BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q93VD3 (482 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4CZT-A nrPDB 947 0.0 4D28-A nrPDB 563 e-161 5EZV-A nrPDB 279 2e-75 4CFF-A nrPDB 278 3e-75 2YZA-A nrPDB 275 4e-74 4CFH-A nrPDB 273 1e-73 4REW-A nrPDB 271 7e-73 4RED-A nrPDB 268 3e-72 3MN3-A nrPDB 265 4e-71 3H4J-B nrPDB 258 4e-69 4YNZ-A nrPDB 254 7e-68 5ES1-A nrPDB 250 8e-67 2QNJ-A nrPDB 250 1e-66 4CQG-A nrPDB 249 2e-66 5KZ7-A nrPDB 249 3e-66 4D2V-A nrPDB 239 3e-63 2HAK-A nrPDB 233 2e-61 6C9D-A nrPDB 231 5e-61 5WAX-A nrPDB 226 1e-59 5YKS-A nrPDB 217 9e-57 3ZUT-A nrPDB 214 9e-56 3UDB-A nrPDB 210 1e-54 3D2K-A nrPDB 202 2e-52 3UC3-A nrPDB 202 3e-52 4B8L-A nrPDB 200 1e-51 4UZD-A nrPDB 195 3e-50 4FG9-A nrPDB 193 2e-49 1FOT-A nrPDB 192 2e-49 5IG1-A nrPDB 192 2e-49 2JC6-A nrPDB 191 7e-49 5JZN-A nrPDB 190 1e-48 2BRG-A nrPDB 187 8e-48 5U6Y-A nrPDB 187 1e-47 2VZ6-A nrPDB 186 2e-47 2VN9-A nrPDB 186 2e-47 2JAM-A nrPDB 184 9e-47 3SOA-A nrPDB 182 2e-46 3F3Z-A nrPDB 182 4e-46 5JN2-A nrPDB 181 7e-46 3BHH-A nrPDB 181 7e-46 4I6B-A nrPDB 179 2e-45 3NCG-A nrPDB 177 6e-45 4JXF-A nrPDB 177 7e-45 3MA6-A nrPDB 177 7e-45 5X3F-B nrPDB 177 7e-45 4B6L-A nrPDB 176 1e-44 4WB7-A nrPDB 176 1e-44 5FG8-A nrPDB 176 1e-44 3DFA-A nrPDB 176 3e-44 2BDW-A nrPDB 174 6e-44 3TXO-A nrPDB 174 9e-44 5N23-A nrPDB 173 2e-43 3KK8-A nrPDB 173 2e-43 2YCR-A nrPDB 172 3e-43 4RGJ-A nrPDB 172 3e-43 4YZB-A nrPDB 171 5e-43 3HZT-A nrPDB 171 8e-43 4AF3-A nrPDB 171 9e-43 2W4O-A nrPDB 170 1e-42 2V7O-A nrPDB 170 1e-42 3LIJ-A nrPDB 170 2e-42 3DXN-A nrPDB 170 2e-42 3I6U-A nrPDB 169 2e-42 2Z7Q-A nrPDB 169 3e-42 6CMJ-A nrPDB 169 4e-42 5D9K-A nrPDB 168 4e-42 2J90-A nrPDB 168 5e-42 5YV8-A nrPDB 168 5e-42 4L42-A nrPDB 167 1e-41 4RLP-A nrPDB 166 2e-41 3TAC-A nrPDB 166 3e-41 5XZW-A nrPDB 165 4e-41 3KN6-A nrPDB 164 8e-41 3Q5I-A nrPDB 164 9e-41 4PDS-A nrPDB 164 1e-40 2JDO-A nrPDB 163 1e-40 4MVF-A nrPDB 162 3e-40 5KCV-A nrPDB 161 5e-40 3MV5-A nrPDB 161 6e-40 4C0T-A nrPDB 161 6e-40 3GUB-A nrPDB 160 1e-39 3DB8-A nrPDB 158 4e-39 3ORZ-A nrPDB 158 6e-39 4NIF-A nrPDB 157 7e-39 5FET-A nrPDB 157 7e-39 3HDN-A nrPDB 157 8e-39 2WTK-C nrPDB 156 1e-38 5DYK-A nrPDB 156 2e-38 2Y7J-A nrPDB 156 2e-38 2YAB-A nrPDB 155 4e-38 4JG6-A nrPDB 155 4e-38 1ZWS-A nrPDB 153 2e-37 2A27-A nrPDB 152 4e-37 3IS5-A nrPDB 151 8e-37 4WNO-A nrPDB 150 1e-36 6FDY-U nrPDB 150 2e-36 2OU7-A nrPDB 150 2e-36 2EHB-D nrPDB 148 4e-36 3A8W-A nrPDB 148 5e-36 4J52-A nrPDB 148 6e-36 4RA4-A nrPDB 147 1e-35 1VZO-A nrPDB 144 1e-34 4X7Q-B nrPDB 142 3e-34 5F9E-A nrPDB 142 4e-34 5LOH-A nrPDB 142 5e-34 1PHK-A nrPDB 141 7e-34 6BDL-A nrPDB 139 2e-33 6QAU-A nrPDB 139 3e-33 6ED6-A nrPDB 138 5e-33 4APC-A nrPDB 138 5e-33 3PFQ-A nrPDB 138 5e-33 2I0E-A nrPDB 138 5e-33 6BXI-A nrPDB 137 7e-33 6E9W-A nrPDB 137 8e-33 6CCF-A nrPDB 137 1e-32 4FR4-A nrPDB 135 5e-32 3UTO-A nrPDB 135 6e-32 1KOA-A nrPDB 135 6e-32 2HW6-A nrPDB 134 8e-32 2WQN-A nrPDB 132 3e-31 1NY3-A nrPDB 132 5e-31 2OZA-A nrPDB 131 6e-31 3KA0-A nrPDB 129 3e-30 3HKO-A nrPDB 129 3e-30 3DLS-A nrPDB 129 3e-30 5CEK-A nrPDB 128 6e-30 2X4F-A nrPDB 127 8e-30 6DC0-A nrPDB 127 9e-30 1KOB-A nrPDB 125 3e-29 5TUR-A nrPDB 125 3e-29 4AW2-A nrPDB 125 4e-29 4RC3-A nrPDB 125 5e-29 3BGP-A nrPDB 125 6e-29 5DBX-A nrPDB 122 3e-28 2XNP-A nrPDB 122 4e-28 3Q53-A nrPDB 122 5e-28 6FD3-A nrPDB 121 5e-28 5J5T-A nrPDB 120 9e-28 3FXW-A nrPDB 120 1e-27 6CKI-A nrPDB 120 1e-27 3TKU-A nrPDB 120 1e-27 4AU8-A nrPDB 120 2e-27 3DAK-A nrPDB 119 2e-27 4KS7-A nrPDB 119 4e-27 4FIE-A nrPDB 117 8e-27 3ORP-A nrPDB 117 1e-26 4JDH-A nrPDB 117 1e-26 2Q0N-A nrPDB 116 2e-26 4XBR-A nrPDB 116 2e-26 2UV2-A nrPDB 116 2e-26 6HXF-B nrPDB 115 4e-26 2VD5-A nrPDB 115 4e-26 4BBM-A nrPDB 114 8e-26 3ZDU-A nrPDB 114 8e-26 3COM-A nrPDB 113 2e-25 3LM0-A nrPDB 112 3e-25 2F57-A nrPDB 112 3e-25 6GU6-A nrPDB 111 6e-25 1TKI-A nrPDB 111 6e-25 1V0B-A nrPDB 110 1e-24 4EQM-A nrPDB 110 2e-24 5UUU-A nrPDB 110 2e-24 4X3F-A nrPDB 109 3e-24 3PVW-A nrPDB 109 3e-24 6E2O-A nrPDB 109 3e-24 4LG4-A nrPDB 109 3e-24 2BPM-A nrPDB 109 3e-24 4KRC-A nrPDB 109 3e-24 6AO5-A nrPDB 108 4e-24 4OW8-A nrPDB 108 4e-24 6B2Q-A nrPDB 108 5e-24 2XIK-A nrPDB 107 1e-23 4QMW-A nrPDB 106 2e-23 4C59-A nrPDB 105 3e-23 4U41-A nrPDB 104 7e-23 4OTD-A nrPDB 104 8e-23 1UA2-A nrPDB 103 2e-22 4CRS-A nrPDB 103 2e-22 3M42-A nrPDB 102 3e-22 4TNB-A nrPDB 102 3e-22 3PPZ-A nrPDB 102 4e-22 1ZXE-A nrPDB 101 6e-22 5L2Q-C nrPDB 101 8e-22 4AGU-A nrPDB 100 1e-21 1CM8-A nrPDB 100 2e-21 4M7I-A nrPDB 100 2e-21 2F9G-A nrPDB 100 2e-21 4FZF-B nrPDB 99 3e-21 3NIZ-A nrPDB 99 3e-21 5D7A-A nrPDB 99 4e-21 6DTL-A nrPDB 99 4e-21 4UY9-A nrPDB 98 7e-21 3GC0-A nrPDB 98 9e-21 5H2U-A nrPDB 97 1e-20 6CQF-A nrPDB 97 1e-20 1G3N-A nrPDB 96 3e-20 5EFQ-A nrPDB 96 3e-20 3DTC-A nrPDB 96 3e-20 4UYA-A nrPDB 96 4e-20 4XEY-B nrPDB 95 5e-20 4E93-A nrPDB 95 7e-20 1K9A-A nrPDB 95 7e-20 4BGQ-A nrPDB 95 8e-20 1U5R-A nrPDB 94 1e-19 3QA8-A nrPDB 94 2e-19 2FO0-A nrPDB 94 2e-19 4NST-A nrPDB 94 2e-19 5TQX-A nrPDB 94 2e-19 2GCD-A nrPDB 94 2e-19 4E7W-A nrPDB 93 3e-19 3NYO-A nrPDB 93 3e-19 5VO2-A nrPDB 93 3e-19 4KIK-B nrPDB 93 3e-19 6NPU-A nrPDB 93 3e-19 6DBN-A nrPDB 92 4e-19 5AIR-A nrPDB 92 5e-19 1BYG-A nrPDB 92 5e-19 5HVK-A nrPDB 92 6e-19 3OHT-A nrPDB 91 8e-19 4IC8-A nrPDB 91 8e-19 4QTB-A nrPDB 91 8e-19 5Z33-A nrPDB 91 1e-18 5HI2-A nrPDB 91 1e-18 4ZSG-A nrPDB 91 1e-18 5G6V-A nrPDB 90 2e-18 3GC9-A nrPDB 90 2e-18 2XYN-A nrPDB 90 2e-18 4LQP-A nrPDB 89 3e-18 3C51-A nrPDB 89 4e-18 2W96-B nrPDB 89 6e-18 3E7O-A nrPDB 88 9e-18 4Y83-A nrPDB 88 9e-18 5AP3-A nrPDB 87 1e-17 3MIA-A nrPDB 87 2e-17 4YHJ-A nrPDB 87 2e-17 4MYG-A nrPDB 86 3e-17 3HMP-A nrPDB 86 3e-17 4IDT-A nrPDB 86 3e-17 5ZTN-A nrPDB 86 4e-17 2WTK-B nrPDB 86 4e-17 4CSV-A nrPDB 86 4e-17 5AWM-A nrPDB 86 4e-17 4EWQ-A nrPDB 86 5e-17 5NGU-A nrPDB 86 5e-17 2PMN-X nrPDB 85 5e-17 6GVJ-A nrPDB 85 8e-17 4PWN-A nrPDB 85 8e-17 2ZMD-A nrPDB 85 9e-17 3VN9-A nrPDB 84 1e-16 4EBW-A nrPDB 84 1e-16 5HIE-A nrPDB 84 2e-16 6O6Q-A nrPDB 84 2e-16 5IKW-A nrPDB 83 2e-16 5X5O-A nrPDB 83 2e-16 4GS6-A nrPDB 83 2e-16 5O2C-A nrPDB 83 2e-16 5O2B-A nrPDB 83 3e-16 2Y4I-B nrPDB 83 3e-16 4G3E-A nrPDB 83 3e-16 4TPT-A nrPDB 82 4e-16 4AN9-A nrPDB 82 4e-16 4JLC-A nrPDB 82 4e-16 2J0K-A nrPDB 82 4e-16 3SXS-A nrPDB 82 5e-16 4XCU-A nrPDB 82 6e-16 4EUU-A nrPDB 82 6e-16 4EUT-A nrPDB 82 7e-16 4YFF-A nrPDB 81 8e-16 6NT9-A nrPDB 81 9e-16 5TE0-A nrPDB 81 1e-15 3UIU-A nrPDB 81 1e-15 2A1A-B nrPDB 81 1e-15 3OZ6-A nrPDB 81 1e-15 3FME-A nrPDB 80 2e-15 4NEU-A nrPDB 80 2e-15 1JNK-A nrPDB 80 2e-15 6O8B-A nrPDB 80 2e-15 5VD3-A nrPDB 80 2e-15 5O0Y-A nrPDB 80 2e-15 4H1J-A nrPDB 80 2e-15 2XS0-A nrPDB 80 2e-15 3FI2-A nrPDB 80 3e-15 4QNY-A nrPDB 79 3e-15 5Y86-A nrPDB 79 4e-15 6DBM-A nrPDB 79 4e-15 5UIU-A nrPDB 79 5e-15 1S9I-A nrPDB 79 6e-15 3RP9-A nrPDB 79 6e-15 5KKR-C nrPDB 78 7e-15 2PSQ-A nrPDB 78 7e-15 3QD2-B nrPDB 78 9e-15 3EQC-A nrPDB 77 1e-14 3E3P-A nrPDB 77 1e-14 3QGY-A nrPDB 77 2e-14 4Y93-A nrPDB 77 2e-14 4XI2-A nrPDB 77 2e-14 5X8I-B nrPDB 77 2e-14 3DKO-A nrPDB 76 3e-14 2H34-A nrPDB 76 3e-14 5EG3-A nrPDB 76 3e-14 4K33-A nrPDB 76 3e-14 3A4O-X nrPDB 76 4e-14 5B2L-A nrPDB 75 5e-14 3EB0-A nrPDB 75 5e-14 4OLI-A nrPDB 75 5e-14 3OMV-A nrPDB 75 6e-14 6E4F-A nrPDB 75 6e-14 2WO6-A nrPDB 75 9e-14 2HK5-A nrPDB 74 1e-13 4F0G-A nrPDB 74 1e-13 3TT0-A nrPDB 74 1e-13 5A46-A nrPDB 74 1e-13 3GQL-A nrPDB 74 2e-13 2BUJ-A nrPDB 74 2e-13 3IO7-A nrPDB 74 2e-13 5LPZ-A nrPDB 74 2e-13 5UNP-A nrPDB 74 2e-13 2VWV-A nrPDB 74 2e-13 2PZI-A nrPDB 74 2e-13 6CTH-A nrPDB 73 3e-13 2W1I-A nrPDB 73 3e-13 4Y12-A nrPDB 73 3e-13 5LPV-A nrPDB 72 4e-13 4HVI-A nrPDB 72 4e-13 2I6L-A nrPDB 72 4e-13 5WNL-A nrPDB 72 5e-13 4E20-A nrPDB 72 5e-13 4HZS-A nrPDB 72 5e-13 1U54-B nrPDB 72 6e-13 4O2Z-A nrPDB 72 6e-13 4P5Q-A nrPDB 72 7e-13 1AD5-A nrPDB 72 7e-13 1JPA-A nrPDB 71 9e-13 2H8H-A nrPDB 70 1e-12 6FYV-A nrPDB 70 1e-12 3N9X-A nrPDB 70 2e-12 4LFI-A nrPDB 70 3e-12 3NIE-A nrPDB 69 4e-12 3KUL-B nrPDB 69 4e-12 2PL0-A nrPDB 69 4e-12 5MJB-A nrPDB 69 5e-12 6F3F-A nrPDB 69 6e-12 1FVR-A nrPDB 68 7e-12 2Y6O-A nrPDB 68 8e-12 2QKW-B nrPDB 67 1e-11 3RAW-A nrPDB 67 2e-11 3QUP-A nrPDB 67 2e-11 5L6P-A nrPDB 67 2e-11 5SYS-A nrPDB 67 2e-11 2R2P-A nrPDB 66 3e-11 2JD5-A nrPDB 66 4e-11 3LMG-A nrPDB 66 4e-11 5M07-A nrPDB 66 4e-11 3PLS-A nrPDB 65 5e-11 3ALO-A nrPDB 65 6e-11 6HMD-A nrPDB 65 7e-11 5XVU-A nrPDB 65 7e-11 2DQ7-X nrPDB 65 9e-11 3LLT-A nrPDB 64 1e-10 4PDO-A nrPDB 64 1e-10 3SV0-A nrPDB 64 2e-10 5HLW-A nrPDB 64 2e-10 5GNK-A nrPDB 64 2e-10 2PVN-A nrPDB 64 2e-10 4M66-A nrPDB 64 2e-10 4F9B-A nrPDB 64 2e-10 4MD7-E nrPDB 64 2e-10 3PP0-A nrPDB 64 2e-10 3LZB-A nrPDB 63 2e-10 6EII-A nrPDB 63 3e-10 6GQK-A nrPDB 63 4e-10 4PL5-B nrPDB 62 4e-10 4IAN-A nrPDB 62 5e-10 3C1X-A nrPDB 62 5e-10 4FL3-A nrPDB 62 5e-10 3UIM-A nrPDB 62 5e-10 5XD6-A nrPDB 62 5e-10 5AMN-A nrPDB 62 5e-10 5U6B-A nrPDB 62 6e-10 4JRN-A nrPDB 62 6e-10 5C26-A nrPDB 62 7e-10 6J5U-C nrPDB 62 7e-10 4XLV-A nrPDB 61 9e-10 3V5Q-A nrPDB 61 1e-09 5TOS-A nrPDB 61 1e-09 4CRL-A nrPDB 61 1e-09 5WNO-A nrPDB 60 2e-09 5U6C-A nrPDB 60 2e-09 1U59-A nrPDB 60 2e-09 2RIO-A nrPDB 59 4e-09 1LUF-A nrPDB 59 4e-09 2QLU-A nrPDB 59 4e-09 2OZO-A nrPDB 58 7e-09 3BEA-A nrPDB 58 9e-09 2OGV-A nrPDB 58 1e-08 3MDY-A nrPDB 58 1e-08 1PY5-A nrPDB 58 1e-08 3I81-A nrPDB 58 1e-08 4AT3-A nrPDB 57 1e-08 3BBT-B nrPDB 57 1e-08 3SOC-A nrPDB 57 1e-08 4XUF-A nrPDB 57 1e-08 3HNG-A nrPDB 57 2e-08 5X02-A nrPDB 57 2e-08 3PG1-A nrPDB 57 2e-08 6HV0-A nrPDB 57 2e-08 4R7H-A nrPDB 57 2e-08 3G0E-A nrPDB 57 2e-08 4LRM-A nrPDB 57 2e-08 5FM2-A nrPDB 57 2e-08 3Q4U-A nrPDB 57 2e-08 3CJF-A nrPDB 56 3e-08 5FQD-C nrPDB 56 4e-08 3REP-A nrPDB 55 5e-08 3ZZW-A nrPDB 55 5e-08 5GRN-A nrPDB 55 9e-08 3KRL-A nrPDB 54 1e-07 5E8V-A nrPDB 54 1e-07 3VHK-A nrPDB 54 1e-07 6BSD-A nrPDB 54 2e-07 4TN6-A nrPDB 53 3e-07 5VC6-A nrPDB 53 3e-07 3MY0-A nrPDB 52 4e-07 6FER-A nrPDB 52 4e-07 6FEX-A nrPDB 52 5e-07 2ZFD-B nrPDB 52 5e-07 4XHH-A nrPDB 51 9e-07 4NT4-A nrPDB 51 9e-07 4WUA-A nrPDB 51 1e-06 4L00-A nrPDB 50 2e-06 5KMM-A nrPDB 50 2e-06 5X18-A nrPDB 50 2e-06 4XHL-A nrPDB 50 3e-06 6BFN-A nrPDB 50 3e-06 5VDK-A nrPDB 49 4e-06 5AR8-A nrPDB 49 4e-06 5OAT-A nrPDB 49 5e-06 4NFN-A nrPDB 49 5e-06 4BTK-A nrPDB 49 5e-06 3G2F-A nrPDB 49 5e-06 6J6I-B nrPDB 47 2e-05 4M69-B nrPDB 47 2e-05 3ZBF-A nrPDB 47 2e-05 5X1R-A nrPDB 47 2e-05 4BTF-A nrPDB 47 3e-05 5CLR-A nrPDB 47 3e-05 2X7G-A nrPDB 46 4e-05 2C47-A nrPDB 45 6e-05 3AOX-A nrPDB 45 8e-05 6EQI-C nrPDB 44 1e-04 5USZ-A nrPDB 44 1e-04 4MWI-A nrPDB 44 2e-04 2CHL-A nrPDB 42 4e-04 4OAU-C nrPDB 42 4e-04 1CSN-A nrPDB 42 6e-04 2CMW-A nrPDB 42 8e-04 4O1O-A nrPDB 41 0.001 4RT7-A nrPDB 41 0.001 3DZO-A nrPDB 39 0.006 3BYV-A nrPDB 38 0.009 4IX6-A nrPDB 38 0.010 6G4J-A nrPDB 38 0.010 2RSV-A nrPDB 37 0.015 2LAV-A nrPDB 37 0.028 5UV4-A nrPDB 35 0.066 4AZV-A nrPDB 35 0.078 4AZW-A nrPDB 35 0.11 4CI6-B nrPDB 34 0.11 2W1Z-A nrPDB 34 0.15 4CYJ-A nrPDB 33 0.31 4WOV-A nrPDB 32 0.43 5C01-A nrPDB 32 0.48 6BHC-A nrPDB 32 0.72 5VE6-A nrPDB 31 1.1 3Q60-A nrPDB 31 1.2 6GOL-A nrPDB 31 1.3 5DMZ-A nrPDB 31 1.3 5UU1-A nrPDB 31 1.5 6EWX-A nrPDB 30 1.6 5UG0-B nrPDB 30 1.6 5E35-B nrPDB 30 1.7 5W5U-B nrPDB 30 1.9 6N41-A nrPDB 30 2.2 1Y0Y-A nrPDB 30 2.2 6HJN-B nrPDB 30 2.3 3TFC-A nrPDB 30 2.4 6MYA-A nrPDB 30 2.7 4HFU-B nrPDB 30 2.7 6A0Z-A nrPDB 30 2.9 2WR0-A nrPDB 30 3.4 2WR7-A nrPDB 29 3.8 2WRH-I nrPDB 29 4.4 4CZY-B nrPDB 29 4.8 4LVH-A nrPDB 29 5.3 4F3Z-B nrPDB 28 6.6 3JB8-A nrPDB 28 7.3 2ROG-A nrPDB 28 7.9 6ICZ-o nrPDB 28 8.6 >4CZT-A nrPDB Length = 464 Score = 947 bits (2448), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/459 (100%), Positives = 459/459 (100%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM Sbjct: 6 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 65 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD Sbjct: 66 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERR 323 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERR Sbjct: 246 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERR 305 Query: 324 EEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAP 383 EEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAP Sbjct: 306 EEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAP 365 Query: 384 MGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNL 443 MGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNL Sbjct: 366 MGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNL 425 Query: 444 TTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST 482 TTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST Sbjct: 426 TTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST 464 >4D28-A nrPDB Length = 446 Score = 563 bits (1452), Expect = e-161, Method: Compositional matrix adjust. Identities = 264/432 (61%), Positives = 339/432 (78%), Gaps = 7/432 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 RVGKYE+GRT+GEGTFAKVKFARN + GDNVAIK++ K +LKN+M+ QIKREIS MK++ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 +HPN++R++EV+ASK+KIY VLEFVTGGELFD+I GRLKEDE+RKYFQQL++AV +CH Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 S+GVYHRDLKPENLLLD NG LKVSDFGLSALPQ+ E LL+ TCGTPNYVAPEV++ + Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE--LLNDTCGTPNYVAPEVLSGQ 184 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 GYDG+ AD+WSCGVILFV++AGYLPF +++L LY+KI AEF CPPWFSA K LI RI Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRI 244 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKF-ENADVSLDDVDAIFDD-SGESKNLVVERRE 324 LDPNP TRI + ++ WF+K Y + E +V+LDD+ A+FD G VER + Sbjct: 245 LDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERND 304 Query: 325 EGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPM 384 EG P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A M Sbjct: 305 EG---PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 Query: 385 GFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLT 444 GF T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L Sbjct: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLC 421 Query: 445 TGLKDIVWKTID 456 + L++I+W+ + Sbjct: 422 SKLENIIWRATE 433 >5EZV-A nrPDB Length = 560 Score = 279 bits (713), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 128/289 (44%), Positives = 196/289 (67%), Gaps = 8/289 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI + Sbjct: 23 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 82 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++AVD Sbjct: 83 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY APEV Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEV 198 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 199 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 258 Query: 263 IKRILDPNPATRITFAEVIENEWFKK---GYKAPKFENADVSLDDVDAI 308 + +L +P R T ++ E+EWFK+ Y P+ + D ++ D +A+ Sbjct: 259 LMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 307 >4CFF-A nrPDB Length = 571 Score = 278 bits (712), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 128/289 (44%), Positives = 196/289 (67%), Gaps = 8/289 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI + Sbjct: 28 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 87 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++AVD Sbjct: 88 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY APEV Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEV 203 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 204 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 263 Query: 263 IKRILDPNPATRITFAEVIENEWFKK---GYKAPKFENADVSLDDVDAI 308 + +L +P R T ++ E+EWFK+ Y P+ + D ++ D +A+ Sbjct: 264 LMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 312 >2YZA-A nrPDB Length = 276 Score = 275 bits (702), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 124/271 (45%), Positives = 186/271 (68%), Gaps = 5/271 (1%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 GS GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKR Sbjct: 1 GSKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 60 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 EI +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+ Sbjct: 61 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 120 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNY 197 ++AVDYCH V HRDLKPEN+LLDA+ K++DFGLS + DG L +CG+PNY Sbjct: 121 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRDSCGSPNY 176 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 APEVI+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + Sbjct: 177 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR 236 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKK 288 S L+ +L +P R T ++ E+EWFK+ Sbjct: 237 SVATLLMHMLQVDPLKRATIKDIREHEWFKQ 267 >4CFH-A nrPDB Length = 493 Score = 273 bits (698), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 124/273 (45%), Positives = 188/273 (68%), Gaps = 7/273 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 GR ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI + Sbjct: 28 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 87 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ VD Sbjct: 88 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY APEV Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM----MSDGEFLRTSCGSPNYAAPEV 203 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 204 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL 263 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +K +L +P R T ++ E+EWFK+ PK+ Sbjct: 264 LKHMLQVDPMKRATIKDIREHEWFKQD--LPKY 294 >4REW-A nrPDB Length = 540 Score = 271 bits (692), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 122/273 (44%), Positives = 187/273 (68%), Gaps = 7/273 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI + Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ VD Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY APEV Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEV 176 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 177 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL 236 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +K +L +P R + ++ E+EWFK+ PK+ Sbjct: 237 LKHMLQVDPMKRASIKDIREHEWFKQD--LPKY 267 >4RED-A nrPDB Length = 351 Score = 268 bits (686), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 122/273 (44%), Positives = 187/273 (68%), Gaps = 7/273 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI + Sbjct: 9 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNL 68 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ VD Sbjct: 69 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY APEV Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAPEV 184 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 185 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL 244 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +K +L +P R + ++ E+EWFK+ PK+ Sbjct: 245 LKHMLQVDPMKRASIKDIREHEWFKQ--DLPKY 275 >3MN3-A nrPDB Length = 271 Score = 265 bits (677), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 122/263 (46%), Positives = 184/263 (69%), Gaps = 6/263 (2%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 +G Y++ +TLGEG+F KVK A + G VA+K+I+K+ + K+ M +I+REIS ++L Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 60 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 ++HP++I++++V+ SK +I V+E+ G ELFD I ++ E EAR++FQQ+I+AV+YC Sbjct: 61 LRHPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEVIN 204 H + HRDLKPENLLLD + +K++DFGLS + DG L T+CG+PNY APEVI+ Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLS----NIMTDGNFLKTSCGSPNYAAPEVIS 175 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 K Y G + D+WSCGVIL+V++ LPF+D ++ L+K I +T P + S A LIK Sbjct: 176 GKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIK 235 Query: 265 RILDPNPATRITFAEVIENEWFK 287 R+L NP RI+ E+++++WFK Sbjct: 236 RMLIVNPLNRISIHEIMQDDWFK 258 >3H4J-B nrPDB Length = 336 Score = 258 bits (659), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 117/264 (44%), Positives = 178/264 (67%), Gaps = 6/264 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 + +G Y + TLGEG+F KVK A + + VA+K I ++ + K+ M +++REIS + Sbjct: 4 SKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYL 63 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL++HP++I++++V+ + T I V+E+ GGELFD I R+ EDE R++FQQ+I A++ Sbjct: 64 KLLRHPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIICAIE 122 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEV 202 YCH + HRDLKPENLLLD N +K++DFGLS + DG L T+CG+PNY APEV Sbjct: 123 YCHRHKIVHRDLKPENLLLDDNLNVKIADFGLS----NIMTDGNFLKTSCGSPNYAAPEV 178 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 IN K Y G + D+WSCG++L+V++ G LPF+D + +L+KK+ + P + S A+ L Sbjct: 179 INGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSL 238 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I+R++ +P RIT E+ + WF Sbjct: 239 IRRMIVADPMQRITIQEIRRDPWF 262 >4YNZ-A nrPDB Length = 342 Score = 254 bits (648), Expect = 7e-68, Method: Compositional matrix adjust. Identities = 126/302 (41%), Positives = 191/302 (63%), Gaps = 13/302 (4%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G VG Y L +TLG+G VK + VAIK++++EK L ++ +++REI+ Sbjct: 4 GSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREK-LSESVLMKVEREIAI 62 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +KLI+HP+V+++ +V +K +Y VLE V+GGELFD + GRL EARK+F+Q+I+A+ Sbjct: 63 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 122 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 D+CHS + HRDLKPENLLLD ++++DFG+++L QV D LL T+CG+P+Y PEV Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNNIRIADFGMASL--QV-GDSLLETSCGSPHYACPEV 179 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I + YDG KAD+WSCGVILF L+ G LPF+D NL L +K+ + F P + + L Sbjct: 180 IRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSL 239 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN---------ADVSLDDVDAIFDDSG 313 ++ +++ + A R+T + ++ W+ G P+ E + SL+D+D DS Sbjct: 240 LRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSM 299 Query: 314 ES 315 S Sbjct: 300 HS 301 >5ES1-A nrPDB Length = 328 Score = 250 bits (639), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 113/266 (42%), Positives = 175/266 (65%), Gaps = 4/266 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 VG Y L RT+G+G FAKVK AR++ G VAIK+IDK + L + ++ RE+ MK + Sbjct: 13 HVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPSSLQKLFREVRIMKGL 71 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 HPN++++FEV+ ++ +Y V+E+ + GE+FD + S+GR+KE EAR F+Q+++AV YCH Sbjct: 72 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 131 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + + HRDLK ENLLLDA +K++DFG S + L T CG+P Y APE+ K Sbjct: 132 QKNIVHRDLKAENLLLDAEANIKIADFGFS---NEFTLGSKLDTFCGSPPYAAPELFQGK 188 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S + +++R Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRF 248 Query: 267 LDPNPATRITFAEVIENEWFKKGYKA 292 L NPA R T ++++++W GY+ Sbjct: 249 LVLNPAKRCTLEQIMKDKWINIGYEG 274 >2QNJ-A nrPDB Length = 328 Score = 250 bits (638), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 112/270 (41%), Positives = 179/270 (66%), Gaps = 4/270 (1%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S + +G Y L +T+G+G FAKVK AR++ G VAIK+IDK + L + ++ RE+ Sbjct: 5 SDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVR 63 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 MK++ HPN++++FEV+ ++ +Y ++E+ +GGE+FD + ++GR+KE EAR F+Q+++A Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSA 123 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 V YCH + + HRDLK ENLLLDA+ +K++DFG S + G L T CG+P Y APE Sbjct: 124 VQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPE 180 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 + K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S + Sbjct: 181 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 240 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYK 291 L+KR L NP R T +++++ W G++ Sbjct: 241 LLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270 >4CQG-A nrPDB Length = 331 Score = 249 bits (636), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 117/263 (44%), Positives = 174/263 (66%), Gaps = 3/263 (1%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YEL T+G G FAKVK A +V G+ VAIK++DK + + + ++K EI +K ++H + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD--LPRVKTEIDALKSLRHQH 68 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 + +++ V+ +K KI+ VLE+ GGELFD I S RL E+E R F+Q+++AV Y HS+G Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGY 128 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRDLKPENLL D N LK+ DFGL A P+ +D L CG+ Y APE+I K Y G Sbjct: 129 AHRDLKPENLLFDENHKLKLIDFGLCAKPKG-NKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPN 270 ++AD+WS G++L+VLM G+LPF+D N+ +LYKKI + ++ P W S S+ L++++L + Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVD 247 Query: 271 PATRITFAEVIENEWFKKGYKAP 293 P RI+ ++ + W + Y P Sbjct: 248 PKKRISMRNLLNHPWVMQDYSCP 270 >5KZ7-A nrPDB Length = 346 Score = 249 bits (635), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 111/274 (40%), Positives = 183/274 (66%), Gaps = 4/274 (1%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S +S+ + +G Y L +T+G+G FAKVK AR++ G VA+K+IDK + L + + ++ Sbjct: 22 SATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNSSSLQKLF 80 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 RE+ MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q Sbjct: 81 REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 140 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +++AV YCH + + HRDLK ENLLLDA+ +K++DFG S + L T CG+P Y Sbjct: 141 IVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPY 197 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 APE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 198 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST 257 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + L+K+ L NP+ R T +++++ W G++ Sbjct: 258 DCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHE 291 >4D2V-A nrPDB Length = 356 Score = 239 bits (609), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 123/306 (40%), Positives = 185/306 (60%), Gaps = 8/306 (2%) Query: 16 TPSGSSSGGRTRVGKY-ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 P GS + KY EL T+G G FAKVK A ++ G+ VAIK++DK + + + Sbjct: 15 VPRGSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD--LP 72 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 +IK EI +K ++H ++ +++ V+ + KI+ VLE+ GGELFD I S RL E+E R Sbjct: 73 RIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVV 132 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 F+Q+++AV Y HS+G HRDLKPENLL D LK+ DFGL A P+ +D L CG Sbjct: 133 FRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKG-NKDYHLQACCGA 191 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW 254 Y APE+I K Y G++AD+WS G++L+VLM G+LPF+D +L KI + ++ P W Sbjct: 192 LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKW 251 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP---KFENADVSLDDVDAIFDD 311 S S+ L++++L +P RI+ ++ + W + Y P + +N + LDD D + + Sbjct: 252 LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDD-DCVTEL 310 Query: 312 SGESKN 317 S +N Sbjct: 311 SVHHRN 316 >2HAK-A nrPDB Length = 328 Score = 233 bits (593), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 109/272 (40%), Positives = 180/272 (66%), Gaps = 4/272 (1%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S++ + +G Y L +T+G+G FAKVK AR+V G VA+K+IDK + L + ++ RE Sbjct: 6 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFRE 64 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q++ Sbjct: 65 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 124 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +AV YCH + + HRDLK ENLLLD + +K++DFG S + L T CG+P Y A Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDTFCGSPPYAA 181 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 182 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 241 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + L+K++L NP R + +++++ W G++ Sbjct: 242 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHE 273 >6C9D-A nrPDB Length = 459 Score = 231 bits (589), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 108/272 (39%), Positives = 179/272 (65%), Gaps = 4/272 (1%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S++ + +G Y L +T+G+G FAKVK AR+V G VA+K+IDK + L + ++ RE Sbjct: 12 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFRE 70 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q++ Sbjct: 71 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 130 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +AV YCH + + HRDLK ENLLLD + +K++DFG S + L CG+P Y A Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDEFCGSPPYAA 187 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 188 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 247 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + L+K++L NP R + +++++ W G++ Sbjct: 248 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHE 279 >5WAX-A nrPDB Length = 310 Score = 226 bits (577), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 121/285 (42%), Positives = 171/285 (60%), Gaps = 25/285 (8%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK-EKVLKNKMIAQIKREISTMKLIKH 88 +YEL R +G G F + RN +G VA+K I++ EK+ +N ++REI + ++H Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDEN-----VQREIINHRSLRH 66 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+IR EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V YCHS Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 149 GVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEV 202 V HRDLK EN LLD + A LK+ DFG S + +LH +T GTP Y+APEV Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEV 179 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDS----NLTSLYKKIFKAEFTCPPW--FS 256 + K YDG AD+WSCGV L+V++ G PFED N ++I +++ P + S Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHIS 239 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS 301 + LI RI NPATRIT E+ + WF K A +++ +S Sbjct: 240 PECQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMS 284 >5YKS-A nrPDB Length = 377 Score = 217 bits (553), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 116/298 (38%), Positives = 177/298 (59%), Gaps = 14/298 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G Y+L +TLG G FA VK AR+V G+ VA+KVIDK K L + +E+ MKL++H Sbjct: 35 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQH 93 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHS 147 PN++R++EV+ ++TK+Y +LE GG++FD I + L ED A+KYF Q+++A+ YCH Sbjct: 94 PNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 148 RGVYHRDLKPENLLL-DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 V HRDLKPEN++ + G +K++DFG S Q ++ L T+CG+ Y APE++ Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK---LTTSCGSLAYSAPEILLGD 210 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 YD D+WS GVILF+L+ G PF+++N + I ++T P S K LI R+ Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRM 270 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAP--KFENADVSLDDVDAIFDDSGESKNLVVER 322 L +P R + E+ + W + +P K+ VS ++ S E N +++R Sbjct: 271 LQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNL------SEEEHNSIIQR 322 >3ZUT-A nrPDB Length = 362 Score = 214 bits (544), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 113/276 (40%), Positives = 164/276 (59%), Gaps = 25/276 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK-EKVLKNKMIAQIKREISTMKLIKH 88 +YEL + +G G F + R+ ++ + VA+K I++ EK+ +N +KREI + ++H Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN-----VKREIINHRSLRH 74 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V YCH+ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 149 GVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEV 202 V HRDLK EN LLD + A LK+ FG S + +LH +T GTP Y+APEV Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYS-------KSSVLHSQPKSTVGTPAYIAPEV 187 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDS----NLTSLYKKIFKAEFTCPPW--FS 256 + K YDG AD+WSCGV L+V++ G PFED N +I ++ P + S Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + LI RI +PA RI+ E+ +EWF K A Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 >3UDB-A nrPDB Length = 317 Score = 210 bits (535), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 112/276 (40%), Positives = 163/276 (59%), Gaps = 25/276 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK-EKVLKNKMIAQIKREISTMKLIKH 88 +YEL + +G G F + R+ + + VA+K I++ EK+ +N +KREI + ++H Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDEN-----VKREIINHRSLRH 74 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V Y H+ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 149 GVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEV 202 V HRDLK EN LLD + A LK++DFG S + +LH + GTP Y+APEV Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYS-------KASVLHSQPKSAVGTPAYIAPEV 187 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDS----NLTSLYKKIFKAEFTCPPW--FS 256 + K YDG AD+WSCGV L+V++ G PFED N +I ++ P + S Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + LI RI +PA RI+ E+ +EWF K A Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPA 283 >3D2K-A nrPDB Length = 272 Score = 202 bits (515), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 97/263 (36%), Positives = 152/263 (57%), Gaps = 5/263 (1%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++GR LG+G F V AR ++ +A+KV+ K ++ K + Q++RE+ ++HPN Sbjct: 14 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPN 73 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R++ T++Y +LE+ G ++ ++ R E Y +L NA+ YCHS+ V Sbjct: 74 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRV 133 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+KPENLLL +NG LK++DFG S R T CGT +Y+ PE+I + +D Sbjct: 134 IHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGRMHD- 188 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPN 270 K DLWS GV+ + + G PFE Y++I + EFT P + + A+ LI R+L N Sbjct: 189 EKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHN 248 Query: 271 PATRITFAEVIENEWFKKGYKAP 293 + R+T AEV+E+ W K P Sbjct: 249 ASQRLTLAEVLEHPWIKANSSKP 271 >3UC3-A nrPDB Length = 361 Score = 202 bits (513), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 105/275 (38%), Positives = 158/275 (57%), Gaps = 23/275 (8%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ + +G G F + R+ + VA+K I++ + ++REI + ++HP Sbjct: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDEN----VQREIINHRSLRHP 76 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++R EV+ + T + ++E+ +GGEL+++I + GR EDEAR +FQQL++ V YCHS Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 Query: 150 VYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEVI 203 + HRDLK EN LLD + A LK+ DFG S + +LH +T GTP Y+APEV+ Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKK----IFKAEFTCPP--WFSA 257 + YDG AD+WSCGV L+V++ G PFED Y+K I +++ P S Sbjct: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 LI RI +PATRI+ E+ + WF K A Sbjct: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 >4B8L-A nrPDB Length = 286 Score = 200 bits (509), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 93/260 (35%), Positives = 151/260 (58%), Gaps = 5/260 (1%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + +++GR LG+G F V AR +N +A+KV+ K ++ K + Q++REI ++ Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++RM+ + +IY +LEF GEL+ ++ +GR E + + ++L +A+ YCH Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHE 133 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 R V HRD+KPENLL+ G LK++DFG S +R T CGT +Y+ PE+I K Sbjct: 134 RKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRR----RTMCGTLDYLPPEMIEGKT 189 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 +D K DLW GV+ + + G PF+ + T +++I + PP+ S +K LI ++L Sbjct: 190 HD-EKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLL 248 Query: 268 DPNPATRITFAEVIENEWFK 287 +P R+ V+E+ W K Sbjct: 249 RYHPPQRLPLKGVMEHPWVK 268 >4UZD-A nrPDB Length = 287 Score = 195 bits (496), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 95/263 (36%), Positives = 149/263 (56%), Gaps = 5/263 (1%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+GR LG+G F V AR ++ +A+KV+ K ++ K + Q++RE+ ++HPN Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R++ T++Y +LE+ G ++ ++ + E Y +L NA+ YCHS+ V Sbjct: 70 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 129 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+KPENLLL + G LK++DFG S R T CGT +Y+ PE+I + +D Sbjct: 130 IHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT----TLCGTLDYLPPEMIEGRMHD- 184 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPN 270 K DLWS GV+ + + G PFE + YK+I + EFT P + + A+ LI R+L N Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHN 244 Query: 271 PATRITFAEVIENEWFKKGYKAP 293 P+ R EV+E+ W P Sbjct: 245 PSQRPMLREVLEHPWITANSSKP 267 >4FG9-A nrPDB Length = 320 Score = 193 bits (490), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 107/265 (40%), Positives = 154/265 (58%), Gaps = 17/265 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+ LG G F++V A + VAIK I KE L+ K ++ EI+ + IKHPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKE-ALEGKE-GSMENEIAVLHKIKHPN 77 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ + ++ S +Y +++ V+GGELFD+I G E +A + Q+++AV Y H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 151 YHRDLKPENLL---LDANGALKVSDFGLSALPQQVRED--GLLHTTCGTPNYVAPEVINN 205 HRDLKPENLL LD + + +SDFGLS + ED +L T CGTP YVAPEV+ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKM-----EDPGSVLSTACGTPGYVAPEVLAQ 192 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 K Y A D WS GVI ++L+ GY PF D N L+++I KA EF P W S SAK Sbjct: 193 KPYSKA-VDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKD 251 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 I+ +++ +P R T + +++ W Sbjct: 252 FIRHLMEKDPEKRFTCEQALQHPWI 276 >1FOT-A nrPDB Length = 318 Score = 192 bits (489), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 156/263 (59%), Gaps = 11/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ RTLG G+F +V R+ NG A+KV+ KE V++ K + E + ++ HP Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +IRM+ +I+ +++++ GGELF + + R A+ Y ++ A++Y HS+ + Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDI 127 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 +RDLKPEN+LLD NG +K++DFG + V +T CGTP+Y+APEV++ K Y+ Sbjct: 128 IYRDLKPENILLDKNGHIKITDFGFAKYVPDVT-----YTLCGTPDYIAPEVVSTKPYNK 182 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPN 270 + D WS G++++ ++AGY PF DSN Y+KI AE PP+F+ K L+ R++ + Sbjct: 183 S-IDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRD 241 Query: 271 PATRI-----TFAEVIENEWFKK 288 + R+ +V + WFK+ Sbjct: 242 LSQRLGNLQNGTEDVKNHPWFKE 264 >5IG1-A nrPDB Length = 344 Score = 192 bits (488), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 99/260 (38%), Positives = 154/260 (59%), Gaps = 12/260 (4%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +G+G F+ V N G+ A+KVI K L++ I +IKREI ++H +++ M Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVI-ALKSLRSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 ++ Y V E+V+GGELFD+I + E +A Q+++A+ +CHS+ + HRDL Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 156 KPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 KPENLLL D N +K++DFGL+ + +Q GTP Y++PEVI YD A Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQ---GPTYFGFAGTPGYLSPEVIRRVPYDTA- 198 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI--FKAEFTCPPW--FSASAKKLIKRILD 268 D+W+CGVIL++L+ GY PF + + LY +I + +F P W + +AK+LIK +L+ Sbjct: 199 VDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLE 258 Query: 269 PNPATRITFAEVIENEWFKK 288 PNP R T E++++ W + Sbjct: 259 PNPKRRPTVQELLQHPWIAR 278 >2JC6-A nrPDB Length = 334 Score = 191 bits (484), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 105/263 (39%), Positives = 151/263 (57%), Gaps = 13/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E TLG G F++V A G A+K I K K LK K + I+ EI+ ++ IKH N Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPK-KALKGKE-SSIENEIAVLRKIKHEN 81 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ + ++ S +Y V++ V+GGELFD+I G E +A +Q+++AV Y H G+ Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 151 YHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLL D + +SDFGLS + + ++ T CGTP YVAPEV+ K Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGK---GDVMSTACGTPGYVAPEVLAQKP 198 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKKLI 263 Y A D WS GVI ++L+ GY PF D N + L+++I KA EF P W S SAK I Sbjct: 199 YSKA-VDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFI 257 Query: 264 KRILDPNPATRITFAEVIENEWF 286 + +++ +P R T + + W Sbjct: 258 RNLMEKDPNKRYTCEQAARHPWI 280 >5JZN-A nrPDB Length = 280 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 103/266 (38%), Positives = 157/266 (59%), Gaps = 18/266 (6%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y++GRT+G+G FA VK A+K+I K K + + I+ E+S ++ +KHP Sbjct: 20 RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKHP 77 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++ + E M T++Y V+E V GG+LFD I+S + E +A L +A+ Y HS Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 150 VYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRD+KPENLL+ D + +LK+ DFGL+ + DG L+T CGTP YVAPE+I Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-----DGPLYTVCGTPTYVAPEIIAE 192 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDS--NLTSLYKKIF--KAEFTCPPW--FSASA 259 GY G K D+W+ GVI ++L+ G+ PF S + L+ +I + +F P W S SA Sbjct: 193 TGY-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSA 251 Query: 260 KKLIKRILDPNPATRITFAEVIENEW 285 K+LI +L + R + +V+E+ W Sbjct: 252 KELITMMLLVDVDQRFSAVQVLEHPW 277 >2BRG-A nrPDB Length = 297 Score = 187 bits (475), Expect = 8e-48, Method: Compositional matrix adjust. Identities = 99/281 (35%), Positives = 162/281 (57%), Gaps = 9/281 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 V ++L +TLGEG + +V+ A N + VA+K++D ++ + IK+EI K++ Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP--ENIKKEICINKMLN 63 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NV++ + Y LE+ +GGELFD+I + + E +A+++F QL+ V Y H Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 G+ HRD+KPENLLLD LK+SDFGL+ + + + LL+ CGT YVAPE++ + Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLYKKIFKAEFTCPPW--FSASAKKLIK 264 + D+WSCG++L ++AG LP++ S+ Y + + PW ++ L+ Sbjct: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243 Query: 265 RILDPNPATRITFAEVIENEWF----KKGYKAPKFENADVS 301 +IL NP+ RIT ++ ++ W+ KKG K P+ + VS Sbjct: 244 KILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVS 284 >5U6Y-A nrPDB Length = 461 Score = 187 bits (474), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 103/264 (39%), Positives = 155/264 (58%), Gaps = 13/264 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L LG+G F+ V+ V G A K+I+ +K L + +++RE +L+KHPN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 60 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH GV Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAI--EVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y G DLW+CGVIL++L+ GY PF D + LY++I KA +F P W + AK L Sbjct: 179 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-KAGAYDFPSPEWDTVTPEAKDL 236 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I ++L NP+ RIT AE +++ W Sbjct: 237 INKMLTINPSKRITAAEALKHPWI 260 >2VZ6-A nrPDB Length = 313 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 103/264 (39%), Positives = 155/264 (58%), Gaps = 13/264 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L LG+G F+ V+ V G A K+I+ +K L + +++RE +L+KHPN Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 82 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH GV Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAI--EVEGEQQAWFGFAGTPGYLSPEVLRKDP 200 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y G DLW+CGVIL++L+ GY PF D + LY++I KA +F P W + AK L Sbjct: 201 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-KAGAYDFPSPEWDTVTPEAKDL 258 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I ++L NP+ RIT AE +++ W Sbjct: 259 INKMLTINPSKRITAAEALKHPWI 282 >2VN9-A nrPDB Length = 301 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 13/265 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+L LG+G F+ V+ + G A K+I+ +K L + +++RE +L+KHP Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHP 63 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++R+ + ++ + Y V + VTGGELF+ I + E +A QQ++ +V++CH G Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 123 Query: 150 VYHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLL + A+K++DFGL+ Q ++ GTP Y++PEV+ Sbjct: 124 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWF--GFAGTPGYLSPEVLRKD 181 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKK 261 Y G D+W+CGVIL++L+ GY PF D + LY++I KA +F P W + AK Sbjct: 182 PY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI-KAGAYDFPSPEWDTVTPEAKD 239 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NPA RIT +E +++ W Sbjct: 240 LINKMLTINPAKRITASEALKHPWI 264 >2JAM-A nrPDB Length = 304 Score = 184 bits (466), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 99/257 (38%), Positives = 147/257 (57%), Gaps = 15/257 (5%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG G F++V + G A+K I K ++ + ++ EI+ +K IKH N++ + Sbjct: 16 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD---SSLENEIAVLKKIKHENIVTLE 72 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 ++ S T Y V++ V+GGELFD+I G E +A QQ+++AV Y H G+ HRDL Sbjct: 73 DIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 132 Query: 156 KPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 KPENLL + N + ++DFGLS + Q +G++ T CGTP YVAPEV+ K Y A Sbjct: 133 KPENLLYLTPEENSKIMITDFGLSKMEQ----NGIMSTACGTPGYVAPEVLAQKPYSKA- 187 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKKLIKRILD 268 D WS GVI ++L+ GY PF + + L++KI + EF P W S SAK I +L+ Sbjct: 188 VDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLE 247 Query: 269 PNPATRITFAEVIENEW 285 +P R T + + + W Sbjct: 248 KDPNERYTCEKALSHPW 264 >3SOA-A nrPDB Length = 444 Score = 182 bits (462), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 101/265 (38%), Positives = 155/265 (58%), Gaps = 13/265 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+L LG+G F+ V+ V G A +I+ +K L + +++RE +L+KHP Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKK-LSARDHQKLEREARICRLLKHP 70 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH G Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 130 Query: 150 VYHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 V HR+LKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 131 VVHRNLKPENLLLASKLKGAAVKLADFGLAI--EVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKK 261 Y G DLW+CGVIL++L+ GY PF D + LY++I KA +F P W + AK Sbjct: 189 PY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-KAGAYDFPSPEWDTVTPEAKD 246 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NP+ RIT AE +++ W Sbjct: 247 LINKMLTINPSKRITAAEALKHPWI 271 >3F3Z-A nrPDB Length = 277 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 103/267 (38%), Positives = 156/267 (58%), Gaps = 19/267 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y L T+G G++ +VK A V+ G + A K I K V + + + K+EI MK + H Sbjct: 11 YTLENTIGRGSWGEVKIA--VQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDH 65 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+IR++E T IY V+E TGGELF+++ +E +A + + +++AV YCH Sbjct: 66 PNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKL 125 Query: 149 GVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 V HRDLKPEN L + LK+ DFGL+A + + ++ T GTP YV+P+V+ Sbjct: 126 NVAHRDLKPENFLFLTDSPDSPLKLIDFGLAA---RFKPGKMMRTKVGTPYYVSPQVL-- 180 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--WFSAS--AKK 261 +G G + D WS GV+++VL+ GY PF + + KI + FT P W + S A+ Sbjct: 181 EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAES 240 Query: 262 LIKRILDPNPATRITFAEVIENEWFKK 288 LI+R+L +P RIT + +E+EWF+K Sbjct: 241 LIRRLLTKSPKQRITSLQALEHEWFEK 267 >5JN2-A nrPDB Length = 525 Score = 181 bits (459), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 100/282 (35%), Positives = 162/282 (57%), Gaps = 18/282 (6%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ R LG+G+F +V ++ G A+KVI K +V + + RE+ +K + HP Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 127 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 128 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 187 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLL++ + +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 188 IVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK---MKDKIGTAYYIAPEVLHGT 244 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT--CPPW--FSASAKKL 262 YD K D+WS GVIL++L++G PF +N + KK+ K ++T P W S SAK L Sbjct: 245 -YD-EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDL 302 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYK------APKFENA 298 I+++L P+ RI+ + +++EW + K P +NA Sbjct: 303 IRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNA 344 >3BHH-A nrPDB Length = 295 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 156/264 (59%), Gaps = 13/264 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+L +G+G F+ V+ + G A K+I+ +K L + +++RE +L+KH Sbjct: 5 EYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLEREARICRLLKHS 63 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++R+ + ++ + Y V + VTGGELF+ I + E +A QQ++ AV +CH G Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 123 Query: 150 VYHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 V HRDLKPENLLL + A+K++DFGL+ Q ++ GTP Y++PEV+ + Sbjct: 124 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWF--GFAGTPGYLSPEVLRKE 181 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKK 261 Y G D+W+CGVIL++L+ GY PF D + LY++I KA +F P W + AK Sbjct: 182 AY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI-KAGAYDFPSPEWDTVTPEAKN 239 Query: 262 LIKRILDPNPATRITFAEVIENEW 285 LI ++L NPA RIT E +++ W Sbjct: 240 LINQMLTINPAKRITAHEALKHPW 263 >4I6B-A nrPDB Length = 308 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 90/272 (33%), Positives = 154/272 (56%), Gaps = 9/272 (3%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y G+TLG+G FAK ++ N A K+I +V K +I +EI +++ H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 +V++ + K IY +LE+ + + + + L E E R Y +Q+++ + Y H + Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH---TTCGTPNYVAPEVINNK 206 + HRDLK N ++ + LKV DFGL+A R + L H T CGTPNY++PEV+N + Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAA-----RLEPLEHRRRTICGTPNYLSPEVLNKQ 203 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 G+ GA++D+W+ G +++ ++ G PFE +NL Y+ I +A +T P A AK LI + Sbjct: 204 GH-GAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASM 262 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKFENA 298 L NP R + ++I +++F +G+ + ++ Sbjct: 263 LSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSS 294 >3NCG-A nrPDB Length = 486 Score = 177 bits (450), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 97/266 (36%), Positives = 153/266 (57%), Gaps = 13/266 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y + LG+G+F +V ++ A+KVI+K KNK + I RE+ +K + HP Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDHP 81 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++++FE++ + Y V E TGGELFD+I R E +A + +Q+ + + Y H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPEN+LL++ + +K+ DFGLS QQ + + GT Y+APEV+ + Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ---NTKMKDRIGTAYYIAPEVL--R 196 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPPW--FSASAKKL 262 G K D+WS GVIL++L++G PF N + K++ K F P W S AK L Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 263 IKRILDPNPATRITFAEVIENEWFKK 288 I+++L +P+ RIT + +E+ W +K Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >4JXF-A nrPDB Length = 266 Score = 177 bits (450), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 85/263 (32%), Positives = 151/263 (57%), Gaps = 4/263 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 ++ +++G LG+G+FA V A ++ G VAIK+IDK+ + K M+ +++ E+ + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYC 145 KHP+++ ++ +Y VLE GE+ + + + E+EAR + Q+I + Y Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS G+ HRDL NLLL N +K++DFGL+ + E +T CGTPNY++PE+ Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKH--YTLCGTPNYISPEIATR 182 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 + G ++D+WS G + + L+ G PF+ + + K+ A++ P + S AK LI + Sbjct: 183 SAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQ 241 Query: 266 ILDPNPATRITFAEVIENEWFKK 288 +L NPA R++ + V+++ + + Sbjct: 242 LLRRNPADRLSLSSVLDHPFMSR 264 >3MA6-A nrPDB Length = 298 Score = 177 bits (450), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 96/265 (36%), Positives = 157/265 (59%), Gaps = 12/265 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ R LG+G+F +V ++ G A+KVI K +V + + RE+ +K + HP Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHP 92 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 93 NIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 152 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLL++ + +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 153 IVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK---MKDKIGTAYYIAPEVLHGT 209 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT--CPPW--FSASAKKL 262 YD K D+WS GVIL++L++G PF +N + KK+ K ++T P W S SAK L Sbjct: 210 -YD-EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDL 267 Query: 263 IKRILDPNPATRITFAEVIENEWFK 287 I+++L P+ RI+ + +++EW + Sbjct: 268 IRKMLTYVPSMRISARDALDHEWIQ 292 >5X3F-B nrPDB Length = 393 Score = 177 bits (450), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 90/260 (34%), Positives = 151/260 (58%), Gaps = 10/260 (3%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 TPS +++ ++ +++ +TLG G+F +V ++ E+G++ A+K++DK+KV+K K I Sbjct: 75 TPSQNTA----QLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEH 130 Query: 76 IKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 E ++ + P ++++ + +Y V+E+V GGE+F + GR E AR Y Sbjct: 131 TLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYA 190 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q++ +Y HS + +RDLKPENLL+D G ++V+DFG + R G T CGTP Sbjct: 191 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWTLCGTP 245 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF 255 Y+APE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P F Sbjct: 246 EYLAPEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 304 Query: 256 SASAKKLIKRILDPNPATRI 275 S+ K L++ +L + R Sbjct: 305 SSDLKDLLRNLLQVDLTKRF 324 >4B6L-A nrPDB Length = 281 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 97/270 (35%), Positives = 148/270 (54%), Gaps = 13/270 (4%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 GRT Y GR LG+G FA+ A + E G A+KVI + +V K +I EI Sbjct: 8 GRT----YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH 63 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 + ++H +++R IY LE + L + L E E R Y +Q+++ + Sbjct: 64 RDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLK 123 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL---PQQVREDGLLHTTCGTPNYVAP 200 Y H RG+ HRDLK N + N LKV DFGL+A P+Q ++ T CGTPNYVAP Sbjct: 124 YLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKK-----TICGTPNYVAP 178 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 EV+ +G+ G +AD+WS G +++ L+ G PFE ++L Y+ I + +T P S A+ Sbjct: 179 EVLLRQGH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPAR 237 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGY 290 +L+ IL +P R + +++ +++F KGY Sbjct: 238 QLLAAILRASPRDRPSIDQILRHDFFTKGY 267 >4WB7-A nrPDB Length = 405 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 89/256 (34%), Positives = 145/256 (56%), Gaps = 6/256 (2%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S + + ++E +TLG G+F +V ++ E G++ A+K++DK+KV+K K I E Sbjct: 87 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 146 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 ++ + P ++++ + +Y V+E+V GGE+F + GR E AR Y Q++ Sbjct: 147 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 206 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +Y HS + +RDLKPENLL+D G ++V+DFG + R G T CGTP Y+A Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWTLCGTPEYLA 261 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ Sbjct: 262 PEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 320 Query: 260 KKLIKRILDPNPATRI 275 K L++ +L + R Sbjct: 321 KDLLRNLLQVDLTKRF 336 >5FG8-A nrPDB Length = 285 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 98/264 (37%), Positives = 151/264 (57%), Gaps = 13/264 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y++ LG+G F+ VK G A K+I+ +K L + +++RE + + HPN Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKK-LTARDFQKLEREARICRKLHHPN 74 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + + + Y V + VTGGELF+ I + E +A QQ++ +V++CH GV Sbjct: 75 IVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 134 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ Q + GTP Y++PEV+ + Sbjct: 135 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWF--GFAGTPGYLSPEVLKKEP 192 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y G D+W+CGVIL++L+ GY PF D + LY +I KA ++ P W + AK L Sbjct: 193 Y-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI-KAGAYDYPSPEWDTVTPEAKNL 250 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I ++L NP RIT AE +++ W Sbjct: 251 INQMLTVNPNKRITAAEALKHPWI 274 >3DFA-A nrPDB Length = 286 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 97/266 (36%), Positives = 153/266 (57%), Gaps = 13/266 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y + LG+G+F +V ++ A+KVI+K KNK + I RE+ +K + HP Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDHP 81 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++++FE++ + Y V E TGGELFD+I R E +A + +Q+ + + Y H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPEN+LL++ + +K+ DFGLS QQ + + GT Y+APEV+ + Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ---NTKMKDRIGTAYYIAPEVL--R 196 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPPW--FSASAKKL 262 G K D+WS GVIL++L++G PF N + K++ K F P W S AK L Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 263 IKRILDPNPATRITFAEVIENEWFKK 288 I+++L +P+ RIT + +E+ W +K Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >2BDW-A nrPDB Length = 362 Score = 174 bits (442), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 94/264 (35%), Positives = 151/264 (57%), Gaps = 14/264 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y++ LG+G F+ V+ + G A K+I+ +K L + +++RE + ++HPN Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQHPN 89 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + + ++ Y V + VTGGELF+ I + E +A QQ++ ++ YCHS G+ Sbjct: 90 IVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGI 149 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HR+LKPENLLL + A+K++DFGL+ +V + H GTP Y++PEV+ Sbjct: 150 VHRNLKPENLLLASKAKGAAVKLADFGLAI---EVNDSEAWHGFAGTPGYLSPEVLKKDP 206 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y D+W+CGVIL++L+ GY PF D + LY +I KA ++ P W + AK L Sbjct: 207 Y-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI-KAGAYDYPSPEWDTVTPEAKSL 264 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I +L NP RIT + ++ W Sbjct: 265 IDSMLTVNPKKRITADQALKVPWI 288 >3TXO-A nrPDB Length = 353 Score = 174 bits (441), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 88/258 (34%), Positives = 143/258 (55%), Gaps = 4/258 (1%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G +S R + +E R LG+G+F KV AR E GD A+KV+ K+ +L++ + Sbjct: 13 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 72 Query: 79 EISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E + L + HP + ++F + +++FV+EFV GG+L I + R E AR Y + Sbjct: 73 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 132 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +I+A+ + H +G+ +RDLK +N+LLD G K++DFG+ + + T CGTP+Y Sbjct: 133 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDY 190 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 +APE++ Y G D W+ GV+L+ ++ G+ PFE N L++ I E P W Sbjct: 191 IAPEILQEMLY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHE 249 Query: 258 SAKKLIKRILDPNPATRI 275 A ++K + NP R+ Sbjct: 250 DATGILKSFMTKNPTMRL 267 >5N23-A nrPDB Length = 352 Score = 173 bits (438), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 91/257 (35%), Positives = 143/257 (55%), Gaps = 7/257 (2%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S + + ++E RTLG G+F +V ++ E G++ A+K++DK+KV+K K I E Sbjct: 33 SPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + + P ++++ + +Y VLE+ GGE+F + GR E AR Y Q++ Sbjct: 93 KRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL-HTTCGTPNYV 198 +Y HS + +RDLKPENLL+D G +KV+DFG + R G T CGTP Y+ Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAK-----RVKGRTPWTLCGTPEYL 207 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS 258 APE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ Sbjct: 208 APEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 266 Query: 259 AKKLIKRILDPNPATRI 275 K L++ +L + R Sbjct: 267 LKDLLRNLLQVDLTKRF 283 >3KK8-A nrPDB Length = 284 Score = 173 bits (438), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 94/264 (35%), Positives = 151/264 (57%), Gaps = 14/264 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y++ LG+G F+ V+ + G A K+I+ +K L + +++RE + ++HPN Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQHPN 66 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + + ++ Y V + VTGGELF+ I + E +A QQ++ ++ YCHS G+ Sbjct: 67 IVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGI 126 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HR+LKPENLLL + A+K++DFGL+ +V + H GTP Y++PEV+ Sbjct: 127 VHRNLKPENLLLASKAKGAAVKLADFGLAI---EVNDSEAWHGFAGTPGYLSPEVLKKDP 183 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y D+W+CGVIL++L+ GY PF D + LY +I KA ++ P W + AK L Sbjct: 184 Y-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI-KAGAYDYPSPEWDTVTPEAKSL 241 Query: 263 IKRILDPNPATRITFAEVIENEWF 286 I +L NP RIT + ++ W Sbjct: 242 IDSMLTVNPKKRITADQALKVPWI 265 >2YCR-A nrPDB Length = 323 Score = 172 bits (436), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 105/284 (36%), Positives = 154/284 (54%), Gaps = 21/284 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-----KNKMIAQIKREISTMK 84 +Y + +TLG G +VK A + VAIK+I K K + ++ EI +K Sbjct: 11 EYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILK 70 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 + HP +I++ ++ Y VLE + GGELFDK+ N RLKE + YF Q++ AV Y Sbjct: 71 KLNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 129 Query: 145 CHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 H G+ HRDLKPEN+LL + + +K++DFG S + + E L+ T CGTP Y+APE Sbjct: 130 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPE 186 Query: 202 V---INNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFTCPP--WF 255 V + GY+ A D WS GVILF+ ++GY PF E SL +I ++ P W Sbjct: 187 VLVSVGTAGYNRA-VDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 256 SASAK--KLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 S K L+K++L +P R T E + + W + KF++ Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 289 >4RGJ-A nrPDB Length = 520 Score = 172 bits (435), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 97/266 (36%), Positives = 153/266 (57%), Gaps = 13/266 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ + LG+G+F +V +R+ G AIKVI K+ V + + RE+ +K++ H Sbjct: 61 QYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHI 120 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E Y V + TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 121 NIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNN 180 Query: 150 VYHRDLKPENLLLDANG----ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 V HRDLKPEN+LL+ +K+ DFGLS + ++ + GT Y+AP+V++ Sbjct: 181 VVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK---MKDKIGTAYYIAPDVLHG 237 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP-PWF---SASAKK 261 YD K D+WSCGVIL++L++G PF SN + KK+ ++T P F S AK Sbjct: 238 -TYD-EKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKD 295 Query: 262 LIKRILDPNPATRITFAEVIENEWFK 287 LIK++L A RI+ + +E+EW K Sbjct: 296 LIKKMLMYTSAVRISARDALEHEWIK 321 >4YZB-A nrPDB Length = 491 Score = 171 bits (434), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 100/267 (37%), Positives = 155/267 (58%), Gaps = 16/267 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ R LG+G+F +V ++ G A+KVI K +V + + +E+ +K + HP Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHP 90 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 91 NIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 150 Query: 150 VYHRDLKPENLLL-----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 + HRDLKPENLLL DAN +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 151 IVHRDLKPENLLLENKRKDAN--IRIIDFGLSTHFESTKK---MKDKIGTAYYIAPEVLH 205 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT--CPPW--FSASAK 260 YD K D+WS GVIL++L++G PF +N + KK+ K +FT P W S AK Sbjct: 206 GT-YD-EKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAK 263 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+++L P RI+ + +E+EW K Sbjct: 264 DLIRKMLAYVPTMRISARDALEHEWLK 290 >3HZT-A nrPDB Length = 467 Score = 171 bits (432), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 94/266 (35%), Positives = 145/266 (54%), Gaps = 12/266 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ + LG G + +V ++ G AIK+I K V + E++ +K + HP Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 64 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E K Y V+E GGELFD+I + E +A +Q+++ Y H Sbjct: 65 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHN 124 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLL++ + +K+ DFGLSA G + GT Y+APEV+ K Sbjct: 125 IVHRDLKPENLLLESKSRDALIKIVDFGLSA---HFEVGGKMKERLGTAYYIAPEVLRKK 181 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPWFSAS--AKKL 262 YD K D+WSCGVIL++L+ GY PF + K++ K +F+ P W S AK+L Sbjct: 182 -YD-EKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQL 239 Query: 263 IKRILDPNPATRITFAEVIENEWFKK 288 +K +L P+ RI+ E + + W K Sbjct: 240 VKLMLTYEPSKRISAEEALNHPWIVK 265 >4AF3-A nrPDB Length = 292 Score = 171 bits (432), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 89/260 (34%), Positives = 146/260 (56%), Gaps = 5/260 (1%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + +E+GR LG+G F V AR ++ VA+KV+ K ++ K + Q++REI + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++R++ + +IY +LE+ GEL+ ++ + E ++L +A+ YCH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + V HRD+KPENLLL G LK++DFG S +R T CGT +Y+ PE+I + Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRK----TMCGTLDYLPPEMIEGRM 197 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 ++ K DLW GV+ + L+ G PFE ++ Y++I K + P A+ LI ++L Sbjct: 198 HN-EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 268 DPNPATRITFAEVIENEWFK 287 NP+ R+ A+V + W + Sbjct: 257 RHNPSERLPLAQVSAHPWVR 276 >2W4O-A nrPDB Length = 349 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 96/279 (34%), Positives = 155/279 (55%), Gaps = 19/279 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+ LG G + V + A+KV+ +K + K++ + EI + + HPN Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVL--KKTVDKKIV---RTEIGVLLRLSHPN 109 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +I++ E+ + T+I VLE VTGGELFD+I G E +A +Q++ AV Y H G+ Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 151 YHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLL + LK++DFGLS + V L+ T CGTP Y APE++ Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKI---VEHQVLMKTVCGTPGYCAPEILRGCA 226 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTS-LYKKIFKAEFT-CPPWF---SASAKKL 262 Y G + D+WS G+I ++L+ G+ PF D ++++I E+ PW+ S +AK L Sbjct: 227 Y-GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 285 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS 301 +++++ +P R+T + +++ W KA F + D + Sbjct: 286 VRKLIVLDPKKRLTTFQALQHPWVTG--KAANFVHMDTA 322 >2V7O-A nrPDB Length = 336 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 96/263 (36%), Positives = 150/263 (57%), Gaps = 13/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L LG+G F+ V+ A K+I+ +K L + +++RE +L+KHPN Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 91 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + ++ + Y V + VTGGELF+ I + E +A Q++ +V++ H + Sbjct: 92 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDI 151 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ Q E GTP Y++PEV+ Sbjct: 152 VHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG--EQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPW--FSASAKKL 262 Y G D+W+CGVIL++L+ GY PF D + LY++I KA +F P W + AK L Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI-KAGAYDFPSPEWDTVTPEAKNL 267 Query: 263 IKRILDPNPATRITFAEVIENEW 285 I ++L NPA RIT + +++ W Sbjct: 268 INQMLTINPAKRITADQALKHPW 290 >3LIJ-A nrPDB Length = 494 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 99/282 (35%), Positives = 157/282 (55%), Gaps = 20/282 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+ + LG G + +V R+ AIK+I K V + +++ E++ +KL+ HPN Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN-SKLLEEVAVLKLLDHPN 97 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++++++ K Y V+E GGELFD+I + E +A +Q+++ V Y H + Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNI 157 Query: 151 YHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL++ + +K+ DFGLSA+ + ++ + GT Y+APEV+ K Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKK---MKERLGTAYYIAPEVLRKK- 213 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT--CPPW--FSASAKKLI 263 YD K D+WS GVILF+L+AGY PF + +K+ K ++T P W S AK LI Sbjct: 214 YD-EKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 264 KRILDPNPATRITFAEVIENEWFKK-------GYKAPKFENA 298 K++L + RI+ + +E+ W K+ G + P NA Sbjct: 273 KQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANA 314 >3DXN-A nrPDB Length = 287 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 94/266 (35%), Positives = 145/266 (54%), Gaps = 12/266 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y+ + LG G + +V ++ G AIK+I K V + E++ +K + HP Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 81 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E K Y V+E GGELFD+I + E +A +Q+++ Y H Sbjct: 82 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHN 141 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLL++ + +K+ DFGLSA G + GT Y+APEV+ K Sbjct: 142 IVHRDLKPENLLLESKSRDALIKIVDFGLSA---HFEVGGKMKERLGTAYYIAPEVLRKK 198 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPWFSAS--AKKL 262 YD K D+WSCGVIL++L+ GY PF + K++ K +F+ P W S AK+L Sbjct: 199 -YD-EKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQL 256 Query: 263 IKRILDPNPATRITFAEVIENEWFKK 288 +K +L P+ RI+ E + + W K Sbjct: 257 VKLMLTYEPSKRISAEEALNHPWIVK 282 >3I6U-A nrPDB Length = 419 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 104/284 (36%), Positives = 154/284 (54%), Gaps = 21/284 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL-----KNKMIAQIKREISTMK 84 +Y + +TLG G +VK A + VAI++I K K + ++ EI +K Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILK 195 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 + HP +I++ ++ Y VLE + GGELFDK+ N RLKE + YF Q++ AV Y Sbjct: 196 KLNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 254 Query: 145 CHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 H G+ HRDLKPEN+LL + + +K++DFG S + + E L+ T CGTP Y+APE Sbjct: 255 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPE 311 Query: 202 V---INNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFTCPP--WF 255 V + GY+ A D WS GVILF+ ++GY PF E SL +I ++ P W Sbjct: 312 VLVSVGTAGYNRA-VDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 256 SASAK--KLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 S K L+K++L +P R T E + + W + KF++ Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 414 >2Z7Q-A nrPDB Length = 321 Score = 169 bits (428), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 87/248 (35%), Positives = 147/248 (59%), Gaps = 7/248 (2%) Query: 31 YELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 +EL + LG+G+F KV R V ++G A+KV+ K+ LK + + K E + + Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILADVN 88 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HP V+++ ++ K+Y +L+F+ GG+LF ++S E++ + Y +L +D+ HS Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 148 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 G+ +RDLKPEN+LLD G +K++DFGLS + + + ++ CGT Y+APEV+N +G Sbjct: 149 LGIIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTVEYMAPEVVNRQG 206 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 + + AD WS GV++F ++ G LPF+ + I KA+ P + S A+ L++ + Sbjct: 207 HSHS-ADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 265 Query: 268 DPNPATRI 275 NPA R+ Sbjct: 266 KRNPANRL 273 >6CMJ-A nrPDB Length = 321 Score = 169 bits (427), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 95/282 (33%), Positives = 155/282 (54%), Gaps = 17/282 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK--------MIAQIK 77 ++ +Y L +G+G++ VK A N + A+KV+ K+K+++ I Q+ Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 78 REISTMKLIKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 +EI+ +K + HPNV+++ EV+ ++ +Y V E V G + + + + L ED+AR YF Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYF 149 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q LI ++Y H + + HRD+KP NLL+ +G +K++DFG+S + D LL T GTP Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN--EFKGSDALLSNTVGTP 207 Query: 196 NYVAPEVINN--KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTC 251 ++APE ++ K + G D+W+ GV L+ + G PF D + L+ KI EF Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 267 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 P + K LI R+LD NP +RI E+ + W + P Sbjct: 268 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 309 >5D9K-A nrPDB Length = 330 Score = 168 bits (426), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 147/249 (59%), Gaps = 7/249 (2%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 ++EL + LG+G+F KV + + D A+KV+ K+ LK + + K E + + Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVEV 89 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 HP ++++ ++ K+Y +L+F+ GG+LF ++S E++ + Y +L A+D+ H Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 149 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 S G+ +RDLKPEN+LLD G +K++DFGLS + + + ++ CGT Y+APEV+N + Sbjct: 150 SLGIIYRDLKPENILLDEEGHIKLTDFGLSK--ESIDHEKKAYSFCGTVEYMAPEVVNRR 207 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 G+ + AD WS GV++F ++ G LPF+ + I KA+ P + S A+ L++ + Sbjct: 208 GHTQS-ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRML 266 Query: 267 LDPNPATRI 275 NPA R+ Sbjct: 267 FKRNPANRL 275 >2J90-A nrPDB Length = 304 Score = 168 bits (426), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 94/268 (35%), Positives = 152/268 (56%), Gaps = 15/268 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 YE+G LG G FA V+ R G A K I K ++ ++ +I+RE++ ++ I+ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN+I + ++ +KT + +LE V+GGELFD ++ L EDEA ++ +Q+++ V Y HS Sbjct: 88 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 147 Query: 148 RGVYHRDLKPEN-LLLD---ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + + H DLKPEN +LLD N +K+ DFG++ ++ GTP +VAPE++ Sbjct: 148 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIA---HKIEAGNEFKNIFGTPEFVAPEIV 204 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC-PPWFSAS---A 259 N + G +AD+WS GVI ++L++G PF I + +FS + A Sbjct: 205 NYEPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELA 263 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK 287 K I+R+L +P R+T A+ +E+ W K Sbjct: 264 KDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >5YV8-A nrPDB Length = 298 Score = 168 bits (425), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 98/300 (32%), Positives = 158/300 (52%), Gaps = 32/300 (10%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK------ 71 S SSG ++ +Y L +G+G++ VK A N + A+KV+ K+K+++ Sbjct: 2 SSGSSGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRP 61 Query: 72 -----------------MIAQIKREISTMKLIKHPNVIRMFEVM--ASKTKIYFVLEFVT 112 I Q+ +EI+ +K + HPNV+++ EV+ ++ +Y V E V Sbjct: 62 PPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVN 121 Query: 113 GGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSD 172 G + + + + L ED+AR YFQ LI ++Y H + + HRD+KP NLL+ +G +K++D Sbjct: 122 QGPVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIAD 180 Query: 173 FGLSALPQQVREDGLLHTTCGTPNYVAPEVINN--KGYDGAKADLWSCGVILFVLMAGYL 230 FG+S + D LL T GTP ++APE ++ K + G D+W+ GV L+ + G Sbjct: 181 FGVSN--EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQC 238 Query: 231 PFEDSNLTSLYKKIFKA--EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 PF D + L+ KI EF P + K LI R+LD NP +RI E+ + W + Sbjct: 239 PFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >4L42-A nrPDB Length = 346 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 86/255 (33%), Positives = 146/255 (57%), Gaps = 7/255 (2%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKN-KMIAQIKREI 80 + R +EL R LG+G + KV R V G A+KV+ K +++N K A K E Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 + ++ +KHP ++ + + K+Y +LE+++GGELF ++ G ED A Y ++ Sbjct: 74 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 133 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 A+ + H +G+ +RDLKPEN++L+ G +K++DFGL + + + + HT CGT Y+AP Sbjct: 134 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK--ESIHDGTVTHTFCGTIEYMAP 191 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E++ G++ A D WS G +++ ++ G PF N KI K + PP+ + A+ Sbjct: 192 EILMRSGHNRA-VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 250 Query: 261 KLIKRILDPNPATRI 275 L+K++L N A+R+ Sbjct: 251 DLLKKLLKRNAASRL 265 >4RLP-A nrPDB Length = 288 Score = 166 bits (420), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 86/255 (33%), Positives = 146/255 (57%), Gaps = 7/255 (2%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKN-KMIAQIKREI 80 + R +EL R LG+G + KV R V G A+KV+ K +++N K A K E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 + ++ +KHP ++ + + K+Y +LE+++GGELF ++ G ED A Y ++ Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 A+ + H +G+ +RDLKPEN++L+ G +K++DFGL + + + + HT CGT Y+AP Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK--ESIHDGTVTHTFCGTIEYMAP 178 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E++ G++ A D WS G +++ ++ G PF N KI K + PP+ + A+ Sbjct: 179 EILMRSGHNRA-VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 237 Query: 261 KLIKRILDPNPATRI 275 L+K++L N A+R+ Sbjct: 238 DLLKKLLKRNAASRL 252 >3TAC-A nrPDB Length = 361 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 94/272 (34%), Positives = 152/272 (55%), Gaps = 19/272 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA--QIKREISTMKLIKH 88 YEL +G+G F+ V+ N E G A+K++D K + ++ +KRE S ++KH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLINAVDY 144 P+++ + E +S +Y V EF+ G +L +I E A Y +Q++ A+ Y Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 145 CHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLH-TTCGTPNYVAP 200 CH + HRD+KP +LL + + +K+ FG++ Q+ E GL+ GTP+++AP Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAI---QLGESGLVAGGRVGTPHFMAP 204 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--W--FS 256 EV+ + Y G D+W CGVILF+L++G LPF + L++ I K ++ P W S Sbjct: 205 EVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHIS 262 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 SAK L++R+L +PA RIT E + + W K+ Sbjct: 263 ESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >5XZW-A nrPDB Length = 471 Score = 165 bits (417), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 96/294 (32%), Positives = 160/294 (54%), Gaps = 29/294 (9%) Query: 16 TPSGSSSGGRTRVGKYE----LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK 71 T S +SS + G ++ + +G+G FA VK A G A+K+I K KV+ N Sbjct: 179 TSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGN- 237 Query: 72 MIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEA 131 + + RE+ ++ + HP ++R+ Y V+EFV+GG+L D ++++G + ED Sbjct: 238 -MDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG 296 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDG-LL 188 R+ +Q++ A+ Y HS G+ HRDLKP+N+L++ + +K++DFGL+ +V+ +G + Sbjct: 297 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLA----KVQGNGSFM 352 Query: 189 HTTCGTPNYVAPEVINNKG-------YD-----GAKADLWSCGVILFVLMAGYLPFEDSN 236 T CGT YVAPEVI K Y+ + D+WS G +++V++ G+LPF S Sbjct: 353 KTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST 412 Query: 237 LTSLYKKIFKAEFTCPPW----FSASAKKLIKRILDPNPATRITFAEVIENEWF 286 LYK+I + + P S A+ I +L +P R T A+ + + W Sbjct: 413 QDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >3KN6-A nrPDB Length = 325 Score = 164 bits (415), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 97/270 (35%), Positives = 155/270 (57%), Gaps = 24/270 (8%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIR 93 + LGEG+F+ + + ++ A+K+I K +M A ++EI+ +KL + HPN+++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + EV + + V+E + GGELF++I E EA ++L++AV + H GV HR Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 154 DLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 DLKPENLL + N +K+ DFG + L + ++ L T C T +Y APE++N GYD Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARL--KPPDNQPLKTPCFTLHYAAPELLNQNGYDE 188 Query: 211 AKADLWSCGVILFVLMAGYLPFE--DSNLTS-----LYKKIFKAEFTC--PPW--FSASA 259 + DLWS GVIL+ +++G +PF+ D +LT + KKI K +F+ W S A Sbjct: 189 S-CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 247 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKG 289 K LI+ +L +P R+ + + NEW + G Sbjct: 248 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDG 277 >3Q5I-A nrPDB Length = 504 Score = 164 bits (414), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 100/271 (36%), Positives = 144/271 (53%), Gaps = 22/271 (8%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK------NKMIA----QIKREISTMK 84 R LG G + +V + AIKVI K + K NK I +I EIS +K Sbjct: 42 RKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLK 101 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 + HPN+I++F+V K Y V EF GGELF++I + + E +A +Q+++ + Y Sbjct: 102 SLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICY 161 Query: 145 CHSRGVYHRDLKPENLLLDANGAL---KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 H + HRD+KPEN+LL+ +L K+ DFGLS+ +D L GT Y+APE Sbjct: 162 LHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSF---FSKDYKLRDRLGTAYYIAPE 218 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPPW--FSA 257 V+ K K D+WSCGVI+++L+ GY PF N + KK+ K + F W S Sbjct: 219 VLKKKY--NEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISD 276 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKK 288 AK+LIK +L + R T E + + W KK Sbjct: 277 EAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 >4PDS-A nrPDB Length = 347 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 90/274 (32%), Positives = 151/274 (55%), Gaps = 25/274 (9%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 + +G+G FA VK A G ++K+I K KV+ N + + RE+ ++ + HP ++ Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGN--MDGVTRELEVLQKLNHPRIV 92 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 R+ Y V+EFV+GG+L D ++++G + ED R+ +Q++ A+ Y HS G+ H Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 152 Query: 153 RDLKPENLLLDANGA--LKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEVINNKG-- 207 RDLKP+N+L++ + +K++ FGL+ +V+ +G + T CGT YVAPEVI K Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLA----KVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 208 Query: 208 -----YD-----GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW--- 254 Y+ + D+WS G +++V++ G+LPF S LYK+I + + P Sbjct: 209 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDF 268 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 S A+ I +L +P R T A+ + + W K Sbjct: 269 RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >2JDO-A nrPDB Length = 342 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 86/267 (32%), Positives = 145/267 (54%), Gaps = 8/267 (2%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + + ++ + LG+GTF KV R G A+K++ KE ++ +A E ++ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S E+ AR Y ++++A++Y Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HSR V +RD+K ENL+LD +G +K++DFGL + + + + T CGTP Y+APEV+ Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLE 183 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 + Y G D W GV+++ +M G LPF + + L++ I E P S AK L+ Sbjct: 184 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLA 242 Query: 265 RILDPNPATRI-----TFAEVIENEWF 286 +L +P R+ EV+E+ +F Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >4MVF-A nrPDB Length = 506 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 98/270 (36%), Positives = 145/270 (53%), Gaps = 15/270 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KY + LG+GT+ V + ++ N + I +EK + K I + +EI MK + HP Sbjct: 58 KYIIDEKLGQGTYGCV--YKGIDKVTN-QLYAIKEEKKDRLKNINRFFQEIEIMKKLDHP 114 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+++++E + IY ++E +G ELFD I NG E A +Q+ +A+ Y HS Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 150 VYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPEN L + + LK+ DFGLS + + T GTP YVAP+V++ K Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLS---KNLGTGEFTTTKAGTPYYVAPQVLDGK 231 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKKL 262 YD K D+WS GVI++ L+ GY PF + KK+ K EF W S+ AK L Sbjct: 232 -YD-KKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKA 292 I ++L NP R T E + + W + K+ Sbjct: 290 ITKLLTYNPNERCTIEEALNHPWITQMTKS 319 >5KCV-A nrPDB Length = 460 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 139/252 (55%), Gaps = 4/252 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 158 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 217 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 218 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 145 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 335 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 336 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 394 Query: 264 KRILDPNPATRI 275 +L +P R+ Sbjct: 395 SGLLKKDPKQRL 406 >3MV5-A nrPDB Length = 342 Score = 161 bits (408), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 139/252 (55%), Gaps = 4/252 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 145 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 183 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 184 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 242 Query: 264 KRILDPNPATRI 275 +L +P R+ Sbjct: 243 SGLLKKDPKQRL 254 >4C0T-A nrPDB Length = 974 Score = 161 bits (408), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 91/275 (33%), Positives = 147/275 (53%), Gaps = 17/275 (6%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM- 83 R V ++ G+ LGEG+++ V A + G A+KV+DK ++K K + + E + Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 +L VI ++ K +YFVL++ + GEL I L E+ R + Q+++A+ Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL-----------PQQVREDGLLHTTC 192 Y H GV HRDLKPEN+LLD ++++DFG + L P VR + Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFV---- 437 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP 252 GT YV+PE++ NK Y G D+W+ G I++ ++AG PF+ +N ++KI K +F Sbjct: 438 GTAEYVSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFS 496 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 F + LIK+IL P+ R T E+ ++ +F+ Sbjct: 497 AGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQ 531 >3GUB-A nrPDB Length = 295 Score = 160 bits (405), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 101/286 (35%), Positives = 153/286 (53%), Gaps = 24/286 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y+ G LG G FA VK R G A K I K + ++ I+RE+S +K I+ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPNVI + EV +KT + + E V GGELFD ++ L E+EA ++ +Q++N V Y HS Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 148 RGVYHRDLKPEN-LLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + H DLKPEN +LLD N +K+ DFGL+ ++ GTP +VAPE++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA---HKIDFGNEFKNIFGTPEFVAPEIV 189 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASA 259 N + G +AD+WS GVI ++L++G PF + L ++ ++ E SA A Sbjct: 190 NYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK---------KGYKAPKFE 296 K I+R+L +P R+T + +++ W K + P+FE Sbjct: 249 KDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAWSHPQFE 294 >3DB8-A nrPDB Length = 317 Score = 158 bits (400), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 93/262 (35%), Positives = 140/262 (53%), Gaps = 5/262 (1%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y GR LG+G FAK +++ + A KV+ K +LK ++ EI+ K + +P Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNP 102 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 +V+ +Y VLE L + + E EAR + +Q I V Y H+ Sbjct: 103 HVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNR 162 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEVINNKGY 208 V HRDLK NL L+ + +K+ DFGL+ ++ DG CGTPNY+APEV+ KG+ Sbjct: 163 VIHRDLKLGNLFLNDDMDVKIGDFGLAT---KIEFDGERKKDLCGTPNYIAPEVLCKKGH 219 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 + D+WS G IL+ L+ G PFE S L Y +I K E++ P + A LI+R+L Sbjct: 220 -SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLH 278 Query: 269 PNPATRITFAEVIENEWFKKGY 290 +P R + AE++ +E+F GY Sbjct: 279 ADPTLRPSVAELLTDEFFTSGY 300 >3ORZ-A nrPDB Length = 316 Score = 158 bits (399), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 139/254 (54%), Gaps = 9/254 (3%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 ++ G+ LGEG+F+ V AR + AIK+++K ++K + + RE M + HP Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++++ K+YF L + GEL I G E R Y ++++A++Y H +G+ Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 151 YHRDLKPENLLLDANGALKVSDFG----LSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 HRDLKPEN+LL+ + ++++DFG LS +Q R + + GT YV+PE++ K Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV----GTAQYVSPELLTEK 214 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 +DLW+ G I++ L+AG PF N +++KI K E+ P F A+ L++++ Sbjct: 215 S-ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKL 273 Query: 267 LDPNPATRITFAEV 280 L + R+ E+ Sbjct: 274 LVLDATKRLGCEEM 287 >4NIF-A nrPDB Length = 333 Score = 157 bits (398), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 100/288 (34%), Positives = 158/288 (54%), Gaps = 28/288 (9%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y + T+G G++++ K R V N+ A+KVIDK K ++ I + ++ +H Sbjct: 10 YVVKETIGVGSYSECK--RCVHKATNMEYAVKVIDKSKRDPSEEIEIL------LRYGQH 61 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+I + +V +Y V E + GGEL DKI E EA + V+Y HS+ Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 121 Query: 149 GVYHRDLKPENLL-LDANG---ALKVSDFGLSALPQQVR-EDGLLHTTCGTPNYVAPEVI 203 GV HRDLKP N+L +D +G L++ DFG + +Q+R E+GLL T C T N+VAPEV+ Sbjct: 122 GVVHRDLKPSNILYVDESGNPECLRICDFGFA---KQLRAENGLLMTPCYTANFVAPEVL 178 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCP--PW--FS 256 +GYD D+WS G++L+ ++AGY PF + + +I +FT W S Sbjct: 179 KRQGYDEG-CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVS 237 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP--KFENADVSL 302 +AK L+ ++L +P R+T +V+++ W + K P + + D+ L Sbjct: 238 ETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQL 285 >5FET-A nrPDB Length = 847 Score = 157 bits (398), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 95/271 (35%), Positives = 140/271 (51%), Gaps = 16/271 (5%) Query: 26 TRVGKYELG--RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 T+V +EL R +G GTF VK + A+K + K ++ IK E Sbjct: 528 TKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREIT 587 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 HP +IR+ YF+ E VTGGEL+D I G L + +A+ Y +I A++ Sbjct: 588 AENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIE 647 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 Y H R + +RDLKPEN+LLD G +K+ DFG + Q G +T GTP+Y+APEVI Sbjct: 648 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ-----GRAYTLVGTPHYMAPEVI 702 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWFS-ASAK 260 KGY G D+W+ GV L+ + G LPF + + +++ I + T P + S + Sbjct: 703 LGKGY-GCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSI 761 Query: 261 KLIKRILDPNPATRI-----TFAEVIENEWF 286 L+KR+L P RI F ++ E+ +F Sbjct: 762 NLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >3HDN-A nrPDB Length = 373 Score = 157 bits (398), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 8/273 (2%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G SS + + + +G+G+F KV AR+ A+KV+ K+ +LK K I Sbjct: 28 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 87 Query: 79 EISTM-KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E + + K +KHP ++ + + K+YFVL+++ GGELF + E AR Y + Sbjct: 88 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 147 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + +A+ Y HS + +RDLKPEN+LLD+ G + ++DFGL + + + T CGTP Y Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK--ENIEHNSTTSTFCGTPEY 205 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 +APEV++ + YD D W G +L+ ++ G PF N +Y I P + Sbjct: 206 LAPEVLHKQPYDRT-VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITN 264 Query: 258 SAKKLIKRILDPNPATRI----TFAEVIENEWF 286 SA+ L++ +L + R+ F E+ + +F Sbjct: 265 SARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >2WTK-C nrPDB Length = 305 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 88/280 (31%), Positives = 145/280 (51%), Gaps = 33/280 (11%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI-------------- 73 +GKY +G LGEG++ KVK +V+D E + + + Sbjct: 4 IGKYLMGDLLGEGSYGKVK-------------EVLDSETLCRRAVKILKKKKLRRIPNGE 50 Query: 74 AQIKREISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVTGG--ELFDKISSNGRLKED 129 A +K+EI ++ ++H NVI++ +V+ + K K+Y V+E+ G E+ D + R Sbjct: 51 ANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVC 109 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 +A YF QLI+ ++Y HS+G+ H+D+KP NLLL G LK+S G++ D Sbjct: 110 QAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCR 169 Query: 190 TTCGTPNYVAPEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 T+ G+P + PE+ N + G K D+WS GV L+ + G PFE N+ L++ I K Sbjct: 170 TSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGS 229 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 + P L+K +L+ PA R + ++ ++ WF+K Sbjct: 230 YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRK 269 >5DYK-A nrPDB Length = 853 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 87/254 (34%), Positives = 132/254 (51%), Gaps = 9/254 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + + + E R +G GTF VK + A+K + K ++ IK E Sbjct: 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 HP +IR+ YF+ E VTGGEL+D I G L + +A+ Y +I A++Y Sbjct: 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 H R + +RDLKPEN+LLD G +K+ DFG + Q G +T GTP+Y+APEVI Sbjct: 655 LHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ-----GRAYTLVGTPHYMAPEVIL 709 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWFS-ASAKK 261 KGY G D+W+ G+ L+ + G LPF ++ + +++ I + T P + + + Sbjct: 710 GKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSIN 768 Query: 262 LIKRILDPNPATRI 275 L+KR+L P RI Sbjct: 769 LMKRLLCRLPQGRI 782 >2Y7J-A nrPDB Length = 365 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 86/275 (31%), Positives = 149/275 (54%), Gaps = 20/275 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVID-KEKVLKNKMIAQIK----REISTMK 84 KY+ +G G + V+ + G A+K+++ + L + + +++ RE ++ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 85 LIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 + HP++I + + S + ++ V + + GELFD ++ L E E R + L+ AV Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + H+ + HRDLKPEN+LLD N +++SDFG S + L CGTP Y+APE++ Sbjct: 215 FLHANNIVHRDLKPENILLDDNMQIRLSDFGFSC---HLEPGEKLRELCGTPGYLAPEIL 271 Query: 204 ------NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW- 254 + GY G + DLW+CGVILF L+AG PF + + I + +F+ P W Sbjct: 272 KCSMDETHPGY-GKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWD 330 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 S++ K LI R+L +P R+T + +++ +F++ Sbjct: 331 DRSSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >2YAB-A nrPDB Length = 361 Score = 155 bits (392), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 95/270 (35%), Positives = 151/270 (55%), Gaps = 23/270 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK---MIAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN+I + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPEN-LLLDAN---GALKVSDFGLSALPQQVREDGL-LHTTCGTPNYVAPEV 202 + + H DLKPEN +LLD N +K+ DFGL+ EDG+ GTP +VAPE+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA----HEIEDGVEFKNIFGTPEFVAPEI 189 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPF-------EDSNLTSLYKKIFKAEFTCPPWF 255 +N + G +AD+WS GVI ++L++G PF +N+T++ F EF Sbjct: 190 VNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD-FDEEFFSQT-- 245 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEW 285 S AK I+++L R+T E + + W Sbjct: 246 SELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4JG6-A nrPDB Length = 355 Score = 155 bits (392), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 96/280 (34%), Positives = 153/280 (54%), Gaps = 26/280 (9%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 YE+ +G G+++ K R + N+ A+K+IDK K + I + ++ +H Sbjct: 37 YEVKEDIGVGSYSVCK--RCIHKATNMEFAVKIIDKSKRDPTEEIEIL------LRYGQH 88 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+I + +V +Y V E + GGEL DKI E EA + V+Y H++ Sbjct: 89 PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ 148 Query: 149 GVYHRDLKPENLL-LDANG---ALKVSDFGLSALPQQVR-EDGLLHTTCGTPNYVAPEVI 203 GV HRDLKP N+L +D +G ++++ DFG + +Q+R E+GLL T C T N+VAPEV+ Sbjct: 149 GVVHRDLKPSNILYVDESGNPESIRICDFGFA---KQLRAENGLLMTPCYTANFVAPEVL 205 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFE---DSNLTSLYKKIFKAEFTCPP--WFSAS 258 +GYD A D+WS GV+L+ ++ GY PF D + +I +F+ W S S Sbjct: 206 ERQGYDAA-CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVS 264 Query: 259 --AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFE 296 AK L+ ++L +P R+T A V+ + W + P+++ Sbjct: 265 DTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQ 304 >1ZWS-A nrPDB Length = 288 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/270 (35%), Positives = 150/270 (55%), Gaps = 23/270 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NVI + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPEN-LLLDAN---GALKVSDFGLSALPQQVREDGL-LHTTCGTPNYVAPEV 202 + + H DLKPEN +LLD N +K+ DFGL+ EDG+ GTP +VAPE+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA----HEIEDGVEFKNIFGTPEFVAPEI 189 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFED-------SNLTSLYKKIFKAEFTCPPWF 255 +N + G +AD+WS GVI ++L++G PF +N+TS+ F EF Sbjct: 190 VNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYD-FDEEFFSHT-- 245 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEW 285 S AK I+++L R+T E + + W Sbjct: 246 SELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >2A27-A nrPDB Length = 321 Score = 152 bits (383), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 95/270 (35%), Positives = 150/270 (55%), Gaps = 23/270 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NVI + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPEN-LLLDAN---GALKVSDFGLSALPQQVREDGL-LHTTCGTPNYVAPEV 202 + + H DLKPEN +LLD N +K+ DFGL+ EDG+ GTP +VAPE+ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA----HEIEDGVEFKNIFGTPEFVAPEI 189 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFED-------SNLTSLYKKIFKAEFTCPPWF 255 +N + G +AD+WS GVI ++L++G PF +N+T++ F EF Sbjct: 190 VNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD-FDEEFFSQT-- 245 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEW 285 S AK I+++L R+T E + + W Sbjct: 246 SELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >3IS5-A nrPDB Length = 285 Score = 151 bits (381), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 92/266 (34%), Positives = 141/266 (53%), Gaps = 19/266 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG G F V +G IK I+K++ + QI+ EI +K + HPN+I++ Sbjct: 28 RKLGSGAFGDVHLVEERSSGLERVIKTINKDR--SQVPMEQIEAEIEVLKSLDHPNIIKI 85 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKI-SSNGR---LKEDEARKYFQQLINAVDYCHSRGV 150 FEV +Y V+E GGEL ++I S+ R L E + +Q++NA+ Y HS+ V Sbjct: 86 FEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHV 145 Query: 151 YHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 H+DLKPEN+L + +K+ DFGL+ L + D GT Y+APEV Sbjct: 146 VHKDLKPENILFQDTSPHSPIKIIDFGLAEL---FKSDEHSTNAAGTALYMAPEVFKRDV 202 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE----FTCPPWFSASAKKLI 263 K D+WS GV+++ L+ G LPF ++L + +K E C P + A L+ Sbjct: 203 --TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRP-LTPQAVDLL 259 Query: 264 KRILDPNPATRITFAEVIENEWFKKG 289 K++L +P R + A+V+ +EWFK+ Sbjct: 260 KQMLTKDPERRPSAAQVLHHEWFKQA 285 >4WNO-A nrPDB Length = 287 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 96/280 (34%), Positives = 155/280 (55%), Gaps = 23/280 (8%) Query: 23 GGRTRVGKYELGR--TLGEGTFAKVKFARNVENGD-NVAIKVIDKEKVLKNKMIAQIKRE 79 GG VGK+E R +G G FA V R+ D VA+K I+K+ + K++ + + +E Sbjct: 10 GGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKE 67 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 I +K +KH N++ +++ +Y V+E+ GG+L D + + L ED R + QQ+ Sbjct: 68 IKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIA 127 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGA----------LKVSDFGLSALPQQVREDGLLH 189 A+ HS+G+ HRDLKP+N+LL +N A +K++DFG + + ++ + + Sbjct: 128 GAMRLLHSKGIIHRDLKPQNILL-SNPAGRRANPNSIRVKIADFGFA---RYLQSNMMAA 183 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS---NLTSLYKKIFK 246 T CG+P Y+APEVI ++ YDG KADLWS G I++ + G PF+ S +L Y+K Sbjct: 184 TLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 242 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 T P SA ++L+ +L N R+ F E + + Sbjct: 243 LVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >6FDY-U nrPDB Length = 276 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 90/268 (33%), Positives = 143/268 (53%), Gaps = 11/268 (4%) Query: 24 GRTRVGKYELGRTLGEGTFAKV-KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G R+ + L LG GT+A V K + + VAIK + K K L + + EI Sbjct: 6 GPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAK-KSLNKASVENLLTEIEI 64 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +K I+HP+++++ + IY ++EF GG+L I + L E AR + QQL +A+ Sbjct: 65 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASAL 124 Query: 143 DYCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 + H R + H DLKP+N+LL + LK++DFG + Q + H G+P Y+AP Sbjct: 125 QFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFA---QHMSPWDEKHVLRGSPLYMAP 181 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK---AEFTCPPWFSA 257 E++ + YD A+ DLWS GVIL+ + G PF + + L +KI E P S Sbjct: 182 EMVCQRQYD-ARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSR 240 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEW 285 + L++R+L+ +P+ RI+F + + W Sbjct: 241 DCRDLLQRLLERDPSRRISFQDFFAHPW 268 >2OU7-A nrPDB Length = 335 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 93/279 (33%), Positives = 140/279 (50%), Gaps = 16/279 (5%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG+G FAK + + + A K++ K +LK ++ EIS + + H +V+ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 ++ VLE L + L E EAR Y +Q++ Y H V HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEVINNKGYDGAKADL 215 NL L+ + +K+ DFGL+ +V DG CGTPNY+APEV++ KG+ + D+ Sbjct: 169 LGNLFLNEDLEVKIGDFGLAT---KVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDV 224 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 WS G I++ L+ G PFE S L Y +I K E++ P + A LI+++L +P R Sbjct: 225 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARP 284 Query: 276 TFAEVIENEWFKKGY-----------KAPKFENADVSLD 303 T E++ +E+F GY P+F A SLD Sbjct: 285 TINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLD 323 >2EHB-D nrPDB Length = 143 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 65/127 (51%), Positives = 94/127 (74%) Query: 330 PVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDVK 389 P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A MGF Sbjct: 4 PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFKSH 63 Query: 390 TNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLTTGLKD 449 T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L + L++ Sbjct: 64 TRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSKLEN 123 Query: 450 IVWKTID 456 I+W+ + Sbjct: 124 IIWRATE 130 >3A8W-A nrPDB Length = 345 Score = 148 bits (373), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 84/273 (30%), Positives = 151/273 (55%), Gaps = 19/273 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 ++L R +G G++AKV R + A+KV+ KE V ++ I ++ E + HP Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++ + ++++++FV+E+V GG+L + +L E+ AR Y ++ A++Y H RG Sbjct: 71 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG 130 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 + +RDLK +N+LLD+ G +K++D+G+ + +R T CGTPNY+APE++ + Y Sbjct: 131 IIYRDLKLDNVLLDSEGHIKLTDYGMCK--EGLRPGDTTSTFCGTPNYIAPEILRGEDY- 187 Query: 210 GAKADLWSCGVILFVLMAGYLPFE--------DSNLTS-LYKKIFKAEFTCPPWFSASAK 260 G D W+ GV++F +MAG PF+ D N L++ I + + P S A Sbjct: 188 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 247 Query: 261 KLIKRILDPNPATRI------TFAEVIENEWFK 287 ++K L+ +P R+ FA++ + +F+ Sbjct: 248 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 >4J52-A nrPDB Length = 293 Score = 148 bits (373), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 87/255 (34%), Positives = 133/255 (52%), Gaps = 5/255 (1%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG+G FAK + + + A K++ K +LK ++ EIS + + H +V+ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 ++ VLE L + L E EAR Y +Q++ Y H V HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAPEVINNKGYDGAKADL 215 NL L+ + +K+ DFGL+ +V DG CGTPNY+APEV++ KG+ + D+ Sbjct: 142 LGNLFLNEDLEVKIGDFGLAT---KVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDV 197 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 WS G I++ L+ G PFE S L Y +I K E++ P + A LI+++L +P R Sbjct: 198 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARP 257 Query: 276 TFAEVIENEWFKKGY 290 T E++ +E+F GY Sbjct: 258 TINELLNDEFFTSGY 272 >4RA4-A nrPDB Length = 355 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 81/267 (30%), Positives = 147/267 (55%), Gaps = 6/267 (2%) Query: 11 TPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 +PS S++ R ++ + LG+G+F KV A + AIK++ K+ V+++ Sbjct: 2 SPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQD 61 Query: 71 KMIAQIKREISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED 129 + E + L+ K P + ++ + ++YFV+E+V GG+L I G+ KE Sbjct: 62 DDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP 121 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL-L 188 +A Y ++ + + H RG+ +RDLK +N++LD+ G +K++DFG+ ++ DG+ Sbjct: 122 QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC---KEHMMDGVTT 178 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 T CGTP+Y+APE+I + Y G D W+ GV+L+ ++AG PF+ + L++ I + Sbjct: 179 RTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHN 237 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRI 275 + P S A + K ++ +PA R+ Sbjct: 238 VSYPKSLSKEAVSICKGLMTKHPAKRL 264 >1VZO-A nrPDB Length = 355 Score = 144 bits (362), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 90/289 (31%), Positives = 158/289 (54%), Gaps = 20/289 (6%) Query: 18 SGSSSGGRTRVG--KYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVL-KNK 71 + + +G +VG +EL + LG G + KV R + D A+KV+ K ++ K K Sbjct: 41 TANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAK 100 Query: 72 MIAQIKREISTMKLIKH-PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE 130 + E ++ I+ P ++ + ++TK++ +L+++ GGELF +S R E E Sbjct: 101 TTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHE 160 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT 190 + Y +++ A+++ H G+ +RD+K EN+LLD+NG + ++DFGLS E + Sbjct: 161 VQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSK-EFVADETERAYD 219 Query: 191 TCGTPNYVAPEVIN--NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKI 244 CGT Y+AP+++ + G+D A D WS GV+++ L+ G PF E ++ + ++I Sbjct: 220 FCGTIEYMAPDIVRGGDSGHDKA-VDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI 278 Query: 245 FKAEFTCPPWFSASAKKLIKRILDPNPATRITFA-----EVIENEWFKK 288 K+E P SA AK LI+R+L +P R+ E+ E+ +F+K Sbjct: 279 LKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >4X7Q-B nrPDB Length = 312 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 135/267 (50%), Gaps = 19/267 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIK- 87 +Y LG LG+G F V + + VAIKVI + +VL ++ + + L K Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 88 -----HPNVIRMFEVMASKTKIYFVLE-FVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 HP VIR+ + ++ VLE + +LFD I+ G L E +R +F Q++ A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 142 VDYCHSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 + +CHSRGV HRD+K EN+L+D G K+ DFG AL D GT Y P Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGAL----LHDEPYTDFDGTRVYSPP 207 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E I+ Y A +WS G++L+ ++ G +PFE ++I +AE P S Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCC 261 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+R L P P++R + E++ + W + Sbjct: 262 ALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >5F9E-A nrPDB Length = 353 Score = 142 bits (357), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 134/252 (53%), Gaps = 4/252 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + ++ +EL + LG+G+F KV A + AIK + K+ VL + + E + Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 L +HP + MF +K ++FV+E++ GG+L I S + A Y ++I + Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + HS+G+ +RDLK +N+LLD +G +K++DFG+ + + D + CGTP+Y+APE++ Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK--ENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y+ + D WS GV+L+ ++ G PF + L+ I P W AK L+ Sbjct: 193 LGQKYNHS-VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLL 251 Query: 264 KRILDPNPATRI 275 ++ P R+ Sbjct: 252 VKLFVREPEKRL 263 >5LOH-A nrPDB Length = 341 Score = 142 bits (357), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 71/229 (31%), Positives = 124/229 (54%), Gaps = 7/229 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + ++ + + + G F KV + + G A+KV+ K ++ M Q++ E + L K Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 P ++ ++ + S +Y V+E++ GG++ + G E+ A KY ++ A+DY H Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLS--ALPQQVREDGLL--HTTCGTPNYVAPEVI 203 G+ HRDLKP+N+L+ G +K++DFGLS L + + +L T CGTP+Y+APE++ Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP 252 + + G D W+ GV LF + G PF D +++ I K + P Sbjct: 213 LGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWP 260 >1PHK-A nrPDB Length = 298 Score = 141 bits (355), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 145/293 (49%), Gaps = 27/293 (9%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID--------KEK 66 + P S+ G YE LG G + V+ + A+K+ID E+ Sbjct: 5 ALPGSHSTHGFYE--NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEE 62 Query: 67 VLKNKMIAQIKREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR 125 V ++ +E+ ++ + HPN+I++ + + T + V + + GELFD ++ Sbjct: 63 V--QELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVT 120 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 L E E RK + L+ + H + HRDLKPEN+LLD + +K++DFG S Q+ Sbjct: 121 LSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSC---QLDPG 177 Query: 186 GLLHTTCGTPNYVAPEVI------NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 L CGTP+Y+APE+I N+ GY G + D+WS GVI++ L+AG PF Sbjct: 178 EKLREVCGTPSYLAPEIIECSMNDNHPGY-GKEVDMWSTGVIMYTLLAGSPPFWHRKQML 236 Query: 240 LYKKIFKA--EFTCPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 + + I +F P W +S + K L+ R L P R T E + + +F++ Sbjct: 237 MLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >6BDL-A nrPDB Length = 347 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 139/271 (51%), Gaps = 16/271 (5%) Query: 27 RVGKYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 ++ + + TLG G F +V+ + E A+K++ K ++ + I+ E M+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 ++R++ +Y ++E GGEL+ + G ++ R Y ++ A Y Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS+G+ +RDLKPENL+LD G K+ DFG + +++ T CGTP YVAPE+I N Sbjct: 152 HSKGIIYRDLKPENLILDHRGYAKLVDFGFA---KKIGFGKKTWTFCGTPEYVAPEIILN 208 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA----EFTCPPWFSASAKK 261 KG+D AD WS G++++ L+ G PF + Y I + EF P + +A Sbjct: 209 KGHD-ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEF--PKKIAKNAAN 265 Query: 262 LIKRILDPNPATRI-----TFAEVIENEWFK 287 LIK++ NP+ R+ ++ +++WF+ Sbjct: 266 LIKKLCRDNPSERLGNLKNGVKDIQKHKWFE 296 >6QAU-A nrPDB Length = 280 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 80/236 (33%), Positives = 135/236 (57%), Gaps = 21/236 (8%) Query: 23 GGRTRVGKYELGR--TLGEGTFAKVKFARNVENGD-NVAIKVIDKEKVLKNKMIAQIKRE 79 G VG +E + +G G FA V R+ + D VAIK I+K+ + K++++ + +E Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKE 60 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 I +K ++H N++ +++V ++ V+E+ GG+L D + + G L ED R + Q+ Sbjct: 61 IKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIA 120 Query: 140 NAVDYCHSRGVYHRDLKPENLLLD-ANG--------ALKVSDFGLSALPQQVREDGLLHT 190 A+ HS+G+ HRDLKP+N+LL AN +K++DFG + + + + + Sbjct: 121 AAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFA---RYLHSNMMAAD 177 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE---DSNLTSLYKK 243 CG+P Y+APEVI ++ YD AKADLWS G +++ + G PF+ +L Y+K Sbjct: 178 LCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEK 232 >6ED6-A nrPDB Length = 415 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 83/254 (32%), Positives = 139/254 (54%), Gaps = 13/254 (5%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G + + Y++ + +G G F +V+ R+ + A+K++ K +++K A E Sbjct: 82 GLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI 141 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 M P V+++F +Y V+E++ GG+L + + SN + E A+ Y +++ A+ Sbjct: 142 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLAL 200 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH--TTCGTPNYVAP 200 D HS G+ HRD+KP+N+LLD +G LK++DFG ++ E G++H T GTP+Y++P Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC---MKMDETGMVHCDTAVGTPDYISP 257 Query: 201 EVINNKGYD---GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT-CPP--- 253 EV+ ++G D G + D WS GV L+ ++ G PF +L Y KI + + C P Sbjct: 258 EVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDA 317 Query: 254 WFSASAKKLIKRIL 267 S AK LI L Sbjct: 318 EISKHAKNLICAFL 331 >4APC-A nrPDB Length = 350 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 81/272 (29%), Positives = 147/272 (54%), Gaps = 16/272 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KY + +GEG+F K ++ E+G IK I+ + + +K + +RE++ + +KHP Sbjct: 25 KYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISR-MSSKEREESRREVAVLANMKHP 83 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRL-KEDEARKYFQQLINAVDYCHS 147 N+++ E +Y V+++ GG+LF +I++ G L +ED+ +F Q+ A+ + H Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHD 143 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 R + HRD+K +N+ L +G +++ DFG++ + E L GTP Y++PE+ NK Sbjct: 144 RKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVE--LARACIGTPYYLSPEICENKP 201 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP---WFSASAKKLIK 264 Y+ K+D+W+ G +L+ L FE ++ +L KI F PP +S + L+ Sbjct: 202 YNN-KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSF--PPVSLHYSYDLRSLVS 258 Query: 265 RILDPNPATRITFAEVIENEWFKKGYKAPKFE 296 ++ NP R + ++E KG+ A + E Sbjct: 259 QLFKRNPRDRPSVNSILE-----KGFIAKRIE 285 >3PFQ-A nrPDB Length = 674 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 135/252 (53%), Gaps = 4/252 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R ++ + LG+G+F KV + + A+K++ K+ V+++ + E + Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 L K P + ++ + ++YFV+E+V GG+L I GR KE A Y ++ + Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + S+G+ +RDLK +N++LD+ G +K++DFG+ + + + T CGTP+Y+APE+I Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEII 514 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W+ GV+L+ ++AG PFE + L++ I + P S A + Sbjct: 515 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 573 Query: 264 KRILDPNPATRI 275 K ++ +P R+ Sbjct: 574 KGLMTKHPGKRL 585 >2I0E-A nrPDB Length = 353 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 135/252 (53%), Gaps = 4/252 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R ++ + LG+G+F KV + + A+K++ K+ V+++ + E + Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 L K P + ++ + ++YFV+E+V GG+L I GR KE A Y ++ + Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + S+G+ +RDLK +N++LD+ G +K++DFG+ + + + T CGTP+Y+APE+I Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEII 193 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W+ GV+L+ ++AG PFE + L++ I + P S A + Sbjct: 194 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 264 KRILDPNPATRI 275 K ++ +P R+ Sbjct: 253 KGLMTKHPGKRL 264 >6BXI-A nrPDB Length = 333 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 86/280 (30%), Positives = 133/280 (47%), Gaps = 40/280 (14%) Query: 26 TRVG--KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 TR+G +E + +G G F +V+ + + G A+K++ K +L+ + + I+ E + Sbjct: 1 TRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL 60 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 V++MF K +Y ++EF+ GG++ + L E+E + Y + + A+D Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLS-----------------ALPQQV---- 182 H G HRD+KP+NLLLD+ G +K+SDFGL +LP Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 183 ------------REDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL 230 L +T GTP+Y+APEV GY+ D WS GVI++ ++ GY Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKL-CDWWSLGVIMYEMLIGYP 239 Query: 231 PFEDSNLTSLYKKI--FKAEFTCPPW--FSASAKKLIKRI 266 PF YKK+ +K T PP S AK LI R Sbjct: 240 PFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 279 >6E9W-A nrPDB Length = 443 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 135/252 (53%), Gaps = 13/252 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + YE+ + +G G F +V+ R+ A+K++ K +++K A E M Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 P V+++F +Y V+E++ GG+L + + SN + E AR Y +++ A+D Sbjct: 158 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDA 216 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH--TTCGTPNYVAPEV 202 HS G HRD+KP+N+LLD +G LK++DFG ++ ++G++ T GTP+Y++PEV Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC---MKMNKEGMVRCDTAVGTPDYISPEV 273 Query: 203 INNK---GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPP--WF 255 + ++ GY G + D WS GV L+ ++ G PF +L Y KI K T P Sbjct: 274 LKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDI 333 Query: 256 SASAKKLIKRIL 267 S AK LI L Sbjct: 334 SKEAKNLICAFL 345 >6CCF-A nrPDB Length = 290 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 73/222 (32%), Positives = 126/222 (56%), Gaps = 9/222 (4%) Query: 73 IAQIKREISTMKLIKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSNGRLKEDE 130 + ++ +EI+ +K + H NV+++ EV+ ++ +Y V + + G + + + + E++ Sbjct: 72 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQ 130 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT 190 AR Y + +I ++Y H + + HRD+KP NLLL +G +K++DFG+S Q D L + Sbjct: 131 ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSN--QFEGNDAQLSS 188 Query: 191 TCGTPNYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 T GTP ++APE I++ G + G D+W+ GV L+ + G PF D + +L++KI Sbjct: 189 TAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEP 248 Query: 249 FTCP--PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 P P S K LI ++LD NP TRI ++ + W K Sbjct: 249 VVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >4FR4-A nrPDB Length = 384 Score = 135 bits (339), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 75/276 (27%), Positives = 148/276 (53%), Gaps = 12/276 (4%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 S P +E+ R +G+G+F KV + + A+K ++K+K ++ + Sbjct: 1 SMPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVR 60 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 + +E+ M+ ++HP ++ ++ + ++ V++ + GG+L + N KE+ + + Sbjct: 61 NVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLF 120 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCG 193 +L+ A+DY ++ + HRD+KP+N+LLD +G + ++DF ++A LP++ + + T G Sbjct: 121 ICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQ----ITTMAG 176 Query: 194 TPNYVAPEVINNK---GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE-- 248 T Y+APE+ +++ GY A D WS GV + L+ G P+ + TS + + E Sbjct: 177 TKPYMAPEMFSSRKGAGYSFA-VDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETT 235 Query: 249 -FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 T P +S L+K++L+PNP R + ++N Sbjct: 236 VVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQN 271 >3UTO-A nrPDB Length = 573 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 82/274 (29%), Positives = 139/274 (50%), Gaps = 30/274 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVI------DKEKVLKNKMIAQIKREISTMK 84 Y++ LG G F V G+N A K + DKE V ++EI TM Sbjct: 159 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETV---------RKEIQTMS 209 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVD 143 +++HP ++ + + ++ + EF++GGELF+K++ + ++ EDEA +Y +Q+ + Sbjct: 210 VLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLC 269 Query: 144 YCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSAL--PQQVREDGLLHTTCGTPNYVA 199 + H H DLKPEN++ + LK+ DFGL+A P+Q + T GT + A Sbjct: 270 HMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS-----VKVTTGTAEFAA 324 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWF 255 PEV K G D+WS GV+ ++L++G PF +D L ++ + + + Sbjct: 325 PEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGI 383 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 S K I+++L +P TR+T + +E+ W G Sbjct: 384 SEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPG 417 >1KOA-A nrPDB Length = 491 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 82/277 (29%), Positives = 140/277 (50%), Gaps = 30/277 (10%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI------DKEKVLKNKMIAQIKREIS 81 + Y++ LG G F V G+N A K + DKE V ++EI Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETV---------RKEIQ 100 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLIN 140 TM +++HP ++ + + ++ + EF++GGELF+K++ + ++ EDEA +Y +Q+ Sbjct: 101 TMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCK 160 Query: 141 AVDYCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSAL--PQQVREDGLLHTTCGTPN 196 + + H H DLKPEN++ + LK+ DFGL+A P+Q + T GT Sbjct: 161 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS-----VKVTTGTAE 215 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCP 252 + APEV K G D+WS GV+ ++L++G PF +D L ++ + + + Sbjct: 216 FAAPEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF 274 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 S K I+++L +P TR+T + +E+ W G Sbjct: 275 SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPG 311 >2HW6-A nrPDB Length = 307 Score = 134 bits (337), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 85/286 (29%), Positives = 144/286 (50%), Gaps = 41/286 (14%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIRMF 95 LGEG +AKV+ A +++NG A+K+I+K+ +++ RE+ T+ + + N++ + Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEKQA---GHSRSRVFREVETLYQCQGNKNILELI 77 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 E T+ Y V E + GG + I E EA + + + A+D+ H++G+ HRDL Sbjct: 78 EFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDL 137 Query: 156 KPENLLLDAN---GALKVSDFGL--------SALPQQVREDGLLHTTCGTPNYVAPEVI- 203 KPEN+L ++ +K+ DF L S P E L T CG+ Y+APEV+ Sbjct: 138 KPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE---LTTPCGSAEYMAPEVVE 194 Query: 204 ---NNKGYDGAKADLWSCGVILFVLMAGYLPF-----------EDSNLTSLYKKIF---- 245 + + + DLWS GV+L+++++GY PF K+F Sbjct: 195 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 254 Query: 246 --KAEFTCPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 K EF W S+ AK LI ++L + R++ A+V+++ W + Sbjct: 255 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >2WQN-A nrPDB Length = 310 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 83/261 (31%), Positives = 136/261 (52%), Gaps = 15/261 (5%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + + + + +G G F++V A + +G VA+K + ++ K A +EI + Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK----EDEARKYFQQLI 139 K + HPNVI+ + ++ VLE G+L I + K E KYF QL Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +A+++ HSR V HRD+KP N+ + A G +K+ D GL + H+ GTP Y++ Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS--KTTAAHSLVGTPYYMS 204 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPW--- 254 PE I+ GY+ K+D+WS G +L+ + A PF + NL SL KKI + ++ PP Sbjct: 205 PERIHENGYN-FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDY--PPLPSD 261 Query: 255 -FSASAKKLIKRILDPNPATR 274 +S ++L+ ++P+P R Sbjct: 262 HYSEELRQLVNMCINPDPEKR 282 >1NY3-A nrPDB Length = 400 Score = 132 bits (331), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 30/279 (10%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST-MKLIKHPNVI 92 + LG G KV N + A+K++ + +RE+ + + P+++ Sbjct: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIV 118 Query: 93 RMFEVM----ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCH 146 R+ +V A + + V+E + GGELF +I G E EA + + + A+ Y H Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 147 SRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S + HRD+KPENLL + N LK++DFG + ++ L T C TP YVAPEV+ Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAPEVL 235 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPPW--F 255 + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF P W Sbjct: 236 GPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 294 S K LI+ +L P R+T E + + W + K P+ Sbjct: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 >2OZA-A nrPDB Length = 356 Score = 131 bits (330), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 30/279 (10%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST-MKLIKHPNVI 92 + LG G KV N + A+K++ + +RE+ + + P+++ Sbjct: 23 SQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIV 74 Query: 93 RMFEVM----ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCH 146 R+ +V A + + V+E + GGELF +I G E EA + + + A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 147 SRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S + HRD+KPENLL + N LK++DFG + ++ L T C TP YVAPEV+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAPEVL 191 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPPW--F 255 + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF P W Sbjct: 192 GPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 250 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 294 S K LI+ +L P R+T E + + W + K P+ Sbjct: 251 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 289 >3KA0-A nrPDB Length = 320 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 84/279 (30%), Positives = 138/279 (49%), Gaps = 30/279 (10%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST-MKLIKHPNVI 92 + LG G KV N + A+K++ + +RE+ + + P+++ Sbjct: 21 SQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIV 72 Query: 93 RMFEVM----ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCH 146 R+ +V A + + V+E + GGELF +I G E EA + + + A+ Y H Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 147 SRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S + HRD+KPENLL + N LK++DFG + ++ L C TP YVAPEV+ Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTEPCYTPYYVAPEVL 189 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPPW--F 255 + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF P W Sbjct: 190 GPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 248 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 294 S K LI+ +L P R+T E + + W + K P+ Sbjct: 249 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 287 >3HKO-A nrPDB Length = 345 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 93/311 (29%), Positives = 149/311 (47%), Gaps = 53/311 (17%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV--LKNKMIAQIKREISTMKLIK 87 KY L +G+G++ V+ A + AIK+++K K+ + K + +IK E+ MK + Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-----SNGRLKED------------- 129 HPN+ R++EV + I V+E GG L DK++ S G+ D Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 130 ------------EARKYFQ----------QLINAVDYCHSRGVYHRDLKPENLLLDANGA 167 E+ + Q Q+ +A+ Y H++G+ HRD+KPEN L N + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 168 --LKVSDFGLSALPQQVR--EDGLLHTTCGTPNYVAPEVIN--NKGYDGAKADLWSCGVI 221 +K+ DFGLS ++ E + T GTP +VAPEV+N N+ Y G K D WS GV+ Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY-GPKCDAWSAGVL 265 Query: 222 LFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPPW--FSASAKKLIKRILDPNPATRITF 277 L +L+ G +PF N ++ K F P + S A+ L+ +L+ N R Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDA 325 Query: 278 AEVIENEWFKK 288 +++ W + Sbjct: 326 MRALQHPWISQ 336 >3DLS-A nrPDB Length = 335 Score = 129 bits (323), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 82/263 (31%), Positives = 137/263 (52%), Gaps = 17/263 (6%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI-----AQIKREISTMK 84 KY LG G F V A + E V +K I KEKVL++ I ++ EI+ + Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLE-FVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 ++H N+I++ ++ ++ V+E +G +LF I + RL E A F+QL++AV Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 Y + + HRD+K EN+++ + +K+ DFG +A ++ + L +T CGT Y APEV+ Sbjct: 145 YLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK---LFYTFCGTIEYCAPEVL 201 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF-SASAKKL 262 Y G + ++WS GV L+ L+ FE++ L + + A PP+ S L Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLV-----FEENPFCELEETVEAA--IHPPYLVSKELMSL 254 Query: 263 IKRILDPNPATRITFAEVIENEW 285 + +L P P R T +++ + W Sbjct: 255 VSGLLQPVPERRTTLEKLVTDPW 277 >5CEK-A nrPDB Length = 263 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 132/268 (49%), Gaps = 13/268 (4%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S+ G +R+ Y L L V A + G + KV K ++K+ I+ Sbjct: 4 SAPGPSRIADYLL---LPLAEREHVSRALCIHTGRELRCKVFPI-KHYQDKIRPYIQ--- 56 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 L H N+ + EV+ +TK Y E G++ + S RL+E+EA + F+Q+++ Sbjct: 57 ----LPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 111 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 AV +CH + DLK + ++ L ED L G P YV+P Sbjct: 112 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 171 Query: 201 EVINNKG-YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 E++N G Y G AD+WS GV+L+ L+ G PF DS+ ++L+ KI + +F P S A Sbjct: 172 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 231 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK 287 + LI+ +L P+ R+T E++ + WF+ Sbjct: 232 RCLIRSLLRREPSERLTAPEILLHPWFE 259 >2X4F-A nrPDB Length = 373 Score = 127 bits (320), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 137/267 (51%), Gaps = 20/267 (7%) Query: 31 YELGRT--LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y + +T LG G F +V G +A K+I K + +K+K ++K EIS M + H Sbjct: 89 YTVSKTEILGGGRFGQVHKCEETATGLKLAAKII-KTRGMKDK--EEVKNEISVMNQLDH 145 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDK-ISSNGRLKEDEARKYFQQLINAVDYCHS 147 N+I++++ SK I V+E+V GGELFD+ I + L E + + +Q+ + + H Sbjct: 146 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQ 205 Query: 148 RGVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + H DLKPEN+L A +K+ DFGL+ ++ + L GTP ++APEV+N Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGLA---RRYKPREKLKVNFGTPEFLAPEVVN- 261 Query: 206 KGYDGAK--ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASA 259 YD D+WS GVI ++L++G PF N I + S A Sbjct: 262 --YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEA 319 Query: 260 KKLIKRILDPNPATRITFAEVIENEWF 286 K+ I ++L + RI+ +E +++ W Sbjct: 320 KEFISKLLIKEKSWRISASEALKHPWL 346 >6DC0-A nrPDB Length = 292 Score = 127 bits (320), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 132/268 (49%), Gaps = 13/268 (4%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S+ G +R+ Y L L V A + G + KV K ++K+ I+ Sbjct: 1 SAPGPSRIADYLL---LPLAEREHVSRALCIHTGRELRCKVFPI-KHYQDKIRPYIQ--- 53 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 L H N+ + EV+ +TK Y E G++ + S RL+E+EA + F+Q+++ Sbjct: 54 ----LPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 108 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 AV +CH + DLK + ++ L ED L G P YV+P Sbjct: 109 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 168 Query: 201 EVINNKG-YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 E++N G Y G AD+WS GV+L+ L+ G PF DS+ ++L+ KI + +F P S A Sbjct: 169 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 228 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK 287 + LI+ +L P+ R+T E++ + WF+ Sbjct: 229 RCLIRSLLRREPSERLTAPEILLHPWFE 256 >1KOB-A nrPDB Length = 387 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 81/264 (30%), Positives = 132/264 (50%), Gaps = 14/264 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y++ LG G F V G K I+ L +K EIS M + HP Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK---YTVKNEISIMNQLHHPK 109 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRG 149 +I + + K ++ +LEF++GGELFD+I++ + ++ E E Y +Q + + H Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHS 169 Query: 150 VYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + H D+KPEN++ + A +K+ DFGL+ ++ D ++ T T + APE+++ + Sbjct: 170 IVHLDIKPENIMCETKKASSVKIIDFGLAT---KLNPDEIVKVTTATAEFAAPEIVDREP 226 Query: 208 YDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWFSAS--AKKLI 263 G D+W+ GV+ +VL++G PF ED T K EF + S S AK I Sbjct: 227 V-GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFI 285 Query: 264 KRILDPNPATRITFAEVIENEWFK 287 K +L P R+T + +E+ W K Sbjct: 286 KNLLQKEPRKRLTVHDALEHPWLK 309 >5TUR-A nrPDB Length = 404 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 133/267 (49%), Gaps = 21/267 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV-----LKNKMIAQIKREISTMK 84 +Y++G LG G F V V + VAIK ++K+++ L N ++ E+ +K Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG--TRVPMEVVLLK 185 Query: 85 LIKH--PNVIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINA 141 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ A Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 245 Query: 142 VDYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 V +CH+ GV HRD+K EN+L+D N G LK+ DFG AL +D + GT Y P Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL----LKDTVYTDFDGTRVYSPP 301 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E I Y G A +WS G++L+ ++ G +PFE + F+ S+ + Sbjct: 302 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR------VSSECQ 355 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+ L P+ R TF E+ + W + Sbjct: 356 HLIRWCLALRPSDRPTFEEIQNHPWMQ 382 >4AW2-A nrPDB Length = 437 Score = 125 bits (314), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 79/256 (30%), Positives = 136/256 (53%), Gaps = 17/256 (6%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNV-AIKVIDKEKVLKNKMIAQIKREISTM 83 R +E+ + +G G F +V + ++N D V A+K+++K ++LK A + E + Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVK-LKNADKVFAMKILNKWEMLKRAETACFREERDVL 128 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAV 142 + + +Y V+++ GG+L +S RL E+ AR Y +++ A+ Sbjct: 129 VNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT--CGTPNYVAP 200 D H HRD+KP+N+L+D NG ++++DFG S L ++ EDG + ++ GTP+Y++P Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFG-SCL--KLMEDGTVQSSVAVGTPDYISP 245 Query: 201 EVIN----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPPW 254 E++ KG G + D WS GV ++ ++ G PF +L Y KI K F P Sbjct: 246 EILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQ 305 Query: 255 ---FSASAKKLIKRIL 267 S +AK LI+R++ Sbjct: 306 VTDVSENAKDLIRRLI 321 >4RC3-A nrPDB Length = 289 Score = 125 bits (313), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 133/267 (49%), Gaps = 21/267 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV-----LKNKMIAQIKREISTMK 84 +Y++G LG G F V V + VAIK ++K+++ L N ++ E+ +K Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG--TRVPMEVVLLK 70 Query: 85 LIK--HPNVIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINA 141 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ A Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 130 Query: 142 VDYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 V +CH+ GV HRD+K EN+L+D N G LK+ DFG AL +D + GT Y P Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL----LKDTVYTDFDGTRVYSPP 186 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E I Y G A +WS G++L+ ++ G +PFE + F+ S+ + Sbjct: 187 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR------VSSECQ 240 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+ L P+ R TF E+ + W + Sbjct: 241 HLIRWCLALRPSDRPTFEEIQNHPWMQ 267 >3BGP-A nrPDB Length = 333 Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 135/267 (50%), Gaps = 21/267 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV-----LKNKMIAQIKREISTMK 84 +Y++G LG G F V V + VAIK ++K+++ L N ++ E+ +K Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG--TRVPMEVVLLK 114 Query: 85 LIK--HPNVIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINA 141 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ A Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 174 Query: 142 VDYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 V +CH+ GV HRD+K EN+L+D N G LK+ DFG AL +D + GT Y P Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL----LKDTVYTDFDGTRVYSPP 230 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E I Y G A +WS G++L+ ++ G +PFE ++I + + S+ + Sbjct: 231 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQ 284 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+ L P+ R TF E+ + W + Sbjct: 285 HLIRWCLALRPSDRPTFEEIQNHPWMQ 311 >5DBX-A nrPDB Length = 328 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 141/289 (48%), Gaps = 41/289 (14%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YEL +G G A V+ A + VAIK I+ EK + ++ +EI M HPN Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC--QTSMDELLKEIQAMSQCSHPN 70 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKI--------SSNGRLKEDEARKYFQQLINAV 142 V+ + K +++ V++ ++GG + D I NG L+E ++++ + Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 130 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL--------PQQVREDGLLHTTCGT 194 DY H G HRDLK N+LL +G+++++DFG+SA +VR+D + GT Sbjct: 131 DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV-----GT 185 Query: 195 PNYVAPEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 P ++APEV+ +GYD KAD+WS G+ L G P+ + + + PP Sbjct: 186 PCWMAPEVMEQVRGYD-FKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND---PP 241 Query: 254 W-------------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + S +KL+ L +P+ R T AE+++ ++F+K Sbjct: 242 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKA 290 >2XNP-A nrPDB Length = 279 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 79/270 (29%), Positives = 139/270 (51%), Gaps = 16/270 (5%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 +R YE+ T+G G++ + + R +G + K +D + + + + E++ ++ Sbjct: 3 SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEK-QMLVSEVNLLRE 61 Query: 86 IKHPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLI 139 +KHPN++R ++ + +T +Y V+E+ GG+L I+ + L E+ + QL Sbjct: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 140 NAVDYCHSRG-----VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 A+ CH R V HRDLKP N+ LD +K+ DFGL+ + + T GT Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNH--DTSFAKTFVGT 179 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW 254 P Y++PE +N Y+ K+D+WS G +L+ L A PF + L KI + +F P+ Sbjct: 180 PYYMSPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPY 238 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIEN 283 +S ++I R+L+ R + E++EN Sbjct: 239 RYSDELNEIITRMLNLKDYHRPSVEEILEN 268 >3Q53-A nrPDB Length = 306 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 137/261 (52%), Gaps = 10/261 (3%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KY +G+G V A +V G VAI+ ++ ++ K ++I EI M+ K+P Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIIN---EILVMRENKNP 78 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++ + +++ V+E++ GG L D ++ + E + ++ + A+++ HS Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQ 137 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 V HRD+K +N+LL +G++K++DFG A Q E T GTP ++APEV+ K Y Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCA--QITPEQSKRSTMVGTPYWMAPEVVTRKAY- 194 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSN-LTSLYKKIFKA--EFTCPPWFSASAKKLIKRI 266 G K D+WS G++ ++ G P+ + N L +LY E P SA + + R Sbjct: 195 GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 254 Query: 267 LDPNPATRITFAEVIENEWFK 287 L+ + R + E+I++++ K Sbjct: 255 LEMDVEKRGSAKELIQHQFLK 275 >6FD3-A nrPDB Length = 300 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 136/261 (52%), Gaps = 10/261 (3%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KY +G+G V A ++ G VAIK ++ ++ K ++I EI M+ K+P Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN---EILVMRENKNP 79 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N++ + +++ V+E++ GG L D ++ + E + ++ + A+D+ HS Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQ 138 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 V HRD+K +N+LL +G++K++DFG A Q E T GTP ++APEV+ K Y Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCA--QITPEQSKRSTMVGTPYWMAPEVVTRKAY- 195 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSN-LTSLYKKIFKA--EFTCPPWFSASAKKLIKRI 266 G K D+WS G++ ++ G P+ + N L +LY E P SA + + R Sbjct: 196 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 255 Query: 267 LDPNPATRITFAEVIENEWFK 287 L+ + R + E++++ + K Sbjct: 256 LEMDVDRRGSAKELLQHPFLK 276 >5J5T-A nrPDB Length = 370 Score = 120 bits (302), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 127/260 (48%), Gaps = 12/260 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +EL + +G GT+ V ARNV G+ AIKVI K+ + A +++EI MK KHPN Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVI---KLEPGEDFAVVQQEIIMMKDCKHPN 62 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ F + K++ +EF GG L D G L E + ++ + + Y HS+G Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV--INNKGY 208 HRD+K N+LL NG +K++DFG+SA Q GTP ++APEV + KG Sbjct: 123 MHRDIKGANILLTDNGHVKLADFGVSA--QITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW-----FSASAKKLI 263 DLW+ G+ L P D + + K+ F P +S S + Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 240 Query: 264 KRILDPNPATRITFAEVIEN 283 K L NP R T +++++ Sbjct: 241 KMALTKNPKKRPTAEKLLQH 260 >3FXW-A nrPDB Length = 336 Score = 120 bits (302), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 24/237 (10%) Query: 89 PNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAV 142 P+++ + +V + K + ++E + GGELF +I G E EA + + + A+ Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 141 Query: 143 DYCHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + HS + HRD+KPENLL + + LK++DFG + Q L T C TP YVA Sbjct: 142 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ----NALQTPCYTPYYVA 197 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPP 253 PEV+ + YD + D+WS GVI+++L+ G+ PF + ++ ++ + F P Sbjct: 198 PEVLGPEKYDKS-CDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPE 256 Query: 254 W--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSLDDVD 306 W S AK+LI+ +L +P R+T + + + W + P+ A V +D D Sbjct: 257 WSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKD 313 >6CKI-A nrPDB Length = 316 Score = 120 bits (302), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/287 (28%), Positives = 141/287 (49%), Gaps = 41/287 (14%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIRM 94 LGEG A+V+ N+ A+K+I+K+ + +++ RE+ + + H NV+ + Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQP---GHIRSRVFREVEMLYQCQGHRNVLEL 76 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRD 154 E + + Y V E + GG + I E EA Q + +A+D+ H++G+ HRD Sbjct: 77 IEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRD 136 Query: 155 LKPENLLLDAN---GALKVSDFGL--------SALPQQVREDGLLHTTCGTPNYVAPEVI 203 LKPEN+L + +K+ DFGL P E L T CG+ Y+APEV+ Sbjct: 137 LKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPE---LLTPCGSAEYMAPEVV 193 Query: 204 NNKGYDGA----KADLWSCGVILFVLMAGYLPF---------------EDSNLTSLYKKI 244 + + + DLWS GVIL++L++GY PF + L++ I Sbjct: 194 EAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESI 253 Query: 245 FKAEFTCP--PW--FSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + ++ P W S +AK LI ++L + R++ A+V+++ W + Sbjct: 254 QEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >3TKU-A nrPDB Length = 433 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 74/249 (29%), Positives = 130/249 (52%), Gaps = 15/249 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+ + +G G F +V + A+K+++K ++LK A + E + Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 151 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRG 149 + + + +Y V+++ GG+L +S +L ED AR Y +++ A+D H Sbjct: 152 ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH 211 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT--CGTPNYVAPEVI---- 203 HRD+KP+N+LLD NG ++++DFG S L ++ +DG + ++ GTP+Y++PE++ Sbjct: 212 YVHRDIKPDNVLLDVNGHIRLADFG-SCL--KMNDDGTVQSSVAVGTPDYISPEILQAME 268 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPPW---FSAS 258 + G G + D WS GV ++ ++ G PF +L Y KI E F P S Sbjct: 269 DGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEE 328 Query: 259 AKKLIKRIL 267 AK LI+R++ Sbjct: 329 AKDLIQRLI 337 >4AU8-A nrPDB Length = 296 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 140/294 (47%), Gaps = 47/294 (15%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVI----DKEKVLKNKMIAQIKREISTMKL 85 KYE +GEGT+ V A+N E + VA+K + D E V + + REI +K Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-----REICLLKE 61 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVD 143 +KH N++R+ +V+ S K+ V EF + FD S NG L + + + QL+ + Sbjct: 62 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD--SCNGDLDPEIVKSFLFQLLKGLG 119 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEV 202 +CHSR V HRDLKP+NLL++ NG LK++DFGL+ A VR T Y P+V Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR---CYSAEVVTLWYRPPDV 176 Query: 203 INNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLYKKIFK-----AEFTCP---- 252 + D+WS G I L AG F +++ K+IF+ E P Sbjct: 177 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 236 Query: 253 --------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 P +A+ + L++ +L NP RI+ E +++ +F Sbjct: 237 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >3DAK-A nrPDB Length = 290 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 138/284 (48%), Gaps = 31/284 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YEL +G G A V+ A + VAIK I+ EK + + ++ +EI M HPN Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHHPN 69 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISS--------NGRLKEDEARKYFQQLINAV 142 ++ + K +++ V++ ++GG + D I +G L E ++++ + Sbjct: 70 IVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGL 129 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ---QVREDGLLHTTCGTPNYVA 199 +Y H G HRD+K N+LL +G+++++DFG+SA + + + T GTP ++A Sbjct: 130 EYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMA 189 Query: 200 PEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW---- 254 PEV+ +GYD KAD+WS G+ L G P+ + + + PP Sbjct: 190 PEVMEQVRGYD-FKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND---PPSLETG 245 Query: 255 ---------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + S +K+I L +P R T AE++ +++F+K Sbjct: 246 VQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 289 >4KS7-A nrPDB Length = 292 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 78/258 (30%), Positives = 143/258 (55%), Gaps = 20/258 (7%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V AR +G VA+K++D K + +++ E+ M+ +H NV+ M++ Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN---EVVIMRDYQHFNVVEMYK 87 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ ++EF+ GG L D I S RL E++ + ++ A+ Y H++GV HRD+K Sbjct: 88 SYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 157 PENLLLDANGALKVSDFGLSALPQQVRED-GLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 +++LL +G +K+SDFG A Q+ +D + GTP ++APEVI+ Y + D+ Sbjct: 147 SDSILLTLDGRVKLSDFGFCA---QISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDI 202 Query: 216 WSCGVILFVLMAGYLP-FEDSNLTSLYKKIFKAEFTCPPWFSASAK------KLIKRILD 268 WS G+++ ++ G P F DS + ++ K++ + PP S K ++R+L Sbjct: 203 WSLGIMVIEMVDGEPPYFSDSPVQAM-KRLRDSP---PPKLKNSHKVSPVLRDFLERMLV 258 Query: 269 PNPATRITFAEVIENEWF 286 +P R T E++++ + Sbjct: 259 RDPQERATAQELLDHPFL 276 >4FIE-A nrPDB Length = 423 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 136/259 (52%), Gaps = 16/259 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V A +G VA+K +D K + +++ E+ M+ +H NV+ M+ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN---EVVIMRDYQHENVVEMYN 215 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+K Sbjct: 216 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 274 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+W Sbjct: 275 SDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIW 331 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLIKRILDPN 270 S G+++ ++ G P+ + K I PP S S K + R+L + Sbjct: 332 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVRD 388 Query: 271 PATRITFAEVIENEWFKKG 289 PA R T AE++++ + K Sbjct: 389 PAQRATAAELLKHPFLAKA 407 >3ORP-A nrPDB Length = 311 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 126/256 (49%), Gaps = 14/256 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +YELG LG G ++V AR++ + +VA+KV+ + + +RE + HP Sbjct: 13 RYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHP 72 Query: 90 NVIRMFEVMASKTKI----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 ++ +++ ++T Y V+E+V G L D + + G + A + A+++ Sbjct: 73 AIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFS 132 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVIN 204 H G+ HRD+KP N+++ A A+KV DFG++ A+ GT Y++PE Sbjct: 133 HQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQAR 192 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFKAEFTCPP-----WFSAS 258 D A++D++S G +L+ ++ G PF DS ++ Y+ + E PP SA Sbjct: 193 GDSVD-ARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHV--REDPIPPSARHEGLSAD 249 Query: 259 AKKLIKRILDPNPATR 274 ++ + L NP R Sbjct: 250 LDAVVLKALAKNPENR 265 >4JDH-A nrPDB Length = 346 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 136/259 (52%), Gaps = 16/259 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V A +G VA+K +D K + +++ E+ M+ +H NV+ M+ Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN---EVVIMRDYQHENVVEMYN 138 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+K Sbjct: 139 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 197 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+W Sbjct: 198 SDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIW 254 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLIKRILDPN 270 S G+++ ++ G P+ + K I PP S S K + R+L + Sbjct: 255 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVRD 311 Query: 271 PATRITFAEVIENEWFKKG 289 PA R T AE++++ + K Sbjct: 312 PAQRATAAELLKHPFLAKA 330 >2Q0N-A nrPDB Length = 301 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 136/259 (52%), Gaps = 16/259 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V A +G VA+K +D K + +++ E+ M+ +H NV+ M+ Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN---EVVIMRDYQHENVVEMYN 93 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+K Sbjct: 94 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+W Sbjct: 153 SDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIW 209 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLIKRILDPN 270 S G+++ ++ G P+ + K I PP S S K + R+L + Sbjct: 210 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVRD 266 Query: 271 PATRITFAEVIENEWFKKG 289 PA R T AE++++ + K Sbjct: 267 PAQRATAAELLKHPFLAKA 285 >4XBR-A nrPDB Length = 366 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 136/259 (52%), Gaps = 16/259 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V A +G VA+K +D K + +++ E+ M+ +H NV+ M+ Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN---EVVIMRDYQHENVVEMYN 158 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+K Sbjct: 159 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+W Sbjct: 218 SDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIW 274 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLIKRILDPN 270 S G+++ ++ G P+ + K I PP S S K + R+L + Sbjct: 275 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVRD 331 Query: 271 PATRITFAEVIENEWFKKG 289 PA R T AE++++ + K Sbjct: 332 PAQRATAAELLKHPFLAKA 350 >2UV2-A nrPDB Length = 325 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 80/266 (30%), Positives = 140/266 (52%), Gaps = 23/266 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVID--KEKVLKNKMIAQIKREISTMKLIKH 88 +E+ LG+G F KV A+N E A KVID E+ L++ M+ EI + H Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-----EIDILASCDH 93 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHS 147 PN++++ + + ++ ++EF GG + + R L E + + +Q ++A++Y H Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV--REDGLLHTTCGTPNYVAPEVI-- 203 + HRDLK N+L +G +K++DFG+SA + R D + GTP ++APEV+ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFI----GTPYWMAPEVVMC 209 Query: 204 ---NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE---FTCPPWFSA 257 ++ YD KAD+WS G+ L + P + N + KI K+E P +S+ Sbjct: 210 ETSKDRPYD-YKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSS 268 Query: 258 SAKKLIKRILDPNPATRITFAEVIEN 283 + K +K+ L+ N R T ++++++ Sbjct: 269 NFKDFLKKCLEKNVDARWTTSQLLQH 294 >6HXF-B nrPDB Length = 302 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 80/266 (30%), Positives = 139/266 (52%), Gaps = 23/266 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVID--KEKVLKNKMIAQIKREISTMKLIKH 88 +E+ LG+G F KV A+N E G A KVI+ E+ L++ ++ EI + H Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-----EIEILATCDH 75 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHS 147 P ++++ K++ ++EF GG + + R L E + + +Q++ A+++ HS Sbjct: 76 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAPEVI-- 203 + + HRDLK N+L+ G ++++DFG+SA L + D + GTP ++APEV+ Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFI----GTPYWMAPEVVMC 191 Query: 204 ---NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE---FTCPPWFSA 257 + YD KAD+WS G+ L + P + N + KI K++ P +S Sbjct: 192 ETMKDTPYD-YKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSV 250 Query: 258 SAKKLIKRILDPNPATRITFAEVIEN 283 + +K LD NP TR + A+++E+ Sbjct: 251 EFRDFLKIALDKNPETRPSAAQLLEH 276 >2VD5-A nrPDB Length = 412 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 75/265 (28%), Positives = 135/265 (50%), Gaps = 18/265 (6%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + +E+ + +G G F++V + + G A+K+++K +LK ++ + E + Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVD 143 + ++ + +Y V+E+ GG+L +S G R+ + AR Y +++ A+D Sbjct: 117 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT--TCGTPNYVAPE 201 H G HRD+KP+N+LLD G ++++DFG S L ++R DG + + GTP+Y++PE Sbjct: 177 SVHRLGYVHRDIKPDNILLDRCGHIRLADFG-SCL--KLRADGTVRSLVAVGTPDYLSPE 233 Query: 202 VIN------NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI--FKAEFTCP- 252 ++ G G + D W+ GV + + G PF + Y KI +K + P Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 293 Query: 253 --PWFSASAKKLIKRILDPNPATRI 275 A+ I+R+L P P TR+ Sbjct: 294 VDEGVPEEARDFIQRLLCP-PETRL 317 >4BBM-A nrPDB Length = 331 Score = 114 bits (286), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 91/305 (29%), Positives = 142/305 (46%), Gaps = 50/305 (16%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK---NKMIAQIK-REISTMKL 85 KYE +GEG++ V RN + G VAIK K L+ +KM+ +I REI +K Sbjct: 26 KYENLGLVGEGSYGMVMKCRNKDTGRIVAIK-----KFLESDDDKMVKKIAMREIKLLKQ 80 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFD-KISSNGRLKEDEARKYFQQLINAVDY 144 ++H N++ + EV K + Y V EFV L D ++ NG L +KY Q+IN + + Sbjct: 81 LRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG-LDYQVVQKYLFQIINGIGF 139 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGTPNYVAPE 201 CHS + HRD+KPEN+L+ +G +K+ DFG + A P +V +D + T Y APE Sbjct: 140 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEV-----ATRWYRAPE 194 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFKAEFTCP-------- 252 ++ G D+W+ G ++ + G F DS++ LY + P Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 254 Query: 253 ----------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 P S L K+ L +P R AE++ +++F+ Sbjct: 255 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDG 314 Query: 291 KAPKF 295 A +F Sbjct: 315 FAERF 319 >3ZDU-A nrPDB Length = 325 Score = 114 bits (286), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 137/293 (46%), Gaps = 43/293 (14%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YE +GEG++ V ++ G VAIK+ + IA REI +K H N Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAM--REIKFLKQFHHEN 62 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ + EV K KI+ V EF+ L + L+ RKY Q++ A+DY HS + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 151 YHRDLKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRD+KPEN+L+ +G K+ DFG + A P + +D + T Y APE++ Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEV-----ATRWYRAPELVLKDT 177 Query: 208 YDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKIFKAE---------FTCPPWFS 256 G D+W+ G ++ + G YLP S+L L+K + K F+ P F+ Sbjct: 178 SYGKPVDIWALGCMIIEMATGNPYLP-SSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 257 A----------SAKK-----------LIKRILDPNPATRITFAEVIENEWFKK 288 +A+K ++ L +PA RI+ ++++ +E+F + Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >3COM-A nrPDB Length = 314 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 78/264 (29%), Positives = 129/264 (48%), Gaps = 18/264 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ LGEG++ V A + E G VAIK + E L+ +I +EIS M+ P+ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ-----EIIKEISIMQQCDSPH 85 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRG 149 V++ + T ++ V+E+ G + D I N L EDE Q + ++Y H Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 145 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HRD+K N+LL+ G K++DFG++ Q +T GTP ++APEVI GY+ Sbjct: 146 KIHRDIKAGNILLNTEGHAKLADFGVAG--QLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 203 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLI 263 AD+WS G+ + G P+ D + + IF PP F S + + Sbjct: 204 CV-ADIWSLGITAIEMAEGKPPYADIHPM---RAIFMIPTNPPPTFRKPELWSDNFTDFV 259 Query: 264 KRILDPNPATRITFAEVIENEWFK 287 K+ L +P R T +++++ + + Sbjct: 260 KQCLVKSPEQRATATQLLQHPFVR 283 >3LM0-A nrPDB Length = 327 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 82/276 (29%), Positives = 137/276 (49%), Gaps = 23/276 (8%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH-PNVI 92 + LG G FA V+ + G A K + K + ++ A+I EI+ ++L K P VI Sbjct: 34 SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCR-AEILHEIAVLELAKSCPRVI 92 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRGV 150 + EV + ++I +LE+ GGE+F + E++ + +Q++ V Y H + Sbjct: 93 NLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 H DLKP+N+LL + G +K+ DFG+S +++ L GTP Y+APE++N Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMS---RKIGHACELREIMGTPEYLAPEILN--- 206 Query: 208 YD--GAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWFSAS--AKK 261 YD D+W+ G+I ++L+ PF ED+ T L +++ + S S A Sbjct: 207 YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATD 266 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 I+ +L NP R T + + W ++ FEN Sbjct: 267 FIQSLLVKNPEKRPTAEICLSHSWLQQW----DFEN 298 >2F57-A nrPDB Length = 317 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 73/257 (28%), Positives = 134/257 (52%), Gaps = 16/257 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG+ V A G VA+K +D K + +++ E+ M+ H NV+ M+ Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN---EVVIMRDYHHDNVVDMYS 109 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ Y H++GV HRD+K Sbjct: 110 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +++LL ++G +K+SDFG A Q +E + GTP ++APEVI+ Y G + D+W Sbjct: 169 SDSILLTSDGRIKLSDFGFCA--QVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIW 225 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW------FSASAKKLIKRILDPN 270 S G+++ ++ G P+ + ++I + PP S+ + + +L Sbjct: 226 SLGIMVIEMIDGEPPYFNEPPLQAMRRIRD---SLPPRVKDLHKVSSVLRGFLDLMLVRE 282 Query: 271 PATRITFAEVIENEWFK 287 P+ R T E++ + + K Sbjct: 283 PSQRATAQELLGHPFLK 299 >6GU6-A nrPDB Length = 302 Score = 111 bits (278), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 70/218 (32%), Positives = 116/218 (53%), Gaps = 15/218 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEGT+ V R+ G VA+K I E + + + REIS +K ++HPN++ + + Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELRHPNIVSLQD 73 Query: 97 VMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRD 154 V+ +++Y + EF++ + D I + + Y Q++ + +CHSR V HRD Sbjct: 74 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 133 Query: 155 LKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 LKP+NLL+D G +K++DFGL+ +P +V ++ T Y +PEV+ Sbjct: 134 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-----TLWYRSPEVLLGSARYST 188 Query: 212 KADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKA 247 D+WS G I F +A P DS + L+ +IF+A Sbjct: 189 PVDIWSIGTI-FAELATKKPLFHGDSEIDQLF-RIFRA 224 >1TKI-A nrPDB Length = 321 Score = 111 bits (278), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 73/271 (26%), Positives = 132/271 (48%), Gaps = 25/271 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVA-----IKVIDKEKVLKNKMIAQIKREISTMK 84 KY + LG G F V R VE +KV ++VL +K+EIS + Sbjct: 6 KYMIAEDLGRGEFGIVH--RCVETSSKKTYMAKFVKVKGTDQVL-------VKKEISILN 56 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVD 143 + +H N++ + E S ++ + EF++G ++F++I+++ L E E Y Q+ A+ Sbjct: 57 IARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQ 116 Query: 144 YCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 + HS + H D++PEN++ + +K+ +FG + +Q++ P Y APE Sbjct: 117 FLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQA---RQLKPGDNFRLLFTAPEYYAPE 173 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSA 257 V + A D+WS G +++VL++G PF + + I AE+T S Sbjct: 174 VHQHDVVSTA-TDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISI 232 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKK 288 A + R+L +R+T +E +++ W K+ Sbjct: 233 EAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >1V0B-A nrPDB Length = 288 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/291 (30%), Positives = 140/291 (48%), Gaps = 39/291 (13%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KY +GEGT+ V A+N G+ A+K I EK + + REIS +K +KH Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKE-DEGIPSTTIREISILKELKHS 60 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 N++++++V+ +K ++ V E + +L D G L+ A+ + QL+N + YCH Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLD--VCEGGLESVTAKSFLLQLLNGIAYCHD 118 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 R V HRDLKP+NLL++ G LK++DFGL+ A VR+ H T Y AP+V+ Sbjct: 119 RRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRK--YTHEVV-TLWYRAPDVLMGS 175 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKI----------------FK 246 D+WS G I ++ G F E L +++ + + Sbjct: 176 KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYD 235 Query: 247 AEFTC---PPW------FSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 FT PW S L+ ++L +P RIT + +E+ +FK+ Sbjct: 236 PNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4EQM-A nrPDB Length = 294 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 67/221 (30%), Positives = 113/221 (51%), Gaps = 16/221 (7%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI-----DKEKVLKNKMI 73 GS G+ +Y++ LG G + V A + VAIK I +KE+ LK Sbjct: 1 GSHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLK---- 56 Query: 74 AQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARK 133 + +RE+ + H N++ M +V Y V+E++ G L + I S+G L D A Sbjct: 57 -RFEREVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAIN 115 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT--T 191 + Q+++ + + H + HRD+KP+N+L+D+N LK+ DFG++ + + E L T Sbjct: 116 FTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIA---KALSETSLTQTNHV 172 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 GT Y +PE + D D++S G++L+ ++ G PF Sbjct: 173 LGTVQYFSPEQAKGEATDEC-TDIYSIGIVLYEMLVGEPPF 212 >5UUU-A nrPDB Length = 547 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 109/205 (53%), Gaps = 7/205 (3%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK--- 87 + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 259 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ H+ Sbjct: 260 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 319 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 R V +RDLKP N+LLD +G +++SD GL+ + + H + GT Y+APEV+ Sbjct: 320 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQKGV 375 Query: 208 YDGAKADLWSCGVILFVLMAGYLPF 232 + AD +S G +LF L+ G+ PF Sbjct: 376 AYDSSADWFSLGCMLFKLLRGHSPF 400 >4X3F-A nrPDB Length = 337 Score = 109 bits (273), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 127/262 (48%), Gaps = 18/262 (6%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G T G+Y L R + G +V A + G VA+KV+ E + I + + E T Sbjct: 7 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 66 Query: 84 KLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 ++ HP + + + S+ Y V+E V G L + GRL A +Q Sbjct: 67 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 126 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVREDGLLHTTCGT 194 A+ H+ G+ HRD+KP N+L+ G +K++DFG++ A P V + G++ GT Sbjct: 127 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAP--VTQTGMV---MGT 181 Query: 195 PNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFKAEFTCP 252 Y+APE G+D + A D++S GV+ + ++G PF D LT K I + P Sbjct: 182 AQYIAPE--QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP 239 Query: 253 PWFSASAKKLIKRILDPNPATR 274 P + ++LI+ L NPA R Sbjct: 240 PDLPPNVRELIEITLVKNPAMR 261 >3PVW-A nrPDB Length = 695 Score = 109 bits (273), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 109/205 (53%), Gaps = 7/205 (3%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK--- 87 + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ H+ Sbjct: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 R V +RDLKP N+LLD +G +++SD GL+ + + H + GT Y+APEV+ Sbjct: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQKGV 366 Query: 208 YDGAKADLWSCGVILFVLMAGYLPF 232 + AD +S G +LF L+ G+ PF Sbjct: 367 AYDSSADWFSLGCMLFKLLRGHSPF 391 >6E2O-A nrPDB Length = 295 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 79/261 (30%), Positives = 132/261 (50%), Gaps = 15/261 (5%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+GT+ V R++ N +AIK I + ++ + EI+ K +KH N+++ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERD---SRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARK--YFQQLINAVDYCHSRGVYH 152 + I +E V GG L + S G LK++E Y +Q++ + Y H + H Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 153 RDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN--KGYD 209 RD+K +N+L++ +G LK+SDFG S + + T GT Y+APE+I+ +GY Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGI--NPCTETFTGTLQYMAPEIIDKGPRGY- 202 Query: 210 GAKADLWSCGVILFVLMAGYLPFED--SNLTSLYK-KIFKAEFTCPPWFSASAKKLIKRI 266 G AD+WS G + + G PF + +++K +FK P SA AK I + Sbjct: 203 GKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKC 262 Query: 267 LDPNPATRITFAEVIENEWFK 287 +P+P R +++ +E+ K Sbjct: 263 FEPDPDKRACANDLLVDEFLK 283 >4LG4-A nrPDB Length = 299 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 78/264 (29%), Positives = 128/264 (48%), Gaps = 18/264 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ LGEG++ V A + E+G VAIK + E L+ +I +EIS M+ P Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-----EIIKEISIMQQCDSPY 67 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRG 149 V++ + T ++ V+E+ G + D I N L EDE + + ++Y H Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 127 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HR++K N+LL+ G K++DFG++ Q +T GTP ++APEVI GY+ Sbjct: 128 KIHRNIKAGNILLNTEGHAKLADFGVAG--QLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 185 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLI 263 AD+WS G+ + G P+ D + + IF PP F S + Sbjct: 186 CV-ADIWSLGITSIEMAEGKPPYADIHPM---RAIFMIPTNPPPTFRKPELWSDDFTDFV 241 Query: 264 KRILDPNPATRITFAEVIENEWFK 287 K+ L NP R T +++++ + K Sbjct: 242 KKCLVKNPEQRATATQLLQHPFIK 265 >2BPM-A nrPDB Length = 309 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 74/213 (34%), Positives = 115/213 (53%), Gaps = 8/213 (3%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEGT+ V ARN G+ VA+K I + + I REIS +K + HPN++++ + Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 73 Query: 97 VMASKTKIYFVLEFVTGG-ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 V+ ++ K+Y V EF+ + F S+ + + Y QL+ + +CHS V HRDL Sbjct: 74 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 133 Query: 156 KPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 KP+NLL++ GA+K++DFGL+ A VR H T Y APE++ Y D Sbjct: 134 KPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVV-TLWYRAPEILLGCKYYSTAVD 190 Query: 215 LWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFK 246 +WS G I ++ F DS + L+ +IF+ Sbjct: 191 IWSLGCIFAEMVTRRALFPGDSEIDQLF-RIFR 222 >4KRC-A nrPDB Length = 317 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 88/299 (29%), Positives = 134/299 (44%), Gaps = 55/299 (18%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVI--DKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 LG GT+A V N G VA+K + D E+ + I REIS MK +KH N++R+ Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI----REISLMKELKHENIVRL 68 Query: 95 FEVMASKTKIYFVLEFVTGG--ELFDK--ISSNGRLKEDEARKYFQ-QLINAVDYCHSRG 149 ++V+ ++ K+ V EF+ + D + + R E KYFQ QL+ + +CH Sbjct: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL----LHTTCGTPNYVAPEVINN 205 + HRDLKP+NLL++ G LK+ DFGL+ R G+ + T Y AP+V+ Sbjct: 129 ILHRDLKPQNLLINKRGQLKLGDFGLA------RAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL--- 262 D+WSCG IL ++ G F +N K IF T S KL Sbjct: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Query: 263 -----------IKRILDP--------------------NPATRITFAEVIENEWFKKGY 290 ++++L P NP R++ + + + WF + Y Sbjct: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 >6AO5-A nrPDB Length = 362 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 78/266 (29%), Positives = 128/266 (48%), Gaps = 18/266 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ LGEG++ V A + E+G VAIK + E L+ +I +EIS M+ P Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-----EIIKEISIMQQCDSPY 66 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRG 149 V++ + T ++ V+E+ G + D I N L EDE + + ++Y H Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HR++K N+LL+ G K++DFG++ Q +T GTP ++APEVI GY+ Sbjct: 127 KIHRNIKAGNILLNTEGHAKLADFGVAG--QLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------SASAKKLI 263 AD+WS G+ + G P+ D + + IF PP F S + Sbjct: 185 CV-ADIWSLGITSIEMAEGKPPYADIHPM---RAIFMIPTNPPPTFRKPELWSDDFTDFV 240 Query: 264 KRILDPNPATRITFAEVIENEWFKKG 289 K+ L NP R T +++++ + K Sbjct: 241 KKCLVKNPEQRATATQLLQHPFIKNA 266 >4OW8-A nrPDB Length = 283 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 85/286 (29%), Positives = 136/286 (47%), Gaps = 24/286 (8%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G T G+Y L R + G +V A + G VA+KV+ E + I + + E T Sbjct: 6 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 65 Query: 84 KLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 ++ HP + + + S+ Y V+E V G L + GRL A +Q Sbjct: 66 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 125 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVREDGLLHTTCGT 194 A+ H+ G+ HRD+KP N+L+ G +K++DFG++ A P V + G++ GT Sbjct: 126 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAP--VTQTGMV---MGT 180 Query: 195 PNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFKAEFTCP 252 Y+APE G+D + A D++S GV+ + ++G PF D LT K I + P Sbjct: 181 AQYIAPE--QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP 238 Query: 253 PWFSASAKKLIKRILDPNPATRI----TFAEVIENEWFKKGYKAPK 294 P + ++LI+ L NPA R FA+ + + G + P+ Sbjct: 239 PDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAA--VRAGRRPPR 282 >6B2Q-A nrPDB Length = 317 Score = 108 bits (270), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 127/262 (48%), Gaps = 18/262 (6%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G T G+Y L R + G +V A + G VA+KV+ E + I + + E T Sbjct: 27 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 86 Query: 84 KLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 ++ HP + + + S+ Y V+E V G L + GRL A +Q Sbjct: 87 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 146 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVREDGLLHTTCGT 194 A+ H+ G+ HRD+KP N+L+ G +K++DFG++ A P V + G++ GT Sbjct: 147 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAP--VTQTGMV---MGT 201 Query: 195 PNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFKAEFTCP 252 Y+APE G+D + A D++S GV+ + ++G PF D LT K I + P Sbjct: 202 AQYIAPE--QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP 259 Query: 253 PWFSASAKKLIKRILDPNPATR 274 P + ++LI+ L NPA R Sbjct: 260 PDLPPNVRELIEITLVKNPAMR 281 >2XIK-A nrPDB Length = 294 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 133/265 (50%), Gaps = 17/265 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G+G+F +V + + VAIK+ID E+ Q +EI+ + P + R F Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYITRYFG 84 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 TK++ ++E++ GG D + G L+E ++++ +DY HS HRD+K Sbjct: 85 SYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIHRDIK 143 Query: 157 PENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 N+LL G +K++DFG++ Q++ + T GTP ++APEVI YD KAD Sbjct: 144 AANVLLSEQGDVKLADFGVAGQLTDTQIKRN----TFVGTPFWMAPEVIKQSAYD-FKAD 198 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASAKKLIKRILDPN 270 +WS G+ L G P +S+L + + +F PP S K+ ++ L+ + Sbjct: 199 IWSLGITAIELAKGEPP--NSDLHPM-RVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKD 255 Query: 271 PATRITFAEVIENEWFKKGYKAPKF 295 P R T E++++++ + K F Sbjct: 256 PRFRPTAKELLKHKFITRYTKKTSF 280 >4QMW-A nrPDB Length = 310 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 132/261 (50%), Gaps = 17/261 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G+G+F +V + VAIK+ID E+ Q +EI+ + P V + + Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYVTKYYG 94 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 TK++ ++E++ GG D + G L E + ++++ +DY HS HRD+K Sbjct: 95 SYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKIHRDIK 153 Query: 157 PENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 N+LL +G +K++DFG++ Q++ + T GTP ++APEVI YD +KAD Sbjct: 154 AANVLLSEHGEVKLADFGVAGQLTDTQIKRN----TFVGTPFWMAPEVIKQSAYD-SKAD 208 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLIKRILDPN 270 +WS G+ L G P S L + K +F PP +S K+ ++ L+ Sbjct: 209 IWSLGITAIELARGEPPH--SELHPM-KVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE 265 Query: 271 PATRITFAEVIENEWFKKGYK 291 P+ R T E++++++ + K Sbjct: 266 PSFRPTAKELLKHKFILRNAK 286 >4C59-A nrPDB Length = 340 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 86/278 (30%), Positives = 128/278 (46%), Gaps = 38/278 (13%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK-LIKHPNVIR 93 R L EG FA V A++V +G A+K + + KN+ I Q E+ MK L HPN+++ Sbjct: 33 RVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQ---EVCFMKKLSGHPNIVQ 89 Query: 94 MFEVMA--------SKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVD 143 + + + + E G E K+ S G L D K F Q AV Sbjct: 90 FCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 149 Query: 144 YCHSR--GVYHRDLKPENLLLDANGALKVSDFG------------LSALPQQVREDGLLH 189 + H + + HRDLK ENLLL G +K+ DFG SA + + E+ + Sbjct: 150 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 209 Query: 190 TTCGTPNYVAPEVIN--NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA 247 T TP Y PE+I+ + G K D+W+ G IL++L PFED +I Sbjct: 210 NT--TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RIVNG 263 Query: 248 EFTCPPWFSASA--KKLIKRILDPNPATRITFAEVIEN 283 +++ PP + LI+ +L NP R++ AEV+ Sbjct: 264 KYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQ 301 >4U41-A nrPDB Length = 332 Score = 104 bits (260), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 76/241 (31%), Positives = 120/241 (49%), Gaps = 21/241 (8%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 + +P++S S R G +EL +G GT+ +V R+V+ G AIKV+D Sbjct: 3 ANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD---- 58 Query: 68 LKNKMIAQIKREISTMK-LIKHPNVIRMFEVMASKT------KIYFVLEFVTGGELFD-- 118 + +IK EI+ +K H N+ + K+ +++ V+EF G + D Sbjct: 59 VTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLV 118 Query: 119 KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL 178 K + LKED ++++ + + H V HRD+K +N+LL N +K+ DFG+SA Sbjct: 119 KNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSA- 177 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVIN-----NKGYDGAKADLWSCGVILFVLMAGYLPFE 233 Q R G +T GTP ++APEVI + YD ++DLWSCG+ + G P Sbjct: 178 -QLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYD-YRSDLWSCGITAIEMAEGAPPLC 235 Query: 234 D 234 D Sbjct: 236 D 236 >4OTD-A nrPDB Length = 341 Score = 104 bits (260), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 124/247 (50%), Gaps = 7/247 (2%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI---KREISTMKLIKHPNVI 92 LG G F KV + +G+ AIK + K ++ + + KR ++ + HP ++ Sbjct: 19 VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLV 78 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 +F + + FV+E+ GG+L I S+ E A Y ++ + + H + + Sbjct: 79 NLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVY 137 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RDLK +NLLLD G +K++DFGL + + T CGTP ++APEV+ + Y A Sbjct: 138 RDLKLDNLLLDTEGYVKIADFGLCK--EGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRA- 194 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPA 272 D W GV+L+ ++ G PF + ++ I E P + SA A +++R+L NP Sbjct: 195 VDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPE 254 Query: 273 TRITFAE 279 R+ +E Sbjct: 255 RRLGSSE 261 >1UA2-A nrPDB Length = 346 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/238 (32%), Positives = 114/238 (47%), Gaps = 32/238 (13%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID--KEKVLKNKMIAQIKREIST 82 ++R +YE LGEG FA V AR+ VAIK I K+ + REI Sbjct: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFV-TGGELFDKISSNGRLKEDEARKYFQQLINA 141 ++ + HPN+I + + K+ I V +F+ T E+ K +S L + Y + Sbjct: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQG 124 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN----- 196 ++Y H + HRDLKP NLLLD NG LK++DFGL+ + G+PN Sbjct: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-------------KSFGSPNRAYTH 171 Query: 197 ------YVAPEVINNKGYDGAKADLWSCGVIL--FVLMAGYLPFEDSNLTSLYKKIFK 246 Y APE++ G D+W+ G IL +L +LP DS+L L +IF+ Sbjct: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLP-GDSDLDQL-TRIFE 227 >4CRS-A nrPDB Length = 341 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 124/252 (49%), Gaps = 17/252 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI---KREISTMKLIKHPNVI 92 L G F KV A + AIK + K ++ + + KR T+ ++HP ++ Sbjct: 19 VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 78 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 +F +K + FV+E+ GG+L I ++ E A Y ++ + Y H + + Sbjct: 79 NLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVY 137 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH-----TTCGTPNYVAPEVINNKG 207 RDLK +NLLLD G +K++DFGL ++G+ + T CGTP ++APEV+ Sbjct: 138 RDLKLDNLLLDTEGFVKIADFGLC-------KEGMGYGDRTSTFCGTPEFLAPEVLTETS 190 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 Y A D W GV+++ ++ G PF + ++ I E P + S A +++R+L Sbjct: 191 YTRA-VDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 249 Query: 268 DPNPATRITFAE 279 NP R+ +E Sbjct: 250 RRNPERRLGASE 261 >3M42-A nrPDB Length = 299 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 51/278 (18%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST-MKLIKHPNVIR 93 + LG G KV N + A+K++ + +RE+ + + P+++R Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIVR 75 Query: 94 MFEVM----ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCHS 147 + +V A + + V+E + GGELF +I G E EA + + + A+ Y HS Sbjct: 76 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 135 Query: 148 RGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 + HRD+KPENLL + N LK++DFG A E Sbjct: 136 INIAHRDVKPENLLYTSKRPNAILKLTDFGF-----------------------AKETTG 172 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPPW--FS 256 K YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF P W S Sbjct: 173 EK-YDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 230 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 294 K LI+ +L P R+T E + + W + K P+ Sbjct: 231 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 268 >4TNB-A nrPDB Length = 590 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 122/251 (48%), Gaps = 10/251 (3%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG+G F +V + G A K ++K+++ K K + E ++ + V+ + Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHSRGVYH 152 +K + VL + GG+L I + G +E+ A Y +++ ++ H + Sbjct: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVY 309 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RDLKPEN+LLD G +++SD GL+ ++ E L+ GT Y+APEV+NN+ Y G Sbjct: 310 RDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLS 365 Query: 213 ADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 D W G +++ ++ G PF E + +++ + E FS AK + K +L Sbjct: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 Query: 269 PNPATRITFAE 279 + R+ E Sbjct: 426 KDAKQRLGCQE 436 >3PPZ-A nrPDB Length = 309 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 29/265 (10%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G+F V R +G +VA+K++ E+ + + + RE++ MK ++HPN++ Sbjct: 45 IGAGSFGTVH--RAEWHGSDVAVKIL-MEQDFHAERVNEFLREVAIMKRLRHPNIVLFMG 101 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQ--QLINAVDYCHSRG--VY 151 + + V E+++ G L+ + +G R + DE R+ + ++Y H+R + Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIV 161 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 HRDLK NLL+D +KV DFGLS L + GTP ++APEV+ ++ Sbjct: 162 HRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS--KSAAGTPEWMAPEVLRDEP-SNE 218 Query: 212 KADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL-IKRILDPN 270 K+D++S GVIL+ L P+ + N + + F C K+L I R L+P Sbjct: 219 KSDVYSFGVILWELATLQQPWGNLNPAQVVAAV---GFKC--------KRLEIPRNLNPQ 267 Query: 271 PATRITFAEVIENEWFKKGYKAPKF 295 A +IE W + +K P F Sbjct: 268 ------VAAIIEGCWTNEPWKRPSF 286 >1ZXE-A nrPDB Length = 303 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 75/282 (26%), Positives = 133/282 (47%), Gaps = 38/282 (13%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+G F +V ARN + AIK I + + ++ I E+ + + H V+R + Sbjct: 13 VLGQGAFGQVVKARNALDSRYYAIKKIRHTE----EKLSTILSEVMLLASLNHQYVVRYY 68 Query: 96 EV-------------MASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINA 141 + K+ ++ +E+ L+D I S N + DE + F+Q++ A Sbjct: 69 AAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEA 128 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQ----VREDGL--------LH 189 + Y HS+G+ HR+LKP N+ +D + +K+ DFGL+ + ++ D L Sbjct: 129 LSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLT 188 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS-NLTSLYKKIFKAE 248 + GT YVA EV++ G+ K D++S G+I F ++ PF ++ KK+ Sbjct: 189 SAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKKLRSVS 245 Query: 249 FTCPPWFSAS----AKKLIKRILDPNPATRITFAEVIENEWF 286 PP F + KK+I+ ++D +P R ++ + W Sbjct: 246 IEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >5L2Q-C nrPDB Length = 320 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 110/214 (51%), Gaps = 17/214 (7%) Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK----------ISSNGRLKEDEA 131 T ++++ RM + M K +I VL+ + + DK + RL E E Sbjct: 98 TCEIVEDTESSRMVKKM--KKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERET 155 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHT 190 F ++ V+ H + + HRDLK N++L+ + +++F L V E LL Sbjct: 156 VVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGK--HLVSEGDLLKD 213 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT 250 G+P Y++P+V++ + Y G +D+W+ GV+LF ++ G PF DS L++KI AE+T Sbjct: 214 QRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYT 273 Query: 251 CPP--WFSASAKKLIKRILDPNPATRITFAEVIE 282 P S + LI+++L +P R+ A+V+E Sbjct: 274 IPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >4AGU-A nrPDB Length = 311 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 101/203 (49%), Gaps = 11/203 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIK-VIDKEKVLKNKMIAQIKREISTMKLIKH 88 KYE +GEG++ V RN + G VAIK ++ E K IA REI +K +KH Sbjct: 4 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIAL--REIRMLKQLKH 61 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++ + EV K +++ V E+ L + + E + Q + AV++CH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSAL---PQQVREDGLLHTTCGTPNYVAPEVINN 205 HRD+KPEN+L+ + +K+ DFG + L P +D + T Y +PE++ Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEV-----ATRWYRSPELLVG 176 Query: 206 KGYDGAKADLWSCGVILFVLMAG 228 G D+W+ G + L++G Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSG 199 >1CM8-A nrPDB Length = 367 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 91/346 (26%), Positives = 147/346 (42%), Gaps = 58/346 (16%) Query: 15 STPSGSSSGGRTRVGK--------YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEK 66 S P S R V K Y + +G G + V A + G VAIK + + Sbjct: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL--YR 60 Query: 67 VLKNKMIA-QIKREISTMKLIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDK 119 ++++ A + RE+ +K ++H NVI + +V T Y V+ F+ G K Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGK 118 Query: 120 ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP 179 + + +L ED + Q++ + Y H+ G+ HRDLKP NL ++ + LK+ DFGL+ Sbjct: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-- 176 Query: 180 QQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 + D + T Y APEVI N D+WS G I+ ++ G F+ S+ Sbjct: 177 ---QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 Query: 240 LYKKIFKAEFTCPPWF-------------------------------SASAKKLIKRILD 268 K+I K T P F S A L++++L Sbjct: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 Query: 269 PNPATRITFAEVIENEWFKKGYKA---PKFENADVSLDDVDAIFDD 311 + R+T E + + +F+ + P+ + D S DDVD D+ Sbjct: 294 LDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDE 339 >4M7I-A nrPDB Length = 299 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 87/292 (29%), Positives = 136/292 (46%), Gaps = 49/292 (16%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ--IKREISTMKLIKH 88 +E + LG G F V A+N + N AIK I L N+ +A+ + RE+ + ++H Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKALAKLEH 62 Query: 89 PNVIRMF----------EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARK----- 133 P ++R F ++ S K+Y ++ + K NGR +E + Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL-SALPQQVREDGLL---- 188 F Q+ AV++ HS+G+ HRDLKP N+ + +KV DFGL +A+ Q E +L Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 189 ----HT-TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS-----NLT 238 HT GT Y++PE I+ Y K D++S G+ILF L+ PF LT Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELL---YPFSTQMERVRTLT 238 Query: 239 SLYKKIFKAEFTCPPWFS---ASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + F PP F+ +++ +L P+P R +IEN F+ Sbjct: 239 DVRNLKF------PPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFE 284 >2F9G-A nrPDB Length = 353 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 131/302 (43%), Gaps = 49/302 (16%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 ++L LGEG + V A + G+ VAIK I E K + REI +K KH N Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 Query: 91 VIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 +I +F + + ++Y + E + ++ S L +D + + Q + AV Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT--TCGTPNYV----- 198 H V HRDLKP NLL+++N LKV DFGL+ + + D T G YV Sbjct: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 199 -APEVINNKGYDGAKADLWSCGVIL------------------FVLMAGYL--PFEDSNL 237 APEV+ D+WSCG IL +L+ G + P D++L Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 Query: 238 TSLYKKIFKAEFTCPPWFSASAKK------------LIKRILDPNPATRITFAEVIENEW 285 + + P + A+ + L++R+L +PA RIT E +E+ + Sbjct: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 Query: 286 FK 287 + Sbjct: 309 LQ 310 >4FZF-B nrPDB Length = 283 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 73/261 (27%), Positives = 129/261 (49%), Gaps = 17/261 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G+G+F +V + VAIK+ID E+ Q +EI+ + V + + Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSYVTKYYG 73 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 +K++ ++E++ GG D + + G E + ++++ +DY HS HRD+K Sbjct: 74 SYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIK 132 Query: 157 PENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 N+LL G +K++ FG++ Q++ + T GTP ++APEVI YD +KAD Sbjct: 133 AANVLLSEQGDVKLAAFGVAGQLTDTQIKRN----TFVGTPFWMAPEVIQQSAYD-SKAD 187 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLIKRILDPN 270 +WS G+ L G P D + + +F PP F+ S K+ I L+ + Sbjct: 188 IWSLGITAIELAKGEPPNSDMHPMRV---LFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 244 Query: 271 PATRITFAEVIENEWFKKGYK 291 P+ R T E++++++ K K Sbjct: 245 PSFRPTAKELLKHKFIVKNSK 265 >3NIZ-A nrPDB Length = 311 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 83/294 (28%), Positives = 137/294 (46%), Gaps = 46/294 (15%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVI--DKEKVLKNKMIAQIKREISTMKLIK 87 KY+ +GEGT+ V A++ G VA+K I D E + + REIS +K + Sbjct: 22 KYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAED---EGIPSTAIREISLLKELH 77 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYC 145 HPN++ + +V+ S+ + V EF+ K+ + L++ + + Y QL+ V +C Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEKD--LKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVIN 204 H + HRDLKP+NLL++++GALK++DFGL+ A VR H T Y AP+V+ Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVR--SYTHEVV-TLWYRAPDVLM 192 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLY------------------- 241 D+WS G I ++ G F +D L ++ Sbjct: 193 GSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPL 252 Query: 242 --KKIFKAEFTCPPW------FSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 ++ F+ F PW F L+ +L +P RI+ + + + +FK Sbjct: 253 WKQRTFQV-FEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFK 305 >5D7A-A nrPDB Length = 308 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 73/229 (31%), Positives = 114/229 (49%), Gaps = 21/229 (9%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S R G +EL +G GT+ +V R+V+ G AIKV+D + +IK+EI+ Sbjct: 10 SALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEIN 65 Query: 82 TMK-LIKHPNVIRMFEVMASKT------KIYFVLEFVTGGELFDKI--SSNGRLKEDEAR 132 +K H N+ + K +++ V+EF G + D I + LKE+ Sbjct: 66 MLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIA 125 Query: 133 KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC 192 ++++ + + H V HRD+K +N+LL N +K+ DFG+SA Q R G +T Sbjct: 126 YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSA--QLDRTVGRRNTFI 183 Query: 193 GTPNYVAPEVIN-----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSN 236 GTP ++APEVI + YD K+DLWS G+ + G P D + Sbjct: 184 GTPYWMAPEVIACDENPDATYD-FKSDLWSLGITAIEMAEGAPPLCDMH 231 >6DTL-A nrPDB Length = 364 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 65/196 (33%), Positives = 99/196 (50%), Gaps = 12/196 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIRMF 95 +G+G + V A N E ++VAIK I NK+ A + REI ++ + H N++ + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 95 Query: 96 EVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +++ + +Y E + +L I SN L E+ + + Q++ + Y HS V Sbjct: 96 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRDLKP NLLL+AN LK+ DFGL+ + E + T Y APE++ N Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLARV---TSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 211 AKADLWSCGVILFVLM 226 A D+WS G I LM Sbjct: 212 AAIDVWSVGCIFMELM 227 >4UY9-A nrPDB Length = 323 Score = 98.2 bits (243), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 133/270 (49%), Gaps = 32/270 (11%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVI--DKEKVLKNKMIAQIKREISTMKLIKHPN 90 L +G G F KV A + GD VA+K D ++ + ++ I +++E ++KHPN Sbjct: 13 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDI-SQTIENVRQEAKLFAMLKHPN 69 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG- 149 +I + V + + V+EF GG L +++ S R+ D + Q+ ++Y H Sbjct: 70 IIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 150 --VYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + HRDLK N+L+ +N LK++DFGL+ + + + GT ++A Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK----MSAAGTYAWMA 184 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLY-----KKIFKAEFTCPP 253 PEVI + +D+WS GV+L+ L+ G +PF + L Y K TCP Sbjct: 185 PEVIRASMFSKG-SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPE 243 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIEN 283 F+ KL++ +P+P +R +F +++ Sbjct: 244 PFA----KLMEDCWNPDPHSRPSFTNILDQ 269 >3GC0-A nrPDB Length = 329 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 74/237 (31%), Positives = 117/237 (49%), Gaps = 13/237 (5%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S S++ T + +Y LGEGT+ +V A + + VAIK I E + + Sbjct: 23 SVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHE-EEGVPGTAI 81 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 RE+S +K ++H N+I + V+ +++ + E+ +L + N + + + Q Sbjct: 82 REVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQ 140 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGA-----LKVSDFGLS-ALPQQVREDGLLHTT 191 LIN V++CHSR HRDLKP+NLLL + A LK+ DFGL+ A +R+ H Sbjct: 141 LINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQ--FTHEI 198 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKA 247 T Y PE++ + D+WS I +LM L DS + L+ KIF+ Sbjct: 199 I-TLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLF-KIFEV 253 >5H2U-A nrPDB Length = 267 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 125/258 (48%), Gaps = 13/258 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 ++ L R LG G F +V F ++ VAIKVI ++ +L +M+ + EI MK ++H Sbjct: 7 EFTLCRKLGSGYFGEV-FEGLWKDRVQVAIKVISRDNLLHQQML---QSEIQAMKKLRHK 62 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKI--SSNGRLKEDEARKYFQQLINAVDYCHS 147 +++ ++ V++ +Y + E + G L + + S L E Q+ + Y S Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNK 206 + HRDL N+L+ N KV DFGL+ L ++ED L P + APE + ++ Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARL---IKEDVYLSHDHNIPYKWTAPEAL-SR 178 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFED-SNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 G+ K+D+WS G++L + + G +P+ SN + + CP S KL+ Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 265 RILDPNPATRITFAEVIE 282 +P R TF + E Sbjct: 239 TCWCRDPEQRPTFKALRE 256 >6CQF-A nrPDB Length = 297 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 127/261 (48%), Gaps = 12/261 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L + LG GT+ +V AR+ +GD VA+K++ E + ++ +++EI +K +H N Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP---DDDVSTLQKEILILKTCRHAN 74 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ K++ +EF G L D G L E + ++++ + Y HS+ Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 134 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV--INNKGY 208 HRD+K N+L++ G ++++DFG+SA L GTP ++APEV + KG Sbjct: 135 IHRDIKGANILINDAGEVRLADFGISAQIGATLARRL--AFIGTPYWMAPEVAAVALKGG 192 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW-----FSASAKKLI 263 D+WS G+ L P D + + + K+ + P +SA+ I Sbjct: 193 YNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 252 Query: 264 KRILDPNPATRITFAEVIENE 284 K L +P R + +++ ++ Sbjct: 253 KVTLTKSPKKRPSATKMLSHQ 273 >1G3N-A nrPDB Length = 326 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 68/204 (33%), Positives = 106/204 (51%), Gaps = 17/204 (8%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 87 +YE +GEG + KV AR+++NG VA+K + + + + M RE++ ++ ++ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLET 70 Query: 88 --HPNVIRMFEVMA-----SKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQL 138 HPNV+R+F+V +TK+ V E V DK+ G E FQ L Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-L 129 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 + +D+ HS V HRDLKP+N+L+ ++G +K++DFGL+ + L + T Y Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYR 186 Query: 199 APEVINNKGYDGAKADLWSCGVIL 222 APEV+ Y DLWS G I Sbjct: 187 APEVLLQSSY-ATPVDLWSVGCIF 209 >5EFQ-A nrPDB Length = 347 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 104/214 (48%), Gaps = 12/214 (5%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G G+ V K+++ +GEGT+ +V AR+ + G+ VA+K + + + I I R Sbjct: 1 GDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-R 59 Query: 79 EISTMKLIKHPNVIRMFEVMASKTK----------IYFVLEFVTGGELFDKISSNGRLKE 128 EI ++ + H ++I M E++ K Y V E++ + S E Sbjct: 60 EIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNE 119 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + + + +QL+ +DYCH + HRD+K N+LL+ G +K++DFGL+ L E Sbjct: 120 NHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARL-YSSEESRPY 178 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVIL 222 T Y PE++ + D+WSCG IL Sbjct: 179 TNKVITLWYRPPELLLGEERYTPAIDVWSCGCIL 212 >3DTC-A nrPDB Length = 271 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 76/270 (28%), Positives = 131/270 (48%), Gaps = 32/270 (11%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVI--DKEKVLKNKMIAQIKREISTMKLIKHPN 90 L +G G F KV R GD VA+K D ++ + ++ I +++E ++KHPN Sbjct: 11 LEEIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDI-SQTIENVRQEAKLFAMLKHPN 67 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG- 149 +I + V + + V+EF GG L +++ S R+ D + Q+ ++Y H Sbjct: 68 IIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 150 --VYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + HRDLK N+L+ +N LK++DFGL+ + + + G ++A Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK----MSAAGAYAWMA 182 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLY-----KKIFKAEFTCPP 253 PEVI + +D+WS GV+L+ L+ G +PF + L Y K TCP Sbjct: 183 PEVIRASMFSKG-SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPE 241 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIEN 283 F+ KL++ +P+P +R +F +++ Sbjct: 242 PFA----KLMEDCWNPDPHSRPSFTNILDQ 267 >4UYA-A nrPDB Length = 340 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 124/272 (45%), Gaps = 30/272 (11%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKH 88 + EL +G G F +V R G VA+K ++ A+ ++RE +++H Sbjct: 27 RLELKELIGAGGFGQVY--RATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH 84 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+I + V + + VLEF GG L ++ + R+ + Q+ + Y H Sbjct: 85 PNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARGMLYLHEE 143 Query: 149 G---VYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + HRDLK N+LL N LK++DFGL+ + + T G + Sbjct: 144 AFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK----MATAGAYAW 199 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLY-----KKIFKAEFTC 251 +APEVI + + +D+WS GV+L+ L+ G +P+ + L Y K TC Sbjct: 200 MAPEVIKSSLFSKG-SDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTC 258 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 P F+ KL+K +P R +FA ++E Sbjct: 259 PEPFA----KLMKECWQQDPHIRPSFALILEQ 286 >4XEY-B nrPDB Length = 408 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 80/292 (27%), Positives = 137/292 (46%), Gaps = 29/292 (9%) Query: 5 TTPSRSTPSRSTPSGSSSGGRTRVGKYELGRT-------LGEGTFAKVKFARNVENGDNV 57 TT P R+ P+ G K+E+ RT LG G + +V + V Sbjct: 96 TTLHYPAPKRNKPT--VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTV 153 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K + KE ++ + + +E + MK IKHPN++++ V + Y + EF+T G L Sbjct: 154 AVKTL-KEDTME---VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 209 Query: 118 DKISSNGRLKEDEARKYFQ--QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 D + R + + + Q+ +A++Y + HRDL N L+ N +KV+DFGL Sbjct: 210 DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 269 Query: 176 SALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE 233 S L + H P + APE + + K+D+W+ GV+L+ + G P+ Sbjct: 270 SRL--MTGDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYP 326 Query: 234 DSNLTSLY---KKIFKAEFT--CPPWFSASAKKLIKRILDPNPATRITFAEV 280 +L+ +Y +K ++ E CP +L++ NP+ R +FAE+ Sbjct: 327 GIDLSQVYELLEKDYRMERPEGCP----EKVYELMRACWQWNPSDRPSFAEI 374 >4E93-A nrPDB Length = 377 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 118/259 (45%), Gaps = 18/259 (6%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG +G G F +V R DN + V + L + A+ +E +K HPN++ Sbjct: 118 LGEQIGRGNFGEVFSGRL--RADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 175 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHSRGVY 151 R+ V K IY V+E V GG+ + + G RL+ + ++Y S+ Sbjct: 176 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI 235 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TP-NYVAPEVINNKG 207 HRDL N L+ LK+SDFG+S + DG+ + G P + APE +N Sbjct: 236 HRDLAARNCLVTEKNVLKISDFGMS----REEADGVYAASGGLRQVPVKWTAPEALNYGR 291 Query: 208 YDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF---KAEFTCPPWFSASAKKLI 263 Y +++D+WS G++L+ G P+ NL++ + F CP + +L+ Sbjct: 292 YS-SESDVWSFGILLWETFSLGASPY--PNLSNQQTREFVEKGGRLPCPELCPDAVFRLM 348 Query: 264 KRILDPNPATRITFAEVIE 282 ++ P R +F+ + + Sbjct: 349 EQCWAYEPGQRPSFSTIYQ 367 >1K9A-A nrPDB Length = 450 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 78/272 (28%), Positives = 128/272 (47%), Gaps = 28/272 (10%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREI 80 SG + + +L +T+G+G F V G+ VA+K I KN AQ E Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI------KNDATAQAFLAEA 237 Query: 81 STMKLIKHPNVIRMFEVMAS-KTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQ 137 S M ++H N++++ V+ K +Y V E++ G L D + S GR L D K+ Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + A++Y HRDL N+L+ + KVSDFGL+ ++ G L + Sbjct: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-----KW 352 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK-----AEFTC 251 APE + K + K+D+WS G++L+ + + G +P+ L + ++ K A C Sbjct: 353 TAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 PP + ++K + ATR TF ++ E Sbjct: 412 PP----AVYDVMKNCWHLDAATRPTFLQLREQ 439 >4BGQ-A nrPDB Length = 304 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 13/200 (6%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK-REISTMKLI 86 + K+E+ +GEG + V R+ E + VAIK + +N+ + + RE+ ++ + Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE--ENEEVKETTLRELKMLRTL 68 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDY 144 K N++ + E + K+Y V E+V EL +++ NG + ++ + Y QLI A+ + Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NG-VPPEKVKSYIYQLIKAIHW 126 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--DGLLHTTCGTPNYVAPEV 202 CH + HRD+KPENLL+ N LK+ DFG + + + E + T Y +PE+ Sbjct: 127 CHKNDIVHRDIKPENLLISHNDVLKLCDFGFA---RNLSEGNNANYDEEVATRWYRSPEL 183 Query: 203 INNKGYDGAKADLWSCGVIL 222 + Y G D+WS G IL Sbjct: 184 LLGAPY-GKSVDMWSVGCIL 202 >1U5R-A nrPDB Length = 348 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 64/212 (30%), Positives = 106/212 (50%), Gaps = 13/212 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R +G G+F V FAR+V N + VAIK + N+ I +E+ ++ ++HPN I+ Sbjct: 60 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 119 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVYHR 153 + + V+E+ G D + + + L+E E + + Y HS + HR Sbjct: 120 RGCYLREHTAWLVMEYCLGSA-SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHR 178 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI---NNKGYDG 210 D+K N+LL G +K+ DFG +++ ++ GTP ++APEVI + YDG Sbjct: 179 DVKAGNILLSEPGLVKLGDFGSASIMAPA------NSFVGTPYWMAPEVILAMDEGQYDG 232 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSN-LTSLY 241 K D+WS G+ L P + N +++LY Sbjct: 233 -KVDVWSLGITCIELAERKPPLFNMNAMSALY 263 >3QA8-A nrPDB Length = 676 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/228 (30%), Positives = 105/228 (46%), Gaps = 24/228 (10%) Query: 23 GGRT------RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 GGR+ G +E+ LG G F V + + G+ VAIK +E KN+ + Sbjct: 2 GGRSPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNR--ERW 59 Query: 77 KREISTMKLIKHPNVIRMFEV------MASKTKIYFVLEFVTGGEL---FDKISSNGRLK 127 EI MK + HPNV+ EV +A +E+ GG+L ++ + LK Sbjct: 60 CLEIQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLK 119 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL---KVSDFGLSALPQQVRE 184 E R + +A+ Y H + HRDLKPEN++L K+ D G + +++ + Sbjct: 120 EGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYA---KELDQ 176 Query: 185 DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 L GT Y+APE++ K Y D WS G + F + G+ PF Sbjct: 177 GELCTEFVGTLQYLAPELLEQKKYT-VTVDYWSFGTLAFECITGFRPF 223 >2FO0-A nrPDB Length = 495 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 137/292 (46%), Gaps = 29/292 (9%) Query: 5 TTPSRSTPSRSTPSGSSSGGRTRVGKYELGRT-------LGEGTFAKVKFARNVENGDNV 57 TT P R+ P+ G K+E+ RT LG G + +V + V Sbjct: 188 TTLHYPAPKRNKPT--VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTV 245 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K + KE ++ + + +E + MK IKHPN++++ V + Y + EF+T G L Sbjct: 246 AVKTL-KEDTME---VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 301 Query: 118 DKISSNGRLKEDEARKYFQ--QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 D + R + + + Q+ +A++Y + HR+L N L+ N +KV+DFGL Sbjct: 302 DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGL 361 Query: 176 SALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE 233 S L + H P + APE + + K+D+W+ GV+L+ + G P+ Sbjct: 362 SRL--MTGDTYTAHAGAKFPIKWTAPESLAYNKFS-IKSDVWAFGVLLWEIATYGMSPYP 418 Query: 234 DSNLTSLY---KKIFKAEFT--CPPWFSASAKKLIKRILDPNPATRITFAEV 280 +L+ +Y +K ++ E CP +L++ NP+ R +FAE+ Sbjct: 419 GIDLSQVYELLEKDYRMERPEGCP----EKVYELMRACWQWNPSDRPSFAEI 466 >4NST-A nrPDB Length = 351 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 105/212 (49%), Gaps = 12/212 (5%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S G+ V K+++ +GEGT+ +V A++ + G+ VA+K + + + I I REI Sbjct: 5 SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REI 63 Query: 81 STMKLIKHPNVIRMFEVMASKTK----------IYFVLEFVTGGELFDKISSNGRLKEDE 130 ++ + H +V+ M E++ K Y V E++ + S ED Sbjct: 64 KILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDH 123 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT 190 + + +QL+ ++YCH + HRD+K N+LL+ +G +K++DFGL+ L E Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARL-YNSEESRPYTN 182 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVIL 222 T Y PE++ + D+WSCG IL Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCIL 214 >5TQX-A nrPDB Length = 655 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 68/215 (31%), Positives = 103/215 (47%), Gaps = 17/215 (7%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G +E+ LG G F V ++ E +AIK E KN+ + EI MK + H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR--ERWCHEIQIMKKLNH 65 Query: 89 PNVIRMFEVMASKTKI-----YFVLEFVTGGEL---FDKISSNGRLKEDEARKYFQQLIN 140 NV++ +V + +E+ +GG+L +K + LKE + + + Sbjct: 66 ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 141 AVDYCHSRGVYHRDLKPENLLL-DANGAL--KVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + Y H + HRDLKPEN++L D G + K+ D G + + V + L GT Y Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYA---KDVDQGELCTEFVGTLQY 182 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 +APE+ NK Y A D WS G ++F +AGY PF Sbjct: 183 LAPELFENKPYT-ATVDYWSFGTMVFECIAGYRPF 216 >2GCD-A nrPDB Length = 309 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 64/212 (30%), Positives = 106/212 (50%), Gaps = 13/212 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R +G G+F V FAR+V N + VAIK + N+ I +E+ ++ ++HPN I+ Sbjct: 21 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 80 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVYHR 153 + + V+E+ G D + + + L+E E + + Y HS + HR Sbjct: 81 RGCYLREHTAWLVMEYCLGSA-SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHR 139 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI---NNKGYDG 210 D+K N+LL G +K+ DFG +++ ++ GTP ++APEVI + YDG Sbjct: 140 DVKAGNILLSEPGLVKLGDFGSASIMAPA------NSFVGTPYWMAPEVILAMDEGQYDG 193 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSN-LTSLY 241 K D+WS G+ L P + N +++LY Sbjct: 194 -KVDVWSLGITCIELAERKPPLFNMNAMSALY 224 >4E7W-A nrPDB Length = 394 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 88/317 (27%), Positives = 137/317 (43%), Gaps = 80/317 (25%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G R Y + +G G+F V A+ VE+ D VAIK + ++K KN RE+ M Sbjct: 35 GEQREIAYTNCKVIGNGSFGVVFQAKLVES-DEVAIKKVLQDKRFKN-------RELQIM 86 Query: 84 KLIKHPNVIRMFEVMAS----KTKIYF--VLEFVTGGELFDKISSNGRLKEDEA----RK 133 +++KHPNV+ + S K +++ VLE+V ++ +LK+ + Sbjct: 87 RIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPE-TVYRASRHYAKLKQTMPMLLIKL 145 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLD-ANGALKVSDFGLSALPQQVREDGLLHTTC 192 Y QL+ ++ Y HS G+ HRD+KP+NLLLD +G LK+ DFG + + Sbjct: 146 YMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKI-----------LIA 194 Query: 193 GTPN--------YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSL--- 240 G PN Y APE+I D+WS G ++ LM G F +S + L Sbjct: 195 GEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEI 254 Query: 241 -------------------------------YKKIFKAEFTCPPWFSASAKKLIKRILDP 269 + K+F+ P A LI R+L+ Sbjct: 255 IKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFR------PRTPPDAIDLISRLLEY 308 Query: 270 NPATRITFAEVIENEWF 286 P+ R+T E + + +F Sbjct: 309 TPSARLTAIEALCHPFF 325 >3NYO-A nrPDB Length = 576 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 132/268 (49%), Gaps = 21/268 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG+G F +V + G A K ++K+++ K K A E ++ + V+ + Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYH 152 +K + VL + GG+L I G+ EAR F ++ ++ H + + Sbjct: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RDLKPEN+LLD +G +++SD GL+ V E + GT Y+APEV+ N+ Y + Sbjct: 310 RDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFS- 365 Query: 213 ADLWSCGVILFVLMAGYLPFED-------SNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 D W+ G +L+ ++AG PF+ + L K++ E++ FS A+ L + Sbjct: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYS--ERFSPQARSLCSQ 422 Query: 266 ILDPNPATRI-----TFAEVIENEWFKK 288 +L +PA R+ + EV E+ FKK Sbjct: 423 LLCKDPAERLGCRGGSAREVKEHPLFKK 450 >5VO2-A nrPDB Length = 300 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 127/254 (50%), Gaps = 28/254 (11%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 + +G G V R +G+ VA+K K + LK I +++ +KHPN+I Sbjct: 18 QWVGSGAQGAVFLGRF--HGEEVAVK---KVRDLKETDIKHLRK-------LKHPNII-T 64 Query: 95 FEVMASKTKIYFVL-EFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 F+ + ++ Y +L EF G+L++ + + + + + ++Y H + HR Sbjct: 65 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHR 124 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA 213 DLK N+L+ + +K+SDFG S +++ + + GT ++APEVI N+ K Sbjct: 125 DLKSPNMLITYDDVVKISDFGTS---KELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKV 180 Query: 214 DLWSCGVILFVLMAGYLPFEDSNLTSLYKKI------FKAEFTCPPWFSASAKKLIKRIL 267 D+WS GV+L+ L+ G +P++D + +++ + +CP F K L+++ Sbjct: 181 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF----KILLRQCW 236 Query: 268 DPNPATRITFAEVI 281 + P R +F +++ Sbjct: 237 NSKPRNRPSFRQIL 250 >4KIK-B nrPDB Length = 677 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 105/227 (46%), Gaps = 18/227 (7%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S S S G +E+ LG G F V N E G+ +AIK +E +N+ + Sbjct: 8 SWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNR--ERWC 65 Query: 78 REISTMKLIKHPNVIRMFEV------MASKTKIYFVLEFVTGGEL---FDKISSNGRLKE 128 EI M+ + HPNV+ +V +A +E+ GG+L ++ + L+E Sbjct: 66 LEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLRE 125 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVRED 185 + +A+ Y H + HRDLKPEN++L + K+ D G + +++ + Sbjct: 126 GAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYA---KELDQG 182 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 L + GT Y+APE++ + Y D WS G + F + G+ PF Sbjct: 183 SLCTSFVGTLQYLAPELLEQQKY-TVTVDYWSFGTLAFECITGFRPF 228 >6NPU-A nrPDB Length = 298 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 130/273 (47%), Gaps = 27/273 (9%) Query: 24 GRTRVGKYELGRT-------LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 G K+E+ RT LG G + +V + VA+K + KE ++ + + Sbjct: 14 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL-KEDTME---VEEF 69 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 +E + MK IKHPN++++ V + Y + EF+T G L D + R + + + Sbjct: 70 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYM 129 Query: 137 --QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 Q+ +A++Y + HRDL N L+ N +KV+DFGLS L + H Sbjct: 130 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRL--MTGDTYTAHAGAKF 187 Query: 195 P-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLY---KKIFKAEF 249 P + APE + + K+D+W+ GV+L+ + G P+ +L+ +Y +K ++ E Sbjct: 188 PIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 246 Query: 250 T--CPPWFSASAKKLIKRILDPNPATRITFAEV 280 CP +L++ NP+ R +FAE+ Sbjct: 247 PEGCP----EKVYELMRACWQWNPSDRPSFAEI 275 >6DBN-A nrPDB Length = 316 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 122/273 (44%), Gaps = 29/273 (10%) Query: 35 RTLGEGTFAKVKFARNVENGDN----VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 R LGEG F KV+ R GDN VA+K + E IA +K+EI ++ + H N Sbjct: 41 RDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES--GGNHIADLKKEIEILRNLYHEN 98 Query: 91 VIRMFEVMASK--TKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHS 147 +++ + I ++EF+ G L + + N ++ + KY Q+ +DY S Sbjct: 99 IVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGS 158 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY-VAPEVINNK 206 R HRDL N+L+++ +K+ DFGL+ + +E + +P + APE + Sbjct: 159 RQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQS 218 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE-----------------F 249 + A +D+WS GV L L+ Y + S + K I Sbjct: 219 KFYIA-SDVWSFGVTLHELLT-YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRL 276 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 CPP +L+++ + P+ R +F +IE Sbjct: 277 PCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >5AIR-A nrPDB Length = 430 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 88/303 (29%), Positives = 137/303 (45%), Gaps = 53/303 (17%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + Y + +G G+F V A+ ++G+ VAIK + ++K KN RE+ M+ Sbjct: 60 RPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMR 112 Query: 85 LIKHPNVIRMFEVMAS----KTKIYF--VLEFVTGGELFDKISSN-GRLKED----EARK 133 + H N++R+ S K ++Y VL++V E +++ + R K+ + Sbjct: 113 KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKL 170 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTC 192 Y QL ++ Y HS G+ HRD+KP+NLLLD + A LK+ DFG + Q VR + + C Sbjct: 171 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK--QLVRGEPNVSYIC 228 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSLYKKI------- 244 Y APE+I + D+WS G +L L+ G F DS + L + I Sbjct: 229 SR-YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 287 Query: 245 ---------FKAEFTCP-----PW-------FSASAKKLIKRILDPNPATRITFAEVIEN 283 EF P PW A L R+L+ P R+T E + Sbjct: 288 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 347 Query: 284 EWF 286 +F Sbjct: 348 SFF 350 >1BYG-A nrPDB Length = 278 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 128/272 (47%), Gaps = 28/272 (10%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREI 80 SG + + +L +T+G+G F V G+ VA+K I KN AQ E Sbjct: 14 SGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI------KNDATAQAFLAEA 65 Query: 81 STMKLIKHPNVIRMFEVMAS-KTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQ 137 S M ++H N++++ V+ K +Y V E++ G L D + S GR L D K+ Sbjct: 66 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 125 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + A++Y HRDL N+L+ + KVSDFGL+ ++ G L + Sbjct: 126 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-----KW 180 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK-----AEFTC 251 APE + K + K+D+WS G++L+ + + G +P+ L + ++ K A C Sbjct: 181 TAPEALREKKFS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 239 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 PP + +++K + A R +F ++ E Sbjct: 240 PP----AVYEVMKNCWHLDAAMRPSFLQLREQ 267 >5HVK-A nrPDB Length = 315 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 127/266 (47%), Gaps = 26/266 (9%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 G LG+G F + + E G+ + +K + + + +E+ M+ ++HPNV++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHPNVLK 75 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 V+ ++ F+ E++ GG L I S + + + + + + + + Y HS + H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 153 RDLKPENLLLDANGALKVSDFGLSAL--PQQVREDGL----------LHTTCGTPNYVAP 200 R+L N L+ N + V+DFGL+ L ++ + +GL +T G P ++AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMA------GYLPFEDSNLTSLYKKIFKAEFTCPPW 254 E+IN + YD K D++S G++L ++ YLP + L + F + CPP Sbjct: 196 EMINGRSYD-EKVDVFSFGIVLCEIIGRVNADPDYLP--RTMDFGLNVRGFLDRY-CPPN 251 Query: 255 FSASAKKLIKRILDPNPATRITFAEV 280 S + R D +P R +F ++ Sbjct: 252 CPPSFFPITVRCCDLDPEKRPSFVKL 277 >3OHT-A nrPDB Length = 389 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 113/230 (49%), Gaps = 16/230 (6%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIK 87 +Y+ +G G + V + +V++G +A+K + + + ++ K + RE+ +K +K Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAK---RTYRELRLLKHMK 108 Query: 88 HPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 H NVI + +V T + +++ + G +L + I +L +D + Q++ + Sbjct: 109 HENVIGLLDVFTPATSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 167 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE+ Sbjct: 168 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEI 222 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP 252 + N + D+WS G I+ L+ G F ++ + ++I + T P Sbjct: 223 MLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPP 272 >4IC8-A nrPDB Length = 442 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 93/338 (27%), Positives = 139/338 (41%), Gaps = 50/338 (14%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE-KVLKNKMIAQIKREISTMKLIKH 88 +YE+ T+G G + V AR G VAIK I V+ N + RE+ +K KH Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA--KRTLRELKILKHFKH 113 Query: 89 PNVIRMFEVMASKTK------IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+I + +++ +Y VL+ + +L I S+ L + R + QL+ + Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTT-CGTPNYVAP 200 Y HS V HRDLKP NLL++ N LK+ DFG++ L E T T Y AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---------- 250 E++ + DLWS G I ++A F N + I T Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 251 ----------CP-----PWFSA------SAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 P PW + A L+ R+L P+ RI+ A + + + K Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK- 351 Query: 290 YKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGL 327 Y P E D FD + + + L ER +E + Sbjct: 352 YHDPDDE------PDCAPPFDFAFDREALTRERIKEAI 383 >4QTB-A nrPDB Length = 380 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 132/298 (44%), Gaps = 41/298 (13%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y + +GEG + V A + VAIK I + + REI + +H Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE 99 Query: 90 NVIRMFEVMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 NVI + +++ + T + ++++ + +L+ K+ + +L D + Q++ + Y Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYI 158 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED-GLLHTTCGTPNYVAPEV-I 203 HS V HRDLKP NLL++ LK+ DFGL+ + + G L T Y APE+ + Sbjct: 159 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPF---------------------EDSN------ 236 N+KGY + D+WS G IL +++ F ED N Sbjct: 219 NSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 237 ----LTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 L SL K A P + A L+ R+L NP RIT E + + + ++ Y Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 335 >5Z33-A nrPDB Length = 425 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 84/337 (24%), Positives = 153/337 (45%), Gaps = 54/337 (16%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH- 88 +Y + + LG+G + V A N + + VAIK + V K++A KR + +KL++H Sbjct: 32 RYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV--TNVFSKKILA--KRALREIKLLQHF 87 Query: 89 ---PNVIRMFEVMASKTKIY---FVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+ ++++ + + ++ E + +L I S L + + + Q++ + Sbjct: 88 RGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGL 147 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGL----SALPQQVREDGLLHTTCGTPNYV 198 Y HS V HRDLKP NLL++A+ LK+ DFGL S P++ G + T Y Sbjct: 148 KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEE--NAGYMTEYVATRWYR 205 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAG--------YL------------PFEDS--- 235 APE++ + D+WS G IL L+ G Y+ P E++ Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSR 265 Query: 236 -----------NLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENE 284 NL + KK F F P + A L+ R+L +P++RI+ + +E+ Sbjct: 266 IGSPRAQEYVRNLPFMAKKPFPTLF---PNANPDALDLLDRMLAFDPSSRISVEQALEHP 322 Query: 285 WFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVE 321 + + A + + + + +D GE + ++++ Sbjct: 323 YLHIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILD 359 >5HI2-A nrPDB Length = 283 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/267 (23%), Positives = 128/267 (47%), Gaps = 23/267 (8%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G+ +G+ +G G+F V + +GD VA+K++ ++ + K E+ ++ +H Sbjct: 20 GQITVGQRIGSGSFGTV--YKGKWHGD-VAVKMLTPQQ------LQAFKNEVGVLRKTRH 70 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHS 147 N++ +F ++K ++ V ++ G L+ + +S + + + +Q +DY H+ Sbjct: 71 VNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHA 129 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + + HRDLK N+ L + +K+ DFGL+ + + G+ ++APEVI + Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 208 YD--GAKADLWSCGVILFVLMAGYLPFEDSN----------LTSLYKKIFKAEFTCPPWF 255 + ++D+++ G++L+ LM G LP+ + N SL + K CP Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRM 249 Query: 256 SASAKKLIKRILDPNPATRITFAEVIE 282 + +K+ D P+ AE+ E Sbjct: 250 KRLMAECLKKKRDERPSFPRILAEIEE 276 >4ZSG-A nrPDB Length = 347 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 90/338 (26%), Positives = 137/338 (40%), Gaps = 50/338 (14%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE-KVLKNKMIAQIKREISTMKLIKH 88 +YE+ T+G G + V AR G VAIK I V+ N + RE+ +K KH Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA--KRTLRELKILKHFKH 65 Query: 89 PNVIRMFEVMASKT------KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+I + +++ +Y VL+ + +L I S+ L + R + QL+ + Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS--ALPQQVREDGLLHTTCGTPNYVAP 200 Y HS V HRDLKP NLL++ N LK+ DFG++ + T Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---------- 250 E++ + DLWS G I ++A F N + I T Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 251 ----------CP-----PWFSA------SAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 P PW + A L+ R+L P+ RI+ A + + + K Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK- 303 Query: 290 YKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGL 327 Y P E D FD + + + L ER +E + Sbjct: 304 YHDPDDE------PDCAPPFDFAFDREALTRERIKEAI 335 >5G6V-A nrPDB Length = 324 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 72/263 (27%), Positives = 123/263 (46%), Gaps = 34/263 (12%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LGEGT+A V ++ + VA+K I E + RE+S +K +KH N++ + + Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEH--EEGAPCTAIREVSLLKDLKHANIVTLHD 67 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ-QLINAVDYCHSRGVYHRDL 155 ++ ++ + V E++ +L + G + K F QL+ + YCH + V HRDL Sbjct: 68 IIHTEKSLTLVFEYL-DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDL 126 Query: 156 KPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 KP+NLL++ G LK++DFGL+ ++P + ++ ++ T Y P+++ + Sbjct: 127 KPQNLLINERGELKLADFGLARAKSIPTKTYDNEVV-----TLWYRPPDILLGSTDYSTQ 181 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPA 272 D+W G I + + G F S + IF RIL Sbjct: 182 IDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF-------------------RIL--GTP 220 Query: 273 TRITFAEVIENEWFKKGYKAPKF 295 T T+ ++ NE FK Y PK+ Sbjct: 221 TEETWPGILSNEEFKT-YNYPKY 242 >3GC9-A nrPDB Length = 370 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 110/226 (48%), Gaps = 16/226 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 92 R +G G + V A + VA+K + + + ++ + + RE+ +K +KH NVI Sbjct: 34 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR---RTYRELRLLKHLKHENVI 90 Query: 93 RMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 + +V T I +++ + G +L + + S L ++ + QL+ + Y HS Sbjct: 91 GLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQA-LSDEHVQFLVYQLLRGLKYIHS 149 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 G+ HRDLKP N+ ++ + L++ DFGL+ +Q E+ + T Y APE++ N Sbjct: 150 AGIIHRDLKPSNVAVNEDSELRILDFGLA---RQADEE--MTGYVATRWYRAPEIMLNWM 204 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 + D+WS G I+ L+ G F S+ K+I + T P Sbjct: 205 HYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSP 250 >2XYN-A nrPDB Length = 292 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/266 (27%), Positives = 127/266 (47%), Gaps = 27/266 (10%) Query: 30 KYELGRT-------LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 K+E+ RT LG G + +V + VA+K + KE ++ + + +E + Sbjct: 26 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTL-KEDTME---VEEFLKEAAV 81 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ--QLIN 140 MK IKHPN++++ V + Y V E++ G L D + R + + Q+ + Sbjct: 82 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 141 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVA 199 A++Y + HRDL N L+ N +KV+DFGLS L + H P + A Sbjct: 142 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTGDTYTAHAGAKFPIKWTA 199 Query: 200 PEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLY---KKIFKAEFT--CPP 253 PE + + K+D+W+ GV+L+ + G P+ +L+ +Y +K ++ E CPP Sbjct: 200 PESLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 258 Query: 254 WFSASAKKLIKRILDPNPATRITFAE 279 +L++ +PA R +FAE Sbjct: 259 ----KVYELMRACWKWSPADRPSFAE 280 >4LQP-A nrPDB Length = 508 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 43/142 (30%), Positives = 75/142 (52%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 + +G+G F +V+ + + G A+K + K ++ K +A +K E + P V+ + Sbjct: 108 KVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSL 167 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRD 154 + +Y ++EF+ GG+L + ED R Y + I A++ H G HR Sbjct: 168 YYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRA 227 Query: 155 LKPENLLLDANGALKVSDFGLS 176 +KP+N+L+D G +K+SDFGLS Sbjct: 228 IKPDNILIDIRGHIKLSDFGLS 249 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 5/85 (5%) Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 246 + ++T GTP+Y+APE+ +GY G + D WS G I++ + G+ PF Y+KI Sbjct: 319 MAYSTVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN 377 Query: 247 AE----FTCPPWFSASAKKLIKRIL 267 E F S A+ LI+R+L Sbjct: 378 FEQTLQFPDDIHISYEAEDLIRRLL 402 >3C51-A nrPDB Length = 543 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 126/253 (49%), Gaps = 15/253 (5%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG G F +V + G A K ++K+++ K K E + + ++ + Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 95 FEVMASKTKIYFVLEFVTGGEL----FDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +KT + V+ + GG++ ++ N +E A Y Q+++ +++ H R + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQ--QVREDGLLHTTCGTPNYVAPEVINNKGY 208 +RDLKPEN+LLD +G +++SD GL+ + Q + G GTP ++APE++ + Y Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGY----AGTPGFMAPELLLGEEY 366 Query: 209 DGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 D + D ++ GV L+ ++A PF E L +++ + T P FS ++K + Sbjct: 367 DFS-VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCE 425 Query: 265 RILDPNPATRITF 277 +L +P R+ F Sbjct: 426 ALLQKDPEKRLGF 438 >2W96-B nrPDB Length = 306 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 104/204 (50%), Gaps = 18/204 (8%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-- 87 +YE +G G + V AR+ +G VA+K + + I+ + RE++ ++ ++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTV-REVALLRRLEAF 63 Query: 88 -HPNVIRMFEVMAS-----KTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLI 139 HPNV+R+ +V A+ + K+ V E V DK G L + + +Q + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFL 122 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL-PQQVREDGLLHTTCGTPNYV 198 +D+ H+ + HRDLKPEN+L+ + G +K++DFGL+ + Q+ D ++ T Y Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLW----YR 178 Query: 199 APEVINNKGYDGAKADLWSCGVIL 222 APEV+ Y D+WS G I Sbjct: 179 APEVLLQSTY-ATPVDMWSVGCIF 201 >3E7O-A nrPDB Length = 360 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 70/269 (26%), Positives = 127/269 (47%), Gaps = 17/269 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMK 84 T + +Y+ + +G G V A + G NVA+K + + +N+ A + RE+ +K Sbjct: 19 TVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP--FQNQTHAKRAYRELVLLK 76 Query: 85 LIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 + H N+I + V + +Y V+E + L I + L + Q+ Sbjct: 77 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--HMELDHERMSYLLYQM 133 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 + + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ + + ++ T Y Sbjct: 134 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA---RTASTNFMMTPYVVTRYYR 190 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS 258 APEVI GY D+WS G I+ L+ G + F+ ++ + K+ + T F A+ Sbjct: 191 APEVILGMGY-KENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAA 249 Query: 259 AKKLIKRILDPNPATR-ITFAEVIENEWF 286 + ++ ++ PA I F E+ + F Sbjct: 250 LQPTVRNYVENRPAYPGIAFEELFPDWIF 278 >4Y83-A nrPDB Length = 332 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 122/256 (47%), Gaps = 21/256 (8%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 + G F KV A++++ +A K+I ++ + ++ +H N+ ++ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPS--------DVEIQACFRHENIAELYG 132 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + ++ +E GG + +K+ S G ++E E + ++ +D+ HS+ V H D+K Sbjct: 133 AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 192 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC-GTPNYVAPEVINNKGYDGAKADL 215 P N++ + A+ V DFGLS Q+ ED GT Y++PEVI +G+ KAD+ Sbjct: 193 PSNIVFMSTKAVLV-DFGLSV---QMTEDVYFPKDLRGTEIYMSPEVILCRGH-STKADI 247 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKK-IFKAEFTCPPW------FSASAKKLIKRILD 268 +S G L + G P+ S Y ++ PP S ++LI+ L+ Sbjct: 248 YSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLE 307 Query: 269 PNPATRITFAEVIENE 284 NP R A+++++E Sbjct: 308 RNPNHRPRAADLLKHE 323 >5AP3-A nrPDB Length = 313 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 130/280 (46%), Gaps = 35/280 (12%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 Y + + +G G +KV N E AIK ++ E+ N+ + + EI+ + KL +H Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 87 Query: 90 N-VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED------EARKYFQQLINAV 142 + +IR+++ + IY V+E I NG LK+ E + Y++ ++ AV Sbjct: 88 DKIIRLYDYEITDQYIYMVMEC-------GNIDLNGWLKKKKSIDPWERKSYWKNMLEAV 140 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 H G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE Sbjct: 141 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 199 Query: 203 INNKG----------YDGAKADLWSCGVILFVLMAGYLPFED-----SNLTSLYKKIFKA 247 I + K+D+WS G IL+ + G PF+ S L ++ + Sbjct: 200 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 259 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 EF P + ++K L +P RI+ E++ + + + Sbjct: 260 EFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >3MIA-A nrPDB Length = 351 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 104/208 (50%), Gaps = 17/208 (8%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 V KYE +G+GTF +V AR+ + G VA+K + E + I + REI ++L+K Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLK 74 Query: 88 HPNVIRMFEVMASKTK--------IYFVLEFVTGGELFDKISSNGRLK--EDEARKYFQQ 137 H NV+ + E+ +K IY V +F + SN +K E ++ Q Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFTLSEIKRVMQM 132 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGT 194 L+N + Y H + HRD+K N+L+ +G LK++DFGL+ +L + + + + T Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-T 191 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVIL 222 Y PE++ + G DLW G I+ Sbjct: 192 LWYRPPELLLGERDYGPPIDLWGAGCIM 219 >4YHJ-A nrPDB Length = 584 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 72/248 (29%), Positives = 121/248 (48%), Gaps = 12/248 (4%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG+G F +V + G A K + K+++ K K A E ++ ++ V+ + Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYH 152 +K + VL + GG+L I + G DE R F +L ++ + + Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 153 RDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 RDLKPEN+LLD G +++SD GL+ +P+ R G + GT Y+APEV+NN+ Y + Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRV----GTVGYMAPEVVNNEKYTFS 366 Query: 212 KADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 D W G +++ ++ G+ PF E + ++I FS AK + + +L Sbjct: 367 -PDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLL 425 Query: 268 DPNPATRI 275 NP+ R+ Sbjct: 426 TKNPSKRL 433 >4MYG-A nrPDB Length = 372 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 85/341 (24%), Positives = 152/341 (44%), Gaps = 61/341 (17%) Query: 31 YELGRT------LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTM 83 +EL +T +G G + V A + +G+ VAIK + + ++++ A + RE+ + Sbjct: 39 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP--FQSEIFAKRAYRELLLL 96 Query: 84 KLIKHPNVIRMFEVMASKTKI------YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 K ++H NVI + +V + + Y V+ F+ KI E++ + Q Sbjct: 97 KHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQ 153 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 ++ + Y HS GV HRDLKP NL ++ + LK+ DFGL+ D + T Y Sbjct: 154 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-----HADAEMTGYVVTRWY 208 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------EF-- 249 APEVI + + D+WS G I+ ++ G F+ + +I K EF Sbjct: 209 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQ 268 Query: 250 ------------TCP-----------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 + P P S A L++++L+ + R+T A+ + + +F Sbjct: 269 KLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 328 Query: 287 KKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGL 327 + ++ P+ E + FDDS E + L V+ ++ + Sbjct: 329 EP-FRDPEEET------EAQQPFDDSLEHEKLTVDEWKQHI 362 >3HMP-A nrPDB Length = 342 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 138/300 (46%), Gaps = 24/300 (8%) Query: 6 TPSRSTPSRSTPSGSSSGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK 64 +P T S S++ + G+ Y + + +G G +KV N E AIK ++ Sbjct: 32 SPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNL 90 Query: 65 EKVLKNKMIAQIKREISTM-KLIKHPN-VIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 E+ N+ + + EI+ + KL +H + +IR+++ + IY V+E +L + Sbjct: 91 EEA-DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK 148 Query: 123 NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 + E + Y++ ++ AV H G+ H DLKP N L+ +G LK+ DFG++ Q Sbjct: 149 KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD 207 Query: 183 REDGLLHTTCGTPNYVAPEVINNKG----------YDGAKADLWSCGVILFVLMAGYLPF 232 + + GT NY+ PE I + K+D+WS G IL+ + G PF Sbjct: 208 TTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 Query: 233 ED-----SNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + S L ++ + EF P + ++K L +P RI+ E++ + + + Sbjct: 268 QQIINQISKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >4IDT-A nrPDB Length = 356 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 115/254 (45%), Gaps = 22/254 (8%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG G+F +V + + G A+K + E +++A + P ++ ++ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAG--------LTSPRIVPLYG 133 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + + +E + GG L + G L ED A Y Q + ++Y HSR + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 157 PENLLLDANGA-LKVSDFGLSALPQQVREDGL---LHT---TCGTPNYVAPEVINNKGYD 209 +N+LL ++G+ + DFG + ++ DGL L T GT ++APEV+ + D Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVC---LQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD 250 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC---PPWFSASAKKLIKRI 266 AK D+WS ++ ++ G P+ L KI PP + + I+ Sbjct: 251 -AKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEG 309 Query: 267 LDPNPATRITFAEV 280 L P R++ AE+ Sbjct: 310 LRKEPIHRVSAAEL 323 >5ZTN-A nrPDB Length = 429 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 69/217 (31%), Positives = 102/217 (47%), Gaps = 23/217 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +YE+ + +G+G+F +V A + + +VA+K++ EK + Q EI ++ ++ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK----RFHRQAAEEIRILEHLRKQ 153 Query: 90 ------NVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINA 141 NVI M E + I E ++ EL K G RK+ ++ Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG-FSLPLVRKFAHSILQC 212 Query: 142 VDYCHSRGVYHRDLKPENLLLDANG--ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +D H + H DLKPEN+LL G +KV DFG S Q ++T + Y A Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ-----RVYTYIQSRFYRA 267 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGY--LPFED 234 PEVI Y G D+WS G IL L+ GY LP ED Sbjct: 268 PEVILGARY-GMPIDMWSLGCILAELLTGYPLLPGED 303 >2WTK-B nrPDB Length = 373 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 113/235 (48%), Gaps = 15/235 (6%) Query: 29 GKYELGRTLGEG--TFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 G YEL +G+G V AR G+ V ++ I+ E N+M+ ++ E+ KL Sbjct: 9 GCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKLF 67 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDY 144 HPN++ + +++ V F+ G D I ++ + E Q ++ A+DY Sbjct: 68 NHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDF--GLSALP----QQVREDGLLHTTCGTPNYV 198 H G HR +K ++L+ +G + +S LS + Q+V D ++ P ++ Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP-WL 186 Query: 199 APEVI--NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC 251 +PEV+ N +GYD AK+D++S G+ L G++PF+D T + + C Sbjct: 187 SPEVLQQNLQGYD-AKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 240 >4CSV-A nrPDB Length = 275 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 123/259 (47%), Gaps = 22/259 (8%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L R LG G F +V + VA+K + KE + + + +E MK +KHPN++ Sbjct: 15 LERKLGSGQFGEVYEGKWRNYNIEVAVKTL-KEGTMS---VEEFLQEAQIMKKLKHPNLV 70 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKI------SSNGRLKEDEARKYFQQLINAVDYCH 146 +++ V + IY + E+++ G L D + + N + D A Q+ + + Y Sbjct: 71 QLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA----AQVASGMAYLE 126 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TPNYVAPEVIN 204 S+ HRDL N L+ N +KV+DFGL+ L + ED + APE I+ Sbjct: 127 SQNFIHRDLAARNCLVGENNVVKVADFGLARL---INEDEYTARAGAKFPIKWTAPEAIS 183 Query: 205 NKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKL 262 + K+D+W+ G++L+ + G +P+ + + + +++ + P +L Sbjct: 184 YNRFS-IKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYEL 242 Query: 263 IKRILDPNPATRITFAEVI 281 + + + +P R TFAE + Sbjct: 243 MLQCWNKSPEERPTFAETL 261 >5AWM-A nrPDB Length = 394 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 83/329 (25%), Positives = 133/329 (40%), Gaps = 72/329 (21%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 92 R +G G V A + NVAIK + + + V K + RE MKL+ H N+I Sbjct: 50 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK---RAYREFKLMKLVNHKNII 106 Query: 93 RMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 + + +Y V+E + L I + L D Q++ + + H Sbjct: 107 GLLNAFTPQRNLEEFQDVYLVMELMDAN-LCQVIQMD--LDHDRMSYLLYQMLCGIKHLH 163 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCGTPNYVAPEVI 203 S G+ HRDLKP N+++ A+ LK+ DFGL+ R G ++ T Y APEVI Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLA------RTAGTTFMMTPYVVTRYYRAPEVI 217 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF-------- 255 GY D+WS G I+ ++ G + F ++ + KI + T P F Sbjct: 218 LGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 276 Query: 256 -----------------------------------SASAKKLIKRILDPNPATRITFAEV 280 ++ A+ L+ ++L +P RI+ E Sbjct: 277 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 336 Query: 281 IENEWFKKGY-----KAPKFENADVSLDD 304 +++E+ Y AP E D S+D+ Sbjct: 337 LKHEYINVWYDAEEVDAPAPEPYDHSVDE 365 >4EWQ-A nrPDB Length = 383 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 106/224 (47%), Gaps = 16/224 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIK 87 +Y+ +G G + V A + + G VA+K + + + ++ K + RE+ +K +K Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK---RTYRELRLLKHMK 102 Query: 88 HPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 H NVI + +V + +++ + G +L + I +L +D + Q++ + Sbjct: 103 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQILRGL 161 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE+ Sbjct: 162 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEI 216 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 246 + N + D+WS G I+ L+ G F ++ K I + Sbjct: 217 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 260 >5NGU-A nrPDB Length = 381 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 61/192 (31%), Positives = 96/192 (50%), Gaps = 10/192 (5%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG + V A + N VAIK I + + REI + +H N+I + + Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFE--HQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 97 VMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 ++ + T K ++++ + +L+ K+ L D + Q++ + Y HS V H Sbjct: 108 IIRAPTIEQMKDVYIVQDLMETDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLH 166 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVRED-GLLHTTCGTPNYVAPEV-INNKGYDG 210 RDLKP NLLL+ LK+ DFGL+ + + G L T Y APE+ +N+KGY Sbjct: 167 RDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTK 226 Query: 211 AKADLWSCGVIL 222 + D+WS G IL Sbjct: 227 S-IDIWSVGCIL 237 >2PMN-X nrPDB Length = 348 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 132/305 (43%), Gaps = 56/305 (18%) Query: 28 VGKYELGRTLGEGTFAKV-------KF-------------ARNVENGDNVAIKVIDKEKV 67 + Y + RTL +G F K+ KF R+ +N I + K Sbjct: 30 INDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 68 LKNKM--IAQIKREISTMK---LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 KN++ I IK E + + V ++E M + + +L+F + DK + Sbjct: 90 FKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDS----ILKFDEYFFVLDK-NY 144 Query: 123 NGRLKEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQ 181 + + + ++N+ Y H+ + + HRD+KP N+L+D NG +K+SDFG S + Sbjct: 145 TCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGES----E 200 Query: 182 VREDGLLHTTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTS 239 D + + GT ++ PE +N+ Y+GAK D+WS G+ L+V+ +PF +L Sbjct: 201 YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVE 260 Query: 240 LYKKIFKAEFTCP-------------------PWFSASAKKLIKRILDPNPATRITFAEV 280 L+ I P + S +K L NPA RIT + Sbjct: 261 LFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDA 320 Query: 281 IENEW 285 +++EW Sbjct: 321 LKHEW 325 >6GVJ-A nrPDB Length = 429 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 72/274 (26%), Positives = 128/274 (46%), Gaps = 23/274 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 Y + + +G G +KV N E AIK ++ E+ N+ + + EI+ + KL +H Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 203 Query: 90 N-VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 + +IR+++ + IY V+E +L + + E + Y++ ++ AV H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG- 207 G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE I + Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 208 ---------YDGAKADLWSCGVILFVLMAGYLPFED-----SNLTSLYKKIFKAEFTCPP 253 K+D+WS G IL+ + G PF+ S L ++ + EF P Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 381 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + ++K L +P RI+ E++ + + + Sbjct: 382 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >4PWN-A nrPDB Length = 274 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 70/282 (24%), Positives = 134/282 (47%), Gaps = 24/282 (8%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G S+ GR E+GR G+F V + E VA + K+ K++ + K Sbjct: 4 GMSNDGRFLKFDIEIGR----GSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-QRFKE 58 Query: 79 EISTMKLIKHPNVIRMFEVMASKTK----IYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 E +K ++HPN++R ++ S K I V E +T G L + +K R + Sbjct: 59 EAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSW 118 Query: 135 FQQLINAVDYCHSRG--VYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTT 191 +Q++ + + H+R + HRDLK +N+ + G++K+ D GL+ L ++ + Sbjct: 119 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRA---SFAKSV 175 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFT 250 GTP ++APE+ K YD + D+++ G+ + + P+ E N +Y+++ Sbjct: 176 IGTPEFMAPEMYEEK-YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG--V 231 Query: 251 CPPWFSASA----KKLIKRILDPNPATRITFAEVIENEWFKK 288 P F A K++I+ + N R + +++ + +F++ Sbjct: 232 KPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2ZMD-A nrPDB Length = 390 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 23/274 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 Y + + +G G +KV N E AIK ++ E+ N+ + + EI+ + KL +H Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 115 Query: 90 N-VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 + +IR+++ + IY V+E +L + + E + Y++ ++ AV H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG- 207 G+ H DLKP N L+ +G LK+ DFG++ Q + + G NY+ PE I + Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 208 ---------YDGAKADLWSCGVILFVLMAGYLPFED-----SNLTSLYKKIFKAEFTCPP 253 K+D+WS G IL+ + G PF+ S L ++ + EF P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + ++K L +P RI+ E++ + + + Sbjct: 294 --EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >3VN9-A nrPDB Length = 340 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 18/296 (6%) Query: 3 SRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI 62 + +TP R S++ S + + E LG G + V+ R+V +G +A+K I Sbjct: 25 TSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 Query: 63 DKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKI 120 + + + +IS M+ + P + + + + ++ +E + + + ++ Sbjct: 85 RATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV 143 Query: 121 SSNGR-LKEDEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANGALKVSDFGLSAL 178 G+ + ED K ++ A+++ HS+ V HRD+KP N+L++A G +K+ DFG+S Sbjct: 144 IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY 203 Query: 179 PQQVREDGLLHTT-CGTPNYVAPEVI----NNKGYDGAKADLWSCGVILFVLMAGYLPFE 233 D + T G Y+APE I N KGY K+D+WS G+ + L P++ Sbjct: 204 ----LVDSVAKTIDAGCKPYMAPERINPELNQKGY-SVKSDIWSLGITMIELAILRFPYD 258 Query: 234 D--SNLTSLYKKIFKAEFTCPP-WFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 + L + + + P FSA + L N R T+ E++++ +F Sbjct: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >4EBW-A nrPDB Length = 304 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/260 (26%), Positives = 123/260 (47%), Gaps = 17/260 (6%) Query: 30 KYELGRTLGEGTFAKVK--FARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + ELGR +GEG F V + EN +A+ + + + + + +E TM+ Sbjct: 39 RIELGRCIGEGQFGDVHQGIYMSPEN-PALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGEL--FDKISSNGRLKEDEARKYFQQLINAVDYC 145 HP+++++ V+ ++ ++ ++E T GEL F ++ L Y QL A+ Y Sbjct: 98 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYS-LDLASLILYAYQLSTALAYL 155 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEV 202 S+ HRD+ N+L+ +N +K+ DFGLS + ED + ++APE Sbjct: 156 ESKRFVHRDIAARNVLVSSNDCVKLGDFGLS----RYMEDSTYYKASKGKLPIKWMAPES 211 Query: 203 INNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAK 260 IN + + A +D+W GV ++ +LM G PF+ + +I E PP + Sbjct: 212 INFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 270 Query: 261 KLIKRILDPNPATRITFAEV 280 L+ + +P+ R F E+ Sbjct: 271 SLMTKCWAYDPSRRPRFTEL 290 >5HIE-A nrPDB Length = 302 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 128/268 (47%), Gaps = 31/268 (11%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G+ +G+ +G G+F V + +GD VA+K++ ++ + K E+ ++ +H Sbjct: 36 GQITVGQRIGSGSFGTV--YKGKWHGD-VAVKMLTPQQ------LQAFKNEVGVLRKTRH 86 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHS 147 N++ +F ++K ++ V ++ G L+ + + + + +Q +DY H+ Sbjct: 87 VNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI--NN 205 + + HRDLK N+ L + +K+ DFGL+ + + G+ ++APEVI + Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF------------KAEFTCPP 253 K ++D+++ G++L+ LM G LP+ SN+ + + IF K CP Sbjct: 206 KNPYSFQSDVYAFGIVLYELMTGQLPY--SNINNRDQIIFMVGRGYLSPDLSKVRSNCP- 262 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVI 281 + K+L+ L R F +++ Sbjct: 263 ---KAMKRLMAECLKKKRDERPLFPQIL 287 >6O6Q-A nrPDB Length = 335 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 109/211 (51%), Gaps = 26/211 (12%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK-LIKHP 89 YE+ R LG G +++V ++E + V IKV+ K +K K +IKREIS +K L+ P Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVL---KPVKRK---KIKREISILKNLVDGP 96 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKI------SSNGRLKEDEARKYFQQLINAVD 143 N+I M +V+ T G +F+ I S + + R Y +L+ A+D Sbjct: 97 NIIAMLDVVREPQS-------KTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 144 YCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE- 201 Y HS G+ HRD+KP N+++D + L++ D+GL+ E + + + PE Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTE---YNVRVASRYFKGPEL 206 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 +++ + YD + D+WS G +L ++ PF Sbjct: 207 LVDYRLYDYS-LDMWSFGCMLASMVFMKEPF 236 >5IKW-A nrPDB Length = 310 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 88/307 (28%), Positives = 143/307 (46%), Gaps = 51/307 (16%) Query: 28 VGKYE--LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM--IAQIKREISTM 83 VG+++ L +L EG F+ V R G A+K ++ N M + KREI+ M Sbjct: 11 VGRHQVTLEESLAEGGFSTVFLVRT-HGGIRCALK-----RMYVNNMPDLNVCKREITIM 64 Query: 84 K-LIKHPNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLK----EDEARK 133 K L H N++ + + ++ ++E+ G++ +++ N +L+ E E + Sbjct: 65 KELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQM--NKKLQTGFTEPEVLQ 122 Query: 134 YFQQLINAVDYCHS--RGVYHRDLKPENLLLDANGALKVSDFGLSA----LPQQ----VR 183 F AV H + HRDLK EN+LL+ G + DFG + PQ+ V Sbjct: 123 IFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVV 182 Query: 184 EDGLLHTTCGTPNYVAPEVINNKGYD--GAKADLWSCGVILFVLMAGYLPFEDSNLTSLY 241 E+ + T T +Y APE+IN G KAD+W+ G +L+ L LPF +S + Sbjct: 183 EEEIKKYT--TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA--- 237 Query: 242 KKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENAD 299 I FT P +S + LI+ +L+P+P R + F+ Y A KF AD Sbjct: 238 --ICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHR--------PDIFQVSYFAFKFAAAD 287 Query: 300 VSLDDVD 306 + +++ Sbjct: 288 CPVSNIN 294 >5X5O-A nrPDB Length = 310 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/266 (26%), Positives = 117/266 (43%), Gaps = 39/266 (14%) Query: 38 GEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEV 97 G G+F V A+ + VA+K K+LK I++E + ++ H N+I+ + V Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVK-----KLLK------IEKEAEILSVLSHRNIIQFYGV 72 Query: 98 MASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRG---VYH 152 + V E+ + G L+D I+SN + D + + + Y H V H Sbjct: 73 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIH 132 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RDLK N+++ A+G LK+ DFG S L+ GT ++APEVI + Sbjct: 133 RDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV----GTFPWMAPEVIQSLPV-SET 187 Query: 213 ADLWSCGVILFVLMAGYLPFED-SNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNP 271 D +S GV+L+ ++ +PF+ L + + K E R+ P+ Sbjct: 188 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNE----------------RLTIPSS 231 Query: 272 ATRITFAEVIENEWFKKGYKAPKFEN 297 R +FAE++ W K P F+ Sbjct: 232 CPR-SFAELLHQCWEADAKKRPSFKQ 256 >4GS6-A nrPDB Length = 315 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 118/263 (44%), Gaps = 29/263 (11%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 E+ +G G F V A+ +VAIK I+ E K ++ E+ + + HPN+ Sbjct: 12 EVEEVVGRGAFGVVCKAK--WRAKDVAIKQIESESERKAFIV-----ELRQLSRVNHPNI 64 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK---EDEARKYFQQLINAVDYCHS- 147 ++++ A + V+E+ GG L++ + L A + Q V Y HS Sbjct: 65 VKLYG--ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 148 --RGVYHRDLKPENLLLDANG-ALKVSDFGLSALPQQVREDGLLHTTC--GTPNYVAPEV 202 + + HRDLKP NLLL A G LK+ DFG + D H T G+ ++APEV Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAAWMAPEV 175 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK-- 260 Y K D++S G+IL+ ++ PF++ + T PP K Sbjct: 176 FEGSNYS-EKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 234 Query: 261 -KLIKRILDPNPATRITFAEVIE 282 L+ R +P+ R + E+++ Sbjct: 235 ESLMTRCWSKDPSQRPSMEEIVK 257 >5O2C-A nrPDB Length = 380 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/280 (24%), Positives = 130/280 (46%), Gaps = 25/280 (8%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 +S GR ELGR G F V + E VA + K+ K + + K Sbjct: 19 ATSPSGRFLKFDIELGR----GAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKE 73 Query: 79 EISTMKLIKHPNVIRMFE----VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 E +K ++HPN++R ++ ++ K I V E +T G L + +K R + Sbjct: 74 EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSW 133 Query: 135 FQQLINAVDYCHSRG--VYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTT 191 +Q++ + + H+R + HRDLK +N+ + G++K+ D GL+ L + + Sbjct: 134 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT----SFAKSV 189 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFT 250 GTP ++APE+ YD + D+++ G+ + + P+ E N +Y+K+ Sbjct: 190 IGTPEFMAPEMYEEH-YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG--I 245 Query: 251 CPPWFS----ASAKKLIKRILDPNPATRITFAEVIENEWF 286 P F+ K++I+ + N + R++ +++ + +F Sbjct: 246 KPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >5O2B-A nrPDB Length = 285 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 134/284 (47%), Gaps = 30/284 (10%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 ++PSG R K+++ LG G F V + E VA + K+ K + Sbjct: 11 TSPSG-------RFLKFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-Q 60 Query: 75 QIKREISTMKLIKHPNVIRMFE----VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE 130 + K E +K ++HPN++R ++ ++ K I V E +T G L + +K Sbjct: 61 RFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKV 120 Query: 131 ARKYFQQLINAVDYCHSRG--VYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGL 187 R + +Q++ + + H+R + HRDLK +N+ + G++K+ D GL+ L + Sbjct: 121 LRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT----SF 176 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFK 246 + GTP ++APE+ YD + D+++ G+ + + P+ E N +Y+K+ Sbjct: 177 AKSVIGTPEFMAPEMYEEH-YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS 234 Query: 247 AEFTCPPWFS----ASAKKLIKRILDPNPATRITFAEVIENEWF 286 P F+ K++I+ + N + R++ +++ + +F Sbjct: 235 G--IKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >2Y4I-B nrPDB Length = 319 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 109/216 (50%), Gaps = 17/216 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 + E+G +G+G F +V R +G+ VAI++ID E+ ++++ A KRE+ + +H Sbjct: 34 QLEIGELIGKGRFGQVYHGR--WHGE-VAIRLIDIERDNEDQLKA-FKREVMAYRQTRHE 89 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHSR 148 NV+ S + + G L+ + + L ++ R+ Q+++ + Y H++ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGL---SALPQQVREDGLLHTTCGTPNYVAPEVINN 205 G+ H+DLK +N+ D NG + ++DFGL S + Q R + L G ++APE+I Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ 208 Query: 206 KGYD--------GAKADLWSCGVILFVLMAGYLPFE 233 D +D+++ G I + L A PF+ Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >4G3E-A nrPDB Length = 352 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 98/203 (48%), Gaps = 19/203 (9%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G+F +V ++ + G A+K + E +++A + P ++ ++ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAG--------LSSPRIVPLYG 133 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + + +E + GG L I G L ED A Y Q + ++Y H+R + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 157 PENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTC------GTPNYVAPEVINNKGYD 209 +N+LL ++G+ + DFG + ++ DGL + GT ++APEV+ K D Sbjct: 194 ADNVLLSSDGSRAALCDFGHALC---LQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD 250 Query: 210 GAKADLWSCGVILFVLMAGYLPF 232 AK D+WS ++ ++ G P+ Sbjct: 251 -AKVDIWSSCCMMLHMLNGCHPW 272 >4TPT-A nrPDB Length = 303 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/275 (24%), Positives = 123/275 (44%), Gaps = 39/275 (14%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIK-VIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 G LG+G F + + G + +K +I ++ + + ++K M+ + HPNV+ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVK----VMRSLDHPNVL 60 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 + V+ K+ + E++ GG L D + S + ++ + + + + Y HS + H Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL------------------HTTCGT 194 RDL N L+ + + V+DFGLS L + R+ + +T G Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS------LYKKIFKAE 248 P ++APE++N K YD D++S G++L ++ + D + L K+F + Sbjct: 181 PYWMAPEMLNGKSYD-ETVDIFSFGIVLCEIIGQV--YADPDCLPRTLDFGLNVKLFWEK 237 Query: 249 FT---CPPWFSASAKKLIKRILDPNPATRITFAEV 280 F CPP F A + P +R F+++ Sbjct: 238 FVPTDCPPAFFPLAAICCRL----EPESRPAFSKL 268 >4AN9-A nrPDB Length = 301 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/271 (25%), Positives = 121/271 (44%), Gaps = 16/271 (5%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 4 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 61 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 62 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 144 YCHSRG-VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + + HRD+KP N+L+++ G +K+ DFG+S Q + D + + GT +Y++PE Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLI--DEMANEFVGTRSYMSPER 177 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP-----WFSA 257 + Y ++D+WS G+ L + G P + L I PP FS Sbjct: 178 LQGTHYS-VQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEP---PPKLPSAVFSL 233 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKK 288 + + + L NPA R +++ + + K+ Sbjct: 234 EFQDFVNKCLIKNPAERADLKQLMVHAFIKR 264 >4JLC-A nrPDB Length = 657 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 102/217 (47%), Gaps = 23/217 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L LG+G A V R+ + GD A+KV + L+ + RE +K + H N++ Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQM--REFEVLKKLNHKNIV 69 Query: 93 RMFEVMASKTKIY--FVLEFVTGGELFDKIS--SNGR-LKEDEARKYFQQLINAVDYCHS 147 ++F + T + ++EF G L+ + SN L E E + ++ +++ Sbjct: 70 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 129 Query: 148 RGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 G+ HRD+KP N++ D K++DFG + +++ +D + GT Y+ P++ Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMY 186 Query: 204 --------NNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + K Y GA DLWS GV + G LPF Sbjct: 187 ERAVLRKDHQKKY-GATVDLWSVGVTFYHAATGSLPF 222 >2J0K-A nrPDB Length = 656 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/260 (26%), Positives = 122/260 (46%), Gaps = 17/260 (6%) Query: 30 KYELGRTLGEGTFAKVK--FARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + ELGR +GEG F V + EN +A+ + + + + + +E TM+ Sbjct: 391 RIELGRCIGEGQFGDVHQGIYMSPEN-PAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARK--YFQQLINAVDYC 145 HP+++++ V+ ++ ++ ++E T GEL + + D A Y QL A+ Y Sbjct: 450 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVR-KFSLDLASLILYAYQLSTALAYL 507 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEV 202 S+ HRD+ N+L+ A +K+ DFGLS + ED + ++APE Sbjct: 508 ESKRFVHRDIAARNVLVSATDCVKLGDFGLS----RYMEDSTYYKASKGKLPIKWMAPES 563 Query: 203 INNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAK 260 IN + + A +D+W GV ++ +LM G PF+ + +I E PP + Sbjct: 564 INFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 622 Query: 261 KLIKRILDPNPATRITFAEV 280 L+ + +P+ R F E+ Sbjct: 623 SLMTKCWAYDPSRRPRFTEL 642 >3SXS-A nrPDB Length = 268 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 130/257 (50%), Gaps = 16/257 (6%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L + LG G F VK + D VA+K+I + + +++ +E TM + HP ++ Sbjct: 12 LLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDEFF----QEAQTMMKLSHPKLV 66 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVY 151 + + V + + IY V E+++ G L + + S+G+ L+ + + + + + S Sbjct: 67 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 126 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGY 208 HRDL N L+D + +KVSDFG++ + V +D + ++ GT + APEV + Y Sbjct: 127 HRDLAARNCLVDRDLCVKVSDFGMT---RYVLDDQYV-SSVGTKFPVKWSAPEVFHYFKY 182 Query: 209 DGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA-SAKKLIKRI 266 +K+D+W+ G++++ V G +P++ + + K+ + P ++ + +++ Sbjct: 183 -SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSC 241 Query: 267 LDPNPATRITFAEVIEN 283 P R TF +++ + Sbjct: 242 WHELPEKRPTFQQLLSS 258 >4XCU-A nrPDB Length = 300 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 24/269 (8%) Query: 33 LGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 LG+ LGEG F +V A + VA+K++ +K +A + E+ MKL Sbjct: 21 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLADLVSEMEVMKL 78 Query: 86 I-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-------SSNGRLKEDEARKYFQQ 137 I +H N+I + V + +Y ++E G L + + SS G L Q Sbjct: 79 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQ 138 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP 195 + + Y SR HRDL N+L+ + +K++DFGL+ + D T+ G Sbjct: 139 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI--DYYKKTSNGRLPV 196 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPP 253 ++APE + ++ Y ++D+WS G++L+ + G P+ + L+ + + PP Sbjct: 197 KWMAPEALFDRVYT-HQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 255 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIE 282 L++ P+ R TF +++E Sbjct: 256 HCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >4EUU-A nrPDB Length = 319 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 104/219 (47%), Gaps = 23/219 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKN 68 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELF---DKISSNGRLKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ ++ S+ L E E + ++ +++ Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 146 HSRGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HR++KP N++ D K++DFG + +++ +D + GT Y+ P+ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPD 185 Query: 202 VI--------NNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + + K Y GA DLWS GV + G LPF Sbjct: 186 MYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 223 >4EUT-A nrPDB Length = 396 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 103/217 (47%), Gaps = 23/217 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L LG+G A V R+ + GD AIKV + L+ + RE +K + H N++ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIV 70 Query: 93 RMFEVMASKTKIY--FVLEFVTGGELF---DKISSNGRLKEDEARKYFQQLINAVDYCHS 147 ++F + T + ++EF G L+ ++ S+ L E E + ++ +++ Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 148 RGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 G+ HR++KP N++ D K++DFG + +++ +D + GT Y+ P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMY 187 Query: 204 --------NNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + K Y GA DLWS GV + G LPF Sbjct: 188 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 223 >4YFF-A nrPDB Length = 311 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 74/277 (26%), Positives = 121/277 (43%), Gaps = 23/277 (8%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 +G S ++ + E +G G+F KV R VAIK + Sbjct: 31 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRC--RNKIVAIKRYRANTYCSKSDVDMFC 88 Query: 78 REISTMKLIKHPNVIRMF-EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 RE+S + + HP VI+ + ++ V ++++GG LF + R+ + +++ Sbjct: 89 REVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSK---- 144 Query: 137 QLINAVD------YCH--SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 LI AVD Y H ++ + HRDL N+LL +G V+DFG S Q + ED + Sbjct: 145 -LIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMT 203 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 G ++APEV KAD++S + L+ ++ G +PF ++L A Sbjct: 204 KQP-GNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF--AHLKPAAAAADMAY 260 Query: 249 FTCPPWFSASAKKLIKRIL----DPNPATRITFAEVI 281 P S K I +L + P R F+EV+ Sbjct: 261 HHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVV 297 >6NT9-A nrPDB Length = 742 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 103/217 (47%), Gaps = 23/217 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L LG+G A V R+ + GD AIKV + L+ + RE +K + H N++ Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIV 68 Query: 93 RMFEVMASKTKIY--FVLEFVTGGELF---DKISSNGRLKEDEARKYFQQLINAVDYCHS 147 ++F + T + ++EF G L+ ++ S+ L E E + ++ +++ Sbjct: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 Query: 148 RGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 G+ HR++KP N++ D K++DFG + +++ +D + GT Y+ P++ Sbjct: 129 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVSLYGTEEYLHPDMY 185 Query: 204 --------NNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + K Y GA DLWS GV + G LPF Sbjct: 186 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 221 >5TE0-A nrPDB Length = 347 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 94/320 (29%), Positives = 141/320 (44%), Gaps = 55/320 (17%) Query: 18 SGSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 SG SG RV + +GR L EG FA V R NG A+K + N Sbjct: 3 SGLGSGYIGRV--FGIGRQQVTVDEVLAEGGFAIVFLVRT-SNGMKCALK----RMFVNN 55 Query: 71 KMIAQI-KREISTMK-LIKHPNVIRMFEVMASKT------KIYFVLEFVTGGELFDKISS 122 + Q+ KREI M+ L H N++ + + ++ +++F GG++ + + Sbjct: 56 EHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLM-- 113 Query: 123 NGRLK----EDEARKYFQQLINAVDYCHS--RGVYHRDLKPENLLLDANGALKVSDFGLS 176 N RL+ E+E + F AV H + HRDLK EN+LL G + DFG + Sbjct: 114 NQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSA 173 Query: 177 A----LPQ----QVREDGLLHTTCGTPNYVAPEVINNKGYDG----AKADLWSCGVILFV 224 PQ ED + T T +Y APE++N Y G KAD+W+ G +L+ Sbjct: 174 TNKFQNPQTEGVNAVEDEIKKYT--TLSYRAPEMVN--LYSGKIITTKADIWALGCLLYK 229 Query: 225 LMAGYLPFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEV-- 280 L LPF +S + I FT P +S LI+ +L+P+P R +V Sbjct: 230 LCYFTLPFGESQVA-----ICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSY 284 Query: 281 IENEWFKKGYKAPKFENADV 300 + KK P +N+ + Sbjct: 285 FSFKLLKKECPIPNVQNSPI 304 >3UIU-A nrPDB Length = 306 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/187 (33%), Positives = 93/187 (49%), Gaps = 15/187 (8%) Query: 100 SKTKIYFV-LEFVTGGELFDKISSNGRLKEDE--ARKYFQQLINAVDYCHSRGVYHRDLK 156 SKTK F+ +EF G L I K D+ A + F+Q+ VDY HS+ + HRDLK Sbjct: 104 SKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLK 163 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 P N+ L +K+ DFGL ++ DG + GT Y++PE I+++ Y G + DL+ Sbjct: 164 PSNIFLVDTKQVKIGDFGLVT---SLKNDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLY 219 Query: 217 SCGVILF-VLMAGYLPFEDSN-LTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATR 274 + G+IL +L FE S T L I F K L++++L P R Sbjct: 220 ALGLILAELLHVCDTAFETSKFFTDLRDGII------SDIFDKKEKTLLQKLLSKKPEDR 273 Query: 275 ITFAEVI 281 +E++ Sbjct: 274 PNTSEIL 280 >2A1A-B nrPDB Length = 284 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 122/265 (46%), Gaps = 37/265 (13%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM-- 94 +G G F +V A++ +G IK +V N A+ RE+ + + H N++ Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIK-----RVKYNNEKAE--REVKALAKLDHVNIVHYNG 71 Query: 95 ----FEV---------MASKTKIYFV-LEFVTGGELFDKISSNGRLKEDE--ARKYFQQL 138 F+ SKTK F+ +EF G L I K D+ A + F+Q+ Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQI 131 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 VDY HS+ + +RDLKP N+ L +K+ DFGL ++ DG + GT Y+ Sbjct: 132 TKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVT---SLKNDGKRTRSKGTLRYM 188 Query: 199 APEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSN-LTSLYKKIFKAEFTCPPWFS 256 +PE I+++ Y G + DL++ G+IL +L FE S T L I F Sbjct: 189 SPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGII------SDIFD 241 Query: 257 ASAKKLIKRILDPNPATRITFAEVI 281 K L++++L P R +E++ Sbjct: 242 KKEKTLLQKLLSKKPEDRPNTSEIL 266 >3OZ6-A nrPDB Length = 388 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/245 (29%), Positives = 117/245 (47%), Gaps = 29/245 (11%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK-REISTM 83 R + KYEL + LG+G + V + + G+ VA+K I +N AQ REI + Sbjct: 5 RHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKI--FDAFQNSTDAQRTFREIMIL 62 Query: 84 -KLIKHPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYF-QQLI 139 +L H N++ + V+ + +Y V +++ +L I +N + E ++Y QLI Sbjct: 63 TELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRAN--ILEPVHKQYVVYQLI 119 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA-----------LPQQVREDG-- 186 + Y HS G+ HRD+KP N+LL+A +KV+DFGLS +P + E+ Sbjct: 120 KVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTEN 179 Query: 187 ------LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 +L T Y APE++ D+WS G IL ++ G F S+ + Sbjct: 180 FDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 241 YKKIF 245 ++I Sbjct: 240 LERII 244 >3FME-A nrPDB Length = 290 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 126/263 (47%), Gaps = 20/263 (7%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG G + V+ R+V +G +A+K I + + + +IS M+ + P + + Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 73 Query: 97 VMASKTKIYFVLEFV--TGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSR-GVYH 152 + + ++ +E + + + + ++ G+ + ED K ++ A+++ HS+ V H Sbjct: 74 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 133 Query: 153 RDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCGTPNYVAPEVI----NNKG 207 RD+KP N+L++A G +K+ DFG+S L V +D G Y+APE I N KG Sbjct: 134 RDVKPSNVLINALGQVKMCDFGISGYLVDDVAKD----IDAGCKPYMAPERINPELNQKG 189 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLI 263 Y K+D+WS G+ + L P+ DS T + E P FSA Sbjct: 190 Y-SVKSDIWSLGITMIELAILRFPY-DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 247 Query: 264 KRILDPNPATRITFAEVIENEWF 286 + L N R T+ E++++ +F Sbjct: 248 SQCLKKNSKERPTYPELMQHPFF 270 >4NEU-A nrPDB Length = 333 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 102/220 (46%), Gaps = 25/220 (11%) Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E M ++H V+++ V+ + K V+E++ G L + + + ++ Sbjct: 72 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEI 131 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP----------QQVRE-DGL 187 I + Y H +GV H+DLKPEN+L+D + +K++D GL++ ++RE DG Sbjct: 132 IEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT 191 Query: 188 LHTTCGTPNYVAPEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 246 GT Y+APE +N+ K+D++S V+L+ + A P+E++ K Sbjct: 192 AKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIK 251 Query: 247 A-------EFT--CPPWFSASAKKLIKRILDPNPATRITF 277 + + T CP L+K + NP R TF Sbjct: 252 SGNRPDVDDITEYCP----REIISLMKLCWEANPEARPTF 287 >1JNK-A nrPDB Length = 423 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 124/274 (45%), Gaps = 27/274 (9%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMK 84 T + +Y+ + +G G V A + NVAIK + + +N+ A + RE+ MK Sbjct: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMK 116 Query: 85 LIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--Q 136 + H N+I + V + +Y V+E + + +++ D R + Sbjct: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLY 171 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCG 193 Q++ + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ R G ++ Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA------RTAGTSFMMTPYVV 225 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 T Y APEVI GY D+WS G I+ ++ + F + + K+ + T P Sbjct: 226 TRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Query: 254 WFSASAKKLIKRILDPNPATR-ITFAEVIENEWF 286 F + ++ ++ P +TF ++ + F Sbjct: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLF 318 >6O8B-A nrPDB Length = 665 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 102/217 (47%), Gaps = 23/217 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L LG+G A V R+ + GD AIKV + L+ + RE +K + H N++ Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM--REFEVLKKLNHKNIV 76 Query: 93 RMFEVMASKTKIY--FVLEFVTGGELF---DKISSNGRLKEDEARKYFQQLINAVDYCHS 147 ++F + T + ++EF G L+ ++ S+ L E E + ++ +++ Sbjct: 77 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 136 Query: 148 RGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 G+ HR++KP N++ D K++DFG + +++ +D GT Y+ P++ Sbjct: 137 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAA---RELEDDEQFVELYGTEEYLHPDMY 193 Query: 204 --------NNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + K Y GA DLWS GV + G LPF Sbjct: 194 ERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF 229 >5VD3-A nrPDB Length = 311 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 116/245 (47%), Gaps = 16/245 (6%) Query: 37 LGEGTFAKVKFARNVENGDNVAIK-VIDKEKVLKNKM--IAQIKREISTMKLIKHPNVIR 93 LG G++ +V R+ E+G A+K + + K++ +A++ S K+ +HP +R Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG---SHEKVGQHPCCVR 121 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHSRGVYH 152 + + +Y E + G L + G L E + Y + + A+ + HS+G+ H Sbjct: 122 LEQAWEEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVH 180 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 D+KP N+ L G K+ DFGL ++ G G P Y+APE++ +G G Sbjct: 181 LDVKPANIFLGPRGRCKLGDFGLLV---ELGTAGAGEVQEGDPRYMAPELL--QGSYGTA 235 Query: 213 ADLWSCGV-ILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNP 271 AD++S G+ IL V LP L + EFT S+ + ++ +L+P+P Sbjct: 236 ADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTA--GLSSELRSVLVMMLEPDP 293 Query: 272 ATRIT 276 R T Sbjct: 294 KLRAT 298 >5O0Y-A nrPDB Length = 579 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 102/223 (45%), Gaps = 20/223 (8%) Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYF-VLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 RE K + HP ++++++ + T + VLE+ G +L + + + E EAR Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIM 396 Query: 137 QLINAVDYCHS--RGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVRE---DGLL 188 Q++NA+ Y + + H DLKP N+LL A G +K++DFGLS + DG+ Sbjct: 397 QIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGME 456 Query: 189 HTT--CGTPNYVAPEVI---NNKGYDGAKADLWSCGVILFVLMAGYLPF------EDSNL 237 T+ GT Y+ PE K D+WS GVI + + G PF +D Sbjct: 457 LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ 516 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 + K + +F P + AK I+R L RI ++ Sbjct: 517 ENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL 559 >4H1J-A nrPDB Length = 293 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 128/278 (46%), Gaps = 24/278 (8%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVK---FARNVENGDNVAIKVIDKEKVLKNKM 72 P GS G R L R LGEG F +V + + NVA+K K+ L NK Sbjct: 12 VPRGSPQYGIAR-EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK- 69 Query: 73 IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEA 131 + E MK + HP+++++ ++ + + ++E GEL + N LK Sbjct: 70 -EKFMSEAVIMKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTL 127 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 Y Q+ A+ Y S HRD+ N+L+ + +K+ DFGLS + ED + Sbjct: 128 VLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIED--EDYYKASV 185 Query: 192 CGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPF---EDSNLTSLYKK--- 243 P +++PE IN + + A +D+W V ++ +L G PF E+ ++ + +K Sbjct: 186 TRLPIKWMSPESINFRRFTTA-SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDR 244 Query: 244 IFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + K + CPP L+ R D +P+ R F E++ Sbjct: 245 LPKPDL-CPP----VLYTLMTRCWDYDPSDRPRFTELV 277 >2XS0-A nrPDB Length = 386 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 119/258 (46%), Gaps = 26/258 (10%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMK 84 T + +Y+ + +G G V A + NVAIK + + +N+ A + RE+ MK Sbjct: 23 TVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP--FQNQTHAKRAYRELVLMK 80 Query: 85 LIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--Q 136 + H N+I + V + +Y V+E + + +++ D R + Sbjct: 81 CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDAN-----LCQVIQMELDHERMSYLLY 135 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCG 193 Q++ + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ R G ++ Sbjct: 136 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA------RTAGTSFMMVPFVV 189 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 T Y APEVI GY D+WS G I+ ++ G + F ++ + K+ + T P Sbjct: 190 TRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCP 248 Query: 254 WFSASAKKLIKRILDPNP 271 F + ++ ++ P Sbjct: 249 EFMKKLQPTVRTYVENRP 266 >3FI2-A nrPDB Length = 353 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 124/274 (45%), Gaps = 27/274 (9%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMK 84 T + +Y+ + +G G V A + NVAIK + + +N+ A + RE+ MK Sbjct: 21 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMK 78 Query: 85 LIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--Q 136 + H N+I + V + +Y V+E + + +++ D R + Sbjct: 79 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLY 133 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCG 193 Q++ + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ R G ++ Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA------RTAGTSFMMTPYVV 187 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 T Y APEVI GY D+WS G I+ ++ + F + + K+ + T P Sbjct: 188 TRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 246 Query: 254 WFSASAKKLIKRILDPNPATR-ITFAEVIENEWF 286 F + ++ ++ P +TF ++ + F Sbjct: 247 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLF 280 >4QNY-A nrPDB Length = 354 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 91/341 (26%), Positives = 155/341 (45%), Gaps = 53/341 (15%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y L R +G G++ V AR+ ++ + VA+K ++KE + + +I REI + Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFND 80 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 N+I + ++ + Y V++ + +L + S L E + + Q + A+ Sbjct: 81 DNIIGLRNILTPEDPENFDHFYIVMD-IMETDLKQVLRSGQELTEAHIQFFIYQALRALH 139 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN-YVAPE- 201 HS GV HRD+ P N+L++ N LK+ DFGL+ ++ + G T T Y APE Sbjct: 140 IIHSAGVIHRDITPANILVNTNCDLKICDFGLA---KEENDQGEYMTDYVTMRWYRAPEL 196 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPF---------------------EDSNL--T 238 V+ +K Y A+ D+W G IL L+ F ED N + Sbjct: 197 VMEDKDY-SAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 239 SLYKKIFKAEFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 S +K K + P P S A L++ +L NP RIT + + + + ++ + Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLH 315 Query: 291 KAPKFENADVSLDDVDAIFDDSGESKNLVVERR---EEGLK 328 ++AD +L FD++ E K +V +R EE +K Sbjct: 316 -----DDADDNLSYALFRFDEN-EQKTIVDVKRAIYEESVK 350 >5Y86-A nrPDB Length = 588 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 103/217 (47%), Gaps = 23/217 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN------KMIAQIKREISTM 83 +YE+ + +G+G+F +V + + VA+K++ EK +++ +K++ T Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINA 141 + NVI M E + + E ++ +L++ I N RK+ Q ++ + Sbjct: 268 SM----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 142 VDYCHSRGVYHRDLKPENLLLDANG--ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +D H + H DLKPEN+LL +G + KV DFG S Q L+T + Y A Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK-----LYTYIQSRFYRA 377 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAG--YLPFED 234 PE+I Y D+WS G IL L+ G P ED Sbjct: 378 PEIILGSRYS-TPIDIWSFGCILAELLTGQPLFPGED 413 >6DBM-A nrPDB Length = 318 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 104/205 (50%), Gaps = 23/205 (11%) Query: 35 RTLGEGTFAKVKF----ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 R LGEG F KV N G+ VA+K + + +++ + K+EI ++ + H + Sbjct: 37 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR--SGWKQEIDILRTLYHEH 94 Query: 91 VIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 +I+ A + V+E+V G L D + + + + + QQ+ + Y HS+ Sbjct: 95 IIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHSQ 153 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLS-ALPQ-----QVREDGLLHTTCGTPNY-VAPE 201 HRDL N+LLD + +K+ DFGL+ A+P+ +VREDG +P + APE Sbjct: 154 HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG------DSPVFWYAPE 207 Query: 202 VINNKGYDGAKADLWSCGVILFVLM 226 + + A +D+WS GV L+ L+ Sbjct: 208 CLKEYKFYYA-SDVWSFGVTLYELL 231 >5UIU-A nrPDB Length = 323 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 15/210 (7%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIK----VIDKEKVLKNKMIAQIKREISTMKLIKHP 89 G +GEG F V + N VA+K ++D + ++ Q +EI M +H Sbjct: 52 GNKMGEGGFGVV--YKGYVNNTTVAVKKLAAMVD---ITTEELKQQFDQEIKVMAKCQHE 106 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISS---NGRLKEDEARKYFQQLINAVDYCH 146 N++ + + + V ++ G L D++S L K Q N +++ H Sbjct: 107 NLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLH 166 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 HRD+K N+LLD K+SDFGL+ ++ + + GT Y+APE + + Sbjct: 167 ENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL--R 224 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSN 236 G K+D++S GV+L ++ G LP D + Sbjct: 225 GEITPKSDIYSFGVVLLEIITG-LPAVDEH 253 >1S9I-A nrPDB Length = 354 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 103/218 (47%), Gaps = 8/218 (3%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V ++ +G +A K+I E +K + QI RE+ + Sbjct: 11 GELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVL 68 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + R+ E+ K ++ + Sbjct: 69 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 144 YCHSRG-VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + + HRD+KP N+L+++ G +K+ DFG+S Q + D + ++ GT +Y+APE Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLI--DSMANSFVGTRSYMAPER 184 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 + Y ++D+WS G+ L L G P + L Sbjct: 185 LQGTHYS-VQSDIWSMGLSLVELAVGRYPIPPPDAKEL 221 >3RP9-A nrPDB Length = 458 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 73/259 (28%), Positives = 114/259 (44%), Gaps = 44/259 (16%) Query: 3 SRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI 62 R S P+ S P S +YE+ +G G++ V E D + +V+ Sbjct: 29 QRKQHHSSKPTASMPRPHSDWQIP--DRYEIRHLIGTGSYGHV-----CEAYDKLEKRVV 81 Query: 63 DKEKVLK--NKMI--AQIKREISTMKLIKHPNVIRMFEVMASKT-----KIYFVLEFVTG 113 +K+L+ +I +I REI+ + + H +V+++ +++ K ++Y VLE Sbjct: 82 AIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADS 141 Query: 114 GELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSD 172 F K+ + L E + L+ V Y HS G+ HRDLKP N L++ + ++KV D Sbjct: 142 D--FKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCD 199 Query: 173 FGL-----------SALPQQVREDGL-LHTTCGTPN-------------YVAPEVINNKG 207 FGL S LP RED + L T T N Y APE+I + Sbjct: 200 FGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQE 259 Query: 208 YDGAKADLWSCGVILFVLM 226 D+WS G I L+ Sbjct: 260 NYTEAIDVWSIGCIFAELL 278 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 22/36 (61%) Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 P SA A L+KR+L NP RIT E + + +FK+ Sbjct: 367 PASSADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >5KKR-C nrPDB Length = 395 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 102/218 (46%), Gaps = 8/218 (3%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 63 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 120 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 121 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 180 Query: 144 YCHSRG-VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + + HRD+KP N+L+++ G +K+ DFG+S Q + D + ++ GT +Y++PE Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLI--DSMANSFVGTRSYMSPER 236 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 + Y ++D+WS G+ L + G P + L Sbjct: 237 LQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 273 >2PSQ-A nrPDB Length = 370 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 69/282 (24%), Positives = 130/282 (46%), Gaps = 33/282 (11%) Query: 30 KYELGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 K LG+ LGEG F +V A V + VA+K++ + K+ ++ + E+ Sbjct: 82 KLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEM 139 Query: 83 MKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-----------GRLKEDE 130 MK+I KH N+I + +Y ++E+ + G L + + + R+ E++ Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 131 AR-----KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 QL ++Y S+ HRDL N+L+ N +K++DFGL+ + D Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI--D 257 Query: 186 GLLHTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYK 242 TT G ++APE + ++ Y ++D+WS GV+++ + G P+ + L+K Sbjct: 258 YYKKTTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 316 Query: 243 KIFKAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + + P + ++ R P+ R TF +++E+ Sbjct: 317 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >3QD2-B nrPDB Length = 332 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 101/213 (47%), Gaps = 19/213 (8%) Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE---ARKYFQQLINAVDYCH 146 N + + + K +Y ++ L D ++ L++ E F Q+ AV++ H Sbjct: 122 NTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLH 181 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGL-SALPQQVREDGLL--------HT-TCGTPN 196 S+G+ HRDLKP N+ + +KV DFGL +A+ Q E +L HT GT Sbjct: 182 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKL 241 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGY-LPFEDSNLTSLYKKI-FKAEFTCPPW 254 Y++PE I+ Y K D++S G+ILF L+ + E + + + + F FT Sbjct: 242 YMSPEQIHGNNY-SHKVDIFSLGLILFELLYSFSTQMERVRIITDVRNLKFPLLFTQK-- 298 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 +++ +L P+P R ++IEN F+ Sbjct: 299 -YPQEHMMVQDMLSPSPTERPEATDIIENAIFE 330 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 6/67 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ--IKREISTMKLIKH 88 +E + +G G F V A+N + N AIK I L N+ +A+ + RE+ + ++H Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKALAKLEH 63 Query: 89 PNVIRMF 95 P ++R F Sbjct: 64 PGIVRYF 70 >3EQC-A nrPDB Length = 360 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 102/218 (46%), Gaps = 8/218 (3%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 28 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 85 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 86 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 144 YCHSRG-VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + + HRD+KP N+L+++ G +K+ DFG+S Q + D + ++ GT +Y++PE Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG--QLI--DSMANSFVGTRSYMSPER 201 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 + Y ++D+WS G+ L + G P + L Sbjct: 202 LQGTHYS-VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 238 >3E3P-A nrPDB Length = 360 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/258 (25%), Positives = 123/258 (47%), Gaps = 25/258 (9%) Query: 10 STPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK 69 S S + + + R + ++++ R G+GTF V+ + G +VAIK + ++ + Sbjct: 4 SMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFR 63 Query: 70 NKMIAQIKREISTMKLIKHPNVIRM---FEVMASKTK--IYF--VLEFVTGGELFDKISS 122 N+ + QI ++++ ++ HPN++++ F + + + IY V+E+V + + Sbjct: 64 NREL-QIMQDLA---VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCR 117 Query: 123 NGRLKEDEA-----RKYFQQLINAVDYCH--SRGVYHRDLKPENLLL-DANGALKVSDFG 174 N ++ + + QLI ++ H S V HRD+KP N+L+ +A+G LK+ DFG Sbjct: 118 NYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFG 177 Query: 175 LSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED 234 SA E + + + Y APE+I + D+WS G I +M G F Sbjct: 178 -SAKKLSPSEPNVAYIC--SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRG 234 Query: 235 SNLTSLYKKIFKAEFTCP 252 N +I + CP Sbjct: 235 DNSAGQLHEIVRV-LGCP 251 >3QGY-A nrPDB Length = 286 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 + +G G F V + N D VAIK I + + ++ I E M + HP ++++ Sbjct: 33 QEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFI----EEAEVMMKLSHPKLVQL 87 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + V + I V EF+ G L D + + G + + + Y V HR Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 147 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL N L+ N +KVSDFG++ V +D +T GT + +PEV + Y Sbjct: 148 DLAARNCLVGENQVIKVSDFGMTRF---VLDDQYTSST-GTKFPVKWASPEVFSFSRY-S 202 Query: 211 AKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI 244 +K+D+WS GV+++ V G +P+E+ + + + + I Sbjct: 203 SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >4Y93-A nrPDB Length = 446 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 108/204 (52%), Gaps = 15/204 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 + LG G F VK+ + D VAIK+I + + +++ I + K M + H ++++ Sbjct: 194 KELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAK----VMMNLSHEKLVQL 248 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + V + I+ + E++ G L + + R + + + + + A++Y S+ HR Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 308 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL N L++ G +KVSDFG++ + V +D +T G+ + +PEV+ + Sbjct: 309 DLAARNCLVNDQGVVKVSDFGMT---RYVLDDEYTSST-GSKFPVKWASPEVLMYSKF-S 363 Query: 211 AKADLWSCGVILFVLMA-GYLPFE 233 +K+D+W+ GV+++ + + G +P+E Sbjct: 364 SKSDIWAFGVLMWEIYSLGKMPYE 387 >4XI2-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 122/245 (49%), Gaps = 26/245 (10%) Query: 1 MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELG-------RTLGEGTFAKVKFARNVEN 53 + SR S +++ PS + G G +E+ + LG G F VK+ + Sbjct: 156 LISRLKYPVSKQNKNAPSTAGLG----YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQ 211 Query: 54 GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTG 113 D VAIK+I + + +++ I + K M + H +++++ V + I+ + E++ Sbjct: 212 YD-VAIKMIREGSMSEDEFIEEAK----VMMNLSHEKLVQLYGVCTKQRPIFIITEYMAN 266 Query: 114 GELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSD 172 G L + + R + + + + + A++Y S+ HRDL N L++ G +KVSD Sbjct: 267 GCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSD 326 Query: 173 FGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-G 228 FGLS + V +D ++ G+ + PEV+ + +K+D+W+ GV+++ + + G Sbjct: 327 FGLS---RYVLDDEYT-SSVGSKFPVRWSPPEVLMYSKF-SSKSDIWAFGVLMWEIYSLG 381 Query: 229 YLPFE 233 +P+E Sbjct: 382 KMPYE 386 >5X8I-B nrPDB Length = 346 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/245 (28%), Positives = 103/245 (42%), Gaps = 41/245 (16%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKV-KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 G +YE+ TLGEG F KV + + G +VA+K++ ++ + E Sbjct: 5 CQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN----VDRYCEAARSE 60 Query: 80 ISTMKLIK--HPN----VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRL--KEDEA 131 I ++ + PN ++M E I V E + G +D I NG L + D Sbjct: 61 IQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHI 119 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-------------------NGALKVSD 172 RK Q+ +V++ HS + H DLKPEN+L N +KV D Sbjct: 120 RKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVD 179 Query: 173 FGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGY--L 230 FG + +D T T +Y APEVI G+ D+WS G IL G+ Sbjct: 180 FGSATY-----DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVF 233 Query: 231 PFEDS 235 P DS Sbjct: 234 PTHDS 238 >3DKO-A nrPDB Length = 318 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/262 (26%), Positives = 118/262 (45%), Gaps = 26/262 (9%) Query: 35 RTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIKR----EISTMKLIKHP 89 R +G G F +V R + +VA+ + K LK + +R E S M HP Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAI----KTLKVGYTEKQRRDFLCEASIMGQFDHP 104 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHSR 148 NV+ + V+ + V+EF+ G L + +G+ + + + + Y Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVINN 205 G HRDL N+L+++N KVSDFGLS + + E ++TT G + APE I Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPE--AVYTTTGGKIPVRWTAPEAIQY 222 Query: 206 KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKI-----FKAEFTCPPWFSASA 259 + + A +D+WS G++++ +M+ G P+ D + + K I A CP A Sbjct: 223 RKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCP----AGL 277 Query: 260 KKLIKRILDPNPATRITFAEVI 281 +L+ A R F +++ Sbjct: 278 HQLMLDCWQKERAERPKFEQIV 299 >2H34-A nrPDB Length = 309 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 123/258 (47%), Gaps = 17/258 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK----EKVLKNKMIAQIKREIS 81 T+ G Y L R +G G V A + VA+K++ + + V + +M +RE Sbjct: 31 TQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRM----QREAR 86 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 T ++ P+V+ + + ++Y + + G +L + G L A +Q+ +A Sbjct: 87 TAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSA 146 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL--LHTTCGTPNYVA 199 +D H+ G HRD+KPEN+L+ A+ + DFG+++ ++ L L T GT Y+A Sbjct: 147 LDAAHAAGATHRDVKPENILVSADDFAYLVDFGIAS---ATTDEKLTQLGNTVGTLYYMA 203 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA---EFTCPPWFS 256 PE ++ + +AD+++ +L+ + G P++ L+ + I +A T P Sbjct: 204 PERF-SESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIP 262 Query: 257 ASAKKLIKRILDPNPATR 274 + +I R + NP R Sbjct: 263 VAFDAVIARGMAKNPEDR 280 >5EG3-A nrPDB Length = 334 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 129/282 (45%), Gaps = 33/282 (11%) Query: 30 KYELGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 K LG+ LGEG F +V A V + VA+K++ + K+ ++ + E+ Sbjct: 36 KLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD--LSDLVSEMEM 93 Query: 83 MKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-----------GRLKEDE 130 MK+I KH N+I + +Y ++ + + G L + + + R+ E++ Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 131 AR-----KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 QL ++Y S+ HRDL N+L+ N +K++DFGL+ + D Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI--D 211 Query: 186 GLLHTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYK 242 TT G ++APE + ++ Y ++D+WS GV+++ + G P+ + L+K Sbjct: 212 FFKETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 270 Query: 243 KIFKAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + + P + ++ R P+ R TF +++E+ Sbjct: 271 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4K33-A nrPDB Length = 325 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 29/281 (10%) Query: 29 GKYELGRTLGEGTFAKVKFARNVE-NGDNVAIKVIDKEKVLKN----KMIAQIKREISTM 83 + LG+ LGEG F +V A + + D A V K+LK+ K ++ + E+ M Sbjct: 36 ARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM 95 Query: 84 KLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS---------SNGRLKEDEARK 133 K+I KH N+I + +Y ++E+ G L + + S K E + Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 134 YFQQLINA-------VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 F+ L++ ++Y S+ HRDL N+L+ + +K++DFGL+ + D Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL--DY 213 Query: 187 LLHTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKK 243 TT G ++APE + ++ Y ++D+WS GV+L+ + G P+ + L+K Sbjct: 214 YKETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 272 Query: 244 IFKAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + + P +I R P+ R TF +++E+ Sbjct: 273 LKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >3A4O-X nrPDB Length = 286 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 102/207 (49%), Gaps = 16/207 (7%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 +L + LG G F +V + N VA+K + + + E + MK ++H + Sbjct: 16 KLVKRLGAGQFGEV-WMGYYNNSTKVAVKTLKPGTM----SVQAFLEEANLMKTLQHDKL 70 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRG 149 +R++ V+ + IY + E++ G L D + S+ G++ + + Q+ + Y + Sbjct: 71 VRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKN 130 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNK 206 HRDL+ N+L+ + K++DFGL+ +V ED G + APE IN Sbjct: 131 YIHRDLRAANVLVSESLMCKIADFGLA----RVIEDNEYTAREGAKFPIKWTAPEAINF- 185 Query: 207 GYDGAKADLWSCGVILF-VLMAGYLPF 232 G K+D+WS G++L+ ++ G +P+ Sbjct: 186 GCFTIKSDVWSFGILLYEIVTYGKIPY 212 >5B2L-A nrPDB Length = 324 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 75/293 (25%), Positives = 132/293 (45%), Gaps = 40/293 (13%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVI----DKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 +G GT +V R + G +A+K + +KE+ + M + +K P ++ Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDV-----VLKSHDCPYIV 79 Query: 93 RMFEVMASKTKIYFVLEFV-TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR-GV 150 + F + T ++ +E + T E K G + E K ++ A+ Y + GV Sbjct: 80 QCFGTFITNTDVFIAMELMGTSAEKLKK-RMQGPIPERILGKMTVAIVKALYYLKEKHGV 138 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN-----N 205 HRD+KP N+LLD G +K+ DFG+S ++ + + G Y+APE I+ Sbjct: 139 IHRDVKPSNILLDERGQIKLCDFGISG---RLVDSKAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLT-SLYKKIFKAEFTCPPW------FSAS 258 YD +AD+WS G+ L L G P+++ + K+ + E PP FS Sbjct: 196 PDYD-IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEE---PPLLPGHMGFSGD 251 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDD 311 + +K L + R + +++E+ + K ++E +V DV + F D Sbjct: 252 FQSFVKDCLTKDHRKRPKYNKLLEHSFIK------RYETLEV---DVASWFKD 295 >3EB0-A nrPDB Length = 383 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 66/248 (26%), Positives = 110/248 (44%), Gaps = 52/248 (20%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G T KY LG+TLG G+F V ++E+G A+K + ++ KN RE+ Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDI 53 Query: 83 MKLIKHPNVIRMFE-------------------------------------VMASKTK-I 104 MK++ H N+I++ + V S+ K + Sbjct: 54 MKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYL 113 Query: 105 YFVLEFV--TGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL 161 ++E+V T ++ +GR + + Y QL AV + HS G+ HRD+KP+NLL Sbjct: 114 NVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLL 173 Query: 162 LDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGV 220 +++ + LK+ DFG + + + + + C Y APE++ DLWS G Sbjct: 174 VNSKDNTLKLCDFGSAK--KLIPSEPSVAYICSR-FYRAPELMLGATEYTPSIDLWSIGC 230 Query: 221 ILFVLMAG 228 + L+ G Sbjct: 231 VFGELILG 238 >4OLI-A nrPDB Length = 645 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 106/206 (51%), Gaps = 25/206 (12%) Query: 35 RTLGEGTFAKVKF----ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 R LGEG F KV N G+ VA+K + + +++ + K+EI ++ + H + Sbjct: 359 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR--SGWKQEIDILRTLYHEH 416 Query: 91 VIR---MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 +I+ E K+ + V+E+V G L D + + + + + QQ+ + Y HS Sbjct: 417 IIKYKGCCEDQGEKS-LQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHS 474 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQ-----QVREDGLLHTTCGTPNY-VAP 200 + HR+L N+LLD + +K+ DFGL+ A+P+ +VREDG +P + AP Sbjct: 475 QHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG------DSPVFWYAP 528 Query: 201 EVINNKGYDGAKADLWSCGVILFVLM 226 E + + A +D+WS GV L+ L+ Sbjct: 529 ECLKEYKFYYA-SDVWSFGVTLYELL 553 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 94/244 (38%), Gaps = 34/244 (13%) Query: 57 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL 116 V +KV+D + + S M + H ++ + V + V E+V G L Sbjct: 97 VVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 153 Query: 117 FDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYHRDLKPENLLLDANGA------- 167 D R A K QQL +A+ Y ++ + H ++ N+LL G Sbjct: 154 -DVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPF 212 Query: 168 LKVSD--FGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILF- 223 +K+SD GL AL ++ R + + ++APE + + A D W G L Sbjct: 213 IKLSDPGVGLGALSREERVERI--------PWLAPECLPGGANSLSTAMDKWGFGATLLE 264 Query: 224 VLMAGYLPFED---SNLTSLYKKIFK-AEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 + G P + S Y++ + E +CP L + L P R +F Sbjct: 265 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCP-----QLATLTSQCLTYEPTQRPSFRT 319 Query: 280 VIEN 283 ++ + Sbjct: 320 ILRD 323 >3OMV-A nrPDB Length = 307 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 102/207 (49%), Gaps = 8/207 (3%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L +G G+F V + +GD VA+K++ + A + E++ ++ +H N++ Sbjct: 40 LSTRIGSGSFGTV--YKGKWHGD-VAVKILKVVDPTPEQFQA-FRNEVAVLRKTRHVNIL 95 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRGVY 151 +F +K + V ++ G L+ + + + + +Q +DY H++ + Sbjct: 96 -LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNII 154 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD-- 209 HRD+K N+ L +K+ DFGL+ + + + G+ ++APEVI + + Sbjct: 155 HRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPF 214 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSN 236 ++D++S G++L+ LM G LP+ N Sbjct: 215 SFQSDVYSYGIVLYELMTGELPYSHIN 241 >6E4F-A nrPDB Length = 290 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 107/204 (52%), Gaps = 15/204 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 + LG G F VK+ + D VAIK+I + + +++ I + K M + H ++++ Sbjct: 37 KELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAK----VMMNLSHEKLVQL 91 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + V + I+ + E++ G L + + R + + + + + A++Y S+ HR Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 151 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL N L++ G +KVSDFGLS + V +D ++ G+ + PEV+ + Sbjct: 152 DLAARNCLVNDQGVVKVSDFGLS---RYVLDDEYT-SSVGSKFPVRWSPPEVLMYSKF-S 206 Query: 211 AKADLWSCGVILFVLMA-GYLPFE 233 +K+D+W+ GV+++ + + G +P+E Sbjct: 207 SKSDIWAFGVLMWEIYSLGKMPYE 230 >2WO6-A nrPDB Length = 382 Score = 74.7 bits (182), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 82/290 (28%), Positives = 135/290 (46%), Gaps = 43/290 (14%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +YE+ +G+G+F +V A + + VAIK+I +K N+ AQI E+ + Sbjct: 49 GEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQ--AQI--EVRLL 104 Query: 84 KLI-KHPNVIRMFEVMASKTKIY-----FVLEFVTGGELFDKI-SSNGR-LKEDEARKYF 135 +L+ KH ++ + V + ++ V E ++ L+D + ++N R + + RK+ Sbjct: 105 ELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYN-LYDLLRNTNFRGVSLNLTRKFA 163 Query: 136 QQLINAVDYCHS--RGVYHRDLKPENLLL--DANGALKVSDFGLSA-LPQQVREDGLLHT 190 QQ+ A+ + + + H DLKPEN+LL A+K+ DFG S L Q++ + Sbjct: 164 QQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRI------YQ 217 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT 250 + Y +PEV+ YD A D+WS G IL + G F +N KI + Sbjct: 218 YIQSRFYRSPEVLLGMPYDLA-IDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEV-LG 275 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF-------KKGYKAP 293 PP ILD P R F ++ + W K+ YK P Sbjct: 276 IPP----------AHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPP 315 >2HK5-A nrPDB Length = 270 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 100/206 (48%), Gaps = 17/206 (8%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 L + LG G F +V A VA+K + + +A E + MK ++H ++ Sbjct: 19 LEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMSVEAFLA----EANVMKTLQHDKLV 73 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR--KYFQQLINAVDYCHSRGV 150 ++ V+ +K IY + EF+ G L D + S+ K+ + + Q+ + + R Sbjct: 74 KLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 132 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKG 207 HRDL+ N+L+ A+ K++DFGL+ +V ED G + APE IN Sbjct: 133 IHRDLRAANILVSASLVCKIADFGLA----RVIEDNEYTAREGAKFPIKWTAPEAINFGS 188 Query: 208 YDGAKADLWSCGVILF-VLMAGYLPF 232 + K+D+WS G++L ++ G +P+ Sbjct: 189 FT-IKSDVWSFGILLMEIVTYGRIPY 213 >4F0G-A nrPDB Length = 287 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 133/273 (48%), Gaps = 36/273 (13%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIK-VIDKEKVLKNKMI---AQIKREISTMKLIK 87 E + +G+G F V R V++ VAIK +I + + +MI + +RE+ M + Sbjct: 22 EYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLN 81 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCH 146 HPN+++++ +M + ++ V+EFV G+L+ ++ +K + + ++Y Sbjct: 82 HPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQ 139 Query: 147 SRG--VYHRDLKPENLL---LDANGAL--KVSDFGLSALPQQVRE-DGLLHTTCGTPNYV 198 ++ + HRDL+ N+ LD N + KV+DFGLS Q V GLL G ++ Sbjct: 140 NQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLL----GNFQWM 193 Query: 199 APEVI--NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL-YKKIFKAEFT----- 250 APE I + Y KAD +S +IL+ ++ G PF++ + + + + + E Sbjct: 194 APETIGAEEESYT-EKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIP 252 Query: 251 --CPPWFSASAKKLIKRILDPNPATRITFAEVI 281 CPP + +I+ +P R F+ ++ Sbjct: 253 EDCPP----RLRNVIELCWSGDPKKRPHFSYIV 281 >3TT0-A nrPDB Length = 382 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/279 (23%), Positives = 126/279 (45%), Gaps = 33/279 (11%) Query: 33 LGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 LG+ LGEG F +V A + VA+K++ + K+ ++ + E+ MK+ Sbjct: 73 LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEMEMMKM 130 Query: 86 I-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS----------------NGRLKE 128 I KH N+I + +Y ++E+ + G L + + + +L Sbjct: 131 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSS 190 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ + D Sbjct: 191 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI--DYYK 248 Query: 189 HTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF 245 TT G ++APE + ++ Y ++D+WS GV+L+ + G P+ + L+K + Sbjct: 249 KTTNGRLPVKWMAPEALFDRIYT-HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 307 Query: 246 KAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + P + ++ R P+ R TF +++E+ Sbjct: 308 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >5A46-A nrPDB Length = 386 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/279 (23%), Positives = 129/279 (46%), Gaps = 33/279 (11%) Query: 33 LGRTLGEGTFAKVKFARNV---ENGDN----VAIKVIDKEKVLKNKMIAQIKREISTMKL 85 LG+ LGEG F +V A + ++ N VA+K++ + K+ ++ + E+ MK+ Sbjct: 44 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEMEMMKM 101 Query: 86 I-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS----------------NGRLKE 128 I KH N+I + +Y ++E+ + G L + + + +L Sbjct: 102 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS 161 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ + D Sbjct: 162 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI--DYYK 219 Query: 189 HTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF 245 TT G ++APE + ++ Y ++D+WS GV+L+ + G P+ + L+K + Sbjct: 220 KTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 278 Query: 246 KAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + P + ++ R P+ R TF +++E+ Sbjct: 279 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >3GQL-A nrPDB Length = 326 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/279 (23%), Positives = 126/279 (45%), Gaps = 33/279 (11%) Query: 33 LGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 LG+ LGEG F +V A + VA+K++ + K+ ++ + E+ MK+ Sbjct: 32 LGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD--LSDLISEMEMMKM 89 Query: 86 I-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS----------------NGRLKE 128 I KH N+I + +Y ++E+ + G L + + + +L Sbjct: 90 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS 149 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ + D Sbjct: 150 KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI--DYYK 207 Query: 189 HTTCG--TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF 245 TT G ++APE + ++ Y ++D+WS GV+L+ + G P+ + L+K + Sbjct: 208 KTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 266 Query: 246 KAEFTCPPWFSASAKKLIKR-ILDPNPATRITFAEVIEN 283 + P + ++ R P+ R TF +++E+ Sbjct: 267 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >2BUJ-A nrPDB Length = 317 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 99/228 (43%), Gaps = 34/228 (14%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVI------DKEKVLKNKMIAQIKREISTM 83 Y + LGEG F+ V + +G A+K I D+E+ +RE Sbjct: 30 HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEA---------QREADMH 80 Query: 84 KLIKHPNVIRMFEVM----ASKTKIYFVLEFVTGGELFDKI----SSNGRLKEDEARKYF 135 +L HPN++R+ +K + + +L F G L+++I L ED+ Sbjct: 81 RLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLL 140 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFG--------LSALPQQVREDGL 187 + ++ H++G HRDLKP N+LL G + D G + Q + Sbjct: 141 LGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDW 200 Query: 188 LHTTCGTPNYVAPEVINNKGYD--GAKADLWSCGVILFVLMAGYLPFE 233 C T +Y APE+ + + + + D+WS G +L+ +M G P++ Sbjct: 201 AAQRC-TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD 247 >3IO7-A nrPDB Length = 313 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 104/217 (47%), Gaps = 6/217 (2%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVA-IKVIDKEKVLKNKMIA 74 P GS + + + + LG+G F V+ R DN + + K + + + Sbjct: 15 VPRGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR 74 Query: 75 QIKREISTMKLIKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEA 131 +REI +K ++H N+++ V A + + ++E++ G L D + + R+ + Sbjct: 75 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKL 134 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 +Y Q+ ++Y ++ HRDL N+L++ +K+ DFGL+ + Q +E + Sbjct: 135 LQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP 194 Query: 192 CGTPNY-VAPEVINNKGYDGAKADLWSCGVILFVLMA 227 +P + APE + + A +D+WS GV+L+ L Sbjct: 195 GESPIFWYAPESLTESKFSVA-SDVWSFGVVLYELFT 230 >5LPZ-A nrPDB Length = 332 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/260 (27%), Positives = 109/260 (41%), Gaps = 36/260 (13%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G F V + +++G VAIK K + + + E+ T+ IKH N++ + Sbjct: 25 IGSGGFGDV-YKAILKDGSAVAIK---KLIHVSGQGDREFMAEMETIGKIKHRNLVPLLG 80 Query: 97 VMASKTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLINAVDYCH---SRG 149 + V EF+ G L D + + +L RK + + H S Sbjct: 81 YCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE + Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC- 199 Query: 210 GAKADLWSCGVILFVLMAGYLP-----FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 K D++S GV+L L+ G P F D+NL W AK I Sbjct: 200 STKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVG--------------WVKQHAKLRIS 245 Query: 265 RILDP-----NPATRITFAE 279 + DP +PA I + Sbjct: 246 DVFDPELMKEDPALEIELLQ 265 >5UNP-A nrPDB Length = 369 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 86/346 (24%), Positives = 142/346 (41%), Gaps = 83/346 (23%) Query: 30 KYELGRTLGEGTFAKV-KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-- 86 +YE+ TLGEGTF +V + + G VA+K+I + V K K A++ EI+ ++ I Sbjct: 35 RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKII--KNVEKYKEAARL--EINVLEKINE 90 Query: 87 KHPN----VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKE--DEARKYFQQLIN 140 K P+ ++MF+ + E + G FD + N L + R QL Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQ 149 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANG-------------------ALKVSDFGLSALPQQ 181 AV + H + H DLKPEN+L + A++V DFG + + Sbjct: 150 AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHE 209 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN----- 236 T T +Y APEVI G+ D+WS G I+F G+ F+ + Sbjct: 210 HHS-----TIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQTHDNREHL 263 Query: 237 ----------LTSLYKKIFKAEF--------------------TCPP---WFSASAKK-- 261 + + +K K ++ C P + ++ A++ Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHH 323 Query: 262 ----LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD 303 LI+ +L+ PA R+T E +++ +F + P + D S D Sbjct: 324 QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRD 369 >2VWV-A nrPDB Length = 302 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 70/289 (24%), Positives = 121/289 (41%), Gaps = 38/289 (13%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI----STM 83 V ++ +G G F +V R G + I K LK + +RE S M Sbjct: 15 VSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAI---KTLKGGYTERQRREFLSEASIM 71 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAV 142 +HPN+IR+ V+ + + + EF+ G L + N G+ + + + + + Sbjct: 72 GQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 131 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP-NYVA 199 Y HRDL N+L+++N KVSDFGLS ++ D ++ G P + A Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTA 191 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE I + + A +D WS G++++ +M+ F P++ S Sbjct: 192 PEAIAFRKFTSA-SDAWSYGIVMWEVMS---------------------FGERPYWDMSN 229 Query: 260 KKLIKRI-----LDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD 303 + +I I L P P + +++ + W K P+F +LD Sbjct: 230 QDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALD 278 >2PZI-A nrPDB Length = 681 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 121/273 (44%), Gaps = 47/273 (17%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFA--RNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 G G+YE+ + G + A RNV NG V +K + + + +A +R+ Sbjct: 75 GDIVAGQYEVKGCIAHGGLGWIYLALDRNV-NGRPVVLKGLVHSGDAEAQAMAMAERQF- 132 Query: 82 TMKLIKHPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 + + HP+++++F + + Y V+E+V G L K S +L EA Y Sbjct: 133 -LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLL 189 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 +++ A+ Y HS G+ + DLKPEN++L LK+ D G + ++ G L+ GTP Sbjct: 190 EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVS---RINSFGYLY---GTPG 242 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGY----------LPFEDSNLTSLYKKIFK 246 + APE++ D+++ G L L LP ED + Y Sbjct: 243 FQAPEIVRTG--PTVATDIYTVGRTLAALTLDLPTRNGRYVDGLP-EDDPVLKTYD---- 295 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 S +L++R +DP+P R T AE Sbjct: 296 -----------SYGRLLRRAIDPDPRQRFTTAE 317 >6CTH-A nrPDB Length = 309 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 98/197 (49%), Gaps = 11/197 (5%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LGEG F V ++ +A+K + + + I + E+ + ++H N++++ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRAS---KQGIKEYASEVKIISRLRHKNLVKLIG 79 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR-KYFQQLINAVDYCHSRG---VYH 152 + ++ V EF+ G L I L E R + + L +A+ Y H G V H Sbjct: 80 WCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLH 139 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT-TCGTPNYVAPEVINNKGYDGA 211 RD+K N++LD++ K+ DFGL+ L + GL T GT Y+APE +++ G Sbjct: 140 RDIKTSNIMLDSSFNAKLGDFGLARLVDHAK--GLKKTLLAGTVGYMAPECLSS-GKASK 196 Query: 212 KADLWSCGVILFVLMAG 228 ++D++S GV+ + +G Sbjct: 197 ESDVYSFGVVALEIASG 213 >2W1I-A nrPDB Length = 326 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 98/198 (49%), Gaps = 6/198 (3%) Query: 35 RTLGEGTFAKVKFARNVENGDNVA-IKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 + LG+G F V+ R DN + + K + + + +REI +K ++H N+++ Sbjct: 47 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVK 106 Query: 94 MFEVM--ASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHSRGV 150 V A + + ++E++ G L D + + R+ + +Y Q+ ++Y ++ Sbjct: 107 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRY 166 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY-VAPEVINNKGYD 209 HRDL N+L++ +K+ DFGL+ + Q +E + +P + APE + + Sbjct: 167 IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFS 226 Query: 210 GAKADLWSCGVILFVLMA 227 A +D+WS GV+L+ L Sbjct: 227 VA-SDVWSFGVVLYELFT 243 >4Y12-A nrPDB Length = 375 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 121/273 (44%), Gaps = 47/273 (17%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFA--RNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 G G+YE+ + G + A RNV NG V +K + + + +A +R+ Sbjct: 114 GDIVAGQYEVKGCIAHGGLGWIYLALDRNV-NGRPVVLKGLVHSGDAEAQAMAMAERQF- 171 Query: 82 TMKLIKHPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 + + HP+++++F + + Y V+E+V G L K S +L EA Y Sbjct: 172 -LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLL 228 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 +++ A+ Y HS G+ + DLKPEN++L LK+ D G + ++ G L+ GTP Sbjct: 229 EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVS---RINSFGYLY---GTPG 281 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGY----------LPFEDSNLTSLYKKIFK 246 + APE++ D+++ G L L LP +D L + Sbjct: 282 FQAPEIVRTG--PTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTY------ 333 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 S +L++R +DP+P R T AE Sbjct: 334 ----------DSYGRLLRRAIDPDPRQRFTTAE 356 >5LPV-A nrPDB Length = 296 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/260 (27%), Positives = 109/260 (41%), Gaps = 36/260 (13%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G F V + +++G VAIK K + + + E+ T+ IKH N++ + Sbjct: 25 IGSGGFGDV-YKAILKDGSAVAIK---KLIHVSGQGDREFMAEMETIGKIKHRNLVPLLG 80 Query: 97 VMASKTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLINAVDYCH---SRG 149 + V EF+ G L D + + +L RK + + H S Sbjct: 81 YCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE + Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC- 199 Query: 210 GAKADLWSCGVILFVLMAGYLP-----FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 K D++S GV+L L+ G P F D+NL W AK I Sbjct: 200 STKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVG--------------WVKQHAKLRIS 245 Query: 265 RILDP-----NPATRITFAE 279 + DP +PA I + Sbjct: 246 DVFDPELMKEDPALEIELLQ 265 >4HVI-A nrPDB Length = 314 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 122/268 (45%), Gaps = 28/268 (10%) Query: 37 LGEGTFAKVKFARNVENGDN----VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG+G F V+ R GDN VA+K + + + +REI +K + ++ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQR---DFQREIQILKALHSDFIV 74 Query: 93 RMFEVM--ASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRG 149 + V + + V+E++ G L D + + RL Y Q+ ++Y SR Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGY 208 HRDL N+L+++ +K++DFGL+ L ++ ++ +P + APE +++ + Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 209 DGAKADLWSCGVILFVLM----------AGYLPFEDS--NLTSLYKKIFKA----EFTCP 252 ++D+WS GV+L+ L A +L S ++ +L + + P Sbjct: 195 -SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAP 253 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEV 280 P A +L+K P+P R +F+ + Sbjct: 254 PACPAEVHELMKLCWAPSPQDRPSFSAL 281 >2I6L-A nrPDB Length = 320 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 120/299 (40%), Gaps = 53/299 (17%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN-KMIAQIKREISTMKLIKHPNVIR 93 + LG G V A + + VAIK I VL + + + REI ++ + H N+++ Sbjct: 17 KPLGCGGNGLVFSAVDNDCDKRVAIKKI----VLTDPQSVKHALREIKIIRRLDHDNIVK 72 Query: 94 MFEVMASK--------------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 +FE++ +Y V E++ + G L E+ AR + QL+ Sbjct: 73 VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLL 130 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANG-ALKVSDFGLS-ALPQQVREDGLLHTTCGTPNY 197 + Y HS V HRDLKP NL ++ LK+ DFGL+ + G L T Y Sbjct: 131 RGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWY 190 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF---------------------ED-S 235 +P ++ + D+W+ G I ++ G F ED Sbjct: 191 RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ 250 Query: 236 NLTSLYKKIFKAEFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 L S+ + + T P P S A +++IL +P R+T E + + + Sbjct: 251 ELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYM 309 >5WNL-A nrPDB Length = 342 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 129/275 (46%), Gaps = 38/275 (13%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIK------VIDKEKVLKNKMIAQIKREIST 82 G++ +G G F +V R+V +AIK V D+E++ ++ E Sbjct: 20 GEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERM-------ELLEEAKK 72 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 M++ K ++ ++ + + + V+E++ G L +K+ ++ L D + + + Sbjct: 73 MEMAKFRYILPVYGI--CQEPVGLVMEYMETGSL-EKLLASEPLPWDLRFRIVHETAVGM 129 Query: 143 DY--CHSRGVYHRDLKPENLLLDANGALKVSDFGLS-----ALPQQVREDGLLHTTCGTP 195 ++ C S + H +LKP N+LLDA+ +K+SDFGL+ + + DGL GT Sbjct: 130 NFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLF----GTI 185 Query: 196 NYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFEDS-NLTSLYKKIFKAEF--- 249 Y+ PE I K +D K D++S ++++ ++ PF D N+ + K+ K Sbjct: 186 AYLPPERIREKSRLFD-TKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPEL 244 Query: 250 --TCPPWFSASAK--KLIKRILDPNPATRITFAEV 280 C P A A L++R +P R TF E+ Sbjct: 245 PPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4E20-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 109/216 (50%), Gaps = 29/216 (13%) Query: 35 RTLGEGTFAKVKF----ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 R LGEG F KV N G+ VA+K + KE ++ + +REI ++ + H + Sbjct: 14 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KEGC-GPQLRSGWQREIEILRTLYHEH 71 Query: 91 VIR---MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 +++ E K+ + V+E+V G L D + + + + + QQ+ + Y H+ Sbjct: 72 IVKYKGCCEDQGEKS-VQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGMAYLHA 129 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQ-----QVREDGLLHTTCGTPNY-VAP 200 + HR L N+LLD + +K+ DFGL+ A+P+ +VREDG +P + AP Sbjct: 130 QHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG------DSPVFWYAP 183 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN 236 E + + A +D+WS GV L+ L L + DSN Sbjct: 184 ECLKECKFYYA-SDVWSFGVTLYEL----LTYCDSN 214 >4HZS-A nrPDB Length = 341 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 105/221 (47%), Gaps = 18/221 (8%) Query: 37 LGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIK------REISTMKLIKHP 89 LG+G+F V+ + +G V++ V K LK +++Q + RE++ M + H Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAV----KCLKPDVLSQPEAMDDFIREVNAMHSLDHR 75 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR 148 N+IR++ V+ + + V E G L D++ + G +Y Q+ + Y S+ Sbjct: 76 NLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESK 134 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGL-SALPQQVREDGLLHTTCGTP-NYVAPEVINNK 206 HRDL NLLL +K+ DFGL ALPQ + ++ P + APE + + Sbjct: 135 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN-DDHYVMQEHRKVPFAWCAPESLKTR 193 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK 246 + A +D W GV L+ + G P+ N + + KI K Sbjct: 194 TFSHA-SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 233 >1U54-B nrPDB Length = 291 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 105/221 (47%), Gaps = 18/221 (8%) Query: 37 LGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIK------REISTMKLIKHP 89 LG+G+F V+ + +G V++ V K LK +++Q + RE++ M + H Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAV----KCLKPDVLSQPEAMDDFIREVNAMHSLDHR 81 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR 148 N+IR++ V+ + + V E G L D++ + G +Y Q+ + Y S+ Sbjct: 82 NLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESK 140 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGL-SALPQQVREDGLLHTTCGTP-NYVAPEVINNK 206 HRDL NLLL +K+ DFGL ALPQ + ++ P + APE + + Sbjct: 141 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN-DDHYVMQEHRKVPFAWCAPESLKTR 199 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK 246 + A +D W GV L+ + G P+ N + + KI K Sbjct: 200 TFSHA-SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 239 >4O2Z-A nrPDB Length = 377 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 33/212 (15%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIK--------VIDKEKVLKNKMIAQIKREI 80 KY L + LG G + + + G+ V+IK V D ++VL REI Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVL---------REI 95 Query: 81 STMKLIKHPNVIRMFEVMASKTKIY------FVLEFVTGGELFDKISSNGRLKEDEARKY 134 M+ H N++ + ++ + Y +V+ + ++ + S L+E + + Sbjct: 96 DMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYF 155 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA---LPQQVREDGLLHTT 191 Q++ + Y HS V HRDLKP NL+ + + LK+ DFGLS +P D ++ Sbjct: 156 VYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVI--- 212 Query: 192 CGTPNYVAPE-VINNKGYDGAKADLWSCGVIL 222 T Y PE ++ N Y A D+WS G I Sbjct: 213 --TRWYRPPELLLENTNYSTA-VDIWSVGCIF 241 >4P5Q-A nrPDB Length = 361 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 107/236 (45%), Gaps = 37/236 (15%) Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E S M HPN+IR+ V+ + V E++ G L + L++ +A+ QL Sbjct: 84 EASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSL------DSFLRKHDAQFTVIQL 137 Query: 139 I-------NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 + + + Y G HRDL N+L+++N KVSDFGLS + + E +TT Sbjct: 138 VGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA--YTT 195 Query: 192 CG--TP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA 247 G P + +PE I + + A +D+WS G++L+ +M+ G P+ + + + K + + Sbjct: 196 RGGKIPIRWTSPEAIAYRKFTSA-SDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG 254 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD 303 PP +A L + +LD W K PKFE LD Sbjct: 255 YRLPPPMDCPAA--LYQLMLDC---------------WQKDRNNRPKFEQIVSILD 293 >1AD5-A nrPDB Length = 438 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 98/204 (48%), Gaps = 21/204 (10%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 +L + LG G F +V A VA+K + + +A E + MK ++H + Sbjct: 185 KLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMSVEAFLA----EANVMKTLQHDKL 239 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR--KYFQQLINAVDYCHSRG 149 +++ V+ +K IY + EF+ G L D + S+ K+ + + Q+ + + R Sbjct: 240 VKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRN 298 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HRDL+ N+L+ A+ K++DFGL+ + + + APE IN + Sbjct: 299 YIHRDLRAANILVSASLVCKIADFGLARVGAKF-----------PIKWTAPEAINFGSFT 347 Query: 210 GAKADLWSCGVILF-VLMAGYLPF 232 K+D+WS G++L ++ G +P+ Sbjct: 348 -IKSDVWSFGILLMEIVTYGRIPY 370 >1JPA-A nrPDB Length = 312 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 84/180 (46%), Gaps = 7/180 (3%) Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQ 137 E S M HPNVI + V+ T + + EF+ G L + N G+ + + Sbjct: 84 EASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRG 143 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP 195 + + Y HRDL N+L+++N KVSDFGLS + D + G P Sbjct: 144 IAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIP 203 Query: 196 -NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPP 253 + APE I + + A +D+WS G++++ +M+ G P+ D + I + ++ PP Sbjct: 204 IRWTAPEAIQYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPP 261 >2H8H-A nrPDB Length = 535 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/249 (27%), Positives = 110/249 (44%), Gaps = 20/249 (8%) Query: 37 LGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+G F +V NG VAIK + K + + Q E MK ++H +++++ Sbjct: 275 LGQGCFGEVWMG--TWNGTTRVAIKTL-KPGTMSPEAFLQ---EAQVMKKLRHEKLVQLY 328 Query: 96 EVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ S+ IY V E+++ G L D K + L+ + Q+ + + Y HR Sbjct: 329 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL+ N+L+ N KV+DFGL+ L ED G + APE G Sbjct: 388 DLRAANILVGENLVCKVADFGLARL----IEDNEYTARQGAKFPIKWTAPEAA-LYGRFT 442 Query: 211 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILD 268 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 502 Query: 269 PNPATRITF 277 P R TF Sbjct: 503 KEPEERPTF 511 >6FYV-A nrPDB Length = 337 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 117/290 (40%), Gaps = 64/290 (22%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKV-KFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 P G +YE+ TLGEG F KV + + +G +VA+K++ + V + + A+ Sbjct: 2 PHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV--KNVGRYREAAR 59 Query: 76 IKREISTMKLIKHPN---------VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRL 126 S +++++H N ++M E + V E + G +D I N L Sbjct: 60 -----SEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFL 113 Query: 127 --KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD-------------------AN 165 + D R+ Q+ ++++ H + H DLKPEN+L N Sbjct: 114 PFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKN 173 Query: 166 GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVL 225 +KV DFG + +D T T +Y APEVI G+ D+WS G IL Sbjct: 174 TDIKVVDFGSATY-----DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEY 227 Query: 226 MAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 G+ F+ + S +++RIL P P I Sbjct: 228 YLGFTVFQTHD-------------------SKEHLAMMERILGPIPQHMI 258 >3N9X-A nrPDB Length = 432 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 31/223 (13%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKH 88 Y + +G G++ V A + NVAIK +++ E ++ K +I REI+ + +K Sbjct: 28 YIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCK---RILREITILNRLKS 84 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 +IR+++++ ++Y VLE + +L + L E+ + L+ + Sbjct: 85 DYIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL--------------------PQQVR 183 + H G+ HRDLKP N LL+ + ++KV DFGL+ P Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 184 EDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM 226 L + T Y APE+I + D+WS G I L+ Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >4LFI-A nrPDB Length = 374 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 48/150 (32%), Positives = 81/150 (54%), Gaps = 13/150 (8%) Query: 88 HPNVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 H N+I +F+++ SKT V E+V + +I +L + E R Y +L+ A+DY Sbjct: 132 HANIIHLFDIIKDPISKTPA-LVFEYVDNVDF--RILY-PKLTDLEIRFYMFELLKALDY 187 Query: 145 CHSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE-V 202 CHS G+ HRD+KP N+++D N L++ D+GL+ E + + + PE + Sbjct: 188 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME---YNVRVASRFFKGPELL 244 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPF 232 ++ + YD + DLWS G +L ++ PF Sbjct: 245 VDYRMYDYS-LDLWSFGTMLASMIFKREPF 273 >3NIE-A nrPDB Length = 429 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 101/229 (44%), Gaps = 40/229 (17%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKH 88 YE+ +G G++ V A + NVAIK +++ E ++ K +I REI+ + +K Sbjct: 30 YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCK---RILREITILNRLKS 86 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 +IR+ +++ + ++Y VLE + +L + L E + L+ Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH-------------- 189 + H G+ HRDLKP N LL+ + ++K+ DFGL+ + + D +H Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLA---RTINSDKDIHIVNDLEEKEENEEP 202 Query: 190 ------------TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM 226 + T Y APE+I + D+WS G I L+ Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >3KUL-B nrPDB Length = 325 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 119/275 (43%), Gaps = 42/275 (15%) Query: 30 KYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIKR----EISTMK 84 + + + +G G +V + R V +V + + K LK + +R E S M Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAI----KALKAGYTERQRRDFLSEASIMG 105 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN---- 140 HPN+IR+ V+ V E++ G L + L+ + + QL+ Sbjct: 106 QFDHPNIIRLEGVVTRGRLAMIVTEYMENGSL------DTFLRTHDGQFTIMQLVGMLRG 159 Query: 141 ---AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED--GLLHTTCG-- 193 + Y G HRDL N+L+D+N KVSDFGLS +V ED +TT G Sbjct: 160 VGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLS----RVLEDDPDAAYTTTGGK 215 Query: 194 TP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI-----FK 246 P + APE I + + A +D+WS GV+++ VL G P+ + + + Sbjct: 216 IPIRWTAPEAIAFRTFSSA-SDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLP 274 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 A CP + +L+ + A R F++++ Sbjct: 275 APMGCP----HALHQLMLDCWHKDRAQRPRFSQIV 305 >2PL0-A nrPDB Length = 289 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 99/203 (48%), Gaps = 19/203 (9%) Query: 37 LGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG G F +V NG VA+K + + + + +A E + MK ++H ++R++ Sbjct: 31 LGAGQFGEVWMG--YYNGHTKVAVKSLKQGSMSPDAFLA----EANLMKQLQHQRLVRLY 84 Query: 96 EVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ ++ IY + E++ G L D K S +L ++ Q+ + + R HR Sbjct: 85 AVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 143 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL+ N+L+ + K++DFGL+ L ED G + APE I N G Sbjct: 144 DLRAANILVSDTLSCKIADFGLARL----IEDNEYTAREGAKFPIKWTAPEAI-NYGTFT 198 Query: 211 AKADLWSCGVILF-VLMAGYLPF 232 K+D+WS G++L ++ G +P+ Sbjct: 199 IKSDVWSFGILLTEIVTHGRIPY 221 >5MJB-A nrPDB Length = 305 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 96/210 (45%), Gaps = 9/210 (4%) Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQ 137 E S M H N+IR+ V+ + + EF+ L + N G+ + + Sbjct: 77 EASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRG 136 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP 195 + + Y HRDL N+L+++N KVSDFGLS Q D ++ G P Sbjct: 137 IAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIP 196 Query: 196 -NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPP 253 + APE I + + A +D+WS G++++ +M+ G P+ D + + I + ++ PP Sbjct: 197 VRWTAPEAIAYRKFTSA-SDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPP 254 Query: 254 WFSASA--KKLIKRILDPNPATRITFAEVI 281 A +L+ + +R FAE++ Sbjct: 255 PMDCPAALHQLMLDCWQKDRNSRPRFAEIV 284 >6F3F-A nrPDB Length = 455 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 69/249 (27%), Positives = 109/249 (43%), Gaps = 20/249 (8%) Query: 37 LGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+G F +V NG VAIK + K + + Q E MK ++H +++++ Sbjct: 195 LGQGCFGEVWMG--TWNGTTRVAIKTL-KPGTMSPEAFLQ---EAQVMKKLRHEKLVQLY 248 Query: 96 EVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ S+ IY V E++ G L D K + L+ + Q+ + + Y HR Sbjct: 249 AVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR 307 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL+ N+L+ N KV+DFGL+ L ED G + APE G Sbjct: 308 DLRAANILVGENLVCKVADFGLARL----IEDNEYTARQGAKFPIKWTAPEAA-LYGRFT 362 Query: 211 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILD 268 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 363 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 422 Query: 269 PNPATRITF 277 P R TF Sbjct: 423 KEPEERPTF 431 >1FVR-A nrPDB Length = 327 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 71/268 (26%), Positives = 120/268 (44%), Gaps = 29/268 (10%) Query: 36 TLGEGTFAKVKFARNVENG--DNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHPNVI 92 +GEG F +V AR ++G + AIK + KE K+ E+ + KL HPN+I Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDH-RDFAGELEVLCKLGHHPNII 89 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF---------QQLIN--- 140 + + +Y +E+ G L D + + L+ D A QQL++ Sbjct: 90 NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAA 149 Query: 141 ----AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP- 195 +DY + HRDL N+L+ N K++DFGLS + +E + T P Sbjct: 150 DVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS----RGQEVYVKKTMGRLPV 205 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKA-EFTCPP 253 ++A E +N Y +D+WS GV+L+ ++ G P+ LY+K+ + P Sbjct: 206 RWMAIESLNYSVYT-TNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 264 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVI 281 L+++ P R +FA+++ Sbjct: 265 NCDDEVYDLMRQCWREKPYERPSFAQIL 292 >2Y6O-A nrPDB Length = 291 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 9/225 (4%) Query: 35 RTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 + +G G F +V R V + + + + +K E S M HPN+I Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIH 79 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRGVYH 152 + V+ + + E++ G L + N GR + + + + + Y H Sbjct: 80 LEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVH 139 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP-NYVAPEVINNKGYD 209 RDL N+L+++N KVSDFG+S + + E +TT G P + APE I + + Sbjct: 140 RDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAA--YTTRGGKIPIRWTAPEAIAYRKFT 197 Query: 210 GAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPP 253 A +D+WS G++++ +M+ G P+ D + + K I + PP Sbjct: 198 SA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 241 >2QKW-B nrPDB Length = 321 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 116/246 (47%), Gaps = 22/246 (8%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G F KV + + +G VA+K E ++ I + + EI T+ +HP+++ + Sbjct: 47 IGHGVFGKV-YKGVLRDGAKVALKRRTPES---SQGIEEFETEIETLSFCRHPHLVSLIG 102 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL------INAVDYCHSRGV 150 + ++ + +++ G L K G + + Q+L + Y H+R + Sbjct: 103 FCDERNEMILIYKYMENGNL--KRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+K N+LLD N K++DFG+S ++ + L GT Y+ PE KG Sbjct: 161 IHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYF-IKGRLT 219 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK-LIKRILDP 269 K+D++S GV+LF ++ +++ + + + W S +++I+DP Sbjct: 220 EKSDVYSFGVVLFEVLCAR--------SAIVQSLPREMVNLAEWAVESHNNGQLEQIVDP 271 Query: 270 NPATRI 275 N A +I Sbjct: 272 NLADKI 277 >3RAW-A nrPDB Length = 381 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 93/361 (25%), Positives = 139/361 (38%), Gaps = 90/361 (24%) Query: 4 RTTPSRSTPSRSTPSGSSSGGRTRVG-----KYELGRTLGEGTFAKVKFARNVENG-DNV 57 ++ S SRS R+G +YE+ LGEGTF KV + G V Sbjct: 21 QSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQV 80 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K+I V K + A++ EI+ +K IK + F + F EL Sbjct: 81 ALKII--RNVGKYREAARL--EINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELL 136 Query: 118 DKISSNGRLKED--------EARKYFQQLINAVDYCHSRGVYHRDLKPENLLL------- 162 K ++ LKE+ R QL +A+ + H + H DLKPEN+L Sbjct: 137 GK-NTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFET 195 Query: 163 ------------DANGALKVSDFGLSALPQQVREDGLLHTT-CGTPNYVAPEVINNKGYD 209 N +++V+DFG + D HTT T +Y PEVI G+ Sbjct: 196 LYNEHKSCEEKSVKNTSIRVADFGSATF------DHEHHTTIVATRHYRPPEVILELGW- 248 Query: 210 GAKADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIF------------KAEF----- 249 D+WS G ILF G+ F E+ + +KI K ++ Sbjct: 249 AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGG 308 Query: 250 ---------------TCPPWFSASAK---------KLIKRILDPNPATRITFAEVIENEW 285 C P S + L++R+L+ +PA RIT AE + + + Sbjct: 309 LVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPF 368 Query: 286 F 286 F Sbjct: 369 F 369 >3QUP-A nrPDB Length = 323 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/269 (24%), Positives = 122/269 (45%), Gaps = 27/269 (10%) Query: 30 KYELGRTLGEGTFAKVKFAR-NVENGD--NVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 ++ LGR LG+G F V+ A+ E+G VA+K++ K ++ + I + RE + MK Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKML-KADIIASSDIEEFLREAACMKEF 82 Query: 87 KHPNVIRMFEV-MASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 HP+V ++ V + S+ K +L F+ G+L + ++ R+ E+ Q L+ Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLAS-RIGENPFNLPLQTLVR 141 Query: 141 -------AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 ++Y SR HRDL N +L + + V+DFGLS +++ C Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLS---RKIYSGDYYRQGCA 198 Query: 194 TP---NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-E 248 + ++A E + + Y +D+W+ GV ++ +M G P+ +Y + Sbjct: 199 SKLPVKWLALESLADNLYT-VHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNR 257 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRITF 277 PP L+ + +P R +F Sbjct: 258 LKQPPECMEEVYDLMYQCWSADPKQRPSF 286 >5L6P-A nrPDB Length = 298 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 101/232 (43%), Gaps = 8/232 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV-LKNKMIAQIKREISTMKLI 86 V ++ +G G F +V R + G I KV + E S M Sbjct: 18 VSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQF 77 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYC 145 HPN+IR+ V+ + + EF+ L + N G+ + + + + Y Sbjct: 78 DHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP-NYVAPEV 202 HRDL N+L+++N KVSDFGLS + D ++ G P + APE Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA 197 Query: 203 INNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPP 253 I + + A +D+WS G++++ +M+ G P+ D + + + + ++ PP Sbjct: 198 IAYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV-EQDYRLPP 247 >5SYS-A nrPDB Length = 286 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 109/249 (43%), Gaps = 20/249 (8%) Query: 37 LGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+G F + NG VAIK + K + + Q E MK ++H +++++ Sbjct: 26 LGQGCFGECWMG--TWNGTTRVAIKTL-KPGTMSPEAFLQ---EAQVMKKLRHEKLVQLY 79 Query: 96 EVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ S+ IY V E+++ G L D K L+ + Q+ + + Y HR Sbjct: 80 AVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 210 DL+ N+L+ N KV+DFGL+ L ED G + APE G Sbjct: 139 DLRAANILVGENLVCKVADFGLARL----IEDNEYTARQGAKFPIKWTAPEAALY-GRFT 193 Query: 211 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILD 268 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 194 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 253 Query: 269 PNPATRITF 277 +P R TF Sbjct: 254 KDPEERPTF 262 >2R2P-A nrPDB Length = 295 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 112/260 (43%), Gaps = 22/260 (8%) Query: 35 RTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 R +G G F +V R G VAIK + K + E S M HPN+ Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQR--RDFLGEASIMGQFDHPNI 85 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRGV 150 I + V+ + V E++ G L + N G+ + + + + Y G Sbjct: 86 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGY 145 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TP-NYVAPEVINNKG 207 HRDL N+L+++N KVSDFGLS + + E +TT G P + APE I + Sbjct: 146 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA--YTTRGGKIPIRWTAPEAIAFRK 203 Query: 208 YDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI-----FKAEFTCPPWFSASAKK 261 + A +D+WS G++++ V+ G P+ + + K + + CP A+ + Sbjct: 204 FTSA-SDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP----AALYQ 258 Query: 262 LIKRILDPNPATRITFAEVI 281 L+ +R F E++ Sbjct: 259 LMLDCWQKERNSRPKFDEIV 278 >2JD5-A nrPDB Length = 373 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 104/232 (44%), Gaps = 41/232 (17%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN------KMIAQIKREIST 82 +Y L R LG G F+ V A+++ N +VA+K++ +KV K++ ++ +T Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNT 78 Query: 83 ----------MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGE----LFDKISSNGRLKE 128 +KL+ H N ++ V+ F GE L K G + Sbjct: 79 KEDSMGANHILKLLDHFN-------HKGPNGVHVVMVFEVLGENLLALIKKYEHRG-IPL 130 Query: 129 DEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANGA------LKVSDFGLSALPQQ 181 ++ +QL+ +DY H R G+ H D+KPEN+L++ + +K++D G Sbjct: 131 IYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG-----NA 185 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE 233 D + T Y +PEV+ + G AD+WS ++F L+ G FE Sbjct: 186 CWYDEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFE 236 >3LMG-A nrPDB Length = 344 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/272 (24%), Positives = 126/272 (46%), Gaps = 20/272 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL----IKHPN 90 + LG G F V + G+++ I V K V+++K Q + ++ L + H + Sbjct: 37 KVLGSGVFGTVHKGVWIPEGESIKIPVCIK--VIEDKSGRQSFQAVTDHMLAIGSLDHAH 94 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRG 149 ++R+ + + + V +++ G L D + + G L + Q+ + Y G Sbjct: 95 IVRLLG-LCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTP-NYVAPEVINNKG 207 + HR+L N+LL + ++V+DFG++ LP ++ LL++ TP ++A E I+ Sbjct: 154 MVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQ--LLYSEAKTPIKWMALESIHFGK 211 Query: 208 YDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK-- 264 Y ++D+WS GV ++ LM G P+ L + + K E P ++ Sbjct: 212 YT-HQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVK 270 Query: 265 -RILDPNPATRITFAEVIENEWFKKGYKAPKF 295 ++D N R TF E + NE+ + P++ Sbjct: 271 CWMIDEN--IRPTFKE-LANEFTRMARDPPRY 299 >5M07-A nrPDB Length = 276 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 43/275 (15%) Query: 16 TPSGSS---SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM 72 P GS + G T G Y + R LG +V ++ A+KV+ ++ Sbjct: 15 VPRGSHMALASGVTFAG-YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEF 73 Query: 73 IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDE 130 + +RE + HP+++ + + +++ +++V G + ++ L E Sbjct: 74 RRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGE 133 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA----LKVSDFGLSALPQQVREDG 186 + A+DY H RG+ HRD+ P N++L + A + ++DFG+++ Sbjct: 134 VLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS--------- 184 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 246 P+Y APE+ DG +AD ++ + L AG P + S+ L Sbjct: 185 -------QPSYPAPELSAGADVDG-RADQYALALTAIHLFAGAPPVDRSHTGPLQ----- 231 Query: 247 AEFTCPPWFSASAKKL------IKRILDPNPATRI 275 PP SA L + R L PA R Sbjct: 232 -----PPKLSAFRPDLARLDGVLSRALATAPADRF 261 >3PLS-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 62/261 (23%), Positives = 121/261 (46%), Gaps = 22/261 (8%) Query: 35 RTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 R +G+G F V ++ N AIK + ++ + + + RE M+ + HPNV Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSL--SRITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 92 IRMFEVMASKTKI-YFVLEFVTGGELFDKISSNGRLKEDEARKYF-QQLINAVDYCHSRG 149 + + +M + + +L ++ G+L I S R + F Q+ ++Y + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCGTP-NYVAPEVINNKG 207 HRDL N +LD + +KV+DFGL+ + + H P + A E + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 208 YDGAKADLWSCGVILFVLMA-------GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 + K+D+WS GV+L+ L+ PF+ ++ + +++ + E+ CP S Sbjct: 205 F-TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEY-CP----DSLY 258 Query: 261 KLIKRILDPNPATRITFAEVI 281 +++++ + +PA R TF ++ Sbjct: 259 QVMQQCWEADPAVRPTFRVLV 279 >3ALO-A nrPDB Length = 327 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 42/117 (35%), Positives = 66/117 (56%), Gaps = 12/117 (10%) Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT-TCGTPNYVAPEVIN---- 204 + HRD+KP N+LLD +G +K+ DFG+S Q V D + T G Y+APE I+ Sbjct: 147 IIHRDIKPSNILLDRSGNIKLCDFGISG--QLV--DSIAKTRDAGCRPYMAPERIDPSAS 202 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 +GYD ++D+WS G+ L+ L G P+ N S++ ++ + PP S S ++ Sbjct: 203 RQGYD-VRSDVWSLGITLYELATGRFPYPKWN--SVFDQLTQVVKGDPPQLSNSEER 256 >6HMD-A nrPDB Length = 365 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 103/206 (50%), Gaps = 16/206 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L R LG G +++V A N+ N + V +K++ K K K +I + N Sbjct: 55 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT-----N 109 Query: 91 VIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 +I++ + + SKT V E++ + F ++ L + + R Y +L+ A+DYCHS Sbjct: 110 IIKLIDTVKDPVSKTPA-LVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALDYCHS 165 Query: 148 RGVYHRDLKPENLLLDANG-ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 +G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ + Sbjct: 166 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 222 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPF 232 D+WS G +L ++ PF Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPF 248 >5XVU-A nrPDB Length = 332 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 76/148 (51%), Gaps = 11/148 (7%) Query: 89 PNVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 PN+I++ +++ +KT + E++ D + + + + R Y Q++ A+DYC Sbjct: 86 PNIIKLLDIVKDPVTKTPS-LIFEYINN---IDFKTLYPKFTDKDIRYYIYQILKALDYC 141 Query: 146 HSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS+G+ HRD+KP N+++D N +++ +GL+ +E + + Y PE++ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQE---YNVRVASRYYKGPELLI 198 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPF 232 + D+WS G +L ++ PF Sbjct: 199 DLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 >2DQ7-X nrPDB Length = 283 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 111/254 (43%), Gaps = 20/254 (7%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +L + LG G F +V NG+ VAIK + + + E MK +KH Sbjct: 12 QLIKRLGNGQFGEVWMG--TWNGNTKVAIKTLKPGTMSPESFL----EEAQIMKKLKHDK 65 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGR-LKEDEARKYFQQLINAVDYCHSR 148 +++++ V+ S+ IY V E++ G L D + GR LK Q+ + Y Sbjct: 66 LVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 124 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINN 205 HRDL+ N+L+ K++DFGL+ L ED G + APE Sbjct: 125 NYIHRDLRSANILVGNGLICKIADFGLARL----IEDNEYTARQGAKFPIKWTAPEA-AL 179 Query: 206 KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLI 263 G K+D+WS G++L L+ G +P+ N + +++ + CP S +L+ Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 239 Query: 264 KRILDPNPATRITF 277 +P R TF Sbjct: 240 IHCWKKDPEERPTF 253 >3LLT-A nrPDB Length = 360 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 98/229 (42%), Gaps = 41/229 (17%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R +G+GTF +V ++++N A+KV+ K K K E +K I++ ++ Sbjct: 41 RKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIK----KYTRSAKIEADILKKIQNDDINNN 96 Query: 95 FEVMASKTKIYF---VLEF-VTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHSR 148 V +Y+ L F G L++ I+ N ++ + Y +++ A++Y Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKM 156 Query: 149 GVYHRDLKPENLLLD-------------------------ANGALKVSDFGLSALPQQVR 183 + H DLKPEN+LLD + +K+ DFG + Sbjct: 157 SLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYH 216 Query: 184 EDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 + T Y APEVI N G+D +D+WS G +L L G L F Sbjct: 217 G-----SIINTRQYRAPEVILNLGWD-VSSDMWSFGCVLAELYTGSLLF 259 >4PDO-A nrPDB Length = 299 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 102/221 (46%), Gaps = 33/221 (14%) Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E M H N+IR+ V++ + + E++ G L DK L+E + QL Sbjct: 86 EAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGAL-DKF-----LREKDGEFSVLQL 139 Query: 139 IN-------AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--LLH 189 + + Y + HRDL N+L+++N KVSDFGLS +V ED + Sbjct: 140 VGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS----RVLEDDPEATY 195 Query: 190 TTCG--TP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI- 244 TT G P + APE I+ + + A +D+WS G++++ V+ G P+ + + + K I Sbjct: 196 TTSGGKIPIRWTAPEAISYRKFTSA-SDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIN 254 Query: 245 ----FKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 CP ++ +L+ + A R FA+++ Sbjct: 255 DGFRLPTPMDCP----SAIYQLMMQCWQQERARRPKFADIV 291 >3SV0-A nrPDB Length = 483 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 109/225 (48%), Gaps = 32/225 (14%) Query: 27 RVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 RVG K+ LGR +G G+F ++ N++ + VAIK+ + +K K Q+ E ++ Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLEN----VKTKH-PQLLYESKIYRI 58 Query: 86 IKH----PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 ++ PNV R F V + L + +LF+ S LK Q+IN Sbjct: 59 LQGGTGIPNV-RWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKT--VLMLADQMINR 115 Query: 142 VDYCHSRGVYHRDLKPENLLLD----ANGALKVSDFGL------SALPQQV--REDGLLH 189 V++ HS+ HRD+KP+N L+ AN + + DFGL ++ Q + RE+ L Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRAN-QVYIIDFGLAKKYRDTSTHQHIPYRENKNL- 173 Query: 190 TTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 GT Y + V + G + ++ DL S G +L + G LP++ Sbjct: 174 --TGTARYAS--VNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQ 214 >5HLW-A nrPDB Length = 299 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 120/265 (45%), Gaps = 24/265 (9%) Query: 32 ELGRTLGEGTFAKVKFARNVEN-GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +G G F V ++N G + V ++ ++Q E MK HPN Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 82 Query: 91 VIRMFEV-MASKTKIYFVLEFVTGGELFDKI---SSNGRLKEDEARKYFQQLINAVDYCH 146 V+ + + + S+ VL ++ G+L + I + N +K+ + Q+ + Y Sbjct: 83 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD--LIGFGLQVAKGMKYLA 140 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVI 203 S+ HRDL N +LD +KV+DFGL A +E +H G ++A E + Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGL-ARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNL--TSLY----KKIFKAEFTCPPWFS 256 + + K+D+WS GV+L+ LM G P+ D N ++Y +++ + E+ P + Sbjct: 200 QTQKFT-TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLY- 257 Query: 257 ASAKKLIKRILDPNPATRITFAEVI 281 +++ + P R +F+E++ Sbjct: 258 ----EVMLKCWHPKAEMRPSFSELV 278 >5GNK-A nrPDB Length = 297 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 117/257 (45%), Gaps = 17/257 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKE--KVLKNKMIAQIKREISTMKLIKHPNVI 92 + LG G F V + G+ V I V KE + K +I E M + +P+V Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 84 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ----QLINAVDYCHSR 148 R+ + + T + +++ + G L D + + K++ +Y Q+ ++Y R Sbjct: 85 RLLGICLTST-VQLIMQLMPFGCLLDYVREH---KDNIGSQYLLNWCVQIAKGMNYLEDR 140 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-TP-NYVAPEVINNK 206 + HRDL N+L+ +K++DFGL+ L E+ H G P ++A E I ++ Sbjct: 141 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESILHR 198 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIK 264 Y ++D+WS GV ++ LM G P++ + + + K E PP + ++ Sbjct: 199 IYT-HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMV 257 Query: 265 RILDPNPATRITFAEVI 281 + + +R F E+I Sbjct: 258 KCWMIDADSRPKFRELI 274 >2PVN-A nrPDB Length = 352 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 100/207 (48%), Gaps = 18/207 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YE+ R +G G +++V NV N + + + K + L PN Sbjct: 54 YEVVRKVGRGKYSEVFEGINVNNNEKCI-----IKILKPVKKKKIKREIKILQNLCGGPN 108 Query: 91 VIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 ++++ +++ SKT + E+V + F + L + + R Y +L+ A+DYCHS Sbjct: 109 IVKLLDIVRDQHSKTPS-LIFEYVNNTD-FKVLYPT--LTDYDIRYYIYELLKALDYCHS 164 Query: 148 RGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE-VINN 205 +G+ HRD+KP N+++D L++ D+GL+ +E + + + PE +++ Sbjct: 165 QGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKE---YNVRVASRYFKGPELLVDL 221 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPF 232 + YD + D+WS G + ++ PF Sbjct: 222 QDYDYS-LDMWSLGCMFAGMIFRKEPF 247 >4M66-A nrPDB Length = 325 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 107/232 (46%), Gaps = 37/232 (15%) Query: 17 PSGSSSG---GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI 73 P+G+S+ R + K E +G+G F V A + +VA+K+++ +K Sbjct: 8 PTGASAVPLVSREELKKLEF---VGKGGFGVVFRAHHRTWNHDVAVKIVNSKK------- 57 Query: 74 AQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRL----KED 129 I E+ M +++ NV+ + V +FV+G L + NG L + + Sbjct: 58 --ISWEVKAMVNLRNENVLLLLGVTED-----LQWDFVSGQALVTRFMENGSLAGLLQPE 110 Query: 130 EARKY------FQQLINAVDYCHSRG--VYHRDLKPENLLLDANGALKVSDFGLSALP-- 179 R + Q+++ + Y HS + HRDLKP N+LLD K++DFGLS Sbjct: 111 APRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGG 170 Query: 180 --QQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAG 228 + GT Y+ PE++ +KA D++S G++++ ++AG Sbjct: 171 SQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAG 222 >4F9B-A nrPDB Length = 361 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 100/247 (40%), Gaps = 49/247 (19%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-----QIKREISTMKL 85 +++ +GEGTF+ V A ++V +EK+ +I +I E+ + + Sbjct: 23 FKIEDKIGEGTFSSVYLA-------TAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTV 75 Query: 86 IK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 NV+ + + + ++ D ++S L E R+Y L A+ Sbjct: 76 AGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKR 132 Query: 145 CHSRGVYHRDLKPENLLLDANGALK---VSDFGLSA------------LPQQVREDGLLH 189 H G+ HRD+KP N L N LK + DFGL+ + + +++ Sbjct: 133 IHQFGIVHRDVKPSNFLY--NRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQ 190 Query: 190 TTC--------------GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF--E 233 C GTP + APEV+ D+WS GVI L++G PF Sbjct: 191 NKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA 250 Query: 234 DSNLTSL 240 +LT+L Sbjct: 251 SDDLTAL 257 >4MD7-E nrPDB Length = 391 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 98/206 (47%), Gaps = 16/206 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L R LG G +++V A N+ N + V + + K + L PN Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVV-----VKILKPVKKKKIKREIKILENLRGGPN 93 Query: 91 VIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 +I + +++ S+T V E V + F ++ L + + R Y +++ A+DYCHS Sbjct: 94 IITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 149 Query: 148 RGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 G+ HRD+KP N+++D + L++ D+GL+ +E + + + PE++ + Sbjct: 150 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 206 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPF 232 D+WS G +L ++ PF Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPF 232 >3PP0-A nrPDB Length = 338 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 14/207 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI----STMKLIKHPN 90 + LG G F V + +G+NV I V KVL+ + +EI M + P Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPV--AIKVLRENTSPKANKEILDEAYVMAGVGSPY 80 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRG 149 V R+ + + T + V + + G L D + N GRL + + Q+ + Y Sbjct: 81 VSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR 139 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-TP-NYVAPEVINNKG 207 + HRDL N+L+ + +K++DFGL+ L ++ H G P ++A E I + Sbjct: 140 LVHRDLAARNVLVKSPNHVKITDFGLARLLDI--DETEYHADGGKVPIKWMALESILRRR 197 Query: 208 YDGAKADLWSCGVILFVLMA-GYLPFE 233 + ++D+WS GV ++ LM G P++ Sbjct: 198 FT-HQSDVWSYGVTVWELMTFGAKPYD 223 >3LZB-A nrPDB Length = 327 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 117/257 (45%), Gaps = 17/257 (6%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKE--KVLKNKMIAQIKREISTMKLIKHPNVI 92 + LG G F V + G+ V I V KE + K +I E M + +P+V Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 80 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ----QLINAVDYCHSR 148 R+ + + T + + + + G L D + + K++ +Y Q+ ++Y R Sbjct: 81 RLLGICLTST-VQLITQLMPFGCLLDYVREH---KDNIGSQYLLNWCVQIAKGMNYLEDR 136 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-TP-NYVAPEVINNK 206 + HRDL N+L+ +K++DFGL+ L E+ H G P ++A E I ++ Sbjct: 137 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESILHR 194 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIK 264 Y ++D+WS GV ++ LM G P++ + + + K E PP + +++ Sbjct: 195 IYT-HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMR 253 Query: 265 RILDPNPATRITFAEVI 281 + + +R F E+I Sbjct: 254 KCWMIDADSRPKFRELI 270 >6EII-A nrPDB Length = 352 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 98/206 (47%), Gaps = 16/206 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L R LG G +++V A N+ N + V + + K + L PN Sbjct: 62 YQLVRKLGRGKYSEVFEAINITNNEKVV-----VKILKPVKKKKIKREIKILENLRGGPN 116 Query: 91 VIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 +I + +++ S+T V E V + F ++ L + + R Y +++ A+DYCHS Sbjct: 117 IITLADIVKDPVSRTPA-LVFEHVNNTD-FKQLYQT--LTDYDIRFYMYEILKALDYCHS 172 Query: 148 RGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 G+ HRD+KP N+++D + L++ D+GL+ +E + + + PE++ + Sbjct: 173 MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLVDY 229 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPF 232 D+WS G +L ++ PF Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPF 255 >6GQK-A nrPDB Length = 328 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 67/284 (23%), Positives = 120/284 (42%), Gaps = 44/284 (15%) Query: 33 LGRTLGEGTFAKV--KFARNVENGD---NVAIKVI--DKEKVLKNKMIAQIKREISTMKL 85 G+TLG G F KV A+ + D VA+K++ + +++++K L Sbjct: 45 FGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELK---VLSYL 101 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY----------- 134 H N++ + + E+ G+L + + R K DE Y Sbjct: 102 GNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFL----RRKRDEFVPYKVAPEDLYKDF 157 Query: 135 ---------FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 Q+ + + S+ HRDL N+LL K+ DFGL+ + ++ D Sbjct: 158 LTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLA---RDIKND 214 Query: 186 G--LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLY 241 + P ++APE I N Y ++D+WS G+ L+ L + G P+ + S + Sbjct: 215 SNYVDKGNARLPVKWMAPESIFNSVYT-FESDVWSYGIFLWELFSLGSSPYPGMPVDSKF 273 Query: 242 KKIFKAEF--TCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 K+ K F + P + A ++K D +P R TF +++++ Sbjct: 274 YKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >4PL5-B nrPDB Length = 435 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 118/271 (43%), Gaps = 34/271 (12%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG G + + +N D VA+K I E Q+ RE +HPNVIR F Sbjct: 34 VLGHGAEGTIVYKGMFDNRD-VAVKRILPECFSFADREVQLLRESD-----EHPNVIRYF 87 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKED-EARKYFQQLINAVDYCHSRGVYHRD 154 + Y +E + L + + E Q + + + HS + HRD Sbjct: 88 CTEKDRQFQYIAIE-LCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRD 146 Query: 155 LKPENLLL---DANGALK--VSDFGLS---ALPQQ--VREDGLLHTTCGTPNYVAPEVIN 204 LKP N+LL +A+G +K +SDFGL A+ + R G+ GT ++APE+++ Sbjct: 147 LKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVP----GTEGWIAPEMLS 202 Query: 205 NKGYDGA--KADLWSCGVIL-FVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS--- 258 D D++S G + +V+ GY PF S + C F + Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDC---FHSDKHE 259 Query: 259 ---AKKLIKRILDPNPATRITFAEVIENEWF 286 A++LI++++ +P R + V+++ +F Sbjct: 260 DVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4IAN-A nrPDB Length = 358 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 100/214 (46%), Gaps = 21/214 (9%) Query: 30 KYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIK--REISTMKLI 86 +Y + G+G F+ V AR N VA+K+I ++++ + +++ ++++ Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDY 144 + +R+F K + V E ++ E+ K + L R Y QQL A+ Sbjct: 91 DKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKL 150 Query: 145 CHSRGVYHRDLKPENLLL-DANGALKVSDFGLSALPQQVREDGLLHTTCGTPN-----YV 198 + H D+KP+N+L+ ++ LK+ DFG ++ V ++ + TP Y Sbjct: 151 LKRCNILHADIKPDNILVNESKTILKLCDFGSAS---HVADNDI------TPYLVSRFYR 201 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 APE+I K YD D+WS G L+ L G + F Sbjct: 202 APEIIIGKSYDYG-IDMWSVGCTLYELYTGKILF 234 >3C1X-A nrPDB Length = 373 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 64/265 (24%), Positives = 120/265 (45%), Gaps = 24/265 (9%) Query: 32 ELGRTLGEGTFAKVKFARNVEN-GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +G G F V ++N G + V ++ ++Q E MK HPN Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 151 Query: 91 VIRMFEV-MASKTKIYFVLEFVTGGELFDKI---SSNGRLKEDEARKYFQQLINAVDYCH 146 V+ + + + S+ VL ++ G+L + I + N +K+ + Q+ + + Sbjct: 152 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD--LIGFGLQVAKGMKFLA 209 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVI 203 S+ HRDL N +LD +KV+DFGL A +E +H G ++A E + Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGL-ARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNL--TSLY----KKIFKAEFTCPPWFS 256 + + K+D+WS GV+L+ LM G P+ D N ++Y +++ + E+ P + Sbjct: 269 QTQKFT-TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLY- 326 Query: 257 ASAKKLIKRILDPNPATRITFAEVI 281 +++ + P R +F+E++ Sbjct: 327 ----EVMLKCWHPKAEMRPSFSELV 347 >4FL3-A nrPDB Length = 635 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 93/195 (47%), Gaps = 12/195 (6%) Query: 35 RTLGEGTFAKVK--FARNVENGDNVAIKVIDKE---KVLKNKMIAQIKREISTMKLIKHP 89 + LG G F VK + + + VA+K++ E LK++++A E + M+ + +P Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA----EANVMQQLDNP 430 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++RM + +++ + V+E G L + N +K+ + Q+ + Y Sbjct: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGY 208 HRDL N+LL K+SDFGLS + T P + APE IN + Sbjct: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 Query: 209 DGAKADLWSCGVILF 223 +K+D+WS GV+++ Sbjct: 550 S-SKSDVWSFGVLMW 563 >3UIM-A nrPDB Length = 326 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 97/210 (46%), Gaps = 12/210 (5%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG G F KV R + +G VA+K + +E+ ++ Q + E+ + + H N++R+ Sbjct: 38 LGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGEL--QFQTEVEMISMAVHRNLLRLRG 94 Query: 97 VMASKTKIYFVLEFVTGGE----LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG--- 149 + T+ V ++ G L ++ S L + ++ + Y H Sbjct: 95 FCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPK 154 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 + HRD+K N+LLD V DFGL+ L ++ + GT ++APE ++ G Sbjct: 155 IIHRDVKAANILLDEEFEAVVGDFGLAKL-MDYKDTHVTTAVRGTIGHIAPEYLST-GKS 212 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 K D++ GV+L L+ G F+ + L + Sbjct: 213 SEKTDVFGYGVMLLELITGQRAFDLARLAN 242 >5XD6-A nrPDB Length = 305 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 97/213 (45%), Gaps = 22/213 (10%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +GEG++ +V F +++G AIK +D K + +AQ+ S + ++ NV+ + Sbjct: 30 IGEGSYGRV-FYGILKSGKAAAIKKLDSSKQPDQEFLAQV----SMVSRLRQENVVALLG 84 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE---ARKYFQQLINAV------DYCHS 147 E+ G L D + +K + + Q++ AV +Y H Sbjct: 85 YCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHE 144 Query: 148 RG---VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT--CGTPNYVAPEV 202 + V HRD+K N+LL + K++DF LS Q LH+T GT Y APE Sbjct: 145 KANPHVIHRDIKSSNVLLFDDDVAKIADFDLSN--QAPDMAARLHSTRVLGTFGYHAPEY 202 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 G K+D++S GV+L L+ G P + + Sbjct: 203 AMT-GTLSTKSDVYSFGVVLLELLTGRKPVDHT 234 >5AMN-A nrPDB Length = 299 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 68/269 (25%), Positives = 120/269 (44%), Gaps = 28/269 (10%) Query: 33 LGRTLGEGTFAKVKFA-----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LG+TLGEG F KV A + VA+K++ KE +++ + E + +K + Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSEL-RDLLSEFNVLKQVN 84 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------LKEDEARKYFQQ 137 HP+VI+++ + + ++E+ G L + + + L + + Q Sbjct: 85 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQ 144 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-TP- 195 + + Y + HRDL N+L+ +K+SDFGLS ED + + G P Sbjct: 145 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR--DVYEEDSYVKRSQGRIPV 202 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILF--VLMAG--YLPFEDSNLTSLYKKIFKAEFTC 251 ++A E + + Y ++D+WS GV+L+ V + G Y L +L K + E Sbjct: 203 KWMAIESLFDHIYT-TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME--R 259 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEV 280 P S +L+ + P R FA++ Sbjct: 260 PDNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >5U6B-A nrPDB Length = 307 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 118/278 (42%), Gaps = 34/278 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE---KVLKNKMIAQIKREISTMKLI 86 K LG+TLGEG F V + N D+ +KV K + + E MK Sbjct: 24 KVALGKTLGEGEFGAVMEGQ--LNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF 81 Query: 87 KHPNVIRMFEVM------ASKTKIYFVLEFVTGGEL--FDKISSNG----RLKEDEARKY 134 HPNV+R+ V S +L F+ G+L F S G L K+ Sbjct: 82 DHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKF 141 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT--TC 192 + + ++Y ++ HRDL N +L+ N ++ V+DFGLS +++ Sbjct: 142 MADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLS---KKIYNGDYYRQGRIA 198 Query: 193 GTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI-----F 245 P ++A E + ++ Y +K+D+WS GV ++ + G P+ + +Y + Sbjct: 199 KMPVKWIAIESLADRVY-TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 K C A L+ R + NP R +F E+ E+ Sbjct: 258 KQPADCLDGLYA----LMSRCWELNPQDRPSFTELRED 291 >4JRN-A nrPDB Length = 372 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 72/291 (24%), Positives = 118/291 (40%), Gaps = 48/291 (16%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK---LIKH-- 88 G LG G FA V A +VE + +A+KV EK ++ + ++RE S + L K Sbjct: 73 GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 89 ----------PNVIRMFEVMASKTKI-----------YFVLEFVTGGELFDKIS---SNG 124 P+ + M E + T++ YF+L ++ IS + Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDA 192 Query: 125 RLKEDE----ARKYFQ-QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP 179 + + E R Y Q I V ++G+ H D+KP N LL +G L + DFG Sbjct: 193 SVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG----- 247 Query: 180 QQVREDGLLHTTCGTPNYVAPE-VINNKGYDGA-KADLWSCGVILFVLMAGYLPFEDSNL 237 R + + GTP Y PE G D W G+ L+ + P + Sbjct: 248 -TYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---TPA 303 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 ++ + A+ CP + LI+ +L+ +P R+ + +E FK+ Sbjct: 304 DGIWDYLHFAD--CPS-TPELVQDLIRSLLNRDPQKRMLPLQALETAAFKE 351 >5C26-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 93/195 (47%), Gaps = 12/195 (6%) Query: 35 RTLGEGTFAKVK--FARNVENGDNVAIKVIDKEK---VLKNKMIAQIKREISTMKLIKHP 89 + LG G F VK + + + VA+K++ E LK++++A E + M+ + +P Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA----EANVMQQLDNP 88 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++RM + +++ + V+E G L + N +K+ + Q+ + Y Sbjct: 89 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 147 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGY 208 HRDL N+LL K+SDFGLS + T P + APE IN + Sbjct: 148 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 207 Query: 209 DGAKADLWSCGVILF 223 +K+D+WS GV+++ Sbjct: 208 -SSKSDVWSFGVLMW 221 >6J5U-C nrPDB Length = 426 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 115/276 (41%), Gaps = 35/276 (12%) Query: 37 LGEGTFAKV---------KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LGEG F V A +G VA+K + E +K + E++ + + Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHK---EWLTEVNYLGQLS 148 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEA--RKYFQQLINAVDYC 145 HPN++ + A V EF+ G L + + G A K + + Sbjct: 149 HPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFL 208 Query: 146 HS--RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 H V +RD K N+LLDA+ K+SDFGL+ + GT Y APE + Sbjct: 209 HEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYV 268 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLY-------------KKIFKAEFT 250 G AK+D++S GV+L L++G ++SN + Y +K+F+ T Sbjct: 269 AT-GRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRKLFRIMDT 327 Query: 251 -----CPPWFSASAKKLIKRILDPNPATRITFAEVI 281 P + +A L + L+P+ R +EV+ Sbjct: 328 KLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >4XLV-A nrPDB Length = 328 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 65/281 (23%), Positives = 124/281 (44%), Gaps = 44/281 (15%) Query: 30 KYELGRTLGEGTFAKVK--FARNVENGD---NVAIKVIDKEKVLKNKMIAQIKREISTMK 84 K L R LG+G+F V AR++ G+ VA+K +++ L+ ++ + E S MK Sbjct: 40 KITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERI--EFLNEASVMK 97 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--------NGRLKE--DEARKY 134 +V+R+ V++ V+E + G+L + S GR E + Sbjct: 98 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 157 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--------DG 186 ++ + + Y +++ HRDL N ++ + +K+ DFG++ + + E G Sbjct: 158 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT---RDIYETDYYRKGGKG 214 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIF 245 LL ++APE + + G +D+WS GV+L+ + + P++ + + K + Sbjct: 215 LLPV-----RWMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 268 Query: 246 KAEF-----TCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + CP L++ NP R TF E++ Sbjct: 269 DGGYLDQPDNCP----ERVTDLMRMCWQFNPNMRPTFLEIV 305 >3V5Q-A nrPDB Length = 297 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 98/225 (43%), Gaps = 23/225 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA---QIKREISTMKLIKHP 89 L R LGEG F KV F N K++ K LK+ +A +RE + ++H Sbjct: 19 LKRELGEGAFGKV-FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHE 77 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG----------------RLKEDEARK 133 ++++ + V + V E++ G+L + ++G L + Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 Q+ + + Y S+ HRDL N L+ AN +K+ DFG+S + T Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLP-FEDSN 236 ++ PE I + + ++D+WS GVIL+ + G P F+ SN Sbjct: 198 PIRWMPPESIMYRKFT-TESDVWSFGVILWEIFTYGKQPWFQLSN 241 >5TOS-A nrPDB Length = 395 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 91/180 (50%), Gaps = 14/180 (7%) Query: 57 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL 116 +A+K +++E ++ + EI+ + + HPN++++ V EF+ G L Sbjct: 102 IAVKKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSL 158 Query: 117 FDKISSNGRLKEDEARKYFQQLINAVD------YCHSRGV--YHRDLKPENLLLDANGAL 168 + + G + +F ++ A+D + HS V +RD+K N+LLDA+ Sbjct: 159 ENHLFRRGAYFK--PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 228 K+SDFGL+ + GT Y APE +++ G+ A++D++S GV+L +++G Sbjct: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSG 275 >4CRL-A nrPDB Length = 406 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 19/166 (11%) Query: 78 REISTMKLIKHPNVIRMFEVMASKT--KIYFVLEFVTGGEL----FDKISSNGR----LK 127 REI+ ++ +KHPNVI + +V S K++ + ++ F + S + L Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLP 127 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL----DANGALKVSDFGLSAL---PQ 180 + Q+++ + Y H+ V HRDLKP N+L+ G +K++D G + L P Sbjct: 128 RGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPL 187 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM 226 + D L T Y APE++ + D+W+ G I L+ Sbjct: 188 KPLAD--LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELL 231 >5WNO-A nrPDB Length = 330 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 132/290 (45%), Gaps = 24/290 (8%) Query: 32 ELGRTLGEGTFAKV-------KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 +L + LG G F V K A+NV+ VAIKV ++ ++M+ E + M Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIP--VAIKVFQTDQSQTDEML----EEATNMF 78 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL--FDKISSNGRLKEDEARKYFQQLINAV 142 ++H N++++ + V + G L F K+ L E Y Q+ + + Sbjct: 79 RLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKEN-LGAREQVLYCYQIASGM 137 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + V HRDL N+L+ ++++DFGLS + + + + + ++A E+ Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI 197 Query: 203 INNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAK 260 + Y A +D+W+ GV + ++ G P++ + S++ + + PP S Sbjct: 198 FSKHCYTHA-SDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLY 256 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENAD-VSLDDVDA 307 + + R +P +R F I E FK+ K P+ EN++ +S D+ A Sbjct: 257 QELLRCWMADPKSRPGFE--ILYERFKEFCKVPQLFLENSNKISESDLSA 304 >5U6C-A nrPDB Length = 315 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 97/208 (46%), Gaps = 22/208 (10%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN---KMIAQIKREISTMKLIKHP 89 LG+ LGEG F V N++ D ++KV K L N + I + E + MK HP Sbjct: 40 LGKILGEGEFGSV-MEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 90 NVIRMFEV---MASK--TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN---- 140 NV+R+ V M+S+ K +L F+ G+L + + RL+ Q L+ Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS-RLETGPKHIPLQTLLKFMVD 157 Query: 141 ---AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS--ALPQQVREDGLLHTTCGTP 195 ++Y +R HRDL N +L + + V+DFGLS G + Sbjct: 158 IALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM--PV 215 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILF 223 ++A E + ++ Y +K+D+W+ GV ++ Sbjct: 216 KWIAIESLADRVYT-SKSDVWAFGVTMW 242 >1U59-A nrPDB Length = 287 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 101/228 (44%), Gaps = 20/228 (8%) Query: 37 LGEGTFAKVK--FARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG G F V+ R + +VAIKV+ + EK +M+ RE M + +P ++ Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM----REAQIMHQLDNPYIV 73 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFD-KISSNGRLKEDEARKYFQQLINAVDYCHSRGVY 151 R+ V ++ + V+E GG L + + + Q+ + Y + Sbjct: 74 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP----NYVAPEVINNKG 207 HRDL N+LL K+SDFGLS + + D +T + APE IN + Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLS---KALGADDSYYTARSAGKWPLKWYAPECINFRK 189 Query: 208 YDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPP 253 + +++D+WS GV ++ L G P++ + I + + CPP Sbjct: 190 F-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 236 >2RIO-A nrPDB Length = 434 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 103/233 (44%), Gaps = 35/233 (15%) Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS------NGRL-KEDEARKYFQQLIN 140 HPNVIR + + +Y LE + L D + S N +L KE +Q+ + Sbjct: 68 HPNVIRYYCSETTDRFLYIALE-LCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 141 AVDYCHSRGVYHRDLKPENLLLDA-------------NGALKVSDFGLSALPQ--QVRED 185 V + HS + HRDLKP+N+L+ N + +SDFGL Q Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAK------ADLWSCGVILFVLMA-GYLPFED--SN 236 L+ GT + APE++ K D++S G + + +++ G PF D S Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSR 246 Query: 237 LTSLYKKIFKA-EFTCPPWFS--ASAKKLIKRILDPNPATRITFAEVIENEWF 286 +++ + IF E C S A A LI +++D +P R T +V+ + F Sbjct: 247 ESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >1LUF-A nrPDB Length = 343 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 99/234 (42%), Gaps = 39/234 (16%) Query: 32 ELGRTLGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 E R +GEG F +V AR E VA+K++ +E M A +RE + M Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA--SADMQADFQREAALMAEF 107 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFD----------------------KISSNG 124 +PN++++ V A + + E++ G+L + ++SS G Sbjct: 108 DNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPG 167 Query: 125 R--LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS---ALP 179 L E +Q+ + Y R HRDL N L+ N +K++DFGLS Sbjct: 168 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 227 Query: 180 QQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPF 232 + DG ++ PE I Y ++D+W+ GV+L+ + G P+ Sbjct: 228 DYYKADG---NDAIPIRWMPPESIFYNRYT-TESDVWAYGVVLWEIFSYGLQPY 277 >2QLU-A nrPDB Length = 314 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 103/227 (45%), Gaps = 30/227 (13%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S G G +L G F V A+ + D VA+K+ L++K Q +REI Sbjct: 8 SSGLVPRGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIFP----LQDKQSWQSEREIF 61 Query: 82 TMKLIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSN-------GRLKE 128 + +KH N+++ + A K +++ + F G L D + N + E Sbjct: 62 STPGMKHENLLQF--IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAE 119 Query: 129 DEARKYFQQLINAVDYC----HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 +R L V +C H + HRD K +N+LL ++ ++DFGL+ + + Sbjct: 120 TMSRG-LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP 178 Query: 185 DGLLHTTCGTPNYVAPEV----INNKGYDGAKADLWSCGVILFVLMA 227 G H GT Y+APEV IN + + D+++ G++L+ L++ Sbjct: 179 PGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >2OZO-A nrPDB Length = 613 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 20/228 (8%) Query: 37 LGEGTFAKVK--FARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG G F V+ R + +VAIKV+ + EK +M+ RE M + +P ++ Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM----REAQIMHQLDNPYIV 399 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFD-KISSNGRLKEDEARKYFQQLINAVDYCHSRGVY 151 R+ V ++ + V+E GG L + + + Q+ + Y + Sbjct: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT---P-NYVAPEVINNKG 207 HR+L N+LL K+SDFGLS + + D +T P + APE IN + Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLS---KALGADDSYYTARSAGKWPLKWYAPECINFRK 515 Query: 208 YDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPP 253 + +++D+WS GV ++ L G P++ + I + + CPP Sbjct: 516 F-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 >3BEA-A nrPDB Length = 333 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 61/275 (22%), Positives = 119/275 (43%), Gaps = 32/275 (11%) Query: 32 ELGRTLGEGTFAKVKFARNVENG-DNVAIKVIDKEKVLKNKMIAQIKREI-STMKLI--- 86 + G+TLG G F KV A G ++ +KV K+LK+ A K + S +K++ Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKV--AVKMLKSTAHADEKEALMSELKIMSHL 106 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR------------- 132 +H N++ + + + E+ G+L + + R+ E + Sbjct: 107 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDL 166 Query: 133 -KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--LLH 189 + Q+ + + S+ HRD+ N+LL K+ DFGL+ + + D ++ Sbjct: 167 LHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA---RDIMNDSNYIVK 223 Query: 190 TTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFK- 246 P ++APE I + Y ++D+WS G++L+ + G P+ + S + K+ K Sbjct: 224 GNARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD 282 Query: 247 -AEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 + P + + +++ P R TF ++ Sbjct: 283 GYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >2OGV-A nrPDB Length = 317 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/271 (22%), Positives = 121/271 (44%), Gaps = 28/271 (10%) Query: 32 ELGRTLGEGTFAKVKFARNVENG-DNVAIKVIDKEKVLKNKMIAQIKREI-STMKLI--- 86 + G+TLG G F KV A G ++ +KV K+LK+ A K + S +K++ Sbjct: 41 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKV--AVKMLKSTAHADEKEALMSELKIMSHL 98 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGEL--FDKISSNGRLKEDEAR--------KYF 135 +H N++ + + + E+ G+L F + + L +++ R + Sbjct: 99 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFS 158 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--LLHTTCG 193 Q+ + + S+ HRD+ N+LL K+ DFGL+ + + D ++ Sbjct: 159 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA---RDIMNDSNYIVKGNAR 215 Query: 194 TP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFK--AEF 249 P ++APE I + Y ++D+WS G++L+ + G P+ + S + K+ K + Sbjct: 216 LPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 274 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEV 280 P + + +++ P R TF ++ Sbjct: 275 AQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >3MDY-A nrPDB Length = 337 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 28/219 (12%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR-EISTM 83 RT + ++ + +G+G + +V + G+ VA+KV + + + EI Sbjct: 33 RTIAKQIQMVKQIGKGRYGEVWMGK--WRGEKVAVKVF-----FTTEEASWFRETEIYQT 85 Query: 84 KLIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 L++H N++ S T++Y + ++ G L+D + S L K + Sbjct: 86 VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-LDAKSMLKLAYSSV 144 Query: 140 NAVDYCHSR--------GVYHRDLKPENLLLDANGALKVSDFGLSA--LPQQVREDGLLH 189 + + + H+ + HRDLK +N+L+ NG ++D GL+ + D + Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 190 TTCGTPNYVAPEVIN-----NKGYDGAKADLWSCGVILF 223 T GT Y+ PEV++ N AD++S G+IL+ Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILW 243 >1PY5-A nrPDB Length = 326 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 39/236 (16%) Query: 16 TPSGSSSG-----GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 T SGS SG RT L ++G+G F +V R G+ VA+K+ + Sbjct: 11 TTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEV--WRGKWRGEEVAVKIFSSREERSW 68 Query: 71 KMIAQIKREISTMKLIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFD-----KIS 121 A+I + + +++H N++ + T+++ V ++ G LFD ++ Sbjct: 69 FREAEIYQTV----MLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 124 Query: 122 SNG--RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP 179 G +L A + V + HRDLK +N+L+ NG ++D GL+ Sbjct: 125 VEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA--- 181 Query: 180 QQVREDGLLHTT-------CGTPNYVAPEV----INNKGYDGAK-ADLWSCGVILF 223 VR D T GT Y+APEV IN K ++ K AD+++ G++ + Sbjct: 182 --VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFW 235 >3I81-A nrPDB Length = 315 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 129/297 (43%), Gaps = 46/297 (15%) Query: 30 KYELGRTLGEGTFAKVK--FARNV---ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 K + R LG+G+F V A+ V E VAIK +++ ++ ++ + E S MK Sbjct: 19 KITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERI--EFLNEASVMK 76 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-------NGRLKEDEARKYFQ- 136 +V+R+ V++ ++E +T G+L + S N L K Q Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM 136 Query: 137 --QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--------DG 186 ++ + + Y ++ HRDL N ++ + +K+ DFG++ + + E G Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMT---RDIYETDYYRKGGKG 193 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF 245 LL +++PE + + G +D+WS GV+L+ + P++ + + + + Sbjct: 194 LLPV-----RWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVM 247 Query: 246 KAEF-----TCPPWFSASAKKLIKRILDPNPATRITFAEVIEN--EWFKKGYKAPKF 295 + CP +L++ NP R +F E+I + E + G++ F Sbjct: 248 EGGLLDKPDNCPDMLF----ELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 300 >4AT3-A nrPDB Length = 299 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 90/210 (42%), Gaps = 24/210 (11%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN---KMIAQIKREISTMKLIKHP 89 L R LGEG F KV F N K++ K LK+ RE + ++H Sbjct: 17 LKRELGEGAFGKV-FLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHE 75 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-------------RLKEDEARKYFQ 136 ++++ + V + V E++ G+L + ++G L + + Q Sbjct: 76 HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 135 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCG 193 Q+ + Y S+ HRDL N L+ N +K+ DFG+S R G HT Sbjct: 136 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG--HTMLP 193 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILF 223 ++ PE I + + ++D+WS GV+L+ Sbjct: 194 I-RWMPPESIMYRKFT-TESDVWSLGVVLW 221 >3BBT-B nrPDB Length = 328 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 88/195 (45%), Gaps = 5/195 (2%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 92 + LG G F V V G+ V I V K + K + E M + HP+++ Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLV 80 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSRGVY 151 R+ V S T I V + + G L + + + + + Q+ + Y R + Sbjct: 81 RLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 139 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 HRDL N+L+ + +K++DFGL+ L + ++ ++A E I+ + + Sbjct: 140 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF-TH 198 Query: 212 KADLWSCGVILFVLM 226 ++D+WS GV ++ LM Sbjct: 199 QSDVWSYGVTIWELM 213 >3SOC-A nrPDB Length = 322 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 21/186 (11%) Query: 57 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKI----YFVLEFVT 112 VA+K+ +++K Q + E+ ++ +KH N+++ T + + + F Sbjct: 50 VAVKIFP----IQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHE 105 Query: 113 GGELFDKISSN-------GRLKEDEAR--KYFQQLINAVDYCHSRGVYHRDLKPENLLLD 163 G L D + +N + E AR Y + I + H + HRD+K +N+LL Sbjct: 106 KGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLK 165 Query: 164 ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV----INNKGYDGAKADLWSCG 219 N ++DFGL+ + + G H GT Y+APEV IN + + D+++ G Sbjct: 166 NNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMG 225 Query: 220 VILFVL 225 ++L+ L Sbjct: 226 LVLWEL 231 >4XUF-A nrPDB Length = 297 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 108/252 (42%), Gaps = 39/252 (15%) Query: 32 ELGRTLGEGTFAKVKFARNV---ENGDNVAIKV-IDKEKVLKNKMIAQIKREISTMKLIK 87 E G+ LG G F KV A + G ++ + V + KEK ++ A + +L Sbjct: 12 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS 71 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--------------NGRLKEDEARK 133 H N++ + IY + E+ G+L + + S RL+E+E Sbjct: 72 HENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLN 131 Query: 134 ---------YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 + Q+ +++ + HRDL N+L+ +K+ DFGL+ + + Sbjct: 132 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA---RDIMS 188 Query: 185 DG--LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE----DSN 236 D ++ P ++APE + +G K+D+WS G++L+ + G P+ D+N Sbjct: 189 DSNYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 247 Query: 237 LTSLYKKIFKAE 248 L + FK + Sbjct: 248 FYKLIQNGFKMD 259 >3HNG-A nrPDB Length = 360 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 16/158 (10%) Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVREDGLLH 189 Y Q+ +++ SR HRDL N+LL N +K+ DFGL+ P VR+ Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKG---- 259 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE----DSNLTSLYKKI 244 T ++APE I +K Y K+D+WS GV+L+ + G P+ D + S ++ Sbjct: 260 DTRLPLKWMAPESIFDKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREG 318 Query: 245 FKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 + P + + +++ +P R FAE++E Sbjct: 319 MR--MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 >5X02-A nrPDB Length = 347 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 108/252 (42%), Gaps = 39/252 (15%) Query: 32 ELGRTLGEGTFAKVKFARNV---ENGDNVAIKV-IDKEKVLKNKMIAQIKREISTMKLIK 87 E G+ LG G F KV A + G ++ + V + KEK ++ A + +L Sbjct: 51 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS 110 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--------------NGRLKEDEARK 133 H N++ + IY + E+ G+L + + S RL+E+E Sbjct: 111 HENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLN 170 Query: 134 ---------YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 + Q+ +++ + HRDL N+L+ +K+ DFGL+ + + Sbjct: 171 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA---RDIMS 227 Query: 185 DG--LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE----DSN 236 D ++ P ++APE + +G K+D+WS G++L+ + G P+ D+N Sbjct: 228 DSNYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 286 Query: 237 LTSLYKKIFKAE 248 L + FK + Sbjct: 287 FYKLIQNGFKMD 298 >3PG1-A nrPDB Length = 362 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 71/313 (22%), Positives = 122/313 (38%), Gaps = 65/313 (20%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE-------KVLKNKMIA-QIKREIST 82 Y + R + G++ V + E G VAIK + +L + + ++ REI Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 83 MKLIKHPNVIRMFEVMA-----SKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ- 136 + HPN++ + ++ + K+Y V E + +L I + + +YF Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMY 141 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 ++ + H GV HRDL P N+LL N + + DF L+ RED + Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLA------REDT---ADANKTH 192 Query: 197 YV------APE-VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK--- 246 YV APE V+ KG+ D+WS G ++ + F S + KI + Sbjct: 193 YVTHRWYRAPELVMQFKGFTKL-VDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVG 251 Query: 247 -------AEFTCP----------------------PWFSASAKKLIKRILDPNPATRITF 277 F+ P P A LI ++L+ NP RI+ Sbjct: 252 TPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIST 311 Query: 278 AEVIENEWFKKGY 290 + + + +F+ + Sbjct: 312 EQALRHPYFESLF 324 >6HV0-A nrPDB Length = 416 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 85/329 (25%), Positives = 143/329 (43%), Gaps = 35/329 (10%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG G + + +N D VA+K I E Q+ RE +HPNVIR F Sbjct: 15 VLGHGAEGTIVYRGMFDNRD-VAVKRILPECFSFADREVQLLRESD-----EHPNVIRYF 68 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKED-EARKYFQQLINAVDYCHSRGVYHRD 154 + Y +E + L + + E QQ + + + HS + HRD Sbjct: 69 CTEKDRQFQYIAIE-LCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRD 127 Query: 155 LKPENLLL---DANGALK--VSDFGLS---ALPQQ--VREDGLLHTTCGTPNYVAPEVIN 204 LKP N+L+ +A+G +K +SDFGL A+ + R G+ GT ++APE+++ Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVP----GTEGWIAPEMLS 183 Query: 205 NKGYDGA--KADLWSCGVIL-FVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPWF-SAS 258 + D++S G + +V+ G PF S + C P Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVI 243 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNL 318 A++LI++++ +P R + V+++ +F K +F DVS D I +S + Sbjct: 244 ARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQ-DVS----DRIEKESLDGP-- 296 Query: 319 VVERREEGLKTPVTMNAFELISTSQGLNL 347 +V++ E G + V M+ E I+ +L Sbjct: 297 IVKQLERGGRAVVKMDWRENITVPLQTDL 325 >4R7H-A nrPDB Length = 343 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/284 (23%), Positives = 121/284 (42%), Gaps = 41/284 (14%) Query: 32 ELGRTLGEGTFAKVKFARNVENG-DNVAIKVIDKEKVLKNKMIAQIKREI-STMKLI--- 86 + G+TLG G F KV A G ++ +KV K+LK+ A K + S +K++ Sbjct: 53 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKV--AVKMLKSTAHADEKEALMSELKIMSHL 110 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI----------------SSNGRLKED 129 +H N++ + + + E+ T G+L + + G KED Sbjct: 111 GQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKED 170 Query: 130 ----EARKYFQ---QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 E R Q+ + + S+ HRD+ N+LL K+ DFGL+ + + Sbjct: 171 GRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA---RDI 227 Query: 183 REDG--LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLT 238 D ++ P ++APE I + Y ++D+WS G++L+ + G P+ + Sbjct: 228 MNDSNYIVKGNARLPVKWMAPESIFDSVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVN 286 Query: 239 SLYKKIFK--AEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 S + K+ K + P + + +++ P R TF ++ Sbjct: 287 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >3G0E-A nrPDB Length = 336 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 115/287 (40%), Gaps = 44/287 (15%) Query: 30 KYELGRTLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + G+TLG G F KV A + VA+K++ L + + E+ + Sbjct: 47 RLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTER--EALMSELKVLS 104 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE------------- 130 + H N++ + + E+ G+L + + R K D Sbjct: 105 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL----RRKRDSFICSKTSPAIMED 160 Query: 131 ---------ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQ 181 + Q+ + + S+ HRDL N+LL K+ DFGL+ + Sbjct: 161 DELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA---RD 217 Query: 182 VREDG--LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNL 237 ++ D ++ P ++APE I N Y ++D+WS G+ L+ L + G P+ + Sbjct: 218 IKNDSNYVVKGNARLPVKWMAPESIFNCVYT-FESDVWSYGIFLWELFSLGSSPYPGMPV 276 Query: 238 TSLYKKIFKAEF--TCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 S + K+ K F P A ++K D +P R TF ++++ Sbjct: 277 DSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >4LRM-A nrPDB Length = 334 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/260 (24%), Positives = 116/260 (44%), Gaps = 20/260 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKE--KVLKNKMIAQIKREISTMKLIKHP--- 89 + LG G F V + G+ V I V KE + K +I E M + +P Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNP 84 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ----QLINAVDYC 145 +V R+ + + T + + + + G L D + + K++ +Y Q+ ++Y Sbjct: 85 HVCRLLGICLTST-VQLITQLMPFGCLLDYVREH---KDNIGSQYLLNWCVQIAKGMNYL 140 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-TP-NYVAPEVI 203 R + HRDL N+L+ +K++DFGL+ L E+ H G P ++A E I Sbjct: 141 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESI 198 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKK 261 ++ Y ++D+WS GV ++ LM G P++ + + + K E PP + Sbjct: 199 LHRIYT-HQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 257 Query: 262 LIKRILDPNPATRITFAEVI 281 ++ + + +R F E+I Sbjct: 258 IMVKCWMIDADSRPKFRELI 277 >5FM2-A nrPDB Length = 355 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 121/283 (42%), Gaps = 42/283 (14%) Query: 33 LGRTLGEGTFAKVKFA-----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LG+TLGEG F KV A + VA+K++ KE +++ + E + +K + Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSEL-RDLLSEFNVLKQVN 125 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------------LKEDEA 131 HP+VI+++ + + ++E+ G L + + + L + Sbjct: 126 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 185 Query: 132 R--------KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVR 183 R + Q+ + Y + HRDL N+L+ +K+SDFGLS Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR--DVYE 243 Query: 184 EDGLLHTTCG-TP-NYVAPEVINNKGYDGAKADLWSCGVILF--VLMAG--YLPFEDSNL 237 ED + + G P ++A E + + Y ++D+WS GV+L+ V + G Y L Sbjct: 244 EDSYVKRSQGRIPVKWMAIESLFDHIYT-TQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 302 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 +L K + E P S +L+ + P R FA++ Sbjct: 303 FNLLKTGHRME--RPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >3Q4U-A nrPDB Length = 301 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/299 (23%), Positives = 127/299 (42%), Gaps = 54/299 (18%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI---DKEKVLKNKMIAQIKR 78 S RT L +G+G + +V R G+NVA+K+ D++ + + Sbjct: 1 SMQRTVARDITLLECVGKGRYGEV--WRGSWQGENVAVKIFSSRDEKSWFR-------ET 51 Query: 79 EISTMKLIKHPNVIRMFEV-MASK---TKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 E+ +++H N++ M S+ T+++ + + G L+D + L + Sbjct: 52 ELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTT-LDTVSCLRI 110 Query: 135 FQQLINAVDYCHSR--------GVYHRDLKPENLLLDANGALKVSDFGLSALPQQV--RE 184 + + + + H + HRDLK +N+L+ NG ++D GL+ + Q + Sbjct: 111 VLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL 170 Query: 185 DGLLHTTCGTPNYVAPEVINN----KGYDGAK-ADLWSCGVILFVLMAGYL--------- 230 D + GT Y+APEV++ +D K D+W+ G++L+ + + Sbjct: 171 DVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYK 230 Query: 231 -PFED--SNLTSL--YKKIFKAEFTCP----PWFS----ASAKKLIKRILDPNPATRIT 276 PF D N S +K+ + P WFS S KL+K NP+ R+T Sbjct: 231 PPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLT 289 >3CJF-A nrPDB Length = 309 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 67/283 (23%), Positives = 119/283 (42%), Gaps = 39/283 (13%) Query: 30 KYELGRTLGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + LG+ LG G F +V A VA+K++ KE ++ A + + Sbjct: 28 RLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML-KEGATHSEHRALMSELKILIH 86 Query: 85 LIKHPNVIRMFEVMASKTK----IYFVLEFVTGGELFDKISSNGR------------LKE 128 + H NV+ + + + TK + ++EF G L + S L Sbjct: 87 IGHHLNVVNL---LGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTL 143 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVRE 184 + Y Q+ +++ SR HRDL N+LL +K+ DFGL+ P VR+ Sbjct: 144 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK 203 Query: 185 -DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYK 242 D L ++APE I ++ Y ++D+WS GV+L+ + G P+ + + Sbjct: 204 GDARLPL-----KWMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 257 Query: 243 KIFK--AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + K P + + + + P+ R TF+E++E+ Sbjct: 258 RRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >5FQD-C nrPDB Length = 341 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 18/167 (10%) Query: 20 SSSGGRTRV---GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 SSSG + GKY+L R +G G+F + A N+ NG+ VA+K ++ +K +++ + Sbjct: 7 SSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKARHPQLLYES 65 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGG----ELFDKISSNGRLKEDEAR 132 K + P+ IR + + K Y VL G +LF+ S R Sbjct: 66 KLYKILQGGVGIPH-IRWY----GQEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVL 118 Query: 133 KYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN---GALKVSDFGLS 176 Q+I+ ++Y H++ HRD+KP+N L+ L + DFGL+ Sbjct: 119 MLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLA 165 >3REP-A nrPDB Length = 271 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 51/239 (21%), Positives = 109/239 (45%), Gaps = 18/239 (7%) Query: 53 NGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIY--FVLEF 110 G+++ +KV+ K + + E +++ HPNV+ + S + + + Sbjct: 32 QGNDIVVKVL-KVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHW 90 Query: 111 VTGGELFDKIS--SNGRLKEDEARKYFQQLINAVDYCHSRG--VYHRDLKPENLLLDANG 166 + G L++ + +N + + +A K+ + + + H+ + L ++++D + Sbjct: 91 MPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDM 150 Query: 167 ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK--ADLWSCGVILFV 224 ++S ++ + + G ++ P +VAPE + K D + AD+WS V+L+ Sbjct: 151 TARIS---MADVKFSFQSPGRMYA----PAWVAPEALQKKPEDTNRRSADMWSFAVLLWE 203 Query: 225 LMAGYLPFED-SNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 L+ +PF D SN+ K + T PP S KL+K ++ +PA R F ++ Sbjct: 204 LVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKRPKFDMIV 262 >3ZZW-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 61/271 (22%), Positives = 110/271 (40%), Gaps = 34/271 (12%) Query: 37 LGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 LGE F KV E VAIK + K+K + + + + E ++HPNV Sbjct: 17 LGEDRFGKVYKGHLFGPAPGEQTQAVAIKTL-KDKA-EGPLREEFRHEAMLRARLQHPNV 74 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKI------SSNGRLKEDEARK----------YF 135 + + V+ + + + + G+L + + S G +D K Sbjct: 75 VCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLV 134 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q+ ++Y S V H+DL N+L+ +K+SD GL LL + Sbjct: 135 AQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPI 194 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVL----MAGYLPFEDSNLTSLY--KKIFKAEF 249 ++APE I G +D+WS GV+L+ + + Y + + ++ + +++ Sbjct: 195 RWMAPEAI-MYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPD 253 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEV 280 CP W A L+ + P+ R F ++ Sbjct: 254 DCPAWVYA----LMIECWNEFPSRRPRFKDI 280 >5GRN-A nrPDB Length = 356 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 67/303 (22%), Positives = 125/303 (41%), Gaps = 50/303 (16%) Query: 33 LGRTLGEGTFAKV------KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 LGR LG G F KV +R+ + VA+K++ K + +I T L Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMT-HLG 107 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN------------------GRLKE 128 H N++ + IY + E+ G+L + + N L + Sbjct: 108 PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSD 167 Query: 129 DEAR--------KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 D + + Q+ +++ S+ HRDL N+LL +K+ DFGL+ + Sbjct: 168 DNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA---R 224 Query: 181 QVREDGLLHTTCGT---PNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSN 236 + D + T ++APE I + Y +D+WS G++L+ + G P+ Sbjct: 225 DIMHDSNYVSKGSTFLPVKWMAPESIFDNLYT-TLSDVWSYGILLWEIFSLGGTPYPGMM 283 Query: 237 LTSLYKKIFKAEFTC--PPWFSASAKKLIKRILDPNPATRITF---AEVIENEW---FKK 288 + S + K+ + P ++ +++ + + P R +F +E++EN +KK Sbjct: 284 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK 343 Query: 289 GYK 291 Y+ Sbjct: 344 SYE 346 >3KRL-A nrPDB Length = 335 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/277 (21%), Positives = 119/277 (42%), Gaps = 34/277 (12%) Query: 32 ELGRTLGEGTFAKVKFARNVENG-DNVAIKVIDKEKVLKNKMIAQIKREI-STMKLI--- 86 + G+TLG G F KV A G ++ +KV K+LK+ A K + S +K++ Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKV--AVKMLKSTAHADEKEALMSELKIMSHL 106 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI----------------SSNGRLKED 129 +H N++ + + + E+ G+L + + + +L Sbjct: 107 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSR 166 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--L 187 + + Q+ + + S+ HRD+ N+LL K+ DFGL+ + + D + Sbjct: 167 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA---RDIMNDSNYI 223 Query: 188 LHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIF 245 + P ++APE I + Y ++D+WS G++L+ + G P+ + S + K+ Sbjct: 224 VKGNARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV 282 Query: 246 K--AEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 K + P + + +++ P R TF ++ Sbjct: 283 KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >5E8V-A nrPDB Length = 316 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 24/197 (12%) Query: 26 TRVGKYELGRTLGEGTFAKV---KFARNV-ENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 T + EL +G+G FA+V K +N E + VA+K+ E+ K I +I+ Sbjct: 6 TELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN 65 Query: 82 TMKLIKHPNVIRMFEVMASKTKI----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 +KH N+++ KT++ + + F G L + ++ + ED RK Sbjct: 66 ----LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWED-LRKLGSS 120 Query: 138 LINAVDYCHSRG---------VYHRDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGL 187 L + + HS + HRDLK N+L+ + + DFGLS L + D L Sbjct: 121 LARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDL 180 Query: 188 LHT-TCGTPNYVAPEVI 203 ++ GT Y+APEV+ Sbjct: 181 ANSGQVGTARYMAPEVL 197 >3VHK-A nrPDB Length = 368 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 74/158 (46%), Gaps = 14/158 (8%) Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS----ALPQQVRE-DGLL 188 Y Q+ +++ SR HRDL N+LL +K+ DFGL+ P VR+ D L Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFK- 246 ++APE I ++ Y ++D+WS GV+L+ + G P+ + + + K Sbjct: 265 PL-----KWMAPETIFDRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKE 318 Query: 247 -AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 P + + + + P+ R TF+E++E+ Sbjct: 319 GTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 >6BSD-A nrPDB Length = 876 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/203 (23%), Positives = 82/203 (40%), Gaps = 45/203 (22%) Query: 15 STPSGSSSGGRTRV----GKYELGRTLGEGTFAKVK--------------FARNVENGDN 56 + P G+ G RV + LGEG F +V F NV G Sbjct: 553 ALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHP 612 Query: 57 --VAIKVI--DKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVT 112 VA+K++ D K +N + +E+ M +K PN+IR+ V + + +++ Sbjct: 613 LLVAVKILRPDATKNARNDFL----KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME 668 Query: 113 GGELFDKISS-------------NGRLKEDEARKY------FQQLINAVDYCHSRGVYHR 153 G+L +S+ +G+ + Y Q+ + + Y + HR Sbjct: 669 NGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHR 728 Query: 154 DLKPENLLLDANGALKVSDFGLS 176 DL N L+ N +K++DFG+S Sbjct: 729 DLATRNCLVGENFTIKIADFGMS 751 >4TN6-A nrPDB Length = 318 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 100/220 (45%), Gaps = 22/220 (10%) Query: 27 RVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 RVG +Y LGR +G G+F + ++ G+ VAIK+ + +K K Q+ E K+ Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKH-PQLHIESKIYKM 58 Query: 86 IKHPNVIRMFEVMASKTKI-YFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAV 142 ++ I ++ V+E + +LF+ S LK Q+I+ + Sbjct: 59 MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKT--VLLLADQMISRI 116 Query: 143 DYCHSRGVYHRDLKPENLL--LDANGAL-KVSDFGLSALPQQVREDGLL-----HTTCGT 194 +Y HS+ HRD+KP+N L L G L + DFGL+ + R + GT Sbjct: 117 EYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGT 176 Query: 195 PNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 Y + + + G + ++ DL S G +L G LP++ Sbjct: 177 ARYAS--INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQ 214 >5VC6-A nrPDB Length = 289 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 94/233 (40%), Gaps = 38/233 (16%) Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRL----KEDEAR 132 RE+ ++ +H +V+R F A + E+ GG L D IS N R+ KE E + Sbjct: 59 REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELK 118 Query: 133 KYFQQLINAVDYCHSRGVYHRDLKPENLLLD----ANGA---------------LKVSDF 173 Q+ + Y HS + H D+KP N+ + N A K+ D Sbjct: 119 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDL 178 Query: 174 G--LSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 G QV E G ++A EV+ KAD+++ + + V AG P Sbjct: 179 GHVTRISSPQVEE--------GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEP 229 Query: 232 FEDSNLTSLYKKIFKAEFT-CPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + + +I + P S +L+K ++ P+P R + ++++ Sbjct: 230 LPRNG--DQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >3MY0-A nrPDB Length = 305 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 51/224 (22%), Positives = 103/224 (45%), Gaps = 32/224 (14%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI---DKEKVLKNKMIAQIKR 78 S RT + L +G+G + +V R + +G++VA+K+ D++ + + Sbjct: 1 SMQRTVARQVALVECVGKGRYGEV--WRGLWHGESVAVKIFSSRDEQSWFR-------ET 51 Query: 79 EISTMKLIKHPNVIRMFEV-MASK---TKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 EI L++H N++ M S+ T+++ + + G L+D + L+ A + Sbjct: 52 EIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-LEPHLALRL 110 Query: 135 FQQLINAVDYCHSR--------GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE-- 184 + + H + HRD K N+L+ +N ++D GL+ + Q + Sbjct: 111 AVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYL 170 Query: 185 DGLLHTTCGTPNYVAPEVINNK----GYDGAK-ADLWSCGVILF 223 D + GT Y+APEV++ + ++ K D+W+ G++L+ Sbjct: 171 DIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW 214 >6FER-A nrPDB Length = 309 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 18/167 (10%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKV----IDKEKVLKNKMIAQIKRE 79 G + G+ L G F FA +V V + V D K +N + +E Sbjct: 18 GEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFL----KE 73 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS---------SNGRLKEDE 130 I M +K PN+I + V + + + E++ G+L +S S+ R Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYT 133 Query: 131 ARKYFQ-QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS 176 K+ Q+ + + Y S HRDL N L+ N +K++DFG+S Sbjct: 134 NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMS 180 >6FEX-A nrPDB Length = 321 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/189 (23%), Positives = 78/189 (41%), Gaps = 25/189 (13%) Query: 7 PSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDN--VAIKVI-- 62 P R RS G + G+ L + F NV G VA+K++ Sbjct: 8 PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 67 Query: 63 DKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 D K +N + +E+ M +K PN+IR+ V + + +++ G+L +S+ Sbjct: 68 DATKNARNDFL----KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 123 Query: 123 NGRLKEDEARK---------------YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA 167 + ED+A + Q+ + + Y + HRDL N L+ N Sbjct: 124 HQ--LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 181 Query: 168 LKVSDFGLS 176 +K++DFG+S Sbjct: 182 IKIADFGMS 190 >2ZFD-B nrPDB Length = 123 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 34/97 (35%), Positives = 49/97 (50%), Gaps = 6/97 (6%) Query: 333 MNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDV-KTN 391 MNAF++IS S G NL LF R RF S +A +V ++E + V K Sbjct: 6 MNAFDIISGSPGFNLSGLFGDARKY-DRVERFVSAWTAERVVERLEEIVSAENLTVAKKE 64 Query: 392 NYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRK 428 + MK+ G+ KG A+ E+ Q+ L M+E+RK Sbjct: 65 TWGMKIEGQ----KGNFAMVVEINQLTDELVMIEVRK 97 >4XHH-A nrPDB Length = 403 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 54/236 (22%) Query: 27 RVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 RVG K+ +GR +G G+F + N+ +G+ VAI+ + I+ Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIR------------LESIRS------- 44 Query: 86 IKHPNV---IRMFEVMASKTKIYFVLEFVTGGE----LFDKISSNGRLKEDEARKYFQ-- 136 +HP + R+++ ++ I F+ F GE + D + + + + F Sbjct: 45 -RHPQLDYESRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFK 103 Query: 137 -------QLINAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQV---- 182 Q+I V Y H R HRD+KP+N L+ + V DFGLS + Sbjct: 104 TVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR 163 Query: 183 ----REDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 RE+ L GT Y + V + G + ++ DL S G +L G LP++ Sbjct: 164 HIPYRENKSL---TGTARYAS--VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQ 214 >4NT4-A nrPDB Length = 312 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 72/326 (22%), Positives = 143/326 (43%), Gaps = 52/326 (15%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-KHP 89 + +G+ +G G F +++ +N+ N ++VAIK+ + +K+K Q+ E KL+ H Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKA-PQLHLEYRFYKLLGSHA 68 Query: 90 N-----VIRMFEVMASKTKI-YFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINA 141 + + R++ + + VLE + + +LF+ + LK +QL++ Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKT--VLMIAKQLLHR 126 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGA-----LKVSDFGLSALPQQVREDGLLH------- 189 ++Y HSR + +RD+KPEN L+ + + DFGL+ + + D H Sbjct: 127 IEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK--EYIDLDTNRHIPYREHK 184 Query: 190 TTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFED---SNLTSLYKKIF 245 + GT Y++ + + G + ++ DL + G + + G LP++ L Y+KI Sbjct: 185 SLTGTARYMS--INTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIG 242 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDV 305 + P I+ + D +P T+ + F ++ P ++ D Sbjct: 243 DTKRATP----------IEVLCDGHPEEFATYLRYVRRLDF---FETPDYDFLRRLFQD- 288 Query: 306 DAIFDDSGESKNLVVERREEGLKTPV 331 +FD G + + + + TPV Sbjct: 289 --LFDRKGYTDEGEFDWTGKTMSTPV 312 >4WUA-A nrPDB Length = 401 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 20/152 (13%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G+Y + R LG G F+ V + +++ VA+KV+ + + EI +K +++ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETAL----DEIRLLKSVRN 96 Query: 89 -----PN---VIRMFEVM----ASKTKIYFVLEFVTGGELFDKI--SSNGRLKEDEARKY 134 PN V+++ + + T I V E V G L I S+ L +K Sbjct: 97 SDPNDPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKI 155 Query: 135 FQQLINAVDYCHSRG-VYHRDLKPENLLLDAN 165 QQ++ +DY H++ + H D+KPEN+LL N Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVN 187 >4L00-A nrPDB Length = 304 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 72/282 (25%), Positives = 125/282 (44%), Gaps = 39/282 (13%) Query: 27 RVGKYEL--GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS--- 81 R+ K +L G LG GT + ++ D+ K KV+ K++ R+IS Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVIL-KVLDPSHRDISLAF 79 Query: 82 -----TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKY 134 M+ + H +++ ++ V + V EFV GG +LF S+ L K Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDV-LTTPWKFKV 138 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-------LKVSDFGLSALPQQV--RED 185 +QL +A+ Y + + H ++ +NLLL G +K+SD G +P V R++ Sbjct: 139 AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPG---IPITVLSRQE 195 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI 244 + ++APE + + AD WS G L+ + G +P +D L + K+ Sbjct: 196 CIERIP-----WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL--IEKER 248 Query: 245 FKAEFTCPPWFSASAKK---LIKRILDPNPATRITFAEVIEN 283 F E C P + S K+ L+ R ++ +P R F ++ + Sbjct: 249 F-YESRCRP-VTPSCKELADLMTRCMNYDPNQRPFFRAIMRD 288 >5KMM-A nrPDB Length = 329 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/252 (21%), Positives = 96/252 (38%), Gaps = 24/252 (9%) Query: 37 LGEGTFAKVKFA--RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 LGEG F KV A N+ + + + K +RE + +++H +++R Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 102 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSN---------------GRLKEDEARKYFQQLI 139 F V + V E++ G+L + S+ G L + Q+ Sbjct: 103 FGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVA 162 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + Y HRDL N L+ +K+ DFG+S + T ++ Sbjct: 163 AGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMP 222 Query: 200 PEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKI-----FKAEFTCPP 253 PE I + + ++D+WS GV+L+ + G P+ + T I + CPP Sbjct: 223 PESILYRKFT-TESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPP 281 Query: 254 WFSASAKKLIKR 265 A + +R Sbjct: 282 EVYAIMRGCWQR 293 >5X18-A nrPDB Length = 295 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 105/228 (46%), Gaps = 30/228 (13%) Query: 24 GRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G T VG Y++G+ +GEG+F + N+ NG VAIK ++ Q++ E T Sbjct: 1 GSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRK-----TEAPQLRDEYKT 55 Query: 83 MKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLIN 140 K++ PN+ + V++ + G L D GR + Q+I Sbjct: 56 YKILNGTPNIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMIT 114 Query: 141 AVDYCHSRGVYHRDLKPENLLL------DANGALKVSDFGLSALPQQVREDGLLH----- 189 ++ H+ + +RD+KP+N L+ DAN + + DFG++ +Q R+ Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANN-IHLIDFGMA---KQYRDPKTKQHIPYR 170 Query: 190 ---TTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 + GT Y++ + + G + ++ D+ + G + F + G+LP++ Sbjct: 171 EKKSLSGTARYMS--INTHLGREQSRRDDMEALGHVFFYFLRGHLPWQ 216 >4XHL-A nrPDB Length = 394 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 97/236 (41%), Gaps = 54/236 (22%) Query: 27 RVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 RVG K+ +GR +G G+F + N+ +G+ VAI+ + I+ Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIR------------LESIRS------- 44 Query: 86 IKHPNV---IRMFEVMASKTKIYFVLEFVTGGE----LFDKISSNGRLKEDEARKYFQ-- 136 +HP + R++ ++ I F+ F GE + D + + + + F Sbjct: 45 -RHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFK 103 Query: 137 -------QLINAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQV---- 182 Q+ + Y H R HRD+KP+N L+ + V DFGLS + Sbjct: 104 TVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR 163 Query: 183 ----REDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 RE+ L GT Y + V + G + ++ DL S G +L G LP++ Sbjct: 164 HIPYRENKSL---TGTARYAS--VNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQ 214 >6BFN-A nrPDB Length = 342 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 80/206 (38%), Gaps = 17/206 (8%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKHPNVIRMF 95 +GEG F V R V A+K + + L+ + Q E+ + +HPN++ Sbjct: 30 IGEGGFGCVY--RAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 87 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLINAVDYCH--SRG 149 A V F+ G L D++ + L + A+ + H S Sbjct: 88 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSAL-------PQQVREDGLLHTTCGTPNYVAPEV 202 + H D+K N+LLD K+ DFGL+ P Q T GT Y+ E Sbjct: 148 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 207 Query: 203 INNKGYDGAKADLWSCGVILFVLMAG 228 I G D +S GV++ +AG Sbjct: 208 IKT-GRLAVDTDTFSFGVVVLETLAG 232 >5VDK-A nrPDB Length = 297 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 94/223 (42%), Gaps = 29/223 (13%) Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN----GRLKEDEARKYFQQLIN 140 L HP+V+R + A + E+ GG L IS N +E + + Q+ Sbjct: 71 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 130 Query: 141 AVDYCHSRGVYHRDLKPENLLL------DANGALK----VSDFGLSALPQQVREDGLLHT 190 ++Y H+ + H D+KP N+ + +++G ++ +D+ LSA D L H Sbjct: 131 GLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGD-LGHA 189 Query: 191 TC--------GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLY 241 T G ++A E++ KAD+++ G+ + V A LP + + Sbjct: 190 TSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNG----AAW 245 Query: 242 KKIFKAEFT-CPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 I K F P S S L+K ++ P+ R + A + N Sbjct: 246 HHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARN 288 >5AR8-A nrPDB Length = 326 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 10/210 (4%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R L G V AR+ + VA+K + L + + RE + + ++ + Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 95 FEVMASKTKIYFVLEFVTGG---ELFDKISSNGRLKEDEARKYFQQLINAVDYCH--SRG 149 + + V E++ G EL + + + + ++ V+Y H + Sbjct: 98 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC---GTPNYVAPEVIN-- 204 + H DLK +N+LLD +K++DFGLS + GT Y+ PE Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG 217 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFED 234 K K D++S VI + +++ PFED Sbjct: 218 QKSRASIKHDIYSYAVITWEVLSRKQPFED 247 >5OAT-A nrPDB Length = 411 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 24/175 (13%) Query: 142 VDYCHSRGVYHRDLKPENLLLDA----NGALKVSDFGLSALPQQVREDGLLHTTC----- 192 V + + G+ HRDLK +NLLLD + L +SDFG L + L +T+ Sbjct: 166 VAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFG-CCLADKTNGLSLPYTSYEMDKG 224 Query: 193 GTPNYVAPEVINNKG-----YDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSL-YKK-- 243 G +APE+I K + +KADLW+ G I + + + PF S L + YK+ Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGD 284 Query: 244 IFKAEFTCPPWFSASAKKLIKR----ILDPNPATRIT-FAEVIENEWFKKGYKAP 293 + K P A L+KR LDP A + + W K G K P Sbjct: 285 LPKLPDEVPTVIQALVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVP 339 >4NFN-A nrPDB Length = 309 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 22/216 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 ++++ + +G G F ++ A ++ +NVA+KV E + K + +K E++ +K ++ Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQGK 76 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHS 147 + + F K +V+ + G L D + G + +Q++ +++ HS Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 148 RGVYHRDLKPENLLLDANGALKVS-------DFGLSA----LPQQVREDGLLHTTCGTPN 196 G HRD+KP N A G L + DFGL+ VR + GT Sbjct: 137 VGFLHRDIKPSNF---AMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 193 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 Y + N+ G DLWS +L G LP+ Sbjct: 194 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 228 >4BTK-A nrPDB Length = 337 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 22/216 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 ++++ + +G G F ++ A ++ +NVA+KV E + K + +K E++ +K ++ Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQGK 111 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHS 147 + + F K +V+ + G L D + G + +Q++ +++ HS Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 148 RGVYHRDLKPENLLLDANGALKVS-------DFGLSA----LPQQVREDGLLHTTCGTPN 196 G HRD+KP N A G L + DFGL+ VR + GT Sbjct: 172 VGFLHRDIKPSNF---AMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 228 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 Y + N+ G DLWS +L G LP+ Sbjct: 229 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 263 >3G2F-A nrPDB Length = 336 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 89/208 (42%), Gaps = 33/208 (15%) Query: 77 KREISTMKLIKHPNVIRMF----EVMAS-KTKIYFVLEFVTGGELFDKIS-------SNG 124 ++ I + L++H N+ R V A + + V+E+ G L +S S+ Sbjct: 55 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC 114 Query: 125 RLKEDEAR--KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA----- 177 RL R Y + D+ + + HRDL N+L+ +G +SDFGLS Sbjct: 115 RLAHSVTRGLAYLHTELPRGDH-YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGN 173 Query: 178 -LPQQVREDGLLHTTCGTPNYVAPEV----INNKGYDGA--KADLWSCGVI---LFVLMA 227 L + ED + GT Y+APEV +N + + A + D+++ G+I +F+ Sbjct: 174 RLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCT 233 Query: 228 GYLPFEDSNLTSLYKKIFKAEFTCPPWF 255 P E Y+ F+ E P F Sbjct: 234 DLFPGES---VPEYQMAFQTEVGNHPTF 258 >6J6I-B nrPDB Length = 351 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 55/100 (55%), Gaps = 12/100 (12%) Query: 136 QQLINAVDYCHS---RGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQ---QVREDGLL 188 +++ NAV Y H+ + + HRD+KP ++ LD N K+SD S +LP+ ++ + +L Sbjct: 170 KEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVL 229 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 228 GT Y+ P + + + D++S G+ L V++ G Sbjct: 230 ----GTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITG 264 >4M69-B nrPDB Length = 283 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 70/163 (42%), Gaps = 9/163 (5%) Query: 79 EISTMKLIKHPNVIRMFEVMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 EI TMK PN++R+F + +T + V+E+ G L + + L Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 117 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--LLHTTC 192 + + H HR++ + L+ +K++ F LS + Sbjct: 118 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 177 Query: 193 GTPNYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFE 233 + YV+PE + N YD KA+++S G++L+ + G +PFE Sbjct: 178 SSTIYVSPERLKNPFCLYD-IKAEIYSFGIVLWEIATGKIPFE 219 >3ZBF-A nrPDB Length = 322 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 99/237 (41%), Gaps = 35/237 (14%) Query: 30 KYELGRTLGEGTFAKVKFARNVE-----NGD-NVAIKVIDKEKVLKNKMIAQIKREISTM 83 K L LG G F +V V+ +G+ VA+K + K + K+ + +E M Sbjct: 34 KLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHLM 91 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKE--DEARKYFQQLINA 141 HPN+++ V Y +LE + GG+L + R+ + Sbjct: 92 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK-ARMATFYGPLLTLVDLVDLC 150 Query: 142 VD------YCHSRGVYHRDLKPENLLLDANG-----ALKVSDFGLSALP-----QQVRED 185 VD Y HRDL N L+ +K+ DFGL+ + R + Sbjct: 151 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 210 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE-DSNLTSL 240 GLL ++APE + + G ++D+WS G++++ +L G+ P+ SNL L Sbjct: 211 GLLPV-----RWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 >5X1R-A nrPDB Length = 302 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 93/244 (38%), Gaps = 37/244 (15%) Query: 13 SRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK- 71 S S PSG R ++E+ +GEG F V A + + +AIK + K Sbjct: 11 SNSLPSG------YRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRND 64 Query: 72 --------------MIAQIKREISTMKLI---KHPNVIRMFEVMASKTKIYFVLEFVTGG 114 A + I +L+ HP ++ + Y +F +G Sbjct: 65 DLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGT 124 Query: 115 ELFDKISSNGRLKEDEA--RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSD 172 L + + K DEA R+ L +A++ H G HRD+ +N+ + + + D Sbjct: 125 TL-KNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLD 183 Query: 173 FGLSALPQQVREDGLLHTTCGT---PNYVAPEVI--NNKGYDGAKADLWSCGVILFVLMA 227 FG + +E G L P + E N+ G G D+++ G +L L+ Sbjct: 184 FGSAR-----KEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIV 238 Query: 228 GYLP 231 G P Sbjct: 239 GSPP 242 >4BTF-A nrPDB Length = 469 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 75/171 (43%), Gaps = 25/171 (14%) Query: 79 EISTMKLIKHPNVIRMFEVMASKT----KIYFVLEFVTGG---ELFDK-----ISSNGRL 126 EI TMK PN++R+F + +T + V+E+ G EL D+ +S L Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 303 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 AR ++ H HR++ + L+ +K++ F LS + Sbjct: 304 VLRAARGLYR--------LHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTA 355 Query: 187 --LLHTTCGTPNYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFE 233 + YV+PE + N YD KA+++S G++L+ + G +PFE Sbjct: 356 KSTKAERSSSTIYVSPERLKNPFCLYD-IKAEIYSFGIVLWEIATGKIPFE 405 >5CLR-A nrPDB Length = 451 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 57/107 (53%), Gaps = 10/107 (9%) Query: 101 KTKIYFVLE-FVTGGELF---DKISSNGRLKED-EARKYFQQLINAVDYCHSRGVYHRDL 155 +T+++++L F+ G +L + + N LK E + + V H G+ HRDL Sbjct: 143 QTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDL 202 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 KP N++LDA+ + DFG S+ ++ + + GT +Y+APE+ Sbjct: 203 KPGNIMLDADMQCHLVDFGSSSSDKEPKP-----ASWGTASYLAPEL 244 >2X7G-A nrPDB Length = 389 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 25/172 (14%) Query: 17 PSGSSSGGRTRV-------GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK 69 P+ GG V G+Y + R LG G F+ V +++ VA+KV+ + Sbjct: 12 PADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYT 71 Query: 70 NKMIAQIKREISTMKLIKH-----PN---VIRMFE--VMASKTKIYFVLEF-VTGGELFD 118 + +IK +K ++ PN V+++ + ++ I+ + F V G L Sbjct: 72 ETALDEIK----LLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLK 127 Query: 119 KI--SSNGRLKEDEARKYFQQLINAVDYCHSRG-VYHRDLKPENLLLDANGA 167 I S+ L + +Q++ +DY HS+ + H D+KPEN+L+ + A Sbjct: 128 WIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDA 179 >2C47-A nrPDB Length = 313 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 73/154 (47%), Gaps = 15/154 (9%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVID-KEKVLKNKMIAQIKREISTMKLIKHP 89 + +G+ +G G F +++ +N+ + VAIK+ K + + + + +++S + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATE----- 60 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 V +++ VLE + +LFD LK QLI ++Y H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKT--VLMIAIQLITRMEYVHT 118 Query: 148 RGVYHRDLKPENLLLDANG-----ALKVSDFGLS 176 + + +RD+KPEN L+ G A+ + DFGL+ Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLA 152 >3AOX-A nrPDB Length = 344 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 58/269 (21%), Positives = 99/269 (36%), Gaps = 24/269 (8%) Query: 33 LGRTLGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 L R LG G F +V + N + VA+K + +V + E + Sbjct: 51 LIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL--PEVCSEQDELDFLMEALIISKFN 108 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGEL-------FDKISSNGRLKEDEARKYFQQLIN 140 H N++R V + +LE + GG+L + S L + + + Sbjct: 109 HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC 168 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANG---ALKVSDFGLSALPQQVREDGLLHTTCG--TP 195 Y HRD+ N LL G K+ DFG++ R C Sbjct: 169 GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR--DIYRASYYRKGGCAMLPV 226 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW 254 ++ PE +G +K D WS GV+L+ + GY+P+ + + + + PP Sbjct: 227 KWMPPEAF-MEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPK 285 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIE 282 +++ + P R FA ++E Sbjct: 286 NCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >6EQI-C nrPDB Length = 433 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 62/261 (23%), Positives = 106/261 (40%), Gaps = 54/261 (20%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKV-----LKNKMIAQIKREISTMK--LIKHP 89 L K+ F +VE+ +K + +E V N+ + I+ IS K L HP Sbjct: 44 LAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMSYFFNQNLFNIE-NISDFKIRLPPHP 102 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-----------RLKEDEARKYFQQ- 137 N++RM+ V A + + + L +I+ G + + ++Y + Sbjct: 103 NIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDK 162 Query: 138 -------------LINAVDYCHSRGVYHRDLKPENLLL-----DANGALKVSDFGLSALP 179 L+ AV + + + HRDLK +N+L+ DA + ++DFG Sbjct: 163 TPNMRSSILLLSQLLEAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCD 222 Query: 180 QQVREDGLL-------HTTCGTPNYVAPEVINNK-----GYDGAKADLWSCGVILFVLMA 227 +Q +GL+ G +APE+ N K + K+DLW+ G I + + Sbjct: 223 KQ---NGLVIPYRSEDQDKGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFN 279 Query: 228 GYLPFEDSNLTSLYKKIFKAE 248 PF D + L K +K E Sbjct: 280 IDNPFYDKTM-KLLSKSYKEE 299 >5USZ-A nrPDB Length = 289 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 108/276 (39%), Gaps = 43/276 (15%) Query: 33 LGRTLGEGTFAKVKFARNVENGD-------NVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 +LG+GTF K+ E GD V +KV+DK S M Sbjct: 12 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAH---RNYSESFFEAASMMSK 68 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLINA 141 + H +++ + V + V EFV G L + N L + E K QL A Sbjct: 69 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK---QLAAA 125 Query: 142 VDYCHSRGVYHRDLKPENLLL-------DANGA-LKVSDFGLS--ALPQQVREDGLLHTT 191 + + + H ++ +N+LL N +K+SD G+S LP+ + ++ + Sbjct: 126 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---- 181 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK----KIFKA 247 +V PE I N D WS G L+ + +G D L++L + ++ Sbjct: 182 ----PWVPPECIENPKNLNLATDKWSFGTTLWEICSG----GDKPLSALDSQRKLQFYED 233 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 P +A LI +D P R +F +I + Sbjct: 234 RHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRD 269 >4MWI-A nrPDB Length = 294 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 93/202 (46%), Gaps = 34/202 (16%) Query: 57 VAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKHPNVIRMFEVMASKT----KIYFVLEFV 111 VAIKV K + ++ Q +EI TMK + PN++R+F + +T + V+E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 112 TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVY----------HRDLKPENLL 161 G L + + R K+ K ++ A +RG+Y H ++ N L Sbjct: 110 ELGTLRELLD---REKDLTLGKRMVLVLGA-----ARGLYRLHHSEAPELHGKIRSSNFL 161 Query: 162 LDANGALKVSDFGLSALPQQVREDGLLHTT------CGTPNYVAPEVINNKGYD-GAKAD 214 + +K++ F L ++ + L TT + Y++P+ + + Y K++ Sbjct: 162 VTQGYQVKLAGFEL----RKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSE 217 Query: 215 LWSCGVILFVLMAGYLPFEDSN 236 ++S G++L+ + G +PF+ N Sbjct: 218 IYSFGIVLWEIATGDIPFQGCN 239 >2CHL-A nrPDB Length = 351 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 103/243 (42%), Gaps = 29/243 (11%) Query: 21 SSGGRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S G VG + +G+ +G G F +++ +N+ + VAIK+ + +K++ Q+ E Sbjct: 21 QSMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPMKSR-APQLHLE 75 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKI-YFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQ 136 K + + I K VLE + +LFD LK Sbjct: 76 YRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKT--VLMIAI 133 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANG-----ALKVSDFGLSALPQQVREDGLLH-- 189 QLI+ ++Y HS+ + +RD+KPEN L+ G + + DF L+ + + + H Sbjct: 134 QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK--EYIDPETKKHIP 191 Query: 190 -----TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLY 241 + GT Y++ K + DL + G + + G LP++ L Y Sbjct: 192 YREHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY 250 Query: 242 KKI 244 +KI Sbjct: 251 QKI 253 >4OAU-C nrPDB Length = 699 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 35/163 (21%) Query: 127 KEDE-ARKYFQQLINAVDYCH-SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 +EDE AR + AV H S G H+DL+P+N+L+D+ A ++DF S Sbjct: 436 EEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSI------- 488 Query: 185 DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCG-VILFVLMAGYLPFEDSNLTSLYKK 243 G P V K DL G ++L+V+ G + FED S + Sbjct: 489 -----KWAGDPQEV-------------KRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEV 530 Query: 244 IFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 + P K LI R+ P R ++++ + +F Sbjct: 531 V-----QLSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 566 >1CSN-A nrPDB Length = 298 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 102/236 (43%), Gaps = 42/236 (17%) Query: 22 SGGRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 SG VG Y++GR +GEG+F + N+ N VAIK + Q++ E Sbjct: 2 SGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSD-----APQLRDEY 56 Query: 81 STMKLIKH----PNVIRMFEVMASKTKIYFVLEF-VTGGELFDKISSNGR-LKEDEARKY 134 T KL+ PNV + ++ VL + G L D + GR Sbjct: 57 RTYKLLAGCTGIPNVYYF-----GQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMA 111 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLL------DANGALKVSDFGL----------SAL 178 +Q++ V H + + +RD+KP+N L+ +AN + V DFG+ + Sbjct: 112 AKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNAN-MIYVVDFGMVKFYRDPVTKQHI 170 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAGYLPFE 233 P + +++ GT Y++ + + G + ++ DL + G + + G LP++ Sbjct: 171 PYREKKN-----LSGTARYMS--INTHLGREQSRRDDLEALGHVFMYFLRGSLPWQ 219 >2CMW-A nrPDB Length = 310 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 99/243 (40%), Gaps = 53/243 (21%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 +G+ +G G F +++ +N+ + VAIK + IK + L Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIK------------LEPIKSRAPQLHL-----EY 46 Query: 93 RMFEVMASK----TKIYF----------VLEFVTGG--ELFDKISSNGRLKEDEARKYFQ 136 R ++ + S ++Y+ VLE + +LFD LK Sbjct: 47 RFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKT--VLMIAI 104 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANG-----ALKVSDFGLSALPQQVREDGLLH-- 189 QL++ ++Y HS+ + +RD+KPEN L+ G + + DFGL+ + + + H Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK--EYIDPETKKHIP 162 Query: 190 -----TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLY 241 + GT Y++ K + DL + G + + G LP++ L Y Sbjct: 163 YREHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY 221 Query: 242 KKI 244 +KI Sbjct: 222 QKI 224 >4O1O-A nrPDB Length = 717 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 9/92 (9%) Query: 127 KEDE-ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL----PQQ 181 +EDE AR L A+ H G H+DL+P+N+L+D+ ++DF S PQ+ Sbjct: 439 EEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQK 498 Query: 182 VRED----GLLHTTCGTPNYVAPEVINNKGYD 209 ++ D GLL ++ E + N+ ++ Sbjct: 499 IKRDLEALGLLVLYVVKKGDISFETLKNQSFE 530 >4RT7-A nrPDB Length = 415 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 59/120 (49%), Gaps = 12/120 (10%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--LLHTTCGT 194 Q+ +++ + HRDL N+L+ +K+ DFGL+ + + D ++ Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA---RDIMSDSNYVVRGNARL 307 Query: 195 P-NYVAPEVINNKGYDGAKADLWSCGVILF-VLMAGYLPFE----DSNLTSLYKKIFKAE 248 P ++APE + +G K+D+WS G++L+ + G P+ D+N L + FK + Sbjct: 308 PVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMD 366 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 6/96 (6%) Query: 32 ELGRTLGEGTFAKVKFA-----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 E G+ LG G F KV A VA+K++ KEK ++ A + +L Sbjct: 68 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMMTQLG 126 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 H N++ + IY + E+ G+L + + S Sbjct: 127 SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRS 162 >3DZO-A nrPDB Length = 413 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 86/219 (39%), Gaps = 36/219 (16%) Query: 58 AIKVIDKEKVLKNKMIAQIK---------REISTMKLIKHPNVIRMFEVMASKTKIYFVL 108 AIK + KE+VL+ +++ IK R I L+K P +M V + ++ + Sbjct: 121 AIKQM-KEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLS 179 Query: 109 EFV----------TGGELFDKISSNGRLKEDEAR-KYFQQLINAVDYCHSRGVYHRDLKP 157 F T GE+ SS + AR + Q+I + H G+ H L+P Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 239 Query: 158 ENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA---- 213 +++LD G + ++ F + + DG + + PE + + Sbjct: 240 VDIVLDQRGGVFLTGF------EHLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTL 293 Query: 214 -----DLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA 247 D W+ G+ ++ + LP D + IF++ Sbjct: 294 MTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRS 332 >3BYV-A nrPDB Length = 377 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 45/204 (22%), Positives = 84/204 (41%), Gaps = 37/204 (18%) Query: 58 AIKVIDKEKVLKNKMIAQIK---------REISTMKLIKHPNVIRMFEVMASKTKIYFVL 108 AIK + KE+VL+ +++ IK R I L+K P +M V + ++ + Sbjct: 116 AIKQM-KEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLS 174 Query: 109 EFV----------TGGELFDKISSNGRLKEDEAR-KYFQQLINAVDYCHSRGVYHRDLKP 157 F T GE+ SS + AR + Q+I + H G+ H L+P Sbjct: 175 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 234 Query: 158 ENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG---YDGAKA- 213 +++LD G + ++ F + + DG + + + PE+ + Y + Sbjct: 235 VDIVLDQRGGVFLTGF------EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRT 288 Query: 214 ------DLWSCGVILFVLMAGYLP 231 D W+ G++++ + LP Sbjct: 289 LMTFSFDAWALGLVIYWIWCADLP 312 >4IX6-A nrPDB Length = 350 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%) Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSAL 178 +K ++L+ ++ H GV HRD+KP NL+ G LK+ D G +AL Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 >6G4J-A nrPDB Length = 315 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 73/167 (43%), Gaps = 24/167 (14%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G++ G+ Y L + LG+G V A + +VA+KV D I Sbjct: 16 GTTIKGKWNGNTYTLRKQLGKGANGIVYLAETSDG--HVALKVSDDS--------LSITS 65 Query: 79 EISTMKLIKHPNVIRM----FE-----VMASKTKI-YFVLEFVTGGELFDKISSNGRLKE 128 E++ +K + M F+ + ++ TK+ ++ +E++ G L +S G Sbjct: 66 EVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG---A 122 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-LKVSDFG 174 + QL++++ H +G DLKP+NL++ A ++ D G Sbjct: 123 EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >2RSV-A nrPDB Length = 403 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 24/114 (21%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVS--DFGLSAL-------------PQQ 181 ++++ ++Y H H D+K NLLL+ +V D+GL+ P++ Sbjct: 167 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 226 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 + + T+ N VAP + DL G + + G+LP+ED+ Sbjct: 227 CHDGTIEFTSIDAHNGVAP---------SRRGDLEILGYCMIQWLTGHLPWEDN 271 >2LAV-A nrPDB Length = 361 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 24/114 (21%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVS--DFGLSAL-------------PQQ 181 ++++ ++Y H H D+K NLLL+ +V D+GL+ P++ Sbjct: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 219 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 + + T+ N VAP + DL G + + G+LP+ED+ Sbjct: 220 CHDGTIEFTSIDAHNGVAP---------SRRGDLEILGYCMIQWLTGHLPWEDN 264 >5UV4-A nrPDB Length = 311 Score = 35.0 bits (79), Expect = 0.066, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 34/202 (16%) Query: 47 FARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI--RMFEVMASKTKI 104 + ++NG + +K + KE K+K + REI + ++HPN++ R + + + Sbjct: 42 YKATLDNGYMLTVKWL-KEGFAKSK--KEFSREIKKLGSVRHPNLVPLRGYYWGPKEHER 98 Query: 105 YFVLEFVTGGEL------FDK-----ISSNGRLK--EDEARKYFQQLINAVDYCHS-RGV 150 + ++ L FD+ +S+ RL D AR +DY H+ R + Sbjct: 99 IMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIAR--------CLDYLHNERVI 150 Query: 151 YHRDLKPENLLL-DANGALKVSDFGLSAL--PQQVREDGLLHTTCGTPNYVAPEVIN-NK 206 H ++K N+L+ ++ + V+D+ L L P + E L G Y PE + +K Sbjct: 151 PHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVL---NAGALGYSPPEFSSTSK 207 Query: 207 GYDGAKADLWSCGVILFVLMAG 228 K+D+++ GVIL L+ G Sbjct: 208 PCPSLKSDVYAFGVILLELLTG 229 >4AZV-A nrPDB Length = 569 Score = 35.0 bits (79), Expect = 0.078, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 105 YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA 164 + V+E + G L D +++ +E + K L+ ++ +G +H D++P N+++DA Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 165 NGALKVSDFG 174 ++ DFG Sbjct: 375 RQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 105 YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA 164 + V+E + G L D +++ +E + K L+ ++ +G +H D++P N+++DA Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 165 NGALKVSDFG 174 ++ DFG Sbjct: 375 RQHARLIDFG 384 >4CI6-B nrPDB Length = 643 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 60/138 (43%), Gaps = 29/138 (21%) Query: 69 KNKMIAQIKREISTMKLI--------------KHPNV--IRMFEVMASKTKIYFVL--EF 110 K +++A+I+R I+ L KHPN+ + V+ + Y+ L + Sbjct: 68 KQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDE 127 Query: 111 VTGGELFDKISS------NGRLKEDE----ARKYFQQLINAVDYCHSRGVYHRDLKPENL 160 V G D + S G++ + + +L++ ++ G+ H D+KP N+ Sbjct: 128 VDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNV 187 Query: 161 LLD-ANGALKVSDFGLSA 177 + D A+G V D GL + Sbjct: 188 VFDRASGEPVVIDLGLHS 205 >2W1Z-A nrPDB Length = 368 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 44/210 (20%), Positives = 79/210 (37%), Gaps = 37/210 (17%) Query: 58 AIKVIDKEKVLKNKMIAQIK---------REISTMKLIKHPNVIRMFEVMASKTKIYFVL 108 AIK + E+VL+ +++ IK R I + L+K P +M V + ++ + Sbjct: 101 AIKQL-SEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLS 159 Query: 109 EF-----------VTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKP 157 F + G L S++ L + QLI G+ H D + Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 158 ENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA---- 213 N+LLD G + ++ F + + DG + + PE + + Sbjct: 220 RNILLDQRGGVFLTGF------EHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTL 273 Query: 214 -----DLWSCGVILFVLMAGYLP-FEDSNL 237 D W+ G+ ++ + LP ED+ L Sbjct: 274 MTFPFDTWTLGLAIYWIWCADLPNTEDAEL 303 >4CYJ-A nrPDB Length = 438 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 33/152 (21%), Positives = 65/152 (42%), Gaps = 25/152 (16%) Query: 48 ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASK----TK 103 A+N NG + A++ ++ ++ K I + ++ K IK+ +++ + EV ++ + Sbjct: 74 AQNSRNGRHYALRRLEGYRLTNEKAILNVMKD---WKKIKNASIVTIHEVFTTREFGDSS 130 Query: 104 IYFVLEF-----VTGGELFDKISSN-----GRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + F +F F I N + E+ Y Q+ NA+ HS + R Sbjct: 131 LIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAAR 190 Query: 154 DLKPENLL--------LDANGALKVSDFGLSA 177 L+P ++ L A L V FG+++ Sbjct: 191 CLEPSKIILTDINRIRLSACAILDVVQFGMNS 222 >4WOV-A nrPDB Length = 317 Score = 32.3 bits (72), Expect = 0.43, Method: Compositional matrix adjust. Identities = 53/240 (22%), Positives = 92/240 (38%), Gaps = 26/240 (10%) Query: 57 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL 116 V +KV+D + + S M + H ++ + V + V E+V G L Sbjct: 87 VVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 143 Query: 117 FDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYHRDLKPENLLLDANGA------- 167 D R A K QQL +A+ Y ++ + H ++ N+LL G Sbjct: 144 -DVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPF 202 Query: 168 LKVSD--FGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILF- 223 +K+SD GL AL ++ R + + ++APE + + A D W G L Sbjct: 203 IKLSDPGVGLGALSREERVERI--------PWLAPECLPGGANSLSTAMDKWGFGATLLE 254 Query: 224 VLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + G P + S S + ++ + P L + L P R +F ++ + Sbjct: 255 ICFDGEAPLQ-SRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 313 >5C01-A nrPDB Length = 342 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 94/244 (38%), Gaps = 34/244 (13%) Query: 57 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL 116 V +KV+D + + S M + H ++ + V + V E+V G L Sbjct: 110 VVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL 166 Query: 117 FDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYHRDLKPENLLLDANGA------- 167 D R A K QQL +A+ Y ++ + H ++ N+LL G Sbjct: 167 -DVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPF 225 Query: 168 LKVSD--FGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILF- 223 +K+SD GL AL ++ R + + ++APE + + A D W G L Sbjct: 226 IKLSDPGVGLGALSREERVERI--------PWLAPECLPGGANSLSTAMDKWGFGATLLE 277 Query: 224 VLMAGYLPFED---SNLTSLYKKIFK-AEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 + G P + S Y++ + E +CP L + L P R +F Sbjct: 278 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCP-----QLATLTSQCLTYEPTQRPSFRT 332 Query: 280 VIEN 283 ++ + Sbjct: 333 ILRD 336 >6BHC-A nrPDB Length = 438 Score = 31.6 bits (70), Expect = 0.72, Method: Compositional matrix adjust. Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 6/85 (7%) Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW--- 254 +APE+I Y K D + G++++ ++ PF D N ++ +A+ P+ Sbjct: 264 LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF-DENPELKEREYTRADLPRIPFRSP 320 Query: 255 FSASAKKLIKRILDPNPATRITFAE 279 +S ++L +L+PNP+ RI ++ Sbjct: 321 YSRGLQQLASCLLNPNPSERILISD 345 >5VE6-A nrPDB Length = 492 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 74/198 (37%), Gaps = 60/198 (30%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALK--------------------------- 169 QL N +++ G+ HRDL ENLLL + L+ Sbjct: 216 QLCNGLEHLKEHGIIHRDLCLENLLL-VHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPA 274 Query: 170 ---VSDFGLSALPQQVREDGLLHTTC-----------GTPNY--------VAPEVINNKG 207 +S A P+ RE L GTPN +APE+++ Sbjct: 275 GGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQ 334 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP-----WFSASAKKL 262 Y K D + G++++ L+ PFE L ++ ++ E PP +S ++L Sbjct: 335 YR--KFDEFQTGILIYELLHQPNPFEVR--AQLRERDYRQE-DLPPLPALSLYSPGLQQL 389 Query: 263 IKRILDPNPATRITFAEV 280 +L+ +P RI E Sbjct: 390 AHLLLEADPIKRIRIGEA 407 >3Q60-A nrPDB Length = 371 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 42/98 (42%), Gaps = 8/98 (8%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 QLI S+G+ H P+NL + +G L + D +SAL + G P Sbjct: 202 QLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSAL----WKVGTRGPASSVPV 255 Query: 197 YVAP-EVINNKGYDGAKA-DLWSCGVILFVLMAGYLPF 232 AP E +N A + W G+ ++ + +LPF Sbjct: 256 TYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF 293 >6GOL-A nrPDB Length = 72 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L + DSN+ +LY+K+ Sbjct: 23 NKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKV 64 >5DMZ-A nrPDB Length = 365 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 38/219 (17%), Positives = 85/219 (38%), Gaps = 33/219 (15%) Query: 35 RTLGEGTFAKVKFA-----RNVENGDNVAIKVIDK----EKVLKNKMIAQIKREISTMKL 85 LGEG FA+V A + +N +KV E + +++ ++K + M Sbjct: 71 HLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHM-- 128 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-----SSNGRLKEDEARKYFQQLIN 140 ++ + + V E + G L + I + + + + +++ Sbjct: 129 -----FMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLY 183 Query: 141 AVDYCHSRGVYHRDLKPENLLL-----------DANGALKVSDFGLSALPQQVREDGLLH 189 ++ H + H D+KP+N +L D + L + D G S + + + Sbjct: 184 MIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFT 243 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 228 C T + E+++NK ++ + D + ++ ++ G Sbjct: 244 AKCETSGFQCVEMLSNKPWN-YQIDYFGVAATVYCMLFG 281 >5UU1-A nrPDB Length = 324 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 55/138 (39%), Gaps = 31/138 (22%) Query: 117 FDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKV--SDF 173 KIS NG K+ + ++++ ++Y H H D+K NLLL +V +D+ Sbjct: 117 LQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 176 Query: 174 GLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA----------------KADLWS 217 GLS + C N+ + KG++G ++D+ Sbjct: 177 GLS------------YRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEI 224 Query: 218 CGVILFVLMAGYLPFEDS 235 G + + G LP+E + Sbjct: 225 LGYCMLRWLCGKLPWEQN 242 >6EWX-A nrPDB Length = 484 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 13/26 (50%), Positives = 17/26 (65%) Query: 137 QLINAVDYCHSRGVYHRDLKPENLLL 162 QL N +++ G+ HRDL ENLLL Sbjct: 218 QLCNGLEHLKEHGIIHRDLCLENLLL 243 >5UG0-B nrPDB Length = 182 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 81 NKKVDDGFIDIWTYNAELLVLLENERTLDFHDSNVKNLYEKV 122 >5E35-B nrPDB Length = 180 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 3/46 (6%) Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 E +N K DG D+W+ L VLM L F DSN+ +LY+K+ Sbjct: 78 ENLNKKMEDGF-LDVWTYNAELLVLMENERTLDFHDSNVKNLYEKV 122 >5W5U-B nrPDB Length = 176 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 81 NKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKV 122 >6N41-A nrPDB Length = 499 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 410 NKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKV 451 >1Y0Y-A nrPDB Length = 353 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 19/30 (63%) Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGG 114 +I HP ++R E +A K +I + LE + GG Sbjct: 267 VICHPTIVRWLEELAKKHEIPYQLEILLGG 296 >6HJN-B nrPDB Length = 173 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 81 NKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVRNLYEKV 122 >3TFC-A nrPDB Length = 385 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 4/96 (4%) Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA-K 212 DL ENL +N + + L Q+ D LL N V E+ KG G+ + Sbjct: 12 DLGTENLYFQSNAMVNTNLEELRTQVDQLNID-LLELISKRANLVQ-EIGKIKGTQGSLR 69 Query: 213 AD-LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA 247 D L ++ +L A PFEDS + L+K+IFKA Sbjct: 70 FDPLREREMLNTILAANEGPFEDSTVQKLFKEIFKA 105 >6MYA-A nrPDB Length = 499 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 410 NKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKV 451 >4HFU-B nrPDB Length = 174 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 3/46 (6%) Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 E +N K DG D+W+ L VLM L F DSN+ +LY K+ Sbjct: 78 ENLNKKMEDGF-LDVWTYNAELLVLMENERTLDFHDSNVKNLYDKV 122 >6A0Z-A nrPDB Length = 551 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 3/46 (6%) Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 E +N K DG D+W+ L VLM L F DSN+ +LY K+ Sbjct: 409 ENLNKKMEDGF-LDVWTYNAELLVLMENERTLDFHDSNVKNLYDKV 453 >2WR0-A nrPDB Length = 509 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 3/46 (6%) Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 E +N K DG D+W+ L VLM L F DSN+ +LY K+ Sbjct: 418 ENLNKKMEDGF-LDVWTYNAELLVLMENERTLDFHDSNVKNLYDKV 462 >2WR7-A nrPDB Length = 506 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 3/46 (6%) Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 E +N K DG D+W+ L VLM L F DSN+ +LY K+ Sbjct: 418 ENLNKKMEDGF-LDVWTYNAELLVLMENERTLDFHDSNVKNLYDKV 462 >2WRH-I nrPDB Length = 222 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L F DSN+ +LY+K+ Sbjct: 81 NKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVRNLYEKV 122 >4CZY-B nrPDB Length = 429 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 28/133 (21%), Positives = 62/133 (46%), Gaps = 18/133 (13%) Query: 48 ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASK----TK 103 A+N +NG + A++ I+ ++ K I + +E K I + N++ + E ++ + Sbjct: 63 AQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGDSS 119 Query: 104 IYFVLEFVTGGE-LFD----------KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 + FV +F E L+D ++ + ++ E+ Y Q+ NA+ H+ + Sbjct: 120 LIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAA 179 Query: 153 RDLKPENLLLDAN 165 R L+ ++ + N Sbjct: 180 RCLELSKIIWENN 192 >4LVH-A nrPDB Length = 518 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 205 NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 NK D D+W+ L VL+ L + DSN+ +LY+K+ Sbjct: 417 NKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKV 458 >4F3Z-B nrPDB Length = 179 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 3/52 (5%) Query: 196 NYVAPEVIN-NKGYDGAKADLWSCGVILFVLMAG--YLPFEDSNLTSLYKKI 244 N++ + N NK D D+W+ L +L+ L + DSN+ +LY+K+ Sbjct: 71 NHLEKRIENLNKKVDDGFLDIWTYNAELLILLENERTLDYHDSNVKNLYEKV 122 >3JB8-A nrPDB Length = 185 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 28/64 (43%) Query: 315 SKNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIV 374 S + ++ R + P AF I Q LGS +KQM R K+SA + V Sbjct: 103 SATIALKNRGPSIVMPQNRTAFRCIQAGQFAALGSAADKQMYSPGRFIVAIPKASATQAV 162 Query: 375 TKIE 378 +I+ Sbjct: 163 GQIK 166 >2ROG-A nrPDB Length = 66 Score = 28.1 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 22/41 (53%) Query: 291 KAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPV 331 K P E +VSL+ +A+ + + + K LV EEG K V Sbjct: 24 KVPGVEKVEVSLEKGEALVEGTADPKALVQAVEEEGYKAEV 64 >6ICZ-o nrPDB Length = 255 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 1/34 (2%) Query: 280 VIENEWFKKGYKAPKFENADVSLDDVDAI-FDDS 312 V + E +GYK P EN +LD DAI F D+ Sbjct: 19 VRDRELDLRGYKIPVIENLGATLDQFDAIDFSDN 52 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4CZT-A nrPDB 707 0.0 4D28-A nrPDB 579 e-166 4CFF-A nrPDB 342 2e-94 5EZV-A nrPDB 339 2e-93 4REW-A nrPDB 338 3e-93 4CFH-A nrPDB 336 9e-93 4RED-A nrPDB 335 2e-92 2YZA-A nrPDB 333 1e-91 4D2V-A nrPDB 332 2e-91 4CQG-A nrPDB 329 1e-90 5KZ7-A nrPDB 329 2e-90 5ES1-A nrPDB 328 3e-90 2QNJ-A nrPDB 327 6e-90 3MN3-A nrPDB 326 1e-89 3H4J-B nrPDB 325 2e-89 4YNZ-A nrPDB 319 1e-87 5YKS-A nrPDB 314 4e-86 5JN2-A nrPDB 313 1e-85 4MVF-A nrPDB 311 4e-85 2HAK-A nrPDB 308 3e-84 3MA6-A nrPDB 308 5e-84 3DXN-A nrPDB 307 7e-84 3HZT-A nrPDB 307 7e-84 6C9D-A nrPDB 307 9e-84 3DFA-A nrPDB 306 1e-83 3NCG-A nrPDB 305 2e-83 5WAX-A nrPDB 303 2e-82 3D2K-A nrPDB 302 2e-82 4UZD-A nrPDB 302 3e-82 5IG1-A nrPDB 300 7e-82 2VN9-A nrPDB 300 9e-82 1FOT-A nrPDB 300 9e-82 3LIJ-A nrPDB 299 2e-81 3ZUT-A nrPDB 297 5e-81 4I6B-A nrPDB 297 8e-81 4YZB-A nrPDB 297 9e-81 2VZ6-A nrPDB 296 2e-80 4B6L-A nrPDB 296 2e-80 5FG8-A nrPDB 296 2e-80 5U6Y-A nrPDB 295 3e-80 2V7O-A nrPDB 294 7e-80 4FG9-A nrPDB 294 8e-80 3BHH-A nrPDB 293 8e-80 4JXF-A nrPDB 293 9e-80 3TXO-A nrPDB 293 1e-79 2BDW-A nrPDB 293 1e-79 3DB8-A nrPDB 292 2e-79 3KK8-A nrPDB 292 2e-79 2JDO-A nrPDB 292 2e-79 2JC6-A nrPDB 292 3e-79 4L42-A nrPDB 292 3e-79 3UC3-A nrPDB 291 5e-79 3MV5-A nrPDB 291 6e-79 3UDB-A nrPDB 290 8e-79 5KCV-A nrPDB 290 1e-78 3Q5I-A nrPDB 289 2e-78 4RLP-A nrPDB 289 2e-78 2JAM-A nrPDB 289 3e-78 4RGJ-A nrPDB 288 3e-78 3SOA-A nrPDB 288 3e-78 5D9K-A nrPDB 287 6e-78 5XZW-A nrPDB 287 8e-78 3HDN-A nrPDB 287 1e-77 4RA4-A nrPDB 286 1e-77 5X3F-B nrPDB 285 2e-77 4WB7-A nrPDB 285 3e-77 2Z7Q-A nrPDB 285 3e-77 3F3Z-A nrPDB 284 4e-77 2OU7-A nrPDB 284 4e-77 5N23-A nrPDB 284 8e-77 4B8L-A nrPDB 283 1e-76 6FDY-U nrPDB 282 2e-76 5F9E-A nrPDB 282 3e-76 4J52-A nrPDB 281 4e-76 4NIF-A nrPDB 281 6e-76 6CMJ-A nrPDB 281 6e-76 5JZN-A nrPDB 281 7e-76 4PDS-A nrPDB 280 1e-75 2YCR-A nrPDB 279 1e-75 3TAC-A nrPDB 279 2e-75 3COM-A nrPDB 279 2e-75 4CSV-A nrPDB 279 2e-75 3ORZ-A nrPDB 279 2e-75 4JG6-A nrPDB 278 3e-75 2BPM-A nrPDB 278 3e-75 2J90-A nrPDB 277 5e-75 2W4O-A nrPDB 277 7e-75 3I6U-A nrPDB 277 1e-74 4AF3-A nrPDB 275 2e-74 5YV8-A nrPDB 275 3e-74 6E9W-A nrPDB 274 6e-74 4LG4-A nrPDB 273 1e-73 1PHK-A nrPDB 272 3e-73 3PFQ-A nrPDB 271 3e-73 6ED6-A nrPDB 271 4e-73 1CM8-A nrPDB 271 5e-73 2Y7J-A nrPDB 271 5e-73 4C0T-A nrPDB 271 6e-73 5DYK-A nrPDB 270 9e-73 6AO5-A nrPDB 270 1e-72 3GUB-A nrPDB 270 1e-72 2I0E-A nrPDB 269 1e-72 5FET-A nrPDB 269 1e-72 2BRG-A nrPDB 269 2e-72 6FD3-A nrPDB 269 2e-72 1VZO-A nrPDB 268 3e-72 3DAK-A nrPDB 268 3e-72 4QMW-A nrPDB 268 4e-72 4XEY-B nrPDB 268 5e-72 3IS5-A nrPDB 268 5e-72 2FO0-A nrPDB 267 5e-72 2YAB-A nrPDB 267 6e-72 5J5T-A nrPDB 267 9e-72 4AGU-A nrPDB 266 1e-71 5LOH-A nrPDB 266 2e-71 3NIZ-A nrPDB 266 2e-71 2WQN-A nrPDB 266 2e-71 2XIK-A nrPDB 265 3e-71 4MYG-A nrPDB 264 7e-71 4WNO-A nrPDB 263 1e-70 2A27-A nrPDB 263 1e-70 1ZWS-A nrPDB 262 2e-70 4IC8-A nrPDB 262 2e-70 3A8W-A nrPDB 262 2e-70 3Q53-A nrPDB 262 3e-70 3TKU-A nrPDB 262 3e-70 4ZSG-A nrPDB 261 4e-70 4AW2-A nrPDB 261 4e-70 4FZF-B nrPDB 261 5e-70 4AU8-A nrPDB 261 5e-70 3OHT-A nrPDB 261 5e-70 2UV2-A nrPDB 261 5e-70 3UTO-A nrPDB 261 6e-70 5DBX-A nrPDB 261 7e-70 4APC-A nrPDB 260 8e-70 3KN6-A nrPDB 260 8e-70 4BBM-A nrPDB 260 1e-69 6BDL-A nrPDB 259 2e-69 6NPU-A nrPDB 259 2e-69 5Z33-A nrPDB 259 2e-69 4KRC-A nrPDB 259 2e-69 4EWQ-A nrPDB 259 2e-69 1KOA-A nrPDB 259 3e-69 2F57-A nrPDB 257 6e-69 4KS7-A nrPDB 257 6e-69 2XYN-A nrPDB 257 8e-69 4FIE-A nrPDB 256 1e-68 4JDH-A nrPDB 256 1e-68 2Q0N-A nrPDB 256 1e-68 6DTL-A nrPDB 256 1e-68 6GU6-A nrPDB 256 1e-68 5D7A-A nrPDB 256 1e-68 1JPA-A nrPDB 256 2e-68 4XBR-A nrPDB 256 2e-68 6QAU-A nrPDB 256 2e-68 4XCU-A nrPDB 255 3e-68 5H2U-A nrPDB 255 3e-68 6HXF-B nrPDB 255 3e-68 5AWM-A nrPDB 255 3e-68 4FR4-A nrPDB 255 4e-68 2HW6-A nrPDB 253 1e-67 1V0B-A nrPDB 253 1e-67 5MJB-A nrPDB 253 1e-67 2X4F-A nrPDB 253 1e-67 4EBW-A nrPDB 253 1e-67 2WTK-C nrPDB 253 1e-67 1NY3-A nrPDB 253 1e-67 2OZA-A nrPDB 252 2e-67 3KA0-A nrPDB 252 2e-67 6CCF-A nrPDB 252 2e-67 4E93-A nrPDB 252 2e-67 3PPZ-A nrPDB 252 2e-67 4U41-A nrPDB 252 3e-67 3TT0-A nrPDB 251 4e-67 3E7O-A nrPDB 251 5e-67 6BXI-A nrPDB 251 6e-67 3DKO-A nrPDB 251 6e-67 2Y6O-A nrPDB 251 6e-67 1KOB-A nrPDB 251 6e-67 6E2O-A nrPDB 251 7e-67 4QNY-A nrPDB 251 7e-67 3GC9-A nrPDB 250 9e-67 3HKO-A nrPDB 250 9e-67 2F9G-A nrPDB 250 9e-67 5A46-A nrPDB 250 1e-66 3GQL-A nrPDB 250 1e-66 1JNK-A nrPDB 250 1e-66 5TUR-A nrPDB 250 1e-66 2J0K-A nrPDB 249 2e-66 4QTB-A nrPDB 249 2e-66 3V5Q-A nrPDB 249 2e-66 3BGP-A nrPDB 249 2e-66 3FXW-A nrPDB 249 2e-66 2VD5-A nrPDB 249 2e-66 5NGU-A nrPDB 249 2e-66 3ZDU-A nrPDB 249 2e-66 4NST-A nrPDB 249 3e-66 2VWV-A nrPDB 249 3e-66 2R2P-A nrPDB 248 4e-66 2H8H-A nrPDB 248 4e-66 5L6P-A nrPDB 248 4e-66 4UY9-A nrPDB 248 4e-66 4P5Q-A nrPDB 248 5e-66 5EFQ-A nrPDB 247 5e-66 6GQK-A nrPDB 247 6e-66 4AT3-A nrPDB 247 7e-66 6F3F-A nrPDB 247 8e-66 3NYO-A nrPDB 247 9e-66 1UA2-A nrPDB 246 1e-65 6CQF-A nrPDB 246 2e-65 4X7Q-B nrPDB 246 2e-65 2XS0-A nrPDB 245 2e-65 5SYS-A nrPDB 245 2e-65 4RC3-A nrPDB 245 2e-65 1K9A-A nrPDB 245 3e-65 3DTC-A nrPDB 245 3e-65 5VO2-A nrPDB 244 5e-65 4UYA-A nrPDB 244 5e-65 4TNB-A nrPDB 244 7e-65 3KUL-B nrPDB 244 8e-65 2PSQ-A nrPDB 244 8e-65 3OZ6-A nrPDB 244 8e-65 1U5R-A nrPDB 244 8e-65 4H1J-A nrPDB 244 8e-65 2XNP-A nrPDB 244 1e-64 1BYG-A nrPDB 243 1e-64 2DQ7-X nrPDB 243 1e-64 2GCD-A nrPDB 243 1e-64 4OLI-A nrPDB 243 1e-64 4K33-A nrPDB 243 1e-64 4OTD-A nrPDB 242 3e-64 4LQP-A nrPDB 242 3e-64 4XLV-A nrPDB 242 3e-64 3SXS-A nrPDB 242 4e-64 1G3N-A nrPDB 241 4e-64 6CKI-A nrPDB 241 6e-64 5KMM-A nrPDB 240 7e-64 3VN9-A nrPDB 240 7e-64 1FVR-A nrPDB 240 9e-64 4XI2-A nrPDB 240 1e-63 4CRS-A nrPDB 240 1e-63 2OGV-A nrPDB 239 2e-63 5EG3-A nrPDB 239 2e-63 4GS6-A nrPDB 239 2e-63 5UUU-A nrPDB 239 2e-63 3DLS-A nrPDB 239 3e-63 4AN9-A nrPDB 239 3e-63 3BEA-A nrPDB 238 3e-63 3QGY-A nrPDB 238 4e-63 3C51-A nrPDB 238 4e-63 3GC0-A nrPDB 238 4e-63 3PVW-A nrPDB 238 5e-63 5X5O-A nrPDB 237 7e-63 1LUF-A nrPDB 237 9e-63 3IO7-A nrPDB 237 9e-63 6DBM-A nrPDB 237 1e-62 3FI2-A nrPDB 237 1e-62 3KRL-A nrPDB 236 1e-62 4HZS-A nrPDB 236 1e-62 4BGQ-A nrPDB 236 1e-62 3BBT-B nrPDB 236 2e-62 3CJF-A nrPDB 236 2e-62 4PDO-A nrPDB 235 2e-62 6BSD-A nrPDB 235 2e-62 5HI2-A nrPDB 235 3e-62 1U54-B nrPDB 235 3e-62 3MIA-A nrPDB 235 4e-62 3HMP-A nrPDB 235 4e-62 3LM0-A nrPDB 234 5e-62 5HIE-A nrPDB 234 5e-62 5AMN-A nrPDB 234 5e-62 4R7H-A nrPDB 234 5e-62 5G6V-A nrPDB 234 7e-62 6DBN-A nrPDB 234 7e-62 2PL0-A nrPDB 234 7e-62 6FEX-A nrPDB 234 8e-62 3RP9-A nrPDB 234 8e-62 3A4O-X nrPDB 233 1e-61 4E20-A nrPDB 233 1e-61 4YFF-A nrPDB 233 1e-61 4O2Z-A nrPDB 233 1e-61 3G0E-A nrPDB 233 1e-61 2HK5-A nrPDB 233 2e-61 3PP0-A nrPDB 232 2e-61 2ZMD-A nrPDB 231 4e-61 1AD5-A nrPDB 231 5e-61 6GVJ-A nrPDB 231 6e-61 3LZB-A nrPDB 230 7e-61 4XUF-A nrPDB 230 1e-60 5GNK-A nrPDB 229 2e-60 5O2B-A nrPDB 229 2e-60 5FM2-A nrPDB 229 2e-60 6E4F-A nrPDB 229 2e-60 2W96-B nrPDB 229 2e-60 5GRN-A nrPDB 229 2e-60 5X02-A nrPDB 229 2e-60 4Y93-A nrPDB 229 3e-60 5U6B-A nrPDB 228 4e-60 5O2C-A nrPDB 228 4e-60 5HLW-A nrPDB 228 6e-60 2W1I-A nrPDB 227 6e-60 3OMV-A nrPDB 227 7e-60 3ORP-A nrPDB 227 1e-59 2I6L-A nrPDB 226 1e-59 4YHJ-A nrPDB 226 1e-59 4E7W-A nrPDB 226 2e-59 4PWN-A nrPDB 226 2e-59 5AP3-A nrPDB 225 3e-59 3C1X-A nrPDB 225 4e-59 3QUP-A nrPDB 224 6e-59 4LRM-A nrPDB 224 7e-59 4EQM-A nrPDB 224 8e-59 1ZXE-A nrPDB 224 9e-59 3FME-A nrPDB 223 1e-58 5AIR-A nrPDB 223 2e-58 1TKI-A nrPDB 223 2e-58 4PL5-B nrPDB 222 2e-58 2OZO-A nrPDB 222 2e-58 6HV0-A nrPDB 222 3e-58 1U59-A nrPDB 222 3e-58 3I81-A nrPDB 222 3e-58 3M42-A nrPDB 222 4e-58 3PLS-A nrPDB 221 5e-58 5KKR-C nrPDB 221 6e-58 5HVK-A nrPDB 221 7e-58 5WNO-A nrPDB 220 1e-57 5Y86-A nrPDB 220 1e-57 3PG1-A nrPDB 220 1e-57 3EQC-A nrPDB 219 2e-57 3ZBF-A nrPDB 219 3e-57 4FL3-A nrPDB 219 3e-57 4HVI-A nrPDB 218 3e-57 5O0Y-A nrPDB 218 4e-57 6FER-A nrPDB 218 4e-57 3E3P-A nrPDB 216 2e-56 2EHB-D nrPDB 216 2e-56 5C26-A nrPDB 216 2e-56 3N9X-A nrPDB 216 2e-56 6B2Q-A nrPDB 216 2e-56 5U6C-A nrPDB 215 3e-56 4OW8-A nrPDB 214 5e-56 4X3F-A nrPDB 214 6e-56 6DC0-A nrPDB 214 7e-56 1S9I-A nrPDB 214 7e-56 5CEK-A nrPDB 214 8e-56 3AOX-A nrPDB 214 1e-55 4Y83-A nrPDB 213 2e-55 4NEU-A nrPDB 212 2e-55 4IDT-A nrPDB 212 2e-55 3NIE-A nrPDB 212 3e-55 5UIU-A nrPDB 211 4e-55 5X8I-B nrPDB 210 8e-55 4C59-A nrPDB 210 8e-55 4M7I-A nrPDB 210 9e-55 5B2L-A nrPDB 210 9e-55 5ZTN-A nrPDB 210 1e-54 4TPT-A nrPDB 209 2e-54 3ALO-A nrPDB 209 2e-54 3ZZW-A nrPDB 209 2e-54 5WNL-A nrPDB 208 5e-54 3EB0-A nrPDB 208 6e-54 3LMG-A nrPDB 205 3e-53 3QA8-A nrPDB 205 5e-53 6FYV-A nrPDB 204 6e-53 5TOS-A nrPDB 204 8e-53 4F0G-A nrPDB 204 1e-52 4KIK-B nrPDB 202 3e-52 4G3E-A nrPDB 200 1e-51 5TQX-A nrPDB 199 3e-51 3Q4U-A nrPDB 198 6e-51 2WTK-B nrPDB 196 1e-50 2A1A-B nrPDB 196 2e-50 5VD3-A nrPDB 196 2e-50 2H34-A nrPDB 195 3e-50 6J5U-C nrPDB 195 3e-50 6O6Q-A nrPDB 195 4e-50 5LPZ-A nrPDB 195 5e-50 6CTH-A nrPDB 194 9e-50 5LPV-A nrPDB 193 1e-49 3MY0-A nrPDB 193 1e-49 5TE0-A nrPDB 193 1e-49 5AR8-A nrPDB 193 2e-49 3RAW-A nrPDB 192 3e-49 3UIU-A nrPDB 192 3e-49 5UNP-A nrPDB 191 6e-49 2Y4I-B nrPDB 190 9e-49 2WO6-A nrPDB 190 1e-48 5IKW-A nrPDB 189 2e-48 2BUJ-A nrPDB 189 2e-48 2RIO-A nrPDB 187 7e-48 4JLC-A nrPDB 187 7e-48 3MDY-A nrPDB 187 1e-47 4EUU-A nrPDB 187 1e-47 4EUT-A nrPDB 185 2e-47 2PMN-X nrPDB 184 7e-47 2PVN-A nrPDB 183 1e-46 6O8B-A nrPDB 183 1e-46 6NT9-A nrPDB 183 1e-46 5VC6-A nrPDB 182 3e-46 1PY5-A nrPDB 182 4e-46 5L2Q-C nrPDB 181 5e-46 4MD7-E nrPDB 180 8e-46 3UIM-A nrPDB 180 1e-45 6HMD-A nrPDB 180 1e-45 4CRL-A nrPDB 179 3e-45 5XVU-A nrPDB 178 4e-45 3SOC-A nrPDB 178 4e-45 6EII-A nrPDB 178 6e-45 4M66-A nrPDB 178 6e-45 4M69-B nrPDB 175 3e-44 4BTF-A nrPDB 175 3e-44 5XD6-A nrPDB 175 5e-44 5E8V-A nrPDB 175 5e-44 2QKW-B nrPDB 174 7e-44 4MWI-A nrPDB 173 1e-43 4NT4-A nrPDB 173 2e-43 2QLU-A nrPDB 173 2e-43 2JD5-A nrPDB 173 2e-43 3REP-A nrPDB 172 2e-43 3VHK-A nrPDB 171 6e-43 5VDK-A nrPDB 170 1e-42 4IAN-A nrPDB 170 1e-42 3QD2-B nrPDB 169 2e-42 3LLT-A nrPDB 167 7e-42 6BFN-A nrPDB 167 1e-41 2CMW-A nrPDB 166 2e-41 2CHL-A nrPDB 165 4e-41 3HNG-A nrPDB 164 7e-41 4LFI-A nrPDB 163 2e-40 2C47-A nrPDB 163 2e-40 4WUA-A nrPDB 162 2e-40 3G2F-A nrPDB 162 5e-40 5X18-A nrPDB 160 1e-39 2X7G-A nrPDB 160 2e-39 4NFN-A nrPDB 159 3e-39 3SV0-A nrPDB 158 4e-39 5FQD-C nrPDB 158 5e-39 4L00-A nrPDB 158 5e-39 5USZ-A nrPDB 158 5e-39 4BTK-A nrPDB 158 6e-39 4F9B-A nrPDB 155 4e-38 5X1R-A nrPDB 155 4e-38 4TN6-A nrPDB 154 6e-38 4RT7-A nrPDB 152 3e-37 5M07-A nrPDB 148 4e-36 1CSN-A nrPDB 144 1e-34 2PZI-A nrPDB 141 8e-34 4Y12-A nrPDB 140 1e-33 4XHH-A nrPDB 137 1e-32 4JRN-A nrPDB 136 1e-32 4XHL-A nrPDB 135 3e-32 2ZFD-B nrPDB 124 1e-28 6EQI-C nrPDB 123 2e-28 5OAT-A nrPDB 122 3e-28 6J6I-B nrPDB 116 2e-26 4OAU-C nrPDB 99 4e-21 4O1O-A nrPDB 98 6e-21 5CLR-A nrPDB 98 6e-21 Sequences not found previously or not previously below threshold: 5J0A-A nrPDB 148 5e-36 5C01-A nrPDB 130 1e-30 4WOV-A nrPDB 130 1e-30 4L68-A nrPDB 116 2e-26 4I94-A nrPDB 113 1e-25 5UV4-A nrPDB 113 2e-25 5UU1-A nrPDB 99 5e-21 2RSV-A nrPDB 94 2e-19 2LAV-A nrPDB 93 2e-19 6EAS-A nrPDB 88 6e-18 5DMZ-A nrPDB 86 4e-17 4IX6-A nrPDB 81 1e-15 6G4J-A nrPDB 72 5e-13 5GZ9-A nrPDB 70 2e-12 6M7Z-A nrPDB 70 3e-12 6BHC-A nrPDB 69 4e-12 5GZA-A nrPDB 65 6e-11 6EWX-A nrPDB 65 7e-11 4CI6-B nrPDB 64 2e-10 3BYV-A nrPDB 63 2e-10 3DZO-A nrPDB 61 8e-10 2JII-A nrPDB 61 1e-09 2W1Z-A nrPDB 58 9e-09 4CYJ-A nrPDB 57 2e-08 4AZW-A nrPDB 56 3e-08 4AZV-A nrPDB 56 4e-08 4CZY-B nrPDB 55 8e-08 3ENH-A nrPDB 55 1e-07 6G38-A nrPDB 51 1e-06 4WWA-A nrPDB 50 3e-06 5VE6-A nrPDB 49 5e-06 4BWP-A nrPDB 47 2e-05 3Q60-A nrPDB 44 1e-04 4OTP-A nrPDB 43 2e-04 1TQM-A nrPDB 43 3e-04 6G5I-z nrPDB 43 3e-04 1ZP9-A nrPDB 40 0.002 5YK0-A nrPDB 39 0.005 4BVU-A nrPDB 38 0.006 6FAI-l nrPDB 34 0.13 6G18-v nrPDB 34 0.16 6FDN-A nrPDB 34 0.17 >4CZT-A nrPDB Length = 464 Score = 707 bits (1824), Expect = 0.0, Method: Composition-based stats. Identities = 459/460 (99%), Positives = 459/460 (99%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST Sbjct: 5 SGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 64 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV Sbjct: 65 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 244 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVER 322 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVER Sbjct: 245 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVER 304 Query: 323 REEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAA 382 REEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAA Sbjct: 305 REEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAA 364 Query: 383 PMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKN 442 PMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKN Sbjct: 365 PMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKN 424 Query: 443 LTTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST 482 LTTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST Sbjct: 425 LTTGLKDIVWKTIDEEKEEGTDGGGTNGAMANRTIAKQST 464 >4D28-A nrPDB Length = 446 Score = 579 bits (1493), Expect = e-166, Method: Composition-based stats. Identities = 264/432 (61%), Positives = 339/432 (78%), Gaps = 7/432 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 RVGKYE+GRT+GEGTFAKVKFARN + GDNVAIK++ K +LKN+M+ QIKREIS MK++ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 +HPN++R++EV+ASK+KIY VLEFVTGGELFD+I GRLKEDE+RKYFQQL++AV +CH Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 S+GVYHRDLKPENLLLD NG LKVSDFGLSALPQ+ E LL+ TCGTPNYVAPEV++ + Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE--LLNDTCGTPNYVAPEVLSGQ 184 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 GYDG+ AD+WSCGVILFV++AGYLPF +++L LY+KI AEF CPPWFSA K LI RI Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRI 244 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKF-ENADVSLDDVDAIFDD-SGESKNLVVERRE 324 LDPNP TRI + ++ WF+K Y + E +V+LDD+ A+FD G VER + Sbjct: 245 LDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAENVERND 304 Query: 325 EGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPM 384 EG P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A M Sbjct: 305 EG---PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSM 361 Query: 385 GFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLT 444 GF T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L Sbjct: 362 GFKSHTRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLC 421 Query: 445 TGLKDIVWKTID 456 + L++I+W+ + Sbjct: 422 SKLENIIWRATE 433 >4CFF-A nrPDB Length = 571 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 133/370 (35%), Positives = 218/370 (58%), Gaps = 10/370 (2%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI Sbjct: 27 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 86 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++AV Sbjct: 87 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 146 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 DYCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APEV Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEV 203 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 204 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 263 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVER 322 + +L +P R T ++ E+EWFK+ P + + D + I D++ + E Sbjct: 264 LMHMLQVDPLKRATIKDIREHEWFKQ--DLPSYLFPEDPSYDANVIDDEAVKEVCEKFEC 321 Query: 323 RE-EGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAA 381 E E + + + + + ++ + L + + + + + + + S + A Sbjct: 322 TESEVMNSLYSGDPQDQLAVAYHL----IIDNRRIMNQASEFYLASSPPSGSFMDDSAMH 377 Query: 382 APMGFDVKTN 391 P G Sbjct: 378 IPPGLKPHPE 387 >5EZV-A nrPDB Length = 560 Score = 339 bits (870), Expect = 2e-93, Method: Composition-based stats. Identities = 126/289 (43%), Positives = 195/289 (67%), Gaps = 6/289 (2%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI Sbjct: 22 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 81 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++AV Sbjct: 82 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 141 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 DYCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APEV Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEV 198 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 199 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 258 Query: 263 IKRILDPNPATRITFAEVIENEWFKK---GYKAPKFENADVSLDDVDAI 308 + +L +P R T ++ E+EWFK+ Y P+ + D ++ D +A+ Sbjct: 259 LMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 307 >4REW-A nrPDB Length = 540 Score = 338 bits (867), Expect = 3e-93, Method: Composition-based stats. Identities = 122/288 (42%), Positives = 193/288 (67%), Gaps = 6/288 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI + Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ VD Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 YCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APEVI Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEVI 177 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L+ Sbjct: 178 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL 237 Query: 264 KRILDPNPATRITFAEVIENEWFKKG---YKAPKFENADVSLDDVDAI 308 K +L +P R + ++ E+EWFK+ Y P+ + ++ D +A+ Sbjct: 238 KHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL 285 >4CFH-A nrPDB Length = 493 Score = 336 bits (863), Expect = 9e-93, Method: Composition-based stats. Identities = 124/289 (42%), Positives = 194/289 (67%), Gaps = 6/289 (2%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 GR ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI Sbjct: 27 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 86 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ V Sbjct: 87 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 146 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 DYCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APEV Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEV 203 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I+ + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L Sbjct: 204 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISL 263 Query: 263 IKRILDPNPATRITFAEVIENEWFKKG---YKAPKFENADVSLDDVDAI 308 +K +L +P R T ++ E+EWFK+ Y P+ + ++ D +A+ Sbjct: 264 LKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL 312 >4RED-A nrPDB Length = 351 Score = 335 bits (860), Expect = 2e-92, Method: Composition-based stats. Identities = 122/288 (42%), Positives = 193/288 (67%), Gaps = 6/288 (2%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G ++G Y LG TLG GTF KVK ++ G VA+K+++++K+ ++ +I+REI + Sbjct: 9 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNL 68 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL +HP++I++++V+++ + I+ V+E+V+GGELFD I NGRL E E+R+ FQQ+++ VD Sbjct: 69 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 YCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APEVI Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEVI 185 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + + Y G + D+WS GVIL+ L+ G LPF+D ++ +L+KKI F P + + S L+ Sbjct: 186 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL 245 Query: 264 KRILDPNPATRITFAEVIENEWFKKG---YKAPKFENADVSLDDVDAI 308 K +L +P R + ++ E+EWFK+ Y P+ + ++ D +A+ Sbjct: 246 KHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEAL 293 >2YZA-A nrPDB Length = 276 Score = 333 bits (853), Expect = 1e-91, Method: Composition-based stats. Identities = 123/278 (44%), Positives = 187/278 (67%), Gaps = 3/278 (1%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 GS GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKR Sbjct: 1 GSKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 60 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 EI +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+ Sbjct: 61 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 120 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++AVDYCH V HRDLKPEN+LLDA+ K++DFGLS + + L +CG+PNY Sbjct: 121 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRDSCGSPNYA 177 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS 258 APEVI+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S Sbjct: 178 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 237 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFE 296 L+ +L +P R T ++ E+EWFK+ + F Sbjct: 238 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP 275 >4D2V-A nrPDB Length = 356 Score = 332 bits (852), Expect = 2e-91, Method: Composition-based stats. Identities = 123/306 (40%), Positives = 185/306 (60%), Gaps = 8/306 (2%) Query: 16 TPSGSSSGGRTRVGKY-ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 P GS + KY EL T+G G FAKVK A ++ G+ VAIK++DK + + + Sbjct: 15 VPRGSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD--LP 72 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 +IK EI +K ++H ++ +++ V+ + KI+ VLE+ GGELFD I S RL E+E R Sbjct: 73 RIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVV 132 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 F+Q+++AV Y HS+G HRDLKPENLL D LK+ DFGL A P + +D L CG Sbjct: 133 FRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKP-KGNKDYHLQACCGA 191 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW 254 Y APE+I K Y G++AD+WS G++L+VLM G+LPF+D +L KI + ++ P W Sbjct: 192 LAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKW 251 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP---KFENADVSLDDVDAIFDD 311 S S+ L++++L +P RI+ ++ + W + Y P + +N + LDD D + + Sbjct: 252 LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDD-DCVTEL 310 Query: 312 SGESKN 317 S +N Sbjct: 311 SVHHRN 316 >4CQG-A nrPDB Length = 331 Score = 329 bits (845), Expect = 1e-90, Method: Composition-based stats. Identities = 121/290 (41%), Positives = 183/290 (63%), Gaps = 5/290 (1%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YEL T+G G FAKVK A +V G+ VAIK++DK + + + ++K EI +K ++H + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD--LPRVKTEIDALKSLRHQH 68 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 + +++ V+ +K KI+ VLE+ GGELFD I S RL E+E R F+Q+++AV Y HS+G Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGY 128 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRDLKPENLL D N LK+ DFGL A P + +D L CG+ Y APE+I K Y G Sbjct: 129 AHRDLKPENLLFDENHKLKLIDFGLCAKP-KGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPN 270 ++AD+WS G++L+VLM G+LPF+D N+ +LYKKI + ++ P W S S+ L++++L + Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVD 247 Query: 271 PATRITFAEVIENEWFKKGYKAPKFENADVSLD--DVDAIFDDSGESKNL 318 P RI+ ++ + W + Y P + L D D + + S ++ Sbjct: 248 PKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRSS 297 >5KZ7-A nrPDB Length = 346 Score = 329 bits (844), Expect = 2e-90, Method: Composition-based stats. Identities = 112/287 (39%), Positives = 187/287 (65%), Gaps = 4/287 (1%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S +S+ + +G Y L +T+G+G FAKVK AR++ G VA+K+IDK ++ + + ++ Sbjct: 22 SATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKLF 80 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 RE+ MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q Sbjct: 81 REVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 140 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +++AV YCH + + HRDLK ENLLLDA+ +K++DFG S + L T CG+P Y Sbjct: 141 IVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPY 197 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 APE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 198 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST 257 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDD 304 + L+K+ L NP+ R T +++++ W G++ + + L D Sbjct: 258 DCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPD 304 >5ES1-A nrPDB Length = 328 Score = 328 bits (841), Expect = 3e-90, Method: Composition-based stats. Identities = 115/286 (40%), Positives = 181/286 (63%), Gaps = 4/286 (1%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 S + VG Y L RT+G+G FAKVK AR++ G VAIK+IDK + L + ++ R Sbjct: 5 ASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPSSLQKLFR 63 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E+ MK + HPN++++FEV+ ++ +Y V+E+ + GE+FD + S+GR+KE EAR F+Q+ Sbjct: 64 EVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQI 123 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++AV YCH + + HRDLK ENLLLDA +K++DFG S + L T CG+P Y Sbjct: 124 VSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFS---NEFTLGSKLDTFCGSPPYA 180 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS 258 APE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 181 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTD 240 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDD 304 + +++R L NPA R T ++++++W GY+ + + +D Sbjct: 241 CESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEED 286 >2QNJ-A nrPDB Length = 328 Score = 327 bits (839), Expect = 6e-90, Method: Composition-based stats. Identities = 113/288 (39%), Positives = 183/288 (63%), Gaps = 4/288 (1%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 S + +G Y L +T+G+G FAKVK AR++ G VAIK+IDK + L + ++ R Sbjct: 2 AMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFR 60 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E+ MK++ HPN++++FEV+ ++ +Y ++E+ +GGE+FD + ++GR+KE EAR F+Q+ Sbjct: 61 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 120 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++AV YCH + + HRDLK ENLLLDA+ +K++DFG S + G L T CG+P Y Sbjct: 121 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYA 177 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS 258 APE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 178 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 237 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVD 306 + L+KR L NP R T +++++ W G++ + + D+ Sbjct: 238 CENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDIS 285 >3MN3-A nrPDB Length = 271 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 120/261 (45%), Positives = 184/261 (70%), Gaps = 4/261 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 +G Y++ +TLGEG+F KVK A + G VA+K+I+K+ + K+ M +I+REIS ++L+ Sbjct: 2 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 61 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 +HP++I++++V+ SK +I V+E+ G ELFD I ++ E EAR++FQQ+I+AV+YCH Sbjct: 62 RHPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKPENLLLD + +K++DFGLS + + + L T+CG+PNY APEVI+ K Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVISGK 177 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 266 Y G + D+WSCGVIL+V++ LPF+D ++ L+K I +T P + S A LIKR+ Sbjct: 178 LYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRM 237 Query: 267 LDPNPATRITFAEVIENEWFK 287 L NP RI+ E+++++WFK Sbjct: 238 LIVNPLNRISIHEIMQDDWFK 258 >3H4J-B nrPDB Length = 336 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 120/306 (39%), Positives = 192/306 (62%), Gaps = 18/306 (5%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 + +G Y + TLGEG+F KVK A + + VA+K I ++ + K+ M +++REIS + Sbjct: 4 SKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYL 63 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 KL++HP++I++++V+ + T I V+E+ GGELFD I R+ EDE R++FQQ+I A++ Sbjct: 64 KLLRHPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIICAIE 122 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 YCH + HRDLKPENLLLD N +K++DFGLS + + + L T+CG+PNY APEVI Sbjct: 123 YCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNI---MTDGNFLKTSCGSPNYAAPEVI 179 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 N K Y G + D+WSCG++L+V++ G LPF+D + +L+KK+ + P + S A+ LI Sbjct: 180 NGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLI 239 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDS--GESKNLVVE 321 +R++ +P RIT E+ + WF +V+L D ++ + + +V Sbjct: 240 RRMIVADPMQRITIQEIRRDPWF------------NVNLPDYLRPMEEVQGSYADSRIVS 287 Query: 322 RREEGL 327 + E + Sbjct: 288 KLGEAM 293 >4YNZ-A nrPDB Length = 342 Score = 319 bits (819), Expect = 1e-87, Method: Composition-based stats. Identities = 125/311 (40%), Positives = 192/311 (61%), Gaps = 13/311 (4%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G VG Y L +TLG+G VK + VAIK++++EK L ++ +++REI+ Sbjct: 4 GSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREK-LSESVLMKVEREIAI 62 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +KLI+HP+V+++ +V +K +Y VLE V+GGELFD + GRL EARK+F+Q+I+A+ Sbjct: 63 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 122 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 D+CHS + HRDLKPENLLLD ++++DFG+++L D LL T+CG+P+Y PEV Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQ---VGDSLLETSCGSPHYACPEV 179 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 262 I + YDG KAD+WSCGVILF L+ G LPF+D NL L +K+ + F P + + L Sbjct: 180 IRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSL 239 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN---------ADVSLDDVDAIFDDSG 313 ++ +++ + A R+T + ++ W+ G P+ E + SL+D+D DS Sbjct: 240 LRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSM 299 Query: 314 ESKNLVVERRE 324 S +R + Sbjct: 300 HSLGCFRDRNK 310 >5YKS-A nrPDB Length = 377 Score = 314 bits (806), Expect = 4e-86, Method: Composition-based stats. Identities = 115/299 (38%), Positives = 175/299 (58%), Gaps = 14/299 (4%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 G Y+L +TLG G FA VK AR+V G+ VA+KVIDK K L + +E+ MKL++ Sbjct: 34 AGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTK-LDTLATGHLFQEVRCMKLVQ 92 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCH 146 HPN++R++EV+ ++TK+Y +LE GG++FD I + L ED A+KYF Q+++A+ YCH Sbjct: 93 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 152 Query: 147 SRGVYHRDLKPENL-LLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 V HRDLKPEN+ + G +K++DFG S + + L T+CG+ Y APE++ Sbjct: 153 KLHVVHRDLKPENVVFFEKQGLVKLTDFGFS---NKFQPGKKLTTSCGSLAYSAPEILLG 209 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 YD D+WS GVILF+L+ G PF+++N + I ++T P S K LI R Sbjct: 210 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 269 Query: 266 ILDPNPATRITFAEVIENEWFKKGYKAP--KFENADVSLDDVDAIFDDSGESKNLVVER 322 +L +P R + E+ + W + +P K+ VS ++ S E N +++R Sbjct: 270 MLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNL------SEEEHNSIIQR 322 >5JN2-A nrPDB Length = 525 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 111/378 (29%), Positives = 191/378 (50%), Gaps = 28/378 (7%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ R LG+G+F +V ++ G A+KVI K +V + + RE+ +K + H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 186 Query: 149 GVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL++ + +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK---MKDKIGTAYYIAPEVLHG 243 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKK 261 K D+WS GVIL++L++G PF +N + KK+ K ++T P W S SAK Sbjct: 244 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 301 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKA------PKFENADVSLDDVDAIFDDS--- 312 LI+++L P+ RI+ + +++EW + K P +NA +++ + Sbjct: 302 LIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAA 361 Query: 313 ---GESKNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSS 369 SK + +E M+ + L+ L E L++ K + S Sbjct: 362 LLYMGSKLTSQDETKELTAIFHKMDK----NGDGQLDRAELIEGYKELMRMKGQDASMLD 417 Query: 370 ANEIVTKIEAAAAPMGFD 387 A+ + +++ + FD Sbjct: 418 ASAVEHEVDQVLDAVDFD 435 >4MVF-A nrPDB Length = 506 Score = 311 bits (797), Expect = 4e-85, Method: Composition-based stats. Identities = 104/334 (31%), Positives = 157/334 (47%), Gaps = 16/334 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 KY + LG+GT+ V + AIK K+++ K I + +EI MK + H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKKLDH 113 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E + IY ++E +G ELFD I NG E A +Q+ +A+ Y HS Sbjct: 114 PNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSL 173 Query: 149 GVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPEN L + + LK+ DFGLS + T GTP YVAP+V++ Sbjct: 174 NIVHRDLKPENFLFQSENKDSLLKIIDFGLSK---NLGTGEFTTTKAGTPYYVAPQVLDG 230 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKK 261 K K D+WS GVI++ L+ GY PF + KK+ K EF S+ AK Sbjct: 231 K--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKN 288 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVE 321 LI ++L NP R T E + + W + K+ + +L F E K + + Sbjct: 289 LITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALT 348 Query: 322 RREEGLKTPVTMNAFELISTSQGLNLGSLFEKQM 355 + L V +N I + ++ Q Sbjct: 349 IIAKHL-CDVEINNLRNIFIALDVDNSGTLSSQE 381 >2HAK-A nrPDB Length = 328 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 116/324 (35%), Positives = 196/324 (60%), Gaps = 14/324 (4%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S++ + +G Y L +T+G+G FAKVK AR+V G VA+K+IDK + L + ++ RE Sbjct: 6 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFRE 64 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q++ Sbjct: 65 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 124 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +AV YCH + + HRDLK ENLLLD + +K++DFG S + L T CG+P Y A Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDTFCGSPPYAA 181 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 182 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 241 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK--------KGYKAPKFENADVSLDDVDAIFDD 311 + L+K++L NP R + +++++ W K Y P + D D+ Sbjct: 242 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGF 301 Query: 312 SGES--KNLVVERREEGLKTPVTM 333 + + L+ ++ +E + T + + Sbjct: 302 ARDEINDALINQKYDEVMATYILL 325 >3MA6-A nrPDB Length = 298 Score = 308 bits (788), Expect = 5e-84, Method: Composition-based stats. Identities = 95/271 (35%), Positives = 156/271 (57%), Gaps = 12/271 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ R LG+G+F +V ++ G A+KVI K +V + + RE+ +K + H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 151 Query: 149 GVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL++ + +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 152 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK---MKDKIGTAYYIAPEVLHG 208 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKK 261 K D+WS GVIL++L++G PF +N + KK+ K ++T P W S SAK Sbjct: 209 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 266 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKA 292 LI+++L P+ RI+ + +++EW + K Sbjct: 267 LIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >3DXN-A nrPDB Length = 287 Score = 307 bits (787), Expect = 7e-84, Method: Composition-based stats. Identities = 91/269 (33%), Positives = 143/269 (53%), Gaps = 12/269 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ + LG G + +V ++ G AIK+I K V + E++ +K + H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E K Y V+E GGELFD+I + E +A +Q+++ Y H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 149 GVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL++ + +K+ DFGLSA G + GT Y+APEV+ Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSA---HFEVGGKMKERLGTAYYIAPEVL-- 195 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKK 261 + K D+WSCGVIL++L+ GY PF + K++ K +F+ P W S AK+ Sbjct: 196 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 255 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGY 290 L+K +L P+ RI+ E + + W K Sbjct: 256 LVKLMLTYEPSKRISAEEALNHPWIVKFC 284 >3HZT-A nrPDB Length = 467 Score = 307 bits (786), Expect = 7e-84, Method: Composition-based stats. Identities = 105/376 (27%), Positives = 174/376 (46%), Gaps = 23/376 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ + LG G + +V ++ G AIK+I K V + E++ +K + H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E K Y V+E GGELFD+I + E +A +Q+++ Y H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 149 GVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL++ + +K+ DFGLSA G + GT Y+APEV+ Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSA---HFEVGGKMKERLGTAYYIAPEVL-- 178 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKK 261 + K D+WSCGVIL++L+ GY PF + K++ K +F+ P W S AK+ Sbjct: 179 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 238 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLV-- 319 L+K +L P+ RI+ E + + W K + +L S+ L Sbjct: 239 LVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQSSQKLAQA 298 Query: 320 --------VERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSAN 371 + EE + + + L+ L E L++ K S ++ Sbjct: 299 AMLFMGSKLTTLEETKELTQIFRQLDN-NGDGQLDRKELIEGYRKLMQWKGDTVSDLDSS 357 Query: 372 EIVTKIEAAAAPMGFD 387 +I +++ + FD Sbjct: 358 QIEAEVDHILQSVDFD 373 >6C9D-A nrPDB Length = 459 Score = 307 bits (786), Expect = 9e-84, Method: Composition-based stats. Identities = 125/393 (31%), Positives = 215/393 (54%), Gaps = 26/393 (6%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S++ + +G Y L +T+G+G FAKVK AR+V G VA+K+IDK + L + ++ RE Sbjct: 12 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFRE 70 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + MK++ HPN++++FEV+ ++ +Y V+E+ +GGE+FD + ++GR+KE EAR F+Q++ Sbjct: 71 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 130 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +AV YCH + + HRDLK ENLLLD + +K++DFG S + L CG+P Y A Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDEFCGSPPYAA 187 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+ K YDG + D+WS GVIL+ L++G LPF+ NL L +++ + ++ P + S Sbjct: 188 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 247 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFK--------KGYKAPKFENADVSLDDVDAIFDD 311 + L+K++L NP R + +++++ W K Y P + D D+ Sbjct: 248 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGF 307 Query: 312 SGES--KNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQ-----MGLVKRKTRF 364 + + L+ ++ +E + T + + + G +L +++ R RF Sbjct: 308 ARDEINDALINQKYDEVMATYILL-GRKPPEFEGGESLSGEPKERDKEEGKDSKPRSLRF 366 Query: 365 ------TSKSSANEIVTKIEAAAAPMGFDVKTN 391 TS N+++ +I D + Sbjct: 367 TWSMKTTSSMDPNDMMREIRKVLDANNCDYEQK 399 >3DFA-A nrPDB Length = 286 Score = 306 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 96/271 (35%), Positives = 154/271 (56%), Gaps = 13/271 (4%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T +Y + LG+G+F +V ++ A+KVI+K KNK + I RE+ +K Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKK 77 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 + HPN++++FE++ + Y V E TGGELFD+I R E +A + +Q+ + + Y Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 146 HSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 H + HRDLKPEN+LL++ + +K+ DFGLS QQ + + GT Y+APEV Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ---NTKMKDRIGTAYYIAPEV 194 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSAS 258 + +G K D+WS GVIL++L++G PF N + K++ ++ P W S Sbjct: 195 L--RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDD 252 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKG 289 AK LI+++L +P+ RIT + +E+ W +K Sbjct: 253 AKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3NCG-A nrPDB Length = 486 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 103/335 (30%), Positives = 179/335 (53%), Gaps = 21/335 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T +Y + LG+G+F +V ++ A+KVI+K KNK + I RE+ +K Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKK 77 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 + HPN++++FE++ + Y V E TGGELFD+I R E +A + +Q+ + + Y Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 146 HSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 H + HRDLKPEN+LL++ + +K+ DFGLS QQ + + GT Y+APEV Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ---NTKMKDRIGTAYYIAPEV 194 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSAS 258 + +G K D+WS GVIL++L++G PF N + K++ ++ P W S Sbjct: 195 L--RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDD 252 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNL 318 AK LI+++L +P+ RIT + +E+ W +K + + ++ D+ ++ +S + Sbjct: 253 AKDLIRKMLTFHPSLRITATQCLEHPWIQK------YSSETPTISDLPSL--ESAMTNIR 304 Query: 319 VVERREEGLKTPVTMNAFELISTSQGLNLGSLFEK 353 + ++ + + A +L + + L +F K Sbjct: 305 QFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRK 339 >5WAX-A nrPDB Length = 310 Score = 303 bits (775), Expect = 2e-82, Method: Composition-based stats. Identities = 116/287 (40%), Positives = 163/287 (56%), Gaps = 15/287 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YEL R +G G F + RN +G VA+K I++ K+ ++REI + ++H Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG----EKIDENVQREIINHRSLRH 66 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+IR EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V YCHS Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 149 GVYHRDLKPENLLLDAN--GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 V HRDLK EN LLD + LK+ DFG S +T GTP Y+APEV+ K Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLKK 183 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFED----SNLTSLYKKIFKAEFTCPP--WFSASAK 260 YDG AD+WSCGV L+V++ G PFED N ++I +++ P S + Sbjct: 184 EYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQ 243 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDA 307 LI RI NPATRIT E+ + WF K A +++ +S + Sbjct: 244 DLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEP 290 >3D2K-A nrPDB Length = 272 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 97/267 (36%), Positives = 153/267 (57%), Gaps = 5/267 (1%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + +++GR LG+G F V AR ++ +A+KV+ K ++ K + Q++RE+ ++ Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++R++ T++Y +LE+ G ++ ++ R E Y +L NA+ YCHS Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHS 130 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + V HRD+KPENLLL +NG LK++DFG S R T CGT +Y+ PE+I + Sbjct: 131 KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----TTLCGTLDYLPPEMIEGRM 186 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 +D K DLWS GV+ + + G PFE Y++I + EFT P + + A+ LI R+L Sbjct: 187 HD-EKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLL 245 Query: 268 DPNPATRITFAEVIENEWFKKGYKAPK 294 N + R+T AEV+E+ W K P Sbjct: 246 KHNASQRLTLAEVLEHPWIKANSSKPS 272 >4UZD-A nrPDB Length = 287 Score = 302 bits (773), Expect = 3e-82, Method: Composition-based stats. Identities = 95/267 (35%), Positives = 150/267 (56%), Gaps = 5/267 (1%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + +E+GR LG+G F V AR ++ +A+KV+ K ++ K + Q++RE+ ++ Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++R++ T++Y +LE+ G ++ ++ + E Y +L NA+ YCHS Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + V HRD+KPENLLL + G LK++DFG S R T CGT +Y+ PE+I + Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR----TTLCGTLDYLPPEMIEGRM 182 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 +D K DLWS GV+ + + G PFE + YK+I + EFT P + + A+ LI R+L Sbjct: 183 HD-EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLL 241 Query: 268 DPNPATRITFAEVIENEWFKKGYKAPK 294 NP+ R EV+E+ W P Sbjct: 242 KHNPSQRPMLREVLEHPWITANSSKPS 268 >5IG1-A nrPDB Length = 344 Score = 300 bits (769), Expect = 7e-82, Method: Composition-based stats. Identities = 97/264 (36%), Positives = 152/264 (57%), Gaps = 12/264 (4%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +G+G F+ V N G+ A+KVI K L++ I +IKREI ++H +++ M Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIAL-KSLRSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 ++ Y V E+V+GGELFD+I + E +A Q+++A+ +CHS+ + HRDL Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 156 KPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 KPENLLL D N +K++DFGL+ + +Q GTP Y++PEVI YD A Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQ---GPTYFGFAGTPGYLSPEVIRRVPYDTA- 198 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP----PWFSASAKKLIKRILD 268 D+W+CGVIL++L+ GY PF + + LY +I ++ P + +AK+LIK +L+ Sbjct: 199 VDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLE 258 Query: 269 PNPATRITFAEVIENEWFKKGYKA 292 PNP R T E++++ W + Sbjct: 259 PNPKRRPTVQELLQHPWIARRDVP 282 >2VN9-A nrPDB Length = 301 Score = 300 bits (769), Expect = 9e-82, Method: Composition-based stats. Identities = 98/265 (36%), Positives = 155/265 (58%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+L LG+G F+ V+ + G A K+I+ +K L + +++RE +L+KH Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLEREARICRLLKH 62 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + ++ + Y V + VTGGELF+ I + E +A QQ++ +V++CH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 149 GVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 G+ HRDLKPENLLL A+K++DFGL+ Q ++ GTP Y++PEV+ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWF--GFAGTPGYLSPEVLRK 180 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 Y G D+W+CGVIL++L+ GY PF D + LY++I +F P W + AK Sbjct: 181 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 239 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NPA RIT +E +++ W Sbjct: 240 LINKMLTINPAKRITASEALKHPWI 264 >1FOT-A nrPDB Length = 318 Score = 300 bits (769), Expect = 9e-82, Method: Composition-based stats. Identities = 93/264 (35%), Positives = 156/264 (59%), Gaps = 11/264 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +++ RTLG G+F +V R+ NG A+KV+ KE V++ K + E + ++ HP Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 +IRM+ +I+ +++++ GGELF + + R A+ Y ++ A++Y HS+ Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKD 126 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 + +RDLKPEN+LLD NG +K++DFG + V +T CGTP+Y+APEV++ K Y+ Sbjct: 127 IIYRDLKPENILLDKNGHIKITDFGFAKYVPDV-----TYTLCGTPDYIAPEVVSTKPYN 181 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDP 269 + D WS G++++ ++AGY PF DSN Y+KI AE PP+F+ K L+ R++ Sbjct: 182 KS-IDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITR 240 Query: 270 NPATRI-----TFAEVIENEWFKK 288 + + R+ +V + WFK+ Sbjct: 241 DLSQRLGNLQNGTEDVKNHPWFKE 264 >3LIJ-A nrPDB Length = 494 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 92/269 (34%), Positives = 150/269 (55%), Gaps = 13/269 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+ + LG G + +V R+ AIK+I K V + +++ E++ +KL+ HPN Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN-SKLLEEVAVLKLLDHPN 97 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++++++ K Y V+E GGELFD+I + E +A +Q+++ V Y H + Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNI 157 Query: 151 YHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL++ + +K+ DFGLSA+ + ++ + GT Y+APEV+ + Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKK---MKERLGTAYYIAPEVL--RK 212 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKKLI 263 K D+WS GVILF+L+AGY PF + +K+ K ++T P W S AK LI Sbjct: 213 KYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKA 292 K++L + RI+ + +E+ W K+ Sbjct: 273 KQMLQFDSQRRISAQQALEHPWIKEMCSK 301 >3ZUT-A nrPDB Length = 362 Score = 297 bits (762), Expect = 5e-81, Method: Composition-based stats. Identities = 118/344 (34%), Positives = 180/344 (52%), Gaps = 21/344 (6%) Query: 15 STPSGSSSGGRTRV---GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK 71 P+ S + +YEL + +G G F + R+ ++ + VA+K I++ K Sbjct: 2 DRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EK 57 Query: 72 MIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEA 131 + +KREI + ++HPN++R EV+ + T + V+E+ +GGELF++I + GR EDEA Sbjct: 58 IDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEA 117 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN--GALKVSDFGLSALPQQVREDGLLH 189 R +FQQLI+ V YCH+ V HRDLK EN LLD + LK+ FG S Sbjct: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK---SSVLHSQPK 174 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED----SNLTSLYKKIF 245 +T GTP Y+APEV+ K YDG AD+WSCGV L+V++ G PFED N +I Sbjct: 175 STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL 234 Query: 246 KAEFTCPP--WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD 303 ++ P S + LI RI +PA RI+ E+ +EWF K A + ++ Sbjct: 235 NVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQ 294 Query: 304 DVDAIFDDSGESKNLVVERREEGLKTPV-TMNAFELISTSQGLN 346 ++ D G+S +++ E P T N ++ S ++ Sbjct: 295 FDES--DQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDID 336 >4I6B-A nrPDB Length = 308 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 87/270 (32%), Positives = 152/270 (56%), Gaps = 3/270 (1%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y G+TLG+G FAK ++ N A K+I +V K +I +EI +++ H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 +V++ + K IY +LE+ + + + + L E E R Y +Q+++ + Y H + Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ 147 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 + HRDLK N ++ + LKV DFGL+A + + T CGTPNY++PEV+N +G+ Sbjct: 148 EILHRDLKLGNFFINESMELKVGDFGLAARLEPLEH--RRRTICGTPNYLSPEVLNKQGH 205 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 GA++D+W+ G +++ ++ G PFE +NL Y+ I +A +T P A AK LI +L Sbjct: 206 -GAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLS 264 Query: 269 PNPATRITFAEVIENEWFKKGYKAPKFENA 298 NP R + ++I +++F +G+ + ++ Sbjct: 265 KNPEDRPSLDDIIRHDFFTQGFTPDRLSSS 294 >4YZB-A nrPDB Length = 491 Score = 297 bits (760), Expect = 9e-81, Method: Composition-based stats. Identities = 119/418 (28%), Positives = 200/418 (47%), Gaps = 46/418 (11%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ R LG+G+F +V ++ G A+KVI K +V + + +E+ +K + H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN+++++E K Y V E TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 149 GVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL+ + +++ DFGLS + ++ + GT Y+APEV++ Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKK---MKDKIGTAYYIAPEVLHG 206 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKK 261 K D+WS GVIL++L++G PF +N + KK+ K +FT P W S AK Sbjct: 207 T--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKD 264 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVE 321 LI+++L P RI+ + +E+EW K D + D +D +S + Sbjct: 265 LIRKMLAYVPTMRISARDALEHEWLK---------TTDAATDSIDVPSLESTILNIRQFQ 315 Query: 322 RREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAA 381 ++ + +L + + + L +F++ + E++ Sbjct: 316 GTQKLAAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQL------DKQELMEGYVEL- 368 Query: 382 APMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKF 439 MKL GE Q A+ EV QV + V+ K+G +E+ +F Sbjct: 369 -------------MKLKGEDVSALDQSAIEFEVEQVLDA---VDFDKNG--FIEYSEF 408 >2VZ6-A nrPDB Length = 313 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 101/263 (38%), Positives = 153/263 (58%), Gaps = 11/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L LG+G F+ V+ V G A K+I+ +K L + +++RE +L+KHPN Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 82 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH GV Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVE--GEQQAWFGFAGTPGYLSPEVLRKDP 200 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKKLI 263 Y G DLW+CGVIL++L+ GY PF D + LY++I +F P W + AK LI Sbjct: 201 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 259 Query: 264 KRILDPNPATRITFAEVIENEWF 286 ++L NP+ RIT AE +++ W Sbjct: 260 NKMLTINPSKRITAAEALKHPWI 282 >4B6L-A nrPDB Length = 281 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 94/275 (34%), Positives = 147/275 (53%), Gaps = 4/275 (1%) Query: 25 RTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 R G+ Y GR LG+G FA+ A + E G A+KVI + +V K +I EI Sbjct: 4 DPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH 63 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 + ++H +++R IY LE + L + L E E R Y +Q+++ + Sbjct: 64 RDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLK 123 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 Y H RG+ HRDLK N + N LKV DFGL+A + + T CGTPNYVAPEV+ Sbjct: 124 YLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEP--PEQRKKTICGTPNYVAPEVL 181 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 +G+ G +AD+WS G +++ L+ G PFE ++L Y+ I + +T P S A++L+ Sbjct: 182 LRQGH-GPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLL 240 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENA 298 IL +P R + +++ +++F KGY + + Sbjct: 241 AAILRASPRDRPSIDQILRHDFFTKGYTPDRLPIS 275 >5FG8-A nrPDB Length = 285 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 95/265 (35%), Positives = 148/265 (55%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y++ LG+G F+ VK G A K+I+ +K L + +++RE + + H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKK-LTARDFQKLEREARICRKLHH 72 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + + + Y V + VTGGELF+ I + E +A QQ++ +V++CH Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 149 GVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 GV HRDLKPENLLL + +K++DFGL+ Q + GTP Y++PEV+ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWF--GFAGTPGYLSPEVLKK 190 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 + Y G D+W+CGVIL++L+ GY PF D + LY +I ++ P W + AK Sbjct: 191 EPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKN 249 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NP RIT AE +++ W Sbjct: 250 LINQMLTVNPNKRITAAEALKHPWI 274 >5U6Y-A nrPDB Length = 461 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 101/263 (38%), Positives = 153/263 (58%), Gaps = 11/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+L LG+G F+ V+ V G A K+I+ +K L + +++RE +L+KHPN Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK-LSARDHQKLEREARICRLLKHPN 60 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH GV Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 151 YHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVE--GEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKKLI 263 Y G DLW+CGVIL++L+ GY PF D + LY++I +F P W + AK LI Sbjct: 179 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 237 Query: 264 KRILDPNPATRITFAEVIENEWF 286 ++L NP+ RIT AE +++ W Sbjct: 238 NKMLTINPSKRITAAEALKHPWI 260 >2V7O-A nrPDB Length = 336 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 93/265 (35%), Positives = 147/265 (55%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y+L LG+G F+ V+ A K+I+ +K L + +++RE +L+KH Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKK-LSARDHQKLEREARICRLLKH 89 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + ++ + Y V + VTGGELF+ I + E +A Q++ +V++ H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 149 GVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + HRDLKPENLLL + +K++DFGL+ Q E GTP Y++PEV+ Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ--GEQQAWFGFAGTPGYLSPEVLRK 207 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 Y G D+W+CGVIL++L+ GY PF D + LY++I +F P W + AK Sbjct: 208 DPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 266 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NPA RIT + +++ W Sbjct: 267 LINQMLTINPAKRITADQALKHPWV 291 >4FG9-A nrPDB Length = 320 Score = 294 bits (752), Expect = 8e-80, Method: Composition-based stats. Identities = 104/280 (37%), Positives = 154/280 (55%), Gaps = 13/280 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y+ LG G F++V A + VAIK I KE + + ++ EI+ + IKHPN Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG--SMENEIAVLHKIKHPN 77 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ + ++ S +Y +++ V+GGELFD+I G E +A + Q+++AV Y H G+ Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 151 YHRDLKPENLL---LDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLL LD + + +SDFGLS + +L T CGTP YVAPEV+ K Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKME---DPGSVLSTACGTPGYVAPEVLAQKP 194 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAKKLI 263 Y D WS GVI ++L+ GY PF D N L+++I KAE+ P W S SAK I Sbjct: 195 Y-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFI 253 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD 303 + +++ +P R T + +++ W K + VS Sbjct: 254 RHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQ 293 >3BHH-A nrPDB Length = 295 Score = 293 bits (751), Expect = 8e-80, Method: Composition-based stats. Identities = 97/265 (36%), Positives = 153/265 (57%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+L +G+G F+ V+ + G A K+I+ +K L + +++RE +L+KH Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLEREARICRLLKH 62 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 N++R+ + ++ + Y V + VTGGELF+ I + E +A QQ++ AV +CH Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 149 GVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 GV HRDLKPENLLL + +K++DFGL+ Q ++ GTP Y++PEV+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWF--GFAGTPGYLSPEVLRK 180 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 + Y G D+W+CGVIL++L+ GY PF D + LY++I +F P W + AK Sbjct: 181 EAY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 239 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NPA RIT E +++ W Sbjct: 240 LINQMLTINPAKRITAHEALKHPWV 264 >4JXF-A nrPDB Length = 266 Score = 293 bits (751), Expect = 9e-80, Method: Composition-based stats. Identities = 86/264 (32%), Positives = 150/264 (56%), Gaps = 4/264 (1%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 ++ +++G LG+G+FA V A ++ G VAIK+IDK+ + K M+ +++ E+ + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYC 145 KHP+++ ++ +Y VLE GE+ + + E+EAR + Q+I + Y Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS G+ HRDL NLLL N +K++DFGL+ + E +T CGTPNY++PE I Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKH--YTLCGTPNYISPE-IAT 181 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 + G ++D+WS G + + L+ G PF+ + + K+ A++ P + S AK LI + Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQ 241 Query: 266 ILDPNPATRITFAEVIENEWFKKG 289 +L NPA R++ + V+++ + + Sbjct: 242 LLRRNPADRLSLSSVLDHPFMSRN 265 >3TXO-A nrPDB Length = 353 Score = 293 bits (751), Expect = 1e-79, Method: Composition-based stats. Identities = 101/335 (30%), Positives = 169/335 (50%), Gaps = 19/335 (5%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G +S R + +E R LG+G+F KV AR E GD A+KV+ K+ +L++ + Sbjct: 13 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 72 Query: 79 EISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E + L + HP + ++F + +++FV+EFV GG+L I + R E AR Y + Sbjct: 73 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 132 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +I+A+ + H +G+ +RDLK +N+LLD G K++DFG+ + + T CGTP+Y Sbjct: 133 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDY 190 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 +APE++ Y G D W+ GV+L+ ++ G+ PFE N L++ I E P W Sbjct: 191 IAPEILQEMLY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHE 249 Query: 258 SAKKLIKRILDPNPATRI-TFAE-----VIENEWFKK--------GYKAPKFENADVSLD 303 A ++K + NP R+ + + ++ + +FK+ P F S + Sbjct: 250 DATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSRE 309 Query: 304 DVDAIFDDSGESKNLVVERREEGLKTPVTMNAFEL 338 DV FD + V+ +EG + + F Sbjct: 310 DVSN-FDPDFIKEEPVLTPIDEGHLPMINQDEFRN 343 >2BDW-A nrPDB Length = 362 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 96/295 (32%), Positives = 157/295 (53%), Gaps = 15/295 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y++ LG+G F+ V+ + G A K+I+ +K L + +++RE + ++H Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQH 87 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + + ++ Y V + VTGGELF+ I + E +A QQ++ ++ YCHS Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 149 GVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 G+ HR+LKPENLLL + +K++DFGL+ +V + H GTP Y++PEV+ Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAI---EVNDSEAWHGFAGTPGYLSPEVLKK 204 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 Y D+W+CGVIL++L+ GY PF D + LY +I ++ P W + AK Sbjct: 205 DPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKS 263 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESK 316 LI +L NP RIT + ++ W + +A D VD + + K Sbjct: 264 LIDSMLTVNPKKRITADQALKVPWI---CNRERVASAIHRQDTVDCLKKFNARRK 315 >3DB8-A nrPDB Length = 317 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 95/291 (32%), Positives = 146/291 (50%), Gaps = 5/291 (1%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 +S P + P + +Y GR LG+G FAK +++ + A KV+ K + Sbjct: 23 PKSAPLKEIPDVLVDP--RTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSML 80 Query: 68 LKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK 127 LK ++ EI+ K + +P+V+ +Y VLE L + + Sbjct: 81 LKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVT 140 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL 187 E EAR + +Q I V Y H+ V HRDLK NL L+ + +K+ DFGL+ + E Sbjct: 141 EPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGE--R 198 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA 247 CGTPNY+APEV+ KG+ + D+WS G IL+ L+ G PFE S L Y +I K Sbjct: 199 KKDLCGTPNYIAPEVLCKKGH-SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKN 257 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENA 298 E++ P + A LI+R+L +P R + AE++ +E+F GY + + Sbjct: 258 EYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTS 308 >3KK8-A nrPDB Length = 284 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 95/287 (33%), Positives = 155/287 (54%), Gaps = 15/287 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y++ LG+G F+ V+ + G A K+I+ +K L + +++RE + ++H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKK-LSARDFQKLEREARICRKLQH 64 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + + ++ Y V + VTGGELF+ I + E +A QQ++ ++ YCHS Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 149 GVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 G+ HR+LKPENLLL + +K++DFGL+ +V + H GTP Y++PEV+ Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAI---EVNDSEAWHGFAGTPGYLSPEVLKK 181 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 Y D+W+CGVIL++L+ GY PF D + LY +I ++ P W + AK Sbjct: 182 DPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKS 240 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAI 308 LI +L NP RIT + ++ W + +A D VD + Sbjct: 241 LIDSMLTVNPKKRITADQALKVPWI---CNRERVASAIHRQDTVDCL 284 >2JDO-A nrPDB Length = 342 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 93/309 (30%), Positives = 159/309 (51%), Gaps = 17/309 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + + ++ + LG+GTF KV R G A+K++ KE ++ +A E ++ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S E+ AR Y ++++A++Y Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HSR V +RD+K ENL+LD +G +K++DFGL + + + + T CGTP Y+APEV+ Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLE 183 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 + Y G D W GV+++ +M G LPF + + L++ I E P S AK L+ Sbjct: 184 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLA 242 Query: 265 RILDPNPATRIT-----FAEVIENEWF--------KKGYKAPKFENADVSLDDVDAIFDD 311 +L +P R+ EV+E+ +F + P F+ S D FDD Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDT-RYFDD 301 Query: 312 SGESKNLVV 320 ++++ + Sbjct: 302 EFTAQSITI 310 >2JC6-A nrPDB Length = 334 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 102/278 (36%), Positives = 154/278 (55%), Gaps = 17/278 (6%) Query: 20 SSSGGRTRVGK----YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 SSS + + +E TLG G F++V A G A+K I K+ + + + Sbjct: 9 SSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SS 66 Query: 76 IKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 I+ EI+ ++ IKH N++ + ++ S +Y V++ V+GGELFD+I G E +A Sbjct: 67 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 126 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTC 192 +Q+++AV Y H G+ HRDLKPENLL D + +SDFGLS + + ++ T C Sbjct: 127 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME---GKGDVMSTAC 183 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC- 251 GTP YVAPEV+ K Y D WS GVI ++L+ GY PF D N + L+++I KAE+ Sbjct: 184 GTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFD 242 Query: 252 -PPW--FSASAKKLIKRILDPNPATRITFAEVIENEWF 286 P W S SAK I+ +++ +P R T + + W Sbjct: 243 SPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4L42-A nrPDB Length = 346 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 99/331 (29%), Positives = 167/331 (50%), Gaps = 21/331 (6%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKN- 70 S S + + R +EL R LG+G + KV R V G A+KV+ K +++N Sbjct: 4 SETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 63 Query: 71 KMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE 130 K A K E + ++ +KHP ++ + + K+Y +LE+++GGELF ++ G ED Sbjct: 64 KDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 123 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT 190 A Y ++ A+ + H +G+ +RDLKPEN++L+ G +K++DFGL + + + + HT Sbjct: 124 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK--ESIHDGTVTHT 181 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT 250 CGT Y+APE++ G++ D WS G +++ ++ G PF N KI K + Sbjct: 182 FCGTIEYMAPEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 240 Query: 251 CPPWFSASAKKLIKRILDPNPATRIT-----FAEVIENEWFK--------KGYKAPKFEN 297 PP+ + A+ L+K++L N A+R+ EV + +F+ P F+ Sbjct: 241 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 300 Query: 298 ADVSLDDVDAIFDDSGESKNLVVERREEGLK 328 S +DV FD + V + L Sbjct: 301 LLQSEEDVSQ-FDSKFTRQTPVDSPDDSTLS 330 >3UC3-A nrPDB Length = 361 Score = 291 bits (745), Expect = 5e-79, Method: Composition-based stats. Identities = 100/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ + +G G F + R+ + VA+K I++ + ++REI + ++H Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID----ENVQREIINHRSLRH 75 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R EV+ + T + ++E+ +GGEL+++I + GR EDEAR +FQQL++ V YCHS Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 149 GVYHRDLKPENLLLDAN--GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLK EN LLD + LK+ DFG S +T GTP Y+APEV+ + Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFED----SNLTSLYKKIFKAEFTCPP--WFSASAK 260 YDG AD+WSCGV L+V++ G PFED + ++I +++ P S Sbjct: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 LI RI +PATRI+ E+ + WF K A Sbjct: 253 HLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 >3MV5-A nrPDB Length = 342 Score = 291 bits (744), Expect = 6e-79, Method: Composition-based stats. Identities = 92/310 (29%), Positives = 160/310 (51%), Gaps = 18/310 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 145 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 183 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 184 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 242 Query: 264 KRILDPNPATRIT-----FAEVIENEWFK--------KGYKAPKFENADVSLDDVDAIFD 310 +L +P R+ E++++ +F + +P F+ S D FD Sbjct: 243 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT-RYFD 301 Query: 311 DSGESKNLVV 320 + ++ + + Sbjct: 302 EEFTAQMITI 311 >3UDB-A nrPDB Length = 317 Score = 290 bits (743), Expect = 8e-79, Method: Composition-based stats. Identities = 109/290 (37%), Positives = 157/290 (54%), Gaps = 17/290 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YEL + +G G F + R+ + + VA+K I++ K+ +KREI + ++H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG----EKIDENVKREIINHRSLRH 74 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R EV+ + T + V+E+ +GGELF++I + GR EDEAR +FQQLI+ V Y H+ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 149 GVYHRDLKPENLLLDAN--GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 V HRDLK EN LLD + LK++DFG S + GTP Y+APEV+ K Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKAS---VLHSQPKSAVGTPAYIAPEVLLKK 191 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFED----SNLTSLYKKIFKAEFTCPP--WFSASAK 260 YDG AD+WSCGV L+V++ G PFED N +I ++ P S + Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKAP--KFENADVSLDDVDAI 308 LI RI +PA RI+ E+ +EWF K A D+ D Sbjct: 252 HLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQP 301 >5KCV-A nrPDB Length = 460 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 92/303 (30%), Positives = 156/303 (51%), Gaps = 18/303 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 158 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 217 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 218 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 145 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 335 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 336 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 394 Query: 264 KRILDPNPATRIT-----FAEVIENEWFK--------KGYKAPKFENADVSLDDVDAIFD 310 +L +P R+ E++++ +F + +P F+ S D FD Sbjct: 395 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT-RYFD 453 Query: 311 DSG 313 + Sbjct: 454 EEF 456 >3Q5I-A nrPDB Length = 504 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 98/276 (35%), Positives = 142/276 (51%), Gaps = 22/276 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK----------NKMIAQIKREI 80 Y R LG G + +V + AIKVI K + K K +I EI Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 S +K + HPN+I++F+V K Y V EF GGELF++I + + E +A +Q+++ Sbjct: 98 SLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILS 157 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANG---ALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + Y H + HRD+KPEN+LL+ +K+ DFGLS+ +D L GT Y Sbjct: 158 GICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSF---FSKDYKLRDRLGTAYY 214 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPPW- 254 +APEV+ K K D+WSCGVI+++L+ GY PF N + KK+ K + F W Sbjct: 215 IAPEVLKKK--YNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWK 272 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 S AK+LIK +L + R T E + + W KK Sbjct: 273 NISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >4RLP-A nrPDB Length = 288 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 88/272 (32%), Positives = 151/272 (55%), Gaps = 12/272 (4%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKN-KMIAQIKREI 80 + R +EL R LG+G + KV R V G A+KV+ K +++N K A K E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 + ++ +KHP ++ + + K+Y +LE+++GGELF ++ G ED A Y ++ Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 A+ + H +G+ +RDLKPEN++L+ G +K++DFGL + + + + HT CGT Y+AP Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK--ESIHDGTVTHTFCGTIEYMAP 178 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E++ G++ D WS G +++ ++ G PF N KI K + PP+ + A+ Sbjct: 179 EILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 237 Query: 261 KLIKRILDPNPATRIT-----FAEVIENEWFK 287 L+K++L N A+R+ EV + +F+ Sbjct: 238 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR 269 >2JAM-A nrPDB Length = 304 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 101/273 (36%), Positives = 149/273 (54%), Gaps = 16/273 (5%) Query: 22 SGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S T + K + LG G F++V + G A+K I K ++ + EI Sbjct: 1 SMQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE---NEI 57 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 + +K IKH N++ + ++ S T Y V++ V+GGELFD+I G E +A QQ+++ Sbjct: 58 AVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLS 117 Query: 141 AVDYCHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 AV Y H G+ HRDLKPENLL + N + ++DFGLS + Q +G++ T CGTP Y Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ----NGIMSTACGTPGY 173 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW- 254 VAPEV+ K Y D WS GVI ++L+ GY PF + + L++KI + EF P W Sbjct: 174 VAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWD 232 Query: 255 -FSASAKKLIKRILDPNPATRITFAEVIENEWF 286 S SAK I +L+ +P R T + + + W Sbjct: 233 DISESAKDFICHLLEKDPNERYTCEKALSHPWI 265 >4RGJ-A nrPDB Length = 520 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 128/461 (27%), Positives = 216/461 (46%), Gaps = 41/461 (8%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ + LG+G+F +V +R+ G AIKVI K+ V + + RE+ +K++ H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 N+++++E Y V + TGGELFD+I S R E +A + +Q+++ + Y H Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKN 179 Query: 149 GVYHRDLKPENLLLD----ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 V HRDLKPEN+LL+ + +K+ DFGLS + ++ + GT Y+AP+V++ Sbjct: 180 NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK---MKDKIGTAYYIAPDVLH 236 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC--PPW--FSASAK 260 K D+WSCGVIL++L++G PF SN + KK+ ++T P + S AK Sbjct: 237 GT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAK 294 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKK-------GYKAPKFENADVSLDDVDAIFDDS- 312 LIK++L A RI+ + +E+EW K P E + ++ + + Sbjct: 295 DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQ 354 Query: 313 -----GESKNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSK 367 SK ++ +E K M+ + L+ L L+K K TS Sbjct: 355 AALLYMGSKLTTIDETKELTKIFKKMDK----NGDGQLDRNELIIGYKELLKLKGEDTSD 410 Query: 368 SSANEIVTKIEAAAAPMGFDVKTNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMR 427 I +++ + D N Y +L ++TE + A L+ Sbjct: 411 LDNAAIEYEVDQILNSIDLD--QNGYIEYSEFLTVSIDRKLLLSTERLEKAFKLF----D 464 Query: 428 KSGGDTLEFHKFYKNLTTGLKDI---VWKTIDEEKEEGTDG 465 K G + ++ + GL D+ WKT+ +E ++ DG Sbjct: 465 KDGSGKISANELAQLF--GLSDVSSECWKTVLKEVDQNNDG 503 >3SOA-A nrPDB Length = 444 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 99/265 (37%), Positives = 151/265 (56%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+L LG+G F+ V+ V G A +I K L + +++RE +L+KH Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAA-MIINTKKLSARDHQKLEREARICRLLKH 69 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++R+ + ++ + Y + + VTGGELF+ I + E +A QQ++ AV +CH Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 149 GVYHRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 GV HR+LKPENLLL + A+K++DFGL+ + E GTP Y++PEV+ Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVE--GEQQAWFGFAGTPGYLSPEVLRK 187 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPW--FSASAKK 261 Y G DLW+CGVIL++L+ GY PF D + LY++I +F P W + AK Sbjct: 188 DPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 LI ++L NP+ RIT AE +++ W Sbjct: 247 LINKMLTINPSKRITAAEALKHPWI 271 >5D9K-A nrPDB Length = 330 Score = 287 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 86/266 (32%), Positives = 151/266 (56%), Gaps = 12/266 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 ++EL + LG+G+F KV + + + A+KV+ K LK + + K E + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKK-ATLKVRDRVRTKMERDILVE 88 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 + HP ++++ ++ K+Y +L+F+ GG+LF ++S E++ + Y +L A+D+ Sbjct: 89 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS G+ +RDLKPEN+LLD G +K++DFGLS + + + ++ CGT Y+APEV+N Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSK--ESIDHEKKAYSFCGTVEYMAPEVVNR 206 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 +G+ + AD WS GV++F ++ G LPF+ + I KA+ P + S A+ L++ Sbjct: 207 RGHTQS-ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRM 265 Query: 266 ILDPNPATRITF-----AEVIENEWF 286 + NPA R+ E+ + +F Sbjct: 266 LFKRNPANRLGAGPDGVEEIKRHSFF 291 >5XZW-A nrPDB Length = 471 Score = 287 bits (734), Expect = 8e-78, Method: Composition-based stats. Identities = 91/305 (29%), Positives = 155/305 (50%), Gaps = 24/305 (7%) Query: 1 MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELG-RTLGEGTFAKVKFARNVENGDNVAI 59 + + + + + ST S + + + +G+G FA VK A G A+ Sbjct: 167 LKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAV 226 Query: 60 KVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK 119 K+I K KV+ N + + RE+ ++ + HP ++R+ Y V+EFV+GG+L D Sbjct: 227 KIISKRKVIGN--MDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDF 284 Query: 120 ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSA 177 ++++G + ED R+ +Q++ A+ Y HS G+ HRDLKP+N+L++ + +K++DFGL+ Sbjct: 285 VAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAK 344 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVINNKGY------------DGAKADLWSCGVILFVL 225 + + T CGT YVAPEVI K + D+WS G +++V+ Sbjct: 345 VQ---GNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVI 401 Query: 226 MAGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSASAKKLIKRILDPNPATRITFAEVI 281 + G+LPF S LYK+I + + P S A+ I +L +P R T A+ + Sbjct: 402 LTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKAL 461 Query: 282 ENEWF 286 + W Sbjct: 462 NHPWI 466 >3HDN-A nrPDB Length = 373 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 143/273 (52%), Gaps = 8/273 (2%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G SS + + + +G+G+F KV AR+ A+KV+ K+ +LK K I Sbjct: 28 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 87 Query: 79 EISTM-KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E + + K +KHP ++ + + K+YFVL+++ GGELF + E AR Y + Sbjct: 88 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 147 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + +A+ Y HS + +RDLKPEN+LLD+ G + ++DFGL + + + T CGTP Y Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK--ENIEHNSTTSTFCGTPEY 205 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 +APEV++ + YD D W G +L+ ++ G PF N +Y I P + Sbjct: 206 LAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITN 264 Query: 258 SAKKLIKRILDPNPATRIT----FAEVIENEWF 286 SA+ L++ +L + R+ F E+ + +F Sbjct: 265 SARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >4RA4-A nrPDB Length = 355 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 81/284 (28%), Positives = 152/284 (53%), Gaps = 9/284 (3%) Query: 11 TPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 +PS S++ R ++ + LG+G+F KV A + AIK++ K+ V+++ Sbjct: 2 SPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQD 61 Query: 71 KMIAQIKREISTMKLIKHP-NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED 129 + E + L+ P + ++ + ++YFV+E+V GG+L I G+ KE Sbjct: 62 DDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEP 121 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 +A Y ++ + + H RG+ +RDLK +N++LD+ G +K++DFG+ + + + Sbjct: 122 QAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCK--EHMMDGVTTR 179 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEF 249 T CGTP+Y+APE+I + Y G D W+ GV+L+ ++AG PF+ + L++ I + Sbjct: 180 TFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV 238 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITF-----AEVIENEWFKK 288 + P S A + K ++ +PA R+ +V E+ +F++ Sbjct: 239 SYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRR 282 >5X3F-B nrPDB Length = 393 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 89/272 (32%), Positives = 153/272 (56%), Gaps = 11/272 (4%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 + S ++ +++ +TLG G+F +V ++ E+G++ A+K++DK+KV+K K I E Sbjct: 75 TPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNE 134 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 ++ + P ++++ + +Y V+E+V GGE+F + GR E AR Y Q++ Sbjct: 135 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIV 194 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +Y HS + +RDLKPENLL+D G ++V+DFG + + G T CGTP Y+A Sbjct: 195 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCGTPEYLA 249 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ Sbjct: 250 PEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 308 Query: 260 KKLIKRILDPNPATRI-----TFAEVIENEWF 286 K L++ +L + R ++ ++WF Sbjct: 309 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >4WB7-A nrPDB Length = 405 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 90/272 (33%), Positives = 151/272 (55%), Gaps = 11/272 (4%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S + + ++E +TLG G+F +V ++ E G++ A+K++DK+KV+K K I E Sbjct: 87 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 146 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 ++ + P ++++ + +Y V+E+V GGE+F + GR E AR Y Q++ Sbjct: 147 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 206 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +Y HS + +RDLKPENLL+D G ++V+DFG + + G T CGTP Y+A Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCGTPEYLA 261 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ Sbjct: 262 PEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 320 Query: 260 KKLIKRILDPNPATRI-----TFAEVIENEWF 286 K L++ +L + R ++ ++WF Sbjct: 321 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >2Z7Q-A nrPDB Length = 321 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 95/292 (32%), Positives = 159/292 (54%), Gaps = 20/292 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 +EL + LG+G+F KV R V ++G A+KV+ K LK + + K E + Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILAD 86 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 + HP V+++ ++ K+Y +L+F+ GG+LF ++S E++ + Y +L +D+ Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 146 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS G+ +RDLKPEN+LLD G +K++DFGLS + + + ++ CGT Y+APEV+N Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCGTVEYMAPEVVNR 204 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 265 +G+ AD WS GV++F ++ G LPF+ + I KA+ P + S A+ L++ Sbjct: 205 QGH-SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRA 263 Query: 266 ILDPNPATRI-----TFAEVIENEWF-----KKGYKA---PKFENADVSLDD 304 + NPA R+ E+ + ++ K Y+ P F+ A DD Sbjct: 264 LFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDD 315 >3F3Z-A nrPDB Length = 277 Score = 284 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 100/272 (36%), Positives = 151/272 (55%), Gaps = 16/272 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y L T+G G++ +VK A A K I K V + + + K+EI MK + HPN Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPN 67 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +IR++E T IY V+E TGGELF+++ +E +A + + +++AV YCH V Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 151 YHRDLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPEN L + LK+ DFGL+A + + ++ T GTP YV+P+V+ Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAA---RFKPGKMMRTKVGTPYYVSPQVLEGL- 183 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLI 263 G + D WS GV+++VL+ GY PF + + KI + FT P S A+ LI Sbjct: 184 -YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLI 242 Query: 264 KRILDPNPATRITFAEVIENEWF-KKGYKAPK 294 +R+L +P RIT + +E+EWF K+ +P+ Sbjct: 243 RRLLTKSPKQRITSLQALEHEWFEKQLSSSPR 274 >2OU7-A nrPDB Length = 335 Score = 284 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 91/278 (32%), Positives = 138/278 (49%), Gaps = 14/278 (5%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG+G FAK + + + A K++ K +LK ++ EIS + + H +V+ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 ++ VLE L + L E EAR Y +Q++ Y H V HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 NL L+ + +K+ DFGL+ + E CGTPNY+APEV++ KG+ + D+W Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGE--RKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 225 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRIT 276 S G I++ L+ G PFE S L Y +I K E++ P + A LI+++L +P R T Sbjct: 226 SIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 285 Query: 277 FAEVIENEWFKKGY-----------KAPKFENADVSLD 303 E++ +E+F GY P+F A SLD Sbjct: 286 INELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLD 323 >5N23-A nrPDB Length = 352 Score = 284 bits (726), Expect = 8e-77, Method: Composition-based stats. Identities = 91/272 (33%), Positives = 148/272 (54%), Gaps = 10/272 (3%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S + + ++E RTLG G+F +V ++ E G++ A+K++DK+KV+K K I E Sbjct: 33 SPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + + P ++++ + +Y VLE+ GGE+F + GR E AR Y Q++ Sbjct: 93 KRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +Y HS + +RDLKPENLL+D G +KV+DFG + + T CGTP Y+A Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK----GRTPWTLCGTPEYLA 208 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 PE+I +KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ Sbjct: 209 PEIILSKGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 267 Query: 260 KKLIKRILDPNPATRI-----TFAEVIENEWF 286 K L++ +L + R ++ ++WF Sbjct: 268 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >4B8L-A nrPDB Length = 286 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 93/268 (34%), Positives = 153/268 (57%), Gaps = 5/268 (1%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + + +++GR LG+G F V AR +N +A+KV+ K ++ K + Q++REI Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQS 70 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 ++HPN++RM+ + +IY +LEF GEL+ ++ +GR E + + ++L +A+ Y Sbjct: 71 HLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHY 130 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 CH R V HRD+KPENLL+ G LK++DFG S +R T CGT +Y+ PE+I Sbjct: 131 CHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRR----RTMCGTLDYLPPEMIE 186 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 K +D K DLW GV+ + + G PF+ + T +++I + PP+ S +K LI Sbjct: 187 GKTHD-EKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLIS 245 Query: 265 RILDPNPATRITFAEVIENEWFKKGYKA 292 ++L +P R+ V+E+ W K + Sbjct: 246 KLLRYHPPQRLPLKGVMEHPWVKANSRR 273 >6FDY-U nrPDB Length = 276 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 89/274 (32%), Positives = 143/274 (52%), Gaps = 11/274 (4%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIK 77 G R+ + L LG GT+A V A + + VAIK + K+ + K + + Sbjct: 1 AGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS-VENLL 59 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 EI +K I+HP+++++ + IY ++EF GG+L I + L E AR + QQ Sbjct: 60 TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 119 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLD--ANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 L +A+ + H R + H DLKP+N+LL LK++DFG + Q + H G+P Sbjct: 120 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFA---QHMSPWDEKHVLRGSP 176 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK---AEFTCP 252 Y+APE++ + YD A+ DLWS GVIL+ + G PF + + L +KI E Sbjct: 177 LYMAPEMVCQRQYD-ARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLR 235 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 P S + L++R+L+ +P+ RI+F + + W Sbjct: 236 PLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 269 >5F9E-A nrPDB Length = 353 Score = 282 bits (721), Expect = 3e-76, Method: Composition-based stats. Identities = 86/317 (27%), Positives = 157/317 (49%), Gaps = 7/317 (2%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + ++ +EL + LG+G+F KV A + AIK + K+ VL + + E + Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 L +HP + MF +K ++FV+E++ GG+L I S + A Y ++I + Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + HS+G+ +RDLK +N+LLD +G +K++DFG+ + + D + CGTP+Y+APE++ Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK--ENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y+ + D WS GV+L+ ++ G PF + L+ I P W AK L+ Sbjct: 193 LGQKYNHS-VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLL 251 Query: 264 KRILDPNPATRITFA-EVIENEWFKK--GYKAPKFENADVSLDDVDAIFDDSGESKNLVV 320 ++ P R+ ++ ++ F++ + + E V + FD S K + Sbjct: 252 VKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLN 311 Query: 321 ERREEGLKTPVTMNAFE 337 E+ +N+ + Sbjct: 312 EKPRLSFADRALINSMD 328 >4J52-A nrPDB Length = 293 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 85/260 (32%), Positives = 132/260 (50%), Gaps = 3/260 (1%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG+G FAK + + + A K++ K +LK ++ EIS + + H +V+ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 ++ VLE L + L E EAR Y +Q++ Y H V HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 NL L+ + +K+ DFGL+ + E CGTPNY+APEV++ KG+ + D+W Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGE--RKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 198 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRIT 276 S G I++ L+ G PFE S L Y +I K E++ P + A LI+++L +P R T Sbjct: 199 SIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 258 Query: 277 FAEVIENEWFKKGYKAPKFE 296 E++ +E+F GY + Sbjct: 259 INELLNDEFFTSGYIPARLP 278 >4NIF-A nrPDB Length = 333 Score = 281 bits (718), Expect = 6e-76, Method: Composition-based stats. Identities = 93/278 (33%), Positives = 147/278 (52%), Gaps = 22/278 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 Y + T+G G++++ K + A+KVIDK K ++ EI + + +HP Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLRYGQHP 62 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+I + +V +Y V E + GGEL DKI E EA + V+Y HS+G Sbjct: 63 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 122 Query: 150 VYHRDLKPENLL-LDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 V HRDLKP N+L +D +G L++ DFG + + E+GLL T C T N+VAPEV+ Sbjct: 123 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVLKR 180 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIFKAEFTCP----PWFSAS 258 +GYD D+WS G++L+ ++AGY PF + +I +FT S + Sbjct: 181 QGYD-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSET 239 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFE 296 AK L+ ++L +P R+T +V+++ W + K P+ + Sbjct: 240 AKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQ 277 >6CMJ-A nrPDB Length = 321 Score = 281 bits (718), Expect = 6e-76, Method: Composition-based stats. Identities = 94/282 (33%), Positives = 153/282 (54%), Gaps = 17/282 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK--------NKMIAQIK 77 ++ +Y L +G+G++ VK A N + A+KV+ K+K+++ I Q+ Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 78 REISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 +EI+ +K + HPNV+++ EV+ + +Y V E V G + + + + L ED+AR YF Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYF 149 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q LI ++Y H + + HRD+KP NLL+ +G +K++DFG+S + D LL T GTP Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTP 207 Query: 196 NYVAPEVINN--KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP- 252 ++APE ++ K + G D+W+ GV L+ + G PF D + L+ KI P Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 267 Query: 253 -PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 P + K LI R+LD NP +RI E+ + W + P Sbjct: 268 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 309 >5JZN-A nrPDB Length = 280 Score = 281 bits (718), Expect = 7e-76, Method: Composition-based stats. Identities = 101/273 (36%), Positives = 154/273 (56%), Gaps = 18/273 (6%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T +Y++GRT+G+G FA VK A+K+I K K + + I+ E+S ++ Sbjct: 16 TITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRR 73 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 +KHPN++ + E M T++Y V+E V GG+LFD I+S + E +A L +A+ Y Sbjct: 74 VKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYL 133 Query: 146 HSRGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 HS + HRD+KPENLL+ D + +LK+ DFGL+ + DG L+T CGTP YVAPE Sbjct: 134 HSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-----DGPLYTVCGTPTYVAPE 188 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCP----PWF 255 +I GY G K D+W+ GVI ++L+ G+ PF + L+ +I + P Sbjct: 189 IIAETGY-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNV 247 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 S SAK+LI +L + R + +V+E+ W Sbjct: 248 SDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >4PDS-A nrPDB Length = 347 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 90/307 (29%), Positives = 154/307 (50%), Gaps = 24/307 (7%) Query: 2 ASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELG-RTLGEGTFAKVKFARNVENGDNVAIK 60 + + + + ST S + + + +G+G FA VK A G ++K Sbjct: 3 MATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVK 62 Query: 61 VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI 120 +I K KV+ N + + RE+ ++ + HP ++R+ Y V+EFV+GG+L D + Sbjct: 63 IISKRKVIGN--MDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFV 120 Query: 121 SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSAL 178 +++G + ED R+ +Q++ A+ Y HS G+ HRDLKP+N+L++ + +K++ FGL+ + Sbjct: 121 AAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKV 180 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGY------------DGAKADLWSCGVILFVLM 226 + T CGT YVAPEVI K + D+WS G +++V++ Sbjct: 181 Q---GNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVIL 237 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSASAKKLIKRILDPNPATRITFAEVIE 282 G+LPF S LYK+I + + P S A+ I +L +P R T A+ + Sbjct: 238 TGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALN 297 Query: 283 NEWFKKG 289 + W K Sbjct: 298 HPWIKMS 304 >2YCR-A nrPDB Length = 323 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 106/313 (33%), Positives = 157/313 (50%), Gaps = 20/313 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEK-----VLKNKMIAQIKREISTM 83 +Y + +TLG G +VK A + VAIK+I K K + ++ EI + Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 K + HP +I++ Y VLE + GGELFDK+ N RLKE + YF Q++ AV Sbjct: 70 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 144 YCHSRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 Y H G+ HRDLKPEN+LL + +K++DFG S + + E L+ T CGTP Y+AP Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAP 185 Query: 201 EVINNKGY--DGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFTCPP---- 253 EV+ + G D WS GVILF+ ++GY PF E SL +I ++ P Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSG 313 S A L+K++L +P R T E + + W + KF++ +S ++ Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDL-LSEENESTAKPQVL 304 Query: 314 ESKNLVVERREEG 326 + +R EG Sbjct: 305 AQPSTSRKRPREG 317 >3TAC-A nrPDB Length = 361 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 93/290 (32%), Positives = 151/290 (52%), Gaps = 18/290 (6%) Query: 16 TPSGSSSGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI- 73 P GS + YEL +G+G F+ V+ N E G A+K++D K + + Sbjct: 12 VPRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS 71 Query: 74 -AQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN----GRLKE 128 +KRE S ++KHP+++ + E +S +Y V EF+ G +L +I E Sbjct: 72 TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE 131 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL---DANGALKVSDFGLSALPQQVRED 185 A Y +Q++ A+ YCH + HRD+KP +LL + + +K+ FG++ Q Sbjct: 132 AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAI--QLGESG 189 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF 245 + GTP+++APEV+ + Y G D+W CGVILF+L++G LPF + L++ I Sbjct: 190 LVAGGRVGTPHFMAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGII 247 Query: 246 KAEFTCPP----WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 K ++ P S SAK L++R+L +PA RIT E + + W K+ + Sbjct: 248 KGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDR 297 >3COM-A nrPDB Length = 314 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 74/263 (28%), Positives = 125/263 (47%), Gaps = 12/263 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ LGEG++ V A + E G VAIK + E + +I +EIS M+ P+ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES-----DLQEIIKEISIMQQCDSPH 85 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRG 149 V++ + T ++ V+E+ G + D I N L EDE Q + ++Y H Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 145 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HRD+K N+LL+ G K++DFG++ +T GTP ++APEVI GY+ Sbjct: 146 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM--AKRNTVIGTPFWMAPEVIQEIGYN 203 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE---FTCPPWFSASAKKLIKRI 266 AD+WS G+ + G P+ D + I F P +S + +K+ Sbjct: 204 CV-ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 262 Query: 267 LDPNPATRITFAEVIENEWFKKG 289 L +P R T +++++ + + Sbjct: 263 LVKSPEQRATATQLLQHPFVRSA 285 >4CSV-A nrPDB Length = 275 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 118/268 (44%), Gaps = 10/268 (3%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G + L R LG G F +V + VA+K + + + + + + Sbjct: 1 GPHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQ 56 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQ 136 E MK +KHPN+++++ V + IY + E+++ G L D + + Sbjct: 57 EAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 Q+ + + Y S+ HRDL N L+ N +KV+DFGL+ L + Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKF-PIK 175 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPW 254 + APE I+ + K+D+W+ G++L+ + G +P+ + + + +++ + P Sbjct: 176 WTAPEAISYNRF-SIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG 234 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIE 282 +L+ + + +P R TFAE + Sbjct: 235 CPEEIYELMLQCWNKSPEERPTFAETLH 262 >3ORZ-A nrPDB Length = 316 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 141/266 (53%), Gaps = 7/266 (2%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++ G+ LGEG+F+ V AR + AIK+++K ++K + + RE M + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 P ++++ K+YF L + GEL I G E R Y ++++A++Y H + Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 G+ HRDLKPEN+LL+ + ++++DFG + + + ++ GT YV+PE++ K Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS- 215 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 +DLW+ G I++ L+AG PF N +++KI K E+ P F A+ L++++L Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 275 Query: 269 PNPATRITFAE------VIENEWFKK 288 + R+ E + + +F+ Sbjct: 276 LDATKRLGCEEMEGYGPLKAHPFFES 301 >4JG6-A nrPDB Length = 355 Score = 278 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 95/313 (30%), Positives = 157/313 (50%), Gaps = 25/313 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 89 YE+ +G G+++ K + A+K+IDK K + EI + + +HP Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQHP 89 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 N+I + +V +Y V E + GGEL DKI E EA + V+Y H++G Sbjct: 90 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 149 Query: 150 VYHRDLKPENLL-LDANGA---LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 V HRDLKP N+L +D +G +++ DFG + + E+GLL T C T N+VAPEV+ Sbjct: 150 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRA--ENGLLMTPCYTANFVAPEVLER 207 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIFKAEFTCP----PWFSAS 258 +GYD A D+WS GV+L+ ++ GY PF D + +I +F+ S + Sbjct: 208 QGYD-AACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDT 266 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNL 318 AK L+ ++L +P R+T A V+ + W + P+++ ++ D + + + Sbjct: 267 AKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQ---LNRQDAPHLVKGAMAATYS 323 Query: 319 VVERREEGLKTPV 331 + R + + PV Sbjct: 324 ALNRNQSPVLEPV 336 >2BPM-A nrPDB Length = 309 Score = 278 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 132/296 (44%), Gaps = 35/296 (11%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + ++ +GEGT+ V ARN G+ VA+K I + + I REIS +K + Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELN 64 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYC 145 HPN++++ +V+ ++ K+Y V EF+ +L + ++ + + Y QL+ + +C Sbjct: 65 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 123 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS V HRDLKP+NLL++ GA+K++DFGL+ T Y APE++ Sbjct: 124 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLG 181 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK------------------A 247 Y D+WS G I ++ F + +IF+ Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 241 Query: 248 EFTCPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + + P W + L+ ++L +P RI+ + + +F+ K Sbjct: 242 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >2J90-A nrPDB Length = 304 Score = 277 bits (710), Expect = 5e-75, Method: Composition-based stats. Identities = 91/270 (33%), Positives = 149/270 (55%), Gaps = 15/270 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKL 85 YE+G LG G FA V+ R G A K I K ++ ++ +I+RE++ ++ Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 I+HPN+I + ++ +KT + +LE V+GGELFD ++ L EDEA ++ +Q+++ V Y Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 146 HSRGVYHRDLKPENLLL----DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 HS+ + H DLKPEN++L N +K+ DFG++ ++ GTP +VAPE Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIA---HKIEAGNEFKNIFGTPEFVAPE 202 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SA 257 ++N + G +AD+WS GVI ++L++G PF I + + S Sbjct: 203 IVNYEP-LGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 261 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFK 287 AK I+R+L +P R+T A+ +E+ W K Sbjct: 262 LAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >2W4O-A nrPDB Length = 349 Score = 277 bits (709), Expect = 7e-75, Method: Composition-based stats. Identities = 95/285 (33%), Positives = 152/285 (53%), Gaps = 19/285 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+ LG G + V + A+KV+ K K ++ EI + + HPN Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGVLLRLSHPN 109 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 +I++ E+ + T+I VLE VTGGELFD+I G E +A +Q++ AV Y H G+ Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 151 YHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDLKPENLL + LK++DFGLS + V L+ T CGTP Y APE++ Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKI---VEHQVLMKTVCGTPGYCAPEILRGCA 226 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTS-LYKKIFKAEFTC-PPWFSA---SAKKL 262 Y G + D+WS G+I ++L+ G+ PF D ++++I E+ PW+ +AK L Sbjct: 227 Y-GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL 285 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDA 307 +++++ +P R+T + +++ W KA F + D + + Sbjct: 286 VRKLIVLDPKKRLTTFQALQHPWVT--GKAANFVHMDTAQKKLQE 328 >3I6U-A nrPDB Length = 419 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 101/287 (35%), Positives = 148/287 (51%), Gaps = 19/287 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEK-----VLKNKMIAQIKREISTM 83 +Y + +TLG G +VK A + VAI++I K K + ++ EI + Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 K + HP +I++ Y VLE + GGELFDK+ N RLKE + YF Q++ AV Sbjct: 195 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 144 YCHSRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 Y H G+ HRDLKPEN+LL + +K++DFG S + + E L+ T CGTP Y+AP Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAP 310 Query: 201 EVINNKGY--DGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFTCPP---- 253 EV+ + G D WS GVILF+ ++GY PF E SL +I ++ P Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADV 300 S A L+K++L +P R T E + + W + KF++ Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLS 417 >4AF3-A nrPDB Length = 292 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 91/275 (33%), Positives = 151/275 (54%), Gaps = 5/275 (1%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + +E+GR LG+G F V AR ++ VA+KV+ K ++ K + Q++REI + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++R++ + +IY +LE+ GEL+ ++ + E ++L +A+ YCH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + V HRD+KPENLLL G LK++DFG S +R T CGT +Y+ PE+I + Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRR----KTMCGTLDYLPPEMIEGRM 197 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 ++ K DLW GV+ + L+ G PFE ++ Y++I K + P A+ LI ++L Sbjct: 198 HN-EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 268 DPNPATRITFAEVIENEWFKKGYKAPKFENADVSL 302 NP+ R+ A+V + W + + +A S+ Sbjct: 257 RHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSV 291 >5YV8-A nrPDB Length = 298 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 97/300 (32%), Positives = 156/300 (52%), Gaps = 32/300 (10%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK-------- 69 S SSG ++ +Y L +G+G++ VK A N + A+KV+ K+K+++ Sbjct: 2 SSGSSGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRP 61 Query: 70 ---------------NKMIAQIKREISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVT 112 I Q+ +EI+ +K + HPNV+++ EV+ + +Y V E V Sbjct: 62 PPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVN 121 Query: 113 GGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSD 172 G + + + + L ED+AR YFQ LI ++Y H + + HRD+KP NLL+ +G +K++D Sbjct: 122 QGPVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIAD 180 Query: 173 FGLSALPQQVREDGLLHTTCGTPNYVAPEVINN--KGYDGAKADLWSCGVILFVLMAGYL 230 FG+S + D LL T GTP ++APE ++ K + G D+W+ GV L+ + G Sbjct: 181 FGVSNEFK--GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQC 238 Query: 231 PFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 PF D + L+ KI P P + K LI R+LD NP +RI E+ + W + Sbjct: 239 PFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >6E9W-A nrPDB Length = 443 Score = 274 bits (701), Expect = 6e-74, Method: Composition-based stats. Identities = 93/314 (29%), Positives = 151/314 (48%), Gaps = 24/314 (7%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + YE+ + +G G F +V+ R+ A+K++ K +++K A E M Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 P V+++F +Y V+E++ GG+L + + SN + E AR Y +++ A+D Sbjct: 158 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDA 216 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS G HRD+KP+N+LLD +G LK++DFG + T GTP+Y++PEV+ Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGM-VRCDTAVGTPDYISPEVLK 275 Query: 205 ---NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPP--WFSA 257 GY G + D WS GV L+ ++ G PF +L Y KI + T P S Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 258 SAKKLIKRILDPNPATRI---TFAEVIENEWFK---------KGYKAPKFEN--ADVSLD 303 AK LI L + R+ E+ + +FK + AP + +D+ Sbjct: 336 EAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTS 394 Query: 304 DVDAIFDDSGESKN 317 + D + +D GE + Sbjct: 395 NFDDLEEDKGEEET 408 >4LG4-A nrPDB Length = 299 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 127/278 (45%), Gaps = 12/278 (4%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G S + +++ LGEG++ V A + E+G VAIK + E + +I + Sbjct: 1 GEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIK 55 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQ 137 EIS M+ P V++ + T ++ V+E+ G + D I N L EDE + Sbjct: 56 EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS 115 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + ++Y H HR++K N+LL+ G K++DFG++ +T GTP + Sbjct: 116 TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTM--AKRNTVIGTPFW 173 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE---FTCPPW 254 +APEVI GY+ AD+WS G+ + G P+ D + I F P Sbjct: 174 MAPEVIQEIGYNCV-ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 232 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 +S +K+ L NP R T +++++ + K Sbjct: 233 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPV 270 >1PHK-A nrPDB Length = 298 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 85/293 (29%), Positives = 138/293 (47%), Gaps = 21/293 (7%) Query: 13 SRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK--- 69 + P S+ G YE LG G + V+ + A+K+ID Sbjct: 3 DAALPGSHSTHGFYE--NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSA 60 Query: 70 ---NKMIAQIKREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR 125 ++ +E+ ++ + HPN+I++ + + T + V + + GELFD ++ Sbjct: 61 EEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVT 120 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 L E E RK + L+ + H + HRDLKPEN+LLD + +K++DFG S Q+ Sbjct: 121 LSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSC---QLDPG 177 Query: 186 GLLHTTCGTPNYVAPEVIN-----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 L CGTP+Y+APE+I N G + D+WS GVI++ L+AG PF + Sbjct: 178 EKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLM 237 Query: 241 YKKIFKAEFTC--PPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + I + P W +S + K L+ R L P R T E + + +F++ Sbjct: 238 LRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQY 290 >3PFQ-A nrPDB Length = 674 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 149/295 (50%), Gaps = 11/295 (3%) Query: 1 MASRTTPSRSTPSRSTPSGSSSGGRTRVG--KYELGRTLGEGTFAKVKFARNVENGDNVA 58 + T + + ++G R R+ + LG+G+F KV + + A Sbjct: 311 IGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYA 370 Query: 59 IKVIDKEKVLKNKMIAQIKREISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 +K++ K+ V+++ + E + L K P + ++ + ++YFV+E+V GG+L Sbjct: 371 VKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM 430 Query: 118 DKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA 177 I GR KE A Y ++ + + S+G+ +RDLK +N++LD+ G +K++DFG+ Sbjct: 431 YHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK 490 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL 237 + + + T CGTP+Y+APE+I + Y G D W+ GV+L+ ++AG PFE + Sbjct: 491 --ENIWDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDE 547 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITF-----AEVIENEWFK 287 L++ I + P S A + K ++ +P R+ ++ E+ +F+ Sbjct: 548 DELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 602 >6ED6-A nrPDB Length = 415 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 93/318 (29%), Positives = 160/318 (50%), Gaps = 28/318 (8%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G + + Y++ + +G G F +V+ R+ + A+K++ K +++K A E Sbjct: 82 GLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI 141 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 M P V+++F +Y V+E++ GG+L + + SN + E A+ Y +++ A+ Sbjct: 142 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLAL 200 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH--TTCGTPNYVAP 200 D HS G+ HRD+KP+N+LLD +G LK++DFG ++ E G++H T GTP+Y++P Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC---MKMDETGMVHCDTAVGTPDYISP 257 Query: 201 EVIN---NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE----FTCPP 253 EV+ G+ G + D WS GV L+ ++ G PF +L Y KI + F Sbjct: 258 EVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDA 317 Query: 254 WFSASAKKLIKRILDPNPATRI---TFAEVIENEWFK---------KGYKAPKFE--NAD 299 S AK LI L + R+ E+ ++ +FK + AP ++D Sbjct: 318 EISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSD 376 Query: 300 VSLDDVDAIFDDSGESKN 317 + + D I DD G+ + Sbjct: 377 IDSSNFDDIEDDKGDVET 394 >1CM8-A nrPDB Length = 367 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 91/345 (26%), Positives = 144/345 (41%), Gaps = 56/345 (16%) Query: 15 STPSGSSSGGRTRVGK--------YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEK 66 S P S R V K Y + +G G + V A + G VAIK + + Sbjct: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-P 61 Query: 67 VLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKI 120 + RE+ +K ++H NVI + +V T Y V+ F+ G +L K+ Sbjct: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKL 119 Query: 121 SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 + +L ED + Q++ + Y H+ G+ HRDLKP NL ++ + LK+ DFGL+ Sbjct: 120 MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--- 176 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 + D + T Y APEVI N D+WS G I+ ++ G F+ S+ Sbjct: 177 --QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 Query: 241 YKKIFKAEFTCPPWF-------------------------------SASAKKLIKRILDP 269 K+I K T P F S A L++++L Sbjct: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 Query: 270 NPATRITFAEVIENEWFKKGY---KAPKFENADVSLDDVDAIFDD 311 + R+T E + + +F+ + P+ + D S DDVD D+ Sbjct: 295 DAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDE 339 >2Y7J-A nrPDB Length = 365 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 84/292 (28%), Positives = 146/292 (50%), Gaps = 20/292 (6%) Query: 12 PSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI-----DKEK 66 P P +++ + KY+ +G G + V+ + G A+K++ Sbjct: 79 PEDELPDWAAAKEFYQ--KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSP 136 Query: 67 VLKNKMIAQIKREISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR 125 ++ +RE ++ + HP++I + + S + ++ V + + GELFD ++ Sbjct: 137 EQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA 196 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 L E E R + L+ AV + H+ + HRDLKPEN+LLD N +++SDFG S + Sbjct: 197 LSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSC---HLEPG 253 Query: 186 GLLHTTCGTPNYVAPEVIN-----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL 240 L CGTP Y+APE++ G + DLW+CGVILF L+AG PF + Sbjct: 254 EKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILM 313 Query: 241 YKKIFKAEFTC--PPWF--SASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 + I + ++ P W S++ K LI R+L +P R+T + +++ +F++ Sbjct: 314 LRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >4C0T-A nrPDB Length = 974 Score = 271 bits (692), Expect = 6e-73, Method: Composition-based stats. Identities = 95/318 (29%), Positives = 164/318 (51%), Gaps = 10/318 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R V ++ G+ LGEG+++ V A + G A+KV+DK ++K K + + E + Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 85 LIKHP-NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 + + VI ++ K +YFVL++ + GEL I L E+ R + Q+++A+ Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE-------DGLLHTTCGTPN 196 Y H GV HRDLKPEN+LLD ++++DFG + L ++ + D + GT Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFS 256 YV+PE++ NK Y G D+W+ G I++ ++AG PF+ +N ++KI K +F F Sbjct: 442 YVSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFP 500 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESK 316 + LIK+IL P+ R T E+ ++ +F+ F++ +S + + +S Sbjct: 501 TIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFK-DFDSIWLSDPPEIGPYKMTAKSM 559 Query: 317 NLVVERREEGLKTPVTMN 334 V E + + T + N Sbjct: 560 MKVPELNKAPITTVIKKN 577 >5DYK-A nrPDB Length = 853 Score = 270 bits (691), Expect = 9e-73, Method: Composition-based stats. Identities = 92/306 (30%), Positives = 147/306 (48%), Gaps = 23/306 (7%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 + + + E R +G GTF VK + A+K + K ++ IK Sbjct: 528 RIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIK 587 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E HP +IR+ YF+ E VTGGEL+D I G L + +A+ Y Sbjct: 588 LEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGS 647 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +I A++Y H R + +RDLKPEN+LLD G +K+ DFG + Q G +T GTP+Y Sbjct: 648 IILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ-----GRAYTLVGTPHY 702 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWF 255 +APEVI KGY G D+W+ G+ L+ + G LPF ++ + +++ I + T P + Sbjct: 703 MAPEVILGKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYV 761 Query: 256 SA-SAKKLIKRILDPNPATRI-----TFAEVIENEWFK---------KGYKAPKFENADV 300 + + L+KR+L P RI F ++ ++ +F + P ++ Sbjct: 762 TDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSET 821 Query: 301 SLDDVD 306 +D+D Sbjct: 822 YAEDID 827 >6AO5-A nrPDB Length = 362 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 74/266 (27%), Positives = 124/266 (46%), Gaps = 12/266 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +++ LGEG++ V A + E+G VAIK + E + +I +EIS M+ P Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIKEISIMQQCDSPY 66 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRG 149 V++ + T ++ V+E+ G + D I N L EDE + + ++Y H Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HR++K N+LL+ G K++DFG++ +T GTP ++APEVI GY+ Sbjct: 127 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTM--AKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE---FTCPPWFSASAKKLIKRI 266 AD+WS G+ + G P+ D + I F P +S +K+ Sbjct: 185 CV-ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 243 Query: 267 LDPNPATRITFAEVIENEWFKKGYKA 292 L NP R T +++++ + K Sbjct: 244 LVKNPEQRATATQLLQHPFIKNAKPV 269 >3GUB-A nrPDB Length = 295 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 96/286 (33%), Positives = 147/286 (51%), Gaps = 24/286 (8%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y+ G LG G FA VK R G A K I K + ++ I+RE+S +K I+ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPNVI + EV +KT + + E V GGELFD ++ L E+EA ++ +Q++N V Y HS Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 148 RGVYHRDLKPENLLLDANG----ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + H DLKPEN++L +K+ DFGL+ ++ GTP +VAPE++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA---HKIDFGNEFKNIFGTPEFVAPEIV 189 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASA 259 N + G +AD+WS GVI ++L++G PF + + + SA A Sbjct: 190 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK---------GYKAPKFE 296 K I+R+L +P R+T + +++ W K + P+FE Sbjct: 249 KDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAWSHPQFE 294 >2I0E-A nrPDB Length = 353 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 142/269 (52%), Gaps = 9/269 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R ++ + LG+G+F KV + + A+K++ K+ V+++ + E + Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 85 LI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 L K P + ++ + ++YFV+E+V GG+L I GR KE A Y ++ + Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + S+G+ +RDLK +N++LD+ G +K++DFG+ + + + T CGTP+Y+APE+I Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK--ENIWDGVTTKTFCGTPDYIAPEII 193 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 + Y G D W+ GV+L+ ++AG PFE + L++ I + P S A + Sbjct: 194 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 264 KRILDPNPATRITF-----AEVIENEWFK 287 K ++ +P R+ ++ E+ +F+ Sbjct: 253 KGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 >5FET-A nrPDB Length = 847 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 92/277 (33%), Positives = 138/277 (49%), Gaps = 14/277 (5%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 + + + E R +G GTF VK + A+K + K ++ IK Sbjct: 522 RIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIK 581 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 E HP +IR+ YF+ E VTGGEL+D I G L + +A+ Y Sbjct: 582 LEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGS 641 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +I A++Y H R + +RDLKPEN+LLD G +K+ DFG + Q G +T GTP+Y Sbjct: 642 IILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ-----GRAYTLVGTPHY 696 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCPPWF 255 +APEVI KGY G D+W+ GV L+ + G LPF + + +++ I + T P + Sbjct: 697 MAPEVILGKGY-GCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYV 755 Query: 256 S-ASAKKLIKRILDPNPATRI-----TFAEVIENEWF 286 S + L+KR+L P RI F ++ E+ +F Sbjct: 756 SDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2BRG-A nrPDB Length = 297 Score = 269 bits (689), Expect = 2e-72, Method: Composition-based stats. Identities = 99/283 (34%), Positives = 161/283 (56%), Gaps = 9/283 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 V ++L +TLGEG + +V+ A N + VA+K++D ++ + IK+EI K++ Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC--PENIKKEICINKMLN 63 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NV++ + Y LE+ +GGELFD+I + + E +A+++F QL+ V Y H Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 G+ HRD+KPENLLLD LK+SDFGL+ + + + LL+ CGT YVAPE++ + Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLYKKIFKAEFTCPPW--FSASAKKLIK 264 + D+WSCG++L ++AG LP++ S+ Y + + PW ++ L+ Sbjct: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243 Query: 265 RILDPNPATRITFAEVIENEW----FKKGYKAPKFENADVSLD 303 +IL NP+ RIT ++ ++ W KKG K P+ + VS Sbjct: 244 KILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSES 286 >6FD3-A nrPDB Length = 300 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 75/262 (28%), Positives = 133/262 (50%), Gaps = 10/262 (3%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 KY +G+G V A ++ G VAIK ++ ++ K ++ I EI M+ K+ Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKN 78 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++ + +++ V+E++ GG L D ++ + E + ++ + A+D+ HS Sbjct: 79 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN 137 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 V HRD+K +N+LL +G++K++DFG A Q E T GTP ++APEV+ K Y Sbjct: 138 QVIHRDIKSDNILLGMDGSVKLTDFGFCA--QITPEQSKRSTMVGTPYWMAPEVVTRKAY 195 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI---FKAEFTCPPWFSASAKKLIKR 265 G K D+WS G++ ++ G P+ + N I E P SA + + R Sbjct: 196 -GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 254 Query: 266 ILDPNPATRITFAEVIENEWFK 287 L+ + R + E++++ + K Sbjct: 255 CLEMDVDRRGSAKELLQHPFLK 276 >1VZO-A nrPDB Length = 355 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 87/277 (31%), Positives = 152/277 (54%), Gaps = 18/277 (6%) Query: 28 VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKEKVL-KNKMIAQIKREISTM 83 + +EL + LG G + KV R + + G A+KV+ K ++ K K + E + Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 84 KLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 + I+ P ++ + ++TK++ +L+++ GGELF +S R E E + Y +++ A+ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 ++ H G+ +RD+K EN+LLD+NG + ++DFGLS E + CGT Y+AP++ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVA-DETERAYDFCGTIEYMAPDI 231 Query: 203 INN--KGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFS 256 + G+D A D WS GV+++ L+ G PF E ++ + ++I K+E P S Sbjct: 232 VRGGDSGHDKA-VDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 290 Query: 257 ASAKKLIKRILDPNPATRIT-----FAEVIENEWFKK 288 A AK LI+R+L +P R+ E+ E+ +F+K Sbjct: 291 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >3DAK-A nrPDB Length = 290 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 132/282 (46%), Gaps = 23/282 (8%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 YEL +G G A V+ A + VAIK I+ EK + + ++ +EI M H Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQAMSQCHH 67 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKI--------SSNGRLKEDEARKYFQQLIN 140 PN++ + K +++ V++ ++GG + D I +G L E ++++ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP---QQVREDGLLHTTCGTPNY 197 ++Y H G HRD+K N+LL +G+++++DFG+SA + + + T GTP + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP---- 253 +APEV+ KAD+WS G+ L G P+ + + + Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ 247 Query: 254 ------WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + S +K+I L +P R T AE++ +++F+K Sbjct: 248 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 289 >4QMW-A nrPDB Length = 310 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 73/282 (25%), Positives = 131/282 (46%), Gaps = 10/282 (3%) Query: 18 SGSSSGGRTRVGK---YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 SG + + +G+G+F +V + VAIK+ID E+ Sbjct: 15 SGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI 74 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 Q +EI+ + P V + + TK++ ++E++ GG D + G L E + Sbjct: 75 Q--QEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATI 131 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 ++++ +DY HS HRD+K N+LL +G +K++DFG++ + +T GT Sbjct: 132 LREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQ--IKRNTFVGT 189 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP- 253 P ++APEVI YD KAD+WS G+ L G P + + + I K Sbjct: 190 PFWMAPEVIKQSAYDS-KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG 248 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +S K+ ++ L+ P+ R T E++++++ + K + Sbjct: 249 NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSY 290 >4XEY-B nrPDB Length = 408 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 136/307 (44%), Gaps = 27/307 (8%) Query: 5 TTPSRSTPSRSTPSGSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNV 57 TT P R+ P+ G K+E+ R LG G + +V + V Sbjct: 96 TTLHYPAPKRNKPTVY--GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTV 153 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K + ++ + + + +E + MK IKHPN++++ V + Y + EF+T G L Sbjct: 154 AVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 209 Query: 118 DKISSNGRLKEDEA--RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 D + R + + Q+ +A++Y + HRDL N L+ N +KV+DFGL Sbjct: 210 DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 269 Query: 176 SALPQQVREDGLLHTTCG---TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLP 231 S L G + APE + + K+D+W+ GV+L+ + G P Sbjct: 270 SRLM----TGDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGMSP 324 Query: 232 FEDSNLTSLYKKIFK-AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 + +L+ +Y+ + K P +L++ NP+ R +FAE+ ++ F+ + Sbjct: 325 YPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMF 382 Query: 291 KAPKFEN 297 + + Sbjct: 383 QESSISD 389 >3IS5-A nrPDB Length = 285 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 90/270 (33%), Positives = 139/270 (51%), Gaps = 19/270 (7%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + R LG G F V +G IK I+K++ + QI+ EI +K + HPN Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDR--SQVPMEQIEAEIEVLKSLDHPN 81 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLINAVDYCH 146 +I++FEV +Y V+E GGEL ++I L E + +Q++NA+ Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 147 SRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S+ V H+DLKPEN+L + +K+ DFGL+ L + D GT Y+APEV Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAEL---FKSDEHSTNAAGTALYMAPEVF 198 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT----CPPWFSASA 259 K D+WS GV+++ L+ G LPF ++L + +K E C P + A Sbjct: 199 KRDV--TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRP-LTPQA 255 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKG 289 L+K++L +P R + A+V+ +EWFK+ Sbjct: 256 VDLLKQMLTKDPERRPSAAQVLHHEWFKQA 285 >2FO0-A nrPDB Length = 495 Score = 267 bits (684), Expect = 5e-72, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 136/307 (44%), Gaps = 27/307 (8%) Query: 5 TTPSRSTPSRSTPSGSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNV 57 TT P R+ P+ G K+E+ R LG G + +V + V Sbjct: 188 TTLHYPAPKRNKPTVY--GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTV 245 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K + ++ + + + +E + MK IKHPN++++ V + Y + EF+T G L Sbjct: 246 AVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 301 Query: 118 DKISSNGRLKEDEA--RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 D + R + + Q+ +A++Y + HR+L N L+ N +KV+DFGL Sbjct: 302 DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGL 361 Query: 176 SALPQQVREDGLLHTTCG---TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLP 231 S L G + APE + + K+D+W+ GV+L+ + G P Sbjct: 362 SRLM----TGDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGMSP 416 Query: 232 FEDSNLTSLYKKIFK-AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 + +L+ +Y+ + K P +L++ NP+ R +FAE+ ++ F+ + Sbjct: 417 YPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMF 474 Query: 291 KAPKFEN 297 + + Sbjct: 475 QESSISD 481 >2YAB-A nrPDB Length = 361 Score = 267 bits (683), Expect = 6e-72, Method: Composition-based stats. Identities = 86/269 (31%), Positives = 142/269 (52%), Gaps = 15/269 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN+I + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPENLLLDANG----ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + + H DLKPEN++L +K+ DFGL+ ++ + GTP +VAPE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA---HEIEDGVEFKNIFGTPEFVAPEIV 190 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASA 259 N + G +AD+WS GVI ++L++G PF I + F S A Sbjct: 191 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELA 249 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK 288 K I+++L R+T E + + W Sbjct: 250 KDFIRKLLVKETRKRLTIQEALRHPWITP 278 >5J5T-A nrPDB Length = 370 Score = 267 bits (682), Expect = 9e-72, Method: Composition-based stats. Identities = 90/297 (30%), Positives = 134/297 (45%), Gaps = 23/297 (7%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +EL + +G GT+ V ARNV G+ AIKVI E + A +++EI MK KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE---PGEDFAVVQQEIIMMKDCKH 60 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++ F + K++ +EF GG L D G L E + ++ + + Y HS+ Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV--INNK 206 G HRD+K N+LL NG +K++DFG+SA GTP ++APEV + K Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATI--AKRKAFIGTPYWMAPEVAAVERK 178 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP-----WFSASAKK 261 G DLW+ G+ L P D + + K+ F P +S S Sbjct: 179 GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHH 238 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKA-------PKFENADVS----LDDVDA 307 +K L NP R T +++++ + + K N D S DD D Sbjct: 239 FVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDP 295 >4AGU-A nrPDB Length = 311 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 119/291 (40%), Gaps = 34/291 (11%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + KYE +GEG++ V RN + G VAIK E + REI +K +K Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLK 60 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 HPN++ + EV K +++ V E+ L + + E + Q + AV++CH Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRD+KPEN+L+ + +K+ DFG + L T Y +PE++ Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLL--TGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 208 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK--------------------- 246 G D+W+ G + L++G + + I K Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSG 238 Query: 247 AEFTCP----------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + P P S A L+K L +P R+T +++ + +F+ Sbjct: 239 VKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >5LOH-A nrPDB Length = 341 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 136/269 (50%), Gaps = 10/269 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + ++ + + + G F KV + + G A+KV+ K ++ M Q++ E + Sbjct: 32 PPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALA 89 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 L K P ++ ++ + S +Y V+E++ GG++ + G E+ A KY ++ A+DY Sbjct: 90 LSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDY 149 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL----PQQVREDGLLHTTCGTPNYVAP 200 H G+ HRDLKP+N+L+ G +K++DFGLS + + + T CGTP+Y+AP Sbjct: 150 LHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP---PWFSA 257 E++ + + G D W+ GV LF + G PF D +++ I K + P S Sbjct: 210 ELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSD 268 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWF 286 +A+ ++ +L + R E+ + F Sbjct: 269 NAQSAVEILLTIDDTKRAGMKELKRHPLF 297 >3NIZ-A nrPDB Length = 311 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 127/295 (43%), Gaps = 36/295 (12%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + KY+ +GEGT+ V A++ G VA+K I + + + REIS +K + Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLD-AEDEGIPSTAIREISLLKELH 77 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCH 146 HPN++ + +V+ S+ + V EF+ +L + N L++ + + Y QL+ V +CH Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRDLKP+NLL++++GALK++DFGL+ T Y AP+V+ Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAF--GIPVRSYTHEVVTLWYRAPDVLMGS 194 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA-----EFTCP--------- 252 D+WS G I ++ G F KIF P Sbjct: 195 KKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWK 254 Query: 253 ----------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 P F L+ +L +P RI+ + + + +FK Sbjct: 255 QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDP 309 >2WQN-A nrPDB Length = 310 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 82/263 (31%), Positives = 133/263 (50%), Gaps = 11/263 (4%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 G + + + + +G G F++V A + +G VA+K + ++ K A +EI Sbjct: 24 PDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEI 83 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL---FDKISSNGRL-KEDEARKYFQ 136 +K + HPNVI+ + ++ VLE G+L RL E KYF Sbjct: 84 DLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFV 143 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 QL +A+++ HSR V HRD+KP N+ + A G +K+ D GL + H+ GTP Sbjct: 144 QLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS--KTTAAHSLVGTPY 201 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS--NLTSLYKKIFKAEFTCPP- 253 Y++PE I+ GY+ K+D+WS G +L+ + A PF NL SL KKI + ++ P Sbjct: 202 YMSPERIHENGYN-FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPS 260 Query: 254 -WFSASAKKLIKRILDPNPATRI 275 +S ++L+ ++P+P R Sbjct: 261 DHYSEELRQLVNMCINPDPEKRP 283 >2XIK-A nrPDB Length = 294 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 13/269 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + +G+G+F +V + + VAIK+ID E+ Q +EI+ + P Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 + R F TK++ ++E++ GG D + G L+E ++++ +DY HS Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERK 137 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+K N+LL G +K++DFG++ + +T GTP ++APEVI YD Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ--IKRNTFVGTPFWMAPEVIKQSAYD- 194 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASAKKLIKRI 266 KAD+WS G+ L G P D + + I K PP S K+ ++ Sbjct: 195 FKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK---NSPPTLEGQHSKPFKEFVEAC 251 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKF 295 L+ +P R T E++++++ + K F Sbjct: 252 LNKDPRFRPTAKELLKHKFITRYTKKTSF 280 >4MYG-A nrPDB Length = 372 Score = 264 bits (675), Expect = 7e-71, Method: Composition-based stats. Identities = 85/364 (23%), Positives = 149/364 (40%), Gaps = 68/364 (18%) Query: 16 TPSGSSSGGRTRVGKY---------ELGRT------LGEGTFAKVKFARNVENGDNVAIK 60 P GS + G Y EL +T +G G + V A + +G+ VAIK Sbjct: 15 VPRGSHMSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIK 74 Query: 61 VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKI------YFVLEFVTGG 114 + + + RE+ +K ++H NVI + +V + + Y V+ F+ Sbjct: 75 KLSR-PFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-T 132 Query: 115 ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFG 174 +L + E++ + Q++ + Y HS GV HRDLKP NL ++ + LK+ DFG Sbjct: 133 DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFG 190 Query: 175 LSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED 234 L+ D + T Y APEVI + + D+WS G I+ ++ G F+ Sbjct: 191 LAR-----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKG 245 Query: 235 SNLTSLYKKIFKAEF-------------------------------TCPPWFSASAKKLI 263 + +I K P S A L+ Sbjct: 246 KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLL 305 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERR 323 +++L+ + R+T A+ + + +F+ ++ P+ E + FDDS E + L V+ Sbjct: 306 EKMLELDVDKRLTAAQALTHPFFEP-FRDPEEET------EAQQPFDDSLEHEKLTVDEW 358 Query: 324 EEGL 327 ++ + Sbjct: 359 KQHI 362 >4WNO-A nrPDB Length = 287 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 95/279 (34%), Positives = 150/279 (53%), Gaps = 21/279 (7%) Query: 23 GGRTRVGKYELGRT--LGEGTFAKVKFARNVENGD-NVAIKVIDKEKVLKNKMIAQIKRE 79 GG VGK+E R +G G FA V R+ D VA+K I+K+ + K++ + + +E Sbjct: 10 GGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKE 67 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 I +K +KH N++ +++ +Y V+E+ GG+L D + + L ED R + QQ+ Sbjct: 68 IKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIA 127 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANG---------ALKVSDFGLSALPQQVREDGLLHT 190 A+ HS+G+ HRDLKP+N+LL +K++DFG + Q + + T Sbjct: 128 GAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQS---NMMAAT 184 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL---YKKIFKA 247 CG+P Y+APEVI ++ YDG KADLWS G I++ + G PF+ S+ L Y+K Sbjct: 185 LCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTL 243 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 T P SA ++L+ +L N R+ F E + + Sbjct: 244 VPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >2A27-A nrPDB Length = 321 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 86/269 (31%), Positives = 141/269 (52%), Gaps = 15/269 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NVI + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPENLLLDANG----ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + + H DLKPEN++L +K+ DFGL+ ++ + GTP +VAPE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA---HEIEDGVEFKNIFGTPEFVAPEIV 190 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASA 259 N + G +AD+WS GVI ++L++G PF I + F S A Sbjct: 191 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELA 249 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK 288 K I+++L R+T E + + W Sbjct: 250 KDFIRKLLVKETRKRLTIQEALRHPWITP 278 >1ZWS-A nrPDB Length = 288 Score = 262 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 86/269 (31%), Positives = 141/269 (52%), Gaps = 15/269 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM---IAQIKREISTMKLIK 87 Y++G LG G FA VK R G A K I K + ++ +I+RE+S ++ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 H NVI + +V ++T + +LE V+GGELFD ++ L E+EA + +Q+++ V+Y H+ Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 148 RGVYHRDLKPENLLLDANG----ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 + + H DLKPEN++L +K+ DFGL+ ++ + GTP +VAPE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA---HEIEDGVEFKNIFGTPEFVAPEIV 190 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----SASA 259 N + G +AD+WS GVI ++L++G PF I + F S A Sbjct: 191 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELA 249 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK 288 K I+++L R+T E + + W Sbjct: 250 KDFIRKLLVKETRKRLTIQEALRHPWITP 278 >4IC8-A nrPDB Length = 442 Score = 262 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 83/342 (24%), Positives = 131/342 (38%), Gaps = 48/342 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YE+ T+G G + V AR G VAIK I + + RE+ +K KH Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA-KRTLRELKILKHFKH 113 Query: 89 PNVIRMFEVMASKTK------IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+I + +++ +Y VL+ + +L I S+ L + R + QL+ + Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAP 200 Y HS V HRDLKP NLL++ N LK+ DFG++ + T Y AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----- 255 E++ + DLWS G I ++A F N + I T P Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 256 --------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 A L+ R+L P+ RI+ A + + + K Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 352 Query: 290 YKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPV 331 + D FD + + + L ER +E + + Sbjct: 353 HDPDDEP-------DCAPPFDFAFDREALTRERIKEAIVAEI 387 >3A8W-A nrPDB Length = 345 Score = 262 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 84/274 (30%), Positives = 150/274 (54%), Gaps = 19/274 (6%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-KH 88 ++L R +G G++AKV R + A+KV+ KE V ++ I ++ E + H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 P ++ + ++++++FV+E+V GG+L + +L E+ AR Y ++ A++Y H R Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 G+ +RDLK +N+LLD+ G +K++D+G+ + +R T CGTPNY+APE++ + Y Sbjct: 130 GIIYRDLKLDNVLLDSEGHIKLTDYGMCK--EGLRPGDTTSTFCGTPNYIAPEILRGEDY 187 Query: 209 DGAKADLWSCGVILFVLMAGYLPF--------EDSNLTS-LYKKIFKAEFTCPPWFSASA 259 G D W+ GV++F +MAG PF D N L++ I + + P S A Sbjct: 188 -GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKA 246 Query: 260 KKLIKRILDPNPATRI------TFAEVIENEWFK 287 ++K L+ +P R+ FA++ + +F+ Sbjct: 247 ASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 >3Q53-A nrPDB Length = 306 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 75/262 (28%), Positives = 134/262 (51%), Gaps = 10/262 (3%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 KY +G+G V A +V G VAI+ ++ ++ K ++ I EI M+ K+ Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL---IINEILVMRENKN 77 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 PN++ + +++ V+E++ GG L D ++ + E + ++ + A+++ HS Sbjct: 78 PNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN 136 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 V HRD+K +N+LL +G++K++DFG A Q E T GTP ++APEV+ K Y Sbjct: 137 QVIHRDIKSDNILLGMDGSVKLTDFGFCA--QITPEQSKRSTMVGTPYWMAPEVVTRKAY 194 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI---FKAEFTCPPWFSASAKKLIKR 265 G K D+WS G++ ++ G P+ + N I E P SA + + R Sbjct: 195 -GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR 253 Query: 266 ILDPNPATRITFAEVIENEWFK 287 L+ + R + E+I++++ K Sbjct: 254 CLEMDVEKRGSAKELIQHQFLK 275 >3TKU-A nrPDB Length = 433 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 142/316 (44%), Gaps = 22/316 (6%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + +E+ + +G G F +V + A+K+++K ++LK A + E + Sbjct: 86 QLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV 145 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVD 143 + + + +Y V+++ GG+L +S +L ED AR Y +++ A+D Sbjct: 146 NGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 205 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 H HRD+KP+N+LLD NG ++++DFG S L GTP+Y++PE++ Sbjct: 206 SIHQLHYVHRDIKPDNVLLDVNGHIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 204 N----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCPPW--- 254 G G + D WS GV ++ ++ G PF +L Y KI + F P Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD 324 Query: 255 FSASAKKLIKRILDPNPATRI---TFAEVIENEWFK-------KGYKAPKFENADVSLDD 304 S AK LI+R++ + R+ + ++ +F+ + +AP + D Sbjct: 325 VSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDT 383 Query: 305 VDAIFDDSGESKNLVV 320 + DD ++ Sbjct: 384 SNFDVDDDVLRNTEIL 399 >4ZSG-A nrPDB Length = 347 Score = 261 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 83/342 (24%), Positives = 131/342 (38%), Gaps = 48/342 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YE+ T+G G + V AR G VAIK I + + RE+ +K KH Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNA-KRTLRELKILKHFKH 65 Query: 89 PNVIRMFEVMASKTK------IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+I + +++ +Y VL+ + +L I S+ L + R + QL+ + Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAP 200 Y HS V HRDLKP NLL++ N LK+ DFG++ + T Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF----- 255 E++ + DLWS G I ++A F N + I T P Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 256 --------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 A L+ R+L P+ RI+ A + + + K Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 290 YKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPV 331 + D FD + + + L ER +E + + Sbjct: 305 HDPDDEP-------DCAPPFDFAFDREALTRERIKEAIVAEI 339 >4AW2-A nrPDB Length = 437 Score = 261 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 81/309 (26%), Positives = 145/309 (46%), Gaps = 26/309 (8%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R +E+ + +G G F +V + A+K+++K ++LK A + E + Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVD 143 + + +Y V+++ GG+L +S RL E+ AR Y +++ A+D Sbjct: 130 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 189 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT--CGTPNYVAPE 201 H HRD+KP+N+L+D NG ++++DFG ++ EDG + ++ GTP+Y++PE Sbjct: 190 SVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL---KLMEDGTVQSSVAVGTPDYISPE 246 Query: 202 VIN----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--KAEFTCP--- 252 ++ KG G + D WS GV ++ ++ G PF +L Y KI K F P Sbjct: 247 ILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQV 306 Query: 253 PWFSASAKKLIKRILDPNPATRI---TFAEVIENEWFK-------KGYKAPKFENADVSL 302 S +AK LI+R++ + R+ + ++ +F + +AP Sbjct: 307 TDVSENAKDLIRRLIC-SREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPT 365 Query: 303 DDVDAIFDD 311 D + DD Sbjct: 366 DTSNFDVDD 374 >4FZF-B nrPDB Length = 283 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 73/269 (27%), Positives = 128/269 (47%), Gaps = 13/269 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + +G+G+F +V + VAIK+ID E+ Q +EI+ + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 V + + +K++ ++E++ GG D + + G E + ++++ +DY HS Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+K N+LL G +K++ FG++ + +T GTP ++APEVI YD Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQ--IKRNTFVGTPFWMAPEVIQQSAYDS 184 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSASAKKLIKRI 266 KAD+WS G+ L G P D + + I K PP F+ S K+ I Sbjct: 185 -KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPK---NNPPTLVGDFTKSFKEFIDAC 240 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKF 295 L+ +P+ R T E++++++ K K + Sbjct: 241 LNKDPSFRPTAKELLKHKFIVKNSKKTSY 269 >4AU8-A nrPDB Length = 296 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 85/294 (28%), Positives = 134/294 (45%), Gaps = 35/294 (11%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 KYE +GEGT+ V A+N E + VA+K + + + + REI +K +KH Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHK 65 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSR 148 N++R+ +V+ S K+ V EF +L S NG L + + + QL+ + +CHSR Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 124 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 V HRDLKP+NLL++ NG LK++DFGL+ T Y P+V+ Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKL 182 Query: 209 DGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLYKKIFK-----AEFTCP---------- 252 D+WS G I L AG F +++ K+IF+ E P Sbjct: 183 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 242 Query: 253 --------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 P +A+ + L++ +L NP RI+ E +++ +F Sbjct: 243 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >3OHT-A nrPDB Length = 389 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 140/334 (41%), Gaps = 53/334 (15%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ +G G + V + +V++G +A+K + + + RE+ +K +KH Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 109 Query: 89 PNVIRMFEVMASKTKI------YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 NVI + +V T + Y V + G +L + I +L +D + Q++ + Sbjct: 110 ENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 167 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE+ Sbjct: 168 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEI 222 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------- 255 + N + D+WS G I+ L+ G F ++ + ++I + T P Sbjct: 223 MLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSH 282 Query: 256 ------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + A L++++L + RIT +E + + +F + + Sbjct: 283 EARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHD 342 Query: 292 APKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 ++ +D S ES+ L +E + Sbjct: 343 PDDEPESE--------PYDQSFESRQLEIEEWKR 368 >2UV2-A nrPDB Length = 325 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 136/272 (50%), Gaps = 15/272 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+ LG+G F KV A+N E A KVID + + + EI + HPN Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK---SEEELEDYMVEIDILASCDHPN 95 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDK-ISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++++ + + ++ ++EF GG + + L E + + +Q ++A++Y H Sbjct: 96 IVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNK 155 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN----- 204 + HRDLK N+L +G +K++DFG+SA + R + GTP ++APEV+ Sbjct: 156 IIHRDLKAGNILFTLDGDIKLADFGVSA--KNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---CPPWFSASAKK 261 ++ YD KAD+WS G+ L + P + N + KI K+E P +S++ K Sbjct: 214 DRPYDY-KADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKD 272 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 +K+ L+ N R T ++++++ + P Sbjct: 273 FLKKCLEKNVDARWTTSQLLQHPFVTVDSNKP 304 >3UTO-A nrPDB Length = 573 Score = 261 bits (666), Expect = 6e-70, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 134/292 (45%), Gaps = 14/292 (4%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 P + Y++ LG G F V G+N A K + + Sbjct: 145 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETV 201 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYF 135 ++EI TM +++HP ++ + + ++ + EF++GGELF+K+ + ++ EDEA +Y Sbjct: 202 RKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYM 261 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSALPQQVREDGLLHTTCG 193 +Q+ + + H H DLKPEN++ + LK+ DFGL+A + + T G Sbjct: 262 RQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA---HLDPKQSVKVTTG 318 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 T + APEV K G D+WS GV+ ++L++G PF N + + ++ Sbjct: 319 TAEFAAPEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDD 377 Query: 254 W----FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS 301 S K I+++L +P TR+T + +E+ W G + S Sbjct: 378 SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSS 429 >5DBX-A nrPDB Length = 328 Score = 261 bits (666), Expect = 7e-70, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 134/291 (46%), Gaps = 23/291 (7%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G YEL +G G A V+ A + VAIK I+ EK + + ++ +EI Sbjct: 5 GWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS--MDELLKEIQA 62 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI--------SSNGRLKEDEARKY 134 M HPNV+ + K +++ V++ ++GG + D I NG L+E Sbjct: 63 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 122 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP---QQVREDGLLHTT 191 ++++ +DY H G HRDLK N+LL +G+++++DFG+SA V + + Sbjct: 123 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDF 182 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC 251 GTP ++APEV+ KAD+WS G+ L G P+ + + + Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 242 Query: 252 PP----------WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + S +KL+ L +P+ R T AE+++ ++F+K Sbjct: 243 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNR 293 >4APC-A nrPDB Length = 350 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 77/275 (28%), Positives = 145/275 (52%), Gaps = 11/275 (4%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G+ + + KY + +GEG+F K ++ E+G IK I+ ++ +K + +R Sbjct: 14 GTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRM-SSKEREESRR 72 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQ 136 E++ + +KHPN+++ E +Y V+++ GG+LF +I++ +ED+ +F Sbjct: 73 EVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFV 132 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 Q+ A+ + H R + HRD+K +N+ L +G +++ DFG++ + E L GTP Sbjct: 133 QICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVE--LARACIGTPY 190 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--- 253 Y++PE+ NK Y+ K+D+W+ G +L+ L FE ++ +L KI F PP Sbjct: 191 YLSPEICENKPYNN-KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSF--PPVSL 247 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 +S + L+ ++ NP R + ++E + K Sbjct: 248 HYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 282 >3KN6-A nrPDB Length = 325 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 93/270 (34%), Positives = 150/270 (55%), Gaps = 24/270 (8%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIR 93 + LGEG+F+ + + ++ A+K+I K +M A ++EI+ +KL + HPN+++ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + EV + + V+E + GGELF++I E EA ++L++AV + H GV HR Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 154 DLKPENLLL---DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 DLKPENLL + N +K+ DFG + L ++ L T C T +Y APE++N GYD Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPP--DNQPLKTPCFTLHYAAPELLNQNGYD- 187 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLT-------SLYKKIFKAEFTCP----PWFSASA 259 DLWS GVIL+ +++G +PF+ + + + KKI K +F+ S A Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 247 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKG 289 K LI+ +L +P R+ + + NEW + G Sbjct: 248 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDG 277 >4BBM-A nrPDB Length = 331 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 82/311 (26%), Positives = 132/311 (42%), Gaps = 36/311 (11%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI-K 77 G+ + + KYE +GEG++ V RN + G VAIK + +KM+ +I Sbjct: 15 GTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD--DDKMVKKIAM 72 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 REI +K ++H N++ + EV K + Y V EFV L D L +KY Q Sbjct: 73 REIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQ 132 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 +IN + +CHS + HRD+KPEN+L+ +G +K+ DFG + E + T Y Sbjct: 133 IINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE--VYDDEVATRWY 190 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF------------ 245 APE++ G D+W+ G ++ + G F + I Sbjct: 191 RAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQE 250 Query: 246 --------------KAEFTCP-----PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 + + P P S L K+ L +P R AE++ +++F Sbjct: 251 LFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 Query: 287 KKGYKAPKFEN 297 + A +F Sbjct: 311 QMDGFAERFSQ 321 >6BDL-A nrPDB Length = 347 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 79/269 (29%), Positives = 136/269 (50%), Gaps = 12/269 (4%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNV-ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 ++ + + TLG G F +V+ + E A+K++ K ++ + I+ E M+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 ++R++ +Y ++E GGEL+ + G ++ R Y ++ A Y Sbjct: 92 AHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 HS+G+ +RDLKPENL+LD G K+ DFG + ++ T CGTP YVAPE+I N Sbjct: 152 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAK---KIGFGKKTWTFCGTPEYVAPEIILN 208 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPWFSASAKKLI 263 KG+D AD WS G++++ L+ G PF + Y I + P + +A LI Sbjct: 209 KGHD-ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLI 267 Query: 264 KRILDPNPATRI-----TFAEVIENEWFK 287 K++ NP+ R+ ++ +++WF+ Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFE 296 >6NPU-A nrPDB Length = 298 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 129/288 (44%), Gaps = 25/288 (8%) Query: 24 GRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 G K+E+ R LG G + +V + VA+K + ++ + + + Sbjct: 14 GSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEF 69 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEA--RKY 134 +E + MK IKHPN++++ V + Y + EF+T G L D + R + + Sbjct: 70 LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYM 129 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG- 193 Q+ +A++Y + HRDL N L+ N +KV+DFGLS L G Sbjct: 130 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----TGDTYTAHAGA 185 Query: 194 --TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK-AEF 249 + APE + + K+D+W+ GV+L+ + G P+ +L+ +Y+ + K Sbjct: 186 KFPIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 244 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 P +L++ NP+ R +FAE+ ++ F+ ++ + Sbjct: 245 ERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISD 290 >5Z33-A nrPDB Length = 425 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 143/332 (43%), Gaps = 40/332 (12%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 87 +Y + + LG+G + V A N + + VAIK + K + + REI ++ + Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNV-FSKKILAKRALREIKLLQHFRG 89 Query: 88 HPNVIRMFEVMASK----TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 H N+ ++++ + + Y E + +L I S L + + + Q++ + Sbjct: 90 HRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCGLK 148 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED--GLLHTTCGTPNYVAPE 201 Y HS V HRDLKP NLL++A+ LK+ DFGL+ E+ G + T Y APE Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI----------------- 244 ++ + D+WS G IL L+ G F+ + +I Sbjct: 209 IMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 245 -----------FKAEFTCP---PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 F A+ P P + A L+ R+L +P++RI+ + +E+ + + Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWH 328 Query: 291 KAPKFENADVSLDDVDAIFDDSGESKNLVVER 322 A + + + + +D GE + ++++ Sbjct: 329 DASDEPDCPTTFNFDFEVVEDVGEMRKMILDE 360 >4KRC-A nrPDB Length = 317 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 126/302 (41%), Gaps = 45/302 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +++ LG GT+A V N G VA+K + + + + REIS MK +KH Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN------GRLKEDEARKYFQQLINAV 142 N++R+++V+ ++ K+ V EF+ +L + S L+ + + + QL+ + Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 +CH + HRDLKP+NLL++ G LK+ DFGL+ + T Y AP+V Sbjct: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDV 179 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA--- 259 + D+WSCG IL ++ G F +N K IF T S Sbjct: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 Query: 260 -------------------------------KKLIKRILDPNPATRITFAEVIENEWFKK 288 + +L NP R++ + + + WF + Sbjct: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 Query: 289 GY 290 Y Sbjct: 300 YY 301 >4EWQ-A nrPDB Length = 383 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 136/333 (40%), Gaps = 53/333 (15%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y+ +G G + V A + + G VA+K + + + RE+ +K +KH Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 103 Query: 89 PNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 NVI + +V +Y V + G +L + I +L +D + Q++ + Sbjct: 104 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 161 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y HS + HRDLKP NL ++ + LK+ DFGL+ D + T Y APE+ Sbjct: 162 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEI 216 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------- 255 + N + D+WS G I+ L+ G F ++ K I + T Sbjct: 217 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 276 Query: 256 ------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + A L++++L + RIT A+ + + +F + + Sbjct: 277 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 336 Query: 292 APKFENADVSLDDVDAIFDDSGESKNLVVERRE 324 AD +D S ES++L+++ + Sbjct: 337 PDDEPVAD--------PYDQSFESRDLLIDEWK 361 >1KOA-A nrPDB Length = 491 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 134/292 (45%), Gaps = 14/292 (4%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 P + Y++ LG G F V G+N A K + + Sbjct: 39 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETV 95 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYF 135 ++EI TM +++HP ++ + + ++ + EF++GGELF+K+ + ++ EDEA +Y Sbjct: 96 RKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYM 155 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDA--NGALKVSDFGLSALPQQVREDGLLHTTCG 193 +Q+ + + H H DLKPEN++ + LK+ DFGL+A + + T G Sbjct: 156 RQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTA---HLDPKQSVKVTTG 212 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP 253 T + APEV K G D+WS GV+ ++L++G PF N + + ++ Sbjct: 213 TAEFAAPEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDD 271 Query: 254 W----FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS 301 S K I+++L +P TR+T + +E+ W G + S Sbjct: 272 SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSS 323 >2F57-A nrPDB Length = 317 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 73/258 (28%), Positives = 134/258 (51%), Gaps = 16/258 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V A G VA+K +D K + ++ + E+ M+ H NV+ M+ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL---LFNEVVIMRDYHHDNVVDMY 108 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ Y H++GV HRD+ Sbjct: 109 SSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI 167 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL ++G +K+SDFG A Q +E + GTP ++APEVI+ Y G + D+ Sbjct: 168 KSDSILLTSDGRIKLSDFGFCA--QVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDI 224 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP------WFSASAKKLIKRILDP 269 WS G+++ ++ G P+ + ++I + PP S+ + + +L Sbjct: 225 WSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD---SLPPRVKDLHKVSSVLRGFLDLMLVR 281 Query: 270 NPATRITFAEVIENEWFK 287 P+ R T E++ + + K Sbjct: 282 EPSQRATAQELLGHPFLK 299 >4KS7-A nrPDB Length = 292 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 69/256 (26%), Positives = 135/256 (52%), Gaps = 10/256 (3%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V AR +G VA+K++D K + ++ + E+ M+ +H NV+ M+ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL---LFNEVVIMRDYQHFNVVEMY 86 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 + +++ ++EF+ GG L D I S RL E++ + ++ A+ Y H++GV HRD+ Sbjct: 87 KSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL +G +K+SDFG A + + GTP ++APEVI ++ + D+ Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVP--KRKSLVGTPYWMAPEVI-SRSLYATEVDI 202 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---CPPWFSASAKKLIKRILDPNPA 272 WS G+++ ++ G P+ + K++ + S + ++R+L +P Sbjct: 203 WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQ 262 Query: 273 TRITFAEVIENEWFKK 288 R T E++++ + + Sbjct: 263 ERATAQELLDHPFLLQ 278 >2XYN-A nrPDB Length = 292 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 121/275 (44%), Gaps = 23/275 (8%) Query: 19 GSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK 71 G+ + + K+E+ R LG G + +V + VA+K + ++ + Sbjct: 15 GTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM---- 70 Query: 72 MIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKED 129 + + +E + MK IKHPN++++ V + Y V E++ G L D + R + Sbjct: 71 EVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAV 130 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 Q+ +A++Y + HRDL N L+ N +KV+DFGLS L Sbjct: 131 VLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM----TGDTYT 186 Query: 190 TTCG---TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIF 245 G + APE + + K+D+W+ GV+L+ + G P+ +L+ +Y + Sbjct: 187 AHAGAKFPIKWTAPESLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE 245 Query: 246 KA-EFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 K P +L++ +PA R +FAE Sbjct: 246 KGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 280 >4FIE-A nrPDB Length = 423 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 77/263 (29%), Positives = 136/263 (51%), Gaps = 16/263 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V A +G VA+K +D K + ++ + E+ M+ +H NV+ M+ Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL---LFNEVVIMRDYQHENVVEMY 214 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+ Sbjct: 215 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 273 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+ Sbjct: 274 KSDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDI 330 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP------WFSASAKKLIKRILDP 269 WS G+++ ++ G P+ + K I PP S S K + R+L Sbjct: 331 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVR 387 Query: 270 NPATRITFAEVIENEWFKKGYKA 292 +PA R T AE++++ + K Sbjct: 388 DPAQRATAAELLKHPFLAKAGPP 410 >4JDH-A nrPDB Length = 346 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 77/263 (29%), Positives = 136/263 (51%), Gaps = 16/263 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V A +G VA+K +D K + ++ + E+ M+ +H NV+ M+ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL---LFNEVVIMRDYQHENVVEMY 137 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+ Sbjct: 138 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 196 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+ Sbjct: 197 KSDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDI 253 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP------WFSASAKKLIKRILDP 269 WS G+++ ++ G P+ + K I PP S S K + R+L Sbjct: 254 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVR 310 Query: 270 NPATRITFAEVIENEWFKKGYKA 292 +PA R T AE++++ + K Sbjct: 311 DPAQRATAAELLKHPFLAKAGPP 333 >2Q0N-A nrPDB Length = 301 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 77/263 (29%), Positives = 136/263 (51%), Gaps = 16/263 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V A +G VA+K +D K + ++ + E+ M+ +H NV+ M+ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL---LFNEVVIMRDYQHENVVEMY 92 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+ Sbjct: 93 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 151 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+ Sbjct: 152 KSDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDI 208 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP------WFSASAKKLIKRILDP 269 WS G+++ ++ G P+ + K I PP S S K + R+L Sbjct: 209 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVR 265 Query: 270 NPATRITFAEVIENEWFKKGYKA 292 +PA R T AE++++ + K Sbjct: 266 DPAQRATAAELLKHPFLAKAGPP 288 >6DTL-A nrPDB Length = 364 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 129/323 (39%), Gaps = 42/323 (13%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIRM 94 +G+G + V A N E ++VAIK I NK+ A + REI ++ + H N++ + Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 95 FEVMASK-----TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 +++ +Y E + +L I SN L E+ + + Q++ + Y HS Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 V HRDLKP NLLL+AN LK+ DFGL+ + E + T Y APE++ N Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLARV---TSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF----------------------KA 247 A D+WS G I LM F + + + + Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 248 EFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENAD 299 P P A LI+++L +P RIT + + + + + Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 330 Query: 300 VSLDDVDAIFDDSGESKNLVVER 322 + + S E ++ R Sbjct: 331 IPFNFDFENHALSEEQMKELIYR 353 >6GU6-A nrPDB Length = 302 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 128/296 (43%), Gaps = 36/296 (12%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + Y +GEGT+ V R+ G VA+K I E + + + REIS +K ++ Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 64 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS---NGRLKEDEARKYFQQLINAVDY 144 HPN++ + +V+ +++Y + EF++ +L + S + + Y Q++ + + Sbjct: 65 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 123 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 CHSR V HRDLKP+NLL+D G +K++DFGL+ + T Y +PEV+ Sbjct: 124 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL 181 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA----------------- 247 D+WS G I L F + +IF+A Sbjct: 182 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 241 Query: 248 -EFTCPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 + T P W + L+ ++L +PA RI+ + + +F Sbjct: 242 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 297 >5D7A-A nrPDB Length = 308 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 78/298 (26%), Positives = 130/298 (43%), Gaps = 24/298 (8%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S R G +EL +G GT+ +V R+V+ G AIKV+D + +IK+EI+ Sbjct: 10 SALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEIN 65 Query: 82 TMKL-IKHPNVIRMFEVMASKTK------IYFVLEFVTGGELFDKIS--SNGRLKEDEAR 132 +K H N+ + K ++ V+EF G + D I LKE+ Sbjct: 66 MLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIA 125 Query: 133 KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC 192 ++++ + + H V HRD+K +N+LL N +K+ DFG+SA + G +T Sbjct: 126 YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV--GRRNTFI 183 Query: 193 GTPNYVAPEVINNKGY----DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 GTP ++APEVI K+DLWS G+ + G P D + I + Sbjct: 184 GTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP 243 Query: 249 FTC--PPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDD 304 +S + I+ L N + R +++++ + + P + L D Sbjct: 244 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD---QPNERQVRIQLKD 298 >1JPA-A nrPDB Length = 312 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 62/264 (23%), Positives = 107/264 (40%), Gaps = 12/264 (4%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMK 84 + ++ + +G G F +V G VAIK + K E S M Sbjct: 32 ISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK--SGYTEKQRRDFLSEASIMG 89 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVD 143 HPNVI + V+ T + + EF+ G L + N G+ + + + + Sbjct: 90 QFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMK 149 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAP 200 Y HRDL N+L+++N KVSDFGLS + D + G + AP Sbjct: 150 YLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAP 209 Query: 201 EVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAEFTCPP-WFSAS 258 E I + + A +D+WS G++++ + G P+ D + I + PP ++ Sbjct: 210 EAIQYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSA 268 Query: 259 AKKLIKRILDPNPATRITFAEVIE 282 +L+ + R F +++ Sbjct: 269 LHQLMLDCWQKDRNHRPKFGQIVN 292 >4XBR-A nrPDB Length = 366 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 77/263 (29%), Positives = 136/263 (51%), Gaps = 16/263 (6%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 +GEG+ V A +G VA+K +D K + ++ + E+ M+ +H NV+ M+ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL---LFNEVVIMRDYQHENVVEMY 157 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V+EF+ GG L D I ++ R+ E++ ++ A+ H++GV HRD+ Sbjct: 158 NSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 216 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 K +++LL +G +K+SDFG A Q +E + GTP ++APE+I+ Y G + D+ Sbjct: 217 KSDSILLTHDGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDI 273 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP------WFSASAKKLIKRILDP 269 WS G+++ ++ G P+ + K I PP S S K + R+L Sbjct: 274 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---NLPPRLKNLHKVSPSLKGFLDRLLVR 330 Query: 270 NPATRITFAEVIENEWFKKGYKA 292 +PA R T AE++++ + K Sbjct: 331 DPAQRATAAELLKHPFLAKAGPP 353 >6QAU-A nrPDB Length = 280 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 85/284 (29%), Positives = 148/284 (52%), Gaps = 21/284 (7%) Query: 21 SSGGRTRVGKYELGR--TLGEGTFAKVKFARNV-ENGDNVAIKVIDKEKVLKNKMIAQIK 77 G VG +E + +G G FA V R+ + VAIK I+K+ + K++++ + Sbjct: 1 GGGSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LG 58 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 +EI +K ++H N++ +++V ++ V+E+ GG+L D + + G L ED R + Q Sbjct: 59 KEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQ 118 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLD---------ANGALKVSDFGLSALPQQVREDGLL 188 + A+ HS+G+ HRDLKP+N+LL + +K++DFG + + + Sbjct: 119 IAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHS---NMMA 175 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL---YKKIF 245 CG+P Y+APEVI ++ YD AKADLWS G +++ + G PF+ ++ L Y+K Sbjct: 176 ADLCGSPMYMAPEVIMSQHYD-AKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNR 234 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + P S L+ +L N R+ F + + ++G Sbjct: 235 SLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG 278 >4XCU-A nrPDB Length = 300 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 118/275 (42%), Gaps = 20/275 (7%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV-------ENGDNVAIKVIDKEKVLKNKMIAQIK 77 + LG+ LGEG F +V A + VA+K++ +K +A + Sbjct: 13 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK--DNASDKDLADLV 70 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-------GRLKED 129 E+ MKLI +H N+I + V + +Y ++E G L + + + G L Sbjct: 71 SEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFP 130 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 Q+ + Y SR HRDL N+L+ + +K++DFGL+ + Sbjct: 131 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 190 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE 248 ++APE + ++ Y ++D+WS G++L+ + G P+ + L+ + + Sbjct: 191 NGRLPVKWMAPEALFDRVY-THQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH 249 Query: 249 -FTCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 PP L++ P+ R TF +++E Sbjct: 250 RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >5H2U-A nrPDB Length = 267 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 70/259 (27%), Positives = 122/259 (47%), Gaps = 13/259 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++ L R LG G F +V + VAIKVI ++ +L +M ++ EI MK ++H Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISRDNLLHQQM---LQSEIQAMKKLRH 61 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVDYCH 146 +++ ++ V++ +Y + E + G L + + L E Q+ + Y Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN-YVAPEVINN 205 S+ HRDL N+L+ N KV DFGL+ L ++ED L P + APE + + Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARL---IKEDVYLSHDHNIPYKWTAPEAL-S 177 Query: 206 KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLI 263 +G+ K+D+WS G++L + + G +P+ + + ++ CP S KL+ Sbjct: 178 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM 237 Query: 264 KRILDPNPATRITFAEVIE 282 +P R TF + E Sbjct: 238 LTCWCRDPEQRPTFKALRE 256 >6HXF-B nrPDB Length = 302 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 75/265 (28%), Positives = 135/265 (50%), Gaps = 15/265 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +E+ LG+G F KV A+N E G A KVI + + + EI + HP Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI---ETKSEEELEDYIVEIEILATCDHPY 77 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDK-ISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++++ K++ ++EF GG + + + L E + + +Q++ A+++ HS+ Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV-----IN 204 + HRDLK N+L+ G ++++DFG+SA + ++ + GTP ++APEV + Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSA--KNLKTLQKRDSFIGTPYWMAPEVVMCETMK 195 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---CPPWFSASAKK 261 + YD KAD+WS G+ L + P + N + KI K++ P +S + Sbjct: 196 DTPYDY-KADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRD 254 Query: 262 LIKRILDPNPATRITFAEVIENEWF 286 +K LD NP TR + A+++E+ + Sbjct: 255 FLKIALDKNPETRPSAAQLLEHPFV 279 >5AWM-A nrPDB Length = 394 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 84/376 (22%), Positives = 140/376 (37%), Gaps = 71/376 (18%) Query: 14 RSTPSGSSSGGRTRVG--------KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE 65 R+ + VG +Y R +G G V A + NVAIK + + Sbjct: 21 RTMTTAQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR- 79 Query: 66 KVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDK 119 + RE MKL+ H N+I + + +Y V+E + L Sbjct: 80 PFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQV 138 Query: 120 ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALP 179 I + L D Q++ + + HS G+ HRDLKP N+++ A+ LK+ DFGL+ Sbjct: 139 IQMD--LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA 196 Query: 180 QQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 ++ T Y APEVI GY D+WS G I+ ++ G + F ++ Sbjct: 197 ---GTTFMMTPYVVTRYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHID 252 Query: 240 LYKKIFKAEFTCPPWFSA------------------------------------------ 257 + KI + T P F Sbjct: 253 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 312 Query: 258 -SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESK 316 A+ L+ ++L +P RI+ E +++E+ Y A + + +D S + + Sbjct: 313 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAP------APEPYDHSVDER 366 Query: 317 NLVVERREEGLKTPVT 332 VE+ +E + V Sbjct: 367 EHTVEQWKELIYEEVM 382 >4FR4-A nrPDB Length = 384 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 141/280 (50%), Gaps = 9/280 (3%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 S P +E+ R +G+G+F KV + + A+K ++K+K ++ + Sbjct: 1 SMPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVR 60 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 + +E+ M+ ++HP ++ ++ + ++ V++ + GG+L + N KE+ + + Sbjct: 61 NVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLF 120 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 +L+ A+DY ++ + HRD+KP+N+LLD +G + ++DF ++A+ + + + T GT Sbjct: 121 ICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPR---ETQITTMAGT 177 Query: 195 PNYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFE---DSNLTSLYKKIFKAEF 249 Y+APE+ +++ D WS GV + L+ G P+ ++ + Sbjct: 178 KPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVV 237 Query: 250 TCPPWFSASAKKLIKRILDPNPATRIT-FAEVIENEWFKK 288 T P +S L+K++L+PNP R + ++V + Sbjct: 238 TYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMND 277 >2HW6-A nrPDB Length = 307 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 83/303 (27%), Positives = 150/303 (49%), Gaps = 37/303 (12%) Query: 19 GSSSGGRTRVGK-YEL-GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 GS+ + Y+L LGEG +AKV+ A +++NG A+K+I+K+ +++ Sbjct: 1 GSTDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQA---GHSRSRV 57 Query: 77 KREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 RE+ T+ + + N++ + E T+ Y V E + GG + I E EA + Sbjct: 58 FREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVV 117 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDAN---GALKVSDFGLSALPQ-----QVREDGL 187 + + A+D+ H++G+ HRDLKPEN+L ++ +K+ DF L + + Sbjct: 118 RDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE 177 Query: 188 LHTTCGTPNYVAPEVIN----NKGYDGAKADLWSCGVILFVLMAGYLPFED--------- 234 L T CG+ Y+APEV+ + + DLWS GV+L+++++GY PF Sbjct: 178 LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWD 237 Query: 235 ------SNLTSLYKKIFKAEFTCPP----WFSASAKKLIKRILDPNPATRITFAEVIENE 284 L++ I + ++ P S+ AK LI ++L + R++ A+V+++ Sbjct: 238 RGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHP 297 Query: 285 WFK 287 W + Sbjct: 298 WVQ 300 >1V0B-A nrPDB Length = 288 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 81/293 (27%), Positives = 133/293 (45%), Gaps = 35/293 (11%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + KY +GEGT+ V A+N G+ A+K I EK + + REIS +K +K Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKE-DEGIPSTTIREISILKELK 58 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCH 146 H N++++++V+ +K ++ V E + +L + G L+ A+ + QL+N + YCH Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 R V HRDLKP+NLL++ G LK++DFGL+ T Y AP+V+ Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAF--GIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK-------------------- 246 D+WS G I ++ G F + +IF+ Sbjct: 176 KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYD 235 Query: 247 ---AEFTCPPW------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 + PW S L+ ++L +P RIT + +E+ +FK+ Sbjct: 236 PNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN 288 >5MJB-A nrPDB Length = 305 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 108/260 (41%), Gaps = 12/260 (4%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++ +G G F +V R G VAIK + K E S M H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG--YSEKQRRDFLSEASIMGQFDH 86 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHS 147 N+IR+ V+ + + EF+ L + N G+ + + + + Y Sbjct: 87 RNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSE 146 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVIN 204 HRDL N+L+++N KVSDFGLS Q D ++ G + APE I Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA 206 Query: 205 NKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAEFTCPP-WFSASAKKL 262 + + A +D+WS G++++ + G P+ D + + I + PP A+ +L Sbjct: 207 YRKFTSA-SDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQL 265 Query: 263 IKRILDPNPATRITFAEVIE 282 + + +R FAE++ Sbjct: 266 MLDCWQKDRNSRPRFAEIVN 285 >2X4F-A nrPDB Length = 373 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 78/259 (30%), Positives = 126/259 (48%), Gaps = 14/259 (5%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 LG G F +V G +A K+I + K ++K EIS M + H N+I++ Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM---KDKEEVKNEISVMNQLDHANLIQL 151 Query: 95 FEVMASKTKIYFVLEFVTGGELFDK-ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 ++ SK I V+E+V GGELFD+ I + L E + + +Q+ + + H + H Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHL 211 Query: 154 DLKPENLLLDANG--ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 DLKPEN+L +K+ DFGL+ + + L GTP ++APEV+N + Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLAR---RYKPREKLKVNFGTPEFLAPEVVNYD-FVSF 267 Query: 212 KADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLIKRIL 267 D+WS GVI ++L++G PF N I + S AK+ I ++L Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLL 327 Query: 268 DPNPATRITFAEVIENEWF 286 + RI+ +E +++ W Sbjct: 328 IKEKSWRISASEALKHPWL 346 >4EBW-A nrPDB Length = 304 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 118/267 (44%), Gaps = 11/267 (4%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQI 76 S+ + + ELGR +GEG F V + + VAIK + + + Sbjct: 29 STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK--NCTSDSVREKF 86 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYF 135 +E TM+ HP+++++ V+ ++ ++ ++E T GEL + L Y Sbjct: 87 LQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYA 145 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 QL A+ Y S+ HRD+ N+L+ +N +K+ DFGLS + Sbjct: 146 YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKL-PI 204 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAE-FTCPP 253 ++APE IN + + A +D+W GV ++ LM G PF+ + +I E PP Sbjct: 205 KWMAPESINFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 263 Query: 254 WFSASAKKLIKRILDPNPATRITFAEV 280 + L+ + +P+ R F E+ Sbjct: 264 NCPPTLYSLMTKCWAYDPSRRPRFTEL 290 >2WTK-C nrPDB Length = 305 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 93/288 (32%), Positives = 153/288 (53%), Gaps = 8/288 (2%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK-NKMIAQIKREISTMKLI 86 +GKY +G LGEG++ KVK + E A+K++ K+K+ + A +K+EI ++ + Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 87 KHPNVIRMFEVM--ASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAV 142 +H NVI++ +V+ K K+Y V+E+ G E+ D + R +A YF QLI+ + Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV-PEKRFPVCQAHGYFCQLIDGL 122 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 +Y HS+G+ H+D+KP NLLL G LK+S G++ D T+ G+P + PE+ Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 203 INN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 N + G K D+WS GV L+ + G PFE N+ L++ I K + P Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 242 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFE-NADVSLDDVDAI 308 L+K +L+ PA R + ++ ++ WF+K + + S D D Sbjct: 243 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRW 290 >1NY3-A nrPDB Length = 400 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 89/309 (28%), Positives = 150/309 (48%), Gaps = 33/309 (10%) Query: 28 VGKYEL-GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KL 85 + Y++ + LG G KV N + A+K++ + + +RE+ + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 111 Query: 86 IKHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLI 139 + P+++R+ +V + + + V+E + GGELF +I G E EA + + + Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 A+ Y HS + HRD+KPENLL + N LK++DFG + + L T C TP Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPY 228 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFT 250 YVAPEV+ + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF Sbjct: 229 YVAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Query: 251 CPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSLDDVD 306 P W S K LI+ +L P R+T E + + W + K P+ + V +D + Sbjct: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 347 Query: 307 AIFDDSGES 315 D E Sbjct: 348 RWEDVKEEM 356 >2OZA-A nrPDB Length = 356 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 89/309 (28%), Positives = 150/309 (48%), Gaps = 33/309 (10%) Query: 28 VGKYEL-GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KL 85 + Y++ + LG G KV N + A+K++ + + +RE+ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 86 IKHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLI 139 + P+++R+ +V + + + V+E + GGELF +I G E EA + + + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 A+ Y HS + HRD+KPENLL + N LK++DFG + + L T C TP Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPY 184 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFT 250 YVAPEV+ + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF Sbjct: 185 YVAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 243 Query: 251 CPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSLDDVD 306 P W S K LI+ +L P R+T E + + W + K P+ + V +D + Sbjct: 244 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 303 Query: 307 AIFDDSGES 315 D E Sbjct: 304 RWEDVKEEM 312 >3KA0-A nrPDB Length = 320 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 88/309 (28%), Positives = 149/309 (48%), Gaps = 33/309 (10%) Query: 28 VGKYEL-GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KL 85 + Y++ + LG G KV N + A+K++ + + +RE+ + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 65 Query: 86 IKHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLI 139 + P+++R+ +V + + + V+E + GGELF +I G E EA + + + Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 A+ Y HS + HRD+KPENLL + N LK++DFG + + L C TP Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTEPCYTPY 182 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFT 250 YVAPEV+ + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF Sbjct: 183 YVAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 241 Query: 251 CPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSLDDVD 306 P W S K LI+ +L P R+T E + + W + K P+ + V +D + Sbjct: 242 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 301 Query: 307 AIFDDSGES 315 D E Sbjct: 302 RWEDVKEEM 310 >6CCF-A nrPDB Length = 290 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 81/291 (27%), Positives = 146/291 (50%), Gaps = 32/291 (10%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKV-----------IDKEKVLKNKM--- 72 ++ +Y+L +G+G + V+ A N + A+KV + + Sbjct: 3 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 73 ---------IAQIKREISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVTGGELFDKIS 121 + ++ +EI+ +K + H NV+++ EV+ + +Y V + + G + + + Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VP 121 Query: 122 SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQ 181 + E++AR Y + +I ++Y H + + HRD+KP NLLL +G +K++DFG+S + Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 180 Query: 182 VREDGLLHTTCGTPNYVAPEVI--NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 D L +T GTP ++APE I + + + G D+W+ GV L+ + G PF D + + Sbjct: 181 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 240 LYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 L++KI P P S K LI ++LD NP TRI ++ + W K Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >4E93-A nrPDB Length = 377 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 64/255 (25%), Positives = 110/255 (43%), Gaps = 6/255 (2%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 LG +G G F +V R + VA+K + L + A+ +E +K H Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQEARILKQYSH 171 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHS 147 PN++R+ V K IY V+E V GG+ + + G RL+ + ++Y S Sbjct: 172 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 231 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 + HRDL N L+ LK+SDFG+S + APE +N G Sbjct: 232 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY-G 290 Query: 208 YDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFK-AEFTCPPWFSASAKKLIKR 265 +++D+WS G++L+ G P+ + + + + K CP + +L+++ Sbjct: 291 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 350 Query: 266 ILDPNPATRITFAEV 280 P R +F+ + Sbjct: 351 CWAYEPGQRPSFSTI 365 >3PPZ-A nrPDB Length = 309 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 69/274 (25%), Positives = 123/274 (44%), Gaps = 15/274 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 + +G G+F V A +G +VA+K++ E+ + + + RE++ MK ++HP Sbjct: 38 DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILM-EQDFHAERVNEFLREVAIMKRLRHP 94 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG---RLKEDEARKYFQQLINAVDYCH 146 N++ + + V E+++ G L+ + +G +L E + ++Y H Sbjct: 95 NIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLH 154 Query: 147 SRG--VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 +R + HRDLK NLL+D +KV DFGLS L + GTP ++APEV+ Sbjct: 155 NRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS--KSAAGTPEWMAPEVLR 212 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI--FKAEFTCPPWFSASAKKL 262 ++ K+D++S GVIL+ L P+ + N + + P + + Sbjct: 213 DEP-SNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAI 271 Query: 263 IKRILDPNPATRITFAEV--IENEWFKKGYKAPK 294 I+ P R +FA + + K P Sbjct: 272 IEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPN 305 >4U41-A nrPDB Length = 332 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 85/336 (25%), Positives = 140/336 (41%), Gaps = 31/336 (9%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 + +P++S S R G +EL +G GT+ +V R+V+ G AIKV+D Sbjct: 3 ANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD---- 58 Query: 68 LKNKMIAQIKREISTMKLI-KHPNVIRMFEVMA------SKTKIYFVLEFVTGGELFDKI 120 + +IK EI+ +K H N+ + +++ V+EF G + D + Sbjct: 59 VTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLV 118 Query: 121 S--SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL 178 LKED ++++ + + H V HRD+K +N+LL N +K+ DFG+SA Sbjct: 119 KNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQ 178 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGY----DGAKADLWSCGVILFVLMAGYLPFED 234 + G +T GTP ++APEVI ++DLWSCG+ + G P D Sbjct: 179 LDRTV--GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCD 236 Query: 235 SNLTSLYKKIFKAEFTCPPWF-----SASAKKLIKRILDPNPATRITFAEVIENEWFKKG 289 + I PP S I+ L N R + +++++ + + Sbjct: 237 MHPMRALFLI---PRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRD- 292 Query: 290 YKAPKFENADVSLDD-VDAIFDDSGESKNLVVERRE 324 P + L D +D GE E Sbjct: 293 --QPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSG 326 >3TT0-A nrPDB Length = 382 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 123/285 (43%), Gaps = 29/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFA------RNVENG-DNVAIKVIDKEKVLKNKMIAQIK 77 + LG+ LGEG F +V A ++ N VA+K++ + K ++ + Sbjct: 65 ELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD--ATEKDLSDLI 122 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------- 125 E+ MK+I KH N+I + +Y ++E+ + G L + + + Sbjct: 123 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSH 182 Query: 126 -----LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 L + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ Sbjct: 183 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 242 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE + ++ Y ++D+WS GV+L+ + G P+ + Sbjct: 243 HIDYYKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 301 Query: 240 LYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 L+K + + P + +++ P+ R TF +++E+ Sbjct: 302 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >3E7O-A nrPDB Length = 360 Score = 251 bits (641), Expect = 5e-67, Method: Composition-based stats. Identities = 78/355 (21%), Positives = 138/355 (38%), Gaps = 62/355 (17%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T + +Y+ + +G G V A + G NVA+K + + + RE+ +K Sbjct: 19 TVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKC 77 Query: 86 IKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + H N+I + V + +Y V+E + L I L + Q++ Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME--LDHERMSYLLYQML 134 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ + ++ T Y A Sbjct: 135 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---STNFMMTPYVVTRYYRA 191 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------------ 247 PEVI GY D+WS G I+ L+ G + F+ ++ + K+ + Sbjct: 192 PEVILGMGY-KENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAAL 250 Query: 248 -------------------EFTCPPWFSAS-----------AKKLIKRILDPNPATRITF 277 E P W S A+ L+ ++L +P RI+ Sbjct: 251 QPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISV 310 Query: 278 AEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPVT 332 E + + + Y + E I+D E + +E +E + V Sbjct: 311 DEALRHPYITVWYDPAEAEAPPP------QIYDAQLEEREHAIEEWKELIYKEVM 359 >6BXI-A nrPDB Length = 333 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 90/333 (27%), Positives = 147/333 (44%), Gaps = 49/333 (14%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + +E + +G G F +V+ + + G A+K++ K +L+ + + I+ E + Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 V++MF K +Y ++EF+ GG++ + L E+E + Y + + A+D Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH--------------- 189 H G HRD+KP+NLLLD+ G +K+SDFGL ++ Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 190 ------------------TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 +T GTP+Y+APEV GY+ D WS GVI++ ++ GY P Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKL-CDWWSLGVIMYEMLIGYPP 240 Query: 232 FEDSNLTSLYKKIF--KAEFTCPPW--FSASAKKLIKR-ILDPNPATRITF---AEVIEN 283 F YKK+ K T PP S AK LI R + RI E+ N Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEW--EHRIGAPGVEEIKSN 298 Query: 284 EWFKKG-----YKAPKFENADVSLDDVDAIFDD 311 +F+ + P + ++ D + FD+ Sbjct: 299 SFFEGVDWEHIRERPAAISIEIKSIDDTSNFDE 331 >3DKO-A nrPDB Length = 318 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 109/261 (41%), Gaps = 10/261 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMK 84 ++ R +G G F +V R G VAIK + K E S M Sbjct: 42 ASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG--YTEKQRRDFLCEASIMG 99 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVD 143 HPNV+ + V+ + V+EF+ G L + + G+ + + + + Sbjct: 100 QFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMR 159 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEV 202 Y G HRDL N+L+++N KVSDFGLS + + E T P + APE Sbjct: 160 YLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEA 219 Query: 203 INNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAK 260 I + + A +D+WS G++++ + G P+ D + + K I + P A Sbjct: 220 IQYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLH 278 Query: 261 KLIKRILDPNPATRITFAEVI 281 +L+ A R F +++ Sbjct: 279 QLMLDCWQKERAERPKFEQIV 299 >2Y6O-A nrPDB Length = 291 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 109/262 (41%), Gaps = 10/262 (3%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMK 84 ++ + +G G F +V R G VAIK + +K E S M Sbjct: 13 ASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAG--YTDKQRRDFLSEASIMG 70 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVD 143 HPN+I + V+ + + E++ G L + N GR + + + + + Sbjct: 71 QFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMK 130 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEV 202 Y HRDL N+L+++N KVSDFG+S + + E P + APE Sbjct: 131 YLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA 190 Query: 203 INNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAEFTCPP-WFSASAK 260 I + + A +D+WS G++++ + G P+ D + + K I + PP + Sbjct: 191 IAYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALH 249 Query: 261 KLIKRILDPNPATRITFAEVIE 282 +L+ + R F +++ Sbjct: 250 QLMLDCWQKERSDRPKFGQIVN 271 >1KOB-A nrPDB Length = 387 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 133/285 (46%), Gaps = 14/285 (4%) Query: 13 SRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM 72 + P + Y++ LG G F V G K I+ L Sbjct: 35 KKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK-- 92 Query: 73 IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEA 131 +K EIS M + HP +I + + K ++ +LEF++GGELFD+I + + ++ E E Sbjct: 93 -YTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEV 151 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH 189 Y +Q + + H + H D+KPEN++ + A +K+ DFGL+ ++ D ++ Sbjct: 152 INYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLAT---KLNPDEIVK 208 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEF 249 T T + APE+++ + G D+W+ GV+ +VL++G PF + + + + ++ Sbjct: 209 VTTATAEFAAPEIVDREPV-GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDW 267 Query: 250 TCPP----WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 S AK IK +L P R+T + +E+ W K + Sbjct: 268 EFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >6E2O-A nrPDB Length = 295 Score = 251 bits (640), Expect = 7e-67, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 134/295 (45%), Gaps = 19/295 (6%) Query: 13 SRSTPSGSSSGGRTRVGKYELGR-----TLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 SRST G YE LG+GT+ V R++ N +AIK I + Sbjct: 2 SRSTEEGDCESDLLEY-DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPER-- 58 Query: 68 LKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRL 126 ++ + EI+ K +KH N+++ + I +E V GG L + S G L Sbjct: 59 -DSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL 117 Query: 127 K--EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVR 183 K E Y +Q++ + Y H + HRD+K +N+L++ +G LK+SDFG S + Sbjct: 118 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN 177 Query: 184 EDGLLHTTCGTPNYVAPEVINNKGY-DGAKADLWSCGVILFVLMAGYLPFE--DSNLTSL 240 T GT Y+APE+I+ G AD+WS G + + G PF ++ Sbjct: 178 P--CTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAM 235 Query: 241 YKK-IFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 294 +K +FK P SA AK I + +P+P R +++ +E+ K K K Sbjct: 236 FKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKK 290 >4QNY-A nrPDB Length = 354 Score = 251 bits (640), Expect = 7e-67, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 146/340 (42%), Gaps = 49/340 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARN-VENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 +Y L R +G G++ V AR+ + VA+K ++KE + + +I REI + Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 88 HPNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 N+I + ++ + Y V++ + +L + S L E + + Q + A+ Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQFFIYQALRAL 138 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 HS GV HRD+ P N+L++ N LK+ DFGL+ ++ + + Y APE+ Sbjct: 139 HIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK--EENDQGEYMTDYVTMRWYRAPEL 196 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI------------------ 244 + A+ D+W G IL L+ F+ + + KI Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 245 -----FKAEFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 K + P P S A L++ +L NP RIT + + + + ++ + Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLH- 315 Query: 292 APKFENADVSLDDVDAIFDDSGESKNLVVERR---EEGLK 328 ++AD +L FD++ E K +V +R EE +K Sbjct: 316 ----DDADDNLSYALFRFDEN-EQKTIVDVKRAIYEESVK 350 >3GC9-A nrPDB Length = 370 Score = 250 bits (639), Expect = 9e-67, Method: Composition-based stats. Identities = 77/333 (23%), Positives = 138/333 (41%), Gaps = 53/333 (15%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 + + R +G G + V A + VA+K + + + RE+ +K +KH Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHE 87 Query: 90 NVIRMFEVMASKT------KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 NVI + +V T ++Y V + G +L + I + L ++ + QL+ + Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLK 145 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 Y HS G+ HRDLKP N+ ++ + L++ DFGL+ + D + T Y APE++ Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLAR-----QADEEMTGYVATRWYRAPEIM 200 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF-------- 255 N + D+WS G I+ L+ G F S+ K+I + T P Sbjct: 201 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 260 Query: 256 -----------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + A L+ R+L + R++ AE + + +F + + Sbjct: 261 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 Query: 293 PKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 A+ +D+S E+K +E +E Sbjct: 321 EDEPEAE--------PYDESVEAKERTLEEWKE 345 >3HKO-A nrPDB Length = 345 Score = 250 bits (639), Expect = 9e-67, Method: Composition-based stats. Identities = 86/311 (27%), Positives = 138/311 (44%), Gaps = 51/311 (16%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK--NKMIAQIKREISTMKLI 86 KY L +G+G++ V+ A + AIK+++K K+ + K + +IK E+ MK + Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS------------------------ 122 HPN+ R++EV + I V+E GG L DK++ Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 123 ------------NGRLK----EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG 166 L E +Q+ +A+ Y H++G+ HRD+KPEN L N Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 167 --ALKVSDFGLSALPQQVREDGLL--HTTCGTPNYVAPEVIN-NKGYDGAKADLWSCGVI 221 +K+ DFGLS ++ T GTP +VAPEV+N G K D WS GV+ Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 222 LFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPPW--FSASAKKLIKRILDPNPATRITF 277 L +L+ G +PF N ++ + F P + S A+ L+ +L+ N R Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDA 325 Query: 278 AEVIENEWFKK 288 +++ W + Sbjct: 326 MRALQHPWISQ 336 >2F9G-A nrPDB Length = 353 Score = 250 bits (639), Expect = 9e-67, Method: Composition-based stats. Identities = 89/345 (25%), Positives = 136/345 (39%), Gaps = 58/345 (16%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++L LGEG + V A + G+ VAIK I E K + REI +K KH Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 Query: 89 PNVIRMF-----EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 N+I +F + + ++Y + E + +L I S L +D + + Q + AV Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVI-STQMLSDDHIQYFIYQTLRAVK 126 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL--------LHTTCGTP 195 H V HRDLKP NLL+++N LKV DFGL+ + + D + T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF---------- 245 Y APEV+ D+WSCG IL L F + IF Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 246 --------------KAEFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIEN 283 K+ P P + L++R+L +PA RIT E +E+ Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 284 EWFKKGYKA---PKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 + + + P+ E S F+ + L + ++ Sbjct: 307 PYLQTYHDPNDEPEGEPIPPSF------FEFDHYKEALTTKDLKK 345 >5A46-A nrPDB Length = 386 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 123/285 (43%), Gaps = 29/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFA------RNVENG-DNVAIKVIDKEKVLKNKMIAQIK 77 + LG+ LGEG F +V A ++ N VA+K++ + K ++ + Sbjct: 36 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD--ATEKDLSDLI 93 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------- 125 E+ MK+I KH N+I + +Y ++E+ + G L + + + Sbjct: 94 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 153 Query: 126 -----LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 L + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ Sbjct: 154 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 213 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE + ++ Y ++D+WS GV+L+ + G P+ + Sbjct: 214 HIDYYKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 272 Query: 240 LYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 L+K + + P + +++ P+ R TF +++E+ Sbjct: 273 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >3GQL-A nrPDB Length = 326 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 123/285 (43%), Gaps = 29/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFA------RNVENG-DNVAIKVIDKEKVLKNKMIAQIK 77 + LG+ LGEG F +V A ++ N VA+K++ + K ++ + Sbjct: 24 ELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD--ATEKDLSDLI 81 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------- 125 E+ MK+I KH N+I + +Y ++E+ + G L + + + Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 141 Query: 126 -----LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 L + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ Sbjct: 142 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 201 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE + ++ Y ++D+WS GV+L+ + G P+ + Sbjct: 202 HIDYYKKTTNGRLPVKWMAPEALFDRIY-THQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 260 Query: 240 LYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 L+K + + P + +++ P+ R TF +++E+ Sbjct: 261 LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >1JNK-A nrPDB Length = 423 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 77/355 (21%), Positives = 136/355 (38%), Gaps = 62/355 (17%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T + +Y+ + +G G V A + NVAIK + + + RE+ MK Sbjct: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 117 Query: 86 IKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + H N+I + V + +Y V+E + L I L + Q++ Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQML 174 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y A Sbjct: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRA 231 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK------------- 246 PEVI GY D+WS G I+ ++ + F + + K+ + Sbjct: 232 PEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 Query: 247 --------------AEFTCPPWFSAS---------------AKKLIKRILDPNPATRITF 277 A T P F S A+ L+ ++L +PA RI+ Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Query: 278 AEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPVT 332 + +++ + Y + E I+D + + +E +E + V Sbjct: 351 DDALQHPYINVWYDPAEVEAPPP------QIYDKQLDEREHTIEEWKELIYKEVM 399 >5TUR-A nrPDB Length = 404 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 86/297 (28%), Positives = 143/297 (48%), Gaps = 20/297 (6%) Query: 2 ASRTTPSRSTPSRSTPSGSSSGGRTRV---GKYELGRTLGEGTFAKVKFARNVENGDNVA 58 + R+ P + + G+ + +Y++G LG G F V V + VA Sbjct: 97 INSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVA 156 Query: 59 IKVIDKEKVLKNKMIA---QIKREISTMKLIKHPN--VIRMFEVMASKTKIYFVLEFVTG 113 IK ++K+++ + ++ E+ +K + VIR+ + +LE Sbjct: 157 IKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP 216 Query: 114 -GELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN-GALKVS 171 +LFD I+ G L+E+ AR +F Q++ AV +CH+ GV HRD+K EN+L+D N G LK+ Sbjct: 217 VQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLI 276 Query: 172 DFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 DFG AL + D + GT Y PE I Y G A +WS G++L+ ++ G +P Sbjct: 277 DFGSGALLK----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 332 Query: 232 FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 FE ++I + + S+ + LI+ L P+ R TF E+ + W + Sbjct: 333 FEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 383 >2J0K-A nrPDB Length = 656 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 119/275 (43%), Gaps = 13/275 (4%) Query: 12 PSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVL 68 + + PS + + ELGR +GEG F V + + VAIK Sbjct: 375 DTYTMPSTR--DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK--NCT 430 Query: 69 KNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LK 127 + + + +E TM+ HP+++++ V+ ++ ++ ++E T GEL + L Sbjct: 431 SDSVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLD 489 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL 187 Y QL A+ Y S+ HRD+ N+L+ A +K+ DFGLS + Sbjct: 490 LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKA 549 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFK 246 ++APE IN + + A +D+W GV ++ LM G PF+ + +I Sbjct: 550 SKGKL-PIKWMAPESINFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN 607 Query: 247 AE-FTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 E PP + L+ + +P+ R F E+ Sbjct: 608 GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL 642 >4QTB-A nrPDB Length = 380 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 129/334 (38%), Gaps = 42/334 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y + +GEG + V A + VAIK I + + REI + +H Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE 99 Query: 90 NVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 NVI + +++ + T +Y V + + +L+ + S L D + Q++ + Y Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQILRGLKY 157 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV-REDGLLHTTCGTPNYVAPEVI 203 HS V HRDLKP NLL++ LK+ DFGL+ + G L T Y APE++ Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF-------KAEFTC----- 251 N D+WS G IL +++ F + I + + C Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 252 -------------------PPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 P + A L+ R+L NP RIT E + + + ++ Y Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 337 Query: 293 PKFENADVSLDDVDAIFDDSGES-KNLVVERREE 325 A+ + D E K L+ + Sbjct: 338 TDEPVAEEPFTFAMELDDLPKERLKELIFQETAR 371 >3V5Q-A nrPDB Length = 297 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 109/280 (38%), Gaps = 27/280 (9%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARN-----VENGDNVAIKVIDKEKVLKNKMIAQIKR 78 + L R LGEG F KV A ++ VA+K + + K +R Sbjct: 10 QHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARK---DFQR 66 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR------------- 125 E + ++H ++++ + V + V E++ G+L + ++G Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 126 ---LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 L + Q+ + + Y S+ HRDL N L+ AN +K+ DFG+S Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 183 REDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLY 241 + T ++ PE I + + ++D+WS GVIL+ + G P+ + T + Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTT-ESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 242 KKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 + I + P ++ P R+ E+ Sbjct: 246 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >3BGP-A nrPDB Length = 333 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 86/297 (28%), Positives = 143/297 (48%), Gaps = 20/297 (6%) Query: 2 ASRTTPSRSTPSRSTPSGSSSGGRTRV---GKYELGRTLGEGTFAKVKFARNVENGDNVA 58 + R+ P + + G+ + +Y++G LG G F V V + VA Sbjct: 26 INSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVA 85 Query: 59 IKVIDKEKVLKNKMIA---QIKREISTMKLIKHPN--VIRMFEVMASKTKIYFVLEFVTG 113 IK ++K+++ + ++ E+ +K + VIR+ + +LE Sbjct: 86 IKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP 145 Query: 114 -GELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN-GALKVS 171 +LFD I+ G L+E+ AR +F Q++ AV +CH+ GV HRD+K EN+L+D N G LK+ Sbjct: 146 VQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLI 205 Query: 172 DFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 DFG AL + D + GT Y PE I Y G A +WS G++L+ ++ G +P Sbjct: 206 DFGSGALLK----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 261 Query: 232 FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 FE ++I + + S+ + LI+ L P+ R TF E+ + W + Sbjct: 262 FEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 312 >3FXW-A nrPDB Length = 336 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 85/313 (27%), Positives = 145/313 (46%), Gaps = 44/313 (14%) Query: 29 GKYELGR-TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 Y+L + LG G KV + G A+K++ + ++E+ Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY--------DSPKARQEVD-----H 74 Query: 88 H------PNVIRMFEVMASKTK----IYFVLEFVTGGELFDKISSNG--RLKEDEARKYF 135 H P+++ + +V + + ++E + GGELF +I G E EA + Sbjct: 75 HWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIM 134 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTC 192 + + A+ + HS + HRD+KPENLL + + LK++DFG + Q L T C Sbjct: 135 RDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ----NALQTPC 190 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFK 246 TP YVAPEV+ + YD + D+WS GVI+++L+ G+ PF + ++ ++ + Sbjct: 191 YTPYYVAPEVLGPEKYDKS-CDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 249 Query: 247 AEFTCPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSL 302 F P W S AK+LI+ +L +P R+T + + + W + P+ A V Sbjct: 250 YGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQ 309 Query: 303 DDVDAIFDDSGES 315 +D D + E Sbjct: 310 EDKDHWDEVKEEM 322 >2VD5-A nrPDB Length = 412 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 84/326 (25%), Positives = 150/326 (46%), Gaps = 31/326 (9%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + +E+ + +G G F++V + + G A+K+++K +LK ++ + E + Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVD 143 + ++ + +Y V+E+ GG+L +S G R+ + AR Y +++ A+D Sbjct: 117 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT--CGTPNYVAPE 201 H G HRD+KP+N+LLD G ++++DFG ++R DG + + GTP+Y++PE Sbjct: 177 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL---KLRADGTVRSLVAVGTPDYLSPE 233 Query: 202 VIN------NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI--FKAEFTCP- 252 ++ G G + D W+ GV + + G PF + Y KI +K + P Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 293 Query: 253 --PWFSASAKKLIKRILDPNPATRI---TFAEVIENEWFKKGYKAPKFENADVSLDDVDA 307 A+ I+R+L P P TR+ + + +F F L D Sbjct: 294 VDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFF--------FGLDWDGLRDSVP 344 Query: 308 IF--DDSGESKNLVVERREEGLKTPV 331 F D G + + E+GL V Sbjct: 345 PFTPDFEGATDTCNFDLVEDGLTAMV 370 >5NGU-A nrPDB Length = 381 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 127/334 (38%), Gaps = 42/334 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +Y +GEG + V A + N VAIK I + + REI + +H Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFE--HQTYCQRTLREIKILLRFRHE 100 Query: 90 NVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 N+I + +++ + T +Y V + + +L+ + + L D + Q++ + Y Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKY 158 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV-REDGLLHTTCGTPNYVAPEVI 203 HS V HRDLKP NLLL+ LK+ DFGL+ + G L T Y APE++ Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF------------------ 245 N D+WS G IL +++ F + I Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 246 --KAEFTCP-----------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + P P + A L+ ++L NP RI + + + + ++ Y Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 293 PKFENADVSLDDVDAIFDDSGES-KNLVVERREE 325 A+ + D E K L+ E Sbjct: 339 SDEPIAEAPFKFDMELDDLPKEKLKELIFEETAR 372 >3ZDU-A nrPDB Length = 325 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 123/296 (41%), Gaps = 35/296 (11%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 YE +GEG++ V ++ G VAIK+ + IA REI +K H N Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIA--MREIKFLKQFHHEN 62 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 ++ + EV K KI+ V EF+ L + L+ RKY Q++ A+DY HS + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 151 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 HRD+KPEN+L+ +G K+ DFG + + T Y APE++ G Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAA--PGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSAS-------- 258 D+W+ G ++ + G S+ L KI P FS S Sbjct: 181 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 240 Query: 259 -------------------AKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 ++ L +PA RI+ ++++ +E+F + KF Sbjct: 241 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKF 296 >4NST-A nrPDB Length = 351 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 139/323 (43%), Gaps = 48/323 (14%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S G+ V K+++ +GEGT+ +V A++ + G+ VA+K + + + I I REI Sbjct: 5 SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REI 63 Query: 81 STMKLIKHPNVIRMFEVMASKTK----------IYFVLEFVTGGELFDKISSN-GRLKED 129 ++ + H +V+ M E++ K Y V E++ +L + S ED Sbjct: 64 KILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSED 122 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 + + +QL+ ++YCH + HRD+K N+LL+ +G +K++DFGL+ L E Sbjct: 123 HIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS-EESRPYT 181 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK-AE 248 T Y PE++ + D+WSCG IL L F+ + + + I + Sbjct: 182 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCG 241 Query: 249 FTCPP-----------------------------WFSASAKKLIKRILDPNPATRITFAE 279 CP + ++A L+ +L +P+ R T + Sbjct: 242 SPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQ 301 Query: 280 VIENEWFKK----GYKAPKFENA 298 +++++ K P + Sbjct: 302 TLQSDFLKDVELSKMAPPDLPHW 324 >2VWV-A nrPDB Length = 302 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 111/259 (42%), Gaps = 12/259 (4%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++ +G G F +V R G VAIK + + + E S M +H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK--GGYTERQRREFLSEASIMGQFEH 76 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHS 147 PN+IR+ V+ + + + EF+ G L + N G+ + + + + + Y Sbjct: 77 PNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAE 136 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVIN 204 HRDL N+L+++N KVSDFGLS ++ D ++ G + APE I Sbjct: 137 MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA 196 Query: 205 NKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFK-AEFTCPPWFSASAKKL 262 + + A +D WS G++++ + G P+ D + + I + PP S +L Sbjct: 197 FRKFTSA-SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQL 255 Query: 263 IKRILDPNPATRITFAEVI 281 + + R F +V+ Sbjct: 256 MLDCWQKDRNARPRFPQVV 274 >2R2P-A nrPDB Length = 295 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 107/265 (40%), Gaps = 10/265 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREIS 81 + R +G G F +V R G VAIK + K E S Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG--YTEKQRRDFLGEAS 75 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLIN 140 M HPN+I + V+ + V E++ G L + N G+ + + + Sbjct: 76 IMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISA 135 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVA 199 + Y G HRDL N+L+++N KVSDFGLS + + E P + A Sbjct: 136 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 195 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLYKKIFKA-EFTCPPWFSA 257 PE I + + A +D+WS G++++ ++ G P+ + + K + + P A Sbjct: 196 PEAIAFRKFTSA-SDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 254 Query: 258 SAKKLIKRILDPNPATRITFAEVIE 282 + +L+ +R F E++ Sbjct: 255 ALYQLMLDCWQKERNSRPKFDEIVN 279 >2H8H-A nrPDB Length = 535 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 119/297 (40%), Gaps = 29/297 (9%) Query: 16 TPSGSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL 68 P+ +E+ R LG+G F +V VAIK + + Sbjct: 247 CPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS 305 Query: 69 KNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRL 126 +E MK ++H +++++ V+ S+ IY V E+++ G L D + L Sbjct: 306 P----EAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYL 360 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 + + Q+ + + Y HRDL+ N+L+ N KV+DFGL+ L ED Sbjct: 361 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----EDN 416 Query: 187 LLHTTCG---TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYK 242 G + APE G K+D+WS G++L L G +P+ + Sbjct: 417 EYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 475 Query: 243 KIFKA-EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY--KAPKFE 296 ++ + CPP S L+ + P R TF + + + + P+++ Sbjct: 476 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL--QAFLEDYFTSTEPQYQ 530 >5L6P-A nrPDB Length = 298 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 109/264 (41%), Gaps = 12/264 (4%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMK 84 V ++ +G G F +V R + G VAIK + + E S M Sbjct: 18 VSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG--YTERQRRDFLSEASIMG 75 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVD 143 HPN+IR+ V+ + + EF+ L + N G+ + + + + Sbjct: 76 QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMK 135 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAP 200 Y HRDL N+L+++N KVSDFGLS + D ++ G + AP Sbjct: 136 YLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAP 195 Query: 201 EVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAEFTCPP-WFSAS 258 E I + + A +D+WS G++++ + G P+ D + + + + PP + Sbjct: 196 EAIAYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTA 254 Query: 259 AKKLIKRILDPNPATRITFAEVIE 282 +L+ + R F++++ Sbjct: 255 LHQLMLDCWVRDRNLRPKFSQIVN 278 >4UY9-A nrPDB Length = 323 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 145/326 (44%), Gaps = 32/326 (9%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK-NKMIAQIKREISTMKLI 86 + L +G G F KV A + GD VA+K + ++ I +++E ++ Sbjct: 8 FAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 65 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 KHPN+I + V + + V+EF GG L +++ S R+ D + Q+ ++Y H Sbjct: 66 KHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 147 SRG---VYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 + HRDLK N+L+ +N LK++DFGL+ + + + GT Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK----MSAAGTY 180 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPP 253 ++APEVI + +D+WS GV+L+ L+ G +PF + ++ + + P Sbjct: 181 AWMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 239 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVI-------ENEWFKKGYKAPKFENADVSLD-DV 305 KL++ +P+P +R +F ++ E+ +F+ F + ++ Sbjct: 240 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEM--PKDSFHCLQDNWKHEI 297 Query: 306 DAIFDDSGESKNLVVERREEGLKTPV 331 +FD + + EE + + Sbjct: 298 QEMFDQLRAKEKELRTWEEELTRAAL 323 >4P5Q-A nrPDB Length = 361 Score = 248 bits (633), Expect = 5e-66, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 114/278 (41%), Gaps = 15/278 (5%) Query: 16 TPSGSSSGGRTRVGKYE-----LGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKV 67 P GS+ + + + + +G G F +V R VAIK + Sbjct: 15 VPRGSTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG-- 72 Query: 68 LKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRL 126 K E S M HPN+IR+ V+ + V E++ G L + + + Sbjct: 73 YTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQF 132 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 + + + + + Y G HRDL N+L+++N KVSDFGLS + + E Sbjct: 133 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 192 Query: 187 LLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKI 244 P + +PE I + + A +D+WS G++L+ + G P+ + + + K + Sbjct: 193 YTTRGGKIPIRWTSPEAIAYRKFTSA-SDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAV 251 Query: 245 FKAEFTCPP-WFSASAKKLIKRILDPNPATRITFAEVI 281 + PP A+ +L+ + R F +++ Sbjct: 252 DEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIV 289 >5EFQ-A nrPDB Length = 347 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 76/311 (24%), Positives = 134/311 (43%), Gaps = 44/311 (14%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G G+ V K+++ +GEGT+ +V AR+ + G+ VA+K + + + I I R Sbjct: 1 GDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-R 59 Query: 79 EISTMKLIKHPNVIRMFEVMASKTK----------IYFVLEFVTGGELFDKISSN-GRLK 127 EI ++ + H ++I M E++ K Y V E++ +L + S Sbjct: 60 EIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFN 118 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL 187 E+ + + +QL+ +DYCH + HRD+K N+LL+ G +K++DFGL+ L E Sbjct: 119 ENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS-EESRP 177 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK- 246 T Y PE++ + D+WSCG IL L F+ + + + I + Sbjct: 178 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRI 237 Query: 247 AEFTCPP-----------------------------WFSASAKKLIKRILDPNPATRITF 277 CP + A+A L +L +P+ R T Sbjct: 238 CGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTA 297 Query: 278 AEVIENEWFKK 288 + ++ E+ + Sbjct: 298 EQALQCEFLRD 308 >6GQK-A nrPDB Length = 328 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 109/284 (38%), Gaps = 28/284 (9%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 + G+TLG G F KV A + VA+K++ + + E Sbjct: 37 EFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTER--EALMSE 94 Query: 80 ISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-------------- 124 + + + H N++ + + E+ G+L + + Sbjct: 95 LKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLY 154 Query: 125 --RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 L + + Q+ + + S+ HRDL N+LL K+ DFGL+ + Sbjct: 155 KDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKND 214 Query: 183 REDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLY 241 ++APE I N Y ++D+WS G+ L+ L + G P+ + S + Sbjct: 215 SNYVDKGNARLPVKWMAPESIFNSVY-TFESDVWSYGIFLWELFSLGSSPYPGMPVDSKF 273 Query: 242 KKIFKAEFTC--PPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 K+ K F P + A ++K D +P R TF +++++ Sbjct: 274 YKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >4AT3-A nrPDB Length = 299 Score = 247 bits (632), Expect = 7e-66, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 24/262 (9%) Query: 33 LGRTLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 L R LGEG F KV A ++ VA+K + K + RE + ++ Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL---KDASDNARKDFHREAELLTNLQ 73 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-------------LKEDEARKY 134 H ++++ + V + V E++ G+L + ++G L + + Sbjct: 74 HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHI 133 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 QQ+ + Y S+ HRDL N L+ N +K+ DFG+S + T Sbjct: 134 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 193 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCP 252 ++ PE I + + ++D+WS GV+L+ + G P+ + + + I + P Sbjct: 194 IRWMPPESIMYRKFTT-ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 252 Query: 253 PWFSASAKKLIKRILDPNPATR 274 +L+ P R Sbjct: 253 RTCPQEVYELMLGCWQREPHMR 274 >6F3F-A nrPDB Length = 455 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 118/297 (39%), Gaps = 29/297 (9%) Query: 16 TPSGSSSGGRTRVGKYELGR-------TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVL 68 P+ +E+ R LG+G F +V VAIK + + Sbjct: 167 CPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS 225 Query: 69 KNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRL 126 +E MK ++H +++++ V+ S+ IY V E++ G L D + L Sbjct: 226 P----EAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYL 280 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 + + Q+ + + Y HRDL+ N+L+ N KV+DFGL+ L ED Sbjct: 281 RLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----EDN 336 Query: 187 LLHTTCG---TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYK 242 G + APE G K+D+WS G++L L G +P+ + Sbjct: 337 EYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 395 Query: 243 KIFKA-EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY--KAPKFE 296 ++ + CPP S L+ + P R TF + + + + P+++ Sbjct: 396 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL--QAFLEDYFTSTEPQYQ 450 >3NYO-A nrPDB Length = 576 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 128/269 (47%), Gaps = 15/269 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + R LG+G F +V + G A K ++K+++ K K A E ++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHSR 148 V+ + +K + VL + GG+L I G+ E A Y ++ ++ H Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 + +RDLKPEN+LLD +G +++SD GL+ V E + GT Y+APEV+ N+ Y Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERY 362 Query: 209 DGAKADLWSCGVILFVLMAGYLPFED----SNLTSLYKKIFKAEFTCPPWFSASAKKLIK 264 + D W+ G +L+ ++AG PF+ + + + + FS A+ L Sbjct: 363 TFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Query: 265 RILDPNPATRI-----TFAEVIENEWFKK 288 ++L +PA R+ + EV E+ FKK Sbjct: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKK 450 >1UA2-A nrPDB Length = 346 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 83/321 (25%), Positives = 127/321 (39%), Gaps = 40/321 (12%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID--KEKVLKNKMIAQIKREIST 82 ++R +YE LGEG FA V AR+ VAIK I K+ + REI Sbjct: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINA 141 ++ + HPN+I + + K+ I V +F+ +L I N L + Y + Sbjct: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 ++Y H + HRDLKP NLLLD NG LK++DFGL+ + T Y APE Sbjct: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPE 182 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK-----AEFTCPPWFS 256 ++ G D+W+ G IL L+ + +IF+ E P S Sbjct: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 Query: 257 -----------------------ASAKKLIKRILDPNPATRITFAEVIENEWF------K 287 LI+ + NP RIT + ++ ++F Sbjct: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 Query: 288 KGYKAPKFENADVSLDDVDAI 308 G + P+ +L + Sbjct: 303 PGCQLPRPNCPVETLKEQSNP 323 >6CQF-A nrPDB Length = 297 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 71/266 (26%), Positives = 127/266 (47%), Gaps = 12/266 (4%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R Y+L + LG GT+ +V AR+ +GD VA+K++ E + ++ +++EI +K Sbjct: 12 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDVSTLQKEILILK 68 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 +H N++ K++ +EF G L D G L E + ++++ + Y Sbjct: 69 TCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAY 128 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV-- 202 HS+ HRD+K N+L++ G ++++DFG+SA L GTP ++APEV Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRL--AFIGTPYWMAPEVAA 186 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP-----WFSA 257 + KG D+WS G+ L P D + + + K+ + P +SA Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSA 246 Query: 258 SAKKLIKRILDPNPATRITFAEVIEN 283 + IK L +P R + +++ + Sbjct: 247 AFHNFIKVTLTKSPKKRPSATKMLSH 272 >4X7Q-B nrPDB Length = 312 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 88/267 (32%), Positives = 136/267 (50%), Gaps = 19/267 (7%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR---EISTMKLI 86 +Y LG LG+G F V + + VAIKVI + +VL ++ E++ + + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 87 K----HPNVIRMFEVMASKTKIYFVLE-FVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 HP VIR+ + ++ VLE + +LFD I+ G L E +R +F Q++ A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 142 VDYCHSRGVYHRDLKPENLLLD-ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 + +CHSRGV HRD+K EN+L+D G K+ DFG AL D GT Y P Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH----DEPYTDFDGTRVYSPP 207 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 E I+ Y A +WS G++L+ ++ G +PFE ++I +AE P S Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCC 261 Query: 261 KLIKRILDPNPATRITFAEVIENEWFK 287 LI+R L P P++R + E++ + W + Sbjct: 262 ALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >2XS0-A nrPDB Length = 386 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 74/355 (20%), Positives = 134/355 (37%), Gaps = 62/355 (17%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T + +Y+ + +G G V A + NVAIK + + + RE+ MK Sbjct: 23 TVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 81 Query: 86 IKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + H N+I + V + +Y V+E + L I L + Q++ Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME--LDHERMSYLLYQML 138 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y A Sbjct: 139 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMVPFVVTRYYRA 195 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSAS- 258 PEVI GY D+WS G I+ ++ G + F ++ + K+ + T P F Sbjct: 196 PEVILGMGY-KENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 254 Query: 259 -----------------------------------------AKKLIKRILDPNPATRITF 277 A+ L+ ++L + + RI+ Sbjct: 255 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 314 Query: 278 AEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKTPVT 332 E +++ + Y + E + D + + +E +E + V Sbjct: 315 DEALQHPYINVWYDPSEAEAPPPKIPDKQ------LDEREHTIEEWKELIYKEVM 363 >5SYS-A nrPDB Length = 286 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 113/270 (41%), Gaps = 22/270 (8%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LG+G F + VAIK + + +E MK ++H +++++ Sbjct: 25 KLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQLY 79 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ S+ IY V E+++ G L D + L+ + Q+ + + Y HR Sbjct: 80 AVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVINNKGYDG 210 DL+ N+L+ N KV+DFGL+ L ED G + APE G Sbjct: 139 DLRAANILVGENLVCKVADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALY-GRFT 193 Query: 211 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILD 268 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 194 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 253 Query: 269 PNPATRITFAEVIENEWFKKGY--KAPKFE 296 +P R TF + + + + P+++ Sbjct: 254 KDPEERPTFEYL--QAFLEDYFTSTEPQYQ 281 >4RC3-A nrPDB Length = 289 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 83/267 (31%), Positives = 134/267 (50%), Gaps = 17/267 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA---QIKREISTMKL 85 +Y++G LG G F V V + VAIK ++K+++ + ++ E+ +K Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 86 IKHPN--VIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINAV 142 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ AV Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 131 Query: 143 DYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 +CH+ GV HRD+K EN+L+D N G LK+ DFG AL + D + GT Y PE Sbjct: 132 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTRVYSPPE 187 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 I Y G A +WS G++L+ ++ G +PFE ++I + + S+ + Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQH 241 Query: 262 LIKRILDPNPATRITFAEVIENEWFKK 288 LI+ L P+ R TF E+ + W + Sbjct: 242 LIRWCLALRPSDRPTFEEIQNHPWMQD 268 >1K9A-A nrPDB Length = 450 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 71/270 (26%), Positives = 126/270 (46%), Gaps = 21/270 (7%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 SG + + +L +T+G+G F V G+ VA+K I + + E S Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA-----FLAEAS 238 Query: 82 TMKLIKHPNVIRMFEVM-ASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQL 138 M ++H N++++ V+ K +Y V E++ G L D + S GR L D K+ + Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 A++Y HRDL N+L+ + KVSDFGL+ ++ G L + Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWT 353 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFS 256 APE + K + K+D+WS G++L+ + + G +P+ L + ++ K + P Sbjct: 354 APEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 Query: 257 ASAKKLIKRILDPNPATRITFAEV---IEN 283 + ++K + ATR TF ++ +E+ Sbjct: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >3DTC-A nrPDB Length = 271 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 126/268 (47%), Gaps = 22/268 (8%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK-NKMIAQIKREISTMKLI 86 + L +G G F KV A + GD VA+K + ++ I +++E ++ Sbjct: 6 FAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 63 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 KHPN+I + V + + V+EF GG L +++ S R+ D + Q+ ++Y H Sbjct: 64 KHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLH 122 Query: 147 SRG---VYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 + HRDLK N+L+ +N LK++DFGL+ + + + G Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK----MSAAGAY 178 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPP 253 ++APEVI + +D+WS GV+L+ L+ G +PF + ++ + + P Sbjct: 179 AWMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 237 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVI 281 KL++ +P+P +R +F ++ Sbjct: 238 TCPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >5VO2-A nrPDB Length = 300 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 118/267 (44%), Gaps = 18/267 (6%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 GS + + +G G V R G+ VA+K + K Sbjct: 2 GSEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD--------- 50 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 I ++ +KHPN+I V ++EF G+L++ + + + + + Sbjct: 51 -IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 109 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++Y H + HRDLK N+L+ + +K+SDFG S ++ + + GT ++ Sbjct: 110 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFAGTVAWM 166 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPWFS 256 APEVI N+ K D+WS GV+L+ L+ G +P++D + +++ + P Sbjct: 167 APEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 225 Query: 257 ASAKKLIKRILDPNPATRITFAEVIEN 283 K L+++ + P R +F +++ + Sbjct: 226 DGFKILLRQCWNSKPRNRPSFRQILLH 252 >4UYA-A nrPDB Length = 340 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 139/331 (41%), Gaps = 28/331 (8%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKRE 79 S + EL +G G F +V A G VA+K ++ A+ ++RE Sbjct: 18 GSPVHVAFERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRRE 75 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 +++HPN+I + V + + VLEF GG L ++ R+ + Q+ Sbjct: 76 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGR-RIPPHVLVNWAVQIA 134 Query: 140 NAVDYCHSRG---VYHRDLKPENLLLDA--------NGALKVSDFGLSALPQQVREDGLL 188 + Y H + HRDLK N+LL N LK++DFGL+ + + Sbjct: 135 RGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK---- 190 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF--K 246 T G ++APEVI + + +D+WS GV+L+ L+ G +P+ + ++ + K Sbjct: 191 MATAGAYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK 249 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN-EWFKKGYKAPKFENADVSLDD- 304 P KL+K +P R +FA ++E + + + S+ D Sbjct: 250 LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD 309 Query: 305 ----VDAIFDDSGESKNLVVERREEGLKTPV 331 + +FD+ + + R EE + + Sbjct: 310 WKLEIQQMFDELRTKEKELRSREEELTRAAL 340 >4TNB-A nrPDB Length = 590 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 72/268 (26%), Positives = 128/268 (47%), Gaps = 15/268 (5%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + R LG+G F +V + G A K ++K+++ K K + E ++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVDYCHSR 148 V+ + +K + VL + GG+L I + N +E+ A Y +++ ++ H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 +RDLKPEN+LLD G +++SD GL+ ++ E L+ GT Y+APEV+NN+ Y Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNL----TSLYKKIFKAEFTCPPWFSASAKKLIK 264 G D W G +++ ++ G PF + +++ + E FS AK + K Sbjct: 363 -GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Query: 265 RILDPNPATRIT-----FAEVIENEWFK 287 +L + R+ AEV + +F+ Sbjct: 422 MLLTKDAKQRLGCQEEEAAEVKRHPFFR 449 >3KUL-B nrPDB Length = 325 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 109/264 (41%), Gaps = 10/264 (3%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREIS 81 + + + +G G +V + R G VAIK + + E S Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG--YTERQRRDFLSEAS 102 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLIN 140 M HPN+IR+ V+ V E++ G L + ++ G+ + + + Sbjct: 103 IMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 162 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVA 199 + Y G HRDL N+L+D+N KVSDFGLS + + + T P + A Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 200 PEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKA-EFTCPPWFSA 257 PE I + + + +D+WS GV+++ L G P+ + + + + P Sbjct: 223 PEAIAFRTF-SSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 281 Query: 258 SAKKLIKRILDPNPATRITFAEVI 281 + +L+ + A R F++++ Sbjct: 282 ALHQLMLDCWHKDRAQRPRFSQIV 305 >2PSQ-A nrPDB Length = 370 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 122/285 (42%), Gaps = 29/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFA----RNVENGDN---VAIKVIDKEKVLKNKMIAQIK 77 K LG+ LGEG F +V A + + VA+K++ + K ++ + Sbjct: 77 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD--ATEKDLSDLV 134 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------- 125 E+ MK+I KH N+I + +Y ++E+ + G L + + + Sbjct: 135 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 194 Query: 126 -----LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 + + QL ++Y S+ HRDL N+L+ N +K++DFGL+ Sbjct: 195 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 254 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE + ++ Y ++D+WS GV+++ + G P+ + Sbjct: 255 NIDYYKKTTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 313 Query: 240 LYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 L+K + + P + +++ P+ R TF +++E+ Sbjct: 314 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >3OZ6-A nrPDB Length = 388 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 77/377 (20%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 R + KYEL + LG+G + V + + G+ VA+K I + + + REI + Sbjct: 5 RHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMILT 63 Query: 85 LIK-HPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 + H N++ + V+ + +Y V +++ +L I +N L+ + QLI Sbjct: 64 ELSGHENIVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRAN-ILEPVHKQYVVYQLIKV 121 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVR------------------ 183 + Y HS G+ HRD+KP N+LL+A +KV+DFGLS +R Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 184 -EDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK 242 + +L T Y APE++ D+WS G IL ++ G F S+ + + Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 243 KIFKA-----------------------------------------------EFTCPPWF 255 +I + Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADC 301 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSL-----DDVDAIFD 310 + A L+ ++L NP RI+ + +++ + + + N D + D+V D Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSID 361 Query: 311 DSGESKNLVVERREEGL 327 D + RR+ L Sbjct: 362 DYRNLVYSEISRRKREL 378 >1U5R-A nrPDB Length = 348 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 129/297 (43%), Gaps = 18/297 (6%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 R +G G+F V FAR+V N + VAIK + N+ I +E+ ++ ++HPN I+ Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVYH 152 + + V+E+ G D + + + L+E E + + Y HS + H Sbjct: 119 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIH 177 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI--NNKGYDG 210 RD+K N+LL G +K+ DFG +++ ++ GTP ++APEVI ++G Sbjct: 178 RDVKAGNILLSEPGLVKLGDFGSASIMAP------ANSFVGTPYWMAPEVILAMDEGQYD 231 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--WFSASAKKLIKRILD 268 K D+WS G+ L P + N S I + E +S + + L Sbjct: 232 GKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQ 291 Query: 269 PNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 P R T ++++ + + V +D + D E NL + ++ Sbjct: 292 KIPQDRPTSEVLLKHRFVLRERPP------TVIMDLIQRTKDAVRELDNLQYRKMKK 342 >4H1J-A nrPDB Length = 293 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 117/272 (43%), Gaps = 12/272 (4%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFAR---NVENGDNVAIKVIDKEKVLKNKM 72 P GS G R L R LGEG F +V + NVA+K K+ L NK Sbjct: 12 VPRGSPQYGIAR-EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK- 69 Query: 73 IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEA 131 + E MK + HP+++++ ++ + + ++E GEL + N LK Sbjct: 70 -EKFMSEAVIMKNLDHPHIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTL 127 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 Y Q+ A+ Y S HRD+ N+L+ + +K+ DFGLS + T Sbjct: 128 VLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTR 187 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-F 249 +++PE IN + + A +D+W V ++ +++ G PF + + K + Sbjct: 188 L-PIKWMSPESINFRRFTTA-SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRL 245 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 P L+ R D +P+ R F E++ Sbjct: 246 PKPDLCPPVLYTLMTRCWDYDPSDRPRFTELV 277 >2XNP-A nrPDB Length = 279 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 79/274 (28%), Positives = 136/274 (49%), Gaps = 16/274 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 +R YE+ T+G G++ + + R +G + K +D + + + + E++ ++ Sbjct: 2 PSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEK-QMLVSEVNLLR 60 Query: 85 LIKHPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKI----SSNGRLKEDEARKYFQQL 138 +KHPN++R ++ + +T +Y V+E+ GG+L I L E+ + QL Sbjct: 61 ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL 120 Query: 139 INAVDYCHSRG-----VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 A+ CH R V HRDLKP N+ LD +K+ DFGL+ + + T G Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNH--DTSFAKTFVG 178 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEF-TCP 252 TP Y++PE +N Y+ K+D+WS G +L+ L A PF + L KI + +F P Sbjct: 179 TPYYMSPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIP 237 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 +S ++I R+L+ R + E++EN Sbjct: 238 YRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >1BYG-A nrPDB Length = 278 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 126/270 (46%), Gaps = 21/270 (7%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 SG + + +L +T+G+G F V G+ VA+K I + + E S Sbjct: 14 SGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA-----FLAEAS 66 Query: 82 TMKLIKHPNVIRMFEVM-ASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQL 138 M ++H N++++ V+ K +Y V E++ G L D + S GR L D K+ + Sbjct: 67 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 126 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 A++Y HRDL N+L+ + KVSDFGL+ ++ G L + Sbjct: 127 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWT 181 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFS 256 APE + K + K+D+WS G++L+ + + G +P+ L + ++ K + P Sbjct: 182 APEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 240 Query: 257 ASAKKLIKRILDPNPATRITFAEV---IEN 283 + +++K + A R +F ++ +E+ Sbjct: 241 PAVYEVMKNCWHLDAAMRPSFLQLREQLEH 270 >2DQ7-X nrPDB Length = 283 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 67/274 (24%), Positives = 114/274 (41%), Gaps = 22/274 (8%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 +L + LG G F +V VAIK + + E MK +KH + Sbjct: 12 QLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSP----ESFLEEAQIMKKLKHDKL 66 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKIS--SNGRLKEDEARKYFQQLINAVDYCHSRG 149 ++++ V+ S+ IY V E++ G L D + LK Q+ + Y Sbjct: 67 VQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 125 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVINNK 206 HRDL+ N+L+ K++DFGL+ L ED G + APE Sbjct: 126 YIHRDLRSANILVGNGLICKIADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALY- 180 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIK 264 G K+D+WS G++L L+ G +P+ N + +++ + CP S +L+ Sbjct: 181 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240 Query: 265 RILDPNPATRITFAEVIENEWFKKGYKA--PKFE 296 +P R TF + + + + A P+++ Sbjct: 241 HCWKKDPEERPTFEYL--QSFLEDYFTATEPQYQ 272 >2GCD-A nrPDB Length = 309 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 129/297 (43%), Gaps = 18/297 (6%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 R +G G+F V FAR+V N + VAIK + N+ I +E+ ++ ++HPN I+ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRGVYH 152 + + V+E+ G D + + + L+E E + + Y HS + H Sbjct: 80 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIH 138 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI--NNKGYDG 210 RD+K N+LL G +K+ DFG +++ ++ GTP ++APEVI ++G Sbjct: 139 RDVKAGNILLSEPGLVKLGDFGSASIMAP------ANSFVGTPYWMAPEVILAMDEGQYD 192 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--WFSASAKKLIKRILD 268 K D+WS G+ L P + N S I + E +S + + L Sbjct: 193 GKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQ 252 Query: 269 PNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 P R T ++++ + + V +D + D E NL + ++ Sbjct: 253 KIPQDRPTSEVLLKHRFVLRERPP------TVIMDLIQRTKDAVRELDNLQYRKMKK 303 >4OLI-A nrPDB Length = 645 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 125/305 (40%), Gaps = 29/305 (9%) Query: 2 ASRTTPSRSTPSRSTPSGSSSGGRTRV-GKY-ELGRTLGEGTFAKVKFA----RNVENGD 55 +R P + S + T +Y + R LGEG F KV N G+ Sbjct: 324 LTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGE 383 Query: 56 NVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTK--IYFVLEFVTG 113 VA+K + + + + K+EI ++ + H ++I+ + + + V+E+V Sbjct: 384 MVAVKALKAD--CGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPL 441 Query: 114 GELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDF 173 G L D + + + + + QQ+ + Y HS+ HR+L N+LLD + +K+ DF Sbjct: 442 GSLRDYLPRH-SIGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDF 500 Query: 174 GLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMAG---- 228 GL+ + E + +P + APE + + A +D+WS GV L+ L+ Sbjct: 501 GLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYA-SDVWSFGVTLYELLTHCDSS 559 Query: 229 -YLP--F--------EDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRIT 276 P F + L + + + E P L+K + + R T Sbjct: 560 QSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPT 619 Query: 277 FAEVI 281 F +I Sbjct: 620 FENLI 624 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 87/248 (35%), Gaps = 24/248 (9%) Query: 48 ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFV 107 R+ V +KV+D + S M + H ++ + V + V Sbjct: 88 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 144 Query: 108 LEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL---- 162 E+V G L + G + QQL +A+ Y ++ + H ++ N+LL Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 204 Query: 163 ---DANGALKVSDF--GLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD-GAKADLW 216 + +K+SD GL AL ++ R + ++APE + D W Sbjct: 205 LAEGTSPFIKLSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKW 256 Query: 217 SCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 G L + G P + + + + P A L + L P R Sbjct: 257 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRP 315 Query: 276 TFAEVIEN 283 +F ++ + Sbjct: 316 SFRTILRD 323 >4K33-A nrPDB Length = 325 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 121/280 (43%), Gaps = 29/280 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGD-------NVAIKVIDKEKVLKNKMIAQIKREIST 82 + LG+ LGEG F +V A + VA+K++ + +K ++ + E+ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDD--ATDKDLSDLVSEMEM 94 Query: 83 MKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR---------------- 125 MK+I KH N+I + +Y ++E+ G L + + + Sbjct: 95 MKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQ 154 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 L + Q+ ++Y S+ HRDL N+L+ + +K++DFGL+ + Sbjct: 155 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 214 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKI 244 ++APE + ++ Y ++D+WS GV+L+ + G P+ + L+K + Sbjct: 215 KETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL 273 Query: 245 FKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + P + +++ P+ R TF +++E+ Sbjct: 274 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >4OTD-A nrPDB Length = 341 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 79/313 (25%), Positives = 137/313 (43%), Gaps = 21/313 (6%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 + ++ LG G F KV + +G+ AIK + K ++ + + E + Sbjct: 7 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 66 Query: 84 KLI---KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 + HP ++ +F + + FV+E+ GG+L I S+ E A Y ++ Sbjct: 67 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVL 125 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 + + H + +RDLK +NLLLD G +K++DFGL + + T CGTP ++AP Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK--EGMGYGDRTSTFCGTPEFLAP 183 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 260 EV+ + Y D W GV+L+ ++ G PF + ++ I E P + SA A Sbjct: 184 EVLTDTSY-TRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAI 242 Query: 261 KLIKRILDPNPATRIT-----FAEVIENEWFK--------KGYKAPKFENADVSLDDVDA 307 +++R+L NP R+ +V + +F+ P F DV Sbjct: 243 GIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSN 302 Query: 308 IFDDSGESKNLVV 320 FD+ + + Sbjct: 303 -FDEEFTGEAPTL 314 >4LQP-A nrPDB Length = 508 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 79/389 (20%), Positives = 140/389 (35%), Gaps = 85/389 (21%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 + + +G+G F +V+ + + G A+K + K ++ K +A +K E + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 P V+ ++ +Y ++EF+ GG+L + ED R Y + I A++ H Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH------------------- 189 G HR +KP+N+L+D G +K+SDFGLS + + Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 190 -----------------------------TTCGTPNYVA-----------PEVINNKGYD 209 T + +A PE+ +GY Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGY- 340 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE--FTCPP--WFSASAKKLIKR 265 G + D WS G I++ + G+ PF Y+KI E P S A+ LI+R Sbjct: 341 GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRR 400 Query: 266 ILDPNPATRI----TFAEVIENEWFK-------KGYKAPKFENADVSLDDVDAIFDDSGE 314 +L + R+ E+ + +F+ + +AP D D+ Sbjct: 401 LLT-HADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELEN 459 Query: 315 SK---------NLVVERREEGLKTPVTMN 334 + ++G PV + Sbjct: 460 VPDSPAMAQAAKQREQMTKQGGSAPVKED 488 >4XLV-A nrPDB Length = 328 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 129/315 (40%), Gaps = 25/315 (7%) Query: 1 MASRTTPSRSTPSRSTPSGS--SSGGRTRVGKYELGRTLGEGTFAKVKF--ARNVENGD- 55 + + + P + S PS K L R LG+G+F V AR++ G+ Sbjct: 9 LFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEA 68 Query: 56 --NVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTG 113 VA+K +++ L+ ++ + E S MK +V+R+ V++ V+E + Sbjct: 69 ETRVAVKTVNESASLRERI--EFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH 126 Query: 114 GELFDKISSNGRLKE----------DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD 163 G+L + S E E + ++ + + Y +++ HRDL N ++ Sbjct: 127 GDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA 186 Query: 164 ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILF 223 + +K+ DFG++ + ++APE + + + + +D+WS GV+L+ Sbjct: 187 HDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTS-SDMWSFGVVLW 245 Query: 224 VLMA-GYLPFEDSNLTSLYKKIFKAEF-TCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + + P++ + + K + + P L++ NP R TF E++ Sbjct: 246 EITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIV 305 Query: 282 ENEWFKKGYKAPKFE 296 K P F Sbjct: 306 N---LLKDDLHPSFP 317 >3SXS-A nrPDB Length = 268 Score = 242 bits (617), Expect = 4e-64, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 127/263 (48%), Gaps = 16/263 (6%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + + L + LG G F VK + D VA+K+I + + +++ +E TM Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDE----FFQEAQTMM 58 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVD 143 + HP +++ + V + + IY V E+++ G L + + S+G+ L+ + + + + Sbjct: 59 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMA 118 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAP 200 + S HRDL N L+D + +KVSDFG++ D ++ GT + AP Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVL----DDQYVSSVGTKFPVKWSAP 174 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWF-SAS 258 EV + Y +K+D+W+ G++++ + + G +P++ + + K+ + P S + Sbjct: 175 EVFHYFKY-SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDT 233 Query: 259 AKKLIKRILDPNPATRITFAEVI 281 +++ P R TF +++ Sbjct: 234 IYQIMYSCWHELPEKRPTFQQLL 256 >1G3N-A nrPDB Length = 326 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 86/312 (27%), Positives = 137/312 (43%), Gaps = 46/312 (14%) Query: 30 KYELGRTLGEGTFAKVKFARNVENG-DNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 87 +YE +GEG + KV AR+++NG VA+K + + + M RE++ ++ ++ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR-VQTGEEGMPLSTIREVAVLRHLET 70 Query: 88 --HPNVIRMFEVMA-----SKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQL 138 HPNV+R+F+V +TK+ V E V +L + + + + QL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 + +D+ HS V HRDLKP+N+L+ ++G +K++DFGL+ + L + T Y Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTSVVVTLWYR 186 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK-----AEFTCPP 253 APEV+ Y DLWS G I + F S+ KI E P Sbjct: 187 APEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 254 WF--------SASA--------------KKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 S SA K L+ + L NPA RI+ + + +F+ + Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 Query: 292 APKFENADVSLD 303 EN D L Sbjct: 306 CK--ENLDSHLP 315 >6CKI-A nrPDB Length = 316 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 85/303 (28%), Positives = 145/303 (47%), Gaps = 37/303 (12%) Query: 19 GSSSGGRTRVGK-YELGR-TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 GS+ R Y+L LGEG A+V+ N+ A+K+I+K+ + +++ Sbjct: 1 GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQ---PGHIRSRV 57 Query: 77 KREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 RE+ + + H NV+ + E + + Y V E + GG + I E EA Sbjct: 58 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVV 117 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGA---LKVSDFGLSALPQ-----QVREDGL 187 Q + +A+D+ H++G+ HRDLKPEN+L + +K+ DFGL + + Sbjct: 118 QDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPE 177 Query: 188 LHTTCGTPNYVAPEVI----NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS---- 239 L T CG+ Y+APEV+ + DLWS GVIL++L++GY PF + Sbjct: 178 LLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 237 Query: 240 -----------LYKKIFKAEFTCPP----WFSASAKKLIKRILDPNPATRITFAEVIENE 284 L++ I + ++ P S +AK LI ++L + R++ A+V+++ Sbjct: 238 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 297 Query: 285 WFK 287 W + Sbjct: 298 WVQ 300 >5KMM-A nrPDB Length = 329 Score = 240 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 106/280 (37%), Gaps = 28/280 (10%) Query: 36 TLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 LGEG F KV A ++ VA+K + K +RE + +++H + Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL---KEASESARQDFQREAELLTMLQHQH 98 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR---------------LKEDEARKYF 135 ++R F V + V E++ G+L + S+G L + Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q+ + Y HRDL N L+ +K+ DFG+S + T Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI 218 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPP 253 ++ PE I + + ++D+WS GV+L+ + G P+ + T I + E P Sbjct: 219 RWMPPESILYRKFTT-ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 277 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 +++ P R + +V + + +AP Sbjct: 278 ACPPEVYAIMRGCWQREPQQRHSIKDV--HARLQALAQAP 315 >3VN9-A nrPDB Length = 340 Score = 240 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 130/296 (43%), Gaps = 16/296 (5%) Query: 3 SRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI 62 + +TP R S++ S + + E LG G + V+ R+V +G +A+K I Sbjct: 25 TSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 Query: 63 DKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK--- 119 + + + +IS M+ + P + + + + ++ +E + L Sbjct: 85 RATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQ 142 Query: 120 -ISSNGRLKEDEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANGALKVSDFGLSA 177 I + ED K ++ A+++ HS+ V HRD+KP N+L++A G +K+ DFG+S Sbjct: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVIN---NKGYDGAKADLWSCGVILFVLMAGYLPF-- 232 + + G Y+APE IN N+ K+D+WS G+ + L P+ Sbjct: 203 ---YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 Query: 233 EDSNLTSLYKKIFKAEFTCP-PWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + L + + + P FSA + L N R T+ E++++ +F Sbjct: 260 WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >1FVR-A nrPDB Length = 327 Score = 240 bits (613), Expect = 9e-64, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 112/274 (40%), Gaps = 27/274 (9%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + +GEG F +V AR ++G + AIK + + E+ + + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK--EYASKDDHRDFAGELEVLCKL 82 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED---------------- 129 HPN+I + + +Y +E+ G L D + + L+ D Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 + + + +DY + HRDL N+L+ N K++DFGLS + + + Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGR 202 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA- 247 ++A E +N Y +D+WS GV+L+ +++ G P+ LY+K+ + Sbjct: 203 LPV---RWMAIESLNYSVYTT-NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGY 258 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 P L+++ P R +FA+++ Sbjct: 259 RLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >4XI2-A nrPDB Length = 446 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 127/292 (43%), Gaps = 19/292 (6%) Query: 1 MASRTTPSRSTPSRSTPSGSS---SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNV 57 + SR S +++ PS + + LG G F VK+ + D V Sbjct: 156 LISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-V 214 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 AIK+I + + +++ I E M + H +++++ V + I+ + E++ G L Sbjct: 215 AIKMIREGSMSEDEFIE----EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 270 Query: 118 DKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS 176 + + R + + + + + A++Y S+ HRDL N L++ G +KVSDFGLS Sbjct: 271 NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS 330 Query: 177 ALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPF 232 D ++ G+ + PEV+ + +K+D+W+ GV+++ + + G +P+ Sbjct: 331 RYVL----DDEYTSSVGSKFPVRWSPPEVLMYSKF-SSKSDIWAFGVLMWEIYSLGKMPY 385 Query: 233 EDSNLTSLYKKIFKAEFTCPPWF-SASAKKLIKRILDPNPATRITFAEVIEN 283 E + + I + P S ++ R +F ++ N Sbjct: 386 ERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSN 437 >4CRS-A nrPDB Length = 341 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 141/319 (44%), Gaps = 21/319 (6%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S S + + + L G F KV A + AIK + K ++ + + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 78 REISTMK---LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 E + ++HP ++ +F +K + FV+E+ GG+L I ++ E A Y Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFY 119 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 ++ + Y H + +RDLK +NLLLD G +K++DFGL + + T CGT Sbjct: 120 AACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK--EGMGYGDRTSTFCGT 177 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW 254 P ++APEV+ Y D W GV+++ ++ G PF + ++ I E P + Sbjct: 178 PEFLAPEVLTETSY-TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRF 236 Query: 255 FSASAKKLIKRILDPNPATRITFAE-----VIENEWFK--------KGYKAPKFENADVS 301 S A +++R+L NP R+ +E V ++ +F+ P F Sbjct: 237 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRG 296 Query: 302 LDDVDAIFDDSGESKNLVV 320 +DV FDD S+ ++ Sbjct: 297 REDVSN-FDDEFTSEAPIL 314 >2OGV-A nrPDB Length = 317 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 55/268 (20%), Positives = 108/268 (40%), Gaps = 22/268 (8%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN-----VAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + G+TLG G F KV A G VA+K++ K + E+ M + Sbjct: 41 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIMSHL 98 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN----------GRLKEDEARKYF 135 +H N++ + + + E+ G+L + + L+ + + Sbjct: 99 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFS 158 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 Q+ + + S+ HRD+ N+LL K+ DFGL+ + Sbjct: 159 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPV 218 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTC--P 252 ++APE I + Y ++D+WS G++L+ + + G P+ + S + K+ K + P Sbjct: 219 KWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQP 277 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEV 280 + + +++ P R TF ++ Sbjct: 278 AFAPKNIYSIMQACWALEPTHRPTFQQI 305 >5EG3-A nrPDB Length = 334 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 121/285 (42%), Gaps = 29/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFA----RNVENGDN---VAIKVIDKEKVLKNKMIAQIK 77 K LG+ LGEG F +V A + + VA+K++ + K ++ + Sbjct: 31 EFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD--ATEKDLSDLV 88 Query: 78 REISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------- 125 E+ MK+I KH N+I + +Y ++ + + G L + + + Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINR 148 Query: 126 -----LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 + + QL ++Y S+ HRDL N+L+ N +K++DFGL+ Sbjct: 149 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 208 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE + ++ Y ++D+WS GV+++ + G P+ + Sbjct: 209 NIDFFKETTNGRLPVKWMAPEALFDRVY-THQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 267 Query: 240 LYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 L+K + + P + +++ P+ R TF +++E+ Sbjct: 268 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4GS6-A nrPDB Length = 315 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 137/320 (42%), Gaps = 34/320 (10%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 + E+ +G G F V A+ +VAIK I+ E K E+ + + H Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKA-----FIVELRQLSRVNH 61 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK---EDEARKYFQQLINAVDYC 145 PN+++++ + V+E+ GG L++ + L A + Q V Y Sbjct: 62 PNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 146 HS---RGVYHRDLKPENLLLDANGAL-KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 HS + + HRDLKP NLLL A G + K+ DFG + Q + G+ ++APE Sbjct: 120 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-----THMTNNKGSAAWMAPE 174 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP---WFSAS 258 V Y K D++S G+IL+ ++ PF++ + T PP Sbjct: 175 VFEGSNY-SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKP 233 Query: 259 AKKLIKRILDPNPATRITFAEVIE---N--EWFKKGYKAPKF--ENADVSLDD--VDAIF 309 + L+ R +P+ R + E+++ + +F + ++ +++ +D V+ Sbjct: 234 IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRVEPYV 293 Query: 310 DDSGESKNLVVERREEGLKT 329 D + + V+ E+ + T Sbjct: 294 DFAEFYRLWSVDHGEQSVVT 313 >5UUU-A nrPDB Length = 547 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 72/272 (26%), Positives = 133/272 (48%), Gaps = 15/272 (5%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI- 86 + + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 87 --KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 316 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 H+R V +RDLKP N+LLD +G +++SD GL+ + + H + GT Y+APEV+ Sbjct: 317 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQ 372 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 + AD +S G +LF L+ G+ PF + + + + P FS + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 262 LIKRILDPNPATRI-----TFAEVIENEWFKK 288 L++ +L + R+ EV E+ +F+ Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 464 >3DLS-A nrPDB Length = 335 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 80/272 (29%), Positives = 134/272 (49%), Gaps = 15/272 (5%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-----IKREISTMK 84 KY LG G F V A + E V +K I KEKVL++ I + EI+ + Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGG-ELFDKISSNGRLKEDEARKYFQQLINAVD 143 ++H N+I++ ++ ++ V+E G +LF I + RL E A F+QL++AV Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 Y + + HRD+K EN+++ + +K+ DFG +A ++ + L +T CGT Y APEV+ Sbjct: 145 YLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK---LFYTFCGTIEYCAPEVL 201 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 263 Y G + ++WS GV L+ L+ PF + ++ +A P S L+ Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLV 255 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +L P P R T +++ + W + + Sbjct: 256 SGLLQPVPERRTTLEKLVTDPWVTQPVNLADY 287 >4AN9-A nrPDB Length = 301 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 118/274 (43%), Gaps = 10/274 (3%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 + G + +E LG G V + +G +A K+I E +K + QI RE+ Sbjct: 2 ALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQ 59 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 + P ++ + S +I +E + GG L + GR+ E K +I Sbjct: 60 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 119 Query: 142 VDYC-HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 + Y + HRD+KP N+L+++ G +K+ DFG+S D + + GT +Y++P Sbjct: 120 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DEMANEFVGTRSYMSP 175 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW--FSAS 258 E + + ++D+WS G+ L + G P + L I P FS Sbjct: 176 ERLQG-THYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLE 234 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + + + L NPA R +++ + + K+ Sbjct: 235 FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 268 >3BEA-A nrPDB Length = 333 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 108/272 (39%), Gaps = 26/272 (9%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN-----VAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + G+TLG G F KV A G VA+K++ K + E+ M + Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIMSHL 106 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--------------LKEDEA 131 +H N++ + + + E+ G+L + + R L + Sbjct: 107 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDL 166 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 + Q+ + + S+ HRD+ N+LL K+ DFGL+ + Sbjct: 167 LHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNA 226 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFT 250 ++APE I + Y ++D+WS G++L+ + + G P+ + S + K+ K + Sbjct: 227 RLPVKWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 285 Query: 251 C--PPWFSASAKKLIKRILDPNPATRITFAEV 280 P + + +++ P R TF ++ Sbjct: 286 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >3QGY-A nrPDB Length = 286 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 115/273 (42%), Gaps = 17/273 (6%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 P GS + + +G G F V + N D VAIK I + + ++ I Sbjct: 15 VPRGSLHMVIDP-SELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIE- 71 Query: 76 IKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKY 134 E M + HP +++++ V + I V EF+ G L D + G + Sbjct: 72 ---EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGM 128 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 + + Y V HRDL N L+ N +KVSDFG++ D ++ GT Sbjct: 129 CLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL----DDQYTSSTGT 184 Query: 195 P---NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EF 249 + +PEV + Y +K+D+WS GV+++ + + G +P+E+ + + + + I Sbjct: 185 KFPVKWASPEVFSFSRY-SSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 243 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 P S +++ P R F+ ++ Sbjct: 244 YKPRLASTHVYQIMNHCWKERPEDRPAFSRLLR 276 >3C51-A nrPDB Length = 543 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 130/279 (46%), Gaps = 19/279 (6%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G + R LG G F +V + G A K ++K+++ K K E Sbjct: 182 MGEDWFLDF---RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI 238 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI----SSNGRLKEDEARKYFQQL 138 + + ++ + +KT + V+ + GG++ I N +E A Y Q+ Sbjct: 239 LAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQI 298 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++ +++ H R + +RDLKPEN+LLD +G +++SD GL+ + + GTP ++ Sbjct: 299 VSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT--KTKGYAGTPGFM 356 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPW 254 APE++ + YD + D ++ GV L+ ++A PF E L +++ + T P Sbjct: 357 APELLLGEEYDFS-VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDK 415 Query: 255 FSASAKKLIKRILDPNPATRITFAE-----VIENEWFKK 288 FS ++K + +L +P R+ F + + + F+ Sbjct: 416 FSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRD 454 >3GC0-A nrPDB Length = 329 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 76/328 (23%), Positives = 133/328 (40%), Gaps = 45/328 (13%) Query: 1 MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIK 60 + ++T S + PS +S + +Y LGEGT+ +V A + + VAIK Sbjct: 12 LEAQTQGPGSMSVSAAPSATS------IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIK 65 Query: 61 VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI 120 I E + + RE+S +K ++H N+I + V+ +++ + E+ +L + Sbjct: 66 RIRLEHE-EEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYM 123 Query: 121 SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD-----ANGALKVSDFGL 175 N + + + QLIN V++CHSR HRDLKP+NLLL LK+ DFGL Sbjct: 124 DKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGL 183 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 + T Y PE++ + D+WS I ++ F Sbjct: 184 ARAF--GIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGD 241 Query: 236 NLTSLYKKIFKA------------------EFTCPPWFSASAKKLI------------KR 265 + KIF+ + + P + + K+++ Sbjct: 242 SEIDQLFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA 301 Query: 266 ILDPNPATRITFAEVIENEWFKKGYKAP 293 +L+ +P RI+ +E+ +F P Sbjct: 302 MLEMDPVKRISAKNALEHPYFSHNDFDP 329 >3PVW-A nrPDB Length = 695 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 72/272 (26%), Positives = 133/272 (48%), Gaps = 15/272 (5%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI- 86 + + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 87 --KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 H+R V +RDLKP N+LLD +G +++SD GL+ + + H + GT Y+APEV+ Sbjct: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQ 363 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPF---EDSNLTSLYKKIFKAEFTCPPWFSASAKK 261 + AD +S G +LF L+ G+ PF + + + + P FS + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 262 LIKRILDPNPATRI-----TFAEVIENEWFKK 288 L++ +L + R+ EV E+ +F+ Sbjct: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 >5X5O-A nrPDB Length = 310 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 115/267 (43%), Gaps = 23/267 (8%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S + + + G G+F V A+ + VA+K + K I++E Sbjct: 8 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAE 56 Query: 82 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLI 139 + ++ H N+I+ + V+ V E+ + G L+D I+SN + D + + Sbjct: 57 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 116 Query: 140 NAVDYCHSR---GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 + Y H V HRDLK N+++ A+G LK+ DFG S + GT Sbjct: 117 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTH----MSLVGTFP 172 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK--AEFTCPPW 254 ++APEVI + D +S GV+L+ ++ +PF+ + + + T P Sbjct: 173 WMAPEVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 231 Query: 255 FSASAKKLIKRILDPNPATRITFAEVI 281 S +L+ + + + R +F ++I Sbjct: 232 CPRSFAELLHQCWEADAKKRPSFKQII 258 >1LUF-A nrPDB Length = 343 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 110/299 (36%), Gaps = 36/299 (12%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARN-----VENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 E R +GEG F +V AR E VA+K++ +E M A +RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEE--ASADMQADFQRE 100 Query: 80 ISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS----------------- 122 + M +PN++++ V A + + E++ G+L + + S Sbjct: 101 AALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 123 -------NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 L E +Q+ + Y R HRDL N L+ N +K++DFGL Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-AGYLPFED 234 S ++ PE I Y ++D+W+ GV+L+ + G P+ Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 235 SNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + + CP L++ PA R +F + + ++ + Sbjct: 280 MAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI--HRILQRMCER 336 >3IO7-A nrPDB Length = 313 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 121/290 (41%), Gaps = 29/290 (10%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVE----NGDNVAIKVIDKEKVLKNK 71 P GS + + + + LG+G F V+ R G+ VA+K + + + Sbjct: 15 VPRGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---QHSTEE 71 Query: 72 MIAQIKREISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVTGGELFDKISSNG-RLKE 128 + +REI +K ++H N+++ V S + + ++E++ G L D + + R+ Sbjct: 72 HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH 131 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + +Y Q+ ++Y ++ HRDL N+L++ +K+ DFGL+ + Q +E + Sbjct: 132 IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV 191 Query: 189 HTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMA-----GYLP--F------ED 234 +P + APE + + +D+WS GV+L+ L P F + Sbjct: 192 KEPGESPIFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDK 250 Query: 235 SNLTSLYKKIF----KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 ++ I P ++ + N R +F ++ Sbjct: 251 QGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >6DBM-A nrPDB Length = 318 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 117/277 (42%), Gaps = 28/277 (10%) Query: 29 GKY-ELGRTLGEGTFAKVKFA----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 +Y + R LGEG F KV N G+ VA+K + + + + K+EI + Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD--AGPQHRSGWKQEIDIL 87 Query: 84 KLIKHPNVIRMFEVMASKT--KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 + + H ++I+ + V+E+V G L D + + + + + QQ+ Sbjct: 88 RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEG 146 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAP 200 + Y HS+ HRDL N+LLD + +K+ DFGL+ + E + +P + AP Sbjct: 147 MAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP 206 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG-----YLP--F--------EDSNLTSLYKKIF 245 E + + A +D+WS GV L+ L+ P F + L + + Sbjct: 207 ECLKEYKFYYA-SDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLE 265 Query: 246 KAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + E P A L+K + + R TF +I Sbjct: 266 RGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLI 302 >3FI2-A nrPDB Length = 353 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 123/313 (39%), Gaps = 56/313 (17%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 T + +Y+ + +G G V A + NVAIK + + + RE+ MK Sbjct: 21 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 79 Query: 86 IKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 + H N+I + V + +Y V+E + L I L + Q++ Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQML 136 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y A Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRA 193 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK------------- 246 PEVI GY D+WS G I+ ++ + F + + K+ + Sbjct: 194 PEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252 Query: 247 --------------AEFTCPPWFSAS---------------AKKLIKRILDPNPATRITF 277 A T P F S A+ L+ ++L +PA RI+ Sbjct: 253 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312 Query: 278 AEVIENEWFKKGY 290 + +++ + Y Sbjct: 313 DDALQHPYINVWY 325 >3KRL-A nrPDB Length = 335 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 107/274 (39%), Gaps = 28/274 (10%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN-----VAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + G+TLG G F KV A G VA+K++ K + E+ M + Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIMSHL 106 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------------LKED 129 +H N++ + + + E+ G+L + + L Sbjct: 107 GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSR 166 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 + + Q+ + + S+ HRD+ N+LL K+ DFGL+ + Sbjct: 167 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 226 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE 248 ++APE I + Y ++D+WS G++L+ + + G P+ + S + K+ K Sbjct: 227 NARLPVKWMAPESIFDCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDG 285 Query: 249 FTC--PPWFSASAKKLIKRILDPNPATRITFAEV 280 + P + + +++ P R TF ++ Sbjct: 286 YQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >4HZS-A nrPDB Length = 341 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 108/257 (42%), Gaps = 10/257 (3%) Query: 29 GKYELGRTLGEGTFAKVKFAR-NVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKL 85 L LG+G+F V+ + +G V A+K + + + + + + RE++ M Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDY 144 + H N+IR++ V+ + + V E G L D++ + G +Y Q+ + Y Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 130 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVI 203 S+ HRDL NLLL +K+ DFGL Q + ++ P + APE + Sbjct: 131 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK--AEFTCPPWFSASAK 260 + + +D W GV L+ + G P+ N + + KI K P Sbjct: 191 KTRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 249 Query: 261 KLIKRILDPNPATRITF 277 ++ + P R TF Sbjct: 250 NVMVQCWAHKPEDRPTF 266 >4BGQ-A nrPDB Length = 304 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 116/293 (39%), Gaps = 35/293 (11%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + K+E+ +GEG + V R+ E + VAIK K+ ++ RE+ ++ + Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTL 68 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 K N++ + E + K+Y V E+V L + ++ + Y QLI A+ +CH Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 128 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 206 + HRD+KPENLL+ N LK+ DFG + + + T Y +PE++ Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE-GNNANYDEEVATRWYRSPELLLGA 187 Query: 207 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK------ 260 Y G D+WS G IL L G F + I K P Sbjct: 188 PY-GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH 246 Query: 261 --------------------------KLIKRILDPNPATRITFAEVIENEWFK 287 L+K +L +PA R + + + F+ Sbjct: 247 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3BBT-B nrPDB Length = 328 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 135/330 (40%), Gaps = 30/330 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNV----AIKVIDKEKVLKNKMIAQIKREISTMKL 85 + + + LG G F V V G+ V AIK++++ K + + E M Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMAS 73 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDY 144 + HP+++R+ V S T I V + + G L + + + + + Q+ + Y Sbjct: 74 MDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMY 132 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 R + HRDL N+L+ + +K++DFGL+ L + ++ ++A E I+ Sbjct: 133 LEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKL 262 + + ++D+WS GV ++ LM G P++ + + K E PP + + Sbjct: 193 YRKF-THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMV 251 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF------ENADVSLDDVDAIFDDSGESK 316 + + + +R F E+ E+ + ++ + + + F + + + Sbjct: 252 MVKCWMIDADSRPKFKELAA-EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE 310 Query: 317 NLVVERREEGLKTPVTMNAFELISTSQGLN 346 +L M+A E + Q N Sbjct: 311 DLED-----------MMDAEEYL-VPQAFN 328 >3CJF-A nrPDB Length = 309 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 116/298 (38%), Gaps = 26/298 (8%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFA----RNVE-NGDNVAIKVI 62 P +S R + LG+ LG G F +V A + VA+K++ Sbjct: 7 PLDEHCERLPYDASKWEFPR-DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML 65 Query: 63 DKEKVLKNKMIAQIKREISTM-KLIKHPNVIRMFEVMA-SKTKIYFVLEFVTGGELFDKI 120 + + + E+ + + H NV+ + + ++EF G L + Sbjct: 66 K--EGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 123 Query: 121 SSNG------------RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL 168 S L + Y Q+ +++ SR HRDL N+LL + Sbjct: 124 RSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVV 183 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA- 227 K+ DFGL+ + + ++APE I ++ Y ++D+WS GV+L+ + + Sbjct: 184 KICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVY-TIQSDVWSFGVLLWEIFSL 242 Query: 228 GYLPFEDSNLTSLYKKIFKA--EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 G P+ + + + K P + + + + P+ R TF+E++E+ Sbjct: 243 GASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >4PDO-A nrPDB Length = 299 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 119/286 (41%), Gaps = 14/286 (4%) Query: 4 RTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNV-ENGDN---VAI 59 + + P+++ ++ + V + + +G G F +V +G VAI Sbjct: 12 QDPHTYEDPNQAVLKFTTEIHPSCVTR---QKVIGAGEFGEVYKGMLKTSSGKKEVPVAI 68 Query: 60 KVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK 119 K + K E M H N+IR+ V++ + + E++ G L Sbjct: 69 KTLKAG--YTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKF 126 Query: 120 IS-SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL 178 + +G + + + + Y + HRDL N+L+++N KVSDFGLS + Sbjct: 127 LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 186 Query: 179 PQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSN 236 + E + P + APE I+ + + A +D+WS G++++ + G P+ + + Sbjct: 187 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSA-SDVWSFGIVMWEVMTYGERPYWELS 245 Query: 237 LTSLYKKIFKA-EFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + K I P ++ +L+ + A R FA+++ Sbjct: 246 NHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIV 291 >6BSD-A nrPDB Length = 876 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 113/324 (34%), Gaps = 54/324 (16%) Query: 15 STPSGSSSGGRTRVG----KYELGRTLGEGTFAKVKFAR--------------NVENGDN 56 + P G+ G RV + LGEG F +V NV G Sbjct: 553 ALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHP 612 Query: 57 --VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGG 114 VA+K++ + +E+ M +K PN+IR+ V + + +++ G Sbjct: 613 LLVAVKILRPD--ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENG 670 Query: 115 ELFDKISSNG-------------------RLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 +L +S++ + Q+ + + Y + HRDL Sbjct: 671 DLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDL 730 Query: 156 KPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADL 215 N L+ N +K++DFG+S + ++A E I + A +D+ Sbjct: 731 ATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTA-SDV 789 Query: 216 WSCGVILFV--LMAGYLPFEDSNLTSLYKKI--------FKAEFTCPPWFSASAKKLIKR 265 W+ GV L+ ++ PF + + + + PP +L+ R Sbjct: 790 WAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLR 849 Query: 266 ILDPNPATRITFAEVIENEWFKKG 289 R F+++ + + + Sbjct: 850 CWSRESEQRPPFSQL--HRFLAED 871 >5HI2-A nrPDB Length = 283 Score = 235 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 123/273 (45%), Gaps = 19/273 (6%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 SS G+ +G+ +G G+F V + + VA+K++ + + K Sbjct: 9 RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFK 59 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQ 136 E+ ++ +H N++ +F ++K ++ V ++ G L+ + S + + + + Sbjct: 60 NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIAR 118 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 Q +DY H++ + HRDLK N+ L + +K+ DFGL+ + + G+ Sbjct: 119 QTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 178 Query: 197 YVAPEVI--NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL-TSLYKKIFKAEFTC-- 251 ++APEVI + ++D+++ G++L+ LM G LP+ + N + + + + + Sbjct: 179 WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDL 238 Query: 252 ---PPWFSASAKKLIKRILDPNPATRITFAEVI 281 K+L+ L R +F ++ Sbjct: 239 SKVRSNCPKRMKRLMAECLKKKRDERPSFPRIL 271 >1U54-B nrPDB Length = 291 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 108/257 (42%), Gaps = 10/257 (3%) Query: 29 GKYELGRTLGEGTFAKVKFAR-NVENGDNV--AIKVIDKEKVLKNKMIAQIKREISTMKL 85 L LG+G+F V+ + +G V A+K + + + + + + RE++ M Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDY 144 + H N+IR++ V+ + + V E G L D++ + G +Y Q+ + Y Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 136 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVI 203 S+ HRDL NLLL +K+ DFGL Q + ++ P + APE + Sbjct: 137 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 196 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK--AEFTCPPWFSASAK 260 + + +D W GV L+ + G P+ N + + KI K P Sbjct: 197 KTRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 255 Query: 261 KLIKRILDPNPATRITF 277 ++ + P R TF Sbjct: 256 NVMVQCWAHKPEDRPTF 272 >3MIA-A nrPDB Length = 351 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 127/305 (41%), Gaps = 49/305 (16%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 V KYE +G+GTF +V AR+ + G VA+K + E K REI ++L+ Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLL 73 Query: 87 KHPNVIRMFEVMASK--------TKIYFVLEFVTG---GELFDKISSNGRLKEDEARKYF 135 KH NV+ + E+ +K IY V +F G L + + E ++ Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVM 130 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ--QVREDGLLHTTCG 193 Q L+N + Y H + HRD+K N+L+ +G LK++DFGL+ + + Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL----------------------P 231 T Y PE++ + G DLW G I+ + P Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 232 --FEDSNLTSLYKKI-------FKAEFTCPPWF-SASAKKLIKRILDPNPATRITFAEVI 281 + + + LY+K+ K + + A LI ++L +PA RI + + Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Query: 282 ENEWF 286 +++F Sbjct: 311 NHDFF 315 >3HMP-A nrPDB Length = 342 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 132/298 (44%), Gaps = 20/298 (6%) Query: 6 TPSRSTPSRSTPSGSSSGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK 64 +P T S S++ + G+ Y + + +G G +KV N E AIK ++ Sbjct: 32 SPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNL 90 Query: 65 EKVLKNKMIAQIKREISTMKLIK--HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 E+ N+ + + EI+ + ++ +IR+++ + IY V+E +L + Sbjct: 91 EEA-DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK 148 Query: 123 NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 + E + Y++ ++ AV H G+ H DLKP N L+ +G LK+ DFG++ Q Sbjct: 149 KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD 207 Query: 183 REDGLLHTTCGTPNYVAPEVINNKG----------YDGAKADLWSCGVILFVLMAGYLPF 232 + + GT NY+ PE I + K+D+WS G IL+ + G PF Sbjct: 208 TTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 Query: 233 ED-SNLTSLYKKIF--KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + N S I E P + ++K L +P RI+ E++ + + + Sbjct: 268 QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >3LM0-A nrPDB Length = 327 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 77/277 (27%), Positives = 129/277 (46%), Gaps = 15/277 (5%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH-PNVIR 93 + LG G FA V+ + G A K + K + ++ A+I EI+ ++L K P VI Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD-CRAEILHEIAVLELAKSCPRVIN 93 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRGVY 151 + EV + ++I +LE+ GGE+F + E++ + +Q++ V Y H + Sbjct: 94 LHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIV 153 Query: 152 HRDLKPENLLLDAN---GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 H DLKP+N+LL + G +K+ DFG+S ++ L GTP Y+APE++N Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSR---KIGHACELREIMGTPEYLAPEILNYDPI 210 Query: 209 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW----FSASAKKLIK 264 A D+W+ G+I ++L+ PF + Y I + S A I+ Sbjct: 211 TTA-TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQ 269 Query: 265 RILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS 301 +L NP R T + + W ++ F + S Sbjct: 270 SLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETS 306 >5HIE-A nrPDB Length = 302 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 122/273 (44%), Gaps = 19/273 (6%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 SS G+ +G+ +G G+F V + + VA+K++ + + K Sbjct: 25 RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFK 75 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQ 136 E+ ++ +H N++ +F ++K ++ V ++ G L+ + + + + + Sbjct: 76 NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIAR 134 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 Q +DY H++ + HRDLK N+ L + +K+ DFGL+ + + G+ Sbjct: 135 QTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 194 Query: 197 YVAPEVI--NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP- 253 ++APEVI +K ++D+++ G++L+ LM G LP+ + N + + P Sbjct: 195 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDL 254 Query: 254 -----WFSASAKKLIKRILDPNPATRITFAEVI 281 + K+L+ L R F +++ Sbjct: 255 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >5AMN-A nrPDB Length = 299 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 111/268 (41%), Gaps = 20/268 (7%) Query: 33 LGRTLGEGTFAKVKFARNVENG-----DNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LG+TLGEG F KV A VA+K++ + + + E + +K + Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK--ENASPSELRDLLSEFNVLKQVN 84 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------LKEDEARKYFQQ 137 HP+VI+++ + + ++E+ G L + + + L + + Q Sbjct: 85 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQ 144 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + + Y + HRDL N+L+ +K+SDFGLS + + Sbjct: 145 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW 204 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWF 255 +A E + + Y ++D+WS GV+L+ ++ G P+ L+ + P Sbjct: 205 MAIESLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC 263 Query: 256 SASAKKLIKRILDPNPATRITFAEVIEN 283 S +L+ + P R FA++ ++ Sbjct: 264 SEEMYRLMLQCWKQEPDKRPVFADISKD 291 >4R7H-A nrPDB Length = 343 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 109/281 (38%), Gaps = 35/281 (12%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDN-----VAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 + G+TLG G F KV A G VA+K++ K + E+ M + Sbjct: 53 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEK--EALMSELKIMSHL 110 Query: 87 -KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN---------------------- 123 +H N++ + + + E+ T G+L + + Sbjct: 111 GQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKED 170 Query: 124 -GRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 L+ + + Q+ + + S+ HRD+ N+LL K+ DFGL+ Sbjct: 171 GRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND 230 Query: 183 REDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLY 241 + ++APE I + Y ++D+WS G++L+ + + G P+ + S + Sbjct: 231 SNYIVKGNARLPVKWMAPESIFDSVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 289 Query: 242 KKIFKAEFTC--PPWFSASAKKLIKRILDPNPATRITFAEV 280 K+ K + P + + +++ P R TF ++ Sbjct: 290 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >5G6V-A nrPDB Length = 324 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 125/299 (41%), Gaps = 40/299 (13%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 Y LGEGT+A V ++ + VA+K I E + RE+S +K +KH N Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH--EEGAPCTAIREVSLLKDLKHAN 61 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRL-KEDEARKYFQQLINAVDYCHSRG 149 ++ + +++ ++ + V E++ +L + G + + + QL+ + YCH + Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 120 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 V HRDLKP+NLL++ G LK++DFGL+ + T Y P+++ Sbjct: 121 VLHRDLKPQNLLINERGELKLADFGLARA--KSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA-------------------EFT 250 + D+W G I + + G F S + IF+ + Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 251 CP-----------PWFSASAKKLIKRILDPNPATRITFAEVIENEWF----KKGYKAPK 294 P P + L+ ++L RI+ + +++ +F ++ +K P Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPD 297 >6DBN-A nrPDB Length = 316 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 126/298 (42%), Gaps = 35/298 (11%) Query: 13 SRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVE----NGDNVAIKVIDKEKVL 68 S P+ + R LGEG F KV+ R G+ VA+K + E Sbjct: 19 SEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG- 77 Query: 69 KNKMIAQIKREISTMKLIKHPNVIRMFEVMASK--TKIYFVLEFVTGGELFDKISSNG-R 125 IA +K+EI ++ + H N+++ + I ++EF+ G L + + N + Sbjct: 78 -GNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK 136 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 + + KY Q+ +DY SR HRDL N+L+++ +K+ DFGL+ + +E Sbjct: 137 INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEY 196 Query: 186 GLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL---Y 241 + +P + APE + + +D+WS GV L L+ + DS+ + + Sbjct: 197 YTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT----YCDSDSSPMALFL 251 Query: 242 KKIFKAE-----------------FTCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 K I CPP +L+++ + P+ R +F +IE Sbjct: 252 KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >2PL0-A nrPDB Length = 289 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 112/253 (44%), Gaps = 18/253 (7%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 +L LG G F +V VA+K + + + + +A E + MK ++H + Sbjct: 26 KLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSPDAFLA----EANLMKQLQHQRL 80 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKIS--SNGRLKEDEARKYFQQLINAVDYCHSRG 149 +R++ V+ ++ IY + E++ G L D + S +L ++ Q+ + + R Sbjct: 81 VRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVINNK 206 HRDL+ N+L+ + K++DFGL+ L ED G + APE IN Sbjct: 140 YIHRDLRAANILVSDTLSCKIADFGLARLI----EDNEYTAREGAKFPIKWTAPEAINYG 195 Query: 207 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIK 264 + K+D+WS G++L ++ G +P+ + + + + P +L++ Sbjct: 196 TF-TIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR 254 Query: 265 RILDPNPATRITF 277 P R TF Sbjct: 255 LCWKERPEDRPTF 267 >6FEX-A nrPDB Length = 321 Score = 234 bits (597), Expect = 8e-62, Method: Composition-based stats. Identities = 58/315 (18%), Positives = 111/315 (35%), Gaps = 48/315 (15%) Query: 18 SGSSSGGRTRVG----KYELGRTLGEGTFAKVKFAR--------------NVENGDN--V 57 G+ G RV + LGEG F +V NV G V Sbjct: 1 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 60 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+K++ + +E+ M +K PN+IR+ V + + +++ G+L Sbjct: 61 AVKILRPD--ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLN 118 Query: 118 DKISSNG-------------RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA 164 +S++ + Q+ + + Y + HRDL N L+ Sbjct: 119 QFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 178 Query: 165 NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFV 224 N +K++DFG+S + ++A E I + A +D+W+ GV L+ Sbjct: 179 NFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTA-SDVWAFGVTLWE 237 Query: 225 --LMAGYLPFEDSNLTSLYKKI--------FKAEFTCPPWFSASAKKLIKRILDPNPATR 274 ++ PF + + + + PP +L+ R R Sbjct: 238 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 Query: 275 ITFAEVIENEWFKKG 289 F+++ + + + Sbjct: 298 PPFSQL--HRFLAED 310 >3RP9-A nrPDB Length = 458 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 89/378 (23%), Positives = 132/378 (34%), Gaps = 96/378 (25%) Query: 3 SRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI 62 R S P+ S P S +YE+ +G G++ V A + VAIK I Sbjct: 29 QRKQHHSSKPTASMPRPHSDWQIP--DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI 86 Query: 63 DKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKT-----KIYFVLEFVTGGELF 117 +I REI+ + + H +V+++ +++ K ++Y VLE + Sbjct: 87 -LRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFK 144 Query: 118 DKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA 177 + L E + L+ V Y HS G+ HRDLKP N L++ + ++KV DFGL+ Sbjct: 145 KLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLAR 204 Query: 178 -----------LPQQVREDGL--------------LHTTCGTPNYVAPEVINNKGYDGAK 212 LP RED + L T Y APE+I + Sbjct: 205 TVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEA 264 Query: 213 ADLWSCGVILFVLMA-----------GYLPFEDSN--------------------LTSLY 241 D+WS G I L+ F S+ Sbjct: 265 IDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQL 324 Query: 242 KKIFKAEFTCP-------------------------------PWFSASAKKLIKRILDPN 270 IF T P SA A L+KR+L N Sbjct: 325 NVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFN 384 Query: 271 PATRITFAEVIENEWFKK 288 P RIT E + + +FK+ Sbjct: 385 PNKRITINECLAHPFFKE 402 >3A4O-X nrPDB Length = 286 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 111/268 (41%), Gaps = 19/268 (7%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 +L + LG G F +V N VA+K + + + Sbjct: 2 PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYY-NNSTKVAVKTLKPGTMS----VQAFL 56 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYF 135 E + MK ++H ++R++ V+ + IY + E++ G L D + S+ G++ + + Sbjct: 57 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 116 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG-- 193 Q+ + Y + HRDL+ N+L+ + K++DFGL+ + ED G Sbjct: 117 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI----EDNEYTAREGAK 172 Query: 194 -TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTC 251 + APE IN G K+D+WS G++L+ ++ G +P+ + + + + Sbjct: 173 FPIKWTAPEAINF-GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRM 230 Query: 252 P--PWFSASAKKLIKRILDPNPATRITF 277 P ++K R TF Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERPTF 258 >4E20-A nrPDB Length = 290 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 117/277 (42%), Gaps = 28/277 (10%) Query: 29 GKY-ELGRTLGEGTFAKVKFA----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 +Y + R LGEG F KV N G+ VA+K + + ++ + +REI + Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK--EGCGPQLRSGWQREIEIL 64 Query: 84 KLIKHPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 + + H ++++ + + + V+E+V G L D + + + + + QQ+ Sbjct: 65 RTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEG 123 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAP 200 + Y H++ HR L N+LLD + +K+ DFGL+ + E + +P + AP Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP 183 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMA----GYLPF-----------EDSNLTSLYKKIF 245 E + + A +D+WS GV L+ L+ P + L + + Sbjct: 184 ECLKECKFYYA-SDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLE 242 Query: 246 KAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 + E P L+K + + R TF ++ Sbjct: 243 RGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLV 279 >4YFF-A nrPDB Length = 311 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 66/270 (24%), Positives = 110/270 (40%), Gaps = 9/270 (3%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 +G S ++ + E +G G+F KV R VAIK + Sbjct: 31 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFC 88 Query: 78 REISTMKLIKHPNVIRMFEVMA-SKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYF 135 RE+S + + HP VI+ ++ V ++++GG LF + R L Sbjct: 89 REVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 148 Query: 136 QQLINAVDYCH--SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 + ++Y H ++ + HRDL N+LL +G V+DFG S Q + ED + G Sbjct: 149 VDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP-G 207 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP- 252 ++APEV KAD++S + L+ ++ G +PF + + P Sbjct: 208 NLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPI 267 Query: 253 -PWFSASAKKLIKRILDPNPATRITFAEVI 281 L+ R + P R F+EV+ Sbjct: 268 GYSIPKPISSLLIRGWNACPEGRPEFSEVV 297 >4O2Z-A nrPDB Length = 377 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 108/310 (34%), Gaps = 40/310 (12%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 KY L + LG G + + + G+ V+IK + + ++ REI M+ H Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCR-DVFRDVEDGKRVLREIDMMRFFHH 103 Query: 89 PNVIRMFEV-------MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 141 N++ + + S +Y V + ++ + S L+E + + Q++ Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRG 162 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 + Y HS V HRDLKP NL+ + + LK+ DFGLS L T Y PE Sbjct: 163 LKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVD--VPYSELTDYVITRWYRPPE 220 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------ 255 ++ D+WS G I + F N + I + P Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREA 280 Query: 256 -----------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 + + ++ +P+ R T A+++ + + + Sbjct: 281 LEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDE 340 Query: 293 PKFENADVSL 302 Sbjct: 341 EDEPTCPCPF 350 >3G0E-A nrPDB Length = 336 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 110/285 (38%), Gaps = 30/285 (10%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 + G+TLG G F KV A + VA+K++ L + + E Sbjct: 42 EFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTER--EALMSE 99 Query: 80 ISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-------------- 124 + + + H N++ + + E+ G+L + + Sbjct: 100 LKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIME 159 Query: 125 ----RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 L ++ + Q+ + + S+ HRDL N+LL K+ DFGL+ + Sbjct: 160 DDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIK 219 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++APE I N Y ++D+WS G+ L+ L + G P+ + S Sbjct: 220 NDSNYVVKGNARLPVKWMAPESIFNCVY-TFESDVWSYGIFLWELFSLGSSPYPGMPVDS 278 Query: 240 LYKKIFKAEFTC--PPWFSASAKKLIKRILDPNPATRITFAEVIE 282 + K+ K F P A ++K D +P R TF ++++ Sbjct: 279 KFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >2HK5-A nrPDB Length = 270 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 113/257 (43%), Gaps = 20/257 (7%) Query: 32 ELGRTLGEGTFAKVKFA-RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 +L + LG G F +V A N VA+K + + + E + MK ++H Sbjct: 18 KLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMS----VEAFLAEANVMKTLQHDK 71 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCHSR 148 ++++ V+ +K IY + EF+ G L D + S+ + + + Q+ + + R Sbjct: 72 LVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR 130 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG---TPNYVAPEVINN 205 HRDL+ N+L+ A+ K++DFGL+ + ED G + APE IN Sbjct: 131 NYIHRDLRAANILVSASLVCKIADFGLARVI----EDNEYTAREGAKFPIKWTAPEAINF 186 Query: 206 KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLI 263 + K+D+WS G++L ++ G +P+ + + + + + P ++ Sbjct: 187 GSF-TIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 245 Query: 264 KRILDPNPATRITFAEV 280 R P R TF + Sbjct: 246 MRCWKNRPEERPTFEYI 262 >3PP0-A nrPDB Length = 338 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 121/303 (39%), Gaps = 12/303 (3%) Query: 34 GRTLGEGTFAKVKFARNVENGDNV----AIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 + LG G F V + +G+NV AIKV+ + K +I E M + P Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR--ENTSPKANKEILDEAYVMAGVGSP 79 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR 148 V R+ + + T + V + + G L D + N GRL + + Q+ + Y Sbjct: 80 YVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDV 138 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 + HRDL N+L+ + +K++DFGL+ L + ++A E I + + Sbjct: 139 RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF 198 Query: 209 DGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRI 266 ++D+WS GV ++ LM G P++ + + K E PP + ++ + Sbjct: 199 -THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC 257 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEG 326 + R F E++ E+ + +F + D + L + + Sbjct: 258 WMIDSECRPRFRELVS-EFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDL 316 Query: 327 LKT 329 + Sbjct: 317 VDA 319 >2ZMD-A nrPDB Length = 390 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 131/298 (43%), Gaps = 20/298 (6%) Query: 6 TPSRSTPSRSTPSGSSSGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDK 64 +P T S S++ + G+ Y + + +G G +KV N E AIK ++ Sbjct: 32 SPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNL 90 Query: 65 EKVLKNKMIAQIKREISTMKLIK--HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS 122 E+ N+ + + EI+ + ++ +IR+++ + IY V+E +L + Sbjct: 91 EEA-DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK 148 Query: 123 NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 + E + Y++ ++ AV H G+ H DLKP N L+ +G LK+ DFG++ Q Sbjct: 149 KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD 207 Query: 183 REDGLLHTTCGTPNYVAPEVINNKG----------YDGAKADLWSCGVILFVLMAGYLPF 232 + + G NY+ PE I + K+D+WS G IL+ + G PF Sbjct: 208 TTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 Query: 233 ED-SNLTSLYKKIF--KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + N S I E P + ++K L +P RI+ E++ + + + Sbjct: 268 QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >1AD5-A nrPDB Length = 438 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 113/275 (41%), Gaps = 24/275 (8%) Query: 11 TPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFA-RNVENGDNVAIKVIDKEKVLK 69 S+ +L + LG G F +V A N VA+K + + Sbjct: 164 MSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMS- 220 Query: 70 NKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLK 127 + E + MK ++H ++++ V+ +K IY + EF+ G L D + S+ + Sbjct: 221 ---VEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQP 276 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGL 187 + + Q+ + + R HRDL+ N+L+ A+ K++DFGL+ + + Sbjct: 277 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKF----- 331 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK 246 + APE IN + K+D+WS G++L ++ G +P+ + + + + + Sbjct: 332 ------PIKWTAPEAINFGSF-TIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER 384 Query: 247 A-EFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 P ++ R P R TF + Sbjct: 385 GYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYI 419 >6GVJ-A nrPDB Length = 429 Score = 231 bits (589), Expect = 6e-61, Method: Composition-based stats. Identities = 72/288 (25%), Positives = 129/288 (44%), Gaps = 20/288 (6%) Query: 16 TPSGSSSGGRTRVGK-YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 S S++ + G+ Y + + +G G +KV N E AIK ++ E+ N+ + Sbjct: 130 LASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLD 187 Query: 75 QIKREISTMKLIK--HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR 132 + EI+ + ++ +IR+++ + IY V+E +L + + E + Sbjct: 188 SYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERK 246 Query: 133 KYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC 192 Y++ ++ AV H G+ H DLKP N L+ +G LK+ DFG++ Q + + Sbjct: 247 SYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQV 305 Query: 193 GTPNYVAPEVINNKG----------YDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLY 241 GT NY+ PE I + K+D+WS G IL+ + G PF+ N S Sbjct: 306 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKL 365 Query: 242 KKIF--KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 I E P + ++K L +P RI+ E++ + + + Sbjct: 366 HAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >3LZB-A nrPDB Length = 327 Score = 230 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 119/273 (43%), Gaps = 12/273 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNV----AIKVIDKEKVLKNKMIAQIKREISTMKL 85 +++ + LG G F V + G+ V AIK + + K +I E M Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR--EATSPKANKEILDEAYVMAS 73 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDY 144 + +P+V R+ + + T + + + + G L D + + + + Q+ ++Y Sbjct: 74 VDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 132 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 R + HRDL N+L+ +K++DFGL+ L ++ ++A E I Sbjct: 133 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKL 262 ++ Y ++D+WS GV ++ LM G P++ + + + K E PP + + Sbjct: 193 HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMI 251 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 +++ + +R F E+I E+ K ++ Sbjct: 252 MRKCWMIDADSRPKFRELII-EFSKMARDPQRY 283 >4XUF-A nrPDB Length = 297 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 110/288 (38%), Gaps = 35/288 (12%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGD--NVAIKVIDKEKVLKNKMIAQIKRE 79 E G+ LG G F KV A + G VA+K++ ++ + + E Sbjct: 5 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSE 62 Query: 80 ISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEA------ 131 + M + H N++ + IY + E+ G+L + + + EDE Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQK 122 Query: 132 ----------------RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 + Q+ +++ + HRDL N+L+ +K+ DFGL Sbjct: 123 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 182 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFED 234 + + ++APE + G K+D+WS G++L+ + + G P+ Sbjct: 183 ARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 241 Query: 235 SNLTSLYKKIFKAEFTC--PPWFSASAKKLIKRILDPNPATRITFAEV 280 + + + K+ + F P + + +++ + R +F + Sbjct: 242 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >5GNK-A nrPDB Length = 297 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 119/273 (43%), Gaps = 12/273 (4%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNV----AIKVIDKEKVLKNKMIAQIKREISTMKL 85 +++ + LG G F V + G+ V AIK + + K +I E M Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR--EATSPKANKEILDEAYVMAS 77 Query: 86 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDY 144 + +P+V R+ + + T + +++ + G L D + + + + Q+ ++Y Sbjct: 78 VDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 136 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 R + HRDL N+L+ +K++DFGL+ L ++ ++A E I Sbjct: 137 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKL 262 ++ Y ++D+WS GV ++ LM G P++ + + + K E PP + + Sbjct: 197 HRIY-THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMI 255 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 + + + +R F E+I E+ K ++ Sbjct: 256 MVKCWMIDADSRPKFRELII-EFSKMARDPQRY 287 >5O2B-A nrPDB Length = 285 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 125/274 (45%), Gaps = 19/274 (6%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 R K+++ LG G F V + E VA + K+ K + + K E +K + Sbjct: 16 RFLKFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGL 72 Query: 87 KHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +HPN++R ++ S K I V E +T G L + +K R + +Q++ + Sbjct: 73 QHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGL 132 Query: 143 DYCHSR--GVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + H+R + HRDLK +N+ + G++K+ D GL+ L + + GTP ++A Sbjct: 133 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR----TSFAKSVIGTPEFMA 188 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKA--EFTCPPWFS 256 PE+ + D+++ G+ + + P+ E N +Y+K+ + Sbjct: 189 PEMYEE--HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTD 246 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 K++I+ + N + R++ +++ + +F + Sbjct: 247 PEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >5FM2-A nrPDB Length = 355 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 111/282 (39%), Gaps = 34/282 (12%) Query: 33 LGRTLGEGTFAKVKFARNVENG-----DNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LG+TLGEG F KV A VA+K++ + + + E + +K + Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK--ENASPSELRDLLSEFNVLKQVN 125 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR---------------------- 125 HP+VI+++ + + ++E+ G L + + + Sbjct: 126 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 185 Query: 126 --LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVR 183 L + + Q+ + Y + HRDL N+L+ +K+SDFGLS + Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 245 Query: 184 EDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYK 242 ++A E + + Y ++D+WS GV+L+ ++ G P+ L+ Sbjct: 246 SYVKRSQGRIPVKWMAIESLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN 304 Query: 243 KIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + P S +L+ + P R FA++ ++ Sbjct: 305 LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 >6E4F-A nrPDB Length = 290 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 117/261 (44%), Gaps = 16/261 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 + LG G F VK+ + D VAIK+I + + +++ I E M + H Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIE----EAKVMMNLSH 85 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHS 147 +++++ V + I+ + E++ G L + + R + + + + + A++Y S Sbjct: 86 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 145 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVIN 204 + HRDL N L++ G +KVSDFGLS D ++ G+ + PEV+ Sbjct: 146 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL----DDEYTSSVGSKFPVRWSPPEVLM 201 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWF-SASAKKL 262 + +K+D+W+ GV+++ + + G +P+E + + I + P S + Sbjct: 202 YSKF-SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 260 Query: 263 IKRILDPNPATRITFAEVIEN 283 + R TF ++ N Sbjct: 261 MYSCWHEKADERPTFKILLSN 281 >2W96-B nrPDB Length = 306 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 126/303 (41%), Gaps = 43/303 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK- 87 +YE +G G + V AR+ +G VA+K + + I+ + RE++ ++ ++ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTV-REVALLRRLEA 62 Query: 88 --HPNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQL 138 HPNV+R+ +V A+ K+ V E V +L + L + + +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 + +D+ H+ + HRDLKPEN+L+ + G +K++DFGL+ + L T Y Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALDPVVVTLWYR 178 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP------ 252 APEV+ Y D+WS G I + F ++ KIF P Sbjct: 179 APEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 237 Query: 253 ---------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 291 P S +L+ +L NP RI+ +++ + K Sbjct: 238 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 297 Query: 292 APK 294 P+ Sbjct: 298 NPE 300 >5GRN-A nrPDB Length = 356 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 111/289 (38%), Gaps = 41/289 (14%) Query: 33 LGRTLGEGTFAKVKFARNVENGD-----NVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LGR LG G F KV VA+K++ K + E+ M + Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQA--LMSELKIMTHLG 107 Query: 88 -HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG---------------------- 124 H N++ + IY + E+ G+L + + N Sbjct: 108 PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSD 167 Query: 125 ----RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQ 180 L + + Q+ +++ S+ HRDL N+LL +K+ DFGL+ Sbjct: 168 DNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIM 227 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 +T ++APE I + Y +D+WS G++L+ + + G P+ + S Sbjct: 228 HDSNYVSKGSTFLPVKWMAPESIFDNLYTTL-SDVWSYGILLWEIFSLGGTPYPGMMVDS 286 Query: 240 L-YKKIFKA-EFTCPPWFSASAKKLIKRILDPNPATRITF---AEVIEN 283 Y KI P ++ +++ + + P R +F +E++EN Sbjct: 287 TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 335 >5X02-A nrPDB Length = 347 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 53/288 (18%), Positives = 110/288 (38%), Gaps = 35/288 (12%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGD--NVAIKVIDKEKVLKNKMIAQIKRE 79 E G+ LG G F KV A + G VA+K++ ++ + + E Sbjct: 44 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSE 101 Query: 80 ISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEA------ 131 + M + H N++ + IY + E+ G+L + + + EDE Sbjct: 102 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQK 161 Query: 132 ----------------RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 + Q+ +++ + HRDL N+L+ +K+ DFGL Sbjct: 162 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 221 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFED 234 + + ++APE + G K+D+WS G++L+ + + G P+ Sbjct: 222 ARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 280 Query: 235 SNLTSLYKKIFKA--EFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 + + + K+ + + P + + +++ + R +F + Sbjct: 281 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >4Y93-A nrPDB Length = 446 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 118/261 (45%), Gaps = 16/261 (6%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 + LG G F VK+ + D VAIK+I + + +++ I E M + H Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIE----EAKVMMNLSH 242 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHS 147 +++++ V + I+ + E++ G L + + R + + + + + A++Y S Sbjct: 243 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 302 Query: 148 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVIN 204 + HRDL N L++ G +KVSDFG++ D ++ G+ + +PEV+ Sbjct: 303 KQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVL----DDEYTSSTGSKFPVKWASPEVLM 358 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKL 262 + +K+D+W+ GV+++ + + G +P+E + + I + P S + Sbjct: 359 YSKF-SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAI 417 Query: 263 IKRILDPNPATRITFAEVIEN 283 + R TF ++ N Sbjct: 418 MYSCWHEKADERPTFKILLSN 438 >5U6B-A nrPDB Length = 307 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 111/267 (41%), Gaps = 18/267 (6%) Query: 33 LGRTLGEGTFAKVKFARNVENGD--NVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 LG+TLGEG F V + ++ VA+K + K + + E MK HPN Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELEDFLSEAVCMKEFDHPN 85 Query: 91 VIRMFEVMASKTKI------YFVLEFVTGGELFDKI------SSNGRLKEDEARKYFQQL 138 V+R+ V ++ +L F+ G+L + L K+ + Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 + ++Y ++ HRDL N +L+ N ++ V+DFGLS ++ Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFS 256 A E + ++ Y K+D+WS GV ++ + G P+ + +Y + + P Sbjct: 206 AIESLADRVYTS-KSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCL 264 Query: 257 ASAKKLIKRILDPNPATRITFAEVIEN 283 L+ R + NP R +F E+ E+ Sbjct: 265 DGLYALMSRCWELNPQDRPSFTELRED 291 >5O2C-A nrPDB Length = 380 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 125/274 (45%), Gaps = 19/274 (6%) Query: 27 RVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 R K+++ LG G F V + E VA + K+ K + + K E +K + Sbjct: 25 RFLKFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGL 81 Query: 87 KHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 142 +HPN++R ++ S K I V E +T G L + +K R + +Q++ + Sbjct: 82 QHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGL 141 Query: 143 DYCHSR--GVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 + H+R + HRDLK +N+ + G++K+ D GL+ L + + GTP ++A Sbjct: 142 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR----TSFAKSVIGTPEFMA 197 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKA--EFTCPPWFS 256 PE+ + D+++ G+ + + P+ E N +Y+K+ + Sbjct: 198 PEMYEE--HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTD 255 Query: 257 ASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 290 K++I+ + N + R++ +++ + +F + Sbjct: 256 PEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >5HLW-A nrPDB Length = 299 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 113/260 (43%), Gaps = 14/260 (5%) Query: 32 ELGRTLGEGTFAKVKFARNVEN---GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +G G F V ++N + A+K ++ ++ ++Q E MK H Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSH 80 Query: 89 PNVIRMFEVM-ASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCH 146 PNV+ + + S+ VL ++ G+L + I + + + Q+ + Y Sbjct: 81 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVI 203 S+ HRDL N +LD +KV+DFGL+ +E +H G ++A E + Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHD-KEYYSVHNKTGAKLPVKWMALESL 199 Query: 204 NNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTC-PPWFSASAKK 261 + + K+D+WS GV+L+ LM G P+ D N + + + P + + Sbjct: 200 QTQKFTT-KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 258 Query: 262 LIKRILDPNPATRITFAEVI 281 ++ + P R +F+E++ Sbjct: 259 VMLKCWHPKAEMRPSFSELV 278 >2W1I-A nrPDB Length = 326 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 57/276 (20%), Positives = 116/276 (42%), Gaps = 29/276 (10%) Query: 30 KYELGRTLGEGTFAKVKFARNVE----NGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 85 + + LG+G F V+ R G+ VA+K + + + + +REI +K Sbjct: 42 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---QHSTEEHLRDFEREIEILKS 98 Query: 86 IKHPNVIRMFEVMAS--KTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAV 142 ++H N+++ V S + + ++E++ G L D + + R+ + +Y Q+ + Sbjct: 99 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 158 Query: 143 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPE 201 +Y ++ HRDL N+L++ +K+ DFGL+ + Q +E + +P + APE Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 202 VINNKGYDGAKADLWSCGVILFVLMA-----GYLP--F------EDSNLTSLYKKIF--- 245 + + +D+WS GV+L+ L P F + ++ I Sbjct: 219 SLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 277 Query: 246 -KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 P ++ + N R +F ++ Sbjct: 278 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3OMV-A nrPDB Length = 307 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 117/273 (42%), Gaps = 14/273 (5%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 SS + L +G G+F V + + VA+K++ + A + Sbjct: 25 RDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQA-FR 80 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQ 136 E++ ++ +H N++ +F +K + V ++ G L+ + + + + + Sbjct: 81 NEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR 139 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 Q +DY H++ + HRD+K N+ L +K+ DFGL+ + + + G+ Sbjct: 140 QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL 199 Query: 197 YVAPEVINNKGYD--GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP- 253 ++APEVI + + ++D++S G++L+ LM G LP+ N + + P Sbjct: 200 WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDL 259 Query: 254 -----WFSASAKKLIKRILDPNPATRITFAEVI 281 + K+L+ + R F +++ Sbjct: 260 SKLYKNCPKAMKRLVADCVKKVKEERPLFPQIL 292 >3ORP-A nrPDB Length = 311 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 127/265 (47%), Gaps = 11/265 (4%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YELG LG G ++V AR++ + +VA+KV+ + + +RE + H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 89 PNVIRMFEVMASKTKI----YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144 P ++ +++ ++T Y V+E+V G L D + + G + A + A+++ Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNF 131 Query: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCGTPNYVAPEVI 203 H G+ HRD+KP N+++ A A+KV DFG++ + GT Y++PE Sbjct: 132 SHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQA 191 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL-YKKIFKAEFTCP---PWFSASA 259 D A++D++S G +L+ ++ G PF + S+ Y+ + + SA Sbjct: 192 RGDSVD-ARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADL 250 Query: 260 KKLIKRILDPNPATRI-TFAEVIEN 283 ++ + L NP R T AE+ + Sbjct: 251 DAVVLKALAKNPENRYQTAAEMRAD 275 >2I6L-A nrPDB Length = 320 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 123/304 (40%), Gaps = 51/304 (16%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y + LG G V A + + VAIK I + + + REI ++ + H Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDH 67 Query: 89 PNVIRMFEVMASK--------------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 N++++FE++ +Y V E++ +L + + G L E+ AR + Sbjct: 68 DNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVL-EQGPLLEEHARLF 125 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLD-ANGALKVSDFGLSALPQ-QVREDGLLHTTC 192 QL+ + Y HS V HRDLKP NL ++ + LK+ DFGL+ + G L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF------- 245 T Y +P ++ + D+W+ G I ++ G F ++ + I Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 246 ---------------KAEFTCP--------PWFSASAKKLIKRILDPNPATRITFAEVIE 282 + + T P P S A +++IL +P R+T E + Sbjct: 246 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALS 305 Query: 283 NEWF 286 + + Sbjct: 306 HPYM 309 >4YHJ-A nrPDB Length = 584 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 73/265 (27%), Positives = 124/265 (46%), Gaps = 15/265 (5%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 R LG+G F +V + G A K + K+++ K K A E ++ ++ V+ + Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 +K + VL + GG+L I + N E A Y +L ++ + + Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RDLKPEN+LLD G +++SD GL+ ++ E + GT Y+APEV+NN+ Y + Sbjct: 311 RDLKPENILLDDRGHIRISDLGLAT---EIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSP 367 Query: 213 ADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 D W G +++ ++ G+ PF E + ++I FS AK + + +L Sbjct: 368 -DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLT 426 Query: 269 PNPATRI-----TFAEVIENEWFKK 288 NP+ R+ A V ++ FK Sbjct: 427 KNPSKRLGCRGEGAAGVKQHPVFKD 451 >4E7W-A nrPDB Length = 394 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 85/320 (26%), Positives = 132/320 (41%), Gaps = 52/320 (16%) Query: 8 SRSTPSRSTPSGSSSG--GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE 65 P++ +S G G R Y + +G G+F V A+ VE+ D VAIK + ++ Sbjct: 17 PLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVES-DEVAIKKVLQD 75 Query: 66 KVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTK------IYFVLEFVT---GGEL 116 K KN RE+ M+++KHPNV+ + S + VLE+V Sbjct: 76 KRFKN-------RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRAS 128 Query: 117 FDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-NGALKVSDFGL 175 + + Y QL+ ++ Y HS G+ HRD+KP+NLLLD +G LK+ DFG Sbjct: 129 RHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGS 188 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 + + + + + Y APE+I D+WS G ++ LM G F Sbjct: 189 AKILIAGEPN---VSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGE 245 Query: 236 NLTSLYKKIFKA-----------------EFTCP------------PWFSASAKKLIKRI 266 + +I K E P P A LI R+ Sbjct: 246 SGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRL 305 Query: 267 LDPNPATRITFAEVIENEWF 286 L+ P+ R+T E + + +F Sbjct: 306 LEYTPSARLTAIEALCHPFF 325 >4PWN-A nrPDB Length = 274 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 129/282 (45%), Gaps = 24/282 (8%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G S+ GR E +G G+F V + E VA + K+ K++ + K Sbjct: 4 GMSNDGRFLKFDIE----IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSE-RQRFKE 58 Query: 79 EISTMKLIKHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 E +K ++HPN++R ++ S K I V E +T G L + +K R + Sbjct: 59 EAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSW 118 Query: 135 FQQLINAVDYCHSR--GVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTT 191 +Q++ + + H+R + HRDLK +N+ + G++K+ D GL+ L ++ + Sbjct: 119 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRA---SFAKSV 175 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF-EDSNLTSLYKKIFKAEFT 250 GTP ++APE+ K D+++ G+ + + P+ E N +Y+++ Sbjct: 176 IGTPEFMAPEMYEEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG--V 231 Query: 251 CPPWFS----ASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 P F K++I+ + N R + +++ + +F++ Sbjct: 232 KPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5AP3-A nrPDB Length = 313 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 122/272 (44%), Gaps = 19/272 (6%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK--H 88 Y + + +G G +KV N E AIK ++ E+ N+ + + EI+ + ++ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 87 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 148 +IR+++ + IY V+E +L + + E + Y++ ++ AV H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG- 207 G+ H DLKP N L+ +G LK+ DFG++ Q + + GT NY+ PE I + Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 208 ---------YDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLYKKIF--KAEFTCPPWF 255 K+D+WS G IL+ + G PF+ N S I E P Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + ++K L +P RI+ E++ + + + Sbjct: 266 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >3C1X-A nrPDB Length = 373 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 58/259 (22%), Positives = 112/259 (43%), Gaps = 12/259 (4%) Query: 32 ELGRTLGEGTFAKVKFARNVEN---GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +G G F V ++N + A+K ++ ++ ++Q E MK H Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSH 149 Query: 89 PNVIRMFEVM-ASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCH 146 PNV+ + + S+ VL ++ G+L + I + + + Q+ + + Sbjct: 150 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLA 209 Query: 147 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--TPNYVAPEVIN 204 S+ HRDL N +LD +KV+DFGL+ D + + T ++A E + Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 205 NKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTC-PPWFSASAKKL 262 + + K+D+WS GV+L+ LM G P+ D N + + + P + ++ Sbjct: 270 TQKFTT-KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 328 Query: 263 IKRILDPNPATRITFAEVI 281 + + P R +F+E++ Sbjct: 329 MLKCWHPKAEMRPSFSELV 347 >3QUP-A nrPDB Length = 323 Score = 224 bits (572), Expect = 6e-59, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 114/278 (41%), Gaps = 26/278 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENG---DNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 ++ LGR LG+G F V+ A+ + VA+K++ + + + I + RE + MK Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD-IEEFLREAACMKEF 82 Query: 87 KHPNVIRMFEVMAS---KTKI---YFVLEFVTGGELFDKISSNG------RLKEDEARKY 134 HP+V ++ V K ++ +L F+ G+L + ++ L ++ Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 + ++Y SR HRDL N +L + + V+DFGLS + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCP 252 ++A E + + Y +D+W+ GV ++ +M G P+ +Y + P Sbjct: 203 VKWLALESLADNLY-TVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQP 261 Query: 253 PWFSASAKKLIKRILDPNPATRITF-------AEVIEN 283 P L+ + +P R +F ++ + Sbjct: 262 PECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >4LRM-A nrPDB Length = 334 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 126/300 (42%), Gaps = 21/300 (7%) Query: 6 TPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNV----AIKV 61 +PS P+++ + +++ + LG G F V + G+ V AIK Sbjct: 2 SPSGEAPNQALLR------ILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKE 55 Query: 62 IDKEKVLKNKMIAQIKREISTMKLIKHP---NVIRMFEVMASKTKIYFVLEFVTGGELFD 118 + + K +I E M + +P +V R+ + + T + + + + G L D Sbjct: 56 LR--EATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLD 112 Query: 119 KISSNG-RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSA 177 + + + + Q+ ++Y R + HRDL N+L+ +K++DFGL+ Sbjct: 113 YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK 172 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSN 236 L ++ ++A E I ++ Y ++D+WS GV ++ LM G P++ Sbjct: 173 LLGAEEKEYHAEGGKVPIKWMALESILHRIY-THQSDVWSYGVTVWELMTFGSKPYDGIP 231 Query: 237 LTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 + + + K E PP + ++ + + +R F E+I E+ K ++ Sbjct: 232 ASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELII-EFSKMARDPQRY 290 >4EQM-A nrPDB Length = 294 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 123/270 (45%), Gaps = 7/270 (2%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 GS G+ +Y++ LG G + V A + VAIK I K + + + +R Sbjct: 1 GSHMIGKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFER 60 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E+ + H N++ M +V Y V+E++ G L + I S+G L D A + Q+ Sbjct: 61 EVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQI 120 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++ + + H + HRD+KP+N+L+D+N LK+ DFG++ + H GT Y Sbjct: 121 LDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVL-GTVQYF 179 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKK-----IFKAEFTCPP 253 +PE + D D++S G++L+ ++ G PF S+ K + Sbjct: 180 SPEQAKGEATDEC-TDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRK 238 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIEN 283 S +I R + + A R + +++ Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTIQEMKD 268 >1ZXE-A nrPDB Length = 303 Score = 224 bits (570), Expect = 9e-59, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 129/290 (44%), Gaps = 38/290 (13%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 +E LG+G F +V ARN + AIK I + ++ I E+ + + Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEVMLLASLN 60 Query: 88 HPNVIRMFEVMASKTK-------------IYFVLEFVTGGELFDKISSNG-RLKEDEARK 133 H V+R + + ++ +E+ L+D I S + DE + Sbjct: 61 HQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR 120 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--------- 184 F+Q++ A+ Y HS+G+ HR+LKP N+ +D + +K+ DFGL+ + + Sbjct: 121 LFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNL 180 Query: 185 ---DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSL 240 L + GT YVA EV++ G+ K D++S G+I F ++ PF ++ Sbjct: 181 PGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNI 237 Query: 241 YKKIFKAEFTCPPWFSAS----AKKLIKRILDPNPATRITFAEVIENEWF 286 KK+ PP F + KK+I+ ++D +P R ++ + W Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >3FME-A nrPDB Length = 290 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 121/274 (44%), Gaps = 16/274 (5%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 84 + E LG G + V+ R+V +G +A+K I + + + +IS M+ Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MR 61 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK----ISSNGRLKEDEARKYFQQLIN 140 + P + + + + ++ +E + L I + ED K ++ Sbjct: 62 TVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 141 AVDYCHSR-GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 A+++ HS+ V HRD+KP N+L++A G +K+ DFG+S + +D G Y+A Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVDDVAKDIDAGCKPYMA 177 Query: 200 PEVIN---NKGYDGAKADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKAEFTCP-P 253 PE IN N+ K+D+WS G+ + L P+ + L + + + P Sbjct: 178 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 237 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIENEWFK 287 FSA + L N R T+ E++++ +F Sbjct: 238 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >5AIR-A nrPDB Length = 430 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 127/316 (40%), Gaps = 49/316 (15%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 + R + Y + +G G+F V A+ ++G+ VAIK + ++K KN Sbjct: 51 VATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN----- 105 Query: 76 IKREISTMKLIKHPNVIRMFEVM----ASKTKIYF--VLEFVT---GGELFDKISSNGRL 126 RE+ M+ + H N++R+ K ++Y VL++V + L Sbjct: 106 --RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTL 163 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL-KVSDFGLSALPQQVRED 185 + Y QL ++ Y HS G+ HRD+KP+NLLLD + A+ K+ DFG + + + Sbjct: 164 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN 223 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF 245 + + Y APE+I + D+WS G +L L+ G F + +I Sbjct: 224 ---VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 280 Query: 246 KA-----------------EFTCP------------PWFSASAKKLIKRILDPNPATRIT 276 K EF P P A L R+L+ P R+T Sbjct: 281 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 340 Query: 277 FAEVIENEWFKKGYKA 292 E + +F + Sbjct: 341 PLEACAHSFFDELRDP 356 >1TKI-A nrPDB Length = 321 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 69/267 (25%), Positives = 126/267 (47%), Gaps = 15/267 (5%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 KY + LG G F V + K + +K +K+EIS + + +H Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK----VKGTDQVLVKKEISILNIARH 60 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHS 147 N++ + E S ++ + EF++G ++F++I+++ L E E Y Q+ A+ + HS Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 148 RGVYHRDLKPENLLLDA--NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + H D++PEN++ + +K+ +FG + + LL T P Y APEV + Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA---PEYYAPEVHQH 177 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSASAKK 261 D+WS G +++VL++G PF + + I AE+T S A Sbjct: 178 DVV-STATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMD 236 Query: 262 LIKRILDPNPATRITFAEVIENEWFKK 288 + R+L +R+T +E +++ W K+ Sbjct: 237 FVDRLLVKERKSRMTASEALQHPWLKQ 263 >4PL5-B nrPDB Length = 435 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 79/326 (24%), Positives = 134/326 (41%), Gaps = 29/326 (8%) Query: 36 TLGEGTFAK-VKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 LG G V + + +VA+K I E Q+ RE +HPNVIR Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFADREVQLLRESD-----EHPNVIRY 86 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED-EARKYFQQLINAVDYCHSRGVYHR 153 F + Y +E L + + E Q + + + HS + HR Sbjct: 87 FCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHR 145 Query: 154 DLKPENLLL---DANGALK--VSDFGLSALPQQVREDGLLHTTC-GTPNYVAPEVINNKG 207 DLKP N+LL +A+G +K +SDFGL R + GT ++APE+++ Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 208 YD--GAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPP---WFSASAKK 261 D D++S G + + +++ GY PF S + C A++ Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARE 265 Query: 262 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVE 321 LI++++ +P R + V+++ +F K +F D D I ++ + +V Sbjct: 266 LIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQ-----DVSDRIEKEALDGP--IVR 318 Query: 322 RREEGLKTPVTMNAFELISTSQGLNL 347 + E G + V M+ E I+ +L Sbjct: 319 QLERGGRAVVKMDWRENITVPLQTDL 344 >2OZO-A nrPDB Length = 613 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 111/292 (38%), Gaps = 20/292 (6%) Query: 2 ASRTTPSRSTPSRST--PSGSSSGGRTRVGKYELGR--------TLGEGTFAKVKFA--R 49 + R P ++ S S + K L R LG G F V+ R Sbjct: 299 ITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR 358 Query: 50 NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLE 109 + +VAIKV+ + + ++ RE M + +P ++R+ V ++ + V+E Sbjct: 359 MRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVME 415 Query: 110 FVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL 168 GG L + + + Q+ + Y + HR+L N+LL Sbjct: 416 MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYA 475 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAKADLWSCGVILFV-LM 226 K+SDFGLS + P + APE IN + + +++D+WS GV ++ L Sbjct: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SSRSDVWSYGVTMWEALS 534 Query: 227 AGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPNPATRITF 277 G P++ + I + + CPP L+ R F Sbjct: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 >6HV0-A nrPDB Length = 416 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 83/340 (24%), Positives = 139/340 (40%), Gaps = 31/340 (9%) Query: 24 GRTRVGKYELG--RTLGEGTFAK-VKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 VGK LG G V + + +VA+K I E Q+ RE Sbjct: 1 SVVIVGKISFCPKDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRES 58 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED-EARKYFQQLI 139 +HPNVIR F + Y +E L + + E QQ Sbjct: 59 D-----EHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTT 112 Query: 140 NAVDYCHSRGVYHRDLKPENLLL---DANGALK--VSDFGLSALPQQVREDGLLHTTC-G 193 + + + HS + HRDLKP N+L+ +A+G +K +SDFGL R + G Sbjct: 113 SGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPG 172 Query: 194 TPNYVAPEVINN--KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFT 250 T ++APE+++ K D++S G + + +++ G PF S + Sbjct: 173 TEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLD 232 Query: 251 C--PP-WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDA 307 C P A++LI++++ +P R + V+++ +F K +F D D Sbjct: 233 CLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQ-----DVSDR 287 Query: 308 IFDDSGESKNLVVERREEGLKTPVTMNAFELISTSQGLNL 347 I +S + +V++ E G + V M+ E I+ +L Sbjct: 288 IEKESLDGP--IVKQLERGGRAVVKMDWRENITVPLQTDL 325 >1U59-A nrPDB Length = 287 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 100/248 (40%), Gaps = 10/248 (4%) Query: 36 TLGEGTFAKVKFA--RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 LG G F V+ R + +VAIKV+ + + ++ RE M + +P ++R Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVR 74 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 + V ++ + V+E GG L + + + Q+ + Y + H Sbjct: 75 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGA 211 RDL N+LL K+SDFGLS + P + APE IN + + + Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SS 192 Query: 212 KADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDP 269 ++D+WS GV ++ L G P++ + I + + CPP L+ Sbjct: 193 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 252 Query: 270 NPATRITF 277 R F Sbjct: 253 KWEDRPDF 260 >3I81-A nrPDB Length = 315 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 126/300 (42%), Gaps = 22/300 (7%) Query: 29 GKYELGRTLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 K + R LG+G+F V E VAIK +++ ++ ++ + E S M Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERI--EFLNEASVM 75 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-------NGRLKEDEARKYFQ 136 K +V+R+ V++ ++E +T G+L + S N L K Q Sbjct: 76 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQ 135 Query: 137 ---QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 ++ + + Y ++ HRDL N ++ + +K+ DFG++ + Sbjct: 136 MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL 195 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTC 251 +++PE + + + +D+WS GV+L+ + P++ + + + + + Sbjct: 196 PVRWMSPESLKDGVFTTY-SDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK 254 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIEN--EWFKKGYKAPKFENADVSLDDVDAIF 309 P +L++ NP R +F E+I + E + G++ F ++ + + + + Sbjct: 255 PDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKMENNPVL 314 >3M42-A nrPDB Length = 299 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 78/309 (25%), Positives = 137/309 (44%), Gaps = 54/309 (17%) Query: 28 VGKYEL-GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KL 85 + Y++ + LG G KV N + A+K++ + + +RE+ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 86 IKHPNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLI 139 + P+++R+ +V + + + V+E + GGELF +I G E EA + + + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 140 NAVDYCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 A+ Y HS + HRD+KPENLL + N LK++DFG + Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----------------- 170 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFT 250 + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF Sbjct: 171 -------TGEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 222 Query: 251 CPPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK--FENADVSLDDVD 306 P W S K LI+ +L P R+T E + + W + K P+ + V +D + Sbjct: 223 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 282 Query: 307 AIFDDSGES 315 D E Sbjct: 283 RWEDVKEEM 291 >3PLS-A nrPDB Length = 298 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 115/256 (44%), Gaps = 12/256 (4%) Query: 35 RTLGEGTFAKVKFARNVENGDN---VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 R +G+G F V ++ N AIK + ++ + + + RE M+ + HPNV Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS--RITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 92 IRMFEVMASKTKI-YFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSRG 149 + + +M + + +L ++ G+L I S R + + Q+ ++Y + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSA--LPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 HRDL N +LD + +KV+DFGL+ L ++ + A E + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 208 YDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKR 265 + K+D+WS GV+L+ L+ G P+ + L + + P + S +++++ Sbjct: 205 FTT-KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 263 Query: 266 ILDPNPATRITFAEVI 281 + +PA R TF ++ Sbjct: 264 CWEADPAVRPTFRVLV 279 >5KKR-C nrPDB Length = 395 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 118/314 (37%), Gaps = 52/314 (16%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 63 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 120 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 121 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 180 Query: 144 YC-HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + HRD+KP N+L+++ G +K+ DFG+S D + ++ GT +Y++PE Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPER 236 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLT------------------------ 238 + + ++D+WS G+ L + G P + Sbjct: 237 LQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 295 Query: 239 ------------------SLYKKIFKAEFTCPPW--FSASAKKLIKRILDPNPATRITFA 278 L I P FS + + + L NPA R Sbjct: 296 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLK 355 Query: 279 EVIENEWFKKGYKA 292 +++ + + K+ Sbjct: 356 QLMVHAFIKRSDAE 369 >5HVK-A nrPDB Length = 315 Score = 221 bits (563), Expect = 7e-58, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 125/293 (42%), Gaps = 30/293 (10%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 G LG+G F + + E G+ + +K + + + +E+ M+ ++HPNV++ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHPNVLK 75 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 V+ ++ F+ E++ GG L I S + + + + + + + + Y HS + H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVRED------------GLLHTTCGTPNYVAP 200 R+L N L+ N + V+DFGL+ L + +T G P ++AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 201 EVINNKGYDGAKADLWSCGVILFVLMAG---YLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 E+IN + YD K D++S G++L ++ + + + CPP Sbjct: 196 EMINGRSYD-EKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPP 254 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA--------PKFENADVSL 302 S + R D +P R +F + +E+ W + P+ E D Sbjct: 255 SFFPITVRCCDLDPEKRPSFVK-LEH-WLETLRMHLAGHLPLGPQLEQLDRGF 305 >5WNO-A nrPDB Length = 330 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 131/301 (43%), Gaps = 18/301 (5%) Query: 32 ELGRTLGEGTFAKVKFA-----RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 +L + LG G F V R VAIKV ++ ++M+ E + M + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLE----EATNMFRL 80 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYC 145 +H N++++ + V + G L + + + L E Y Q+ + + Y Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 146 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 + V HRDL N+L+ ++++DFGLS + + + + + ++A E+ + Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 206 KGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLI 263 Y +D+W+ GV + ++ G P++ + S++ + + PP S + + Sbjct: 201 HCY-THASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 264 KRILDPNPATRITFAEVIENEWFKKGYKAPK--FENAD-VSLDDVDAIFDDSGESKNLVV 320 R +P +R F E++ E FK+ K P+ EN++ +S D+ A E + Sbjct: 260 LRCWMADPKSRPGF-EIL-YERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMF 317 Query: 321 E 321 + Sbjct: 318 D 318 >5Y86-A nrPDB Length = 588 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 77/333 (23%), Positives = 129/333 (38%), Gaps = 80/333 (24%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-- 87 +YE+ + +G+G+F +V + + VA+K++ EK + Q EI ++ +K Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK----RFHRQAAEEIRILEHLKKQ 263 Query: 88 ----HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINA 141 NVI M E + + E ++ +L++ I N RK+ Q ++ + Sbjct: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +D H + H DLKPEN+LL +G KV DFG S E L+T + Y A Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-----EYQKLYTYIQSRFYRA 377 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN---------------LTSLYKKI 244 PE+I Y D+WS G IL L+ G F + L ++ Sbjct: 378 PEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 Query: 245 FKAEF-----TCPPWFSAS---------------------------------------AK 260 +A++ P + S + Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 + +KR L +P+ R+T A+ + + W K P Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 >3PG1-A nrPDB Length = 362 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 117/341 (34%), Gaps = 51/341 (14%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVI-------DKEKVLKNKMI-AQIKREIST 82 Y + R + G++ V + E G VAIK + +L + + ++ REI Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 83 MKLIKHPNVIRMFEVMAS-----KTKIYFVLEFVTGGELFDKIS-SNGRLKEDEARKYFQ 136 + HPN++ + ++ K+Y V E + +L I + + + Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQYFMY 141 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 ++ + H GV HRDL P N+LL N + + DF L+ T Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTH---RW 198 Query: 197 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK---------- 246 Y APE++ D+WS G ++ + F S + KI + Sbjct: 199 YRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDV 258 Query: 247 AEFTCP----------------------PWFSASAKKLIKRILDPNPATRITFAEVIENE 284 F+ P P A LI ++L+ NP RI+ + + + Sbjct: 259 VMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHP 318 Query: 285 WFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREE 325 +F+ + D D + + E Sbjct: 319 YFESLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVER 359 >3EQC-A nrPDB Length = 360 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 118/314 (37%), Gaps = 52/314 (16%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V + +G +A K+I E +K + QI RE+ + Sbjct: 28 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 85 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + GR+ E K +I + Sbjct: 86 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 144 YC-HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + HRD+KP N+L+++ G +K+ DFG+S D + ++ GT +Y++PE Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMSPER 201 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLT------------------------ 238 + + ++D+WS G+ L + G P + Sbjct: 202 LQG-THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTP 260 Query: 239 ------------------SLYKKIFKAEFTCPPW--FSASAKKLIKRILDPNPATRITFA 278 L I P FS + + + L NPA R Sbjct: 261 GRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 320 Query: 279 EVIENEWFKKGYKA 292 +++ + + K+ Sbjct: 321 QLMVHAFIKRSDAE 334 >3ZBF-A nrPDB Length = 322 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 102/272 (37%), Gaps = 23/272 (8%) Query: 29 GKYELGRTLGEGTFAKVKFARNVE-----NGD-NVAIKVIDKEKVLKNKMIAQIKREIST 82 K L LG G F +V V+ +G+ VA+K + K + K+ + +E Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHL 90 Query: 83 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISS-------NGRLKEDEARKYF 135 M HPN+++ V Y +LE + GG+L + L + Sbjct: 91 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 150 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLL-----DANGALKVSDFGLSALPQQVREDGLLHT 190 + Y HRDL N L+ + +K+ DFGL+ + Sbjct: 151 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 210 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEF 249 ++APE + + G ++D+WS G++++ ++ G+ P+ + + + Sbjct: 211 GLLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGR 269 Query: 250 TCPP-WFSASAKKLIKRILDPNPATRITFAEV 280 PP L+ + P R TF + Sbjct: 270 LEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 301 >4FL3-A nrPDB Length = 635 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 6/250 (2%) Query: 35 RTLGEGTFAKVKFARN-VENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 + LG G F VK ++ I K + + ++ E + M+ + +P ++R Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 M + +++ + V+E G L + N +K+ + Q+ + Y HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAK 212 DL N+LL K+SDFGLS + T P + APE IN + +K Sbjct: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 552 Query: 213 ADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPN 270 +D+WS GV+++ G P+ + + + K E CP L+ + Sbjct: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 Query: 271 PATRITFAEV 280 R FA V Sbjct: 613 VENRPGFAAV 622 >4HVI-A nrPDB Length = 314 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 114/272 (41%), Gaps = 36/272 (13%) Query: 37 LGEGTFAKVKFARNVE----NGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG+G F V+ R G VA+K + + +REI +K + ++ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQL---QHSGPDQQRDFQREIQILKALHSDFIV 74 Query: 93 RMFEVMASKTK--IYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHSRG 149 + V + + V+E++ G L D + + RL Y Q+ ++Y SR Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGY 208 HRDL N+L+++ +K++DFGL+ L ++ ++ +P + APE +++ + Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 209 DGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKA-----------------E 248 ++D+WS GV+L+ L + D S + + Sbjct: 195 -SRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR 249 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 PP A +L+K P+P R +F+ + Sbjct: 250 LPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5O0Y-A nrPDB Length = 579 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 115/269 (42%), Gaps = 24/269 (8%) Query: 42 FAKVKFARNVENGDNVAIKV--IDK--EKVLKNKMIAQIKREISTMKLIKHPNVIRMFEV 97 F++V A ++ VA+K+ ++K K RE K + HP ++++++ Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 98 MA-SKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS--RGVYHRD 154 + VLE+ G +L + + + E EAR Q++NA+ Y + + H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 155 LKPENLLL---DANGALKVSDFGLSALPQQVREDG-----LLHTTCGTPNYVAPEVI--- 203 LKP N+LL A G +K++DFGLS + + L GT Y+ PE Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLPF------EDSNLTSLYKKIFKAEFTCPPWFSA 257 K D+WS GVI + + G PF +D + K + +F P + Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWF 286 AK I+R L RI ++ + + Sbjct: 537 EAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >6FER-A nrPDB Length = 309 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 100/285 (35%), Gaps = 39/285 (13%) Query: 32 ELGRTLGEGTFAKVKFAR--------------NVENGDNV--AIKVIDKEKVLKNKMIAQ 75 LGEG F +V +V V A+K++ + Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRAD--ANKNARND 69 Query: 76 IKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR---------- 125 +EI M +K PN+I + V + + + E++ G+L +S + Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRT 129 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 + + Q+ + + Y S HRDL N L+ N +K++DFG+S Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFV--LMAGYLPFEDSNLTSLYK- 242 + +++ E I + A +D+W+ GV L+ P+ + + + Sbjct: 190 RIQGRAVLPIRWMSWESILLGKFTTA-SDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 248 Query: 243 -------KIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 + + P S KL+ + R +F E+ Sbjct: 249 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >3E3P-A nrPDB Length = 360 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 75/357 (21%), Positives = 133/357 (37%), Gaps = 61/357 (17%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 S S + + + R + ++++ R G+GTF V+ + G +VAIK + ++ Sbjct: 2 PGSMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPR 61 Query: 68 LKNKMIAQIKREISTM---KLIKHPNVIRMFEVM-----ASKTKIYF--VLEFVT---GG 114 +N RE+ M ++ HPN++++ + IY V+E+V Sbjct: 62 FRN-------RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHR 114 Query: 115 ELFDKISSNGRLKEDEARKYFQQLINAVDYCH--SRGVYHRDLKPENLLLDA-NGALKVS 171 + + + QLI ++ H S V HRD+KP N+L++ +G LK+ Sbjct: 115 CCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLC 174 Query: 172 DFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 DFG + + + Y APE+I + D+WS G I +M G Sbjct: 175 DFGSAKKLSPSEPNVAY---ICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPI 231 Query: 232 FEDSNLTSLYKKIFKAEFTCP-----------------------PWFS----------AS 258 F N +I + CP PW + Sbjct: 232 FRGDNSAGQLHEIVRV-LGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKE 290 Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKKGYKA-PKFENADVSLDDVDAIFDDSGE 314 A L+ +L P R+ E + + +F + + K N +D+ + E Sbjct: 291 AYDLLSALLQYLPEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIE 347 >2EHB-D nrPDB Length = 143 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 65/127 (51%), Positives = 94/127 (74%) Query: 330 PVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDVK 389 P+ MNAFE+I+ SQGLNL +LF+++ VKR+TRF S+ +EI+ IEA A MGF Sbjct: 4 PLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGFKSH 63 Query: 390 TNNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRKSGGDTLEFHKFYKNLTTGLKD 449 T N+K +L G S + GQLAV E+++VAPSL+MV++RK+ G+TLE+HKFYK L + L++ Sbjct: 64 TRNFKTRLEGLSSIKAGQLAVVIEIYEVAPSLFMVDVRKAAGETLEYHKFYKKLCSKLEN 123 Query: 450 IVWKTID 456 I+W+ + Sbjct: 124 IIWRATE 130 >5C26-A nrPDB Length = 299 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 6/250 (2%) Query: 35 RTLGEGTFAKVKFARN-VENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 + LG G F VK ++ I K + + ++ E + M+ + +P ++R Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 M + +++ + V+E G L + N +K+ + Q+ + Y HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDGAK 212 DL N+LL K+SDFGLS + T P + APE IN + +K Sbjct: 152 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 210 Query: 213 ADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPN 270 +D+WS GV+++ G P+ + + + K E CP L+ + Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 270 Query: 271 PATRITFAEV 280 R FA V Sbjct: 271 VENRPGFAAV 280 >3N9X-A nrPDB Length = 432 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 79/367 (21%), Positives = 130/367 (35%), Gaps = 89/367 (24%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y + +G G++ V A + NVAIK +++ +I REI+ + +K Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR-MFEDLIDCKRILREITILNRLKS 84 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 +IR+++++ ++Y VLE +L + L E+ + L+ + Sbjct: 85 DYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG----------------- 186 + H G+ HRDLKP N LL+ + ++KV DFGL+ ++ Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 187 ---LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-----------AGYLPF 232 L + T Y APE+I + D+WS G I L+ + F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 233 EDS-----------------------------------------NLTSLYKKIFKAEFTC 251 S N + K I Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRK 323 Query: 252 P-------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDD 304 P P S L++ +L NP RIT + +++ + K K K EN S Sbjct: 324 PINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKK-KLENF--STKK 380 Query: 305 VDAIFDD 311 + FDD Sbjct: 381 IILPFDD 387 >6B2Q-A nrPDB Length = 317 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 118/269 (43%), Gaps = 12/269 (4%) Query: 16 TPSGSSSG----GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK 71 P GS G T G+Y L R + G +V A + G VA+KV+ E + Sbjct: 15 VPRGSLHMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE 74 Query: 72 MIAQIKREISTMKLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRL 126 I + + E T ++ HP + + + S+ Y V+E V G L + GRL Sbjct: 75 FIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRL 134 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 A +Q A+ H+ G+ HRD+KP N+L+ G +K++DFG++ Sbjct: 135 SLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAV-DAAPVT 193 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLYKKIF 245 GT Y+APE +D++S GV+ + ++G PF LT K I Sbjct: 194 QTGMVMGTAQYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 252 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATR 274 + PP + ++LI+ L NPA R Sbjct: 253 EPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >5U6C-A nrPDB Length = 315 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 102/262 (38%), Gaps = 18/262 (6%) Query: 33 LGRTLGEGTFAKVKFA---RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 LG+ LGEG F V + VA+K + + + + I + E + MK HP Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQ-REIEEFLSEAACMKDFSHP 98 Query: 90 NVIRMFEVMASK-----TKIYFVLEFVTGGELFDKI------SSNGRLKEDEARKYFQQL 138 NV+R+ V K +L F+ G+L + + + K+ + Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYV 198 ++Y +R HRDL N +L + + V+DFGLS ++ Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWI 218 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFS 256 A E + ++ Y K+D+W+ GV ++ + G P+ +Y + P Sbjct: 219 AIESLADRVYTS-KSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 257 ASAKKLIKRILDPNPATRITFA 278 +++ +P R TF+ Sbjct: 278 DELYEIMYSCWRTDPLDRPTFS 299 >4OW8-A nrPDB Length = 283 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 78/285 (27%), Positives = 125/285 (43%), Gaps = 14/285 (4%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S G T G+Y L R + G +V A + G VA+KV+ E + I + + E Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 61 Query: 80 ISTMKLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 T ++ HP + + + S+ Y V+E V G L + GRL A Sbjct: 62 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 121 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 +Q A+ H+ G+ HRD+KP N+L+ G +K++DFG++ GT Sbjct: 122 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAV-DAAPVTQTGMVMGT 180 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLYKKIFKAEFTCPP 253 Y+APE +D++S GV+ + ++G PF LT K I + PP Sbjct: 181 AQYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPP 239 Query: 254 WFSASAKKLIKRILDPNPATRIT----FAEVIENEWFKKGYKAPK 294 + ++LI+ L NPA R FA+ + + G + P+ Sbjct: 240 DLPPNVRELIEITLVKNPAMRYRSGGPFADAV--AAVRAGRRPPR 282 >4X3F-A nrPDB Length = 337 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 74/261 (28%), Positives = 116/261 (44%), Gaps = 8/261 (3%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S G T G+Y L R + G +V A + G VA+KV+ E + I + + E Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 62 Query: 80 ISTMKLIKHPNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKY 134 T ++ HP + + + S+ Y V+E V G L + GRL A Sbjct: 63 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 122 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 +Q A+ H+ G+ HRD+KP N+L+ G +K++DFG++ GT Sbjct: 123 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAV-DAAPVTQTGMVMGT 181 Query: 195 PNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSN-LTSLYKKIFKAEFTCPP 253 Y+APE +D++S GV+ + ++G PF LT K I + PP Sbjct: 182 AQYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPP 240 Query: 254 WFSASAKKLIKRILDPNPATR 274 + ++LI+ L NPA R Sbjct: 241 DLPPNVRELIEITLVKNPAMR 261 >6DC0-A nrPDB Length = 292 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 83/269 (30%), Positives = 133/269 (49%), Gaps = 13/269 (4%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S+ G +R+ Y L L E V A + G + KV K ++K+ I+ Sbjct: 1 SAPGPSRIADYLLL-PLAE--REHVSRALCIHTGRELRCKVFPI-KHYQDKIRPYIQ--- 53 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 L H N+ + EV+ +TK Y E G++ + S RL+E+EA + F+Q+++ Sbjct: 54 ----LPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 108 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 AV +CH + DLK + ++ L ED L G P YV+P Sbjct: 109 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 168 Query: 201 EVINNKG-YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 E++N G Y G AD+WS GV+L+ L+ G PF DS+ ++L+ KI + +F P S A Sbjct: 169 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 228 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK 288 + LI+ +L P+ R+T E++ + WF+ Sbjct: 229 RCLIRSLLRREPSERLTAPEILLHPWFES 257 >1S9I-A nrPDB Length = 354 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 118/315 (37%), Gaps = 56/315 (17%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 G + +E LG G V ++ +G +A K+I E +K + QI RE+ + Sbjct: 11 GELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVL 68 Query: 84 KLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 P ++ + S +I +E + GG L + R+ E+ K ++ + Sbjct: 69 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 144 YC-HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 202 Y + HRD+KP N+L+++ G +K+ DFG+S D + ++ GT +Y+APE Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI----DSMANSFVGTRSYMAPER 184 Query: 203 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLT------------------------ 238 + + ++D+WS G+ L L G P + Sbjct: 185 LQG-THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPR 243 Query: 239 ----------------------SLYKKIFKAEFTCPPW--FSASAKKLIKRILDPNPATR 274 L I P F+ ++ + + L NPA R Sbjct: 244 PRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAER 303 Query: 275 ITFAEVIENEWFKKG 289 + + + K+ Sbjct: 304 ADLKMLTNHTFIKRS 318 >5CEK-A nrPDB Length = 263 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 83/269 (30%), Positives = 133/269 (49%), Gaps = 13/269 (4%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S+ G +R+ Y L L E V A + G + KV K ++K+ I+ Sbjct: 4 SAPGPSRIADYLLL-PLAE--REHVSRALCIHTGRELRCKVFPI-KHYQDKIRPYIQ--- 56 Query: 81 STMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 L H N+ + EV+ +TK Y E G++ + S RL+E+EA + F+Q+++ Sbjct: 57 ----LPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 111 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 200 AV +CH + DLK + ++ L ED L G P YV+P Sbjct: 112 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 171 Query: 201 EVINNKG-YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASA 259 E++N G Y G AD+WS GV+L+ L+ G PF DS+ ++L+ KI + +F P S A Sbjct: 172 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 231 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKK 288 + LI+ +L P+ R+T E++ + WF+ Sbjct: 232 RCLIRSLLRREPSERLTAPEILLHPWFES 260 >3AOX-A nrPDB Length = 344 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 99/284 (34%), Gaps = 20/284 (7%) Query: 16 TPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKN 70 S S L R LG G F +V + N + VA+K + +V Sbjct: 34 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVCSE 91 Query: 71 KMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----- 125 + E + H N++R V + +LE + GG+L + Sbjct: 92 QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQP 151 Query: 126 --LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG---ALKVSDFGLSALPQ 180 L + + + Y HRD+ N LL G K+ DFG++ Sbjct: 152 SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY 211 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTS 239 + ++ PE G +K D WS GV+L+ + + GY+P+ + Sbjct: 212 RASYYRKGGCAMLPVKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQE 270 Query: 240 LYKKIFKAEFTCPPW-FSASAKKLIKRILDPNPATRITFAEVIE 282 + + + PP +++ + P R FA ++E Sbjct: 271 VLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >4Y83-A nrPDB Length = 332 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 64/268 (23%), Positives = 122/268 (45%), Gaps = 23/268 (8%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 + G F KV A++++ +A K+I ++ + + +H N+ ++ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYG 132 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + ++ +E GG + +K+ S G ++E E + ++ +D+ HS+ V H D+K Sbjct: 133 AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 192 Query: 157 PENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 P N++ + A+ + DFGLS Q + GT Y++PEVI +G+ KAD++ Sbjct: 193 PSNIVFMSTKAV-LVDFGLS--VQMTEDVYFPKDLRGTEIYMSPEVILCRGH-STKADIY 248 Query: 217 SCGVILFVLMAGYLPFEDSNLTSLY-KKIFKAEFTCPP------WFSASAKKLIKRILDP 269 S G L + G P+ S Y ++ PP S ++LI+ L+ Sbjct: 249 SLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLER 308 Query: 270 NPATRITFAEVIENEWFKKGYKAPKFEN 297 NP R A+++++E P+ + Sbjct: 309 NPNHRPRAADLLKHE----ALNPPREDQ 332 >4NEU-A nrPDB Length = 333 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 71/325 (21%), Positives = 135/325 (41%), Gaps = 25/325 (7%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 P S + + + + L G F KV + G + +K + K + + Sbjct: 12 PDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNC-IEHNEAL 69 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 136 E M ++H V+++ V+ + K V+E++ G L + + + Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 129 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL----------PQQVRE-D 185 ++I + Y H +GV H+DLKPEN+L+D + +K++D GL++ ++RE D Sbjct: 130 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 189 Query: 186 GLLHTTCGTPNYVAPEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLYKK 243 G GT Y+APE +N+ K+D++S V+L+ + A P+E+ L Sbjct: 190 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC 249 Query: 244 IFKAEFT----CPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENAD 299 I + L+K + NP R TF ++ ++ + Sbjct: 250 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTF------PGIEEKFRPFYLSQLE 303 Query: 300 VSLDDVDAIFDDSGESKNLVVERRE 324 S+++ ++N VV+R + Sbjct: 304 ESVEEDVKSLKKEYSNENAVVKRMQ 328 >4IDT-A nrPDB Length = 356 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 118/283 (41%), Gaps = 30/283 (10%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 LG G+F +V + + G A+K + E E+ + P ++ ++ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 133 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + + +E + GG L + G L ED A Y Q + ++Y HSR + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 157 PENLLLDANG-ALKVSDFGLSALPQQVREDGLLHT---TCGTPNYVAPEVINNKGYDGAK 212 +N+LL ++G + DFG + Q L T GT ++APEV+ + D AK Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD-AK 252 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT---CPPWFSASAKKLIKRILDP 269 D+WS ++ ++ G P+ L KI PP + + I+ L Sbjct: 253 VDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRK 312 Query: 270 NPATRITFAEV-------------IENEWFKKGYKAPKFENAD 299 P R++ AE+ +++ W + YK P+ + Sbjct: 313 EPIHRVSAAELGGKVNRALQQVGGLKSPW-RGEYKEPRHPPPN 354 >3NIE-A nrPDB Length = 429 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 70/351 (19%), Positives = 118/351 (33%), Gaps = 89/351 (25%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 YE+ +G G++ V A + NVAIK +++ +I REI+ + +K Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR-MFEDLIDCKRILREITILNRLKS 86 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 143 +IR+ +++ + ++Y VLE +L + L E + L+ Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 144 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE------------------- 184 + H G+ HRDLKP N LL+ + ++K+ DFGL+ ++ Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 185 ----DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-----------AGY 229 L + T Y APE+I + D+WS G I L+ + Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 230 LPFEDS-----------------NLTSLYKKIFKAEFTCPPW------------------ 254 F S + IF T P Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 255 -------------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 S L++ +L N RIT + + + + K K Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >5UIU-A nrPDB Length = 323 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 103/268 (38%), Gaps = 23/268 (8%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDK-EKVLKNKMIAQIKREISTMKLIKHPNVI 92 G +GEG F V N VA+K + + ++ Q +EI M +H N++ Sbjct: 52 GNKMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 109 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISS---NGRLKEDEARKYFQQLINAVDYCHSRG 149 + + + V ++ G L D++S L K Q N +++ H Sbjct: 110 ELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENH 169 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD 209 HRD+K N+LLD K+SDFGL+ ++ + + GT Y+APE + + Sbjct: 170 HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--I 227 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLY---------------KKIFKAEFTCPPW 254 K+D++S GV+L ++ G ++ L I K Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 287 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIE 282 + + + L R +V + Sbjct: 288 SVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >5X8I-B nrPDB Length = 346 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 82/338 (24%), Positives = 126/338 (37%), Gaps = 83/338 (24%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 G +YE+ TLGEG F KV + G +VA+K++ ++ + E Sbjct: 5 CQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNV----DRYCEAARSE 60 Query: 80 ISTMKLIK--HPN----VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK--EDEA 131 I ++ + PN ++M E I V E + G +D I NG L D Sbjct: 61 IQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHI 119 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-------------------NGALKVSD 172 RK Q+ +V++ HS + H DLKPEN+L N +KV D Sbjct: 120 RKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVD 179 Query: 173 FGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 FG + +D T T +Y APEVI G+ D+WS G IL G+ F Sbjct: 180 FGSATY-----DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVF 233 Query: 233 EDSNLTSLYKKIFKAEFTCP---------------------------PWFSASAK----- 260 + + + P + S + K Sbjct: 234 PTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEF 293 Query: 261 ------------KLIKRILDPNPATRITFAEVIENEWF 286 LI+++L+ +PA RIT E +++ +F Sbjct: 294 MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4C59-A nrPDB Length = 340 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 82/280 (29%), Positives = 123/280 (43%), Gaps = 34/280 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-H 88 + + R L EG FA V A++V +G A+K + + KN+ I +E+ MK + H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA---IIQEVCFMKKLSGH 84 Query: 89 PNVIRM-----FEVMASKT---KIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQL 138 PN+++ S T + + E G E K+ S G L D K F Q Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQT 144 Query: 139 INAVDYCHSRG--VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG--- 193 AV + H + + HRDLK ENLLL G +K+ DFG + + Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 194 -------TPNYVAPEVINNKGYD--GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI 244 TP Y PE+I+ G K D+W+ G IL++L PFED +I Sbjct: 205 EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RI 260 Query: 245 FKAEFTCPPWFSA--SAKKLIKRILDPNPATRITFAEVIE 282 +++ PP + LI+ +L NP R++ AEV+ Sbjct: 261 VNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVH 300 >4M7I-A nrPDB Length = 299 Score = 210 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 76/292 (26%), Positives = 123/292 (42%), Gaps = 37/292 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +E + LG G F V A+N + N AIK I + ++ RE+ + ++HP Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAKLEHP 63 Query: 90 NVIRMFEVMASKT------------KIYFVLEFVTGGELFDKISSNGRLKEDEA---RKY 134 ++R F K +Y ++ L D ++ ++E E Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 135 FQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL------ 188 F Q+ AV++ HS+G+ HRDLKP N+ + +KV DFGL Q E+ + Sbjct: 124 FLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 189 ----HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI 244 GT Y++PE I+ Y K D++S G+ILF L+ PF S + + Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELLY---PF--STQMERVRTL 237 Query: 245 FKAE-FTCPPWFS---ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 292 PP F+ +++ +L P+P R +IEN F+ Sbjct: 238 TDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFP 289 >5B2L-A nrPDB Length = 324 Score = 210 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 132/305 (43%), Gaps = 28/305 (9%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 + + E +G GT +V R + G +A+K + + + +I ++ Sbjct: 9 GQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN--KRILMDL 66 Query: 81 ST-MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQ 137 +K P +++ F + T ++ +E + G +K+ G + E K Sbjct: 67 DVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVA 124 Query: 138 LINAVDYC-HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 196 ++ A+ Y GV HRD+KP N+LLD G +K+ DFG+S ++ + + G Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISG---RLVDSKAKTRSAGCAA 181 Query: 197 YVAPEVIN----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLT-SLYKKIFKAEFTC 251 Y+APE I+ K +AD+WS G+ L L G P+++ + K+ + E Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 241 Query: 252 PP---WFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAI 308 P FS + +K L + R + +++E+ + K ++E +V DV + Sbjct: 242 LPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK------RYETLEV---DVASW 292 Query: 309 FDDSG 313 F D Sbjct: 293 FKDVM 297 >5ZTN-A nrPDB Length = 429 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 126/333 (37%), Gaps = 80/333 (24%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 +YE+ + +G+G+F +V A + + +VA+K++ EK + Q EI ++ ++ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK----RFHRQAAEEIRILEHLRKQ 153 Query: 90 ------NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINA 141 NVI M E + I E ++ L++ I N RK+ ++ Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVA 199 +D H + H DLKPEN+LL G +KV DFG S Q ++T + Y A Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ-----RVYTYIQSRFYRA 267 Query: 200 PEVINNKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKI----------- 244 PEVI Y G D+WS G IL L+ GY E L + + + Sbjct: 268 PEVILGARY-GMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDAS 326 Query: 245 ---------------------------------FKAEFTCPPWF-----------SASAK 260 + + PP Sbjct: 327 KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 386 Query: 261 KLIKRILDPNPATRITFAEVIENEWFKKGYKAP 293 +K+ L+ +PA R+T + + + W ++ P Sbjct: 387 DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP 419 >4TPT-A nrPDB Length = 303 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 64/276 (23%), Positives = 121/276 (43%), Gaps = 32/276 (11%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 G LG+G F + + G + +K + + + E+ M+ + HPNV++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIR---CDEETQKTFLTEVKVMRSLDHPNVLK 61 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 V+ K+ + E++ GG L D + S + ++ + + + + Y HS + HR Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 154 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLL------------------HTTCGTP 195 DL N L+ + + V+DFGLS L + R+ + +T G P Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTS------LYKKIFKAEF 249 ++APE++N K YD D++S G++L ++ G + + D + L K+F +F Sbjct: 182 YWMAPEMLNGKSYD-ETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKLFWEKF 238 Query: 250 TCPPWFSASAKKLIKRILDPNPATRITFAEVIENEW 285 P + L P +R F++ +E+ + Sbjct: 239 -VPTDCPPAFFPLAAICCRLEPESRPAFSK-LEDSF 272 >3ALO-A nrPDB Length = 327 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 123/284 (43%), Gaps = 26/284 (9%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 + +G G + V + +G +A+K I + K Q+ ++ Sbjct: 14 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIR--STVDEKEQKQLLMDL 71 Query: 81 ST-MKLIKHPNVIRMFEVMASKTKIYFVLEFVT--GGELFDKISS--NGRLKEDEARKYF 135 M+ P +++ + + + + +E ++ + + + S + + E+ K Sbjct: 72 DVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKIT 131 Query: 136 QQLINAVDYCHSR-GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT 194 + A+++ + HRD+KP N+LLD +G +K+ DFG+S Q+ + G Sbjct: 132 LATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG---QLVDSIAKTRDAGC 188 Query: 195 PNYVAPEVIN----NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT 250 Y+APE I+ +GYD ++D+WS G+ L+ L G P+ N S++ ++ + Sbjct: 189 RPYMAPERIDPSASRQGYD-VRSDVWSLGITLYELATGRFPYPKWN--SVFDQLTQVVKG 245 Query: 251 CPP--------WFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 PP FS S + L + + R + E++++ + Sbjct: 246 DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3ZZW-A nrPDB Length = 289 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 101/272 (37%), Gaps = 26/272 (9%) Query: 32 ELGRTLGEGTFAKVKFARNV-----ENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI 86 LGE F KV E VAIK + + + + + E + Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP--LREEFRHEAMLRARL 69 Query: 87 KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----------------LKEDE 130 +HPNV+ + V+ + + + + G+L + + L+ + Sbjct: 70 QHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 129 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT 190 Q+ ++Y S V H+DL N+L+ +K+SD GL LL Sbjct: 130 FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGN 189 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFV-LMAGYLPFEDSNLTSLYKKIF-KAE 248 + ++APE I + +D+WS GV+L+ G P+ + + + I + Sbjct: 190 SLLPIRWMAPEAIMYGKF-SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRITFAEV 280 CP A L+ + P+ R F ++ Sbjct: 249 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5WNL-A nrPDB Length = 342 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 134/315 (42%), Gaps = 18/315 (5%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 G++ +G G F +V R+V +AIK + ++ ++ E M++ K Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAK 77 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH- 146 ++ ++ + + V+E++ G L +K+ ++ L D + + +++ H Sbjct: 78 FRYILPVYGICQE--PVGLVMEYMETGSL-EKLLASEPLPWDLRFRIVHETAVGMNFLHC 134 Query: 147 -SRGVYHRDLKPENLLLDANGALKVSDFGLSAL-PQQVREDGLLHTTCGTPNYVAPEVIN 204 S + H +LKP N+LLDA+ +K+SDFGL+ D + GT Y+ PE I Sbjct: 135 MSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 205 NKGY-DGAKADLWSCGVILFVLMAGYLPFEDS-NLTSLYKKIFKAEFT-CPPWF------ 255 K K D++S ++++ ++ PF D N+ + K+ K PP Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRA 254 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGES 315 AS L++R +P R TF E+ + + P E D++ + + +S Sbjct: 255 CASLIGLMQRCWHADPQVRPTFQEI--TSETEDLCEKPDEEVKDLAHEPGEKSSLESKSE 312 Query: 316 KNLVVERREEGLKTP 330 R + P Sbjct: 313 ARPESSRLKRASAPP 327 >3EB0-A nrPDB Length = 383 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 75/335 (22%), Positives = 122/335 (36%), Gaps = 81/335 (24%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G T KY LG+TLG G+F V ++E+G A+K + ++ KN RE+ Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDI 53 Query: 83 MKLIKHPNVIRMFEVMAS--------------------------------------KTKI 104 MK++ H N+I++ + + + Sbjct: 54 MKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYL 113 Query: 105 YFVLEFVT---GGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLL 161 ++E+V L I S + + Y QL AV + HS G+ HRD+KP+NLL Sbjct: 114 NVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLL 173 Query: 162 LDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGV 220 +++ + LK+ DFG + + Y APE++ DLWS G Sbjct: 174 VNSKDNTLKLCDFGSAKKLIPSEPSVAY---ICSRFYRAPELMLGATEYTPSIDLWSIGC 230 Query: 221 ILFVLMAGYLPFEDSNLTSLYKKIFKAEFT-----------------------------C 251 + L+ G F +I + T Sbjct: 231 VFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKIL 290 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 P + A L+++IL P RI E + + +F Sbjct: 291 PEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >3LMG-A nrPDB Length = 344 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 118/269 (43%), Gaps = 12/269 (4%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL----IKHP 89 + LG G F V + G++ IK+ KV+++K Q + ++ L + H Sbjct: 36 LKVLGSGVFGTVHKGVWIPEGES--IKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHA 93 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR 148 +++R+ + + + V +++ G L D + + G L + Q+ + Y Sbjct: 94 HIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH 152 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 G+ HR+L N+LL + ++V+DFG++ L + L ++A E I+ Y Sbjct: 153 GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKY 212 Query: 209 DGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRI 266 ++D+WS GV ++ LM G P+ L + + K E P + ++ + Sbjct: 213 -THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKC 271 Query: 267 LDPNPATRITFAEVIENEWFKKGYKAPKF 295 + R TF E + NE+ + P++ Sbjct: 272 WMIDENIRPTFKE-LANEFTRMARDPPRY 299 >3QA8-A nrPDB Length = 676 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 68/225 (30%), Positives = 100/225 (44%), Gaps = 18/225 (8%) Query: 20 SSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKRE 79 S S G +E+ LG G F V + + G+ VAIK +E L K + E Sbjct: 5 SPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQE--LSPKNRERWCLE 62 Query: 80 ISTMKLIKHPNVIRMFEV------MASKTKIYFVLEFVTGGELFDKISS---NGRLKEDE 130 I MK + HPNV+ EV +A +E+ GG+L ++ LKE Sbjct: 63 IQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP 122 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDGL 187 R + +A+ Y H + HRDLKPEN++L K+ D G + ++ + L Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAK---ELDQGEL 179 Query: 188 LHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF 232 GT Y+APE++ K Y D WS G + F + G+ PF Sbjct: 180 CTEFVGTLQYLAPELLEQKKY-TVTVDYWSFGTLAFECITGFRPF 223 >6FYV-A nrPDB Length = 337 Score = 204 bits (520), Expect = 6e-53, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 121/342 (35%), Gaps = 83/342 (24%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVE-NGDNVAIKVIDKEKVLKNKMIAQ 75 P G +YE+ TLGEG F KV + +G +VA+K++ + Sbjct: 2 PHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNV----GRYREA 57 Query: 76 IKREISTMKLIKH--PN----VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK-- 127 + EI ++ + PN ++M E + V E + G +D I N L Sbjct: 58 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQ 116 Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD-------------------ANGAL 168 D R+ Q+ ++++ H + H DLKPEN+L N + Sbjct: 117 IDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDI 176 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 228 KV DFG + +D T T +Y APEVI G+ D+WS G IL G Sbjct: 177 KVVDFGSATY-----DDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLG 230 Query: 229 YLPFEDSNLTSLYKKIFKAEFTCPPWF--------------------------------- 255 + F+ + + + P Sbjct: 231 FTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKP 290 Query: 256 -----------SASAKKLIKRILDPNPATRITFAEVIENEWF 286 L++R+L+ +P RIT E +++ +F Sbjct: 291 LKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >5TOS-A nrPDB Length = 395 Score = 204 bits (519), Expect = 8e-53, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 117/314 (37%), Gaps = 37/314 (11%) Query: 2 ASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFA---------RNVE 52 A++ T S S + + + + +GEG F V Sbjct: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 Query: 53 NGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVT 112 G +A+K +++E + + EI+ + + HPN++++ V EF+ Sbjct: 98 TGLVIAVKKLNQEGF---QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 Query: 113 GGELFDKISSNG----RLKEDEARKYFQQLINAVDYCHS--RGVYHRDLKPENLLLDANG 166 G L + + G L + + HS V +RD+K N+LLDA+ Sbjct: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 Query: 167 ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM 226 K+SDFGL+ + GT Y APE + G+ A++D++S GV+L ++ Sbjct: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEIL 273 Query: 227 AGY------------------LPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 268 +G P+ S L + + P + + + L Sbjct: 274 SGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 Query: 269 PNPATRITFAEVIE 282 P +R T +V+ Sbjct: 334 FEPKSRPTMDQVVR 347 >4F0G-A nrPDB Length = 287 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 124/271 (45%), Gaps = 24/271 (8%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI----DKEKVLKNKMIAQIKREISTMK 84 + E + +G+G F V R V++ VAIK + + + + + +RE+ M Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK-ISSNGRLKEDEARKYFQQLINAVD 143 + HPN+++++ +M + + V+EFV G+L+ + + +K + + ++ Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 144 YCHSRG--VYHRDLKPENLL---LDANGAL--KVSDFGLSALPQQVREDGLLHTTCGTPN 196 Y ++ + HRDL+ N+ LD N + KV+DFGLS + + G Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ-----QSVHSVSGLLGNFQ 191 Query: 197 YVAPEVI-NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSL--YKKIFKA--EFTC 251 ++APE I + KAD +S +IL+ ++ G PF++ + + I + T Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTI 251 Query: 252 PPWFSASAKKLIKRILDPNPATRITFAEVIE 282 P + +I+ +P R F+ +++ Sbjct: 252 PEDCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >4KIK-B nrPDB Length = 677 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 64/254 (25%), Positives = 105/254 (41%), Gaps = 18/254 (7%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK 77 S S S G +E+ LG G F V N E G+ +AIK +E L + + Sbjct: 8 SWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE--LSPRNRERWC 65 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKI------YFVLEFVTGGELFDKISS---NGRLKE 128 EI M+ + HPNV+ +V + +E+ GG+L ++ L+E Sbjct: 66 LEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLRE 125 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVRED 185 + +A+ Y H + HRDLKPEN++L K+ D G + ++ + Sbjct: 126 GAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAK---ELDQG 182 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIF 245 L + GT Y+APE++ + Y D WS G + F + G+ PF + + Sbjct: 183 SLCTSFVGTLQYLAPELLEQQKY-TVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKV 241 Query: 246 KAEFTCPPWFSASA 259 + + S Sbjct: 242 RQKSEVDIVVSEDL 255 >4G3E-A nrPDB Length = 352 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 116/278 (41%), Gaps = 30/278 (10%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G+F +V ++ + G A+K + E E+ + P ++ ++ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR--------VEELVACAGLSSPRIVPLYG 133 Query: 97 VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLK 156 + + +E + GG L I G L ED A Y Q + ++Y H+R + H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 157 PENLLLDANG-ALKVSDFGLSALPQQVREDGLLHT---TCGTPNYVAPEVINNKGYDGAK 212 +N+LL ++G + DFG + Q L T GT ++APEV+ K D AK Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD-AK 252 Query: 213 ADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK---AEFTCPPWFSASAKKLIKRILDP 269 D+WS ++ ++ G P+ L KI PP + + I+ L Sbjct: 253 VDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRK 312 Query: 270 NPATRITFAEV-------------IENEWFKKGYKAPK 294 P R + E+ +++ W K YK P+ Sbjct: 313 EPVHRASAMELRRKVGKALQEVGGLKSPW-KGEYKEPR 349 >5TQX-A nrPDB Length = 655 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 77/281 (27%), Positives = 116/281 (41%), Gaps = 41/281 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 G +E+ LG G F V ++ E +AIK E L K + EI MK + H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE--LSTKNRERWCHEIQIMKKLNH 65 Query: 89 PNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISS---NGRLKEDEARKYFQQLIN 140 NV++ +V + +E+ +GG+L ++ LKE + + + Sbjct: 66 ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 141 AVDYCHSRGVYHRDLKPENLLL-DANGAL--KVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + Y H + HRDLKPEN++L D G + K+ D G + V + L GT Y Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK---DVDQGELCTEFVGTLQY 182 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLY-KKIFK---------- 246 +APE+ NK Y A D WS G ++F +AGY PF + +KI K Sbjct: 183 LAPELFENKPY-TATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACE 241 Query: 247 ---AEFTCPPWFSA--SAKKLI--------KRILDPNPATR 274 E S LI + +L+ +P R Sbjct: 242 EMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >3Q4U-A nrPDB Length = 301 Score = 198 bits (503), Expect = 6e-51, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 118/302 (39%), Gaps = 48/302 (15%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S RT L +G+G + +V G+NVA+K+ + E+ Sbjct: 1 SMQRTVARDITLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFR----ETELY 54 Query: 82 TMKLIKHPNVIRMFEVM----ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 +++H N++ S T+++ + + G L+D + L + Sbjct: 55 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT-TLDTVSCLRIVLS 113 Query: 138 LINAVDYCH--------SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--DGL 187 + + + + H + HRDLK +N+L+ NG ++D GL+ + Q D Sbjct: 114 IASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG 173 Query: 188 LHTTCGTPNYVAPEVINN----KGYDGAK-ADLWSCGVILFVLMAG----------YLPF 232 + GT Y+APEV++ +D K D+W+ G++L+ + PF Sbjct: 174 NNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPF 233 Query: 233 ED----SNLTSLYKKIFKAEFTCP----PWFSA----SAKKLIKRILDPNPATRITFAEV 280 D +K+ + P WFS S KL+K NP+ R+T + Sbjct: 234 YDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRI 293 Query: 281 IE 282 + Sbjct: 294 KK 295 >2WTK-B nrPDB Length = 373 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 80/375 (21%), Positives = 142/375 (37%), Gaps = 76/375 (20%) Query: 22 SGGRTRVGKYELGRTLGEGTF---AKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 S G YEL +G+G F V AR G+ V ++ I+ E N+M+ ++ Sbjct: 2 SSFLPEGGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQG 59 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQ 136 E+ KL HPN++ + +++ V F+ G D I ++ + E Q Sbjct: 60 ELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQ 119 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDF--GLSALPQ----QVREDGLLHT 190 ++ A+DY H G HR +K ++L+ +G + +S LS + +V D ++ Sbjct: 120 GVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS 179 Query: 191 TCGTPNYVAPEVINN--KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE 248 P +++PEV+ +GYD AK+D++S G+ L G++PF+D T + + Sbjct: 180 VKVLP-WLSPEVLQQNLQGYD-AKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGT 237 Query: 249 FTC-----------------------------------------PPW-----FSASAKKL 262 C P FS Sbjct: 238 VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHF 297 Query: 263 IKRILDPNPATRITFAEVIENEWFKKGYKA-------------PKFENADVSLDDVDAIF 309 +++ L NP R + + ++ + +FK+ + P D IF Sbjct: 298 VEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIF 357 Query: 310 DDSGESKNLVVERRE 324 + L V+ E Sbjct: 358 GLVTNLEELEVDDWE 372 >2A1A-B nrPDB Length = 284 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 117/272 (43%), Gaps = 35/272 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 ++ +G G F +V A++ +G IK + + +RE+ + + H Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHV 64 Query: 90 NVIRMFEVM----------------ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEA 131 N++ + ++ +EF G L I +L + A Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 132 RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT 191 + F+Q+ VDY HS+ + +RDLKP N+ L +K+ DFGL ++ DG + Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGL---VTSLKNDGKRTRS 181 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNLTSLYKKIFKAEFT 250 GT Y++PE I+++ Y G + DL++ G+IL L+ FE S + + + Sbjct: 182 KGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLR-----DGI 235 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 F K L++++L P R +E++ Sbjct: 236 ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >5VD3-A nrPDB Length = 311 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 114/261 (43%), Gaps = 12/261 (4%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-KHP 89 ++ LG G++ +V R+ E+G A+K K A+ E+ + + + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHP 117 Query: 90 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKEDEARKYFQQLINAVDYCHSR 148 +R+ + +Y E G L + G L E + Y + + A+ + HS+ Sbjct: 118 CCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 208 G+ H D+KP N+ L G K+ DFGL ++ G G P Y+APE++ Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGL---LVELGTAGAGEVQEGDPRYMAPELLQGS-- 231 Query: 209 DGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRIL 267 G AD++S G+ + + LP L + EFT S+ + ++ +L Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFT--AGLSSELRSVLVMML 289 Query: 268 DPNPATRITFAEVIENEWFKK 288 +P+P R T ++ ++ Sbjct: 290 EPDPKLRATAEALLALPVLRQ 310 >2H34-A nrPDB Length = 309 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 122/268 (45%), Gaps = 11/268 (4%) Query: 16 TPSGSSSGGR------TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLK 69 P GS G T+ G Y L R +G G V A + VA+K++ + Sbjct: 15 VPRGSHMDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSD 74 Query: 70 NKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKED 129 +++RE T ++ P+V+ + + ++Y + + G +L + G L Sbjct: 75 PVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPP 134 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH 189 A +Q+ +A+D H+ G HRD+KPEN+L+ A+ + DFG+++ + L + Sbjct: 135 RAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGN 194 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA-- 247 T GT Y+APE + + +AD+++ +L+ + G P++ L+ + I +A Sbjct: 195 T-VGTLYYMAPERFSE-SHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIP 252 Query: 248 -EFTCPPWFSASAKKLIKRILDPNPATR 274 T P + +I R + NP R Sbjct: 253 RPSTVRPGIPVAFDAVIARGMAKNPEDR 280 >6J5U-C nrPDB Length = 426 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 104/276 (37%), Gaps = 35/276 (12%) Query: 37 LGEGTFAKVKFARNVEN---------GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 LGEG F V + G VA+K + E + + E++ + + Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGF---QGHKEWLTEVNYLGQLS 148 Query: 88 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYC 145 HPN++ + A V EF+ G L + + G L K + + Sbjct: 149 HPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFL 208 Query: 146 HSRG--VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 H V +RD K N+LLDA+ K+SDFGL+ + GT Y APE + Sbjct: 209 HEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYV 268 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGY------------------LPFEDSNLTSLYKKIF 245 G AK+D++S GV+L L++G P+ Sbjct: 269 AT-GRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRKLFRIMDT 327 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 K P + +A L + L+P+ R +EV+ Sbjct: 328 KLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >6O6Q-A nrPDB Length = 335 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 122/299 (40%), Gaps = 53/299 (17%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-K 87 YE+ R LG G +++V ++E + V IKV+ K K IKREIS +K + Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK------IKREISILKNLVD 94 Query: 88 HPNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 PN+I M +V+ + E + D S + + R Y +L+ A+DY Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINN---IDFRSLYPTFTDYDIRFYMYELLKALDYS 151 Query: 146 HSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS G+ HRD+KP N+++D + L++ D+GL+ E + + + PE++ Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTE---YNVRVASRYFKGPELLV 208 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLP-FEDSNLTSLYKKIFK----------------- 246 + D+WS G +L ++ P F + T +I + Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNIS 268 Query: 247 --------AEFTCPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWF 286 + W S LI R+L + R+T E +++ +F Sbjct: 269 LGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >5LPZ-A nrPDB Length = 332 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 78/319 (24%), Positives = 126/319 (39%), Gaps = 35/319 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + +G G F V A + G VAIK + + + + E+ T+ IKH N Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLI---HVSGQGDREFMAEMETIGKIKHRN 74 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLINAVDYCH 146 ++ + + V EF+ G L D + + L RK + + H Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 147 ---SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLP-----FEDSNL---TSLYKKIFKAEFTCPPWF 255 K D++S GV+L L+ G P F D+NL + K+ ++ P Sbjct: 195 Q-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELM 253 Query: 256 ---SASAKKLIKR------ILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVD 306 A +L++ LD R T +V+ +K + + S + Sbjct: 254 KEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA------MFKEIQAGSGIDSQSTIR 307 Query: 307 AIFDDSGESKNLVVERREE 325 +I D + +V +E Sbjct: 308 SIEDGGFSTIEMVDMSIKE 326 >6CTH-A nrPDB Length = 309 Score = 194 bits (493), Expect = 9e-50, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 114/270 (42%), Gaps = 29/270 (10%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 95 LGEG F V ++ +A+K + + + I + E+ + ++H N++++ Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRLRHKNLVKLI 78 Query: 96 EVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR-KYFQQLINAVDYCHSRG---VY 151 + ++ V EF+ G L I L E R + + L +A+ Y H G V Sbjct: 79 GWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVL 138 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 211 HRD+K N++LD++ K+ DFGL+ L + GT Y+APE + + G Sbjct: 139 HRDIKTSNIMLDSSFNAKLGDFGLARLVDHAK-GLKKTLLAGTVGYMAPECL-SSGKASK 196 Query: 212 KADLWSCGVILFVLMAGYL---------------PF-EDSNLTSLYKKIFKAEFTCPPWF 255 ++D++S GV+ + +G P+ +S I + + Sbjct: 197 ESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGM-AFD 255 Query: 256 SASAKKL-IKRILDPNPAT--RITFAEVIE 282 + L + + +P+ R + +VI+ Sbjct: 256 PKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >5LPV-A nrPDB Length = 296 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 112/275 (40%), Gaps = 29/275 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + +G G F V A + G VAIK + + + + E+ T+ IKH N Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLI---HVSGQGDREFMAEMETIGKIKHRN 74 Query: 91 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARKYFQQLINAVDYCH 146 ++ + + V EF+ G L D + + L RK + + H Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 147 ---SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 203 S + HRD+K N+LLD N +VSDFG++ L + + T GTP YV PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 204 NNKGYDGAKADLWSCGVILFVLMAGYLP-----FEDSNL---TSLYKKIFKAEFTCPPWF 255 K D++S GV+L L+ G P F D+NL + K+ ++ P Sbjct: 195 Q-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELM 253 Query: 256 ---SASAKKLIKR------ILDPNPATRITFAEVI 281 A +L++ LD R T +V+ Sbjct: 254 KEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >3MY0-A nrPDB Length = 305 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 121/303 (39%), Gaps = 50/303 (16%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S RT + L +G+G + +V + +G++VA+K+ + EI Sbjct: 1 SMQRTVARQVALVECVGKGRYGEVWRG--LWHGESVAVKIFSSRDEQSWFR----ETEIY 54 Query: 82 TMKLIKHPNVIRMFEVMASK----TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 L++H N++ + T+++ + + G L+D + L+ A + Sbjct: 55 NTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-RQTLEPHLALRLAVS 113 Query: 138 LINAVDYCH--------SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--DGL 187 + + H + HRD K N+L+ +N ++D GL+ + Q + D Sbjct: 114 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 173 Query: 188 LHTTCGTPNYVAPEVINNK----GYDGAK-ADLWSCGVILFVLMAG----------YLPF 232 + GT Y+APEV++ + ++ K D+W+ G++L+ + PF Sbjct: 174 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 233 Query: 233 ED----SNLTSLYKKIFKAEFTCP---------PWFSASAKKLIKRILDPNPATRITFAE 279 D KK+ + P P S A+ +++ PNP+ R+T Sbjct: 234 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ-MMRECWYPNPSARLTALR 292 Query: 280 VIE 282 + + Sbjct: 293 IKK 295 >5TE0-A nrPDB Length = 347 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 129/314 (41%), Gaps = 37/314 (11%) Query: 16 TPSGSSSGGRTRVG-----KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 SG SG RV + + L EG FA V R NG A+K + Sbjct: 1 MTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNN---E 56 Query: 71 KMIAQIKREISTMKLIK-HPNVIRMFEVMASKT------KIYFVLEFVTGGELFDKISSN 123 + KREI M+ + H N++ + + ++ +++F GG++ + ++ Sbjct: 57 HDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQR 116 Query: 124 --GRLKEDEARKYFQQLINAVDYCHSRG--VYHRDLKPENLLLDANGALKVSDFGLSALP 179 E+E + F AV H + HRDLK EN+LL G + DFG + Sbjct: 117 LQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNK 176 Query: 180 QQVREDGLLHTT------CGTPNYVAPEVINNK--GYDGAKADLWSCGVILFVLMAGYLP 231 Q + ++ T +Y APE++N KAD+W+ G +L+ L LP Sbjct: 177 FQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLP 236 Query: 232 FEDSNLTSLYKKIFKAEFTCPPW--FSASAKKLIKRILDPNPATRITFAEVIENEW--FK 287 F +S + I FT P +S LI+ +L+P+P R +V + K Sbjct: 237 FGESQVA-----ICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLK 291 Query: 288 KGYKAPKFENADVS 301 K P +N+ + Sbjct: 292 KECPIPNVQNSPIP 305 >5AR8-A nrPDB Length = 326 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 102/267 (38%), Gaps = 19/267 (7%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 R L G V AR+ + VA+K + L + + RE + + ++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLK---EDEARKYFQQLINAVDYCHSR-- 148 + + + V E++ G L + + + ++ V+Y H+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTC---GTPNYVAPEVIN- 204 + H DLK +N+LLD +K++DFGLS + GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 205 -NKGYDGAKADLWSCGVILFVLMAGYLPFED-SNLTSLYKKIFKAEFT------CPPWFS 256 K K D++S VI + +++ PFED +N + + + P Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 276 Query: 257 ASAK--KLIKRILDPNPATRITFAEVI 281 A+ LI+ NP R +F + + Sbjct: 277 HRARMISLIESGWAQNPDERPSFLKCL 303 >3RAW-A nrPDB Length = 381 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 80/368 (21%), Positives = 125/368 (33%), Gaps = 88/368 (23%) Query: 4 RTTPSRSTPSRSTPSGSSSGGRTRVG-----KYELGRTLGEGTFAKVKFARNVENGD-NV 57 ++ S SRS R+G +YE+ LGEGTF KV + G V Sbjct: 21 QSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQV 80 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN------VIRMFEVMASKTKIYFVLEFV 111 A+K+I K + EI+ +K IK + + M + + E + Sbjct: 81 ALKIIRNV----GKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELL 136 Query: 112 TGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA----- 164 F+ + N R QL +A+ + H + H DLKPEN+L Sbjct: 137 GKNT-FEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFET 195 Query: 165 --------------NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 210 N +++V+DFG + + T T +Y PEVI G+ Sbjct: 196 LYNEHKSCEEKSVKNTSIRVADFGSATFDHE-----HHTTIVATRHYRPPEVILELGW-A 249 Query: 211 AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW---------------- 254 D+WS G ILF G+ F+ + K P Sbjct: 250 QPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGL 309 Query: 255 -----------FSASAK-----------------KLIKRILDPNPATRITFAEVIENEWF 286 + K L++R+L+ +PA RIT AE + + +F Sbjct: 310 VWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 Query: 287 KKGYKAPK 294 + Sbjct: 370 AGLTPEER 377 >3UIU-A nrPDB Length = 306 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 64/285 (22%), Positives = 117/285 (41%), Gaps = 48/285 (16%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 ++ +G G F +V A++ +G I+ + + +RE+ + + H Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHV 65 Query: 90 NVIRMFEVM-----------------------------ASKTKIYFVLEFVTGGELFDKI 120 N++ + ++ +EF G L I Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 121 SSNG--RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL 178 +L + A + F+Q+ VDY HS+ + HRDLKP N+ L +K+ DFGL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGL--- 182 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM-AGYLPFEDSNL 237 ++ DG + GT Y++PE I+++ Y G + DL++ G+IL L+ FE S Sbjct: 183 VTSLKNDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKF 241 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 + + + F K L++++L P R +E++ Sbjct: 242 FTDLR-----DGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >5UNP-A nrPDB Length = 369 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 82/368 (22%), Positives = 136/368 (36%), Gaps = 88/368 (23%) Query: 13 SRSTPSGSSSGGRTRVG-----KYELGRTLGEGTFAKVKFAR-NVENGDNVAIKVIDKEK 66 ++S + VG +YE+ TLGEGTF +V + G VA+K+I + Sbjct: 13 AKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE 72 Query: 67 VLKNKMIAQIKREISTMKLI-----KHPNV-IRMFEVMASKTKIYFVLEFVTGGELFDKI 120 K + EI+ ++ I + N+ ++MF+ + E + G FD + Sbjct: 73 KYK----EAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFL 127 Query: 121 SSNGRLK--EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG------------ 166 N L + R QL AV + H + H DLKPEN+L + Sbjct: 128 KDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRD 187 Query: 167 -------ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCG 219 A++V DFG + + T T +Y APEVI G+ D+WS G Sbjct: 188 ERSVKSTAVRVVDFGSATFDHE-----HHSTIVSTRHYRAPEVILELGW-SQPCDVWSIG 241 Query: 220 VILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP-------------------------- 253 I+F G+ F+ + + + P Sbjct: 242 CIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAG 301 Query: 254 ------------WFSASAK------KLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 + ++ A+ LI+ +L+ PA R+T E +++ +F + P Sbjct: 302 RYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 Query: 296 ENADVSLD 303 + D S D Sbjct: 362 KLWDSSRD 369 >2Y4I-B nrPDB Length = 319 Score = 190 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 127/298 (42%), Gaps = 28/298 (9%) Query: 1 MASRTTPSRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIK 60 + S + R S S + E+G +G+G F +V R VAI+ Sbjct: 8 LLSARSFPRKA---SQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIR 61 Query: 61 VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKI 120 +ID E+ ++++ A KRE+ + +H NV+ S + + G L+ + Sbjct: 62 LIDIERDNEDQLKA-FKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVV 120 Query: 121 SSNG-RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL---S 176 L ++ R+ Q+++ + Y H++G+ H+DLK +N+ D NG + ++DFGL S Sbjct: 121 RDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSIS 179 Query: 177 ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK--------ADLWSCGVILFVLMAG 228 + Q R + L G ++APE+I D + +D+++ G I + L A Sbjct: 180 GVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR 239 Query: 229 YLPFEDSNLTSLYKKIFKAEFTCPPWFS-----ASAKKLIKRILDPNPATRITFAEVI 281 PF+ ++ I++ P S ++ R TF +++ Sbjct: 240 EWPFKTQPAEAI---IWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM 294 >2WO6-A nrPDB Length = 382 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 121/290 (41%), Gaps = 41/290 (14%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G + +YE+ +G+G+F +V A + + VAIK+I +K + Q + E+ Sbjct: 48 NGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF----LNQAQIEVRL 103 Query: 83 MKLIK-HP-----NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKY 134 ++L+ H ++ + + + V E ++ L+D + + + + RK+ Sbjct: 104 LELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKF 162 Query: 135 FQQLINAVDYCHSR--GVYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHT 190 QQ+ A+ + + + H DLKPEN+LL +K+ DFG S Q ++ Sbjct: 163 AQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ-----RIYQ 217 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT 250 + Y +PEV+ YD D+WS G IL + G F +N KI + Sbjct: 218 YIQSRFYRSPEVLLGMPYD-LAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGI 276 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF-------KKGYKAP 293 P LD P R F ++ + W K+ YK P Sbjct: 277 PPAHI-----------LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPP 315 Score = 41.5 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 13/30 (43%), Positives = 19/30 (63%) Query: 259 AKKLIKRILDPNPATRITFAEVIENEWFKK 288 K LI R+LD +P TRI +++ +FKK Sbjct: 349 FKDLILRMLDYDPKTRIQPYYALQHSFFKK 378 >5IKW-A nrPDB Length = 310 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 127/297 (42%), Gaps = 37/297 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-H 88 + L +L EG F+ V R G A+K + + + KREI+ MK + H Sbjct: 15 QVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVC---KREITIMKELSGH 70 Query: 89 PNVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINA 141 N++ + + ++ ++E+ G++ ++++ E E + F A Sbjct: 71 KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEA 130 Query: 142 VDYCHSRG--VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLH------TTCG 193 V H + HRDLK EN+LL+ G + DFG + + ++ Sbjct: 131 VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 194 TPNYVAPEVIN--NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC 251 T +Y APE+IN KAD+W+ G +L+ L LPF +S + I FT Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA-----ICDGNFTI 245 Query: 252 PPW--FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVD 306 P +S + LI+ +L+P+P R F+ Y A KF AD + +++ Sbjct: 246 PDNSRYSRNIHCLIRFMLEPDPEHRPDI--------FQVSYFAFKFAAADCPVSNIN 294 >2BUJ-A nrPDB Length = 317 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 115/275 (41%), Gaps = 27/275 (9%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y + LGEG F+ V + +G A+K I + + + +RE +L H Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL---CHEQQDREEAQREADMHRLFNH 85 Query: 89 PNVIRMFEVMAS----KTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLIN 140 PN++R+ K + + +L F G L+++I L ED+ + Sbjct: 86 PNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICR 145 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL----SALPQQVREDGLLHTTCG--- 193 ++ H++G HRDLKP N+LL G + D G + R+ L Sbjct: 146 GLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC 205 Query: 194 TPNYVAPEVINNKGYD--GAKADLWSCGVILFVLMAGYLPFE-----DSNLTSLYKKIFK 246 T +Y APE+ + + + + D+WS G +L+ +M G P++ ++ + + Sbjct: 206 TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQN--Q 263 Query: 247 AEFTCPPWFSASAKKLIKRILDPNPATRITFAEVI 281 P S++ +L+ ++ +P R ++ Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 >2RIO-A nrPDB Length = 434 Score = 187 bits (476), Expect = 7e-48, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 120/297 (40%), Gaps = 43/297 (14%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVI 92 + LG G+ V F + G VA+K + + EI + HPNVI Sbjct: 20 EKILGYGSSGTVVF-QGSFQGRPVAVKRMLID------FCDIALMEIKLLTESDDHPNVI 72 Query: 93 RMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR-------KYFQQLINAVDYC 145 R + + +Y LE L D + S E+ +Q+ + V + Sbjct: 73 RYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 146 HSRGVYHRDLKPENLLLD-------------ANGALKVSDFGLSALPQQVRED--GLLHT 190 HS + HRDLKP+N+L+ N + +SDFGL + L+ Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 191 TCGTPNYVAPEVINN------KGYDGAKADLWSCGVILFVLMA-GYLPFED--SNLTSLY 241 GT + APE++ K D++S G + + +++ G PF D S +++ Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNII 251 Query: 242 KKIFKA-EFTCPPWFS--ASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKF 295 + IF E C S A A LI +++D +P R T +V+ + F K +F Sbjct: 252 RGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEF 308 >4JLC-A nrPDB Length = 657 Score = 187 bits (476), Expect = 7e-48, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD A+KV + L+ + RE +K + H N Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 67 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELFDKISSNGR---LKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ + L E E + ++ +++ Sbjct: 68 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 146 HSRGVYHRDLKPENLL--LDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HRD+KP N++ + +G K++DFG + ++ +D + GT Y+ P+ Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPD 184 Query: 202 VIN-------NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFT 250 + ++ GA DLWS GV + G LPF + KI + + Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >3MDY-A nrPDB Length = 337 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 118/295 (40%), Gaps = 48/295 (16%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 RT + ++ + +G+G + +V + G+ VA+KV + + EI Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVF----FTTEEASWFRETEIYQT 85 Query: 84 KLIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 139 L++H N++ S T++Y + ++ G L+D + S L K + Sbjct: 86 VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSV 144 Query: 140 NAVDYCH--------SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE--DGLLH 189 + + + H + HRDLK +N+L+ NG ++D GL+ D + Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 190 TTCGTPNYVAPEVINNKGY-----DGAKADLWSCGVILFVLMAG----------YLPFED 234 T GT Y+ PEV++ AD++S G+IL+ + LP+ D Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHD 264 Query: 235 ----SNLTSLYKKIF---KAEFTCPPWFSAS-----AKKLIKRILDPNPATRITF 277 ++I K + P +S+ KL+ NPA+R+T Sbjct: 265 LVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >4EUU-A nrPDB Length = 319 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELFDKISSNGR---LKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ + L E E + ++ +++ Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 146 HSRGVYHRDLKPENLL--LDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HR++KP N++ + +G K++DFG + ++ +D + GT Y+ P+ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPD 185 Query: 202 VIN-------NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFT 250 + ++ GA DLWS GV + G LPF + KI + + Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >4EUT-A nrPDB Length = 396 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELFDKISSNGR---LKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ + L E E + ++ +++ Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 146 HSRGVYHRDLKPENLL--LDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HR++KP N++ + +G K++DFG + ++ +D + GT Y+ P+ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPD 185 Query: 202 VIN-------NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFT 250 + ++ GA DLWS GV + G LPF + KI + + Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >2PMN-X nrPDB Length = 348 Score = 184 bits (468), Expect = 7e-47, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 50/305 (16%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI-------------- 73 + Y + RTL +G F K+ ++ A+K +K + K + Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 74 AQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK------ISSN--GR 125 K E+ + IK+ + ++ + ++Y + E++ + + N Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 126 LKEDEARKYFQQLINAVDYCH-SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 + + + ++N+ Y H + + HRD+KP N+L+D NG +K+SDFG S + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGES----EYMV 203 Query: 185 DGLLHTTCGTPNYVAPEVI-NNKGYDGAKADLWSCGVILFVLMAGYLPFE-DSNLTSLYK 242 D + + GT ++ PE N Y+GAK D+WS G+ L+V+ +PF +L L+ Sbjct: 204 DKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFN 263 Query: 243 KIFKAEFTCP-------------------PWFSASAKKLIKRILDPNPATRITFAEVIEN 283 I P + S +K L NPA RIT + +++ Sbjct: 264 NIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKH 323 Query: 284 EWFKK 288 EW Sbjct: 324 EWLAD 328 >2PVN-A nrPDB Length = 352 Score = 183 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 118/301 (39%), Gaps = 52/301 (17%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 YE+ R +G G +++V NV N + + + K + L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEKC-----IIKILKPVKKKKIKREIKILQNLCGG 106 Query: 89 PNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 PN++++ +++ + + E+V + F + L + + R Y +L+ A+DYCH Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVL--YPTLTDYDIRYYIYELLKALDYCH 163 Query: 147 SRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 205 S+G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ + Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKE---YNVRVASRYFKGPELLVD 220 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLP-FEDSNLTSLYKKIFK------------------ 246 D+WS G + ++ P F + KI K Sbjct: 221 LQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIEL 280 Query: 247 --------AEFTCPPWF-----------SASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + PW S A + ++L + R+T E + + +F+ Sbjct: 281 DPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQ 340 Query: 288 K 288 + Sbjct: 341 Q 341 >6O8B-A nrPDB Length = 665 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 25/240 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 74 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELFDKISSNGR---LKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ + L E E + ++ +++ Sbjct: 75 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 134 Query: 146 HSRGVYHRDLKPENLL--LDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HR++KP N++ + +G K++DFG + ++ +D GT Y+ P+ Sbjct: 135 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVELYGTEEYLHPD 191 Query: 202 VIN-------NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFT 250 + ++ GA DLWS GV + G LPF + KI + + Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >6NT9-A nrPDB Length = 742 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + L LG+G A V R+ + GD AIKV + L+ + RE +K + H N Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 Query: 91 VIRMFEVMASKTKIY--FVLEFVTGGELFDKISSNGR---LKEDEARKYFQQLINAVDYC 145 ++++F + T + ++EF G L+ + L E E + ++ +++ Sbjct: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 146 HSRGVYHRDLKPENLL--LDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 G+ HR++KP N++ + +G K++DFG + ++ +D + GT Y+ P+ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAR---ELEDDEQFVSLYGTEEYLHPD 183 Query: 202 VIN-------NKGYDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFT 250 + ++ GA DLWS GV + G LPF + KI + + Sbjct: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >5VC6-A nrPDB Length = 289 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 108/290 (37%), Gaps = 35/290 (12%) Query: 19 GSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKR 78 G+ S ++ +G G F V +G AIK K+ + + R Sbjct: 1 GAGSMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALR 59 Query: 79 EISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR----LKEDEARK 133 E+ ++ +H +V+R F A + E+ GG L D IS N R KE E + Sbjct: 60 EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANG-------------------ALKVSDFG 174 Q+ + Y HS + H D+KP N+ + K+ D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 175 LSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED 234 + + G ++A EV+ KAD+++ + + V AG P Sbjct: 180 HVTRISSPQVEE------GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP- 231 Query: 235 SNLTSLYKKIFKAEFT-CPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + +I + P S +L+K ++ P+P R + ++++ Sbjct: 232 -RNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >1PY5-A nrPDB Length = 326 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 126/315 (40%), Gaps = 57/315 (18%) Query: 16 TPSGSSSG-----GRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKN 70 T SGS SG RT L ++G+G F +V + G+ VA+K+ + Sbjct: 11 TTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIF------SS 62 Query: 71 KMIAQIKREISTMK--LIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFDKISSNG 124 + RE + +++H N++ + T+++ V ++ G LFD ++ Sbjct: 63 REERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT 122 Query: 125 RLKEDEARKYFQQLINAVDYCH--------SRGVYHRDLKPENLLLDANGALKVSDFGLS 176 E + + + + H + HRDLK +N+L+ NG ++D GL+ Sbjct: 123 VTVEGMIK-LALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA 181 Query: 177 ALPQQVRE--DGLLHTTCGTPNYVAPEV----INNKGYDGAK-ADLWSCGVILFVLMAG- 228 + D + GT Y+APEV IN K ++ K AD+++ G++ + + Sbjct: 182 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC 241 Query: 229 ---------YLPFED----SNLTSLYKKIFKAEFTCP----PWFSASA----KKLIKRIL 267 LP+ D +K+ + P W S A K+++ Sbjct: 242 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW 301 Query: 268 DPNPATRITFAEVIE 282 N A R+T + + Sbjct: 302 YANGAARLTALRIKK 316 >5L2Q-C nrPDB Length = 320 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 80/310 (25%), Positives = 135/310 (43%), Gaps = 50/310 (16%) Query: 18 SGSSSGGRTRVGKYELGRTLGEGTFAKV-----KFARNVENGDNVAIKVIDKEKVLKNKM 72 SG S R G + LG LG + V AR D +K++ E+ + Sbjct: 3 SGISGNNAKRAGPFILGPRLGN---SPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGI 59 Query: 73 IAQIKR--------EISTMKLIK-HPNVIRMFEVMASKT------------------KIY 105 +Q +R E S + L+ V+ + +T +I Sbjct: 60 ESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRIC 119 Query: 106 FVLEFVTGGE----------LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 VL+ + + L + RL E E F ++ V+ H + + HRDL Sbjct: 120 LVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDL 179 Query: 156 KPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 K N++L+ + +++F L V E LL G+P Y++P+V++ + Y G +D Sbjct: 180 KLGNMVLNKRTHRITITNFCLGK--HLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSD 237 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP--WFSASAKKLIKRILDPNPA 272 +W+ GV+LF ++ G PF DS L++KI AE+T P S + LI+++L +P Sbjct: 238 MWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQ 297 Query: 273 TRITFAEVIE 282 R+ A+V+E Sbjct: 298 QRLAAADVLE 307 >4MD7-E nrPDB Length = 391 Score = 180 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 123/300 (41%), Gaps = 54/300 (18%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y+L R LG G +++V A N+ N + K+LK +IKREI ++ ++ Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 90 Query: 89 -PNVIRMFEVMASK--TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 PN+I + +++ V E V + L + + R Y +++ A+DYC Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 147 Query: 146 HSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLV 204 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL--------------TSLYKKIFKAEFT 250 + D+WS G +L ++ PF + LY I K Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 251 CPPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWF 286 P F S A + ++L + +R+T E +E+ +F Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >3UIM-A nrPDB Length = 326 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 113/285 (39%), Gaps = 41/285 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 + LG G F KV R + +G VA+K + +E+ ++ Q + E+ + + H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGEL--QFQTEVEMISMAVH 86 Query: 89 PNVIRMFEVMASKTKIYFVLEFVTGGE----LFDKISSNGRLKEDEARKYFQQLINAVDY 144 N++R+ + T+ V ++ G L ++ S L + ++ + Y Sbjct: 87 RNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 145 CHSR---GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 H + HRD+K N+LLD V DFGL+ L ++ + GT ++APE Sbjct: 147 LHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLM-DYKDTHVTTAVRGTIGHIAPE 205 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFE---------------------DSNLTSL 240 + + G K D++ GV+L L+ G F+ + L +L Sbjct: 206 YL-STGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEAL 264 Query: 241 YKKIFKAEFTCPPWFSASAKKLIK---RILDPNPATRITFAEVIE 282 + + ++LI+ +P R +EV+ Sbjct: 265 VDVDLQGNYK-----DEEVEQLIQVALLCTQSSPMERPKMSEVVR 304 >6HMD-A nrPDB Length = 365 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 130/318 (40%), Gaps = 57/318 (17%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y+L R LG G +++V A N+ N + K+LK +IKRE+ ++ ++ Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKIKREVKILENLRG 106 Query: 89 -PNVIRMFEVMASK--TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 N+I++ + + V E++ + L + + R Y +L+ A+DYC Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYC 163 Query: 146 HSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS+G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLV 220 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL--------------TSLYKKIFKAEFT 250 + D+WS G +L ++ PF LY + K Sbjct: 221 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 280 Query: 251 CPPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWF 286 P F S A L+ ++L + R+T E +E+ +F Sbjct: 281 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 Query: 287 ---KKGYKAPKFENADVS 301 K P +NA +S Sbjct: 341 YPVVKEQSQPSADNAVLS 358 >4CRL-A nrPDB Length = 406 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 75/362 (20%), Positives = 132/362 (36%), Gaps = 77/362 (21%) Query: 22 SGGRTRVGK---YELGRTLGEGTFAKVKFARNVENGDN--VAIKVIDKEKVLKNKMIAQI 76 S R RV YE + G GT+ V A+ + D+ A+K I+ + + Sbjct: 13 SSERERVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS-----A 66 Query: 77 KREISTMKLIKHPNVIRMFEVMAS--KTKIYFVLEFVTGGELFDKIS---------SNGR 125 REI+ ++ +KHPNVI + +V S K++ + ++ +L+ I + Sbjct: 67 CREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQ 125 Query: 126 LKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD----ANGALKVSDFGLSALPQQ 181 L + Q+++ + Y H+ V HRDLKP N+L+ G +K++D G + L Sbjct: 126 LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNS 185 Query: 182 -VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE------- 233 ++ L T Y APE++ + D+W+ G I L+ F Sbjct: 186 PLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIK 245 Query: 234 --DSNLTSLYKKIFKAEFTCP-----------PWFSASAKK------------------- 261 + +IF P P S K Sbjct: 246 TSNPYHHDQLDRIFNV-MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHK 304 Query: 262 ---------LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDS 312 L++++L +P RIT + +++ +F + A + F Sbjct: 305 VKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTE 364 Query: 313 GE 314 E Sbjct: 365 EE 366 >5XVU-A nrPDB Length = 332 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 126/306 (41%), Gaps = 54/306 (17%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +YE+ + +G G +++V + E A KVLK +IKREI ++ + Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKKKKIKREIKILQNLNG 84 Query: 89 -PNVIRMFEVMASK--TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 PN+I++ +++ + E++ + + + + R Y Q++ A+DYC Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALDYC 141 Query: 146 HSRGVYHRDLKPENLLLD-ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS+G+ HRD+KP N+++D N +++ +GL+ +E + + Y PE++ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQE---YNVRVASRYYKGPELLI 198 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLP-FEDSNLTSLYKKIFK----------------- 246 + D+WS G +L ++ P F + KI K Sbjct: 199 DLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIK 258 Query: 247 ---------AEFTCPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWF 286 E+ PW LI ++L + A RI E +E+ +F Sbjct: 259 LKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYF 318 Query: 287 KKGYKA 292 ++ + Sbjct: 319 REVREE 324 >3SOC-A nrPDB Length = 322 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 116/287 (40%), Gaps = 48/287 (16%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 +L G F V A+ + + VA+K+ +++K Q + E+ ++ +KH N+ Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFP----IQDKQSWQNEYEVYSLPGMKHENI 80 Query: 92 IRMFEVMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 ++ T ++ + F G L D + +N + +E + + + Y H Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN-VVSWNELCHIAETMARGLAYLHE 139 Query: 148 ----------RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNY 197 + HRD+K +N+LL N ++DFGL+ + + G H GT Y Sbjct: 140 DIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 198 VAPEVINNKGYDGA----KADLWSCGVILFVLMAGY-----------LPFEDS-----NL 237 +APEV+ + D+++ G++L+ L + LPFE+ +L Sbjct: 200 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 259 Query: 238 TSLYKKIF--KAEFTCPPWFSASA-----KKLIKRILDPNPATRITF 277 + + + K ++ A + I+ D + R++ Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >6EII-A nrPDB Length = 352 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 123/300 (41%), Gaps = 54/300 (18%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 Y+L R LG G +++V A N+ N + K+LK +IKREI ++ ++ Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 113 Query: 89 -PNVIRMFEVMASK--TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 PN+I + +++ V E V + L + + R Y +++ A+DYC Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 170 Query: 146 HSRGVYHRDLKPENLLLDANGA-LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVIN 204 HS G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE---YNVRVASRYFKGPELLV 227 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL--------------TSLYKKIFKAEFT 250 + D+WS G +L ++ PF + LY I K Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 251 CPPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWF 286 P F S A + ++L + +R+T E +E+ +F Sbjct: 288 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4M66-A nrPDB Length = 325 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 132/322 (40%), Gaps = 39/322 (12%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQI 76 P+G+S+ + + +G+G F V A + +VA+K+++ +K I Sbjct: 8 PTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKK---------I 58 Query: 77 KREISTMKLIKHPNVIRMFEVMASKTKIY-----FVLEFVTGGELFDKISSNGRLKEDEA 131 E+ M +++ NV+ + V + V F+ G L + Sbjct: 59 SWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLL 118 Query: 132 RKYFQQLINAVDYCHS--RGVYHRDLKPENLLLDANGALKVSDFGLSAL----PQQVRED 185 + Q+++ + Y HS + HRDLKP N+LLD K++DFGLS Sbjct: 119 CRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSG 178 Query: 186 GLLHTTCGTPNYVAPEVINN-KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKI 244 + GT Y+ PE++ +D++S G++++ ++AG E + TSL ++ Sbjct: 179 SGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREA-ELVDKTSLIRET 237 Query: 245 FKAEFTCPPWF-----SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENAD 299 + PP S L +++ E++ + W + P F++ + Sbjct: 238 VCDRQSRPPLTELPPGSPETPGL-EKL-----------KELMIHCWGSQSENRPSFQDCE 285 Query: 300 VSLDDVDAIFDDSGESKNLVVE 321 ++V + D ++ V+ Sbjct: 286 PKTNEVYNLVKDKVDAAVSEVK 307 >4M69-B nrPDB Length = 283 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 97/250 (38%), Gaps = 12/250 (4%) Query: 43 AKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIRMFEVMASK 101 + + + V IKV + + ++ EI TMK PN++R+F + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 102 T----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKP 157 T + V+E+ G L + + L + + H HR++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 140 Query: 158 ENLLLDANGALKVSDFGLSALPQQVREDGLLH--TTCGTPNYVAPEVINNKGY-DGAKAD 214 + L+ +K++ F LS + + YV+PE + N KA+ Sbjct: 141 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 200 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPA 272 ++S G++L+ + G +PFE + + + + + + P +++I P+ Sbjct: 201 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 260 Query: 273 TRITFAEVIE 282 R + ++E Sbjct: 261 QRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 97/250 (38%), Gaps = 12/250 (4%) Query: 43 AKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIRMFEVMASK 101 + + + V IKV + + ++ EI TMK PN++R+F + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 102 T----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKP 157 T + V+E+ G L + + L + + H HR++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 326 Query: 158 ENLLLDANGALKVSDFGLSALPQQVREDGLLH--TTCGTPNYVAPEVINNKGY-DGAKAD 214 + L+ +K++ F LS + + YV+PE + N KA+ Sbjct: 327 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 386 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPA 272 ++S G++L+ + G +PFE + + + + + + P +++I P+ Sbjct: 387 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 446 Query: 273 TRITFAEVIE 282 R + ++E Sbjct: 447 QRPSVDGILE 456 >5XD6-A nrPDB Length = 305 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 55/236 (23%), Positives = 89/236 (37%), Gaps = 18/236 (7%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV 67 S + + R Y +GEG++ +V + +G AIK +D K Sbjct: 1 HHHHQPISVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQ 59 Query: 68 LKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-- 125 + +AQ +S + ++ NV+ + E+ G L D + Sbjct: 60 PDQEFLAQ----VSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVK 115 Query: 126 -------LKEDEARKYFQQLINAVDYCHSR---GVYHRDLKPENLLLDANGALKVSDFGL 175 L + K ++Y H + V HRD+K N+LL + K++DF L Sbjct: 116 GAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDL 175 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLP 231 S + GT Y APE G K+D++S GV+L L+ G P Sbjct: 176 SNQAPDMAARLHSTRVLGTFGYHAPEYAMT-GTLSTKSDVYSFGVVLLELLTGRKP 230 >5E8V-A nrPDB Length = 316 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 120/302 (39%), Gaps = 51/302 (16%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENG----DNVAIKVIDKEKVLKNKMIAQIKR 78 T + EL +G+G FA+V A+ +N + VA+K+ E+ K I Sbjct: 3 MHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 62 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKI----YFVLEFVTGGELFDKISSNGRLKEDEARKY 134 +I+ +KH N+++ KT++ + + F G L + ++ + + ++ RK Sbjct: 63 DIN----LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKL 117 Query: 135 FQQLINAVDYCHS---------RGVYHRDLKPENLLLDANGALKVSDFGLS-ALPQQVRE 184 L + + HS + HRDLK N+L+ + + DFGLS L + Sbjct: 118 GSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSV 177 Query: 185 DGLLHT-TCGTPNYVAPEVI-----NNKGYDGAKADLWSCGVILFVLMAG---------- 228 D L ++ GT Y+APEV+ + D++S ++L+ + + Sbjct: 178 DDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDY 237 Query: 229 YLPF-----EDSNLTSLYKKIF--KAEFTCPPWFSAS-----AKKLIKRILDPNPATRIT 276 PF E + S+ + P ++ + + D +P R+T Sbjct: 238 EPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLT 297 Query: 277 FA 278 Sbjct: 298 AQ 299 >2QKW-B nrPDB Length = 321 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 112/266 (42%), Gaps = 26/266 (9%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 +G G F KV + +G VA+K + ++ I + + EI T+ +HP+++ + Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIG 102 Query: 97 VMASKTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 + ++ + +++ G L + + ++ + + Y H+R + H Sbjct: 103 FCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIH 162 Query: 153 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 212 RD+K N+LLD N K++DFG+S ++ + L GT Y+ PE KG K Sbjct: 163 RDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI-KGRLTEK 221 Query: 213 ADLWSCGVILFVLMAGY------LPFE---------DSNLTSLYKKIFKAEF--TCPPWF 255 +D++S GV+LF ++ LP E +S+ ++I P Sbjct: 222 SDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPES 281 Query: 256 SASAKKLIKRILDPNPATRITFAEVI 281 + L + R + +V+ Sbjct: 282 LRKFGDTAVKCLALSSEDRPSMGDVL 307 >4MWI-A nrPDB Length = 294 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 98/238 (41%), Gaps = 12/238 (5%) Query: 57 VAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKHPNVIRMFEVMASKT----KIYFVLEFV 111 VAIKV K + ++ Q +EI TMK + PN++R+F + +T + V+E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 112 TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV--YHRDLKPENLLLDANGALK 169 G L + + L + + H H ++ N L+ +K Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 170 VSDFGLSAL--PQQVREDGLLHTTCGTPNYVAPEVINNKGY-DGAKADLWSCGVILFVLM 226 ++ F L + + Y++P+ + + Y K++++S G++L+ + Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIA 229 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEVIE 282 G +PF+ N + K + P + +++I +P+ R + E+++ Sbjct: 230 TGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >4NT4-A nrPDB Length = 312 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 132/323 (40%), Gaps = 46/323 (14%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-KH- 88 + +G+ +G G F +++ +N+ N ++VAIK+ + Q+ E KL+ H Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKS-----KAPQLHLEYRFYKLLGSHA 68 Query: 89 ----PNVIRMFEVMASKTKIY-FVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINA 141 + R++ + + VLE + + +LF+ + + +QL++ Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICAR--KFSLKTVLMIAKQLLHR 126 Query: 142 VDYCHSRGVYHRDLKPENLLLDANGA-----LKVSDFGLSALPQQVREDGLL-----HTT 191 ++Y HSR + +RD+KPEN L+ + + DFGL+ + + + + Sbjct: 127 IEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSL 186 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAE 248 GT Y++ + + DL + G + + G LP++ L Y+KI + Sbjct: 187 TGTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 245 Query: 249 FTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAI 308 P I+ + D +P T+ + F ++ P ++ D+ Sbjct: 246 RATP----------IEVLCDGHPEEFATYLRYVRRLDF---FETPDYDFLRRLFQDL--- 289 Query: 309 FDDSGESKNLVVERREEGLKTPV 331 FD G + + + + TPV Sbjct: 290 FDRKGYTDEGEFDWTGKTMSTPV 312 >2QLU-A nrPDB Length = 314 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 120/298 (40%), Gaps = 49/298 (16%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 81 S G G +L G F V A+ + D VA+K+ L++K Q +REI Sbjct: 8 SSGLVPRGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIFP----LQDKQSWQSEREIF 61 Query: 82 TMKLIKHPNVIRMFEVMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQ 137 + +KH N+++ + +++ + F G L D + N + +E + Sbjct: 62 STPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN-IITWNELCHVAET 120 Query: 138 LINAVDYCHS-----------RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG 186 + + Y H + HRD K +N+LL ++ ++DFGL+ + + G Sbjct: 121 MSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPG 180 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGA----KADLWSCGVILFVLMAGY-----------LP 231 H GT Y+APEV+ + D+++ G++L+ L++ LP Sbjct: 181 DTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLP 240 Query: 232 FEDS-----NLTSLYKKIF--KAEFTCPPWF--SASAKKL---IKRILDPNPATRITF 277 FE+ +L L + + K T + +L I+ D + R++ Sbjct: 241 FEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >2JD5-A nrPDB Length = 373 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 70/371 (18%), Positives = 137/371 (36%), Gaps = 89/371 (23%) Query: 23 GGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G + +Y L R LG G F+ V A+++ N +VA+K++ +KV + EI Sbjct: 13 GEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYT----EAAEDEIKL 68 Query: 83 MKLIKHP-----------NVIRMFEVMASKT----KIYFVLEFVTGGELFDKISS--NGR 125 ++ + +++++ + K + V E V G L I + Sbjct: 69 LQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRG 127 Query: 126 LKEDEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANG------ALKVSDFGLSAL 178 + ++ +QL+ +DY H R G+ H D+KPEN+L++ +K++D G + Sbjct: 128 IPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACW 187 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE----- 233 D + T Y +PEV+ + G AD+WS ++F L+ G FE Sbjct: 188 Y-----DEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGH 241 Query: 234 -----DSNLTSLYKKIFK--------------------------------------AEFT 250 D ++ + + + + ++ Sbjct: 242 SYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYK 301 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFK-----KGYKAPKFENADVSLDDV 305 + + +L +P R ++ + W K + + P E S D+ Sbjct: 302 FSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYG-SGSDI 360 Query: 306 DAIFDDSGESK 316 F++ + K Sbjct: 361 PGWFEEVRDHK 371 >3REP-A nrPDB Length = 271 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 52/264 (19%), Positives = 111/264 (42%), Gaps = 20/264 (7%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 + L E ++ R G+++ +KV+ K + + E +++ Sbjct: 9 FKQLNFLTKLNENHSGELWKGR--WQGNDIVVKVL-KVRDWSTRKSRDFNEECPRLRIFS 65 Query: 88 HPNVIRMFEVMASKT--KIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVD 143 HPNV+ + S + ++ G L++ + N + + +A K+ + + Sbjct: 66 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 125 Query: 144 YCHSRG--VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 201 + H+ + L ++++D + ++S ++ + + G ++ P +VAPE Sbjct: 126 FLHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYA----PAWVAPE 178 Query: 202 VINNKGYDG--AKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--EFTCPPWFSA 257 + K D AD+WS V+L+ L+ +PF D + + K+ T PP S Sbjct: 179 ALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISP 238 Query: 258 SAKKLIKRILDPNPATRITFAEVI 281 KL+K ++ +PA R F ++ Sbjct: 239 HVSKLMKICMNEDPAKRPKFDMIV 262 >3VHK-A nrPDB Length = 368 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 38/162 (23%), Positives = 73/162 (45%), Gaps = 4/162 (2%) Query: 125 RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 L + Y Q+ +++ SR HRDL N+LL +K+ DFGL+ + + Sbjct: 196 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 255 Query: 185 DGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKK 243 ++APE I ++ Y ++D+WS GV+L+ + + G P+ + + + Sbjct: 256 YVRKGDARLPLKWMAPETIFDRVY-TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 314 Query: 244 IFKA--EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 K P + + + + P+ R TF+E++E+ Sbjct: 315 RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 77.7 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 44/123 (35%), Gaps = 10/123 (8%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFA----RNVE-NGDNVAIKVI 62 P +S R + +LG+ LG G F +V A + VA+K++ Sbjct: 9 PLDEHCERLPYDASKWEFPR-DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML 67 Query: 63 DKEKVLKNKMIAQIKREISTM-KLIKHPNVIRMFEVMA-SKTKIYFVLEFVTGGELFDKI 120 + + + E+ + + H NV+ + + ++EF G L + Sbjct: 68 K--EGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL 125 Query: 121 SSN 123 S Sbjct: 126 RSK 128 >5VDK-A nrPDB Length = 297 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 107/298 (35%), Gaps = 43/298 (14%) Query: 19 GSSSGGRTRVGKYEL----GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 G G +YE +G G F V +G AIK + + Sbjct: 1 GPEFGSTNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNEN 59 Query: 75 QIKREISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN----GRLKED 129 E+ ++ HP+V+R + A + E+ GG L IS N +E Sbjct: 60 SALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEP 119 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENL-----------------------LLDANG 166 + + Q+ ++Y H+ + H D+KP N+ L AN Sbjct: 120 KLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANV 179 Query: 167 ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLM 226 K+ D G + + + + G ++A E++ KAD+++ G+ + V Sbjct: 180 MYKIGDLGHATSINKPKVEE------GDSRFLANEILQEDYRHLPKADIFALGLTIAV-A 232 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFT-CPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 AG + + I K F P S S L+K ++ P+ R + A + N Sbjct: 233 AGAESLP--TNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARN 288 >4IAN-A nrPDB Length = 358 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 67/336 (19%), Positives = 124/336 (36%), Gaps = 81/336 (24%) Query: 24 GRTRVGKYELGRTLGEGTFAKVKFARNVEN-GDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G +Y + G+G F+ V AR+ VA+K+I ++++ + +E+ Sbjct: 25 GEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGL----KELEF 80 Query: 83 MKLIKHP------NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR---LKEDEARK 133 +K + + +R+F K + V E ++ L + + G+ L R Sbjct: 81 LKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRS 139 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL-KVSDFGLSALPQQVREDGLLHTTC 192 Y QQL A+ + H D+KP+N+L++ + + K+ DFG ++ D + Sbjct: 140 YSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHV----ADNDITPYL 195 Query: 193 GTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP 252 + Y APE+I K YD D+WS G L+ L G + F + K + P Sbjct: 196 VSRFYRAPEIIIGKSYDYG-IDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMP 254 Query: 253 -----------PWFSASA-------------------------KKL-------------- 262 F + K L Sbjct: 255 NKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQ 314 Query: 263 ------IKRILDP----NPATRITFAEVIENEWFKK 288 +K +LD +PA RI+ + +++ + ++ Sbjct: 315 RKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3QD2-B nrPDB Length = 332 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 122/330 (36%), Gaps = 78/330 (23%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVID-------KEKVLKN------------ 70 +E + +G G F V A+N + N AIK I +EKV++ Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 71 ---------KMIAQIKRE---------------------------ISTMKLIKHPNVIRM 94 + + E I M N + Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDE---ARKYFQQLINAVDYCHSRGVY 151 + + K +Y ++ L D ++ L++ E F Q+ AV++ HS+G+ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 152 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL----------HTTCGTPNYVAPE 201 HRDLKP N+ + +KV DFGL Q E+ + GT Y++PE Sbjct: 187 HRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE 246 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAE-FTCPPWFS---A 257 I+ Y K D++S G+ILF L+ + S + I P F+ Sbjct: 247 QIHGNNY-SHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQKYP 300 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFK 287 +++ +L P+P R ++IEN F+ Sbjct: 301 QEHMMVQDMLSPSPTERPEATDIIENAIFE 330 >3LLT-A nrPDB Length = 360 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 125/335 (37%), Gaps = 89/335 (26%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 90 + + R +G+GTF +V ++++N A+KV+ K K K E +K I++ + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIK----KYTRSAKIEADILKKIQNDD 92 Query: 91 V-----IRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVD 143 + ++ + + E + G L++ I+ N ++ + Y +++ A++ Sbjct: 93 INNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALN 151 Query: 144 YCHSRGVYHRDLKPENLLLDA-------------------------NGALKVSDFGLSAL 178 Y + H DLKPEN+LLD + +K+ DFG + Sbjct: 152 YLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF 211 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF---EDS 235 + T Y APEVI N G+D +D+WS G +L L G L F E Sbjct: 212 KSDYHG-----SIINTRQYRAPEVILNLGWD-VSSDMWSFGCVLAELYTGSLLFRTHEHM 265 Query: 236 NLTSLYKKIFKA-----------------------EFTCPPWFS---------------- 256 ++ + I + + P S Sbjct: 266 EHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYK 325 Query: 257 ----ASAKKLIKRILDPNPATRITFAEVIENEWFK 287 + IL +P R + AE++++++ + Sbjct: 326 IIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >6BFN-A nrPDB Length = 342 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 51/208 (24%), Positives = 79/208 (37%), Gaps = 17/208 (8%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKHPNVIRM 94 +GEG F V A A+K + + L+ + Q E+ + +HPN++ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 95 FEVMASKTKIYFVLEFVTGGELFDKIS----SNGRLKEDEARKYFQQLINAVDYCH--SR 148 A V F+ G L D++ + L + A+ + H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 149 GVYHRDLKPENLLLDANGALKVSDFGLSAL-------PQQVREDGLLHTTCGTPNYVAPE 201 + H D+K N+LLD K+ DFGL+ P Q T GT Y+ E Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 206 Query: 202 VINNKGYDGAKADLWSCGVILFVLMAGY 229 I G D +S GV++ +AG Sbjct: 207 YIKT-GRLAVDTDTFSFGVVVLETLAGQ 233 >2CMW-A nrPDB Length = 310 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 120/317 (37%), Gaps = 41/317 (12%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH--P 89 +G+ +G G F +++ +N+ + VAIK+ + Q+ E K + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKS-----RAPQLHLEYRFYKQLGSAGE 57 Query: 90 NVIRMFEVMASKTKIYFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 + +++ VLE + + +LFD QL++ ++Y HS Sbjct: 58 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLLSRMEYVHS 115 Query: 148 RGVYHRDLKPENLLLDANG-----ALKVSDFGLSALPQQVREDGLL-----HTTCGTPNY 197 + + +RD+KPEN L+ G + + DFGL+ + + GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCPPW 254 ++ K + DL + G + + G LP++ L Y+KI + P Sbjct: 176 MSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTP-- 232 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGE 314 I+ + + P T+ + F ++ P +E D+ F+ G Sbjct: 233 --------IEALCENFPEEMATYLRYVRRLDF---FEKPDYEYLRTLFTDL---FEKKGY 278 Query: 315 SKNLVVERREEGLKTPV 331 + + + + TPV Sbjct: 279 TFDYAYDWVGRPIPTPV 295 >2CHL-A nrPDB Length = 351 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 124/327 (37%), Gaps = 42/327 (12%) Query: 22 SGGRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 S G VG + +G+ +G G F +++ +N+ + VAIK+ + Q+ E Sbjct: 22 SMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKS-----RAPQLHLEY 76 Query: 81 STMKLIKH-PNVIRMFEVMASKTKIYFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQ 137 K + + +++ VLE + + +LFD Q Sbjct: 77 RFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQ 134 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLDANG-----ALKVSDFGLSALPQQVREDGLL---- 188 LI+ ++Y HS+ + +RD+KPEN L+ G + + DF L+ + Sbjct: 135 LISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYRE 194 Query: 189 -HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKI 244 + GT Y++ K + DL + G + + G LP++ L Y+KI Sbjct: 195 HKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 253 Query: 245 FKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDD 304 + P I+ + + P V ++F+K P ++ D Sbjct: 254 GDTKRATP----------IEVLCENFPEMATYLRYVRRLDFFEK----PDYDYLRKLFTD 299 Query: 305 VDAIFDDSGESKNLVVERREEGLKTPV 331 + FD G + + + L TPV Sbjct: 300 L---FDRKGYMFDYEYDWIGKQLPTPV 323 >3HNG-A nrPDB Length = 360 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 40/163 (24%), Positives = 74/163 (45%), Gaps = 4/163 (2%) Query: 123 NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQV 182 + ++ Y Q+ +++ SR HRDL N+LL N +K+ DFGL+ + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 183 REDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLY 241 + T ++APE I +K Y K+D+WS GV+L+ + + G P+ + + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 242 KKIFKA--EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIE 282 + P + + +++ +P R FAE++E Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 Score = 81.1 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 47/126 (37%), Gaps = 10/126 (7%) Query: 8 SRSTPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFA-----RNVENGDNVAIKVI 62 P +S R + +LG++LG G F KV A + VA+K++ Sbjct: 7 PLDEQCERLPYDASKWEFAR-ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKML 65 Query: 63 DKEKVLKNKMIAQIKREISTMKLI-KHPNVIRMFEVMASK-TKIYFVLEFVTGGELFDKI 120 + + E+ + I H NV+ + + + ++E+ G L + + Sbjct: 66 KEGATASE--YKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYL 123 Query: 121 SSNGRL 126 S L Sbjct: 124 KSKRDL 129 >4LFI-A nrPDB Length = 374 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 122/338 (36%), Gaps = 82/338 (24%) Query: 26 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAI------------------------KV 61 T YE+ +G G +++V +++ + I KV Sbjct: 37 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 96 Query: 62 IDKEKVLKNKMIAQIKREISTMKLIK----------HPNVIRMFEVMASK--TKIYFVLE 109 + ++E +K I+ H N+I +F+++ V E Sbjct: 97 PPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 155 Query: 110 FVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA-NGAL 168 +V D +L + E R Y +L+ A+DYCHS G+ HRD+KP N+++D N L Sbjct: 156 YVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 212 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 228 ++ D+GL+ E + + + PE++ + DLWS G +L ++ Sbjct: 213 RLIDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 269 Query: 229 YLP-FEDSNLTSLYKKI-------------FKAEFTCPPWF------------------- 255 P F ++ T KI K E T P F Sbjct: 270 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 329 Query: 256 -----SASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 + LI +L + R+T E + + WF Sbjct: 330 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 367 >2C47-A nrPDB Length = 313 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 67/329 (20%), Positives = 125/329 (37%), Gaps = 40/329 (12%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HP 89 + +G+ +G G F +++ +N+ + VAIK+ + Q+ E K + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKS-----RAPQLHLEYRFYKQLSATE 60 Query: 90 NVIRMFEVMASKTKIYFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 V +++ VLE + + +LFD QLI ++Y H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLITRMEYVHT 118 Query: 148 RGVYHRDLKPENLLLDANGA-----LKVSDFGLSALPQQVREDGLL-----HTTCGTPNY 197 + + +RD+KPEN L+ G + + DFGL+ + + GT Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCPPW 254 ++ K + DL + G + + G LP++ L Y+KI + P Sbjct: 179 MSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP-- 235 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGE 314 I+ + + P T+ + F ++ P ++ D+ FD SG Sbjct: 236 --------IEVLCENFPEEMATYLRYVRRLDF---FEKPDYDYLRKLFTDL---FDRSGF 281 Query: 315 SKNLVVERREEGLKTPVTMNAFELISTSQ 343 + + + L TP+ +L S Q Sbjct: 282 VFDYEYDWAGKPLPTPIGTVHTDLPSQPQ 310 >4WUA-A nrPDB Length = 401 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 78/398 (19%), Positives = 131/398 (32%), Gaps = 128/398 (32%) Query: 9 RSTPSRSTPSGSSSGGRTRV-------GKYELGRTLGEGTFAKVKFARNVENGDNVAIKV 61 + P+ GG V G+Y + R LG G F+ V + +++ VA+KV Sbjct: 14 SDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKV 73 Query: 62 IDKEKVLKNKMIAQIKREISTMKLIKH--PN------VIRMFEVMA----SKTKIYFVLE 109 + + + EI +K +++ PN V+++ + + T I V E Sbjct: 74 VKSAEHYTETALD----EIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFE 129 Query: 110 FVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANGA 167 + L I SN L +K QQ++ +DY H++ + H D+KPEN+LL N Sbjct: 130 VLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQ 189 Query: 168 -------------------------------------------------LKVSDFGLSAL 178 +K++D G + Sbjct: 190 YIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACW 249 Query: 179 PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFE----- 233 + T Y + EV+ GY+ AD+WS + F L G FE Sbjct: 250 VHK-----HFTEDIQTRQYRSLEVLIGSGYNTP-ADIWSTACMAFELATGDYLFEPHSGE 303 Query: 234 ----DSNLTSLY---------KKIFKAEFT---------------CPPW----------- 254 D + +L K I +++ PW Sbjct: 304 EYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYE 363 Query: 255 FSAS----AKKLIKRILDPNPATRITFAEVIENEWFKK 288 +S + +L+ P R T AE + + W Sbjct: 364 WSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 401 >3G2F-A nrPDB Length = 336 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 117/345 (33%), Gaps = 57/345 (16%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK--L 85 + +L +G G + V + VA+KV E + + L Sbjct: 12 LDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFAN------RQNFINEKNIYRVPL 63 Query: 86 IKHPNVIRMF----EVMASKT-KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLIN 140 ++H N+ R V A + V+E+ G L +S + + + + Sbjct: 64 MEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTR 122 Query: 141 AVDYCH---------SRGVYHRDLKPENLLLDANGALKVSDFGLS------ALPQQVRED 185 + Y H + HRDL N+L+ +G +SDFGLS L + ED Sbjct: 123 GLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 186 GLLHTTCGTPNYVAPEVINNKGYDG------AKADLWSCGVILFVLMAGYL-PFEDSNLT 238 + GT Y+APEV+ + D+++ G+I + + F ++ Sbjct: 183 NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVP 242 Query: 239 SLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENA 298 Y+ F+ E P F + L+ R R F E W + A Sbjct: 243 E-YQMAFQTEVGNHPTF-EDMQVLVSR-----EKQRPKFPEA----W-------KENSLA 284 Query: 299 DVSLDDVDAIFDDSGESKNLVVERREEGLKTPVTMNAFELISTSQ 343 SL + D L + EE + + M S S Sbjct: 285 VRSLKETIEDCWDQDAEARLTAQCAEERM-AELMMIWERNKSVSP 328 >5X18-A nrPDB Length = 295 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 132/317 (41%), Gaps = 39/317 (12%) Query: 24 GRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 82 G T VG Y++G+ +GEG+F + N+ NG VAIK ++ Q++ E T Sbjct: 1 GSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRK-----TEAPQLRDEYKT 55 Query: 83 MKLIKH-PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQLIN 140 K++ PN+ + V++ + G L D GR + Q+I Sbjct: 56 YKILNGTPNIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMIT 114 Query: 141 AVDYCHSRGVYHRDLKPENLLLDANGA-----LKVSDFGLSALPQQVR-----EDGLLHT 190 ++ H+ + +RD+KP+N L+ G + + DFG++ + + + Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKS 174 Query: 191 TCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKA 247 GT Y++ + + D+ + G + F + G+LP++ N Y+KI + Sbjct: 175 LSGTARYMSINTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDA 307 + S + L + + P + E++ + F++ P +E L + Sbjct: 234 KR------STNVYDLAQGL----PVQFGRYLEIVRSLSFEE---CPDYEGYRKLL---LS 277 Query: 308 IFDDSGESKNLVVERRE 324 + DD GE+ + + + Sbjct: 278 VLDDLGETADGQYDWMK 294 >2X7G-A nrPDB Length = 389 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 68/396 (17%), Positives = 123/396 (31%), Gaps = 126/396 (31%) Query: 9 RSTPSRSTPSGSSSGGRTRV-------GKYELGRTLGEGTFAKVKFARNVENGDNVAIKV 61 + P+ GG V G+Y + R LG G F+ V +++ VA+KV Sbjct: 4 SDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKV 63 Query: 62 IDKEKVLKNKMIAQIKREISTMKLIK-----HPN---VIRMFEVMA----SKTKIYFVLE 109 + + + EI +K ++ PN V+++ + + + V E Sbjct: 64 VKSAQHYTETALD----EIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE 119 Query: 110 FVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHSR-GVYHRDLKPENLLLDANG- 166 + L I SN L + +Q++ +DY HS+ + H D+KPEN+L+ + Sbjct: 120 VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDA 179 Query: 167 ----------------------------------------------ALKVSDFGLSALPQ 180 +K++D G + Sbjct: 180 YVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH 239 Query: 181 QVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED------ 234 + T Y + EV+ GY AD+WS + F L G FE Sbjct: 240 K-----HFTEDIQTRQYRSIEVLIGAGY-STPADIWSTACMAFELATGDYLFEPHSGEDY 293 Query: 235 -------SNLTSLYKKIFK-----------------------------------AEFTCP 252 +++ L I + ++ P Sbjct: 294 SRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWP 353 Query: 253 PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 +A + +L+ P R + E + + W Sbjct: 354 HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >4NFN-A nrPDB Length = 309 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 121/314 (38%), Gaps = 37/314 (11%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++++ + +G G F ++ A ++ +NVA+KV E + K + +K E++ +K ++ Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQG 75 Query: 89 P-NVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVDYC 145 +V R ++ Y V++ G L D S G + +Q++ +++ Sbjct: 76 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 134 Query: 146 HSRGVYHRDLKPENL----LLDANGALKVSDFGLSA----LPQQVREDGLLHTTCGTPNY 197 HS G HRD+KP N L + DFGL+ VR + GT Y Sbjct: 135 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 194 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 + N+ G DLWS +L G LP+ I + Sbjct: 195 ASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK---------Y 244 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKN 317 + L+K + P+ F +++ + P ++ ++ + G ++N Sbjct: 245 EHRMLLKHM----PSE---FHLFLDHIASLDYFTKPDYQLIMSVFENS---MKERGIAEN 294 Query: 318 LVVERREEGLKTPV 331 + + G + Sbjct: 295 EAFDWEKAGTDALL 308 >3SV0-A nrPDB Length = 483 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 58/242 (23%), Positives = 103/242 (42%), Gaps = 29/242 (11%) Query: 25 RTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM 83 RVG K+ LGR +G G+F ++ N++ + VAIK+ + + Q+ E Sbjct: 2 EPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVK-----TKHPQLLYESKIY 56 Query: 84 KLIKH----PNVIRMFEVMASKTKIYFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQ 137 ++++ PN +R F V V++ + + +LF+ S +L Q Sbjct: 57 RILQGGTGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQ 111 Query: 138 LINAVDYCHSRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLL-----H 189 +IN V++ HS+ HRD+KP+N L+ + + DFGL+ + + Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 190 TTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS---NLTSLYKKIFK 246 GT Y + + DL S G +L + G LP++ Y+KI + Sbjct: 172 NLTGTARYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 Query: 247 AE 248 + Sbjct: 231 KK 232 >5FQD-C nrPDB Length = 341 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 31/254 (12%) Query: 19 GSSSGGRTRV---GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ 75 SSSG + GKY+L R +G G+F + A N+ NG+ VA+K+ + Q Sbjct: 6 ASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKL-----ESQKARHPQ 60 Query: 76 IKREISTMKLIKH----PNVIRMFEVMASKTKIYFVLEFV--TGGELFDKISSNGRLKED 129 + E K+++ P++ R + K V++ + + +LF+ S R Sbjct: 61 LLYESKLYKILQGGVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMK 115 Query: 130 EARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA---LKVSDFGLSALPQQVREDG 186 Q+I+ ++Y H++ HRD+KP+N L+ L + DFGL+ + R Sbjct: 116 TVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQ 175 Query: 187 LL-----HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLT 238 + GT Y + + D+ S G +L LP++ + Sbjct: 176 HIPYREDKNLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKK 234 Query: 239 SLYKKIFKAEFTCP 252 Y+KI + + + P Sbjct: 235 QKYEKISEKKMSTP 248 >4L00-A nrPDB Length = 304 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 104/283 (36%), Gaps = 23/283 (8%) Query: 17 PSGSSSGGRTRVGKYELGRTLGEGTFAKVKFAR------NVENGDNVAIKVIDKEKVLKN 70 P S R G LG GT + + + IKVI K + Sbjct: 13 PMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSH 72 Query: 71 KMIA-QIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNG-RLKE 128 + I+ S M+ + H +++ ++ V + V EFV GG L + L Sbjct: 73 RDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTT 132 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA-------LKVSDFGLSALPQQ 181 K +QL +A+ Y + + H ++ +NLLL G +K+SD G+ Sbjct: 133 PWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLS 192 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSL 240 +E ++APE + + AD WS G L+ + G +P +D L Sbjct: 193 RQE------CIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEK 246 Query: 241 YKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 + P L+ R ++ +P R F ++ + Sbjct: 247 ERFYESRCRPVTPSC-KELADLMTRCMNYDPNQRPFFRAIMRD 288 >5USZ-A nrPDB Length = 289 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 101/276 (36%), Gaps = 27/276 (9%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNVENGD-------NVAIKVIDKEKVLKNKMIAQIK 77 + R +LG+GTF K+ E GD V +KV+DK Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK---AHRNYSESFF 60 Query: 78 REISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQ 136 S M + H +++ + V + V EFV G L + N + + + Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK 120 Query: 137 QLINAVDYCHSRGVYHRDLKPENLLL--------DANGALKVSDFGLSALPQQVREDGLL 188 QL A+ + + H ++ +N+LL +K+SD G+S V +L Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT---VLPKDIL 177 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA 247 +V PE I N D WS G L+ + + G P + + ++ Sbjct: 178 QER---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQF-YED 233 Query: 248 EFTCPPWFSASAKKLIKRILDPNPATRITFAEVIEN 283 P +A LI +D P R +F +I + Sbjct: 234 RHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRD 269 >4BTK-A nrPDB Length = 337 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 61/307 (19%), Positives = 119/307 (38%), Gaps = 37/307 (12%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 ++++ + +G G F ++ A ++ +NVA+KV E + K + +K E++ +K ++ Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQV--LKMEVAVLKKLQG 110 Query: 89 P-NVIRMFEVMASKTKIYFVLEFVTGGELFDKISS--NGRLKEDEARKYFQQLINAVDYC 145 +V R ++ Y V++ G L D S G + +Q++ +++ Sbjct: 111 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 169 Query: 146 HSRGVYHRDLKPENL----LLDANGALKVSDFGLSA----LPQQVREDGLLHTTCGTPNY 197 HS G HRD+KP N L + DFGL+ VR + GT Y Sbjct: 170 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSA 257 + N+ G DLWS +L G LP+ I + Sbjct: 230 ASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK---------Y 279 Query: 258 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKN 317 + L+K + P+ F +++ + P ++ ++ + G ++N Sbjct: 280 EHRMLLKHM----PSE---FHLFLDHIASLDYFTKPDYQLIMSVFENS---MKERGIAEN 329 Query: 318 LVVERRE 324 + + Sbjct: 330 EAFDWEK 336 >4F9B-A nrPDB Length = 361 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 114/344 (33%), Gaps = 94/344 (27%) Query: 31 YELGRTLGEGTFAKVKFARN---VENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 87 +++ +GEGTF+ V A V + +A+K + +I E+ + + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-----IRIAAELQCLTVAG 77 Query: 88 H-PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 NV+ + + + ++ D ++S L E R+Y L A+ H Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIH 134 Query: 147 SRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVR---------------------- 183 G+ HRD+KP N L + + DFGL+ + Sbjct: 135 QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCS 194 Query: 184 ----EDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPF----EDS 235 + GTP + APEV+ D+WS GVI L++G PF +D Sbjct: 195 ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDL 254 Query: 236 NLTSLYKKIFKAEFTCPP--------WFSASA-----KKLIKRI---------------- 266 + I + T S +KL +R+ Sbjct: 255 TALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQG 314 Query: 267 -------LD---------------PNPATRITFAEVIENEWFKK 288 + NPA+RIT E + + +FK Sbjct: 315 HATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >5X1R-A nrPDB Length = 302 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 104/295 (35%), Gaps = 34/295 (11%) Query: 13 SRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM 72 S S PSG R ++E+ +GEG F V A + + +AIK + K Sbjct: 11 SNSLPSGY------RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRND 64 Query: 73 ------------------IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGG 114 + +E + HP ++ + Y +F +G Sbjct: 65 DLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGT 124 Query: 115 ELFDK-ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDF 173 L + ++ E R+ L +A++ H G HRD+ +N+ + + + DF Sbjct: 125 TLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDF 184 Query: 174 GLSALPQQVREDGLLHTTCGTPNYVAPEVI--NNKGYDGAKADLWSCGVILFVLMAGYLP 231 G + D P + E N+ G G D+++ G +L L+ G P Sbjct: 185 GSARKEIGNLSDE--TEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 Query: 232 FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI----TFAEVIE 282 S + S+ P +S + + R L P R AE++E Sbjct: 243 -PVSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >4TN6-A nrPDB Length = 318 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 118/309 (38%), Gaps = 38/309 (12%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 88 +Y LGR +G G+F + ++ G+ VAIK+ + +K K Q+ E K+++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKH-PQLHIESKIYKMMQG 61 Query: 89 PNVIRMFEVM-ASKTKIYFVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 145 I A V+E + + +LF+ S + Q+I+ ++Y Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYI 119 Query: 146 HSRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLL-----HTTCGTPNY 197 HS+ HRD+KP+N L+ + + DFGL+ + R + GT Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCPPW 254 + + DL S G +L G LP++ + Y++I + + + P Sbjct: 180 ASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP-- 236 Query: 255 FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGE 314 I+ + P+ FA + + P + ++ F G Sbjct: 237 --------IEVLCKGYPSE---FATYLNFCRSLRFDDKPDYSYLRQLFRNL---FHRQGF 282 Query: 315 SKNLVVERR 323 S + V + Sbjct: 283 SYDYVFDWN 291 >4RT7-A nrPDB Length = 415 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 36/210 (17%), Positives = 85/210 (40%), Gaps = 18/210 (8%) Query: 78 REISTMKLIKHPN---VIRMFE-VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARK 133 RE+ HP+ + + S+ +I E+ + ++ L ++ Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLC 247 Query: 134 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 193 + Q+ +++ + HRDL N+L+ +K+ DFGL+ + Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 194 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA--EFT 250 ++APE + G K+D+WS G++L+ + + G P+ + + + K+ + + Sbjct: 308 PVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMD 366 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEV 280 P + + +++ + R +F + Sbjct: 367 QPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 95.4 bits (236), Expect = 6e-20, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 42/105 (40%), Gaps = 8/105 (7%) Query: 25 RTRVGKYELGRTLGEGTFAKVKFARNV---ENGD--NVAIKVIDKEKVLKNKMIAQIKRE 79 E G+ LG G F KV A + G VA+K++ ++ + + E Sbjct: 61 EFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSE 118 Query: 80 ISTMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSN 123 + M + H N++ + IY + E+ G+L + + S Sbjct: 119 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 >5M07-A nrPDB Length = 276 Score = 148 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 115/286 (40%), Gaps = 47/286 (16%) Query: 16 TPSGSS---SGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKM 72 P GS + G T G Y + R LG +V ++ A+KV+ ++ Sbjct: 15 VPRGSHMALASGVTFAG-YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEF 73 Query: 73 IAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDE 130 + +RE + HP+++ + + +++ +++V G + ++ L E Sbjct: 74 RRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGE 133 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA----NGALKVSDFGLSALPQQVREDG 186 + A+DY H RG+ HRD+ P N++L + + + ++DFG+++ Sbjct: 134 VLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------- 185 Query: 187 LLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK 246 P+Y APE+ DG +AD ++ + L AG P + S+ L Sbjct: 186 --------PSYPAPELSAGADVDG-RADQYALALTAIHLFAGAPPVDRSHTGPL------ 230 Query: 247 AEFTCPPWFSASAKKL------IKRILDPNPATRIT----FAEVIE 282 PP SA L + R L PA R FA+ + Sbjct: 231 ----QPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFADAMN 272 >5J0A-A nrPDB Length = 300 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 102/285 (35%), Gaps = 37/285 (12%) Query: 33 LGRTLGEGTFAKVKFARNVENG---DNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIK 87 + LG GT V + G A+K I+ ++ ++ E +K + Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 88 HPNVIRMFEVMA-SKTKIYFVLEFVTGGELFDKISSNGR-----LKEDEARKYFQQLINA 141 HPN++ + + +E+ L D I + K + Sbjct: 73 HPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARG 132 Query: 142 VDYCHS-RGVYHRDLKPENLLLDANG-ALKVSDFGLSALPQQVRE-DGLLHTTCGTPNYV 198 + Y H + + H D+K N+++ + +K+ D G+S + E GT + Sbjct: 133 LKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLP--------------FEDSNLTSLYKKI 244 E + G KAD+++ G+ L+ +M +P F++S+ + Sbjct: 193 PKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDD--EAY 250 Query: 245 FKAEFTCPPWFSAS-------AKKLIKRILDPNPATRITFAEVIE 282 + A T PP +L + +P R + A ++E Sbjct: 251 YAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >1CSN-A nrPDB Length = 298 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 101/264 (38%), Gaps = 28/264 (10%) Query: 22 SGGRTRVG-KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREI 80 SG VG Y++GR +GEG+F + N+ N VAIK + Q++ E Sbjct: 2 SGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRS-----DAPQLRDEY 56 Query: 81 STMKLI-KHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR-LKEDEARKYFQQL 138 T KL+ + ++ V++ + G L D + GR +Q+ Sbjct: 57 RTYKLLAGCTGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQM 115 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGA-----LKVSDFGLSALPQQVR-----EDGLL 188 + V H + + +RD+KP+N L+ + + V DFG+ + Sbjct: 116 LARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREK 175 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIF 245 GT Y++ + + DL + G + + G LP++ + Y++I Sbjct: 176 KNLSGTARYMSINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIG 234 Query: 246 KAEFTCP-----PWFSASAKKLIK 264 + + + P F K + Sbjct: 235 EKKQSTPLRELCAGFPEEFYKYMH 258 >2PZI-A nrPDB Length = 681 Score = 141 bits (355), Expect = 8e-34, Method: Composition-based stats. Identities = 67/274 (24%), Positives = 112/274 (40%), Gaps = 45/274 (16%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVE-NGDNVAIKVIDKEKVLKNKMIAQIKREI 80 + G G+YE+ + G + A + NG V +K + + + +A +R Sbjct: 73 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-- 130 Query: 81 STMKLIKHPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 + + HP+++++F + + Y V+E+V G L K S +L EA Y Sbjct: 131 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYL 188 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 +++ A+ Y HS G+ + DLKPEN++L LK+ D G V GTP Sbjct: 189 LEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLG------AVSRINSFGYLYGTP 241 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL----------PFEDSNLTSLYKKIF 245 + APE++ D+++ G L L P ED + Y Sbjct: 242 GFQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRYVDGLP-EDDPVLKTYDSYG 298 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 + L++R +DP+P R T AE Sbjct: 299 R---------------LLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 67/274 (24%), Positives = 112/274 (40%), Gaps = 45/274 (16%) Query: 22 SGGRTRVGKYELGRTLGEGTFAKVKFARNVE-NGDNVAIKVIDKEKVLKNKMIAQIKREI 80 + G G+YE+ + G + A + NG V +K + + + +A +R Sbjct: 112 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-- 169 Query: 81 STMKLIKHPNVIRMFEVMASKTKI-----YFVLEFVTGGELFDKISSNGRLKEDEARKYF 135 + + HP+++++F + + Y V+E+V G L K S +L EA Y Sbjct: 170 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYL 227 Query: 136 QQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 +++ A+ Y HS G+ + DLKPEN++L LK+ D G V GTP Sbjct: 228 LEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLG------AVSRINSFGYLYGTP 280 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL----------PFEDSNLTSLYKKIF 245 + APE++ D+++ G L L P ED + Y Sbjct: 281 GFQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRYVDGLP-EDDPVLKTYDSYG 337 Query: 246 KAEFTCPPWFSASAKKLIKRILDPNPATRITFAE 279 + L++R +DP+P R T AE Sbjct: 338 R---------------LLRRAIDPDPRQRFTTAE 356 >4XHH-A nrPDB Length = 403 Score = 137 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 108/308 (35%), Gaps = 38/308 (12%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 K+ +GR +G G+F + N+ +G+ VAI E + Q+ E K + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRH--PQLDYESRVYKYLSGG 62 Query: 90 NVIRMFEVMASKTKIY-FVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 I + + V++ + + +LF+ K Q+I V Y H Sbjct: 63 VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFK--TVIMLALQMICRVQYIH 120 Query: 147 SRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLL-----HTTCGTPNYV 198 R HRD+KP+N L+ + V DFGLS + + + GT Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCPPWF 255 + + DL S G +L G LP++ + Y +I + + Sbjct: 181 SVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI---- 235 Query: 256 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGES 315 S + L + P + F+E + K + P + D+ + Sbjct: 236 --SVETLCAGL----P---LEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLE---YH 283 Query: 316 KNLVVERR 323 + + + Sbjct: 284 NDHLFDWT 291 >4JRN-A nrPDB Length = 372 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 103/289 (35%), Gaps = 48/289 (16%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-------- 87 LG G FA V A +VE + +A+KV EK ++ + ++RE S + Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 88 --------HPNVIRM----------FEVMASKTKIYFVLEFVTGGELFDKIS-------- 121 +V+ + + YF+L ++ IS Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 122 SNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQ 181 + Q I V ++G+ H D+KP N LL +G L + DFG Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG------T 248 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKG--YDGAKADLWSCGVILFVLMAGYLPFEDSNLTS 239 R + + GTP Y PE D W G+ L+ + P + Sbjct: 249 YRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---TPADG 305 Query: 240 LYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKK 288 ++ + F P + LI+ +L+ +P R+ + +E FK+ Sbjct: 306 IWDYL---HFADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKE 351 >4XHL-A nrPDB Length = 394 Score = 135 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 87/235 (37%), Gaps = 22/235 (9%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 K+ +GR +G G+F + N+ +G+ VAI E + Q+ E + + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRH--PQLDYESRVYRYLSGG 62 Query: 90 NVIRMFEVMASKTKIY-FVLEFV--TGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 I + + V++ + + +LF+ K Q+ + Y H Sbjct: 63 VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFK--TVIMLALQMFCRIQYIH 120 Query: 147 SRGVYHRDLKPENLLLD---ANGALKVSDFGLSALPQQVREDGLL-----HTTCGTPNYV 198 R HRD+KP+N L+ + V DFGLS + + + GT Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 199 APEVINNKGYDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFT 250 + + DL S G +L G LP++ + Y +I + + Sbjct: 181 SVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLN 234 >5C01-A nrPDB Length = 342 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 87/248 (35%), Gaps = 24/248 (9%) Query: 48 ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFV 107 R+ V +KV+D + S M + H ++ + V + V Sbjct: 101 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 108 LEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL---- 162 E+V G L + G + QQL +A+ Y ++ + H ++ N+LL Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217 Query: 163 ---DANGALKVSDF--GLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD-GAKADLW 216 + +K+SD GL AL ++ R + ++APE + D W Sbjct: 218 LAEGTSPFIKLSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKW 269 Query: 217 SCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 G L + G P + + + + P A L + L P R Sbjct: 270 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRP 328 Query: 276 TFAEVIEN 283 +F ++ + Sbjct: 329 SFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 87/248 (35%), Gaps = 24/248 (9%) Query: 48 ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFV 107 R+ V +KV+D + S M + H ++ + V + V Sbjct: 78 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 134 Query: 108 LEFVTGGELFDKISS-NGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL---- 162 E+V G L + G + QQL +A+ Y ++ + H ++ N+LL Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 194 Query: 163 ---DANGALKVSDF--GLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD-GAKADLW 216 + +K+SD GL AL ++ R + ++APE + D W Sbjct: 195 LAEGTSPFIKLSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKW 246 Query: 217 SCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 G L + G P + + + + P A L + L P R Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-LTSQCLTYEPTQRP 305 Query: 276 TFAEVIEN 283 +F ++ + Sbjct: 306 SFRTILRD 313 >2ZFD-B nrPDB Length = 123 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 6/98 (6%) Query: 332 TMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDV-KT 390 MNAF++IS S G NL LF R RF S +A +V ++E + V K Sbjct: 5 RMNAFDIISGSPGFNLSGLFGDARKY-DRVERFVSAWTAERVVERLEEIVSAENLTVAKK 63 Query: 391 NNYKMKLTGEKSGRKGQLAVATEVFQVAPSLYMVEMRK 428 + MK+ G+ KG A+ E+ Q+ L M+E+RK Sbjct: 64 ETWGMKIEGQ----KGNFAMVVEINQLTDELVMIEVRK 97 >6EQI-C nrPDB Length = 433 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 68/352 (19%), Positives = 127/352 (36%), Gaps = 80/352 (22%) Query: 21 SSGGRTRVGKYELGRTLGEGTFAKVKFAR--NVENGD---NVAIKVIDKEKVLKNK--MI 73 + + +LG + +G A V A+ NV++ +A+K++ V N ++ Sbjct: 7 EQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAIL 66 Query: 74 AQIKRE---------------ISTMKLIK-----HPNVIRMFEVMASKTK---------- 103 + RE I + K HPN++RM+ V A + Sbjct: 67 KAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYP 126 Query: 104 -----------------IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 146 ++ V++ L + + + QL+ AV + + Sbjct: 127 EALPPRINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMN 184 Query: 147 SRGVYHRDLKPENLLLDAN-----GALKVSDFGLSALPQQ----VREDGLLHTTCGTPNY 197 + HRDLK +N+L+D + + ++DFG +Q + G Sbjct: 185 IHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRAL 244 Query: 198 VAPEVINNKG-----YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFT-C 251 +APE+ N K + K+DLW+ G I + + PF D + L K + + Sbjct: 245 MAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPEL 304 Query: 252 PPWFSASAKKLIKRILDPNPATRI------TFAEV---IENEWFKKGYKAPK 294 P + L+ +L + R+ T A++ + W K+ Y P Sbjct: 305 PDTIPFIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSSWLKENYTLPN 356 >5OAT-A nrPDB Length = 411 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 65/333 (19%), Positives = 117/333 (35%), Gaps = 70/333 (21%) Query: 28 VGKYELGRTLGEGTFAKVKFARNVENGDN-----VAIKVIDKEKVLKN--KMIAQIKRE- 79 + LG+ + +GT V A+ ++ + A+K++ + +N +++ + RE Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 80 ----------------ISTMKLIKH----PNVIRMFEVMAS-----------------KT 102 I KH PN++ +F V Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 103 KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL 162 ++ +++ L +S+ + QL+ V + + G+ HRDLK +NLLL Sbjct: 130 SLFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLL 186 Query: 163 D----ANGALKVSDFGLSALPQ----QVREDGLLHTTCGTPNYVAPEVINNKG-----YD 209 D + L +SDFG + + G +APE+I K + Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLN 246 Query: 210 GAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDP 269 +KADLW+ G I + + + PF + + P + L+ +L Sbjct: 247 YSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLLKR 306 Query: 270 NPATRITFAEVIE---------NEWFKKGYKAP 293 NP R+ + W K G K P Sbjct: 307 NPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVP 339 >4L68-A nrPDB Length = 340 Score = 116 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 80/192 (41%), Gaps = 12/192 (6%) Query: 43 AKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKT 102 A + +G +A+K + K+ + + + E++ + ++H N+ + + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGERE----FRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 103 KIYFVLEFVTGGELFDKISSN-GRLKEDEARKYFQQLINAVDYCHS---RGVYHRDLKPE 158 + + V ++++ G L + SN G L + + + H + H+++ Sbjct: 109 EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 159 NLLLDANGALKVSDFGLSAL--PQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 216 +L+D + ++ D GL+ L P E + G YVAPE + K D++ Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVY 227 Query: 217 SCGVILFVLMAG 228 GV+L L G Sbjct: 228 GLGVVLLELATG 239 >6J6I-B nrPDB Length = 351 Score = 116 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 41/186 (22%), Positives = 79/186 (42%), Gaps = 11/186 (5%) Query: 55 DNVAIKVIDKEKVL-KNKMIAQIKREIST-MKLIKHPNVIRMFEVMASKTKIYFVLEFVT 112 + IK ++++ K + ++ +I ++ H N +++ V EF Sbjct: 82 RSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAE 141 Query: 113 GGELFDK--ISSNGR---LKEDEARKYFQQLINAVDYCHS---RGVYHRDLKPENLLLDA 164 G + + + NG L K +++ NAV Y H+ + + HRD+KP ++ LD Sbjct: 142 HGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDK 201 Query: 165 NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFV 224 N K+SD S + + GT Y+ P + + + D++S G+ L V Sbjct: 202 NWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLV 260 Query: 225 LMAGYL 230 ++ G Sbjct: 261 IITGKP 266 >4I94-A nrPDB Length = 300 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 42/249 (16%), Positives = 91/249 (36%), Gaps = 24/249 (9%) Query: 44 KVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTK 103 V + +EN +A+K +++ ++ Q E + +++ + + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSR---QFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 104 IYFVLEFVTGGELFDKI--SSNGRLKEDEARKYFQQLINAVDYCHSRG-VYHRDLKPENL 160 + EF+ L + + +K + + A++YC S+G + DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 161 LLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGV 220 L D + ++S FGL + + + PE + G ++ ++S G Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYST------NLAFTPPEYLR-TGRVTPESVIYSFGT 212 Query: 221 ILFVLMAGY--LP------FEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPA 272 +L L++G P D N+ L + +F+ +L R L P Sbjct: 213 LLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDG--TELIRLASRCLQYEPR 270 Query: 273 TRITFAEVI 281 R ++ Sbjct: 271 ERPNPKSLV 279 >5UV4-A nrPDB Length = 311 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 40/206 (19%), Positives = 82/206 (39%), Gaps = 15/206 (7%) Query: 35 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 94 +G A ++NG + +K + + K + REI + ++HPN++ + Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKK---EFSREIKKLGSVRHPNLVPL 86 Query: 95 FEVM--ASKTKIYFVLEFVTGGELFDKISSN-----GRLKEDEARKYFQQLINAVDYCHS 147 + + + ++ L +S L + + +DY H+ Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 148 RGVY-HRDLKPENLLL-DANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE-VIN 204 V H ++K N+L+ ++ + V+D+ L L + + G Y PE Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLN-AGALGYSPPEFSST 205 Query: 205 NKGYDGAKADLWSCGVILFVLMAGYL 230 +K K+D+++ GVIL L+ G + Sbjct: 206 SKPCPSLKSDVYAFGVILLELLTGKI 231 >4OAU-C nrPDB Length = 699 Score = 99.2 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 108/301 (35%), Gaps = 57/301 (18%) Query: 54 GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVT 112 VA+K + + +RE+S ++ + + +++ + + + ++ + Sbjct: 366 KQEVAVKTF-------CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 113 GG---ELFDKISSNGRLKEDE-ARKYFQQLINAVDYCH-SRGVYHRDLKPENLLLDANGA 167 L + +EDE AR + AV H S G H+DL+P+N+L+D+ A Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 168 LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCG-VILFVLM 226 ++DF S G P EV K DL G ++L+V+ Sbjct: 479 AHLADFDKSI------------KWAGDPQ----EV---------KRDLEDLGRLVLYVVK 513 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 G + FED S + + + K LI R+ P R ++++ + +F Sbjct: 514 KGSISFEDLKAQSNEEVVQLSP-------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 566 Query: 287 KKGYKAPKFENADVSLDDVDAIFDDSG----------ESKNLVVERREEGLKTPV-TMNA 335 + + D+ +S E + + + + MN Sbjct: 567 WTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNK 626 Query: 336 F 336 F Sbjct: 627 F 627 >5UU1-A nrPDB Length = 324 Score = 98.9 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 89/234 (38%), Gaps = 34/234 (14%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVA---IKVIDKEK-------------VLKNKM 72 ++ LG+ +G G F + A + A +KV +E K+ + Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 73 IAQIKREISTMKLIKHPNVIRMFEV----MASKTKIYFVLEFVTGGELFDKISSNGRLKE 128 I+R K + + + + ++ + V+E + G +L NG K+ Sbjct: 76 KKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKK 129 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD--ANGALKVSDFGLSALP-----QQ 181 + ++++ ++Y H H D+K NLLL + ++D+GLS + Sbjct: 130 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 182 VREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDS 235 ++ GT + + + ++D+ G + + G LP+E + Sbjct: 190 QYQENPRKGHNGTIEFTSLDAHKGVA-LSRRSDVEILGYCMLRWLCGKLPWEQN 242 >4O1O-A nrPDB Length = 717 Score = 98.5 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 93/247 (37%), Gaps = 51/247 (20%) Query: 55 DNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK-HPNVIRMFEVMASKTKIYFVLEFVTG 113 VA+K + + ++E+S ++ + + NV+ + + + ++ L Sbjct: 370 QEVAVKRFS-------EGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY 422 Query: 114 GELFDKISSNG-----RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGAL 168 L + ++++ +++ AR L A+ H G H+DL+P+N+L+D+ Sbjct: 423 -TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGT 481 Query: 169 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCG-VILFVLMA 227 ++DF S + + K DL + G ++L+V+ Sbjct: 482 FLADFDKSIKWAEDPQ-------------------------KIKRDLEALGLLVLYVVKK 516 Query: 228 GYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDP--NPATRITFAEVIENEW 285 G + FE S + I + + LI + P N R++ ++ + + Sbjct: 517 GDISFETLKNQSFEEVIQGSP-------DEETRDLIHHLFHPGDNVEDRLS--SLLAHPF 567 Query: 286 FKKGYKA 292 F Sbjct: 568 FWSWESR 574 >5CLR-A nrPDB Length = 451 Score = 98.5 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 97/246 (39%), Gaps = 29/246 (11%) Query: 46 KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE-VMASKTKI 104 +++G +K + + + + + E T+ + R+ +T++ Sbjct: 96 FKVYALDDGKTYFLKSVK----IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 105 -YFVLEFVTGGELFDK---ISSNGRLKE-DEARKYFQQLINAVDYCHSRGVYHRDLKPEN 159 Y + F+ G +L + N LK E + + V H G+ HRDLKP N Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGN 206 Query: 160 LLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY--DGAKADLWS 217 ++LDA+ + DFG S+ ++ + + GT +Y+APE+ + + +DL++ Sbjct: 207 IMLDADMQCHLVDFGSSSSDKEPKP-----ASWGTASYLAPELNAQEDFIAFSQVSDLFA 261 Query: 218 CGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATR-IT 276 L L PF + I A + I ++ + R + Sbjct: 262 LAYSLDELFN---PFRQVKFAKVDIGIKNKHLVL---LHAEIEACITGLMSNETSVRTLY 315 Query: 277 FAEVIE 282 F+ +++ Sbjct: 316 FSRILQ 321 >2RSV-A nrPDB Length = 403 Score = 93.8 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 128/343 (37%), Gaps = 48/343 (13%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNV------AIKVIDKE------------KVLKN 70 ++++G +G+G F + A ++ + ++V +KV + + K Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 71 KMIAQIKREISTMKLIKHPNVIRMFEVMASKT----KIYFVLE-FVTGGELFDKISSN-G 124 + I + R + +K+ V + + + +++ F G +L +N Sbjct: 101 EQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAK 154 Query: 125 RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD--ANGALKVSDFGLS-----A 177 R + ++++ ++Y H H D+K NLLL+ + + D+GL+ Sbjct: 155 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 214 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL 237 + ++ GT + + + N + DL G + + G+LP+ED+ Sbjct: 215 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLK 273 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 Y + K + + L+ + P A+ +E + P +EN Sbjct: 274 DPKYVRDSKIRYR------ENIASLMDKCF-PEKNKPGEIAKYMETVKLLDYTEKPLYEN 326 Query: 298 A-DVSLDDVDAI-FDDSGESKNLVVERREEGLKTPVTMNAFEL 338 D+ L + AI D G+ VVE KT E+ Sbjct: 327 LRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEI 369 >2LAV-A nrPDB Length = 361 Score = 93.5 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 113/305 (37%), Gaps = 46/305 (15%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNV------AIKVIDKE------------KVLKN 70 ++++G +G+G F + A ++ + ++V +KV + + K Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 71 KMIAQIKREISTMKLIKHPNVIRMFEVMASKT----KIYFVLE-FVTGGELFDKISSN-G 124 + I + R + +K+ V + + + +++ F G +L +N Sbjct: 94 EQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAK 147 Query: 125 RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD--ANGALKVSDFGLS-----A 177 R + ++++ ++Y H H D+K NLLL+ + + D+GL+ Sbjct: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 Query: 178 LPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNL 237 + ++ GT + + + N + DL G + + G+LP+ED+ Sbjct: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWEDNLK 266 Query: 238 TSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFEN 297 Y + K + + L+ + P A+ +E + P +EN Sbjct: 267 DPKYVRDSKIRYR------ENIASLMDKCF-PEKNKPGEIAKYMETVKLLDYTEKPLYEN 319 Query: 298 ADVSL 302 L Sbjct: 320 LRDIL 324 >6EAS-A nrPDB Length = 308 Score = 88.4 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 36/270 (13%), Positives = 89/270 (32%), Gaps = 51/270 (18%) Query: 40 GTFAKVKFARN-VENGDNVAIK--VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 96 G+ + + + +G +A+ ++ K + +Q +++I+ + + H N + + Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLG 108 Query: 97 VMASKTKI--YFVLEFVTGGELFDKISSN--GRLKEDEARKYFQQLINAVDYCHSRGV-- 150 + V E+ G LF+ + +L + + +++ H Sbjct: 109 YCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPA 168 Query: 151 YHRDLKPENLLLDANGALKVSDFGL---SALPQQVREDGLLHTTCGTPNYVAPEVINNKG 207 R+ + L + A KVSD + + L + Sbjct: 169 ALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAFSP---------------- 212 Query: 208 YDGAKADLWS----CGVILFVLMAGYLPFEDSN-------------LTSLYKKIFKAEFT 250 D+ G++L ++ G +P + + L + I + Sbjct: 213 ------DMEDIVRKYGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGF 266 Query: 251 CPPWFSASAKKLIKRILDPNPATRITFAEV 280 P + + ++++ +D +P R EV Sbjct: 267 FPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 85.8 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 42/268 (15%), Positives = 95/268 (35%), Gaps = 39/268 (14%) Query: 37 LGEGTFAKVKFAR-----NVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 91 LGEG FA+V A + +N +KV + + Q+ + ++H Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK--PSMQHMF- 129 Query: 92 IRMFEVMASKTKIYFVLEFVTGGELFDKIS-----SNGRLKEDEARKYFQQLINAVDYCH 146 ++ + + V E + G L + I+ + + + +++ ++ H Sbjct: 130 MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVH 189 Query: 147 SRGVYHRDLKPENLLL-----------DANGALKVSDFGLSALPQQVREDGLLHTTCGTP 195 + H D+KP+N +L D + L + D G S + + + C T Sbjct: 190 DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETS 249 Query: 196 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL--------------PFEDSNLTSLY 241 + E+++NK ++ + D + ++ ++ G F ++ Sbjct: 250 GFQCVEMLSNKPWNY-QIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMW 308 Query: 242 KKIFKAEFTCPPWFSASAKKLIKRILDP 269 + F P + L+++ L Sbjct: 309 NEFFHVMLNIPDCHHLPSLDLLRQKLKK 336 >4IX6-A nrPDB Length = 350 Score = 80.7 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 55/322 (17%), Positives = 101/322 (31%), Gaps = 81/322 (25%) Query: 36 TLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN----V 91 LG G F V + +V +K + + +++ E+ + H N Sbjct: 27 PLGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLEC---EMDVNYHV-HANAKGTC 81 Query: 92 IRMFEVMA----SKTKIYF--VLE---FV---TGGELFDKISSNGRLKEDEA-------- 131 R + +IY + E + G + + G A Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 132 ----RKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN--GALKVSDFGLSALPQQVRED 185 +K ++L+ ++ H GV HRD+KP NL+ G LK+ D G +AL + E Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 186 GLLHTTCGT--PNY--------VAP--------------EVINNKGYDGAKADLWSCGVI 221 + G P Y + P E +D WS G + Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS-----WSAGCV 256 Query: 222 LFVLMA-------GYLPFEDS-----NLTSLYKKIFKAEFTCPPWFSASAK-----KLIK 264 + L G F + ++ E+ + + A L + Sbjct: 257 MLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQ 316 Query: 265 RILDPNPATRITFAEVIENEWF 286 R+++ R + + + +F Sbjct: 317 RLMEAERDARASCEAALSHAFF 338 >6G4J-A nrPDB Length = 315 Score = 71.9 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 81/225 (36%), Gaps = 41/225 (18%) Query: 15 STPSGSSSGGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA 74 S G++ G+ Y L + LG+G V A +G VA+KV + Sbjct: 12 SLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYLA-ETSDGH-VALKV--------SDDSL 61 Query: 75 QIKREISTMKLIKHPNVIRMFEVMASKTKIYF----------VLEFVTGGELFDKISSNG 124 I E++ +K + M Y +E++ G L +S G Sbjct: 62 SITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG 121 Query: 125 RLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANG-ALKVSDF-GLSALPQQV 182 + QL++++ H +G DLKP+NL++ ++ D G + + + Sbjct: 122 A---EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAI 178 Query: 183 REDGLLHTTCGTPNYVAPEVINNKGYDGAKA----DLWSCGVILF 223 +E + GY KA DL++ +I+ Sbjct: 179 KEYTEFYDRG------------YWGYGTRKAEPSYDLFAVAMIMI 211 >5GZ9-A nrPDB Length = 305 Score = 70.0 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 81/248 (32%), Gaps = 52/248 (20%) Query: 9 RSTPSRSTPSGSSSGGRTR-----------VGKYELGRTLGEGTFAKVKFARNVENGDNV 57 + SR P G GR R + + +GEG +V + E V Sbjct: 3 STADSRRCPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKE--HKV 60 Query: 58 AIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELF 117 A+ ++ + +M + +K ++ +V+ + + E+ G L Sbjct: 61 AL-----SRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGT--ILTEYHPLGSLS 113 Query: 118 DK-----ISSNGRL-KEDEARKYFQQLINAVDYCHSRGVYHRDLKPEN--------LLLD 163 + +S + + + ++ ++Y H + R + N LL Sbjct: 114 NLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLT 173 Query: 164 ANGALKVSDFGLSALPQQVREDGLLHTTCGTPN----YVAPEVI----NNKGY------- 208 +N ++ +D V D + CG +VAPE + + + Sbjct: 174 SNFSIVANDL---DALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPS 230 Query: 209 DGAKADLW 216 K D+W Sbjct: 231 YNEKVDIW 238 >6M7Z-A nrPDB Length = 319 Score = 69.6 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 71/192 (36%), Gaps = 23/192 (11%) Query: 104 IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD 163 + ++ ++ G + D + + + + ++ A+ H+ G+ HR ++ + + Sbjct: 121 LTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVL 178 Query: 164 ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV--------INNKGYDGAKADL 215 +G + + GL E L G APE+ +G K+D+ Sbjct: 179 PDGTVVLG--GLDTAAPIGTETRLWVGFFG--QETAPEIDRNFLADLALTQGRHTVKSDV 234 Query: 216 WSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRI 275 +S GV L+ L + + + S +++++ P R Sbjct: 235 YSLGVAFRNLV--QLLGNGNLGPEDRGAVRQDHLELLDKLS-------QKMIEEEPGNRP 285 Query: 276 TFAEVIENEWFK 287 T E++++ F+ Sbjct: 286 TIEEIMKDPLFE 297 >6BHC-A nrPDB Length = 438 Score = 68.8 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 96/272 (35%), Gaps = 57/272 (20%) Query: 56 NVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMA---------------- 99 N A+K+ + + + L H N+ + Sbjct: 85 NYAVKICKSKAKESQQYYHSL---AVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKK 141 Query: 100 SKTKIYFVLEFVTGGELFDKIS-------SNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 ++ + + V + D + + L E + QL + +++ V H Sbjct: 142 QRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTH 201 Query: 153 RDLKPENLLL-------------------DANGALKV--SDFGLSALPQQVREDGLLHTT 191 DL+ ENLLL ++ ++ S+F + + + +L Sbjct: 202 CDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ 261 Query: 192 CGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTC 251 +APE+I Y K D + G++++ ++ PF D N ++ +A+ Sbjct: 262 SR----LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF-DENPELKEREYTRADLPR 314 Query: 252 PPWFSA---SAKKLIKRILDPNPATRITFAEV 280 P+ S ++L +L+PNP+ RI ++ Sbjct: 315 IPFRSPYSRGLQQLASCLLNPNPSERILISDA 346 >5GZA-A nrPDB Length = 290 Score = 65.3 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 39/208 (18%), Positives = 76/208 (36%), Gaps = 34/208 (16%) Query: 34 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIR 93 + +G+G KV + G VA+ V+ ++ +S ++ ++ +V+ Sbjct: 30 VKLIGQGAVKKVYLSE--WQGQKVALSVLS-----SDQYADDFLHGLSMLRALQSSHVVT 82 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + V FV E+ G + ++ + + + +L A+DY H Sbjct: 83 LVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 154 DLKPENLLLDANGALK-VSDFGLSALPQQVRED---------GLLHTTCG----TPNYVA 199 ++ D+N K +S F L++ + + D G L CG T ++VA Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFVA 200 Query: 200 PEVI-----------NNKGYDGAKADLW 216 PE + K D+W Sbjct: 201 PEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EWX-A nrPDB Length = 484 Score = 65.0 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 70/234 (29%), Gaps = 55/234 (23%) Query: 99 ASKTKIYFVLEFVTGGELFDKIS-------SNGRLKEDEARKYFQQLINAVDYCHSRGVY 151 + + + V D + + + E QL N +++ G+ Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 152 HRDLKPENLLLDANG-----------------------------------------ALKV 170 HRDL ENLLL L + Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 171 SDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYL 230 S+F + + + +APE+++ Y K D + G++++ L+ Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQAR---LAPEIVSASQY--RKFDEFQTGILIYELLHQPN 347 Query: 231 PFEDSNLTSLYKKIFKAEFTCP--PWFSASAKKLIKRILDPNPATRITFAEVIE 282 PFE + P +S ++L +L+ +P RI E Sbjct: 348 PFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 >4CI6-B nrPDB Length = 643 Score = 63.8 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 94/271 (34%), Gaps = 44/271 (16%) Query: 51 VENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI-KHPNVIRMFE--VMASKTKIY-- 105 + VA K+ + + + + A+++ K KHPN+ + V+ + Y Sbjct: 66 KDKQRLVA-KI--ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 106 FVLEFVTG-------GELFDKISSNGRLKED---EARKYFQQLINAVDYCHSRGVYHRDL 155 +++ V G L D E + +L++ ++ G+ H D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 156 KPENLLLD-ANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 214 KP N++ D A+G V D GL R T ++ APE+ K+D Sbjct: 183 KPGNVVFDRASGEPVVIDLGL-----HSRSGEQPKGF--TESFKAPELGVGNLGASEKSD 235 Query: 215 LWSCGVILFVLMAGYLPFEDSNLTS---------------LYKKIFKAEFTCPPWFSASA 259 ++ +++ L+ G FE + + + + Sbjct: 236 VF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAY 292 Query: 260 KKLIKRILDPNPATRITFAEVIENEWFKKGY 290 + I IL + +R E +E+ G Sbjct: 293 TRFITDILGVSADSRPDSNEARLHEFLSDGT 323 >3BYV-A nrPDB Length = 377 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 33/204 (16%), Positives = 72/204 (35%), Gaps = 29/204 (14%) Query: 116 LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 L S++ L + Q+I + H G+ H L+P +++LD G + ++ F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF-- 250 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA----------DLWSCGVILFVL 225 + + DG + + + PE+ + D W+ G++++ + Sbjct: 251 ----EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWI 306 Query: 226 MAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEW 285 LP + IF++ P + L++ L R+ + +E Sbjct: 307 WCADLPITKDAALGGSEWIFRSCKNIPQ----PVRALLEGFLRYPKEDRLLPLQAME--- 359 Query: 286 FKKGYKAPKFENADVSLDDVDAIF 309 P++E L ++ Sbjct: 360 ------TPEYEQLRTELSAALPLY 377 >3DZO-A nrPDB Length = 413 Score = 61.5 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 72/208 (34%), Gaps = 28/208 (13%) Query: 116 LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 L S++ L + Q+I + H G+ H L+P +++LD G + ++ F Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF-- 255 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPEVINNKGYD---------GAKADLWSCGVILFVLM 226 VR+ + G + PE + D W+ G+ ++ + Sbjct: 256 ---EHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIW 311 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 LP D + IF++ P + L++ L R+ + +E Sbjct: 312 CADLPNTDDAALGGSEWIFRSCKNIPQ----PVRALLEGFLRYPKEDRLLPLQAME---- 363 Query: 287 KKGYKAPKFENADVSLDDVDAIFDDSGE 314 P++E L ++ GE Sbjct: 364 -----TPEYEQLRTELSAALPLYQTDGE 386 >2JII-A nrPDB Length = 352 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 60/147 (40%), Gaps = 12/147 (8%) Query: 95 FEVMASKTKIYFVLEFVTGGELFDKI--SSNGRLKEDEARKYFQQLINAVDYCHSRGVYH 152 F V K + VL + G L + S L E + +L++A+++ H H Sbjct: 125 FGVHQDK-YRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVH 182 Query: 153 RDLKPENLLLD--ANGALKVSDFGLS-----ALPQQVREDGLLHTTCGTPNYVAPEVINN 205 ++ EN+ +D + ++ +G + + +G G +++ ++ Sbjct: 183 GNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKG 242 Query: 206 KGYDGAKADLWSCGVILFVLMAGYLPF 232 G ++DL S G + + G+LP+ Sbjct: 243 CG-PSRRSDLQSLGYCMLKWLYGFLPW 268 >2W1Z-A nrPDB Length = 368 Score = 58.0 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 70/208 (33%), Gaps = 28/208 (13%) Query: 116 LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGL 175 L S++ L + QLI G+ H D + N+LLD G + ++ F Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGF-- 235 Query: 176 SALPQQVREDGLLHTTCGTPNYVAPE-----VINNKGYD----GAKADLWSCGVILFVLM 226 VR+ + G + PE ++ + + D W+ G+ ++ + Sbjct: 236 ---EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIW 291 Query: 227 AGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWF 286 LP + + I C + L++ L + R+ + +E Sbjct: 292 CADLP---NTEDAELGGIEWIYRRCK-NIPQPVRALLEGFLRYSKEDRLLPLQAME---- 343 Query: 287 KKGYKAPKFENADVSLDDVDAIFDDSGE 314 ++E L V ++ GE Sbjct: 344 -----TSEYEQLRTELSAVLPLYQTDGE 366 >4CYJ-A nrPDB Length = 438 Score = 57.2 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 61/141 (43%), Gaps = 17/141 (12%) Query: 45 VKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTK- 103 V A+N NG + A++ ++ ++ K I + ++ K IK+ +++ + EV ++ Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKD---WKKIKNASIVTIHEVFTTREFG 127 Query: 104 ---IYFVLEFVTGGELF----------DKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 + F +F + ++ + E+ Y Q+ NA+ HS + Sbjct: 128 DSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRL 187 Query: 151 YHRDLKPENLLLDANGALKVS 171 R L+P ++L +++S Sbjct: 188 AARCLEPSKIILTDINRIRLS 208 >4AZW-A nrPDB Length = 471 Score = 56.1 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 60/141 (42%), Gaps = 22/141 (15%) Query: 42 FAK--VKF--ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL----IKHPNVIR 93 F + V ++ +G ++ E+ +NK ++ EI + P Sbjct: 258 FGEDYVCKFFYYDMPHG------ILTAEESQRNKH--ELHNEIKFLTQPPAGFDAP---A 306 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + + + V+E + G L D +++ +E + K L+ ++ +G +H Sbjct: 307 VLAHGENAQSGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHD 363 Query: 154 DLKPENLLLDANGALKVSDFG 174 D++P N+++DA ++ DFG Sbjct: 364 DVRPWNVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 55.7 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 60/141 (42%), Gaps = 22/141 (15%) Query: 42 FAK--VKF--ARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL----IKHPNVIR 93 F + V ++ +G ++ E+ +NK ++ EI + P Sbjct: 258 FGEDYVCKFFYYDMPHG------ILTAEESQRNKY--ELHNEIKFLTQPPAGFDAP---A 306 Query: 94 MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 153 + + + V+E + G L D +++ +E + K L+ ++ +G +H Sbjct: 307 VLAHGENAQSGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHD 363 Query: 154 DLKPENLLLDANGALKVSDFG 174 D++P N+++DA ++ DFG Sbjct: 364 DVRPWNVMVDARQHARLIDFG 384 >4CZY-B nrPDB Length = 429 Score = 54.9 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 63/141 (44%), Gaps = 19/141 (13%) Query: 46 KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMAS----K 101 A+N +NG + A++ I+ ++ K I + +E K I + N++ + E + Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 102 TKIYFVLEFVTGGE-LFDK----------ISSNGRLKEDEARKYFQQLINAVDYCHSRGV 150 + + FV +F E L+D + + ++ E+ Y Q+ NA+ H+ + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 151 YHRDLKPENLLLDANGALKVS 171 R L+ + + N ++++ Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >3ENH-A nrPDB Length = 540 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 34/155 (21%), Positives = 59/155 (38%), Gaps = 21/155 (13%) Query: 37 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIK-----REISTMKLIKHPNV 91 +G+G A +K R+ +V IK K+ ++ I+ RE + L+K + Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 92 IR--MFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 149 +F+V +I + ++ G D I N ++ V H Sbjct: 402 PAPYIFDVDLDNKRIM--MSYINGKLAKDVIEDN--------LDIAYKIGEIVGKLHKND 451 Query: 150 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVRE 184 V H DL N + D + L + DFGL + + Sbjct: 452 VIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDED 484 >6G38-A nrPDB Length = 357 Score = 50.7 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 57/178 (32%), Gaps = 50/178 (28%) Query: 29 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVI-----DKEKVLKNKMIAQIKREISTM 83 K + +GEG F +V + + + VAIK+I D K +I EI Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 84 KL-----------------IKHPNVIR------MFEV----------------MASKTKI 104 K + + ++ + + ++ Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 105 YFVLEFVTGG-ELFDKISSNGRLKEDEARKYFQQLINAVDYCH-SRGVYHRDLKPENL 160 + VLEF GG +L + L A+ QL ++ S HRDL N+ Sbjct: 159 FIVLEFEFGGIDLEQMRTKLSSLA--TAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4WWA-A nrPDB Length = 261 Score = 49.5 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 56/167 (33%), Gaps = 32/167 (19%) Query: 46 KFARNVENGDNVAIKVIDKEKVLKNKMIA-----QIKREISTMKLIKHPNVI------RM 94 R ++ IK ++ ++ + E + + +I ++ Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 95 FEVMASKTKIYFVL--EFVTGG----ELFDKISSNGR-----LKEDEARKYFQQLINAVD 143 I+ E + GG L + + + + L RK +Q+ + Sbjct: 95 IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL- 151 Query: 144 YCHSRGVYHRDLKPENLLLDANG---ALKVSDFGLSALPQQVREDGL 187 H H DL N++L +G + DFGL ++ V + G+ Sbjct: 152 -LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGV 197 >5VE6-A nrPDB Length = 492 Score = 48.8 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 18/35 (51%) Query: 128 EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL 162 E QL N +++ G+ HRDL ENLLL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 45.3 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 8/89 (8%) Query: 198 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP----P 253 +APE+++ Y K D + G++++ L+ PFE L ++ ++ E P Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFE--VRAQLRERDYRQEDLPPLPALS 380 Query: 254 WFSASAKKLIKRILDPNPATRITFAEVIE 282 +S ++L +L+ +P RI E Sbjct: 381 LYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4BWP-A nrPDB Length = 448 Score = 46.8 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 25/166 (15%), Positives = 50/166 (30%), Gaps = 43/166 (25%) Query: 46 KFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASK---- 101 A + G ++ I ++ K + + K ++H NV+++ EV +K Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL----VEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 102 TKIYFVLEFVTG-----------------------GELFDKISSNGR--------LKEDE 130 + V ++ G GE + L E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 131 ARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAN----GALKVSD 172 QL + H G+ + L P +++ + +SD Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3Q60-A nrPDB Length = 371 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 53/310 (17%), Positives = 93/310 (30%), Gaps = 65/310 (20%) Query: 30 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 89 K +L L G + V R+VE ++ A+KV + ++ E + Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLH-EATFAAA---- 117 Query: 90 NVIRMFE-------------------VMASKTKI--------------YFVLEFVTGGEL 116 R+ + S+ Y +L +L Sbjct: 118 ---RLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDL 174 Query: 117 ------FDKISSNGRLKEDEARKYF-QQLINAVDYCHSRGVYHRDLKPENLLLDANGALK 169 D + + A QLI S+G+ H P+NL + +G L Sbjct: 175 ELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLM 234 Query: 170 VSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKA-DLWSCGVILFVLMAG 228 + D + +V G + T Y E +N A + W G+ ++ + Sbjct: 235 LGD---VSALWKVGTRGPASSVPVT--YAPREFLNASTATFTHALNAWQLGLSIYRVWCL 289 Query: 229 YLPFEDSNLTSLYKKIFKAEFTCP----------PWFSASAKKLIKRILDPNPATRITFA 278 +LPF + + P K LI R L+ + R+ Sbjct: 290 FLPF-GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPL 348 Query: 279 EVIENEWFKK 288 E +E F + Sbjct: 349 EAMETPEFLQ 358 >4OTP-A nrPDB Length = 352 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 63/187 (33%), Gaps = 32/187 (17%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH--- 88 E+ + G A V A + NG++ AIK+ ++ + E +H Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 93 Query: 89 ----------------PNVIRMFEVMASKTK------IYFVLEFVTGGELFDKISSNGRL 126 N+IR+ + V+ F+ ++ + N +L Sbjct: 94 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 153 Query: 127 KEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 E +AR+ + Q+I + + + H DL N+L G + + D S Sbjct: 154 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGG-VYIIDVSQSVEHDHPHAL 212 Query: 186 GLLHTTC 192 L C Sbjct: 213 EFLRKDC 219 >1TQM-A nrPDB Length = 282 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 61/155 (39%), Gaps = 26/155 (16%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVA---------IKVIDKEKVLKNKM-----IAQIKR 78 +G+ +GEG + V + + G+ V K + +++ + I + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 79 EISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQL 138 E ++ ++ V +++ + ++E + EL+ N DE + Sbjct: 154 EFRALQKLQGLAVPKVYAWEGNA----VLMELIDAKELYRVRVEN----PDEVLDM---I 202 Query: 139 INAVDYCHSRGVYHRDLKPENLLLDANGALKVSDF 173 + V + RG+ H DL N+L+ G + + DF Sbjct: 203 LEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >6G5I-z nrPDB Length = 568 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 63/187 (33%), Gaps = 32/187 (17%) Query: 32 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH--- 88 E+ + G A V A + NG++ AIK+ ++ + E +H Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 235 Query: 89 ----------------PNVIRMFEVMASKTK------IYFVLEFVTGGELFDKISSNGRL 126 N+IR+ + V+ F+ ++ + N +L Sbjct: 236 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 295 Query: 127 KEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED 185 E +AR+ + Q+I + + + H DL N+L G + + D S Sbjct: 296 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGG-VYIIDVSQSVEHDHPHAL 354 Query: 186 GLLHTTC 192 L C Sbjct: 355 EFLRKDC 361 >1ZP9-A nrPDB Length = 258 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 42/206 (20%), Positives = 69/206 (33%), Gaps = 33/206 (16%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNV--AIKVIDKEKVLKNKMIAQIK-REISTMKLIK-- 87 +G + G A V +A V +G V A+K+ E +KM + E M+ I Sbjct: 51 MGGVISTGKEANVFYADGVFDGKPVAMAVKIYRIETSEFDKMDEYLYGDERFDMRRISPK 110 Query: 88 ----------HPNVIRMFEVMASKTKIY------FVLEFVTGGEL--FDKISSNGRLKED 129 N+ R E S + Y ++EF+ EL + LKE Sbjct: 111 EKVFIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKEL 170 Query: 130 EARKYFQQLINAVDYCHSRG-VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLL 188 + F ++ V + + H DL N++ + D G + + + L Sbjct: 171 DVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDK--VYFIDMGQAVTLRHPMAESYL 228 Query: 189 HTTCGTPNYVAPEVINNKGYDGAKAD 214 +I G KAD Sbjct: 229 ERDVR-------NIIRFFSKYGVKAD 247 >5YK0-A nrPDB Length = 452 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 54/176 (30%), Gaps = 54/176 (30%) Query: 43 AKVKFARNVENGDNVAIKV----------------------------------IDKEKVL 68 +V A +G VA+K+ + E V Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 69 KNKMIAQIKREISTMKLI-----KHP-----NVIRMFEVMASKTKIYFVLEFVTGGELFD 118 + +M + E + + HP +V+ + + E++ G + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVV-------ASAPKVVIQEWIEGVPMAE 257 Query: 119 KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFG 174 I + D +L D G+ H D P N +L +G + + DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4BVU-A nrPDB Length = 211 Score = 38.4 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 51/147 (34%), Gaps = 23/147 (15%) Query: 33 LGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVI 92 LG+ +G+G+ A++ N + K D N+++ +E Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFN-------- 92 Query: 93 RMFE-----VMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 147 + V+ +Y + V G L D + ++ Y Q + + Sbjct: 93 AFYGDEASVVIQYGGDVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK----LNE 146 Query: 148 RGVYHRDLKPENLLLD-ANGALKVSDF 173 + H DL N+L D + +L DF Sbjct: 147 LSIIHYDLNTGNMLYDKESESLFPIDF 173 >6FAI-l nrPDB Length = 425 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 59/190 (31%), Gaps = 39/190 (20%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKV-----------------IDKEKVLKNKMI 73 Y +G T+G G + + + V +K+ + K N M Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 74 AQ---IKREISTMKLIKHPNVIRMFEVMA--SKTKIYFVLEFVTGGELFDKISSNGRLKE 128 +E M ++ F+V ++ V+E + G + ++ + + Sbjct: 154 LSRLAANKEYQFMSMLYSKG----FKVPEPFDNSRHIVVMELIEGYPMR-RLRKHKNIP- 207 Query: 129 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL------DANGALKVSDFGLSALPQQV 182 K + L+ + + G+ H D N+++ + + V DF Q Sbjct: 208 ----KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQ 263 Query: 183 REDGLLHTTC 192 D Sbjct: 264 DADYYFQRDV 273 >6G18-v nrPDB Length = 552 Score = 33.8 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 28/75 (37%), Gaps = 6/75 (8%) Query: 99 ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPE 158 + V+E + G L ++ + + + + + G+ H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHH------VEDPASVYDEAMELIVKLANHGLIHGDFNEF 232 Query: 159 NLLLDANGALKVSDF 173 NL+LD + + + DF Sbjct: 233 NLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 33.8 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 28/75 (37%), Gaps = 6/75 (8%) Query: 99 ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPE 158 + V+E + G L ++ + + + + + G+ H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHH------VEDPASVYDEAMELIVKLANHGLIHGDFNEF 232 Query: 159 NLLLDANGALKVSDF 173 NL+LD + + + DF Sbjct: 233 NLILDESDHITMIDF 247 >4GYG-A nrPDB Length = 397 Score = 32.6 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 23/177 (12%), Positives = 49/177 (27%), Gaps = 48/177 (27%) Query: 31 YELGRTLGEGTFAKVKFARNVENGDNVAIKV-----------------IDKEKVLKNKMI 73 Y +G +G G + + + + V +K+ + + Sbjct: 97 YSVGSRIGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNRSTGSWMYL 155 Query: 74 AQI--KREISTMKLIKHPNVIRMFEVMASKTKIY-----FVLEFVTGGELFDKISSNGRL 126 +++ +E + MK + E I V+ L D + Sbjct: 156 SRLAAIKEFAFMKAL-------YEEGFPVPEPIAQSRHTIVM------SLVDALPMRQVS 202 Query: 127 KEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALK----------VSDF 173 + + LI + G+ H D N+L+ + + DF Sbjct: 203 SVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >5MRF-Q nrPDB Length = 296 Score = 31.4 bits (70), Expect = 0.88, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 27/80 (33%), Gaps = 5/80 (6%) Query: 350 LFEKQMGLVKRKTRFTSKSSANEIVTKIEAAAAPMGFDVKTNNYKM----KLTGEKSGRK 405 L + + +F KS+ + + ++ F + +K ++ K Sbjct: 18 LGNRPKNFLPHSEKFIKKSTPEFMKSDLKEVDEKTSFKSEKE-WKFIPGDRVVVMSGASK 76 Query: 406 GQLAVATEVFQVAPSLYMVE 425 G +AV + S + E Sbjct: 77 GNIAVIKSFDKRTNSFILDE 96 >4IFQ-A nrPDB Length = 970 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 33/88 (37%), Gaps = 8/88 (9%) Query: 55 DNVAIK-VIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTG 113 + VA + ++ + N + R ++++ ++ T++Y E + Sbjct: 87 EIVACELILSGDTTANNGKVQYFLRRQYILQIVS--FIVN---CFHEDTELY--QELIKN 139 Query: 114 GELFDKISSNGRLKEDEARKYFQQLINA 141 G L I S + + + QQ+ A Sbjct: 140 GALVSNILSAFKFIHTQLSEIKQQINKA 167 >2COY-A nrPDB Length = 112 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 20/77 (25%), Positives = 30/77 (38%), Gaps = 6/77 (7%) Query: 1 MASRTTPSRS-TPSRSTPSGSSSGGRTRVGKYELGRTLGEGTFAKVKF--ARNVENGDNV 57 MA S TPS S S +S RVG +G+G V + A G V Sbjct: 8 MAQSKRHVYSRTPSGSRMSAEASARPLRVG--SRVEVIGKGHRGTVAYVGATLFATGKWV 65 Query: 58 AIKVIDKEKVLKNKMIA 74 + ++D+ K + + Sbjct: 66 GV-ILDEAKGKNDGTVQ 81 >6DFL-A nrPDB Length = 259 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 28/81 (34%), Gaps = 3/81 (3%) Query: 101 KTKIYFVLE-FVTGGEL--FDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKP 157 + + V E +L F + R + + V H GV HRD Sbjct: 107 RQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYI 166 Query: 158 ENLLLDANGALKVSDFGLSAL 178 + LL + + DF LS + Sbjct: 167 CHFLLHTDKPVSADDFRLSVI 187 >6EF6-A nrPDB Length = 354 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 17/28 (60%), Gaps = 3/28 (10%) Query: 149 GVYHRDLKPENLLLDAN---GALKVSDF 173 G+ H DL+ NLL+D++ + V DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >2QG7-A nrPDB Length = 458 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 37/102 (36%), Gaps = 19/102 (18%) Query: 60 KVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDK 119 K + + K I +RE ++ + N+ + V + + + EF+ G L + Sbjct: 135 KYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGR---IEEFMDGYALSRE 191 Query: 120 ISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKP-ENL 160 N + + + + + H D+K ENL Sbjct: 192 DIKNPKFQ--------KLIAKNLKLLH-------DIKLNENL 218 >3NPK-A nrPDB Length = 291 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 18/40 (45%), Gaps = 4/40 (10%) Query: 116 LFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 155 L + SN ++A + A+++ H+ + H DL Sbjct: 47 LLSVVQSNKPELLNQAL----DVALALEFIHTYSLIHDDL 82 >3SN5-A nrPDB Length = 491 Score = 28.7 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 35/232 (15%), Positives = 79/232 (34%), Gaps = 25/232 (10%) Query: 215 LWSCGV-ILFVL----MAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILDP 269 ++S ++F + G + F A L + Sbjct: 154 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRT 213 Query: 270 NPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKN-LVVERREEGLK 328 R AE + +E +K + + + L+D + FDD ++K LVV + Sbjct: 214 AHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANT 273 Query: 329 TPVTM-NAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSA---------------NE 372 P T + F++I + + + E + L + + + + + Sbjct: 274 IPATFWSLFQMIRNPEAMK-AATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 332 Query: 373 IVTKIEAAAAPMGFDVKTNNYKMKLT-GEKSGRKGQ-LAVATEVFQVAPSLY 422 I + ++A + ++ + L G + RK +A+ ++ + P +Y Sbjct: 333 IKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 384 >4JTA-B nrPDB Length = 514 Score = 28.7 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 35/94 (37%), Gaps = 16/94 (17%) Query: 270 NPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKT 329 +P R+ + + + NE+F F+ S D + + G R + Sbjct: 80 DPKKRMRYFDPLRNEYF--------FDRNRPSFDAILYYYQSGG--------RLRRPVNV 123 Query: 330 PVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTR 363 P+ + + E+ G +F + G +K + R Sbjct: 124 PLDIFSEEIRFYELGEEAMEMFREDEGYIKEEER 157 >2A79-B nrPDB Length = 499 Score = 28.7 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 35/94 (37%), Gaps = 16/94 (17%) Query: 270 NPATRITFAEVIENEWFKKGYKAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKT 329 +P R+ + + + NE+F F+ S D + + G R + Sbjct: 61 DPKKRMRYFDPLRNEYF--------FDRNRPSFDAILYYYQSGG--------RLRRPVNV 104 Query: 330 PVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTR 363 P+ + + E+ G +F + G +K + R Sbjct: 105 PLDIFSEEIRFYELGEEAMEMFREDEGYIKEEER 138 >5L3X-B nrPDB Length = 405 Score = 28.4 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 32/73 (43%), Gaps = 7/73 (9%) Query: 76 IKREISTMKLIKHPNVIRMF-EVMASKTKIYFVLEFVT-GGELFD---KISSNGRLKEDE 130 + EIST + HP V+++ ++ ++ V+E + L D + S G + Sbjct: 269 LLDEISTCHQLLHPQVLQLLVKLFETEHSALDVMEQLELKKTLLDRMVHLLSRGYVLP-- 326 Query: 131 ARKYFQQLINAVD 143 Y ++ + +D Sbjct: 327 VVSYIRKCLEKLD 339 >4UXD-A nrPDB Length = 297 Score = 28.4 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 21/65 (32%), Gaps = 18/65 (27%) Query: 43 AKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLI---KHPNVIRMFEVMA 99 V+ +N +A+K+ + I MK + + PN +E Sbjct: 233 GIVRLYHEYKNNREMALKIEKNDV-------------IPLMKKLGKYQFPN--AYYEYFY 277 Query: 100 SKTKI 104 K I Sbjct: 278 KKNNI 282 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.147 0.427 Lambda K H 0.267 0.0450 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,795,366 Number of Sequences: 36641 Number of extensions: 863098 Number of successful extensions: 6822 Number of sequences better than 10.0: 515 Number of HSP's better than 10.0 without gapping: 950 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2602 Number of HSP's gapped (non-prelim): 1214 length of query: 482 length of database: 10,336,785 effective HSP length: 101 effective length of query: 381 effective length of database: 6,636,044 effective search space: 2528332764 effective search space used: 2528332764 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (28.0 bits)