208 YVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 + + G P+ F I Y + H + E ++ + + ++P KR Sbjct: 269 WEIFSLGGTPYPGMMVDSTFYNKI----KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRP 324 Query: 267 SI 268 S Sbjct: 325 SF 326 >3PLS-A nrPDB Length = 298 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 66/258 (25%), Positives = 111/258 (43%), Gaps = 21/258 (8%) Query: 25 KDIGSGNFGVAR--LMRDKQSNEL-VAVKYIERGEKID--ENVKREIINHRSLRHPNIVR 79 + IG G+FGV D+ N + A+K + R ++ E RE + R L HPN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 80 FKEVILTPTHL-AIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQVC 137 ++L P L +++ Y G+L + I + R + + F Q+ G+ Y + Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFV 146 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 HRDL N +LD S +K+ DFG + + Q + + A E L Sbjct: 147 HRDLAARNCMLDESFT--VKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 193 YDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 + K +DVWS GV L+ +L GA P+ + + L +P + Sbjct: 205 FTTK-SDVWSFGVLLWELLTRGAPPYRHIDPFD-----LTHFLAQGRRLPQPEYCPDSLY 258 Query: 252 HLISRIFVADPAKRISIP 269 ++ + + ADPA R + Sbjct: 259 QVMQQCWEADPAVRPTFR 276 >2WO6-A nrPDB Length = 382 Score = 197 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 114/330 (34%), Gaps = 72/330 (21%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHP-- 75 DRYE+ IG G+FG D+ E VA+K I+ + + E+ + +H Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 76 ---NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 IV K + HL +V E S L++ + N S + R F QQ+ + + + Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 131 CH--AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 + + H DLK EN LL +KI DFG S L + + + Y +PEVL Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSS--CQLGQRIYQYIQSRFYRSPEVL 230 Query: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT------------------- 229 L YD D+WS G L M G F E K Sbjct: 231 LGMPYDL-AIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR 289 Query: 230 ------------------------------IHRILNVQYAIPDYVHISP---------EC 250 +H IL V+ P + Sbjct: 290 KFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKF 349 Query: 251 RHLISRIFVADPAKRISIPEIRNHEWFLKN 280 + LI R+ DP RI H +F K Sbjct: 350 KDLILRMLDYDPKTRIQPYYALQHSFFKKT 379 >3LZB-A nrPDB Length = 327 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 108/263 (41%), Gaps = 20/263 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELV----AVKYIER--GEKIDENVKREIINHRSLR 73 ++ +K +GSG FG E V A+K + K ++ + E S+ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 75 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCH 132 +P++ R + LT T + ++ + G L + + + Q+ G++Y Sbjct: 76 NPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 134 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---TPAYIAPEVLL 189 ++ HRDL N L+ +KI DFG +K + G ++A E +L Sbjct: 135 DRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + Y + +DVWS GVT++ M G+ P++ + I IL +P + Sbjct: 193 HRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-----ISSILEKGERLPQPPICTI 246 Query: 249 ECRHLISRIFVADPAKRISIPEI 271 + ++ + ++ D R E+ Sbjct: 247 DVYMIMRKCWMIDADSRPKFREL 269 >3PP0-A nrPDB Length = 338 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 115/271 (42%), Gaps = 21/271 (7%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELV----AVKYIER--GEKIDENVKRE 65 L I+ +++ VK +GSG FG E V A+K + K ++ + E Sbjct: 11 LRILKETE-LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDE 69 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQL 124 + P + R + LT T + +V + G L + + N GR + + Q+ Sbjct: 70 AYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQI 128 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---TPA 181 G+SY +++ HRDL N L+ +KI DFG ++ + G Sbjct: 129 AKGMSYLEDVRLVHRDLAARNVLVKS--PNHVKITDFGLARLLDIDETEYHADGGKVPIK 186 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 ++A E +L++ + + +DVWS GVT++ M GA P++ + I +L + Sbjct: 187 WMALESILRRRFTHQ-SDVWSYGVTVWELMTFGAKPYDGIPA-----REIPDLLEKGERL 240 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEI 271 P + + ++ + ++ D R E+ Sbjct: 241 PQPPICTIDVYMIMVKCWMIDSECRPRFREL 271 >3C1X-A nrPDB Length = 373 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 112/280 (40%), Gaps = 28/280 (10%) Query: 5 AVSGPMDLPIMHDSDRYELVKDIGSGNFGVAR---LMRDKQSNELVAVKYIERGEKIDE- 60 V GP L + + + IG G+FG L+ + AVK + R I E Sbjct: 82 VVIGPSSLIVHFN-------EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEV 134 Query: 61 -NVKREIINHRSLRHPNIVRFKEVIL-TPTHLAIVMEYASGGELFERICNAGR-FSEDEA 117 E I + HPN++ + L + +V+ Y G+L I N + + Sbjct: 135 SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL 194 Query: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 177 F Q+ G+ + + + HRDL N +LD +K+ DFG ++ Sbjct: 195 IGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFT--VKVADFGLARDMYDKEFDSVHN 252 Query: 178 GT-----PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIH 231 T ++A E L +++ K +DVWS GV L+ ++ GA P+ D F T++ Sbjct: 253 KTGAKLPVKWMALESLQTQKFTTK-SDVWSFGVLLWELMTRGAPPYPDVN---TFDITVY 308 Query: 232 RILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + + P+Y ++ + + R S E+ Sbjct: 309 LLQGRRLLQPEY--CPDPLYEVMLKCWHPKAEMRPSFSEL 346 >6FYV-A nrPDB Length = 337 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 112/322 (34%), Gaps = 68/322 (21%) Query: 20 RYELVKDIGSGNFGVARLMRDKQ-SNELVAVKYIERGEKIDENVKREIINHRSLRH--PN 76 RYE+V +G G FG D VAVK ++ + E + EI L PN Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 77 ----IVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 V+ E H+ IV E G ++ I F D R Q+ +++ Sbjct: 75 SVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQSINF 133 Query: 131 CHAMQVCHRDLKLENTLLDGS-----------------PAPRLKICDFGYSKSSVLHSQP 173 H ++ H DLK EN L S +K+ DFG + H Sbjct: 134 LHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH--H 191 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE----------- 222 + V T Y APEV+L + + DVWS G L +G F+ + Sbjct: 192 STLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 250 Query: 223 ---PKNFRKTIHRILNVQYAIPDYVHIS------------------------PECRHLIS 255 P++ + + + D+ S + L+ Sbjct: 251 GPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVR 310 Query: 256 RIFVADPAKRISIPEIRNHEWF 277 R+ DP +RI++ E H +F Sbjct: 311 RMLEYDPTQRITLDEALQHPFF 332 >5HLW-A nrPDB Length = 299 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 106/260 (40%), Gaps = 21/260 (8%) Query: 25 KDIGSGNFGVAR---LMRDKQSNELVAVKYIERGEKIDE--NVKREIINHRSLRHPNIVR 79 + IG G+FG L+ + AVK + R I E E I + HPN++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 80 FKEVIL-TPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAMQVC 137 + L + +V+ Y G+L I N + + F Q+ G+ Y + + Sbjct: 86 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV 145 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT-----PAYIAPEVLLKKE 192 HRDL N +LD +K+ DFG ++ T ++A E L ++ Sbjct: 146 HRDLAARNCMLDEKFT--VKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 193 YDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 + K +DVWS GV L+ ++ GA P+ D F T++ + + P+Y Sbjct: 204 FTTK-SDVWSFGVLLWELMTRGAPPYPDVN---TFDITVYLLQGRRLLQPEY--CPDPLY 257 Query: 252 HLISRIFVADPAKRISIPEI 271 ++ + + R S E+ Sbjct: 258 EVMLKCWHPKAEMRPSFSEL 277 >4G3E-A nrPDB Length = 352 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 68/254 (26%), Positives = 107/254 (42%), Gaps = 15/254 (5%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 +G G+FG M+DKQ+ AVK + ++ E++ L P IV + Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVR----LEVFRVEELVACAGLSSPRIVPLYGAVR 136 Query: 86 TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLEN 145 + I ME GG L + I G ED A ++ Q + G+ Y H ++ H D+K +N Sbjct: 137 EGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADN 196 Query: 146 TLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLKKEYDGKVAD 199 LL R +CDFG++ KS + GT ++APEV++ K D K D Sbjct: 197 VLLSSDG-SRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAK-VD 254 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFV 259 +WS + ML G +P+ K ++ P ++ + I Sbjct: 255 IWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQA---IQEGLR 311 Query: 260 ADPAKRISIPEIRN 273 +P R S E+R Sbjct: 312 KEPVHRASAMELRR 325 >5GNK-A nrPDB Length = 297 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 109/263 (41%), Gaps = 20/263 (7%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELV----AVKYIER--GEKIDENVKREIINHRSLR 73 ++ +K +GSG FG E V A+K + K ++ + E S+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCH 132 +P++ R + LT T + ++M+ G L + + + Q+ G++Y Sbjct: 80 NPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 138 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---TPAYIAPEVLL 189 ++ HRDL N L+ +KI DFG +K + G ++A E +L Sbjct: 139 DRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISP 248 + Y + +DVWS GVT++ M G+ P++ + I IL +P + Sbjct: 197 HRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-----ISSILEKGERLPQPPICTI 250 Query: 249 ECRHLISRIFVADPAKRISIPEI 271 + ++ + ++ D R E+ Sbjct: 251 DVYMIMVKCWMIDADSRPKFREL 273 >5TE0-A nrPDB Length = 347 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 130/338 (38%), Gaps = 39/338 (11%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV-KREIINHRSLR-HPNIVR 79 + + + G F + L+R + A+K + + D V KREI R L H NIV Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVG 80 Query: 80 FKEVILTPT------HLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVSYC 131 + + + + I+M++ GG++ + F+E+E F V+ Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARL 140 Query: 132 HAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTP 180 H + + HRDLK+EN LL +CDFG + + + Q + T Sbjct: 141 HQCKTPIIHRDLKVENILL--HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 181 AYIAPEV--LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 +Y APE+ L + AD+W+ G LY + PF + + I + + Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA---------ICDGNF 249 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEW--FLKNLPADLMNDNTMTTQFD 296 IPD S + LI + DP KR I ++ + K P + ++ + + Sbjct: 250 TIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLP 309 Query: 297 ESDQPGQ--SIEEIMQIIAEATVPPAGTQNLNHYLTGS 332 E + + + + + +P T L Sbjct: 310 EPVKASEAAAKKTQPKARLTDPIPTTETSIAAENLYFQ 347 >1U59-A nrPDB Length = 287 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 103/253 (40%), Gaps = 19/253 (7%) Query: 26 DIGSGNFGVAR--LMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHPNIVRFK 81 ++G GNFG R + R ++ VA+K +++G + E + RE L +P IVR Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 82 EVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRD 140 V L +VME A GG L + + Q+ G+ Y HRD Sbjct: 77 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 135 Query: 141 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLKKEYDGK 196 L N LL KI DFG SK+ + + APE + +++ + Sbjct: 136 LAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 197 VADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 +DVWS GVT++ + G P++ + P + + I + + PE L+S Sbjct: 194 -SDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK-RMECPPECPPELYALMS 247 Query: 256 RIFVADPAKRISI 268 ++ R Sbjct: 248 DCWIYKWEDRPDF 260 >6HMD-A nrPDB Length = 365 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 124/302 (41%), Gaps = 41/302 (13%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 +P + D Y+LV+ +G G + + +NE V + +KRE+ Sbjct: 45 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV--VKILKPVKKKKIKREVKILE 102 Query: 71 SLRHP-NIVRFKEVILTP--THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 +LR NI++ + + P A+V EY + + + ++ + RF+ +L+ Sbjct: 103 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKA 159 Query: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 + YCH+ + HRD+K N ++D +L++ D+G ++ + V + + PE+ Sbjct: 160 LDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 218 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFE----------------DPEEPKNFRKTIH 231 L+ + D+WS G L M+ PF EE + K H Sbjct: 219 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 278 Query: 232 RILNVQY----------AIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHE 275 L+ + +++H +SPE L+ ++ D +R++ E H Sbjct: 279 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 338 Query: 276 WF 277 +F Sbjct: 339 YF 340 >5WNO-A nrPDB Length = 330 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 103/258 (39%), Gaps = 18/258 (6%) Query: 22 ELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 +L K +G+G FG R K VA+K + + + + E N LRH N Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDN 84 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISGVSYCHAMQ 135 +++ + L IV Y G L + + E + Q+ SG+ Y + Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKE 192 V HRDL N L+ ++I DFG SK + KS ++A E+ K Sbjct: 145 VVHRDLATRNVLV--KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC 202 Query: 193 YDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Y +DVW+ GVT + ++ G P++ +IH L + + S + Sbjct: 203 YTH-ASDVWAFGVTCWEIITFGQSPYQGMST-----DSIHNFLKDGNRLSQPPNCSQDLY 256 Query: 252 HLISRIFVADPAKRISIP 269 + R ++ADP R Sbjct: 257 QELLRCWMADPKSRPGFE 274 >5UIU-A nrPDB Length = 323 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 68/268 (25%), Positives = 108/268 (40%), Gaps = 26/268 (9%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIE-----RGEKIDENVKREIINHRSLRHPNIVRF 80 +G G FGV +N VAVK + E++ + +EI +H N+V Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 81 KEVILTPTHLAIVMEYASGGELFERIC---NAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 L +V Y G L +R+ S Q +G+++ H Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLKKEYD 194 HRD+K N LLD + KI DFG +++S +Q VGT AY+APE L + Sbjct: 172 HRDIKSANILLDEAFTA--KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--I 227 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH--------I 246 +D++S GV L ++ G ++ EP+ I + + I DY+ Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 287 Query: 247 SPEC-RHLISRIFVADPAKRISIPEIRN 273 S E + S+ KR I +++ Sbjct: 288 SVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >2OZO-A nrPDB Length = 613 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 110/286 (38%), Gaps = 27/286 (9%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVK--------DIGSGNFGVAR--LMRDKQSNELVAVK 50 MD P P + L + ++G GNFG R + R ++ VA+K Sbjct: 310 MDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIK 369 Query: 51 YIERGEK--IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC- 107 +++G + E + RE L +P IVR V L +VME A GG L + + Sbjct: 370 VLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG 428 Query: 108 NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 Q+ G+ Y HR+L N LL KI DFG SK+ Sbjct: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYA--KISDFGLSKAL 486 Query: 168 VLHSQPKSTVG----TPAYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEE 222 + + APE + +++ + +DVWS GVT++ + G P++ + Sbjct: 487 GADDSYYTARSAGKWPLKWYAPECINFRKFSSR-SDVWSYGVTMWEALSYGQKPYKKMKG 545 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISI 268 P + + I + + PE L+S ++ R Sbjct: 546 P----EVMAFIEQGK-RMECPPECPPELYALMSDCWIYKWEDRPDF 586 >3RAW-A nrPDB Length = 381 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 118/332 (35%), Gaps = 68/332 (20%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNE-LVAVKYIERGEKIDENVKREIINHRSLRHPN 76 +RYE+V ++G G FG D + VA+K I K E + EI + ++ + Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD 109 Query: 77 ------IVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGV 128 V + H+ I E G FE + N + R QL + Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 168 Query: 129 SYCHAMQVCHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHS 171 + H Q+ H DLK EN L S +++ DFG + + H Sbjct: 169 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--TFDHE 226 Query: 172 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRK--- 228 + V T Y PEV+L+ + + DVWS G L+ G F+ E ++ Sbjct: 227 HHTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEK 285 Query: 229 --------TIHRILNVQYAIP----------DYVHISPECR-----------------HL 253 IHR +Y D ++ C+ L Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 254 ISRIFVADPAKRISIPEIRNHEWFLKNLPADL 285 + R+ DPA+RI++ E H +F P + Sbjct: 346 MRRMLEFDPAQRITLAEALLHPFFAGLTPEER 377 >4OW8-A nrPDB Length = 283 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 72/259 (27%), Positives = 100/259 (38%), Gaps = 19/259 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 69 Query: 74 HPNIVRFKEVIL-----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + +VME +G L + GR S A +Q + Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 129 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ +Q +GT YIAPE Sbjct: 130 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L + +DV+S GV Y + G PF K I + Sbjct: 188 QALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP-----PDL 241 Query: 247 SPECRHLISRIFVADPAKR 265 P R LI V +PA R Sbjct: 242 PPNVRELIEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 72/259 (27%), Positives = 100/259 (38%), Gaps = 19/259 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 70 Query: 74 HPNIVRFKEVIL-----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + +VME +G L + GR S A +Q + Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 130 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ +Q +GT YIAPE Sbjct: 131 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L + +DV+S GV Y + G PF K I + Sbjct: 189 QALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP-----PDL 242 Query: 247 SPECRHLISRIFVADPAKR 265 P R LI V +PA R Sbjct: 243 PPNVRELIEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 72/259 (27%), Positives = 100/259 (38%), Gaps = 19/259 (7%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLR 73 S RY L + I +G G D + VAVK ++ D E + E L Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 90 Query: 74 HPNIVRFKEVIL-----TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 HP I + +VME +G L + GR S A +Q + Sbjct: 91 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 150 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPAYIAPE 186 HA + HRD+K N L+ +P ++KI DFG +K+ +Q +GT YIAPE Sbjct: 151 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 L + +DV+S GV Y + G PF K I + Sbjct: 209 QALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP-----PDL 262 Query: 247 SPECRHLISRIFVADPAKR 265 P R LI V +PA R Sbjct: 263 PPNVRELIEITLVKNPAMR 281 >2A1A-B nrPDB Length = 284 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/273 (23%), Positives = 110/273 (40%), Gaps = 36/273 (13%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 ++ ++ IGSG FG + + + +K ++ +E +RE+ L H NIV Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN---NEKAEREVKALAKLDHVNIVH 68 Query: 80 FKEVILTPTH----------------LAIVMEYASGGELFERICNAG--RFSEDEARFFF 121 + + L I ME+ G L + I + + A F Sbjct: 69 YNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELF 128 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 +Q+ GV Y H+ ++ +RDLK N L ++KI DFG S + + GT Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFL--VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 182 YIAPEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 Y++PE + ++Y GK D+++ G+ L +L V FE + + R I Sbjct: 187 YMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGII--------- 236 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + + L+ ++ P R + EI Sbjct: 237 --SDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >4MD7-E nrPDB Length = 391 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 120/298 (40%), Gaps = 41/298 (13%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 + D Y+LV+ +G G + + +NE V + +KREI +LR Sbjct: 33 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV--VKILKPVKKKKIKREIKILENLRG 90 Query: 75 -PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 PNI+ +++ P A+V E+ + + + ++ + RF+ +++ + YC Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 147 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H+M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ-------------- 237 + D+WS G L M+ PF + + I ++L + Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 238 ------------YAIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +VH +SPE + ++ D R++ E H +F Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >4LRM-A nrPDB Length = 334 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 117/285 (41%), Gaps = 26/285 (9%) Query: 3 RPAVSGPMD--LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELV----AVKYIER-- 54 P+ P L I+ +++ ++ +K +GSG FG E V A+K + Sbjct: 2 SPSGEAPNQALLRILKETE-FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT 60 Query: 55 GEKIDENVKREIINHRSLRHP---NIVRFKEVILTPTHLAIVMEYASGGELFERICNAG- 110 K ++ + E S+ +P ++ R + LT T + ++ + G L + + Sbjct: 61 SPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKD 119 Query: 111 RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 170 + Q+ G++Y ++ HRDL N L+ +KI DFG +K Sbjct: 120 NIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAE 177 Query: 171 SQPKSTVG---TPAYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNF 226 + G ++A E +L + Y + +DVWS GVT++ M G+ P++ + Sbjct: 178 EKEYHAEGGKVPIKWMALESILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-- 234 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 I IL +P + + ++ + ++ D R E+ Sbjct: 235 ---ISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFREL 276 >3AOX-A nrPDB Length = 344 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 52/276 (18%), Positives = 100/276 (36%), Gaps = 25/276 (9%) Query: 17 DSDRYELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIER--GEKIDENVKREIINH 69 L++ +G G FG + + S VAVK + E+ + + E + Sbjct: 45 PRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALII 104 Query: 70 RSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-------FSEDEARFFFQ 122 H NIVR V L I++E +GG+L + + + + Sbjct: 105 SKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 164 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRL-KICDFGYSK---SSVLHSQPKSTVG 178 + G Y HRD+ N LL R+ KI DFG ++ + + + + Sbjct: 165 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAML 224 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQ 237 ++ PE ++ + K D WS GV L+ + G P+ ++ + + + Sbjct: 225 PVKWMPPEAFMEGIFTSK-TDTWSFGVLLWEIFSLGYMPYPSKSN----QEVLEFVTSGG 279 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + + ++++ + P R + I Sbjct: 280 -RMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >5UNP-A nrPDB Length = 369 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 128/339 (37%), Gaps = 70/339 (20%) Query: 18 SDRYELVKDIGSGNFGVARLMR-DKQSNELVAVKYIERGEKIDENVKREIINHRSLR--- 73 +RYE+V +G G FG ++ VA+K I+ EK E + EI + Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKD 92 Query: 74 --HPNI-VRFKEVILTPTHLAIVMEYASGGELFERICNAGRFS--EDEARFFFQQLISGV 128 + N+ V+ + H+ I E G F+ + + + R QL V Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAV 151 Query: 129 SYCHAMQVCHRDLKLENTLLDGS-----------------PAPRLKICDFGYSKSSVLHS 171 + H ++ H DLK EN L S + +++ DFG + + H Sbjct: 152 KFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA--TFDHE 209 Query: 172 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF----- 226 + V T Y APEV+L+ + + DVWS G ++ VG F+ + ++ Sbjct: 210 HHSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMER 268 Query: 227 ------RKTIHRILNVQYAIP---DYVH-------ISPECR-----------------HL 253 + I + +Y D+ + C+ L Sbjct: 269 ILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDL 328 Query: 254 ISRIFVADPAKRISIPEIRNHEWF--LKNLPADLMNDNT 290 I + +PAKR+++ E H +F L+ P + + D++ Sbjct: 329 IESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSS 367 >5XVU-A nrPDB Length = 332 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 122/301 (40%), Gaps = 41/301 (13%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + +RYE++K IG G + D + N A + +KREI ++L Sbjct: 26 QWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA--IKVLKPVKKKKIKREIKILQNLN 83 Query: 74 H-PNIVRFKEVILTP--THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 PNI++ +++ P +++ EY + + +F++ + R++ Q++ + Y Sbjct: 84 GGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALDY 140 Query: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 CH+ + HRD+K N ++D ++++ +G ++ + V + Y PE+L+ Sbjct: 141 CHSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLID 199 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN--------------- 235 + D+WS G L M+ PF + + I ++L Sbjct: 200 LQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKL 259 Query: 236 --------VQYAIPDYVHI---------SPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 +Y + H E LI ++ + D AKRI+ E H +F Sbjct: 260 KPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFR 319 Query: 279 K 279 + Sbjct: 320 E 320 >4CRL-A nrPDB Length = 406 Score = 188 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 123/315 (39%), Gaps = 62/315 (19%) Query: 26 DIGSGNFGVARLMRDKQSNEL--VAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEV 83 +G G +G + K + A+K IE G I + REI R L+HPN++ ++V Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE-GTGISMSACREIALLRELKHPNVISLQKV 87 Query: 84 ILT--PTHLAIVMEYASGGELFERIC---------NAGRFSEDEARFFFQQLISGVSYCH 132 L+ + ++ +YA +L+ I + + Q++ G+ Y H Sbjct: 88 FLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLH 146 Query: 133 AMQVCHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKS----TVGTPAYIAPE 186 A V HRDLK N L+ +G R+KI D G+++ +P + V T Y APE Sbjct: 147 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAY-------------PFEDPEEPKNF------- 226 +LL + K D+W+ G +L P+ + + F Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 266 Query: 227 --------RKTIHRILNVQYAIPDYVHIS-------------PECRHLISRIFVADPAKR 265 + H L + Y + S + HL+ ++ DP KR Sbjct: 267 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 326 Query: 266 ISIPEIRNHEWFLKN 280 I+ + +FL++ Sbjct: 327 ITSEQAMQDPYFLED 341 >2BUJ-A nrPDB Length = 317 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 71/281 (25%), Positives = 117/281 (41%), Gaps = 26/281 (9%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-ENVKREIINHRSL 72 ++ D+ Y ++ +G G F L+ A+K I E+ D E +RE HR Sbjct: 24 VIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLF 83 Query: 73 RHPNIVRFKEVILTPT----HLAIVMEYASGGELF---ERICNAGRF-SEDEARFFFQQL 124 HPNI+R L +++ + G L+ ER+ + G F +ED+ + + Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGI 143 Query: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------- 177 G+ HA HRDLK N LL P L D G + +H + Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLM--DLGSMNQACIHVEGSRQALTLQDWA 201 Query: 178 ---GTPAYIAPEVLLKKEY--DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR 232 T +Y APE+ + + + DVWS G LY M+ G P++ + + ++ Sbjct: 202 AQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD---SVAL 258 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + Q +IP S L++ + DP +R IP + + Sbjct: 259 AVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLS 299 >2WTK-B nrPDB Length = 373 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 126/339 (37%), Gaps = 66/339 (19%) Query: 21 YELVKDIGSGNF---GVARLMRDKQSNELVAVKYIERGEKIDENV---KREIINHRSLRH 74 YEL+ IG G F L R K + E V V+ I +E V + E+ + H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVSYCH 132 PNIV ++ + L +V + + G + IC +E + Q ++ + Y H Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 133 AMQVCHRDLKLENTLLDGSP-------APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 185 M HR +K + L+ L + G + V+H PK +V +++P Sbjct: 130 HMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG-QRQRVVHDFPKYSVKVLPWLSP 188 Query: 186 EVLLK--KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHR----------I 233 EVL + + YD K +D++S G+T + G PF+D + + ++ I Sbjct: 189 EVLQQNLQGYDAK-SDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTI 247 Query: 234 LNVQYAI------------------------------PDYVHISPECRHLISRIFVADPA 263 + + P + SP H + + +P Sbjct: 248 PAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPD 307 Query: 264 KRISIPEIRNHEWFLKNLP------ADLMNDNTMTTQFD 296 R S + NH +F + +L+ T T F+ Sbjct: 308 ARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFE 346 >5VD3-A nrPDB Length = 311 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 105/265 (39%), Gaps = 19/265 (7%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSL-RHPN 76 ++ + +G G++G +R K+ L AVK RG K E+ +H + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVSYCHAMQ 135 VR ++ L + E G L + G E + + + + +++ H+ Sbjct: 119 CVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQG 177 Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 + H D+K N L P R K+ DFG + G P Y+APE+L G Sbjct: 178 LVHLDVKPANIFLG--PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YG 233 Query: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY-VHISPECRHLI 254 ADV+S G+T+ + E + R+ Y P++ +S E R ++ Sbjct: 234 TAADVFSLGLTILEVACNMELPHGGEGWQQLRQ--------GYLPPEFTAGLSSELRSVL 285 Query: 255 SRIFVADPAKRISIPEIRNHEWFLK 279 + DP R + + + Sbjct: 286 VMMLEPDPKLRATAEALLALPVLRQ 310 >4NEU-A nrPDB Length = 333 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 113/295 (38%), Gaps = 27/295 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE---KIDENVKREIINHRS 71 M SD E + + SG FG L + ++ +K + +G + +E + E Sbjct: 21 MKSSDFLESAE-LDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNR 78 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 LRH +V+ VI+ ++VMEY G L + ++I G+ Y Sbjct: 79 LRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYL 138 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYS--------------KSSVLHSQPKSTV 177 H V H+DLK EN L+D +KI D G + + + K Sbjct: 139 HGKGVIHKDLKPENILVDND--FHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 178 GTPAYIAPEVLLK-KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNV 236 GT Y+APE L + +DV+S V L+ + P+E+ + I Sbjct: 197 GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKS--GN 254 Query: 237 QYAIPDYVH-ISPECRHLISRIFVADPAKRISIPEIRNH--EWFLKNLPADLMND 288 + + D E L+ + A+P R + P I ++L L + D Sbjct: 255 RPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED 309 >6EII-A nrPDB Length = 352 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 120/298 (40%), Gaps = 41/298 (13%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 + D Y+LV+ +G G + + +NE V + +KREI +LR Sbjct: 56 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV--VKILKPVKKKKIKREIKILENLRG 113 Query: 75 -PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 PNI+ +++ P A+V E+ + + + ++ + RF+ +++ + YC Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 170 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H+M + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ-------------- 237 + D+WS G L M+ PF + + I ++L + Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 238 ------------YAIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 +VH +SPE + ++ D R++ E H +F Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >5IKW-A nrPDB Length = 310 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 119/304 (39%), Gaps = 42/304 (13%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENV-KREIINHRSLR-HPNIVR 79 L + + G F L+R A+K + D NV KREI + L H NIV Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVG 75 Query: 80 FKEVILTPT-----HLAIVMEYASGGELFERICNA--GRFSEDEARFFFQQLISGVSYCH 132 + + + + I+MEY G++ ++ F+E E F V+ H Sbjct: 76 YLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLH 135 Query: 133 AMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTPA 181 + + HRDLK+EN LL + +CDFG + + L+ Q T + Sbjct: 136 QCKTPIIHRDLKVENILL--NDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 182 YIAPEVLL--KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 Y APE++ + AD+W+ G LY + PF + + I + + Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA---------ICDGNFT 244 Query: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF-----LKNLPADLMNDNTMTTQ 294 IPD S LI + DP R +I +F + P +N++++ + Sbjct: 245 IPDNSRYSRNIHCLIRFMLEPDPEHRP---DIFQVSYFAFKFAAADCPVSNINNSSIPSA 301 Query: 295 FDES 298 E Sbjct: 302 LPEP 305 >3UIU-A nrPDB Length = 306 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 110/286 (38%), Gaps = 49/286 (17%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 ++ ++ IGSG FG + + + ++ ++ +E +RE+ L H NIV Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYN---NEKAEREVKALAKLDHVNIVH 69 Query: 80 FKEVILTPTH-----------------------------LAIVMEYASGGELFERICNAG 110 + + L I ME+ G L + I Sbjct: 70 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 129 Query: 111 --RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 168 + + A F+Q+ GV Y H+ ++ HRDLK N L ++KI DFG S Sbjct: 130 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL--VDTKQVKIGDFGLVTSLK 187 Query: 169 LHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFR 227 + + GT Y++PE + ++Y GK D+++ G+ L +L V FE + + R Sbjct: 188 NDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLR 246 Query: 228 KTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 I + + L+ ++ P R + EI Sbjct: 247 DGII-----------SDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >6CTH-A nrPDB Length = 309 Score = 186 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 110/305 (36%), Gaps = 36/305 (11%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR-EIINHRSLRHPN 76 + + +G G FG + S+ +AVK + R K E+ LRH N Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKN 73 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF-FFQQLISGVSYCHAMQ 135 +V+ L +V E+ + G L I E R+ + L S + Y H Sbjct: 74 LVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEG 133 Query: 136 ---VCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLK 190 V HRD+K N +LD S K+ DFG ++ + GT Y+APE L Sbjct: 134 DHCVLHRDIKTSNIMLDSSFNA--KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSS 191 Query: 191 KEYDGKVADVWSCGVTLYVMLVGAY---------------PF-EDPEEPKNFRKTIHRIL 234 + K +DV+S GV + G P+ + + R L Sbjct: 192 GK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKL 250 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAK--RISIPEIRNHEWFLKNLPADLMNDNTMT 292 + + + ++ ++ A P+ R SI ++ F P + + Sbjct: 251 GMAFDPKQLECL------VMVGLWCAHPSHNLRPSIRQVIQVLNF--EAPLPNLPGSMPI 302 Query: 293 TQFDE 297 +++ Sbjct: 303 PNYND 307 >4M7I-A nrPDB Length = 299 Score = 186 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 110/289 (38%), Gaps = 42/289 (14%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHPNI 77 +E ++ +G G FGV ++K + A+K I E E V RE+ L HP I Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 65 Query: 78 VRFKEVILTPT------------HLAIVMEYASGGELFERICNAGRFSEDEA---RFFFQ 122 VR+ L +L I M+ L + + E E F Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---------- 172 Q+ V + H+ + HRDLK N +K+ DFG + + Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 173 ---PKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT 229 VGT Y++PE + Y K D++S G+ L+ +L YPF E +T Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSYSHK-VDIFSLGLILFELL---YPFSTQMERV---RT 236 Query: 230 IHRILNVQYAIPDYVHISPECRHLISR-IFVADPAKRISIPEIRNHEWF 277 + + N+++ P C +++ + + P +R I + F Sbjct: 237 LTDVRNLKF--PPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF 283 >3I81-A nrPDB Length = 315 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 104/274 (37%), Gaps = 29/274 (10%) Query: 19 DRYELVKDIGSGNFGVARLMRDK-----QSNELVAVKYIERGEKIDEN--VKREIINHRS 71 ++ + +++G G+FG+ K + VA+K + + E E + Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKE 77 Query: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG----------RFSEDEARFFF 121 ++VR V+ ++ME + G+L + + S + Sbjct: 78 FNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMA 137 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVG 178 ++ G++Y +A + HRDL N ++ +KI DFG ++ + + + + Sbjct: 138 GEIADGMAYLNANKFVHRDLAARNCMVAEDFT--VKIGDFGMTRDIYETDYYRKGGKGLL 195 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQ 237 +++PE L + +DVWS GV L+ + P++ + R + L Sbjct: 196 PVRWMSPESLKDGVFTTY-SDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGL--- 251 Query: 238 YAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + + L+ + +P R S EI Sbjct: 252 --LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >4YFF-A nrPDB Length = 311 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 67/260 (25%), Positives = 104/260 (40%), Gaps = 18/260 (6%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRSLRHPNI 77 E + IGSG+FG R + N++VA+K ++ RE+ L HP + Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 78 VRFKEVIL-TPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ-QLISGVSYCHA-- 133 ++F L P+ AIV +Y SGG LF + R + +++ + G+ Y H Sbjct: 103 IQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLT 162 Query: 134 MQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKK 191 + HRDL N LL + DFG S+ S+ G ++APEV + Sbjct: 163 QPIIHRDLNSHNILLYEDGHAVV--ADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC 220 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 ADV+S + L+ +L G PF + + P I Sbjct: 221 TRYTIKADVFSYALCLWEILTGEIPFAHLKPAA----AAADMAYHHIRPPIGYSIPKPIS 276 Query: 252 HLISRIFVADPAKRISIPEI 271 L+ R + A P R E+ Sbjct: 277 SLLIRGWNACPEGRPEFSEV 296 >2PVN-A nrPDB Length = 352 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 53/300 (17%), Positives = 120/300 (40%), Gaps = 39/300 (13%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 + D YE+V+ +G G + + +NE + I + K + + I Sbjct: 47 QWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCII-KILKPVKKKKIKREIKILQNLCG 105 Query: 74 HPNIVRFKEVILT--PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 PNIV+ +++ +++ EY + + F+ + ++ + R++ +L+ + YC Sbjct: 106 GPNIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVL--YPTLTDYDIRYYIYELLKALDYC 162 Query: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 H+ + HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 163 HSQGIMHRDVKPHNVMIDHELR-KLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN---------------- 235 + D+WS G M+ PF + + I ++L Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 236 -------VQYAIPDYVH---------ISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +++ ++ +SPE + ++ D +R++ E H +F + Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 >4JLC-A nrPDB Length = 657 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 56/233 (24%), Positives = 100/233 (42%), Gaps = 16/233 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRF 80 L +G G R K++ +L AVK + + RE + L H NIV+ Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 81 KEVIL--TPTHLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 136 VCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK--- 190 + HRD+K N + + K+ DFG ++ Q S GT Y+ P++ + Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 191 ----KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++ G D+WS GVT Y G+ PF E P+ ++ +++I+ + + Sbjct: 192 RKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >5U6C-A nrPDB Length = 315 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 108/291 (37%), Gaps = 30/291 (10%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQ---SNELVAVKYIE---RGEKIDENVKREII 67 ++ D + L K +G G FG KQ ++ VAVK ++ ++ E E Sbjct: 31 VVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAA 90 Query: 68 NHRSLRHPNIVRFKEVILTP-----THLAIVMEYASGGELFERI------CNAGRFSEDE 116 + HPN++R V + +++ + G+L + Sbjct: 91 CMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQT 150 Query: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQP 173 F + G+ Y HRDL N +L + + DFG SK + Q Sbjct: 151 LLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMT--VCVADFGLSKKIYSGDYYRQG 208 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHR 232 + +IA E L + Y K +DVW+ GVT++ + G P+ + + + +H Sbjct: 209 RIAKMPVKWIAIESLADRVYTSK-SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLH- 266 Query: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI-RNHEWFLKNLP 282 + + E ++ + DP R + + E L++LP Sbjct: 267 ----GHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP 313 >4EUU-A nrPDB Length = 319 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 100/233 (42%), Gaps = 16/233 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRF 80 L +G G R K++ +L A+K + + RE + L H NIV+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 81 KEVIL--TPTHLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 136 VCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK--- 190 + HR++K N + + K+ DFG ++ Q S GT Y+ P++ + Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 191 ----KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++ G D+WS GVT Y G+ PF E P+ ++ +++I+ + + Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5TOS-A nrPDB Length = 395 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 58/289 (20%), Positives = 101/289 (34%), Gaps = 42/289 (14%) Query: 18 SDRYELVKDIGSGNFGVARLM---------RDKQSNELVAVKYIE-RGEKIDENVKREII 67 + + IG G FG + ++AVK + G + EI Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG----RFSEDEARFFFQQ 123 L HPN+V+ L H +V E+ G L + G Sbjct: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 Query: 124 LISGVSYCHA--MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVG 178 G+++ H+ ++V +RD+K N LLD K+ DFG ++ + +G Sbjct: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK-------------- 224 T Y APE + + + +DV+S GV L +L G + K Sbjct: 242 TYGYAAPEYMSSGHLNAR-SDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 Query: 225 --NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + L+ QY + V ++ + +P R ++ ++ Sbjct: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLSFEPKSRPTMDQV 345 >4EUT-A nrPDB Length = 396 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 100/233 (42%), Gaps = 16/233 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRF 80 L +G G R K++ +L A+K + + RE + L H NIV+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 81 KEVIL--TPTHLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 136 VCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK--- 190 + HR++K N + + K+ DFG ++ Q S GT Y+ P++ + Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 191 ----KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++ G D+WS GVT Y G+ PF E P+ ++ +++I+ + + Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >4FL3-A nrPDB Length = 635 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 92/255 (36%), Gaps = 19/255 (7%) Query: 25 KDIGSGNFGVARLMR-----DKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 K++GSGNFG + ++ + +K + + + E + L +P IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 + + + +VME A G L + + + Q+ G+ Y HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLKKEYDG 195 DL N LL KI DFG SK+ + APE + ++ Sbjct: 494 DLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 Query: 196 KVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K +DVWS GV ++ G P+ + + + +L + E L+ Sbjct: 552 K-SDVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAGCPREMYDLM 605 Query: 255 SRIFVADPAKRISIP 269 + + D R Sbjct: 606 NLCWTYDVENRPGFA 620 >3MDY-A nrPDB Length = 337 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 117/294 (39%), Gaps = 43/294 (14%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 + + ++VK IG G +G + K E VAVK E+ + EI +RH NI Sbjct: 36 AKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENI 93 Query: 78 VRFKEVILTP----THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 + F + T L ++ +Y G L++ + + +SG+ + H Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-LDAKSMLKLAYSSVSGLCHLHT 152 Query: 134 M--------QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTP 180 + HRDLK +N L+ + I D G + + + P + VGT Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 181 AYIAPEV----LLKKEYDGKV-ADVWSCGVTLYVMLVG----------AYPFEDPEEPKN 225 Y+ PEV L + + + AD++S G+ L+ + P+ D Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 270 Query: 226 FRKTIHRILNVQYAIPDYVH--ISPECR----HLISRIFVADPAKRISIPEIRN 273 + + I+ ++ P + + S EC L++ + +PA R++ ++ Sbjct: 271 SYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 324 >5VC6-A nrPDB Length = 289 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 119/296 (40%), Gaps = 37/296 (12%) Query: 8 GPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKR 64 G + + ++ +EL + IGSG FG + + A+K ++ G ++N R Sbjct: 1 GAGSMKSRYTTEFHEL-EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALR 59 Query: 65 EIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----FSEDEARF 119 E+ H L +H ++VR+ H+ I EY +GG L + I R F E E + Sbjct: 60 EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRL-----------------KICDFG 162 Q+ G+ Y H+M + H D+K N + + P KI D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 163 YSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEE 222 + S P+ G ++A EVL + AD+++ +T+ V GA P P Sbjct: 180 HVTRI---SSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPL--PRN 233 Query: 223 PKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + + L IP +S E L+ + DP +R S + H L Sbjct: 234 GDQWHEIRQGRL---PRIPQV--LSQEFTELLKVMIHPDPERRPSAMALVKHSVLL 284 >3Q4U-A nrPDB Length = 301 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 113/294 (38%), Gaps = 43/294 (14%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 + L++ +G G +G R E VAVK ++ + E+ N LRH NI Sbjct: 7 ARDITLLECVGKGRYGEV--WRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENI 64 Query: 78 VRFKEVILTPTH----LAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH- 132 + F +T H L ++ Y G L++ + + SG+++ H Sbjct: 65 LGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL-QLTTLDTVSCLRIVLSIASGLAHLHI 123 Query: 133 -------AMQVCHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTP 180 + HRDLK +N L+ + + I D G + ++ L VGT Sbjct: 124 EIFGTQGKPAIAHRDLKSKNILVKKN--GQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 181 AYIAPEVLLK----KEYDG-KVADVWSCGVTLYVMLVG----------AYPFEDPEEPKN 225 Y+APEVL + +D K D+W+ G+ L+ + PF D Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 241 Query: 226 FRKTIHRIL---NVQYAIPDYVHISP---ECRHLISRIFVADPAKRISIPEIRN 273 + + +++ + IP+ P L+ + +P+ R++ I+ Sbjct: 242 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >3MY0-A nrPDB Length = 305 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 105/289 (36%), Gaps = 43/289 (14%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 LV+ +G G +G R E VAVK ++ + EI N LRH NI+ F Sbjct: 12 LVECVGKGRYGEV--WRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 83 VILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH------ 132 +T T L ++ Y G L++ + A G+++ H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFL-QRQTLEPHLALRLAVSAACGLAHLHVEIFGT 128 Query: 133 --AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-----KSTVGTPAYIAP 185 + HRD K N L+ + + I D G + S VGT Y+AP Sbjct: 129 QGKPAIAHRDFKSRNVLVKSNL--QCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAP 186 Query: 186 EVLLKKEYDG-----KVADVWSCGVTLYVMLVG----------AYPFED---PEEPKNFR 227 EVL ++ K D+W+ G+ L+ + PF D + Sbjct: 187 EVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM 246 Query: 228 KTIHRILNVQYAIPDYVHISPECRHL---ISRIFVADPAKRISIPEIRN 273 K + + IP+ + P L + + +P+ R++ I+ Sbjct: 247 KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >6J5U-C nrPDB Length = 426 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 101/286 (35%), Gaps = 36/286 (12%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQS---------NELVAVKYIE-RGEKIDENVKREII 67 + + +G G FG Q+ +VAVK ++ G + + E+ Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVN 142 Query: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLI 125 L HPN+V + +V E+ G L + G + Sbjct: 143 YLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAA 202 Query: 126 SGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTP 180 G+++ H + V +RD K N LLD K+ DFG +K+ +GT Sbjct: 203 KGLTFLHEAKSQVIYRDFKAANILLDADFNA--KLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF------------RK 228 Y APE + K +DV+S GV L ++ G ++ + ++ Sbjct: 261 GYAAPEYVATGRLTAK-SDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKR 319 Query: 229 TIHRILNVQYA--IPDYVHISPECRHLISRIFVADPAKRISIPEIR 272 + RI++ + P + +L + D R + E+ Sbjct: 320 KLFRIMDTKLGGQYPQKGAFT--AANLALQCLNPDAKLRPKMSEVL 363 >6O8B-A nrPDB Length = 665 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 99/233 (42%), Gaps = 16/233 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRF 80 L +G G R K++ +L A+K + + RE + L H NIV+ Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 81 KEVIL--TPTHLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 136 VCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK--- 190 + HR++K N + + K+ DFG ++ Q GT Y+ P++ + Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 191 ----KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++ G D+WS GVT Y G+ PF E P+ ++ +++I+ + + Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >6NT9-A nrPDB Length = 742 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 100/233 (42%), Gaps = 16/233 (6%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNIVRF 80 L +G G R K++ +L A+K + + RE + L H NIV+ Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 81 KEVIL--TPTHLAIVMEYASGGELFERI---CNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 + T H ++ME+ G L+ + NA E E + ++ G+++ Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 136 VCHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK--- 190 + HR++K N + + K+ DFG ++ Q S GT Y+ P++ + Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 191 ----KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 ++ G D+WS GVT Y G+ PF E P+ ++ +++I+ + + Sbjct: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >5C26-A nrPDB Length = 299 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 92/255 (36%), Gaps = 19/255 (7%) Query: 25 KDIGSGNFGVARLMR-----DKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVR 79 K++GSGNFG + ++ + +K + + + E + L +P IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 + + + +VME A G L + + + Q+ G+ Y HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 140 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLKKEYDG 195 DL N LL KI DFG SK+ + APE + ++ Sbjct: 152 DLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 209 Query: 196 KVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 K +DVWS GV ++ G P+ + + + +L + E L+ Sbjct: 210 K-SDVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAGCPREMYDLM 263 Query: 255 SRIFVADPAKRISIP 269 + + D R Sbjct: 264 NLCWTYDVENRPGFA 278 >5LPZ-A nrPDB Length = 332 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 103/280 (36%), Gaps = 26/280 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKY-IERGEKIDENVKREIINHRSLR 73 + ++ + IGSG FG K VA+K I + D E+ ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIK 71 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG----RFSEDEARFFFQQLISGVS 129 H N+V +V E+ G L + + + + + R G++ Sbjct: 72 HRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 130 YCHAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYI 183 + H + HRD+K N LLD + R+ DFG ++ + H + GTP Y+ Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEARV--SDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN----FRKTIHRILNVQYA 239 PE K DV+S GV L +L G P + P+ N + K ++ Sbjct: 190 PPEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVF 248 Query: 240 IPDYVHISPEC-RHLISR------IFVADPAKRISIPEIR 272 P+ + P L+ +R ++ ++ Sbjct: 249 DPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5LPV-A nrPDB Length = 296 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 103/280 (36%), Gaps = 26/280 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKY-IERGEKIDENVKREIINHRSLR 73 + ++ + IGSG FG K VA+K I + D E+ ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIK 71 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG----RFSEDEARFFFQQLISGVS 129 H N+V +V E+ G L + + + + + R G++ Sbjct: 72 HRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 130 YCHAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYI 183 + H + HRD+K N LLD + R+ DFG ++ + H + GTP Y+ Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEARV--SDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN----FRKTIHRILNVQYA 239 PE K DV+S GV L +L G P + P+ N + K ++ Sbjct: 190 PPEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVF 248 Query: 240 IPDYVHISPEC-RHLISR------IFVADPAKRISIPEIR 272 P+ + P L+ +R ++ ++ Sbjct: 249 DPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >3ZZW-A nrPDB Length = 289 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 50/277 (18%), Positives = 103/277 (37%), Gaps = 35/277 (12%) Query: 22 ELVKDIGSGNFGVARLMR-----DKQSNELVAVKYIERGEK--IDENVKREIINHRSLRH 74 ++++G FG + + VA+K ++ + + E + E + L+H Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR----------------FSEDEAR 118 PN+V V+ L+++ Y S G+L E + + Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 119 FFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQPKS 175 Q+ +G+ Y + V H+DL N L+ +KI D G + + + + Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKL--NVKISDLGLFREVYAADYYKLLGN 189 Query: 176 TVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPEEPKNFRKTIHRIL 234 ++ ++APE ++ ++ +D+WS GV L+ G P+ +R + Sbjct: 190 SLLPIRWMAPEAIMYGKFSI-DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 +P L+ + P++R +I Sbjct: 249 -----LPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5CEK-A nrPDB Length = 263 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 19/248 (7%) Query: 35 ARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIV 93 + + K D+ I + L H NI EVIL T + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDK-----IRPYIQLPSHSNITGIVEVILGETKAYVF 79 Query: 94 MEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPA 153 E G++ + + R E+EA F+Q++S V++CH + DLKL + Sbjct: 80 FE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER 138 Query: 154 PRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVLL-KKEYDGKVADVWSCGVTLYV 209 +L++ + ++ + + G PAY++PE+L Y GK ADVWS GV LY Sbjct: 139 TQLRLES--LEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 196 Query: 210 MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIP 269 +LVG YPF D + F K I Q+ IP+ HISP+ R LI + +P++R++ P Sbjct: 197 LLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAP 250 Query: 270 EIRNHEWF 277 EI H WF Sbjct: 251 EILLHPWF 258 >6DC0-A nrPDB Length = 292 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 19/248 (7%) Query: 35 ARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHPNIVRFKEVILTPTHLAIV 93 + + K D+ I + L H NI EVIL T + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDK-----IRPYIQLPSHSNITGIVEVILGETKAYVF 76 Query: 94 MEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPA 153 E G++ + + R E+EA F+Q++S V++CH + DLKL + Sbjct: 77 FE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER 135 Query: 154 PRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVLL-KKEYDGKVADVWSCGVTLYV 209 +L++ + ++ + + G PAY++PE+L Y GK ADVWS GV LY Sbjct: 136 TQLRLES--LEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 193 Query: 210 MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIP 269 +LVG YPF D + F K I Q+ IP+ HISP+ R LI + +P++R++ P Sbjct: 194 LLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAP 247 Query: 270 EIRNHEWF 277 EI H WF Sbjct: 248 EILLHPWF 255 >4IAN-A nrPDB Length = 358 Score = 176 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 117/326 (35%), Gaps = 68/326 (20%) Query: 20 RYELVKDIGSGNFGVARLMRDKQS-NELVAVKYIERGEKIDENVKREIINHRSLRHP--- 75 RY + G G F RD N+ VAVK I E + + +E+ + L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 76 ---NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR---FSEDEARFFFQQLISGVS 129 + +R HL +V E S L E + G+ R + QQL + Sbjct: 91 DKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALK 149 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 + H D+K +N L++ S LK+CDFG + S V + + + Y APE+++ Sbjct: 150 LLKRCNILHADIKPDNILVNESKTI-LKLCDFGSA-SHVADNDITPYLVSRFYRAPEIII 207 Query: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFR-------------------KTI 230 K YD D+WS G TLY + G F + K Sbjct: 208 GKSYD-YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQ 266 Query: 231 HRILNVQYAIPDYVHISP-----------------------------------ECRHLIS 255 H N+ + + ++ + + L+ Sbjct: 267 HFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLD 326 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNL 281 +I + DPAKRISI + H + + + Sbjct: 327 QILMLDPAKRISINQALQHAFIQEKI 352 >2RIO-A nrPDB Length = 434 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 121/310 (39%), Gaps = 37/310 (11%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEV 83 K +G G+ G + + VAVK + + EI HPN++R+ Sbjct: 21 KILGYGSSGTV-VFQGSFQGRPVAVKRMLIDFC--DIALMEIKLLTESDDHPNVIRYYCS 77 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEAR-------FFFQQLISGVSYCHAMQV 136 T L I +E + L + + + E+ +Q+ SGV++ H++++ Sbjct: 78 ETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKI 136 Query: 137 CHRDLKLENTLLDGS-----------PAPRLKICDFGYSKSSVLH-----SQPKSTVGTP 180 HRDLK +N L+ S R+ I DFG K + + GT Sbjct: 137 IHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTS 196 Query: 181 AYIAPEV------LLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRI 233 + APE+ L K + D++S G Y +L G +PF D ++ Sbjct: 197 GWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFS 256 Query: 234 LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL-KNLPADLMNDNTMT 292 L+ + D I E LIS++ DP KR + ++ H F K+ + + + Sbjct: 257 LDEMKCLHDRSLI-AEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDR 315 Query: 293 TQFDESDQPG 302 + + D P Sbjct: 316 LEIENRDPPS 325 >1PY5-A nrPDB Length = 326 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 108/289 (37%), Gaps = 43/289 (14%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 L + IG G FG R K E VAVK E+ + EI LRH NI+ F Sbjct: 33 LQESIGKGRFGEV--WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 83 VILTPT----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH------ 132 L +V +Y G LF+ + E + SG+++ H Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALSTASGLAHLHMEIVGT 149 Query: 133 --AMQVCHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTPAYIAP 185 + HRDLK +N L+ + I D G + + + P VGT Y+AP Sbjct: 150 QGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 186 EVL-----LKKEYDGKVADVWSCGVTLYVMLVG----------AYPFEDPEEPKNFRKTI 230 EVL +K K AD+++ G+ + + P+ D + + Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEM 267 Query: 231 HRILNVQYAIPDYVHISPECRHL------ISRIFVADPAKRISIPEIRN 273 +++ Q P+ + C L + + A+ A R++ I+ Sbjct: 268 RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >6HV0-A nrPDB Length = 416 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 72/270 (26%), Positives = 111/270 (41%), Gaps = 31/270 (11%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVI 84 +G G G + R N VAVK I + RE+ R HPN++R+ Sbjct: 15 VLGHGAEGTI-VYRGMFDNRDVAVKRIL--PECFSFADREVQLLRESDEHPNVIRYFCTE 71 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSED-EARFFFQQLISGVSYCHAMQVCHRDLKL 143 I +E + L E + E QQ SG+++ H++ + HRDLK Sbjct: 72 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKP 130 Query: 144 ENTLLDG-SPAPRLK--ICDFGYSKSSVLH----SQPKSTVGTPAYIAPEVLLK--KEYD 194 N L+ + ++K I DFG K + S+ GT +IAPE+L + KE Sbjct: 131 HNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENP 190 Query: 195 GKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE---- 249 D++S G Y ++ G++PF K++ R N+ + PE Sbjct: 191 TYTVDIFSAGCVFYYVISEGSHPFG---------KSLQRQANILLGACSLDCLHPEKHED 241 Query: 250 --CRHLISRIFVADPAKRISIPEIRNHEWF 277 R LI ++ DP KR S + H +F Sbjct: 242 VIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5WNL-A nrPDB Length = 342 Score = 173 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 110/278 (39%), Gaps = 23/278 (8%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKY---IERGEKIDENVKRE 65 + L D+ + + +GSG FG +R +A+K + ++ + E Sbjct: 10 ALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEE 69 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLI 125 + I+ + P + +VMEY G L E++ + D + Sbjct: 70 AKKMEMAKFRYILPVYGICQEP--VGLVMEYMETGSL-EKLLASEPLPWDLRFRIVHETA 126 Query: 126 SGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGT 179 G+++ H M + H +LK N LLD +KI DFG +K S GT Sbjct: 127 VGMNFLHCMSPPLLHLNLKPANILLDAH--YHVKISDFGLAKCNGMSHSHDLSMDGLFGT 184 Query: 180 PAYIAPEVLLKKE--YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 AY+ PE + +K +D K DV+S + ++ +L PF D + + + + + Sbjct: 185 IAYLPPERIREKSRLFDTKH-DVYSFAIVIWGVLTQKKPFADEKNILHIMMKV--VKGHR 241 Query: 238 YAIPDYVHISP----ECRHLISRIFVADPAKRISIPEI 271 +P P L+ R + ADP R + EI Sbjct: 242 PELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4PL5-B nrPDB Length = 435 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 108/270 (40%), Gaps = 31/270 (11%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVI 84 +G G G + + N VAVK I + RE+ R HPN++R+ Sbjct: 34 VLGHGAEGTI-VYKGMFDNRDVAVKRIL--PECFSFADREVQLLRESDEHPNVIRYFCTE 90 Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSED-EARFFFQQLISGVSYCHAMQVCHRDLKL 143 I +E + L E + E Q SG+++ H++ + HRDLK Sbjct: 91 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKP 149 Query: 144 ENTLLDG-SPAPRLK--ICDFGYSKSSVLH----SQPKSTVGTPAYIAPEVLLK--KEYD 194 N LL + R+K I DFG K + S+ GT +IAPE+L + K+ Sbjct: 150 HNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNP 209 Query: 195 GKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE---- 249 D++S G Y ++ G +PF K++ R N+ + + Sbjct: 210 TYTVDIFSAGCVFYYVISEGYHPFG---------KSLQRQANILLGACNLDCFHSDKHED 260 Query: 250 --CRHLISRIFVADPAKRISIPEIRNHEWF 277 R LI ++ DP +R S + H +F Sbjct: 261 VIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >3LLT-A nrPDB Length = 360 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 126/337 (37%), Gaps = 74/337 (21%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 M ++ + +++ +G G FG L + + + AVK + +K + K E + Sbjct: 27 WKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILK 86 Query: 71 SLR-----HPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFFQQ 123 ++ + NIV++ + H+ ++ E G L+E I N F ++ + + + Sbjct: 87 KIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIE 145 Query: 124 LISGVSYCHAMQVCHRDLKLENTLLDG-----------------------SPAPRLKICD 160 ++ ++Y M + H DLK EN LLD + + +K+ D Sbjct: 146 ILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLID 205 Query: 161 FGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP 220 FG + + S + T Y APEV+L +D +D+WS G L + G+ F Sbjct: 206 FGCATFKSDY--HGSIINTRQYRAPEVILNLGWDV-SSDMWSFGCVLAELYTGSLLFRTH 262 Query: 221 EEPKNFRKT---------------------------------------IHRILNVQYAIP 241 E ++ I+ I +V+ +P Sbjct: 263 EHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLP 322 Query: 242 DYVHISPE-CRHLISRIFVADPAKRISIPEIRNHEWF 277 Y I E + I DP R S E+ H++ Sbjct: 323 LYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >2Y4I-B nrPDB Length = 319 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 121/287 (42%), Gaps = 31/287 (10%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHR 70 ++ E+ + IG G FG R VA++ I+ E + KRE++ +R Sbjct: 28 WDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG-RFSEDEARFFFQQLISGVS 129 RH N+V F ++P HLAI+ G L+ + +A ++ R Q+++ G+ Sbjct: 85 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 144 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL------HSQPKSTVGTPAYI 183 Y HA + H+DLK +N D ++ I DFG S + + + G ++ Sbjct: 145 YLHAKGILHKDLKSKNVFYDN---GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 201 Query: 184 APEVLLKKEYDG--------KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILN 235 APE++ + D K +DV++ G Y + +PF+ + I ++ Sbjct: 202 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT----QPAEAIIWQMGT 257 Query: 236 VQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 + + E ++ + + +R + ++ + L+ LP Sbjct: 258 GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD---MLEKLP 301 >3LMG-A nrPDB Length = 344 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 106/265 (40%), Gaps = 24/265 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNE----LVAVKYI--ERGEKIDENVKREIINHRSLR 73 +K +GSG FG E V +K I + G + + V ++ SL Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD 91 Query: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCH 132 H +IVR + + L +V +Y G L + + + G + Q+ G+ Y Sbjct: 92 HAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 150 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVGTP-AYIAPEVLL 189 + HR+L N LL ++++ DFG + + S TP ++A E + Sbjct: 151 EHGMVHRNLAARNVLLKS--PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH 208 Query: 190 KKEYDGKVADVWSCGVTLYV-MLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHI 246 +Y + +DVWS GVT++ M GA P+ E + + R+ Q D + Sbjct: 209 FGKYTHQ-SDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMV 267 Query: 247 SPECRHLISRIFVADPAKRISIPEI 271 + + ++ D R + E+ Sbjct: 268 -------MVKCWMIDENIRPTFKEL 285 >5XD6-A nrPDB Length = 305 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 53/218 (24%), Positives = 81/218 (37%), Gaps = 19/218 (8%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNI 77 +D Y IG G++G K S + A+K ++ ++ D+ ++ LR N+ Sbjct: 21 TDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENV 79 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR---------FSEDEARFFFQQLISGV 128 V + + EYA G L + + S + G+ Sbjct: 80 VALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGL 139 Query: 129 SYCHAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAY 182 Y H V HRD+K N LL KI DF S + + +GT Y Sbjct: 140 EYLHEKANPHVIHRDIKSSNVLLFDDDVA--KIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP 220 APE + K +DV+S GV L +L G P + Sbjct: 198 HAPEYAMTGTLSTK-SDVYSFGVVLLELLTGRKPVDHT 234 >2JD5-A nrPDB Length = 373 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 118/326 (36%), Gaps = 68/326 (20%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHP---- 75 RY LV+ +G G+F L +D +N VA+K + + E + EI + + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 76 -------NIVRFKEVILTPT----HLAIVMEYASGGELFERICN--AGRFSEDEARFFFQ 122 +I++ + H+ +V E G L I + + Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIYVKQISK 138 Query: 123 QLISGVSYCHAM-QVCHRDLKLENTLLDGSPAP----RLKICDFGYSKSSVLHSQPKSTV 177 QL+ G+ Y H + H D+K EN L++ +P ++KI D G + +++ Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA--CWYDEHYTNSI 196 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP--EEPKNFRKTIHRILN 235 T Y +PEVLL + G AD+WS ++ ++ G + FE I +I+ Sbjct: 197 QTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIE 255 Query: 236 VQYAIPDY------------------VHIS----------------------PECRHLIS 255 + +P Y +IS E +S Sbjct: 256 LLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLS 315 Query: 256 RIFVADPAKRISIPEIRNHEWFLKNL 281 + DP KR + NH W L Sbjct: 316 PMLQLDPRKRADAGGLVNHPWLKDTL 341 >4WUA-A nrPDB Length = 401 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 70/362 (19%), Positives = 118/362 (32%), Gaps = 108/362 (29%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH--PN- 76 RY +++ +G G+F L D Q + VA+K ++ E E EI +S+R+ PN Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 77 -----IVRFKEVIL----TPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 +V+ + TH+ +V E G L + I N + QQ++ Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKIIQQVL 160 Query: 126 SGVSYCHAM-QVCHRDLKLENTLLDGSPAP------------------------------ 154 G+ Y H ++ H D+K EN LL + Sbjct: 161 QGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPAT 220 Query: 155 -----------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKV 197 ++KI D G + +H + T Y + EVL+ Y+ Sbjct: 221 AGNFLVNPLEPKNAEKLKVKIADLGNA--CWVHKHFTEDIQTRQYRSLEVLIGSGYNTP- 277 Query: 198 ADVWSCGVTLYVMLVGAYPFE---------DPEEPKNFRKTIHR-----ILNVQYAIP-- 241 AD+WS + + G Y FE D + + + + I+ +Y+ Sbjct: 278 ADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFF 337 Query: 242 ----------------------DYVHISPE----CRHLISRIFVADPAKRISIPEIRNHE 275 + S E + + P KR + E H Sbjct: 338 TKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHP 397 Query: 276 WF 277 W Sbjct: 398 WL 399 >2X7G-A nrPDB Length = 389 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 69/361 (19%), Positives = 118/361 (32%), Gaps = 108/361 (29%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR-----H 74 RY +++ +G G+F L D Q VA+K ++ + E EI + +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 75 PN---IVRFKEVI----LTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLI 125 PN +V+ + + H+ +V E G L + I N + +Q++ Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVL 150 Query: 126 SGVSYCHAM-QVCHRDLKLENTLLDGSPAP------------------------------ 154 G+ Y H+ ++ H D+K EN L+ A Sbjct: 151 QGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAA 210 Query: 155 ---------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 R+KI D G + +H + T Y + EVL+ Y AD Sbjct: 211 DLLVNPLDPRNADKIRVKIADLGNA--CWVHKHFTEDIQTRQYRSIEVLIGAGYSTP-AD 267 Query: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKT---IHRILNVQYAIPDYVHIS--------- 247 +WS + + G Y FE P +++ + I I+ + +IP + +S Sbjct: 268 IWSTACMAFELATGDYLFE-PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFN 326 Query: 248 -------------------------------PECRHLISRIFVADPAKRISIPEIRNHEW 276 + + + P KR S E H W Sbjct: 327 RRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPW 386 Query: 277 F 277 Sbjct: 387 L 387 >5L2Q-C nrPDB Length = 320 Score = 166 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 68/280 (24%), Positives = 114/280 (40%), Gaps = 47/280 (16%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVK-REIINHRSLRH------------PNIVRFKE 82 L R +++ +K + E+ D+ ++ +E + L H +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 83 VILT------------------PTHLAIVME-YASGG---------ELFERICNAGRFSE 114 + + +V++ + L + R SE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP- 173 E F ++ V H + HRDLKL N +L+ R+ I +F K V Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLGKHLVSEGDLL 211 Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 K G+PAYI+P+VL + Y GK +D+W+ GV L+ ML G +PF D + FRK I Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRK----I 267 Query: 234 LNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +Y IP+ +S LI ++ V DP +R++ ++ Sbjct: 268 KAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >2H34-A nrPDB Length = 309 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 97/251 (38%), Gaps = 12/251 (4%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVK----YIERGEKIDENVKREIINHRSLRHPN 76 Y L + +G G G D +VA+K + ++RE L+ P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 +V + L + M +G +L + G + A +Q+ S + HA Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 137 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEVLLKKEYD 194 HRD+K EN L+ + DFG + ++ +Q +TVGT Y+APE + + Sbjct: 156 THRDVKPENILVSADDFAY--LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-ESHA 212 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 AD+++ LY L G+ P++ + I P I +I Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRP---GIPVAFDAVI 269 Query: 255 SRIFVADPAKR 265 +R +P R Sbjct: 270 ARGMAKNPEDR 280 >5AR8-A nrPDB Length = 326 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 101/265 (38%), Gaps = 22/265 (8%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI----DENVKREIINHRSLRHPNIVR 79 ++ + G G R VAVK++ + ++V RE R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFS---EDEARFFFQQLISGVSYCHAMQ- 135 + P L IV EY G L E + + ++ GV+Y H M Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVL 188 + H DLK +N LLD +KI DFG SK ++ + GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNE--FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 189 L--KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI---HRILNVQYAIPDY 243 +K D++S V + +L PFED P ++ HR + + ++P Sbjct: 215 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYD 274 Query: 244 VHISPECRHLISRIFVADPAKRISI 268 + LI + +P +R S Sbjct: 275 IPHRARMISLIESGWAQNPDERPSF 299 >4LFI-A nrPDB Length = 374 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 113/332 (34%), Gaps = 75/332 (22%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAV------------------------KY- 51 ++ YE+ +G G + S + + K Sbjct: 38 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 97 Query: 52 ------------IERGEKIDENVKREIINHRSLRHPNIVRFKEVILTP--THLAIVMEYA 97 + E + + ++ I + H NI+ ++I P A+V EY Sbjct: 98 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 157 Query: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 + + ++ E RF+ +L+ + YCH+M + HRD+K N ++D +L+ Sbjct: 158 DN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLR 213 Query: 158 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 + D+G ++ ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 214 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 Query: 218 EDPEEPKNFRKTIHRILNVQ-----------------YAIPDYVHIS------------- 247 + I ++L Y + Y+ Sbjct: 274 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 333 Query: 248 --PECRHLISRIFVADPAKRISIPEIRNHEWF 277 E LI + D +R++ E H WF Sbjct: 334 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >4LQP-A nrPDB Length = 508 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 40/154 (25%), Positives = 71/154 (46%), Gaps = 6/154 (3%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL----RH 74 + + VK IG G FG RL++ K + ++ A+K + + E ++ + R + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 P +V +L ++ME+ GG+L + F+ED RF+ + I + H + Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 168 HR +K +N L+D +K+ DFG S Sbjct: 222 GFIHRAIKPDNILID--IRGHIKLSDFGLSTGFH 253 Score = 110 bits (276), Expect = 8e-25, Method: Composition-based stats. Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 20/189 (10%) Query: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 STVGTP YIAPE+ L + Y G+ D WS G +Y L+G PF + +RK ++ Sbjct: 321 YSTVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFE 379 Query: 234 LNVQYAIPDYVHISPECRHLISRIFVADPAKRI----SIPEIRNHEWF-------LKNLP 282 +Q+ PD +HIS E LI R+ +R+ EI++H +F ++ + Sbjct: 380 QTLQF--PDDIHISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRGVDWNTIRQVE 436 Query: 283 ADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEED 342 A + + T D P +E + + A A + GS + +D+ Sbjct: 437 APYIPKLSSIT--DTRFFPTDELENVPD--SPAMAQAAKQREQMTKQGGSAPVKEDLP-F 491 Query: 343 LESDLDDLD 351 + + D Sbjct: 492 IGYEYSRFD 500 >3UIM-A nrPDB Length = 326 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 108/278 (38%), Gaps = 28/278 (10%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE--RGEKIDENVKREIINHRSLRHP 75 SD + +G G FG R LVAVK ++ R + + + E+ H Sbjct: 29 SDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHR 87 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGE----LFERICNAGRFSEDEARFFFQQLISGVSYC 131 N++R + +TPT +V Y + G L ER + + + G++Y Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 132 HAM---QVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPE 186 H ++ HRD+K N LLD + DFG +K +T GT +IAPE Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVV--GDFGLAKLMDYKDTHVTTAVRGTIGHIAPE 205 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPF-------EDPEEPKNFRKTIHRILNVQYA 239 L + + DV+ GV L ++ G F +D ++ K + + ++ Sbjct: 206 YLSTGK-SSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEAL 264 Query: 240 IP---DYVHISPECRHLIS---RIFVADPAKRISIPEI 271 + + E LI + P +R + E+ Sbjct: 265 VDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEV 302 >5VDK-A nrPDB Length = 297 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 104/288 (36%), Gaps = 46/288 (15%) Query: 18 SDRYEL----VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK---IDENVKREIINHR 70 + RYE V+ IG G FG + + A+K + + + E+ H Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 71 SL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERI----CNAGRFSEDEARFFFQQLI 125 L HP++VR+ H+ I EY +GG L I + F E + + Q+ Sbjct: 70 VLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 126 SGVSYCHAMQVCHRDLKLENTLLDGSPAPR---------------------LKICDFGYS 164 G++Y H + H D+K N + KI D G++ Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 165 KSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPK 224 S ++PK G ++A E+L + AD+++ G+T+ V E Sbjct: 190 TSI---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAA-------GAESLP 239 Query: 225 NFRKTIHRILNVQYAIPDYV-HISPECRHLISRIFVADPAKRISIPEI 271 H I + PD +S L+ + D +R S + Sbjct: 240 TNGAAWHHIRKGNF--PDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >5E8V-A nrPDB Length = 316 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 113/301 (37%), Gaps = 48/301 (15%) Query: 14 IMHDSDRY--ELVKDIGSGNFGVARLMRDKQSN----ELVAVKYIERGEKIDENVKREII 67 MH+++ EL +G G F + KQ+ E VAVK E +++I Sbjct: 2 HMHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIF 61 Query: 68 NHRSLRHPNIVRFKEVILTPTHL----AIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 + +L+H NI++F T L ++ + + G L E + S ++ R Sbjct: 62 SDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSS 120 Query: 124 LISGVSYCHA---------MQVCHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVL 169 L G+++ H+ M + HRDLK N L+ +CDFG S SV Sbjct: 121 LARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLT--CCLCDFGLSLRLDPTLSVD 178 Query: 170 HSQPKSTVGTPAYIAPEVL-----LKKEYDGKVADVWSCGVTLYVMLVG----------A 214 VGT Y+APEVL L+ K DV+S + L+ M Sbjct: 179 DLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYE 238 Query: 215 YPFEDPEEPKNFRKTIHR---ILNVQYAIPDYVHISPECRHL---ISRIFVADPAKRISI 268 PF ++ + IP + + + ++ + DP R++ Sbjct: 239 PPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA 298 Query: 269 P 269 Sbjct: 299 Q 299 >3SV0-A nrPDB Length = 483 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 23/235 (9%) Query: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH--- 74 +++ L + IGSG+FG L + Q+NE VA+K +E + + E +R L+ Sbjct: 6 GNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRILQGGTG 64 Query: 75 -PNIVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 PN VR+ V + +VM+ S +LF + S Q+I+ V + Sbjct: 65 IPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMINRVEFV 119 Query: 132 HAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTPAY 182 H+ HRD+K +N L+ G A ++ I DFG +K + + + K+ GT Y Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARY 179 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 + L E + D+ S G L L G+ P++ + +K +I + Sbjct: 180 ASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQK-YEKISEKK 232 >3SOC-A nrPDB Length = 322 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 103/286 (36%), Gaps = 43/286 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +L++ G FG + NE VAVK +K + E+ + ++H NI++F Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 83 Query: 81 KEVILTPT----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA--- 133 T L ++ + G L + + A S +E + + G++Y H Sbjct: 84 IGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 134 -------MQVCHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYI 183 + HRD+K +N LL + I DFG + ++ VGT Y+ Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTA--CIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 184 APEVLLKKEYDGK----VADVWSCGVTLYVMLVGA-----------YPFEDPEEPKNFRK 228 APEVL + D+++ G+ L+ + PFE+ + Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 260 Query: 229 TIHRILNVQYAIPDYVHISPE------CRHLISRIFVADPAKRISI 268 + ++ + P + I + D R+S Sbjct: 261 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4M66-A nrPDB Length = 325 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 115/287 (40%), Gaps = 35/287 (12%) Query: 7 SGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI 66 +G +P + + + ++ +G G FGV + N VAVK + +KI E+ Sbjct: 9 TGASAVP-LVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-SKKISW----EV 62 Query: 67 INHRSLRHPNIVRFKEVILT--PTHL---AIVMEYASGGELFERICNAGRFSEDEARFFF 121 +LR+ N++ V + A+V + G L + Sbjct: 63 KAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLL 122 Query: 122 QQLISGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSK-------SSVLHSQ 172 Q+++ G+ Y H++ + HRDLK N LLD P K+ DFG S S S Sbjct: 123 QEVVLGMCYLHSLDPPLLHRDLKPSNILLD--PELHAKLADFGLSTFQGGSQSGSGSGSG 180 Query: 173 PKSTVGTPAYIAPEVLLKKEY-DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH 231 + + GT AY+ PE+L K K +DV+S G+ ++ +L G + E Sbjct: 181 SRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR----EAELVDKTSLIRE 236 Query: 232 RILNVQYAIP--DYVHISPE------CRHLISRIFVADPAKRISIPE 270 + + Q P + SPE + L+ + + R S + Sbjct: 237 TVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >2PMN-X nrPDB Length = 348 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 114/301 (37%), Gaps = 47/301 (15%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----------------- 61 + Y +++ + G F L + N+ A+K E+ + Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 62 -VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFER-----ICNAGR---F 112 K E+ +++ + + +I + I+ EY + + + + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFI 148 Query: 113 SEDEARFFFQQLISGVSYCH-AMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 171 + + +++ SY H +CHRD+K N L+D + R+K+ DFG S ++ Sbjct: 149 PIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKN--GRVKLSDFGES-EYMVDK 205 Query: 172 QPKSTVGTPAYIAPEVLLKKE-YDGKVADVWSCGVTLYVMLVGAYPFE-DPEEPKNFRKT 229 + K + GT ++ PE + Y+G D+WS G+ LYVM PF + F Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 230 IHRILNVQYAIPDYVH-------------ISPECRHLISRIFVADPAKRISIPEIRNHEW 276 + + +++ +S E + +PA+RI+ + HEW Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEW 325 Query: 277 F 277 Sbjct: 326 L 326 >4TN6-A nrPDB Length = 318 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 100/239 (41%), Gaps = 17/239 (7%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 + +RY L + IGSG+FG L D + E VA+K +E + + E ++ ++ Sbjct: 3 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQG 61 Query: 75 -PNIVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 I + + +VME S +LF +FS Q+IS + Y Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYI 119 Query: 132 HAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTPAY 182 H+ HRD+K +N L+ G + I DFG +K + + + K+ GT Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 + L E + D+ S G L +G+ P++ + R+ RI + + P Sbjct: 180 ASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAATK-RQKYERISEKKMSTP 236 >5FQD-C nrPDB Length = 341 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 58/237 (24%), Positives = 101/237 (42%), Gaps = 23/237 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH----P 75 +Y+LV+ IGSG+FG L + + E VAVK +E + + E ++ L+ P Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKARHPQLLYESKLYKILQGGVGIP 78 Query: 76 NIVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 +I R+ + +VM+ S +LF RF+ Q+IS + Y H Sbjct: 79 HI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRIEYVHT 133 Query: 134 MQVCHRDLKLENTLLD-GSPAPRLKICDFGYS--------KSSVLHSQPKSTVGTPAYIA 184 HRD+K +N L+ G +L + DFG + + + + + K+ GT Y + Sbjct: 134 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 193 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 L E + D+ S G L + P++ + +K +I + + P Sbjct: 194 INAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQK-YEKISEKKMSTP 248 >6BFN-A nrPDB Length = 342 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 83/226 (36%), Gaps = 26/226 (11%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKYIERG-----EKIDENVKREIINHRSLRHPNIVRF 80 IG G FG + + + AVK ++ + ++ E+ RHPNIV F Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 81 KEVILTPTHLAIVMEYASGGELFERIC----NAGRFSEDEARFFFQQLISGVSYCH--AM 134 +V + G L +R+ S + + + H + Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 135 QVCHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVGTPAYIA 184 + H D+K N LLD P K+ DFG ++ S + ++ ++ GT AY+ Sbjct: 147 SLIHGDIKSSNVLLDERLTP--KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL- 203 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI 230 PE +K D +S GV + L G + + K + Sbjct: 204 PEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 249 >4F9B-A nrPDB Length = 361 Score = 154 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 107/347 (30%), Gaps = 87/347 (25%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQS---NELVAVKYIERGEKIDENVKREIINHR 70 + S+ +++ IG G F L + E +A+K++ + E+ Sbjct: 16 VPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSH-PIRIAAELQCLT 74 Query: 71 SLR-HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 N++ K H+ I M Y + + + S E R + L + Sbjct: 75 VAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALK 131 Query: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH------------------- 170 H + HRD+K N L + + DFG ++ + Sbjct: 132 RIHQFGIVHRDVKPSNFLYNRRLKKYA-LVDFGLAQGTHDTKIELLKFVQSEAQQERCSQ 190 Query: 171 ----------SQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP 220 Q GTP + APEVL K D+WS GV +L G YPF Sbjct: 191 NKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA 250 Query: 221 EE-----------------------------------PKNFRKTIHRILNVQYAIPD--- 242 + ++ RK R+ + + P Sbjct: 251 SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS 310 Query: 243 -----------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 + + E L+ ++ +PA RI+ E H +F Sbjct: 311 DIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 >4MWI-A nrPDB Length = 294 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 96/244 (39%), Gaps = 23/244 (9%) Query: 47 VAVKYIERGE-----KIDENVKREIINHRSLRHPNIVRFKEVIL----TPTHLAIVMEYA 97 VA+K ++ + + + +EI + PNI+R + + TP +IVMEY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV--CHRDLKLENTLLDGSPAPR 155 G L E + + + G+ H + H ++ N L+ + + Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLV--TQGYQ 167 Query: 156 LKICDFGYSKSSVLHS-----QPKSTVGTPAYIAPEVLLKKEY-DGKVADVWSCGVTLYV 209 +K+ F K+ S + V + AY++P+ L Y ++++S G+ L+ Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 210 MLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIP 269 + G PF+ + RK + + P E R +I DP+ R S+ Sbjct: 228 IATGDIPFQGCNS-EKIRKLVAVKRQQE---PLGEDCPSELREIIDECRAHDPSVRPSVD 283 Query: 270 EIRN 273 EI Sbjct: 284 EILK 287 >3REP-A nrPDB Length = 271 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 106/271 (39%), Gaps = 19/271 (7%) Query: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELV-AVKYIERGEKIDENVKREIIN 68 M+ D + + + + G R + ++ +V +K + + + E Sbjct: 1 MNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPR 60 Query: 69 HRSLRHPNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDE--ARFFFQQL 124 R HPN++ +P H ++ + G L+ + F D+ A F + Sbjct: 61 LRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDM 120 Query: 125 ISGVSYCHAMQ--VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 G+++ H ++ + L + ++D R+ + D +S Q + PA+ Sbjct: 121 ARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS------FQSPGRMYAPAW 174 Query: 183 IAPEVLLKKEYDG--KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 +APE L KK D + AD+WS V L+ ++ PF D + K + ++ I Sbjct: 175 VAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVA--LEGLRPTI 232 Query: 241 PDYVHISPECRHLISRIFVADPAKRISIPEI 271 P ISP L+ DPAKR I Sbjct: 233 PP--GISPHVSKLMKICMNEDPAKRPKFDMI 261 >2QKW-B nrPDB Length = 321 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 90/269 (33%), Gaps = 31/269 (11%) Query: 27 IGSGNFGVARLMRDKQSNELVAVKYI-ERGEKIDENVKREIINHRSLRHPNIVRFKEVIL 85 IG G FG + VA+K + E + EI RHP++V Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 86 TPTHLAIVMEYASGGELFERICNAG----RFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 + ++ +Y G L + + S ++ G+ Y H + HRD+ Sbjct: 106 ERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDV 165 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLKKEYDGKVA 198 K N LLD + P KI DFG SK Q GT YI PE +K K + Sbjct: 166 KSINILLDENFVP--KITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEK-S 222 Query: 199 DVWSCGVTLYVMLVGA------YPFE---------DPEEPKNFRKTIHRILNVQYAIPDY 243 DV+S GV L+ +L P E + + + L + Sbjct: 223 DVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPESL 282 Query: 244 VHISPECRHLISRIFVADPAKRISIPEIR 272 + R S+ ++ Sbjct: 283 RKFGDTAV----KCLALSSEDRPSMGDVL 307 >5X18-A nrPDB Length = 295 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 54/232 (23%), Positives = 100/232 (43%), Gaps = 19/232 (8%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-PNIV 78 Y++ K IG G+FGV + + VA+K+ R + + ++ E ++ L PNI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQ-LRDEYKTYKILNGTPNIP 66 Query: 79 RFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 H +V++ S +LF+ +FS Q+I+ + HA + Sbjct: 67 YAYYFGQEGLHNILVIDLLGPSLEDLFDWC--GRKFSVKTVVQVAVQMITLIEDLHAHDL 124 Query: 137 CHRDLKLENTLLDGSPAP---RLKICDFGYS--------KSSVLHSQPKSTVGTPAYIAP 185 +RD+K +N L+ P + + DFG + K + + + KS GT Y++ Sbjct: 125 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 L +E + D+ + G + L G P++ + P N +K +I + Sbjct: 185 NTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQK-YEKIGEKK 234 >2QLU-A nrPDB Length = 314 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 104/287 (36%), Gaps = 44/287 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRF 80 +L++ G FG + N+ VAVK +K +REI + ++H N+++F Sbjct: 17 LQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 74 Query: 81 KEVILT----PTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA--- 133 L ++ + G L + + + +E + + G+SY H Sbjct: 75 IAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVP 133 Query: 134 --------MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAY 182 + HRD K +N LL + DFG + P VGT Y Sbjct: 134 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAV--LADFGLAVRFEPGKPPGDTHGQVGTRRY 191 Query: 183 IAPEVLLKKEYDGK----VADVWSCGVTLYVMLVGA-----------YPFEDPEEPKNFR 227 +APEVL + D+++ G+ L+ ++ PFE+ Sbjct: 192 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 251 Query: 228 KTIHRIL---NVQYAIPDYVHISPECRHL---ISRIFVADPAKRISI 268 + + ++ ++ I D+ P L I + D R+S Sbjct: 252 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4BTK-A nrPDB Length = 337 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 96/250 (38%), Gaps = 19/250 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHP-NI 77 DR++++K IG G FG D + E VA+K +E ++ + +K E+ + L+ ++ Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 RF +VM+ G L + R G F+ +Q++ + H++ Sbjct: 115 CRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVG 173 Query: 136 VCHRDLKLENTLLDGSPAPRLK--ICDFGYSKSSV-------LHSQPKSTVGTPAYIAPE 186 HRD+K N + P+ K + DFG ++ GT Y + Sbjct: 174 FLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVN 233 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 +E G+ D+WS L VG P+ ++ + + + H+ Sbjct: 234 AHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML----LKHM 288 Query: 247 SPECRHLISR 256 E + Sbjct: 289 PSEFHLFLDH 298 >4NFN-A nrPDB Length = 309 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 96/250 (38%), Gaps = 19/250 (7%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHP-NI 77 DR++++K IG G FG D + E VA+K +E ++ + +K E+ + L+ ++ Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 78 VRFKEVILTPTHLAIVMEYASGGELFE--RICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 RF +VM+ G L + R G F+ +Q++ + H++ Sbjct: 80 CRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVG 138 Query: 136 VCHRDLKLENTLLDGSPAPRLK--ICDFGYSKSSV-------LHSQPKSTVGTPAYIAPE 186 HRD+K N + P+ K + DFG ++ GT Y + Sbjct: 139 FLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVN 198 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 +E G+ D+WS L VG P+ ++ + + + H+ Sbjct: 199 AHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML----LKHM 253 Query: 247 SPECRHLISR 256 E + Sbjct: 254 PSEFHLFLDH 263 >2CMW-A nrPDB Length = 310 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 100/235 (42%), Gaps = 20/235 (8%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH--PNIVR 79 + K IG GNFG RL ++ +NE VA+K +E + + E ++ L + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 80 FKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVC 137 + A+V+E S +LF+ F+ QL+S + Y H+ + Sbjct: 62 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 138 HRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTVGTPAYIAPE 186 +RD+K EN L+ + + I DFG +K + + + KS GT Y++ Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 L KE + D+ + G L G+ P++ + ++ +I + + P Sbjct: 180 THLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRNTP 232 >2CHL-A nrPDB Length = 351 Score = 146 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 58/236 (24%), Positives = 100/236 (42%), Gaps = 19/236 (8%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RHPNIV 78 + + K IG GNFG RL ++ +NE VA+K +E + + E ++ L I Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 79 RFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 + + A+V+E S +LF+ FS QLIS + Y H+ + Sbjct: 90 QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 137 CHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTVGTPAYIAP 185 +RD+K EN L+ + I DF +K + + + KS GT Y++ Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 L KE + D+ + G L G+ P++ + ++ +I + + A P Sbjct: 208 NTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATP 261 >1CSN-A nrPDB Length = 298 Score = 146 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 103/238 (43%), Gaps = 23/238 (9%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH----P 75 Y++ + IG G+FGV + +N+ VA+K+ R + ++ E ++ L P Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQ-LRDEYRTYKLLAGCTGIP 69 Query: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQLISGVSYCHAM 134 N+ H +V++ G L + + GR FS +Q+++ V H Sbjct: 70 NV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEK 125 Query: 135 QVCHRDLKLENTLL---DGSPAPRLKICDFGY--------SKSSVLHSQPKSTVGTPAYI 183 + +RD+K +N L+ + A + + DFG +K + + + K+ GT Y+ Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 + L +E + D+ + G L G+ P++ + N +K RI + + P Sbjct: 186 SINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQK-YERIGEKKQSTP 241 >5X1R-A nrPDB Length = 302 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 101/287 (35%), Gaps = 36/287 (12%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK---------------YIERG 55 LP + + +E+ + IG G FG+ D Q +A+K RG Sbjct: 13 SLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRG 72 Query: 56 EKIDENVK-------REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFER-IC 107 E+ + + +E HP ++ + ++ SG L Sbjct: 73 ERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQ 132 Query: 108 NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 + E R L S ++ H HRD+ L+N + S P + DFG ++ Sbjct: 133 QPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV--LLDFGSARKE 190 Query: 168 VLHSQPKSTVGTPAYIAPEVLLKKEYDGKV---ADVWSCGVTLYVMLVGAYPFEDPEEPK 224 + + ++ + AP + DG+ D+++ G L+ ++VG+ P P Sbjct: 191 IGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP------PV 244 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI-SIPE 270 + ++I SPE + R P R +I E Sbjct: 245 SVVRSIEDSYQP-LTERRPAGYSPELLRTVDRALALKPEDRPQTIDE 290 >2C47-A nrPDB Length = 313 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 57/236 (24%), Positives = 101/236 (42%), Gaps = 19/236 (8%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH-PNIV 78 + + K IG GNFG RL ++ +NE VA+K +E + + E ++ L + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 79 RFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 + + A+V+E S +LF+ F+ QLI+ + Y H + Sbjct: 64 QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 137 CHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTVGTPAYIAP 185 +RD+K EN L+ R + I DFG +K + + + KS GT Y++ Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 186 EVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 L KE + D+ + G L G+ P++ + ++ +I + + A P Sbjct: 182 NTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATP 235 >4NT4-A nrPDB Length = 312 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 103/244 (42%), Gaps = 29/244 (11%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSL-RH---- 74 + + K IG GNFG RL ++ +NE VA+K K + + E ++ L H Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQ-LHLEYRFYKLLGSHADNA 71 Query: 75 ----PNIVRFKEVILTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGV 128 P I + A+V+E S +LF +FS +QL+ + Sbjct: 72 PDGIPRIYHL-GTC-GGRYNAMVLELLGLSLEDLFNICAR--KFSLKTVLMIAKQLLHRI 127 Query: 129 SYCHAMQVCHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTV 177 Y H+ + +RD+K EN L+ + R + I DFG +K + + + KS Sbjct: 128 EYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLT 187 Query: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ 237 GT Y++ + +E + D+ + G L G+ P++ + ++ +I + + Sbjct: 188 GTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTK 245 Query: 238 YAIP 241 A P Sbjct: 246 RATP 249 >4M69-B nrPDB Length = 283 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 93/243 (38%), Gaps = 23/243 (9%) Query: 47 VAVKYIERGEKIDENVKR-----EIINHRSLRHPNIVRFKEVILT----PTHLAIVMEYA 97 V +K + + R EI + PNI+R + + P +IVMEY Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 G L E + + + G+ H + HR++ + L+ G ++K Sbjct: 95 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAG--GYQVK 152 Query: 158 ICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLK--KEYDGKVADVWSCGVTLYVM 210 + F SK+ S+ + Y++PE L YD K A+++S G+ L+ + Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK-AEIYSFGIVLWEI 211 Query: 211 LVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPE 270 G PFE + +K + + P R +I+ +P++R S+ Sbjct: 212 ATGKIPFEGCDS----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 267 Query: 271 IRN 273 I Sbjct: 268 ILE 270 >4BTF-A nrPDB Length = 469 Score = 143 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 93/243 (38%), Gaps = 23/243 (9%) Query: 47 VAVKYIERGEKIDENVKR-----EIINHRSLRHPNIVRFKEVILT----PTHLAIVMEYA 97 V +K + + R EI + PNI+R + + P +IVMEY Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 G L E + + + G+ H + HR++ + L+ G ++K Sbjct: 281 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAG--GYQVK 338 Query: 158 ICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLK--KEYDGKVADVWSCGVTLYVM 210 + F SK+ S+ + Y++PE L YD K A+++S G+ L+ + Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK-AEIYSFGIVLWEI 397 Query: 211 LVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPE 270 G PFE + +K + + P R +I+ +P++R S+ Sbjct: 398 ATGKIPFEGCDS----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 453 Query: 271 IRN 273 I Sbjct: 454 ILE 456 >3QD2-B nrPDB Length = 332 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 54/329 (16%), Positives = 96/329 (29%), Gaps = 85/329 (25%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG------------------------ 55 +E ++ +G G FGV ++K + A+K I Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 56 --------EKIDENVKRE---------------------------IINHRSLRHPNIVRF 80 E E + E I N V Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 81 KEVILTPTHLAIVMEYASGGELFERICNAGRFSEDE---ARFFFQQLISGVSYCHAMQVC 137 + +L I M+ L + + + E F Q+ V + H+ + Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 138 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-------------PKSTVGTPAYIA 184 HRDLK N +K+ DFG + + VGT Y++ Sbjct: 187 HRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE + Y K D++S G+ L+ +L + I + N+++ + Sbjct: 245 PEQIHGNNYSHK-VDIFSLGLILFELLY------SFSTQMERVRIITDVRNLKFPLLFTQ 297 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRN 273 E ++ + P +R +I Sbjct: 298 KYPQE-HMMVQDMLSPSPTERPEATDIIE 325 >3G2F-A nrPDB Length = 336 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 100/308 (32%), Gaps = 58/308 (18%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR--SLRH 74 D D +L++ IG G +G VAVK +N E +R + H Sbjct: 11 DLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFS--FANRQNFINEKNIYRVPLMEH 66 Query: 75 PNIVRFK---EVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 NI RF E + + +VMEY G L + + + + G++ Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTRGLA 125 Query: 130 YCHAM---------QVCHRDLKLENTLLDGSPAPRLKICDFGYS---------KSSVLHS 171 Y H + HRDL N L+ I DFG S + + Sbjct: 126 YLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV--ISDFGLSMRLTGNRLVRPGEEDN 183 Query: 172 QPKSTVGTPAYIAPEVLLKK------EYDGKVADVWSCGVTLYVMLVGAY-PFEDPEEPK 224 S VGT Y+APEVL E K D+++ G+ + + + F P+ Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPE 243 Query: 225 ---------------NFRKTIHRILNVQYAIPD-YVHISPECRHL---ISRIFVADPAKR 265 + + + P+ + S R L I + D R Sbjct: 244 YQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEAR 303 Query: 266 ISIPEIRN 273 ++ Sbjct: 304 LTAQCAEE 311 >4L00-A nrPDB Length = 304 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 95/272 (34%), Gaps = 34/272 (12%) Query: 24 VKDIGSGN-----FGVARLMRDKQS-----NELVAVKYIERGEK-IDENVKREIINHRSL 72 + +G G G +D + V +K ++ + I R + Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNA-GRFSEDEARFFFQQLISGVSYC 131 H +IV V + +V E+ GG L + + +QL S +SY Sbjct: 90 SHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYL 149 Query: 132 HAMQVCHRDLKLENTLL-----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 186 + H ++ +N LL D P +K+ D G + + + + +IAPE Sbjct: 150 EDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI---PWIAPE 206 Query: 187 VLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 + + AD WS G TL+ + G P +D I ++ Sbjct: 207 CVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKT----------LIEKERFYESRCRP 256 Query: 246 ISPECR---HLISRIFVADPAKRISIPEIRNH 274 ++P C+ L++R DP +R I Sbjct: 257 VTPSCKELADLMTRCMNYDPNQRPFFRAIMRD 288 >5J0A-A nrPDB Length = 300 Score = 141 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 93/279 (33%), Gaps = 37/279 (13%) Query: 31 NFGV---ARLMRDKQSNE---LVAVKYIER------GEKIDENVKREIINHRSLRHPNIV 78 FG LM+ AVK I + + E +SL HPNIV Sbjct: 18 GFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIV 77 Query: 79 RFKEVIL-TPTHLAIVMEYASGGELFERICNA-----GRFSEDEARFFFQQLISGVSYCH 132 ++ L + MEY L + I F + G+ Y H Sbjct: 78 GYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLH 137 Query: 133 A-MQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS----TVGTPAYIAPEV 187 ++ H D+K N ++ G +KICD G S + + +GT + E Sbjct: 138 QEKKLLHGDIKSSNVVIKGDFET-IKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEA 196 Query: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYP-----------FEDPEEPKNFRKTIHRILNV 236 + + AD+++ G+TL+ M+ + P + +E + + L Sbjct: 197 VEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGT 256 Query: 237 QYAI--PDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 + I + + L S DP R S I Sbjct: 257 RPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >5M07-A nrPDB Length = 276 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 53/268 (19%), Positives = 92/268 (34%), Gaps = 42/268 (15%) Query: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER----GEKIDENVKREIINHRSLRHPN 76 Y +V+ +G+ G L++ A+K + ++ +RE L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAM 134 I+ + L I M+Y G + + + + E + + Y H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 135 QVCHRDLKLENTLLDGSPAP--RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 + HRD+ N +L A R+ + DFG + P+Y APE+ + Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSAGAD 198 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 DG+ AD ++ +T + GA P + P P+ Sbjct: 199 VDGR-ADQYALALTAIHLFAGAPPVDRSHT-------------GPLQPPKLSAFRPDLAR 244 Query: 253 L---ISRIFVADPAKRIS----IPEIRN 273 L +SR PA R + N Sbjct: 245 LDGVLSRALATAPADRFGSCREFADAMN 272 >3HNG-A nrPDB Length = 360 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 40/169 (23%), Positives = 74/169 (43%), Gaps = 11/169 (6%) Query: 109 AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 168 + ++ + Q+ G+ + + + HRDL N LL + +KICDFG ++ Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV--VKICDFGLARDIY 250 Query: 169 LHSQPKSTVGTP---AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPK 224 + T ++APE + K Y K +DVWS GV L+ + G P+ + + Sbjct: 251 KNPDYVRKGDTRLPLKWMAPESIFDKIYSTK-SDVWSYGVLLWEIFSLGGSPYPGVQMDE 309 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 +F + ++ P+Y +PE ++ + DP +R E+ Sbjct: 310 DFCSRLRE--GMRMRAPEYS--TPEIYQIMLDCWHRDPKERPRFAELVE 354 Score = 75.3 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 38/109 (34%), Gaps = 9/109 (8%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDE--NVKRE 65 +R +L K +G G FG + + VAVK ++ G E + E Sbjct: 21 KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTE 80 Query: 66 IINHRSL-RHPNIVRFKEVIL-TPTHLAIVMEYASGGELFERICNAGRF 112 + + H N+V L +++EY G L + + Sbjct: 81 LKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >3VHK-A nrPDB Length = 368 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 72/170 (42%), Gaps = 11/170 (6%) Query: 109 AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSK--- 165 + + + Q+ G+ + + + HRDL N LL +KICDFG ++ Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNV--VKICDFGLARDIY 251 Query: 166 SSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPK 224 + + ++APE + + Y + +DVWS GV L+ + GA P+ + + Sbjct: 252 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQ-SDVWSFGVLLWEIFSLGASPYPGVKIDE 310 Query: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 F R L + + +PE + + +P++R + E+ H Sbjct: 311 EF----CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 74.1 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 39/107 (36%), Gaps = 9/107 (8%) Query: 13 PIMHDSDRYELVKDIGSGNFGVARLM-----RDKQSNELVAVKYIERGEKIDEN--VKRE 65 DR +L K +G G FG + VAVK ++ G E+ + E Sbjct: 23 KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSE 82 Query: 66 IINHRSL-RHPNIVRFKEVILTP-THLAIVMEYASGGELFERICNAG 110 + + H N+V P L +++E+ G L + + Sbjct: 83 LKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 129 >4XHH-A nrPDB Length = 403 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 93/238 (39%), Gaps = 17/238 (7%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 + ++ + + IGSG+FG + S E VA+ +E + E ++ L Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSG 61 Query: 75 PNIVRFKEVI-LTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + F + A+V++ S +LF +FS Q+I V Y Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--KFSFKTVIMLALQMICRVQYI 119 Query: 132 HAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKSTVGTPAY 182 H HRD+K +N L+ G + + DFG SK + + + KS GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAI 240 + L E + D+ S G L G+ P++ + ++ RIL + I Sbjct: 180 ASVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLK-ATTKKQKYDRILEKKLCI 235 >2PZI-A nrPDB Length = 681 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 100/276 (36%), Gaps = 42/276 (15%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQ-SNELVAVKYI--------ERGEKID 59 P P + +YE+ I G G L D+ + V +K + + + Sbjct: 70 PQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE 129 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSE 114 E++ HP+IV+ + IVMEY G L + Sbjct: 130 RQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPV 181 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 174 EA + +++ +SY H++ + + DLK EN +L +LK+ D G + + Sbjct: 182 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLG---AVSRINSFG 235 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 GTP + APE++ D+++ G TL + + P + + + Sbjct: 236 YLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAALT--------LDLPTRNGRYVDGLP 285 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPE 270 + Y L+ R DP +R + E Sbjct: 286 EDDPVLKTYDSYGR----LLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 100/276 (36%), Gaps = 42/276 (15%) Query: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQ-SNELVAVKYI--------ERGEKID 59 P P + +YE+ I G G L D+ + V +K + + + Sbjct: 109 PQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE 168 Query: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHL-----AIVMEYASGGELFERICNAGRFSE 114 E++ HP+IV+ + IVMEY G L + Sbjct: 169 RQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPV 220 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 174 EA + +++ +SY H++ + + DLK EN +L +LK+ D G + + Sbjct: 221 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLG---AVSRINSFG 274 Query: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 GTP + APE++ D+++ G TL + + P + + + Sbjct: 275 YLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAALT--------LDLPTRNGRYVDGLP 324 Query: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPE 270 + Y L+ R DP +R + E Sbjct: 325 EDDPVLKTYDSYGR----LLRRAIDPDPRQRFTTAE 356 >4XHL-A nrPDB Length = 394 Score = 135 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 101/260 (38%), Gaps = 25/260 (9%) Query: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH 74 + ++ + + IGSG+FG + S E VA+ +E + E +R L Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSG 61 Query: 75 PNIVRFKEVI-LTPTHLAIVMEYA--SGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 + F + A+V++ S +LF RFS Q+ + Y Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYI 119 Query: 132 HAMQVCHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKSTVGTPAY 182 H HRD+K +N L+ G + + DFG SK + + + KS GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED---PEEPKNFRKTIHRILNVQYA 239 + L E + D+ S G L G+ P++ + + + + + + LNV Sbjct: 180 ASVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVE 238 Query: 240 -----IP-DYVHISPECRHL 253 +P ++ C++L Sbjct: 239 TLCSGLPLEFQEYMAYCKNL 258 >5USZ-A nrPDB Length = 289 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 94/292 (32%), Gaps = 26/292 (8%) Query: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNE-------LVAVKYIERGEK-IDENVKRE 65 ++ + +G G F ++ + V +K +++ + E+ Sbjct: 3 HKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEA 62 Query: 66 IINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR-FSEDEARFFFQQL 124 L H ++V V + +V E+ G L + + +QL Sbjct: 63 ASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQL 122 Query: 125 ISGVSYCHAMQVCHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPKSTVG 178 + + + + H ++ +N LL P +K+ D G S + + + + Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI- 181 Query: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY 238 ++ PE + + D WS G TL+ + G + + RK Q Sbjct: 182 --PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGD--KPLSALDSQRKLQFYEDRHQL 237 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNT 290 P E +LI+ +P R S I DL+ + Sbjct: 238 PAPKAA----ELANLINNCMDYEPDHRPSFRAIIRD--LNSLFTPDLVPRGS 283 >4RT7-A nrPDB Length = 415 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 80/213 (37%), Gaps = 19/213 (8%) Query: 64 REIINHRSLRHPNIVRFKE-VILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 RE+ H I + + EY + E + + ++ F Sbjct: 198 REVQIHP--DSDQISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLCFAY 250 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGT 179 Q+ G+ + HRDL N L+ +KICDFG ++ + S + Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTH--GKVVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQY 238 ++APE L + Y K +DVWS G+ L+ + G P+ NF K I + Sbjct: 309 VKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN----GF 363 Query: 239 AIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 + + + E ++ + D KR S P + Sbjct: 364 KMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 90.7 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 38/108 (35%), Gaps = 8/108 (7%) Query: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRD---KQSNE--LVAVKYIERGEKIDEN--VK 63 DL + E K +GSG FG ++ VAVK ++ E + Sbjct: 57 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 116 Query: 64 REIINHRSL-RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAG 110 E+ L H NIV + ++ EY G+L + + Sbjct: 117 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 164 >5C01-A nrPDB Length = 342 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 84/248 (33%), Gaps = 23/248 (9%) Query: 38 MRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEY 96 RD+ V +K ++ I + H ++ V + +V EY Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 160 Query: 97 ASGGELFERICN-AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTL-----LDG 150 G L + G QQL S +SY + H ++ N L L Sbjct: 161 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 220 Query: 151 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD-GKVADVWSCGVTLYV 209 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 221 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 277 Query: 210 MLV-GAYPFE--DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 + G P + P E ++F + HR+ + + P L S+ +P +R Sbjct: 278 ICFDGEAPLQSRSPSEKEHFYQRQHRL--PEPSCPQLAT-------LTSQCLTYEPTQRP 328 Query: 267 SIPEIRNH 274 S I Sbjct: 329 SFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 84/248 (33%), Gaps = 23/248 (9%) Query: 38 MRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEY 96 RD+ V +K ++ I + H ++ V + +V EY Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 137 Query: 97 ASGGELFERICN-AGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTL-----LDG 150 G L + G QQL S +SY + H ++ N L L Sbjct: 138 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 197 Query: 151 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD-GKVADVWSCGVTLYV 209 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 198 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 254 Query: 210 MLV-GAYPFE--DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRI 266 + G P + P E ++F + HR+ + + P L S+ +P +R Sbjct: 255 ICFDGEAPLQSRSPSEKEHFYQRQHRL--PEPSCPQLAT-------LTSQCLTYEPTQRP 305 Query: 267 SIPEIRNH 274 S I Sbjct: 306 SFRTILRD 313 >5OAT-A nrPDB Length = 411 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 107/308 (34%), Gaps = 66/308 (21%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSNE-----LVAVKYIERGEKIDE------------- 60 + L K I G GV + K A+K + + + Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 61 ------------NVKREIINHRSLR--HPNIVRFKEVILTPTHLAIVMEYASGG-----E 101 N + E+ N R HPNIV V A+ G Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 102 LFERICNAG---------RFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGS- 151 LF + S + QL+ GV++ A + HRDLK +N LLD S Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 152 -PAPRLKICDFG--YSKSSVLHSQPKSTV-----GTPAYIAPEVLLKKEYDG-----KVA 198 +P L I DFG + + S P ++ G A +APE++ +K A Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKA 250 Query: 199 DVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIF 258 D+W+ G Y + PF P KNF + + +P + + L++ + Sbjct: 251 DLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVI------QALVANLL 304 Query: 259 VADPAKRI 266 +P KR+ Sbjct: 305 KRNPNKRL 312 >4JRN-A nrPDB Length = 372 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 94/294 (31%), Gaps = 57/294 (19%) Query: 26 DIGSGNFGVARLMRDKQSNELVAVKY-IERGEKIDE---NVKREIINHRSLR-------- 73 +GSG F D ++NE +AVK + E DE +++RE +R+ Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 74 ---HPNIVR---------------FKEVILTPTHLAIVMEYASGGELFERIC-------- 107 +V + ++ + ++ + I Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 108 NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSS 167 N F + Q I V+ A + H D+K N LL RL + DFG + Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKD--GRLFLGDFGTYR-- 250 Query: 168 VLHSQPKSTVGTPAYIAPEVLLKKEY--DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKN 225 +++ +GTP Y PE + D W G+TLY + P Sbjct: 251 -INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP----TPADG 305 Query: 226 FRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 +H D + LI + DP KR+ + F + Sbjct: 306 IWDYLHFA--------DCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKE 351 >5UV4-A nrPDB Length = 311 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 44/203 (21%), Positives = 76/203 (37%), Gaps = 14/203 (6%) Query: 25 KDIGSGNFGVARLMRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPNIVRFKEV 83 + IG G + + ++ VK+++ G K + REI S+RHPN+V + Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGY 89 Query: 84 ILTPT--HLAIVMEYASGGELFERI-----CNAGRFSEDEARFFFQQLISGVSYCHAMQV 136 P ++ +YA L + N S + + + Y H +V Sbjct: 90 YWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERV 149 Query: 137 C-HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPE-VLLKKE 192 H ++K N L+ S L + D+ + + + G Y PE K Sbjct: 150 IPHGNIKSSNVLIQNSTPSAL-VTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208 Query: 193 YDGKVADVWSCGVTLYVMLVGAY 215 +DV++ GV L +L G Sbjct: 209 CPSLKSDVYAFGVILLELLTGKI 231 >6EQI-C nrPDB Length = 433 Score = 108 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 70/360 (19%), Positives = 113/360 (31%), Gaps = 88/360 (24%) Query: 19 DRYELVKDIGSGNFGVARLMRDKQSN-----ELVAVKYI------ERGEKIDENVKRE-- 65 D +L + I G V + K +AVK + I + + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 66 -------------IINHRSLR-----HPNIVRFKEVILTPTH------------------ 89 I N + HPNIVR V Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 90 ---------LAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRD 140 L +VM+ L E + + + + QL+ V++ + + HRD Sbjct: 135 PEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISHRD 192 Query: 141 LKLENTLLD---GSPAPRLKICDFGYSKSSVLH-------SQPKSTVGTPAYIAPEVLLK 190 LK +N L+D G P + I DFG + S+ + G A +APE+ Sbjct: 193 LKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANA 252 Query: 191 KEYDG-----KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 K K +D+W+ G Y + PF D ++L+ Y D Sbjct: 253 KPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT---------MKLLSKSYKEEDLPE 303 Query: 246 ISPE----CRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQP 301 + R+L+S + KR+ P+ + +N +E Q Sbjct: 304 LPDTIPFIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSSWLKENYTLPNSNEIIQW 363 >4I94-A nrPDB Length = 300 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 75/241 (31%), Gaps = 19/241 (7%) Query: 34 VARLMRDKQSNELVAVKYIERGE-KIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAI 92 V + ++ +AVK R E LR+ + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLL 102 Query: 93 VMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYCHAMQ-VCHRDLKLENTLLD 149 + E+ L + + + + + + YC + + DL L D Sbjct: 103 IAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFD 162 Query: 150 GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYV 209 PRL FG K+S + A+ PE L + ++S G L Sbjct: 163 DDANPRLSC--FGLMKNSRDGKSYST---NLAFTPPEYLRTGRVTPESV-IYSFGTLLLD 216 Query: 210 MLVGA--YPFE--DPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKR 265 +L G P D +N + + L Q++ D E L SR +P +R Sbjct: 217 LLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDD----GTELIRLASRCLQYEPRER 272 Query: 266 I 266 Sbjct: 273 P 273 >4L68-A nrPDB Length = 340 Score = 104 bits (259), Expect = 8e-23, Method: Composition-based stats. Identities = 38/190 (20%), Positives = 64/190 (33%), Gaps = 13/190 (6%) Query: 33 GVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAI 92 G +AVK++ + + + E+ LRH N+ + + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFL 112 Query: 93 VMEYASGGELFERI-CNAGRFSEDEARFFFQQLISGVSYCHA---MQVCHRDLKLENTLL 148 V +Y S G L + N G G+++ H + H+++ L+ Sbjct: 113 VYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILI 172 Query: 149 DGSPAPRLKICDFGYSKSSVL-----HSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSC 203 D R I D G ++ V S +G Y+APE DV+ Sbjct: 173 DEDFDAR--IIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLKGDVYGL 229 Query: 204 GVTLYVMLVG 213 GV L + G Sbjct: 230 GVVLLELATG 239 >6J6I-B nrPDB Length = 351 Score = 98.8 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 77/197 (39%), Gaps = 20/197 (10%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVK-REIIN-----HRSLRHPNIVRFKEVILTPTH 89 + R + + +K E + + +E+ N R H N ++ L Sbjct: 73 KWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPF 132 Query: 90 LAIVMEYASGGELFER---ICNAGR--FSEDEARFFFQQLISGVSYCHA---MQVCHRDL 141 +V E+A G + +R I N +++ + V+Y H + HRD+ Sbjct: 133 PVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDV 192 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVLLKKEYDGKVA 198 K + LD + K+ D +S S + + +GT YI P + K + + Sbjct: 193 KPMHVFLDKNWTA--KLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYT 249 Query: 199 DVWSCGVTLYVMLVGAY 215 DV+S G+ L V++ G Sbjct: 250 DVYSFGICLLVIITGKP 266 >5UU1-A nrPDB Length = 324 Score = 94.1 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 85/236 (36%), Gaps = 39/236 (16%) Query: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVA---VKY-----------------IERGE 56 + +++ L K IGSG FG+ L E A VK + + + Sbjct: 14 EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKD 73 Query: 57 KIDENVKREIINHRSLRHPNIVRFKEVILTP----THLAIVMEYASGGELFERICNAGRF 112 I + ++R + L + I F LT ++ +VME G +L + G F Sbjct: 74 CIKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTF 127 Query: 113 SEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 172 + +++ + Y H + H D+K N LL ++ + D+G S + Sbjct: 128 KKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGN 187 Query: 173 P--------KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDP 220 K GT + + + + +DV G + L G P+E Sbjct: 188 HKQYQENPRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLPWEQN 242 >4IX6-A nrPDB Length = 350 Score = 88.4 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 98/341 (28%), Gaps = 73/341 (21%) Query: 5 AVSGPMDL---PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN 61 A GP L P + D L +GSGNFG K ++V ++ + Sbjct: 3 ARGGPKTLRRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMA 58 Query: 62 VKREIINHRSLR---HPN----IVRFKEVILTPTH-------------LAIVMEYASGGE 101 + + + H N RF I L + M G Sbjct: 59 AEELLECEMDVNYHVHANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWL-MWANEGEN 117 Query: 102 LFERICNAGRFSEDEA------------RFFFQQLISGVSYCHAMQVCHRDLKLENTLLD 149 E + G A + ++L+ ++ H V HRD+K N + Sbjct: 118 TVEALMRRGTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAA 177 Query: 150 GSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTPAYI-APEVLLKKEYDGKVA----- 198 LK+ D G + + + + P Y A E+ L + Sbjct: 178 EKDGGVLKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAA 237 Query: 199 -----------DVWSCGVTLYVMLV-------GAYPFEDPEEPKNFRKTIHRILN-VQYA 239 D WS G + + V G F + + R +Y Sbjct: 238 KLWEAHKPDRFDSWSAGCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYG 297 Query: 240 IPDYVHISPEC---RHLISRIFVADPAKRISIPEIRNHEWF 277 D+ + L R+ A+ R S +H +F Sbjct: 298 TMDFAALDANGGAGWDLCQRLMEAERDARASCEAALSHAFF 338 >2RSV-A nrPDB Length = 403 Score = 88.4 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 94/278 (33%), Gaps = 53/278 (19%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELV------AVK-------------YIERGEKIDE 60 +++ IG G FG L D S+E V VK + E Sbjct: 43 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 101 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPT----HLAIVMEYASGGELFERIC--NAGRFSE 114 +++ I R L++ + ++ L + ++M+ G ++I NA RFS Sbjct: 102 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFSR 158 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 174 +++ + Y H + H D+K N LL+ ++ + D+G + K Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 218 Query: 175 STV--------GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 GT + + + + D+ G + L G P+ED Sbjct: 219 EYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDN------ 271 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAK 264 + + +Y + L+ + F P K Sbjct: 272 ------LKDPKYVRDSKIRYRENIASLMDKCF---PEK 300 >2LAV-A nrPDB Length = 361 Score = 87.2 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 94/278 (33%), Gaps = 53/278 (19%) Query: 20 RYELVKDIGSGNFGVARLMRDKQSNELV------AVK-------------YIERGEKIDE 60 +++ IG G FG L D S+E V VK + E Sbjct: 36 EWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 Query: 61 NVKREIINHRSLRHPNIVRFKEVILTPT----HLAIVMEYASGGELFERIC--NAGRFSE 114 +++ I R L++ + ++ L + ++M+ G ++I NA RFS Sbjct: 95 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFSR 151 Query: 115 DEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 174 +++ + Y H + H D+K N LL+ ++ + D+G + K Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 Query: 175 STV--------GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNF 226 GT + + + + D+ G + L G P+ED Sbjct: 212 EYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDN------ 264 Query: 227 RKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAK 264 + + +Y + L+ + F P K Sbjct: 265 ------LKDPKYVRDSKIRYRENIASLMDKCF---PEK 293 >5CLR-A nrPDB Length = 451 Score = 86.4 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 71/198 (35%), Gaps = 22/198 (11%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTH--LAIV 93 + + +K ++ + E L R I+ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHYIL 150 Query: 94 MEYASGGELFERICNAGRFSED-----EARFFFQQLISGVSYCHAMQVCHRDLKLENTLL 148 + G +L R NA + + E + V H + + HRDLK N +L Sbjct: 151 TTFIKGIDL-SRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209 Query: 149 DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD--GKVADVWSCGVT 206 D + DFG S S ++ GT +Y+APE+ ++++ +V+D+++ + Sbjct: 210 DADMQCH--LVDFGSSSS--DKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYS 265 Query: 207 LYVMLVGAYPFEDPEEPK 224 L + PF + K Sbjct: 266 LDELFN---PFRQVKFAK 280 >5DMZ-A nrPDB Length = 365 Score = 82.6 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 51/296 (17%), Positives = 89/296 (30%), Gaps = 57/296 (19%) Query: 12 LPIMHDSDRYELVKDI-------GSGNFGVARLMR-----DKQSNELVAVKYIERGEKID 59 LP + ++L + G G F D ++ + +K + Sbjct: 51 LPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV--QKPANP 108 Query: 60 ENVKREIINHRSLR----HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSED 115 L+ H ++F L +V E S G L I E Sbjct: 109 WEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEK 167 Query: 116 E-----ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDG---------SPAPRLKICDF 161 F +++ + H ++ H D+K +N +L + L + D Sbjct: 168 VMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDL 227 Query: 162 GYS---KSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAY--- 215 G S K + + T + E+L K ++ D + T+Y ML G Y Sbjct: 228 GQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWN-YQIDYFGVAATVYCMLFGTYMKV 286 Query: 216 -----------PFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA 260 F + + H +LN IPD H+ L+ + Sbjct: 287 KNEGGECKPEGLFRRLPHLDMWNEFFHVMLN----IPDCHHLPS--LDLLRQKLKK 336 >6G4J-A nrPDB Length = 315 Score = 81.8 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 70/211 (33%), Gaps = 32/211 (15%) Query: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRS 71 + + + Y L K +G G G+ L S+ VA+K ++ E+ +S Sbjct: 19 IKGKWNGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV----SDDSLSITSEVNVLKS 72 Query: 72 LRHPNIVRFKEVILTPTHLAI----------VMEYASGGELFERICNAGRFSEDEARFFF 121 V I MEY G L + + + G + Sbjct: 73 FSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLM 129 Query: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 181 QL+S +S H DLK +N ++ G P R++ D G + + + Sbjct: 130 IQLLSSLSVLHQQGWIFGDLKPDNLIVTG-PPARIRCIDVGGTTKEGRAIKEYTEFYDRG 188 Query: 182 YIAPEVLLKKEYDGKVA----DVWSCGVTLY 208 Y Y + A D+++ + + Sbjct: 189 Y--------WGYGTRKAEPSYDLFAVAMIMI 211 >4O1O-A nrPDB Length = 717 Score = 80.6 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 84/243 (34%), Gaps = 52/243 (21%) Query: 44 NELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVILTPTHLAIVMEYASGGEL 102 ++ VAVK G ++E+ +S R + N+V F + L + + L Sbjct: 369 DQEVAVKRFSEG---STRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY-TL 424 Query: 103 FERICNAG----RFSEDE-ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 E + N EDE AR L + H H+DL+ +N L+D Sbjct: 425 QEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-- 482 Query: 158 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCG-VTLYVMLVGAYP 216 + DF S Q D+ + G + LYV+ G Sbjct: 483 LADFDKSIKWAEDPQKIKR----------------------DLEALGLLVLYVVKKGDIS 520 Query: 217 FEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVA--DPAKRISIPEIRNH 274 FE + ++F + I PD E R LI +F + R+S + H Sbjct: 521 FETLKN-QSFEEVIQ-------GSPD-----EETRDLIHHLFHPGDNVEDRLSS--LLAH 565 Query: 275 EWF 277 +F Sbjct: 566 PFF 568 >6EAS-A nrPDB Length = 308 Score = 76.4 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 87/268 (32%), Gaps = 46/268 (17%) Query: 30 GNFGVARLMRDK-QSNELVAV--------KYIERGEKIDENVKREIINHRSLRHPNIVRF 80 G+ L + S +AV K + ++ + +++I N + H N + Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAK--DWSKENESQYRKKITNLSKVSHKNFMNL 106 Query: 81 KEVILTPTHL--AIVMEYASGGELFERIC--NAGRFSEDEARFFFQQLISGVSYCHAMQ- 135 +V EYA G LFE + A + + + + H +Q Sbjct: 107 LGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQT 166 Query: 136 -VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP--EVLLKKE 192 R+ L A K+ D + + H+ + +P E +++K Sbjct: 167 PAALRNFDSTTVYLTDDFAA--KVSDLEFWNDAKGHNSTTNNELA---FSPDMEDIVRK- 220 Query: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS----P 248 G+ L +L G P + + P + R + + + S P Sbjct: 221 ----------YGMVLLEILTGRVPSSEDDGP--LENWVSRYFEGGMRLEELIDPSIGFFP 268 Query: 249 E--CRHL---ISRIFVADPAKRISIPEI 271 E R L + DP KR + E+ Sbjct: 269 EDTARALCEVVRSCIDRDPKKRPQMKEV 296 >6EWX-A nrPDB Length = 484 Score = 75.6 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 44/199 (22%), Positives = 67/199 (33%), Gaps = 45/199 (22%) Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL------------------------- 148 E F QL +G+ + + HRDL LEN LL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 149 --------------DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 PRL I +F +K + + A +APE++ +Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 + D + G+ +Y +L PF E + + +P SP + L Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF----EVRAQLRERDYRREDLPPLPTLSLYSPGLQQLA 382 Query: 255 SRIFVADPAKRISIPEIRN 273 + ADP KRI I E + Sbjct: 383 HLLLEADPIKRIRIGEAKR 401 >4CI6-B nrPDB Length = 643 Score = 71.4 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 95/265 (35%), Gaps = 39/265 (14%) Query: 41 KQSNELVAVKYIERGEKIDENVKREIINHRSL-----RHPNIVRFKEV----ILTPTHLA 91 K LVA IER + ++ E+ ++ + +HPN+ + + A Sbjct: 66 KDKQRLVA--KIERS-IAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 92 IVMEYASG-------GELFERICNAGRFSED---EARFFFQQLISGVSYCHAMQVCHRDL 141 ++M+ G L + SE +F +L+ ++ + H D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVW 201 K N + D + + + D G S QPK T ++ APE+ + + +DV+ Sbjct: 183 KPGNVVFDRASGEPV-VIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF 237 Query: 202 SCGVTLYVMLVGAYPFEDPEEPKNFR-------KTIHRILNVQYAI--PDYVHISPECRH 252 + + +L G FE E K + + H + Y I P + Sbjct: 238 ---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTR 294 Query: 253 LISRIFVADPAKRISIPEIRNHEWF 277 I+ I R E R HE+ Sbjct: 295 FITDILGVSADSRPDSNEARLHEFL 319 >5VE6-A nrPDB Length = 492 Score = 70.2 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 44/209 (21%), Positives = 67/209 (32%), Gaps = 55/209 (26%) Query: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL------------------------- 148 E F QL +G+ + + HRDL LEN LL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPP 266 Query: 149 ------------------------DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 184 PRL I +F +K + + A +A Sbjct: 267 CSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLA 326 Query: 185 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV 244 PE++ +Y + D + G+ +Y +L PF E + + +P Sbjct: 327 PEIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQLRERDYRQEDLPPLPALS 380 Query: 245 HISPECRHLISRIFVADPAKRISIPEIRN 273 SP + L + ADP KRI I E + Sbjct: 381 LYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4OAU-C nrPDB Length = 699 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 83/243 (34%), Gaps = 51/243 (20%) Query: 44 NELVAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVILTPTHLAIVMEYAS--GG 100 + VAVK G +RE+ +S R + ++V F HL + + Sbjct: 366 KQEVAVKTFCEGSP---RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 422 Query: 101 ELFERICNAGRFSEDE--ARFFFQQLISGVSYCH-AMQVCHRDLKLENTLLDGSPAPRLK 157 + +E++ AR + V H + H+DL+ +N L+D A Sbjct: 423 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH-- 480 Query: 158 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCG-VTLYVMLVGAYP 216 + DF S Q D+ G + LYV+ G+ Sbjct: 481 LADFDKSIKWAGDPQEVKR----------------------DLEDLGRLVLYVVKKGSIS 518 Query: 217 FEDPEEPKNFRKTIHRILNVQYAIPDYVHISP--ECRHLISRIFVADPAKRISIPEIRNH 274 FED + N + V +SP E + LI R+F R + ++ H Sbjct: 519 FEDLKAQSN---------------EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGH 563 Query: 275 EWF 277 +F Sbjct: 564 PFF 566 >6BHC-A nrPDB Length = 438 Score = 69.5 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 94/269 (34%), Gaps = 50/269 (18%) Query: 47 VAVKYIERGEKIDENVKREIINHRSLR-HPNIVRFKEVILTP----------------TH 89 AVK + K + + +SL H NI + L +H Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 90 LAIVMEYASGGELFERIC-------NAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 + ++ + + + + E + QL SG+ + V H DL+ Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLR 205 Query: 143 LENTLL-------------------DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 183 LEN LL S RL + +F +K P+ + Sbjct: 206 LENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR-L 264 Query: 184 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDY 243 APE++ +Y K D + G+ +Y ML PF++ E K T + + + P Sbjct: 265 APEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSP-- 320 Query: 244 VHISPECRHLISRIFVADPAKRISIPEIR 272 S + L S + +P++RI I + + Sbjct: 321 --YSRGLQQLASCLLNPNPSERILISDAK 347 >2JII-A nrPDB Length = 352 Score = 63.3 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 22/168 (13%), Positives = 58/168 (34%), Gaps = 13/168 (7%) Query: 84 ILTPTHLAIVMEYASGGELFERI--CNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDL 141 + + +V+ G L + SE +L+ + + H + H ++ Sbjct: 127 VHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNV 185 Query: 142 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--------GTPAYIAPEVLLKKEY 193 EN +D ++ + +G++ + + V G +I+ ++ Sbjct: 186 TAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG- 244 Query: 194 DGKVADVWSCGVTLYVMLVGAYPFEDP-EEPKNFRKTIHRILNVQYAI 240 + +D+ S G + L G P+ + ++ K + ++ Sbjct: 245 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPF 292 >6M7Z-A nrPDB Length = 319 Score = 59.5 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 41/249 (16%), Positives = 86/249 (34%), Gaps = 44/249 (17%) Query: 64 REIINHRS-LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 REI+ RS L P++ ++ LT + S G + + + S + + Sbjct: 99 REILPKRSPLLLPSLGEYRGAFLTY-----IFHPLSKGLVGDMLETGR--SHPDVQVLAA 151 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 182 +++ + H + + HR ++L + + L G ++ + ++ + VG Sbjct: 152 NMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLG----GLDTAAPIGTETRLWVGFFGQ 207 Query: 183 -IAPEV--------LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI 233 APE+ L + +DV+S GV FR + + Sbjct: 208 ETAPEIDRNFLADLALTQGRHTVKSDVYSLGV-------------------AFRNLVQLL 248 Query: 234 LNVQYAIPDYVHISPECRHLI----SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDN 289 N D + + L+ ++ +P R +I EI F D+ Sbjct: 249 GNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGK 308 Query: 290 TMTTQFDES 298 ++ ++ Sbjct: 309 ARPFRYKQN 317 >5GZ9-A nrPDB Length = 305 Score = 55.6 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 39/116 (33%), Gaps = 11/116 (9%) Query: 24 VKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEV 83 +K +G G L K+ VA+ + R E E+ + +SL+ ++V Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEM-KEDFLHGLQMLKSLQSEHVVTLVGY 95 Query: 84 ILTPTHLAIVMEYASGGEL------FERICNAGRFSEDEARFFFQQLISGVSYCHA 133 I+ EY G L + + + +S ++Y H Sbjct: 96 CEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHH 149 >6G38-A nrPDB Length = 357 Score = 53.3 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 36/195 (18%), Positives = 62/195 (31%), Gaps = 52/195 (26%) Query: 1 MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE------- 53 M + GP+ +++ + + IG G FG + + VA+K I Sbjct: 23 MGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLV 80 Query: 54 --RGEKIDENVKREIINHRS-----------------LRHPNIVR-------FKEV---- 83 +K E + EII + L + V+ K Sbjct: 81 NGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYN 140 Query: 84 -----------ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCH 132 L IV+E+ GG E++ S A+ QL + ++ Sbjct: 141 STKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQM-RTKLSSLATAKSILHQLTASLAVAE 199 Query: 133 -AMQVCHRDLKLENT 146 +++ HRDL N Sbjct: 200 ASLRFEHRDLHWGNV 214 >4CYJ-A nrPDB Length = 438 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 28/170 (16%), Positives = 61/170 (35%), Gaps = 24/170 (14%) Query: 32 FGV---ARLMRDKQSNELVAVKYIERGEKIDEN-VKREIINHRSLRHPNIVRFKEVILT- 86 FG ++ ++ A++ +E +E + + + + +++ +IV EV T Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTR 124 Query: 87 ---PTHLAIVMEYASGGELF----------ERICNAGRFSEDEARFFFQQLISGVSYCHA 133 + L ++ + R E+ + Q+ + + H+ Sbjct: 125 EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 134 MQVCHRDLKLENTLLDGSPAPRLK---ICD---FGYSKSSVLHSQPKSTV 177 ++ R L+ +L RL I D FG + SV+ Q + V Sbjct: 185 NRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFV 234 >5GZA-A nrPDB Length = 290 Score = 52.5 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 38/118 (32%), Gaps = 11/118 (9%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFK 81 VK IG G L + VA+ + ++ ++ + R+L+ ++V Sbjct: 28 RRVKLIGQGAVKKVYLSE--WQGQKVALSVLS-SDQYADDFLHGLSMLRALQSSHVVTLV 84 Query: 82 EVILTPTHLAIVMEYASGGELFER------ICNAGRFSEDEARFFFQQLISGVSYCHA 133 V V EY G + R S ++ ++Y H+ Sbjct: 85 GVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 >4BWP-A nrPDB Length = 448 Score = 50.6 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 23/162 (14%), Positives = 42/162 (25%), Gaps = 37/162 (22%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILT----PTHLA 91 + ++ I + + L+H N+V+ +EV T L Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLV 126 Query: 92 IVMEYASGGELF-------------------------------ERICNAGRFSEDEARFF 120 +V +Y G + +R N E Sbjct: 127 LVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSI 186 Query: 121 FQQLISGVSYCHAMQVCHRDLKLENTLLDGSPA--PRLKICD 160 QL +G+ H + + L ++ G I D Sbjct: 187 IMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4AZW-A nrPDB Length = 471 Score = 49.8 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 43/139 (30%), Gaps = 20/139 (14%) Query: 32 FGVARLMR----DKQSNELVAVKYIERGEKIDENVKREIINHRS----LRHPNIVRFKEV 83 FG + + D L A E ++ + EI P ++ Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKHELHNEIKFLTQPPAGFDAPAVL---AH 310 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 +VME G L + + E + L+ ++ H D++ Sbjct: 311 GENAQSGWLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKKGFWHDDVRP 367 Query: 144 ENTLLDGSPAPRLKICDFG 162 N ++D R + DFG Sbjct: 368 WNVMVDARQHAR--LIDFG 384 >4AZV-A nrPDB Length = 569 Score = 49.4 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 43/139 (30%), Gaps = 20/139 (14%) Query: 32 FGVARLMR----DKQSNELVAVKYIERGEKIDENVKREIINHRS----LRHPNIVRFKEV 83 FG + + D L A E ++ + EI P ++ Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKYELHNEIKFLTQPPAGFDAPAVL---AH 310 Query: 84 ILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 +VME G L + + E + L+ ++ H D++ Sbjct: 311 GENAQSGWLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKQGFWHDDVRP 367 Query: 144 ENTLLDGSPAPRLKICDFG 162 N ++D R + DFG Sbjct: 368 WNVMVDARQHAR--LIDFG 384 >3BYV-A nrPDB Length = 377 Score = 49.1 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 22/184 (11%), Positives = 49/184 (26%), Gaps = 25/184 (13%) Query: 102 LFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDF 161 L Q+I ++ H + H L+ + +LD + + F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGF 250 Query: 162 GYSKSSVLHSQPKSTVGTPAYIAPEVLLKK---EYD-------GKVADVWSCGVTLYVML 211 + V + + + PE+ ++ Y D W+ G+ +Y + Sbjct: 251 ---EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIW 307 Query: 212 VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEI 271 P + ++ +I R L+ R+ + Sbjct: 308 CADLPITKDAA----------LGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQA 357 Query: 272 RNHE 275 Sbjct: 358 METP 361 >4CZY-B nrPDB Length = 429 Score = 48.3 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 18/120 (15%), Positives = 43/120 (35%), Gaps = 16/120 (13%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPNIVRFKEVILT----PTHL 90 ++ ++ A++ IE +E + + + + NIV E T + L Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSL 120 Query: 91 AIVMEYASGGE-LFER----------ICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 V ++ E L++ + N + E+ + Q+ + + H ++ R Sbjct: 121 IFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAAR 180 >2W1Z-A nrPDB Length = 368 Score = 48.3 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 45/320 (14%), Positives = 89/320 (27%), Gaps = 78/320 (24%) Query: 15 MHDSDRYELVKDIGS--------------GNFGVARLMRDKQSNE--LV----------- 47 + + + ++G G++ + D+++ E V Sbjct: 41 WRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPS 99 Query: 48 -AVKYIERGEKIDENVKREIINHRS-------------LRHPNIVRFKEVILTPTHLAIV 93 A+K + + + + R I N R ++ P + V L + ++ Sbjct: 100 NAIKQLSE-QVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVL 158 Query: 94 --------ME--YASGGE-LFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 M+ G+ L QLI + + H D + Sbjct: 159 SRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQ 218 Query: 143 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE-----VLLKKEYD--- 194 + N LLD L G+ + S +G + PE +L +++ Sbjct: 219 VRNILLDQRGGVFLT----GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTL 273 Query: 195 -GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHL 253 D W+ G+ +Y + P + E R N I R L Sbjct: 274 MTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKN----------IPQPVRAL 323 Query: 254 ISRIFVADPAKRISIPEIRN 273 + R+ + Sbjct: 324 LEGFLRYSKEDRLLPLQAME 343 >3ENH-A nrPDB Length = 540 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 34/135 (25%), Positives = 48/135 (35%), Gaps = 27/135 (20%) Query: 49 VKYIERGEKIDENVK-----REIINHRSLRH-----PNIVRFKEVILTPTHLAIVMEYAS 98 VK R E++DEN++ RE ++ P I +V L I+M Y + Sbjct: 368 VKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYI---FDVDLDNKR--IMMSYIN 422 Query: 99 GGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKI 158 G + I + ++ V H V H DL N + D L I Sbjct: 423 GKLAKDVIEDN--------LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD----LYI 470 Query: 159 CDFGYSKSSVLHSQP 173 DFG K S L Sbjct: 471 IDFGLGKISNLDEDK 485 >3DZO-A nrPDB Length = 413 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 35/261 (13%), Positives = 71/261 (27%), Gaps = 49/261 (18%) Query: 48 AVKYIERGEKIDENVKREIINHRS-------------LRHPNIVRFKEVILTPTHLAI-- 92 A+K ++ E + + R I N + ++ P + V L + + Sbjct: 121 AIKQMKE-EVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLS 179 Query: 93 -VMEYASGGE--------LFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKL 143 Y L Q+I ++ H + H L+ Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 239 Query: 144 ENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE-----VLLKKEYD---- 194 + +LD L G+ + S +G + PE +L ++ Sbjct: 240 VDIVLDQRGGVFLT----GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLM 294 Query: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 D W+ G+ +Y + P D + ++ +I R L+ Sbjct: 295 TFAFDTWTLGLAIYWIWCADLPNTDDAA----------LGGSEWIFRSCKNIPQPVRALL 344 Query: 255 SRIFVADPAKRISIPEIRNHE 275 R+ + Sbjct: 345 EGFLRYPKEDRLLPLQAMETP 365 >3Q60-A nrPDB Length = 371 Score = 42.1 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 55/164 (33%), Gaps = 8/164 (4%) Query: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 179 QLI + + + H +N + P RL + D S + ++ ++ Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFI--MPDGRLMLGD--VSALWKVGTRGPASSVP 254 Query: 180 PAYIAPEVLLKKEYD-GKVADVWSCGVTLYVMLVGAYPFE--DPEEPKNFRKTIHRILNV 236 Y E L + W G+++Y + PF P ++++ R+ Sbjct: 255 VTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGT 314 Query: 237 Q-YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 A + + LI R D +R+ E FL+ Sbjct: 315 DSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >6FBK-A nrPDB Length = 98 Score = 40.2 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 8/68 (11%), Positives = 26/68 (38%), Gaps = 1/68 (1%) Query: 284 DLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDL 343 + D + + E D +S +++ E G N + + D++ + +++ Sbjct: 1 SMAEDTGVRVELAEEDHGRKSTIA-LRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEV 59 Query: 344 ESDLDDLD 351 ++ + Sbjct: 60 AQEMIESG 67 >4WWA-A nrPDB Length = 261 Score = 39.4 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 46/152 (30%), Gaps = 28/152 (18%) Query: 36 RLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIV------------RFKEV 83 L R K S++ +KY + + + HR+L ++ + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 84 ILTPTHLAIVM--EYASGGELFERICN---------AGRFSEDEARFFFQQLISGVSYCH 132 + + E GG F + N R +Q+ G+ H Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL--LH 153 Query: 133 AMQVCHRDLKLENTLLDGSPAP-RLKICDFGY 163 CH DL N +L A + DFG Sbjct: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >1TQM-A nrPDB Length = 282 Score = 38.3 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 47/159 (29%), Gaps = 36/159 (22%) Query: 23 LVKDIGSGN-----------FGVARLMRDKQSNELVAVKYIERGEKID---------ENV 62 + K +G G FG + K + K ++ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSA 151 Query: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 + E + L+ + + A++ME EL+ R + Sbjct: 152 RNEFRALQKLQGLAVPKVYAW----EGNAVLMELIDAKELY-------RVRVENPDEVLD 200 Query: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDF 161 ++ V+ + + H DL N L+ + I DF Sbjct: 201 MILEEVAKFYHRGIVHGDLSQYNVLVSEEG---IWIIDF 236 >2LRU-A nrPDB Length = 98 Score = 37.9 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 25/56 (44%), Gaps = 2/56 (3%) Query: 296 DESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLD 351 +E D +I+ ++I E G N + S D++ D+ ED+ ++ + Sbjct: 17 EEDDGEKIAIKLWLRI--EDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESG 70 >4BVU-A nrPDB Length = 211 Score = 35.2 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 44/149 (29%), Gaps = 29/149 (19%) Query: 23 LVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKE 82 L K IG G+ + S + + + N EI+ Sbjct: 44 LGKLIGQGSTAEIFEDVNDSS-------ALYKKYDLIGNQYNEILEMAWQESE----LFN 92 Query: 83 VILTPTHLAIVMEYASGGELFERICNAGRFSEDEA----------RFFFQQLISGVSYCH 132 ++V++Y GG+++ R+ + + Q + + Sbjct: 93 AFY-GDEASVVIQY--GGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LN 145 Query: 133 AMQVCHRDLKLENTLLDGSPAPRLKICDF 161 + + H DL N L D I DF Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPI-DF 173 >4H05-A nrPDB Length = 273 Score = 32.9 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 20/57 (35%), Gaps = 5/57 (8%) Query: 136 VCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP-----AYIAPEV 187 VCH DL +N LLD + D G + HS + + PE Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPEC 242 >5YK0-A nrPDB Length = 452 Score = 32.1 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 44/178 (24%), Gaps = 60/178 (33%) Query: 33 GVARLMRDKQSNELVAVKYIERGEK-----IDENVKREIINHRSL--------------- 72 G VAVK G + ++R + + L Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 73 -----------------------RHP-----NIVRFKEVILTPTHLAIVMEYASGGELFE 104 HP ++V ++ E+ G + E Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVV-------ASAPKVVIQEWIEGVPMAE 257 Query: 105 RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFG 162 I + D +L + + H D N +L P R+ I DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFML--LPDGRMGIIDFG 311 >6G5I-z nrPDB Length = 568 Score = 32.1 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 54/165 (32%), Gaps = 30/165 (18%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH------- 74 E+ I +G + E A+K + + ++ + + RH Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNP 239 Query: 75 ------------PNIVRFKEV---ILTPTHL---AIVMEYASGGELFERICNAGRFSEDE 116 N++R P L +VM + ++ + + SE + Sbjct: 240 RKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESK 299 Query: 117 ARFFFQQLISGVSYCHA-MQVCHRDLKLENTLLDGSPAPRLKICD 160 AR + Q+I + + ++ H DL N L G + I D Sbjct: 300 ARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHG---GGVYIID 341 >4OTP-A nrPDB Length = 352 Score = 32.1 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 54/165 (32%), Gaps = 30/165 (18%) Query: 22 ELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRH------- 74 E+ I +G + E A+K + + ++ + + RH Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNP 97 Query: 75 ------------PNIVRFKEV---ILTPTHL---AIVMEYASGGELFERICNAGRFSEDE 116 N++R P L +VM + ++ + + SE + Sbjct: 98 RKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESK 157 Query: 117 ARFFFQQLISGVSYCHA-MQVCHRDLKLENTLLDGSPAPRLKICD 160 AR + Q+I + + ++ H DL N L G + I D Sbjct: 158 ARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHG---GGVYIID 199 >6EF6-A nrPDB Length = 354 Score = 31.7 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%), Gaps = 1/28 (3%) Query: 135 QVCHRDLKLENTLLDGS-PAPRLKICDF 161 + H DL+L N L+D S P + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6G18-v nrPDB Length = 552 Score = 30.2 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 28/78 (35%), Gaps = 10/78 (12%) Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSE-DEARFFFQQLISGVSYCHAMQVCHRDLKL 143 + A+VME +G L + S DEA +L + H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 144 ENTLLDGSPAPRLKICDF 161 N +LD S + + DF Sbjct: 232 FNLILDESD--HITMIDF 247 >4GYG-A nrPDB Length = 397 Score = 29.8 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 24/78 (30%), Gaps = 14/78 (17%) Query: 92 IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL--- 148 IVM L + + S + + LI+ + + H D N L+ Sbjct: 188 IVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREE 241 Query: 149 -DGSPAPRLK----ICDF 161 D + I DF Sbjct: 242 KDAEDPSSITLTPIIIDF 259 >6FDN-A nrPDB Length = 320 Score = 29.0 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 27/77 (35%), Gaps = 8/77 (10%) Query: 85 LTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLE 144 + A+VME +G L ++ + + + + + H D Sbjct: 179 IDYNRHAVVMELINGYPL------CQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEF 232 Query: 145 NTLLDGSPAPRLKICDF 161 N +LD S + + DF Sbjct: 233 NLILDESD--HITMIDF 247 >2X8T-A nrPDB Length = 471 Score = 29.0 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 14/43 (32%) Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSED 115 +HPN+V L +V SGG + F Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLP 207 >3LV4-A nrPDB Length = 456 Score = 29.0 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 14/43 (32%) Query: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSED 115 +HPN+V L +V SGG + F Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFPLP 184 >3L2C-A nrPDB Length = 110 Score = 29.0 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 20/31 (64%), Gaps = 2/31 (6%) Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 LIS+ + P KR+++ +I +EW ++ +P Sbjct: 31 ELISQAIESAPEKRLTLAQI--YEWMVRTVP 59 >1E17-A nrPDB Length = 150 Score = 29.0 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 20/31 (64%), Gaps = 2/31 (6%) Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 LIS+ + P KR+++ +I +EW ++ +P Sbjct: 47 ELISQAIESAPEKRLTLAQI--YEWMVRTVP 75 >2UZK-A nrPDB Length = 97 Score = 28.6 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 20/31 (64%), Gaps = 2/31 (6%) Query: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 LI+R + P KR+++ +I +EW ++ +P Sbjct: 8 DLITRAIESSPDKRLTLSQI--YEWMVRCVP 36 >6FAI-l nrPDB Length = 425 Score = 28.3 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 28/182 (15%), Positives = 52/182 (28%), Gaps = 40/182 (21%) Query: 10 MDLPIMHDSD-RYELVKDIGSGNFGVARLMRDKQSNELVAVKY----------------- 51 + L M + D Y + IG G + DK N V +K Sbjct: 83 LALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDY 141 Query: 52 IERGEK-------IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFE 104 +++ + +E L + E H+ +VME G + Sbjct: 142 LKKSNQGANWMHLSRLAANKEYQFMSMLYSKG-FKVPEPFDNSRHI-VVMELIEGYPMR- 198 Query: 105 RICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLL-----DGSPAPRLKIC 159 R+ + L+ + + H D N ++ D + + + Sbjct: 199 RLRKHKNIP-----KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFV-VI 252 Query: 160 DF 161 DF Sbjct: 253 DF 254 >5GO1-A nrPDB Length = 151 Score = 28.3 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 28/63 (44%), Gaps = 5/63 (7%) Query: 33 GVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAI 92 G +++ +LVA+K ++ + E +++ + P +V++ + + + Sbjct: 21 GEVICRFERKGYKLVALKMLQPTTEQAEGHYKDLSSKPFF--PALVKY---FSSGPIVCM 75 Query: 93 VME 95 V E Sbjct: 76 VWE 78 >5IOL-A nrPDB Length = 150 Score = 27.9 bits (61), Expect = 7.5, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 26/63 (41%), Gaps = 5/63 (7%) Query: 33 GVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAI 92 G +++ +LVA+K + E++ ++ +SL + + + + + Sbjct: 20 GEVIQRFERRGYKLVAIKMMHASEQL---LQTHYEALKSLS--FFPKLVAYMSSGPVVPM 74 Query: 93 VME 95 V E Sbjct: 75 VFE 77 >3B6C-A nrPDB Length = 234 Score = 27.5 bits (60), Expect = 8.4, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 16/41 (39%) Query: 102 LFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLK 142 +F+ + E E + +Q+ M + HRDL Sbjct: 57 VFDIVLTEVEVPEPEPGRWAEQVKEMCRSLRRMFLAHRDLA 97 >1XIQ-A nrPDB Length = 157 Score = 27.5 bits (60), Expect = 9.5, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 30/63 (47%), Gaps = 5/63 (7%) Query: 33 GVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAI 92 G +K+ +L+A+K + E+I + +E+ + + N+V + I +A+ Sbjct: 27 GTIIKRFEKKGYKLIAIKMLNPTEEILKEHYKELSDQPFFK--NLVAY---ISKGPVVAM 81 Query: 93 VME 95 V E Sbjct: 82 VWE 84 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.157 0.478 Lambda K H 0.267 0.0478 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,387,941 Number of Sequences: 36641 Number of extensions: 746393 Number of successful extensions: 6636 Number of sequences better than 10.0: 517 Number of HSP's better than 10.0 without gapping: 812 Number of HSP's successfully gapped in prelim test: 152 Number of HSP's that attempted gapping in prelim test: 2266 Number of HSP's gapped (non-prelim): 1091 length of query: 362 length of database: 10,336,785 effective HSP length: 98 effective length of query: 264 effective length of database: 6,745,967 effective search space: 1780935288 effective search space used: 1780935288 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.5 bits)