BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q93WX6 (463 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4Q75-A nrPDB 882 0.0 1T3I-A nrPDB 536 e-153 5XT5-A nrPDB 437 e-123 4W91-A nrPDB 382 e-106 6MRE-A nrPDB 379 e-105 5VPR-A nrPDB 368 e-102 6C9E-A nrPDB 344 5e-95 4LW2-A nrPDB 313 8e-86 5WT2-A nrPDB 103 1e-22 4EB7-A nrPDB 103 2e-22 1ECX-A nrPDB 96 4e-20 5WGB-A nrPDB 95 7e-20 3CAI-A nrPDB 89 4e-18 3LVM-A nrPDB 85 7e-17 4ISY-A nrPDB 80 3e-15 3A9Z-A nrPDB 66 3e-11 3GZD-A nrPDB 62 5e-10 5HH9-A nrPDB 57 2e-08 3OP7-A nrPDB 52 5e-07 1QZ9-A nrPDB 42 5e-04 1M32-A nrPDB 41 0.001 3QI6-A nrPDB 40 0.003 4BMK-A nrPDB 38 0.009 1GC4-A nrPDB 38 0.011 1CS1-A nrPDB 36 0.030 6HRH-B nrPDB 36 0.046 1XI9-A nrPDB 35 0.100 3VK2-A nrPDB 34 0.16 5V1X-E nrPDB 34 0.17 3MKJ-A nrPDB 34 0.17 3AEO-A nrPDB 33 0.22 3WKR-A nrPDB 33 0.28 3MAF-B nrPDB 33 0.30 2CB1-A nrPDB 33 0.33 3BB8-A nrPDB 32 0.40 4J8L-A nrPDB 32 0.46 1IBJ-A nrPDB 32 0.48 1YIY-A nrPDB 32 0.53 2E7J-A nrPDB 31 1.2 2X8U-A nrPDB 30 1.5 5K0Z-A nrPDB 30 1.8 4KAM-A nrPDB 30 1.8 3RI6-A nrPDB 30 2.8 2Z9W-A nrPDB 29 4.8 4L0O-H nrPDB 29 4.9 3DR4-A nrPDB 29 5.0 1VJO-A nrPDB 28 5.8 6EOT-A nrPDB 28 7.6 5TSU-A nrPDB 28 7.6 1J32-A nrPDB 28 8.7 4CVQ-A nrPDB 28 9.3 >4Q75-A nrPDB Length = 429 Score = 882 bits (2279), Expect = 0.0, Method: Compositional matrix adjust. Identities = 428/428 (100%), Positives = 428/428 (100%) Query: 36 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY 95 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY Sbjct: 2 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY 61 Query: 96 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG 155 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG Sbjct: 62 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG 121 Query: 156 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 215 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK Sbjct: 122 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 181 Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK 275 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK Sbjct: 182 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK 241 Query: 276 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL 335 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL Sbjct: 242 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL 301 Query: 336 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL 395 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL Sbjct: 302 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL 361 Query: 396 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 455 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT Sbjct: 362 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 421 Query: 456 VSFFNSFK 463 VSFFNSFK Sbjct: 422 VSFFNSFK 429 >1T3I-A nrPDB Length = 420 Score = 536 bits (1382), Expect = e-153, Method: Compositional matrix adjust. Identities = 258/409 (63%), Positives = 310/409 (75%), Gaps = 2/409 (0%) Query: 52 SLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLS 111 SL VR+DF IL+QE+NG LVYLD+AATSQKP AVL+ L +YYE N+NVHRG H LS Sbjct: 8 SLAATVRQDFPILNQEINGHPLVYLDNAATSQKPRAVLEKLMHYYENDNANVHRGAHQLS 67 Query: 112 AKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAE 171 +ATD +E R KVA+FINA REIV+TRNATEAINLVAYSWG++NLK GDE+I TV E Sbjct: 68 VRATDAYEAVRNKVAKFINARSPREIVYTRNATEAINLVAYSWGMNNLKAGDEIITTVME 127 Query: 172 HHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP 231 HHS +VPWQ+V+ KTGAVLKFV L+E E D+ + L+S KTKLV V H+SN L P Sbjct: 128 HHSNLVPWQMVAAKTGAVLKFVQLDEQESFDLEHFKTLLSEKTKLVTVVHISNTLGCVNP 187 Query: 232 IEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDL 291 EEI AH GAKVLVDACQS PH +DVQ ++ D+LVAS HKMC PTGIGFLYGK ++ Sbjct: 188 AEEIAQLAHQAGAKVLVDACQSAPHYPLDVQLIDCDWLVASGHKMCAPTGIGFLYGKEEI 247 Query: 292 LHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIH 351 L +MPPF GGGEMI++VF DH T E P +FEAGTPAI EAIALGAAVDYL+ +GM IH Sbjct: 248 LEAMPPFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAVDYLTDLGMENIH 307 Query: 352 EYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVA 411 YEVE+ YL++ L +P +R+YGP P R AL SFNV GLH +D+AT +DQ G+A Sbjct: 308 NYEVELTHYLWQGLGQIPQLRLYGPNPKHG-DRAALASFNVAGLHASDVATMVDQD-GIA 365 Query: 412 IRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFN 460 IRSGHHC QPLHR + SARASLYFYNTK+++D F+ +L T+ FF+ Sbjct: 366 IRSGHHCTQPLHRLFDASGSARASLYFYNTKEEIDLFLQSLQATIRFFS 414 >5XT5-A nrPDB Length = 419 Score = 437 bits (1123), Expect = e-123, Method: Compositional matrix adjust. Identities = 210/405 (51%), Positives = 278/405 (68%), Gaps = 6/405 (1%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R+ F ILHQ+VNG LVYLDSAATSQKP AV++ L YY YNSNVHRG+H L +ATD Sbjct: 9 IREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATD 68 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 +E AR+KV +FINA EI+FT+ T ++N+VA S+ +NLKPGDEV++T EHH+ I Sbjct: 69 GYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVITYMEHHANI 128 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 +PWQ + TGA LK++ L ED + +RE ++ TK+VAV HVSNVL + PI+E+ Sbjct: 129 IPWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMA 188 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMP 296 AHD GA ++VD QS PHM +DVQ L+ DF SSHKMCGPTG+G LYGK LL +M Sbjct: 189 KIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENME 248 Query: 297 PFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVE 356 P GGEMI V L ST+ E P +FEAGTP I AI LGAA+D+L IG+ +I +E + Sbjct: 249 PAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEISRHEHK 308 Query: 357 IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGH 416 + Y E+ L V +YGP R L +FN++ +HP D+AT LD + G+A+R+GH Sbjct: 309 LAAYALERFRQLDGVTVYGPE-----ERAGLVTFNLDDVHPHDVATVLDAE-GIAVRAGH 362 Query: 417 HCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 HCAQPL ++L V A+ARAS Y YNT++++D + AL T +F + Sbjct: 363 HCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTKEYFTN 407 >4W91-A nrPDB Length = 422 Score = 382 bits (980), Expect = e-106, Method: Compositional matrix adjust. Identities = 188/403 (46%), Positives = 270/403 (66%), Gaps = 5/403 (1%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R+DF IL ++V+G LVYLD+ A++QKP +V+DA+ + Y +NVHRG+H+LS ATD Sbjct: 24 IRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATD 83 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 +E +R+ V RF+NA EIVFT+NATEAIN VAY +G+ + GDE++L++ EHHS I Sbjct: 84 AYEKSRETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNI 143 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 VPW + ++ GA L F ++++ V I + + +S +TKLVA+ H+SN L + +PI++IV Sbjct: 144 VPWHFIRERQGAKLVFTPVDDNGVFHIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIV 203 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMP 296 AH G VLVD Q H+ VDVQ L D+ V + HK+ GP+GIG LYG++ +L M Sbjct: 204 ELAHARGIPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSGIGVLYGRAQMLEKMR 263 Query: 297 PFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVE 356 PF GGGEMI +V ++ TY PP RFEAGTP I +AI LGAA++Y+ IG I +E + Sbjct: 264 PFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEAD 323 Query: 357 IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGH 416 + Y +E+L + +RI+G P +GA+ SF +EG+H D++ +D+ GVA+R+G Sbjct: 324 LRDYAHERLGRINSLRIFGNAPD----KGAIISFALEGIHAHDVSMVIDRA-GVAVRAGT 378 Query: 417 HCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 HCAQPL + GV ++ RAS YNT+ +VDA AL FF Sbjct: 379 HCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKARKFF 421 >6MRE-A nrPDB Length = 420 Score = 379 bits (974), Expect = e-105, Method: Compositional matrix adjust. Identities = 192/398 (48%), Positives = 260/398 (65%), Gaps = 7/398 (1%) Query: 56 RVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKAT 115 +VR DF +L +EVNG L YLDSAA++QKP+ V+DA +Y + VHRGIH LSA+AT Sbjct: 21 KVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQAT 80 Query: 116 DEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSC 175 ++ E RK+ + FINA + E+VF TE INLVA SWG SN++ GD +I++ EHH+ Sbjct: 81 EKMENVRKRASLFINARSAEELVFVAGTTEGINLVANSWGNSNVRAGDNIIISQMEHHAN 140 Query: 176 IVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI 235 IVPWQ++ + GA L+ + LN D + L L KT+L+A+ HVSNVL + P+ E+ Sbjct: 141 IVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEM 200 Query: 236 VVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSM 295 + AH GAKVLVD Q+V H VDVQ L+ DF V S HK+ GPTGIG LY K LL M Sbjct: 201 ITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEM 260 Query: 296 PPFLGGGEMISDVFL-DHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYE 354 PP+ GGG MI+ V L + +T+ + P RFEAGTP G I LGAA++Y+S +G+ I EYE Sbjct: 261 PPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYE 320 Query: 355 VEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRS 414 + Y +L S+PD+ +YGP+ +R + +FN+ H D+ +FLD +G+A+R+ Sbjct: 321 QNLMHYALSQLESVPDLTLYGPQ-----NRLGVIAFNLGKHHAYDVGSFLD-NYGIAVRT 374 Query: 415 GHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVAL 452 GHHCA PL Y V A RASL YNT ++VD + L Sbjct: 375 GHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGL 412 >5VPR-A nrPDB Length = 414 Score = 368 bits (945), Expect = e-102, Method: Compositional matrix adjust. Identities = 190/398 (47%), Positives = 256/398 (64%), Gaps = 16/398 (4%) Query: 55 HRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKA 114 +R F IL ++VNG LVYLD+AATSQKP VLDA+ NYYE YN+NVHRGIH LS A Sbjct: 13 QEIRSQFPILQEKVNGKDLVYLDNAATSQKPKMVLDAINNYYEHYNANVHRGIHTLSQVA 72 Query: 115 TDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNL-KPGDEVILTVAEHH 173 T+ E ARKKV RFINA E++FT+ TE INLVAY+ +++L K DE+I++ EHH Sbjct: 73 TEMMEDARKKVQRFINAKHDYEVLFTKGTTEGINLVAYA--MTDLIKKDDEIIISYLEHH 130 Query: 174 SCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIE 233 S IVPWQ++ Q+TGA L+ + +NED I+ L E +S KTKLV+V+ VSN L PI+ Sbjct: 131 SNIVPWQMLCQRTGAKLRVIPMNEDGTLQIDVLDEWLSEKTKLVSVNQVSNALGIVNPID 190 Query: 234 EIVVWAHDVGAK----VLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKS 289 EI+ V AK + +D Q+ PH +DVQ ++ DF S HKM GPTG G LYGK+ Sbjct: 191 EII---RKVRAKSNAFIFIDGAQAAPHFEIDVQTMDCDFFAFSGHKMYGPTGTGILYGKA 247 Query: 290 DLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPK 349 +L + PF GGGEMI + +TYA P RFEAGTP I IA+G AVD++ +G Sbjct: 248 SVLEQLNPFHGGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAIGTAVDFMEKVGRSN 307 Query: 350 IHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLH-PTDLATFLDQQH 408 I +E + +Y KL + +++YG E +R + SFN+ G+ +D+ LD+ Sbjct: 308 IAAHEHALLEYAQRKLLEIEGLKVYG----EKANRAGVVSFNLSGIGIASDVGMILDKL- 362 Query: 409 GVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVD 446 G+A+R+GHHC QP+ Y GV + RAS YNT +++D Sbjct: 363 GIAVRTGHHCTQPIMEYFGVAGTVRASFAVYNTFEEID 400 >6C9E-A nrPDB Length = 422 Score = 344 bits (882), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 182/407 (44%), Positives = 262/407 (64%), Gaps = 9/407 (2%) Query: 55 HRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKA 114 +++RKDF +LHQ++N LVY D+AAT+QKP AV+DA+ +YE NSNVHRG+H LS +A Sbjct: 22 NKIRKDFPVLHQKINEYDLVYFDNAATTQKPKAVIDAIAQFYEKDNSNVHRGVHALSVRA 81 Query: 115 TDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHS 174 T+ +E AR KV RFINA RE +F R TEAINLVA S + P +E+++T EHHS Sbjct: 82 TEMYEAARAKVKRFINARSPRECIFVRGTTEAINLVAQSLVAPRILPDEEILITHMEHHS 141 Query: 175 CIVPWQIVSQKTGAVLKF--VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPI 232 IVPWQ+V +K G L+ ++LN + + + + ++ TK+VA+++ SN L + P+ Sbjct: 142 NIVPWQMVCKKMGCKLQVAPISLNGEVI--LEEFERKLNENTKMVAINYASNSLGTINPV 199 Query: 233 EEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLL 292 + ++ AH+VGAKVL+D Q+ H++VDVQ L+ DF S HKM GPTGIG L+GK +LL Sbjct: 200 KTMIKMAHEVGAKVLLDGAQATAHLIVDVQDLDCDFYAFSGHKMYGPTGIGVLWGKEELL 259 Query: 293 HSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHE 352 +SM P+ GGGEMI+ V + + YA P +FEAGTP I AI L AA+DY+ + + I E Sbjct: 260 NSMTPYQGGGEMINSVSFEATEYAAIPHKFEAGTPNIAGAIGLAAAIDYIWSLDLDAIAE 319 Query: 353 YEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAI 412 YE ++ Y + + ++ I G + ++ + SF +H D+ T LD + G+AI Sbjct: 320 YETQLLNYATKAIEAVKGYNIIGT----AANKVPIISFVHGKIHAHDIGTILDSE-GIAI 374 Query: 413 RSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 RSGHHC PL + V A++R S+ FYNT ++D + AL F Sbjct: 375 RSGHHCTMPLMDFYDVAATSRISMSFYNTFKEIDYCMEALQRVKEVF 421 >4LW2-A nrPDB Length = 404 Score = 313 bits (803), Expect = 8e-86, Method: Compositional matrix adjust. Identities = 159/379 (41%), Positives = 237/379 (62%), Gaps = 7/379 (1%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 VYLDSAAT+ KP AV++A Q +Y NVHR + + T +E AR+KVA+ +NA D Sbjct: 24 VYLDSAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPD 83 Query: 134 SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFV 193 + IV+TR TE+IN+VA + L+PGDE+I++VAEHH+ +VPW +V+Q+TGA + + Sbjct: 84 DKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHANLVPWLMVAQQTGAKVVKL 143 Query: 194 TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQS 253 LN +PD++ L ELI+P+++++A+ +SNV + + +AH G V+VD Q Sbjct: 144 PLNAQRLPDVDLLPELITPRSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQG 203 Query: 254 VPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHS 313 H DVQ+L+ DF S HK+ GPTGIG LYGKS+LL +M P+LGGG+M+ +V D Sbjct: 204 AVHFPADVQQLDIDFYAFSGHKLYGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFDGF 263 Query: 314 TYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRI 373 T P + EAGTP + I L AA+++L+ + + + + + L+ P R Sbjct: 264 TTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRS 323 Query: 374 YGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASAR 433 + R +S +L +F+ G+H +D+ T L ++G+A+R+G HCAQPL LGV + R Sbjct: 324 F--RCQDS----SLLAFDFAGVHHSDMVTLL-AEYGIALRAGQHCAQPLLAELGVTGTLR 376 Query: 434 ASLYFYNTKDDVDAFIVAL 452 AS YNTK DVDA + A+ Sbjct: 377 ASFAPYNTKSDVDALVNAV 395 >5WT2-A nrPDB Length = 401 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 113/394 (28%), Positives = 180/394 (45%), Gaps = 46/394 (11%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 +YLD+ AT++ V + + + + N +H + A K+ + INA D Sbjct: 5 IYLDNNATTRIDPKVKEIMDPFLRDHYGN-PSSLHQFGTETHPAIAEALDKLYKGINARD 63 Query: 134 SREIVFTRNATEAINLVAYSWGLSN-LKPG-DEVILTVAEHHSCIVPWQIVSQKTGAVLK 191 +++ T ATE+ N V LK G + ++ TVAEH + + + G + Sbjct: 64 IDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFL-ESLGVEVT 122 Query: 192 FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 ++ +NE ++RE I+ KT LV+V +N PIEEI + G DA Sbjct: 123 YLPINEHGSITAEQVREAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAV 182 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLD 311 Q++ + VDV K NADFL S+HK GP GIG LY +S + + P GGE ++ Sbjct: 183 QAIGKIPVDVLKANADFLSFSAHKFHGPKGIGGLYIRSGV--GLTPLFHGGEHMNG---R 237 Query: 312 HSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVE-IGKY---LYEKLSS 367 S P +GEA+ L AV++L +YE E +GK L E L Sbjct: 238 RSGTLNVPY-----IVGMGEAMKL--AVEHL---------DYEKEVVGKLRDKLEEALLK 281 Query: 368 LPDVRIYGPRPSESVHRGALCSF-NVEGLHPTDLATFLDQQHGVAIRSGHHC------AQ 420 +PDV + G R +HR + +V G+ + L++ + +A +G C A Sbjct: 282 IPDVMVVGDR----IHRVPNTTLVSVRGIEGEAMLWDLNRSN-IAASTGSACASEDLEAN 336 Query: 421 PLHRYLGVN-----ASARASLYFYNTKDDVDAFI 449 P+ +G + + R SL +NT+ ++D I Sbjct: 337 PVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTI 370 >4EB7-A nrPDB Length = 382 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/236 (32%), Positives = 125/236 (52%), Gaps = 15/236 (6%) Query: 73 LVYLDSAATSQKPA--AVLDALQNYY--EFYNSNVHRGIHYLSAKATDEFELARKKVARF 128 + Y D TS KP +L+A+ Y F N + +H KA + + AR+KVA+ Sbjct: 1 MAYFDY--TSAKPVDERILEAMLPYMTESFGNPS---SVHSYGFKAREAVQEAREKVAKL 55 Query: 129 INASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGA 188 +N +VFT ATEA NL + + N + G ++++ EH S I P + + QK G Sbjct: 56 VNGGGGT-VVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFL-QKQGF 113 Query: 189 VLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV-VWAHDVGAKVL 247 ++++ + + D++ + + + T LV+V H +N + + P+EEI V A A + Sbjct: 114 EVEYIPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVLAGK--AALH 171 Query: 248 VDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGE 303 +DA SV + VDV+K+ AD L SS+ + GP G+G L+ + + P LGGG+ Sbjct: 172 IDATASVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWIRKE-AKLQPVILGGGQ 226 >1ECX-A nrPDB Length = 384 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 107/403 (26%), Positives = 187/403 (46%), Gaps = 44/403 (10%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 VY D+ AT++ VL+ + +Y N + H + +A E AR+KVA+ + S Sbjct: 3 VYFDNNATTRVDDRVLEEMIVFYREKYGNPNSA-HGMGIEANLHMEKAREKVAKVLGVSP 61 Query: 134 SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFV 193 S EI FT ATE+IN + + + K +I T EH + + + +S K G +K+V Sbjct: 62 S-EIFFTSCATESINWILKTVAETFEKRKRTIITTPIEHKAVLETMKYLSMK-GFKVKYV 119 Query: 194 TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI--VVWAHDVGAKVLVDAC 251 ++ V + +L +L+ T LV++ +N + + P+E++ +V + V VDA Sbjct: 120 PVDSRGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVTRIVKKKNKETLVHVDAV 179 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFL-GGGEMISDVFL 310 Q++ + ++KL D+ S+HK GP G+G Y + + + P + GGG+ + L Sbjct: 180 QTIGKIPFSLEKLEVDYASFSAHKFHGPKGVGITYIRKGV--PIRPLIHGGGQ---ERGL 234 Query: 311 DHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPD 370 T P +G A A+ AV+ LS E + K + +S L + Sbjct: 235 RSGTQNVP--------GIVGAARAMEIAVEELS--------EAAKHMEKLRSKLVSGLMN 278 Query: 371 VRIYGPRPSE-SVHRGALCSF-NVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRY--- 425 + + P E S+ SF N+ G + L L +G+ + + C R Sbjct: 279 LGAHIITPLEISLPNTLSVSFPNIRG---STLQNLL-SGYGIYVSTSSACTSKDERLRHV 334 Query: 426 ---LGVN-----ASARASLYFYNTKDDVDAFIVALADTVSFFN 460 +GV+ + R SL YNT+++VD F+ + + +SF + Sbjct: 335 LDAMGVDRRIAQGAIRISLCKYNTEEEVDYFLKKIEEILSFLD 377 >5WGB-A nrPDB Length = 426 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 103/214 (48%), Gaps = 4/214 (1%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 +Y+D AT+ VLDA+ Y Y N H H ++ E AR++VA I A D Sbjct: 28 LYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGA-D 86 Query: 134 SREIVFTRNATEAINLVAYSWGLSNL-KPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 REI+FT ATE+ N+ G++ + + ++T H C++ + G + + Sbjct: 87 PREIIFTSGATESNNIAIK--GVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTY 144 Query: 193 VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQ 252 + + + + D+ +L I P T LV+V V+N + PI EI DA Q Sbjct: 145 LPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQ 204 Query: 253 SVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLY 286 +V + +DV + D + S HK+ GP G+G +Y Sbjct: 205 AVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIY 238 >3CAI-A nrPDB Length = 406 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 101/411 (24%), Positives = 175/411 (42%), Gaps = 43/411 (10%) Query: 62 RILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELA 121 R LH + G V+ D+ A P +V + + ++ G H + ++ + A Sbjct: 17 RGLHPSL-GDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTV-GAHPSARRSAAVLDAA 74 Query: 122 RKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQI 181 R+ VA +NA D +V + ++L+A + S G EVI++ + + I PW Sbjct: 75 REAVADLVNA-DPGGVVLGADRAVLLSLLAEA-SSSRAGLGYEVIVSRLDDEANIAPWLR 132 Query: 182 VSQKTGAVLKF--VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWA 239 + + GA +K+ V + E+P + LIS T+LVAV+ S L + + Sbjct: 133 AAHRYGAKVKWAEVDIETGELPTW-QWESLISKSTRLVAVNSASGTLGGVTDLRAMTKLV 191 Query: 240 HDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFL 299 HDVGA V+VD + P+ ++D+++ +AD + ++H GP ++ +++S Sbjct: 192 HDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAHAWGGPPIGAMVFRDPSVMNSFGS-- 249 Query: 300 GGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLS--------------GI 345 + + YA P+R E G G + A+++YL+ + Sbjct: 250 ----------VSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLAV 299 Query: 346 GMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLD 405 M Y + YL L SLP V + G RP + + SF V + + L Sbjct: 300 SMQSADAYLNRVFDYLMVSLRSLPLVMLIG-RPEAQI---PVVSFAVHKVPADRVVQRLA 355 Query: 406 QQHGVAIRSGHHCAQPLHRYLGVN---ASARASLYFYNTKDDVDAFIVALA 453 +AI + + LGVN + L Y+T +VD + ALA Sbjct: 356 DNGILAI---ANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVRALA 403 >3LVM-A nrPDB Length = 423 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 4/215 (1%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNS--NVHRGIHYLSAKATDEFELARKKVARFINA 131 +YLD +AT+ V + + + + N H +A + ++AR ++A + A Sbjct: 24 IYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGA 83 Query: 132 SDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLK 191 D REIVFT ATE+ NL K G +I + EH + + + + ++ G + Sbjct: 84 -DPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQL-EREGFEVT 141 Query: 192 FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 ++ + + D+ +L + T LV++ HV+N + I I G VDA Sbjct: 142 YLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDAT 201 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLY 286 QSV + +D+ +L D + S HK+ GP GIG LY Sbjct: 202 QSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALY 236 >4ISY-A nrPDB Length = 404 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 109/401 (27%), Positives = 166/401 (41%), Gaps = 52/401 (12%) Query: 75 YLDSAATS-QKPAAV--LDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINA 131 YLD AAT+ PAA+ + A+Q +S +H A E AR+ +A + A Sbjct: 14 YLDHAATTPMHPAAIEAMAAVQRTIGNASS-----LHTSGRSARRRIEEARELIADKLGA 68 Query: 132 SDSREIVFTRNATEAINLVAYS--WGLSNLKPGDEVILTV-AEHHSCIVPWQIVSQKTGA 188 S E++FT TE+ NL W + +P I+T EHH+ + + + GA Sbjct: 69 RPS-EVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGA 127 Query: 189 VLKFVTLNEDEVPDINKLRELISP--KTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKV 246 + ++ D LRE + LV+V +N + + LPI E+ V A + G + Sbjct: 128 HVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPM 187 Query: 247 LVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMIS 306 DA Q+V + +D + + HK GP G+G L + D+ + P + GG Sbjct: 188 HSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDV--TCVPLMHGGGQER 245 Query: 307 DVFLDHSTYAEPPSRFEAGTP----AIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLY 362 D+ +GTP A+G A A AVD L + + L Sbjct: 246 DI--------------RSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLA 291 Query: 363 EKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHC---- 418 E + DV + G + + F G L LD +G+ +G C Sbjct: 292 E----IDDVCLNG--ADDPMRLAGNAHFTFRGCEGDALLMLLD-ANGIECSTGSACTAGV 344 Query: 419 AQPLHRY--LGVN-ASARASLYF----YNTKDDVDAFIVAL 452 AQP H +GV+ ASAR SL + + DVDA + L Sbjct: 345 AQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVL 385 >3A9Z-A nrPDB Length = 432 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 92/358 (25%), Positives = 141/358 (39%), Gaps = 56/358 (15%) Query: 71 SKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN 130 ++ VY+D AT+ V+ A+ + N + KA D AR +A+ I Sbjct: 17 NRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMIG 75 Query: 131 ASDSREIVFTRNATEAINLVAYS-------------WGLSNLKPGDEV----ILTVAEHH 173 ++I+FT TE+ NLV +S + + P + I EH Sbjct: 76 GK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHD 134 Query: 174 SCIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAVHHVSNVLASSLPI 232 S +P + + + A + FV +++ + ++ + + P T LV + +N +PI Sbjct: 135 SIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPI 194 Query: 233 EEI--------VVWAHDVGAKVLV--DACQSVPHMVVDVQKLNADFLVASSHKMCGPTGI 282 EI + A +VLV DA Q++ VDV+ L DFL HK GP I Sbjct: 195 SEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-I 253 Query: 283 GFLY--GKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVD 340 G LY G L P GGG+ F GT LG A D Sbjct: 254 GALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAAD 298 Query: 341 YLSGIGMPKIHEYEV---EIGKYLYEKLSSLPDVRIYGPRPSESVHR-GALCSFNVEG 394 +S YE +I YL E+L + RI+ V R C+F+++G Sbjct: 299 LVS----ENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQG 352 >3GZD-A nrPDB Length = 440 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 113/268 (42%), Gaps = 45/268 (16%) Query: 72 KLVYLDSAATSQKPAAVLDAL-QNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN 130 + VY+D AT+ V+ A+ + +E + + + KA D AR+ +A+ I Sbjct: 25 RKVYMDYNATTPLEPEVIQAMTKAMWEAWGNP--SSPYSAGRKAKDIINAARESLAKMIG 82 Query: 131 ASDSREIVFTRNATEAINLVAYSW-------------------GLSNLKPGDEVILTVAE 171 ++I+FT TE+ NLV +S + KP I + E Sbjct: 83 GK-PQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKP--HFITSSVE 139 Query: 172 HHSCIVPWQIVSQKTGAVLKFVTLN----EDEVPDINKLRELISPKTKLVAVHHVSNVLA 227 H S +P + + ++ A + FV ++ + EV DI + P T+LV + +N Sbjct: 140 HDSIRLPLEHLVEEQVAAVTFVPVSKVSGQTEVDDI---LAAVRPTTRLVTIMLANNETG 196 Query: 228 SSLPIEEI-----VVWAHDVGAK-----VLVDACQSVPHMVVDVQKLNADFLVASSHKMC 277 +P+ EI + V A V DA Q++ VDV+ L DFL HK Sbjct: 197 IVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFY 256 Query: 278 GPTGIGFLY--GKSDLLHSMPPFLGGGE 303 GP IG LY G + P GGG+ Sbjct: 257 GPR-IGALYIRGLGEFTPLYPMLFGGGQ 283 >5HH9-A nrPDB Length = 390 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/331 (21%), Positives = 132/331 (39%), Gaps = 42/331 (12%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNAT 144 P V +A++ ++ N + + + + AR R+ A ++ T + T Sbjct: 28 PRPVREAIERLRVRFDRNPGEAVDWHREEIWKYEDEARAWAGRYF-AVQPGQVALTGSTT 86 Query: 145 EAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTL-------NE 197 + + + +G ++PG E++ + EH+S + ++ G ++ L + Sbjct: 87 DGLAAI---YGGLLVQPGKEILTSSHEHYSTYTTLEYRHKRMGTQVREFPLFKDPHRVSA 143 Query: 198 DEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAK--------VLVD 249 DE+ ++ + I P+T+++ + V + LPI EI ++ K +VD Sbjct: 144 DEI--LSSIAAQIRPQTRVLGMTWVQSGSGVKLPIREIGKLVRELNQKRDEQDRIIYVVD 201 Query: 250 ACQSVPHMVVDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLLH-----SMPPFLGGGE 303 V + D+ +A +HK + GP G G + +S+ L S+P F Sbjct: 202 GVHGFGVEDVSFADFDCDYFIAGTHKWLFGPRGTGVIIARSEQLQEHLVPSIPTF----- 256 Query: 304 MISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYE 363 +D F T P G A +ALG A + +G ++ ++ YL + Sbjct: 257 SRADNF---GTLMTP-----GGYHAFEHRLALGTAFELHLQLGKAEVQARIHQLNAYLKQ 308 Query: 364 KLSSLPDVRIYGPRPSESVHRGALCSFNVEG 394 +L P VR+ P E F VEG Sbjct: 309 RLGEHPKVRLVTPTSPEL--SSGFTFFRVEG 337 >3OP7-A nrPDB Length = 375 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 67/133 (50%), Gaps = 13/133 (9%) Query: 122 RKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQI 181 +K V++ +I+ T AT A LV YS ++PGD VI + Sbjct: 69 KKSVSQLYTGVKPEQILQTNGATGANLLVLYSL----IEPGDHVISLYPTYQQLYD---- 120 Query: 182 VSQKTGAVLKFVTLNEDE--VPDINKLRELISPKTKLVAVHHVSNVLASSLP---IEEIV 236 + + GA + + E+ +PD+ KLR+LI P TK++ +++ +N + + +EE+V Sbjct: 121 IPKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICINNANNPTGAVMDRTYLEELV 180 Query: 237 VWAHDVGAKVLVD 249 A +VGA +L D Sbjct: 181 EIASEVGAYILSD 193 >1QZ9-A nrPDB Length = 416 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 81/342 (23%), Positives = 135/342 (39%), Gaps = 29/342 (8%) Query: 73 LVYLDSAATSQKPAAVLDALQNYY-EFYNSNVHRGIHYLSAKATDEFELARKKVARFINA 131 ++YLD + +P A L Q E + + + R + SA D E ++A I A Sbjct: 29 VIYLDGNSLGARPVAALARAQAVIAEEWGNGLIRS--WNSAGWRDLSERLGNRLATLIGA 86 Query: 132 SDSREIVFTRNATEAINLV-AYSWGL---SNLKPGDEVILTVAEHHSCIVPWQIVSQKTG 187 D E+V T T +INL S L + P VI+T E + I Sbjct: 87 RDG-EVVVTD--TTSINLFKVLSAALRVQATRSPERRVIVT--ETSNFPTDLYIAEGLAD 141 Query: 188 AVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVL 247 + + TL + P+ +L + I T +V + HV+ ++ + +H+ GA + Sbjct: 142 MLQQGYTLRLVDSPE--ELPQAIDQDTAVVMLTHVNYKTGYMHDMQALTALSHECGALAI 199 Query: 248 VDACQSVPHMVVDVQKLNADFLVASSHKMC--GPTGIGFLYGKSDLLHSMPPFLGGGEMI 305 D S + VD+ + AD+ + ++K GP F++ L +P L G Sbjct: 200 WDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVWVSPQLCDLVPQPLSGWFGH 259 Query: 306 SDVFLDHSTYAEPP---SRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKY-- 360 S F Y EP +R+ GT I + +D + M + + + Sbjct: 260 SRQFAMEPRY-EPSNGIARYLCGTQPITSLAMVECGLDVFAQTDMASLRRKSLALTDLFI 318 Query: 361 -LYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLA 401 L E+ + ++ + PR E RG+ SF HP A Sbjct: 319 ELVEQRCAAHELTLVTPR--EHAKRGSHVSFE----HPEGYA 354 >1M32-A nrPDB Length = 366 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 3/95 (3%) Query: 201 PDINKLRELIS--PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMV 258 PD+ + +++ P +A+ H PI+E+ AH G +VDA S + Sbjct: 117 PDVQAIDAILNADPTISHIAMVHSETTTGMLNPIDEVGALAHRYGKTYIVDAMSSFGGIP 176 Query: 259 VDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLL 292 +D+ L+ D+L++S++K + G G F+ + L Sbjct: 177 MDIAALHIDYLISSANKCIQGVPGFAFVIAREQKL 211 >3QI6-A nrPDB Length = 392 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 69/159 (43%), Gaps = 29/159 (18%) Query: 159 LKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVP----DINKLRELISPKT 214 L+PGD V++ + ++++ + F N + P D++ +R I P T Sbjct: 102 LRPGDHVVIPDDAYGGT---FRLIDKV------FTGWNVEYTPVALADLDAVRAAIRPTT 152 Query: 215 KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSH 274 +L+ V +N L S I I D AKVLVD + P + + L AD ++ S+ Sbjct: 153 RLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPL-SLGADVVLHSTT 211 Query: 275 KMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHS 313 K G G SD+ +GG + +D LD S Sbjct: 212 KYIG--------GHSDV-------VGGALVTNDEELDQS 235 >4BMK-A nrPDB Length = 442 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 62/139 (44%), Gaps = 15/139 (10%) Query: 156 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINK-LRELISPKT 214 +S L E ++ A+ H+ I + Q +++F + V D++K L L Sbjct: 163 ISTLAGKGEYVILDADSHASI--YDGCQQGNAEIVRF---RHNSVEDLDKRLGRLPKEPA 217 Query: 215 KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM------VVDVQKLNA-- 266 KLV + V ++L P++E+V A GA VLVD S+ V + Q L Sbjct: 218 KLVVLEGVYSMLGDIAPLKEMVAVAKKHGAMVLVDEAHSMGFFGPNGRGVYEAQGLEGQI 277 Query: 267 DFLVASSHKMCGPTGIGFL 285 DF+V + G G GF+ Sbjct: 278 DFVVGTFSASVGTVG-GFV 295 >1GC4-A nrPDB Length = 385 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 50/105 (47%), Gaps = 9/105 (8%) Query: 135 REIVFTRNATEAINLVAYSWGLSNL-----KPGDEVILTVAEHHSCIVPWQIVSQKTGAV 189 RE + E I V S L NL PGDEVI V + P ++V G V Sbjct: 83 RENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVI--VLSPYWVSYP-EMVRFAGGVV 139 Query: 190 LKFVTLNEDE-VPDINKLRELISPKTKLVAVHHVSNVLASSLPIE 233 ++ TL E+ VPD ++R I+P+TK + V+ +N + P E Sbjct: 140 VEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKE 184 >1CS1-A nrPDB Length = 386 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 82/203 (40%), Gaps = 26/203 (12%) Query: 92 LQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVA 151 L + Y F N R H S + ++ ++ +A + + V T AI+LV Sbjct: 29 LSSTYNFTGFNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGA---VLTNTGMSAIHLVT 84 Query: 152 YSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQ--KTGAVLKFVTLNEDEVPDINKLREL 209 + LKPGD L VA H +++ K G DE LR Sbjct: 85 TVF----LKPGD---LLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDE----QALRAA 133 Query: 210 ISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFL 269 ++ K KLV V SN L + I +I A +VGA +VD P + + L AD + Sbjct: 134 LAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPAL-QNPLALGADLV 192 Query: 270 VASSHKMCGPTGIGFLYGKSDLL 292 + S K +L G SD++ Sbjct: 193 LHSCTK--------YLNGHSDVV 207 >6HRH-B nrPDB Length = 469 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 46/101 (45%), Gaps = 9/101 (8%) Query: 156 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPD-INKLRELISPKT 214 L+ + PG E+ H S I + KFV + D PD + KL E +PK Sbjct: 151 LAKILPGCEIYSDAGNHAS-----MIQGIRNSGAAKFVFRHND--PDHLKKLLEKSNPKI 203 Query: 215 -KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSV 254 K+VA V ++ + P+EE+ +H GA VD +V Sbjct: 204 PKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAV 244 >1XI9-A nrPDB Length = 406 Score = 34.7 bits (78), Expect = 0.100, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 112/268 (41%), Gaps = 33/268 (12%) Query: 119 ELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVP 178 E ++K I D R T TEA+ L+ +G + L PGDE+++ + Sbjct: 89 EREKRKNGVDITPDDVR---VTAAVTEALQLI---FG-ALLDPGDEILVPGPSYPPYT-- 139 Query: 179 WQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAVHHVSN---VLASSLPIEE 234 +V G +++ T+ E D PDI+ +R+ I+ +TK +AV + +N L +EE Sbjct: 140 -GLVKFYGGKPVEYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALYDKKTLEE 198 Query: 235 IVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGP----TGIGFLYGKSD 290 I+ A + V+ D + D+ + + S P G+ +Y + Sbjct: 199 ILNIAGEYEIPVISDE-------IYDLMTYEGEHISPGSLTKDVPVIVMNGLSKVYFATG 251 Query: 291 LLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIA-LGAAVDYLSGIGMPK 349 F+ +S+V A R TPA AIA L +DYL M K Sbjct: 252 WRLGYMYFVDPENKLSEVREAIDRLAR--IRLCPNTPAQFAAIAGLTGPMDYLKEY-MKK 308 Query: 350 IHEYEVEIGKYLYEKLSSLPDVRIYGPR 377 + E Y+Y++L+ +P + P+ Sbjct: 309 LKERR----DYIYKRLNEIPGISTTKPQ 332 >3VK2-A nrPDB Length = 398 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 57/124 (45%), Gaps = 12/124 (9%) Query: 154 WGLSNLKPGDEVIL--TVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELIS 211 W L L+PGDEV+L T+ H + I + G L+ V ++ D+ L ++ Sbjct: 98 WTL--LRPGDEVLLGNTLYGHTFAFLHHGI--GEFGVKLRHV-----DMADLQALEAAMT 148 Query: 212 PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVA 271 P T+++ +N I + A GA V+VD P++ ++ L AD +V Sbjct: 149 PATRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLE-LGADLVVH 207 Query: 272 SSHK 275 S+ K Sbjct: 208 SATK 211 >5V1X-E nrPDB Length = 501 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 86/216 (39%), Gaps = 22/216 (10%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNAT 144 P+A+ L++Y + + Y + DE +R VA + +VF NAT Sbjct: 59 PSAIQQKLRSYQTAAEARPCPFLRYQTPVLLDE---SRAAVANLLKVP-VETVVFVANAT 114 Query: 145 EAINLVAYS--WGLSNLKPGDEVILTVAEHHSCIVPWQ-IVSQKTGAV------LKFVTL 195 +N V + W DE++ +C ++ K G V L + Sbjct: 115 MGVNTVLRNIVWSADG---KDEILYFDTIFGACGKTIDYVIEDKRGIVSSRCIPLIYPAE 171 Query: 196 NEDEVPD----INKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 ++D V I K RE + +L + VS++ P E+IV + VD Sbjct: 172 DDDVVAAFRDAIKKSREE-GKRPRLAVIDVVSSMPGVRFPFEDIVKICKEEEIISCVDGA 230 Query: 252 QSVPHMVVDVQKLNADFLVASSHK-MCGPTGIGFLY 286 Q + + + + + + DFL+++ HK + P G Y Sbjct: 231 QGIGMVDLKITETDPDFLISNCHKWLFTPRGCAVFY 266 >3MKJ-A nrPDB Length = 398 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 4/92 (4%) Query: 204 NKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQK 263 ++R + P+TK+V + +N S + IE + AH GA ++VD P+ +Q Sbjct: 140 EEIRAAMRPETKVVYIETPANPTLSLVDIETVAGIAHQQGALLVVDNTFMSPYCQQPLQ- 198 Query: 264 LNADFLVASSHKMCGPTGI---GFLYGKSDLL 292 L AD +V S K G G + GK + + Sbjct: 199 LGADIVVHSVTKYINGHGDVIGGIIVGKQEFI 230 >3AEO-A nrPDB Length = 389 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 1/77 (1%) Query: 199 EVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMV 258 + D+ K++ P TK+V + +N I+ I V H+ GA+++VDA + P + Sbjct: 130 DTSDVEKVKAAWKPNTKMVYLESPANPTCKVSDIKGIAVVCHERGARLVVDATFTSPCFL 189 Query: 259 VDVQKLNADFLVASSHK 275 ++ L AD + S K Sbjct: 190 KPLE-LGADIALHSVSK 205 >3WKR-A nrPDB Length = 416 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 41/171 (23%), Positives = 72/171 (42%), Gaps = 25/171 (14%) Query: 125 VARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQ 184 +A+F+N +R T A E +V ++ K GD V+L H++ V + Sbjct: 106 IAKFLNMDCARP---THGAREGKFIVMHAI----CKEGDYVVLDKNAHYTSYVAAERAKL 158 Query: 185 KTGAVLKFVTLNEDEVP----DINKLRELI------SPKTKLVAVHHVSNVLASSLPIEE 234 V E+E P ++ +E+I L+ + HV + ++ Sbjct: 159 NVAEVG-----YEEEYPTYKINLEGYKEVIDNLEDKGKNVGLILLTHVDGEYGNLNDAKK 213 Query: 235 IVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK---MCGPTGI 282 + A + G L++ +V M V+ +++ ADF+VAS HK P GI Sbjct: 214 VGKIAKEKGIPFLLNCAYTVGRMPVNGKEVKADFIVASGHKSMAASAPCGI 264 >3MAF-B nrPDB Length = 518 Score = 33.1 bits (74), Expect = 0.30, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 55/143 (38%), Gaps = 17/143 (11%) Query: 164 EVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVS 223 E ++ V+ H + + +Q G L L+ D D+ +RE I+P T +VA Sbjct: 198 EAVVPVSAHAA----FDKAAQYFGIKLVRTPLDADYRADVAAMREAITPNTVVVAGSAPG 253 Query: 224 NVLASSLPIEEIVVWAHDVGAKVLVDAC-----------QSVPHMVVDVQKLNADFLVAS 272 PI EI A + G VDAC P D + + A Sbjct: 254 YPHGVVDPIPEIAALAAEHGIGCHVDACLGGFILPWAERLGYPVPPFDFRLEGVTSVSAD 313 Query: 273 SHKMC-GPTGIG-FLYGKSDLLH 293 +HK G G LY + DLLH Sbjct: 314 THKYGYGAKGTSVILYRRPDLLH 336 >2CB1-A nrPDB Length = 412 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 6/90 (6%) Query: 160 KPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAV 219 +PGDEV+ I + V G +++V P+ +RE +S KT+ V V Sbjct: 93 RPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVD------PEPEAVREALSAKTRAVFV 146 Query: 220 HHVSNVLASSLPIEEIVVWAHDVGAKVLVD 249 V+N +E + A + G ++VD Sbjct: 147 ETVANPALLVPDLEALATLAEEAGVALVVD 176 >3BB8-A nrPDB Length = 437 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 65/154 (42%), Gaps = 27/154 (17%) Query: 111 SAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYS------WGLSNLKPGDE 164 + + D FE KK+ ++ V T + + NL+A + G+ LKPGDE Sbjct: 60 TGRFNDAFE---KKLGEYLGVP----YVLTTTSGSSANLLALTALTSPKLGVRALKPGDE 112 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI----SPKTKLVAVH 220 VI A + + P + + G + FV ++ +P N LI S KTK + + Sbjct: 113 VITVAAGFPTTVNP----TIQNGLIPVFVDVD---IPTYNVNASLIEAAVSDKTKAIMIA 165 Query: 221 HVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSV 254 H L + + E+ A ++ D C ++ Sbjct: 166 H---TLGNLFDLAEVRRVADKYNLWLIEDCCDAL 196 >4J8L-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 33/151 (21%), Positives = 66/151 (43%), Gaps = 12/151 (7%) Query: 159 LKPGDEVILTVAEHHSCIVPW-QIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLV 217 LKPG +++ H + + P +++ ++ G L V N D++ L++++ + Sbjct: 87 LKPGQRLLV----HDAPVYPTTRVIIEQMGLTLITVDFN-----DLSALKQVVDEQQPDA 137 Query: 218 A-VHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM 276 A V H S + +++ G L D +V + + A+ S K+ Sbjct: 138 ALVQHTRQQPQDSYVLADVLATLRAAGVPALTDDNYAVMKVARIGCECGANVSTFSCFKL 197 Query: 277 CGPTGIGFLYGKSDLLHSMPPFL-GGGEMIS 306 GP G+G + G +D+++ + L GG I Sbjct: 198 FGPEGVGAVVGDADVINRIRATLYSGGSQIQ 228 >1IBJ-A nrPDB Length = 464 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 20/131 (15%) Query: 162 GDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHH 221 GD+V S +VP ++G V+K V + ++++ I P+TKLV + Sbjct: 177 GDDVYGGSDRLLSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGPQTKLVWLES 225 Query: 222 VSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTG 281 +N I +I AH GA VLVD P + ++ L AD ++ S+ K Sbjct: 226 PTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLE-LGADIVMHSATK------ 278 Query: 282 IGFLYGKSDLL 292 F+ G SD++ Sbjct: 279 --FIAGHSDVM 287 >1YIY-A nrPDB Length = 429 Score = 32.0 bits (71), Expect = 0.53, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 33/200 (16%) Query: 119 ELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVP 178 +L + V R IN E++ T A EA+ Y+ ++ GDEVI+ + C P Sbjct: 88 KLYSQLVDRTINPMT--EVLVTVGAYEAL----YATIQGHVDEGDEVII-IEPFFDCYEP 140 Query: 179 WQIVSQKTGAVLKFVTL----------NEDEVPDINKLRELISPKTKLVAVHHVSNVLAS 228 + + G + +F+ L + D V D N+L L + KTK++ ++ N L Sbjct: 141 ---MVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGK 197 Query: 229 SLPIEEIVVWAHDVGA-KVLVDACQSVPHMVVDVQK----------LNADFLVASSHKMC 277 + E+ V A+ VL + + HMV + + + S+ K Sbjct: 198 VMDRAELEVVANLCKKWNVLCVSDEVYEHMVFEPFEHIRICTLPGMWERTITIGSAGKTF 257 Query: 278 GPTG--IGFLYGKSDLLHSM 295 TG IG+ YG LL ++ Sbjct: 258 SLTGWKIGWAYGPEALLKNL 277 >2E7J-A nrPDB Length = 371 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 24/40 (60%), Gaps = 3/40 (7%) Query: 246 VLVDACQSVPHMVVDVQKLNADFLVASSHK---MCGPTGI 282 +LV+ ++ M V ++++ ADF+V S HK GP G+ Sbjct: 180 LLVNGAYAIGRMPVSLKEIGADFIVGSGHKSMAASGPIGV 219 >2X8U-A nrPDB Length = 412 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 10/103 (9%) Query: 191 KFVTLNEDEVPDINK-LRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVD 249 + V + V D++K L L + KLV + V +++ P++E+V + GA +LVD Sbjct: 151 EIVRFRHNSVEDLDKRLGRLPAEAGKLVVLEGVYSMMGDIAPLQEMVAVSKKHGAMILVD 210 Query: 250 ACQSVPHM------VVDVQKLNA--DFLVASSHKMCGPTGIGF 284 + V + + A DF+V + K G G GF Sbjct: 211 EAHGMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVG-GF 252 >5K0Z-A nrPDB Length = 331 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 7/82 (8%) Query: 355 VEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHG---VA 411 V+I Y+ KLS LP R+ G + R G+HPT ++ +HG VA Sbjct: 139 VDILTYVTWKLSGLPKHRVIGSGCNLDTARFRYLMAERLGIHPTSCHGWILGEHGDSSVA 198 Query: 412 IRSGHHCA----QPLHRYLGVN 429 + SG + A Q L+ +G + Sbjct: 199 VWSGVNVAGVSLQELNPAMGTD 220 >4KAM-A nrPDB Length = 453 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 55/145 (37%), Gaps = 29/145 (20%) Query: 185 KTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGA 244 K G + FV D+ +++ + + P TK +SN L + AH G Sbjct: 139 KLGIEVSFV----DDPDNLDSWQAAVRPNTKAFFGETISNPQIDLLDTPGVAEVAHRNGI 194 Query: 245 KVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGG-GE 303 ++VD + P+++ F G ++HS +LGG G Sbjct: 195 PLIVDNTIATPYLIRP-----------------------FTQGADIVVHSATKYLGGHGA 231 Query: 304 MISDVFLDHSTYAEPPSRF-EAGTP 327 I+ V +D T+ RF E TP Sbjct: 232 AIAGVIVDGGTFDWTQGRFPEFTTP 256 >3RI6-A nrPDB Length = 430 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 61/143 (42%), Gaps = 14/143 (9%) Query: 141 RNATEAINLVAYSWGLSNL--------KPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 +N T A+ ++A G++ + + GD V+ T + +Q G ++F Sbjct: 92 KNLTGALGVLALGSGMAAISTAILTLARAGDSVVTTDRLFGHTLSLFQKTLPSFGIEVRF 151 Query: 193 VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQ 252 V +V D + TKL+ + +SN +E + H G ++VD Sbjct: 152 V-----DVMDSLAVEHACDETTKLLFLETISNPQLQVADLEALSKVVHAKGIPLVVDTTM 206 Query: 253 SVPHMVVDVQKLNADFLVASSHK 275 + P++ ++ ++L D V SS K Sbjct: 207 TPPYL-LEAKRLGVDIEVLSSTK 228 >2Z9W-A nrPDB Length = 392 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 60/138 (43%), Gaps = 11/138 (7%) Query: 212 PKTKLVAVHHVSNVLASSLPIEEI--VVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFL 269 P+ +V+V H + PI+ I +V AH GA ++VDA S M + AD Sbjct: 133 PEITVVSVCHHDTPSGTINPIDAIGALVSAH--GAYLIVDAVSSFGGMKTHPEDCKADIY 190 Query: 270 VASSHKMCG-PTGIGFLYGKSDLLHSMP--PFLGGGEMISDVFLDHSTYAEPPSRFEAGT 326 V +K G P G+ + M P M+S V +++ + P F T Sbjct: 191 VTGPNKCLGAPPGLTMMGVSERAWAKMKANPLAPRASMLSIVDWENAWSRDKPFPF---T 247 Query: 327 PAIGEAIALGAAVD-YLS 343 P++ E L A+D YL+ Sbjct: 248 PSVSEINGLDVALDLYLN 265 >4L0O-H nrPDB Length = 388 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 50/123 (40%), Gaps = 6/123 (4%) Query: 156 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 215 S L+ GD V+L + + V K G + + DI+++++ I P TK Sbjct: 82 FSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTII-----DTSDISQIKKAIKPNTK 136 Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK 275 + + SN L + + A D G +VD + P+ + L AD + S K Sbjct: 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLL-LGADIVAHSGTK 195 Query: 276 MCG 278 G Sbjct: 196 YLG 198 >3DR4-A nrPDB Length = 391 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 49/124 (39%), Gaps = 22/124 (17%) Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 EFE A F + + + N T A++L + G+ PGDEVI+ + Sbjct: 60 EFEKA------FADYCGVKHAIACNNGTTALHLALVAMGIG---PGDEVIVPSLTY---- 106 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVP-----DINKLRELISPKTKLVAVHHVSNVLASSLP 231 I S + + D P D KL LI+P+TK + H+ + P Sbjct: 107 ----IASANSVTYCGATPVLVDNDPRTFNLDAAKLEALITPRTKAIMPVHLYGQICDMDP 162 Query: 232 IEEI 235 I E+ Sbjct: 163 ILEV 166 >1VJO-A nrPDB Length = 393 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 26/121 (21%), Positives = 56/121 (46%), Gaps = 3/121 (2%) Query: 159 LKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRE-LISPKTKLV 217 ++PGD V++ VA + + ++ + GA ++ ++ EV + +LR L + + ++ Sbjct: 106 VEPGDVVLIGVAGYFGNRL--VDMAGRYGADVRTISKPWGEVFSLEELRTALETHRPAIL 163 Query: 218 AVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMC 277 A+ H + P+E + + G +LVD S+ + + + D + S K Sbjct: 164 ALVHAETSTGARQPLEGVGELCREFGTLLLVDTVTSLGGVPIFLDAWGVDLAYSCSQKGL 223 Query: 278 G 278 G Sbjct: 224 G 224 >6EOT-A nrPDB Length = 898 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 23/52 (44%), Gaps = 1/52 (1%) Query: 383 HRGALCSFNVEGLHPTDLATFLDQQHGVAI-RSGHHCAQPLHRYLGVNASAR 433 H L SF V P DL + ++H + + SG H L YL N +R Sbjct: 840 HTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSR 891 >5TSU-A nrPDB Length = 422 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 5/90 (5%) Query: 159 LKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVA 218 LK GD++I + + ++ V+ + G + FV + I L I+P+TKLV Sbjct: 118 LKAGDQIICMDDVYGGTNLYFRQVASEFGLKISFV-----DCSKIKLLEAAITPETKLVW 172 Query: 219 VHHVSNVLASSLPIEEIVVWAHDVGAKVLV 248 + +N + IE H G +LV Sbjct: 173 IETPTNPTQKVIDIEGCAHIVHKHGDIILV 202 >1J32-A nrPDB Length = 388 Score = 28.1 bits (61), Expect = 8.7, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 30/100 (30%) Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVIL------------TVAEHHSCIVPWQIVSQ 184 I+ T ++I ++ L+ ++PGDEVI+ +AE I+P + +Q Sbjct: 93 ILVTNGGKQSI----FNLMLAMIEPGDEVIIPAPFWVSYPEMVKLAEGTPVILPTTVETQ 148 Query: 185 KTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSN 224 F E ++R+ I+PKTKL+ + SN Sbjct: 149 -------FKVSPE-------QIRQAITPKTKLLVFNTPSN 174 >4CVQ-A nrPDB Length = 431 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 30/148 (20%), Positives = 66/148 (44%), Gaps = 21/148 (14%) Query: 121 ARKKVARFINASDSREI----VFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 ARK + + A R++ ++ N + + A + L GDE+++ ++ Sbjct: 103 ARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQ---ALLNSGDEMLVPAPDYPLWT 159 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSN----VLASSLPI 232 + S K AV + D PD++ +R I+P+T+ + + + +N V + L + Sbjct: 160 AAVSLSSGK--AVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLM 217 Query: 233 E--------EIVVWAHDVGAKVLVDACQ 252 E ++++A ++ K+L D + Sbjct: 218 EIVEIARQHNLIIFADEIYDKILYDDAE 245 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4Q75-A nrPDB 607 e-174 1T3I-A nrPDB 558 e-159 5XT5-A nrPDB 537 e-153 4W91-A nrPDB 511 e-145 6C9E-A nrPDB 506 e-144 6MRE-A nrPDB 505 e-143 5VPR-A nrPDB 498 e-141 4LW2-A nrPDB 450 e-127 5WT2-A nrPDB 333 1e-91 1ECX-A nrPDB 332 1e-91 3LVM-A nrPDB 316 1e-86 5WGB-A nrPDB 315 2e-86 3A9Z-A nrPDB 302 2e-82 3GZD-A nrPDB 287 6e-78 4ISY-A nrPDB 285 2e-77 3CAI-A nrPDB 282 2e-76 4EB7-A nrPDB 282 2e-76 5HH9-A nrPDB 256 2e-68 1QZ9-A nrPDB 245 3e-65 3OP7-A nrPDB 118 5e-27 1M32-A nrPDB 112 5e-25 Sequences not found previously or not previously below threshold: 1VJO-A nrPDB 94 9e-20 4Q6R-A nrPDB 84 1e-16 2DR1-A nrPDB 84 1e-16 3MAF-B nrPDB 84 2e-16 3KGX-A nrPDB 82 5e-16 2YRI-A nrPDB 80 2e-15 3E9K-A nrPDB 79 5e-15 3ISL-A nrPDB 75 7e-14 2Z9W-A nrPDB 74 1e-13 2BKW-A nrPDB 69 4e-12 5V1X-E nrPDB 69 4e-12 5LUC-A nrPDB 69 5e-12 3ZRR-A nrPDB 68 1e-11 3NNK-A nrPDB 67 1e-11 1XI9-A nrPDB 66 3e-11 2E7J-A nrPDB 66 3e-11 5DX5-A nrPDB 65 7e-11 3F9T-A nrPDB 64 1e-10 3WKR-A nrPDB 64 1e-10 2CH1-A nrPDB 62 6e-10 4BMK-A nrPDB 61 8e-10 5K1R-A nrPDB 61 9e-10 4W8I-A nrPDB 61 1e-09 1V2E-A nrPDB 61 1e-09 3VK2-A nrPDB 60 2e-09 3NYS-A nrPDB 60 3e-09 4OBV-D nrPDB 59 4e-09 2HUU-A nrPDB 57 1e-08 3AEO-A nrPDB 57 1e-08 4M2J-A nrPDB 57 2e-08 3RI6-A nrPDB 57 2e-08 1O4S-A nrPDB 56 3e-08 4OTL-A nrPDB 56 3e-08 3MKJ-A nrPDB 56 5e-08 3FFH-A nrPDB 55 6e-08 4U1T-A nrPDB 55 7e-08 3QI6-A nrPDB 55 8e-08 4KAM-A nrPDB 55 8e-08 1J32-A nrPDB 54 1e-07 1IBJ-A nrPDB 54 1e-07 2CB1-A nrPDB 54 2e-07 5K8B-A nrPDB 54 2e-07 3WY7-A nrPDB 53 2e-07 5O5C-A nrPDB 53 3e-07 3UWC-A nrPDB 53 3e-07 2CTZ-A nrPDB 52 4e-07 1GC4-A nrPDB 52 6e-07 4IYO-A nrPDB 51 9e-07 4J8L-A nrPDB 51 1e-06 3DR4-A nrPDB 50 2e-06 2GB3-A nrPDB 50 2e-06 4L0O-H nrPDB 50 3e-06 5X5H-A nrPDB 50 3e-06 2GMS-A nrPDB 50 3e-06 2X8U-A nrPDB 49 4e-06 3VOM-A nrPDB 49 4e-06 2O0R-A nrPDB 49 4e-06 1CS1-A nrPDB 49 5e-06 1B9H-A nrPDB 48 7e-06 3FFR-A nrPDB 48 9e-06 1M6S-A nrPDB 47 1e-05 6HRH-B nrPDB 47 2e-05 3MC6-C nrPDB 47 2e-05 4CVQ-A nrPDB 47 2e-05 2OGE-A nrPDB 46 3e-05 5HSI-A nrPDB 46 3e-05 5TSU-A nrPDB 46 4e-05 1O69-A nrPDB 45 6e-05 5F8V-A nrPDB 45 6e-05 3BB8-A nrPDB 45 7e-05 4ZWV-A nrPDB 45 7e-05 4BHD-A nrPDB 45 8e-05 1I43-A nrPDB 45 8e-05 3E77-A nrPDB 45 9e-05 1E5F-A nrPDB 45 9e-05 3WGB-A nrPDB 44 9e-05 3ASB-A nrPDB 44 1e-04 1U08-A nrPDB 44 2e-04 1PFF-A nrPDB 44 2e-04 1BJO-A nrPDB 44 2e-04 3ELE-A nrPDB 44 2e-04 3H7F-A nrPDB 43 2e-04 4AOA-A nrPDB 43 2e-04 5YHV-A nrPDB 43 3e-04 3NRA-A nrPDB 42 4e-04 5U24-A nrPDB 42 4e-04 1YJS-A nrPDB 42 7e-04 3LY1-A nrPDB 42 7e-04 1LC8-A nrPDB 41 0.001 1WYT-A nrPDB 41 0.001 2C81-A nrPDB 41 0.001 2DOU-A nrPDB 40 0.002 4MY5-A nrPDB 39 0.003 4OC9-A nrPDB 39 0.004 3PJ0-A nrPDB 39 0.004 2QMA-A nrPDB 39 0.004 3TQX-A nrPDB 39 0.006 2JIS-A nrPDB 38 0.007 1M4N-A nrPDB 38 0.011 5VNX-A nrPDB 38 0.011 6EEQ-A nrPDB 38 0.011 3IHJ-A nrPDB 37 0.012 4RIT-B nrPDB 37 0.015 6ENZ-A nrPDB 37 0.016 1IAY-A nrPDB 37 0.019 5JAY-A nrPDB 37 0.020 6F77-B nrPDB 37 0.020 3PGY-A nrPDB 37 0.022 3NX3-A nrPDB 37 0.023 6ONN-A nrPDB 37 0.025 6JRL-A nrPDB 36 0.034 6EEI-A nrPDB 36 0.039 4FL0-A nrPDB 36 0.041 3NTJ-A nrPDB 36 0.042 3HQT-A nrPDB 36 0.049 6F35-A nrPDB 35 0.059 3CIA-A nrPDB 35 0.080 6CJB-A nrPDB 35 0.093 1N8P-A nrPDB 34 0.14 3RUY-A nrPDB 33 0.32 2OKJ-A nrPDB 33 0.33 3JTX-A nrPDB 32 0.39 5M99-B nrPDB 32 0.59 1FC4-A nrPDB 32 0.63 2OKK-A nrPDB 32 0.65 2O1B-A nrPDB 32 0.76 3LRP-A nrPDB 32 0.79 1NW6-A nrPDB 31 1.2 4EFI-A nrPDB 31 1.4 2X5F-A nrPDB 31 1.4 4AK9-A nrPDB 31 1.8 3DM5-A nrPDB 30 1.9 4R2N-A nrPDB 30 2.0 5L3P-c nrPDB 30 2.4 4KDR-A nrPDB 30 2.5 4KDC-A nrPDB 30 2.5 2C44-A nrPDB 30 2.8 5B5R-A nrPDB 29 3.3 5HX2-G nrPDB 29 3.8 4FHN-X nrPDB 29 3.9 6EEW-A nrPDB 29 4.3 2YFH-A nrPDB 29 5.3 4TLV-A nrPDB 28 7.9 >4Q75-A nrPDB Length = 429 Score = 607 bits (1565), Expect = e-174, Method: Composition-based stats. Identities = 428/428 (100%), Positives = 428/428 (100%) Query: 36 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY 95 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY Sbjct: 2 AAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNY 61 Query: 96 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG 155 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG Sbjct: 62 YEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWG 121 Query: 156 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 215 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK Sbjct: 122 LSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 181 Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK 275 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK Sbjct: 182 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK 241 Query: 276 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL 335 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL Sbjct: 242 MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIAL 301 Query: 336 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL 395 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL Sbjct: 302 GAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL 361 Query: 396 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 455 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT Sbjct: 362 HPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 421 Query: 456 VSFFNSFK 463 VSFFNSFK Sbjct: 422 VSFFNSFK 429 >1T3I-A nrPDB Length = 420 Score = 558 bits (1438), Expect = e-159, Method: Composition-based stats. Identities = 258/410 (62%), Positives = 310/410 (75%), Gaps = 2/410 (0%) Query: 52 SLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLS 111 SL VR+DF IL+QE+NG LVYLD+AATSQKP AVL+ L +YYE N+NVHRG H LS Sbjct: 8 SLAATVRQDFPILNQEINGHPLVYLDNAATSQKPRAVLEKLMHYYENDNANVHRGAHQLS 67 Query: 112 AKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAE 171 +ATD +E R KVA+FINA REIV+TRNATEAINLVAYSWG++NLK GDE+I TV E Sbjct: 68 VRATDAYEAVRNKVAKFINARSPREIVYTRNATEAINLVAYSWGMNNLKAGDEIITTVME 127 Query: 172 HHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP 231 HHS +VPWQ+V+ KTGAVLKFV L+E E D+ + L+S KTKLV V H+SN L P Sbjct: 128 HHSNLVPWQMVAAKTGAVLKFVQLDEQESFDLEHFKTLLSEKTKLVTVVHISNTLGCVNP 187 Query: 232 IEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDL 291 EEI AH GAKVLVDACQS PH +DVQ ++ D+LVAS HKMC PTGIGFLYGK ++ Sbjct: 188 AEEIAQLAHQAGAKVLVDACQSAPHYPLDVQLIDCDWLVASGHKMCAPTGIGFLYGKEEI 247 Query: 292 LHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIH 351 L +MPPF GGGEMI++VF DH T E P +FEAGTPAI EAIALGAAVDYL+ +GM IH Sbjct: 248 LEAMPPFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAVDYLTDLGMENIH 307 Query: 352 EYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVA 411 YEVE+ YL++ L +P +R+YGP P R AL SFNV GLH +D+AT +DQ G+A Sbjct: 308 NYEVELTHYLWQGLGQIPQLRLYGPNPKHG-DRAALASFNVAGLHASDVATMVDQD-GIA 365 Query: 412 IRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 IRSGHHC QPLHR + SARASLYFYNTK+++D F+ +L T+ FF+ Sbjct: 366 IRSGHHCTQPLHRLFDASGSARASLYFYNTKEEIDLFLQSLQATIRFFSD 415 >5XT5-A nrPDB Length = 419 Score = 537 bits (1383), Expect = e-153, Method: Composition-based stats. Identities = 210/405 (51%), Positives = 278/405 (68%), Gaps = 6/405 (1%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R+ F ILHQ+VNG LVYLDSAATSQKP AV++ L YY YNSNVHRG+H L +ATD Sbjct: 9 IREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATD 68 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 +E AR+KV +FINA EI+FT+ T ++N+VA S+ +NLKPGDEV++T EHH+ I Sbjct: 69 GYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVITYMEHHANI 128 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 +PWQ + TGA LK++ L ED + +RE ++ TK+VAV HVSNVL + PI+E+ Sbjct: 129 IPWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMA 188 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMP 296 AHD GA ++VD QS PHM +DVQ L+ DF SSHKMCGPTG+G LYGK LL +M Sbjct: 189 KIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENME 248 Query: 297 PFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVE 356 P GGEMI V L ST+ E P +FEAGTP I AI LGAA+D+L IG+ +I +E + Sbjct: 249 PAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEISRHEHK 308 Query: 357 IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGH 416 + Y E+ L V +YGP R L +FN++ +HP D+AT LD + G+A+R+GH Sbjct: 309 LAAYALERFRQLDGVTVYGPE-----ERAGLVTFNLDDVHPHDVATVLDAE-GIAVRAGH 362 Query: 417 HCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 HCAQPL ++L V A+ARAS Y YNT++++D + AL T +F + Sbjct: 363 HCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTKEYFTN 407 >4W91-A nrPDB Length = 422 Score = 511 bits (1315), Expect = e-145, Method: Composition-based stats. Identities = 188/403 (46%), Positives = 270/403 (66%), Gaps = 5/403 (1%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R+DF IL ++V+G LVYLD+ A++QKP +V+DA+ + Y +NVHRG+H+LS ATD Sbjct: 24 IRRDFPILSRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATD 83 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 +E +R+ V RF+NA EIVFT+NATEAIN VAY +G+ + GDE++L++ EHHS I Sbjct: 84 AYEKSRETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNI 143 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 VPW + ++ GA L F ++++ V I + + +S +TKLVA+ H+SN L + +PI++IV Sbjct: 144 VPWHFIRERQGAKLVFTPVDDNGVFHIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKIV 203 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMP 296 AH G VLVD Q H+ VDVQ L D+ V + HK+ GP+GIG LYG++ +L M Sbjct: 204 ELAHARGIPVLVDGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSGIGVLYGRAQMLEKMR 263 Query: 297 PFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVE 356 PF GGGEMI +V ++ TY PP RFEAGTP I +AI LGAA++Y+ IG I +E + Sbjct: 264 PFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILAHEAD 323 Query: 357 IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGH 416 + Y +E+L + +RI+G P +GA+ SF +EG+H D++ +D+ GVA+R+G Sbjct: 324 LRDYAHERLGRINSLRIFGNAPD----KGAIISFALEGIHAHDVSMVIDRA-GVAVRAGT 378 Query: 417 HCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 HCAQPL + GV ++ RAS YNT+ +VDA AL FF Sbjct: 379 HCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKARKFF 421 >6C9E-A nrPDB Length = 422 Score = 506 bits (1303), Expect = e-144, Method: Composition-based stats. Identities = 180/405 (44%), Positives = 259/405 (63%), Gaps = 5/405 (1%) Query: 55 HRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKA 114 +++RKDF +LHQ++N LVY D+AAT+QKP AV+DA+ +YE NSNVHRG+H LS +A Sbjct: 22 NKIRKDFPVLHQKINEYDLVYFDNAATTQKPKAVIDAIAQFYEKDNSNVHRGVHALSVRA 81 Query: 115 TDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHS 174 T+ +E AR KV RFINA RE +F R TEAINLVA S + P +E+++T EHHS Sbjct: 82 TEMYEAARAKVKRFINARSPRECIFVRGTTEAINLVAQSLVAPRILPDEEILITHMEHHS 141 Query: 175 CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEE 234 IVPWQ+V +K G L+ ++ + + + ++ TK+VA+++ SN L + P++ Sbjct: 142 NIVPWQMVCKKMGCKLQVAPISLNGEVILEEFERKLNENTKMVAINYASNSLGTINPVKT 201 Query: 235 IVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHS 294 ++ AH+VGAKVL+D Q+ H++VDVQ L+ DF S HKM GPTGIG L+GK +LL+S Sbjct: 202 MIKMAHEVGAKVLLDGAQATAHLIVDVQDLDCDFYAFSGHKMYGPTGIGVLWGKEELLNS 261 Query: 295 MPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYE 354 M P+ GGGEMI+ V + + YA P +FEAGTP I AI L AA+DY+ + + I EYE Sbjct: 262 MTPYQGGGEMINSVSFEATEYAAIPHKFEAGTPNIAGAIGLAAAIDYIWSLDLDAIAEYE 321 Query: 355 VEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRS 414 ++ Y + + ++ I G + ++ + SF +H D+ T LD + G+AIRS Sbjct: 322 TQLLNYATKAIEAVKGYNIIGT----AANKVPIISFVHGKIHAHDIGTILDSE-GIAIRS 376 Query: 415 GHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 GHHC PL + V A++R S+ FYNT ++D + AL F Sbjct: 377 GHHCTMPLMDFYDVAATSRISMSFYNTFKEIDYCMEALQRVKEVF 421 >6MRE-A nrPDB Length = 420 Score = 505 bits (1300), Expect = e-143, Method: Composition-based stats. Identities = 192/405 (47%), Positives = 260/405 (64%), Gaps = 7/405 (1%) Query: 56 RVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKAT 115 +VR DF +L +EVNG L YLDSAA++QKP+ V+DA +Y + VHRGIH LSA+AT Sbjct: 21 KVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQAT 80 Query: 116 DEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSC 175 ++ E RK+ + FINA + E+VF TE INLVA SWG SN++ GD +I++ EHH+ Sbjct: 81 EKMENVRKRASLFINARSAEELVFVAGTTEGINLVANSWGNSNVRAGDNIIISQMEHHAN 140 Query: 176 IVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI 235 IVPWQ++ + GA L+ + LN D + L L KT+L+A+ HVSNVL + P+ E+ Sbjct: 141 IVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEM 200 Query: 236 VVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSM 295 + AH GAKVLVD Q+V H VDVQ L+ DF V S HK+ GPTGIG LY K LL M Sbjct: 201 ITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEM 260 Query: 296 PPFLGGGEMISDVFL-DHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYE 354 PP+ GGG MI+ V L + +T+ + P RFEAGTP G I LGAA++Y+S +G+ I EYE Sbjct: 261 PPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYE 320 Query: 355 VEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRS 414 + Y +L S+PD+ +YGP+ +R + +FN+ H D+ +FLD +G+A+R+ Sbjct: 321 QNLMHYALSQLESVPDLTLYGPQ-----NRLGVIAFNLGKHHAYDVGSFLD-NYGIAVRT 374 Query: 415 GHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 GHHCA PL Y V A RASL YNT ++VD + L Sbjct: 375 GHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRIHRLL 419 >5VPR-A nrPDB Length = 414 Score = 498 bits (1283), Expect = e-141, Method: Composition-based stats. Identities = 187/407 (45%), Positives = 252/407 (61%), Gaps = 8/407 (1%) Query: 55 HRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKA 114 +R F IL ++VNG LVYLD+AATSQKP VLDA+ NYYE YN+NVHRGIH LS A Sbjct: 13 QEIRSQFPILQEKVNGKDLVYLDNAATSQKPKMVLDAINNYYEHYNANVHRGIHTLSQVA 72 Query: 115 TDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHS 174 T+ E ARKKV RFINA E++FT+ TE INLVAY+ +K DE+I++ EHHS Sbjct: 73 TEMMEDARKKVQRFINAKHDYEVLFTKGTTEGINLVAYAMT-DLIKKDDEIIISYLEHHS 131 Query: 175 CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEE 234 IVPWQ++ Q+TGA L+ + +NED I+ L E +S KTKLV+V+ VSN L PI+E Sbjct: 132 NIVPWQMLCQRTGAKLRVIPMNEDGTLQIDVLDEWLSEKTKLVSVNQVSNALGIVNPIDE 191 Query: 235 IVVWAHDV-GAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLH 293 I+ A + +D Q+ PH +DVQ ++ DF S HKM GPTG G LYGK+ +L Sbjct: 192 IIRKVRAKSNAFIFIDGAQAAPHFEIDVQTMDCDFFAFSGHKMYGPTGTGILYGKASVLE 251 Query: 294 SMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEY 353 + PF GGGEMI + +TYA P RFEAGTP I IA+G AVD++ +G I + Sbjct: 252 QLNPFHGGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAIGTAVDFMEKVGRSNIAAH 311 Query: 354 EVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLH-PTDLATFLDQQHGVAI 412 E + +Y KL + +++YG E +R + SFN+ G+ +D+ LD+ G+A+ Sbjct: 312 EHALLEYAQRKLLEIEGLKVYG----EKANRAGVVSFNLSGIGIASDVGMILDKL-GIAV 366 Query: 413 RSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 R+GHHC QP+ Y GV + RAS YNT +++D + Sbjct: 367 RTGHHCTQPIMEYFGVAGTVRASFAVYNTFEEIDILTEGVKKAQKML 413 >4LW2-A nrPDB Length = 404 Score = 450 bits (1157), Expect = e-127, Method: Composition-based stats. Identities = 162/405 (40%), Positives = 242/405 (59%), Gaps = 12/405 (2%) Query: 55 HRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKA 114 + R F L VYLDSAAT+ KP AV++A Q +Y NVHR + + Sbjct: 10 AQFRAQFPALQ-----DAGVYLDSAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRL 64 Query: 115 TDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHS 174 T +E AR+KVA+ +NA D + IV+TR TE+IN+VA + L+PGDE+I++VAEHH+ Sbjct: 65 TARYEAAREKVAQLLNAPDDKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHA 124 Query: 175 CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEE 234 +VPW +V+Q+TGA + + LN +PD++ L ELI+P+++++A+ +SNV + Sbjct: 125 NLVPWLMVAQQTGAKVVKLPLNAQRLPDVDLLPELITPRSRILALGQMSNVTGGCPDLAR 184 Query: 235 IVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHS 294 + +AH G V+VD Q H DVQ+L+ DF S HK+ GPTGIG LYGKS+LL + Sbjct: 185 AITFAHSAGMVVMVDGAQGAVHFPADVQQLDIDFYAFSGHKLYGPTGIGVLYGKSELLEA 244 Query: 295 MPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYE 354 M P+LGGG+M+ +V D T P + EAGTP + I L AA+++L+ + + + Sbjct: 245 MSPWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWS 304 Query: 355 VEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRS 414 + + L+ P R + R +S +L +F+ G+H +D+ T L ++G+A+R+ Sbjct: 305 RSLATLAEDALAKRPGFRSF--RCQDS----SLLAFDFAGVHHSDMVTLL-AEYGIALRA 357 Query: 415 GHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 G HCAQPL LGV + RAS YNTK DVDA + A+ + Sbjct: 358 GQHCAQPLLAELGVTGTLRASFAPYNTKSDVDALVNAVDRALELL 402 >5WT2-A nrPDB Length = 401 Score = 333 bits (854), Expect = 1e-91, Method: Composition-based stats. Identities = 105/396 (26%), Positives = 175/396 (44%), Gaps = 38/396 (9%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 +YLD+ AT++ V + + + + N +H + A K+ + INA D Sbjct: 5 IYLDNNATTRIDPKVKEIMDPFLRDHYGNP-SSLHQFGTETHPAIAEALDKLYKGINARD 63 Query: 134 SREIVFTRNATEAINLVAYSWGLSN-LKPGD-EVILTVAEHHSCIVPWQIVSQKTGAVLK 191 +++ T ATE+ N V LK G ++ TVAEH + + + G + Sbjct: 64 IDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFL-ESLGVEVT 122 Query: 192 FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 ++ +NE ++RE I+ KT LV+V +N PIEEI + G DA Sbjct: 123 YLPINEHGSITAEQVREAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAV 182 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLD 311 Q++ + VDV K NADFL S+HK GP GIG LY +S + + P GGE ++ Sbjct: 183 QAIGKIPVDVLKANADFLSFSAHKFHGPKGIGGLYIRSGV--GLTPLFHGGEHMNGR--- 237 Query: 312 HSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDV 371 +GT + + +G A+ L+ + E ++ L E L +PDV Sbjct: 238 -----------RSGTLNVPYIVGMGEAMK-LAVEHLDYEKEVVGKLRDKLEEALLKIPDV 285 Query: 372 RIYGPRPSESVHRGALCSF-NVEGLHPTDLATFLDQQHGVAIRSGHHCAQ------PLHR 424 + G R +HR + +V G+ + L++ + +A +G CA P+ Sbjct: 286 MVVGDR----IHRVPNTTLVSVRGIEGEAMLWDLNRSN-IAASTGSACASEDLEANPVMV 340 Query: 425 YLGVN-----ASARASLYFYNTKDDVDAFIVALADT 455 +G + + R SL +NT+ ++D I + Sbjct: 341 AIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQA 376 >1ECX-A nrPDB Length = 384 Score = 332 bits (852), Expect = 1e-91, Method: Composition-based stats. Identities = 92/400 (23%), Positives = 175/400 (43%), Gaps = 38/400 (9%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 VY D+ AT++ VL+ + +Y N + H + +A E AR+KVA+ + Sbjct: 3 VYFDNNATTRVDDRVLEEMIVFYREKYGNPNSA-HGMGIEANLHMEKAREKVAKVLG-VS 60 Query: 134 SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFV 193 EI FT ATE+IN + + + K +I T EH + + + +S K G +K+V Sbjct: 61 PSEIFFTSCATESINWILKTVAETFEKRKRTIITTPIEHKAVLETMKYLSMK-GFKVKYV 119 Query: 194 TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVG--AKVLVDAC 251 ++ V + +L +L+ T LV++ +N + + P+E++ V VDA Sbjct: 120 PVDSRGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVTRIVKKKNKETLVHVDAV 179 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLD 311 Q++ + ++KL D+ S+HK GP G+G Y + + + P + GG Sbjct: 180 QTIGKIPFSLEKLEVDYASFSAHKFHGPKGVGITYIRKGV--PIRPLIHGGGQERG---- 233 Query: 312 HSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDV 371 +GT + + A++ I + ++ E + K + +S L ++ Sbjct: 234 ----------LRSGTQNVPGIVGAARAME----IAVEELSEAAKHMEKLRSKLVSGLMNL 279 Query: 372 RIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQP------LHRY 425 + P E + S + + + L L +G+ + + C + Sbjct: 280 GAHIITPLE-ISLPNTLSVSFPNIRGSTLQNLL-SGYGIYVSTSSACTSKDERLRHVLDA 337 Query: 426 LGVN-----ASARASLYFYNTKDDVDAFIVALADTVSFFN 460 +GV+ + R SL YNT+++VD F+ + + +SF + Sbjct: 338 MGVDRRIAQGAIRISLCKYNTEEEVDYFLKKIEEILSFLD 377 >3LVM-A nrPDB Length = 423 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 92/396 (23%), Positives = 162/396 (40%), Gaps = 36/396 (9%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYN--SNVHRGIHYLSAKATDEFELARKKVARFINA 131 +YLD +AT+ V + + + N H +A + ++AR ++A + A Sbjct: 24 IYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGA 83 Query: 132 SDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLK 191 D REIVFT ATE+ NL K G +I + EH + + + + ++ G + Sbjct: 84 -DPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQL-EREGFEVT 141 Query: 192 FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 ++ + + D+ +L + T LV++ HV+N + I I G VDA Sbjct: 142 YLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDAT 201 Query: 252 QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLD 311 QSV + +D+ +L D + S HK+ GP GIG LY + + + GG Sbjct: 202 QSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERG---- 257 Query: 312 HSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDV 371 +GT + + + +G A ++ M E + L+ + + +V Sbjct: 258 ----------MRSGTLPVHQIVGMGEAYR-IAKEEMATEMERLRGLRNRLWNGIKDIEEV 306 Query: 372 RIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQP------LHRY 425 + G SFN + L L +A+ SG C + R Sbjct: 307 YLNGD-LEHGAPNILNVSFNY--VEGESLIMALKD---LAVSSGSACTSASLEPSYVLRA 360 Query: 426 LGVN-----ASARASLYFYNTKDDVDAFIVALADTV 456 LG+N +S R SL + T++++D I + ++ Sbjct: 361 LGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSI 396 >5WGB-A nrPDB Length = 426 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 96/398 (24%), Positives = 160/398 (40%), Gaps = 36/398 (9%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 +Y+D AT+ VLDA+ Y Y N H H ++ E AR++VA I A D Sbjct: 28 LYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGA-D 86 Query: 134 SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFV 193 REI+FT ATE+ N+ +I T EH + + + + G + ++ Sbjct: 87 PREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSL-EAEGFQVTYL 145 Query: 194 TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQS 253 + + + D+ +L I P T LV+V V+N + PI EI DA Q+ Sbjct: 146 PVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQA 205 Query: 254 VPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHS 313 V + +DV + D + S HK+ GP G+G +Y + + GG Sbjct: 206 VGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERG------ 259 Query: 314 TYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKL-SSLPDVR 372 +GT + LGAA + ++ M H+ ++ + L + + SLPDV Sbjct: 260 --------MRSGTVPTPLVVGLGAACE-VAQQEMEYDHKRISKLSERLIQNIMKSLPDVV 310 Query: 373 IYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQP------LHRYL 426 + G H + + + L L VA+ SG C + R + Sbjct: 311 MNG---DPKHHYPGCINLSFAYVEGESLLMALKD---VALSSGSACTSASLEPSYVLRAI 364 Query: 427 GVN-----ASARASLYFYNTKDDVDAFIVA-LADTVSF 458 G + +S R + + T+++VD + + Sbjct: 365 GTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIQHVKRL 402 >3A9Z-A nrPDB Length = 432 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 99/429 (23%), Positives = 157/429 (36%), Gaps = 63/429 (14%) Query: 71 SKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN 130 ++ VY+D AT+ V+ A+ + N + KA D AR +A+ I Sbjct: 17 NRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMIG 75 Query: 131 ASDSREIVFTRNATEAINLVAYS-------------WGLSNLKPGD----EVILTVAEHH 173 ++I+FT TE+ NLV +S + + P + I EH Sbjct: 76 GK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHD 134 Query: 174 SCIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAVHHVSNVLASSLPI 232 S +P + + + A + FV +++ + ++ + + P T LV + +N +PI Sbjct: 135 SIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPI 194 Query: 233 EEIVVWAHDVG----------AKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGI 282 EI + V DA Q++ VDV+ L DFL HK GP I Sbjct: 195 SEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-I 253 Query: 283 GFLYGK--SDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVD 340 G LY + L P GGG+ F GT LG A D Sbjct: 254 GALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAAD 298 Query: 341 YLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGAL-CSFNVEGLHPTD 399 +S + +I YL E+L + RI+ V R C+F+++G Sbjct: 299 LVSEN-CETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRG 357 Query: 400 LATFLDQQHGVAIRSGHHC-------AQPLHRYLGVN-----ASARASLYFYNTKDDVDA 447 L Q + G C P+ G+ + R S+ T+ +VD Sbjct: 358 Y-MVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDL 416 Query: 448 FIVALADTV 456 + L V Sbjct: 417 IVQDLKQAV 425 >3GZD-A nrPDB Length = 440 Score = 287 bits (735), Expect = 6e-78, Method: Composition-based stats. Identities = 93/429 (21%), Positives = 153/429 (35%), Gaps = 64/429 (14%) Query: 72 KLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINA 131 + VY+D AT+ V+ A+ N + KA D AR+ +A+ I Sbjct: 25 RKVYMDYNATTPLEPEVIQAMTKAMWEAWGNP-SSPYSAGRKAKDIINAARESLAKMIGG 83 Query: 132 SDSREIVFTRNATEAINLVAYSWG-----------------LSNLKPGDEVILTVAEHHS 174 ++I+FT TE+ NLV +S I + EH S Sbjct: 84 K-PQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDS 142 Query: 175 CIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIE 233 +P + + ++ A + FV +++ +++ + + P T+LV + +N +P+ Sbjct: 143 IRLPLEHLVEEQVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVP 202 Query: 234 EIVVWAHDVGA----------KVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIG 283 EI + V DA Q++ VDV+ L DFL HK GP IG Sbjct: 203 EISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IG 261 Query: 284 FLYGK--SDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDY 341 LY + + P GGG+ F GT LG A + Sbjct: 262 ALYIRGLGEFTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAAEL 306 Query: 342 LSGIGMPKIHEYEVEIGKYLYEKLSSLPD-VRIYGPRPSESVHRGAL-CSFNVEGLHPTD 399 ++ + ++ YL E+L + RI+ R C+F++ G Sbjct: 307 VTQN-CEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQG 365 Query: 400 LATFLDQQHGVAIRSGHHC-------AQPLHRYLGVN-----ASARASLYFYNTKDDVDA 447 L Q + G C P+ GV + R S+ T+ +VD Sbjct: 366 HV-VLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDL 424 Query: 448 FIVALADTV 456 + L V Sbjct: 425 VVQDLKQAV 433 >4ISY-A nrPDB Length = 404 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 101/399 (25%), Positives = 159/399 (39%), Gaps = 46/399 (11%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 YLD AAT+ A ++A+ + +H A E AR+ +A + A Sbjct: 13 AYLDHAATTPMHPAAIEAMAAVQRTIGN--ASSLHTSGRSARRRIEEARELIADKLGAR- 69 Query: 134 SREIVFTRNATEAINLVAYS--WGLSNLKPGDE-VILTVAEHHSCIVPWQIVSQKTGAVL 190 E++FT TE+ NL W + +P ++ T EHH+ + + + GA + Sbjct: 70 PSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHV 129 Query: 191 KFVTLNEDEVPDINKLRELIS--PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLV 248 ++ D LRE + LV+V +N + + LPI E+ V A + G + Sbjct: 130 TWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHS 189 Query: 249 DACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDV 308 DA Q+V + +D + + HK GP G+G L + D+ + P + GG D+ Sbjct: 190 DAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDV--TCVPLMHGGGQERDI 247 Query: 309 FLDHSTYAEPPSRFEAGTP----AIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEK 364 +GTP A+G A A AVD L + + L E Sbjct: 248 --------------RSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAE- 292 Query: 365 LSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHC----AQ 420 + DV + G + + F G L LD +G+ +G C AQ Sbjct: 293 ---IDDVCLNG--ADDPMRLAGNAHFTFRGCEGDALLMLLD-ANGIECSTGSACTAGVAQ 346 Query: 421 PLHRY--LGVN-----ASARASLYFYNTKDDVDAFIVAL 452 P H +GV+ S R SL + + DVDA + L Sbjct: 347 PSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVL 385 >3CAI-A nrPDB Length = 406 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 101/411 (24%), Positives = 174/411 (42%), Gaps = 43/411 (10%) Query: 62 RILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELA 121 R LH + G V+ D+ A P +V + + ++ G H + ++ + A Sbjct: 17 RGLHPSL-GDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTV-GAHPSARRSAAVLDAA 74 Query: 122 RKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQI 181 R+ VA +NA D +V + ++L+A + S G EVI++ + + I PW Sbjct: 75 REAVADLVNA-DPGGVVLGADRAVLLSLLAEA-SSSRAGLGYEVIVSRLDDEANIAPWLR 132 Query: 182 VSQKTGAVLKF--VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWA 239 + + GA +K+ V + E+P LIS T+LVAV+ S L + + Sbjct: 133 AAHRYGAKVKWAEVDIETGELPTWQ-WESLISKSTRLVAVNSASGTLGGVTDLRAMTKLV 191 Query: 240 HDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFL 299 HDVGA V+VD + P+ ++D+++ +AD + ++H GP ++ +++S Sbjct: 192 HDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAHAWGGPPIGAMVFRDPSVMNSFG--- 248 Query: 300 GGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIG------------- 346 + + YA P+R E G G + A+++YL+ + Sbjct: 249 ---------SVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLAV 299 Query: 347 -MPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLD 405 M Y + YL L SLP V + G RP + + SF V + + L Sbjct: 300 SMQSADAYLNRVFDYLMVSLRSLPLVMLIG-RPEAQI---PVVSFAVHKVPADRVVQRLA 355 Query: 406 QQHGVAIRSGHHCAQPLHRYLGVN---ASARASLYFYNTKDDVDAFIVALA 453 +AI + + LGVN + L Y+T +VD + ALA Sbjct: 356 DNGILAI---ANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVRALA 403 >4EB7-A nrPDB Length = 382 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 93/407 (22%), Positives = 167/407 (41%), Gaps = 50/407 (12%) Query: 73 LVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINAS 132 + Y D + +L+A+ Y N +H KA + + AR+KVA+ +N Sbjct: 1 MAYFDYTSAKPVDERILEAMLPYMTESFGNP-SSVHSYGFKAREAVQEAREKVAKLVNGG 59 Query: 133 DSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 +VFT ATEA NL + + N + G ++++ EH S I P + + QK G +++ Sbjct: 60 -GGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFL-QKQGFEVEY 117 Query: 193 VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQ 252 + + + D++ + + + T LV+V H +N + + P+EEI A + +DA Sbjct: 118 IPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVL-AGKAALHIDATA 176 Query: 253 SVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDH 312 SV + VDV+K+ AD L SS+ + GP G+G L+ + + P LGGG+ Sbjct: 177 SVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWIRKE-AKLQPVILGGGQ--------- 226 Query: 313 STYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIH-------EYEVEIGKYLYEKL 365 + +G+ + + G A + + + + K L Sbjct: 227 ------ENGLRSGSENVPSIVGFGKAAEITAMEWREEAERLRRLRDRIIDNVLKIEESYL 280 Query: 366 SSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCA----QP 421 + P+ R+ + + + LD G+ +G C+ QP Sbjct: 281 NGHPEKRL-----------PNNVNVRFSYIEGESIVLSLDMA-GIQASTGSACSSKTLQP 328 Query: 422 LHRYLG-------VNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 H + + + +L YNT +DVD + L + S Sbjct: 329 SHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERLRS 375 >5HH9-A nrPDB Length = 390 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 78/413 (18%), Positives = 153/413 (37%), Gaps = 48/413 (11%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R+ F L + ++ + + P V +A++ ++ N + + + Sbjct: 6 LRQQFD-LDPQ-----YLHFANFLLTSHPRPVREAIERLRVRFDRNPGEAVDWHREEIWK 59 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 + AR R+ A ++ T + T+ + + +G ++PG E++ + EH+S Sbjct: 60 YEDEARAWAGRYF-AVQPGQVALTGSTTDGLAAI---YGGLLVQPGKEILTSSHEHYSTY 115 Query: 177 VPWQIVSQKTGAVLKFVTL-------NEDEVPDINKLRELISPKTKLVAVHHVSNVLASS 229 + ++ G ++ L + DE+ ++ + I P+T+++ + V + Sbjct: 116 TTLEYRHKRMGTQVREFPLFKDPHRVSADEI--LSSIAAQIRPQTRVLGMTWVQSGSGVK 173 Query: 230 LPIEEIVVWAHDVGAK--------VLVDACQSVPHMVVDVQKLNADFLVASSHKM-CGPT 280 LPI EI ++ K +VD V + D+ +A +HK GP Sbjct: 174 LPIREIGKLVRELNQKRDEQDRIIYVVDGVHGFGVEDVSFADFDCDYFIAGTHKWLFGPR 233 Query: 281 GIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVD 340 G G + +S+ L +D F T P G A +ALG A + Sbjct: 234 GTGVIIARSEQLQEHLVPSIPTFSRADNF---GTLMTP-----GGYHAFEHRLALGTAFE 285 Query: 341 YLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDL 400 +G ++ ++ YL ++L P VR+ P E F VEG + Sbjct: 286 LHLQLGKAEVQARIHQLNAYLKQRLGEHPKVRLVTPTSPEL--SSGFTFFRVEGRDCEAV 343 Query: 401 ATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALA 453 A L ++ V R + N + ++D + LA Sbjct: 344 AKHLMAHRVIS----------DAVDRDVGPVVRLAPSLLNDEAEIDRVLEILA 386 >1QZ9-A nrPDB Length = 416 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 88/411 (21%), Positives = 150/411 (36%), Gaps = 43/411 (10%) Query: 62 RILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYY-EFYNSNVHRGIHYLSAKATDEFEL 120 + Q ++YLD + +P A L Q E + + + R + SA D E Sbjct: 18 PLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGLIRS--WNSAGWRDLSER 75 Query: 121 ARKKVARFINASDSREIVFTRNATEAINLV-AYSWGL---SNLKPGDEVILTVAEHHSCI 176 ++A I A D E+V T T +INL S L + P VI+T E + Sbjct: 76 LGNRLATLIGARD-GEVVVTD--TTSINLFKVLSAALRVQATRSPERRVIVT--ETSNFP 130 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 I + + TL + P +L + I T +V + HV+ ++ + Sbjct: 131 TDLYIAEGLADMLQQGYTLRLVDSP--EELPQAIDQDTAVVMLTHVNYKTGYMHDMQALT 188 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM--CGPTGIGFLYGKSDLLHS 294 +H+ GA + D S + VD+ + AD+ + ++K GP F++ L Sbjct: 189 ALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVWVSPQLCDL 248 Query: 295 MPPFLGGGEMISDVFLDHSTY--AEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHE 352 +P L G S F Y + +R+ GT I + +D + M + Sbjct: 249 VPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQTDMASLRR 308 Query: 353 YEVEIGKY---LYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLA---TFLDQ 406 + + L E+ + ++ + PR E RG+ SF HP A +D+ Sbjct: 309 KSLALTDLFIELVEQRCAAHELTLVTPR--EHAKRGSHVSFE----HPEGYAVIQALIDR 362 Query: 407 QHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVS 457 R +P G Y T +V + L + + Sbjct: 363 GVIGDYR------EPRIMRFGFTP-------LYTTFTEVWDAVQILGEILD 400 >3OP7-A nrPDB Length = 375 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 74/362 (20%), Positives = 129/362 (35%), Gaps = 62/362 (17%) Query: 113 KATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEH 172 + +K V++ +I+ T AT A LV YS ++PGD VI + Sbjct: 60 GWIEGSPAFKKSVSQLYTGVKPEQILQTNGATGANLLVLYSL----IEPGDHVISLYPTY 115 Query: 173 HSCIVPWQIVSQKTGAVLKFVTLNEDE--VPDINKLRELISPKTKLVAVHHVSNVLASSL 230 + + GA + + E+ +PD+ KLR+LI P TK++ +++ +N + + Sbjct: 116 QQLYD----IPKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICINNANNPTGAVM 171 Query: 231 P---IEEIVVWAHDVGAKVLVDAC-QSVPHMVVD--VQKLNADFLVASSHKMCGPTGIGF 284 +EE+V A +VGA +L D +S + V ++ + V S K GI Sbjct: 172 DRTYLEELVEIASEVGAYILSDEVYRSFSELDVPSIIEVYDKGIAVNSLSKTYSLPGIRI 231 Query: 285 LYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSG 344 + ++ ++D+ D+ Y I G D ++ Sbjct: 232 GWVAAN------------HQVTDILRDYRDYT---------------MICAGVFDDLVAQ 264 Query: 345 IGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGL----HPTDL 400 + + E L E L+ L P S R A+ S + + D Sbjct: 265 LALAHYQEILERNRHILEENLAILDQW--IEEEPLVSYIRPAVVSTSFVKIAVDMPMEDF 322 Query: 401 ATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFN 460 L Q+HGV + G+ + R + + I L F Sbjct: 323 CLQLLQEHGVLLVPGN--------RFERDGYVRLGFA-----CEQETLIKGLEKLSQFLR 369 Query: 461 SF 462 F Sbjct: 370 RF 371 >1M32-A nrPDB Length = 366 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 103/280 (36%), Gaps = 20/280 (7%) Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEV-ILTVAEHHSC 175 E R+++ AS+ V + + + + S L P D+V I++ + + Sbjct: 38 VVEQIRQQLTALATASEGYTSVLLQG---SGSYAVEAVLGSALGPQDKVLIVSNGAYGAR 94 Query: 176 IVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI--SPKTKLVAVHHVSNVLASSLPIE 233 +V + G E PD+ + ++ P +A+ H PI+ Sbjct: 95 MVEM---AGLMGIAHHAYDCGEVARPDVQAIDAILNADPTISHIAMVHSETTTGMLNPID 151 Query: 234 EIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLL 292 E+ AH G +VDA S + +D+ L+ D+L++S++K + G G F+ + L Sbjct: 152 EVGALAHRYGKTYIVDAMSSFGGIPMDIAALHIDYLISSANKCIQGVPGFAFVIAREQKL 211 Query: 293 HSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHE 352 + + RF + T + +A A+ L+ G Sbjct: 212 AACKGHSRSLSLDLYAQWRCMEDNHGKWRFTSPTHTV---LAFAQALKELAKEGGVAARH 268 Query: 353 YEVEIGKYLYEKLSSLPDVRIYGPRP--SESVHRGALCSF 390 +Y + S + +R G + +H + +F Sbjct: 269 -----QRYQQNQRSLVAGMRALGFNTLLDDELHSPIITAF 303 >1VJO-A nrPDB Length = 393 Score = 94.4 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 57/347 (16%), Positives = 124/347 (35%), Gaps = 25/347 (7%) Query: 116 DEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSC 175 + + + + I + T A+ + ++PGD V++ VA + Sbjct: 67 ALMDEIQSLLRYVWQTENPLTIAVSGTGTAAMEATIANA----VEPGDVVLIGVAGYFGN 122 Query: 176 IVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI-SPKTKLVAVHHVSNVLASSLPIEE 234 ++ + GA ++ ++ EV + +LR + + + ++A+ H + P+E Sbjct: 123 R--LVDMAGRYGADVRTISKPWGEVFSLEELRTALETHRPAILALVHAETSTGARQPLEG 180 Query: 235 IVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCG--PTGIGFLYGKSDLL 292 + + G +LVD S+ + + + D + S K G P F + Sbjct: 181 VGELCREFGTLLLVDTVTSLGGVPIFLDAWGVDLAYSCSQKGLGCSPGASPFTMSSRAIE 240 Query: 293 HSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHE 352 D+ L + R T I AL A+ ++ G+ + Sbjct: 241 KLQRRRTKVANWYLDMNLLGKYW--GSERVYHHTAPINLYYALREALRLIAQEGLANCWQ 298 Query: 353 YEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAI 412 + +YL+E+L + + ++ + +C +G+ +A L +H + + Sbjct: 299 RHQKNVEYLWERLEDI-GLSLHVEKEYRLPTLTTVC--IPDGVDGKAVARRLLNEHNIEV 355 Query: 413 RSGHHCAQPLHRYLGVNASA-RASLYFYNTKDD-VDAFIVALADTVS 457 G + R L +N++ + VD I AL + Sbjct: 356 GGG---------LGELAGKVWRVGLMGFNSRKESVDQLIPALEQVLR 393 >4Q6R-A nrPDB Length = 511 Score = 84.4 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 106/310 (34%), Gaps = 34/310 (10%) Query: 99 YNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSN 158 +++ +H I K E+ R + F DS V T TE+I + ++ Sbjct: 112 WSNPLHPDIFPGLRKIEA--EIVRIACSLFNGGPDSCGCV-TSGGTESILMACKAYRDLA 168 Query: 159 LKPG---DEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK 215 + G E++ + H + + G + V L + D+ +R IS T Sbjct: 169 FEKGIKTPEIVAPQSAHAAF----NKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTA 224 Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC---------QSVPH---MVVDVQK 263 ++ P+ E+ A + VDAC + + D + Sbjct: 225 MLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRV 284 Query: 264 LNADFLVASSHKM-CGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRF 322 + A +HK P G + + + D YA P Sbjct: 285 KGVTSISADTHKYGYAPKGSSLVLYSDKKYRNY-------QFFVDTDWQGGIYASPTI-- 335 Query: 323 EAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESV 382 AG+ G + A AA+ + G + + ++ ++L +L ++ + ++G P SV Sbjct: 336 -AGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGN-PQLSV 393 Query: 383 HRGALCSFNV 392 F++ Sbjct: 394 IALGSRDFDI 403 >2DR1-A nrPDB Length = 386 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 56/380 (14%), Positives = 122/380 (32%), Gaps = 45/380 (11%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 VL+ ++ + S +R +H D E R+ F+ ++ + T Sbjct: 33 PEVLEIMKVQMFSHRSKEYRKVHM------DTVERLRE----FLEVEKGEVLLVPSSGTG 82 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINK 205 + + + + G +V++T+ + ++ V + G + + Sbjct: 83 ----IMEASIRNGVSKGGKVLVTII--GAFGKRYKEVVESNGRKAVVLEYEPGKAVKPED 136 Query: 206 LRELIS--PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQK 263 L + + P + V + + P+ E+ A + V VDA ++ + K Sbjct: 137 LDDALRKNPDVEAVTITYNETSTGVLNPLPELAKVAKEHDKLVFVDAVSAMGGADIKFDK 196 Query: 264 LNADFLVASSHKMCG-PTGIGFLYGKSDLLH-SMPPFLGGGEMISDVFLDHSTYAEPPSR 321 D + +SS K G P G+ L + G + D Y + Sbjct: 197 WGLDVVFSSSQKAFGVPPGLAIGAFSERFLEIAEKMPERGW------YFDIPLYVKYLKE 250 Query: 322 FE--AGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYG-PRP 378 E TP + + + A+ + +G E + Y VR G Sbjct: 251 KESTPSTPPMPQVFGINVALRIIEKMG-----GKEKWLEMYEKRAKMVREGVREIGLDIL 305 Query: 379 SESVHRGALCS--FNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARASL 436 +E H + G+ ++ + ++ G + G+ + + R Sbjct: 306 AEPGHESPTITAVLTPPGIKGDEVYEAM-RKRGFELAKGYGSVK--------EKTFRIGH 356 Query: 437 YFYNTKDDVDAFIVALADTV 456 Y +D+ + L + + Sbjct: 357 MGYMKFEDIQEMLDNLREVI 376 >3MAF-B nrPDB Length = 518 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 98/291 (33%), Gaps = 36/291 (12%) Query: 107 IHYLSAKATDEFE-LARKKVARFINASDSREIV---FTRNATEAINLVAYSWGL-SNLKP 161 +H +T +FE A + + V T TE++ L ++ + Sbjct: 133 LHPDLWPSTAKFEAEVVAMTAHMLGGDAAGGTVCGTVTSGGTESLLLAMKTYRDWARATK 192 Query: 162 G---DEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVA 218 G E ++ V+ H + +Q G L L+ D D+ +RE I+P T +VA Sbjct: 193 GITAPEAVVPVSAHAAF----DKAAQYFGIKLVRTPLDADYRADVAAMREAITPNTVVVA 248 Query: 219 VHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC-----------QSVPHMVVDVQKLNAD 267 PI EI A + G VDAC P D + Sbjct: 249 GSAPGYPHGVVDPIPEIAALAAEHGIGCHVDACLGGFILPWAERLGYPVPPFDFRLEGVT 308 Query: 268 FLVASSHKM-CGPTGIGF-LYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAG 325 + A +HK G G LY + DLLH + Y P AG Sbjct: 309 SVSADTHKYGYGAKGTSVILYRRPDLLH--------YQYFIAADWPGGLYFSPTF---AG 357 Query: 326 TPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGP 376 + + AA+ L G ++ L + ++P ++I G Sbjct: 358 SRPGALSATAWAAMLSLGEEGYLDATRRILQAADRLKAGVRAIPSLKILGD 408 >3KGX-A nrPDB Length = 393 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 51/350 (14%), Positives = 120/350 (34%), Gaps = 29/350 (8%) Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 E ++ + + +V + + + + + L+PGD + Sbjct: 57 IMEEIKQGIQYVFQTRNPLTLVVSGSG----HCAMETALFNLLEPGDSFLTGTN------ 106 Query: 177 VPWQI----VSQKTGAVLKFVTLNEDEVPDINKLRELISP-KTKLVAVHHVSNVLASSLP 231 W + ++ + GA + + E + ++ E ++ K L+ + H + P Sbjct: 107 GIWGMRAAEIADRIGARVHQMIKKPGEHYTLQEVEEGLAQHKPVLLFLVHGESSTGVVQP 166 Query: 232 IEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMC-GPTGIGFL-YGKS 289 ++ H +LVD+ S+ + + + + D + +SS K+ P GI + + Sbjct: 167 LDGFGELCHRYQCLLLVDSVASLGGVPIYMDQQGIDIMYSSSQKVLNAPPGISLISFNDK 226 Query: 290 DLLHSMPPFLGGGEMISDVFLDHSTYA-EPPSRFEAGTPAIGEAIALGAAVDYLSGIGMP 348 +D+ + E +R T + L ++ ++ G+ Sbjct: 227 AKYKVYSRKTKPVSFYTDITYLAKLWGCEGETRVIHHTTPVTSLYCLRESLALIAEQGLE 286 Query: 349 KIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQH 408 E +L++ L ++ + P + + G + D+ +++ Sbjct: 287 NCWRRHREATAHLHKHL-QEMGLKFFVKDPEIRLPTITTVT-VPAGYNWRDIVSYVLDHF 344 Query: 409 GVAIRSGHHCAQPLHRYLGVNASARASLYFYN-TKDDVDAFIVALADTVS 457 + I G P + R L YN T ++VD AL + + Sbjct: 345 SIEISGG---LGPTEERV-----LRIGLLGYNATTENVDRVAEALREALQ 386 >2YRI-A nrPDB Length = 353 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 61/338 (18%), Positives = 110/338 (32%), Gaps = 34/338 (10%) Query: 82 SQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTR 141 + P V AL + + + + +++A D E Sbjct: 9 TPIPERVQKALLRPMRGH-------LDPEVLRVNRAIQ---ERLAALF---DPGEGALVA 55 Query: 142 NATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVP 201 + +L + GL+NL G V++ V S V + E P Sbjct: 56 ALAGSGSLGMEA-GLANLDRGP-VLVLVNGAFSQRVAEMAALHGLDPEVLDFPPGEPVDP 113 Query: 202 DINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDV 261 + R L + ++VA+ H P E I A + GA +DA ++ + + Sbjct: 114 EAVA-RALKRRRYRMVALVHGETSTGVLNPAEAIGALAKEAGALFFLDAVTTLGMLPFSM 172 Query: 262 QKLNADFLVASSHK-MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPS 320 + + D+ S K + P G+ + + + G ++ V Sbjct: 173 RAMGVDYAFTGSQKCLSAPPGLAPIAASLEARKAFTGKRGWYLDLARV---------AEH 223 Query: 321 RFEAGTPAIGEAI---ALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPR 377 G + AL A+D + G+ E+ ++ E+L + R + P Sbjct: 224 WERGGYHHTTPVLLHYALLEALDLVLEEGVAARERRAREVYAWVLEELKA----RGFRPY 279 Query: 378 PSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSG 415 P S L EG+ L L + GVA+ G Sbjct: 280 PKASPLPTVLVVRPPEGVDADRLVRALYAE-GVAVAGG 316 >3E9K-A nrPDB Length = 465 Score = 78.6 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 70/407 (17%), Positives = 134/407 (32%), Gaps = 39/407 (9%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASD 133 +Y + +P V L+ + + + + H + + + + + + I ++ Sbjct: 69 IYFLGNSLGLQPKMVKTYLEEELDKW-AKIAAYGHEVGKRPWITGDESIVGLMKDIVGAN 127 Query: 134 SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVA---EHHSCIVPWQIVSQKTGAVL 190 +EI T ++L+ S+ K ++ A +H++ Q+ + Sbjct: 128 EKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESM 187 Query: 191 KFV-TLNEDEVPDINKLRELISPKTKLVAVHHVSNV---LASSLPIEEIVVWAHDVGAKV 246 + + +E I + E+I + +AV S V I I G V Sbjct: 188 RMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYV 247 Query: 247 LVDACQSVPHMVVDVQKLNADFLVASSHKMCG--PTGIGFLYGKSDLLHSMPPFLGGGEM 304 D +V ++ + + DF S+K GI + H++ P L G Sbjct: 248 GFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFG 307 Query: 305 I--SDVFLDHSTYAEPPS--RFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKY 360 S F + P F P I +L A+++ M + + V + Y Sbjct: 308 HELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGY 367 Query: 361 LY----------EKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGV 410 L + + P V I P E +F+V D+ L+++ V Sbjct: 368 LEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSV---PNKDVFQELEKRGVV 424 Query: 411 AIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVS 457 C + N A + YN+ DV F L + Sbjct: 425 -------CDKR-----NPNGIRVAPVPLYNSFHDVYKFTNLLTSILD 459 >3ISL-A nrPDB Length = 416 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 96/285 (33%), Gaps = 26/285 (9%) Query: 151 AYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI 210 + S ++P D+V++ + ++ ++++ GA + + V D + I Sbjct: 75 IEAVLASVIEPEDDVLIPIYGRFGYLLT--EIAERYGANVHMLECEWGTVFDPEDIIREI 132 Query: 211 SP-KTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFL 269 K K+VA+ H P++ I A +VDA ++ V V + D Sbjct: 133 KKVKPKIVAMVHGETSTGRIHPLKAIGEACRTEDALFIVDAVATIGGCEVKVDEWKIDAA 192 Query: 270 VASSHKMCG-PTGIG----------FLYGKSDL-----LHSMPPFLGGGEMISDVFLDHS 313 + + K P+G+ + + + + L G I+ + D S Sbjct: 193 IGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGNRPITSNYFDLS 252 Query: 314 TYAE--PPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDV 371 + R T A AL V + G+ E L + + Sbjct: 253 QLEDYWSERRLNHHTEATTMLYALREGVRLVLEEGLETRFERHRHHEAALAAGI-KAMGL 311 Query: 372 RIYGPRPSESVHRGALCSFNV-EGLHPTDLATFLDQQHGVAIRSG 415 R++G +S + + G+ + L Q G+ I S Sbjct: 312 RLFG---DDSCKMPVVTCVEIPGGIDGESVRDMLLAQFGIEIASS 353 >2Z9W-A nrPDB Length = 392 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 85/240 (35%), Gaps = 10/240 (4%) Query: 181 IVSQKTGAVLKFVTLNEDEVPDINKLRELIS--PKTKLVAVHHVSNVLASSLPIEEIVVW 238 +++ L + + +E D + +++ P+ +V+V H + PI+ I Sbjct: 100 YWAKRYSPHLLEIEVPYNEAIDPQAVADMLKAHPEITVVSVCHHDTPSGTINPIDAIGAL 159 Query: 239 AHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCG-PTGIGFLYGKSDLLHSM-- 295 GA ++VDA S M + AD V +K G P G+ + M Sbjct: 160 VSAHGAYLIVDAVSSFGGMKTHPEDCKADIYVTGPNKCLGAPPGLTMMGVSERAWAKMKA 219 Query: 296 PPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEV 355 P M+S V +++ + P F TP++ E L A+D G + Sbjct: 220 NPLAPRASMLSIVDWENAWSRDKPFPF---TPSVSEINGLDVALDLYLNEGPEAVWAR-H 275 Query: 356 EIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSG 415 + + + ++ S + +G+ L ++GV SG Sbjct: 276 ALTAKAMRAGVTAMGLSVWAASDSIASPTTTAVR-TPDGVDEKALRQAARARYGVVFSSG 334 >2BKW-A nrPDB Length = 385 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 101/298 (33%), Gaps = 19/298 (6%) Query: 131 ASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVL 190 AS S+ V + T ++ A ++ LS + ++++ GA + Sbjct: 56 ASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLR---SYGAQV 112 Query: 191 KFV-TLNEDEVPDINKLRELISPKTK-LVAVHHVSNVLASSLPIEEIVVWAHDV--GAKV 246 V L E + + E +S + V V HV A ++ I Sbjct: 113 DVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFF 172 Query: 247 LVDACQSVPHMVVDVQKLNADF-LVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMI 305 +VDA S+ + + DF L AS + P G+ S + + Sbjct: 173 VVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSRFMD-YALNDSKNGHV 231 Query: 306 SDVFLDHSTYAEPPSRFEAG------TPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGK 359 F + +EAG TP + +L A+ + G+ K + E+ Sbjct: 232 HGYFSSLRRWTPIMENYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSD 291 Query: 360 YLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHH 417 + + L + + PS G + + P D+ FL + HGV I G H Sbjct: 292 WFKDSLVNGLQLTSVSRYPSNMSAHGLTAVYVAD---PPDVIAFL-KSHGVVIAGGIH 345 >5V1X-E nrPDB Length = 501 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 125/347 (36%), Gaps = 31/347 (8%) Query: 76 LDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSR 135 L+ + P+A+ L++Y + +L + + +R VA + Sbjct: 50 LNHGSFGTIPSAIQQKLRSYQTAAEARPCP---FLRYQTPVLLDESRAAVANLLK-VPVE 105 Query: 136 EIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLK---- 191 +VF NAT +N V + S DE++ +C V + ++ Sbjct: 106 TVVFVANATMGVNTVLRNIVWSADGK-DEILYFDTIFGACGKTIDYVIEDKRGIVSSRCI 164 Query: 192 --FVTLNEDEVPDINKLRELISP------KTKLVAVHHVSNVLASSLPIEEIVVWAHDVG 243 +D+V + R+ I + +L + VS++ P E+IV + Sbjct: 165 PLIYPAEDDDV--VAAFRDAIKKSREEGKRPRLAVIDVVSSMPGVRFPFEDIVKICKEEE 222 Query: 244 AKVLVDACQSVPHMVVDVQKLNADFLVASSHKM-CGPTGIGFLYG---KSDLLHSMPPFL 299 VD Q + + + + + + DFL+++ HK P G Y L+ S P Sbjct: 223 IISCVDGAQGIGMVDLKITETDPDFLISNCHKWLFTPRGCAVFYVPVRNQHLIRSTLPTS 282 Query: 300 GG-----GEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGI--GMPKIHE 352 G G + + + A + GT + A+ + + G +I E Sbjct: 283 HGFVPQVGNRFNPLVPAGNKSAFVSNFEFVGTVDNSPFFCVKDAIKWREEVLGGEERIME 342 Query: 353 YEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTD 399 Y ++ + +K++ + R+ + R A+ + + + D Sbjct: 343 YMTKLAREGGQKVAEILGTRVLENSTGTLI-RCAMVNIALPFVVGED 388 >5LUC-A nrPDB Length = 403 Score = 69.0 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 51/361 (14%), Positives = 126/361 (34%), Gaps = 35/361 (9%) Query: 109 YLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILT 168 +S + ++ + + +V + + + + ++ L+PGD ++ Sbjct: 59 SMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSG----HCALEAALVNVLEPGDSFLVG 114 Query: 169 VAEHHSCIVPWQIVS---QKTGAVLKFVTLNEDEVPDINKLRELISP-KTKLVAVHHVSN 224 + + Q ++ GA + +T + + ++ E ++ K L+ + H + Sbjct: 115 -----ANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGES 169 Query: 225 VLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK-MCGPTGIG 283 P++ H +LV++ S+ + + + D L + S K + P G Sbjct: 170 STGVLQPLDGFGELCHRYKCLLLVNSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTS 229 Query: 284 FLY----GKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAV 339 + K + + +L + + R T + +L ++ Sbjct: 230 LISFSDKAKKKMYSRKTKPFS--FYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESL 287 Query: 340 DYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTD 399 ++ G+ E YL+ +L +L ++++ P+ + + G D Sbjct: 288 ALIAEQGLENSWRQHREAAAYLHGRLQAL-GLQLFVKDPALRLPTVTTVA-VPAGYDWRD 345 Query: 400 LATFLDQQHGVAIRSGHHCAQPLHRYLGVNA--SARASLYFYN-TKDDVDAFIVALADTV 456 + +++ + I G LG + R L N T+++VD AL + Sbjct: 346 IVSYVIDHFDIEIMGG----------LGPSTGKVLRIGLLGCNATRENVDRVTEALRAAL 395 Query: 457 S 457 Sbjct: 396 Q 396 >3ZRR-A nrPDB Length = 384 Score = 67.9 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 63/355 (17%), Positives = 119/355 (33%), Gaps = 31/355 (8%) Query: 111 SAKATDEFELARKKVARFINASDSRE-IVFTRNATEAINLVAYSWGLSNLKPGDEVILTV 169 S + + + K + + AS + + ++ T A+ V S LKP D++++ Sbjct: 30 SKEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTSAMESV-----TSLLKPNDKILV-- 82 Query: 170 AEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKT-KLVAVHHVSNVLAS 228 + W+ + ++ +K + + + ++ E + KLVA+ HV Sbjct: 83 VSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGV 142 Query: 229 SLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGK 288 P+++++ ++VD SV V ++ N D + +S K G G Sbjct: 143 REPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKA---LGSAAGLGL 199 Query: 289 SDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAG------TPAIGEAIALGAAVDYL 342 L L I+ +LD + E G TP + + L A + Sbjct: 200 LLLSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLI 259 Query: 343 SGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLAT 402 G+ + + + L +L + I RP + V T Sbjct: 260 EKEGIENRIKRHTMVASAIRAGLEAL-GLEIVARRPESYSNTVTGVILKVADPQKVLAGT 318 Query: 403 FLDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVS 457 GV G H P +Y R + T +D I + T+ Sbjct: 319 V---NEGVEFAPGVH---PAFKYF------RIGHMGWVTPNDAIIAISVIERTLR 361 >3NNK-A nrPDB Length = 411 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 48/327 (14%), Positives = 108/327 (33%), Gaps = 31/327 (9%) Query: 151 AYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI 210 + +S ++PGD+V++ V + ++++ A + + + EV +++ + + Sbjct: 77 IEAILVSAIRPGDKVLVPVFGRFGHL--LCEIARRCRAEVHTIEVPWGEVFTPDQVEDAV 134 Query: 211 -SPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFL 269 + +L+ P+ E+ A DA S+ ++ D + Sbjct: 135 KRIRPRLLLTVQGDTSTTMLQPLAELGEICRRYDALFYTDATASLGGNPLETDVWGLDAV 194 Query: 270 VASSHK-MCGPTGIGFLYGKSDLLHSMPPFL-------------GGGEMISDVFLDHSTY 315 A K + GP+G + + + ++ G EMI + D Sbjct: 195 SAGMQKCLGGPSGTSPITLSARMEEAIRRRKCVEEGIRTDAHRDGDEEMIYSNYFDLGMV 254 Query: 316 AE--PPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRI 373 + P R T A + G+ G L + + + Sbjct: 255 MDYWGPERLNHHTEATTALFGARECARLILQEGLDYGIARHKLHGDALVKGI-QAMGLET 313 Query: 374 YGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASAR 433 +G + + + +G++ + + G+ I + PLH + R Sbjct: 314 FGDLKHKMNNVLGVV--IPQGINGDQARKLMLEDFGIEIGTSFG---PLHGKV-----WR 363 Query: 434 ASLYFYNTKDD-VDAFIVALADTVSFF 459 YN + D V + AL +++ Sbjct: 364 IGTMGYNARKDCVMTTLSALEAVLNYL 390 >1XI9-A nrPDB Length = 406 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 54/259 (20%), Positives = 102/259 (39%), Gaps = 32/259 (12%) Query: 130 NASD--SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTG 187 N D ++ T TEA+ L+ + L PGDE+++ + P+ + + G Sbjct: 95 NGVDITPDDVRVTAAVTEALQLIF----GALLDPGDEILVPGPSYP----PYTGLVKFYG 146 Query: 188 AV-LKFVTLNEDE-VPDINKLRELISPKTKLVAVHHVSNVLASSLP---IEEIVVWAHDV 242 +++ T+ E++ PDI+ +R+ I+ +TK +AV + +N + +EEI+ A + Sbjct: 147 GKPVEYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALYDKKTLEEILNIAGEY 206 Query: 243 GAKVLVDACQSVPHMV---VDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFL 299 V+ D + + L D V + G+ +Y + F+ Sbjct: 207 EIPVISDEIYDLMTYEGEHISPGSLTKDVPVIVMN------GLSKVYFATGWRLGYMYFV 260 Query: 300 GGGEMISDVFLDHSTYAEPPSRFEAGTPA-IGEAIALGAAVDYLSGIGMPKIHEYEVEIG 358 +S+V A R TPA L +DYL Sbjct: 261 DPENKLSEVREAIDRLARI--RLCPNTPAQFAAIAGLTGPMDYLKEYMKKLKERR----- 313 Query: 359 KYLYEKLSSLPDVRIYGPR 377 Y+Y++L+ +P + P+ Sbjct: 314 DYIYKRLNEIPGISTTKPQ 332 >2E7J-A nrPDB Length = 371 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 88/261 (33%), Gaps = 38/261 (14%) Query: 123 KKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIV 182 ++ +F+ +R T A EA V +S K V++ H+S V Sbjct: 61 NQLPKFLGCDVAR---VTNGAREAKFAVMHSLA----KKDAWVVMDENCHYSSYV----A 109 Query: 183 SQKTGAVLKFVTLNE--DEVPDINKLRELISPKTK-----LVAVHHVSNVLASSLPIEEI 235 +++ G + V + D + I K L + + + +++I Sbjct: 110 AERAGLNIALVPKTDYPDYAITPENFAQTIEETKKRGEVVLALITYPDGNYGNLPDVKKI 169 Query: 236 VVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTG-IGFLYGKSDLLHS 294 + +LV+ ++ M V ++++ ADF+V S HK +G IG + K + Sbjct: 170 AKVCSEYDVPLLVNGAYAIGRMPVSLKEIGADFIVGSGHKSMAASGPIGVMGMKEEWAEI 229 Query: 295 MPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYL------SGIGMP 348 V Y T I L A+ ++ + Sbjct: 230 -------------VLRRSEKYKNKEVELLGCTARGATIITLMASFPHVRERIKRWDEEVE 276 Query: 349 KIHEYEVEIGKYLYEKLSSLP 369 K + E+ K ++L P Sbjct: 277 KARRFAAEMEKLGIKQLGDNP 297 >5DX5-A nrPDB Length = 400 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 67/376 (17%), Positives = 119/376 (31%), Gaps = 51/376 (13%) Query: 105 RGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDE 164 + S K+A V + AI +S LK GD Sbjct: 53 ESGYIYSRLGNPTSTEVENKLALLEGG---EAAVVAASGMGAIAASLWSA----LKSGDH 105 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSN 224 V+ + + + G + FV ++ ++++++ + P TK+V + +N Sbjct: 106 VVASDTLYGCTFALLNHGLTRYGVEVTFVDVS-----NLDEVKNALKPNTKVVYLETPAN 160 Query: 225 VLASSLPIEEIVVWAHDVGA--KVLVDACQSVPHMVVDVQKLNADFLVASSHKM---CGP 279 I +I H+ V VD P++ ++ L AD +V S+ K G Sbjct: 161 PTLKVTDIRKISNMVHESNKECFVFVDNTFCTPYIQRPLE-LGADVVVHSATKYLNGHGD 219 Query: 280 TGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAV 339 GF GK + ++ + F + + P F I L + Sbjct: 220 VIAGFAVGKEEFINQVKLF--------GIKDMTGSVTGPFESFL----IIRGMKTLQLRM 267 Query: 340 DYLSGIGMPKIHEYEVE--IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNV-EGLH 396 + M E + K Y L S + Y + GA+ SF + G+ Sbjct: 268 EKHCKNAMEVAKFLESHPAVEKVYYPGLES---FKYYQLAREQMKLPGAMISFELKGGVE 324 Query: 397 PTDLATFLDQQHGVAIRSG------HHCAQPLHRYLGV---------NASARASLYFYNT 441 + + +A+ G H A H + R S+ + Sbjct: 325 EGKIVMNNVKLATLAVSLGDSETLIQHPASMTHSPYTAEERKAAGISDGLVRLSVGLEDA 384 Query: 442 KDDVDAFIVALADTVS 457 +D +D AL V Sbjct: 385 EDIIDDLKQALDLIVK 400 >3F9T-A nrPDB Length = 397 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 58/362 (16%), Positives = 110/362 (30%), Gaps = 48/362 (13%) Query: 113 KATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEH 172 E A + +N D+ + TEA + + + + + EH Sbjct: 66 GTKLLEEKAVALLGSLLNNKDAYGHI-VSGGTEANLMALRCIKNIWREKRRKGL-SKNEH 123 Query: 173 HSCIVP------WQIVSQKTGAVLKFVTLNEDEVPDINKLRELISP-KTKLVAVHHVSNV 225 IVP ++ + + + ED D +++ + + + Sbjct: 124 PKIIVPITAHFSFEKGREMMDLEYIYAPIKEDYTIDEKFVKDAVEDYDVDGIIGIAGTTE 183 Query: 226 LASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASS--HKMCGPTGIG 283 L + IEE+ A + + VDA + +V+ D +K G+ Sbjct: 184 LGTIDNIEELSKIAKENNIYIHVDA--AFGGLVIPFLD---DKYKKKGVNYKFDFSLGVD 238 Query: 284 FLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAI-GEAIALGAA---- 338 + + P GG + D+ + P E I G + G A Sbjct: 239 SITIDPHKMGHCPIP-SGGILFKDIGYKRYLDVDAPYLTETRQATILGTRVGFGGACTYA 297 Query: 339 -VDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHP 397 + YL G KI +E YLY+KL + P N+ + Sbjct: 298 VLRYLGREGQRKIVNECMENTLYLYKKLKENNFKPVIEPI------------LNIVAIED 345 Query: 398 TDLATFLD--QQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 455 D + G+ + +C + + R + + ++ +D FI L Sbjct: 346 EDYKEVCKKLRDRGIYVSV-CNCVK----------ALRIVVMPHIKREHIDNFIEILNSI 394 Query: 456 VS 457 Sbjct: 395 KR 396 >3WKR-A nrPDB Length = 416 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 41/196 (20%), Positives = 82/196 (41%), Gaps = 20/196 (10%) Query: 90 DALQNYYEFYNS-NVHRGIHYLSAKAT-DEFELARKKVARFIN---ASDSREIVFTRNAT 144 +A + YE+++ +V H + T + + +A+F+N A T A Sbjct: 69 EAKKAVYEYWDGYSVCDYCHGRLDEVTCPPIKDFLEDIAKFLNMDCARP------THGAR 122 Query: 145 EAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIV---SQKTGAVLKF--VTLNEDE 199 E +V ++ K GD V+L H++ V + + G ++ +N + Sbjct: 123 EGKFIVMHAIC----KEGDYVVLDKNAHYTSYVAAERAKLNVAEVGYEEEYPTYKINLEG 178 Query: 200 VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVV 259 ++ E L+ + HV + +++ A + G L++ +V M V Sbjct: 179 YKEVIDNLEDKGKNVGLILLTHVDGEYGNLNDAKKVGKIAKEKGIPFLLNCAYTVGRMPV 238 Query: 260 DVQKLNADFLVASSHK 275 + +++ ADF+VAS HK Sbjct: 239 NGKEVKADFIVASGHK 254 >2CH1-A nrPDB Length = 396 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 47/255 (18%), Positives = 94/255 (36%), Gaps = 12/255 (4%) Query: 140 TRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE 199 T + + + + + L+ GD V++ V + +S++ GA ++ + D Sbjct: 71 TMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERA--VEMSERYGADVRTIEGPPDR 128 Query: 200 VPDINKLRELIS-PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMV 258 + L I + K + + H + P+E + H ++VDA S+ + Sbjct: 129 PFSLETLARAIELHQPKCLFLTHGDSSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGVP 188 Query: 259 VDVQKLNADFLVASSHKMCG-PTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTY-- 315 + K D + + K+ G P GI + L + ++ L Y Sbjct: 189 FYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYWG 248 Query: 316 -AEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIY 374 + P R+ T A AL A+ ++ G+ + +E + LYE L + I+ Sbjct: 249 CYDEPKRYHH-TVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGK-MGLDIF 306 Query: 375 GPRPSESVHRGALCS 389 + HR + Sbjct: 307 ---VKDPRHRLPTVT 318 >4BMK-A nrPDB Length = 442 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 65/380 (17%), Positives = 111/380 (29%), Gaps = 57/380 (15%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNAT 144 V+ A + E + S + D E + + F + IVF+ Sbjct: 102 DPDVIAAGKEALEKFGSGTNGSRMLNGT-FHDHME-VEQALRDFYGTT--GAIVFSTGY- 156 Query: 145 EAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDIN 204 + + G+ VIL H S Q+ A + N E D Sbjct: 157 ----MANLGIISTLAGKGEYVILDADSHASIYDG----CQQGNAEIVRFRHNSVEDLD-K 207 Query: 205 KLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKL 264 +L L KLV + V ++L P++E+V A GA VLVD S+ Sbjct: 208 RLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKKHGAMVLVDEAHSMG--------- 258 Query: 265 NADFLVASSHKMCGPTGIGFLYGK---SDLLHSMPPF------LGGGEMISDVFLDHSTY 315 GP G G + + + F +GG + + + Sbjct: 259 -----------FFGPNGRGVYEAQGLEGQIDFVVGTFSASVGTVGGFVVSNHPKFEAVRL 307 Query: 316 AEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYG 375 A P F A P A A + K+ + + + ++ G Sbjct: 308 ACRPYIFTASLPPSVVATA---------TTSIRKLMTAHEKRERLWSNARALHGGLKAMG 358 Query: 376 PRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRYLGVNASARAS 435 R A+ + +E + G+ + A P +L R S Sbjct: 359 FRLGTETCDSAIVAVMLEDQEQAAMMWQALLDGGLYVNMARPPATPAGTFL-----LRCS 413 Query: 436 LYFYNTKDDVDAFIVALADT 455 + +T + + Sbjct: 414 ICAEHTPAQIQTVLGMFQAA 433 >5K1R-A nrPDB Length = 480 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 40/260 (15%), Positives = 85/260 (32%), Gaps = 48/260 (18%) Query: 142 NATEAI-NLVAYSWGLSNLKPGDE---VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNE 197 TE+I N + + G E +I + H + + G + ++ Sbjct: 125 GGTESILNATLAYREKARAERGIERPRMIWPASAHPAFR----KAAHLFGFDVTVAPIDP 180 Query: 198 DEV-PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC----- 251 + D + +R+ + T ++ + + PI + A + + VD C Sbjct: 181 VTMQVDADFVRDAVDANTVMLVGSACNYPYGTIDPIGALSAIAVEKDVWLHVDGCLGGWM 240 Query: 252 ----QSVPHMVV---DVQKLNADFLVASSHKM-CGPTGIGFL-YG----KSDLLHSMPPF 298 +++ + + D + + A +HK GP G L + + M + Sbjct: 241 LPWGEALGYPDIPAFDFRLPGVTSISADTHKFGYGPKGGSVLAWRDASFRRHQYFLMTDW 300 Query: 299 LGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIG 358 +GG + S G IA A L +G I Sbjct: 301 VGGVYGSPGLTGSRS----------------GGLIAATWAA--LRSLGREGYLARAKAIF 342 Query: 359 KYLYE---KLSSLPDVRIYG 375 + ++ + ++P++R+ G Sbjct: 343 ETAFDMQAAVRAIPELRVLG 362 >4W8I-A nrPDB Length = 551 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 102/306 (33%), Gaps = 30/306 (9%) Query: 77 DSAAT-SQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSR 135 DS A + P + + L+ Y + + +H + + + S Sbjct: 101 DSGALYAIHPKELTELLKEVY--GATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSKEG 158 Query: 136 EIVFTRNATEAINLVAYSWGLSNLKPG---DEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 + T T +I ++ + G E+++ H + + ++ TGA+L Sbjct: 159 YGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAF----KKAAELTGAILIT 214 Query: 193 VTLNE-DEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 V +++ + N + I+ T ++ S + PI E+ A VDAC Sbjct: 215 VPVDKKTGAVNPNVMSSYITRNTAVMVGSAPSFMNGIHDPISELGQLAKKKNVPFHVDAC 274 Query: 252 QS--------VPHMVVDVQKLNADFLVASSHKM-CGPTGIGFLYGKSDLLHSMPPFLGGG 302 +D + + A HK C P G D P L Sbjct: 275 LGGFLTAFLDTSSEPMDFRVPGVTSISADLHKYGCCPKGTSVCLFSED-----SPALS-- 327 Query: 303 EMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLY 362 + + + YA P G+ + + A + Y +I + + + + Sbjct: 328 -VYAALNWSGGLYATP--GILDGSTSGARVAEVYATLSYYGKNKYQEIAKSIIRLRNAIQ 384 Query: 363 EKLSSL 368 ++L++L Sbjct: 385 KELTAL 390 >1V2E-A nrPDB Length = 381 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 60/390 (15%), Positives = 127/390 (32%), Gaps = 71/390 (18%) Query: 81 TSQKPAAVLDALQNYYEFY--NSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIV 138 ++ P +L+A++ + R+ +A A + +V Sbjct: 36 SNPPPPFLLEAVRRALGRQDQYAPP------------AGLPALREALAEEF-AVEPESVV 82 Query: 139 FTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNED 198 T ATEA+ ++ S + PGDEV++ +P ++ A L + L + Sbjct: 83 VTSGATEALYVLLQSL----VGPGDEVVVLEPFFD-VYLPDAFLAGAK-ARLVRLDLTPE 136 Query: 199 EV-PDINKLRELISPKTKLVAVHHVSNVLASSL---PIEEIVVWAHDVGAKVLVDACQS- 253 D++ L + ++P+T+ + ++ N +E I A ++ D Sbjct: 137 GFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDE 196 Query: 254 --VPHMVVDVQKLNAD--FLVASSHKMCGPTG--IGFLYGKSDLLHSMPPFLGGGEMISD 307 +++ + F V S+ K TG +G++ G + + + Sbjct: 197 LYYGERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRL------------ 244 Query: 308 VFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSS 367 + T P+ +AG + EA+ L + + L L + Sbjct: 245 AGMRQWTSFSAPTPLQAG---VAEALKLARREGFYEALREGYRRRR-----DLLAGGLRA 296 Query: 368 LPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGH-HCAQPLHRYL 426 +R+Y P F + L D +++ I + + P Sbjct: 297 -MGLRVYVPEG---------TYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLF 346 Query: 427 GVNASARASLYFYNTKDDVDAFIVALADTV 456 F T++++ + L V Sbjct: 347 --------RFAFCKTEEELHLALERLGRVV 368 >3VK2-A nrPDB Length = 398 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 68/192 (35%), Gaps = 16/192 (8%) Query: 108 HYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVIL 167 H+ S + L ++A + A + L+PGDEV+L Sbjct: 57 HFYSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTL-------LRPGDEVLL 109 Query: 168 TVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLA 227 + + G L+ V + D+ L ++P T+++ +N Sbjct: 110 GNTLYGHTFAFLHHGIGEFGVKLRHVDMA-----DLQALEAAMTPATRVIYFESPANPNM 164 Query: 228 SSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM---CGPTGIGF 284 I + A GA V+VD P++ ++ L AD +V S+ K G G Sbjct: 165 HMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLE-LGADLVVHSATKYLSGHGDITAGI 223 Query: 285 LYGKSDLLHSMP 296 + G L+ + Sbjct: 224 VVGSQALVDRIR 235 >3NYS-A nrPDB Length = 367 Score = 59.8 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 38/178 (21%), Positives = 68/178 (38%), Gaps = 25/178 (14%) Query: 79 AATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIV 138 ++ + +Q G + L + T+ + ++A F+ A + Sbjct: 9 NQQARIKDKIDAGIQRVLRH-------GQYILGPEVTELED----RLADFVGAKY---CI 54 Query: 139 FTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNED 198 N T+A+ +V + G + PGDEVI + + ++ GA +V ++ Sbjct: 55 SCANGTDALQIVQMALG---VGPGDEVITPGFTYVATAETVALL----GAKPVYVDIDPR 107 Query: 199 E-VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP 255 D L I+P+TK A+ VS + + I A G V+ DA QS Sbjct: 108 TYNLDPQLLEAAITPRTK--AIIPVS-LYGQCADFDAINAIASKYGIPVIEDAAQSFG 162 >4OBV-D nrPDB Length = 490 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 53/298 (17%), Positives = 94/298 (31%), Gaps = 19/298 (6%) Query: 102 NVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKP 161 N+H G L+ + K +A+ + +++ VF + A N+ A + N Sbjct: 118 NIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTENPGGVFVSGGSMA-NITALTAARDNKLT 176 Query: 162 GDEVILTVA----EHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK-- 215 + L A + HS + + T + ++ + N D KL E I K Sbjct: 177 DINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIPTNSHFQMDTTKLEEAIETDKKSG 236 Query: 216 ---LVAVHHVSNV-LASSLPIEEIVVWAHDVGAKVLVDACQSV-----PHMVVDVQKLN- 265 V + S P+ EI +D P + Sbjct: 237 YIPFVVIGTAGTTNTGSIDPLTEISALCKKHDMWFHIDGAYGASVLLSPKYKSLLTGTGL 296 Query: 266 ADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAG 325 AD + +HK T + D+ + F E + D+ D E Sbjct: 297 ADSISWDAHKWLFQTYGCAMVLVKDIRNLFHSFHVNPEYLKDLENDIDNVNTWDIGMELT 356 Query: 326 TPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVH 383 PA G + L + L + E+ ++ + E L+ D I P ++ Sbjct: 357 RPARG--LKLWLTLQVLGSDLIGSAIEHGFQLAVWAEEALNPKKDWEIVSPAQMAMIN 412 >2HUU-A nrPDB Length = 393 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 29/200 (14%), Positives = 71/200 (35%), Gaps = 18/200 (9%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNAT 144 P VLDA+ + +H + + ++ V ++ + + Sbjct: 31 PQRVLDAMSR-------PILGHLHP---ETLKIMDDIKEGVRYLFQTNNIATFCLSASGH 80 Query: 145 EAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDIN 204 + + L+ GD +++ H ++ + GA ++ V + ++ Sbjct: 81 GG----MEATLCNLLEDGDVILIGHTGHWGDRSA--DMATRYGADVRVVKSKVGQSLSLD 134 Query: 205 KLR-ELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQK 263 ++R L+ K ++ + + +E + H ++VD S+ + + + Sbjct: 135 EIRDALLIHKPSVLFLTQGDSSTGVLQGLEGVGALCHQHNCLLIVDTVASLGGAPMFMDR 194 Query: 264 LNADFLVASSHKMCG-PTGI 282 D + S K+ G P GI Sbjct: 195 WEIDAMYTGSQKVLGAPPGI 214 >3AEO-A nrPDB Length = 389 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 36/169 (21%), Positives = 64/169 (37%), Gaps = 13/169 (7%) Query: 108 HYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVIL 167 H S E + V A+ S F S L+ L+ GD +I Sbjct: 51 HIYSRLGNPTVEQFEEMVCSIEGAAGSA--AFGSGMG-----AISSSTLAFLQKGDHLIA 103 Query: 168 TVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLA 227 + + + + G + + + D+ K++ P TK+V + +N Sbjct: 104 GDTLYGCTVSLFTHWLPRFGIEVDLIDTS-----DVEKVKAAWKPNTKMVYLESPANPTC 158 Query: 228 SSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM 276 I+ I V H+ GA+++VDA + P + ++ L AD + S K Sbjct: 159 KVSDIKGIAVVCHERGARLVVDATFTSPCFLKPLE-LGADIALHSVSKY 206 >4M2J-A nrPDB Length = 406 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 86/244 (35%), Gaps = 29/244 (11%) Query: 119 ELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVP 178 E R+ +A D+ ++ T ++EAI L + L GD V++ +HS Sbjct: 87 EGVRRAIADRYAGGDADRVLVTHGSSEAIALTLNAL----LHRGDRVVVQEGIYHS---- 138 Query: 179 WQIVSQKTGAVLKFVTLNE--DEVPDINKLRELISPKTKLVAVHHVSNVLASS---LPIE 233 + G + + D D + L L++P T V V+ N + + Sbjct: 139 LGHYPRAAGCDVAVLPGRAVRDGEIDPDVLAGLVTPGTAAVIVNFPHNPTGVTLSPQGLR 198 Query: 234 EIVVWAHDVGAKVLVDACQS-VPHMVVDVQKLNADFLVASSH----KMCGPTG--IGFLY 286 + GA ++ DA + + H + AD S+ K G G +G+ Sbjct: 199 ALKERTAATGAVLVWDAATAEIAHRWEVLADPGADGGDTVSYGTLSKTFGLPGLRVGWAV 258 Query: 287 GKSDLLHSMPPFLGGG--------EMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAA 338 +LL + P E++++ + H+ EA + AA Sbjct: 259 APKELLTATFPLRDRTTLFLSPLVELVAERAVRHADELIGARAAEA-RHNLAHLTGWMAA 317 Query: 339 VDYL 342 + L Sbjct: 318 HEEL 321 >3RI6-A nrPDB Length = 430 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 63/169 (37%), Gaps = 13/169 (7%) Query: 108 HYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVIL 167 H S + E +++ A ++ + AI+ + + GD V+ Sbjct: 74 HVYSRSSNPTVEDLEQRLKNLTGAL---GVLALGSGMAAISTAILTLARA----GDSVVT 126 Query: 168 TVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLA 227 T + +Q G ++FV + D + TKL+ + +SN Sbjct: 127 TDRLFGHTLSLFQKTLPSFGIEVRFVDV-----MDSLAVEHACDETTKLLFLETISNPQL 181 Query: 228 SSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM 276 +E + H G ++VD + P++ ++ ++L D V SS K Sbjct: 182 QVADLEALSKVVHAKGIPLVVDTTMTPPYL-LEAKRLGVDIEVLSSTKF 229 >1O4S-A nrPDB Length = 389 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 74/403 (18%), Positives = 140/403 (34%), Gaps = 92/403 (22%) Query: 83 QKPAAVLDALQNYYEFY---NSNVHRGIHYLSAKATDEFELARKKVARFINAS-----DS 134 P V++ + + ++ RGI+ R+ +A+ I Sbjct: 54 PTPEPVVEEAVRFLQKGEVKYTDP-RGIY-----------ELREGIAKRIGERYKKDISP 101 Query: 135 REIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVT 194 ++V T A +A+ ++ ++ L PGDEVI+ S +P I++ T V++ Sbjct: 102 DQVVVTNGAKQAL----FNAFMALLDPGDEVIVFSPVWVS-YIPQIILAGGTVNVVETF- 155 Query: 195 LNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP---IEEIVVWAHDVGAKVLVDAC 251 ++++ P + ++ L+ KTK V ++ +N +E +V A ++ D Sbjct: 156 MSKNFQPSLEEVEGLLVGKTKAVLINSPNNPTGVVYRREFLEGLVRLAKKRNFYIISDEV 215 Query: 252 -QSVPHMV-----VDVQKLNADFLVA-----SSHKMCGPTGIGFLYGKSDLLHSMPPFLG 300 S+ + +DV + D +V SH M G +G+L + Sbjct: 216 YDSLVYTDEFTSILDVSE-GFDRIVYINGFSKSHSMTGWR-VGYLISSEKV--------- 264 Query: 301 GGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKY 360 A S+ ++ T + +A AA+ L + + E + Sbjct: 265 ---------------ATAVSKIQSHTTSCINTVAQYAALKALEVDNSYMVQTF-KERKNF 308 Query: 361 LYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLA--TFLDQQHGVAIRSGHHC 418 + E+L V+ P F V G D+ L ++ VA+ G Sbjct: 309 VVERLKK-MGVKFVEP------EGAFYLFFKVRG---DDVKFCERLLEEKKVALVPGSAF 358 Query: 419 AQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 +P R S ++ AL F NS Sbjct: 359 LKP--------GFVRLSFA-----TSIERLTEALDRIEDFLNS 388 >4OTL-A nrPDB Length = 423 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 84/235 (35%), Gaps = 26/235 (11%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSA-KATDEFEL-ARKKVARFINASDSREIVFTRNA 143 AV+ A + + + G Y + D E A +V + A + V + Sbjct: 50 PAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAAN--VQPNSG 107 Query: 144 TEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIV---PWQIVSQKTGAVLKFVTLNEDEV 200 ++A + LKPGD ++ H + P + + + LNE+E Sbjct: 108 SQAN----QGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKW--FNVVSYGLNENED 161 Query: 201 PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQ-----SVP 255 D + +L + + V S A + E + A VGA ++VD + Sbjct: 162 IDYDAAEKLANEHKPKLIVAGAS-AFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAG 220 Query: 256 HMVVDVQKLNADFLVASSHK-MCGPTGIGFL----YGKSDLLHSMPPFLGGGEMI 305 V +ADF+ ++HK + GP G L Y K P GG M Sbjct: 221 VYPNPVP--HADFVTTTTHKSLRGPRGGVILMKAEYEKPINSAIFPGIQGGPLMH 273 >3MKJ-A nrPDB Length = 398 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 37/155 (23%), Positives = 63/155 (40%), Gaps = 9/155 (5%) Query: 143 ATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPD 202 AT + + L+ + GD ++ A + K G + FV + Sbjct: 84 ATASGISAITTTLLTLCQQGDHIVSASAIYGCTHAFLSHSMPKFGINVSFVDAAKP---- 139 Query: 203 INKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQ 262 ++R + P+TK+V + +N S + IE + AH GA ++VD P+ +Q Sbjct: 140 -EEIRAAMRPETKVVYIETPANPTLSLVDIETVAGIAHQQGALLVVDNTFMSPYCQQPLQ 198 Query: 263 KLNADFLVASSHKM---CGPTGIGFLYGKSDLLHS 294 L AD +V S K G G + GK + + Sbjct: 199 -LGADIVVHSVTKYINGHGDVIGGIIVGKQEFIDQ 232 >3FFH-A nrPDB Length = 363 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 35/174 (20%), Positives = 65/174 (37%), Gaps = 26/174 (14%) Query: 77 DSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSRE 136 ++ + K A + A NS+V I+ ++ RK+VA F + E Sbjct: 41 ENPLGTSKKVAAIQA--------NSSVETEIYPDGWASS-----LRKEVADFYQLEE-EE 86 Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQK--TGAVLKFVT 194 ++FT E I L+ T + Q GA ++ + Sbjct: 87 LIFTAGVDELIELLTRVLLD----------TTTNTVMATPTFVQYRQNALIEGAEVREIP 136 Query: 195 LNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLV 248 L +D D+ + I KT +V + + +N + + + +I + V + VLV Sbjct: 137 LLQDGEHDLEGMLNAIDEKTTIVWICNPNNPTGNYIELADIQAFLDRVPSDVLV 190 >4U1T-A nrPDB Length = 389 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 58/328 (17%), Positives = 111/328 (33%), Gaps = 63/328 (19%) Query: 92 LQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVA 151 + YE + R ++ E + +A VF+ A L+ Sbjct: 30 VSTTYERRAQDEPR--YFYGRGENPTREELEECLAGL--ERAPFATVFSSGQAAAATLL- 84 Query: 152 YSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELIS 211 S ++PG + +++ + ++ ++ + G +++ L E L Sbjct: 85 -----SLVRPG-QCVVSTDDVYAGTDGLFDLAARQGVRVRYADLTTPEGIAA----ALAE 134 Query: 212 PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVA 271 P LV + +N L + + + E+ AH+ GA+V+VD + P + + L AD + Sbjct: 135 PDLALVWIETPTNPLLTVVDVAEVSRRAHERGARVVVDNTFASPVLQQPL-ALGADVSLY 193 Query: 272 SSHK-MCG---PTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTP 327 S+ K + G G +Y +DL + V +T P + Sbjct: 194 STTKSIAGHADVLGGALVYRDADL-------------HAAVRAYRTTAGNVPGALDC--- 237 Query: 328 AIGEAIALGAAVDYLSGIGMPKIHEYEVE---IGKYLYEKLSSLPDVR-IYGPRPSESVH 383 +L G+ + + L E+L + P V ++ P E Sbjct: 238 -------------FLVRRGLHTLSLRVHRQVATARVLVERLRASPVVGAVHYPGLPEHPQ 284 Query: 384 R----------GALCSFNVEGLHPTDLA 401 GA+ SF+ G L Sbjct: 285 HAVVKAQMSAPGAIVSFDYLGGPAERLL 312 >3QI6-A nrPDB Length = 392 Score = 54.8 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 12/165 (7%) Query: 150 VAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQK-TGAVLKFVTLNEDEVPDINKLRE 208 A + L+PGD V++ + ++++ + TG +++ + + D++ +R Sbjct: 93 AADCALRAMLRPGDHVVIP---DDAYGGTFRLIDKVFTGWNVEYTPVA---LADLDAVRA 146 Query: 209 LISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADF 268 I P T+L+ V +N L S I I D AKVLVD + P + + L AD Sbjct: 147 AIRPTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVDNTFASPALQQPLS-LGADV 205 Query: 269 LVASSHKMCG----PTGIGFLYGKSDLLHSMPPFLGGGEMISDVF 309 ++ S+ K G G + +L S G + F Sbjct: 206 VLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGAVPGPF 250 >4KAM-A nrPDB Length = 453 Score = 54.8 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 94/292 (32%), Gaps = 29/292 (9%) Query: 110 LSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTV 169 L TD E +++A + +F + A + + GD ++ + Sbjct: 74 LGNPTTDVVE---QRIAALEGGVAA---LFLSSGQAAETFAILNLAGA----GDHIVSSP 123 Query: 170 AEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASS 229 + + K G + FV D+ +++ + + P TK +SN Sbjct: 124 RLYGGTYNLFHYSLAKLGIEVSFV----DDPDNLDSWQAAVRPNTKAFFGETISNPQIDL 179 Query: 230 LPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTG--IGFLYG 287 L + AH G ++VD + P+++ + AD +V S+ K G G I + Sbjct: 180 LDTPGVAEVAHRNGIPLIVDNTIATPYLIRPFTQ-GADIVVHSATKYLGGHGAAIAGVIV 238 Query: 288 KSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGM 347 GG + T +P A AL A V L +G Sbjct: 239 D-----------GGTFDWTQGRFPEFTTPDPSYHGVVFAELGAPAYALKARVQLLRDLGS 287 Query: 348 PKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSE-SVHRGALCSFNVEGLHPT 398 + + L + R +E R + + N GL + Sbjct: 288 AASPFNAFLVAQGLETLSLRIERHVSNAQRVAEFLADREDVVTVNYAGLPGS 339 >1J32-A nrPDB Length = 388 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 70/394 (17%), Positives = 127/394 (32%), Gaps = 73/394 (18%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDS-----REIVF 139 P +++A + E G A + R+ +A+ + + I+ Sbjct: 45 PKHIVEAAKAALEQ-------GKTRYGPAAGE--PRLREAIAQKLQRDNGLCYGADNILV 95 Query: 140 TRNATEAI-NLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF-VTLNE 197 T ++I NL+ + ++PGDEVI+ S ++V G + T+ Sbjct: 96 TNGGKQSIFNLML-----AMIEPGDEVIIPAPFWVSYP---EMVKLAEGTPVILPTTVET 147 Query: 198 DEVPDINKLRELISPKTKLVAVHHVSNVLASS---LPIEEIVVWAHDVGAKVLVDACQSV 254 ++R+ I+PKTKL+ + SN + I A + G VL D Sbjct: 148 QFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVLSDEIYE- 206 Query: 255 PHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHST 314 ++ D +A L + + G + + Sbjct: 207 -KILYD----DAQHLSIGA-------------ASPEAYERSVVCSGFAKTYAMTGWRVGF 248 Query: 315 YAEPPSRFEAGTPAIGEAI---------ALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKL 365 A P +A T G + AA + S + ++ E +Y+ + L Sbjct: 249 LAGPVPLVKAATKIQGHSTSNVCTFAQYGAIAAYEN-SQDCVQEMLAAFAERRRYMLDAL 307 Query: 366 SSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLHRY 425 +++P + P+P + + S G D + L QH VA G Sbjct: 308 NAMPGLEC--PKPDGAFYMFP--SIAKTGRSSLDFCSELLDQHQVATVPGAA-------- 355 Query: 426 LGVNASARASLYFYNTKDDVDAFIVALADTVSFF 459 G + R S D+D + F Sbjct: 356 FGADDCIRLSYA-----TDLDTIKRGMERLEKFL 384 >1IBJ-A nrPDB Length = 464 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 44/195 (22%), Positives = 74/195 (37%), Gaps = 17/195 (8%) Query: 101 SNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLK 160 S + G + + + +A+ A R FT + A S +K Sbjct: 118 SAIENGPYDYTRSGNPTRDALESLLAKLDKA--DRAFCFTSG------MAALSAVTHLIK 169 Query: 161 PGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVH 220 G+E++ + V ++G V+K V ++++ I P+TKLV + Sbjct: 170 NGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-----NTTKLDEVAAAIGPQTKLVWLE 224 Query: 221 HVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM---C 277 +N I +I AH GA VLVD P + ++ L AD ++ S+ K Sbjct: 225 SPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLE-LGADIVMHSATKFIAGH 283 Query: 278 GPTGIGFLYGKSDLL 292 G L K + L Sbjct: 284 SDVMAGVLAVKGEKL 298 >2CB1-A nrPDB Length = 412 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 90/245 (36%), Gaps = 19/245 (7%) Query: 160 KPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAV 219 +PGDEV+ I + V G +++V P+ +RE +S KT+ V V Sbjct: 93 RPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVD------PEPEAVREALSAKTRAVFV 146 Query: 220 HHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKM--- 276 V+N +E + A + G ++VD + A +V S K Sbjct: 147 ETVANPALLVPDLEALATLAEEAGVALVVDNTFGAAGALCRPLAWGAHVVVESLTKWASG 206 Query: 277 CGPTGIGFLYGKS-DLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEA-GTPAIGEAIA 334 G G + + +L + P FL ++ + + P R G G A++ Sbjct: 207 HGSVLGGAVLSRETELWRNYPQFLQP-DLKGQIPWEALRARCFPERVRTLGLSLCGMALS 265 Query: 335 LGAAVDYLSGIGMPKIHEYEVEIGK---YLYEKLSSLPDVRI--YGPRPSESVHRGALCS 389 A YL G+ + + + +L E+L P V+ Y P + HR A Sbjct: 266 PFNA--YLLFQGLETVALRVARMSETARFLAERLQGHPKVKALRYPGLPEDPAHRNARKY 323 Query: 390 FNVEG 394 G Sbjct: 324 LASGG 328 >5K8B-A nrPDB Length = 403 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 100/314 (31%), Gaps = 42/314 (13%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 V D +++ + F + H K D +L +K +N + + T Sbjct: 13 QEVADVMEHGFTFRYNFDHMRND--RWKTRDMEQLLCEK----MNVKHAH---LLSSGTA 63 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINK 205 A+ + G + GDEVI+ + + + GAV F ++E Sbjct: 64 ALQTAMMAAG---IGAGDEVIVPPFTFVASVEAIFMA----GAVPIFAEIDETLCLSPEG 116 Query: 206 LRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSV-----PHMVVD 260 + +I+P+TK + + H+ S ++EI +L DACQ++ + Sbjct: 117 IEAVITPRTKAINLVHM---CGSMAKMDEIKAICKKHNLVLLEDACQAIGGSYKGQALGT 173 Query: 261 VQKLNADFLVASSHK--MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEP 318 + + S K CG G + +++ + F G + D + P Sbjct: 174 IGDVGC--YSFDSVKTITCG-EGGAVITNNTEIYDNAHMFSDHG--HDHIGKDRGAESHP 228 Query: 319 PSRFEAGTPAIGEAIALGA--AVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGP 376 + A+ L +D + I + + +PD Sbjct: 229 IMGLNFRISEMNAALGLAQLRKLDTIIDIQRKNKKAIKDAMASIPEVSFREIPD------ 282 Query: 377 RPSESVHRGALCSF 390 SF Sbjct: 283 ---PEGDSAGFLSF 293 >3WY7-A nrPDB Length = 404 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 66/212 (31%), Gaps = 18/212 (8%) Query: 47 DSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRG 106 D E +R++ R+ L D SQ P VLD + Sbjct: 36 DIEQRRRAEGLRRELRVRPPVAAELDLASNDYLGLSQHPD-VLDGGVEALRTWGGGAGGS 94 Query: 107 IHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVI 166 T+ E ++A F+ A + +VF+ T + ++ PG ++ Sbjct: 95 RLVTGN--TELHEAFEHQLASFLGAESA--LVFSSGYTANL-----GALVALSGPGSLIV 145 Query: 167 LTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVH-HVSNV 225 H S + ++ + V ++ D + + V V V + Sbjct: 146 SDALSHASLVDACRLSRAR-------VVVSPHRDVDAVDAALAARTEERAVVVTESVFSA 198 Query: 226 LASSLPIEEIVVWAHDVGAKVLVDACQSVPHM 257 P+ ++ GA +LVD + Sbjct: 199 DGDLAPLRDLHAVCRRHGALLLVDEAHGLGVR 230 >5O5C-A nrPDB Length = 519 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 45/329 (13%), Positives = 93/329 (28%), Gaps = 61/329 (18%) Query: 101 SNVHRGIHYLSAKA--TDEFELARKKVARFINASDSREIVFTRNATEAINLV-------- 150 + V+ + A T + I + +FT T++ + Sbjct: 126 AAVNSSVDTWDQSAGGTLIEQKVIDWTLSRIGLPAGADGIFTSGGTQSNLMAMLLARDSW 185 Query: 151 ---------AYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVP 201 GL + V + H S I+ A + ++ DE Sbjct: 186 CAAHHPGHLIKHRGLPHDAAKWRVFTSKLSHFSIQKSMAILGLGYDA---VIPVDYDERY 242 Query: 202 DIN------KLRELISPKTKLVAVHHVSNVL--ASSLPIEEIVVWAHDVGAKVLVDACQS 253 ++ +++ + VAV S S P+ I G + VDA Sbjct: 243 RMDVDCLKQEVQRCLQQGLIPVAVVATSGTTDFGSIDPLGAISELCKHHGMWMHVDAAYG 302 Query: 254 VP------HMVVDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLLHSMPPFLGGGEMIS 306 H AD + HK G + + + Sbjct: 303 CGLLVSESHRPRLAGIEKADSVTVDYHKSFFQTVSCGAFFVRD-------------KHHL 349 Query: 307 DVFLDHSTYAEPPSRFEAGTPAIGE----------AIALGAAVDYLSGIGMPKIHEYEVE 356 H+ Y P S + GTP + A+ + + + + + + Sbjct: 350 SHVTHHADYLNPLSAQQEGTPNLVNKSIQTTRRFDALKMWLTLRVSGPMALGNAFDDILA 409 Query: 357 IGKYLYEKLSSLPDVR-IYGPRPSESVHR 384 + + ++ L++ P + ++ P + + R Sbjct: 410 LTQIAHQLLNAHPAIEVLHVPELTTQIFR 438 >3UWC-A nrPDB Length = 374 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 39/179 (21%), Positives = 68/179 (37%), Gaps = 13/179 (7%) Query: 82 SQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTR 141 + P + L+ E Y +++ I E E K+ A NA + + Sbjct: 4 MRVPYSYLERQFADIEPYLNDLREFIKTADFTLGAELEKFEKRFAALHNAPHAIGV---G 60 Query: 142 NATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVP 201 T+A+ + S+ + N+ GDEVI ++ I + Q GA V V Sbjct: 61 TGTDALAM---SFKMLNIGAGDEVITCA---NTFIASVGAIVQ-AGATPVLVDSENGYVI 113 Query: 202 DINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVD 260 D K+ I+ KTK + H + + + A ++ DACQ++ + D Sbjct: 114 DPEKIEAAITDKTKAIMPVHY---TGNIADMPALAKIAKKHNLHIVEDACQTILGRIND 169 >2CTZ-A nrPDB Length = 421 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 41/240 (17%), Positives = 80/240 (33%), Gaps = 21/240 (8%) Query: 110 LSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTV 169 S ++ K++A AT + + + + + GD ++ T Sbjct: 52 YSRIMNPTVDVLEKRLAALEGGKA-------ALATASGHAAQFLALTTLAQAGDNIVSTP 104 Query: 170 AEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASS 229 + +++ ++ G ++F + E + L KT+ V + N + Sbjct: 105 NLYGGTFNQFKVTLKRLGIEVRFTSREERP----EEFLALTDEKTRAWWVESIGNPALNI 160 Query: 230 LPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKS 289 +E + A + G ++VD + ++ A + S K G G G + + Sbjct: 161 PDLEALAQAAREKGVALIVDNTFGMGGYLLRPLAWGAALVTHSLTKWVG--GHGAVIAGA 218 Query: 290 DLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAA-VDYLSGIGMP 348 + P+ GG T +P T A GE + A VD L G Sbjct: 219 IVDGGNFPWEGG-------RYPLLTEPQPGYHGLRLTEAFGELAFIVKARVDGLRDQGQA 271 >1GC4-A nrPDB Length = 385 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 40/171 (23%), Positives = 71/171 (41%), Gaps = 19/171 (11%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN-ASDSREIVFTRNA 143 P V +A + + + A + E +K R + E + T Sbjct: 46 PEHVKEAARRALAQG-----KTKYAPPAGIPELREALAEKFRRENGLSVTPEETIVTVGG 100 Query: 144 TEAI-NLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE-VP 201 ++A+ NL + L PGDEVI+ S ++V G V++ TL E+ VP Sbjct: 101 SQALFNLF-----QAILDPGDEVIVLSPYWVSYP---EMVRFAGGVVVEVETLPEEGFVP 152 Query: 202 DINKLRELISPKTKLVAVHHVSNVLASSLP---IEEIVVWAHDVGAKVLVD 249 D ++R I+P+TK + V+ +N + P +E + A + ++ D Sbjct: 153 DPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSD 203 >4IYO-A nrPDB Length = 397 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 53/279 (18%), Positives = 87/279 (31%), Gaps = 27/279 (9%) Query: 81 TSQKPAAVLDALQN--YYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIV 138 Q P A+ Y + G H + + R R + A + Sbjct: 24 GGQSPDPSTGAVMPPIYATSTYAQSSPGEHQ-GFEYSRTHNPTRFAYERCVAALEGG--- 79 Query: 139 FTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNED 198 TR A + A S + L G V+ + ++ + + Sbjct: 80 -TRAFAFASGMAATSTVMELLDAGSHVVAM----DDLYGGTFRLFERVRRRTAGLDFSFV 134 Query: 199 EVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP--H 256 ++ D + I TK+V + +N + + I I V A G +VD + P Sbjct: 135 DLTDPAAFKAAIRADTKMVWIETPTNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQ 194 Query: 257 MVVDVQKLNADFLVASSHKMCG-----PTGIGFLYGKSDLLHSMPPFL---GGGEMISDV 308 + L AD +V S+ K GI + ++L M GG + D Sbjct: 195 RPLS---LGADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDS 251 Query: 309 FLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGM 347 FL P R A A+AL ++ I Sbjct: 252 FLALRGLKTLPLRMRAHCEN---ALALAQWLETHPAIEK 287 >4J8L-A nrPDB Length = 361 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 78/210 (37%), Gaps = 14/210 (6%) Query: 150 VAYSWGLSNLKPGDEVILTVAEHHS-CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRE 208 + + LKPG +++ H + +++ ++ G L +T++ +++ + ++ + Sbjct: 78 AIRAGLAALLKPGQRLLV----HDAPVYPTTRVIIEQMG--LTLITVDFNDLSALKQVVD 131 Query: 209 LISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADF 268 P LV + + +++ G L D +V + + A+ Sbjct: 132 EQQPDAALVQHTRQQPQDSYV--LADVLATLRAAGVPALTDDNYAVMKVARIGCECGANV 189 Query: 269 LVASSHKMCGPTGIGFLYGKSDLLHSMP-PFLGGGEMISDV----FLDHSTYAEPPSRFE 323 S K+ GP G+G + G +D+++ + GG I L +A + Sbjct: 190 STFSCFKLFGPEGVGAVVGDADVINRIRATLYSGGSQIQGAQALEVLRGLVFAPVMHAVQ 249 Query: 324 AGTPAIGEAIALGAAVDYLSGIGMPKIHEY 353 AG A+ G AV + + Sbjct: 250 AGVSERLLALLNGGAVPEVKSAVIANAQSK 279 >3DR4-A nrPDB Length = 391 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 103/339 (30%), Gaps = 49/339 (14%) Query: 141 RNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEV 200 N T A++L + G + PGDEVI+ + + T ++ + Sbjct: 78 NNGTTALHLALVAMG---IGPGDEVIVPSLTYIASANSVTY-CGATPVLVDNDPRTFN-- 131 Query: 201 PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM--- 257 D KL LI+P+TK + H+ ++ I+ A V+ DA ++V Sbjct: 132 LDAAKLEALITPRTKAIMPVHL---YGQICDMDPILEVARRHNLLVIEDAAEAVGATYRG 188 Query: 258 VVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAE 317 + + + G + D L + L G M + Y Sbjct: 189 KKSGSLGDCATFSFFGNAIITTGEGGMITTNDDDLAAKMRLLRGQGMDPNR-----RYWF 243 Query: 318 PPSRFEAGTPAIGEAIALGA--AVDYLSGIGMPKIHEYEVEIGKYL------YEKLSSLP 369 P F I AI L VD + YE ++ + + L+ Sbjct: 244 PIVGFNYRMTNIQAAIGLAQLERVDEHLAARERVVGWYEQKLARLGNRVTKPHVALTGRH 303 Query: 370 DVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIR----------SGHHCA 419 +Y R E + + LD G+ R H A Sbjct: 304 VFWMYTVRLGEGLSTT-----------RDQVIKDLDAL-GIESRPVFHPMHIMPPYAHLA 351 Query: 420 QPLHRYLGVNASARASLYFYN--TKDDVDAFIVALADTV 456 + +L + T+ D+D I AL + Sbjct: 352 TDDLKIAEACGVDGLNLPTHAGLTEADIDRVIAALDQVL 390 >2GB3-A nrPDB Length = 409 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 50/331 (15%), Positives = 112/331 (33%), Gaps = 55/331 (16%) Query: 89 LDALQNYYEFYNSN-------VHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTR 141 L + ++E N H + +A + R++V ++ T Sbjct: 55 LKTPEVFFERIYENKPEVVYYSHSAGIWELREAFASYYKRRQRVD-----VKPENVLVTN 109 Query: 142 NATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN---ED 198 +EAI +S+ + PGDE+++ ++ + ++ +K + + E+ Sbjct: 110 GGSEAI---LFSFAVI-ANPGDEILVLEP-FYANYNAFAKIAG-----VKLIPVTRRMEE 159 Query: 199 EVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI---VVWAHDVGAKVLVDACQSVP 255 L I+ +TK + + + N +E+ V A G ++VD S Sbjct: 160 GFAIPQNLESFINERTKGIVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYSEI 219 Query: 256 HMV------VDVQKLNADFLVASSHKM--CGPTGIGFLYGKSDLLHSMPPFLGGGEMISD 307 + ++ + + S K CG +G L +++ E+IS Sbjct: 220 VFRGEFASALSIESDKVVVIDSVSKKFSACGAR-VGCLITRNE------------ELISH 266 Query: 308 VFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSS 367 PP + G+ +G + D++ ++ ++ ++ ++ + Sbjct: 267 AMKLAQGRLAPPLLEQIGS--VGLLNLDDSFFDFVRETYRERVETVLKKLEEHGLKRFTK 324 Query: 368 LPDVRIYGPRPS----ESVHRGALCSFNVEG 394 E R L FN++G Sbjct: 325 PSGAFYITAELPVEDAEEFARWMLTDFNMDG 355 >4L0O-H nrPDB Length = 388 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 41/222 (18%), Positives = 73/222 (32%), Gaps = 24/222 (10%) Query: 57 VRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 +R +++H ++ A T + + Y H+G + S Sbjct: 1 MRMQTKLIHGGISED-------ATTGAVSVPIYQT--STYRQDAIGRHKG-YEYSRSGNP 50 Query: 117 EFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCI 176 + +A F L S L+ GD V+L + Sbjct: 51 TRFALEELIADLEGGVKG--FAFASG------LAGIHAVFSLLQSGDHVLLGDDVYGGTF 102 Query: 177 VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 + V K G + + DI+++++ I P TK + + SN L + + Sbjct: 103 RLFNQVLVKNGLSCTIIDTS-----DISQIKKAIKPNTKALYLETPSNPLLKITDLAQCA 157 Query: 237 VWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCG 278 A D G +VD + P+ + L AD + S K G Sbjct: 158 SVAKDHGLLTIVDNTFATPYYQNPL-LLGADIVAHSGTKYLG 198 >5X5H-A nrPDB Length = 392 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 42/222 (18%), Positives = 71/222 (31%), Gaps = 17/222 (7%) Query: 92 LQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVA 151 + N R + + + VA A R F+ L Sbjct: 34 ASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVAALEGAKYGR--AFSSGMAATDILF- 90 Query: 152 YSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELIS 211 LKPGD ++L + V G V + + +++ I Sbjct: 91 ----RIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVVDTSV-----VEEVKAAIK 141 Query: 212 PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVA 271 TKL+ V +N IE + AK++VD + P++ + KL A ++ Sbjct: 142 DNTKLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVDNTFASPYLQQPL-KLGAHAVLH 200 Query: 272 SSHKMCG----PTGIGFLYGKSDLLHSMPPFLGGGEMISDVF 309 S+ K G G + ++ + GG I VF Sbjct: 201 STTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVF 242 >2GMS-A nrPDB Length = 390 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 11/122 (9%) Query: 138 VFTRNATEAINLVAYSWGL---SNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVT 194 V + + A L+ + LK GDE+I+ + P Q + G +KFV Sbjct: 53 VMVSSGSTANLLMIAALFFTKKPRLKKGDEIIVPAVSWSTTYYPLQ----QYGLRVKFVD 108 Query: 195 LNEDEV-PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQS 253 ++ + + DI L+E ++ TK A+ V N+L + +EI +L D C+S Sbjct: 109 IDINTLNIDIESLKEAVTDSTK--AILTV-NLLGNPNNFDEINKIIGGRDIILLEDNCES 165 Query: 254 VP 255 + Sbjct: 166 MG 167 >2X8U-A nrPDB Length = 412 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 62/400 (15%), Positives = 119/400 (29%), Gaps = 61/400 (15%) Query: 68 VNGSKLVYLD--SAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSA-KATDEFELARKK 124 +NG K + L + V+ A + + + S + E A Sbjct: 41 INGRKTILLGTYNYMGMTFDPDVIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDA--- 97 Query: 125 VARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQ 184 + F + IVF+ + ++ + GD +IL H S + Sbjct: 98 LKEFYGTEHA--IVFSTGYQANLGMI-----STLAGKGDYIILDADSHASIYDGCWL--- 147 Query: 185 KTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGA 244 A + N E D +L L + KLV + V +++ P++E+V + GA Sbjct: 148 -GDAEIVRFRHNSVEDLD-KRLGRLPAEAGKLVVLEGVYSMMGDIAPLQEMVAVSKKHGA 205 Query: 245 KVLVDACQSVPHM---------VVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSM 295 +LVD + V+ + DF+V + K G Sbjct: 206 MILVDEAHGMGFFGEHGRGVFEEAGVEA-DVDFVVGTFSKSVG----------------- 247 Query: 296 PPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEV 355 +GG + + + P F A P A A + + Sbjct: 248 --TVGGFCVSNHPKFEVLRLVCRPYVFTASLPPSVVATAATSIRKLMHAGDKRA------ 299 Query: 356 EIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSG 415 +R G + + A+ + + + + G+ + + Sbjct: 300 ---HLWKNSRRLHQGLRDMGYKLGTETAQSAIIAVILTDMAQAVALWQGLLEAGLYVNTA 356 Query: 416 HHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADT 455 A P +L R SL ++ + V+ + Sbjct: 357 RPPATPAGMFL-----LRCSLCAEHSDEQVEQILGMFESA 391 >3VOM-A nrPDB Length = 398 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 87/294 (29%), Gaps = 20/294 (6%) Query: 120 LARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPW 179 R +A + D E++ A A ++GL + + S + + Sbjct: 82 RVRSGLAELFSLPDGYEVILGNGGATAF-WDAAAFGLIDKR-------------SLHLTY 127 Query: 180 QIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKT--KLVAVHHVSNVLASSLPIEEIVV 237 S K + + + + + P+T + + N ++ + + + Sbjct: 128 GEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVA-VRR 186 Query: 238 WAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPP 297 A V++DA + VD+ + +A + + G+ L + Sbjct: 187 PEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKN-FASDGGLWLAIMSPAALSRIEA 245 Query: 298 FLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGI-GMPKIHEYEVE 356 G + D TPAI L +D+L G G+ + + Sbjct: 246 IAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTAD 305 Query: 357 IGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGV 410 + LY P + P F V+ + +A L V Sbjct: 306 SSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDF-VDDVDAGTVAKILRANGIV 358 >2O0R-A nrPDB Length = 411 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 42/106 (39%), Gaps = 11/106 (10%) Query: 133 DSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 E++ T ATEAI ++PG EV+L + V GA Sbjct: 85 PETEVLVTVGATEAIAAAVLGL----VEPGSEVLLIEP----FYDSYSPVVAMAGAHRVT 136 Query: 193 VTLNEDE---VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI 235 V L D D + LR ++P+T+ + ++ N + L E+ Sbjct: 137 VPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATEL 182 >1CS1-A nrPDB Length = 386 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 46/185 (24%), Positives = 76/185 (41%), Gaps = 14/185 (7%) Query: 92 LQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVA 151 L + Y F N R H S + ++ ++ +A + + V T AI+LV Sbjct: 29 LSSTYNFTGFNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGA---VLTNTGMSAIHLV- 83 Query: 152 YSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELIS 211 LKPGD ++ + + ++++ + FV + D LR ++ Sbjct: 84 ---TTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFV-----DQGDEQALRAALA 135 Query: 212 PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVA 271 K KLV V SN L + I +I A +VGA +VD P + + L AD ++ Sbjct: 136 EKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPL-ALGADLVLH 194 Query: 272 SSHKM 276 S K Sbjct: 195 SCTKY 199 >1B9H-A nrPDB Length = 388 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 91/282 (32%), Gaps = 44/282 (15%) Query: 140 TRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE 199 N T A+ L G + PG EVI+ + +Q+ GAV V ++ Sbjct: 59 VTNGTHALELALQVMG---VGPGTEVIVPAFT----FISSSQAAQRLGAVTVPVDVDAAT 111 Query: 200 -VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMV 258 D + ++P+TK++ H++ ++ + + D G +L DA + Sbjct: 112 YNLDPEAVAAAVTPRTKVIMPVHMA---GLMADMDALAKISADTGVPLLQDAAHAHGA-- 166 Query: 259 VDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHST--YA 316 + G +G L + + GE + VF D T Y Sbjct: 167 ----------------RWQGKR-VGELDSIATFSFQNGKLMTAGEGGAVVFPDGETEKYE 209 Query: 317 EPPSRFEAGTPA-----IGEAIALGAAV-DYLSGIGMPKIHEYEVEIG------KYLYEK 364 R G P + + ++ + + ++ + +I L Sbjct: 210 TAFLRHSCGRPRDDRRYFHKIAGSNMRLNEFSASVLRAQLARLDEQIAVRDERWTLLSRL 269 Query: 365 LSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQ 406 L ++ V G + + F + GL +D+ Sbjct: 270 LGAIDGVVPQGGDVRADRNSHYMAMFRIPGLTEERRNALVDR 311 >3FFR-A nrPDB Length = 362 Score = 47.8 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 94/306 (30%), Gaps = 35/306 (11%) Query: 71 SKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN 130 + +Y + S+ V + + + S K + ++ A + + Sbjct: 3 NNKIYF-TPGPSELYPTVRQHMITALDEKIGVISHR----SKKFEEVYKTASDNLKTLLE 57 Query: 131 ASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAE----HHSCIVPWQIVSQKT 186 + E++F +ATE + +I E H + + Sbjct: 58 LPSNYEVLFLASATEI---------------WERIIQNCVEKKSFHCVNGSFSKRFYEFA 102 Query: 187 GAVLKFVTLNEDEVPDINKLRELIS--PKTKLVAVHHVSNVLASSLPIEEIVVWA-HDVG 243 G L E+ I+ +++ + H S+P+E+I + + Sbjct: 103 G-ELGREAYKEEAAFGKGFYPADITVPADAEIICLTHNETSSGVSMPVEDINTFRDKNKD 161 Query: 244 AKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCG-PTGIGFLYGKSDLLHSMPPFLGGG 302 A + VDA S+P+ D K+++ F S K G P G+G ++ L Sbjct: 162 ALIFVDAVSSLPYPKFDWTKIDSVF--FSVQKCFGLPAGLGVWILNDRVIEKSKALLAKR 219 Query: 303 EMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKI----HEYEVEIG 358 + I S + TP LG + I I E I Sbjct: 220 KSIGTYHTIPSMLEKARVNQTPETPNAMNIFLLGKVTGDMLQISADGIRKQTEEKAALIN 279 Query: 359 KYLYEK 364 Y+ Sbjct: 280 TYIESS 285 >1M6S-A nrPDB Length = 347 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 47/226 (20%), Positives = 82/226 (36%), Gaps = 44/226 (19%) Query: 138 VFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTL-N 196 +F + T + +++ + GDEVI E S I +++ + + + + Sbjct: 57 LFVPSGTMGNQVSI----MAHTQRGDEVI---LEADSHIFWYEVGAMAVLSGVMPHPVPG 109 Query: 197 EDEVPDINKLRELISPK------TKLVAVHHVSNVLAS-SLP---IEEIVVWAHDVGAKV 246 ++ D + +R+ I P+ T L+A+ + N +P I+EI A + G V Sbjct: 110 KNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEHGINV 169 Query: 247 LVDA-----CQSVPHMVVDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLLHSMPPF-- 298 +D + V AD ++ K +C P G + G D + Sbjct: 170 HIDGARIFNASIASGVPVKEYAGYADSVMFCLSKGLCAPVG-SVVVGDRDFIERARKARK 228 Query: 299 LGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSG 344 + GG M +AG A IAL VD L Sbjct: 229 MLGGGMR-----------------QAGVLAAAGIIALTKMVDRLKE 257 >6HRH-B nrPDB Length = 469 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 63/355 (17%), Positives = 119/355 (33%), Gaps = 52/355 (14%) Query: 77 DSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSRE 136 D S+ P VL A Q + + V G + + +++A Sbjct: 80 DYLGMSRHP-QVLQATQETLQRHG--VGAGGTRNISGTSKFHVELEQELAEL--HQKDSA 134 Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN 196 ++F+ + + + L+ + PG E+ H S I Q + A F Sbjct: 135 LLFSSCFVANDSTL---FTLAKILPGCEIYSDAGNHASMI---QGIRNSGAAKFVF---R 185 Query: 197 EDEVPDINKLRELISPKT-KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP 255 ++ + KL E +PK K+VA V ++ + P+EE+ +H GA VD +V Sbjct: 186 HNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVG 245 Query: 256 HM--------VVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISD 307 D D + + K G G G++ DL+ + + G Sbjct: 246 LYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVG-GYIASTRDLVDMVRSYAAG------ 298 Query: 308 VFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSS 367 T + PP ++ G ++ + +L Sbjct: 299 ---FIFTTSLPPMVLSGALESVRLLKG---------EEGQALRRAHQRNVKH--MRQLLM 344 Query: 368 LPDVRIYGPRPSESVH-RGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQP 421 + + P PS + R + N + L L +HG+ +++ ++ P Sbjct: 345 DRGLPVI-PCPSHIIPIRVGNAALN------SKLCDLLLSKHGIYVQAINYPTVP 392 >3MC6-C nrPDB Length = 497 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 110/330 (33%), Gaps = 47/330 (14%) Query: 103 VHRGIHYLSAKATDEFE-LARKKVARFINAS-DSREIVFTRNATEAINLV---AYSWGLS 157 V +H A + E V R NA D+ T TE++ L A + L Sbjct: 93 VANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLLLACLSAKMYALH 152 Query: 158 NLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE-VPDINKLRELISPKTKL 216 + + I+ H+ G L+ V L+ D+ K+++ I+ T L Sbjct: 153 HRGITEPEIIAPVTAHAGFDKAAYY---FGMKLRHVELDPTTYQVDLGKVKKFINKNTVL 209 Query: 217 VAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC-----------QSVPHMV-VDVQKL 264 + + + IE + A + VD+C ++ +D + Sbjct: 210 LVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKNLPLLDFRVP 269 Query: 265 NADFLVASSHKM-CGPTGIGFLYGKSDLLHS----MPPFLGGGEMISDVFLDHSTYAEPP 319 + +HK P G + ++ L + P GG Y P Sbjct: 270 GVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGG-----------LYGSPT 318 Query: 320 SRFEAGTPAIGEAIALGAAVDYLSGIG-MPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRP 378 AG+ + A + + G + E K+ ++PD+ I G Sbjct: 319 ---LAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLDIMGN-- 373 Query: 379 SESVHRGALCSFNVEGLHPTDLATFLDQQH 408 R ++ SF+ + L+ +L+ L ++ Sbjct: 374 ----PRYSVISFSSKTLNIHELSDRLSKKG 399 >4CVQ-A nrPDB Length = 431 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 96/301 (31%), Gaps = 39/301 (12%) Query: 121 ARKKVARFINASDSRE-----IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSC 175 ARK + + A R+ I +E I + L GDE+++ ++ Sbjct: 103 ARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQAL----LNSGDEMLVPAPDY--- 155 Query: 176 IVPWQIVSQKTGAVLKFV-TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP--- 231 + VS +G + ++ + D PD++ +R I+P+T+ + + + +N + Sbjct: 156 PLWTAAVSLSSGKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKEL 215 Query: 232 IEEIVVWAHDVGAKVLVDACQSVPHMVVD------VQKLNADFLVASSHKMCGPTGIGFL 285 + EIV A + D ++ D + L D L + + G+ Sbjct: 216 LMEIVEIARQHNLIIFADEI--YDKILYDDAEHHSIAPLAPDLLTITFN------GLSKT 267 Query: 286 YGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGI 345 Y + G R A PA +S Sbjct: 268 YRVAGFRQGWMVL--NGPKKHAKGYIEGLEMLASMRLCANVPAQHAIQTALGGYQSISEF 325 Query: 346 GMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPR-PSESVHRGALCSFNVEGLHPTDLATFL 404 P YE +E ++ +P V PR + FN+ D L Sbjct: 326 ITPGGRLYEQ--RNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIH----DDQKMVL 379 Query: 405 D 405 D Sbjct: 380 D 380 >2OGE-A nrPDB Length = 399 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 52/289 (17%), Positives = 90/289 (31%), Gaps = 34/289 (11%) Query: 140 TRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE 199 + +A+ L G + PGDEVI+ + I W VS + + Sbjct: 84 VNSGMDALQLALRGLG---IGPGDEVIVPSHTY---IASWLAVSATGATPVPVEPHEDHP 137 Query: 200 VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVV 259 D + + I+P+T+ + H+ ++ + A G ++ DA Q+ Sbjct: 138 TLDPLLVEKAITPRTRALLPVHL---YGHPADMDALRELADRHGLHIVEDAAQAHGARYR 194 Query: 260 DVQ-KLNADFLVASSH--KMCG--PTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHST 314 + + S + K G G + G +L + G S H T Sbjct: 195 GRRIGAGSSVAAFSFYPGKNLGCFGDGGAVVTGDPELAERLRMLRNYG---SRQKYSHET 251 Query: 315 YAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIY 374 E + AAV I + + + E LS L + Sbjct: 252 KGTNSRLDE-----------MQAAV---LRIRLAHLDSWNGRRSALAAEYLSGLAGLPGI 297 Query: 375 GPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHCAQPLH 423 G + F V +L + LD + I + H P+H Sbjct: 298 GLPVTAPDTDPVWHLFTVRTERRDELRSHLDARG---IDTLTHYPVPVH 343 >5HSI-A nrPDB Length = 634 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 58/327 (17%), Positives = 104/327 (31%), Gaps = 61/327 (18%) Query: 69 NGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIH---------YLSAKATDEFE 119 NG+ + Y S ATSQ V + H + + Sbjct: 118 NGNNVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPF 177 Query: 120 LARKKVARFINASDSREIV---------FTRNATEAINLVAYSWGLS--NLKPGDEVILT 168 ++ + E++ NA I+ V S NL+ + ++ Sbjct: 178 AMKEVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVP 237 Query: 169 VAEHHSCIVPWQIVSQKTGA---VLKFVTLNEDEVPDINKLRELIS----PKTKLVAVHH 221 +H+S W + G + V ++ + DI L +I KT ++ V Sbjct: 238 QTKHYS----WMKAADIIGIGLDQVVPVPIDSNYRMDIQALESIIRKYAAEKTPILGVVG 293 Query: 222 V--SNVLASSLPIEEIVVWAHDVGA-----KVLVDACQSVPHMVV------------DVQ 262 V S + I++IV + + VDA + ++Q Sbjct: 294 VAGSTEEGAVDGIDKIVALRQKLQKEGIYFYLHVDAAYGGYARALFLDEDDQFIPYKNLQ 353 Query: 263 KLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMP---------PFLGGGEMISDVFLDHS 313 K++A+ V + K + Y D S+ P+ GG +I D+ + + Sbjct: 354 KVHAENHVFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRDT 413 Query: 314 TYAEPPSRFEAG--TPAIGEAIALGAA 338 FE G PA+ A L + Sbjct: 414 ISYFATYVFEKGADIPALLGAYILEGS 440 >5TSU-A nrPDB Length = 422 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 41/187 (21%), Positives = 67/187 (35%), Gaps = 16/187 (8%) Query: 91 ALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLV 150 +L ++ H G S K VA A + F L Sbjct: 59 SLSTTFKQGAPGQHSG-FNYSRSGNPTRNCLEKAVAALDGAK--YCLAFASG------LA 109 Query: 151 AYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELI 210 A LK GD++I + + ++ V+ + G + FV ++ I L I Sbjct: 110 ATVTITHLLKAGDQIICMDDVYGGTNLYFRQVASEFGLKISFVDCSK-----IKLLEAAI 164 Query: 211 SPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVG-AKVLVDACQSVPHMVVDVQKLNADFL 269 +P+TKLV + +N + IE H G ++VD P+ + L AD Sbjct: 165 TPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPL-ALGADIS 223 Query: 270 VASSHKM 276 + S+ K Sbjct: 224 MYSATKY 230 >1O69-A nrPDB Length = 394 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 38/222 (17%), Positives = 80/222 (36%), Gaps = 26/222 (11%) Query: 141 RNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEV 200 +AT A++L G +K D V+ + + + P + A F+ +E Sbjct: 54 NSATAALHLALRVAG---VKQDDIVLASSFTFIASVAPICYLK----AKPVFIDCDETYN 106 Query: 201 PDINKLRELISP---KTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM 257 D++ L+ I K K + + H+ ++ ++EIV + ++ DA +++ Sbjct: 107 IDVDLLKLAIKECEKKPKALILTHL---YGNAAKMDEIVEICKENDIVLIEDAAEALGSF 163 Query: 258 VVD-----VQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDH 312 + + + +K+ +G G L GK+ + + L Sbjct: 164 YKNKALGTFGEFGV--YSYNGNKIITTSGGGMLIGKNK--EKIEKARFYSTQARENCLH- 218 Query: 313 STYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYE 354 Y + + AI + A ++ L + K YE Sbjct: 219 --YEHLDYGYNYRLSNVLGAIGV-AQMEVLEQRVLKKREIYE 257 >5F8V-A nrPDB Length = 379 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 72/405 (17%), Positives = 134/405 (33%), Gaps = 55/405 (13%) Query: 74 VYLDSAATSQKPAAVLDALQNYYEFYNSN-------VHRGIHYLSAKATDEFELARKKVA 126 Y SA + P L+ + ++ HRG H++ + + A +++ Sbjct: 6 AYNFSAGPAAVPLECLERAAAEMTNWRNSGMSVIEVSHRGKHWMEEQ-----KEATERLR 60 Query: 127 RFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEV--ILTVAEHHSCIVPWQIVSQ 184 + ++ I+F +L + + + V + T + ++ Sbjct: 61 TLLQVPENFNILFVAGGA---SLQFSAIPFNFIGEHKAVDYLCTGTWSKKAFDECKRLA- 116 Query: 185 KTGAVLKFV----TLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAH 240 G + V N EVP + + +S ++ N IE Sbjct: 117 FPGVTVNSVAGNPPANPVEVPARDTWK--LSEDAAY--FYYCDNET--IQGIE--FQQFP 168 Query: 241 DVGAKVLVDACQSVPHMVV-DVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFL 299 DV A +++D + + +K+ F A + K G G+ + + D+L Sbjct: 169 DVPAPLIIDMSSNFLSRPITQWEKVGCIF--ACAQKNFGLAGMSVVIIRKDMLERPVKPF 226 Query: 300 GGGEMISDVFLDHS-TYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIG 358 M + + ++ Y PP T AI A + ++ G+ + E Sbjct: 227 CPITMDYRIQVKNNCMYNTPP------TFAIYFANHIFKWIE--EKGGLAAMDALNKEKA 278 Query: 359 KYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSGHHC 418 K +YE + S P+ E R + F +G D LD + + C Sbjct: 279 KKVYEAIDSNPNF--VNRIKPEWRSRMNMPFFRPDGYENKD----LDAD----AKFVNFC 328 Query: 419 AQP-LHRYLG--VNASARASLYFYNTKDDVDAFIVALADTVSFFN 460 Q L G RAS Y + VDA + A+ + F Sbjct: 329 TQRKLLTLKGHVSVGGFRASCYNACPMEAVDALVQAMKEWPGFLE 373 >3BB8-A nrPDB Length = 437 Score = 45.1 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 32/152 (21%), Positives = 61/152 (40%), Gaps = 17/152 (11%) Query: 111 SAKATDEFELA-RKKVARFINASDSREIVFTRNATEAINLVAYSW-----GLSNLKPGDE 164 T F A KK+ ++ ++ T + + A L + G+ LKPGDE Sbjct: 56 GWLTTGRFNDAFEKKLGEYLGVPY---VLTTTSGSSANLLALTALTSPKLGVRALKPGDE 112 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN-EDEVPDINKLRELISPKTKLVAVHHVS 223 VI A + + P + + G + FV ++ + + + +S KTK + + H Sbjct: 113 VITVAAGFPTTVNP----TIQNGLIPVFVDVDIPTYNVNASLIEAAVSDKTKAIMIAH-- 166 Query: 224 NVLASSLPIEEIVVWAHDVGAKVLVDACQSVP 255 L + + E+ A ++ D C ++ Sbjct: 167 -TLGNLFDLAEVRRVADKYNLWLIEDCCDALG 197 >4ZWV-A nrPDB Length = 372 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 75/249 (30%), Gaps = 26/249 (10%) Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN 196 +V + T + L + DEV+ T + G + +V ++ Sbjct: 51 VVSVHSGTSGLCLALRLLDAPEER--DEVLSTPLTFEAT----NWAILADGRRITWVDVD 104 Query: 197 EDEV-PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEI------VVWAHDVGAKVLVD 249 + D++ L ISP T+ + V H + ++ + H V+ D Sbjct: 105 PATLTMDLDDLERKISPATRAIIVVHW---TGYPVDLDRLAGILDRAEREHGFRPAVIED 161 Query: 250 ACQSVP----HMVVDVQKLNADF-LVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEM 304 + + + F A H CG G+ L G +M G + Sbjct: 162 CAHAWGASYRGVPLGSHGNMCVFSFQALKHLTCGDGGLLTLPGDELHERAMLRRFYGIDR 221 Query: 305 ISDVFLDHSTYAEPPSRFEAGTPAIGEAIALG--AAVDYLSGIGMPKIHEYEVEIGKY-L 361 +D Y + + AI L VD + Y+ E+ Sbjct: 222 TADRL--RGAYDVAEWGLKWHMTDLNAAIGLANLETVDEQLRLHRENAAFYDKELTGVPG 279 Query: 362 YEKLSSLPD 370 E L PD Sbjct: 280 LELLQRSPD 288 >4BHD-A nrPDB Length = 428 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 63/394 (15%), Positives = 134/394 (34%), Gaps = 59/394 (14%) Query: 87 AVLDA-LQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 AV +A ++ Y + Y K DE E ++++ + ++ + T Sbjct: 36 AVREACATDFMHRYAEGLPGKRLYQGCKYIDEVETLCIELSKELFKAEHANVQPTSGVVA 95 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQI-VSQKTGAVLKFVTLNEDEV-PDI 203 NL + + KPGD+++ I W++ + G + + +E+ D Sbjct: 96 --NLAVF---FAETKPGDKLMALSVPDGGHISHWKVSAAGIRGLKVINHPFDPEEMNIDA 150 Query: 204 NK-LRELISPKTKLVAVHHVSNVLASS----LPIEEIVVWAHDVGAKVLVDACQS----V 254 + +++++ K KL+ S P+ + A +VGAK+ D Sbjct: 151 DAMVKKILEEKPKLILFG------GSLFPFPHPVADAYEAAQEVGAKIAYDGAHVLGLIA 204 Query: 255 PHMVVDVQKLNADFLVASSHK-MCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHS 313 D + A++L+ S+HK GP G G + + + + G + + Sbjct: 205 GKQFQDPLREGAEYLMGSTHKTFFGPQG-GVILTTKENADKIDSHVFPGVVSNHHLH--- 260 Query: 314 TYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEK----LSSLP 369 G AIAL +++ I + + LYE+ L Sbjct: 261 -------------HKAGLAIALAEMLEFGEAYAKQVIKN-AKALAQALYERGFNVLCEHK 306 Query: 370 DVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRS------GHHCAQPLH 423 D + + F+ ++LA ++ + + ++ ++ P Sbjct: 307 DFT-ESHQVIIDIESSPDIEFS-----ASELAKMYEEANIILNKNLLPWDDVNNSDNPSG 360 Query: 424 RYLGVNASARASLYFYNTKDDVDAFIVALADTVS 457 LG R + +++ F+ +A Sbjct: 361 IRLGTQECTRLGM-KEKEMEEIAEFMKRIAIDKE 393 >1I43-A nrPDB Length = 445 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 56/174 (32%), Gaps = 12/174 (6%) Query: 105 RGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDE 164 R + +K++ A + + A+ + L + G Sbjct: 103 RASFEYGRYGNPTTVVLEEKISALEGAESTLLMASGMCASTVMLLAL-------VPAGGH 155 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSN 224 ++ T + + + + K G + + ++ L K L +N Sbjct: 156 IVTTTDCYRKTRIFIETILPKMGITATVIDPADVGALEL----ALNQKKVNLFFTESPTN 211 Query: 225 VLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCG 278 + IE + H+ GA V +D + P + L AD ++ S+ K G Sbjct: 212 PFLRCVDIELVSKLCHEKGALVCIDGTFATP-LNQKALALGADLVLHSATKFLG 264 >3E77-A nrPDB Length = 377 Score = 44.8 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 70/396 (17%), Positives = 121/396 (30%), Gaps = 64/396 (16%) Query: 82 SQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD---EFELARKKVARFINASDSREIV 138 S P +VL +Q V + +S +++D V + D+ +++ Sbjct: 22 SMLPHSVLLEIQKEL-LDYKGVGISVLEMSHRSSDFAKIINNTENLVRELLAVPDNYKVI 80 Query: 139 FTRNA------TEAINLVAYSWGLSNLKPGDEVIL-----TVAEHHSCIVPWQIVSQKTG 187 F + +NL+ G D V+ AE IV K G Sbjct: 81 FLQGGGCGQFSAVPLNLIGLKAGRC----ADYVVTGAWSAKAAEEAKKFGTINIVHPKLG 136 Query: 188 AVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP-IEEIVVWAHDVGAKV 246 + K +PD + ++P V V I ++ GA + Sbjct: 137 SYTK--------IPDPSTWN--LNPDASYVYYCANETVHGVEFDFIPDV------KGAVL 180 Query: 247 LVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMIS 306 + D + VDV K F A + K G G+ + + DLL G + Sbjct: 181 VCDMSSNFLSKPVDVSKFGVIF--AGAQKNVGSAGVTVVIVRDDLL---------GFALR 229 Query: 307 DVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLS 366 + + + TP +G ++++ G E I Sbjct: 230 ECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKS--QTIYE 287 Query: 367 SLPDVRIYGPRPSESVHRGA-LCSFNVEGLHPTDLAT--FLDQQHGVAIRS--GHHCAQP 421 + + + + P E +R F + D FLD+ + + S GH Sbjct: 288 IIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSV-- 345 Query: 422 LHRYLGVNASARASLYFYNTKDDVDAFIVALADTVS 457 RASLY T +DV + + Sbjct: 346 --------GGIRASLYNAVTIEDVQKLAAFMKKFLE 373 >1E5F-A nrPDB Length = 404 Score = 44.8 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 37/161 (22%), Positives = 64/161 (39%), Gaps = 14/161 (8%) Query: 143 ATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPD 202 AT + + L+ LK GD +I + ++ K G + F+ Sbjct: 82 ATSSGMGAIAATVLTILKAGDHLISDECLYGCTHALFEHALTKFGIQVDFINTAIPG--- 138 Query: 203 INKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDV-GAKVLVDACQSVPHM--VV 259 ++++ + P TK+V +N + +E + AH G V+ D P + V Sbjct: 139 --EVKKHMKPNTKIVYFETPANPTLKIIDMERVCKDAHSQEGVLVIADNTFCSPMITNPV 196 Query: 260 DVQKLNADFLVASSHKMC-GPTGI--GFLYGKSDLLHSMPP 297 D D +V S+ K G T + G + GK+DLL + Sbjct: 197 DF---GVDVVVHSATKYINGHTDVVAGLICGKADLLQQIRM 234 >3WGB-A nrPDB Length = 341 Score = 44.4 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 86/258 (33%), Gaps = 61/258 (23%) Query: 138 VFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVL------K 191 +F + T + L +S+ + G+ +L A H + G+ + + Sbjct: 58 LFVPSGTMSNLLAV----MSHCQRGEGAVLGSAAH-------IYRYEAQGSAVLGSVALQ 106 Query: 192 FVTLNEDEVPDINKLRELISPK------TKLVAVHHVSNVLASSLPI---EEIVVWAHDV 242 V + D + +R I+P T+LV + + N LP+ E+ + Sbjct: 107 PVPMQADGSLALADVRAAIAPDDVHFTPTRLVCLENTHN--GKVLPLPYLREMRELVDEH 164 Query: 243 GAKVLVDACQSVPHMVVD---VQKLNA--DFLVASSHKMCGPTGIGFLYGKSDLLHSMPP 297 G ++ +D + +V V++L A D + K G L G + Sbjct: 165 GLQLHLDGARLFNAVVASGHTVRELVAPFDSVSICLSKGLGAPVGSLLVGSHAFIARARR 224 Query: 298 F--LGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEV 355 + GG M +AG A AL V L+ Sbjct: 225 LRKMVGGGMR-----------------QAGILAQAGLFALQQHVVRLADDHRRARQ---- 263 Query: 356 EIGKYLYEKLSSLPDVRI 373 L E L++LP +R+ Sbjct: 264 -----LAEGLAALPGIRL 276 >3ASB-A nrPDB Length = 400 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 62/404 (15%), Positives = 126/404 (31%), Gaps = 49/404 (12%) Query: 59 KDFRILHQEVNGSKLVYLDSAATS-QKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDE 117 FR+ + + ++ L T+ A+V +A + +S + Sbjct: 24 AQFRLENPQ---HTVINLSIGDTTQPLNASVAEAFASSIARLSSPTTCRGYGPDFGLPAL 80 Query: 118 FELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIV 177 + + R D++EI + A V LS P V + + + + Sbjct: 81 RQKLSEDFYR--GFVDAKEIFISDGAK-----VDLFRLLSFFGPNQTVAIQDPSYPAYLD 133 Query: 178 PWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVV 237 +++ TGA E + E ++ + +N + L +++ Sbjct: 134 ----IARLTGAKEIIALPCLQENAFFPEFPE--DTHIDILCLCSPNNPTGTVLNKDQLRA 187 Query: 238 WAH---DVGAKVLVDACQSV----PHMVVDVQKL-NADFLVASSHKMCGPTGIGFLYGKS 289 H + +L DA S P + + ++ +A F + P G + Sbjct: 188 IVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIPDARFCAIEINSFSKPLGFAGIRLGW 247 Query: 290 DLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPK 349 ++ + G +I D RF + T A A V LS + + Sbjct: 248 TVIPQELTYADGHFVIQDW-----------ERFLSTTFNGASIPAQEAGVAGLSILPQLE 296 Query: 350 IHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHG 409 Y E L + L + ++G + + + + DL F +++ Sbjct: 297 AIHYYRENSDLLRKALLAT-GFEVFGGEHAPYLWVKPTQA----NISDRDLFDFFLREYH 351 Query: 410 VAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALA 453 +AI G G + S ++D+ A L Sbjct: 352 IAITPG--------IGFGRSGSGFVRFSSLGKREDILAACERLQ 387 >1U08-A nrPDB Length = 386 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 55/137 (40%), Gaps = 20/137 (14%) Query: 105 RGIHYLSAKATDE-----FELARKKVA----RFINASDSRE--IVFTRNATEAINLVAYS 153 R H+++ A + R+ +A R + I T ATEA+ Y+ Sbjct: 51 RLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEAL----YA 106 Query: 154 WGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISP 212 + ++ GDEVI + S P +G ++K + L D + L+S Sbjct: 107 AITALVRNGDEVICFDPSYDS-YAP---AIALSGGIVKRMALQPPHFRVDWQEFAALLSE 162 Query: 213 KTKLVAVHHVSNVLASS 229 +T+LV ++ N A+ Sbjct: 163 RTRLVILNTPHNPSATV 179 >1PFF-A nrPDB Length = 331 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 115/338 (34%), Gaps = 43/338 (12%) Query: 141 RNATEAINLVAYSWGL-SNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE 199 A A + A + + + LK GD +I + ++ +K G + F+ + Sbjct: 15 ACAATASGMGAIAASVWTFLKAGDHLISDDCLYGCTHALFEHQLRKFGVEVDFIDMAVPG 74 Query: 200 VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAH-DVGAKVLVDACQSVPHM- 257 + + + P T++V +N + IE+ V A V+VD + P + Sbjct: 75 -----NIEKHLKPNTRIVYFETPANPTLKVIDIEDAVKQARKQKDILVIVDNTFASPILT 129 Query: 258 -VVDVQKLNADFLVASSHKMC-GPTGI--GFLYGKSDLLHSMPPFLGGGEMISDVFLDHS 313 +D L D +V S+ K G T + G + ++D++ + + I D+ Sbjct: 130 NPLD---LGVDIVVHSATKYINGHTDVVAGLVCSRADIIAKVKS-----QGIKDIT---G 178 Query: 314 TYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRI 373 P + + + + A + K+ E+ E LPD Sbjct: 179 AIISPHDAWLITRGTLTLDMRVKRAAE-----NAQKVAEFLHEHKAVKKVYYPGLPDHPG 233 Query: 374 YGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIRSG------------HHCAQP 421 + + G++ +F+V+GL +A+ G H P Sbjct: 234 HEIAKKQMKMFGSMIAFDVDGLEKAKKVLDNCHVVSLAVSLGGPESLIQHPASMTHAGVP 293 Query: 422 LHRYLGV---NASARASLYFYNTKDDVDAFIVALADTV 456 + R S+ N +D +D AL + Sbjct: 294 KEEREAAGLTDNLIRLSVGCENVQDIIDDLKQALDLVL 331 >1BJO-A nrPDB Length = 360 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 76/223 (34%), Gaps = 31/223 (13%) Query: 82 SQKPAAVLDALQNYYEFYNS---NVHRGIHYLSAKATDEFELARKKVARFINASDSREIV 138 + PA VL Q +N +V H + E A K +N + +++ Sbjct: 10 AMLPAEVLKQAQQELRDWNGLGTSVMEVSHR-GKEFIQVAEEAEKDFRDLLNVPSNYKVL 68 Query: 139 FTRN------ATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 F A +N++ + G + E P A + Sbjct: 69 FCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKYCTPNVF-----DAKVTV 123 Query: 193 VTLNEDEVPDINKLREL-ISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLV--D 249 D + + +RE +S +H+ N + I+E D GA V+V D Sbjct: 124 -----DGLRAVKPMREWQLSDNAAY--MHYCPNETIDGIAIDE----TPDFGADVVVAAD 172 Query: 250 ACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLL 292 ++ +DV + + A + K GP G+ + + DLL Sbjct: 173 FSSTILSRPIDVSRYGVIY--AGAQKNIGPAGLTIVIVREDLL 213 >3ELE-A nrPDB Length = 398 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 105/330 (31%), Gaps = 46/330 (13%) Query: 68 VNGSKLVYLD---SAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKK 124 + G + VY D + P V D ++ Y+S +H ++ D R Sbjct: 31 IVGKENVY-DFSIGNPSIPAPQIVNDTIKELVTDYDS---VALHGYTSAQGDV--ETRAA 84 Query: 125 VARFINASDS-----REIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPW 179 +A F+N + + T A ++++ + DE I + Sbjct: 85 IAEFLNNTHGTHFNADNLYMTMGAAASLSICFRALTSD---AYDEFITIAP----YFPEY 137 Query: 180 QIVSQKTGAVLKFVTLNEDE-VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVW 238 ++ GA L V + + D + L E I+ T+ V ++ +N + E I Sbjct: 138 KVFVNAAGARLVEVPADTEHFQIDFDALEERINAHTRGVIINSPNNPSGTVYSEETIKKL 197 Query: 239 -------AHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDL 291 + ++G + + P+ + + F+ K T + + Y KS Sbjct: 198 SDLLEKKSKEIGRPIFI--IADEPYREIVYDGIKVPFVT----KYYDNTLVCYSYSKSLS 251 Query: 292 LHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIH 351 L GE I V + Y + A G A+ A + + K Sbjct: 252 LP--------GERIGYVLVPDEVYDKAE--LYAAVCGAGRALGYVCAPSLFQKM-IVKCQ 300 Query: 352 EYEVEIGKYLYEKLSSLPDVRIYGPRPSES 381 +I Y + + G + Sbjct: 301 GATGDINAYKENRDLLYEGLTRIGYHCFKP 330 >3H7F-A nrPDB Length = 447 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 76/230 (33%), Gaps = 18/230 (7%) Query: 84 KPAAVLDALQNYYEFYNSN--VHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTR 141 P AVL A + + R + LAR + A + V Sbjct: 57 VPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFAN--VQPH 114 Query: 142 NATEAINLVAYSWGLSNLKPGDEVI---LTVAEHHSCIVPWQIVSQKTGAVLKFVTLNED 198 + +A V ++ + PG+ ++ L H + + + V Sbjct: 115 SGAQANAAVLHAL----MSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATH 170 Query: 199 EVPDINKLRE-LISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM 257 + D++ +R + + K++ + L A +VGAK+LVD + Sbjct: 171 -LIDMDAVRATALEFRPKVIIAGWSAYP--RVLDFAAFRSIADEVGAKLLVDMAHFAGLV 227 Query: 258 VVDVQKL---NADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEM 304 + +AD + + HK G G + GK ++ + G+ Sbjct: 228 AAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQ 277 >4AOA-A nrPDB Length = 454 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 49/262 (18%), Positives = 95/262 (36%), Gaps = 36/262 (13%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSR--EIVFTRNA 143 AV++A+Q N+ G ++AR I + ++ FT + Sbjct: 110 DAVIEAMQGGINLTGHNLLEG-----------------RLARLICERFPQIEQLRFTNSG 152 Query: 144 TEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDI 203 TEA NL+A + L ++++ +H ++ + T F+ L ++ Sbjct: 153 TEA-NLMALTAALHFTGR-RKIVVFSGGYHGGVLGFGARPSPTTVPFDFLVLPYNDAQTA 210 Query: 204 NKLRELISPKTKLVAVHHVSNVLASS--LP--IEEIVVWAHDVGAKVLVDACQS---VPH 256 E P+ +V V + P ++ + A VGA ++ D + PH Sbjct: 211 RAQIERHGPEIAVVLVEPMQGASGCIPGQPDFLQALRESATQVGALLVFDEVMTSRLAPH 270 Query: 257 MVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSM----PPFLGGGEMISDVFLDH 312 + + + +D + + G G G++D++ P G ++V Sbjct: 271 GLANKLGIRSDLTTLGKY-IGGGMSFGAFGGRADVMALFDPRTGPLAHSGTFNNNVMTMA 329 Query: 313 STYAEPPSRFEAGTPAIGEAIA 334 + YA F TP A+A Sbjct: 330 AGYAGLTKLF---TPEAAGALA 348 >5YHV-A nrPDB Length = 394 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 85/327 (25%), Gaps = 52/327 (15%) Query: 107 IHYLSAKATDEFELARKKVARFINASD-----SREIVFTRNATEAINLVAYSWGLSNLKP 161 ++ L R +A +V T ++ L + Sbjct: 65 LNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLAC----FDA 120 Query: 162 GDEVILTVAEHHSCIVPWQI-VSQKTGAVLKFVTLNEDEVPD-INKLRELISPKTKLVAV 219 GD V + + P + G + + ++ I P + V V Sbjct: 121 GDRVAMASPGY-----PCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEIDPPLRGVVV 175 Query: 220 HHVSNVLASSLPIEEIVVWAHDVGA---KVLVDAC------QSVPHMVVDVQKLNADFLV 270 +N + +P EE+ A A +++ D Q P Q +V Sbjct: 176 ASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQTSRNAVVV 235 Query: 271 ASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIG 330 S K TG + G ++ V F P + Sbjct: 236 NSFSKYYAMTG----------------WRLGWLLVPTVLRRAVDCLTG--NFTICPPVLS 277 Query: 331 EAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSF 390 + A+ A E + + Y + L +R G Sbjct: 278 QIAAVSA-------FTPEATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYA 330 Query: 391 NVEGLHPTDLA--TFLDQQHGVAIRSG 415 +V LA + L GVAI G Sbjct: 331 DVSDFTSDSLAFCSKLLADTGVAIAPG 357 >3NRA-A nrPDB Length = 407 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 46/302 (15%), Positives = 98/302 (32%), Gaps = 51/302 (16%) Query: 54 GHRVRKDFRILHQEVNGSKL-------VYLDSAATSQKPAAVLDALQNYYEFYNSNVHRG 106 G VR+ L + G+ + + D A P A ++ +++ V G Sbjct: 18 GQEVRQSAAGLEALIRGAPIEGRPVDFSHGDVDAHEPTPGA--------FDLFSAGVQSG 69 Query: 107 ---IHYLSAKATDEFELARKKVARFINASDS--REIVFTRNATEAINLVAYSWGLSNLKP 161 + +L ++A F A ++ T A+ L + + Sbjct: 70 GVQAYTEYRGDLGIRDLLAPRLAAFTGAPVDARDGLIITPGTQGALFLAV----AATVAR 125 Query: 162 GDEVILTVAEHHSCIVPWQIVSQKTG-AVLKFVTLNEDEV-PDINKLRELISPKTKLVAV 219 GD+V + ++ + + + L +V+ +E D+ L E ++ Sbjct: 126 GDKVAIVQPDYFANRKLVEFFEGEMVPVQLDYVSADETRAGLDLTGLEEAFKAGARVFLF 185 Query: 220 HHVSNVLASSLPIEEIV---VWAHDVGAKVLVD--------ACQSVPHMVVDVQKLNADF 268 + +N EEI A GA V+ D A S H+ + ++A+ Sbjct: 186 SNPNNPAGVVYSAEEIGQIAALAARYGATVIADQLYSRLRYAGASYTHLRAE-AAVDAEN 244 Query: 269 L----------VASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEM---ISDVFLDHSTY 315 + S +++ G + + + L ++ G + F + + Sbjct: 245 VVTIMGPSKTESLSGYRLGVAFGSRAIIARMEKLQAIVSLRAAGYSQAVLRGWFDEAPGW 304 Query: 316 AE 317 E Sbjct: 305 ME 306 >5U24-A nrPDB Length = 382 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 59/143 (41%), Gaps = 14/143 (9%) Query: 119 ELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVP 178 E A++ + N +A+ L+ ++ + K DE+I+ + + I Sbjct: 59 EKFENNFAKYCGVKH---CIGVANGLDALRLIIKAY---DFKENDEIIVPANTYIASI-- 110 Query: 179 WQIVSQKTGAVLKFVTLNEDEV-PDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVV 237 I K +L +N + PD+ + E I+ KTK + V H+ +E+I + Sbjct: 111 LAITDNKCKPILIEPDINTYNINPDL--IEEKITKKTKAIMVVHL---YGQVCDMEKIQL 165 Query: 238 WAHDVGAKVLVDACQSVPHMVVD 260 A+ K++ D Q+ + D Sbjct: 166 LANKYNLKIIEDCAQAHGAIYKD 188 >1YJS-A nrPDB Length = 419 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 82/235 (34%), Gaps = 25/235 (10%) Query: 86 AAVLDALQNYYEFYNSN--VHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNA 143 AV++A + + R + ELAR++ + A + V + Sbjct: 37 RAVMEAQGSVLTNKYAEGYPGRRYYGGCEYVDIVEELARERAKQLFGAEHAN--VQPHSG 94 Query: 144 TEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIV---PWQIVSQKTGAVLKFVTLNEDEV 200 +A N+ Y + L+ GD V+ H + P + V V V Sbjct: 95 AQA-NMAVY---FTVLEHGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVAYGVDPETH-V 149 Query: 201 PDINKLRELIS-PKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVV 259 D + +RE + KL + ++ + + A +VGA ++VD + Sbjct: 150 IDYDDVREKARLHRPKL--IVAAASAYPRIIDFAKFREIADEVGAYLMVDMAHIAGLVAA 207 Query: 260 DVQKLN---ADFLVASSHK-MCGPTGIGFLYGKSDLLHSM-----PPFLGGGEMI 305 + A F+ ++H+ + GP G G + + + P GG M Sbjct: 208 GLHPNPVPYAHFVTTTTHQTLRGPRG-GMILCQEQFAKQIDKAIFPGIQGGPLMH 261 >3LY1-A nrPDB Length = 354 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 16/121 (13%), Positives = 45/121 (37%), Gaps = 12/121 (9%) Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN 196 I+ T ++E I ++ + +++ + ++ G + V + Sbjct: 71 ILLTAGSSEGIRAAIEAYASLEAQ----LVIPELT----YGDGEHFAKIAGMKVTKVKML 122 Query: 197 EDEVPDINKLRELISPKT--KLVAVHHVSNVLASSLPIEEIVVW--AHDVGAKVLVDACQ 252 ++ DI L+ ++ + +V + + +N + P + I W + +VD Sbjct: 123 DNWAFDIEGLKAAVAAYSGPSIVYLVNPNNPTGTITPADVIEPWIASKPANTMFIVDEAY 182 Query: 253 S 253 + Sbjct: 183 A 183 >1LC8-A nrPDB Length = 364 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 80/258 (31%), Gaps = 43/258 (16%) Query: 137 IVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLN 196 I+ TE+I VA LKP +I+T + ++G ++ +L Sbjct: 79 ILAGNGETESIFTVASG-----LKPRRAMIVTPG-----FAEYGRALAQSGCEIRRWSLR 128 Query: 197 EDEVPDI-NKLRELISPKTKLVAVHHVSNVLASSLP---IEEIVVWAHDVGAKVLVDAC- 251 E + + + + E ++P + + +N ++ I + +++D Sbjct: 129 EADGWQLTDAILEALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAF 188 Query: 252 -----QSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMIS 306 + ++ +++ S K G+ Y + Sbjct: 189 IDFIPHETGFIPA-LKDNPHIWVLRSLTKFYAIPGLRLGYLVNS---------------D 232 Query: 307 DVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLS 366 D + + P ++ AL V + E G Y+ L Sbjct: 233 DAAMARMRRQQMPW-------SVNALAALAGEVALQDSAWQQATWHWLREEGARFYQALC 285 Query: 367 SLPDVRIYGPRPSESVHR 384 LP + +Y R + + R Sbjct: 286 QLPLLTVYPGRANYLLLR 303 >1WYT-A nrPDB Length = 438 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 107/331 (32%), Gaps = 40/331 (12%) Query: 141 RNATEAINLVAYSWGLSNLKPGD-EVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE 199 AT +A L+ + G V+++ H + + GA L + L Sbjct: 132 DGAT----ALAEGVLLALRETGRMGVLVSQGVHPEYRAVLRAYLEAVGAKLLTLPLEGGR 187 Query: 200 VPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVV 259 P E+ + V N L + + AH GA + A ++ Sbjct: 188 TPLPEVGEEVGA------VVVQNPNFLGALEDLGPFAEAAHGAGALFVAVADPLSLGVLK 241 Query: 260 DVQKLNADFLVASSHKMCGPTGIG-----FLYGKSDLLHSMP--------PFLGGGEMIS 306 AD V + P G G FL K + +P G I Sbjct: 242 PPGAYGADIAVGDGQSLGLPMGFGGPHFGFLATKKAFVRQLPGRLVSETVDVEGRRGFIL 301 Query: 307 DVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLS 366 + ++ T A A+ + L G+ ++ VE+ L+ L Sbjct: 302 TLQAREQYIRRAKAKSNITTNAQLTALMGAMYLAALGPEGLREVALKSVEMAHKLHALLL 361 Query: 367 SLPDVRIYGPRPSESVHRGALCSFNVE-GLHPTDLATFLDQQHGVAIRSGHHCAQPLHRY 425 +P VR + P+P F + P + L ++ G H A P+ R Sbjct: 362 EVPGVRPFTPKPF-------FNEFALALPKDPEAVRRALAER-------GFHGATPVPRE 407 Query: 426 LGVNASARASLYFYNTKDDVDAFIVALADTV 456 G N + A+ + ++D+ A AL + + Sbjct: 408 YGENLALFAATELHE-EEDLLALREALKEVL 437 >2C81-A nrPDB Length = 418 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 54/153 (35%), Gaps = 16/153 (10%) Query: 106 GIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEV 165 ++ ++ E K N + T +T A+ L + G + GDEV Sbjct: 34 SGYWTGEES---MERKFAKAFADFNGV-PYCVPTTSGST-ALMLALEALG---IGEGDEV 85 Query: 166 ILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE-VPDINKLRELISPKTKLVAVHHVSN 224 I+ + A+ FV + D D ++ I+ KTK + H+ Sbjct: 86 IVPSLTWIATAT----AVLNVNALPVFVDVEADTYCIDPQLIKSAITDKTKAIIPVHL-- 139 Query: 225 VLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM 257 S ++EI A + V+ D QS + Sbjct: 140 -FGSMANMDEINEIAQEHNLFVIEDCAQSHGSV 171 >2DOU-A nrPDB Length = 376 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 30/186 (16%), Positives = 67/186 (36%), Gaps = 18/186 (9%) Query: 70 GSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFI 129 G L+ L +T P +A ++ + L + E A + Sbjct: 24 GVGLIDLSIGSTDLPPP---EAPLKALAEALNDPTTYGYCLKSCTLPFLEEAARWYEGRY 80 Query: 130 N-ASDSR-EIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTG 187 D R E + + E + + + +P D ++L + P + + Sbjct: 81 GVGLDPRREALALIGSQEGLAHLLLALT----EPEDLLLLPEVAY-----PSYFGAARVA 131 Query: 188 AVLKF-VTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLP---IEEIVVWAHDVG 243 ++ F + L ED + D+ + E + + K++ +++ +N + EE + A G Sbjct: 132 SLRTFLIPLREDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYFEEALGLARKHG 191 Query: 244 AKVLVD 249 ++ D Sbjct: 192 LWLIHD 197 >4MY5-A nrPDB Length = 393 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 33/182 (18%), Positives = 63/182 (34%), Gaps = 30/182 (16%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINAS------DSREIV 138 P + +A + + S HY R+ + F+ EI+ Sbjct: 47 PKHIKEAAKRAIDADES------HYTGM---AGLLALRQAASAFVKEKYHLTYNPDNEIL 97 Query: 139 FTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNED 198 T ATEA++ + L+PGD+V+L + ++ V GA + + + Sbjct: 98 VTIGATEALSASLTAI----LEPGDKVLLPAPAYPG----YEPVVNLVGAEVVEIDTRSN 149 Query: 199 E-VPDINKLRELI---SPKTKLVAVHHVSNVLASS---LPIEEIVVWAHDVGAKVLVDAC 251 + V L E I K V +++ +N + I+ + V+ D Sbjct: 150 DFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKYPIFVISDEV 209 Query: 252 QS 253 + Sbjct: 210 YA 211 >4OC9-A nrPDB Length = 424 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 4/103 (3%) Query: 196 NEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP 255 E ++ D++ L ++I TK + +SN + IE+I A + D + P Sbjct: 128 REFDIDDLDSLEKVIDQNTKAIFFESLSNPQIAIADIEKINQIAKKHKIVSICDNTVATP 187 Query: 256 HMVVDVQKLNADFLVASSHKM---CGPTGIGFLYGKSDLLHSM 295 ++ K D +V S K G G L + DL + Sbjct: 188 FLLQPF-KHGVDVIVHSLSKYVSGQGTALGGALIERKDLNDLL 229 >3PJ0-A nrPDB Length = 359 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 51/337 (15%), Positives = 100/337 (29%), Gaps = 48/337 (14%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 + L + + N+ I+ E K+A+ + + VF + T Sbjct: 22 PRNVGVLTEALQNIDDNLESDIYGNG----AVIEDFETKIAKILGKQSA---VFFPSGTM 74 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAV--LKFVTL---NEDEV 200 A + W + K V H + ++ G + L +++ Sbjct: 75 AQQIALRIWA--DRKENRRVAYHPLSH-------LEIHEQDGLKELQQITPLLLGTANQL 125 Query: 201 PDINKLRELISPKTKLVAVHHVSNVLASSLP----IEEIVVWAHDVGAKVLVDACQSVPH 256 I+ ++ + V + + LP +E+I + H+ G + +D + Sbjct: 126 LTIDDIKS-LREPVSSVLIELPQREIGGQLPAFEELEKISEYCHEQGISLHLDGARLWEI 184 Query: 257 MVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYA 316 F S+ ++C L+ + S +GG D Sbjct: 185 TP---------FYQKSAEEIC------ALF--DSVYVSFYKGIGGIAGAILAGNDDFVQE 227 Query: 317 EPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGP 376 + G I + +A DY + K+ EY E+ +S V+ Sbjct: 228 AKIWKRRYGGDLISLYPYILSA-DYYFEKRIGKMAEYFEAAKGLA-ERFNSCSGVKTV-- 283 Query: 377 RPSESVHRGALCSFNVEGLHPTDLATFLDQQHGVAIR 413 P V F + T + + GV I Sbjct: 284 -PEVPVSNMFHVYFENSADEIGAILTKIQDETGVGIS 319 >2QMA-A nrPDB Length = 497 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 59/189 (31%), Gaps = 40/189 (21%) Query: 111 SAKATDEFELARKKVARFINASDSREIVFTRNATEAINL----------------VAYSW 154 ++ AT + + + S+ + +FT T++ + Sbjct: 135 ASSATYVEQKVVNWLCDKYDLSEKADGIFTSGGTQSNQMGLMLARDWIADKLSGHSIQKL 194 Query: 155 GLSNLKPGDEVILTVAEHHSCI--VPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISP 212 GL + ++ + H + W + +K + N D DI KL E+I+ Sbjct: 195 GLPDYADKLRIVCSKKSHFTVQKSASWMGLGEKAVMTVD---ANADGTMDITKLDEVIAQ 251 Query: 213 KTK--LV--AVHHVSNVL--ASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNA 266 L+ A+ + + ++ I A + VD Sbjct: 252 AKAEGLIPFAIVGTAGTTDHGAIDDLDFIADMAVKHDMWMHVDGAYGGA----------- 300 Query: 267 DFLVASSHK 275 L+ SSHK Sbjct: 301 --LILSSHK 307 >3TQX-A nrPDB Length = 399 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 58/175 (33%), Gaps = 18/175 (10%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 A++ Q E Y + + + K ++ F+ D I+++ + Sbjct: 60 PALIKTAQTVVEQYGFGMASVRFICGTQT--IHKELEKDISEFLGTDD--TILYSSCF-D 114 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINK 205 A + L P D +I H S I ++ + + + D+ Sbjct: 115 ANG----GLFETLLGPEDAIISDELNHASIIDGIRL------CKAQRYRYKNNAMGDLEA 164 Query: 206 LRELISPKT---KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHM 257 + K KL+A V ++ ++ I A A V+VD +V + Sbjct: 165 KLKEADEKGARFKLIATDGVFSMDGIIADLKSICDLADKYNALVMVDDSHAVGFI 219 >2JIS-A nrPDB Length = 515 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 61/184 (33%), Gaps = 28/184 (15%) Query: 117 EFELARKKVARFINASDSREIVFTRNATEAI----NLVAYSWGLSNLKPGDEVI------ 166 E +K+ + S I F + + NL Y + G + Sbjct: 149 MEEEVLRKLRALVGWSSGDGI-FCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALF 207 Query: 167 LTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTK------LVAVH 220 + H+S + T + ++ V +E L I LV+ Sbjct: 208 TSKECHYSIQKGAAFLGLGTDS-VRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSAT 266 Query: 221 HVSNVLASSLPIEEIVVWAHDVGAKVLVDAC--------QSVPHMVVDVQKLNADFLVAS 272 + VL + P+E I G + VDA Q+ H++ +Q+ AD + + Sbjct: 267 SGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQR--ADSVAWN 324 Query: 273 SHKM 276 HK+ Sbjct: 325 PHKL 328 >1M4N-A nrPDB Length = 435 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 45/132 (34%), Gaps = 18/132 (13%) Query: 133 DSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKF 192 D +V T AT A + PG+ V++ + + +TG + Sbjct: 110 DPNHLVLTAGATSANETFIFCLA----DPGEAVLIPTPYYPGFDRDLKW---RTGVEIVP 162 Query: 193 VTLNEDEVPDINK--LRELISP------KTKLVAVHHVSNVLASSLPIEEIVVW---AHD 241 + I + L E + K V V + SN L +++ E+ + D Sbjct: 163 IHCTSSNGFQITETALEEAYQEAEKRNLRVKGVLVTNPSNPLGTTMTRNELYLLLSFVED 222 Query: 242 VGAKVLVDACQS 253 G ++ D S Sbjct: 223 KGIHLISDEIYS 234 >5VNX-A nrPDB Length = 393 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 35/198 (17%), Positives = 75/198 (37%), Gaps = 19/198 (9%) Query: 65 HQEVNGSKLVYL---DSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELA 121 H VNG ++V D + P V + + + + + ++A + E Sbjct: 33 HMTVNGREIVGFASNDYLGLAAHPKLVAAFAEGAQRYGSGSGGSHLLGGHSRAHAKLE-- 90 Query: 122 RKKVARFINASD--SREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPW 179 ++A F R + F+ +A ++ L D I + A +H+ ++ Sbjct: 91 -DELAGFAGGFSDAPRALYFSTG------YMANLAAVTALAGKDATIFSDALNHASLIDG 143 Query: 180 QIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWA 239 +S+ A ++ + + L E + +TKL+ V ++ P+ E++ A Sbjct: 144 TRLSR---ATVQVYP--HADTATLGALLEACTSQTKLIVTDTVFSMDGDIAPLAELLALA 198 Query: 240 HDVGAKVLVDACQSVPHM 257 GA ++VD + Sbjct: 199 ERHGAWLVVDDAHGFGVL 216 >6EEQ-A nrPDB Length = 490 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 62/196 (31%), Gaps = 30/196 (15%) Query: 109 YLSAKATDEFELARKKVARFINASDS------REIVFTRNATEAINLVAYSWGLSNL--K 160 S AT+ + +A+ +N S V N EA+ L + + Sbjct: 122 SSSPAATELENVVVDWMAKMLNLPSSFCFSGGGGGVLQANTCEAV-LCTLAAARDKALNR 180 Query: 161 PGDE-----VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDI--NKLRELISPK 213 GD+ V+ + H I + +K +T ++ + N LR+ I Sbjct: 181 VGDDQINKLVLYCSDQTHFTIHKGAKLIGIRSKNIKSITTKKENEFKLCPNDLRDAIRSD 240 Query: 214 T------KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP-------HMVVD 260 V + L PI+E+ A + + VD +D Sbjct: 241 LEAGLVPFYVCGTIGTTALGVVDPIKELGKVAREFDLWLHVDGAYGGSACICPEFQHYLD 300 Query: 261 VQKLNADFLVASSHKM 276 L D + ++HK Sbjct: 301 GVDL-VDSISMNAHKW 315 >3IHJ-A nrPDB Length = 498 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 26/155 (16%), Positives = 60/155 (38%), Gaps = 20/155 (12%) Query: 111 SAKATDEFELARKKVARFINASD------SREIVFTRNATEAINLVAYSWGLSNLKPGDE 164 S A+ R+ VA +I D I T A++ I+ + K Sbjct: 124 SYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTG 183 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDE--VPDINKLRELISP-----KTKLV 217 V++ + ++ + ++S+ + + L+E+ ++N+LR + K++ Sbjct: 184 VMIPIPQY---PLYSAVISELDAIQVNYY-LDEENCWALNVNELRRAVQEAKDHCDPKVL 239 Query: 218 AVHHVSNVLASSLP---IEEIVVWAHDVGAKVLVD 249 + + N IE+++ +A + +L D Sbjct: 240 CIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 274 >4RIT-B nrPDB Length = 486 Score = 37.4 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 84/283 (29%), Gaps = 46/283 (16%) Query: 124 KVARFINASDSREIVFTRNATEAIN---LVAYSWGLSNLKPG------DEVILTVAEHHS 174 +A + V T + A VA + +++PG VI H+ Sbjct: 135 AIAGLFGLGEQAGGVLTSGGSLANLQALAVARNVAFDSVEPGITGLAQRPVIFASEAAHT 194 Query: 175 CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISP------KTKLVAVHHVSNVLAS 228 + ++ A + V D D LR I V + + Sbjct: 195 SLQKAAMLLGLGTAAVIPVRATADSRMDPEDLRARIDQARGAGQHPFCVVATAGTTTTGN 254 Query: 229 SLPIEEIVVWAHDVGAKVLVDACQSVPHMVVD---------VQKLNADFLVASSHKMCGP 279 P+ EI A + G VDA +V +++ AD + + K Sbjct: 255 IDPLAEIGAIAREHGLWFHVDAAYG-GALVFSERHRWRLAGIEQ--ADSITFNPQKW--- 308 Query: 280 TGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHS-TYAEPPSRF----EAGTPAIGEA-- 332 LY + + L + + Y F E G A Sbjct: 309 -----LY----VAKTCAMVLFRDAGVLERAFRIPAPYMRATDGFINLGEIGVQGTRHADV 359 Query: 333 IALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYG 375 + L + ++ G ++ + + + + E + P +R+ G Sbjct: 360 VKLWLTLQHIGQQGYARLIDDGYRLAERVVEGVRQRPFLRLAG 402 >6ENZ-A nrPDB Length = 530 Score = 37.0 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 49/152 (32%), Gaps = 20/152 (13%) Query: 117 EFELARKKVARFINASDSREIVFTRNATEAI----NLVAYSWGLSNLKPG-----DEVIL 167 E KK+ + + I F + + NL Y + G ++ Sbjct: 164 VEEAVLKKMIECVGWKEGDGI-FNPGGSVSNMCAMNLARYRHCPDIKEKGLSGLPRLILF 222 Query: 168 TVAE-HHSCIVPWQIVSQKTGAV-LKFVTLNEDEVPDINKLRELISPKTK------LVAV 219 T AE H+S + G + FV + L + I + LV Sbjct: 223 TSAECHYSMKKAASFLG--IGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCA 280 Query: 220 HHVSNVLASSLPIEEIVVWAHDVGAKVLVDAC 251 + VL + P++EI G + VDA Sbjct: 281 TSGTTVLGAFDPLDEIAEVCERHGLWLHVDAS 312 >1IAY-A nrPDB Length = 428 Score = 37.0 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 21/153 (13%), Positives = 56/153 (36%), Gaps = 29/153 (18%) Query: 122 RKKVARFI----NAS---DSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHS 174 RK +A+F+ D +V AT A + + PGD ++ + + Sbjct: 89 RKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLA----DPGDAFLVPSPYYPA 144 Query: 175 CIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISP----------KTKLVAVHHVSN 224 + +TG ++ + ++ + + + + K K + + + SN Sbjct: 145 FNRDLRW---RTG--VQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKVKGLILTNPSN 199 Query: 225 VLASSLP---IEEIVVWAHDVGAKVLVDACQSV 254 L ++L ++ ++ + + ++ D + Sbjct: 200 PLGTTLDKDTLKSVLSFTNQHNIHLVCDEIYAA 232 >5JAY-A nrPDB Length = 402 Score = 36.7 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 54/404 (13%), Positives = 121/404 (29%), Gaps = 62/404 (15%) Query: 65 HQEVNGSKLVYL---DSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELA 121 H V+G ++ D + P + + + + + ++A + E Sbjct: 41 HMTVDGRAIIGFASNDYLGLAAHPQLIAAIAEGAQRYGAGSGGSHLLGGHSRAHAQLE-- 98 Query: 122 RKKVARFINA--SDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPW 179 +A F+ ++R + F+ + + + G + H S I Sbjct: 99 -DDLAEFVGGFVENARALYFSTGY-----MANLATLTALAGRGTTLFSDALNHASLIDGA 152 Query: 180 QIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWA 239 ++ A ++ + ++ + E K++ V ++ P+ ++ A Sbjct: 153 RLSR----ADVQIYP--HCDTDALSAMLEASDADVKVIVSDTVFSMDGDIAPLPRLLELA 206 Query: 240 HDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFL---------YGKSD 290 GA ++VD + GP G G + Sbjct: 207 EQHGAWLIVDDAHGFGVL--------------------GPQGRGAIAQAALRSPNLISIG 246 Query: 291 LLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKI 350 L G + ++ P F + A A+ A++ + G Sbjct: 247 TLDKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVP-AAAHAVSASLRIIGGEEGDAR 305 Query: 351 HEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATFLDQQHGV 410 + ++ L + P + P S + + + N L +A LD+ G+ Sbjct: 306 RAHLQQLIGRTRAMLKATPWL----PVDSHTAVQPLIIGANDATLE---IAATLDRA-GL 357 Query: 411 AIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALAD 454 + + P + R SL +++ D+D L Sbjct: 358 WVPAIRPPTVPT-----GTSRLRISLSAAHSQADLDRLEAGLQQ 396 >6F77-B nrPDB Length = 400 Score = 36.7 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 37/196 (18%), Positives = 69/196 (35%), Gaps = 25/196 (12%) Query: 48 SESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGI 107 S ++++ + R+ + ++V G D A +DA+ Y GI Sbjct: 14 SATIAVSQKARE-LKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGETKY--TPVSGI 70 Query: 108 HYLSAKATDEFELARK---KVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDE 164 L +F+ A+ I + ++I+F ++ L PGDE Sbjct: 71 PELREAIAKKFKRENNLDYTAAQTIVGTGGKQILFNA-------------FMATLNPGDE 117 Query: 165 VILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDI--NKLRELISPKTKLVAVHHV 222 V++ V + + G FV ++ + L I+PKTK + Sbjct: 118 VVIPAP----YWVSYPEMVALCGGTPVFVPTRQENNFKLKAEDLDRAITPKTKWFVFNSP 173 Query: 223 SNVLASSLPIEEIVVW 238 SN ++ EE+ Sbjct: 174 SNPSGAAYSHEELKAL 189 >3PGY-A nrPDB Length = 415 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 87/249 (34%), Gaps = 28/249 (11%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLS----AKATDEFELARKKVARFINASDSREIVFTR 141 AV++A + + + G Y T+ + R K A V Sbjct: 40 EAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKA--LFGAEHVN--VQPH 95 Query: 142 NATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIV---PWQIVSQKTGAVLKFVTLNED 198 + +A N+ Y L+ GD V+ H + P + V V + + Sbjct: 96 SGPQA-NMAVYLVA---LEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTE 151 Query: 199 EVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQ-----S 253 + + + K KL+ V S + ++ A +V AK++VD + Sbjct: 152 RINYDEVRKLALEHKPKLI-VAGASAYSRTI-DFKKFKEIADEVNAKLMVDMAHIAGLVA 209 Query: 254 VPHMVVDVQKLNADFLVASSHK-MCGPTGIGFLYG---KSDLLHSMPPFLGGGEMISDVF 309 V+ ADF+ ++HK + GP G L K D+ ++ P + GG + + Sbjct: 210 AGLHPNPVEY--ADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIA 267 Query: 310 LDHSTYAEP 318 + E Sbjct: 268 AKAVAFGEA 276 >3NX3-A nrPDB Length = 395 Score = 36.7 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 38/249 (15%), Positives = 72/249 (28%), Gaps = 38/249 (15%) Query: 135 REIVFTRNATEAINLVAYS---WGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLK 191 + FT + TE+I + + + G + I H + ++ Sbjct: 94 ERVFFTNSGTESIEGAMKTARKYAFNKGVKGGQFIAFKHSFHGRTLGALSLTANEKYQKP 153 Query: 192 FVTLNEDEVP----DINKLRELISPKTKLVAVHHVSNVLASSLPI-----EEIVVWAHDV 242 F L DI+ + +L++ KT + + V P + + + Sbjct: 154 FKPLISGVKFAKYNDISSVEKLVNEKTCAIILESVQGE-GGINPANKDFYKALRKLCDEK 212 Query: 243 GAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGG 302 ++ D Q G +G F Y + +L + Sbjct: 213 DILLIADEIQCGM----------------------GRSGKFFAYEHAQILPDIMTSAKAL 250 Query: 303 EMISDVFLDHSTYAEPPSRFEAGTPA--IGEAIALGAAVDYLSGIGMPK-IHEYEVEIGK 359 V + EAG G + A V+ + I + I E ++ Sbjct: 251 GCGLSVGAFVINQKVASNSLEAGDHGSTYGGNPLVCAGVNAVFEIFKEEKILENVNKLTP 310 Query: 360 YLYEKLSSL 368 YL + L L Sbjct: 311 YLEQSLDEL 319 >6ONN-A nrPDB Length = 402 Score = 36.7 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 30/201 (14%), Positives = 61/201 (30%), Gaps = 25/201 (12%) Query: 65 HQEVNGSKLVYL---DSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELA 121 H V+G ++ D + P V + + + + ++A + E Sbjct: 41 HMTVDGRNMIGFASNDYLGLAAHPLLVAAITEGARRYGAGSGGSHLLGGHSRAHAQLE-- 98 Query: 122 RKKVARFINA--SDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPW 179 +A F + R + F+ + + + G + H S I Sbjct: 99 -DDLAEFAGGFVDNPRALYFSTGY-----MANLATLTALAGRGTTLFSDSLNHASLID-- 150 Query: 180 QIVSQKTGAVLKFVTLNEDEVPDINKLRELI---SPKTKLVAVHHVSNVLASSLPIEEIV 236 GA L + D L ++ KL+ V ++ P+ ++ Sbjct: 151 -------GARLSRADIQIYPHADAEALGAMLEASDAAVKLIVSDTVFSMDGDIAPLARLL 203 Query: 237 VWAHDVGAKVLVDACQSVPHM 257 A GA ++VD + Sbjct: 204 ELAEHHGAWLVVDDAHGFGVL 224 >6JRL-A nrPDB Length = 510 Score = 35.9 bits (81), Expect = 0.034, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 36/100 (36%), Gaps = 14/100 (14%) Query: 190 LKFVTLNEDEVPDINKLRELISPKTK-----LVAVHHVSNVLASS--LPIEEIVVWAHDV 242 ++ + ED V + LR I ++ V + + IE + + Sbjct: 206 IRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATL-GTTGTCAYDDIESLSAVCEEF 264 Query: 243 GAKVLVDACQSVPHMVV----DVQK-LN-ADFLVASSHKM 276 + VDA + + D++K L+ D L + HK Sbjct: 265 KVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKF 304 >6EEI-A nrPDB Length = 490 Score = 35.9 bits (81), Expect = 0.039, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 64/193 (33%), Gaps = 26/193 (13%) Query: 111 SAKATDEFELARKKVARFIN------ASDSREIVFTRNATEAINLVAYSWGLSNLKP--- 161 S AT+ + VA+ +N + + V +A+EA+ +V + L+ Sbjct: 119 SPAATELEMIVLDWVAKLLNLPEQFMSKGNGGGVIQGSASEAVLVVLIAARDKVLRSVGK 178 Query: 162 ---GDEVILTVAEHHSCIVPWQIVS--QKTGAVLKFVTLNEDEVPDINKLRELISPKT-- 214 V+ + + HS + ++ + + + L+E +S Sbjct: 179 NALEKLVVYSSDQTHSALQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEA 238 Query: 215 ----KLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQS-----VPHMVVDVQKLN 265 + + + + P+ + A+ G VDA + P + + Sbjct: 239 GLIPFFLCANVGTTSSTAVDPLAALGKIANSNGIWFHVDAAYAGSACICPEYRQYIDGVE 298 Query: 266 -ADFLVASSHKMC 277 AD ++HK Sbjct: 299 TADSFNMNAHKWF 311 >4FL0-A nrPDB Length = 456 Score = 35.9 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 57/418 (13%), Positives = 120/418 (28%), Gaps = 46/418 (11%) Query: 61 FRILHQE----VNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATD 116 F +++ + V L S T + + + ++ + + Y Sbjct: 53 FPEINRRELEHIEKHPNVQLISLGTGDTTEPIPEQITSHMSNFAHGLSTVEGYRGYGLEQ 112 Query: 117 EFELARKKVARFINA---SDSREIVFTRNATEAIN-LVAYSWGLSNLKPGDEVILTVAEH 172 + RK +A S E+ + A I+ L + D + Sbjct: 113 GNKTLRKAIAETFYRDLHVKSNEVFVSDGAQSDISRLQLLLGSNVTIAVQDPTFPAYIDS 172 Query: 173 HSCIVPWQIVSQKTG--AVLKFVTLNEDEV--PDINKLRELISPKTKLVAVHHVSNVLAS 228 I +KT + ++ + PD+ ++P+T ++ +N Sbjct: 173 SVIIGQTGHFHEKTKKYQNVVYMPCGPNNSFFPDL-----AMTPRTDVIFFCSPNNPTGY 227 Query: 229 S---LPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFL 285 + ++V +A G+ ++ D+ + D S +++ G + Sbjct: 228 VASRKQLHQLVDFAKTNGSIIIFDSAYAA---------FIEDGSPRSIYEIPGAREVAIE 278 Query: 286 YGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEA--IALGAAVDYLS 343 G +I D L + + T + A IA + LS Sbjct: 279 VSSFSKFAGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGASNIAQAGGLACLS 338 Query: 344 GIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVEGLHPTDLATF 403 G+ +I + Y E L D + + +G D+ Sbjct: 339 SGGLKEI----RSVNNYYKENRKILMDTLVSLGLKVYGGVNAPYLWVHFKGSKSWDVFNE 394 Query: 404 LDQQHGVAIRSGHHCAQPLHRYLGVNASARASLYFYNTKDDVDAFIVALADTVSFFNS 461 + + + G YL ++ R D + A +FFN+ Sbjct: 395 ILENTHIITVPGSGFGPGGEEYLRISGFGRR-----------DHIVEASKRLQNFFNT 441 >3NTJ-A nrPDB Length = 422 Score = 35.9 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 85/271 (31%), Gaps = 50/271 (18%) Query: 202 DINKLRELI-SPKTKLVAVHHVSNVLASSLPIEE----IVVWAHDVGAKVLVDACQSVPH 256 D+ L + + P V V +P + + + D Q+ Sbjct: 181 DLEALEKELQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQT--- 237 Query: 257 MVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYA 316 L + +H G L GK+ L GG L + Sbjct: 238 ------GLGRTGKLLCTHH-YGVKPDVILLGKA---------LSGGHYPISAILANDDVM 281 Query: 317 EPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGK-YLYEKLSSLPDVRIYG 375 E G+ G +A V+ L + K+ E ++G +L L D ++ Sbjct: 282 LVLKPGEHGSTYGGNPLAAAICVEALKVLINEKLCENADKLGAPFLQNLKEQLKDSKVV- 340 Query: 376 PRPSESVHRGALCSFNVEGLHPTDLATFLD-----QQHGVAIRSGHHCAQPLHRYLGVNA 430 E +G LC+ + DL D +++G+ RS H + Sbjct: 341 ---REVRGKGLLCAIEFK----NDLVNVWDICLKFKENGLITRSVH------------DK 381 Query: 431 SARASLYFYNTKDDVDAFIVALADTVSFFNS 461 + R + TK+ +D + TV FF+ Sbjct: 382 TVRLTPPLCITKEQLDECTEIIVKTVKFFDD 412 >3HQT-A nrPDB Length = 409 Score = 35.5 bits (80), Expect = 0.049, Method: Composition-based stats. Identities = 28/173 (16%), Positives = 54/173 (31%), Gaps = 31/173 (17%) Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP-HMVVDVQKL-------NAD 267 ++ V + + L + P+ E+V + + G +LVD S+ H L Sbjct: 189 IIVVDSIYSTLGTIAPLAELVNISKEFGCALLVDESHSLGTHGPNGAGLLAELGLTREVH 248 Query: 268 FLVASSHKMCGPTGIGFLYGKSDLLHSMP-------------PFLGGG-----EMISDVF 309 F+ AS K G ++ +++ +P P+ G E+I Sbjct: 249 FMTASLAKTFAYRA-GAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTLEIIESAD 307 Query: 310 LDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLY 362 + G +G I + + L ++ YL Sbjct: 308 NRRQHLDRMARKLRIGLSQLGLTIRSESQIIGLETGDERNTE----KVRDYLE 356 >6F35-A nrPDB Length = 410 Score = 35.1 bits (79), Expect = 0.059, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 51/144 (35%), Gaps = 12/144 (8%) Query: 85 PAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFIN-ASDSREIVFTRNA 143 P V A + + + + R+K R A + EI A Sbjct: 56 PEHVKQAASDAIHRG-----ETKYTALDGTPELKKAIREKFQRENGLAYELDEITVATGA 110 Query: 144 TEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDI 203 + + ++ +++L PGDEVI+ + + + + ++ + Sbjct: 111 KQ----ILFNAMMASLDPGDEVIIPTP-YWTSYSDIVHICEGKPVLIA-CDASSGFRLTA 164 Query: 204 NKLRELISPKTKLVAVHHVSNVLA 227 KL I+P+T+ V ++ SN Sbjct: 165 EKLEAAITPRTRWVLLNSPSNPSG 188 >3CIA-A nrPDB Length = 605 Score = 34.7 bits (78), Expect = 0.080, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 44/147 (29%), Gaps = 37/147 (25%) Query: 192 FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIE------------------ 233 ++ + + + I+ L+AV +N + + Sbjct: 153 WIPIQDTPSVRVT-YTARITTDKDLLAVMSANNEPGTERDGDYFFSMPQAIPPYLIAIGV 211 Query: 234 ---EIVVWAHDVGAK---VLVDACQSVPHMVVDVQKLNADFLVASSHKMCGPTGIGFLYG 287 E +H G ++DA + D + D + +M G + +G Sbjct: 212 GDLEFKAMSHQTGIYAESYILDAAVA----EFDDTQAMID----KAEQMYG----KYRWG 259 Query: 288 KSDLLHSMPPFLGGGEMISDVFLDHST 314 + DLL P F GG + T Sbjct: 260 RYDLLMLPPSFPFGGMENPRLSFITPT 286 >6CJB-A nrPDB Length = 391 Score = 34.7 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 30/75 (40%), Gaps = 5/75 (6%) Query: 204 NKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP--HMVVDV 261 + I+PKTKL+ + SN + + +I A + D + P + Sbjct: 137 ENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKYNLITVADNTFATPWIQRPL-- 194 Query: 262 QKLNADFLVASSHKM 276 +L D ++ S+ K Sbjct: 195 -ELGFDIVLHSATKY 208 >1N8P-A nrPDB Length = 393 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 70/199 (35%), Gaps = 27/199 (13%) Query: 87 AVLD--ALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRN-A 143 +V++ +L ++ + G + S E + VA NA + F+ A Sbjct: 24 SVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQ--YGLAFSSGSA 81 Query: 144 TEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDI 203 T A L + G + GD + H V+ G F + Sbjct: 82 TTATILQSLPQGSHAVSIGD---VYGGTHRYF----TKVANAHGVETSFT------NDLL 128 Query: 204 NKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGA----KVLVDACQSVPHM-- 257 N L +LI TKLV + +N I+++ A ++VD P++ Sbjct: 129 NDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISN 188 Query: 258 VVDVQKLNADFLVASSHKM 276 ++ AD +V S+ K Sbjct: 189 PLNF---GADIVVHSATKY 204 >3RUY-A nrPDB Length = 392 Score = 32.8 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 60/179 (33%), Gaps = 29/179 (16%) Query: 202 DINKLRELISPKTKLVAVHHVSNVLASSLP----IEEIVVWAHDVGAKVLVDACQSVPHM 257 D+ L+ I+P T + + ++P ++E + + D Q+ Sbjct: 171 DLEALKAAITPNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGR 230 Query: 258 VVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAE 317 V D+ + M + GK+ LGGG + Sbjct: 231 TGKV--FACDWDNVTP-DMY-------ILGKA---------LGGGVFPISCAAANRDILG 271 Query: 318 PPSRFEAGTPAI---GEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRI 373 FE G+ G +A ++ L + K+ E +++G+ L +L + + I Sbjct: 272 V---FEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLVGQLKEIDNPMI 327 >2OKJ-A nrPDB Length = 504 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 43/262 (16%), Positives = 75/262 (28%), Gaps = 35/262 (13%) Query: 131 ASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVL 190 A+ + ++FT E + G + D VIL I+P ++ A Sbjct: 185 AAVPKLVLFTS---EQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQ 241 Query: 191 K-FVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVD 249 K +V V + V + PI+EI + VD Sbjct: 242 KGYVP--------------------FYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVD 281 Query: 250 ACQSVP-----HMVVDVQKLN-ADFLVASSHKMCGP--TGIGFLYGKSDLLHSMPPFLGG 301 A + + A+ + + HKM G L + +L G Sbjct: 282 AAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAG 341 Query: 302 GEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYL 361 D D S Y + G + +G +E+ +YL Sbjct: 342 YLFQPDKQYDVS-YDTGDKAIQCGRH--VDIFKFWLMWKAKGTVGFENQINKCLELAEYL 398 Query: 362 YEKLSSLPDVRIYGPRPSESVH 383 Y K+ + + + E + Sbjct: 399 YAKIKNREEFEMVFNGEPEHTN 420 >3JTX-A nrPDB Length = 396 Score = 32.4 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 24/56 (42%), Gaps = 3/56 (5%) Query: 201 PDINKLRELISPKTKLVAVHHVSNVLASSLPIE---EIVVWAHDVGAKVLVDACQS 253 PD + E + +TKLV V +N S L ++ E+ G + D C S Sbjct: 156 PDWRSISEEVWKRTKLVFVCSPNNPSGSVLDLDGWKEVFDLQDKYGFIIASDECYS 211 >5M99-B nrPDB Length = 505 Score = 32.0 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 42/135 (31%), Gaps = 10/135 (7%) Query: 99 YNSNVHRGIHYLSAKATDEFELAR-----KKVARFINASDSREI-----VFTRNATEAIN 148 + + + Y TD + + + + + I I + + ++ Sbjct: 45 WFMPFNEAVSYHGYDITDYYNVEKDYGTMEDLENMIQVLHENGIKVIMDLVINHTSDEHP 104 Query: 149 LVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRE 208 + + P + + E HS W G + + L +PD+N + Sbjct: 105 WFKDAVENTTSSPYWDYYIMSLEDHSGQDHWHWKINSKGQKVWYFGLFGYNMPDLNHDSQ 164 Query: 209 LISPKTKLVAVHHVS 223 + + K + +S Sbjct: 165 KVREEVKKIVDFWIS 179 >1FC4-A nrPDB Length = 401 Score = 31.7 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 32/227 (14%), Positives = 69/227 (30%), Gaps = 34/227 (14%) Query: 86 AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATE 145 ++ A + + + + + D + +K+A F+ + + + + Sbjct: 62 PDLIAAAKAGMDSHGFGMASVRFICGTQ--DSHKELEQKLAAFLG---MEDAILYSSCFD 116 Query: 146 AINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINK 205 A + L D +I H S I G L D+ + Sbjct: 117 ANG----GLFETLLGAEDAIISDALNHASIID---------GVRLCKAKRYRYANNDMQE 163 Query: 206 LRELISP------KTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVP---- 255 L + + L+A V ++ ++ + A A V+VD +V Sbjct: 164 LEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGE 223 Query: 256 -----HMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSMPP 297 H DV D + + K G G+ + +++ + Sbjct: 224 NGRGSHEYCDVMG-RVDIITGTLGKALGGASGGYTAARKEVVEWLRQ 269 >2OKK-A nrPDB Length = 497 Score = 31.7 bits (70), Expect = 0.65, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 35/120 (29%), Gaps = 9/120 (7%) Query: 216 LVAVHHVSNVLASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLN------ADFL 269 LV+ + V + P+ + + VDA ++ K A+ + Sbjct: 244 LVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSV 303 Query: 270 VASSHKMCGPTGI--GFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTP 327 + HKM G L + L+ + D D S Y + G Sbjct: 304 TWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLS-YDTGDKALQCGRH 362 >2O1B-A nrPDB Length = 404 Score = 31.7 bits (70), Expect = 0.76, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 46/122 (37%), Gaps = 15/122 (12%) Query: 193 VTLN---EDEVPDINKLRELISPKTKLVAVHHVSNVLA---SSLPIEEIVVWAHDVGAKV 246 V LN +PD +K+ I KTKL+ + + +N + +E + K+ Sbjct: 158 VPLNLEPPHYLPDWSKVDSQIIDKTKLIYLTYPNNPTGSTATKEVFDEAIAKFKGTDTKI 217 Query: 247 LVDACQSV-------PHMVVDVQKLNADFLVASSHKMCGPTG--IGFLYGKSDLLHSMPP 297 + D P ++ + + S K +G +GF G D++ ++ Sbjct: 218 VHDFAYGAFGFDAKNPSILASENGKDVAIEIYSLSKGYNMSGFRVGFAVGNKDMIQALKK 277 Query: 298 FL 299 + Sbjct: 278 YQ 279 >3LRP-A nrPDB Length = 181 Score = 31.7 bits (70), Expect = 0.79, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 24/50 (48%) Query: 90 DALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVF 139 D ++ + Y SN I + + + + AR+++ R IN + ++ + Sbjct: 72 DKIRPLWRHYYSNTDGLIFVVDSNDRERIDDAREELHRMINEEELKDAII 121 >1NW6-A nrPDB Length = 319 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 22/59 (37%), Gaps = 2/59 (3%) Query: 67 EVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKV 125 +NG+ L + +QKPAAV++ L S V A + R + Sbjct: 212 RLNGNSLERVGHP--TQKPAAVIERLVRALSHPGSTVLDFFAGSGVTARVAIQEGRNSI 268 >4EFI-A nrPDB Length = 354 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 47/146 (32%), Gaps = 12/146 (8%) Query: 73 LVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINAS 132 L++ D+ + + DA ++ + R + S A +++A Sbjct: 171 LLFGDAGTMTALETSNGDAAAHFIIGADGKGARNLIVPSGGFKPYDAAADERMA----GK 226 Query: 133 DSREIVFTRNATE---AINLVAY--SWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTG 187 E +F +N V S L + H + + + +++K G Sbjct: 227 SP-ECLFMDGGEIFNFTLNAVPKLVSRTLDIAGRDKDSYDAFLFHQANLFMLKHLAKKAG 285 Query: 188 AVLKFVTLN--EDEVPDINKLRELIS 211 + V +N E + LI+ Sbjct: 286 LPAERVPVNIGEYGNTSCASIPLLIT 311 >2X5F-A nrPDB Length = 430 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 45/113 (39%), Gaps = 13/113 (11%) Query: 138 VFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHH-SCIVPWQIVSQKTGAVLKFVTL- 195 + T T ++LV G + D ++L EH+ + + + GA L+ + Sbjct: 117 IVTNALTHGLSLV----GDLFVNQDDTILL--PEHNWGNYK--LVFNTRNGANLQTYPIF 168 Query: 196 NEDEVPDINKLRELI---SPKTKLVAVHHVSNVLASSLPIEEIVVWAHDVGAK 245 ++D + L E + + ++ +++ +N + +E+ + A Sbjct: 169 DKDGHYTTDSLVEALQSYNKDKVIMILNYPNNPTGYTPTHKEVTTIVEAIKAL 221 >4AK9-A nrPDB Length = 318 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 49/134 (36%), Gaps = 12/134 (8%) Query: 83 QKPAAVL-DALQNYYEFYNS----NVHRGIHYLSAKATDEFELAR--KKVARFINASDSR 135 +PAAVL A++ E + +H + E R K+ +S Sbjct: 182 PRPAAVLSQAVRRAVEEDFDVVLCDTSGRLHTN----YNLMEELRGCKRAVSKALSSAPN 237 Query: 136 EIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTL 195 E++ + T +N++A + + + ILT + + V + +KFV + Sbjct: 238 EVLLVLDGTTGLNMLAQAREFNQVIGVTGFILTKLDGTARGGCVVSVVDELSIPVKFVGV 297 Query: 196 NEDEVPDINKLREL 209 E + D+ Sbjct: 298 GE-GIDDLQPFDAQ 310 >3DM5-A nrPDB Length = 443 Score = 30.1 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 29/85 (34%), Gaps = 1/85 (1%) Query: 123 KKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILTVAEHHSCIVPWQIV 182 +++ + N E++ + T + P +I+T + + Sbjct: 202 EEMKQISNVIHPHEVILVIDGTIGQQAYNQALAFKEATPIGSIIVTKLDGSAKGGGALSA 261 Query: 183 SQKTGAVLKFVTLNEDEVPDINKLR 207 TGA +KF+ E + DI Sbjct: 262 VAATGAPIKFIGTGEK-IDDIEPFD 285 >4R2N-A nrPDB Length = 367 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 37/200 (18%), Positives = 72/200 (36%), Gaps = 23/200 (11%) Query: 53 LGHRVRKDFRILHQEVNGSKL---VYLDSAATSQKP-AAVLDALQNYYEFYNSNVHRGIH 108 + R+R + L V G + + L S T P +V A+ + N G Sbjct: 2 VTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCV 61 Query: 109 YLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVILT 168 L + +AR + + E V + ++ GDEV+ Sbjct: 62 QL-----------KAALARHLGPDFAPEHVAVGCGSVSL---CQQLVQVTASVGDEVVFG 107 Query: 169 VAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLAS 228 P V+ GA+ V L D D+ + ++ +T+L+ V + +N ++ Sbjct: 108 WRSFE-LYPPQVRVA---GAIPIQVPL-TDHTFDLYAMLATVTDRTRLIFVCNPNNPTST 162 Query: 229 SLPIEEIVVWAHDVGAKVLV 248 + + + + V A +L+ Sbjct: 163 VVGPDALARFVEAVPAHILI 182 >5L3P-c nrPDB Length = 233 Score = 29.7 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 17/41 (41%) Query: 255 PHMVVDVQKLNADFLVASSHKMCGPTGIGFLYGKSDLLHSM 295 + + + + D+ + +H G G+ K ++L M Sbjct: 171 GRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGM 211 >4KDR-A nrPDB Length = 223 Score = 29.7 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 39/110 (35%), Gaps = 5/110 (4%) Query: 283 GFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYL 342 G L+GK L GGG + + + +T FE A A+ G VDY+ Sbjct: 59 GGLFGKKVLDVGC----GGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYV 114 Query: 343 SGIGMPKIHEYEVEIGKYL-YEKLSSLPDVRIYGPRPSESVHRGALCSFN 391 ++ + E L +PD + ++ V G F+ Sbjct: 115 QETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFS 164 >4KDC-A nrPDB Length = 246 Score = 29.7 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 39/110 (35%), Gaps = 5/110 (4%) Query: 283 GFLYGKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYL 342 G L+GK L GGG + + + +T FE A A+ G VDY+ Sbjct: 59 GGLFGKKVLDVGC----GGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYV 114 Query: 343 SGIGMPKIHEYEVEIGKYL-YEKLSSLPDVRIYGPRPSESVHRGALCSFN 391 ++ + E L +PD + ++ V G F+ Sbjct: 115 QETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFS 164 >2C44-A nrPDB Length = 471 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 25/70 (35%), Gaps = 6/70 (8%) Query: 232 IEEIVVWAHDVGA-KVLVDACQSVPHMVVD---VQKLNADFLVASSHKMCGPTGIGFLYG 287 +EEI V G VDA + +PH+ D Q L + + + FL G Sbjct: 345 LEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAG--IRAVEIGSFLLG 402 Query: 288 KSDLLHSMPP 297 + P Sbjct: 403 RDPKTGKQLP 412 >5B5R-A nrPDB Length = 468 Score = 29.3 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 63/174 (36%), Gaps = 21/174 (12%) Query: 34 CSAAAASSATISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQ 93 CSA + + IS + E L + +DF+ L +EV Q+ ++ L Sbjct: 244 CSAFISPTQMISEEPEEEKLIGEMHEDFKTLKEEV--------------QRETQEVEKLS 289 Query: 94 NYYEFYNSNVHRGIHYLSAKATDE---FELARKKVARFINASDSREIVFTRNATEAINLV 150 + + D E A K + + ++++ +++A +AI Sbjct: 290 PVGRSSLLTSLSHLLGKKKELQDLEQKLEGALDKGQKVTLEALPKDVLLSKDAMDAILYF 349 Query: 151 AYSWGLSNLKPGDEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDIN 204 + + +++ E I+P Q+ ++ F+ +++ V + Sbjct: 350 LGALTELTEEQLK-ILVKSLEKK--ILPVQLKLVESTLEQNFLQ-DKEGVFPLQ 399 >5HX2-G nrPDB Length = 602 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 22/59 (37%), Gaps = 6/59 (10%) Query: 178 PWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHVSNVLASSLPIEEIV 236 W+ +E+ +P+I + ++ + +N L + L +EI+ Sbjct: 348 TWEQSHTDYSVE-----TDENGIPEILHFDSVF-EHGDIINITWFNNDLGTLLTKDEII 400 >4FHN-X nrPDB Length = 450 Score = 29.3 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 27/83 (32%), Gaps = 13/83 (15%) Query: 63 ILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELAR 122 ++ E G LVY +A+ + + + A E A Sbjct: 208 LIRPEATGYGLVYF------------TEAMLKRHGMGFEGMRVSVSGSGNVAQYAIEKAM 255 Query: 123 KKVARFINASD-SREIVFTRNAT 144 + AR I ASD S +V T Sbjct: 256 EFGARVITASDSSGTVVDESGFT 278 >6EEW-A nrPDB Length = 500 Score = 29.0 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 23/54 (42%), Gaps = 10/54 (18%) Query: 231 PIEEIVVWAHDVGAKVLVDACQS--------VPHMVVDVQKLNADFLVASSHKM 276 P++ + A++ G + VDA + H + +++ D L S HK Sbjct: 269 PVDSLSEIANEFGIWIHVDAAYAGSACICPEFRHYLDGIER--VDSLSLSPHKW 320 >2YFH-A nrPDB Length = 448 Score = 29.0 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 25/77 (32%), Gaps = 12/77 (15%) Query: 63 ILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELAR 122 ++ E G LVY +A+ + + + A E A Sbjct: 204 LIRPEATGYGLVYF------------TEAMLKRHGMGFEGMRVSVSGSGNVAQYAIEKAM 251 Query: 123 KKVARFINASDSREIVF 139 + AR I ASDS V Sbjct: 252 EFGARVITASDSSGTVV 268 >4TLV-A nrPDB Length = 591 Score = 28.2 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 25/66 (37%) Query: 80 ATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVARFINASDSREIVF 139 +TS+ P A + ++ Y R + +A F AR ++ R++VF Sbjct: 51 STSETPTAAIRFFGSWLREYVPEHPRRAYLYEIRADQHFYNARATGENLLDLMRQRQVVF 110 Query: 140 TRNATE 145 E Sbjct: 111 DSGDRE 116 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.126 0.310 Lambda K H 0.267 0.0390 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,355,435 Number of Sequences: 36641 Number of extensions: 550943 Number of successful extensions: 2184 Number of sequences better than 10.0: 175 Number of HSP's better than 10.0 without gapping: 132 Number of HSP's successfully gapped in prelim test: 102 Number of HSP's that attempted gapping in prelim test: 1913 Number of HSP's gapped (non-prelim): 241 length of query: 463 length of database: 10,336,785 effective HSP length: 100 effective length of query: 363 effective length of database: 6,672,685 effective search space: 2422184655 effective search space used: 2422184655 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)