BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q93VR3 (377 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2C54-A nrPDB 791 0.0 1GFS-A nrPDB 101 6e-22 6BWL-A nrPDB 84 1e-16 3RUE-A nrPDB 81 7e-16 1R66-A nrPDB 69 5e-12 2C20-A nrPDB 65 3e-11 3M2P-A nrPDB 65 5e-11 2Q1T-A nrPDB 64 9e-11 3SXP-A nrPDB 63 2e-10 2HUN-A nrPDB 62 3e-10 1OC2-A nrPDB 62 5e-10 4EJ0-A nrPDB 58 5e-09 3WMX-A nrPDB 54 1e-07 1UDA-A nrPDB 52 6e-07 3RFT-A nrPDB 51 7e-07 4WOK-A nrPDB 48 9e-06 1EQ2-A nrPDB 47 2e-05 6BI4-A nrPDB 46 3e-05 1KEU-A nrPDB 46 3e-05 2X86-A nrPDB 45 6e-05 1BXK-A nrPDB 43 2e-04 6AQY-A nrPDB 43 3e-04 4WKG-A nrPDB 42 3e-04 1ORR-A nrPDB 42 3e-04 2PK3-A nrPDB 39 0.005 1Z45-A nrPDB 39 0.005 4R1U-A nrPDB 37 0.011 4R1T-A nrPDB 36 0.025 4QUK-A nrPDB 34 0.13 1GY8-A nrPDB 33 0.18 4QQR-A nrPDB 32 0.35 2NNL-D nrPDB 32 0.35 3ENK-A nrPDB 32 0.39 5B6K-A nrPDB 32 0.40 4J2O-A nrPDB 32 0.41 1C8U-A nrPDB 32 0.44 4PVC-A nrPDB 32 0.52 1ZZE-A nrPDB 30 1.8 2F6R-A nrPDB 30 2.4 4KCA-A nrPDB 29 2.8 1RPN-A nrPDB 29 3.8 5VT6-A nrPDB 28 5.6 5UPR-A nrPDB 28 5.7 >2C54-A nrPDB Length = 379 Score = 791 bits (2044), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/377 (99%), Positives = 377/377 (100%) Query: 1 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK 60 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK Sbjct: 3 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK 62 Query: 61 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT 120 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT Sbjct: 63 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT 122 Query: 121 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLA 180 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLE+LA Sbjct: 123 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLERLA 182 Query: 181 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL 240 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL Sbjct: 183 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL 242 Query: 241 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 300 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP Sbjct: 243 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 302 Query: 301 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG 360 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG Sbjct: 303 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG 362 Query: 361 TQAPVQLGSLRAADGKE 377 TQAPVQLGSLRAADGKE Sbjct: 363 TQAPVQLGSLRAADGKE 379 >1GFS-A nrPDB Length = 321 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 81/330 (24%), Positives = 142/330 (43%), Gaps = 32/330 (9%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 ++ I G G + S I R+L+ G + + DE +L+D R + + Sbjct: 5 RVFIAGHRGMVGSAIRRQLEQRGDVELVLRTR-----------DELNLLDSRAVHDFF-A 52 Query: 89 TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYP 148 +E +D V+ AA +GG+ + + +Y N MI N+I AA N + + + S+CIYP Sbjct: 53 SERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKLLFLGSSCIYP 112 Query: 149 EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPF 208 + + L + P + Y + K+A +LC+ YN+ +G + R N+YGP Sbjct: 113 KLAKQPMAESELLQGTLEPT--NEPYAIAKIAGIKLCESYNRQYGRDYRSVMPTNLYGPH 170 Query: 209 GTWKGGREKAPAAFCRK-----AQTSTDRFEMWGDGLQTRSFTFIDECVEG---VLRLTK 260 + A R+ AQ + D +WG G R F +D+ V+ L Sbjct: 171 DNFHPSNSHVIPALLRRFHEATAQNAPD-VVVWGSGTPMREFLHVDDMAAASIHVMELAH 229 Query: 261 SDFRE-------PVNIGSDEMVSMNEMAEMVLSFE-EKKLPIHHIPGPEGVRGRNSDNNL 312 + E +N+G+ ++ E+A+ + K + P+G + D Sbjct: 230 EVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASKPDGTPRKLLDVTR 289 Query: 313 IKEKLGWAPNMRLKEGLRITYFWIKEQIEK 342 + +LGW + L+ GL TY W E ++ Sbjct: 290 L-HQLGWYHEISLEAGLASTYQWFLENQDR 318 >6BWL-A nrPDB Length = 328 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/321 (23%), Positives = 142/321 (44%), Gaps = 22/321 (6%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNE---HMTE---DMF---CDEFHLVD 78 +KI +TG GFI + +RL + H V D N ++TE D+ C + + D Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQCIQGDIKD 60 Query: 79 LRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRF 138 +++ + D ++LAA + I + N+T+ +FN++E +N + Sbjct: 61 KKLVAQLFE-NNSFDLCYHLAASINVQDSIDDARAT-FENDTIGTFNLLEQC-LNYDVKM 117 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRI 198 + S+ +Y + ++ + E D P +P Y K+A E + Y + + + Sbjct: 118 VFMSTCMVYDKATNIQ----GISELD--PIKPASPYAGSKIAAENMVLSYYYAYKLPVVV 171 Query: 199 GRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRL 258 R N YGPF K G E A + ++GDG QTR ++++C + V+ Sbjct: 172 IRPFNTYGPFQ--KTGGEGGVVAIFINNKLDNVPLNIYGDGKQTRDLLYVEDCADFVVAA 229 Query: 259 TKSDFRE--PVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEK 316 S +N G+ + +S+N++AE++ + + HI ++ + K Sbjct: 230 GYSAKANGHIINAGTGQDISINKLAELISGNKVSIQHVTHIHPQSEIQKLLCNYEKAKTI 289 Query: 317 LGWAPNMRLKEGLRITYFWIK 337 L W P + L++G+ T WIK Sbjct: 290 LNWEPKVSLEDGVIKTEEWIK 310 >3RUE-A nrPDB Length = 351 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 90/335 (26%), Positives = 150/335 (44%), Gaps = 51/335 (15%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIASDWKKNEHM-----------TE--DMFCDEFHLVD 78 ITG GFI S++ +L VI D H TE FC F D Sbjct: 30 ITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWSRFC--FIEGD 87 Query: 79 LRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS--FNMIEAARINGIK 136 +R + C +V +GVDHV + AA +G + +S I N T I+ N++ AA+ ++ Sbjct: 88 IRDLTTCEQVMKGVDHVLHQAA-LGSVP--RSIVDPITTNATNITGFLNILHAAKNAQVQ 144 Query: 137 RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 F YA+S+ Y + L ++E+ P P Y + K E + Y + +G + Sbjct: 145 SFTYAASSSTYGDHPALP----KVEENIGNPLSP---YAVTKYVNEIYAQVYARTYGFKT 197 Query: 197 RIGRFHNIYG----PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECV 252 R+ N++G P G + K AA + D + GDG +R F +ID + Sbjct: 198 IGLRYFNVFGRRQDPNGAYAAVIPKWTAAMLKG-----DDVYINGDGETSRDFCYIDNVI 252 Query: 253 E-GVLR-LTKSDFREPV-NIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPE-------- 301 + +L L K ++ + N+ + ++NE++ + ++E L IHHI Sbjct: 253 QMNILSALAKDSAKDNIYNVAVGDRTTLNELSGYI--YDELNL-IHHIDKLSIKYREFRS 309 Query: 302 -GVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFW 335 VR +D + L + PN++++EGLR++ W Sbjct: 310 GDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPW 344 >1R66-A nrPDB Length = 337 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 74/327 (22%), Positives = 130/327 (39%), Gaps = 28/327 (8%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASD---------WKKNEHMTEDMFCD---EFH 75 +++ +TG GFI SH R+L + + +D + N + D F Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRLRFV 60 Query: 76 LVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGI 135 D+R + GVD + + AA+ I + SV N + +++ A G+ Sbjct: 61 HGDIRDAGLLARELRGVDAIVHFAAESHVDRSI-AGASVFTETNVQGTQTLLQCAVDAGV 119 Query: 136 KRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIE 195 R + S+ +Y T S P EP Y K ++ + + Y++ +G++ Sbjct: 120 GRVVHVSTDEVYGSIDSGSWTESS-------PLEPNSPYAASKAGSDLVARAYHRTYGLD 172 Query: 196 CRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV 255 RI R N YGP+ + + P T ++GDG R + D+ G+ Sbjct: 173 VRITRCCNNYGPY---QHPEKLIPLFVTNLLDGGT--LPLYGDGANVREWVHTDDHCRGI 227 Query: 256 -LRLTKSDFREPVNIGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNS-DNNL 312 L L E +IG ++ E+ ++L S + + +G R S D Sbjct: 228 ALVLAGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSSVRKVADRKGHDLRYSLDGGK 287 Query: 313 IKEKLGWAPNMRLKEGLRITYFWIKEQ 339 I+ +LG+ P + +GL T W +E Sbjct: 288 IERELGYRPQVSFADGLARTVRWYREN 314 >2C20-A nrPDB Length = 330 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 78/332 (23%), Positives = 138/332 (41%), Gaps = 33/332 (9%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCD--EFHLVDLRVMENCLK 87 I I G G+I SH ++L EG V+ D + H ED + +F+ DLR Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGH--EDAITEGAKFYNGDLRDKAFLRD 61 Query: 88 V--TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMI-SFNMIEAARINGIKRFFYASSA 144 V E ++ V + AAD + + + YNN + + ++E + +F ++S+A Sbjct: 62 VFTQENIEAVMHFAAD--SLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTA 119 Query: 145 CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNI 204 Y E +V L + P + YG KLA E++ Y++ + +I R+ N+ Sbjct: 120 ATYGE------VDVDLITEETM-TNPTNTYGETKLAIEKMLHWYSQASNLRYKIFRYFNV 172 Query: 205 YGPFGTWKGGREKAPAA-----FCRKAQTSTDRFEMWGDGLQT------RSFTFIDECVE 253 G G + P + A ++ M+GD T R + +++ V Sbjct: 173 AGATPNGIIGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVA 232 Query: 254 ----GVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR-NS 308 G+ L + N+G+ S+ E+ + V ++P P G R + Sbjct: 233 AHFLGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVA 292 Query: 309 DNNLIKEKLGWAPN-MRLKEGLRITYFWIKEQ 339 + KEKLGW P + +K + + W ++Q Sbjct: 293 SSQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQ 324 >3M2P-A nrPDB Length = 311 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 131/298 (43%), Gaps = 24/298 (8%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 LKI++TG GF+ ++ +K++G+ I D E+ + D +E+ + Sbjct: 3 LKIAVTGGTGFLGQYVVESIKNDGNTPIILTRSIGNKAINDY---EYRVSDY-TLEDLIN 58 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 VD V +LAA G G I H +N +++ N+ +A N I YAS+ Y Sbjct: 59 QLNDVDAVVHLAATRGSQGKISEFH-----DNEILTQNLYDACYENNISNIVYASTISAY 113 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 + ET SL ++ P YG+ KLA E + Y++ G+ + RF ++YG Sbjct: 114 SD----ET---SLPWNEKELPLPDLMYGVSKLACEHIGNIYSRKKGLCIKNLRFAHLYG- 165 Query: 208 FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVL-RLTKSDFREP 266 + F R+A ++ + + + R F + + + V+ L + Sbjct: 166 ---FNEKNNYMINRFFRQA-FHGEQLTLHANSVAKREFLYAKDAAKSVIYALKQEKVSGT 221 Query: 267 VNIGSDEMVSMNEMAEMV-LSFEEK-KLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPN 322 NIGS + ++ E+A + +F K L + + EG+ D++ KE L ++ + Sbjct: 222 FNIGSGDALTNYEVANTINNAFGNKDNLLVKNPNANEGIHSSYMDSSKAKELLDFSTD 279 >2Q1T-A nrPDB Length = 377 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 77/341 (22%), Positives = 142/341 (41%), Gaps = 41/341 (12%) Query: 27 NLKISITGAGGFIASHIARRLKHEG----HYV--IASDWKKNEHMTEDMFCDEFHLVDLR 80 N + + G GF+ S++ +RL G H V + S K N + E + D Sbjct: 32 NTNVMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSAEKINVPDHPAVRFSETSITDDA 91 Query: 81 VMENCLKVTEGVDHVFNLAADMGGMGFIQ---SNHSVIMYNNTMISFNMIEAAR-INGIK 136 ++ + + + D+VF+LA G I ++H NNT+ + + E + +K Sbjct: 92 LLAS---LQDEYDYVFHLATYHGNQSSIHDPLADHE----NNTLTTLKLYERLKHFKRLK 144 Query: 137 RFFYASSAC-----IYPEFKQLETTN-VSLKESDAWPAEPQDAYGLEKLATEELCKHYNK 190 + Y+++ C + + K E T+ VSL +D+ Y + K+ E +Y+K Sbjct: 145 KVVYSAAGCSIAEKTFDDAKATEETDIVSLHNNDS-------PYSMSKIFGEFYSVYYHK 197 Query: 191 DFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFE--------MWGDGLQT 242 + RF N+YGP GR + A + T T ++ + G+ T Sbjct: 198 QHQLPTVRARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPLENGGVAT 257 Query: 243 RSFTFIDECVEGVLRLTKSDFREPV-NIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPG-P 300 R F F+++ G++ V NI S + S+ ++A + + +P P Sbjct: 258 RDFIFVEDVANGLIACAADGTPGGVYNIASGKETSIADLATKINEITGNNTELDRLPKRP 317 Query: 301 EGVRG-RNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQI 340 G R + +LG++ ++ + +GLR T W K + Sbjct: 318 WDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEWTKANL 358 >3SXP-A nrPDB Length = 362 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 87/370 (23%), Positives = 151/370 (40%), Gaps = 57/370 (15%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGH----YVIASDWKKNEHMT--------------- 66 EN I ITG GF+ S++A + E H V+ ++ N + Sbjct: 9 ENQTILITGGAGFVGSNLAFHFQ-ENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIG 67 Query: 67 ---EDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS 123 E + D + +DLR +E D++F+ AA N ++M N Sbjct: 68 FKGEVIAADINNPLDLRRLEKL-----HFDYLFHQAAVSDTTML---NQELVMKTNYQAF 119 Query: 124 FNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEE 183 N++E AR K YASSA +Y K NV K P++ YG KL +E Sbjct: 120 LNLLEIARSKKAK-VIYASSAGVYGNTK---APNVVGKNE-----SPENVYGFSKLCMDE 170 Query: 184 LCKHYNKDFGIECRIG-RFHNIYGPFGTWKGGREKAPAAFCRKA--QTSTDRFEMWGDGL 240 ++ D ++G R+ N+YGP +K EK + + A + +++ G Sbjct: 171 FVLSHSND---NVQVGLRYFNVYGPREFYK---EKTASMVLQLALGAMAFKEVKLFEFGE 224 Query: 241 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 300 Q R F +I++ ++ ++ K+ N+G + S NE+ +L + +I P Sbjct: 225 QLRDFVYIEDVIQANVKAMKAQKSGVYNVGYSQARSYNEIVS-ILKEHLGDFKVTYIKNP 283 Query: 301 EGVRGRNSDNNL--IKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKV 358 +++ ++ L + P L+ G++ I + ++AKG +SK+ Sbjct: 284 YAFFQKHTQAHIEPTILDLDYTPLYDLESGIKDYLPHIHAIFKGQRAKGE-----LNSKL 338 Query: 359 VGTQAPVQLG 368 G P LG Sbjct: 339 EGKPIPNLLG 348 >2HUN-A nrPDB Length = 336 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 78/323 (24%), Positives = 141/323 (43%), Gaps = 29/323 (8%) Query: 27 NLKISITGAGGFIASHIARRL--KHEGHYVIASD---WKKNEHMTEDMFCDE---FHLVD 78 ++K+ +TG GFI S+ R + KH VI D + N +D+ D F D Sbjct: 3 SMKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDDPRYTFVKGD 62 Query: 79 LRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARI-NGIKR 137 + E ++ VD V +LAA+ I S+ + +++N + ++ ++E+ R N R Sbjct: 63 VADYELVKELVRKVDGVVHLAAESHVDRSI-SSPEIFLHSNVIGTYTLLESIRRENPEVR 121 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECR 197 F + S+ +Y + + S E+D P Y K A++ L + + + + Sbjct: 122 FVHVSTDEVYGDILK-----GSFTENDR--LMPSSPYSATKAASDMLVLGWTRTYNLNAS 174 Query: 198 IGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV-L 256 I R N YGP+ + + P R + + ++G G R + ++++ V + L Sbjct: 175 ITRCTNNYGPY---QFPEKLIPKTIIRASLGL--KIPIYGTGKNVRDWLYVEDHVRAIEL 229 Query: 257 RLTKSDFREPVNIGSDEMVSMNEMAEMVLSF----EEKKLPIHHIPGPEGVRGRNSDNNL 312 L K + RE NI + E + E+ +++L EE + PG + + D+ Sbjct: 230 VLLKGESREIYNISAGEEKTNLEVVKIILRLMGKGEELIELVEDRPGHD--LRYSLDSWK 287 Query: 313 IKEKLGWAPNMRLKEGLRITYFW 335 I L W P EG++ T W Sbjct: 288 ITRDLKWRPKYTFDEGIKKTIDW 310 >1OC2-A nrPDB Length = 348 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 85/354 (24%), Positives = 145/354 (40%), Gaps = 47/354 (13%) Query: 30 ISITGAGGFIASHIARRL--KHEGHYVIASD---WKKNEHMTEDMFCDEFHLV--DLRVM 82 I +TG GFI S+ + H +V D + N+ E + D LV D+ Sbjct: 7 IIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVELVVGDIADA 66 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 E K+ D + + AA+ + ++ S ++ N + ++ ++EAAR I RF + S Sbjct: 67 ELVDKLAAKADAIVHYAAESHNDNSL-NDPSPFIHTNFIGTYTLLEAARKYDI-RFHHVS 124 Query: 143 SACIYPEFKQLETTNVSLKESDAWPAE---------PQDAYGLEKLATEELCKHYNKDFG 193 + +Y + E L P E P Y K A++ + K + + FG Sbjct: 125 TDEVYGDLPLRE----DLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIVKAWVRSFG 180 Query: 194 IECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTST---DRFEMWGDGLQTRSFTFIDE 250 ++ I N YGP+ + F + T+ + +++G+G R + ++ Sbjct: 181 VKATISNCSNNYGPY--------QHIEKFIPRQITNILAGIKPKLYGEGKNVRDWIHTND 232 Query: 251 CVEGVLR-LTKSDFREPVNIGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNS 308 GV LTK E IG+D + E+ E++L + K H+ G R + Sbjct: 233 HSTGVWAILTKGRMGETYLIGADGEKNNKEVLELILEKMGQPKDAYDHVTDRAGHDLRYA 292 Query: 309 -DNNLIKEKLGWAPNMR-LKEGLRITYFWI----------KEQIEKEKAKGSDV 350 D + ++++LGW P EGL T W KE +E AK +V Sbjct: 293 IDASKLRDELGWTPQFTDFSEGLEETIQWYTDNQDWWKAEKEAVEANYAKTQEV 346 >4EJ0-A nrPDB Length = 342 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 87/359 (24%), Positives = 153/359 (42%), Gaps = 75/359 (20%) Query: 28 LKISITGAGGFIASHIARRLKHEGHY-VIASDWKKNEHMTEDMFCDEF-HLVDLRVMENC 85 + + +TGA GFI +++ + L G +IA D ++T D+F +LVD + ++ Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVD-----NLTR---ADKFKNLVDCEI-DDY 63 Query: 86 LKVTEGVDH-----------VFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARING 134 L TE V+ VF+ A M +++ +M NN S +++A G Sbjct: 64 LDKTEFVERFARGDFGKVRAVFHEGACSDTM---ETDGRYMMDNNFRYSRAVLDACLAQG 120 Query: 135 IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI 194 + F YASSA IY + V +E +A P + YG K +++ + G Sbjct: 121 AQ-FLYASSAAIYGGSSRF----VEEREVEA----PLNVYGYSKFLFDQVIRRVMP--GA 169 Query: 195 ECRIG--RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTD-------RFEMWGDGLQTRSF 245 + +I R+ N+YGP + KG A AF Q + + +G G QTR F Sbjct: 170 KSQIAGFRYFNVYGPRESHKG--RMASVAFHNFNQFRAEGKVKLFGEYSGYGPGEQTRDF 227 Query: 246 TFIDECVEGVLRLTKSDFREP-----VNIGSDEMVSMNEMAEMV--------------LS 286 VE V ++ F P N+G+ N++A V L+ Sbjct: 228 V----SVEDVAKVNLYFFDHPEKSGIFNLGTGRAQPFNDIAATVVNTLRALEGQPALTLA 283 Query: 287 FEEKKLPIHHIPGPEGVRGR-----NSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQI 340 + ++ + ++P P+ +RG+ +D ++ AP + ++EG+ W+ Q+ Sbjct: 284 EQVEQGLVEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDRYVRWLFGQL 342 >3WMX-A nrPDB Length = 358 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 26/185 (14%) Query: 29 KISITGAGGFIASHIARRL--KHEGHYVIASD---WKKNEHMTEDMF--CDEFHLVDLRV 81 KI I GA G I S +A L ++ VI SD ++ H+T +M D L V Sbjct: 27 KILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHVHLTHEMLNATDRGELAT--V 84 Query: 82 MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISF-NMIEAARINGIKRFFY 140 +E G+ V+ LAA + G + +N M S N++E AR G++R F+ Sbjct: 85 VER-----HGITQVYLLAAALSATGEKAPQWA---WNLNMTSLLNVLELARQTGLERVFW 136 Query: 141 ASS-ACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 SS A P +T ++ E P YG+ K A E C+ Y+ + G++ R Sbjct: 137 PSSIAAFGPTTPAGQTPQKTVME-------PTTVYGISKQAGEGWCRWYHANHGVDVRSV 189 Query: 200 RFHNI 204 R+ + Sbjct: 190 RYPGL 194 >1UDA-A nrPDB Length = 338 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 76/337 (22%), Positives = 132/337 (39%), Gaps = 38/337 (11%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH-----MTEDMFCDEFHLVDLRVM 82 +++ +TG G+I SH +L GH VI D N + E + V+ + Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFI-QSNHSVIMY--NNTMISFNMIEAARINGIKRFF 139 L DH + G+ + +S + Y NN + +I A R +K F Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWP-AEPQDAYGLEKLATEELCKHYNK---DFGIE 195 ++SSA +Y + N + +++P PQ YG KL E++ K D+ I Sbjct: 121 FSSSATVYGD-------NPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 Query: 196 CRIGRFHNIYG--PFGTWKGGREKAP----AAFCRKAQTSTDRFEMWG------DGLQTR 243 + R+ N G P G + P + A D ++G DG R Sbjct: 174 --LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVR 231 Query: 244 SFTFIDECVEG-VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEE---KKLPIHHIPG 299 + + + +G V+ + K + V+I + N + ++V +F + K + H P Sbjct: 232 DYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPR 291 Query: 300 PEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFW 335 EG + +D + +L W L E + T+ W Sbjct: 292 REGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 >3RFT-A nrPDB Length = 267 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 70/173 (40%), Gaps = 14/173 (8%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 ++ +TGA G + + RL + +D + + C + L D + + Sbjct: 5 RLLVTGAAGQLGRVMRERLAPMAEILRLADLSPLDPAGPNEECVQCDLADANAVNAMVAG 64 Query: 89 TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYP 148 +G+ H +GG+ ++ I+ N + +N+ EAAR +G R +ASS Sbjct: 65 CDGIVH-------LGGIS-VEKPFEQILQGNIIGLYNLYEAARAHGQPRIVFASSNHTIG 116 Query: 149 EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 + Q E + PA P YG+ K E L + Y FG E + R Sbjct: 117 YYPQTERLGPDV------PARPDGLYGVSKCFGENLARMYFDKFGQETALVRI 163 >4WOK-A nrPDB Length = 336 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 69/321 (21%), Positives = 120/321 (37%), Gaps = 53/321 (16%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMT--------EDMFCDEFHLVDLRV 81 + + G GFI SH A+ L +G+ + D H + E D+ LV+ Sbjct: 14 VLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRWGDFVEGDILDQARLVE--T 71 Query: 82 MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYA 141 ME V V + AA +G + + NN + ++++A R+ + ++ Sbjct: 72 MEKYAPVA-----VIHFAAS-AYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQNVIFS 125 Query: 142 SSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 SS Y +L + E +A P + YG KL E + Y +G+ R+ Sbjct: 126 SSCATYGVPSRL-----PIGEGEAQ--NPINPYGRTKLIAEHMLADYAVAYGLRYVALRY 178 Query: 202 HNIYGPFGTWKGGREKAPAAFC-----RKAQTSTDRFEMWGDGLQTRSFTFIDECVE--- 253 N G + G + P A D E++GD +T T I + + Sbjct: 179 FNASGADIDGELGEKHDPETHLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYIHVTD 238 Query: 254 -------GVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR 306 V L ++ VN+G+ S+ E+ + + + +P+ +R R Sbjct: 239 LARAHVLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPV-------AMRAR 291 Query: 307 N--------SDNNLIKEKLGW 319 +D L EKLG+ Sbjct: 292 RAGDPPALYADPALAAEKLGF 312 >1EQ2-A nrPDB Length = 310 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 115/292 (39%), Gaps = 37/292 (12%) Query: 30 ISITGAGGFIASHIARRLKHEG--HYVIASDWKKNEHMTEDMFCDEFHLVDLRVMEN--- 84 I +TG GFI S+I + L +G ++ + K +LVDL + + Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFV--------NLVDLNIADYMDK 53 Query: 85 ---CLKVTEG-----VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 +++ G V+ +F+ A + + +M NN S ++ I Sbjct: 54 EDFLIQIMAGEEFGDVEAIFHEGA---CSSTTEWDGKYMMDNNYQYSKELLHYCLEREIP 110 Query: 137 RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 F YASSA Y ES + +P + YG K +E + + + Sbjct: 111 -FLYASSAATYG------GRTSDFIESREYE-KPLNVYGYSKFLFDEYVRQILPEANSQI 162 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQT--RSFTFIDECVEG 254 R+ N+YGP KG A AF Q + +G + R F ++ + + Sbjct: 163 VGFRYFNVYGPREGHKG--SMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADV 220 Query: 255 VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR 306 L ++ N+G+ S +A+ L++ KK I +IP P+ ++GR Sbjct: 221 NLWFLENGVSGIFNLGTGRAESFQAVADATLAY-HKKGQIEYIPFPDKLKGR 271 >6BI4-A nrPDB Length = 346 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/172 (24%), Positives = 69/172 (40%), Gaps = 8/172 (4%) Query: 167 PAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKA 226 P P Y K + + + Y K + + + R N YGP+ EK A Sbjct: 167 PLAPNSPYSSSKASADMIALAYYKTYQLPVIVTRCSNNYGPYQY----PEKLIPLMVTNA 222 Query: 227 QTSTDRFEMWGDGLQTRSFTFI-DECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVL 285 + ++GDGL R + + D C + L K E NIG + + E+ E ++ Sbjct: 223 -LEGKKLPLYGDGLNVRDWLHVTDHCSAIDVVLHKGRVGEVYNIGGNNEKTNVEVVEQII 281 Query: 286 SFEEK-KLPIHHIPGPEGVRGRNSDN-NLIKEKLGWAPNMRLKEGLRITYFW 335 + K K I ++ G R + N +K + W P ++GL+ T W Sbjct: 282 TLLGKTKKDIEYVTDRLGHDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQW 333 >1KEU-A nrPDB Length = 361 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 72/355 (20%), Positives = 134/355 (37%), Gaps = 69/355 (19%) Query: 28 LKISITGAGGFIASHIAR--------------RLKHEGHYVIASDWKKNEHMTEDM--FC 71 +KI ITG GFI S + R +L + G+ SD ++ + C Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60 Query: 72 DEFHLVDLRVMENCLKVTEGVDHVFNLAAD-------MGGMGFIQSNHSVIMYNNTMISF 124 D + R+ E D V +LAA+ G FI++N + ++ Sbjct: 61 DSAEIT--RIFEQYQP-----DAVMHLAAESHVDRSITGPAAFIETN--------IVGTY 105 Query: 125 NMIEAARI---------NGIKRFFYASSACIY---PEFKQLETTNVSLKESDAWPAEPQD 172 ++E AR RF + S+ +Y P ++E + ++ P Sbjct: 106 ALLEVARKYWSALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSS 165 Query: 173 AYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDR 232 Y K +++ L + + + +G+ + N YGP+ + P + Sbjct: 166 PYSASKASSDHLVRAWRRTYGLPTIVTNCSNNYGPY---HFPEKLIPLVILNALEGKP-- 220 Query: 233 FEMWGDGLQTRSFTFIDECVEGV-LRLTKSDFREPVNIGS-------DEMVS----MNEM 280 ++G G Q R + ++++ + + +T+ E NIG D + + ++E+ Sbjct: 221 LPIYGKGDQIRDWLYVEDHARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEI 280 Query: 281 AEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFW 335 S+ E+ + PG + R D I +LGW P + G+R T W Sbjct: 281 VPKATSYREQITYVADRPGHD--RRYAIDAGKISRELGWKPLETFESGIRKTVEW 333 >2X86-A nrPDB Length = 357 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 65/292 (22%), Positives = 115/292 (39%), Gaps = 37/292 (12%) Query: 30 ISITGAGGFIASHIARRLKHEG--HYVIASDWKKNEHMTEDMFCDEFHLVDLRVMEN--- 84 I +TG GFI S+I + L +G ++ + K +LVDL + + Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFV--------NLVDLNIADYMDK 100 Query: 85 ---CLKVTEG-----VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 +++ G V+ +F+ A + + +M NN S ++ I Sbjct: 101 EDFLIQIMAGEEFGDVEAIFHEGA---CSSTTEWDGKYMMDNNYQYSKELLHYCLEREIP 157 Query: 137 RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 F YASSA Y ES + +P + +G K +E + + + Sbjct: 158 -FLYASSAATYG------GRTSDFIESREYE-KPLNVFGYSKFLFDEYVRQILPEANSQI 209 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQT--RSFTFIDECVEG 254 R+ N+YGP KG A AF Q + +G + R F ++ + + Sbjct: 210 VGFRYFNVYGPREGHKG--SMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADV 267 Query: 255 VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR 306 L ++ N+G+ S +A+ L++ KK I +IP P+ ++GR Sbjct: 268 NLWFLENGVSGIFNLGTGRAESFQAVADATLAY-HKKGQIEYIPFPDKLKGR 318 >1BXK-A nrPDB Length = 355 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 74/348 (21%), Positives = 133/348 (38%), Gaps = 61/348 (17%) Query: 29 KISITGAGGFIASHIAR--------------RLKHEGHYVIASDWKKNEHMTEDM--FCD 72 KI ITG GFI S + R +L + G+ + + ++E + CD Sbjct: 3 KILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICD 62 Query: 73 EFHLVDLRV--MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA 130 L + +C+ HV + + D G FI++N + ++ ++EAA Sbjct: 63 RAELARVFTEHQPDCVMHLAAESHV-DRSID-GPAAFIETN--------IVGTYTLLEAA 112 Query: 131 RI--NGIK-------RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLAT 181 R N + RF + S+ +Y + L +T+ E+ P P Y K ++ Sbjct: 113 RAYWNALTEDKKSAFRFHHISTDEVYGD---LHSTDDFFTETT--PYAPSSPYSASKASS 167 Query: 182 EELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQ 241 + L + + + +G+ I N YGP+ EK A + ++G+G Q Sbjct: 168 DHLVRAWLRTYGLPTLITNCSNNYGPYHF----PEKLIPLMILNA-LAGKSLPVYGNGQQ 222 Query: 242 TRSFTFIDECVEGVLRL-TKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLP------- 293 R + ++++ + + T E NIG ++ E + E+ P Sbjct: 223 IRDWLYVEDHARALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEELAPNKPHGVA 282 Query: 294 -----IHHIPGPEGVRGRNS-DNNLIKEKLGWAPNMRLKEGLRITYFW 335 I + G R + D + I +LG P + G+R T W Sbjct: 283 HYRDLITFVADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQW 330 >6AQY-A nrPDB Length = 341 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 79/190 (41%), Gaps = 14/190 (7%) Query: 78 DLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMY-NNTMISFNMIEAARING 134 DLR + C + E +V +LAA +GG+ F N V + +N ++ N++ G Sbjct: 62 DLRDADACKQPFEKYRPTYVIHLAAFVGGL-FKNMNFKVSFWLDNVNMNNNILTCCYDFG 120 Query: 135 IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI 194 +K+ S C++P+ + T L E P +AY K + L + YN+ Sbjct: 121 VKKTISCLSTCVFPDKIEYPITEEKLHEGP--PHFSNNAYAYAKRMLDMLGRWYNEKAVN 178 Query: 195 ECRIGRF-----HNIYGP---FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFT 246 E + F N++GP F G C KAQ + F ++G G R F Sbjct: 179 EGKSCLFTSVIPTNLFGPHDNFNVEAGHVLPGLMHKCYKAQQNGTDFVVFGSGKPLRQFL 238 Query: 247 FIDECVEGVL 256 + + +L Sbjct: 239 YSHDAARMLL 248 >4WKG-A nrPDB Length = 660 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 63/296 (21%), Positives = 122/296 (41%), Gaps = 31/296 (10%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV--DLRVMENCL 86 ++ I G GFI +H+ RL E HY + ++ ++ + FH V D+ + + Sbjct: 317 RVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWI 376 Query: 87 KV-TEGVDHVFNLAADMGGMGFIQSNHSVIMY----NNTMISFNMIEAARINGIKRFFYA 141 + + D V L A + + ++ V N +I + + KR + Sbjct: 377 EYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYC------VKYRKRIIFP 430 Query: 142 SSACIY----PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECR 197 S++ +Y ++ + +N+ + + +P+ Y + K + + Y + G++ Sbjct: 431 STSEVYGMCSDKYFDEDHSNLIVGPVN----KPRWIYSVSKQLLDRVIWAYGEKEGLQFT 486 Query: 198 IGRFHNIYGP----FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVE 253 + R N GP + G +A + ++ G Q R FT I + +E Sbjct: 487 LFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSP-IKLIDGGKQKRCFTDIRDGIE 545 Query: 254 GVLRLTKSDFR----EPVNIGSDEM-VSMNEMAEMVLSFEEKKLPIHHIPGPEGVR 304 + R+ ++ E +NIG+ E S+ E+ EM+L+ EK HH P G R Sbjct: 546 ALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFR 601 >1ORR-A nrPDB Length = 347 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 79/345 (22%), Positives = 137/345 (39%), Gaps = 38/345 (11%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASD------WKKNEHMTEDMFCDEFHLVDLRVM 82 K+ ITG GF+ S++A +G +I D N H + EF D+R Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLGNFEFVHGDIRNK 62 Query: 83 ENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR-INGIKRFF 139 + ++ D F+LA + I N + N + N++EA R N Sbjct: 63 NDVTRLITKYMPDSCFHLAGQVAMTTSID-NPCMDFEINVGGTLNLLEAVRQYNSNCNII 121 Query: 140 YASSACIYPEFKQL-----ETTNVSLKESDAWPAEPQ----DAYGLEKLATEELCKHYNK 190 Y+S+ +Y + +Q ET + + + + Q YG K A ++ Y + Sbjct: 122 YSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYAR 181 Query: 191 DFGIECRIGRFHNIYG--PFGTWKGGREKAPAAFCRKA----QTSTDRFEMWGDGLQTRS 244 FG+ + R ++YG F T+ G FC+KA F + G+G Q R Sbjct: 182 IFGLNTVVFRHSSMYGGRQFATYDQGW---VGWFCQKAVEIKNGINKPFTISGNGKQVRD 238 Query: 245 FTFIDECVEGVLRLTK----SDFR-EPVNIGSD--EMVSMNEMAEMVLSFEEKKLPIHHI 297 ++ + L T S R NIG +S+ E+ +++ + + ++ Sbjct: 239 VLHAEDMIS--LYFTALANVSKIRGNAFNIGGTIVNSLSLLELFKLLEDYCNIDMRFTNL 296 Query: 298 PGPEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIE 341 P E R +D I + W+P + K+G++ Y W +E Sbjct: 297 PVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTSSILE 341 >2PK3-A nrPDB Length = 321 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 62/314 (19%), Positives = 119/314 (37%), Gaps = 25/314 (7%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 +++ ITG GF+ ++A L + V + + NE ++ E +D+ + Sbjct: 12 SMRALITGVAGFVGKYLANHLTEQNVEVFGTS-RNNEAKLPNV---EMISLDIMDSQRVK 67 Query: 87 KVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK-RFFYASS 143 KV + D++F+LAA + N N + ++++A R + + R S Sbjct: 68 KVISDIKPDYIFHLAAK-SSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTIGS 126 Query: 144 A----CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 + I PE + N P YG+ K + L + Y K +G++ Sbjct: 127 SEEYGMILPEESPVSEEN---------QLRPMSPYGVSKASVGMLARQYVKAYGMDIIHT 177 Query: 200 RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLT 259 R N GP + + + G+ R FT + + V+ L+ Sbjct: 178 RTFNHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLS 237 Query: 260 KSDFREPV-NIGSDEMVSMNEMAEMVLSFEEKKLPIHHIP---GPEGVRGRNSDNNLIKE 315 + V N+ S + ++ +++L+ K+ P P V N +K+ Sbjct: 238 QYGKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKD 297 Query: 316 KLGWAPNMRLKEGL 329 GW P + L++ L Sbjct: 298 STGWKPRIPLEKSL 311 >1Z45-A nrPDB Length = 699 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 74/175 (42%), Gaps = 20/175 (11%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKN---------EHMTEDMF-CDEFHLVDL 79 + +TG G+I SH L G+ + +D N E +T+ E L D Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMY--NNTMISFNMIEAARINGIKR 137 + +E K + +D V + A + +G +S + Y NN + + ++E + + + Sbjct: 74 KGLEKVFKEYK-IDSVIHFAG-LKAVG--ESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKH-YNKD 191 F ++SSA +Y + + + + P P + YG K A E + YN D Sbjct: 130 FVFSSSATVYGDATRFPNM---IPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 >4R1U-A nrPDB Length = 349 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 13/121 (10%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS----DWKKNEHMTEDMFCDE---FHLVDLRVM 82 + +TGAGGFIAS + + L G+ V + + KN H+ E E H VDL + Sbjct: 30 VCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEGARERLTLHKVDLLDL 89 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 ++ V G VF+ A+ + N ++ + N+I A+ ++R + S Sbjct: 90 QSIQSVVHGCHGVFHTASP------VTDNPDEMLEPAVNGTKNVIIASAEAKVRRVVFTS 143 Query: 143 S 143 S Sbjct: 144 S 144 >4R1T-A nrPDB Length = 337 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 13/121 (10%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS----DWKKNEHMTEDMFCDE---FHLVDLRVM 82 + +TGAGGFIAS + + L +G+ V + D KN H+ E E DL Sbjct: 13 VCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELEGAKERLTLCKADLLDY 72 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 ++ + G D VF+ A+ + + ++ + + N+I AA ++R + S Sbjct: 73 QSLREAINGCDGVFHTASP------VTDDPEQMVEPAVIGTKNVINAAAEANVRRVVFTS 126 Query: 143 S 143 S Sbjct: 127 S 127 >4QUK-A nrPDB Length = 319 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 26/43 (60%), Gaps = 5/43 (11%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS-----DWKKNEHMTE 67 + +TGA G+IAS + R L H G+ V A+ D KK +H+ + Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVK 45 >1GY8-A nrPDB Length = 397 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 77/383 (20%), Positives = 135/383 (35%), Gaps = 97/383 (25%) Query: 27 NLKISITGAGGFIASHIARRL-KHEGHYVIASDWKKNEHMTEDM---------------- 69 ++++ + G G+I SH R L + H V+ D H D Sbjct: 2 HMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDG 61 Query: 70 ----FCDEFHLVDLRVMEN------CLKVTEGVDHVFNLAADMGGMGFIQSNHSV---IM 116 + D + +++ + N +D V ++ A F+ SV + Sbjct: 62 PKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCA------FLAVGESVRDPLK 115 Query: 117 Y--NNTMISFNMIEAARINGIKRFFYASSACIY--PEFKQLETT----NVSLKESDAWPA 168 Y NN + +++A ++ + ++SSA I+ P + T +++ K+S Sbjct: 116 YYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKS----- 170 Query: 169 EPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGT------WKGGREKAPAAF 222 P+ YG KL E + + + +GI+ R+ N G ++G P Sbjct: 171 -PESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIIL 229 Query: 223 CR-------------KAQTSTD-RFEMWG------DGLQTRSFTFI-DECVEGVLRL--- 258 R STD R ++G DG R + + D +L L Sbjct: 230 GRVMSDIAPDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYV 289 Query: 259 ------TKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNL 312 KS + N+G+ S+ E+ E+ +K H IP E R L Sbjct: 290 EKLGPNDKSKYFSVFNLGTSRGYSVREVIEVA-----RKTTGHPIPVRECGRREGDPAYL 344 Query: 313 I------KEKLGWAPNMRLKEGL 329 + +E LGW P E + Sbjct: 345 VAASDKAREVLGWKPKYDTLEAI 367 >4QQR-A nrPDB Length = 301 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 69/192 (35%), Gaps = 21/192 (10%) Query: 94 HVFNLAADMG--GMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYPEFK 151 HVFN A G + + +S+ + N + + + R G+ YA+ + Sbjct: 63 HVFNAAGVTGRPNVDWCESHKVETIRTNVAGTLTLADICREKGLVLINYATGCIFEYDSG 122 Query: 152 QLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGTW 211 + + KE D P Y K EEL K+Y + R+ ++ P Sbjct: 123 HPLGSGIGFKEEDT-PNFTGSFYSKTKAMVEELLKNYENVCTLRVRMPISSDLTNP---- 177 Query: 212 KGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVNIGS 271 R T R+E D S T +DE + + + K + N + Sbjct: 178 ------------RNFITKIARYEKVVD--IPNSMTILDELLPISIEMAKRNLTGIYNFTN 223 Query: 272 DEMVSMNEMAEM 283 +VS NE+ EM Sbjct: 224 PGVVSHNEILEM 235 >2NNL-D nrPDB Length = 337 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 35/129 (27%), Positives = 56/129 (43%), Gaps = 11/129 (8%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHYVIA-----SDWKKNEHMTEDMFCDEFHLV-- 77 S++ + +TGA GFI S + RL G+ V A ++ KK +H+ D+ E HL Sbjct: 3 SQSETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLL-DLPKAETHLTLW 61 Query: 78 --DLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGI 135 DL + + +G VF++A M N + M+ M A + Sbjct: 62 KADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGI-MKSCAAAKTV 120 Query: 136 KRFFYASSA 144 +R + SSA Sbjct: 121 RRLVFTSSA 129 >3ENK-A nrPDB Length = 341 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 23/169 (13%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-------FHLVDLRVM 82 I +TG G+I SH A L G+ V+ +D N ++ FH D+ Sbjct: 8 ILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSDE 67 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFI-QSNHSVIMY--NNTMISFNMIEAARINGIKRFF 139 ++ + H A + + +S I Y NN +++ R +KR Sbjct: 68 RALARIFDA--HPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERAVKRIV 125 Query: 140 YASSACIY--PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCK 186 ++SSA +Y PE ++ T +P + YG KL E++ + Sbjct: 126 FSSSATVYGVPERSPIDET---------FPLSATNPYGQTKLMAEQILR 165 >5B6K-A nrPDB Length = 366 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 26/43 (60%), Gaps = 2/43 (4%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS--DWKKNEHMTEDMF 70 + ++GA GFIA H+ R+L + + VI S +K +H+ +F Sbjct: 24 VFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIF 66 >4J2O-A nrPDB Length = 363 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 59/123 (47%), Gaps = 7/123 (5%) Query: 32 ITGAGGFIASHIARRLKH---EGHYVIASDWKKNEHMTEDMFCDE--FHLVDLRVMENCL 86 ITG G + + +R + + + D KK + M + + F++ D+R + L Sbjct: 28 ITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKKYHSAKLKFYIGDVRDYNSIL 87 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASS-AC 145 T GVD++++ AA + + + + + N + + N++EAA N +KR S+ Sbjct: 88 NATRGVDYIYHAAA-LKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNHVKRVVCLSTDKA 146 Query: 146 IYP 148 +YP Sbjct: 147 VYP 149 >1C8U-A nrPDB Length = 285 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 3/83 (3%) Query: 123 SFNMIEAARINGIKRFFYASSACIYPE--FKQLETTNVSLKESDAWPAEPQDAYGLEKLA 180 SF+ A I K FY +++ PE F+ + T S D P+E Q A L L Sbjct: 85 SFSARRVAAIQNGKPIFYMTASFQAPEAGFEH-QKTMPSAPAPDGLPSETQIAQSLAHLL 143 Query: 181 TEELCKHYNKDFGIECRIGRFHN 203 L + D +E R FHN Sbjct: 144 PPVLKDKFICDRPLEVRPVEFHN 166 >4PVC-A nrPDB Length = 342 Score = 31.6 bits (70), Expect = 0.52, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 25/42 (59%), Gaps = 2/42 (4%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIAS--DWKKNEHMTE 67 + + ++GA GFIA HI L E + VI S +K E++TE Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTE 42 >1ZZE-A nrPDB Length = 342 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 11/25 (44%), Positives = 17/25 (68%) Query: 30 ISITGAGGFIASHIARRLKHEGHYV 54 + +TGA GF+ASH+ +L G+ V Sbjct: 14 VLVTGANGFVASHVVEQLLEHGYKV 38 >2F6R-A nrPDB Length = 281 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 21/35 (60%) Query: 24 PSENLKISITGAGGFIASHIARRLKHEGHYVIASD 58 PS + +TG G S +A+RLK+ G Y+I SD Sbjct: 72 PSGLYVLGLTGISGSGKSSVAQRLKNLGAYIIDSD 106 >4KCA-A nrPDB Length = 692 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 21/44 (47%) Query: 168 AEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFGTW 211 +E D L+ T+ + Y DFG + R NI+G +G W Sbjct: 418 SEKPDGPYLDARGTDAVFASYKLDFGPDANDNRGVNIFGAYGDW 461 >1RPN-A nrPDB Length = 335 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 60/318 (18%), Positives = 131/318 (41%), Gaps = 31/318 (9%) Query: 32 ITGAGGFIASHIARRLKHEG---HYVIA-----SDWKKNEHMTE-DMFCDEFHLVDLRVM 82 +TG G +++A+ L +G H ++A + W+ E E D+ ++ + D + Sbjct: 19 VTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGDIQYEDGDMADACSV 78 Query: 83 ENCLKVTEGVDHVFNLAAD-MGGMGFIQSNHSVIMYNNTMISFNMIEAAR-INGIKRFFY 140 + + + V+NLAA G + Q + ++ + + +++EA R + RF+ Sbjct: 79 QRAV-IKAQPQEVYNLAAQSFVGASWNQPVTTGVV--DGLGVTHLLEAIRQFSPETRFYQ 135 Query: 141 ASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGR 200 AS++ ++ + + ++ + P P+ YG+ KL + +Y + FG+ G Sbjct: 136 ASTSEMFGLIQ-------AERQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHASSGI 188 Query: 201 FHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTK 260 N P + K A R + G+ R + F + VE + + + Sbjct: 189 LFNHESPLRGIEFVTRKVTDAVARIKLGKQQELRL-GNVDAKRDWGFAGDYVEAMWLMLQ 247 Query: 261 SDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLI------- 313 D + + + ++ +M + ++FE L + R ++ +++ Sbjct: 248 QDKADDYVVATGVTTTVRDMCQ--IAFEHVGLDYRDFLKIDPAFFRPAEVDVLLGNPAKA 305 Query: 314 KEKLGWAPNMRLKEGLRI 331 + LGW P L E +R+ Sbjct: 306 QRVLGWKPRTSLDELIRM 323 >5VT6-A nrPDB Length = 269 Score = 28.5 bits (62), Expect = 5.6, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 7/68 (10%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMT------EDMFCD-EFHLVDLRVMEN 84 +TG G + + I+RRL G V S ++N+H++ D D + + VD+ E+ Sbjct: 30 VTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVDVADFES 89 Query: 85 CLKVTEGV 92 C + E V Sbjct: 90 CERCAEKV 97 >5UPR-A nrPDB Length = 265 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 24/47 (51%), Gaps = 5/47 (10%) Query: 151 KQLETTNVSLKESDAWPA-----EPQDAYGLEKLATEELCKHYNKDF 192 +QLE ++ E+DAW + EP A G K AT L + ++D Sbjct: 156 EQLEAVRQAVPEADAWKSIVIAYEPVWAIGTGKTATAALAQETHRDI 202 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2C54-A nrPDB 527 e-150 1R66-A nrPDB 277 5e-75 2HUN-A nrPDB 275 3e-74 6BWL-A nrPDB 271 3e-73 1KEU-A nrPDB 262 2e-70 1BXK-A nrPDB 259 1e-69 1OC2-A nrPDB 258 4e-69 1GFS-A nrPDB 256 1e-68 6BI4-A nrPDB 248 4e-66 2C20-A nrPDB 243 1e-64 1ORR-A nrPDB 240 1e-63 3SXP-A nrPDB 239 2e-63 1UDA-A nrPDB 236 1e-62 2Q1T-A nrPDB 235 3e-62 4WOK-A nrPDB 228 2e-60 3M2P-A nrPDB 221 4e-58 3RUE-A nrPDB 218 2e-57 1EQ2-A nrPDB 215 2e-56 4EJ0-A nrPDB 215 2e-56 2X86-A nrPDB 214 5e-56 4WKG-A nrPDB 211 5e-55 6AQY-A nrPDB 178 4e-45 3RFT-A nrPDB 140 1e-33 3WMX-A nrPDB 131 5e-31 Sequences not found previously or not previously below threshold: 1Z45-A nrPDB 181 3e-46 1I3M-A nrPDB 180 8e-46 4LIS-A nrPDB 175 3e-44 1GY8-A nrPDB 173 1e-43 3ENK-A nrPDB 165 3e-41 2PK3-A nrPDB 156 2e-38 4BKP-A nrPDB 147 6e-36 2PZM-A nrPDB 145 4e-35 1DB3-A nrPDB 133 1e-31 2Q1W-A nrPDB 131 6e-31 1N7G-A nrPDB 118 3e-27 2Z95-A nrPDB 115 4e-26 5UZH-A nrPDB 113 1e-25 6GPK-A nrPDB 112 2e-25 1RPN-A nrPDB 102 2e-22 2NNL-D nrPDB 102 2e-22 1WVG-A nrPDB 96 3e-20 4R1T-A nrPDB 93 2e-19 2P4H-X nrPDB 90 1e-18 1RKX-A nrPDB 89 2e-18 2GN9-A nrPDB 89 2e-18 4J2O-A nrPDB 86 3e-17 4G5H-A nrPDB 82 4e-16 1VL0-A nrPDB 81 6e-16 3HFS-A nrPDB 81 8e-16 4R1U-A nrPDB 81 1e-15 4KTT-E nrPDB 81 1e-15 3SC6-A nrPDB 77 1e-14 4QUK-A nrPDB 76 2e-14 4WPG-A nrPDB 69 3e-12 5U9C-A nrPDB 69 4e-12 4PVC-A nrPDB 68 8e-12 5B6K-A nrPDB 65 5e-11 6GCS-E nrPDB 64 8e-11 1ZZE-A nrPDB 61 6e-10 2GGS-A nrPDB 60 2e-09 1KC3-A nrPDB 58 6e-09 4QQR-A nrPDB 57 1e-08 5YWN-A nrPDB 48 5e-06 6G2J-P nrPDB 47 1e-05 4B4O-A nrPDB 46 3e-05 3PVZ-A nrPDB 44 1e-04 5GUP-L nrPDB 44 1e-04 5OVL-A nrPDB 43 2e-04 5OVJ-A nrPDB 43 2e-04 2QYS-A nrPDB 43 2e-04 1UZM-A nrPDB 42 3e-04 1CYD-A nrPDB 42 4e-04 4NBT-A nrPDB 41 6e-04 2Q4B-A nrPDB 41 6e-04 1N5D-A nrPDB 41 7e-04 2DKN-A nrPDB 41 9e-04 2NM0-A nrPDB 40 0.001 4AVY-A nrPDB 40 0.002 1AE1-A nrPDB 40 0.002 1BDB-A nrPDB 40 0.002 2V6G-A nrPDB 40 0.002 1QYC-A nrPDB 39 0.003 5ITV-A nrPDB 39 0.003 5MLM-A nrPDB 39 0.005 4K6F-A nrPDB 39 0.005 5VT6-A nrPDB 38 0.005 5NUE-A nrPDB 38 0.006 1OOE-A nrPDB 38 0.007 2HRB-A nrPDB 38 0.007 3DWF-A nrPDB 38 0.009 3VZS-A nrPDB 37 0.014 5F5N-A nrPDB 37 0.015 1QYD-A nrPDB 37 0.019 3SLK-A nrPDB 36 0.020 1GEG-A nrPDB 36 0.021 3ZV3-A nrPDB 36 0.022 3ORF-A nrPDB 36 0.023 3UN1-A nrPDB 36 0.026 4E0B-A nrPDB 36 0.026 3EZL-A nrPDB 36 0.028 4F3Y-A nrPDB 36 0.032 4RZI-B nrPDB 36 0.036 5PGZ-A nrPDB 36 0.039 3BHI-A nrPDB 36 0.041 3TQH-A nrPDB 35 0.047 3RWB-A nrPDB 35 0.054 1IE3-A nrPDB 35 0.056 3A28-C nrPDB 35 0.066 5TQV-A nrPDB 35 0.068 2ZAT-A nrPDB 34 0.075 2HSD-A nrPDB 34 0.079 2AE2-A nrPDB 34 0.080 3U5T-A nrPDB 34 0.084 3F9I-A nrPDB 34 0.086 3OEC-A nrPDB 34 0.092 4UUP-A nrPDB 34 0.093 3KYB-A nrPDB 34 0.096 4CR6-A nrPDB 34 0.10 3FTP-A nrPDB 34 0.11 5T5Q-A nrPDB 34 0.14 4JRO-A nrPDB 34 0.15 4IIV-A nrPDB 34 0.16 2PH3-A nrPDB 33 0.17 3V2G-A nrPDB 33 0.18 3U9L-A nrPDB 33 0.22 3PPI-A nrPDB 33 0.24 2GAS-A nrPDB 33 0.25 5TEN-A nrPDB 33 0.28 4I1I-A nrPDB 32 0.29 2GDZ-A nrPDB 32 0.30 3D3W-A nrPDB 32 0.32 1DIR-A nrPDB 32 0.39 3UW3-A nrPDB 32 0.40 7MDH-A nrPDB 32 0.42 4G65-A nrPDB 32 0.44 3MJ4-A nrPDB 32 0.44 2G17-A nrPDB 32 0.48 3WOH-A nrPDB 32 0.49 2LDB-A nrPDB 32 0.56 4J6F-A nrPDB 32 0.56 5LCX-A nrPDB 32 0.57 3WYE-A nrPDB 32 0.59 3Q7I-A nrPDB 32 0.59 3CLW-A nrPDB 32 0.62 3PXX-A nrPDB 31 0.65 2O23-A nrPDB 31 0.67 3GRP-A nrPDB 31 0.68 6BAL-A nrPDB 31 0.70 1CIV-A nrPDB 31 0.71 4MOW-A nrPDB 31 0.74 2X9N-A nrPDB 31 0.81 4NBV-A nrPDB 31 0.84 4UUO-A nrPDB 31 0.85 4E6P-A nrPDB 31 0.91 2PNF-A nrPDB 31 0.98 3WTC-A nrPDB 31 1.0 1RY6-A nrPDB 31 1.0 4BPC-A nrPDB 31 1.1 4TVO-A nrPDB 31 1.4 4KMS-A nrPDB 31 1.4 1YXM-A nrPDB 30 1.5 2PV7-A nrPDB 30 1.6 1JAY-A nrPDB 30 1.7 1O89-A nrPDB 30 1.7 4V7E-CC nrPDB 30 1.7 4V3P-LD nrPDB 30 1.7 6NRP-A nrPDB 30 1.8 5ER0-A nrPDB 30 1.9 5IZ4-A nrPDB 30 1.9 5B1Y-A nrPDB 30 2.0 4DVJ-A nrPDB 30 2.0 3OSU-A nrPDB 30 2.1 2BC1-A nrPDB 30 2.2 5GXF-A nrPDB 30 2.2 3RSH-A nrPDB 29 2.4 3KZV-A nrPDB 29 2.5 2YQ5-A nrPDB 29 2.5 6CI9-A nrPDB 29 2.7 3FI9-A nrPDB 29 3.0 3G4D-A nrPDB 29 3.6 4WLE-A nrPDB 29 4.4 4LE5-A nrPDB 29 4.4 1NSY-A nrPDB 29 4.8 5UGJ-A nrPDB 29 4.9 6BDX-A nrPDB 28 5.4 2UVD-A nrPDB 28 7.0 1QO8-A nrPDB 27 9.6 >2C54-A nrPDB Length = 379 Score = 527 bits (1356), Expect = e-150, Method: Composition-based stats. Identities = 376/377 (99%), Positives = 377/377 (100%) Query: 1 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK 60 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK Sbjct: 3 MGTTNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWK 62 Query: 61 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT 120 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT Sbjct: 63 KNEHMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT 122 Query: 121 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLA 180 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLE+LA Sbjct: 123 MISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLERLA 182 Query: 181 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL 240 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL Sbjct: 183 TEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL 242 Query: 241 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 300 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP Sbjct: 243 QTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 302 Query: 301 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG 360 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG Sbjct: 303 EGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVG 362 Query: 361 TQAPVQLGSLRAADGKE 377 TQAPVQLGSLRAADGKE Sbjct: 363 TQAPVQLGSLRAADGKE 379 >1R66-A nrPDB Length = 337 Score = 277 bits (708), Expect = 5e-75, Method: Composition-based stats. Identities = 75/327 (22%), Positives = 129/327 (39%), Gaps = 28/327 (8%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASD---------WKKNEHMTEDMFCD---EFH 75 +++ +TG GFI SH R+L + + +D + N + D F Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRLRFV 60 Query: 76 LVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGI 135 D+R + GVD + + AA+ I + SV N + +++ A G+ Sbjct: 61 HGDIRDAGLLARELRGVDAIVHFAAESHVDRSI-AGASVFTETNVQGTQTLLQCAVDAGV 119 Query: 136 KRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIE 195 R + S+ +Y T S P EP Y K ++ + + Y++ +G++ Sbjct: 120 GRVVHVSTDEVYGSIDSGSWTESS-------PLEPNSPYAASKAGSDLVARAYHRTYGLD 172 Query: 196 CRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV 255 RI R N YGP+ EK F ++GDG R + D+ G+ Sbjct: 173 VRITRCCNNYGPYQ----HPEKLIPLFVTNL-LDGGTLPLYGDGANVREWVHTDDHCRGI 227 Query: 256 -LRLTKSDFREPVNIGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNS-DNNL 312 L L E +IG ++ E+ ++L S + + +G R S D Sbjct: 228 ALVLAGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSSVRKVADRKGHDLRYSLDGGK 287 Query: 313 IKEKLGWAPNMRLKEGLRITYFWIKEQ 339 I+ +LG+ P + +GL T W +E Sbjct: 288 IERELGYRPQVSFADGLARTVRWYREN 314 >2HUN-A nrPDB Length = 336 Score = 275 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 78/325 (24%), Positives = 139/325 (42%), Gaps = 25/325 (7%) Query: 27 NLKISITGAGGFIASHIARRLK--HEGHYVIASD---WKKNEHMTEDMFCDE---FHLVD 78 ++K+ +TG GFI S+ R + H VI D + N +D+ D F D Sbjct: 3 SMKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDDPRYTFVKGD 62 Query: 79 LRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR-INGIKR 137 + E ++ VD V +LAA+ I S + +++N + ++ ++E+ R N R Sbjct: 63 VADYELVKELVRKVDGVVHLAAESHVDRSISS-PEIFLHSNVIGTYTLLESIRRENPEVR 121 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECR 197 F + S+ +Y + + S E+D P Y K A++ L + + + + Sbjct: 122 FVHVSTDEVYGDILKG-----SFTENDR--LMPSSPYSATKAASDMLVLGWTRTYNLNAS 174 Query: 198 IGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV-L 256 I R N YGP+ + P R + + ++G G R + ++++ V + L Sbjct: 175 ITRCTNNYGPYQF---PEKLIPKTIIRASLGL--KIPIYGTGKNVRDWLYVEDHVRAIEL 229 Query: 257 RLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEK-KLPIHHIPGPEGVRGRNS-DNNLIK 314 L K + RE NI + E + E+ +++L K + I + G R S D+ I Sbjct: 230 VLLKGESREIYNISAGEEKTNLEVVKIILRLMGKGEELIELVEDRPGHDLRYSLDSWKIT 289 Query: 315 EKLGWAPNMRLKEGLRITYFWIKEQ 339 L W P EG++ T W + Sbjct: 290 RDLKWRPKYTFDEGIKKTIDWYLKN 314 >6BWL-A nrPDB Length = 328 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 137/321 (42%), Gaps = 20/321 (6%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKN------EHMTEDMFCDEFHLVDLRV 81 +KI +TG GFI + +RL + H V D N D+ + D++ Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQCIQGDIKD 60 Query: 82 MENCLKVTEG--VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 + ++ E D ++LAA + I + N+T+ +FN++E +N + Sbjct: 61 KKLVAQLFENNSFDLCYHLAASINVQDSIDDARATF-ENDTIGTFNLLEQC-LNYDVKMV 118 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 + S+ +Y + ++ S+ P +P Y K+A E + Y + + + Sbjct: 119 FMSTCMVYDKATNIQGI------SELDPIKPASPYAGSKIAAENMVLSYYYAYKLPVVVI 172 Query: 200 RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLT 259 R N YGPF K G E A + ++GDG QTR ++++C + V+ Sbjct: 173 RPFNTYGPFQ--KTGGEGGVVAIFINNKLDNVPLNIYGDGKQTRDLLYVEDCADFVVAAG 230 Query: 260 KSDF--REPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKL 317 S +N G+ + +S+N++AE++ + + HI ++ + K L Sbjct: 231 YSAKANGHIINAGTGQDISINKLAELISGNKVSIQHVTHIHPQSEIQKLLCNYEKAKTIL 290 Query: 318 GWAPNMRLKEGLRITYFWIKE 338 W P + L++G+ T WIK Sbjct: 291 NWEPKVSLEDGVIKTEEWIKS 311 >1KEU-A nrPDB Length = 361 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 70/374 (18%), Positives = 134/374 (35%), Gaps = 52/374 (13%) Query: 28 LKISITGAGGFIASHIAR--------------RLKHEGHYVIASDWKKNEHMTEDMFCDE 73 +KI ITG GFI S + R +L + G+ SD ++ Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYN------- 53 Query: 74 FHLVDLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR 131 F D+ ++ E D V +LAA+ I + + + N + ++ ++E AR Sbjct: 54 FEHADICDSAEITRIFEQYQPDAVMHLAAESHVDRSI-TGPAAFIETNIVGTYALLEVAR 112 Query: 132 I---------NGIKRFFYASSACIYPEFK---QLETTNVSLKESDAWPAEPQDAYGLEKL 179 RF + S+ +Y + ++E + ++ P Y K Sbjct: 113 KYWSALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKA 172 Query: 180 ATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDG 239 +++ L + + + +G+ + N YGP+ EK A ++G G Sbjct: 173 SSDHLVRAWRRTYGLPTIVTNCSNNYGPYHF----PEKLIPLVILNA-LEGKPLPIYGKG 227 Query: 240 LQTRSFTFIDECVEGV-LRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLP----- 293 Q R + ++++ + + +T+ E NIG ++ + ++ +P Sbjct: 228 DQIRDWLYVEDHARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSY 287 Query: 294 ---IHHIPGPEGVRGRNS-DNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIE-KEKAKGS 348 I ++ G R + D I +LGW P + G+R T W + K Sbjct: 288 REQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQWVNNVKSG 347 Query: 349 DVSLYGSSKVVGTQ 362 + G Q Sbjct: 348 AYQSWIEQNYEGRQ 361 >1BXK-A nrPDB Length = 355 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 75/343 (21%), Positives = 129/343 (37%), Gaps = 43/343 (12%) Query: 29 KISITGAGGFIASHIARRLKHE-GHYVIASD---WKKNEHMTEDMFCDE---FHLVDLRV 81 KI ITG GFI S + R + +E V+ D + N + E F VD+ Sbjct: 3 KILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICD 62 Query: 82 MENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARI------- 132 +V D V +LAA+ I + + N + ++ ++EAAR Sbjct: 63 RAELARVFTEHQPDCVMHLAAESHVDRSID-GPAAFIETNIVGTYTLLEAARAYWNALTE 121 Query: 133 --NGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNK 190 RF + S+ +Y + L +T+ E+ P P Y K +++ L + + + Sbjct: 122 DKKSAFRFHHISTDEVYGD---LHSTDDFFTETT--PYAPSSPYSASKASSDHLVRAWLR 176 Query: 191 DFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDE 250 +G+ I N YGP+ EK A + ++G+G Q R + ++++ Sbjct: 177 TYGLPTLITNCSNNYGPYHF----PEKLIPLMILNA-LAGKSLPVYGNGQQIRDWLYVED 231 Query: 251 CVEGVLRL-TKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLP------------IHHI 297 + + T E NIG ++ E + E+ P I + Sbjct: 232 HARALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEELAPNKPHGVAHYRDLITFV 291 Query: 298 PGPEGVRGRNS-DNNLIKEKLGWAPNMRLKEGLRITYFWIKEQ 339 G R + D + I +LG P + G+R T W Sbjct: 292 ADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQWYLAN 334 >1OC2-A nrPDB Length = 348 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 84/352 (23%), Positives = 143/352 (40%), Gaps = 33/352 (9%) Query: 25 SENLKISITGAGGFIASHIARRL--KHEGHYVIASD---WKKNEHMTEDMFCDEFHLV-- 77 S+ I +TG GFI S+ + H +V D + N+ E + D LV Sbjct: 2 SQFKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVELVVG 61 Query: 78 DLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKR 137 D+ E K+ D + + AA+ + + S ++ N + ++ ++EAAR I R Sbjct: 62 DIADAELVDKLAAKADAIVHYAAESHNDNSLN-DPSPFIHTNFIGTYTLLEAARKYDI-R 119 Query: 138 FFYASSACIYPEFKQLE-----TTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDF 192 F + S+ +Y + E K + P Y K A++ + K + + F Sbjct: 120 FHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIVKAWVRSF 179 Query: 193 GIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECV 252 G++ I N YGP+ EK + + +++G+G R + ++ Sbjct: 180 GVKATISNCSNNYGPYQ----HIEKFIPRQITN-ILAGIKPKLYGEGKNVRDWIHTNDHS 234 Query: 253 EGVLR-LTKSDFREPVNIGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNS-D 309 GV LTK E IG+D + E+ E++L + K H+ G R + D Sbjct: 235 TGVWAILTKGRMGETYLIGADGEKNNKEVLELILEKMGQPKDAYDHVTDRAGHDLRYAID 294 Query: 310 NNLIKEKLGWAPNMR-LKEGLRITYFWI----------KEQIEKEKAKGSDV 350 + ++++LGW P EGL T W KE +E AK +V Sbjct: 295 ASKLRDELGWTPQFTDFSEGLEETIQWYTDNQDWWKAEKEAVEANYAKTQEV 346 >1GFS-A nrPDB Length = 321 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 140/333 (42%), Gaps = 30/333 (9%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 ++ I G G + S I R+L+ G + + DE +L+D R + + Sbjct: 4 QRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTR-----------DELNLLDSRAVHDFF- 51 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 +E +D V+ AA +GG+ + + +Y N MI N+I AA N + + + S+CIY Sbjct: 52 ASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKLLFLGSSCIY 111 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 P+ + L + P + Y + K+A +LC+ YN+ +G + R N+YGP Sbjct: 112 PKLAKQPMAESELLQGTLEPT--NEPYAIAKIAGIKLCESYNRQYGRDYRSVMPTNLYGP 169 Query: 208 FGTWKGGREKAPAAFCRK----AQTSTDRFEMWGDGLQTRSFTFIDECVEG---VLRLTK 260 + A R+ + +WG G R F +D+ V+ L Sbjct: 170 HDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMAAASIHVMELAH 229 Query: 261 SDFRE-------PVNIGSDEMVSMNEMAEMVLS-FEEKKLPIHHIPGPEGVRGRNSDNNL 312 + E +N+G+ ++ E+A+ + K + P+G + D Sbjct: 230 EVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASKPDGTPRKLLDVTR 289 Query: 313 IKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKA 345 + +LGW + L+ GL TY W E ++ + Sbjct: 290 L-HQLGWYHEISLEAGLASTYQWFLENQDRFRG 321 >6BI4-A nrPDB Length = 346 Score = 248 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 67/333 (20%), Positives = 126/333 (37%), Gaps = 25/333 (7%) Query: 22 YWPSENLKISITGAGGFIASHIARRLK--HEGHYVIASD------WKKNEHMTEDMFCDE 73 Y+ S + I +TG GFI S+ + +E + +I D N +D Sbjct: 19 YFQSNAMNILVTGGAGFIGSNFVHYMLQSYETYKIINFDALTYSGNLNNVKSIQDHPNYY 78 Query: 74 FHLVDLRVMENCLKVTEGVDH--VFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR 131 F +++ E V + D + N AA+ I+ N N + + ++E + Sbjct: 79 FVKGEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIE-NPIPFYDTNVIGTVTLLELVK 137 Query: 132 INGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 + S+ +Y + ++ P P Y K + + + Y K Sbjct: 138 KYPHIKLVQVSTDEVYGSLGKTGR------FTEETPLAPNSPYSSSKASADMIALAYYKT 191 Query: 192 FGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDEC 251 + + + R N YGP+ EK A + ++GDGL R + + + Sbjct: 192 YQLPVIVTRCSNNYGPYQY----PEKLIPLMVTNA-LEGKKLPLYGDGLNVRDWLHVTDH 246 Query: 252 VEGV-LRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEK-KLPIHHIPGPEGVRGRNS- 308 + + L K E NIG + + E+ E +++ K K I ++ G R + Sbjct: 247 CSAIDVVLHKGRVGEVYNIGGNNEKTNVEVVEQIITLLGKTKKDIEYVTDRLGHDRRYAI 306 Query: 309 DNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIE 341 + +K + W P ++GL+ T W ++ E Sbjct: 307 NAEKMKNEFDWEPKYTFEQGLQETVQWYEKNEE 339 >2C20-A nrPDB Length = 330 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 75/329 (22%), Positives = 131/329 (39%), Gaps = 27/329 (8%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV- 88 I I G G+I SH ++L EG V+ D + H +F+ DLR V Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLRDVF 63 Query: 89 -TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 E ++ V + AAD ++ NN + ++E + +F ++S+A Y Sbjct: 64 TQENIEAVMHFAADSLVGVSMEK-PLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAATY 122 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 E +V L + P + YG KLA E++ Y++ + +I R+ N+ G Sbjct: 123 GE------VDVDLITEETM-TNPTNTYGETKLAIEKMLHWYSQASNLRYKIFRYFNVAGA 175 Query: 208 FGTWKGGREKAP-----AAFCRKAQTSTDRFEMWGDGLQT------RSFTFIDECVE--- 253 G + P + A ++ M+GD T R + +++ V Sbjct: 176 TPNGIIGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHF 235 Query: 254 -GVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR-NSDNN 311 G+ L + N+G+ S+ E+ + V ++P P G R + + Sbjct: 236 LGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQ 295 Query: 312 LIKEKLGWAPNM-RLKEGLRITYFWIKEQ 339 KEKLGW P +K + + W ++Q Sbjct: 296 KAKEKLGWDPRYVNVKTIIEHAWNWHQKQ 324 >1ORR-A nrPDB Length = 347 Score = 240 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 72/341 (21%), Positives = 132/341 (38%), Gaps = 30/341 (8%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKK------NEHMTEDMFCDEFHLVDLRVM 82 K+ ITG GF+ S++A +G +I D N H + EF D+R Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLGNFEFVHGDIRNK 62 Query: 83 ENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARI-NGIKRFF 139 + ++ D F+LA + I N + N + N++EA R N Sbjct: 63 NDVTRLITKYMPDSCFHLAGQVAMTTSID-NPCMDFEINVGGTLNLLEAVRQYNSNCNII 121 Query: 140 YASSACIYPEFKQL-----ETTNVSLKESDAWPAEPQ----DAYGLEKLATEELCKHYNK 190 Y+S+ +Y + +Q ET + + + + Q YG K A ++ Y + Sbjct: 122 YSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYAR 181 Query: 191 DFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQ----TSTDRFEMWGDGLQTRSFT 246 FG+ + R ++YG + + FC+KA F + G+G Q R Sbjct: 182 IFGLNTVVFRHSSMYGGRQ-FATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDVL 240 Query: 247 FIDECVEGVLRLTKSDF---REPVNIGSD--EMVSMNEMAEMVLSFEEKKLPIHHIPGPE 301 ++ + + NIG +S+ E+ +++ + + ++P E Sbjct: 241 HAEDMISLYFTALANVSKIRGNAFNIGGTIVNSLSLLELFKLLEDYCNIDMRFTNLPVRE 300 Query: 302 -GVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIE 341 R +D I + W+P + K+G++ Y W +E Sbjct: 301 SDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTSSILE 341 >3SXP-A nrPDB Length = 362 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 78/366 (21%), Positives = 140/366 (38%), Gaps = 49/366 (13%) Query: 26 ENLKISITGAGGFIASHIARRLKH---EGHYVIASDWKKNEHMT---------------- 66 EN I ITG GF+ S++A + + V+ ++ N + Sbjct: 9 ENQTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIGF 68 Query: 67 --EDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISF 124 E + D + +DLR +E D++F+ AA N ++M N Sbjct: 69 KGEVIAADINNPLDLRRLEKL-----HFDYLFHQAAVSDTTML---NQELVMKTNYQAFL 120 Query: 125 NMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEEL 184 N++E AR + YASSA +Y K P++ YG KL +E Sbjct: 121 NLLEIARSKKA-KVIYASSAGVYGNTKA--------PNVVGKNESPENVYGFSKLCMDEF 171 Query: 185 CKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRS 244 ++ D R+ N+YGP +K A + +++ G Q R Sbjct: 172 VLSHSNDNVQ--VGLRYFNVYGPREFYKEKTASMVLQLALGA-MAFKEVKLFEFGEQLRD 228 Query: 245 FTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVR 304 F +I++ ++ ++ K+ N+G + S NE+ +L + +I P Sbjct: 229 FVYIEDVIQANVKAMKAQKSGVYNVGYSQARSYNEIVS-ILKEHLGDFKVTYIKNPYAFF 287 Query: 305 GRNSDNNL--IKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVGTQ 362 +++ ++ L + P L+ G++ I + ++AKG +SK+ G Sbjct: 288 QKHTQAHIEPTILDLDYTPLYDLESGIKDYLPHIHAIFKGQRAKGE-----LNSKLEGKP 342 Query: 363 APVQLG 368 P LG Sbjct: 343 IPNLLG 348 >1UDA-A nrPDB Length = 338 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 122/336 (36%), Gaps = 36/336 (10%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNE-----HMTEDMFCDEFHLVDLRVM 82 +++ +TG G+I SH +L GH VI D N + E + V+ + Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 Query: 83 ENCLKVTEGVDH----VFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRF 138 L DH V + A +Q NN + +I A R +K F Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEY-YDNNVNGTLRLISAMRAANVKNF 119 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPA-EPQDAYGLEKLATEELCKHYNKDF-GIEC 196 ++SSA +Y + N + +++P PQ YG KL E++ K Sbjct: 120 IFSSSATVYGD-------NPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSI 172 Query: 197 RIGRFHNIYG--PFGTWKGGREKAP----AAFCRKAQTSTDRFEMWG------DGLQTRS 244 + R+ N G P G + P + A D ++G DG R Sbjct: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 Query: 245 FTFIDECVEG-VLRLTKSDFR---EPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 300 + + + +G V+ + K + N+G+ S+ ++ K + H P Sbjct: 233 YIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRR 292 Query: 301 EG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFW 335 EG + +D + +L W L E + T+ W Sbjct: 293 EGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 >2Q1T-A nrPDB Length = 377 Score = 235 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 128/335 (38%), Gaps = 29/335 (8%) Query: 27 NLKISITGAGGFIASHIARRLKHEG-HYVIASDWKKNEH--MTEDMFCDEFHLVDLRVME 83 N + + G GF+ S++ +RL G + V D + D F + Sbjct: 32 NTNVMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSAEKINVPDHPAVRFSETSITDDA 91 Query: 84 NCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA-RINGIKRFFYAS 142 + + D+VF+LA G I + NNT+ + + E +K+ Y++ Sbjct: 92 LLASLQDEYDYVFHLATYHGNQSSIHDPLAD-HENNTLTTLKLYERLKHFKRLKKVVYSA 150 Query: 143 SAC-----IYPEFKQLETTN-VSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 + C + + K E T+ VSL +D Y + K+ E +Y+K + Sbjct: 151 AGCSIAEKTFDDAKATEETDIVSLHNND-------SPYSMSKIFGEFYSVYYHKQHQLPT 203 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTD--------RFEMWGDGLQTRSFTFI 248 RF N+YGP GR + A + T T + G+ TR F F+ Sbjct: 204 VRARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPLENGGVATRDFIFV 263 Query: 249 DECVEGVLRLTKSDF-REPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP--EGVRG 305 ++ G++ NI S + S+ ++A + + +P + Sbjct: 264 EDVANGLIACAADGTPGGVYNIASGKETSIADLATKINEITGNNTELDRLPKRPWDNSGK 323 Query: 306 RNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQI 340 R + +LG++ ++ + +GLR T W K + Sbjct: 324 RFGSPEKARRELGFSADVSIDDGLRKTIEWTKANL 358 >4WOK-A nrPDB Length = 336 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 117/327 (35%), Gaps = 28/327 (8%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 + + G GFI SH A+ L +G+ + D H + + D F D+ ++ Sbjct: 13 NVLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRWGD-FVEGDILDQARLVET 71 Query: 89 TEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 E V + AA +G + + NN + ++++A R+ + ++SS Sbjct: 72 MEKYAPVAVIHFAA-SAYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQNVIFSSSCAT 130 Query: 147 YPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYG 206 Y +L + P + YG KL E + Y +G+ R+ N G Sbjct: 131 YGVPSRLPI-------GEGEAQNPINPYGRTKLIAEHMLADYAVAYGLRYVALRYFNASG 183 Query: 207 PFGTWKGGREKAPAAFC-----RKAQTSTDRFEMWGDGLQT------RSFTFIDECVE-- 253 + G + P A D E++GD +T R + + + Sbjct: 184 ADIDGELGEKHDPETHLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYIHVTDLARAH 243 Query: 254 --GVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGV-RGRNSDN 310 V L ++ VN+G+ S+ E+ + + + +P+ G +D Sbjct: 244 VLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPVAMRARRAGDPPALYADP 303 Query: 311 NLIKEKLGWAPNMR-LKEGLRITYFWI 336 L EKLG+ L +R Sbjct: 304 ALAAEKLGFHTVYSDLDTIIRTAAPHF 330 >3M2P-A nrPDB Length = 311 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 131/308 (42%), Gaps = 24/308 (7%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 +LKI++TG GF+ ++ +K++G+ I D E+ + D +E+ + Sbjct: 2 SLKIAVTGGTGFLGQYVVESIKNDGNTPIILTRSIGNKAINDY---EYRVSDY-TLEDLI 57 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 VD V +LAA G G I ++N +++ N+ +A N I YAS+ Sbjct: 58 NQLNDVDAVVHLAATRGSQGKISE-----FHDNEILTQNLYDACYENNISNIVYASTISA 112 Query: 147 YPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYG 206 Y + SL ++ P YG+ KLA E + Y++ G+ + RF ++YG Sbjct: 113 YSD-------ETSLPWNEKELPLPDLMYGVSKLACEHIGNIYSRKKGLCIKNLRFAHLYG 165 Query: 207 PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVL-RLTKSDFRE 265 + F R+A ++ + + + R F + + + V+ L + Sbjct: 166 ----FNEKNNYMINRFFRQA-FHGEQLTLHANSVAKREFLYAKDAAKSVIYALKQEKVSG 220 Query: 266 PVNIGSDEMVSMNEMAEMV-LSFEEK-KLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNM 323 NIGS + ++ E+A + +F K L + + EG+ D++ KE L ++ + Sbjct: 221 TFNIGSGDALTNYEVANTINNAFGNKDNLLVKNPNANEGIHSSYMDSSKAKELLDFSTDY 280 Query: 324 RLKEGLRI 331 + Sbjct: 281 NFATAVEE 288 >3RUE-A nrPDB Length = 351 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 79/336 (23%), Positives = 137/336 (40%), Gaps = 37/336 (11%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHM-----------TEDMFCDEFHLVDL 79 ITG GFI S++ +L VI D H TE F D+ Sbjct: 29 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWSRFCFIEGDI 88 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 R + C +V +GVDHV + AA +G + + N N++ AA+ ++ F Sbjct: 89 RDLTTCEQVMKGVDHVLHQAA-LGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQSFT 147 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 YA+S+ Y + L + + P Y + K E + Y + +G + Sbjct: 148 YAASSSTYGDHPA-------LPKVEENIGNPLSPYAVTKYVNEIYAQVYARTYGFKTIGL 200 Query: 200 RFHNIYG----PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV 255 R+ N++G P G + K AA + D + GDG +R F +ID ++ Sbjct: 201 RYFNVFGRRQDPNGAYAAVIPKWTAAMLK-----GDDVYINGDGETSRDFCYIDNVIQMN 255 Query: 256 L--RLTKSDFRE-PVNIGSDEMVSMNEMAEMVLSFEE-----KKLPIHHIPGPEG-VRGR 306 + L K ++ N+ + ++NE++ + KL I + G VR Sbjct: 256 ILSALAKDSAKDNIYNVAVGDRTTLNELSGYIYDELNLIHHIDKLSIKYREFRSGDVRHS 315 Query: 307 NSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEK 342 +D + L + PN++++EGLR++ W ++ Sbjct: 316 QADVTKAIDLLKYRPNIKIREGLRLSMPWYVRFLKG 351 >1EQ2-A nrPDB Length = 310 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 126/321 (39%), Gaps = 30/321 (9%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVI-ASDWKKNEHMTEDMFCDEFHLVDLRVMENCL-- 86 I +TG GFI S+I + L +G I D K+ T+ + + ++ D E+ L Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDG--TKFVNLVDLNIADYMDKEDFLIQ 59 Query: 87 ----KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 + V+ +F+ A + + +M NN S ++ I F YAS Sbjct: 60 IMAGEEFGDVEAIFHEGACS---STTEWDGKYMMDNNYQYSKELLHYCLEREIP-FLYAS 115 Query: 143 SACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFH 202 SA Y ES + +P + YG K +E + + + R+ Sbjct: 116 SAATYG------GRTSDFIESREYE-KPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYF 168 Query: 203 NIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQ--TRSFTFIDECVEGVLRLTK 260 N+YGP KG A AF Q + +G + R F ++ + + L + Sbjct: 169 NVYGPREGHKG--SMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADVNLWFLE 226 Query: 261 SDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRN-----SDNNLIKE 315 + N+G+ S +A+ L++ KK I +IP P+ ++GR +D ++ Sbjct: 227 NGVSGIFNLGTGRAESFQAVADATLAY-HKKGQIEYIPFPDKLKGRYQAFTQADLTNLRA 285 Query: 316 KLGWAPNMRLKEGLRITYFWI 336 P + EG+ W+ Sbjct: 286 AGYDKPFKTVAEGVTEYMAWL 306 >4EJ0-A nrPDB Length = 342 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 70/346 (20%), Positives = 134/346 (38%), Gaps = 49/346 (14%) Query: 28 LKISITGAGGFIASHIARRLKHEGHY-VIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 + + +TGA GFI +++ + L G +IA D + + + D + Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVDNL--TRADKFKNLVDCEIDDYLDKTEFV 70 Query: 87 KVTEGVD-----HVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYA 141 + D VF+ A M +++ +M NN S +++A G + F YA Sbjct: 71 ERFARGDFGKVRAVFHEGACSDTM---ETDGRYMMDNNFRYSRAVLDACLAQGAQ-FLYA 126 Query: 142 SSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 SSA IY + + P + YG K +++ + + R+ Sbjct: 127 SSAAIYGGSSRFV--------EEREVEAPLNVYGYSKFLFDQVIRRVMPGAKSQIAGFRY 178 Query: 202 HNIYGPFGTWKGGREKAPAAFCRKAQTSTD-------RFEMWGDGLQTRSFTFIDECVEG 254 N+YGP + KG A AF Q + + +G G QTR F +++ + Sbjct: 179 FNVYGPRESHKG--RMASVAFHNFNQFRAEGKVKLFGEYSGYGPGEQTRDFVSVEDVAKV 236 Query: 255 VLR-LTKSDFREPVNIGSDEMVSMNEMAEMV--------------LSFEEKKLPIHHIPG 299 L + N+G+ N++A V L+ + ++ + ++P Sbjct: 237 NLYFFDHPEKSGIFNLGTGRAQPFNDIAATVVNTLRALEGQPALTLAEQVEQGLVEYVPF 296 Query: 300 PEGVRGRN-----SDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQI 340 P+ +RG+ +D ++ AP + ++EG+ W+ Q+ Sbjct: 297 PDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDRYVRWLFGQL 342 >2X86-A nrPDB Length = 357 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 126/321 (39%), Gaps = 30/321 (9%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVI-ASDWKKNEHMTEDMFCDEFHLVDLRVMENCL-- 86 I +TG GFI S+I + L +G I D K+ T+ + + ++ D E+ L Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDG--TKFVNLVDLNIADYMDKEDFLIQ 106 Query: 87 ----KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 + V+ +F+ A + + +M NN S ++ I F YAS Sbjct: 107 IMAGEEFGDVEAIFHEGACS---STTEWDGKYMMDNNYQYSKELLHYCLEREIP-FLYAS 162 Query: 143 SACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFH 202 SA Y ES + +P + +G K +E + + + R+ Sbjct: 163 SAATYG------GRTSDFIESREYE-KPLNVFGYSKFLFDEYVRQILPEANSQIVGFRYF 215 Query: 203 NIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQ--TRSFTFIDECVEGVLRLTK 260 N+YGP KG A AF Q + +G + R F ++ + + L + Sbjct: 216 NVYGPREGHKG--SMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADVNLWFLE 273 Query: 261 SDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRN-----SDNNLIKE 315 + N+G+ S +A+ L++ KK I +IP P+ ++GR +D ++ Sbjct: 274 NGVSGIFNLGTGRAESFQAVADATLAY-HKKGQIEYIPFPDKLKGRYQAFTQADLTNLRA 332 Query: 316 KLGWAPNMRLKEGLRITYFWI 336 P + EG+ W+ Sbjct: 333 AGYDKPFKTVAEGVTEYMAWL 353 >4WKG-A nrPDB Length = 660 Score = 211 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 68/350 (19%), Positives = 133/350 (38%), Gaps = 47/350 (13%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV--DLRVMENC 85 ++ I G GFI +H+ RL E HY + ++ ++ + FH V D+ + Sbjct: 316 TRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEW 375 Query: 86 LKV-TEGVDHVFNLAADMGGMGFIQSNHSV----IMYNNTMISFNMIEAARINGIKRFFY 140 ++ + D V L A + + ++ V N +I + + KR + Sbjct: 376 IEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCV------KYRKRIIF 429 Query: 141 ASSACIYP----EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 S++ +Y ++ + +N+ + + +P+ Y + K + + Y + G++ Sbjct: 430 PSTSEVYGMCSDKYFDEDHSNLIVGPVN----KPRWIYSVSKQLLDRVIWAYGEKEGLQF 485 Query: 197 RIGRFHNIYGPF----GTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECV 252 + R N GP + G +A ++ G Q R FT I + + Sbjct: 486 TLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLV-EGSPIKLIDGGKQKRCFTDIRDGI 544 Query: 253 EGVLRLTKSDF----REPVNIGSD-EMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVR--- 304 E + R+ ++ E +NIG+ S+ E+ EM+L+ EK HH P G R Sbjct: 545 EALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVE 604 Query: 305 -------------GRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIE 341 R L W P + ++E + T + ++ Sbjct: 605 SSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVD 654 >1Z45-A nrPDB Length = 699 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 60/352 (17%), Positives = 121/352 (34%), Gaps = 36/352 (10%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMF-------CDEFHLVDLRVM 82 + +TG G+I SH L G+ + +D N F+ VDL Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 Query: 83 ENCLKVTE--GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFY 140 + KV + +D V + A Q +NN + + ++E + + +F + Sbjct: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRY-YHNNILGTVVLLELMQQYNVSKFVF 132 Query: 141 ASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNK--DFGIECRI 198 +SSA +Y + + + + P P + YG K A E + + I Sbjct: 133 SSSATVYGDATRFPNM---IPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAI 189 Query: 199 GRFHNIYGPFGTWKGGREK------APAAFCRKAQTSTDRFEMWG------DGLQTRSFT 246 R+ N G + G + + A ++ ++G DG R + Sbjct: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249 Query: 247 FIDE----CVEGVLRLTKSDFREP----VNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIP 298 + + + + L + E N+GS + ++ E+ LP Sbjct: 250 HVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTG 309 Query: 299 GPEGVRGRN-SDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSD 349 G + + K +L W +++++ + + W E + +G + Sbjct: 310 RRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGVE 361 >1I3M-A nrPDB Length = 348 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 120/344 (34%), Gaps = 40/344 (11%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDW-----KKNEHMTEDM--------FCDEFH 75 K+ +TG G+I SH L G+ + D + + E + EF Sbjct: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 Query: 76 LVDLRVMENCLKVTEGVD--HVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARIN 133 +D+ ++ + V + A +Q N T + ++E + + Sbjct: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLT-GTIQLLEIMKAH 122 Query: 134 GIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHY-NKDF 192 G+K ++SSA +Y + L + YG K EE+ + D Sbjct: 123 GVKNLVFSSSATVYGNPQYLPLDEAHPTGGCT------NPYGKSKFFIEEMIRDLCQADK 176 Query: 193 GIECRIGRFHNIYGPFGTWKGGREK------APAAFCRKAQTSTDRFEMWG------DGL 240 + R+ N G + G + + A + ++G DG Sbjct: 177 TWNVVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGT 236 Query: 241 QTRSFTFIDE----CVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHH 296 R + + + + + +L + N+G+ S+ +M + + KK+P Sbjct: 237 GVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKV 296 Query: 297 IPGPEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQ 339 + EG V ++ +L +E+LGW + L + W K+ Sbjct: 297 VARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQN 340 >6AQY-A nrPDB Length = 341 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 121/333 (36%), Gaps = 37/333 (11%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 I +TG G + I + D DLR + C + Sbjct: 27 ILVTGGTGLFGKAVEH---------IVKKEQIKGKWVFLGSKD----GDLRDADACKQPF 73 Query: 90 EGV--DHVFNLAADMGGMGFIQSNHSVIMY-NNTMISFNMIEAARINGIKRFFYASSACI 146 E +V +LAA +GG+ F N V + +N ++ N++ G+K+ S C+ Sbjct: 74 EKYRPTYVIHLAAFVGGL-FKNMNFKVSFWLDNVNMNNNILTCCYDFGVKKTISCLSTCV 132 Query: 147 YPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF----- 201 +P+ + T L E P +AY K + L + YN+ E + F Sbjct: 133 FPDKIEYPITEEKLHEGP--PHFSNNAYAYAKRMLDMLGRWYNEKAVNEGKSCLFTSVIP 190 Query: 202 HNIYGPFGTWK---GGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLR- 257 N++GP + G C KAQ + F ++G G R F + + +L Sbjct: 191 TNLFGPHDNFNVEAGHVLPGLMHKCYKAQQNGTDFVVFGSGKPLRQFLYSHDAARMLLWT 250 Query: 258 LTKSDFREPVN--IGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNSDNNLIK 314 + EP+ + ++ S+ ++A+ + +F + +G + S N Sbjct: 251 MFNYQSEEPIMLCVSEEDEKSIGQVAQTIKDAFNFTGNMVFDTSKADGQYKKTSSNAKFL 310 Query: 315 EK---LGWAPNMRLKEGLRITYFWIKEQIEKEK 344 + P ++ ++ T W E E + Sbjct: 311 RLNPTFQYTP---FEQAIKETVQWFLENYETAR 340 >4LIS-A nrPDB Length = 371 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 61/359 (16%), Positives = 116/359 (32%), Gaps = 46/359 (12%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHM----------TEDMFCDEFHLVDL 79 + +TG G+I S L G+ V+ +D N + + + D Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTDE 65 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 + + +D V + AA + +G + N + ++ + + + Sbjct: 66 AAFDKVFEAHPDIDSVIHFAA-LKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTNIV 124 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHY-------NKDF 192 ++SSA +Y + + + + P P + YG K A E K Sbjct: 125 FSSSATVYGDATRFPDM---IPIPEHCPLGPTNPYGNTKFAIELAITDVINAQRNNAKKA 181 Query: 193 GIEC-------RIGRFHNIYG--PFGTWKGGREKAP----AAFCRKAQTSTDRFEMWG-- 237 G E + R+ N G P G + P + A ++ ++G Sbjct: 182 GNETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDD 241 Query: 238 ----DGLQTRSFTFIDECVEG-VLRLTKSDFREP----VNIGSDEMVSMNEMAEMVLSFE 288 DG R + I + +G + L P N+G+ ++ EM Sbjct: 242 YASHDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIRAFSKAV 301 Query: 289 EKKLPIHHIPGPEGVRGRN-SDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAK 346 + LP P G S+ +LGW L++ + W K + + + Sbjct: 302 GRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGYRQQ 360 >1GY8-A nrPDB Length = 397 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 61/372 (16%), Positives = 122/372 (32%), Gaps = 66/372 (17%) Query: 27 NLKISITGAGGFIASHIARRLKHE-GHYVIASDWKKNEHMTEDMF--------------- 70 ++++ + G G+I SH R L + H V+ D H D Sbjct: 2 HMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDG 61 Query: 71 -----CDEF---HLVDLRVMENCLKVTEG---VDHVFNLAADMGGMGFIQSNHSVIMYNN 119 D + + D+R + V +D V ++ A + ++ + NN Sbjct: 62 PKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVR-DPLKYYDNN 120 Query: 120 TMISFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKL 179 + +++A ++ + ++SSA I+ + + P+ YG KL Sbjct: 121 VVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKL 180 Query: 180 ATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTST--------- 230 E + + + +GI+ R+ N G G + Sbjct: 181 IAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQ 240 Query: 231 -----------DRFEMWG------DGLQTRSFTFIDECVEG-VLRL---------TKSDF 263 R ++G DG R + + + +L L KS + Sbjct: 241 RLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKY 300 Query: 264 REPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGR-NSDNNLIKEKLGWAPN 322 N+G+ S+ E+ E+ +P+ EG + ++ +E LGW P Sbjct: 301 FSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPK 360 Query: 323 M-RLKEGLRITY 333 L+ + ++ Sbjct: 361 YDTLEAIMETSW 372 >3ENK-A nrPDB Length = 341 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 114/338 (33%), Gaps = 35/338 (10%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-------FHLVDLRV 81 I +TG G+I SH A L G+ V+ +D N ++ FH D+ Sbjct: 7 TILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSD 66 Query: 82 MENCLKVTEG--VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 ++ + + + AA + NN +++ R +KR Sbjct: 67 ERALARIFDAHPITAAIHFAALKAVGESVAKPIEY-YRNNLDSLLSLLRVMRERAVKRIV 125 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHY-NKDFGIECRI 198 ++SSA +Y ++ + +P + YG KL E++ + D Sbjct: 126 FSSSATVYGVPERSPI-------DETFPLSATNPYGQTKLMAEQILRDVEAADPSWRVAT 178 Query: 199 GRFHNIYGPFGTWKGGREKA------PAAFCRKAQTSTDRFEMWG------DGLQTRSFT 246 R+ N G + G + A + A ++ ++G DG R + Sbjct: 179 LRYFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVRDYI 238 Query: 247 FIDE----CVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEG 302 + + + + L + D VN+G+ S+ E+ + +P + G Sbjct: 239 HVVDLARGHIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVARRPG 298 Query: 303 VRGR-NSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQ 339 ++ E +GW L+ + W + Sbjct: 299 DVAECYANPAAAAETIGWKAERDLERMCADHWRWQENN 336 >2PK3-A nrPDB Length = 321 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 118/318 (37%), Gaps = 13/318 (4%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 +++ ITG GF+ ++A L + + + + NE ++ ++D + ++ + Sbjct: 12 SMRALITGVAGFVGKYLANHLTEQ-NVEVFGTSRNNEAKLPNVEMISLDIMDSQRVKKVI 70 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGI-KRFFYASSAC 145 D++F+LAA N N + ++++A R + + R S+ Sbjct: 71 SDI-KPDYIFHLAAKSSVKDSW-LNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTIGSSE 128 Query: 146 IYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIY 205 Y E+ + P YG+ K + L + Y K +G++ R N Sbjct: 129 EYGMILPEESPVS-----EENQLRPMSPYGVSKASVGMLARQYVKAYGMDIIHTRTFNHI 183 Query: 206 GPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTK-SDFR 264 GP + + + G+ R FT + + V+ L++ Sbjct: 184 GPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLSQYGKTG 243 Query: 265 EPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIP---GPEGVRGRNSDNNLIKEKLGWAP 321 + N+ S + ++ +++L+ K+ P P V N +K+ GW P Sbjct: 244 DVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEVPTLIGSNKRLKDSTGWKP 303 Query: 322 NMRLKEGLRITYFWIKEQ 339 + L++ L ++ Sbjct: 304 RIPLEKSLFEILQSYRQA 321 >4BKP-A nrPDB Length = 336 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 60/328 (18%), Positives = 121/328 (36%), Gaps = 22/328 (6%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENC 85 ++++I +TG G + I + + +D ED DL Sbjct: 21 QSMRILVTGGSGLVGKAIQK---------VVADGAGLP--GEDWVFVSSKDADLTDTAQT 69 Query: 86 LKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASS 143 + E V HV +LAA +GG+ + N ++ N++ +A G ++ S Sbjct: 70 RALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARKVVSCLS 129 Query: 144 ACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHN 203 CI+P+ + P Y K + + Y + +G N Sbjct: 130 TCIFPDKTTYPIDETMIHNGP--PHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVIPTN 187 Query: 204 IYGPFGTWKGGREKAPAAFCRK---AQTSTDRFEMWGDGLQTRSFTFIDECVE-GVLRLT 259 ++GP + K A++S +WG G R F + + + + L Sbjct: 188 VFGPHDNFNIEDGHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLR 247 Query: 260 KSDFREPV--NIGSDEMVSMNEMAEMVLSFEEKKLPIHH-IPGPEGVRGRNSDNNLIKEK 316 + + EP+ ++G ++ VS+ E AE V+ + + +G + + N+ ++ Sbjct: 248 EYNEVEPIILSVGEEDEVSIKEAAEAVVEAMDFHGEVTFDTTKSDGQFKKTASNSKLRTY 307 Query: 317 LGWAPNMRLKEGLRITYFWIKEQIEKEK 344 L K+ ++ T W + E+ + Sbjct: 308 LPDFRFTPFKQAVKETCAWFTDNYEQAR 335 >2PZM-A nrPDB Length = 330 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 107/320 (33%), Gaps = 36/320 (11%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHM-----TEDMFCDEFHLVDLRV 81 +++I ITG G + S++ +GH ++ D + E + D + Sbjct: 20 HMRILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGLSVIEGSVTDAGL 79 Query: 82 MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYA 141 +E HV + AA + + N S N+ +AA G+KR Sbjct: 80 LERAFDSF-KPTHVVHSAAAY----KDPDDWAEDAATNVQGSINVAKAASKAGVKRLLNF 134 Query: 142 SSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 +A Y + S P P +YG+ K A E + R Sbjct: 135 QTALCYGRPATVPIPIDS-------PTAPFTSYGISKTAGEAFLMM----SDVPVVSLRL 183 Query: 202 HNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDE-CVEGVLRLTK 260 N+ GP F ++ + F R F + + L L + Sbjct: 184 ANVTGPRLAIGP-----IPTFYKRLKAGQKCFC----SDTVRDFLDMSDFLAIADLSLQE 234 Query: 261 SDFREPVNIGSDEMVSMNEMAEMVLSFEE----KKLPIHHIPGPEGVRGRNSDNNLIKEK 316 N+ + E S+ E+ ++VL + + +P+ PG + V D + + + Sbjct: 235 GRPTGVFNVSTGEGHSIKEVFDVVLDYVGATLAEPVPV-VAPGADDVPSVVLDPSKTETE 293 Query: 317 LGWAPNMRLKEGLRITYFWI 336 GW + K+ + W Sbjct: 294 FGWKAKVDFKDTITGQLAWY 313 >3RFT-A nrPDB Length = 267 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 20/183 (10%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 ++ +TGA G + + RL + +D + + C + L D + + Sbjct: 5 RLLVTGAAGQLGRVMRERLAPMAEILRLADLSPLDPAGPNEECVQCDLADANAVNAMV-- 62 Query: 89 TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYP 148 G D + +L ++ I+ N + +N+ EAAR +G R +ASS Sbjct: 63 -AGCDGIVHLGGI-----SVEKPFEQILQGNIIGLYNLYEAARAHGQPRIVFASSNHTIG 116 Query: 149 EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF------H 202 + Q E + PA P YG+ K E L + Y FG E + R Sbjct: 117 YYPQTERLGPDV------PARPDGLYGVSKCFGENLARMYFDKFGQETALVRIGSCTPEP 170 Query: 203 NIY 205 N Y Sbjct: 171 NNY 173 >1DB3-A nrPDB Length = 372 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 76/377 (20%), Positives = 126/377 (33%), Gaps = 60/377 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFC-----------DEFHLVDL 79 ITG G S++A L +G+ V + + TE + H DL Sbjct: 5 LITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHYGDL 64 Query: 80 RVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK- 136 N ++ V D V+NL A +S + M + ++EA R G++ Sbjct: 65 SDTSNLTRILREVQPDEVYNLGAMSHVAVSFES-PEYTADVDAMGTLRLLEAIRFLGLEK 123 Query: 137 --RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI 194 RF+ AS++ +Y + + + P P+ Y + KL + +Y + +G+ Sbjct: 124 KTRFYQASTSELYG-------LVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGM 176 Query: 195 ECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEG 254 G N P K A AQ + G+ R + + V+ Sbjct: 177 YACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCLYL-GNMDSLRDWGHAKDYVKM 235 Query: 255 VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPI----------------HHIP 298 + + + E I + S+ + EM + KL H P Sbjct: 236 QWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEGTGVEEKGIVVSVTGHDAP 295 Query: 299 ----------------GPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEK 342 P V D EKLGW P + L+E + E +K Sbjct: 296 GVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEMVANDLEAAKK 355 Query: 343 E---KAKGSDVSLYGSS 356 K+ G DV++ S Sbjct: 356 HSLLKSHGYDVAIALES 372 >3WMX-A nrPDB Length = 358 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 65/330 (19%), Positives = 123/330 (37%), Gaps = 28/330 (8%) Query: 29 KISITGAGGFIASHIARRL--KHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 KI I GA G I S +A L ++ VI SD + + + D + + Sbjct: 27 KILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHVH-LTHEMLNATDRGELATVV 85 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISF-NMIEAARINGIKRFFYASSAC 145 + G+ V+ LAA + G + +N M S N++E AR G++R F+ SS Sbjct: 86 ER-HGITQVYLLAAALSATGEKAPQWA---WNLNMTSLLNVLELARQTGLERVFWPSSIA 141 Query: 146 IYP-EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNI 204 + +T ++ E P YG+ K A E C+ Y+ + G++ R R+ + Sbjct: 142 AFGPTTPAGQTPQKTVME-------PTTVYGISKQAGEGWCRWYHANHGVDVRSVRYPGL 194 Query: 205 YGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKS--- 261 GG A T + + + + ++ + + + L ++ Sbjct: 195 ISHKTPPGGGTTDYAVDIFHAAVT-GEPYTCFLKEDEALPMMYMPDAIRATIELMEAPAD 253 Query: 262 --DFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPG-PEGVRGRNSDN---NLIKE 315 R NI + ++A + + I + P + + D+ ++ + Sbjct: 254 KLSERGSYNIA-GMSFTPAQIAAAI-REQVPGFQIRYEPDYRQAIAQGWPDSIDDSVARA 311 Query: 316 KLGWAPNMRLKEGLRITYFWIKEQIEKEKA 345 GW LKE + +K + + A Sbjct: 312 DWGWKAQYGLKEMVADMLANLKATLAGDPA 341 >2Q1W-A nrPDB Length = 333 Score = 131 bits (328), Expect = 6e-31, Method: Composition-based stats. Identities = 60/319 (18%), Positives = 106/319 (33%), Gaps = 33/319 (10%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNE-----HMTEDMFCDEFHLVDLRVME 83 K+ ITG G I SHIA L G V+ D ++ E + D ++ Sbjct: 23 KVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRREHLKDHPNLTFVEGSIADHALVN 82 Query: 84 NCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASS 143 + + D V + AA + N + N+++AA+ N + RF Y + Sbjct: 83 QLIGDLQP-DAVVHTAASY----KDPDDWYNDTLTNCVGGSNVVQAAKKNNVGRFVYFQT 137 Query: 144 ACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHN 203 A Y + + + A +Y + K A E Y + G++ R N Sbjct: 138 ALCYGVKPIQQPVRLDHPRNPA-----NSSYAISKSANE----DYLEYSGLDFVTFRLAN 188 Query: 204 IYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDF 263 + GP F ++ F R F F+ + +R Sbjct: 189 VVGPRNVSGP-----LPIFFQRLSEGKKCFVT----KARRDFVFVKDLARATVRAVDGVG 239 Query: 264 REPVNIGSDEMVSMNEMAEMVLSF----EEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGW 319 + S V++ E+ + V+ + I + GP+ D + + G Sbjct: 240 HGAYHFSSGTDVAIKELYDAVVEAMALPSYPEPEIREL-GPDDAPSILLDPSRTIQDFGK 298 Query: 320 APNMRLKEGLRITYFWIKE 338 LKE + + +E Sbjct: 299 IEFTPLKETVAAAVAYFRE 317 >1N7G-A nrPDB Length = 381 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 119/339 (35%), Gaps = 36/339 (10%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCD------------EFHLVD 78 ITG G S++ L +G+ V + + T+ + + H D Sbjct: 32 LITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQRINHIYIDPHNVNKALMKLHYAD 91 Query: 79 LRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 L + + + + D V+NLAA + + ++EA R + I Sbjct: 92 LTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFE-IPDYTADVVATGALRLLEAVRSHTID 150 Query: 137 -----RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 +++ A S+ ++ +S+ P P+ Y K A +Y + Sbjct: 151 SGRTVKYYQAGSSEMFGSTP--------PPQSETTPFHPRSPYAASKCAAHWYTVNYREA 202 Query: 192 FGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDEC 251 +G+ G N P K A R + + G+ +R + F + Sbjct: 203 YGLFACNGILFNHESPRRGENFVTRKITRALGRIKVGLQTKLFL-GNLQASRDWGFAGDY 261 Query: 252 VEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIP------GPEGVRG 305 VE + + + + + + ++E ++ E ++ + ++ P V Sbjct: 262 VEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWK-DYVEIDQRYFRPAEVDN 320 Query: 306 RNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEK 344 D + KE LGW P + ++ +++ E ++EK Sbjct: 321 LQGDASKAKEVLGWKPQVGFEKLVKMMVDEDLELAKREK 359 >2Z95-A nrPDB Length = 345 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 57/337 (16%), Positives = 118/337 (35%), Gaps = 40/337 (11%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDM------FCDEFHLVDLRVM 82 + ITG G +++A+ L +G+ V +D + E + + + +DL Sbjct: 5 RALITGIRGQDGAYLAKLLLEKGYEVYGADRRSGEFASWRLKELGIENDVKIIHMDLLEF 64 Query: 83 ENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR-INGIKRFF 139 N ++ E V D V+NLAA + + + + ++EA R + +F+ Sbjct: 65 SNIIRTIEKVQPDEVYNLAAQSFVGVSFE-QPILTAEVDAIGVLRILEALRTVKPDTKFY 123 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 AS++ ++ + ++ + +++ P P+ Y + KL + +Y + + + G Sbjct: 124 QASTSEMFGKVQE-------IPQTEKTPFYPRSPYAVAKLFGHWITVNYREAYNMFACSG 176 Query: 200 RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLT 259 N P + K + R D+ + G+ R + + E VE + + Sbjct: 177 ILFNHESPLRGIEFVTRKITYSLARIKYGLQDKLVL-GNLNAKRDWGYAPEYVEAMWLMM 235 Query: 260 KSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPI----------------------HHI 297 + + I + E ++ E E + Sbjct: 236 QQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEWVGEGINEKGIDRNTGKVIVEVSEEF 295 Query: 298 PGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYF 334 P V + +KLGW P E + I Sbjct: 296 FRPAEVDILVGNPEKAMKKLGWKPRTTFDELVEIMME 332 >5UZH-A nrPDB Length = 345 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 111/342 (32%), Gaps = 47/342 (13%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFC-----------DEFHLVDL 79 ITG G S++A L +G+ V + + T + + DL Sbjct: 5 LITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLLYGDL 64 Query: 80 RVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKR 137 N + + + D ++NLAA + + + + ++EA R G+++ Sbjct: 65 TDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEM-PEYTANVDGIGTLRLLEAIRACGLEK 123 Query: 138 ---FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI 194 F+ AS++ +Y + + + P P+ Y KL + + +Y + + + Sbjct: 124 KTKFYQASTSELYG-------LVQEVPQKETTPFYPRSPYACAKLYSYWIVVNYREAYNM 176 Query: 195 ECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEG 254 G N K A R D + G+ R + + VE Sbjct: 177 FALNGILFNHESIRRGPTFVTRKITMAVARIKLGLQDCLYL-GNLDAERDWGHAKDYVEA 235 Query: 255 VLRLTKSDFREPVNIGSDEMVSMNE--------MAEMVLSFEEKKLPIHHIP-------- 298 + + + + + + E S+ E + + V E+ H Sbjct: 236 MWLMLQQEQPRDFCVATGEKHSVREFVEKAFACIGQTVEWKGERGTVEEHGVVDGVVRVR 295 Query: 299 ------GPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYF 334 P V D L + LGW + +E +R Sbjct: 296 VDPRYFRPTEVDQLLGDPTLAETVLGWKRKVSFEELVRGMVE 337 >6GPK-A nrPDB Length = 373 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 57/352 (16%), Positives = 117/352 (33%), Gaps = 48/352 (13%) Query: 22 YWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKN------------EHMTEDM 69 Y+ S ITG G S++A L +G+ V + + Sbjct: 19 YFQSMRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIE 78 Query: 70 FCDEFHLVDLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMI 127 + H DL +K+ V ++NL A + + + ++ Sbjct: 79 GNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLA-EYTADVDGVGTLRLL 137 Query: 128 EAARINGI---KRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEEL 184 +A + G+ +F+ AS++ +Y + ++ + + + P P+ YG KL + Sbjct: 138 DAVKTCGLINSVKFYQASTSQLYGKVQE-------IPQKETTPFYPRSPYGAAKLYAYWI 190 Query: 185 CKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRS 244 ++ + + + G N P K + + + F + G+ R Sbjct: 191 VVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL-GNLDAKRD 249 Query: 245 FTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAE--------MVLSFEEKKLPIHH 296 + + VE + + ++D E I + E+ S+ E E ++ + + + Sbjct: 250 WGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGR 309 Query: 297 IP--------------GPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYF 334 P V D K+KL W P + E +R Sbjct: 310 CKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 361 >1RPN-A nrPDB Length = 335 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 113/320 (35%), Gaps = 27/320 (8%) Query: 31 SITGAGGFIASHIARRLKHEGHYV--IASDWKKNEHMTEDMFCDEFHL----VDLRVMEN 84 +TG G +++A+ L +G+ V + + + E + D+ + Sbjct: 18 LVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGDIQYEDGDMADACS 77 Query: 85 CLKVTEGVD--HVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARING-IKRFFYA 141 + V+NLAA + + + ++ ++EA R RF+ A Sbjct: 78 VQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTH-LLEAIRQFSPETRFYQA 136 Query: 142 SSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 S++ ++ + ++ + P P+ YG+ KL + +Y + FG+ G Sbjct: 137 STSEMFGLIQAE-------RQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHASSGIL 189 Query: 202 HNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKS 261 N P + K A R + G+ R + F + VE + + + Sbjct: 190 FNHESPLRGIEFVTRKVTDAVARIKLGKQQELRL-GNVDAKRDWGFAGDYVEAMWLMLQQ 248 Query: 262 DFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPG-------PEGVRGRNSDNNLIK 314 D + + + ++ +M ++ +FE L P V + + Sbjct: 249 DKADDYVVATGVTTTVRDMCQI--AFEHVGLDYRDFLKIDPAFFRPAEVDVLLGNPAKAQ 306 Query: 315 EKLGWAPNMRLKEGLRITYF 334 LGW P L E +R+ Sbjct: 307 RVLGWKPRTSLDELIRMMVE 326 >2NNL-D nrPDB Length = 337 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 113/336 (33%), Gaps = 28/336 (8%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHYVIAS----DWKKNEHMTEDMFCDEFHL---- 76 S++ + +TGA GFI S + RL G+ V A+ K D+ E HL Sbjct: 3 SQSETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWK 62 Query: 77 VDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 DL + + +G VF++A M + VI + M A ++ Sbjct: 63 ADLADEGSFDEAIKGCTGVFHVATPMD-FESKDPENEVIKPTIEGMLGIMKSCAAAKTVR 121 Query: 137 RFFYASSACIYP----EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDF 192 R + SSA + + + S E Y + K E+ Y K+ Sbjct: 122 RLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKEN 181 Query: 193 GIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECV 252 I+ + GPF A + + + G F +D+ Sbjct: 182 NIDFITIIPTLVVGPFIMSSMPPSLITA--LSPITGNEAHYSIIRQG----QFVHLDDLC 235 Query: 253 EGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVL-SFEEKKLPIHHIPGPEGVRGRNSDNN 311 + L ++ E I S + ++A+M+ + E +P G + ++ Sbjct: 236 NAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEF-KGVDENLKSVCFSS 294 Query: 312 LIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKG 347 LG+ L++ ++ +AKG Sbjct: 295 KKLTDLGFEFKYSLEDM-------FTGAVDTCRAKG 323 >1WVG-A nrPDB Length = 359 Score = 95.6 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 56/351 (15%), Positives = 111/351 (31%), Gaps = 41/351 (11%) Query: 20 EQYWPSENLKISITGAGGFIASHIARRLKHEGHYVI-ASDWKKNEHMTEDM----FCDEF 74 + +W + ++ +TG GF S ++ L G V + ++ E Sbjct: 4 KNFW--QGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRLNDLMES 61 Query: 75 HLVDLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARI 132 H+ D+R E + VF++AA + N M + +++E + Sbjct: 62 HIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKT-YSTNVMGTVHLLETVKQ 120 Query: 133 NG-IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHY--- 188 G IK +S Y + P D Y K E + + Sbjct: 121 VGNIKAVVNITSDKCYDN------REWVWGYRENEPMGGYDPYSNSKGCAELVASAFRNS 174 Query: 189 ------NKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQT 242 + G+ R N+ G +++ R ++ + + Sbjct: 175 FFNPANYEQHGVGLASVRAGNVIG---GGDWAKDRLIPDILR--SFENNQQVIIRNPYSI 229 Query: 243 RSFTFIDECVEGVLRLTK------SDFREPVNIG--SDEMVSMNEMAEMVLSFEEKKL-- 292 R + + E + G + + + + F E N G ++ ++ + + +++ Sbjct: 230 RPWQHVLEPLSGYIVVAQRLYTEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASW 289 Query: 293 PIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKE 343 + P D + +LGW P L E L W K I E Sbjct: 290 LLDGENHPHEAHYLKLDCSKANMQLGWHPRWGLTETLSRIVKWHKAWIRGE 340 >4R1T-A nrPDB Length = 337 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 52/305 (17%), Positives = 113/305 (37%), Gaps = 26/305 (8%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS----DWKKNEHMTEDMFCDE---FHLVDLRVM 82 + +TGAGGFIAS + + L +G+ V + D KN H+ E E DL Sbjct: 13 VCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELEGAKERLTLCKADLLDY 72 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 ++ + G D VF+ A + + ++ + + N+I AA ++R + S Sbjct: 73 QSLREAINGCDGVFHTA------SPVTDDPEQMVEPAVIGTKNVINAAAEANVRRVVFTS 126 Query: 143 S-ACIYPEFKQLETTNVSLK--ESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 S +Y + + T V + ++ Y K+ E+ K+ G++ + Sbjct: 127 SIGAVYMDPNRDPETVVDETCWSDPDFCKNTKNWYCYGKMVAEQAAWEEAKEKGVDLVVI 186 Query: 200 RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLT 259 + GP + + + S + + +Q + + + + L Sbjct: 187 NPVLVQGPL--LQTTVNASVLHILKYLTGSAKT---YANSVQA--YVDVKDVALAHILLY 239 Query: 260 KSDFREPVNIGSDEMVSMNEMAEMVLSFEEK---KLPIHHIPGPEGVRGRNSDNNLIKEK 316 ++ + ++ ++ ++ E++ F + + P + S+ L Sbjct: 240 ETPEASGRYLCAESVLHRGDVVEILSKFFPEYPIPTKCSDVTKPRVKPYKFSNQKLKDLG 299 Query: 317 LGWAP 321 L + P Sbjct: 300 LEFTP 304 >2P4H-X nrPDB Length = 322 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 107/327 (32%), Gaps = 28/327 (8%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIAS---------DWKKNEHMTEDMFCDEFHLVDL 79 ++ +TG GF+ S I + L G+ V + D ++ F DL Sbjct: 3 RVCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLPGASEKLHFFNADL 62 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARI-NGIKRF 138 ++ EG +F+ A+ + + ++ + +++A +KRF Sbjct: 63 SNPDSFAAAIEGCVGIFHTASPID--FAVSEPEEIVTKRTVDGALGILKACVNSKTVKRF 120 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDA----YGLEKLATEELCKHYNKDFGI 194 Y SS + + SD Y + K E+ + + GI Sbjct: 121 IYTSSGSAVSFNGKDKDVLDESDWSDVDLLRSVKPFGWNYAVSKTLAEKAVLEFGEQNGI 180 Query: 195 ECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEG 254 + I G F K ++ G+ +D+ Sbjct: 181 DVVTLILPFIVGRFVCPKLPDS--IEKALVLVLGKKEQI-----GVTRFHMVHVDDVARA 233 Query: 255 VLRLTKSDFREP-VNIGSDEMVSMNEMAEMVLSF--EEKKLPIHHIPGPEGVRGRNSDNN 311 + L ++ N S +V + EM++++ + E + L + + +G R + + Sbjct: 234 HIYLLENSVPGGRYNC-SPFIVPIEEMSQLLSAKYPEYQILTVDELKEIKGARLPDLNTK 292 Query: 312 LIKEKLGWAPNMRLKEGLRITYFWIKE 338 + + G+ +++ KE Sbjct: 293 KLVDA-GFDFKYTIEDMFDDAIQCCKE 318 >1RKX-A nrPDB Length = 357 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 119/367 (32%), Gaps = 46/367 (12%) Query: 22 YWPSENLKISITGAGGFIASHIARRLKHEGHYVI-ASDWKKNEHMTED----MFCDEFHL 76 +W + ++ +TG GF ++ L+ G V S + + + Sbjct: 6 FW--QGKRVFVTGHTGFKGGWLSLWLQTMGATVKGYSLTAPTVPSLFETARVADGMQSEI 63 Query: 77 VDLRVMENCLKVTEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR-IN 133 D+R L+ + VF++AA N M + ++EA R + Sbjct: 64 GDIRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVET-YSTNVMGTVYLLEAIRHVG 122 Query: 134 GIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNK--- 190 G+K +S Y + + +E++A D Y K E + Y Sbjct: 123 GVKAVVNITSDKCYDNKEWIWG----YRENEAMGGY--DPYSNSKGCAELVTSSYRNSFF 176 Query: 191 ------DFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRS 244 G R N+ G ++ R + + + R Sbjct: 177 NPANYGQHGTAVATVRAGNVIG---GGDWALDRIVPDILR--AFEQSQPVIIRNPHAIRP 231 Query: 245 FTFIDECVEGVLRLTK------SDFREPVNIGSDEM--VSMNEMAEMVLSF---EEKKLP 293 + + E + G L L + +++ E N G ++ + + E ++ + Sbjct: 232 WQHVLEPLSGYLLLAQKLYTDGAEYAEGWNFGPNDADATPVKNIVEQMVKYWGEGASWQL 291 Query: 294 IHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEK---EKAKGSDV 350 + E + D + K +LGW P L L W K + + +++ Sbjct: 292 DGNAHPHEAHYLKL-DCSKAKMQLGWHPRWNLNTTLEYIVGWHKNWLSGTDMHEYSITEI 350 Query: 351 SLYGSSK 357 + Y ++K Sbjct: 351 NNYMNTK 357 >2GN9-A nrPDB Length = 344 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 87/252 (34%), Gaps = 40/252 (15%) Query: 26 ENLKISITGAGGFIASHIARRLKH----EGHYVIASDWKKNEHMTEDMFCDE--FHLVDL 79 +N I ITG G R++ + V + D K M + F + D+ Sbjct: 20 DNQTILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAMEFNDPRMRFFIGDV 79 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 R +E EGVD + AA + + N + N M + N+I A N I + Sbjct: 80 RDLERLNYALEGVDICIHAAALKH-VPIAEYNPLECIKTNIMGASNVINACLKNAISQVI 138 Query: 140 YASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI---EC 196 S+ A P + YG KL +++L N G + Sbjct: 139 ALSTDKA---------------------ANPINLYGATKLCSDKLFVSANNFKGSSQTQF 177 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVL 256 + R+ N+ G G+ F + Q + D TR + +DE V VL Sbjct: 178 SVVRYGNVVGSRGS-------VVPFFKKLVQNKASEIPIT-DIRMTRFWITLDEGVSFVL 229 Query: 257 R-LTKSDFREPV 267 + L + E Sbjct: 230 KSLKRMHGGEIF 241 >4J2O-A nrPDB Length = 363 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 101/269 (37%), Gaps = 41/269 (15%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS---DWKKNEHMTEDMFCDE--FHLVDLRVMEN 84 + ITG G + + +R I D KK + M + + F++ D+R + Sbjct: 26 LLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKKYHSAKLKFYIGDVRDYNS 85 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 144 L T GVD++++ AA + + + + + N + + N++EAA N +KR S+ Sbjct: 86 ILNATRGVDYIYH-AAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNHVKRVVCLSTD 144 Query: 145 -CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD-FGIECRIG--R 200 +Y P +A G+ K E++ +++ G++ I R Sbjct: 145 KAVY----------------------PINAMGISKAMMEKVMVAKSRNLEGLDTVICGTR 182 Query: 201 FHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTK 260 + N+ G+ F + + + TR +++ V+ VL + Sbjct: 183 YGNVMASRGS-------VIPLFVDQ-IRQGKPLTITDPNM-TRFMMTLEDAVDLVLYAFE 233 Query: 261 SDFREPVNIGSDEMVSMNEMAEMVLSFEE 289 + + ++ +AE + Sbjct: 234 HGENGDIFVQKAPAATIAVLAEALKQLLN 262 >4G5H-A nrPDB Length = 363 Score = 82.1 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 101/281 (35%), Gaps = 39/281 (13%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIAS---DWKKNEHMTEDMFCDE--FHLVDLRVMEN 84 + ITG G + + +R I D KK + + + + F++ D+R ++ Sbjct: 28 LLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDVRDSQS 87 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 144 VD+VF+ AA + + + + N + + N++++A +K+ S+ Sbjct: 88 VETAMRDVDYVFH-AAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICLSTD 146 Query: 145 CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRI---GRF 201 A P +A G+ K E++ +++ E + R+ Sbjct: 147 KA---------------------AYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRY 185 Query: 202 HNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKS 261 N+ G+ F K + + + + TR +++ VE V+ K Sbjct: 186 GNVMASRGS-------VIPLFIDK-IKAGEPLTITDPDM-TRFLMSLEDAVELVVHAFKH 236 Query: 262 DFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEG 302 + + ++ ++A +L E I I G Sbjct: 237 AETGDIMVQKAPSSTVGDLATALLELFEADNAIEIIGTRHG 277 >1VL0-A nrPDB Length = 292 Score = 81.3 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 49/284 (17%), Positives = 88/284 (30%), Gaps = 41/284 (14%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 +KI ITGA G + I ++LK + VI +D + + ++ + Sbjct: 13 MKILITGANGQLGREIQKQLKGKNVEVIPTDVQD------------LDITNVLAVNKFFN 60 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 + + V N AA + + + N + N+ AA G + S+ ++ Sbjct: 61 -EKKPNVVINCAAHTAVDK-CEEQYDLAYKINAIGPKNLAAAAYSVGAE-IVQISTDYVF 117 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 + T PQ AYG KL E K N + I R +YG Sbjct: 118 DGEAKEPITEFD-------EVNPQSAYGKTKLEGENFVKALNPKY----YIVRTAWLYGD 166 Query: 208 FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPV 267 + +T D ++ D + T T + VL++ Sbjct: 167 GNNF-------VKTMINLGKTH-DELKVVHDQVGTP--TSTVDLARVVLKVIDEKNYGTF 216 Query: 268 NIGSDEMVSMNEMAEMVLSFEEKKLPI-----HHIPGPEGVRGR 306 + + S + A + + + P P Sbjct: 217 HCTCKGICSWYDFAVEIFRLTGIDVKVTPCTTEEFPRPAKRPKY 260 >3HFS-A nrPDB Length = 338 Score = 81.0 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 59/328 (17%), Positives = 118/328 (35%), Gaps = 30/328 (9%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIA-----SDWKKNEHMTE--DMFCDEFHLVDLRVMEN 84 + G GF+AS + + L +G+ V + KK H+ E ++ + DL + Sbjct: 14 VVGGTGFVASLLVKLLLQKGYAVNTTVRDPDNQKKVSHLLELQELGDLKIFRADLTDELS 73 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA-RINGIKRFFYASS 143 G D VF++A + + + ++ N+++A R +KR SS Sbjct: 74 FEAPIAGCDFVFHVATPVHFAS--EDPENDMIKPAIQGVVNVMKACTRAKSVKRVILTSS 131 Query: 144 ACIYPEFKQLETTNVSLKESDAWPAE-------PQDAYGLEKLATEELCKHYNKDFGIEC 196 A QL+ T + + E + E P Y K E+ + ++ I+ Sbjct: 132 AAAV-TINQLDGTGLVVDEKNWTDIEFLTSAKPPTWGYPASKTLAEKAAWKFAEENNIDL 190 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWG-DGLQTRSF----TFIDEC 251 + G T A + + F + G G+Q S +++ Sbjct: 191 ITVIPTLMAGSSLTSDVPSSIGLAMSLI----TGNEFLINGMKGMQMLSGSVSIAHVEDV 246 Query: 252 VEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLS-FEEKKLPIHHIPGPEGVRGRNSDN 310 + + + + I S+ E+A+ + + + K+P P + S Sbjct: 247 CRAHIFVAEKESASGRYICCAANTSVPELAKFLSKRYPQYKVPTDFGDFPPKSKLIISSE 306 Query: 311 NLIKEKLGWAPNMRLKEGLRITYFWIKE 338 L+KE G++ ++E + + K Sbjct: 307 KLVKE--GFSFKYGIEEIYDESVEYFKA 332 >4R1U-A nrPDB Length = 349 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 56/326 (17%), Positives = 114/326 (34%), Gaps = 31/326 (9%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIAS----DWKKNEHMTEDMFCDE---FHLVDL 79 + + +TGAGGFIAS + + L G+ V + + KN H+ E E H VDL Sbjct: 27 DQTVCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEGARERLTLHKVDL 86 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF 139 +++ V G VF+ A + N ++ + N+I A+ ++R Sbjct: 87 LDLQSIQSVVHGCHGVFHTA------SPVTDNPDEMLEPAVNGTKNVIIASAEAKVRRVV 140 Query: 140 YASS-ACIYPEFKQLETTNVSLKESDAWPA--EPQDAYGLEKLATEELCKHYNKDFGIEC 196 + SS +Y + V ++ Y K E+ K+ ++ Sbjct: 141 FTSSIGTVYMDPNTSRDVVVDESYWSDLEHCKNTKNWYCYGKTVAEQSAWDIAKENQVDL 200 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEG-V 255 + + GP + + + + + T+S+ + + + Sbjct: 201 VVVNPVVVLGPL--LQPTINASTIHILKYLNGAAKTYV-----NATQSYVHVKDVALAHL 253 Query: 256 LRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRG--RNSDNNLI 313 L + I + + E+ E++ + + + R N + Sbjct: 254 LVYETNSASGRY-ICCETALHRGEVVEILAKYFPEYPLPTKCSDEKNPRVKPYKFSNQKL 312 Query: 314 KEK-LGWAPNMRLKEGLRITYFWIKE 338 K+ L + P +K+ L T ++E Sbjct: 313 KDLGLEFTP---VKQCLYDTVRSLQE 335 >4KTT-E nrPDB Length = 327 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 54/320 (16%), Positives = 108/320 (33%), Gaps = 38/320 (11%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 N ++ +TGA G + + + + + + +++ E + +L+D + + + Sbjct: 21 NRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFE-----QVNLLDSNAVHHII 75 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 + + + AA+ +++ N S N+ + A G Y SS + Sbjct: 76 HDFQPH-VIVHCAAERRPDV-VENQPDAASQLNVDASGNLAKEAAAVGAF-LIYISSDYV 132 Query: 147 YPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYG 206 + + + P + YG KL E+ + + + R +YG Sbjct: 133 FD--------GTNPPYREEDIPAPLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYG 180 Query: 207 PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDF--- 263 E A K Q S M D Q R T + + +L + Sbjct: 181 EVEKL---EESAVTVMFDKVQFSNKSANM--DHWQQRFPTHVKDVATVCRQLAEKRMLDP 235 Query: 264 --REPVNIGSDEMVSMNEMAEMVLSFEEKK----LPIHHIPGPEGVRGRNS--DNNLIKE 315 + + +E ++ EMA + PI P R RN+ D + + E Sbjct: 236 SIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL-E 294 Query: 316 KLGWAPNMRLKEGLRITYFW 335 LG + G++ + W Sbjct: 295 TLGIGQRTPFRIGIKESL-W 313 >3SC6-A nrPDB Length = 287 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 47/311 (15%), Positives = 104/311 (33%), Gaps = 46/311 (14%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 ++ ITGA G + + L E + + D K L+D+ + +V Sbjct: 7 RVIITGANGQLGKQLQEELNPEEYDIYPFDKK---------------LLDITNISQVQQV 51 Query: 89 TEGV--DHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 + + + + AA + + N + + N+ A+++ G + Y S+ + Sbjct: 52 VQEIRPHIIIHCAAYTKVDQA-EKERDLAYVINAIGARNVAVASQLVGA-KLVYISTDYV 109 Query: 147 Y-PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIY 205 + + + + P + YG K A E+ K + + I R +Y Sbjct: 110 FQGDRPE--------GYDEFHNPAPINIYGASKYAGEQFVKELHNKY----FIVRTSWLY 157 Query: 206 GPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFRE 265 G +G R + + + D Q S T++ + + +L + Sbjct: 158 GKYGN------NFVKTMIRLGKER-EEISVVAD--QIGSPTYVADLNVMINKLIHTSLYG 208 Query: 266 PVNIGSDEMVSMNEMAEMVLSFEEKKLPI-----HHIPGPEGVRGRNSDNNLIKEKLGWA 320 ++ + S E A+ + S+ K+ + + + + G+ Sbjct: 209 TYHVSNTGSCSWFEFAKKIFSYANMKVNVLPVSTEEFGAAAARPKYSIFQHNMLRLNGFL 268 Query: 321 PNMRLKEGLRI 331 +EGL Sbjct: 269 QMPSWEEGLER 279 >4QUK-A nrPDB Length = 319 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 106/327 (32%), Gaps = 34/327 (10%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH-----------MTEDMFCDEFHLVD 78 + +TGA G+IAS + R L H G+ V A+ N+ E + + +L++ Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKLDGAKERLQLFKANLLE 62 Query: 79 LRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMI-EAARINGIKR 137 ++ ++ G VF+ A+ ++ + ++ + N++ A+ +KR Sbjct: 63 EGAFDSVVQGCHG---VFHTASPFYHD--VKDPQAELIDPALKGTLNVLNSCAKSPSLKR 117 Query: 138 FFYASSAC--IYPEFKQLETTNVSLKESDAWP--AEPQDAYGLEKLATEELCKHYNKDFG 193 SS Y + V A+ Y + EE + K+ Sbjct: 118 VVLTSSIAAVAYNGKPRTPDVVVDETWFTDADFCAKSNLWYVVSATLAEEAAWKFVKENN 177 Query: 194 IECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVE 253 I+ + GP AA F G + + + Sbjct: 178 IDMVTINPAMVIGP---LLQPVLNTSAAAILNLINGAQTFPNASFG-----WVNVKDVAN 229 Query: 254 GVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLS-FEEKKLPIHHIPGPEGVRGRNSDNNL 312 + ++ + + + +E+ ++ + +LP V Sbjct: 230 AHILAYENASASGRHCLVERVAHYSEVVRILRELYPSLQLPEKCADDKPYVPIYQVSKEK 289 Query: 313 IKEK-LGWAPNMRLKEGLRITYFWIKE 338 K L + P L+ ++ T +KE Sbjct: 290 AKSLGLEYTP---LEVSIKETVESLKE 313 >4WPG-A nrPDB Length = 289 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 52/321 (16%), Positives = 99/321 (30%), Gaps = 44/321 (13%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 I ITG+ G + + + L G +A D + + ED + Sbjct: 7 ILITGSNGQLGTELRYLLDERGVDYVAVDVAEMDITNEDKV-------------EAVFAQ 53 Query: 90 EGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYPE 149 V++ AA ++ N S N+ +A G Y S+ ++ Sbjct: 54 VKPTLVYHCAAYTAVDAAEDEGKALNEAINVTGSENIAKACGKYGAT-LVYISTDYVFDG 112 Query: 150 FKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPFG 209 K V + + +P+ YG K E + Y + F I R YG Sbjct: 113 NKP-----VGQEWVETDHPDPKTEYGRTKRLGELAVERYAEHFYI-IRTAWVFGNYG--- 163 Query: 210 TWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFR-EPVN 268 K + + R + D ++T E + LT++ + Sbjct: 164 -------KNFVFTMEQLAENHSRLTVVNDQHGRPTWT--RTLAEFMCYLTENQKAFGYYH 214 Query: 269 IGSD--EMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLK 326 + +D E + + A+ +L K + +P + K L N+ Sbjct: 215 LSNDAKEDTTWYDFAKEIL----KDKAVEVVPVDSS-----AFPAKAKRPLNSTMNLDKA 265 Query: 327 EGLRITYFWIKEQIEKEKAKG 347 + +E ++ +G Sbjct: 266 KATGFVIPTWQEALKAFYQQG 286 >5U9C-A nrPDB Length = 292 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 102/314 (32%), Gaps = 42/314 (13%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 KI ITG G + +++ LK + VI E T ++ E + Sbjct: 7 KILITGGTGMLGAYVTSALKDTDYNVIV-----TERNTLNLSVPEAIFSYI--------T 53 Query: 89 TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYP 148 E D + + AA+ + +Y N + + + +AA+ G Y SS+ ++ Sbjct: 54 AEKPDVILHFAAETDVDLCEREPARAGIY-NHLATEQIAQAAKFCGAW-LLYLSSSNVFG 111 Query: 149 EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIY--- 205 L ++ P + YG KL E + I R Sbjct: 112 G-------EGKLSYNELDIPLPMNYYGRSKLIGESSVR---NACTNNHLIIR-AGWMIGG 160 Query: 206 GPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFRE 265 GP K ++ + + + D L S T + ++ Sbjct: 161 GPDKDHKF-----VGKIIQQIKAGSTSIKAVSDRLG--SITSAMQLCNFIIWAINKRHTG 213 Query: 266 PVNIGSDEMVSMNEMAEMV---LSFEEKKLPIHHIPGPEGVRGRNSDN--NLIKEKLGWA 320 ++ S +S ++A + L+F+ +P+H P S+ ++ L A Sbjct: 214 TLHFASSGTISRFDIACAIGDLLNFKGDIIPVHSSVFPLSAPRPYSEGIESIYMSILSDA 273 Query: 321 PNMRL-KEGLRITY 333 P L K L Sbjct: 274 PKPSLWKSDLAKYV 287 >4PVC-A nrPDB Length = 342 Score = 67.9 bits (164), Expect = 8e-12, Method: Composition-based stats. Identities = 53/344 (15%), Positives = 112/344 (32%), Gaps = 52/344 (15%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKK------NEHMTEDMFCDEFHLVDLRV 81 + + ++GA GFIA HI L E + VI S + E + + D+ Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTEAFGNNPKFSMEVVPDISK 60 Query: 82 MENCLKVTEG----VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARIN---G 134 ++ V + + V + A+ I + ++ ++ + + Sbjct: 61 LDAFDHVFQKHGKDIKIVLHTASPFCFD--ITDSERDLLIPAVNGVKGILHSIKKYAADS 118 Query: 135 IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAE-------PQDAYGLEKLATEELCKH 187 ++R SS + + +++ E PA P +AY K E+ Sbjct: 119 VERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAAWE 178 Query: 188 YNKD----FGIECRIGRFHNIYGPFGTWKGGREKA-----PAAFCRKAQTSTDRFEMWGD 238 + ++ E ++GP K ++ E++G Sbjct: 179 FLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPELFGG 238 Query: 239 GLQTRSFTFIDECVEG-VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHI 297 + + + + ++ K + I S+ +M ++ +++ P+ Sbjct: 239 ------YIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILNE----DFPVLKG 288 Query: 298 PGPEGVRGRNS---------DNNLIKEKLGWAPNMRLKEGLRIT 332 P G G + DN K+ LG+ LKE + T Sbjct: 289 NIPVGKPGSGATHNTLGATLDNKKSKKLLGFK-FRNLKETIDDT 331 >5B6K-A nrPDB Length = 366 Score = 64.8 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 117/358 (32%), Gaps = 51/358 (14%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHYVIAS-------DWKKNEHMTEDMFCDEFHLV 77 S + ++GA GFIA H+ R+L + + VI S D KN F E + Sbjct: 19 SHMTTVFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIFKGGDFNYE-IVK 77 Query: 78 DLRVMENCLKVTEG----VDHVFNLAADMG-GMGFIQSNHSVIMYNNTMISFNMIEAARI 132 D+ V E + V + A+ I+ + ++ + ++E+ + Sbjct: 78 DISDPTAFDHVFEKHGKDIKVVLHTASPFHFNTTDIEKD---LLIPAVNGTKGILESIKK 134 Query: 133 NG---IKRFFYASS--------ACIYPEFKQLETTNVSLKES--DAWPAEPQDAYGLEKL 179 ++R SS Y + T S + ++ ++P Y K Sbjct: 135 YAAQTVERVVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGSKK 194 Query: 180 ATEELCKHYNKD----FGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEM 235 E+ + + I ++GP + G++ + + Sbjct: 195 FAEKAAWDFYNANKDSVKFKLSIINPVYVFGPQNYVEPGKK-----ILNTSSEVINSLVH 249 Query: 236 WGDGLQTRSF----TFIDECVEG-VLRLTKSDFREPVNIGSDEMVSMNEMAEMVL----S 286 F + + + +L K + E + + + + +++ Sbjct: 250 LKKDDPLPEFAGGHIDVRDVAKAHILAFQKDELIEQRLMLHAGLFTTQTLLDIINEQFPE 309 Query: 287 FEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEK 344 + K G DN+ K+ LG+ + LK+ L T I + +E EK Sbjct: 310 LKGKIPAGKPGTGNPDDALTPVDNSKTKKLLGFE-FIDLKKDLYDT---ISQILEAEK 363 >6GCS-E nrPDB Length = 375 Score = 64.4 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 44/302 (14%), Positives = 95/302 (31%), Gaps = 52/302 (17%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIA----SDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 + GA GF+ S++ +L G V+ K++ +T D+ F +DLR +E+ + Sbjct: 58 VFGANGFLGSYLTAKLAKHGTTVVVPYREEMAKRHLKVTGDLGVVNFLEMDLRNLESIDE 117 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 D V NL ++ + + + + EA + + I R+ + S+ Sbjct: 118 AVRHSDIVVNLIG-----REYETKNFNYYDVHVEGARRIAEAVKKHNIARYIHVSA---- 168 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 +A P + + K E++ K I R ++G Sbjct: 169 ---------------FNAEIDSPSE-FNHTKGLGEQVTKDIVPWA----TIVRPAPMFGR 208 Query: 208 FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGV--LRLTKSDFRE 265 W R + + + + + + S + Sbjct: 209 EDKWFLDRMARSPCLVSANKFQETSNPV-----------HVIDVAAALERICFDDSTVAQ 257 Query: 266 PVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLGWAPNMRL 325 + + + ++ +MV K+ + HI P+ + + W P Sbjct: 258 TFELYGPQKFTQKQIIDMVSETLRKE--VRHIELPKALYQAYTKATQAI----WWPTYSP 311 Query: 326 KE 327 + Sbjct: 312 DQ 313 >1ZZE-A nrPDB Length = 342 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 38/196 (19%), Positives = 72/196 (36%), Gaps = 24/196 (12%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV--DLRVMENCLK 87 + +TGA GF+ASH+ +L G+ V + ++ D + + V+E+ LK Sbjct: 14 VLVTGANGFVASHVVEQLLEHGYKVRGTARSASKLANLQKRWDAKYPGRFETAVVEDMLK 73 Query: 88 VTEGVDHVFNLA---ADMGGMGFIQSNHSVIMYNNTMISFNMIEAARIN-GIKRFFYASS 143 D V A A + + + + ++ + N + AA +KRF SS Sbjct: 74 -QGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAATPSVKRFVLTSS 132 Query: 144 A-----------CIYPEFK--QLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNK 190 IY + K LE+ + + ++ P + Y K E + Sbjct: 133 TVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKTEAELAAWKFMD 192 Query: 191 D----FGIECRIGRFH 202 + F + + + Sbjct: 193 ENKPHFTLNAVLPNYT 208 >2GGS-A nrPDB Length = 273 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 45/295 (15%), Positives = 90/295 (30%), Gaps = 41/295 (13%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 ++ ITGA G + + RL E H VI +E + L D +E+ + Sbjct: 1 MRTLITGASGQLGIEL-SRLLSERHEVIKVYNS-----SEIQGGYKLDLTDFPRLEDFI- 53 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 + + D + N AA + N +++ A ++ + S+ ++ Sbjct: 54 IKKRPDVIINAAAMTDVDK-CEIEKEKAYKINAEAVRHIVRAGKVID-SYIVHISTDYVF 111 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 + P + YGL KL E + I R I+ Sbjct: 112 D--------GEKGNYKEEDIPNPINYYGLSKLLGETFAL------QDDSLIIRTSGIF-- 155 Query: 208 FGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPV 267 R K + K + G + + +L L + + Sbjct: 156 -------RNKGFPIYVYKTLKEGKTVFAF-KGYYSP--ISARKLASAILELLELRKTGII 205 Query: 268 NIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRN-----SDNNLIKEKL 317 ++ E +S E+A + + + G + D++ ++ L Sbjct: 206 HVA-GERISRFELALKIKEKFNLPGEVKEVDEVRGWIAKRPYDSSLDSSRARKIL 259 >1KC3-A nrPDB Length = 299 Score = 58.2 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 78/265 (29%), Gaps = 31/265 (11%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 + I + G G + + R L G+ +IA D H E + Sbjct: 1 MNILLFGKTGQVGWELQRSLAPVGN-LIALD----VHSKEFCGDFSNPKGVAETVRKLRP 55 Query: 88 VTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIY 147 D + N AA +S + N + +AA G Y S+ ++ Sbjct: 56 -----DVIVNAAAHTAVDKA-ESEPELAQLLNATSVEAIAKAANETGAWVVHY-STDYVF 108 Query: 148 PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 P + + P + YG KLA E+ + I R +Y Sbjct: 109 PGT-------GDIPWQETDATSPLNVYGKTKLAGEKALQDNCPKH----LIFRTSWVY-- 155 Query: 208 FGTWKGGREKAPAAFCRKAQTSTDRFEMWGD-GLQTRSFTFIDECVEGV-LRLTKSDFRE 265 G R A+ + G T + D + + L K + Sbjct: 156 ----AGKGNNFAKTMLRLAKERQTLSVINDQYGAPTGAELLADCTAHAIRVALNKPEVAG 211 Query: 266 PVNIGSDEMVSMNEMAEMVLSFEEK 290 ++ + + ++ A +V K Sbjct: 212 LYHLVAGGTTTWHDYAALVFDEARK 236 >4QQR-A nrPDB Length = 301 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 49/313 (15%), Positives = 96/313 (30%), Gaps = 46/313 (14%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 I G G+I + + + +G I + + + + D+ + Sbjct: 16 LIYGKTGWIGGLLGKLCEAQG---ITYTYGSG-----RLQDRQSIVADIESV-------- 59 Query: 91 GVDHVFNLAADMG--GMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYP 148 HVFN A G + + +S+ + N + + + R G+ YA + CI+ Sbjct: 60 KPSHVFNAAGVTGRPNVDWCESHKVETIRTNVAGTLTLADICREKGLVLINYA-TGCIFE 118 Query: 149 EFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGPF 208 + + + P Y K EEL K+Y + R+ ++ P Sbjct: 119 YDSGHPLGSGIGFKEEDTPNFTGSFYSKTKAMVEELLKNYENVCTLRVRMPISSDLTNPR 178 Query: 209 GTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVN 268 + T D + + + K + N Sbjct: 179 NFITKIARYEKVVDIPNSMTILDEL------------------LPISIEMAKRNLTGIYN 220 Query: 269 IGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNS-------DNNLIKEKLGWAP 321 + +VS NE+ EM + + + E + + D +K + + Sbjct: 221 FTNPGVVSHNEILEMYRDYIDPSFTWKNFTLEEQAKVIVAPRSNNELDATKLKTE--FPE 278 Query: 322 NMRLKEGLRITYF 334 M +KE L F Sbjct: 279 LMSIKESLIKFVF 291 >5YWN-A nrPDB Length = 334 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 44/332 (13%), Positives = 112/332 (33%), Gaps = 32/332 (9%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIAS-DWKKNEHMTEDMFCDEFHLVDLRVMEN- 84 + ++GA G++A I + +G+ V+ S ++ + ++ D+F ++V+E Sbjct: 2 TTSVFVSGATGYLAQQIIALVLSKGYKVVGSVRSEEKGANLKKLYGDDFSYEVVKVLEQK 61 Query: 85 --CLKVTEGVDHV---FNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAAR--INGIKR 137 + + V + A+ + ++ I+ + ++++ + I R Sbjct: 62 GAFDEALKKHPEVTIFLHTASPV--TFEVEDTEKEILIPAINGTKYVLQSIKDVAPQITR 119 Query: 138 FFYASSACIYPEFKQLETTNVSLKES-------DAWPAEPQDAYGLEKLATEELCKHYNK 190 Y SS ++L + +V L E+ + AY K E + + Sbjct: 120 VVYTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVLAYFGSKQFAERAAWEFVE 179 Query: 191 DFGIECRI--GRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGL---QTRSF 245 + I+GP + E+ A+ ++ D T +F Sbjct: 180 QEKPNFALSTVNPVYIFGP----QAKDEEVKGTLNHSAEMVNSVLKLNKDDDVPATTGTF 235 Query: 246 TFIDECVEGVLRL--TKSDFREPVNIGSD--EMVSMNEMAEMVLSFEEKKLPIHHIPGPE 301 + + + L E + + + ++ ++ KLP+ + Sbjct: 236 IDVRDVAKAHLAAFEKDEAKGERLLLSNTRFNGQTLLDVVRKNFPQLADKLPVGKPHSDD 295 Query: 302 GVRGRNSDNNLIKEKLGWAPNMRLKEGLRITY 333 + ++ K+ LG+ + + + Sbjct: 296 FSAFKEWNDKKTKKILGFE-YFDFETSVVDSI 326 >6G2J-P nrPDB Length = 377 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 37/276 (13%), Positives = 80/276 (28%), Gaps = 48/276 (17%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIA-----SDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 + GA GF+ ++ L G VI + + D+ F D R ++ Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLGQLTFLEWDARDKDSIR 117 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 K + + V NL ++ + I + +A++ G++RF + S Sbjct: 118 KAVQHSNVVINLIG-----REWETRNFDFEDVFVNIPRAIAQASKEAGVERFIHVSHLNA 172 Query: 147 YPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYG 206 + + ++ E + P E I R +I+G Sbjct: 173 SMKSSSKSLRSKAVGEKEVRSVFP------------------------EAIIIRPSDIFG 208 Query: 207 PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTK--SDFR 264 ++ F G + ++ + +G++ TK Sbjct: 209 -------REDRFLNHFANYRWFLAVPLVSLGF-KTVKQPVYVADVSKGIVNATKDPDAVG 260 Query: 265 EPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGP 300 + + + + + + IP P Sbjct: 261 KTFAFTGPNRYLLFHLVKYIFGMTHR----TFIPYP 292 >4B4O-A nrPDB Length = 298 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 39/325 (12%), Positives = 80/325 (24%), Gaps = 47/325 (14%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLK 87 +++ + G GFI + + + L GH V K + E Sbjct: 1 MRVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGP-------------GRITWDELAAS 47 Query: 88 VTEGVDHVFNLAAD--MGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSAC 145 D NLA + + + + + + + ++ A Sbjct: 48 GLPSCDAAVNLAGENILNPLRRWNETFQKEVLGSRLETTQLL----------------AK 91 Query: 146 IYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATE-----ELCKHYNKDFGIECRIGR 200 + Q V + + Y + + L + + R Sbjct: 92 AITKAPQPPKAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTR 151 Query: 201 FHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVL-RLT 259 + +GG + G G Q + I + + L Sbjct: 152 QVVVRSGVVLGRGGGAMGHMLLPFRLGLGGP----IGSGHQFFPWIHIGDLAGILTHALE 207 Query: 260 KSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKL-- 317 + +N + + E A+ F IP P V L Sbjct: 208 ANHVHGVLNGVAPSSATNAEFAQT---FGAALGRRAFIPLPSAVVQAVFGRQRAIMLLEG 264 Query: 318 -GWAPNMRLKEGLRITYFWIKEQIE 341 P L G + ++ + ++ Sbjct: 265 QKVIPRRTLATGYQYSFPELGAALK 289 >3PVZ-A nrPDB Length = 399 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 55/190 (28%), Gaps = 37/190 (19%) Query: 29 KISITGAGGFIASHIARRLKHEG----HYVIASDWKKNEHMTEDMFCDEFHLVDLRV--- 81 + + G G I + + + H V S+ E + + + D + Sbjct: 37 RFLVLGGAGSIGQAVTKEIFKRNPQKLHVVDISENNMVELVRDIRSSFGYINGDFQTFAL 96 Query: 82 ------MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYN-NTMISFNMIEAARING 134 + +K D+V NL+A + M + N + I+ + G Sbjct: 97 DIGSIEYDAFIKADGQYDYVLNLSALKHVRSEKDPFTLMRMIDVNVFNTDKTIQQSIDAG 156 Query: 135 IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGI 194 K++F S+ A P + G K E K I Sbjct: 157 AKKYFCVSTDKA---------------------ANPVNMMGASKRIMEMFLMR--KSEEI 193 Query: 195 ECRIGRFHNI 204 RF N+ Sbjct: 194 AISTARFANV 203 >5GUP-L nrPDB Length = 377 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 37/284 (13%), Positives = 81/284 (28%), Gaps = 50/284 (17%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIA------SDWKKNEHMTEDMFCDEFHLVDLRVMENC 85 + GA GF+ ++ L G VI D M D+ F + + ++ Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVIVPYRCEPYDTMHLRPMG-DLGQIIFMEWNGKDKDSI 116 Query: 86 LKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSAC 145 KV E + V NL ++ + I + + ++ G+++ + S Sbjct: 117 RKVVEHSNVVINLVG-----REWETKNFDFEDVFVKIPHAIAQVSKEAGVEKLIHIS--- 168 Query: 146 IYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIY 205 N +K Y K E+ + E I + +I+ Sbjct: 169 ---------HLNADIKSP--------SRYLRSKAVGEKEVRAAFP----EATIIKPSDIF 207 Query: 206 GPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTK--SDF 263 G ++ F G + +I + +G++ K Sbjct: 208 G-------REDRFLNYFASMRWFGGVPLISLGK-ETVKQPVYIVDVSKGIINAIKDPDAK 259 Query: 264 REPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRN 307 + + ++ + + + + +P P Sbjct: 260 GKTFAFVGPNRYLLFDLVQYIFAVAYRP----FLPYPLPHFAYR 299 >5OVL-A nrPDB Length = 300 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 53/173 (30%), Gaps = 31/173 (17%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 + +TG I IARRL +GH V + D+F + + D ++ K Sbjct: 71 VLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPD--DLFGVQCDVTDSAAVDRAFKEV 128 Query: 90 EGVDH-VFNLAADMGG------MGFIQSNHSVIMYNNTMISFNMIEAA----RINGIKRF 138 E V L A+ G M + ++ N +F + A + R Sbjct: 129 EEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASRTMQRKRFGRI 188 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 + S VS A Y K + + +++ Sbjct: 189 IFIGS--------------VSGMWGIGNQAN----YAAAKAGLIGMARSISRE 223 >5OVJ-A nrPDB Length = 256 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 53/173 (30%), Gaps = 31/173 (17%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 + +TG I IARRL +GH V + D+F + + D ++ K Sbjct: 27 VLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPD--DLFGVQCDVTDSAAVDRAFKEV 84 Query: 90 EGVDH-VFNLAADMGG------MGFIQSNHSVIMYNNTMISFNMIEAA----RINGIKRF 138 E V L A+ G M + ++ N +F + A + R Sbjct: 85 EEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASRTMQRKRFGRI 144 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 + S VS A Y K + + +++ Sbjct: 145 IFIGS--------------VSGMWGIGNQAN----YAAAKAGLIGMARSISRE 179 >2QYS-A nrPDB Length = 318 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 30/80 (37%), Gaps = 10/80 (12%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEF-------HLVDLRV 81 KI I G G+I +H+ + GH + T DEF +L Sbjct: 13 KILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTT---LLDEFQSLGAIIVKGELDE 69 Query: 82 MENCLKVTEGVDHVFNLAAD 101 E +++ + VD V + A Sbjct: 70 HEKLVELMKKVDVVISALAF 89 >1UZM-A nrPDB Length = 247 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 54/179 (30%), Gaps = 31/179 (17%) Query: 24 PSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVME 83 P + + +TG I IA+RL +GH V + + +F E + D ++ Sbjct: 12 PFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAP--KGLFGVEVDVTDSDAVD 69 Query: 84 NCLKVTEGVDHVFN-------LAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA----RI 132 E L+AD M + ++ N +F + + A + Sbjct: 70 RAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQR 129 Query: 133 NGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 N R + S VS A Y K + + ++ Sbjct: 130 NKFGRMIFIGS--------------VSGLWGIGNQAN----YAASKAGVIGMARSIARE 170 >1CYD-A nrPDB Length = 244 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 71/247 (28%), Gaps = 32/247 (12%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-----FHLVDLRVM 82 L+ +TGAG I + L G V+A ++ ++ C L D Sbjct: 8 LRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVDLGDWDAT 67 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 E L VD + N AA + F++ + S N+ R + Sbjct: 68 EKALGGIGPVDLLVNNAALVIMQPFLEVTKEAF---DRSFSVNL----------RSVFQV 114 Query: 143 SACIYPEFKQ--LETTNVSLKESDAWPAEPQDA-YGLEKLATEELCKHYNKDFGIECRIG 199 S + + + + V++ A P Y K A L K + G Sbjct: 115 SQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRV 174 Query: 200 RFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLT 259 N P F RK + R F +++ V +L L Sbjct: 175 NSVNPTVVLTDMGKKVSADPE-FARKLKER----------HPLRKFAEVEDVVNSILFLL 223 Query: 260 KSDFREP 266 Sbjct: 224 SDRSAST 230 >4NBT-A nrPDB Length = 240 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 31/182 (17%), Positives = 54/182 (29%), Gaps = 31/182 (17%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 ITG + IA EG VIA D + ++ ++ D+ +E + Sbjct: 10 VITGGAKGLGQAIALAYAEEGAKVIAGDLGDLTYSHPNVEGMYLNVTDVTGVEKFYQSVI 69 Query: 91 ----GVDHVFNLAA---DMGGMGFIQSNHSVIMYNNTMISFNMIE----AARINGIKRFF 139 +D + N A D ++ ++ N FN+ + NG Sbjct: 70 DKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNLTRLVGPQMQTNGYGSII 129 Query: 140 YASS-ACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRI 198 SS ++ Q Y K L + K+F ++ Sbjct: 130 NISSVVGVFGNIGQAN-------------------YAATKAGVIGLTMTWAKEFALKGAN 170 Query: 199 GR 200 R Sbjct: 171 VR 172 >2Q4B-A nrPDB Length = 253 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 61/165 (36%), Gaps = 20/165 (12%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFH--LVDLRVMENCL 86 + +TGA G + ++LK EG + ++ E + D+ ++ Sbjct: 6 TVLVTGASGRTGQIVYKKLK-EGSDKFVAKGLVRSAQGKEKIGGEADVFIGDITDADSIN 64 Query: 87 KVTEGVDHVFNLAADM------------GGMGFIQSNHSVIMYNNTMISFNMIEAARING 134 +G+D + L + + G FI + + + N I+AA++ G Sbjct: 65 PAFQGIDALVILTSAVPKMKPGFDPTKGGRPEFIFEDGQYPEQVDWIGQKNQIDAAKVAG 124 Query: 135 IKRFFYASS-ACIYPEFKQLETTNVSL----KESDAWPAEPQDAY 174 +K S P+ + N ++ ++++ + A+ Y Sbjct: 125 VKHIVVVGSMGGTNPDHPLNKLGNGNILVWKRKAEQYLADSGTPY 169 >1N5D-A nrPDB Length = 288 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 67/210 (31%), Gaps = 43/210 (20%) Query: 25 SENLKI-SITGAGGFIASHIARRLKHE--GHYVIAS-DWKKNEHMTEDMFC----DEFHL 76 S N ++ +TGA I I R L + G V+ + D + + + + FH Sbjct: 1 SSNTRVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQ 60 Query: 77 VDLRVMENCLKVTE-------GVDHVFNLAA---DMGGMGFIQSNHSVIMYNNTMISFNM 126 +D+ +++ + + G+D + N AA + + M N M + N+ Sbjct: 61 LDIIDLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPFHIQAELTMKTNFMGTRNV 120 Query: 127 IEAAR--INGIKRFFYASS-------ACIYPEFKQLETTNVSLKE--------------- 162 I R SS PE +Q + +E Sbjct: 121 CTELLPLIKPQGRVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVEDTKN 180 Query: 163 -SDAWPAEPQDAYGLEKLATEELCKHYNKD 191 YG+ K+ L + Y + Sbjct: 181 GVHRKEGWSDSTYGVTKIGVSVLSRIYARK 210 >2DKN-A nrPDB Length = 255 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 41/229 (17%), Positives = 66/229 (28%), Gaps = 36/229 (15%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 I+ITG+ I + + L GH VI D + D+ D V Sbjct: 4 IAITGSASGIGAALKELLARAGHTVIGIDRGQ-----ADIEADLSTPGGRETA--VAAVL 56 Query: 90 EGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIE-----AARINGIKRFFYASSA 144 + V + G+G +N +++ N +++ +R S A Sbjct: 57 DRCGGVLDGLVCCAGVGVTAANSGLVVAVNYFGVSALLDGLAEALSRGQQPAAVIVGSIA 116 Query: 145 CIYPEFKQLETTNVSL-------KESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECR 197 P +L L E + AY K A L + D+ Sbjct: 117 ATQPGAAELPMVEAMLAGDEARAIELAEQQGQTHLAYAGSKYAVTCLARRNVVDWAGRGV 176 Query: 198 IGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFT 246 N+ P A +A + R+ G TR F Sbjct: 177 RL---NVVAP---------GAVETPLLQASKADPRY-----GESTRRFV 208 >2NM0-A nrPDB Length = 253 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 52/189 (27%), Gaps = 34/189 (17%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMEN-CLKV 88 + +TG I IAR G V + E + + D +E ++ Sbjct: 24 VLVTGGNRGIGLAIARAFADAGDKVAITYRSGEPP--EGFLAVKCDITDTEQVEQAYKEI 81 Query: 89 TEGVDHVFNLAADMGG------MGFIQSNHSVIMYNNTMISFNMIE----AARINGIKRF 138 E V L A+ G M + + + ++ N +F +++ A R Sbjct: 82 EETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRVVKRANRAMLRAKKGRV 141 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRI 198 SS + N Y K + ++ G Sbjct: 142 VLISS--VVGLLGSAGQAN----------------YAASKAGLVGFARSLARELGSRNIT 183 Query: 199 GRFHNIYGP 207 N+ P Sbjct: 184 ---FNVVAP 189 >4AVY-A nrPDB Length = 242 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/176 (13%), Positives = 55/176 (31%), Gaps = 17/176 (9%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVI---ASDWKKNEHMTEDMFCDEFHLVDLRVMEN 84 ++ +TG I + IA + G V+ + + +E + D + ++ Sbjct: 12 QQVLVTGGSSGIGAAIAMQFAELGAEVVALGLDADGVHAPRHPRIRREELDITDSQRLQR 71 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 144 + +D + N A + + + ++ N+ A + + R A Sbjct: 72 LFEALPRLDVLVNNAGIS--RDREEYDLATFER---VLRLNLSAAMLASQLAR---PLLA 123 Query: 145 CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGR 200 + + + +D AY K A +L + ++ E Sbjct: 124 QRGGSILNIASMYSTFGSADRP------AYSASKGAIVQLTRSLACEYAAERIRVN 173 >1AE1-A nrPDB Length = 273 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 30/204 (14%), Positives = 57/204 (27%), Gaps = 43/204 (21%) Query: 20 EQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH--------MTEDMFC 71 E W + +TG I I L G +NE E Sbjct: 14 EGRWSLKGTTALVTGGSKGIGYAIVEELAGLG--ARVYTCSRNEKELDECLEIWREKGLN 71 Query: 72 DEFHLVDLRVMENCLKVTEGVDHVFN-----------LAADMGGMGFIQSNHSVIMYNNT 120 E + DL K+ + V HVF+ + F + ++++IM N Sbjct: 72 VEGSVCDLLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNF 131 Query: 121 MISFNMIEAAR----INGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGL 176 ++++ + A + + SS + + Y Sbjct: 132 EAAYHLSQIAYPLLKASQNGNVIFLSSIAGFSALPSV------------------SLYSA 173 Query: 177 EKLATEELCKHYNKDFGIECRIGR 200 K A ++ K ++ + Sbjct: 174 SKGAINQMTKSLACEWAKDNIRVN 197 >1BDB-A nrPDB Length = 277 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 45/144 (31%), Gaps = 26/144 (18%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFH-----LVDLRVMEN 84 + ITG + + R EG V D K+ ++ D + D+R +E+ Sbjct: 8 VLITGGASGLGRALVDRFVAEGAKVAVLD--KSAERLAELETDHGDNVLGIVGDVRSLED 65 Query: 85 -------CLKVTEGVDHVFNLAADMG--------GMGFIQSNHSVIMYNNTMISFNMIEA 129 C+ +D + A + + + + N + ++A Sbjct: 66 QKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYIHAVKA 125 Query: 130 A---RINGIKRFFY-ASSACIYPE 149 + + S+A YP Sbjct: 126 CLPALVASRGNVIFTISNAGFYPN 149 >2V6G-A nrPDB Length = 364 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 52/310 (16%), Positives = 87/310 (28%), Gaps = 46/310 (14%) Query: 31 SITGAGGFIASHIARRLKHEG-----HYVIASDWKKNEHMTED--MFCDEFHLVDLRVME 83 I G G I + +A L V + ED + + + D + Sbjct: 5 LIVGVTGIIGNSLAEILPLADTPGGPWKVYGVARRTRPAWHEDNPINYVQCDISDPDDSQ 64 Query: 84 NCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISF-----NMIEAARINGIKRF 138 L V HVF + + M+ N + + N+ + G K Sbjct: 65 AKLSPLTDVTHVFYVTWANRSTEQENCEANSKMFRNVLDAVIPNCPNLKHISLQTGRK-- 122 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRI 198 Y Y + E+ + E Y LE + EE+ K G+ + Sbjct: 123 HYMGPFESYGKI---ESHDPPYTEDLPRLKYMNFYYDLEDIMLEEV----EKKEGLTWSV 175 Query: 199 GRFHNIYG--PFGTWKGGREKAPAAFCRKAQTSTDRFEMWG---DGLQTRSFTFIDECVE 253 R NI+G P+ A K + RF DG +C + Sbjct: 176 HRPGNIFGFSPYSMMNLVGTLCVYAAICKHEGKVLRFTGCKAAWDGYS--------DCSD 227 Query: 254 GVLRLTK--------SDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRG 305 L E N+ + ++ +++ + EGV Sbjct: 228 ADLIAEHHIWAAVDPYAKNEAFNVSNGDVFKWKHFWKVLAEQFG----VECGEYEEGVDL 283 Query: 306 RNSDNNLIKE 315 + D KE Sbjct: 284 KLQDLMKGKE 293 >1QYC-A nrPDB Length = 308 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 46/116 (39%), Gaps = 11/116 (9%) Query: 29 KISITGAGGFIASHIARRLKHEGHY--VIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 +I + GA G+I H+A+ GH ++ + + + + + F ++ + Sbjct: 6 RILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSI 65 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYAS 142 DH + A I + S+ + + N+I+A + G + F+ S Sbjct: 66 D-----DHASLVEAVKNVDVVISTVGSLQIESQV----NIIKAIKEVGTVKRFFPS 112 >5ITV-A nrPDB Length = 255 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 52/191 (27%), Gaps = 36/191 (18%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIAS--DWKKNEHMTEDMFCDEFHLV--DLRVMEN 84 + ITG I + + V+ + D + E M D H V D+ Sbjct: 9 TVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITDEAA 68 Query: 85 CLKVTEGVDHVF------------NLAADMGGMGFIQSNH--SVIMYNNTMISFNMIEAA 130 C E H F + A + M N V + ++S + ++ Sbjct: 69 CQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMSKHALKHM 128 Query: 131 RINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNK 190 G ++ + AWP P AY K +L K Sbjct: 129 LAAGKGNII--NTCSVGG--------------LVAWPDIP--AYNASKGGVLQLTKSMAV 170 Query: 191 DFGIECRIGRF 201 D+ Sbjct: 171 DYAKHQIRVNC 181 >5MLM-A nrPDB Length = 411 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 83/284 (29%), Gaps = 42/284 (14%) Query: 15 KELEREQYWPSENLKISITGAGGFIASHIARRLKHEG-----HYVIASDWKKNEHMTED- 68 K + ++ P + I G G + + +A L V + ED Sbjct: 36 KRSDEDEALPKHSSVALIVGVTGIVGNSLAEILPLADTPSGPWKVYGVARRPRPAWNEDN 95 Query: 69 -MFCDEFHLVDLRVMENCLKVTEGVDHVFNL--AADMGGMGFIQSNHSVIMYNNTMISFN 125 + + D + + L + HVF + A + ++N ++ ++ N Sbjct: 96 PINYIRCDISDPKDTQEKLSPLTDITHVFYVTWANRSTEVERCEANGKMLKNVLDVVIPN 155 Query: 126 ---MIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATE 182 + + G K Y + + ET + E Y E L E Sbjct: 156 CPDLKHISLQTGRK--HYMGPFELIGKI---ETHDPPFTEDLPRLKFDNFYYTQEDLLFE 210 Query: 183 ELCKHYNKDFGIECRIGRFHNIYG--PFGTWKGGREKAPAAFCRKAQTSTDRFEMWG--- 237 E+ K G+ + R NI+G P+ A K + RF Sbjct: 211 EV----EKKEGLTWSVHRPGNIFGFSPYSMMNLVGTLCVYAAICKHEGKVLRFPGCKAAW 266 Query: 238 DGLQTRSFTFIDECVEGVLRLTK--------SDFREPVNIGSDE 273 DG +C + L E N+ + + Sbjct: 267 DGYS--------DCSDADLIAEHHIWAAVDPYAKNEAFNVSNGD 302 >4K6F-A nrPDB Length = 255 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 47/134 (35%), Gaps = 21/134 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIAS---DWKKNEHMTEDMFC----DEFHLVDLRVME 83 +TG G + ++ RL GH V+ + + + +M + VD+ + Sbjct: 15 VVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPVDVADHD 74 Query: 84 NCLKVTEG-------VDHVFNLAA---DMGGMGFIQSNHSVIMYNN----TMISFNMIEA 129 +C + E VD + N A DM + N ++ N ++ + + Sbjct: 75 SCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMTKPVCDG 134 Query: 130 ARINGIKRFFYASS 143 G R SS Sbjct: 135 MVERGWGRIVNISS 148 >5VT6-A nrPDB Length = 269 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 33/69 (47%), Gaps = 7/69 (10%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-------FHLVDLRVME 83 +TG G + + I+RRL G V S ++N+H++ + + + VD+ E Sbjct: 29 FVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVDVADFE 88 Query: 84 NCLKVTEGV 92 +C + E V Sbjct: 89 SCERCAEKV 97 >5NUE-A nrPDB Length = 332 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 34/107 (31%), Gaps = 11/107 (10%) Query: 26 ENLKISITGAGGFIASHIA----RRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRV 81 E +++ +TGA G I + R + + E + + L+D Sbjct: 4 EPVRVLVTGAAGQIGYALVPMIARGIMLGADQPVILHMLDIPPAAEALNGVKMELID-AA 62 Query: 82 MENCLKVTEGVDHV-----FNLAADMGGMGFIQ-SNHSVIMYNNTMI 122 V D V N+A +GG + +M N I Sbjct: 63 FPLLKGVVATTDAVEGCTGVNVAVMVGGFPRKEGMERKDVMSKNVSI 109 >1OOE-A nrPDB Length = 236 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 62/173 (35%), Gaps = 18/173 (10%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCD---EFHLVDLRVMENC 85 K+ + G G + S I K G+ V+ D N+ ++ D + + ++E Sbjct: 5 KVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADSNILVDGNKNWTEQEQSILEQT 64 Query: 86 LKVTEG--VDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASS 143 +G VD VF +A G + + + MI ++ +A + A++ Sbjct: 65 ASSLQGSQVDGVFCVAGGWAGGSASSKDF--VKNADLMIKQSVWSSAIAAKL-----ATT 117 Query: 144 ACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHY-NKDFGIE 195 QL ++ + + YG+ K A L KD G+ Sbjct: 118 HLKPGGLLQLTGAAAAMGPTPSMIG-----YGMAKAAVHHLTSSLAAKDSGLP 165 >2HRB-A nrPDB Length = 274 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 38/211 (18%), Positives = 65/211 (30%), Gaps = 60/211 (28%) Query: 31 SITGAGGFIASHIARRLKHE--GHYVIAS-DWKKNEHMTEDMFC----DEFHLVDLRVM- 82 +TGA I IAR L + G V+ + D + + + + FH +D+ + Sbjct: 6 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 65 Query: 83 ------ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVI-------MYNNTMISFNM--- 126 + K G++ + N AA + F + + N + NM Sbjct: 66 SIRALRDFLRKEYGGLNVLVNNAA----VAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 121 Query: 127 ----------------IEAARINGIK------RFFYASSACIYPEFKQL-----ETTNVS 159 ++ R RF S + L E T Sbjct: 122 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFH--SETLTEGDLVDLMKKFVEDTKNE 179 Query: 160 LKESDAWPAEPQDAYGLEKLATEELCKHYNK 190 + E + W P YG+ KL L + + Sbjct: 180 VHEREGW---PNSPYGVSKLGVTVLSRILAR 207 >3DWF-A nrPDB Length = 276 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 56/171 (32%), Gaps = 8/171 (4%) Query: 20 EQYWPS--ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV 77 E++ P + K+ +TGA I IA L G +V+ + K C E Sbjct: 2 EKFRPEMLQGKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGAA 61 Query: 78 DLR-VMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 + + +T + V MGG+ + NH ++YN I+ R + Sbjct: 62 SAHYIAGSMEDMTFAEEFVAEAGNLMGGLDMLILNH--VLYNRLTFFHGEIDNVRKSMEV 119 Query: 137 RFFY--ASSACIYPEFKQLETTNVSLKESDAWPAEPQ-DAYGLEKLATEEL 184 F S P Q + + + P Y K A + Sbjct: 120 NFHSFVVLSVAAMPMLMQSQGSIAVVSSVAGKITYPLIAPYSASKFALDGF 170 >3VZS-A nrPDB Length = 257 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 47/133 (35%), Gaps = 21/133 (15%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIASD----------WKKNEHMTEDMFCDEFHLVDLR- 80 +TG G I + I +RL +G V+A ++ + + D E ++ D Sbjct: 19 VTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDS 78 Query: 81 ---VMENCLKVTEGVDHVFNLAADMGGMGF---IQSNHSVIMYNN----TMISFNMIEAA 130 + VD + N A + F +++ ++ N ++ +I+ Sbjct: 79 TKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVIDGM 138 Query: 131 RINGIKRFFYASS 143 G R SS Sbjct: 139 ADRGWGRIVNISS 151 >5F5N-A nrPDB Length = 289 Score = 36.7 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 20/72 (27%), Gaps = 2/72 (2%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIAS--DWKKNEHMTEDMFCDEFHLVDLRVMEN 84 N I +TGA G R L G V A D + DL + Sbjct: 1 NRTILVTGATGTQGGATVRALLARGRPVRALVRDPGTDAARALAAAGVSLVTGDLNDQAS 60 Query: 85 CLKVTEGVDHVF 96 V VF Sbjct: 61 LRAAMADVHGVF 72 >1QYD-A nrPDB Length = 313 Score = 36.7 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 42/293 (14%), Positives = 79/293 (26%), Gaps = 65/293 (22%) Query: 29 KISITGAGGFIASHIARRLKHEGH---------YVIASDWKKNEHMTEDMFCDEFHLVDL 79 ++ I G G+I I GH V D + + + + L Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVLFRPEVVSNIDKVQMLLYFKQLGA-KLIEASL 64 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARING-IKRF 138 + + + VD V +A GG+ + ++EA + G IKRF Sbjct: 65 DDHQRLVDALKQVDVVI--SALAGGVLSHH----------ILEQLKLVEAIKEAGNIKRF 112 Query: 139 FYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIE--C 196 + + E P + + + I Sbjct: 113 L-----------PSEFGMDPDIMEHALQPGSIT-------FIDKRKVRRAIEAASIPYTY 154 Query: 197 RIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVL 256 Y + P D+ ++GDG + D+ + Sbjct: 155 VSSNMFAGYFAGSLAQLDGHMMPP---------RDKVLIYGDGNVKGIWVDEDDVGTYTI 205 Query: 257 RLTKS--------DFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPE 301 + R P+NI +S E+ ++ E+ L +I + Sbjct: 206 KSIDDPQTLNKTMYIRPPMNI-----LSQKEVIQIWERLSEQNLDKIYISSQD 253 >3SLK-A nrPDB Length = 795 Score = 36.3 bits (82), Expect = 0.020, Method: Composition-based stats. Identities = 18/140 (12%), Positives = 41/140 (29%), Gaps = 21/140 (15%) Query: 29 KISITGAGGFIASHIARRLKHE---GHYVIASDWKKNEHMTEDMFCDEFHLV-------- 77 + +TG G + + +AR L E + V+ S ++ Sbjct: 532 TVLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQAC 591 Query: 78 DLRVMENCLKVTEGV------DHVFNLAADMG---GMGFIQSNHSVIMYNNTMISFNMIE 128 D+ E KV + V + A + ++ + N++E Sbjct: 592 DVADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLLE 651 Query: 129 AARINGIKRFFYASSACIYP 148 + ++S + + Sbjct: 652 LI-DPDVALVLFSSVSGVLG 670 >1GEG-A nrPDB Length = 256 Score = 36.3 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 56/178 (31%), Gaps = 31/178 (17%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEH------MTEDMFCDEFHLVDLRVMEN 84 +TGAG I IA RL +G V +D+ + + VD+ + Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 85 CLKVTE-------GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKR 137 E G D + N A + I+S I+ +++ +K Sbjct: 66 VFAAVEQARKTLGGFDVIVNNAG-VAPSTPIES-----------ITPEIVDKVYNINVKG 113 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDA----YGLEKLATEELCKHYNKD 191 + A + E + E + + + + Y K A L + +D Sbjct: 114 VIWGIQAAV--EAFKKEGHGGKIINACSQAGHVGNPELAVYSSSKFAVRGLTQTAARD 169 >3ZV3-A nrPDB Length = 281 Score = 36.3 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 39/141 (27%), Gaps = 22/141 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWK---------KNEHMTEDMFCDEFHLVD-LR 80 ITG + + R EG V D + + D L D R Sbjct: 9 LITGGASGLGRALVDRFVAEGARVAVLDKSAERLRELEVAHGGNAVGVVGDVRSLQDQKR 68 Query: 81 VMENCLKVTEGVDHVFNLAADMG--------GMGFIQSNHSVIMYNNTMISFNMIEAARI 132 E CL +D + A I + I + N + ++A Sbjct: 69 AAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNVKGYIHAVKACLP 128 Query: 133 NGIKR----FFYASSACIYPE 149 + F S+A YP Sbjct: 129 ALVSSRGSVVFTISNAGFYPN 149 >3ORF-A nrPDB Length = 251 Score = 36.3 bits (82), Expect = 0.023, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 51/169 (30%), Gaps = 15/169 (8%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKN-EHMTEDMFCDEFHLVDLRVMENC 85 + I + G G + + + + K + I+ D+++N D V+E Sbjct: 22 SKNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFTIKDSGEEEIKSVIEKI 81 Query: 86 LKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSAC 145 + VD A G + MI N+ A +SA Sbjct: 82 NSKSIKVDTFVCAAGGWSGGNASSDEFLKSVKG--MIDMNLYSA-----------FASAH 128 Query: 146 IYPEFKQLETTNVSLKESDA-WPAEPQDAYGLEKLATEELCKHYNKDFG 193 I + V S A AYG K AT + K + G Sbjct: 129 IGAKLLNQGGLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENG 177 >3UN1-A nrPDB Length = 260 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 37/254 (14%), Positives = 73/254 (28%), Gaps = 37/254 (14%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVD----LRVMENC 85 + ITGA I + + R + + V+A+ D+ + R++ Sbjct: 31 VVITGASQGIGAGLVRAYRDRNYRVVATSRSIKPSADPDIHTVAGDISKPETADRIVREG 90 Query: 86 LKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYN---NTMISFNMIEAARINGIKRFFYAS 142 ++ +D + N A F++ +N N F++ + A +K+ Sbjct: 91 IERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFHITQRAAAEMLKQ----- 145 Query: 143 SACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFH 202 + T + + P L K + + +F Sbjct: 146 -----GSGHIVSITTSLVDQP--MVGMPSALASLTKGGLNAVTRSLAMEFSRSGVRV--- 195 Query: 203 NIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSD 262 N P PA M G I + V+ VL L + Sbjct: 196 NAVSP---GVIKTPMHPAETHSTLAGLHPVGRM---GE-------IRDVVDAVLYLEHAG 242 Query: 263 F--REPVNIGSDEM 274 F E +++ + Sbjct: 243 FITGEILHVDGGQN 256 >4E0B-A nrPDB Length = 313 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 36/109 (33%), Gaps = 8/109 (7%) Query: 25 SENLKISITGAGGFIASHIARRLKHE---GHYVIASDWKKNEHMTEDMFCDEFHLVDLR- 80 S +K+++ GA G I +A LK+ G + D V ++ Sbjct: 1 SNAMKVAVIGAAGGIGQALALLLKNRLPAGSDLALYDIAPVTPGVAADLSHIPTHVSIKG 60 Query: 81 -VMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIE 128 E+ EG D V G + + + N I ++ E Sbjct: 61 YAGEDPTPALEGADVVL---ISAGVARKPGMDRADLFNVNAGIVKSLAE 106 >3EZL-A nrPDB Length = 256 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 52/139 (37%), Gaps = 22/139 (15%) Query: 27 NLKIS-ITGAGGFIASHIARRLKHEGHYVIA---------SDWKKNEHMT-EDMFCDEFH 75 + +I+ +TG G I + I +RL +G V+A W +++ D + E + Sbjct: 12 SQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYASEGN 71 Query: 76 LVD----LRVMENCLKVTEGVDHVFNLAADMGGMGF---IQSNHSVIMYNN----TMISF 124 + D + + +D + N A + F + + ++ N ++ Sbjct: 72 VGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFNVTK 131 Query: 125 NMIEAARINGIKRFFYASS 143 +I+ G R SS Sbjct: 132 QVIDGMVERGWGRIINISS 150 >4F3Y-A nrPDB Length = 272 Score = 35.9 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 13/99 (13%), Positives = 37/99 (37%), Gaps = 3/99 (3%) Query: 27 NLKISITGAGGFIASHIARRLK--HEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMEN 84 ++KI+I GA G + + + + V A D + + +D + + ++ Sbjct: 7 SMKIAIAGASGRMGRMLIEAVLAAPDATLVGALDRTGSPQLGQDAGAFLGKQTGVALTDD 66 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS 123 +V D++ + G + + + + + + Sbjct: 67 IERVCAEADYLIDFTLPEGTLVHLDAALRHDVK-LVIGT 104 >4RZI-B nrPDB Length = 240 Score = 35.5 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 29/167 (17%), Positives = 57/167 (34%), Gaps = 10/167 (5%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVM-EN 84 E+ I +TG I + I + L+ G V +D + TE + ++ DL M Sbjct: 7 EDKVIVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNTEALGVV-ANVTDLESMTAA 65 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 144 ++T+ + V+ + A+ G + +++ N+ A IK F Sbjct: 66 AAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAY--SIKPFI----E 119 Query: 145 CIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKD 191 +Y S+ + Y K + K ++ Sbjct: 120 GMYERKAGSIVAISSISGERGNVGQTN--YSATKAGVIGMMKSLARE 164 >5PGZ-A nrPDB Length = 276 Score = 35.5 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 58/172 (33%), Gaps = 10/172 (5%) Query: 20 EQYWPS--ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV 77 E++ P + K+ +TGA I +A L G +V+ + + C E Sbjct: 9 EEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAA 68 Query: 78 DLRVMENCLKVTEGVDHVFNLAAD-MGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 + ++ + A MGG+ + NH I + + + I + R Sbjct: 69 SAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH--ITQTSLSLFHDDIHSVRRVMEV 126 Query: 137 RFFY---ASSACIYPEFKQLETTNVSLKESDAWPAEP-QDAYGLEKLATEEL 184 F S+A + P KQ + + +P Y K A + Sbjct: 127 NFLSYVVMSTAAL-PMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGF 177 >3BHI-A nrPDB Length = 276 Score = 35.5 bits (80), Expect = 0.041, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 65/207 (31%), Gaps = 50/207 (24%) Query: 31 SITGAGGFIASHIAR---RLKHEGHYVIASDWKKNEHMTEDMFC----DEFHLVDLRVM- 82 +TG I I R RL + A D + + + + FH +D+ + Sbjct: 8 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 67 Query: 83 ------ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVI-------MYNNTMISFNMIEA 129 + K G+D + N A G+ F ++ + M N + ++ Sbjct: 68 SIRALRDFLRKEYGGLDVLVNNA----GIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTE 123 Query: 130 A--RINGIKRFFYASS-------------------ACIYPEFKQLETTNVSLKESDAWPA 168 I R SS + E + + N ++++ Sbjct: 124 LLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVH 183 Query: 169 E----PQDAYGLEKLATEELCKHYNKD 191 + P AYG+ K+ L + + + Sbjct: 184 QKEGWPSSAYGVTKIGVTVLSRIHARK 210 >3TQH-A nrPDB Length = 321 Score = 35.1 bits (79), Expect = 0.047, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 48/112 (42%), Gaps = 6/112 (5%) Query: 30 ISITGAGGFIASHIARRL-KHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 + I G + H+A +L K +G VI + K+N + + ++ ++ + L + Sbjct: 156 VLIHAGAGGVG-HLAIQLAKQKGTTVITTASKRNHAFLKALGAEQC--INYHEEDFLLAI 212 Query: 89 TEGVDHVFNLAADMGGMGFIQSNHSV--IMYNNTMISFNMIEAARINGIKRF 138 + VD V +L G+ I I+ T+ + +IE A+ + F Sbjct: 213 STPVDAVIDLVGGDVGIQSIDCLKETGCIVSVPTITAGRVIEVAKQKHRRAF 264 >3RWB-A nrPDB Length = 247 Score = 35.1 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 46/140 (32%), Gaps = 18/140 (12%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASD---------WKKNEHMTEDMFCDEFHLVDLRV 81 +TGA I IA RL +G VI SD + D ++ Sbjct: 10 LVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASIGKKARAIAADISDPGSVKA 69 Query: 82 M-ENCLKVTEGVDHVFNLAADMGGMGFIQSN---HSVIMYNNTMISFNM----IEAARIN 133 + +T G+D + N A+ + + + + I+ N +F + + R Sbjct: 70 LFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRAGTDQMRAA 129 Query: 134 G-IKRFFYASSACIYPEFKQ 152 G R +S + Sbjct: 130 GKAGRVISIASNTFFAGTPN 149 >1IE3-A nrPDB Length = 312 Score = 35.1 bits (79), Expect = 0.056, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 34/108 (31%), Gaps = 8/108 (7%) Query: 28 LKISITGAGGFIASHIARRL---KHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVM-- 82 +K+++ GA G I +A L G + D V ++ Sbjct: 1 MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSG 60 Query: 83 ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA 130 E+ EG D V G + S + N I N+++ Sbjct: 61 EDATPALEGADVVL---ISAGVARKPGMDRSDLFNVNAGIVKNLVQQV 105 >3A28-C nrPDB Length = 258 Score = 34.7 bits (78), Expect = 0.066, Method: Composition-based stats. Identities = 25/197 (12%), Positives = 59/197 (29%), Gaps = 16/197 (8%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 +TG I I+ +L +G + +D E+ + L++ + + Sbjct: 6 MVTGGAQGIGRGISEKLAADGFDIAVADL----PQQEEQAAETIKLIEAADQKAVFVGLD 61 Query: 91 -----GVDHVFNLAADM--GGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYA-- 141 D + AA+ G + + + ++ ++ + F+ Sbjct: 62 VTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQ 121 Query: 142 SSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRF 201 +++ + E + + AY K A L + ++ + Sbjct: 122 AASRKFDELGVKGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGHTV-- 179 Query: 202 HNIYGPFGTWKGGREKA 218 N Y P G E+ Sbjct: 180 -NAYAPGIVGTGMWEQI 195 >5TQV-A nrPDB Length = 233 Score = 34.7 bits (78), Expect = 0.068, Method: Composition-based stats. Identities = 16/109 (14%), Positives = 32/109 (29%), Gaps = 10/109 (9%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 + I GA + R+ + +G VIA+ H +D+ E + Sbjct: 11 TVLIVGASRGLGREFVRQYQRDGWNVIATARDDASLAALRALGAHAHALDITQPEQIAAL 70 Query: 89 TEGVDHVFNLAADM----------GGMGFIQSNHSVIMYNNTMISFNMI 127 +D A + G + +M+ N ++ Sbjct: 71 GWKLDGERLDVAVVVSGVYGPRTEGVETIASDDFDTVMHTNVRGPMQLL 119 >2ZAT-A nrPDB Length = 260 Score = 34.4 bits (77), Expect = 0.075, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 62/166 (37%), Gaps = 5/166 (3%) Query: 20 EQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDL 79 E+ P EN +T + I IARRL +G +V+ S K+ E++ + + + + Sbjct: 7 ERRKPLENKVALVTASTDGIGLAIARRLAQDGAHVVVSSRKQ-ENVDRTVATLQGEGLSV 65 Query: 80 RVMENCLKVTEGVDHVFNLAADMGGMGFI---QSNHSVIMYNNTMISFNMIEAARINGIK 136 + E + + +A ++ G I + + N + + + +K Sbjct: 66 TGTVCHVGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVK 125 Query: 137 RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQ-DAYGLEKLAT 181 + A + K+ + + + A+ P Y + K A Sbjct: 126 ATVLMTKAVVPEMEKRGGGSVLIVSSVGAYHPFPNLGPYNVSKTAL 171 >2HSD-A nrPDB Length = 253 Score = 34.4 bits (77), Expect = 0.079, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 47/134 (35%), Gaps = 17/134 (12%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKK-NEHMTEDMFCD--EFHLVDLRVMENC 85 + ITG + + AR+ G V+ +D T D + +D+ + E+ Sbjct: 7 TVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTIEEDW 66 Query: 86 LKVTE-------GVDHVFNLAADMGGM----GFIQSNHSVIMYNNT---MISFNMIEAAR 131 +V VD + N A GM ++ V+ N T + +I A + Sbjct: 67 QRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIPAMK 126 Query: 132 INGIKRFFYASSAC 145 G SSA Sbjct: 127 DAGGGSIVNISSAA 140 >2AE2-A nrPDB Length = 260 Score = 34.4 bits (77), Expect = 0.080, Method: Composition-based stats. Identities = 35/222 (15%), Positives = 63/222 (28%), Gaps = 50/222 (22%) Query: 23 WPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFC----------D 72 W E +TG I I L G V + + + E C Sbjct: 5 WNLEGCTALVTGGSRGIGYGIVEELASLGASV----YTCSRNQKELNDCLTQWRSKGFKV 60 Query: 73 EFHLVDLRVMENCLKVTEGVDHVFN-----------LAADMGGMGFIQSNHSVIMYNNTM 121 E + DL ++ V + F+ + + ++S+IM N Sbjct: 61 EASVCDLSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFE 120 Query: 122 ISFNMIEAAR----INGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLE 177 ++++ A + + SS + + A P E YG Sbjct: 121 AAYHLSVLAHPFLKASERGNVVFISS----------------VSGALAVPYE--AVYGAT 162 Query: 178 KLATEELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAP 219 K A ++L + ++ + N GP E Sbjct: 163 KGAMDQLTRCLAFEWAKDNIRV---NGVGPGVIATSLVEMTI 201 >3U5T-A nrPDB Length = 267 Score = 34.4 bits (77), Expect = 0.084, Method: Composition-based stats. Identities = 28/136 (20%), Positives = 51/136 (37%), Gaps = 21/136 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCD-----------EFHLVDL 79 +TGA I + IA RL +G V+ ++ E++ + + D Sbjct: 31 IVTGASRGIGAAIAARLASDGFTVVI-NYAGKAAAAEEVAGKIEAAGGKALTAQADVSDP 89 Query: 80 RVMENCLKVTE----GVDHVFNLAADMGGMGFIQSNHSVI---MYNNTMISFNMI-EAAR 131 + E GVD + N A M ++ +V + N +FN + EAA+ Sbjct: 90 AAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTFNTLREAAQ 149 Query: 132 INGI-KRFFYASSACI 146 + R S++ + Sbjct: 150 RLRVGGRIINMSTSQV 165 >3F9I-A nrPDB Length = 249 Score = 34.4 bits (77), Expect = 0.086, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 42/126 (33%), Gaps = 13/126 (10%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIAS-----DWKKNEHMTEDMFCDE-FHLVDLRVMEN 84 ITGA I S IAR L G VI S K + +D + E +L + N Sbjct: 18 LITGASSGIGSAIARLLHKLGSKVIISGSNEEKLKSLGNALKDNYTIEVCNLANKEECSN 77 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVI-------MYNNTMISFNMIEAARINGIKR 137 + T +D + A I+ + N +++ I+ R Sbjct: 78 LISKTSNLDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFILNREAIKKMIQKRYGR 137 Query: 138 FFYASS 143 SS Sbjct: 138 IINISS 143 >3OEC-A nrPDB Length = 317 Score = 34.4 bits (77), Expect = 0.092, Method: Composition-based stats. Identities = 41/266 (15%), Positives = 74/266 (27%), Gaps = 47/266 (17%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHL-------------- 76 ITGA A RL +G ++A D + + + L Sbjct: 50 FITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLVEEQGRRI 109 Query: 77 ----VDLRVMENCLKVTE----GVDHVFNLAADMG------GMGFIQSNHSVIMYNNTMI 122 D+R + + V + H+ L +++G + S I+ N + Sbjct: 110 IARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDILQTNLIG 169 Query: 123 SFNMIEAARINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEP-QDAYGLEKLAT 181 ++ A R S + + + + + P Q Y K Sbjct: 170 AW---HACRA------VLPSMIE-----RGQGGSVIFVSSTVGLRGAPGQSHYAASKHGV 215 Query: 182 EELCKHYNKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAF--CRKAQTSTDRFEMWGDG 239 + L + G N G T EK F + T D E++ Sbjct: 216 QGLMLSLANEVGRHNIRVNSVNP-GAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQL 274 Query: 240 LQTR-SFTFIDECVEGVLRLTKSDFR 264 + ++ V L + R Sbjct: 275 TLLPIPWVEPEDVSNAVAWLASDEAR 300 >4UUP-A nrPDB Length = 341 Score = 34.4 bits (77), Expect = 0.093, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 21/59 (35%), Gaps = 3/59 (5%) Query: 25 SENLKISITGAGGFIASHIARRLKHE---GHYVIASDWKKNEHMTEDMFCDEFHLVDLR 80 SE + + ITGA G I +A R+ G + + + + L D Sbjct: 2 SEPIHVLITGAAGQIGYALAFRIAKGDLFGDRKVVLHLLEIPPAMKALEGVCMELQDCA 60 >3KYB-A nrPDB Length = 390 Score = 34.4 bits (77), Expect = 0.096, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 30/72 (41%), Gaps = 10/72 (13%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENC 85 ++ KI I G GF + I R+L +GH V H+ + + D R E Sbjct: 2 KSKKILIVG-AGFSGAVIGRQLAEKGHQV---------HIIDQRDHIGGNSYDARDSETN 51 Query: 86 LKVTEGVDHVFN 97 + V H+F+ Sbjct: 52 VMVHVYGPHIFH 63 >4CR6-A nrPDB Length = 271 Score = 34.0 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 13/37 (35%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTE 67 +TGA G I EG V+A D T Sbjct: 19 IVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATR 55 >3FTP-A nrPDB Length = 270 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 51/186 (27%), Gaps = 28/186 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 +TGA I IA L G VI + + + L E Sbjct: 32 IVTGASRGIGRAIALELARRGAMVIGTATTEAGAEGIGAAFKQAGL-------------E 78 Query: 91 GVDHVFNLAADMGGMGFIQSNHSVI-----MYNNTMISFNMI---------EAARINGIK 136 G V N+ ++S + NN I+ + + +A +K Sbjct: 79 GRGAVLNVNDATAVDALVESTLKEFGALNVLVNNAGITQDQLAMRMKDDEWDAVIDTNLK 138 Query: 137 RFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDA-YGLEKLATEELCKHYNKDFGIE 195 F S A + P K V++ P Y K + + ++ G Sbjct: 139 AVFRLSRAVLRPMMKARGGRIVNITSVVGSAGNPGQVNYAAAKAGVAGMTRALAREIGSR 198 Query: 196 CRIGRF 201 Sbjct: 199 GITVNC 204 >5T5Q-A nrPDB Length = 247 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 54/191 (28%), Gaps = 37/191 (19%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIA--SDWKKNEHMTEDMFCDE---FHLVDLR 80 EN + +TGA G I IA G ++ D + + + E D Sbjct: 8 ENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADAS 67 Query: 81 VMENCLKVTE-------GVDHVFNLAADMGGMGFIQS---NHSVIMYNNTMISFNMIEAA 130 ++ K G+D + A F + + + N F + + A Sbjct: 68 SADDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDGVFYLCKRA 127 Query: 131 R--INGIKRFFYASSACIY-PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKH 187 + +S Y + YG K A + + Sbjct: 128 LPALKEDSSIVTLASLAAYRGAYVNAH-------------------YGATKGAMVSMTRA 168 Query: 188 YNKDFGIECRI 198 +++ + R+ Sbjct: 169 LSRELAPKTRV 179 >4JRO-A nrPDB Length = 271 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 42/107 (39%), Gaps = 5/107 (4%) Query: 22 YWPSENLKI-----SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHL 76 Y+ S + + +TG I IA L EG + + E E H Sbjct: 19 YFQSNAMTLQGKVAVVTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLVAEHG 78 Query: 77 VDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS 123 V++ M+ + + E VD F A + G I N++ I +N ++ Sbjct: 79 VEVEAMKANVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMR 125 >4IIV-A nrPDB Length = 267 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 42/128 (32%), Gaps = 19/128 (14%) Query: 22 YWPSENLK--ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDL 79 Y+ S + + +TGA I IAR+L +G + + E + + + Sbjct: 19 YFQSNAMSRSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNG 78 Query: 80 RVMENCLKVTEGVDHVF-NLAADMGG----------------MGFIQSNHSVIMYNNTMI 122 R++ + E V + A G + +++ N Sbjct: 79 RLLSFDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDS 138 Query: 123 SFNMIEAA 130 +N+I+ Sbjct: 139 FYNVIQPC 146 >2PH3-A nrPDB Length = 245 Score = 33.2 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 62/196 (31%), Gaps = 9/196 (4%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVD--LRVMENCL 86 K ITGA I IA RL +G + + +N E++ + + V+ L Sbjct: 3 KALITGASRGIGRAIALRLAEDGFALAIH-YGQNREKAEEVAEEARRRGSPLVAVLGANL 61 Query: 87 KVTEGVDHVFNLAADM-GGMGFIQSNHSVIMYN-NTMISFNMIEAARINGIKRFFYASSA 144 E + + AA++ GG+ + +N + + EA + F + Sbjct: 62 LEAEAATALVHQAAEVLGGLDTLVNNAGITRDTLLVRMKDEDWEAVLEANLSAVFRTTRE 121 Query: 145 CIYPEFKQLETTNVSLKESDAWPAEP-QDAYGLEKLATEELCKHYNKDFGIECRIGRFHN 203 + K V++ P Q Y K + K++ N Sbjct: 122 AVKLMMKARFGRIVNITSVVGILGNPGQANYVASKAGLIGFTRAVAKEYAQRGITV---N 178 Query: 204 IYGPFGTWKGGREKAP 219 P E+ P Sbjct: 179 AVAPGFIETEMTERLP 194 >3V2G-A nrPDB Length = 271 Score = 33.2 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 36/189 (19%), Positives = 55/189 (29%), Gaps = 28/189 (14%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-------FHLVDLRVME 83 +TG I + IA+RL EG V + E + E D R E Sbjct: 35 FVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRAVAIRADNRDAE 94 Query: 84 NCLKVTE-------GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIK 136 + G+D + N A ++ + E +N Sbjct: 95 AIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFD-----------EVMAVNFRA 143 Query: 137 RFFYASSACIY-PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIE 195 F SA + + ++ T +L E WP Y K A L K +D G Sbjct: 144 PFVAIRSASRHLGDGGRIITIGSNLAELVPWPG--ISLYSASKAALAGLTKGLARDLGPR 201 Query: 196 CRIGRFHNI 204 + Sbjct: 202 GITVNIVHP 210 >3U9L-A nrPDB Length = 324 Score = 33.2 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 25/75 (33%), Gaps = 8/75 (10%) Query: 30 ISITGAGGFIASHIARRLKHEGHYV------IASDWKKNEHMTEDMFCDEFHLVDLRVME 83 I ITGA A L GH V I N D + VDLR +E Sbjct: 8 ILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARD--NDVDLRTLE 65 Query: 84 NCLKVTEGVDHVFNL 98 ++ VD + Sbjct: 66 LDVQSQVSVDRAIDQ 80 >3PPI-A nrPDB Length = 281 Score = 32.8 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 20/60 (33%), Gaps = 1/60 (1%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASDW-KKNEHMTEDMFCDEFHLVDLRVMEN 84 E ++G G + RRL +G V+ +D + D + V V Sbjct: 29 EGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRAEFVSTNVTSE 88 >2GAS-A nrPDB Length = 307 Score = 32.8 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 36/106 (33%), Gaps = 11/106 (10%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHY---VIASDWKKNEHMTEDMFCDEFH------ 75 +EN KI I G G I HI G+ ++ T++ D + Sbjct: 1 TEN-KILILGPTGAIGRHIVWASIKAGNPTYALVRKTITAANPETKEELIDNYQSLGVIL 59 Query: 76 -LVDLRVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNT 120 D+ E +K + VD V A + ++ ++ N Sbjct: 60 LEGDINDHETLVKAIKQVDIVICAAGRLLIEDQVKIIKAIKEAGNV 105 >5TEN-A nrPDB Length = 269 Score = 32.8 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 30/83 (36%), Gaps = 7/83 (8%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV-----DLRVME 83 +I++ GA G + ++ + H + V + + D L D+ V + Sbjct: 3 RIAVAGAAGRMGRNLVKAAHH--NPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCD 60 Query: 84 NCLKVTEGVDHVFNLAADMGGMG 106 + K + D + + A + Sbjct: 61 DLAKQIDQFDVIIDFTAPASTLN 83 >4I1I-A nrPDB Length = 345 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 25/183 (13%), Positives = 48/183 (26%), Gaps = 19/183 (10%) Query: 29 KISITGAGGFIASHIARRLKHEG----HYVIASDWKKNEHMTEDMFCDEFHLVDLR--VM 82 K+++TGA G I + + + E + + E L D ++ Sbjct: 26 KVAVTGAAGQIGYALVPLIARGALLGPTTPVELRLLDIEPALKALAGVEAELEDCAFPLL 85 Query: 83 ENCLKVTE---GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIE--AARINGIKR 137 + + + D V ++ N I E AA R Sbjct: 86 DKVVVTADPRVAFDGVAIAIMCGAFPRKAGMERKDLLEMNARIFKEQGEAIAAVAASDCR 145 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECR 197 + T + L +S P+ + +L + G+ Sbjct: 146 VV------VVGNPAN--TNALILLKSAQGKLNPRHVTAMTRLDHNRALSLLARKAGVPVS 197 Query: 198 IGR 200 R Sbjct: 198 QVR 200 >2GDZ-A nrPDB Length = 267 Score = 32.4 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 35/118 (29%), Gaps = 14/118 (11%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDW-KKNEHMTEDMFCDEFHL-------VDLRVM 82 +TGA I A L +G V DW + + ++F D+ Sbjct: 11 LVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQCDVADQ 70 Query: 83 ENCLKVTEG-VDHVFNLAADMGGMG-FIQSNHSVIMYNNTM----ISFNMIEAARING 134 + VDH L + G + N + N + ++ ++ Sbjct: 71 QQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQN 128 >3D3W-A nrPDB Length = 244 Score = 32.4 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 31/92 (33%), Gaps = 5/92 (5%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDE-----FHLVDLRVME 83 ++ +TGAG I + L G V+A + + + C L D E Sbjct: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 Query: 84 NCLKVTEGVDHVFNLAADMGGMGFIQSNHSVI 115 L VD + N AA F++ Sbjct: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAF 100 >1DIR-A nrPDB Length = 241 Score = 32.0 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 26/170 (15%), Positives = 55/170 (32%), Gaps = 23/170 (13%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMF---CDEFHLVDLRVM 82 E ++ + G G + S + + +V + D +NE + + D F +V Sbjct: 6 EARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVIVKMTDSFTEQADQVT 65 Query: 83 ENCLKVT--EGVDHVFNLAADMGGMGFIQSNH---SVIMYNNTMISFNMIEAARINGIKR 137 K+ + VD + +A G + +M+ ++ + + +K Sbjct: 66 AEVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKE 125 Query: 138 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKH 187 L +L + YG+ K A +LC+ Sbjct: 126 ----------GGLLTLAGAKAALDGTPGMIG-----YGMAKGAVHQLCQS 160 >3UW3-A nrPDB Length = 377 Score = 32.0 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 27/131 (20%), Positives = 53/131 (40%), Gaps = 18/131 (13%) Query: 27 NLKISITGAGGFIASHIARRLKHEGH----YVIASDWKKNEHMTEDMFCDEFHLVDLRVM 82 ++ + + G G + S + +R++ EG + +E L D + Sbjct: 4 SMNVGLVGWRGMVGSVLMQRMQEEGDFDLIEPVFFSTSNAGGKAPSFAKNETTLKDATSI 63 Query: 83 ENCLK-----VTEGVDH---VFNLAADMGGMGF-IQSNHSVIMYNNTMI-----SFNMIE 128 ++ K +G D+ VF G G+ I + S+ M ++ +I + N+I+ Sbjct: 64 DDLKKCDVIITCQGGDYTNDVFPKLRAAGWNGYWIDAASSLRMKDDAVIILDPVNLNVIK 123 Query: 129 AARINGIKRFF 139 A +NG K F Sbjct: 124 DALVNGTKNFI 134 >7MDH-A nrPDB Length = 375 Score = 32.0 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 37/86 (43%), Gaps = 6/86 (6%) Query: 12 YTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEG----HYVIASDWKKNEHMTE 67 Y K ++ + W + + I+++GA G I++H+ +L IA +E + Sbjct: 18 YDLKAEDKTKSW-KKLVNIAVSGAAGMISNHLLFKLASGEVFGQDQPIALKLLGSERSFQ 76 Query: 68 DMFCDEFHLVDLRVMENCLKVTEGVD 93 + L D + +V+ G+D Sbjct: 77 ALEGVAMELED-SLYPLLREVSIGID 101 >4G65-A nrPDB Length = 461 Score = 32.0 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 32/84 (38%), Gaps = 11/84 (13%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMEN 84 S +KI I G G + +A L E + + D K + + E D++ DLRV+ Sbjct: 1 SNAMKIIILG-AGQVGGTLAENLVGENNDITIVD-KDGDRLRE--LQDKY---DLRVVNG 53 Query: 85 CLKVTEGVDHVFNLAADMGGMGFI 108 + V + A + Sbjct: 54 HASHPD----VLHEAGAQDADMLV 73 >3MJ4-A nrPDB Length = 397 Score = 32.0 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 15/32 (46%), Gaps = 1/32 (3%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKN 62 I G GF S +A RL G V+ D + + Sbjct: 33 LIVG-AGFAGSVLAERLASSGQRVLIVDRRPH 63 >2G17-A nrPDB Length = 337 Score = 32.0 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 52/164 (31%), Gaps = 29/164 (17%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFH-----LVDLRV- 81 L I GA G+ + + + H I + + + H +VDL + Sbjct: 5 LNTLIVGASGYAGAELVSYVNRHPHMTITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQ 64 Query: 82 -MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFY 140 M + + VD VF A + + + + F++ A R+N Sbjct: 65 PMSDVRDFSADVDVVFLATAH-----EVSHDLAPQFLQAGCVVFDLSGAFRVNDR----- 114 Query: 141 ASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEEL 184 Y ++ L E Q YGL + ++L Sbjct: 115 ----AFYEKYYGFTHQYPELLE--------QAVYGLAEWNVDKL 146 >3WOH-A nrPDB Length = 251 Score = 31.7 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 43/144 (29%), Gaps = 22/144 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDM-------FCDEFHLVDLRVME 83 +TG + +A RL +G V + E + D+ E Sbjct: 15 LVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARSYRCDVSDAE 74 Query: 84 NCLKVTEGVDH--------VFNLAADMGGMGF--IQSNHSVIMYNNTMISFNMIEAARIN 133 + + V V N G+ ++ +M N +F I+A Sbjct: 75 QVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLFIKACYFG 134 Query: 134 GIKR----FFYASS-ACIYPEFKQ 152 I++ SS + ++ Q Sbjct: 135 FIRKRSGSIINISSVSGVFGSAGQ 158 >2LDB-A nrPDB Length = 317 Score = 31.7 bits (70), Expect = 0.56, Method: Composition-based stats. Identities = 13/120 (10%), Positives = 45/120 (37%), Gaps = 3/120 (2%) Query: 29 KISITGAGGFIASHIARRLKHEG--HYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCL 86 ++ + G GF+ + L ++G ++ D +++ + + M + + + ++ Sbjct: 8 RVVVIG-AGFVGASYVFALMNQGIADEIVLIDANESKAIGDAMDFNHGKVFAPKPVDIWH 66 Query: 87 KVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACI 146 + + G ++ N I +++E+ +G + F ++ + Sbjct: 67 GDYDDCRDADLVVICAGANQKPGETRLDLVDKNIAIFRSIVESVMASGFQGLFLVATNPV 126 >4J6F-A nrPDB Length = 382 Score = 31.7 bits (70), Expect = 0.56, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 30/89 (33%), Gaps = 5/89 (5%) Query: 15 KELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEF 74 + LER + E + +TGA G + S I + + G IA E D+ Sbjct: 197 RMLERARLAAGE--TVLVTGASGGVGSAIIQLARARGAVPIAVAGPGKEAAMLDIGAQAV 254 Query: 75 HL---VDLRVMENCLKVTEGVDHVFNLAA 100 DL +D V +L Sbjct: 255 VTRGQGDLAEAVEAASGGRPIDVVADLVG 283 >5LCX-A nrPDB Length = 316 Score = 31.7 bits (70), Expect = 0.57, Method: Composition-based stats. Identities = 35/177 (19%), Positives = 62/177 (35%), Gaps = 27/177 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 +TGA I I R+L +G VI + + + + L +L V EN V Sbjct: 11 LVTGANKGIGFEICRQLAEKGIIVIL----TSRNEKRGLEARQKLLKELNVSEN-RLVFH 65 Query: 91 GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSACIYPEF 150 +D V +LA+ FI+S +++ G+ ++ E+ Sbjct: 66 QLD-VTDLASVAAVAVFIKSKF---------GKLDIL--VNNAGVSGVEMVGDVSVFNEY 113 Query: 151 KQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYGP 207 + + + E+ A P K E + K +C + + YGP Sbjct: 114 IEADFKALQALEAGAKEEPPFKP----KANGEMIEKFEGAK---DCVVTNY---YGP 160 >3WYE-A nrPDB Length = 256 Score = 31.7 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 61/203 (30%), Gaps = 30/203 (14%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEH------MTEDMFCDEFHLVDLRVMEN 84 +TGAG I IA RL +G V +D+ + + VD+ + Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 85 CLKVTE-------GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKR 137 E G D + N A G+ I+ V + ++ + Sbjct: 66 VFAAVEQARKTLGGFDVIVNNA----GIAQIKPLLEVTEED--------LKQIYSVNVFS 113 Query: 138 FFYASSACIYPEFKQLE-TTNVSLKESDAWPAEP-QDAYGLEKLATEELCKHYNKDFGIE 195 F+ A + K+ ++ A P AY K A L + +D Sbjct: 114 VFFGIQAAVEAFKKEGHGGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQTAARDLAPL 173 Query: 196 CRIGRFHNIYGPFGTWKGGREKA 218 N Y P G E+ Sbjct: 174 GITV---NGYCPGIVGTGMWEQI 193 >3Q7I-A nrPDB Length = 543 Score = 31.7 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 1/71 (1%) Query: 34 GAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDM-FCDEFHLVDLRVMENCLKVTEGV 92 G G H +L H+G+ I D+ + + L + L + Sbjct: 372 GGVGTNGQHAFHQLLHQGNIFIPVDFIAIATSHHNYDNHQQALLANCFAQSQALMFGQSY 431 Query: 93 DHVFNLAADMG 103 D V+N G Sbjct: 432 DMVYNELLKSG 442 >3CLW-A nrPDB Length = 507 Score = 31.7 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 21/172 (12%), Positives = 45/172 (26%), Gaps = 32/172 (18%) Query: 148 PEFKQLETTNVSLKESDAWP-AEPQDAYGLEKLATEELCKHYNKDFGIECRIGRFHNIYG 206 ++ E V + P Y K A ++ ++ G+ F Sbjct: 75 GSYENREAKEVDNSWNRTECFLSPDGKYDFTKQAGQQWFMKAARERGMN--NFLFFTNSA 132 Query: 207 PFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREP 266 P+ + + C Q D+F D+ +++ + + Sbjct: 133 PYFMTRSASTVSTDQDCINLQ--NDKF---------------DDFARFLVKSAQHFREQG 175 Query: 267 VNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNSDNNLIKEKLG 318 ++ + E H EG +D + E+L Sbjct: 176 FHV------------NYISPNNEPNGQWHANSFQEGSFATKADLYRMVEELD 215 >3PXX-A nrPDB Length = 287 Score = 31.3 bits (69), Expect = 0.65, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 6/62 (9%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVT 89 + +TG A +L EG +I D + D+ +E+ L R +E Sbjct: 13 VLVTGGARGQGRSHAVKLAEEGADIILFD------ICHDIETNEYPLATSRDLEEAGLEV 66 Query: 90 EG 91 E Sbjct: 67 EK 68 >2O23-A nrPDB Length = 265 Score = 31.3 bits (69), Expect = 0.67, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 38/116 (32%), Gaps = 19/116 (16%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASD--WKKNEHMTEDMFCD----EFHLVDLRVMEN 84 ITG + A RL +G + D E + + + + + ++ Sbjct: 16 VITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQT 75 Query: 85 CLKVTEG----VDHVFNLAADM---------GGMGFIQSNHSVIMYNNTMISFNMI 127 L + +G VD N A G + ++ N M +FN+I Sbjct: 76 ALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 131 >3GRP-A nrPDB Length = 266 Score = 31.3 bits (69), Expect = 0.68, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 51/132 (38%), Gaps = 17/132 (12%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH------MTEDMFCDEFHLVDLRVM 82 K +TGA G I IAR +G V ++++ + +D+F +L D + + Sbjct: 29 KALVTGATGGIGEAIARCFHAQGAIVGLHGTREDKLKEIAADLGKDVFVFSANLSDRKSI 88 Query: 83 ENCLKV----TEGVDHVFNLAADMGGMGFIQS---NHSVIMYNNTMI----SFNMIEAAR 131 + +V EG+D + N A F++ + ++ N + +I + Sbjct: 89 KQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAASTLTRELIHSMM 148 Query: 132 INGIKRFFYASS 143 R +S Sbjct: 149 RRRYGRIINITS 160 >6BAL-A nrPDB Length = 335 Score = 31.3 bits (69), Expect = 0.70, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 37/112 (33%), Gaps = 8/112 (7%) Query: 22 YWPSENLKISITGAGGFIA---SHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVD 78 Y+ S +K+++ GA G I + + + G + D V+ Sbjct: 19 YFQSNAMKVAVLGAAGGIGQALALLLKLQLPAGTDLSLYDIAPVTPGVAVDVSHIPTAVN 78 Query: 79 LRVM--ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIE 128 ++ E+ EG D V G + S + N I +IE Sbjct: 79 VKGFSGEDPTPALEGADVVL---ISAGVARKPGMDRSDLFNINAGIVRGLIE 127 >1CIV-A nrPDB Length = 385 Score = 31.3 bits (69), Expect = 0.71, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 35/86 (40%), Gaps = 6/86 (6%) Query: 12 YTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEG----HYVIASDWKKNEHMTE 67 Y K E + W + + ++++GA G I++H+ +L I+ +E Sbjct: 28 YDLKAEEETKSW-KKIINVAVSGAAGMISNHLLFKLASGEVFGPDQPISLKLLGSERSFA 86 Query: 68 DMFCDEFHLVDLRVMENCLKVTEGVD 93 + L D + +V+ G+D Sbjct: 87 ALEGVAMELED-SLYPLLRQVSIGID 111 >4MOW-A nrPDB Length = 256 Score = 31.3 bits (69), Expect = 0.74, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 47/166 (28%), Gaps = 23/166 (13%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 +TGA I + IA+ L EG V+ + D R + V++ Sbjct: 18 IVTGASKGIGAAIAKALADEGAAVVV--NYASSKAGADAVVSAITEAGGRAVAVGGDVSK 75 Query: 91 GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNM--IEAARINGIKRFFYASSACIYP 148 D A I++ + + N + IEA +R F ++ Sbjct: 76 AAD------AQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITEEHYRRQF---DTNVFG 126 Query: 149 EFKQLETTNVSLKES----------DAWPAEPQDAYGLEKLATEEL 184 + L E + Y K A + + Sbjct: 127 VLLTTQAAVKHLGEGASIINISSVVTSITPPASAVYSGTKGAVDAI 172 >2X9N-A nrPDB Length = 288 Score = 31.3 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 38/114 (33%), Gaps = 21/114 (18%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIA------------SDWKKNEHMTEDMFCDEFHLVD 78 +TGA I IA +L G+ V+ +D E + C + L + Sbjct: 27 VVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVC-QADLTN 85 Query: 79 LR--------VMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISF 124 ++ +C + D + N A+ +Q +H T+ + Sbjct: 86 SNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHEDNSNGKTVETQ 139 >4NBV-A nrPDB Length = 246 Score = 30.9 bits (68), Expect = 0.84, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 51/181 (28%), Gaps = 20/181 (11%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKK------NEHMTEDMFCDEFHLVDLRVMEN 84 ITGA I A+R +G V+ D ++ + + VD+ + Sbjct: 9 IITGAAAGIGFATAQRFAEDGAIVVLCDVQEARVREAAARLAATGATVSAYRVDVTRRDE 68 Query: 85 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 144 + V LAA + + ++ +A +K F + A Sbjct: 69 VDAMVAAV-----LAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNCAQA 123 Query: 145 CIY-----PEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIECRIG 199 + L ++V + Y K K + ++ G + Sbjct: 124 VAGLMTEQGKGVILNASSVVGLYGNFGQTN----YAASKFGVIGFTKTWARELGPKGVRV 179 Query: 200 R 200 Sbjct: 180 N 180 >4UUO-A nrPDB Length = 340 Score = 30.9 bits (68), Expect = 0.85, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 12/26 (46%) Query: 26 ENLKISITGAGGFIASHIARRLKHEG 51 E + I ITGA G I + R+ Sbjct: 2 EPIHILITGAAGQIGYALTFRIAKGD 27 >4E6P-A nrPDB Length = 259 Score = 30.9 bits (68), Expect = 0.91, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 37/114 (32%), Gaps = 15/114 (13%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASD-----------WKKNEHMTEDMFCDEFHLVDL 79 ITG+ I A EG V +D M +D Sbjct: 12 LITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEIGPAAYAVQMDVTRQDSIDA 71 Query: 80 RVMENCLKVTEGVDHVFNLAA--DMGGMGFI-QSNHSVIMYNNTMISFNMIEAA 130 + + G+D + N AA D+ + I + ++ + N + ++AA Sbjct: 72 AIAATV-EHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFTLQAA 124 >2PNF-A nrPDB Length = 248 Score = 30.9 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 45/134 (33%), Gaps = 21/134 (15%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEH-----MTEDMFCDEFHLVDLRVM--- 82 +TG+ I IA +L G VI + + + + H V++ ++ Sbjct: 11 LVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGVEMNLLSEE 70 Query: 83 ------ENCLKVTEGVDHVFNLAADMGGMGFIQS---NHSVIMYNNTMISF----NMIEA 129 E + +G+D + N A F++ + ++ N +F N + Sbjct: 71 SINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVTQNSLRK 130 Query: 130 ARINGIKRFFYASS 143 R SS Sbjct: 131 MIKQRWGRIVNISS 144 >3WTC-A nrPDB Length = 262 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 17/32 (53%) Query: 32 ITGAGGFIASHIARRLKHEGHYVIASDWKKNE 63 +TGA I IA RL +G VI D K++ Sbjct: 13 VTGAAQGIGKAIALRLAKDGADVILLDVKQDT 44 >1RY6-A nrPDB Length = 360 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 38/109 (34%), Gaps = 19/109 (17%) Query: 270 GSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEG-----VRGRNSDNNLIKEKLGWAPNMR 324 G++ S+ + E + + + K +HIP + +R + +P + Sbjct: 257 GANINRSLLALKECIRAMDSDK---NHIPFRDSELTKVLRDIFVGKSKSIMIANISPTIS 313 Query: 325 LKEGLRITYFWIKEQIEKEKAKGSDVSLYGSSKVVGTQAPVQLGSLRAA 373 E T + S V G+SK+ G P L L ++ Sbjct: 314 CCEQTLNTLRY-----------SSRVKNKGNSKLEGKPIPNPLLGLDSS 351 >4BPC-A nrPDB Length = 582 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 30/75 (40%), Gaps = 1/75 (1%) Query: 296 HIPGPEGVRGRNSDNNLIKEKLGWAPNM-RLKEGLRITYFWIKEQIEKEKAKGSDVSLYG 354 H P P +++ + L + + G + T+ ++ K K + ++V Y Sbjct: 4 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 63 Query: 355 SSKVVGTQAPVQLGS 369 S+V+ +GS Sbjct: 64 HSRVILQPIEGIMGS 78 >4TVO-A nrPDB Length = 330 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 34/96 (35%), Gaps = 12/96 (12%) Query: 28 LKISITGAGGFIASHIARRLKHEG----HYVIASDWKKNEHMTEDMFCDEFHLVDLR--- 80 LK+++TGA G I + RL I + E + + L D Sbjct: 6 LKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDDCAFPL 65 Query: 81 -----VMENCLKVTEGVDHVFNLAADMGGMGFIQSN 111 + + K+ +GV + A G G +S+ Sbjct: 66 LSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSD 101 >4KMS-A nrPDB Length = 249 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 46/130 (35%), Gaps = 17/130 (13%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIA--SDWKKNEHMTEDMFCDEFHLVDLRVMENCLKV 88 +TG I A LK++G V+A E+ + + ++ E C + Sbjct: 14 IVTGGTRGIGKATALELKNKGLTVVANFFSNYDAAKEMEEKYGIKTKCWNVADFEECRQA 73 Query: 89 TEGVDHVFNLAADM----GGMGFIQSNHSVIM--YNNTM---------ISFNMIEAARIN 133 + ++ F + G+ + H + +N+ + +S +++E R Sbjct: 74 VKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMSSSVMEQMRNQ 133 Query: 134 GIKRFFYASS 143 R SS Sbjct: 134 DYGRIVNISS 143 >1YXM-A nrPDB Length = 303 Score = 30.1 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 11/27 (40%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIAS 57 +TG I I + L G V+ + Sbjct: 22 IVTGGATGIGKAIVKELLELGSNVVIA 48 >2PV7-A nrPDB Length = 298 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 16/34 (47%) Query: 25 SENLKISITGAGGFIASHIARRLKHEGHYVIASD 58 S+ KI I G G + AR L+ G+ + D Sbjct: 19 SDIHKIVIVGGYGKLGGLFARYLRASGYPISILD 52 >1JAY-A nrPDB Length = 212 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVIA 56 +++++ G G + +A RL GH ++ Sbjct: 1 MRVALLGGTGNLGKGLALRLATLGHEIVV 29 >1O89-A nrPDB Length = 345 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 18/35 (51%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH 64 I +TGA G + S L G+ V+A +++ H Sbjct: 171 IVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTH 205 >4V7E-CC nrPDB Length = 405 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 24/193 (12%), Positives = 52/193 (26%), Gaps = 32/193 (16%) Query: 148 PEFKQLETTNVSLKESDAWPAEPQ--------------DAYGLEKLATEELCKHYNKDFG 193 + +++++L E P P Y + + A + + +G Sbjct: 16 GDMATDNSSSLALAEVFRAPLRPDVVRFVHRLLSCNKRQPYAVSRRAGHQTS---AESWG 72 Query: 194 IECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSF-----TFI 248 + R + P G + A CR + M+ R + + Sbjct: 73 TGRAVSRIPRV--PGGGTHRAGQGAFGNMCRGGR-------MFAPTKTWRKWHRRVNVHL 123 Query: 249 DECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNS 308 L + V + ++ E+ ++ E G + Sbjct: 124 RRVAVAS-ALAATSVPSLVLARGHRIETVPELPLVISDSAESIEKTSQAIKILKQVGAYA 182 Query: 309 DNNLIKEKLGWAP 321 D K+ +G P Sbjct: 183 DAEKAKDSVGIRP 195 >4V3P-LD nrPDB Length = 372 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 24/193 (12%), Positives = 52/193 (26%), Gaps = 32/193 (16%) Query: 148 PEFKQLETTNVSLKESDAWPAEPQ--------------DAYGLEKLATEELCKHYNKDFG 193 + +++++L E P P Y + + A + + +G Sbjct: 16 GDMATDNSSSLALAEVFRAPLRPDVVRFVHRLLSCNKRQPYAVSRRAGHQTS---AESWG 72 Query: 194 IECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAQTSTDRFEMWGDGLQTRSF-----TFI 248 + R + P G + A CR + M+ R + + Sbjct: 73 TGRAVSRIPRV--PGGGTHRAGQGAFGNMCRGGR-------MFAPTKTWRKWHRRVNVHL 123 Query: 249 DECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEEKKLPIHHIPGPEGVRGRNS 308 L + V + ++ E+ ++ E G + Sbjct: 124 RRVAVAS-ALAATSVPSLVLARGHRIETVPELPLVISDSAESIEKTSQAIKILKQVGAYA 182 Query: 309 DNNLIKEKLGWAP 321 D K+ +G P Sbjct: 183 DAEKAKDSVGIRP 195 >6NRP-A nrPDB Length = 263 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 16/35 (45%) Query: 22 YWPSENLKISITGAGGFIASHIARRLKHEGHYVIA 56 Y+ S +I +TG+ I IA +L G V Sbjct: 19 YFQSMTRRILVTGSSRGIGKAIALQLAKAGFDVTV 53 >5ER0-A nrPDB Length = 518 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 16/33 (48%), Gaps = 1/33 (3%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIASD 58 E +I++ G G+I + +A GH V D Sbjct: 196 EAKRITVIG-AGYIGAELAEAYSTTGHDVTLID 227 >5IZ4-A nrPDB Length = 271 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 47/180 (26%), Gaps = 26/180 (14%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTED---------------MFCDEFH 75 ITG+ I + A R G V ++ + D Sbjct: 18 VITGSASGIGAATALRFAQAGWSVAIGNFDDSTRDAASTVEALCRDAGAQTLIFDADVGK 77 Query: 76 LVDLR-VMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNM--IEAARI 132 D R ++ + +D + N A + + + N+ + Sbjct: 78 DADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLIGLYQMTR 137 Query: 133 NGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQD-AYGLEKLATEELCKHYNKD 191 + ++SA T+ V++ AY K A L ++ Sbjct: 138 AAVPLLRESASAT-------RSTSVVNVSSLAGLNGTGSSIAYAASKGAVNTLTLSLARN 190 >5B1Y-A nrPDB Length = 270 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 11/32 (34%) Query: 26 ENLKISITGAGGFIASHIARRLKHEGHYVIAS 57 E +TG I R EG V+ + Sbjct: 22 ETTYALVTGGSRGIGRATVLRFAREGWSVVIA 53 >4DVJ-A nrPDB Length = 363 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 37/103 (35%), Gaps = 16/103 (15%) Query: 4 TNGTDYGAYTYKELEREQYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNE 63 T+ T + A+ + L+ + P I I G G + S IA ++ + + Sbjct: 150 TSITAWEAF-FDRLDVNKPVPGAAPAILIVGGAGGVGS-IAVQIARQRTDLTVIATASRP 207 Query: 64 HMTEDMFCDEFHLVDLRVMENCLKVTEGVDHVFNLAADMGGMG 106 E + H V +DH LAA++ +G Sbjct: 208 ETQEWVKSLGAHHV--------------IDHSKPLAAEVAALG 236 >3OSU-A nrPDB Length = 246 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 35/93 (37%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVMENCLKVTE 90 +TGA I IA +L EG+ V + E + + VD ++ + + Sbjct: 8 LVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADAD 67 Query: 91 GVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS 123 V + G + N++ I +N ++ Sbjct: 68 EVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMR 100 >2BC1-A nrPDB Length = 490 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 16/34 (47%), Gaps = 1/34 (2%) Query: 29 KISITGAGGFIASHIARRLKHEGHYVIASDWKKN 62 ++++ G G+I +A + +G V+ D Sbjct: 196 RVAVVG-AGYIGVELAEAFQRKGKEVVLIDVVDT 228 >5GXF-A nrPDB Length = 330 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 28/62 (45%), Gaps = 7/62 (11%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIA-------SDWKKNEHMTEDMFCDEFHLVDLRVM 82 + +TGA G + S L H G+ V A +D+ + T+ + DE + R + Sbjct: 153 VLVTGAAGGVGSVATAILAHLGYEVAAVTGRPETADYLTSLGATQIVARDEINETVKRPL 212 Query: 83 EN 84 E+ Sbjct: 213 ES 214 >3RSH-A nrPDB Length = 251 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 30/140 (21%), Positives = 44/140 (31%), Gaps = 17/140 (12%) Query: 21 QYWPSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHM-TEDMFCDEF----- 74 Q+ E +TGA I IA L G VI + ++ D D Sbjct: 6 QFMNLEGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMAL 65 Query: 75 HLVDLRVMENCLKVTE----GVDHVFNLAADMGG---MGFIQSNHSVIMYNN----TMIS 123 ++ + +E LK GVD + N A M + S IM N +S Sbjct: 66 NVTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLS 125 Query: 124 FNMIEAARINGIKRFFYASS 143 ++ R S Sbjct: 126 KAVLRGMMKKRQGRIINVGS 145 >3KZV-A nrPDB Length = 254 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 22/175 (12%), Positives = 46/175 (26%), Gaps = 37/175 (21%) Query: 30 ISITGAGGFIASHIARRLKHEGHYVIASDWKKNE---HMTEDMFCDEF--HLVDL----- 79 I +TG I I L + ++E ++ + D F + D+ Sbjct: 5 ILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDITEDSV 64 Query: 80 --RVMENCLKVTEGVDHVFNLAADMGGMGFIQ----SNHSVIMYNNTMISFNMIEAA--- 130 +++ +K +D + A + + + + + N +++ A Sbjct: 65 LKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVGIALPE 124 Query: 131 RINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELC 185 + SS AYG K A Sbjct: 125 LKKTNGNVVFVSSDAC------------------NMYFSSWGAYGSSKAALNHFA 161 >2YQ5-A nrPDB Length = 343 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 9/76 (11%) Query: 10 GAYTYK-ELEREQYWPSE-------NLKISITGAGGFIASHIARRLKHEGHYVIASDWKK 61 G + Y+ + + + WPS NL + + G G I S +A G VIA D Sbjct: 123 GEFRYRMDHDHDFTWPSNLISNEIYNLTVGLIGV-GHIGSAVAEIFSAMGAKVIAYDVAY 181 Query: 62 NEHMTEDMFCDEFHLV 77 N + +F V Sbjct: 182 NPEFEPFLTYTDFDTV 197 >6CI9-A nrPDB Length = 259 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 26/166 (15%), Positives = 42/166 (25%), Gaps = 29/166 (17%) Query: 31 SITGAGGFIASHIARRLKHEGHYVI------------ASDWKKNEHMTEDMFCDEFHLVD 78 +TG I IA + G V+ +D + D D Sbjct: 13 IVTGGSKGIGRGIAETFANAGVDVVITGRNQDDLDRTVADLSGTRGKVTAVRADVTDPED 72 Query: 79 L-RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMY---NNTMISFNMIEAARING 134 R + + G+D V A I N + +++AA Sbjct: 73 ARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTVYIVQAALQ-- 130 Query: 135 IKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLA 180 A +A + + + W YG K A Sbjct: 131 ------ALTASGHGRVVVTSSITGPITGYPGWSH-----YGASKAA 165 >3FI9-A nrPDB Length = 343 Score = 29.3 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 8/17 (47%), Positives = 13/17 (76%) Query: 29 KISITGAGGFIASHIAR 45 K++I GA G I S++A+ Sbjct: 10 KLTIVGAAGMIGSNMAQ 26 >3G4D-A nrPDB Length = 554 Score = 29.0 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 35/116 (30%), Gaps = 13/116 (11%) Query: 82 MENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFF-Y 140 M N + +D V L I+ I +NN ++ + + R Y Sbjct: 67 MANSTQKLAFIDSVQRLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSIRFRLLREHGY 126 Query: 141 ASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLEKLATEELCKHYNKDFGIEC 196 S ++ +FK + S SD + E Y + G + Sbjct: 127 NVSCDVFNKFKDEQGNFKSSVTSDV------------RGLLELYQASYLRVHGEDI 170 >4WLE-A nrPDB Length = 340 Score = 28.6 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 21/157 (13%), Positives = 42/157 (26%), Gaps = 16/157 (10%) Query: 27 NLKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLVDLRVM---- 82 N K+++ GA G I + L + +++ + T + D H+ + Sbjct: 26 NAKVAVLGASGGIGQPL--SLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYL 83 Query: 83 --ENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFY 140 E +G D V G + N I + A + + Sbjct: 84 GPEQLPDCLKGCDVVV---IPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMI- 139 Query: 141 ASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLE 177 C+ + P +G+ Sbjct: 140 ----CVIANPVNSTIPITAEVFKKHGVYNPNKIFGVT 172 >4LE5-A nrPDB Length = 430 Score = 28.6 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 16/38 (42%), Gaps = 2/38 (5%) Query: 330 RITYFWIKEQIEKEKAKGSDVSLYGSSKVVGTQAPVQL 367 + Y W E+++ + + +SK+ G P L Sbjct: 380 QKDYPW--EKLDALEQFKKLLKGELNSKLEGKPIPNPL 415 >1NSY-A nrPDB Length = 271 Score = 28.6 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 310 NNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKGSDVSLYG--SSKVVGTQAPVQL 367 I +L P++ K+ + ++K+ ++K AKG + + G S + G A + + Sbjct: 3 QEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAV 62 Query: 368 GSLRAADG 375 S+R G Sbjct: 63 ESIREEGG 70 >5UGJ-A nrPDB Length = 302 Score = 28.6 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 28/73 (38%), Gaps = 2/73 (2%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVI--ASDWKKNEHMTEDMFCDEFHLVDLRVMENC 85 LKI+I GA G + + + + V+ A + +E + D + + ++ Sbjct: 37 LKIAIAGANGRMGRVLVEAVNNHPDTVLSGALEHSGSEALGLDAGYAVGLKTGIAISDDV 96 Query: 86 LKVTEGVDHVFNL 98 V D + + Sbjct: 97 DAVLAQSDVLIDF 109 >6BDX-A nrPDB Length = 270 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 28/73 (38%), Gaps = 2/73 (2%) Query: 28 LKISITGAGGFIASHIARRLKHEGHYVI--ASDWKKNEHMTEDMFCDEFHLVDLRVMENC 85 LKI+I GA G + + + + V+ A + +E + D + + ++ Sbjct: 5 LKIAIAGANGRMGRVLVEAVNNHPDTVLSGALEHSGSEALGLDAGYAVGLKTGIAISDDV 64 Query: 86 LKVTEGVDHVFNL 98 V D + + Sbjct: 65 DAVLAQSDVLIDF 77 >2UVD-A nrPDB Length = 246 Score = 27.8 bits (60), Expect = 7.0, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 39/94 (41%), Gaps = 2/94 (2%) Query: 31 SITGAGGFIASHIARRLKHEGHYVIASDWKKNEHMTEDMFCDEFHLV-DLRVMENCLKVT 89 +TGA I IA L +G V+ ++ NE ++ + L D + + Sbjct: 8 LVTGASRGIGRAIAIDLAKQGANVVV-NYAGNEQKANEVVDEIKKLGSDAIAVRADVANA 66 Query: 90 EGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMIS 123 E V ++ D+ G I N++ + +N ++ Sbjct: 67 EDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMR 100 >1QO8-A nrPDB Length = 566 Score = 27.4 bits (59), Expect = 9.6, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 15/38 (39%), Gaps = 1/38 (2%) Query: 24 PSENLKISITGAGGFIASHIARRLKHEGHYVIASDWKK 61 PSE ++ + G G + + K G VI D Sbjct: 118 PSETTQVLVVG-AGSAGFNASLAAKKAGANVILVDKAP 154 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.126 0.330 Lambda K H 0.267 0.0380 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,518,163 Number of Sequences: 36641 Number of extensions: 507124 Number of successful extensions: 1926 Number of sequences better than 10.0: 198 Number of HSP's better than 10.0 without gapping: 136 Number of HSP's successfully gapped in prelim test: 109 Number of HSP's that attempted gapping in prelim test: 1515 Number of HSP's gapped (non-prelim): 253 length of query: 377 length of database: 10,336,785 effective HSP length: 99 effective length of query: 278 effective length of database: 6,709,326 effective search space: 1865192628 effective search space used: 1865192628 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.8 bits)