BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q92466 (427 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4E5Z-B nrPDB 877 0.0 3EI3-B nrPDB 405 e-113 4A11-B nrPDB 59 4e-09 5GAN-H nrPDB 50 2e-06 6GMH-W nrPDB 50 2e-06 5WJC-A nrPDB 50 3e-06 5FVM-C nrPDB 49 3e-06 4XYI-A nrPDB 48 7e-06 4V8M-A7 nrPDB 47 1e-05 6EMK-B nrPDB 47 2e-05 5OPT-p nrPDB 45 5e-05 3FM0-A nrPDB 45 6e-05 5I2T-A nrPDB 44 1e-04 5WLC-LO nrPDB 44 1e-04 2H9P-A nrPDB 44 1e-04 5M25-A nrPDB 44 2e-04 6HHQ-h nrPDB 42 7e-04 5Y1U-A nrPDB 41 8e-04 6MZM-G nrPDB 41 8e-04 6F3T-A nrPDB 41 8e-04 3C9C-A nrPDB 41 0.001 3CFV-B nrPDB 41 0.001 2HES-X nrPDB 40 0.001 5NNZ-B nrPDB 40 0.001 5CXC-A nrPDB 40 0.002 6QX9-4B nrPDB 40 0.002 3JB9-g nrPDB 40 0.002 5WBU-D nrPDB 40 0.002 5OV3-A nrPDB 40 0.003 4LG8-A nrPDB 40 0.003 5UZ7-B nrPDB 39 0.005 6HQA-B nrPDB 39 0.005 4BTS-AR nrPDB 39 0.006 5BJS-A nrPDB 38 0.006 5Z56-q nrPDB 38 0.007 6Q8F-A nrPDB 38 0.007 5FL8-q nrPDB 38 0.007 4V7E-Bg nrPDB 37 0.011 1VYH-C nrPDB 37 0.015 5Y88-O nrPDB 37 0.016 5MZH-A nrPDB 37 0.017 6QX9-5O nrPDB 37 0.020 3DW8-B nrPDB 37 0.020 2YNP-A nrPDB 37 0.024 5WYK-BB nrPDB 36 0.032 3MKQ-A nrPDB 35 0.058 5NZU-C nrPDB 35 0.060 2AQ5-A nrPDB 35 0.065 3JB9-S nrPDB 35 0.068 5OQL-d nrPDB 35 0.072 6BX3-B nrPDB 35 0.077 5OQL-J nrPDB 35 0.091 6ID0-T nrPDB 34 0.12 6EOJ-D nrPDB 34 0.12 5XYI-g nrPDB 34 0.12 4V6W-Ag nrPDB 34 0.14 5WLC-LJ nrPDB 33 0.18 5WYJ-BC nrPDB 33 0.20 3DM0-A nrPDB 33 0.26 5WYJ-BE nrPDB 32 0.37 3JAP-g nrPDB 32 0.41 5A9Q-2 nrPDB 32 0.44 5FA5-B nrPDB 32 0.45 6QDV-o nrPDB 32 0.57 5YZG-W nrPDB 32 0.62 3JB9-L nrPDB 31 1.1 3I2N-A nrPDB 31 1.1 6G51-g nrPDB 31 1.2 1NR0-A nrPDB 30 1.4 6EM1-m nrPDB 30 1.4 4G56-B nrPDB 30 1.5 6C0F-s nrPDB 30 1.6 1S5J-A nrPDB 30 1.7 6CB1-s nrPDB 30 2.0 6J6H-n nrPDB 30 2.7 5OQL-L nrPDB 29 3.2 6ELZ-p nrPDB 29 3.3 1TMO-A nrPDB 29 3.4 5OQL-X nrPDB 29 3.6 5MWJ-A nrPDB 29 3.6 6E29-D nrPDB 29 4.3 4PSX-B nrPDB 29 4.7 >4E5Z-B nrPDB Length = 436 Score = 877 bits (2266), Expect = 0.0, Method: Compositional matrix adjust. Identities = 422/423 (99%), Positives = 422/423 (99%), Gaps = 1/423 (0%) Query: 6 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP 65 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP Sbjct: 14 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP 73 Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 125 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS Sbjct: 74 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 133 Query: 126 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD Sbjct: 134 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 193 Query: 186 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV 245 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV Sbjct: 194 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV 253 Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 305 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT Sbjct: 254 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 313 Query: 306 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 365 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT Sbjct: 314 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 373 Query: 366 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS-QEEAR 424 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS QEEAR Sbjct: 374 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSEQEEAR 433 Query: 425 TRK 427 TRK Sbjct: 434 TRK 436 >3EI3-B nrPDB Length = 383 Score = 405 bits (1040), Expect = e-113, Method: Compositional matrix adjust. Identities = 192/369 (52%), Positives = 270/369 (73%), Gaps = 4/369 (1%) Query: 56 GLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRAT 115 G G Q SI+ +++ LG++ ++Q LQ+ F+ +L SY++ + A+PFDRR T Sbjct: 18 GRTGGQKKVGQTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVT 77 Query: 116 SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYAS 175 SL WHPTHP+TVAVGSKGGDI+LW++ +++K +FI+G+G G +ITG+KFN NTNQ + S Sbjct: 78 SLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFVS 137 Query: 176 SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL 235 S+ G T L+DF G++++VFA +D+ + W+C +DVS S +M+ TGD+ G ++LL +DG E+ Sbjct: 138 SIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEI 197 Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 + ++HK KVTH NP CDW +AT+SVD TVK+WDLR ++ K S++ +PH PVNAA Sbjct: 198 FKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAY 257 Query: 296 FSP-DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 354 F+P D +LLTTDQ++EIRVYS+ W P +I HPHR FQHLTPIKA WHP Y+LIV G Sbjct: 258 FNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAG 317 Query: 355 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH 414 RYPD + RTID++D NSG ++ QL DP ++GI SLN+F+P GD LAS MG++ Sbjct: 318 RYPDDQL---LLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN 374 Query: 415 ILIWSQEEA 423 ILIW++E+ Sbjct: 375 ILIWNREDT 383 >4A11-B nrPDB Length = 408 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/184 (27%), Positives = 88/184 (47%), Gaps = 20/184 (10%) Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR---VFASSDTINIWFCSLDVSASSR 214 S+ +++ P +T F +SS + T ++ D N L+ VF +T+ S VS Sbjct: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWD--TNTLQTADVFNFEETVYSHHMS-PVSTKHC 157 Query: 215 MVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 +V G V L ++ + L+ H++++ V+ +P D+ LATAS D VK+WD+R Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 Query: 274 QVRG-------------KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 320 + G +A + H VN CF+ DG LLT + +R++++S Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 Query: 321 DCPL 324 + L Sbjct: 278 ENTL 281 >5GAN-H nrPDB Length = 465 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 77/328 (23%), Positives = 139/328 (42%), Gaps = 27/328 (8%) Query: 9 TQKTSEIVLRPRN------KRSRSPLELEPEA-KKLCAKGSGPSRRCDSDCLW-VGLAGP 60 T TSE++ R +RSR L+ E E +K + SRR + + + LAG Sbjct: 111 TPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGS 170 Query: 61 QILP--PCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLA 118 Q++ P ++ + + SW Q L L L QK + ++ Sbjct: 171 QLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPL-----TQKLDSHVGKIGAID 225 Query: 119 WHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG--IGAGGSITGLKFNPLNTNQFYAS- 175 WHP + + ++ G I + + ++ + G +G I+ +K++P + +F S Sbjct: 226 WHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP--SGKFIGSA 283 Query: 176 SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKE 234 S + T RL D + + ++ S S +V +G +L ++ G + Sbjct: 284 SHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGS--LVCSGGMDSLSMLWDIRSGSK 341 Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 294 + L H K + VA +P + +AT D + +WD+R+ R + L HR+ V Sbjct: 342 VMTLAGHSKPIYTVAWSPNG-YQVATGGGDGIINVWDIRK-RDEGQLNQILAHRNIVTQV 399 Query: 295 CFSPD--GARLLTTDQKSEIRVYSASQW 320 FS + G +L++ + I VYS+ W Sbjct: 400 RFSKEDGGKKLVSCGYDNLINVYSSDTW 427 >6GMH-W nrPDB Length = 305 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/144 (25%), Positives = 71/144 (49%), Gaps = 9/144 (6%) Query: 174 ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-G 232 +SS++ RL D + + ++ W +L S S+ + TG +VG V + ++ G Sbjct: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDAW--TLAFSPDSQYLATGTHVGKVNIFGVESG 138 Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPV 291 K+ ++L K + +A +P +LA+ ++D + I+D+ L++L H P+ Sbjct: 139 KKEYSLDTRGKFILSIAYSPDGK-YLASGAIDGIINIFDI----ATGKLLHTLEGHAMPI 193 Query: 292 NAACFSPDGARLLTTDQKSEIRVY 315 + FSPD L+T I++Y Sbjct: 194 RSLTFSPDSQLLVTASDDGYIKIY 217 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 58/120 (48%), Gaps = 10/120 (8%) Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVD 264 SL S S+++VT + G + + ++ L L H V +VA P D ++S D Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPD-DTHFVSSSSD 253 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPL 324 ++VK+WD+ +F H+ V ++ +G+++++ EI +Y DCP+ Sbjct: 254 KSVKVWDVGTRTCVHTF---FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY-----DCPI 305 >5WJC-A nrPDB Length = 430 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 26/67 (38%), Positives = 37/67 (55%), Gaps = 10/67 (14%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ-------VRGKASFLYSL---PH 287 ++ H K + VA+NP D+ LATAS D+TV +WDLR + G +Y L PH Sbjct: 277 IQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPH 336 Query: 288 RHPVNAA 294 P+ A+ Sbjct: 337 DEPILAS 343 >5FVM-C nrPDB Length = 303 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 5/98 (5%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 HK VT +A W + ++S D T+K+WD+R S + H PVN P+ Sbjct: 74 HKGNVTSIAFQQENRW-MVSSSEDGTIKVWDVR----SPSVQRNYKHNAPVNEVAIHPNQ 128 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 L++ DQ IR++ + C L P + Q L+ Sbjct: 129 GELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLS 166 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 79/195 (40%), Gaps = 15/195 (7%) Query: 131 SKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNI 190 S+ G I +W+ P+ + + + +P N + + +G R+ D N Sbjct: 94 SEDGTIKVWDVR---SPSVQRNYKHNAPVNEVAIHP-NQGELISCDQDGNIRIWDLGENQ 149 Query: 191 LRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM----DGKEL---WNLRMHKK 243 + + N SL V++ M+V G+N GN + M D L + H K Sbjct: 150 CTNQLTPED-NTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTK 208 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 +T V L+ LAT S D T ++W++ + L H+ V FS D A L Sbjct: 209 YITRVLLSADVK-NLATCSADHTARVWNIEDNYQLETTLDG--HQRWVWDCAFSADSAYL 265 Query: 304 LTTDQKSEIRVYSAS 318 +T +R++ S Sbjct: 266 VTACSDHYVRLWDLS 280 >4XYI-A nrPDB Length = 430 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 27/70 (38%), Positives = 40/70 (57%), Gaps = 4/70 (5%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACF 296 ++ H++ V VA NP D+ LATAS D TV +WDLR++ + L++L H V + Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR---LHTLEGHEDEVYNVQW 333 Query: 297 SPDGARLLTT 306 SP +L T Sbjct: 334 SPHDEPILVT 343 >4V8M-A7 nrPDB Length = 318 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 108/249 (43%), Gaps = 30/249 (12%) Query: 111 DRRATSLAWHPTHPSTVAVGSKGG---------DIMLWNFGIKDKPTFIKGIGAGGSITG 161 DRR L H S VA+ + G + LWN +++ K +G + Sbjct: 60 DRR---LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWN--LQNGQCQYKFLGHTKDVLS 114 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS--SRMVVTG 219 + F+P N Q + + R+ + KG + + + W + S S + ++V+G Sbjct: 115 VAFSPDN-RQIVSGGRDNALRVWNVKGECMHTLSRGAHTD-WVSCVRFSPSLDAPVIVSG 172 Query: 220 --DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 277 DN+ V L G+ + +L+ H VT V ++P A++ D ++WDL +G Sbjct: 173 GWDNLVKVWDL-ATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLWDL--TKG 228 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 +A L + P+N CFSP+ + +K IR++ D + L P H+ + + Sbjct: 229 EA--LSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPE-HQGSKKI 284 Query: 338 TP--IKAAW 344 P + AW Sbjct: 285 VPECVSIAW 293 >6EMK-B nrPDB Length = 303 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H+ VT V+ W + T+S D T+K+WD+R S + H PVN P+ Sbjct: 74 HRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVR----SPSIPRNYKHNAPVNEVVIHPNQ 128 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 L++ D+ IR++ + C L P Q L+ Sbjct: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 Score = 31.2 bits (69), Expect = 0.98, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 13/103 (12%) Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 N AS ++ T+ + I R+ SSD ++ CS D +A R+ D+ L+ Sbjct: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA--RVWSIDDDFKLETTLD 247 Query: 230 MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 + +W+ +L TAS D V++WDL Sbjct: 248 GHQRWVWDCAFSADSA-----------YLVTASSDHYVRLWDL 279 >5OPT-p nrPDB Length = 318 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 93/214 (43%), Gaps = 17/214 (7%) Query: 151 KGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS 210 K +G + + F+P N Q + + R+ + KG L + W + S Sbjct: 104 KFLGHTKDVLSVTFSPDN-RQIVSGGRDNALRVWNVKGECLHTLGRGAHTD-WVSCVRFS 161 Query: 211 AS--SRMVVTG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQT 266 S + ++V+G DN+ V + G+ L +L+ H +T V ++P A++ D Sbjct: 162 PSLETPLIVSGGWDNLVKVWDI-ASGRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGV 219 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 ++WDL +G+A L + P+N CFSP+ + +K IR++ D + L Sbjct: 220 ARLWDL--TKGEA--LSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVEL 274 Query: 327 IPHPHRHFQHLTP--IKAAWHPRYNLIVVGRYPD 358 P + + TP + AW N + G Y D Sbjct: 275 APEAQQKSKK-TPECMSIAWSADGNTLYSG-YTD 306 Score = 36.2 bits (82), Expect = 0.026, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 43/79 (54%), Gaps = 4/79 (5%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 297 L H V+ VAL+ D F +AS D ++++W+L+ + FL H V + FS Sbjct: 63 LEGHSAFVSDVALSNNGD-FAVSASWDHSLRLWNLQTGVCQHKFL---GHTKDVLSVTFS 118 Query: 298 PDGARLLTTDQKSEIRVYS 316 PD ++++ + + +RV++ Sbjct: 119 PDNRQIVSGGRDNALRVWN 137 >3FM0-A nrPDB Length = 345 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 74/182 (40%), Gaps = 20/182 (10%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H++ V VA +PC + +LA+AS D T IW Q + H + V + ++P G Sbjct: 60 HQRTVRKVAWSPCGN-YLASASFDATTCIWKKNQDDFECVTTLE-GHENEVKSVAWAPSG 117 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360 L T + + V+ + D + + H Q + + WHP L+ Y D Sbjct: 118 NLLATCSRDKSVWVWEVDEED-EYECVSVLNSHTQDVKHV--VWHPSQELLASASYDD-- 172 Query: 361 FKSCTPYELRTIDVF-DGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIW 418 T+ ++ + + C + S + SL F+P G LAS + IW Sbjct: 173 ----------TVKLYREEEDDWVCCATLEGHESTVWSL-AFDPSGQRLASCSDDRTVRIW 221 Query: 419 SQ 420 Q Sbjct: 222 RQ 223 >5I2T-A nrPDB Length = 742 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 99/221 (44%), Gaps = 15/221 (6%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +SY IL++ FD SLA+ P S V S+ G I +W+ I S Sbjct: 360 ESY-ILKQQGHFDS-TNSLAYSP-DGSRVVTASEDGKIKVWD--ITSGFCLATFEEHTSS 414 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVV 217 +T ++F F +SS++GT R D + R F ++ I F L V S +V Sbjct: 415 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCLAVDPSGEVVC 471 Query: 218 TG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 G DN + G+ L L H+ V+ ++ + + LA+AS D+T++IW + Sbjct: 472 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQE-NSVLASASWDKTIRIW---SI 527 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 G++ + + V A PDG + + K +I +++ Sbjct: 528 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFN 568 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 14/194 (7%) Query: 212 SSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270 ++R++ G G L ++ D + L M + V V++N +W +S + ++ Sbjct: 296 ATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY 355 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 + + ++ L H N+ +SPDG+R++T + +I+V WD G Sbjct: 356 EWQ---SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV-----WDITSGFCLAT 407 Query: 331 HRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG-KMMCQLYDP 389 +H + + A + ++ D ++ R F G + C DP Sbjct: 408 FE--EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP 465 Query: 390 ESSGI--SSLNEFN 401 + SL+ F+ Sbjct: 466 SGEVVCAGSLDNFD 479 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 15/140 (10%) Query: 205 CSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWF-LATASV 263 ++D++ ++++ D G IL+N + + + K+K + V +P F LA+ Sbjct: 84 AAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRF 143 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF--------SPDGARLLTTDQKSEIRVY 315 Q K D+ + R A F+ RH V+A F S D +LTT + +++ Sbjct: 144 LQIWKTPDVNKDRQFAPFV-----RHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIW 198 Query: 316 SASQWDCPLGLIP-HPHRHF 334 S + L + HR + Sbjct: 199 SVDSEEKNLAATTFNGHRDY 218 >5WLC-LO nrPDB Length = 923 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 99/221 (44%), Gaps = 15/221 (6%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +SY IL++ FD SLA+ P S V S+ G I +W+ I S Sbjct: 335 ESY-ILKQQGHFDS-TNSLAYSP-DGSRVVTASEDGKIKVWD--ITSGFCLATFEEHTSS 389 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVV 217 +T ++F F +SS++GT R D + R F ++ I F L V S +V Sbjct: 390 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCLAVDPSGEVVC 446 Query: 218 TG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 G DN + G+ L L H+ V+ ++ + + LA+AS D+T++IW + Sbjct: 447 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQE-NSVLASASWDKTIRIW---SI 502 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 G++ + + V A PDG + + K +I +++ Sbjct: 503 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFN 543 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 14/194 (7%) Query: 212 SSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270 ++R++ G G L ++ D + L M + V V++N +W +S + ++ Sbjct: 271 ATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY 330 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 + + ++ L H N+ +SPDG+R++T + +I+V WD G Sbjct: 331 EWQ---SESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV-----WDITSGFCLAT 382 Query: 331 HRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG-KMMCQLYDP 389 +H + + A + ++ D ++ R F G + C DP Sbjct: 383 FE--EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP 440 Query: 390 ESSGI--SSLNEFN 401 + SL+ F+ Sbjct: 441 SGEVVCAGSLDNFD 454 Score = 31.6 bits (70), Expect = 0.66, Method: Compositional matrix adjust. Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 15/140 (10%) Query: 205 CSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWF-LATASV 263 ++D++ ++++ D G IL+N + + + K+K + V +P F LA+ Sbjct: 59 AAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRF 118 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF--------SPDGARLLTTDQKSEIRVY 315 Q K D+ + R A F+ RH V+A F S D +LTT + +++ Sbjct: 119 LQIWKTPDVNKDRQFAPFV-----RHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIW 173 Query: 316 SASQWDCPLGLIP-HPHRHF 334 S + L + HR + Sbjct: 174 SVDSEEKNLAATTFNGHRDY 193 >2H9P-A nrPDB Length = 329 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 67/134 (50%), Gaps = 9/134 (6%) Query: 210 SASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 268 S+ S ++V+ + + + ++ GK L L+ H V NP + + + S D++V+ Sbjct: 91 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVR 149 Query: 269 IWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 IWD++ GK L +LP H PV+A F+ DG+ ++++ R++ + C LI Sbjct: 150 IWDVKT--GKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 205 Query: 328 --PHPHRHFQHLTP 339 +P F +P Sbjct: 206 DDDNPPVSFVKFSP 219 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 37/169 (21%), Positives = 71/169 (42%), Gaps = 8/169 (4%) Query: 168 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 ++N ++S + T ++ D G L+ N FC + + S ++V+G +V Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS--NYVFC-CNFNPQSNLIVSGSFDESVR 149 Query: 227 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 + ++ GK L L H V+ V N + ++S D +IWD G+ Sbjct: 150 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWD--TASGQCLKTLID 206 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHF 334 PV+ FSP+G +L + ++++ S+ C H + + Sbjct: 207 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 255 >5M25-A nrPDB Length = 434 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 67/134 (50%), Gaps = 9/134 (6%) Query: 210 SASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 268 S+ S ++V+ + + + ++ GK L L+ H V NP + + + S D++V+ Sbjct: 196 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVR 254 Query: 269 IWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 IWD++ GK L +LP H PV+A F+ DG+ ++++ R++ + C LI Sbjct: 255 IWDVKT--GKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 310 Query: 328 --PHPHRHFQHLTP 339 +P F +P Sbjct: 311 DDDNPPVSFVKFSP 324 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 37/169 (21%), Positives = 71/169 (42%), Gaps = 8/169 (4%) Query: 168 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 ++N ++S + T ++ D G L+ N FC + + S ++V+G +V Sbjct: 198 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS--NYVFC-CNFNPQSNLIVSGSFDESVR 254 Query: 227 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 + ++ GK L L H V+ V N + ++S D +IWD G+ Sbjct: 255 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWD--TASGQCLKTLID 311 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHF 334 PV+ FSP+G +L + ++++ S+ C H + + Sbjct: 312 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 360 >6HHQ-h nrPDB Length = 319 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 62/143 (43%), Gaps = 17/143 (11%) Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPC-----CDWFLAT 260 S+D+ + M+++G + + + G+ L L H V+ V + P + + Sbjct: 112 SVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIIS 171 Query: 261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV------ 314 A D+ VK W+L Q + +A F + H +N SPDG + + + EI + Sbjct: 172 AGNDKMVKAWNLNQFQIEADF---IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAK 228 Query: 315 ---YSASQWDCPLGLIPHPHRHF 334 Y+ S D L P+R++ Sbjct: 229 KAMYTLSAQDEVFSLAFSPNRYW 251 >5Y1U-A nrPDB Length = 456 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 37/70 (52%), Gaps = 2/70 (2%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 296 ++ H +V ++ NP ++ LAT S D+TV +WDLR ++ K S H+ + + Sbjct: 299 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES--HKDEIFQVQW 356 Query: 297 SPDGARLLTT 306 SP +L + Sbjct: 357 SPHNETILAS 366 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 235 LWNLR----------MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 LW+LR HK ++ V +P + LA++ D+ + +WDL ++ + S Sbjct: 331 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 386 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 22/38 (57%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 LR H+K+ ++ NP L +AS D T+ +WD+ V Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAV 241 >6MZM-G nrPDB Length = 800 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 13/175 (7%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G + G F+P + N +SS +GT RL + V +W S Sbjct: 541 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYG 597 Query: 214 RMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 V+G + L D + L H V +P ++ +AT S D+TV++WD+ Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSADRTVRLWDV 656 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 + G +++ H+ P+++ FSP+G L T + + WD GL+ Sbjct: 657 --LNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLL-----WDIGHGLM 703 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 7/111 (6%) Query: 163 KFNPLNTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDN 221 +F+P N+N S + T RL D GN +R+F SL S + R + TG Sbjct: 634 RFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP---IHSLTFSPNGRFLATGAT 689 Query: 222 VGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 G V+L ++ G + L+ H V + + + LA+ S+D TV++WD Sbjct: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 739 >6F3T-A nrPDB Length = 608 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 13/175 (7%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G + G F+P + N +SS +GT RL + V +W S Sbjct: 349 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPYG 405 Query: 214 RMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 V+G + L D + L H V +P + ++AT S D+TV++WD+ Sbjct: 406 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-YVATGSADRTVRLWDV 464 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 + G +++ H+ P+++ FSP+G L T + + WD GL+ Sbjct: 465 --LNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLL-----WDIGHGLM 511 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 7/120 (5%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSAS 212 G + +F+P N+N S + T RL D GN +R+F SL S + Sbjct: 433 GHLADVNCTRFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP---IHSLTFSPN 488 Query: 213 SRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 R + TG G V+L ++ G + L+ H V + + + LA+ S+D TV++WD Sbjct: 489 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 547 >3C9C-A nrPDB Length = 432 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 2/66 (3%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H +V ++ NP ++ LAT S D+TV +WDLR ++ K S H+ + +SP Sbjct: 278 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES--HKDEIFQVQWSPHN 335 Query: 301 ARLLTT 306 +L + Sbjct: 336 ETILAS 341 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 LR H+K+ ++ NP + +L +AS D T+ +WD+ Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN 214 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 235 LWNLR----------MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 LW+LR HK ++ V +P + LA++ D+ + +WDL ++ + S Sbjct: 306 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQS 361 >3CFV-B nrPDB Length = 414 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 2/66 (3%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H +V ++ NP ++ LAT S D+TV +WDLR ++ K S H+ + +SP Sbjct: 274 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFES--HKDEIFQVHWSPHN 331 Query: 301 ARLLTT 306 +L + Sbjct: 332 ETILAS 337 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 235 LWNLR----------MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 LW+LR HK ++ V +P + LA++ D+ + +WDL ++ + S Sbjct: 302 LWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQS 357 >2HES-X nrPDB Length = 330 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 63/160 (39%), Gaps = 20/160 (12%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-----PHRHPVNAAC 295 HKK + VA P LA S D TV IW ++ +F L H + V Sbjct: 57 HKKAIRSVAWRPHTS-LLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 296 FSPDGARLLTTDQKSEIRVY----SASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI 351 +S DG L T + + ++ S +++C L H + +H+ WHP L+ Sbjct: 115 WSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHS-QDVKHVI-----WHPSEALL 168 Query: 352 VVGRYPDPNFKSCTPY--ELRTIDVFDGNSGKMMCQLYDP 389 Y D + Y + + V +G+ G + +D Sbjct: 169 ASSSYDDT-VRIWKDYDDDWECVAVLNGHEGTVWSSDFDK 207 >5NNZ-B nrPDB Length = 415 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 66/304 (21%), Positives = 116/304 (38%), Gaps = 69/304 (22%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG 154 L+TL+ +R + A F+ +P + +A GS LW+ ++ + G Sbjct: 127 LNTLEGHRNVVYAIAFN--------NP-YGDKIATGSFDKTCKLWS--VETGKCYHTFRG 175 Query: 155 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFA----SSDTINIWFCSLDVS 210 I L FNP +T SM+ T +L D + N V+ S++ I SL + Sbjct: 176 HTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQ-NGEEVYTLRGHSAEII-----SLSFN 228 Query: 211 ASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 S ++TG V++ + D G+++ L H +++ + N C L T S+D+T K+ Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMDKTCKL 287 Query: 270 WDLRQVRGKASF-----------------------------LYSLP----------HRHP 290 WD + A+ ++S H Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNL 350 ++ F+P G LLT R++ A C L H F A++ + N+ Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS------CAFNYKGNI 401 Query: 351 IVVG 354 ++ G Sbjct: 402 VITG 405 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 80/191 (41%), Gaps = 30/191 (15%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACF 296 L+ H +T+VALN F+ T S D+T K+WD L +L HR+ V A F Sbjct: 88 LKAHILPLTNVALNKSGSCFI-TGSYDRTCKLWD----TASGEELNTLEGHRNVVYAIAF 142 Query: 297 -SPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLIVVG 354 +P G ++ T +++S C H H I +++P+ L+ G Sbjct: 143 NNPYGDKIATGSFDKTCKLWSVETGKC-------YHTFRGHTAEIVCLSFNPQSTLVATG 195 Query: 355 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGD-TLASAMGY 413 T ++D +G+ + L S+ I SL+ FN GD + + + Sbjct: 196 SMD------------TTAKLWDIQNGEEVYTLR-GHSAEIISLS-FNTSGDRIITGSFDH 241 Query: 414 HILIWSQEEAR 424 +++W + R Sbjct: 242 TVVVWDADTGR 252 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 8/94 (8%) Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPV 291 G+EL L H+ V +A N +AT S D+T K+W + + +F H + Sbjct: 124 GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF---RGHTAEI 180 Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 F+P + T + +A WD G Sbjct: 181 VCLSFNPQSTLVATGSMDT-----TAKLWDIQNG 209 >5CXC-A nrPDB Length = 510 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 5/122 (4%) Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVT 218 T F+P + Y++S + T R D G ++ + + +S ++ Sbjct: 316 TAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAA 375 Query: 219 GDNVGNVILLNMDGKE----LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 274 G + ++ +++ + LR H KV ++ +P ++ L + S D T ++WDLR Sbjct: 376 GTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Query: 275 VR 276 VR Sbjct: 436 VR 437 >6QX9-4B nrPDB Length = 522 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 7/91 (7%) Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHP 290 G+ + L H K++ + +P + +AT S D T K+WDLRQ R +Y++P H++ Sbjct: 397 GRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRR----CVYTIPAHQNL 451 Query: 291 VNAACFSP-DGARLLTTDQKSEIRVYSASQW 320 V F P G LLT + ++++ W Sbjct: 452 VTGVKFEPIHGNFLLTGAYDNTAKIWTHPGW 482 >3JB9-g nrPDB Length = 558 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 42/94 (44%), Gaps = 9/94 (9%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPV 291 K ++ + H K ++ + P L + S+D +KIW++ R S L + H P+ Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDR---SLLRTFQGHARPI 313 Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 FS DG L+T I++ WD LG Sbjct: 314 RDLSFSQDGRSFLSTSFDKTIKL-----WDTELG 342 >5WBU-D nrPDB Length = 328 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 3/74 (4%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 ++ T D T +IWDLR + ++ + P+N C P+ A L+ DQ I ++ Sbjct: 101 WMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAPINCVCLHPNQAELIVGDQSGAIHIWD 158 Query: 317 ASQWDCPLGLIPHP 330 D LIP P Sbjct: 159 LKT-DHNEQLIPEP 171 >5OV3-A nrPDB Length = 381 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 12/92 (13%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 LA D + IWD RG A + + H HPV + C+S DG +L++ + + Sbjct: 39 LLAVGCNDGRIVIWDFL-TRGIAKIISA--HIHPVCSLCWSRDGHKLVSASTDNIV---- 91 Query: 317 ASQWDCPLGLIPHPHRHFQHLTPI-KAAWHPR 347 SQWD G + F+ +PI K +HPR Sbjct: 92 -SQWDVLSG---DCDQRFRFPSPILKVQYHPR 119 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 87/212 (41%), Gaps = 40/212 (18%) Query: 159 ITGLKFNPLNTNQFYASSMEGT---TRLQDFKGNILRVFASSDTINIWFCSLDVSAS--- 212 I ++++P + N+ M+ L D K +L V SD L+V AS Sbjct: 111 ILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSD--------LNVVASFDR 162 Query: 213 -SRMVVTGDNVGNVILLNMDGKELW-NLRMHKK-------KVTHVALNPCCDWFLATASV 263 + TG+ G +++L D ++L + R+ K A C + + TA Sbjct: 163 RGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSC-FLINTA-- 219 Query: 264 DQTVKIWDLRQVR--GK------ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 D+ ++++D R++ G+ L L +R P CFS DG ++ R + Sbjct: 220 DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVA----GSARQH 275 Query: 316 SASQWDCPLG-LIPHPHRHFQHLTPIKAAWHP 346 + W+ +G L+ H L + AWHP Sbjct: 276 ALYIWEKSIGNLVKILHGTRGELL-LDVAWHP 306 >4LG8-A nrPDB Length = 354 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 5/93 (5%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 296 N H +T +A + ++LATA+ D +VK+WDLR+++ + L + V + F Sbjct: 237 NFPGHSGPITSIAFSEN-GYYLATAADDSSVKLWDLRKLKNFKTL--QLDNNFEVKSLIF 293 Query: 297 SPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 G L +++++Y QW L H Sbjct: 294 DQSGTYLAL--GGTDVQIYICKQWTEILHFTEH 324 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 36/63 (57%), Gaps = 2/63 (3%) Query: 211 ASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 + + ++TG NV++ + ++ L L+ H KKVT V +P D + +AS D T++I Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRI 140 Query: 270 WDL 272 W + Sbjct: 141 WSV 143 >5UZ7-B nrPDB Length = 351 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/146 (21%), Positives = 60/146 (41%), Gaps = 13/146 (8%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H V ++L P F++ A D + K+WD+R+ + +F H +NA CF P+G Sbjct: 194 HTGDVMSLSLAPDTRLFVSGA-CDASAKLWDVREGMCRQTFT---GHESDINAICFFPNG 249 Query: 301 ARLLTTDQKSEIRVYS--ASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 T + R++ A Q L+ + H + + I + + +++ Y D Sbjct: 250 NAFATGSDDATCRLFDLRADQ-----ELMTYSHDNI--ICGITSVSFSKSGRLLLAGYDD 302 Query: 359 PNFKSCTPYELRTIDVFDGNSGKMMC 384 N + V G+ ++ C Sbjct: 303 FNCNVWDALKADRAGVLAGHDNRVSC 328 >6HQA-B nrPDB Length = 722 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 67/169 (39%), Gaps = 19/169 (11%) Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDN 221 LK +P N +++G+ RL G + V S D + CS D + Sbjct: 428 LKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKT----------- 476 Query: 222 VGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 V L ++D L + + H V V +P +F ATAS DQT ++W + Sbjct: 477 ---VRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYF-ATASHDQTARLWSCDHIYPLRI 532 Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 F H + V+ F P+ L T R++ ++ +C + H Sbjct: 533 F---AGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGH 578 >4BTS-AR nrPDB Length = 343 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 44/80 (55%), Gaps = 6/80 (7%) Query: 238 LRMHKKKVTHVALN-PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 296 L H V+ +AL+ C F ++S D+T+++WDLR F+ H+ V + F Sbjct: 72 LTGHNHFVSDLALSQENC--FAISSSWDKTLRLWDLRTGTTYKRFV---GHQSEVYSVAF 126 Query: 297 SPDGARLLTTDQKSEIRVYS 316 SPD ++L+ + EI++++ Sbjct: 127 SPDNRQILSAGAEREIKLWN 146 >5BJS-A nrPDB Length = 605 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 10/126 (7%) Query: 215 MVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 ++ N GNV + N+ +GK L H + +A +P + +A+AS D T++IW L Sbjct: 150 LLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLA 209 Query: 274 QVRGK---ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW-----DCPLG 325 K L H + + + F +G +L+ I +++ ++ + P+ Sbjct: 210 PEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPI- 268 Query: 326 LIPHPH 331 +I +PH Sbjct: 269 VIYYPH 274 >5Z56-q nrPDB Length = 504 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 5/93 (5%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 296 N H +T +A + ++LATA+ D +VK+WDLR+++ + L + V + F Sbjct: 387 NFPGHSGPITSIAFSEN-GYYLATAADDSSVKLWDLRKLKNFKTL--QLDNNFEVKSLIF 443 Query: 297 SPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 G L +++++Y QW L H Sbjct: 444 DQSGTYLALGG--TDVQIYICKQWTEILHFTEH 474 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 40/71 (56%), Gaps = 3/71 (4%) Query: 204 FCSLDVSAS-SRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATA 261 +LD+ S + ++TG NV++ + ++ L L+ H KKVT V +P D + +A Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQD-LVFSA 282 Query: 262 SVDQTVKIWDL 272 S D T++IW + Sbjct: 283 SPDATIRIWSV 293 >6Q8F-A nrPDB Length = 514 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 61/149 (40%), Gaps = 6/149 (4%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIG--AGGSIT--GLKFNPLNTNQFYASSMEGTTR 182 + S G + +WN + K +G AG IT + P N F + T Sbjct: 365 IISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVV 424 Query: 183 LQDFKGNILRVFASSDTINIWFCSLDVSASSR-MVVTGDNVGNVILLNMDGKELWNLRMH 241 + + +G I+R F+S F +S + G++ + GK L +H Sbjct: 425 IMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVH 484 Query: 242 KKKVTHVALNPCCDWFLATASVDQTVKIW 270 +K V +A +P + +AT S D +K+W Sbjct: 485 EKDVIGIAHHPHQN-LIATYSEDGLLKLW 512 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 5/71 (7%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYS-----LPHRHPVNAACFSPDGARLLTTDQKSE 311 +L T SVD +++W+ + + Y + V CFS D L T Q + Sbjct: 229 YLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGK 288 Query: 312 IRVYSASQWDC 322 I+V+ C Sbjct: 289 IKVWKIQSGQC 299 >5FL8-q nrPDB Length = 515 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 6/87 (6%) Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRH 289 DGK + R H V VA + C L + S D T+K+WD+R + LP H+ Sbjct: 433 DGKFISTFRGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWDVRTRK----LSVDLPGHKD 487 Query: 290 PVNAACFSPDGARLLTTDQKSEIRVYS 316 V +S DG R+ + + +R+++ Sbjct: 488 EVYTVDWSVDGKRVCSGGKDKMVRLWT 514 Score = 31.2 bits (69), Expect = 0.92, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 34/218 (15%) Query: 115 TSLAWHPTH---PST---VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168 TSL+W P H P + +A SK G I +W+ + G S++ +K+ Sbjct: 233 TSLSWEPIHLVKPGSKPRLASSSKDGTIKIWD--TVSRVCQYTMSGHTNSVSCVKWG--G 288 Query: 169 TNQFYASSMEGTTRLQDFKG-----NILRVFASSDTINIWFCSLDVSASSRMVVTG-DNV 222 Y+ S + T R+ D NIL+ A W L +S + + D+ Sbjct: 289 QGLLYSGSHDRTVRVWDINSQGRCINILKSHAH------WVNHLSLSTDYALRIGAFDHT 342 Query: 223 GN--VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD-LRQVRGKA 279 G K L N KK N + + TAS D T+ +W+ L+ + A Sbjct: 343 GKKPSTPEEAQKKALENYEKICKK------NGNSEEMMVTASDDYTMFLWNPLKSTKPIA 396 Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 H+ VN FSPDG +++ + I+++ Sbjct: 397 RMT---GHQKLVNHVAFSPDGRYIVSASFDNSIKLWDG 431 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 10/83 (12%) Query: 211 ASSRMVV-TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 SSRMV GDN + + + L+ H V V+ +P + +AT S+D T+++ Sbjct: 155 TSSRMVTGAGDNTARIWDCDTQ-TPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRL 212 Query: 270 WDLRQ-------VRGKASFLYSL 285 WD + +RG + ++ SL Sbjct: 213 WDPKSGQCLGDALRGHSKWITSL 235 >4V7E-Bg nrPDB Length = 380 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 34/75 (45%), Gaps = 2/75 (2%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H V +++N + S D TV++WDLR + +A Y H +N+ F PDG Sbjct: 204 HTADVLSLSINSLNANMFISGSCDTTVRLWDLR-ITSRAVRTYH-GHEGDINSVKFFPDG 261 Query: 301 ARLLTTDQKSEIRVY 315 R T R++ Sbjct: 262 QRFGTGSDDGTCRLF 276 >1VYH-C nrPDB Length = 410 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 37/174 (21%), Positives = 76/174 (43%), Gaps = 8/174 (4%) Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 +T + F+P+ + AS + T ++ D++ T ++ S D S +++ + Sbjct: 111 VTRVIFHPVFSVMVSASE-DATIKVWDYETGDFERTLKGHTDSVQDISFD--HSGKLLAS 167 Query: 219 GDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 277 + L + G E + + H V+ V++ P D + +AS D+T+K+W+++ Sbjct: 168 CSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGD-HIVSASRDKTIKMWEVQTGYC 226 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 +F HR V + DG + + +RV+ + +C L H H Sbjct: 227 VKTFT---GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRH 277 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 6/99 (6%) Query: 234 ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVN 292 E + L H+ VT V +P + +AS D T+K+WD F +L H V Sbjct: 100 EKYALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYET----GDFERTLKGHTDSVQ 154 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 F G L + I+++ ++C + H H Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 10/17 (58%), Positives = 14/17 (82%) Query: 257 FLATASVDQTVKIWDLR 273 ++ T SVDQTVK+W+ R Sbjct: 394 YVVTGSVDQTVKVWECR 410 >5Y88-O nrPDB Length = 451 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 42/199 (21%), Positives = 84/199 (42%), Gaps = 21/199 (10%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G + + +P++ F S + T ++ D L+ + + + DV+ S Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTV----RDVAVSD 192 Query: 214 R----MVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 R V+ D L + + + + H V V+++P D +ATA D +K+ Sbjct: 193 RHPYLFSVSEDKTVKCWDLEKN-QIIRDYYGHLSGVRTVSIHPTLD-LIATAGRDSVIKL 250 Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 WD+R + + + H+ P+N +P +++++ + +R+ WD G Sbjct: 251 WDMRT---RIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRL-----WDVVAGKTMK 302 Query: 330 PHRHFQHLTPIKA-AWHPR 347 H H ++A A HP+ Sbjct: 303 VLTH--HKRSVRATALHPK 319 >5MZH-A nrPDB Length = 452 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 67/258 (25%) Query: 116 SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYAS 175 ++A++ + + GS LW+ +KG I L FNP +T Sbjct: 141 AIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQT--EIVCLSFNPQST-IIATG 197 Query: 176 SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL 235 SM+ T +L D + R + I SL + ++VTG + D + L Sbjct: 198 SMDNTAKLWDVETGQERATLAGHRAEI--VSLGFNTGGDLIVTGS-------FDHDSR-L 247 Query: 236 WNLRM---------HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR---------- 276 W++R H+ +V+ N + + S+D T ++WD+R R Sbjct: 248 WDVRTGQCVHVLSGHRGEVSSTQFNYA-GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD 306 Query: 277 --------------------GKASFLYSLP---------HRHPVNAACFSPDGARLLTTD 307 G A ++L H ++ F+P G RL+T Sbjct: 307 EVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITAS 366 Query: 308 QKSEIRVYSASQWDCPLG 325 R+ WDC G Sbjct: 367 SDKTCRL-----WDCDTG 379 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPV 291 G+ + L+ H+ ++ ++ NP +AT S+D T K+WD+ + +A+ HR + Sbjct: 169 GQLYYTLKGHQTEIVCLSFNPQST-IIATGSMDNTAKLWDVETGQERATL---AGHRAEI 224 Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 + F+ G ++T + R++ C L H Sbjct: 225 VSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGH 262 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 73/170 (42%), Gaps = 18/170 (10%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G ++ +FN T + S++ T+RL D + T + + D +A + Sbjct: 261 GHRGEVSSTQFNYAGT-LVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFD-AAGT 318 Query: 214 RMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD-- 271 +MV + + + G L H+ +++ VA NP L TAS D+T ++WD Sbjct: 319 KMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTR-LITASSDKTCRLWDCD 377 Query: 272 ----LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 L+ + G H + + F+ +G ++T + + R++ A Sbjct: 378 TGECLQVLEG---------HTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 10/95 (10%) Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHP 290 G+E++ L HK V +A N + T S D+T K+WD Y+L H+ Sbjct: 126 GEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAY----TGQLYYTLKGHQTE 181 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 + F+P + T + +A WD G Sbjct: 182 IVCLSFNPQSTIIATGSMDN-----TAKLWDVETG 211 >6QX9-5O nrPDB Length = 357 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 44/194 (22%), Positives = 83/194 (42%), Gaps = 46/194 (23%) Query: 123 HPSTVAVGSKGGD--IMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS--- 176 HP+ + S G D I+LWN +G D +KG G++ L +N + F AS+ Sbjct: 75 HPNGSTLASAGFDRLILLWNVYGDCDNYATLKG--HSGAVMELHYNTDGSMLFSASTDKT 132 Query: 177 -----MEGTTRLQDFKGNI--------------LRVFASSD-TINIW------------- 203 E R++ KG+ L S D T+ +W Sbjct: 133 VAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQN 192 Query: 204 ---FCSLDVSASSRMVVTGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLA 259 ++ + +S +++G ++ + ++ +L + +R H VT ++L+ + L+ Sbjct: 193 TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLS 252 Query: 260 TASVDQTVKIWDLR 273 A +D TV++WD+R Sbjct: 253 NA-MDNTVRVWDVR 265 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/63 (25%), Positives = 33/63 (52%), Gaps = 4/63 (6%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 + T S D TVK+WD+R K + + + + + V A F+ ++++ ++I+V+ Sbjct: 166 LVCTGSDDGTVKLWDIR----KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD 221 Query: 317 ASQ 319 Q Sbjct: 222 LRQ 224 >3DW8-B nrPDB Length = 447 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 75/319 (23%), Positives = 124/319 (38%), Gaps = 68/319 (21%) Query: 79 GRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSK-----G 133 GR P+ L+ +D ++ +A+P RR + A H H +++++ S Sbjct: 141 GRYRDPTTVTTLRVPVFRPMD---LMVEASP--RRIFANA-HTYHINSISINSDYETYLS 194 Query: 134 GD---IMLWNFGIKDKPTFIKGIGAGGS------ITGLKFNPLNTNQFYASSMEGTTRLQ 184 D I LW+ I D+ I I IT +F+P + N F SS +GT RL Sbjct: 195 ADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLC 254 Query: 185 DFKGNIL-----RVFAS-SDTINIWFCSLDVSA--------SSRMVVTGDNVG-NVILLN 229 D + + L ++F D N F S +S+ S R ++T D + V LN Sbjct: 255 DMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLN 314 Query: 230 MDGKELWNLRMH---KKKVTHVALNPC------CDW-----FLATASVDQTVKIWDLRQV 275 M+ + + ++H + K+ + N C C W + T S + +++D R Sbjct: 315 MENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFD-RNT 373 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQ 335 + + S + P P +K EI V S ++ Sbjct: 374 KRDITLEASRENNKP--RTVLKPRKVCASGKRKKDEISVDSLD-----------FNKKIL 420 Query: 336 HLTPIKAAWHPRYNLIVVG 354 H AWHP+ N+I V Sbjct: 421 H-----TAWHPKENIIAVA 434 >2YNP-A nrPDB Length = 604 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 54/253 (21%), Positives = 94/253 (37%), Gaps = 32/253 (12%) Query: 113 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 172 R + +HPT P V G + LWN+ + + I+ + P+ +F Sbjct: 15 RVKGIDFHPTEP-WVLTTLYSGRVELWNYETQVEVRSIQ----------VTETPVRAGKF 63 Query: 173 YASSMEGTTRLQDFKGNILRVFASSDTINI-----WFCSLDVSASSRMVVTGDNVGNVIL 227 A DF+ + ++ + S+ V + V++G + V L Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 228 LNMDGKELWNLRM----HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 N + W L H+ V VA NP A+ +D+TVK+W L Q +F Sbjct: 124 WNWENN--WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ--STPNFTL 179 Query: 284 SLPHRHPVNAACFS--PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 + VN + PD ++T I+++ C L H +++ Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL----EGHMSNVS--F 233 Query: 342 AAWHPRYNLIVVG 354 A +HP +I+ G Sbjct: 234 AVFHPTLPIIISG 246 >5WYK-BB nrPDB Length = 943 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Query: 206 SLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVD 264 S+D+S S+M++T N+ + +D G +L H+ + +V P F + S D Sbjct: 578 SIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFS-CSKD 636 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 VK WD + LY+ H+ V A + DG ++++ IR++ ++ Sbjct: 637 AVVKYWDGEKFECIQK-LYA--HQSEVWALAVATDGGFVVSSSHDHSIRIWEETE 688 Score = 35.8 bits (81), Expect = 0.037, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 26/155 (16%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 186 +AVG G I +W+ + K + G +IT L+F+ T + + S + + D Sbjct: 94 LAVGYADGVIKVWD--LMSKTVLLNFNGHKAAITLLQFDGTGT-RLISGSKDSNIIVWDL 150 Query: 187 KGNI--LRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK-ELWNLRMHKK 243 G + ++ + D+I ++C G++ +I + DG +LW+L+ H+ Sbjct: 151 VGEVGLYKLRSHKDSITGFWCQ------------GEDW--LISTSKDGMIKLWDLKTHQC 196 Query: 244 KVTHVALNPCC------DWFLATASVDQTVKIWDL 272 TH+A C D L T D VKIW L Sbjct: 197 IETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKL 231 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 3/68 (4%) Query: 207 LDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265 L + +++G N+I+ ++ G+ L+ LR HK +T DW ++T S D Sbjct: 127 LQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGE-DWLIST-SKDG 184 Query: 266 TVKIWDLR 273 +K+WDL+ Sbjct: 185 MIKLWDLK 192 >3MKQ-A nrPDB Length = 814 Score = 35.0 bits (79), Expect = 0.058, Method: Compositional matrix adjust. Identities = 53/253 (20%), Positives = 94/253 (37%), Gaps = 32/253 (12%) Query: 113 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 172 R + +HPT P V G + +WN+ + + I+ + P+ +F Sbjct: 15 RVKGIDFHPTEP-WVLTTLYSGRVEIWNYETQVEVRSIQ----------VTETPVRAGKF 63 Query: 173 YASSMEGTTRLQDFKGNILRVFASSDTINI-----WFCSLDVSASSRMVVTGDNVGNVIL 227 A DF+ + ++ + S+ V + V++G + V L Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 228 LNMDGKELWNLRM----HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 N + W L H+ V VA NP A+ +D+TVK+W L Q +F Sbjct: 124 WNWENN--WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ--STPNFTL 179 Query: 284 SLPHRHPVNAACFS--PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 + VN + PD ++T I+++ C L H +++ Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL----EGHMSNVSF-- 233 Query: 342 AAWHPRYNLIVVG 354 A +HP +I+ G Sbjct: 234 AVFHPTLPIIISG 246 >5NZU-C nrPDB Length = 905 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 58/264 (21%), Positives = 105/264 (39%), Gaps = 35/264 (13%) Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 I +K R S+ HPT P +A G + +WN + T +K + L Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLA-SLYNGSVCVWN---HETQTLVKTF----EVCDL 58 Query: 163 KFNPLNTNQFYASSMEGTTRLQD-----FKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 P+ +F A T D F N L + + + + V + ++ Sbjct: 59 ---PVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFIL 115 Query: 218 TGDNVGNVILLNMDGKELWN----LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 T + + L + D K W+ H V + +NP + A+AS+D+T+K+W L Sbjct: 116 TSSDDMLIKLWDWDKK--WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL- 172 Query: 274 QVRGKASFLYSLP-HRHPVNAACFSPDGAR--LLTTDQKSEIRVYSASQWDCPLGLIPHP 330 G +S ++L H VN + G + L++ ++++ C L Sbjct: 173 ---GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL---- 225 Query: 331 HRHFQHLTPIKAAWHPRYNLIVVG 354 H Q+++ A++HP +I+ G Sbjct: 226 EGHAQNVSC--ASFHPELPIIITG 247 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 48/233 (20%), Positives = 86/233 (36%), Gaps = 68/233 (29%) Query: 100 SYRILQKAAPFDRRAT---SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG 156 +Y L++ F+ + +A HPT P + S I LW++ DK + G Sbjct: 85 NYNTLERVHMFEAHSDYIRCIAVHPTQP-FILTSSDDMLIKLWDW---DKKWSCSQVFEG 140 Query: 157 GS--ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 214 + + + NP + NQF ++S++ TI +W S+S Sbjct: 141 HTHYVMQIVINPKDNNQFASASLD-------------------RTIKVWQLG---SSSPN 178 Query: 215 MVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWF-------LATASVDQTV 267 + G H+K V C D++ L + + D+ V Sbjct: 179 FTLEG---------------------HEKGVN------CIDYYSGGDKPYLISGADDRLV 211 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 320 KIWD + K H V+ A F P+ ++T + +R++ +S + Sbjct: 212 KIWDYQ---NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTY 261 >2AQ5-A nrPDB Length = 402 Score = 35.0 bits (79), Expect = 0.065, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 38/80 (47%), Gaps = 5/80 (6%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP--VNAA 294 L H K+V VA +P L +A D + +WD V A+ L P HP + + Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWD---VGTGAAVLTLGPDVHPDTIYSV 182 Query: 295 CFSPDGARLLTTDQKSEIRV 314 +S DGA + T+ + +RV Sbjct: 183 DWSRDGALICTSCRDKRVRV 202 >3JB9-S nrPDB Length = 488 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 8/128 (6%) Query: 199 TINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWF 257 T+ SL V + V G G + G EL H V + W Sbjct: 331 TVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWL 390 Query: 258 LATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS---EIRV 314 + T + D + IWDLR K+ + +P + V A L+++D ++ I V Sbjct: 391 VVTTNDDSDIFIWDLR----KSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYV 446 Query: 315 YSASQWDC 322 S+ W C Sbjct: 447 KSSKSWRC 454 >5OQL-d nrPDB Length = 446 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 78/196 (39%), Gaps = 33/196 (16%) Query: 136 IMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK----GNI 190 I LW+ + T I GG T L F+ + N F ASS +G R+ D + G Sbjct: 132 IKLWDPYASPSNTTPIATWQEGGPYTSLSFHR-SANTFAASSGQGCIRIWDLEHSTAGQA 190 Query: 191 LRVFASSDTI-NIWFCSLDVS-----ASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKK 244 ++ + DTI ++ F ++ S A+ R ++ D N+ ++ K Sbjct: 191 IQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVI--------------KT 236 Query: 245 VTHVA-----LNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPD 299 V H A NP LA AS D + I+D R + H V FSP Sbjct: 237 VLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNF--DKALNIQKGHVAAVMDVEFSPT 294 Query: 300 GARLLTTDQKSEIRVY 315 G L++ IR++ Sbjct: 295 GEELVSGSYDRTIRLW 310 >6BX3-B nrPDB Length = 412 Score = 34.7 bits (78), Expect = 0.077, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 10/100 (10%) Query: 238 LRMHKKKVTHVALNPC---------CDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PH 287 L+ H +K+TH NP C +LA + + I+D+ R L H Sbjct: 11 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 70 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 P+ + +SPDG LLT+ + I+++ S+ PL I Sbjct: 71 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 110 >5OQL-J nrPDB Length = 912 Score = 34.7 bits (78), Expect = 0.091, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 76/179 (42%), Gaps = 29/179 (16%) Query: 228 LNMDGKELWNLR--MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ------VRGKA 279 L GK +LR H K + + ++P F A+AS D+TVKIWD+ + +RG Sbjct: 528 LQKGGKLTSSLRRLAHDKDINALDISPNGKLF-ASASQDKTVKIWDVEKLEVQGILRGHK 586 Query: 280 SFLYSL---PHRHPV---NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRH 333 ++++ P PV S G L + K+ I++++ S + C H H Sbjct: 587 RGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKT-IKLWNLSDYTCIRTFEGHSH-- 643 Query: 334 FQHLTPIKAAWH--PRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 390 +K W R + I + F S L + V+D N+G+ C L + E Sbjct: 644 ----NVLKVVWLHISRDDSITKTKV---QFASAGADTL--VKVWDANTGETECTLDNHE 693 >6ID0-T nrPDB Length = 514 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 12/107 (11%) Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 +A+ P WF+ T S D+T+KIWDL + K S H V S L + Sbjct: 210 IAVEPGNQWFV-TGSADRTIKIWDLASGKLKLSL---TGHISTVRGVIVSTRSPYLFSCG 265 Query: 308 QKSEIRVYSASQWDCPLG-LIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 + +++ WD +I H H H + + HP +++V Sbjct: 266 EDKQVKC-----WDLEYNKVIRHYHGHLSAVYGLDL--HPTIDVLVT 305 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 57/150 (38%), Gaps = 9/150 (6%) Query: 171 QFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 230 Q S + T RL D RV ++ ++ L + + DN+ Sbjct: 344 QIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKF--P 401 Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR-----QVRGKASFLYSL 285 DG + NL H + + +N D L + + + T+ +WD R Q A SL Sbjct: 402 DGSFIQNLSGHNAIINTLTVN--SDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSL 459 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 + A F +RLLT + I+VY Sbjct: 460 DSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 20/130 (15%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H V + L+P D L T S D T +IWD VR KAS H + V Sbjct: 287 HLSAVYGLDLHPTID-VLVTCSRDSTARIWD---VRTKASVHTLSGHTNAVATVRCQAAE 342 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLIVVG----- 354 +++T + IR++ + L H ++A HPR+ G Sbjct: 343 PQIITGSHDTTIRLWDLVAGKTRVTLT-------NHKKSVRAVVLHPRHYTFASGSPDNI 395 Query: 355 ---RYPDPNF 361 ++PD +F Sbjct: 396 KQWKFPDGSF 405 >6EOJ-D nrPDB Length = 470 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 40/190 (21%), Positives = 79/190 (41%), Gaps = 18/190 (9%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 186 + V + G+ LWN T ++ ++T +K++ +++ + +G ++ Sbjct: 108 LVVATYSGEFSLWNASSFTFETLMQA--HDSAVTTMKYS-HDSDWMISGDADGMIKIWQP 164 Query: 187 KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVT 246 ++++ ++ T +I + + S + + DN+ + + +GK+ L H V Sbjct: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS-NGKQERVLSGHHWDVK 223 Query: 247 HVALNPCCDW-----FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGA 301 CDW +A+AS D VK+WD R +S L +H V F P Sbjct: 224 ------SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI---LKFKHTVLKTRFQPTKG 274 Query: 302 RLLTTDQKSE 311 LL K + Sbjct: 275 NLLMAISKDK 284 >5XYI-g nrPDB Length = 335 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 33/59 (55%), Gaps = 3/59 (5%) Query: 258 LATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 L T+S D T+++WDL K F L H+ V FSP R+++ + +++++++ Sbjct: 95 LLTSSWDSTLRLWDLSTRTTKKLF---LGHKKDVLGVTFSPCNRRIISVGRDNQVKIWN 150 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 34/64 (53%), Gaps = 2/64 (3%) Query: 257 FLATASVDQTVKIWDLRQVRGKAS--FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 +L +AS D++ +W L + + + + F + H H V+ S D + LLT+ S +R+ Sbjct: 47 YLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRL 106 Query: 315 YSAS 318 + S Sbjct: 107 WDLS 110 >4V6W-Ag nrPDB Length = 318 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 88/246 (35%), Gaps = 78/246 (31%) Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLW--------NFGIKDKPTFIKGIGAGGSITGLKFN 165 T +A +P P T+ S+ +++W N+G K + G I+ + + Sbjct: 18 VTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY----GHSHFISDVVLS 73 Query: 166 PLNTNQFYASSMEGTTRLQDFK-GNILRVFA--SSDTINIWFCSLDVSASSRMVVTGDNV 222 + N + S + T RL D G R F + D +++ F SA +R +V+G Sbjct: 74 S-DGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAF-----SADNRQIVSGSRD 127 Query: 223 GNVILLNM----------DGK---------------------------ELWNLRMHKKKV 245 + L N DG ++WNL K K Sbjct: 128 KTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKN 187 Query: 246 THVALNPCCDWFLATASV------------DQTVKIWDLRQVRGKASFLYSLPHRHPVNA 293 H N +L T +V D +WDL + LY+L H +NA Sbjct: 188 NHHGHNG----YLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKN----LYTLEHNDIINA 239 Query: 294 ACFSPD 299 CFSP+ Sbjct: 240 LCFSPN 245 >5WLC-LJ nrPDB Length = 513 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 21/126 (16%) Query: 157 GSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMV 216 S+T + FNP + + F +S +TR+Q F +V + S + +++ Sbjct: 40 NSVTHISFNPQHPHDFAVTS---STRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLL 96 Query: 217 VTGDNVGNV----------ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQT 266 GD G V ILL++ N H VT + + LATAS D+ Sbjct: 97 CAGDATGLVSVYDSYNPRTILLSI------NASTHPTHVT--KFHTQDNKILATASDDRV 148 Query: 267 VKIWDL 272 ++WD+ Sbjct: 149 TRLWDI 154 >5WYJ-BC nrPDB Length = 817 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 58/130 (44%), Gaps = 9/130 (6%) Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPC-CDWFLATASV 263 +L VS + + T + N++ EL L HK+ + V+ C D LAT+S Sbjct: 496 ALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSF--CQYDKLLATSSG 553 Query: 264 DQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322 D+TVKIW L S + +L H + V F +L++ I+++ S +C Sbjct: 554 DKTVKIWSLDTF----SVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGEC 609 Query: 323 PLGLIPHPHR 332 L H +R Sbjct: 610 LKTLDGHNNR 619 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 50/118 (42%), Gaps = 8/118 (6%) Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 IT LK P Y S + G ++R S I LD ++S ++ Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYI----LDADSTSTLLAV 119 Query: 219 GDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCD---WFLATASVDQTVKIWDL 272 G G++I+++++ G + + H ++ + + W LA+ + VK+WDL Sbjct: 120 GGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL 177 >3DM0-A nrPDB Length = 694 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 297 L H V+ VA++P A+ D V +WDL + GK LYSL ++A CFS Sbjct: 557 LAGHTGYVSTVAVSPDGS-LCASGGKDGVVLLWDLAE--GKK--LYSLEANSVIHALCFS 611 Query: 298 PD 299 P+ Sbjct: 612 PN 613 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 86/197 (43%), Gaps = 18/197 (9%) Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 T++A + + S+ I+LW DK + G ++ L+++ +A Sbjct: 386 TAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFA 445 Query: 175 --SSMEGTTRLQDFKGNI-LRVFA--SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 S +G RL D + R F + D +++ F SLD +R +V+ + L N Sbjct: 446 LSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAF-SLD----NRQIVSASRDRTIKLWN 500 Query: 230 MDGKELWNL----RMHKKKVTHVALNP-CCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284 G+ + + H+ V+ V +P + +AS D+TVK+W+L + +++ Sbjct: 501 TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTL--- 557 Query: 285 LPHRHPVNAACFSPDGA 301 H V+ SPDG+ Sbjct: 558 AGHTGYVSTVAVSPDGS 574 >5WYJ-BE nrPDB Length = 939 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 67/149 (44%), Gaps = 16/149 (10%) Query: 129 VGSKGGDIMLWNF--GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 186 +GS G I ++N GI K + ++TG+ + +N + + ++G DF Sbjct: 477 IGSSNGSITIYNMQSGILRKKYKLHK----RAVTGISLDGMN-RKMVSCGLDGIVGFYDF 531 Query: 187 KGNILRVFASSD---TINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKK 243 + L D T ++ S D+ A + D++ V++ + + + L H Sbjct: 532 NKSTLLGKLKLDAPITAMVYHRSSDLFA-----LALDDLSIVVIDAVTQRVVRQLWGHSN 586 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDL 272 ++T +P W + +AS+D T++ WDL Sbjct: 587 RITAFDFSPEGRW-IVSASLDSTIRTWDL 614 >3JAP-g nrPDB Length = 326 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 30/136 (22%), Positives = 62/136 (45%), Gaps = 12/136 (8%) Query: 201 NIWFCSLDVSASS-RMVVTGDNVGNVILLNMDGKE------LWNLRMHKKKVTHVALNPC 253 N W SL SA+ ++V+G +I + E + + + H V V ++ Sbjct: 18 NGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSAD 77 Query: 254 CDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIR 313 + + +AS D+T+++W+L +A F + H V + + +++++ + IR Sbjct: 78 GN-YAVSASWDKTLRLWNLATGNSEARF---VGHTGDVLSVAIDANSSKIISASRDKTIR 133 Query: 314 VYSASQWDCPLGLIPH 329 V++ DC L+ H Sbjct: 134 VWNTVG-DCAYVLLGH 148 >5A9Q-2 nrPDB Length = 326 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 6/86 (6%) Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 D E L H + + +P +A+ S D T +IW+L V+ L+S P Sbjct: 113 DKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHS-----P 167 Query: 291 VNAACFSPDGA-RLLTTDQKSEIRVY 315 + C+ P+ +L+ ++ IR Y Sbjct: 168 GMSVCWHPEETFKLMVAEKNGTIRFY 193 >5FA5-B nrPDB Length = 367 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 42/107 (39%), Gaps = 10/107 (9%) Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 294 L + R H +VT VA +P D + S D + +WD R + + S P P + A Sbjct: 185 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLA 244 Query: 295 ---------CFSPDGARLLTTDQKSEIRVY-SASQWDCPLGLIPHPH 331 F + + D KS V SA C GL+ PH Sbjct: 245 WHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPH 291 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 3/64 (4%) Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 TSLAWHP G + G + L K + +TGL F+P ++ F A Sbjct: 241 TSLAWHPQQSEVFVFGDENGTVSL--VDTKSTSCVLSSAVHSQCVTGLVFSP-HSVPFLA 297 Query: 175 SSME 178 S E Sbjct: 298 SLSE 301 >6QDV-o nrPDB Length = 513 Score = 32.0 bits (71), Expect = 0.57, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS-LPHRHPVNAACFSPD 299 H K V+ V L P L + S+D +K+W +V G+ L + + H V CF+ Sbjct: 221 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLW---EVYGERRCLRTFIGHSKAVRDICFNTA 277 Query: 300 GARLLTTDQKSEIRVYSASQWDC 322 G + L+ ++++ C Sbjct: 278 GTQFLSAAYDRYLKLWDTETGQC 300 >5YZG-W nrPDB Length = 579 Score = 31.6 bits (70), Expect = 0.62, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS-LPHRHPVNAACFSPD 299 H K V+ V L P L + S+D +K+W +V G+ L + + H V CF+ Sbjct: 287 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLW---EVYGERRCLRTFIGHSKAVRDICFNTA 343 Query: 300 GARLLTTDQKSEIRVYSASQWDC 322 G + L+ ++++ C Sbjct: 344 GTQFLSAAYDRYLKLWDTETGQC 366 >3JB9-L nrPDB Length = 340 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 27/55 (49%), Gaps = 3/55 (5%) Query: 261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 +D +KIWDLR S + H+ + + S DG+ LL+ + +R++ Sbjct: 195 GGIDGAIKIWDLRN--NHCSHVLK-GHKDIITSLAISKDGSSLLSNSMDNTVRIF 246 >3I2N-A nrPDB Length = 357 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 7/72 (9%) Query: 210 SASSRMVVTGDNVGNVILLNMDGKEL--WNLRMHKKKVTHVALNPCCDWF-----LATAS 262 S R + TGD GN+ + N++ E+ ++++ HK+ + + + T S Sbjct: 77 SLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 263 VDQTVKIWDLRQ 274 D TVK+WD RQ Sbjct: 137 RDGTVKVWDPRQ 148 >6G51-g nrPDB Length = 317 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 12/74 (16%) Query: 234 ELWNLRMHKKKVTHVA----LNPCC----DWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 ++WNL K K H+ LN A+ D +WDL + LY+L Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE----GKHLYTL 230 Query: 286 PHRHPVNAACFSPD 299 +NA CFSP+ Sbjct: 231 DGGDIINALCFSPN 244 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 10/84 (11%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP------HRHPV 291 L+ H VT +A P + +AS D+T+ +W L + Y +P H H V Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN----YGIPQRALRGHSHFV 66 Query: 292 NAACFSPDGARLLTTDQKSEIRVY 315 + S DG L+ +R++ Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLW 90 >1NR0-A nrPDB Length = 611 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 F+A D V ++ L S + ++ H + + FS +GA L+ TDQ ++ YS Sbjct: 462 FVAVGGQDSKVHVYKLSG--ASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYS 519 Query: 317 ASQ 319 + Sbjct: 520 VAN 522 >6EM1-m nrPDB Length = 807 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 HK KV ++++P W LAT S D TV++W++ Sbjct: 436 HKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 466 >4G56-B nrPDB Length = 357 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 35/71 (49%), Gaps = 3/71 (4%) Query: 111 DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTN 170 D TS+ WHP T A G + G++ L N IK+ + +ITGL ++ +++ Sbjct: 226 DTIPTSVTWHPEKDDTFACGDETGNVSLVN--IKNPDSAQTSAVHSQNITGLAYS-YHSS 282 Query: 171 QFYASSMEGTT 181 F AS E T Sbjct: 283 PFLASISEDCT 293 >6C0F-s nrPDB Length = 807 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 HK KV ++++P W LAT S D TV++W++ Sbjct: 436 HKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 466 >1S5J-A nrPDB Length = 847 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 20/31 (64%), Gaps = 1/31 (3%) Query: 367 YELRTIDVFDGNSGKMMCQLYDPESSGISSL 397 Y L +D +DG GK +C+L+D E+ I +L Sbjct: 16 YFLLQVD-YDGKKGKAVCKLFDKETQKIYAL 45 >6CB1-s nrPDB Length = 569 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 HK KV ++++P W LAT S D TV++W++ Sbjct: 198 HKGKVRTLSIDPSGLW-LATGSDDGTVRVWEI 228 >6J6H-n nrPDB Length = 455 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 23/102 (22%), Positives = 38/102 (37%), Gaps = 21/102 (20%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD-------LRQVRGKASFLYSL 285 K + N H + T + P + + D T+KIWD LR +G Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG-------- 204 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 H P+ A F+ D L++ +++ WD G + Sbjct: 205 -HNKPIKALRFTEDCQSFLSSSFDRSVKI-----WDTETGKV 240 >5OQL-L nrPDB Length = 557 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 3/48 (6%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLL 304 L + S D+TV++WD R G + + H P+ P G LL Sbjct: 204 LLVSGSYDETVRVWDARAPGGA---VMTFKHADPIEDVLPLPSGTTLL 248 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 34/141 (24%), Positives = 62/141 (43%), Gaps = 17/141 (12%) Query: 208 DVSASSRMVVTGDNVGNVILLNM-DGKELWNLR---MHKKKVTHVALNPCCDWFLATASV 263 ++ R++V G++ G + + ++ G L+ +HK+ V +P L + S Sbjct: 106 EIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSD 165 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGAR---LLTTDQKSEIRVYSASQW 320 D+TV++WDL + L++ H V F P A L++ +RV+ A Sbjct: 166 DKTVRLWDLPS--NDPTRLFT-GHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDAR-- 220 Query: 321 DCPLGLIPHPHRHFQHLTPIK 341 P G + F+H PI+ Sbjct: 221 -APGGAV----MTFKHADPIE 236 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 67/159 (42%), Gaps = 15/159 (9%) Query: 119 WHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG----IGAGGSITGLKFNPLNTNQFYA 174 W PT +T+ S + LW+ D G + G + G N+N + Sbjct: 152 WSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPG----SANSNLLVS 207 Query: 175 SSMEGTTRLQDFK--GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG 232 S + T R+ D + G + F +D I L + + + ++ N +V+ L + Sbjct: 208 GSYDETVRVWDARAPGGAVMTFKHADPIE---DVLPLPSGTTLLAASGNAISVLDL-VAA 263 Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 K L + H+K VT ++L + + S+D VK+++ Sbjct: 264 KPLRLITNHQKTVTSLSL-ASQGRRVVSGSLDGHVKVFE 301 >6ELZ-p nrPDB Length = 460 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 20/33 (60%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 HK V+ + P ++ L + S D TVK+WD+R Sbjct: 374 HKNFVSSLDTCPENEYILCSGSHDGTVKVWDVR 406 >1TMO-A nrPDB Length = 829 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 22/95 (23%), Positives = 36/95 (37%), Gaps = 10/95 (10%) Query: 329 HPHRHFQHLTPIKAAWHPRYNLIVVG-------RYPDPNFKSCTPYELRTIDVFDGNSGK 381 +P H Q +K A+H ++ V R+ D +CT YE IDV+ + + Sbjct: 474 NPWNHHQDRNRMKQAFHKLECVVTVDVNWTATCRFSDIVLPACTTYERNDIDVYGAYANR 533 Query: 382 ---MMCQLYDPESSGISSLNEFNPMGDTLASAMGY 413 M ++ +P +S F L Y Sbjct: 534 GILAMQKMVEPLFDSLSDFEIFTRFAAVLGKEKEY 568 >5OQL-X nrPDB Length = 630 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 207 LDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265 + S + VVTG +++ N D K + H+ VT +A + L + S D+ Sbjct: 252 VKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQ-LYSCSKDR 310 Query: 266 TVKIWDLRQV 275 TVK+W L ++ Sbjct: 311 TVKVWSLDEL 320 >5MWJ-A nrPDB Length = 337 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 27/137 (19%), Positives = 54/137 (39%), Gaps = 7/137 (5%) Query: 134 GDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRV 193 G+I +W+ + +G G S + + + + ++ T R D + R Sbjct: 163 GNIAVWDLHNQTLVRQFQGHTDGASCIDISND---GTKLWTGGLDNTVRSWDLREG--RQ 217 Query: 194 FASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPC 253 D + F SL + + G NV +L+++ + + L +H+ V + C Sbjct: 218 LQQHDFTSQIF-SLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYC 276 Query: 254 CDWFLATASVDQTVKIW 270 WF++T D + W Sbjct: 277 GKWFVSTGK-DNLLNAW 292 >6E29-D nrPDB Length = 345 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 6/35 (17%) Query: 257 FLATASVDQTVKIWDL------RQVRGKASFLYSL 285 FLA+ VD TV IWDL R++RG + + SL Sbjct: 39 FLASGRVDGTVVIWDLETMGVARKLRGHSKNITSL 73 >4PSX-B nrPDB Length = 401 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 56/284 (19%), Positives = 110/284 (38%), Gaps = 43/284 (15%) Query: 63 LPPCRSIVRTL----HQHKLGRASW----PSVQ---QGLQQSFLHTLDSYRILQKAAPFD 111 LP RS +R H+ ++ RA + P++ G +FL++ LQ F Sbjct: 102 LPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYS--RSEGLQSTLKFH 159 Query: 112 R-RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS-----ITGLKFN 165 + +L++ + GS + LW G PT K + I K++ Sbjct: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPT--KPVRTWNDLHSDIINDNKWH 217 Query: 166 PLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIW--FCSLDVSASSRMVVTGDNVG 223 N + F S + ++ D + N + DT+ F +L S S ++ + Sbjct: 218 NFNKDLFGTVSEDSLLKINDVRANNTTI----DTVKCPQPFNTLAFSHHSSNLLAAAGMD 273 Query: 224 NVILL----NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKA 279 + + L NM + L ++ H+ V ++ + D + ++ D + +WDL+Q+ + Sbjct: 274 SYVYLYDLRNM-KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQ 332 Query: 280 S-----------FLYSLPHRHPVNAACFSPDGARLLTTDQKSEI 312 + + HR VN +P L+ + ++ I Sbjct: 333 TPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENI 376 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4E5Z-B nrPDB 609 e-175 3EI3-B nrPDB 438 e-123 5GAN-H nrPDB 321 3e-88 5NNZ-B nrPDB 227 7e-60 5OPT-p nrPDB 212 2e-55 4V8M-A7 nrPDB 211 5e-55 5WLC-LO nrPDB 210 1e-54 5I2T-A nrPDB 208 5e-54 6MZM-G nrPDB 189 3e-48 6F3T-A nrPDB 189 3e-48 4A11-B nrPDB 178 3e-45 5M25-A nrPDB 174 6e-44 2H9P-A nrPDB 172 3e-43 6GMH-W nrPDB 167 6e-42 6HHQ-h nrPDB 162 3e-40 2HES-X nrPDB 154 7e-38 5FVM-C nrPDB 144 6e-35 6QX9-4B nrPDB 141 6e-34 6EMK-B nrPDB 133 1e-31 3C9C-A nrPDB 130 9e-31 5Y1U-A nrPDB 130 1e-30 3FM0-A nrPDB 128 5e-30 5WJC-A nrPDB 127 9e-30 3CFV-B nrPDB 124 6e-29 4XYI-A nrPDB 119 3e-27 5CXC-A nrPDB 118 5e-27 Sequences not found previously or not previously below threshold: 5MZH-A nrPDB 193 2e-49 1VYH-C nrPDB 166 2e-41 6HQA-B nrPDB 161 4e-40 6G51-g nrPDB 155 5e-38 4V6W-Ag nrPDB 151 5e-37 3DM0-A nrPDB 145 4e-35 5FL8-q nrPDB 135 3e-32 3JAP-g nrPDB 135 4e-32 4BTS-AR nrPDB 130 1e-30 2YNP-A nrPDB 127 9e-30 3MKQ-A nrPDB 127 1e-29 6QX9-5O nrPDB 126 2e-29 4V7E-Bg nrPDB 125 3e-29 5Y88-O nrPDB 124 6e-29 5Z56-q nrPDB 124 8e-29 5NZU-C nrPDB 122 3e-28 6Q8F-A nrPDB 122 4e-28 4LG8-A nrPDB 121 4e-28 5WYK-BB nrPDB 118 5e-27 6ID0-T nrPDB 115 3e-26 5UZ7-B nrPDB 115 3e-26 6QDV-o nrPDB 113 2e-25 5YZG-W nrPDB 112 3e-25 4L9O-A nrPDB 107 1e-23 6N9G-C nrPDB 106 2e-23 3JB9-L nrPDB 106 2e-23 5OQL-J nrPDB 105 5e-23 4YCZ-A nrPDB 104 5e-23 5WYJ-BC nrPDB 104 7e-23 3JRO-A nrPDB 103 1e-22 5XYI-g nrPDB 103 2e-22 5K1B-B nrPDB 101 5e-22 6EOJ-D nrPDB 101 8e-22 5WBU-D nrPDB 100 1e-21 6BX3-A nrPDB 100 1e-21 3JRP-A nrPDB 100 2e-21 3W15-A nrPDB 98 7e-21 4BZK-B nrPDB 98 8e-21 5OQL-L nrPDB 97 1e-20 4J0W-A nrPDB 95 7e-20 4GGA-A nrPDB 94 1e-19 5LCW-Q nrPDB 94 1e-19 5G04-R nrPDB 94 1e-19 4N14-A nrPDB 94 1e-19 6ELZ-p nrPDB 94 1e-19 2AQ5-A nrPDB 93 2e-19 5OQL-d nrPDB 92 4e-19 6CHG-A nrPDB 92 5e-19 3ODT-A nrPDB 92 5e-19 1NR0-A nrPDB 91 7e-19 5A31-R nrPDB 90 2e-18 5L9T-R nrPDB 89 3e-18 5WLC-LU nrPDB 88 6e-18 3BG0-A nrPDB 88 9e-18 5FA5-B nrPDB 87 1e-17 4BH6-A nrPDB 87 1e-17 4PSX-B nrPDB 87 1e-17 4XFV-A nrPDB 86 2e-17 3JB9-g nrPDB 86 3e-17 4AEZ-A nrPDB 85 6e-17 5BJS-A nrPDB 84 9e-17 2PM9-A nrPDB 83 2e-16 5OV3-A nrPDB 82 4e-16 4U1E-I nrPDB 80 2e-15 5WLC-LJ nrPDB 79 4e-15 6J6H-n nrPDB 79 4e-15 5M89-A nrPDB 79 5e-15 4G56-B nrPDB 79 5e-15 3ACP-A nrPDB 78 6e-15 5N4A-A nrPDB 77 1e-14 3JZG-A nrPDB 73 2e-13 5WYJ-BE nrPDB 73 3e-13 5A9Q-2 nrPDB 71 1e-12 5A9Q-7 nrPDB 71 1e-12 5MWJ-A nrPDB 70 1e-12 6CB1-s nrPDB 69 2e-12 6F1U-h nrPDB 69 3e-12 2P9P-C nrPDB 69 3e-12 6C0F-s nrPDB 69 3e-12 6EM1-m nrPDB 69 4e-12 5A9Q-0 nrPDB 67 2e-11 5CXB-B nrPDB 66 3e-11 3JB9-S nrPDB 66 3e-11 6E29-D nrPDB 66 4e-11 5WLC-LN nrPDB 66 4e-11 5K0Y-T nrPDB 65 5e-11 1PI6-A nrPDB 65 6e-11 6BX3-B nrPDB 64 8e-11 4OWR-A nrPDB 64 8e-11 5YZG-2 nrPDB 64 1e-10 3F3P-A nrPDB 62 5e-10 5K19-A nrPDB 61 8e-10 3I2N-A nrPDB 61 1e-09 5WLC-LW nrPDB 59 3e-09 5OQL-X nrPDB 59 3e-09 6CHG-D nrPDB 58 8e-09 5MC6-j nrPDB 56 4e-08 3DW8-B nrPDB 54 1e-07 5AMS-A nrPDB 54 2e-07 4J0X-A nrPDB 54 2e-07 5WLC-SG nrPDB 53 2e-07 5TF2-A nrPDB 53 3e-07 2I3T-A nrPDB 51 9e-07 5AJA-A nrPDB 50 2e-06 4AV8-A nrPDB 50 2e-06 6IYY-A nrPDB 49 3e-06 3DWL-C nrPDB 46 2e-05 6CVZ-A nrPDB 46 3e-05 2VDU-B nrPDB 46 4e-05 5WLC-LH nrPDB 44 9e-05 5WLC-LS nrPDB 43 2e-04 5LTD-A nrPDB 41 7e-04 6N8P-A nrPDB 41 0.001 5BPT-A nrPDB 38 0.008 2XE4-A nrPDB 36 0.026 4YHC-A nrPDB 36 0.042 6NAU-A nrPDB 35 0.051 4CAB-A nrPDB 34 0.10 5GRS-A nrPDB 34 0.11 1XFD-A nrPDB 33 0.20 1C5K-A nrPDB 33 0.20 5BPW-A nrPDB 33 0.23 4R40-A nrPDB 33 0.27 1RI6-A nrPDB 33 0.39 5CWW-B nrPDB 32 0.48 1CII-A nrPDB 31 0.87 3V91-A nrPDB 31 1.1 1ZCU-A nrPDB 31 1.2 4RS1-B nrPDB 31 1.4 3I4X-A nrPDB 31 1.5 2RD7-C nrPDB 30 1.8 2ZZW-A nrPDB 29 2.9 3DWO-X nrPDB 29 3.3 >4E5Z-B nrPDB Length = 436 Score = 609 bits (1571), Expect = e-175, Method: Composition-based stats. Identities = 422/423 (99%), Positives = 422/423 (99%), Gaps = 1/423 (0%) Query: 6 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP 65 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP Sbjct: 14 RPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPP 73 Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 125 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS Sbjct: 74 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 133 Query: 126 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD Sbjct: 134 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 193 Query: 186 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV 245 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV Sbjct: 194 FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV 253 Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 305 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT Sbjct: 254 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 313 Query: 306 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 365 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT Sbjct: 314 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 373 Query: 366 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS-QEEAR 424 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS QEEAR Sbjct: 374 PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSEQEEAR 433 Query: 425 TRK 427 TRK Sbjct: 434 TRK 436 >3EI3-B nrPDB Length = 383 Score = 438 bits (1126), Expect = e-123, Method: Composition-based stats. Identities = 192/369 (52%), Positives = 270/369 (73%), Gaps = 4/369 (1%) Query: 56 GLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRAT 115 G G Q SI+ +++ LG++ ++Q LQ+ F+ +L SY++ + A+PFDRR T Sbjct: 18 GRTGGQKKVGQTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVT 77 Query: 116 SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYAS 175 SL WHPTHP+TVAVGSKGGDI+LW++ +++K +FI+G+G G +ITG+KFN NTNQ + S Sbjct: 78 SLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFVS 137 Query: 176 SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL 235 S+ G T L+DF G++++VFA +D+ + W+C +DVS S +M+ TGD+ G ++LL +DG E+ Sbjct: 138 SIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEI 197 Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 + ++HK KVTH NP CDW +AT+SVD TVK+WDLR ++ K S++ +PH PVNAA Sbjct: 198 FKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAY 257 Query: 296 FSP-DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 354 F+P D +LLTTDQ++EIRVYS+ W P +I HPHR FQHLTPIKA WHP Y+LIV G Sbjct: 258 FNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAG 317 Query: 355 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH 414 RYPD + RTID++D NSG ++ QL DP ++GI SLN+F+P GD LAS MG++ Sbjct: 318 RYPDDQL---LLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN 374 Query: 415 ILIWSQEEA 423 ILIW++E+ Sbjct: 375 ILIWNREDT 383 >5GAN-H nrPDB Length = 465 Score = 321 bits (823), Expect = 3e-88, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 139/342 (40%), Gaps = 25/342 (7%) Query: 9 TQKTSEIVLRPRN------KRSRSPLELEPEA-KKLCAKGSGPSRRCDSDCLW-VGLAGP 60 T TSE++ R +RSR L+ E E +K + SRR + + + LAG Sbjct: 111 TPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGS 170 Query: 61 QILP--PCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLA 118 Q++ P ++ + + SW Q L L L QK + ++ Sbjct: 171 QLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPL-----TQKLDSHVGKIGAID 225 Query: 119 WHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG--IGAGGSITGLKFNPLNTNQFYASS 176 WHP + + ++ G I + + ++ + G +G I+ +K++P ++S Sbjct: 226 WHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGK-FIGSAS 284 Query: 177 MEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKEL 235 + T RL D + + ++ S +V +G +L ++ G ++ Sbjct: 285 HDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCD--GSLVCSGGMDSLSMLWDIRSGSKV 342 Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 L H K + VA +P + +AT D + +WD+R+ R + L HR+ V Sbjct: 343 MTLAGHSKPIYTVAWSPNG-YQVATGGGDGIINVWDIRK-RDEGQLNQILAHRNIVTQVR 400 Query: 296 FSPD--GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQ 335 FS + G +L++ + I VYS+ W L H + Sbjct: 401 FSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIIS 442 Score = 64.5 bits (155), Expect = 9e-11, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 73/190 (38%), Gaps = 11/190 (5%) Query: 208 DVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 + ++ + + L + G +L + K ++ V+L+ D +AT S + Sbjct: 145 KFNTRQELLSRRTELQRMANLELAGSQLVS----TKPISAVSLSTD-DMVVATGSWAGDL 199 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGA-RLLTTDQKSEIRVYSASQWDCPLGL 326 ++ L + H + A + PD ++++ + I+ + S + L L Sbjct: 200 QV--LNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRL 257 Query: 327 IPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386 + H + ++ +K +HP I + D ++ + + + +G+ + Sbjct: 258 LGDLVGHERRISDVK--YHPSGKFIGSASH-DMTWRLWDASTHQELLLQEGHDKGVFSLS 314 Query: 387 YDPESSGISS 396 + + S + S Sbjct: 315 FQCDGSLVCS 324 >5NNZ-B nrPDB Length = 415 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 128/327 (39%), Gaps = 40/327 (12%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG 154 L+TL+ +R + A F+ +P + +A GS LW+ ++ + G Sbjct: 127 LNTLEGHRNVVYAIAFN--------NP-YGDKIATGSFDKTCKLWS--VETGKCYHTFRG 175 Query: 155 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 214 I L FNP +T SM+ T +L D + + I SL + S Sbjct: 176 HTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI--ISLSFNTSGD 232 Query: 215 MVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 ++TG V++ + D G+++ L H +++ + N C L T S+D+T K+WD Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMDKTCKLWDAT 291 Query: 274 QVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRH 333 + A+ H + +CF G + T R++SA+ C L H Sbjct: 292 NGKCVATLT---GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI 348 Query: 334 FQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSG 393 + +++P+ N ++ G D + + + V +G++ ++ Sbjct: 349 SK------ISFNPQGNHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSC-------- 393 Query: 394 ISSLNEFNPMGDTLASAMGYHI-LIWS 419 FN G+ + + + IW Sbjct: 394 -----AFNYKGNIVITGSKDNTCRIWR 415 Score = 121 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 43/270 (15%), Positives = 92/270 (34%), Gaps = 22/270 (8%) Query: 142 GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ------DFKGNILRVFA 195 +K K + +G ++ L +S +L N F Sbjct: 24 ELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFY 83 Query: 196 SSDTINIW---FCSLDVSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALN 251 + ++ ++ S +TG L + G+EL L H+ V +A N Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 252 PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE 311 +AT S D+T K+W + + +F H + F+P + T + Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFR---GHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 312 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 371 +++ + L H I +++ + I+ G + D R Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEI------ISLSFNTSGDRIITGSF-DHTVVVWDADTGRK 253 Query: 372 IDVFDGNSGKMMCQLYDPESSGI--SSLNE 399 +++ G+ ++ ++ + S I S+++ Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDK 283 >5OPT-p nrPDB Length = 318 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 24/265 (9%) Query: 117 LAWHPTHPSTVAVGSK---------GGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPL 167 L H S VA+ + + LWN ++ K +G + + F+P Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWN--LQTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS--SRMVVTGDNVGNV 225 N Q + + R+ + KG L + W + S S + ++V+G V Sbjct: 121 NR-QIVSGGRDNALRVWNVKGECLHTLGRGAHTD-WVSCVRFSPSLETPLIVSGGWDNLV 178 Query: 226 ILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284 + ++ G+ L +L+ H +T V ++P A++ D ++WDL K L Sbjct: 179 KVWDIASGRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLWDLT----KGEALSE 233 Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP-IKAA 343 + P+N CFSP+ + +K IR++ D + L P + + + A Sbjct: 234 MAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIA 292 Query: 344 WHPRYNLIVVGRYPDPNFKSCTPYE 368 W N + G Y D + + E Sbjct: 293 WSADGNTLYSG-YTDNVIRVWSVSE 316 Score = 94.1 bits (232), Expect = 9e-20, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 87/209 (41%), Gaps = 8/209 (3%) Query: 191 LRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVAL 250 + A + ++ S + ++ G N+ G L H V+ VAL Sbjct: 16 VTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVAL 75 Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS 310 + D+ +AS D ++++W+L+ + F L H V + FSPD ++++ + + Sbjct: 76 SNNGDFA-VSASWDHSLRLWNLQTGVCQHKF---LGHTKDVLSVTFSPDNRQIVSGGRDN 131 Query: 311 EIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELR 370 +RV++ + +C L H + ++ ++ + LIV G + D K R Sbjct: 132 ALRVWNV-KGECLHTLGRGAHTDW--VSCVRFSPSLETPLIVSGGW-DNLVKVWDIASGR 187 Query: 371 TIDVFDGNSGKMMCQLYDPESSGISSLNE 399 + G++ + P+ S +S ++ Sbjct: 188 LLTDLKGHTNYITSVTVSPDGSLCASSDK 216 >4V8M-A7 nrPDB Length = 318 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 107/262 (40%), Gaps = 26/262 (9%) Query: 117 LAWHPTHPSTVAVGSKGG---------DIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPL 167 L H S VA+ + G + LWN +++ K +G + + F+P Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWN--LQNGQCQYKFLGHTKDVLSVAFSPD 120 Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS--SRMVVTGDNVGNV 225 N Q + + R+ + KG + + + W + S S + ++V+G V Sbjct: 121 NR-QIVSGGRDNALRVWNVKGECMHTLSRGAHTD-WVSCVRFSPSLDAPVIVSGGWDNLV 178 Query: 226 ILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284 + ++ G+ + +L+ H VT V ++P A++ D ++WDL + L Sbjct: 179 KVWDLATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLWDLTKGEA----LSE 233 Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP--IKA 342 + P+N CFSP+ + +K IR++ D + L P H+ + + P + Sbjct: 234 MAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPE-HQGSKKIVPECVSI 291 Query: 343 AWHPRYNLIVVGRYPDPNFKSC 364 AW + + G Y D + Sbjct: 292 AWSADGSTLYSG-YTDNVIRVW 312 >5WLC-LO nrPDB Length = 923 Score = 210 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 59/224 (26%), Positives = 98/224 (43%), Gaps = 15/224 (6%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +SY IL++ FD SLA+ P S V S+ G I +W+ I S Sbjct: 335 ESY-ILKQQGHFDS-TNSLAYSPD-GSRVVTASEDGKIKVWD--ITSGFCLATFEEHTSS 389 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVV 217 +T ++F F +SS++GT R D + R F ++ I F L V S +V Sbjct: 390 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCLAVDPSGEVVC 446 Query: 218 TG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 G DN + G+ L L H+ V+ ++ + LA+AS D+T++IW + Sbjct: 447 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIW---SI 502 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 G++ + + V A PDG + + K +I +++ Sbjct: 503 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIED 546 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 64/389 (16%), Positives = 128/389 (32%), Gaps = 58/389 (14%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLH------TLDSYRILQKAAPFDRRATSLAW 119 C ++ + AS Q + ++ +R+ A F + TSL W Sbjct: 99 CSAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVH--AGHF-QDITSLTW 154 Query: 120 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK-GIGAGGSITGLKFNPLNTNQFYASSME 178 + SK +W+ ++K G + G F+ + + Y S + Sbjct: 155 SQDS-RFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFS-HDQEKIYTVSKD 212 Query: 179 GTTRLQDFKGN--------------ILRVFASSDTI-----------NIWFCSLDVSASS 213 G + +F V S + + ++ Sbjct: 213 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 272 Query: 214 RMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 R++ G G L ++ D + L M + V V++N +W +S + ++ Sbjct: 273 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY-- 330 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 + + ++ L H N+ +SPDG+R++T + +I+V+ D G Sbjct: 331 -EWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW-----DITSGFCLATFE 384 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG-KMMCQLYDPES 391 +H + + A + ++ D ++ R F G + C DP Sbjct: 385 --EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSG 442 Query: 392 SGI--SSLNEFN------PMGDTLASAMG 412 + SL+ F+ G L + G Sbjct: 443 EVVCAGSLDNFDIHVWSVQTGQLLDALSG 471 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 61/332 (18%), Positives = 115/332 (34%), Gaps = 37/332 (11%) Query: 100 SYRILQKAAPF--DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 S+RI +K + + + +HP +AVG G+ L++ + D + Sbjct: 247 SWRITKKHFFYANQAKVKCVTFHPAT-RLLAVGFTSGEFRLYD--LPDFTLIQQLSMGQN 303 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + + N + SS G + +++ + + SL S VV Sbjct: 304 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDST--NSLAYSPDGSRVV 361 Query: 218 TGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 T G + + ++ G L H VT V + ++S+D TV+ WDL +R Sbjct: 362 TASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDL--IR 418 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS-EIRVYSASQWDCPLGLIPHPHRHFQ 335 + ++ R N P G + + +I V+S L H Sbjct: 419 YRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHE----- 473 Query: 336 HLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPES--SG 393 P+ + N ++ D + + + Q +P S Sbjct: 474 --GPVSCLSFSQENSVLASASWDKTIRIWSIFGR--------------SQQVEPIEVYSD 517 Query: 394 ISSLNEFNPMGDTLA-SAMGYHILIWSQEEAR 424 + +L P G +A S + I I++ E+A+ Sbjct: 518 VLAL-SMRPDGKEVAVSTLKGQISIFNIEDAK 548 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 25/172 (14%), Positives = 54/172 (31%), Gaps = 17/172 (9%) Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 + + L+ V ++DL + SF + HR + A + G L++ D Sbjct: 20 ITFSDDGKQLLSPVGN--RVSVFDLINNK---SFTFEYEHRKNIAAIDLNKQGTLLISID 74 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 + + + + +P + + GR+ +K+ Sbjct: 75 EDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLF-----ALASGRFLQ-IWKTPDVN 128 Query: 368 ELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS 419 + R F + +++ I+SL L ++ IWS Sbjct: 129 KDRQFAPF------VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWS 174 >5I2T-A nrPDB Length = 742 Score = 208 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 59/224 (26%), Positives = 98/224 (43%), Gaps = 15/224 (6%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +SY IL++ FD SLA+ P S V S+ G I +W+ I S Sbjct: 360 ESY-ILKQQGHFDS-TNSLAYSPD-GSRVVTASEDGKIKVWD--ITSGFCLATFEEHTSS 414 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVV 217 +T ++F F +SS++GT R D + R F ++ I F L V S +V Sbjct: 415 VTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQ--FNCLAVDPSGEVVC 471 Query: 218 TG--DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 G DN + G+ L L H+ V+ ++ + LA+AS D+T++IW + Sbjct: 472 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIW---SI 527 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 G++ + + V A PDG + + K +I +++ Sbjct: 528 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIED 571 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 64/389 (16%), Positives = 128/389 (32%), Gaps = 58/389 (14%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLH------TLDSYRILQKAAPFDRRATSLAW 119 C ++ + AS Q + ++ +R+ A F + TSL W Sbjct: 124 CSAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVH--AGHF-QDITSLTW 179 Query: 120 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK-GIGAGGSITGLKFNPLNTNQFYASSME 178 + SK +W+ ++K G + G F+ + + Y S + Sbjct: 180 SQDS-RFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFS-HDQEKIYTVSKD 237 Query: 179 GTTRLQDFKGN--------------ILRVFASSDTI-----------NIWFCSLDVSASS 213 G + +F V S + + ++ Sbjct: 238 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 297 Query: 214 RMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 R++ G G L ++ D + L M + V V++N +W +S + ++ Sbjct: 298 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVY-- 355 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 + + ++ L H N+ +SPDG+R++T + +I+V+ D G Sbjct: 356 -EWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW-----DITSGFCLATFE 409 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG-KMMCQLYDPES 391 +H + + A + ++ D ++ R F G + C DP Sbjct: 410 --EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSG 467 Query: 392 SGI--SSLNEFN------PMGDTLASAMG 412 + SL+ F+ G L + G Sbjct: 468 EVVCAGSLDNFDIHVWSVQTGQLLDALSG 496 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 107/304 (35%), Gaps = 21/304 (6%) Query: 100 SYRILQKAAPF--DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 S+RI +K + + + +HP +AVG G+ L++ + D + Sbjct: 272 SWRITKKHFFYANQAKVKCVTFHPAT-RLLAVGFTSGEFRLYD--LPDFTLIQQLSMGQN 328 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + + N + SS G + +++ + + SL S VV Sbjct: 329 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDST--NSLAYSPDGSRVV 386 Query: 218 TGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 T G + + ++ G L H VT V + ++S+D TV+ WDL +R Sbjct: 387 TASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQ-VMFSSSLDGTVRAWDL--IR 443 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS-EIRVYSASQWDCPLGLIPHPHRHFQ 335 + ++ R N P G + + +I V+S L H Sbjct: 444 YRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHE----- 498 Query: 336 HLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY-ELRTIDVFDGNSGKMMCQLY-DPESSG 393 P+ + N ++ D + + + + ++ + S + + D + Sbjct: 499 --GPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVA 556 Query: 394 ISSL 397 +S+L Sbjct: 557 VSTL 560 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 25/172 (14%), Positives = 54/172 (31%), Gaps = 17/172 (9%) Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 + + L+ V ++DL + SF + HR + A + G L++ D Sbjct: 45 ITFSDDGKQLLSPVGN--RVSVFDLINNK---SFTFEYEHRKNIAAIDLNKQGTLLISID 99 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 + + + + +P + + GR+ +K+ Sbjct: 100 EDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLF-----ALASGRFLQ-IWKTPDVN 153 Query: 368 ELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS 419 + R F + +++ I+SL L ++ IWS Sbjct: 154 KDRQFAPF------VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWS 199 >5MZH-A nrPDB Length = 452 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 61/325 (18%), Positives = 116/325 (35%), Gaps = 40/325 (12%) Query: 97 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG 156 TL+ ++ + A F+ +P + + GS LW+ + G Sbjct: 131 TLEGHKNVVYAIAFN--------NP-YGDKIVTGSFDKTCKLWDAY--TGQLYYTLKGHQ 179 Query: 157 GSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMV 216 I L FNP +T SM+ T +L D + R + I SL + ++ Sbjct: 180 TEIVCLSFNPQST-IIATGSMDNTAKLWDVETGQERATLAGHRAEI--VSLGFNTGGDLI 236 Query: 217 VTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 VTG + L ++ G+ + L H+ +V+ N + + S+D T ++WD+R Sbjct: 237 VTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSG 295 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQ 335 R + H V F G ++++ R+Y C L+ H + Sbjct: 296 RCLSVKQ---GHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISK 352 Query: 336 HLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGIS 395 A++P+ ++ D + + V +G++ ++ Sbjct: 353 ------VAFNPQGTRLITASS-DKTCRLWDCDTGECLQVLEGHTDEIFSC---------- 395 Query: 396 SLNEFNPMGDTLASAMGYHI-LIWS 419 FN GD + + + IW Sbjct: 396 ---AFNYEGDFIITGSKDNTCRIWK 417 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 109/341 (31%), Gaps = 35/341 (10%) Query: 84 PSVQQGLQQSFLHTLD----SYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLW 139 P+++Q + + L+ S+ + + T+ A++ GS +W Sbjct: 63 PALRQLIHRLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFN-KSGDRFITGSYDRTCKVW 121 Query: 140 NFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDT 199 N G + + FN ++ S + T +L D L Sbjct: 122 NTF--TGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQ 179 Query: 200 INIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFL 258 I L + S ++ TG L ++ G+E L H+ ++ + N D + Sbjct: 180 TEI--VCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGD-LI 236 Query: 259 ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318 T S D ++WD+R + HR V++ F+ G +++ R++ Sbjct: 237 VTGSFDHDSRLWDVRTGQCVHVLS---GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVR 293 Query: 319 QWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGN 378 C H + A+ +V D + + G+ Sbjct: 294 SGRCLSVKQGHTDEV------LDVAFDAAGTKMVSAS-ADGSARLYHTLTGVCQHTLVGH 346 Query: 379 SGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHI-LIW 418 G++ S FNP G L +A +W Sbjct: 347 EGEI-------------SKVAFNPQGTRLITASSDKTCRLW 374 >6MZM-G nrPDB Length = 800 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 80/217 (36%), Gaps = 15/217 (6%) Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 G G + G F+P + N +SS +GT RL + V +W S Sbjct: 540 YGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPY 596 Query: 213 SRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 V+G + L D + L H V +P ++ +AT S D+TV++WD Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSADRTVRLWD 655 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 + + G +++ H+ P+++ FSP+G L T + ++ L H Sbjct: 656 V--LNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712 Query: 332 RHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYE 368 T + ++ G D + + Sbjct: 713 ------TVCSLRFSRDGEILASGS-MDNTVRLWDAIK 742 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 76/210 (36%), Gaps = 13/210 (6%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 ++ P + + S+ G + LW+ ++ + G + +F+P Sbjct: 542 HSGPVYGASFSPDR-NYLLSSSEDGTVRLWS--LQTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 F + + RL + ++ +S V TG V L + Sbjct: 599 -YFVSGGHDRVARLWATDHYQPLRIFAGHLADV--NCTRFHPNSNYVATGSADRTVRLWD 655 Query: 230 M-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PH 287 + +G + HK + + +P + LAT + D V +WD+ G + L H Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRF-LATGATDGRVLLWDI----GHGLMVGELKGH 710 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 V + FS DG L + + +R++ A Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 36/185 (19%), Positives = 65/185 (35%), Gaps = 27/185 (14%) Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 L H V + +P ++ L ++S D TV++W L+ + H +PV Sbjct: 537 KILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTC---LVGYKGHNYPVWDTQ 592 Query: 296 FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA-WHPRYNLIVVG 354 FSP G ++ R+++ + HL + +HP N + G Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAG-------HLADVNCTRFHPNSNYVATG 645 Query: 355 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY- 413 D + + +F G+ G + F+P G LA+ Sbjct: 646 SA-DRTVRLWDVLNGNCVRIFTGHKGPIHSLT-------------FSPNGRFLATGATDG 691 Query: 414 HILIW 418 +L+W Sbjct: 692 RVLLW 696 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 32/132 (24%), Positives = 49/132 (37%), Gaps = 6/132 (4%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 D Y+ L+ A +HP + VA GS + LW+ + + G G Sbjct: 615 DHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSADRTVRLWD--VLNGNCVRIFTGHKGP 671 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 I L F+P N + +G L D G+ L V + CSL S ++ + Sbjct: 672 IHSLTFSP-NGRFLATGATDGRVLLWDI-GHGLMVGELKGHTDT-VCSLRFSRDGEILAS 728 Query: 219 GDNVGNVILLNM 230 G V L + Sbjct: 729 GSMDNTVRLWDA 740 >6F3T-A nrPDB Length = 608 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 80/217 (36%), Gaps = 15/217 (6%) Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 G G + G F+P + N +SS +GT RL + V +W S Sbjct: 348 YGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW--DTQFSPY 404 Query: 213 SRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 V+G + L D + L H V +P ++ +AT S D+TV++WD Sbjct: 405 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSADRTVRLWD 463 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 + + G +++ H+ P+++ FSP+G L T + ++ L H Sbjct: 464 V--LNGNCVRIFT-GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 520 Query: 332 RHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYE 368 T + ++ G D + + Sbjct: 521 ------TVCSLRFSRDGEILASGS-MDNTVRLWDAIK 550 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 45/256 (17%), Positives = 90/256 (35%), Gaps = 25/256 (9%) Query: 67 RSIVRTLHQHKLGRASWPSVQQGLQQSF---LHTLDSYRILQKAAPFDRRATSLAWHPTH 123 RS+ + + + S +++ + + L L + A F Sbjct: 313 RSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASF----------SPD 362 Query: 124 PSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL 183 + + S+ G + LW+ ++ + G + +F+P F + + RL Sbjct: 363 RNYLLSSSEDGTVRLWS--LQTFTCLVGYKGHNYPVWDTQFSPYGY-YFVSGGHDRVARL 419 Query: 184 QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHK 242 + ++ +S V TG V L ++ +G + HK Sbjct: 420 WATDHYQPLRIFAGHLADV--NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHK 477 Query: 243 KKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNAACFSPDGA 301 + + +P + LAT + D V +WD+ G + L H V + FS DG Sbjct: 478 GPIHSLTFSPNGRF-LATGATDGRVLLWDI----GHGLMVGELKGHTDTVCSLRFSRDGE 532 Query: 302 RLLTTDQKSEIRVYSA 317 L + + +R++ A Sbjct: 533 ILASGSMDNTVRLWDA 548 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 46/274 (16%), Positives = 92/274 (33%), Gaps = 42/274 (15%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSL 207 F + A +T + +++ + T R+ LR S+ Sbjct: 270 CFYTFLNAYQGLTAVDVT-DDSSLIAGGFADSTVRVWSVTPKKLR-------------SV 315 Query: 208 DVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQT 266 ++ ++ + +++ EL L H V + +P ++ L ++S D T Sbjct: 316 KQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLL-SSSEDGT 374 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 V++W L+ + H +PV FSP G ++ R+++ + Sbjct: 375 VRLWSLQTFTC---LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF 431 Query: 327 IPHPHRHFQHLTPIKAA-WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQ 385 HL + +HP N + G D + + +F G+ G + Sbjct: 432 AG-------HLADVNCTRFHPNSNYVATGSA-DRTVRLWDVLNGNCVRIFTGHKGPIHSL 483 Query: 386 LYDPESSGISSLNEFNPMGDTLASAMGY-HILIW 418 F+P G LA+ +L+W Sbjct: 484 T-------------FSPNGRFLATGATDGRVLLW 504 >4A11-B nrPDB Length = 408 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 120/317 (37%), Gaps = 37/317 (11%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK-------GIGAGG----S 158 +L P + G G I+L++ + ++ G S Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKG-NILRVFASSDTINIWFCSLDVSASSRMVV 217 + +++ P +T F +SS + T ++ D VF +T+ S VS +V Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMS-PVSTKHCLVA 160 Query: 218 TGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 G V L ++ G L+ H++++ V+ +P D+ LATAS D VK+WD+R+ Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 Query: 277 G-------------KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323 G +A + H VN CF+ DG LLT + +R++++S + Sbjct: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 Query: 324 LG----LIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNS 379 L + + + + + + + G T Y I + G+ Sbjct: 281 LVNYGKVCNNSKKGLKFT--VSCGCSSEFVFVPYGS----TIAVYTVYSGEQITMLKGHY 334 Query: 380 GKMMCQLYDPESSGISS 396 + C ++ + S Sbjct: 335 KTVDCCVFQSNFQELYS 351 Score = 62.2 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 36/273 (13%), Positives = 74/273 (27%), Gaps = 33/273 (12%) Query: 72 TLHQHKLGRASWPSVQQGLQQSFLH--TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAV 129 H V G + + L S + +++W P + +A Sbjct: 145 YSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILAT 204 Query: 130 GSKGGDIMLWNFGIKDKPTFIK---------------GIGAGGSITGLKFNPLNTNQFYA 174 S + LW+ I G + GL F + Sbjct: 205 ASADSRVKLWDVRRASG-CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV 263 Query: 175 SSMEGTTRLQDFKGNILRVFASS----DTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 230 + + RL + + ++ ++ SS V + Sbjct: 264 GT-DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVY 322 Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW--DLRQVRGKASFLYSLPHR 288 G+++ L+ H K V L + S D + W L + + Sbjct: 323 SGEQITMLKGHYKTVDCCVFQSNFQE-LYSGSRDCNILAWVPSLYEPVPDDDETTTKSQL 381 Query: 289 HPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 321 +P +S ++D++ +S Q++ Sbjct: 382 NPAFEDAWS-------SSDEEGGTSAWSHPQFE 407 >5M25-A nrPDB Length = 434 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 103/269 (38%), Gaps = 27/269 (10%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G +++ +KF+P N +SS + ++ S + I + S+ S Sbjct: 143 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDVAWSSDS 199 Query: 214 RMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 ++V+ + + + ++ GK L L+ H V NP + + + S D++V+IWD+ Sbjct: 200 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDV 258 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 + + + H PV+A F+ DG+ ++++ R++ + C LI + Sbjct: 259 KTGKCLKTLP---AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN- 314 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESS 392 P+ ++ D K + + + + G+ + C Sbjct: 315 -----PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI------- 362 Query: 393 GISSLNEFNPMGDT-LASAMGYH-ILIWS 419 F+ G + S + + IW+ Sbjct: 363 ----FANFSVTGGKWIVSGSEDNLVYIWN 387 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 44/267 (16%), Positives = 94/267 (35%), Gaps = 22/267 (8%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 + + + +AW + + S + +W+ + G + F Sbjct: 181 KTISGHKLGISDVAWSSDS-NLLVSASDDKTLKIWD--VSSGKCLKTLKGHSNYVFCCNF 237 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 NP +N + S + + R+ D K + + ++ + ++V+ G Sbjct: 238 NPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGL 294 Query: 225 VILLN-MDGKELWNLRMHKK-KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFL 282 + + G+ L L V+ V +P + LA A++D T+K+WD +GK Sbjct: 295 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYS--KGKCLKT 351 Query: 283 YSLPHRHPVNAACFS---PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 Y+ H++ + G +++ + + + +++ + L H Sbjct: 352 YT-GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD------VV 404 Query: 340 IKAAWHPRYNLIVVGRYP-DPNFKSCT 365 I A HP N+I D K Sbjct: 405 ISTACHPTENIIASAALENDKTIKLWK 431 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 34/161 (21%), Positives = 69/161 (42%), Gaps = 11/161 (6%) Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 + L H K V+ V +P +W LA++S D+ +KIW + + + H+ ++ Sbjct: 139 FTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTIS---GHKLGISDVA 194 Query: 296 FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGR 355 +S D L++ ++++ S C L H + F ++P+ NLIV G Sbjct: 195 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF------CCNFNPQSNLIVSGS 248 Query: 356 YPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 + D + + + + +S + ++ + S I S Sbjct: 249 F-DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 288 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 19/193 (9%), Positives = 52/193 (26%), Gaps = 20/193 (10%) Query: 49 DSDCLWVGLAGPQILP------PCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYR 102 +S +W G + P ++ + +S+ + + + S + Sbjct: 251 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA------SGQ 304 Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 L+ D S + + + + LW++ G + Sbjct: 305 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--KGKCLKTYTGHKNEKYCI 362 Query: 163 --KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG- 219 F+ + S + + + + + T S + ++ + Sbjct: 363 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT--DVVISTACHPTENIIASAA 420 Query: 220 -DNVGNVILLNMD 231 +N + L D Sbjct: 421 LENDKTIKLWKSD 433 >2H9P-A nrPDB Length = 329 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 103/269 (38%), Gaps = 27/269 (10%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G +++ +KF+P N +SS + ++ S + I + S+ S Sbjct: 38 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDVAWSSDS 94 Query: 214 RMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 ++V+ + + + ++ GK L L+ H V NP + + + S D++V+IWD+ Sbjct: 95 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDV 153 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 + + + H PV+A F+ DG+ ++++ R++ + C LI + Sbjct: 154 KTGKCLKTLP---AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN- 209 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESS 392 P+ ++ D K + + + + G+ + C Sbjct: 210 -----PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI------- 257 Query: 393 GISSLNEFNPMGDT-LASAMGYH-ILIWS 419 F+ G + S + + IW+ Sbjct: 258 ----FANFSVTGGKWIVSGSEDNLVYIWN 282 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 44/267 (16%), Positives = 94/267 (35%), Gaps = 22/267 (8%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 + + + +AW + + S + +W+ + G + F Sbjct: 76 KTISGHKLGISDVAWSSDS-NLLVSASDDKTLKIWD--VSSGKCLKTLKGHSNYVFCCNF 132 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 NP +N + S + + R+ D K + + ++ + ++V+ G Sbjct: 133 NPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGL 189 Query: 225 VILLN-MDGKELWNLRMHKK-KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFL 282 + + G+ L L V+ V +P + LA A++D T+K+WD +GK Sbjct: 190 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYS--KGKCLKT 246 Query: 283 YSLPHRHPVNAACFS---PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 Y+ H++ + G +++ + + + +++ + L H Sbjct: 247 YT-GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD------VV 299 Query: 340 IKAAWHPRYNLIVVGRYP-DPNFKSCT 365 I A HP N+I D K Sbjct: 300 ISTACHPTENIIASAALENDKTIKLWK 326 Score = 111 bits (276), Expect = 8e-25, Method: Composition-based stats. Identities = 34/161 (21%), Positives = 69/161 (42%), Gaps = 11/161 (6%) Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 + L H K V+ V +P +W LA++S D+ +KIW + + + H+ ++ Sbjct: 34 FTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTIS---GHKLGISDVA 89 Query: 296 FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGR 355 +S D L++ ++++ S C L H + F ++P+ NLIV G Sbjct: 90 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF------CCNFNPQSNLIVSGS 143 Query: 356 YPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 + D + + + + +S + ++ + S I S Sbjct: 144 F-DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 183 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 19/193 (9%), Positives = 52/193 (26%), Gaps = 20/193 (10%) Query: 49 DSDCLWVGLAGPQILP------PCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYR 102 +S +W G + P ++ + +S+ + + + S + Sbjct: 146 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA------SGQ 199 Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 L+ D S + + + + LW++ G + Sbjct: 200 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--KGKCLKTYTGHKNEKYCI 257 Query: 163 --KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG- 219 F+ + S + + + + + T S + ++ + Sbjct: 258 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT--DVVISTACHPTENIIASAA 315 Query: 220 -DNVGNVILLNMD 231 +N + L D Sbjct: 316 LENDKTIKLWKSD 328 >6GMH-W nrPDB Length = 305 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 113/300 (37%), Gaps = 20/300 (6%) Query: 103 ILQKAAPFDRRATSLAW---HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSI 159 + ++ D S+AW + TV GS + +W + + G + Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGV 67 Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG 219 + + +SS++ RL D + + ++ W +L S S+ + TG Sbjct: 68 VSVDIS-HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAW--TLAFSPDSQYLATG 124 Query: 220 DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 +VG V + + GK+ ++L K + +A +P + LA+ ++D + I+D+ Sbjct: 125 THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIFDI----AT 179 Query: 279 ASFLYSL-PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 L++L H P+ + FSPD L+T I++Y + L H Sbjct: 180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA------- 232 Query: 338 TPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSL 397 + + + V D + K + F + ++ Y+ S I S+ Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSV 292 >1VYH-C nrPDB Length = 410 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 48/311 (15%), Positives = 106/311 (34%), Gaps = 38/311 (12%) Query: 107 AAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNP 166 + T + +HP S + S+ I +W++ + G S+ + F+ Sbjct: 104 LSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDY--ETGDFERTLKGHTDSVQDISFD- 159 Query: 167 LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 + + S + T +L DF+G N+ S+ + + +V+ + Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV--SSVSIMPNGDHIVSASRDKTIK 217 Query: 227 LLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 + + G + H++ V V N +A+ S DQTV++W + KA Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGT-LIASCSNDQTVRVWVVATKECKAELR--- 273 Query: 286 PHRHPVNAACFSPD--------------------GARLLTTDQKSEIRVYSASQWDCPLG 325 HRH V ++P+ G LL+ + I+++ S C + Sbjct: 274 EHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333 Query: 326 LIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQ 385 L+ H + ++ ++ D + R + + + + Sbjct: 334 LVGHDN-------WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386 Query: 386 LYDPESSGISS 396 + + + + Sbjct: 387 DFHKTAPYVVT 397 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 103/290 (35%), Gaps = 37/290 (12%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G +T + F+P+ + ++S + T ++ D++ T ++ + S Sbjct: 106 GHRSPVTRVIFHPVFSVM-VSASEDATIKVWDYETGDFERTLKGHTDSV--QDISFDHSG 162 Query: 214 RMVVTGDNVGNVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 +++ + + L + G + + + H V+ V++ P D + +AS D+T+K+W++ Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGD-HIVSASRDKTIKMWEV 221 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH--- 329 + +F HR V + DG + + +RV+ + +C L H Sbjct: 222 QTGYCVKTFT---GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHV 278 Query: 330 -------PHRHFQHLTPIKAAWHPRYN----LIVVGRYPDPNFKSCTPYELRTIDVFDGN 378 P + ++ + + ++ G D K + G+ Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSR-DKTIKMWDVSTGMCLMTLVGH 337 Query: 379 SGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQEEARTRK 427 + L F+ G + S + +W + R K Sbjct: 338 DNWVRGVL-------------FHSGGKFILSCADDKTLRVWDYKNKRCMK 374 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 34/238 (14%), Positives = 76/238 (31%), Gaps = 27/238 (11%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + ++ D +S++ P + S+ I +W ++ G Sbjct: 179 FQGFECIRTMHGHDHNVSSVSIMPN-GDHIVSASRDKTIKMWE--VQTGYCVKTFTGHRE 235 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS----- 212 + ++ N T + S + T R+ + + S +S Sbjct: 236 WVRMVRPNQDGT-LIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSIS 294 Query: 213 -------------SRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFL 258 +++G + + ++ G L L H V V + + L Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFIL 354 Query: 259 ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 + A D+T+++WD + R + H H V + F ++T ++V+ Sbjct: 355 SCAD-DKTLRVWDYKNKRCMKTLN---AHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 64/192 (33%), Gaps = 25/192 (13%) Query: 228 LNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287 E + L H+ VT V +P + +AS D T+K+WD + + H Sbjct: 94 WIPRPPEKYALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTLK---GH 149 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 347 V F G L + I+++ ++C + H H +++ + P Sbjct: 150 TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH----NVSSVSIM--PN 203 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 407 + IV D K + F G+ + ++ P G + Sbjct: 204 GDHIVSASR-DKTIKMWEVQTGYCVKTFTGHREWV--RMVRPNQD-----------GTLI 249 Query: 408 ASAMGYH-ILIW 418 AS + +W Sbjct: 250 ASCSNDQTVRVW 261 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 60/171 (35%), Gaps = 25/171 (14%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT------------- 169 + +A S + +W + K + + + + P ++ Sbjct: 245 DGTLIASCSNDQTVRVW--VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETK 302 Query: 170 ------NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVG 223 + S + T ++ D + + + W + + + +++ + Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH--DNWVRGVLFHSGGKFILSCADDK 360 Query: 224 NVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 + + + + + L H+ VT + + ++ T SVDQTVK+W+ R Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFH-KTAPYVVTGSVDQTVKVWECR 410 Score = 34.1 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 33/107 (30%), Gaps = 19/107 (17%) Query: 317 ASQWDCPLGLIPHPHRHFQ---HLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTI 372 Q P IP P + H +P+ +HP ++++V D K Sbjct: 85 LGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSAS-EDATIKVWDYETGDFE 143 Query: 373 DVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY-HILIW 418 G++ + F+ G LAS I +W Sbjct: 144 RTLKGHTDSVQDI-------------SFDHSGKLLASCSADMTIKLW 177 >6HHQ-h nrPDB Length = 319 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 54/309 (17%), Positives = 98/309 (31%), Gaps = 57/309 (18%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD---KPTFIKGIGAGGSITGL 162 + TSLA P+ + S+ ++ W D G + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 222 ++S + T RL D ++ S+D+ + M+++G Sbjct: 72 TLTADGA-YALSASWDKTLRLWDVATGETYQRFVGHKSDV--MSVDIDKKASMIISGSRD 128 Query: 223 GNVILLNMDGKELWNLRMHKKKVTHVALNP-----CCDWFLATASVDQTVKIWDLRQVRG 277 + + + G+ L L H V+ V + P + +A D+ VK W+L Q + Sbjct: 129 KTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQI 188 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS---------ASQWDCPLGLIP 328 +A F + H +N SPDG + + + EI +++ S D L Sbjct: 189 EADF---IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAF 245 Query: 329 HPHRHF--------------------QHLTP-------------IKAAWHPRYNLIVVGR 355 P+R++ L P + AW + G Sbjct: 246 SPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAG- 304 Query: 356 YPDPNFKSC 364 Y D + Sbjct: 305 YTDNVIRVW 313 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 62/186 (33%), Gaps = 18/186 (9%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR---QVRGKASFLYSLPHRHPVNA 293 L H VT +A + L +AS D+T+ W L Q G + H H V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFK-GHSHIVQD 70 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 + DGA L+ +R++ + + + H + + + + +++ Sbjct: 71 CTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHK-------SDVMSVDIDKKASMII 123 Query: 354 GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY 413 D K T + + + G++ + P + +++ Sbjct: 124 SGSRDKTIKVWT-IKGQCLATLLGHNDWVSQVRVVPNEK------ADDDSVTIISAGNDK 176 Query: 414 HILIWS 419 + W+ Sbjct: 177 MVKAWN 182 >6HQA-B nrPDB Length = 722 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 58/321 (18%), Positives = 109/321 (33%), Gaps = 38/321 (11%) Query: 65 PCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHP 124 P +S + + + S ++ Q+ L ++ Y + T L ++ Sbjct: 348 PLKSAQDLRNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNT----NNDLTCLKFN-DDS 402 Query: 125 STVAVGSKGGDIMLWNFGIKDKPTFIKG-------------------IGAGGSITGLKFN 165 + VA G + I LW+ + +K +G G++ G+ F+ Sbjct: 403 TMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFS 462 Query: 166 PLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV 225 P N + S + T RL V + ++W + S T + Sbjct: 463 PDNR-YLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVW--DVKFSPMGHYFATASHDQTA 519 Query: 226 ILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284 L + D L H V V +P + T S D+T ++WD+ RG+ ++ Sbjct: 520 RLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF-TGSSDKTARMWDI--ARGECVRVF- 575 Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAW 344 + H +N SPDG L + + S + ++ S + H L Sbjct: 576 MGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLA------ 629 Query: 345 HPRYNLIVVGRYPDPNFKSCT 365 R ++V D + + Sbjct: 630 FSREGTVLVSTGADNSVRVWD 650 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 41/228 (17%), Positives = 85/228 (37%), Gaps = 12/228 (5%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 ++ + + P + S+ + LW+ + G S+ +KF Sbjct: 447 RRLVGHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLDTYT--CLVSYKGHSSSVWDVKF 503 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 +P+ F +S + T RL + ++ ++ +S + TG + Sbjct: 504 SPMGH-YFATASHDQTARLWSCDHIYPLRIFAGHLNDV--DCVEFHPNSTYLFTGSSDKT 560 Query: 225 VILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 + ++ G+ + H + +A++P W LA+A D V +WD+ R Sbjct: 561 ARMWDIARGECVRVFMGHSGAINCLAVSPDGRW-LASAGEDSVVCLWDISTGR---RIKA 616 Query: 284 SLPH-RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 H R + + FS +G L++T + +RV+ + P P Sbjct: 617 MRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEP 664 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 93/296 (31%), Gaps = 53/296 (17%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCS- 206 +T LKFN ++ + + +L G+ LR +D N Sbjct: 382 CMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 207 ------------------LDVSASSRMVVTGDNVGNVILLNMDGK-ELWNLRMHKKKVTH 247 +D S +R +++ V L ++D L + + H V Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWD 500 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL----PHRHPVNAACFSPDGARL 303 V +P +F ATAS DQT ++W +Y L H + V+ F P+ L Sbjct: 501 VKFSPMGHYF-ATASHDQTARLW-------SCDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 304 LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKS 363 T R++ ++ +C + H A P + D Sbjct: 553 FTGSSDKTARMWDIARGECVRVFMGHSGAIN------CLAVSPDGRWLASAG-EDSVVCL 605 Query: 364 CTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLAS-AMGYHILIW 418 R I G+ S I SL F+ G L S + +W Sbjct: 606 WDISTGRRIKAMRGHGR-----------SSIYSL-AFSREGTVLVSTGADNSVRVW 649 Score = 51.4 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 32/93 (34%), Gaps = 5/93 (5%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS-ITGLKFNPLN 168 LA P +A + + LW+ I G G S I L F+ Sbjct: 578 HSGAINCLAVSPD-GRWLASAGEDSVVCLWD--ISTGRRIKAMRGHGRSSIYSLAFSREG 634 Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTIN 201 T ++ + + R+ D K N A + IN Sbjct: 635 T-VLVSTGADNSVRVWDVKKNTNSPSAQPEPIN 666 >6G51-g nrPDB Length = 317 Score = 155 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 96/291 (32%), Gaps = 26/291 (8%) Query: 89 GLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVA---------VGSKGGDIMLW 139 L S T+ +++ + + +L H S V GS G + LW Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90 Query: 140 NFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDT 199 + + T + +G + + F+ N Q + S + T +L + G Sbjct: 91 D--LTTGTTTRRFVGHTKDVLSVAFSSDNR-QIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 Query: 200 INIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDW 256 W + S S+ ++V+ V + N+ +L H + V ++P Sbjct: 148 SE-WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS- 205 Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 A+ D +WDL + LY+L +NA CFSP+ L I+++ Sbjct: 206 LCASGGKDGQAMLWDLN----EGKHLYTLDGGDIINALCFSPNRYWLCAATGP-SIKIWD 260 Query: 317 ASQWDCPLGLIPHPHRHFQHLTPIKA---AWHPRYNLIVVGRYPDPNFKSC 364 L P + AW + G Y D + Sbjct: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG-YTDNLVRVW 310 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 110/327 (33%), Gaps = 46/327 (14%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD---KPTFIKGIGAGGSITGLKFNP 166 + T +A P P + S+ I++W + G ++ + + Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 Query: 167 LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 + S +GT RL D T ++ S+ S+ +R +V+G + Sbjct: 74 DGQ-FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV--LSVAFSSDNRQIVSGSRDKTIK 130 Query: 227 LLNMDGKELWNLR--MHKKKVTHVALNPCC-DWFLATASVDQTVKIWDLRQVRGKASFLY 283 L N G + ++ H + V+ V +P + + + D+ VK+W+L + K + Sbjct: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH-- 188 Query: 284 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS---------ASQWDCPLGLIPHPHRHF 334 + H +N SPDG+ + + + ++ D L P+R++ Sbjct: 189 -IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW 247 Query: 335 QHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE-SSG 393 + P+ K +D + P+ +S Sbjct: 248 ------------------LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSL 289 Query: 394 ISSLNEFNPMGDTLASAMGYH-ILIWS 419 S + G TL + + + +W Sbjct: 290 AWSAD-----GQTLFAGYTDNLVRVWQ 311 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 64/186 (34%), Gaps = 20/186 (10%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL--PHRHPVNAA 294 L+ H VT +A P + +AS D+T+ +W L + H H V+ Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 295 CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 354 S DG L+ +R++ + + H + A+ IV G Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDV------LSVAFSSDNRQIVSG 123 Query: 355 RYPDPNFKSCTPYELRTIDVFDG-NSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY 413 D K + V D +S + C + P SS NP+ ++ Sbjct: 124 SR-DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS--------NPI--IVSCGWDK 172 Query: 414 HILIWS 419 + +W+ Sbjct: 173 LVKVWN 178 >2HES-X nrPDB Length = 330 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 44/225 (19%), Positives = 75/225 (33%), Gaps = 29/225 (12%) Query: 208 DVSASSRMVVTGDNVGNVILLNMDGKELWNLR-----MHKKKVTHVALNPCCDWFLATAS 262 S ++ TG + L+++ + + HKK + VA P LA S Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTS-LLAAGS 77 Query: 263 VDQTVKIWDLRQVRGKASFLYSL-----PHRHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 D TV IW ++ +F L H + V +S DG L T + + ++ Sbjct: 78 FDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWET 136 Query: 318 SQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY--ELRTIDVF 375 + I H Q + + WHP L+ Y D + Y + + V Sbjct: 137 DESGEEYECISVLQEHSQDVKHV--IWHPSEALLASSSYDD-TVRIWKDYDDDWECVAVL 193 Query: 376 DGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWS 419 +G+ G + +D L S + +W Sbjct: 194 NGHEGTVWSSDFDKTEGVF-----------RLCSGSDDSTVRVWK 227 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 105/322 (32%), Gaps = 44/322 (13%) Query: 127 VAVGSKGGDIMLWNFGIKDKPT--FIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ 184 +A GS I L + D + +I + + P T+ A S + T + Sbjct: 27 LATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPH-TSLLAAGSFDSTVSIW 85 Query: 185 DFKGNILRVF-----ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK-----E 234 + + R F A + + S + T +V + D Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 294 + L+ H + V HV +P + LA++S D TV+IW + + + H V ++ Sbjct: 146 ISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVAVLN-GHEGTVWSS 203 Query: 295 CFSPDGA--RLLTTDQKSEIRVY--------SASQWDCPLGLIPHPHRHFQHLTPIKAAW 344 F RL + S +RV+ +W C L P H + + + AW Sbjct: 204 DFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAIL---PDVHKRQVYNV--AW 258 Query: 345 HPRYNLIVVGRYPDPNFKSCTPYE--LRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNP 402 ++ D + + + +Y+ LN Sbjct: 259 GFNG--LIASVGADGVLAVYEEVDGEWKVFA-----KRALCHGVYEINVVKWLELNG--- 308 Query: 403 MGDTLASAMGYHIL-IWSQEEA 423 LA+ I+ WS E+A Sbjct: 309 -KTILATGGDDGIVNFWSLEKA 329 Score = 61.4 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 40/284 (14%), Positives = 84/284 (29%), Gaps = 46/284 (16%) Query: 39 AKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTL 98 AK R + D L + + G + + + + + L S + + Sbjct: 86 AKEESADRTFEMDLLAI-IEGHE--NEVKGVAWSNDGYYLATCS--RDKSVWIWETDESG 140 Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 + Y + + + WHP+ + +A S + +W D G G+ Sbjct: 141 EEYECISVLQEHSQDVKHVIWHPSE-ALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGT 199 Query: 159 ITGLKFNP-LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + F+ + + S + T R+ + G+ D W + Sbjct: 200 VWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGD------DEDDQQEWV-CEAILPDV---- 248 Query: 218 TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 277 HK++V +VA +A+ D + +++ Sbjct: 249 -----------------------HKRQVYNVAWGFNG--LIASVGADGVLAVYEEVDGEW 283 Query: 278 KASFLYSLPHRH-PVNAACF-SPDGAR-LLTTDQKSEIRVYSAS 318 K +L H +N + +G L T + +S Sbjct: 284 KVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLE 327 >4V6W-Ag nrPDB Length = 318 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 54/314 (17%), Positives = 103/314 (32%), Gaps = 53/314 (16%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLW----NFGIKDKPTFIKGIG 154 ++ ++ + T +A +P P T+ S+ +++W + + G Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 155 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 214 I+ + + N + S + T RL D T ++ S+ SA +R Sbjct: 63 HSHFISDVVLSSDG-NYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDV--LSVAFSADNR 119 Query: 215 MVVTGDNVGNVILLNMDGKELWNLR--MHKKKVTHVALNPC-CDWFLATASVDQTVKIWD 271 +V+G + L N + + ++ H V+ V +P + + + D+TVK+W+ Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 272 LRQVRGK--------------------------------------ASFLYSLPHRHPVNA 293 L + K LY+L H +NA Sbjct: 180 LANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINA 239 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA---AWHPRYNL 350 CFSP+ L I+++ + L P + AW Sbjct: 240 LCFSPNRYWLCVA-YGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQT 298 Query: 351 IVVGRYPDPNFKSC 364 + G Y D + Sbjct: 299 LFAG-YSDNTIRVW 311 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 99/261 (37%), Gaps = 21/261 (8%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 125 +V + + SW + L L + + ++ + S+A+ Sbjct: 67 ISDVVLSSDGNYALSGSWDQTLR------LWDLAAGKTTRRFEGHTKDVLSVAFS-ADNR 119 Query: 126 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTN-QFYASSMEGTTRLQ 184 + GS+ I LWN + K T + G ++ ++F+P ++N + + T ++ Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 185 DFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKK 243 + L+ N + ++ VS + +G +L ++ DGK L+ L H Sbjct: 179 NLANCKLKNNHHGH--NGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HND 235 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDL------RQVRGKASFLYSLPHRHPVNAACFS 297 + + +P W ++KIWDL ++R + S + + +S Sbjct: 236 IINALCFSPNRYWLCVAYG--PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWS 293 Query: 298 PDGARLLTTDQKSEIRVYSAS 318 DG L + IRV+ S Sbjct: 294 TDGQTLFAGYSDNTIRVWQVS 314 >3DM0-A nrPDB Length = 694 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 42/243 (17%), Positives = 89/243 (36%), Gaps = 23/243 (9%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD---KPTFIKGIGAGGSITGLKFN 165 T++A + + S+ I+LW D + G + + + Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 166 PLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV 225 + S +G RL D + T ++ S+ S +R +V+ + Sbjct: 440 SDGQ-FALSGSWDGELRLWDLAAGVSTRRFVGHTKDV--LSVAFSLDNRQIVSASRDRTI 496 Query: 226 ILLNMDGKELWNL----RMHKKKVTHVALNPCC-DWFLATASVDQTVKIWDLRQVRGKAS 280 L N G+ + + H+ V+ V +P + +AS D+TVK+W+L + +++ Sbjct: 497 KLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRST 556 Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW---------DCPLGLIPHPH 331 H V+ SPDG+ + + + ++ ++ L P+ Sbjct: 557 L---AGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPN 613 Query: 332 RHF 334 R++ Sbjct: 614 RYW 616 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 95/274 (34%), Gaps = 37/274 (13%) Query: 69 IVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVA 128 +V + SW + L L + ++ + S+A+ + Sbjct: 436 VVLSSDGQFALSGSWDGELR------LWDLAAGVSTRRFVGHTKDVLSVAFS-LDNRQIV 488 Query: 129 VGSKGGDIMLWNFGIKDKPTFIK----GIGAGGSITGLKFNPLN-TNQFYASSMEGTTRL 183 S+ I LWN G G ++ ++F+P ++S + T ++ Sbjct: 489 SASRDRTIKLWN---TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 184 QDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHK 242 + LR + T + ++ VS + +G G V+L ++ +GK+L++L Sbjct: 546 WNLSNCKLRSTLAGHT--GYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-N 602 Query: 243 KKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP------------ 290 + + +P W A + + +KIWDL L Sbjct: 603 SVIHALCFSPNRYWLCA--ATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKR 660 Query: 291 ----VNAACFSPDGARLLTTDQKSEIRVYSASQW 320 + +S DG+ L + IRV+ ++ Sbjct: 661 KVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGRY 694 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 65/196 (33%), Gaps = 24/196 (12%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR---GKASFLYSLPHRHPVNA 293 +R H VT +A + +AS D+++ +W L + G A + H H V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLT-GHSHFVED 435 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 S DG L+ E+R++ + + H + A+ IV Sbjct: 436 VVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDV------LSVAFSLDNRQIVS 489 Query: 354 GRYPDPNFKSCTPYELRTIDVFDGNSG---KMMCQLYDPESSGISSLNEFNPMGDTLASA 410 D K + +G G + C + P N P ++++ Sbjct: 490 ASR-DRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSP--------NTLQPT--IVSAS 538 Query: 411 MGYHILIWSQEEARTR 426 + +W+ + R Sbjct: 539 WDKTVKVWNLSNCKLR 554 >5FVM-C nrPDB Length = 303 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 86/227 (37%), Gaps = 16/227 (7%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 TS+A+ + S+ G I +W+ P+ + + + +P N Sbjct: 74 HKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVR---SPSVQRNYKHNAPVNEVAIHP-NQ 128 Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 + + +G R+ D N + + N SL V++ M+V G+N GN + Sbjct: 129 GELISCDQDGNIRIWDLGENQCTNQLTPED-NTPLQSLSVASDGSMLVAGNNKGNCYVWR 187 Query: 230 MDGKE-------LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFL 282 M + + H K +T V L+ LAT S D T ++W++ + L Sbjct: 188 MPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARVWNIEDNYQLETTL 246 Query: 283 YSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 H+ V FS D A L+T +R++ S + H Sbjct: 247 D--GHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGH 291 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 93/284 (32%), Gaps = 42/284 (14%) Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228 + ++ + T R + + + L++++ + + ++ V L Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTI--QHADSQVNRLEITSDKKYLAAAGHLH-VRLY 58 Query: 229 NMDGKE---LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 ++ + + HK VT +A W + ++S D T+K+WD+R S + Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAFQQENRW-MVSSSEDGTIKVWDVRS----PSVQRNY 113 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK---- 341 H PVN P+ L++ DQ IR++ + C L P + Q L+ Sbjct: 114 KHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSM 173 Query: 342 ----------AAWHPRYNLIVVGRYPDPNFKSCTPYELR-----------------TIDV 374 W ++ P FKS T Y R T V Sbjct: 174 LVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARV 233 Query: 375 FDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIW 418 ++ + D + + + +++ +W Sbjct: 234 WNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLW 277 Score = 64.9 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 48/136 (35%), Gaps = 9/136 (6%) Query: 122 THPSTVAVGSKGGDIMLWNFGIKDKPTFI----KGIGAGGSITGLKFNPLNTNQFYASSM 177 + S + G+ G+ +W + + K IT + + N S Sbjct: 169 SDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSA 227 Query: 178 EGTTRLQDFKGN-ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-L 235 + T R+ + + N L +W C SA S +VT + V L ++ E + Sbjct: 228 DHTARVWNIEDNYQLETTLDGHQRWVWDC--AFSADSAYLVTACSDHYVRLWDLSTSEIV 285 Query: 236 WNLRMHKKKVTHVALN 251 H K VALN Sbjct: 286 RQYGGHHKGAVCVALN 301 >6QX9-4B nrPDB Length = 522 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 110/340 (32%), Gaps = 39/340 (11%) Query: 92 QSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK 151 Q +L S DR + + P +A G LW+ + Sbjct: 212 QELHKSLRSLNNFCSQIGDDRPISYCHFSPNS-KMLATACWSGLCKLWSVPDCN--LLHT 268 Query: 152 GIGAGGSITGLKFNPLNTNQF-------YASSMEGTTRLQDFKGNILRVFASSDTINIWF 204 G ++ + F+P +T + + +G+ +L + T+ + Sbjct: 269 LRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRV-- 326 Query: 205 CSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASV 263 + S R + T + L +++ +E + + H V +A + T + Sbjct: 327 ARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS-LAGTGGL 385 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323 D ++WDLR R ++ H + FSP+G + T + +V+ Q C Sbjct: 386 DAFGRVWDLRTGRC---IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCV 442 Query: 324 LGLIPHPHRHF-QHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 + H + PI N ++ G Y D K T + G+ GK+ Sbjct: 443 YTIPAHQNLVTGVKFEPIH------GNFLLTGAY-DNTAKIWTHPGWSPLKTLAGHEGKV 495 Query: 383 MCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQE 421 M + G +A+ +W E Sbjct: 496 MGLDI-------------SSDGQLIATCSYDRTFKLWMAE 522 >5FL8-q nrPDB Length = 515 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 63/399 (15%), Positives = 126/399 (31%), Gaps = 86/399 (21%) Query: 71 RTLHQHKLGRA-SWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAV 129 T + G + + Q+ +HTL + ++W P +A Sbjct: 154 HTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYN---------WVLCVSWSPD-GEVIAT 203 Query: 130 GSKGGDIMLWNFGIKDKPTFI-KGIGAGGSITGLKFNPL------NTNQFYASSMEGTTR 182 GS I LW+ K G IT L + P+ + + +SS +GT + Sbjct: 204 GSMDNTIRLWDP--KSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIK 261 Query: 183 LQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD--GKELWNLRM 240 + D + + S T ++ + ++ +G + V + +++ G+ + L+ Sbjct: 262 IWDTVSRVCQYTMSGHTNSV--SCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKS 318 Query: 241 HKKKVTHVALNPC--------------------------------------CDWFLATAS 262 H V H++L+ + + TAS Sbjct: 319 HAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTAS 378 Query: 263 VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322 D T+ +W ++ H+ VN FSPDG +++ + I+++ Sbjct: 379 DDYTMFLW--NPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKF 436 Query: 323 PLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 H +Q AW L+V D K + G+ ++ Sbjct: 437 ISTFRGHVASVYQ------VAWSSDCRLLVSCS-KDTTLKVWDVRTRKLSVDLPGHKDEV 489 Query: 383 MCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQ 420 S++ G + S + +W+ Sbjct: 490 YTVD--------WSVD-----GKRVCSGGKDKMVRLWTH 515 Score = 128 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 104/302 (34%), Gaps = 38/302 (12%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G +I F P +++ + + T R+ D W + S Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGH--YNWVLCVSWSPDG 198 Query: 214 RMVVTGDNVGNVILLNMD-GKEL-WNLRMHKKKVTHVAL------NPCCDWFLATASVDQ 265 ++ TG + L + G+ L LR H K +T ++ P LA++S D Sbjct: 199 EVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDG 258 Query: 266 TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA-SQWDCPL 324 T+KIWD V + S H + V+ + G L + +RV+ SQ C Sbjct: 259 TIKIWD--TVSRVCQYTMS-GHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCIN 314 Query: 325 GLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT--PYELRTIDVFDGNSGKM 382 L H H HL+ G+ P ++ I +GNS +M Sbjct: 315 ILKSHAH-WVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEM 373 Query: 383 MCQLYDPESSGISSLNE-------------------FNPMGDTLASAMGYH-ILIWSQEE 422 M D + + + + F+P G + SA + I +W + Sbjct: 374 MVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRD 433 Query: 423 AR 424 + Sbjct: 434 GK 435 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 32/193 (16%), Positives = 60/193 (31%), Gaps = 29/193 (15%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPV 291 + + H + A P + T + D T +IWD + +++L H + V Sbjct: 134 RSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC----DTQTPMHTLKGHYNWV 189 Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCP-LGLIPH----PHRHFQHLTPIKAAWHP 346 +SPDG + T + IR++ C L H ++ + +K P Sbjct: 190 LCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKP 249 Query: 347 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT 406 R + D K G++ + C + + Sbjct: 250 R----LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG--------------L 291 Query: 407 LASAMGYH-ILIW 418 L S + +W Sbjct: 292 LYSGSHDRTVRVW 304 >3JAP-g nrPDB Length = 326 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 48/313 (15%), Positives = 95/313 (30%), Gaps = 59/313 (18%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLW---NFGIKDKPTFIKGIGAGGSITGL 162 + TSL+ P+ + GS+ ++ W + G + + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 222 + N ++S + T RL + T ++ S+ + A+S +++ Sbjct: 73 VVSADG-NYAVSASWDKTLRLWNLATGNSEARFVGHTGDV--LSVAIDANSSKIISASRD 129 Query: 223 GNVILLNMDGKELWNLRMHKKKVTHVALNP---------CCDWFLATASVDQTVKIWDLR 273 + + N G + L H VT V + P +A +D+ V+ W L Sbjct: 130 KTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLN 189 Query: 274 QVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA---------SQWDCPL 324 + + + + H + +N SPDG+ + + +I V++ D Sbjct: 190 EDSYRIEADF-IGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVF 248 Query: 325 GLIPHPHRHF---------------------------------QHLTPIKAAWHPRYNLI 351 L P R + Q + AW + Sbjct: 249 ALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTL 308 Query: 352 VVGRYPDPNFKSC 364 G Y D + Sbjct: 309 FAG-YTDNVIRVW 320 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 64/192 (33%), Gaps = 12/192 (6%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK-ASFLYSL-PHRHPVNAA 294 L H VT ++ + L + S D+T+ W L + + + S H H V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 295 CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 354 S DG ++ +R+++ + + + H + A + I+ Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDV------LSVAIDANSSKIISA 126 Query: 355 RYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH 414 D + V G++ + P++ ++ + +++ M Sbjct: 127 SR-DKTIRVWNTVG-DCAYVLLGHTDWVTKVRVAPKNLEDGEVD--DGRITFVSAGMDKI 182 Query: 415 ILIWSQEEARTR 426 + WS E R Sbjct: 183 VRSWSLNEDSYR 194 >6EMK-B nrPDB Length = 303 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 46/269 (17%), Positives = 93/269 (34%), Gaps = 29/269 (10%) Query: 72 TLHQHKLGRASWPSVQ----QGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTV 127 T + L A +V+ + + + + + +R + F + + Sbjct: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ----------DNRWM 90 Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK 187 S+ G I +W+ P+ + + + +P N + + +G R+ D Sbjct: 91 VTSSEDGTIKVWDVR---SPSIPRNYKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLG 146 Query: 188 GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-------LWNLRM 240 N + + + SL +++ M+ + GN + M + R Sbjct: 147 ENQCTHQLTPED-DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 H +T + L+ LAT S D T ++W + + L H+ V FS D Sbjct: 206 HSTYITRILLSSDVK-HLATCSADHTARVWSIDDDFKLETTLD--GHQRWVWDCAFSADS 262 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 A L+T +R++ S + H Sbjct: 263 AYLVTASSDHYVRLWDLSTREIVRQYGGH 291 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 98/294 (33%), Gaps = 47/294 (15%) Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228 + ++ + T R + + + L+++ +++ T + NV L Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTI--QHSDSQVNRLEITNDKKLLATAGH-QNVRLY 58 Query: 229 NMDGKE---LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 ++ + + H+ VT V+ W + T+S D T+K+WD+R S + Sbjct: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRS----PSIPRNY 113 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK---- 341 H PVN P+ L++ D+ IR++ + C L P Q L+ Sbjct: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 Query: 342 ----------AAWHPRYNLIVVGRYPDPNFKSCTPYELR-----------------TIDV 374 W + P F++ + Y R T V Sbjct: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 Query: 375 FDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQEEARTRK 427 + + + D + F+ L +A H + +W + TR+ Sbjct: 234 WSIDDDFKLETTLDGHQRWVWDC-AFSADSAYLVTASSDHYVRLW---DLSTRE 283 Score = 62.2 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 52/160 (32%), Gaps = 9/160 (5%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK----GI 153 L + + P D + + S +A + G+ +W + +K Sbjct: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSAS 212 IT + + + S + T R+ L +W C SA Sbjct: 205 AHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC--AFSAD 261 Query: 213 SRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALN 251 S +VT + V L ++ +E + H K VALN Sbjct: 262 SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 >3C9C-A nrPDB Length = 432 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 47/310 (15%), Positives = 105/310 (33%), Gaps = 33/310 (10%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIK------DKPTF--IKGIGAGGSITG 161 + + P + +A + D++++++ ++ G G Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSAS-----SRM 215 L +NP ++S + T L D + I ++ + + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 216 VVTGDNVGNVILLNM----DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 + + +++ + K + H +V ++ NP ++ LAT S D+TV +WD Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSAS---QWDCPLGLI 327 LR ++ K S H+ + +SP L ++ + V+ S + Sbjct: 309 LRNLKLKLHSFES--HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 366 Query: 328 PHPHR----HFQHLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 P H H I +W+P I+ D + E +V++ ++ Sbjct: 367 DGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE----NVYNDEEPEI 422 Query: 383 MCQLYDPESS 392 + ++ Sbjct: 423 PASELETNTA 432 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 22/165 (13%), Positives = 45/165 (27%), Gaps = 30/165 (18%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFN 165 L+++P +A GS + LW+ K I ++++ Sbjct: 274 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDEIFQVQWS 332 Query: 166 PLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV 225 P N +S + + D Sbjct: 333 PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP---------------------- 370 Query: 226 ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270 + L+ H K++ + NP W + + S D +++W Sbjct: 371 -------ELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 >4BTS-AR nrPDB Length = 343 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 41/285 (14%), Positives = 99/285 (34%), Gaps = 35/285 (12%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSK---------GGDIMLWNFGIKDKPTFIKGIGA 155 ++ F +L H S +A+ + + LW+ ++ T+ + +G Sbjct: 60 EQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWD--LRTGTTYKRFVGH 117 Query: 156 GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA---- 211 + + F+P N Q ++ E +L + G A + + W + S Sbjct: 118 QSEVYSVAFSPDNR-QILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKS 176 Query: 212 ------SSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265 + + G + + N + + + + H+ V H++++P + +AT D+ Sbjct: 177 ANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKY-IATGGKDK 235 Query: 266 TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD---- 321 + IWD+ + +N F+P + + +++++ Sbjct: 236 KLLIWDILNLT---YPQREFDAGSTINQIAFNPKLQWVAVGTDQG-VKIFNLMTQSKAPV 291 Query: 322 CPLGLIPHPHRHFQHLTPIKA---AWHPRYNLIVVGRYPDPNFKS 363 C + P Q + AW+ + G + D ++ Sbjct: 292 CTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAG-FTDGVIRT 335 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 35/222 (15%), Positives = 76/222 (34%), Gaps = 30/222 (13%) Query: 210 SASSRMVVTGDNVGNVILLNMDGKELW--------NLRMHKKKVTHVALNPCCDWFLATA 261 + S ++++G V++ + +E L H V+ +AL+ + + ++ Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAI-SS 94 Query: 262 SVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 321 S D+T+++WDLR ++ + H+ V + FSPD ++L+ + EI++++ Sbjct: 95 SWDKTLRLWDLRTGT---TYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGEC 151 Query: 322 CPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYP-----DPNFKSCTPYELRTIDVFD 376 H + + Y D K + F Sbjct: 152 KFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTN-FQIRYTFK 210 Query: 377 GNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIW 418 + + P I++ +LIW Sbjct: 211 AHESNVNHLSISPNGKYIAT------------GGKDKKLLIW 240 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 40/281 (14%), Positives = 85/281 (30%), Gaps = 82/281 (29%) Query: 153 IGAGGSITGLK--FNPL---NTNQFYASSMEGTT-------------------------- 181 G +T + F+ ++ + S + T Sbjct: 18 EGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNH 77 Query: 182 -----------------------RLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 RL D + ++ S+ S +R +++ Sbjct: 78 FVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVY--SVAFSPDNRQILS 135 Query: 219 GDNVGNVILLNMDGKELWN---LRMHKKKVTHVALNPCCDW---------FLATASVDQT 266 + L N+ G+ ++ H V+ V +P + A+ D Sbjct: 136 AGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 +K+W+ + + +F H VN SP+G + T + ++ ++ Sbjct: 196 LKVWN-TNFQIRYTFK---AHESNVNHLSISPNGKYIATGGKDKKLLIWDILN------- 244 Query: 327 IPHPHRHFQHLTPI-KAAWHPRYNLIVVGRYPDPNFKSCTP 366 + +P R F + I + A++P+ + VG D K Sbjct: 245 LTYPQREFDAGSTINQIAFNPKLQWVAVG--TDQGVKIFNL 283 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 59/195 (30%), Gaps = 22/195 (11%) Query: 237 NLRMHKKKVTHV--ALNP---CCDWFLATASVDQTVKIWDLRQVRGKASFLYS----LPH 287 L H VT + + L + S D+TV IW L + F H Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 347 H V+ S + +++ +R++ + H + A+ P Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVY------SVAFSPD 129 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTIDVF--DGNSGKMMCQLYDPESSGISSLNEFNPMGD 405 I+ + K + +S + C Y P + S N+ P Sbjct: 130 NRQILSAG-AEREIKLWNILGECKFSSAEKENHSDWVSCVRYSP---IMKSANKVQPFAP 185 Query: 406 TLAS-AMGYHILIWS 419 AS + +W+ Sbjct: 186 YFASVGWDGRLKVWN 200 >5Y1U-A nrPDB Length = 456 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 53/311 (17%), Positives = 110/311 (35%), Gaps = 36/311 (11%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIK------DKPTF--IKGIGAGGSITG 161 + + P +P +A + D++++++ ++ G G Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKG-NILRVFASSDTINIWFCSLDVSAS-----SRM 215 L +NP + ++S + T L D + TI ++ S + Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 216 VVTGDNVGNVILLNM----DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 + + +++ + K ++ H +V ++ NP ++ LAT S D+TV +WD Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSAS---QWDCPLGLI 327 LR ++ K S H+ + +SP L ++ + V+ S + P Sbjct: 334 LRNLKLKLHSFES--HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 391 Query: 328 PHPHR----HFQHLTPIK-AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 P H H I +W+P ++ D + E ++++ + Sbjct: 392 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE----NIYNDEDPE- 446 Query: 383 MCQLYDPESSG 393 DPE G Sbjct: 447 --GSVDPEGQG 455 >3FM0-A nrPDB Length = 345 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 66/220 (30%), Gaps = 65/220 (29%) Query: 248 VALNPCCDWFLATASVDQ------------------------------------------ 265 +A NP LA+ D+ Sbjct: 22 LAWNPAGT-LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80 Query: 266 ---TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322 T IW Q + H + V + ++P G L T + + V+ + D Sbjct: 81 FDATTCIWKKNQDDFECVTTLE-GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139 Query: 323 PLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVF-DGNSGK 381 + + H Q + + WHP L+ Y D T+ ++ + Sbjct: 140 -YECVSVLNSHTQDVKHV--VWHPSQELLASASYDD------------TVKLYREEEDDW 184 Query: 382 MMCQLYDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQ 420 + C + S + SL F+P G LAS + IW Q Sbjct: 185 VCCATLEGHESTVWSL-AFDPSGQRLASCSDDRTVRIWRQ 223 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 85/279 (30%), Gaps = 37/279 (13%) Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKGN---ILRVFASSDTINIWFCSLDVSASSRMVVT 218 L +NP T + + R+ +G+ V + + S + + Sbjct: 22 LAWNPAGT-LLASCGGDRRIRIWGTEGDSWICKSVLSEGH--QRTVRKVAWSPCGNYLAS 78 Query: 219 GDNVGNVILLNM---DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 + D + + L H+ +V VA P + LAT S D++V +W++ + Sbjct: 79 ASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVDEE 137 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY--SASQWDCPLGLIPHPHRH 333 H V + P L + +++Y W C L H Sbjct: 138 DEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTV 197 Query: 334 FQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSG 393 + A+ P + D + Y GN + C DP Sbjct: 198 W------SLAFDPSGQRLASCS-DDRTVRIWRQY-------LPGNEQGVACSGSDPSWKC 243 Query: 394 ISSLNEFNP-----------MGDTLASAMGYHILIWSQE 421 I +L+ F+ G + I ++ ++ Sbjct: 244 ICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQED 282 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 48/285 (16%), Positives = 84/285 (29%), Gaps = 31/285 (10%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 R +AW P + +A S +W D G + + + P Sbjct: 60 HQRTVRKVAWSPC-GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG- 117 Query: 170 NQFYASSMEGTTRLQDFKGN---ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 N S + + + + +S T ++ + S ++ + V Sbjct: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKH--VVWHPSQELLASASYDDTVK 175 Query: 227 LLNM---DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL----------- 272 L D L H+ V +A +P LA+ S D+TV+IW Sbjct: 176 LYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNEQGVAC 234 Query: 273 --RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY----SASQWDCPLGL 326 K S H + + L T IRV+ ++ L Sbjct: 235 SGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSL 294 Query: 327 IPHPHR-HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELR 370 H H+ H Q + + AW+P+ ++ D Sbjct: 295 TAHLHQAHSQDVNCV--AWNPKEPGLLASCSDDGEVAFWKYQRPE 337 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 62/204 (30%), Gaps = 28/204 (13%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 D Y + + + WHP+ +A S + L+ D G + Sbjct: 138 DEYECVSVLNSHTQDVKHVVWHPSQ-ELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQD--FKGNILRVFASSDTINIWFCSLDVSASSRM- 215 + L F+P + S + T R+ GN V S W C +S Sbjct: 197 VWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNEQGVACSGSD-PSWKCICTLSGFHSRT 254 Query: 216 ------------VVTGDNVGNVILLNMDG---------KELWNL-RMHKKKVTHVALNPC 253 + T + + D +L + H + V VA NP Sbjct: 255 IYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK 314 Query: 254 CDWFLATASVDQTVKIWDLRQVRG 277 LA+ S D V W ++ G Sbjct: 315 EPGLLASCSDDGEVAFWKYQRPEG 338 >2YNP-A nrPDB Length = 604 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 103/305 (33%), Gaps = 21/305 (6%) Query: 113 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 172 R + +HPT P V G + LWN+ + + I+ + KF N Sbjct: 15 RVKGIDFHPTEP-WVLTTLYSGRVELWNYETQVEVRSIQVTE--TPVRAGKFIAR-KNWI 70 Query: 173 YASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG 232 S + R+ ++ V + + S+ V + V++G + V L N + Sbjct: 71 IVGSDDFRIRVFNYNTGEKVVDFEAHP--DYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN 128 Query: 233 K--ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 H+ V VA NP A+ +D+TVK+W L Q +F + Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS--TPNFTLTTGQERG 186 Query: 291 VNAACFS--PDGARLLTTDQKSEIRVYSASQWDCPLGLIPH-PHRHFQHLTPIKAAWHPR 347 VN + PD ++T I+++ C L H + F A +HP Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSF-------AVFHPT 239 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 407 +I+ G D K + + + C P + F+ L Sbjct: 240 LPIIISGS-EDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVL 298 Query: 408 ASAMG 412 + Sbjct: 299 SLGND 303 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 93/287 (32%), Gaps = 16/287 (5%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +++ + Q + +A++P PST A G + +W+ G + P F G Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLG-QSTPNFTLTTGQERG 186 Query: 159 ITGLKFNPL-NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + + + PL + +S + T ++ D++ N+ F + +++ Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV--FHPTLPIII 244 Query: 218 TGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 +G G + + N ++ L + ++ +A +P + D + L Sbjct: 245 SGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDE 304 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 S PV +S + + IR + D PL L Sbjct: 305 PTLSL-------DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTK-ELGSVD 356 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMM 383 + P A P + V D + T R F + Sbjct: 357 VFPQSLAHSPNGRFVTVVG--DGEYVIYTALAWRN-KAFGKCQDFVW 400 >5WJC-A nrPDB Length = 430 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 95/293 (32%), Gaps = 30/293 (10%) Query: 104 LQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPT------FIKGIGAGG 157 + + P D + P P +A +GG+ +++ D T G Sbjct: 124 ISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTA 183 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVF--------ASSDTINIWFCSLDV 209 GL +NP + + L D + A + Sbjct: 184 EGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQF 243 Query: 210 SASSR-MVVTGDNVGNVIL----LNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVD 264 ++ + + + + LN + + ++ H K + VA+NP D+ LATAS D Sbjct: 244 HPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASAD 303 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSASQ---- 319 +TV +WDLR + L H V +SP L ++ + ++ + Sbjct: 304 KTVALWDLRNPYQRLHTLE--GHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEE 361 Query: 320 ---WDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLIVVGRYPDPNFKSCTPYE 368 D G H H I +W P +V D + +P Sbjct: 362 QTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSR 414 Score = 78.4 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 34/230 (14%), Positives = 73/230 (31%), Gaps = 38/230 (16%) Query: 214 RMVVTGDNVGNVILLNMDGKELWN---------LRMHKKKVTHVALNPCCDWFLATASVD 264 ++ T GN + + + L+ H + + NP LAT + D Sbjct: 145 EIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAED 204 Query: 265 QTVKIWDLRQVRGKASFLYSLP-------HRHPVNAACFSP-DGARLLTTDQKSEIRVYS 316 Q + +WD++ +S + H VN F P A L + ++++ Sbjct: 205 QVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHD 264 Query: 317 A---SQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTP-YELRTI 372 + + P + H A +P + ++ D + + Sbjct: 265 TRLNPEEEAPKVIQAHSKAIN------AVAINPFNDYLLATASADKTVALWDLRNPYQRL 318 Query: 373 DVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEE 422 +G+ ++ + P I + +S+ + IW E+ Sbjct: 319 HTLEGHEDEVYGLEWSPHDEPILA-----------SSSTDRRVCIWDLEK 357 >3MKQ-A nrPDB Length = 814 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 103/305 (33%), Gaps = 21/305 (6%) Query: 113 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 172 R + +HPT P V G + +WN+ + + I+ + KF N Sbjct: 15 RVKGIDFHPTEP-WVLTTLYSGRVEIWNYETQVEVRSIQVTE--TPVRAGKFIAR-KNWI 70 Query: 173 YASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG 232 S + R+ ++ V + + S+ V + V++G + V L N + Sbjct: 71 IVGSDDFRIRVFNYNTGEKVVDFEAHP--DYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN 128 Query: 233 K--ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 H+ V VA NP A+ +D+TVK+W L Q +F + Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS--TPNFTLTTGQERG 186 Query: 291 VNAACFS--PDGARLLTTDQKSEIRVYSASQWDCPLGLIPH-PHRHFQHLTPIKAAWHPR 347 VN + PD ++T I+++ C L H + F A +HP Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSF-------AVFHPT 239 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 407 +I+ G D K + + + C P + F+ L Sbjct: 240 LPIIISGS-EDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVL 298 Query: 408 ASAMG 412 + Sbjct: 299 SLGND 303 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 93/287 (32%), Gaps = 16/287 (5%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 +++ + Q + +A++P PST A G + +W+ G + P F G Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLG-QSTPNFTLTTGQERG 186 Query: 159 ITGLKFNPL-NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + + + PL + +S + T ++ D++ N+ F + +++ Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV--FHPTLPIII 244 Query: 218 TGDNVGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 +G G + + N ++ L + ++ +A +P + D + L Sbjct: 245 SGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDE 304 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 S PV +S + + IR + D PL L Sbjct: 305 PTLSL-------DPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTK-ELGSVD 356 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMM 383 + P A P + V D + T R F + Sbjct: 357 VFPQSLAHSPNGRFVTVVG--DGEYVIYTALAWRN-KAFGKCQDFVW 400 >6QX9-5O nrPDB Length = 357 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 89/280 (31%), Gaps = 31/280 (11%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G G + KF+P + ++ + L + G+ L + Sbjct: 64 GHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLKGHSGA-VMELHYNTDG 121 Query: 214 RMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 M+ + V + + G+ + L+ H V + T S D TVK+WD+ Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 R+ +F + V A F+ ++++ ++I+V+ Q + H Sbjct: 182 RKKAAIQTFQNTYQ----VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD- 236 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYEL----RTIDVFDGNSGKMMCQLYD 388 + ++ D + R + +F GN L Sbjct: 237 ------SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290 Query: 389 PESSGISSLNEFNPMGDTLASAMGYH-ILIWSQEEARTRK 427 ++P G +A+ + +W + +R+ Sbjct: 291 CS---------WSPDGSKIAAGSADRFVYVW---DTTSRR 318 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 41/262 (15%), Positives = 94/262 (35%), Gaps = 21/262 (8%) Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 L ++ T S + S + +W+ + + G + Sbjct: 101 NYATLKGHSGAVMELHYN-TDGSMLFSASTDKTVAVWDS--ETGERVKRLKGHTSFVNSC 157 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNI-LRVFASSDTINIWFCSLDVSASSRMVVTGDN 221 S +GT +L D + ++ F ++ ++ + +S +++G Sbjct: 158 YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT----YQVLAVTFNDTSDQIISGGI 213 Query: 222 VGNVILLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 ++ + ++ +L + +R H VT ++L+ + L + ++D TV++WD+R K Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKER 272 Query: 281 FLYSLP---HRHPVNAA--CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQ 335 + H N +SPDG+++ + V+ + L H + Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE 332 Query: 336 HLTPIKAAWHPRYNLIVVGRYP 357 A+HP +I+ Sbjct: 333 ------VAFHPDEPIIISASSD 348 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 76/223 (34%), Gaps = 19/223 (8%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 ++ +++ S P V GS G + LW+ K I+ Sbjct: 139 ETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR---KKAAIQTFQNTYQ 195 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 + + FN ++Q + ++ ++ D + N L ++ SL S+ +++ Sbjct: 196 VLAVTFN-DTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSL--SSEGSYLLS 252 Query: 219 GDNVGNVILLNM-----DGKELWNLRM--HK--KKVTHVALNPCCDWFLATASVDQTVKI 269 V + ++ + + + H K + + +P +A S D+ V + Sbjct: 253 NAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYV 311 Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEI 312 WD R H +N F PD +++ + Sbjct: 312 WDTTSRRILYKLP---GHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 64/186 (34%), Gaps = 26/186 (13%) Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNA 293 + L H+ +V +P LA+A D+ + +W++ G +L H V Sbjct: 59 IMLLSGHEGEVYCCKFHPNGS-TLASAGFDRLILLWNV---YGDCDNYATLKGHSGAVME 114 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN-LIV 352 ++ DG+ L + + V+ + + L H + + + + R +V Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHT-------SFVNSCYPARRGPQLV 167 Query: 353 VGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMG 412 D K + I F N+ +++ ++ + ++ + Sbjct: 168 CTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFN------------DTSDQIISGGID 214 Query: 413 YHILIW 418 I +W Sbjct: 215 NDIKVW 220 >4V7E-Bg nrPDB Length = 380 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 47/306 (15%), Positives = 96/306 (31%), Gaps = 22/306 (7%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 + + SL W P + + S+ G +++WN K IK + F Sbjct: 60 RTLQGHSGKVYSLDWTPEK-NWIVSASQDGRLIVWNALTSQKTHAIKL--HCPWVMECAF 116 Query: 165 NPLNTNQFYASSMEGTTRLQDFK------GNILRVFASSDTINIWFCSLDVSASSRMVVT 218 P + ++ + + GN+ + V ++T Sbjct: 117 APNGQS-VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLIT 175 Query: 219 GDNVGNVILLNMD-GKELWNL-----RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 G +L ++ G+ + H V +++N + S D TV++WDL Sbjct: 176 GSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDL 235 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHR 332 R + H +N+ F PDG R T R++ P R Sbjct: 236 RITSRAVRTYH--GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDR 293 Query: 333 HFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTI----DVFDGNSGKMMCQLYD 388 + L + + ++ Y + + + + + + G++ C Sbjct: 294 NDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLS 353 Query: 389 PESSGI 394 + S + Sbjct: 354 SDGSAL 359 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 75/228 (32%), Gaps = 20/228 (8%) Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG-----IGAGG 157 + + A+S + P + + GS +LW+ + G Sbjct: 149 VSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWD--VTTGQRISIFGSEFPSGHTA 206 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 + L N LN N F + S + T RL D + V S+ + Sbjct: 207 DVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGD-INSVKFFPDGQRFG 265 Query: 218 TGDNVGNVILLNM-DGKELWNLRMHKKK-------VTHVALNPCCDWFLATASVDQTVKI 269 TG + G L +M G +L + VT VA + A + + Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFA-GYSNGDCYV 324 Query: 270 WD--LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 WD L ++ L + H ++ S DG+ L T ++++ Sbjct: 325 WDTLLAEMVLNLGTLQN-SHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 31/188 (16%), Positives = 61/188 (32%), Gaps = 15/188 (7%) Query: 234 ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD-LRQVRGKASFLYSLPHRHPVN 292 L+ H KV + P +W + +AS D + +W+ L + A L H V Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNW-IVSASQDGRLIVWNALTSQKTHAIKL----HCPWVM 112 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH-PRYNLI 351 F+P+G + S +++ S G +P H + + P Sbjct: 113 ECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETR 172 Query: 352 VVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAM 411 ++ D + I +F ++ + SL+ + + S Sbjct: 173 LITGSGDQTCVLWDVTTGQRISIFGSE-------FPSGHTADVLSLSINSLNANMFISGS 225 Query: 412 -GYHILIW 418 + +W Sbjct: 226 CDTTVRLW 233 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 49/175 (28%), Gaps = 53/175 (30%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 SL+ + + + GS + LW+ I + G G I +KF P Sbjct: 204 HTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVR-TYHGHEGDINSVKFFPDGQ 262 Query: 170 NQFYASSMEGTTRLQDFK-GNILRVFASS-----------------------------DT 199 F S +GT RL D + G+ L+V+ Sbjct: 263 R-FGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGD 321 Query: 200 INIW---------------------FCSLDVSASSRMVVTGDNVGNVILLNMDGK 233 +W L +S+ + TG N+ + G Sbjct: 322 CYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGH 376 Score = 29.8 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 28/64 (43%), Gaps = 3/64 (4%) Query: 357 PDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY-HI 415 D + + + + RT F+ + C+ S + SL+ + P + + SA + Sbjct: 33 LDTDVEKYSKAQGRTAVSFNPTD-LVCCRTLQGHSGKVYSLD-WTPEKNWIVSASQDGRL 90 Query: 416 LIWS 419 ++W+ Sbjct: 91 IVWN 94 >5Y88-O nrPDB Length = 451 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 47/329 (14%), Positives = 111/329 (33%), Gaps = 24/329 (7%) Query: 101 YRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSIT 160 +++ + +A P GS + +W+ + G ++ Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWD--LATGKLKTTLAGHVMTVR 186 Query: 161 GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGD 220 + + + ++ S + T + D + N + ++ + + ++ T Sbjct: 187 DVAVSDRHP-YLFSVSEDKTVKCWDLEKNQIIRDYYGH--LSGVRTVSIHPTLDLIATAG 243 Query: 221 NVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKA 279 + L +M + + L HK + V P D + ++S D TV++WD+ + Sbjct: 244 RDSVIKLWDMRTRIPVITLVGHKGPINQVQCTP-VDPQVVSSSTDATVRLWDVVAGKTMK 302 Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 + H+ V A P + + +IR + ++ T Sbjct: 303 VLTH---HKRSVRATALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEK-------TG 351 Query: 340 IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 399 I + ++ + + Y+ ++ + + + M + E S + S Sbjct: 352 IINTLSINQDDVLFAGGDNGVL---SFYDYKSGHKYQSLATREMVGSLEGERSVLCS--T 406 Query: 400 FNPMGDTLASAMGYH-ILIWSQEEARTRK 427 F+ G L + I IW Q+E T++ Sbjct: 407 FDKTGLRLITGEADKSIKIWKQDETATKE 435 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 49/294 (16%), Positives = 101/294 (34%), Gaps = 22/294 (7%) Query: 56 GLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLH--TLDSYRILQKAAPFDRR 113 LA ++ V T+ + P + + + L+ +I++ Sbjct: 168 DLATGKLKTTLAGHVMTVRDVAVSD-RHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSG 226 Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 173 +++ HPT +A + I LW+ + I +G G I ++ P++ Q Sbjct: 227 VRTVSIHPTL-DLIATAGRDSVIKLWDMR--TRIPVITLVGHKGPINQVQCTPVDP-QVV 282 Query: 174 ASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG 232 +SS + T RL D G ++V + + + V + +G Sbjct: 283 SSSTDATVRLWDVVAGKTMKVL--THHKRS-VRATALHPKEFSVASACTDDIRSWGLAEG 339 Query: 233 KELWNLRMHK-KKVTHVALNPCCDWFLATASVDQTVKIWDLR-----QVRGKASFLYSLP 286 L N K + +++N L + + +D + Q + SL Sbjct: 340 SLLTNFESEKTGIINTLSINQDD--VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLE 397 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVY---SASQWDCPLGLIPHPHRHFQHL 337 V + F G RL+T + I+++ + + GL +P+ + Sbjct: 398 GERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGLAWNPNLSAKRF 451 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 36/204 (17%), Positives = 68/204 (33%), Gaps = 30/204 (14%) Query: 228 LNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287 + K + H V VA++P + + T S D T+K+WDL + K + H Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTL---AGH 181 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI-KAAWHP 346 V S L + + ++ + + ++ HL+ + + HP Sbjct: 182 VMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIR-------DYYGHLSGVRTVSIHP 234 Query: 347 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG---KMMCQLYDPESSGISSLNEFNPM 403 +LI D K + G+ G ++ C DP Sbjct: 235 TLDLIATAGR-DSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDP-------------- 279 Query: 404 GDTLASAMGYHILIWSQEEARTRK 427 ++S+ + +W +T K Sbjct: 280 -QVVSSSTDATVRLWDVVAGKTMK 302 >3CFV-B nrPDB Length = 414 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 97/288 (33%), Gaps = 33/288 (11%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIK------DKPTF--IKGIGAGGSITG 161 + + P +P +A + D++++++ ++ G G Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSAS-----SRM 215 L +N + ++S + T L D G + I ++ + + Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 216 VVTGDNVGNVILLNMDGKELWN----LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 + + +++ + + H +V ++ NP ++ LAT S D+TV +WD Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 304 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSA----------SQW 320 LR ++ K S H+ + +SP L ++ + V+ Sbjct: 305 LRNLKLKLHTFES--HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 321 DCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYE 368 D P L+ H ++ W+P ++ D + E Sbjct: 363 DGPPELLFIHGGHTAKISDFS--WNPNEPWVICSVSEDNIMQIWQMAE 408 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 71/245 (28%), Gaps = 42/245 (17%) Query: 38 CAKGSGPSRRCD-SDCLWVGLAGPQ---------ILPPCRSIVRTLHQHKLGRASWPS-- 85 G S D + CLW AGP+ I ++V + H L + + S Sbjct: 190 NLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVA 249 Query: 86 VQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD 145 Q L + + + L+++P +A GS + LW+ Sbjct: 250 DDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL- 308 Query: 146 KPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC 205 K I + ++P N +S + + D A Sbjct: 309 KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPP-- 366 Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265 + L+ H K++ + NP W + + S D Sbjct: 367 ---------------------------ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 399 Query: 266 TVKIW 270 ++IW Sbjct: 400 IMQIW 404 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 35/108 (32%), Gaps = 21/108 (19%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNF----------GIK 144 LHT +S++ W P + + +A + +W+ + Sbjct: 312 LHTFESHKDEIFQVH---------WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 145 DKPTFIKGI--GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNI 190 D P + I G I+ +NP + S + ++ NI Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 >5Z56-q nrPDB Length = 504 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 52/333 (15%), Positives = 120/333 (36%), Gaps = 22/333 (6%) Query: 67 RSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPST 126 ++ V T + K G+ + + + S + S+ L A+ +L P+ + Sbjct: 179 KATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSAS--IPGILALDLCPSDTNK 236 Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 186 + G ++++++ + G +T + F+P + + +++S + T R+ Sbjct: 237 ILTGGADKNVVVFDKSSE--QILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV 293 Query: 187 KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKK-- 243 + L + A+ +++ + ++ G+ L + Sbjct: 294 PNASCVQVVRAH--ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 +T +P T ++D +KIWDL++ A+F H P+ + FS +G L Sbjct: 352 SLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERTNVANFP---GHSGPITSIAFSENGYYL 407 Query: 304 LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKS 363 T S ++++ + L + + L + + +G D Sbjct: 408 ATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSL-----IFDQSGTYLALGG-TDVQIYI 461 Query: 364 CTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 C + I F +SG + + I+S Sbjct: 462 CK--QWTEILHFTEHSGLTTGVAFGHHAKFIAS 492 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 85/257 (33%), Gaps = 44/257 (17%) Query: 100 SYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSI 159 S +IL ++ TS+ +HP+ V S I +W+ + + ++ Sbjct: 253 SEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRIWS--VPNASCVQVVRAHESAV 309 Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG 219 TGL + + +SS + D + + + +T + TG Sbjct: 310 TGLSLHATG-DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG 368 Query: 220 DNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 + + ++ + + N H +T +A + ++LATA+ D +VK+WDLR+++ Sbjct: 369 TMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKNF 427 Query: 279 ASF--------------------------------------LYSLPHRHPVNAACFSPDG 300 + L+ H F Sbjct: 428 KTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHA 487 Query: 301 ARLLTTDQKSEIRVYSA 317 + +T ++ YS Sbjct: 488 KFIASTGMDRSLKFYSL 504 >5NZU-C nrPDB Length = 905 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 7/192 (3%) Query: 96 HTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGA 155 +TL+ R+ A D +A HPT P + S I LW++ K G Sbjct: 87 NTLE--RVHMFEAHSD-YIRCIAVHPTQPF-ILTSSDDMLIKLWDWDKKWS-CSQVFEGH 141 Query: 156 GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRM 215 + + NP + NQF ++S++ T ++ + + Sbjct: 142 THYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPY 201 Query: 216 VVTGDNVGNVILLNMDGK-ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 274 +++G + V + + K + L H + V+ + +P + T S D TV+IW Sbjct: 202 LISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPEL-PIIITGSEDGTVRIWHSST 260 Query: 275 VRGKASFLYSLP 286 R +++ Y + Sbjct: 261 YRLESTLNYGME 272 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 100/289 (34%), Gaps = 22/289 (7%) Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 I +K R S+ HPT P +A G +WN + + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVC-VWNHETQT--LVKTFEVCDLPVRAA 63 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 222 KF N + + R+ ++ + RV + + V + ++T + Sbjct: 64 KFVAR-KNWVVTGADDMQIRVFNYNT-LERVHMFEAHSDY-IRCIAVHPTQPFILTSSDD 120 Query: 223 GNVILLNMDGK--ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 + L + D K H V + +NP + A+AS+D+T+K+W L G +S Sbjct: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL----GSSS 176 Query: 281 FLYSL-PHRHPVNAACFSPDGA--RLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 ++L H VN + G L++ ++++ C L H Sbjct: 177 PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVS--- 233 Query: 338 TPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386 A++HP +I+ G D + R + ++ C Sbjct: 234 ---CASFHPELPIIITGS-EDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Score = 94.5 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 95/275 (34%), Gaps = 26/275 (9%) Query: 156 GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRM 215 + + +P AS G+ + + + L + + ++ + A Sbjct: 15 SDRVKSVDLHPTEPWML-ASLYNGSVCVWNHETQTLVK--TFEVCDLPVRAAKFVARKNW 71 Query: 216 VVTGDNVGNVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 274 VVTG + + + N + + + H + +A++P + L T+S D +K+WD + Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFIL-TSSDDMLIKLWDWDK 130 Query: 275 VRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRH 333 + S ++ H H V +P D + + I+V+ L H Sbjct: 131 -KWSCSQVFE-GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE--- 185 Query: 334 FQHLTPIKAAWHPRYN---LIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 390 + + ++ G D K + +G++ + C + PE Sbjct: 186 ----KGVNCIDYYSGGDKPYLISGA-DDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE 240 Query: 391 ------SSGISSLNEFNPMGDTLASAMGYHI-LIW 418 S ++ ++ L S + Y + +W Sbjct: 241 LPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVW 275 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 67/187 (35%), Gaps = 27/187 (14%) Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRH-PVNAA 294 L +V V L+P W LA+ + +V +W+ + + + PV AA Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWN----HETQTLVKTFEVCDLPVRAA 63 Query: 295 CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 354 F ++T +IRV++ + + H A HP I+ Sbjct: 64 KFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYI------RCIAVHPTQPFILTS 117 Query: 355 RYPDPNFKSCT-PYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY 413 D K + VF+G++ +M + +P+ + N+F ASA Sbjct: 118 S-DDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDN-----NQF-------ASASLD 164 Query: 414 H-ILIWS 419 I +W Sbjct: 165 RTIKVWQ 171 >6Q8F-A nrPDB Length = 514 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 91/262 (34%), Gaps = 15/262 (5%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC-- 205 + G + +F+P S++G + +F +R + + Sbjct: 207 SRHIKFGQKSHVECARFSPDGQ-YLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 265 Query: 206 ----SLDVSASSRMVVTGDNVGNVILLNM-DGKELWNL-RMHKKKVTHVALNPCCDWFLA 259 + S + M+ TG G + + + G+ L R H K VT ++ + L Sbjct: 266 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL- 324 Query: 260 TASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 +AS DQT++I L+ + + H VN A F+ DG +++ +++++ Sbjct: 325 SASFDQTIRIHGLKSGK---TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKT 381 Query: 320 WDCPLGLIPHPHRHFQHLTPIKAAWHPR--YNLIVVGRYPDPNFKSCTPYELRTIDVFDG 377 +C +T P+ + +V R + +R+ Sbjct: 382 TECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 441 Query: 378 NSGKMMCQLYDPESSGISSLNE 399 G +C P I + E Sbjct: 442 EGGDFVCCALSPRGEWIYCVGE 463 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 47/328 (14%), Positives = 105/328 (32%), Gaps = 26/328 (7%) Query: 84 PSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGI 143 +V+ ++ F L + + + + P + GS G I +WNF Sbjct: 192 AAVKDVEEEKFPTQLSRHIKFGQKSH----VECARFSPD-GQYLVTGSVDGFIEVWNFTT 246 Query: 144 K------DKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFAS 196 + ++ + F+ +T + +G ++ + G LR F Sbjct: 247 GKIRKDLKYQAQDNFMMMDDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRFER 305 Query: 197 SDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCD 255 + + + L S S +++ + + + GK L R H V Sbjct: 306 AHSKGV--TCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGH 363 Query: 256 WFLATASVDQTVKIWDLRQVRGKASFL---YSLPHRHPVNAACFSP-DGARLLTTDQKSE 311 + + +AS D TVKIW+++ +F + VN+ P + + ++ + Sbjct: 364 YII-SASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNT 422 Query: 312 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 371 + + + + A PR I D + + Sbjct: 423 VVIMNMQ-GQIVRSFSSGKREGGD---FVCCALSPRGEWIYCVG-EDFVLYCFSTVTGKL 477 Query: 372 IDVFDGNSGKMMCQLYDPESSGISSLNE 399 + ++ + P + I++ +E Sbjct: 478 ERTLTVHEKDVIGIAHHPHQNLIATYSE 505 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 35/252 (13%), Positives = 82/252 (32%), Gaps = 21/252 (8%) Query: 72 TLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGS 131 + L + + + L + + T L++ S + S Sbjct: 274 SRDTEMLATGAQDGKIKVWKIQSGQCLR-----RFERAHSKGVTCLSFSKDS-SQILSAS 327 Query: 132 KGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKG--- 188 I + G+K T + G + F ++S +GT ++ + K Sbjct: 328 FDQTIRI--HGLKSGKTLKEFRGHSSFVNEATFTQDGH-YIISASSDGTVKIWNMKTTEC 384 Query: 189 -NILRVFASSDTINIWFCSLDVSASSR-MVVTGDNVGNVILLNMDGKELWNLRMHKKK-- 244 N + S+ +I S+ + + V + V+++NM G+ + + K++ Sbjct: 385 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGG 444 Query: 245 -VTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 AL+P +W D + + + + + H V P + Sbjct: 445 DFVCCALSPRGEWIYCVG-EDFVLYCFSTVTGKLERTLTV---HEKDVIGIAHHPHQNLI 500 Query: 304 LTTDQKSEIRVY 315 T + ++++ Sbjct: 501 ATYSEDGLLKLW 512 >4LG8-A nrPDB Length = 354 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 102/286 (35%), Gaps = 20/286 (6%) Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 173 +L P+ + + G ++++++ + G +T + F+P + + + Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSE--QILATLKGHTKKVTSVVFHP-SQDLVF 130 Query: 174 ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DG 232 ++S + T R+ + L + A+ +++ + ++ G Sbjct: 131 SASPDATIRIWSVPNASCVQVVRAH--ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTG 188 Query: 233 KELWNLRMHKK--KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 + L + +T +P T ++D +KIWDL++ A+F H P Sbjct: 189 RVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERTNVANFP---GHSGP 244 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNL 350 + + FS +G L T S ++++ + L + + L + Sbjct: 245 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSL-----IFDQSGTY 299 Query: 351 IVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 + +G D C + I F +SG + + I+S Sbjct: 300 LALGG-TDVQIYICK--QWTEILHFTEHSGLTTGVAFGHHAKFIAS 342 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 85/257 (33%), Gaps = 44/257 (17%) Query: 100 SYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSI 159 S +IL ++ TS+ +HP+ V S I +W+ + + ++ Sbjct: 103 SEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRIWS--VPNASCVQVVRAHESAV 159 Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG 219 TGL + + +SS + D + + + +T + TG Sbjct: 160 TGLSLHATG-DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG 218 Query: 220 DNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 + + ++ + + N H +T +A + ++LATA+ D +VK+WDLR+++ Sbjct: 219 TMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKNF 277 Query: 279 ASF--------------------------------------LYSLPHRHPVNAACFSPDG 300 + L+ H F Sbjct: 278 KTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHA 337 Query: 301 ARLLTTDQKSEIRVYSA 317 + +T ++ YS Sbjct: 338 KFIASTGMDRSLKFYSL 354 >4XYI-A nrPDB Length = 430 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 48/291 (16%), Positives = 100/291 (34%), Gaps = 30/291 (10%) Query: 104 LQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGI-KDKPTFIKG-----IGAGG 157 + + + + P +P +A G+ +++ + +++P G Sbjct: 124 IVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTS 183 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL--RVFASSDTINIWFCSLDVSASSR- 214 GL +N + + + + + D KG L ++++ V + Sbjct: 184 EGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQF 243 Query: 215 ------MVVTGDNVGNVILLNM----DGKELWNLRMHKKKVTHVALNPCCDWFLATASVD 264 ++ + + + + + ++ H++ V VA NP D+ LATAS D Sbjct: 244 HLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASAD 303 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSA----SQ 319 TV +WDLR++ + L H V +SP L+T+ + V+ + Sbjct: 304 HTVALWDLRRLNQRLHTLE--GHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEE 361 Query: 320 WDCPLGLIPHPHRHFQHLTPIKAA----WHPRYNLIVVGRYPDPNFKSCTP 366 P F H W+P ++ D + +P Sbjct: 362 QTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSP 412 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 52/313 (16%), Positives = 96/313 (30%), Gaps = 39/313 (12%) Query: 135 DIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVF 194 + NF ++ I G + +F P N + + G + D + Sbjct: 110 KMKPANFKGDYGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPI 169 Query: 195 ASSDTINIWFCSLDVSASSRM-----------VVTGDNVGNVILLNMDGKELWNLRM--- 240 + L S + TG ++ + ++ GK L + Sbjct: 170 VQTGH----QACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDV 225 Query: 241 --------HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVN 292 H V + + + L + S D T++I D R ++ H PVN Sbjct: 226 APVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVN 285 Query: 293 AACFSP-DGARLLTTDQKSEIRVYSASQ-WDCPLGLIPHPHRHFQHLTPIKAAWHPRYNL 350 F+P + L T + ++ + L H + W P Sbjct: 286 GVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVY------NVQWSPHDEP 339 Query: 351 IVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLY--DPESSGISSLNEFNPMGD-TL 407 I+V D ++ + + ++ ++ +S L +NP L Sbjct: 340 ILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDL-SWNPNNKWVL 398 Query: 408 ASAMGYHIL-IWS 419 AS +IL IWS Sbjct: 399 ASLADDNILQIWS 411 >5WYK-BB nrPDB Length = 943 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 64/344 (18%), Positives = 114/344 (33%), Gaps = 52/344 (15%) Query: 97 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG 156 L ++ I + D R+ + +A S G + +WN IK Sbjct: 379 PLKTHTIELQGQRTDVRSIDI---SDDNKLLATASN-GSLKIWN--IKTHKCIRTFE--C 430 Query: 157 GSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR-VFASSDTINIWFCSLDVSASSRM 215 G KF P + G +L D + L + IW SLD+++ + Sbjct: 431 GYALTCKFLPGGL-LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIW--SLDLTSDGKR 487 Query: 216 VVTGDNVGNVILLN----------MDGKELWNLRMH-------KKKVTHVALNPCCDWFL 258 +VTG V + K L L++H + V ++P + L Sbjct: 488 LVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRY-L 546 Query: 259 ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318 A + +D TVK++ L ++ +L H+ PV + S D ++T+ I+++ Sbjct: 547 AISLLDNTVKVFFLDSMKF---YLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLD 603 Query: 319 QWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGN 378 DC L F H I + D K + I + Sbjct: 604 FGDCHKSL-------FAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAH 656 Query: 379 SGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEE 422 ++ + G ++S+ + I IW + E Sbjct: 657 QSEVWALAVATDG------------GFVVSSSHDHSIRIWEETE 688 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 82/230 (35%), Gaps = 23/230 (10%) Query: 108 APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDK---PTFIKGI----------- 153 D SL + GS + W+F +++ T K + Sbjct: 470 DAHDAAIWSLDLTSD-GKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTL 528 Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 I ++ +P + S ++ T ++ + + + S+D+S S Sbjct: 529 ELTDDILCVRVSPDDR-YLAISLLDNTVKVFFLDSMKFYLSLYGHKLPV--LSIDISFDS 585 Query: 214 RMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 +M++T N+ + +D G +L H+ + +V P F + S D VK WD Sbjct: 586 KMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFF-SCSKDAVVKYWDG 644 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322 + H+ V A + DG ++++ IR++ ++ Sbjct: 645 EKFECIQKL---YAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 36/168 (21%), Positives = 59/168 (35%), Gaps = 17/168 (10%) Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 T L H +AVG G I +W+ + K + G +IT L+F+ T + Sbjct: 83 TYLEAH-KDTDLLAVGYADGVIKVWD--LMSKTVLLNFNGHKAAITLLQFDGTGTR-LIS 138 Query: 175 SSMEGTTRLQDFKGNILRVFASSD---TINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231 S + + D G + S W D +++ G + L ++ Sbjct: 139 GSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGED------WLISTSKDGMIKLWDLK 192 Query: 232 -GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 + + H + +A+ D L T D VKIW L K Sbjct: 193 THQCIETHIAHTGECWGLAVK---DDLLITTGTDSQVKIWKLDIENDK 237 Score = 68.7 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 66/250 (26%), Gaps = 58/250 (23%) Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 Q S++E + D K L VS S + G + Sbjct: 39 GQLITSALED-VNIWDIKTGDL-----------------VSKLSDGLPPGASDAR----G 76 Query: 230 MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRH 289 E L HK LA D +K+WDL K L H+ Sbjct: 77 AKPAECTYLEAHKDT-----------DLLAVGYADGVIKVWDLMS---KTVLLNFNGHKA 122 Query: 290 PVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 + F G RL++ + S I V+ L H I W + Sbjct: 123 AITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKD-------SITGFWCQGED 175 Query: 350 LIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLAS 409 ++ D K + I+ ++G+ + + + Sbjct: 176 WLISTS-KDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDL--------------LITT 220 Query: 410 AMGYHILIWS 419 + IW Sbjct: 221 GTDSQVKIWK 230 >5CXC-A nrPDB Length = 510 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 37/190 (19%), Positives = 70/190 (36%), Gaps = 11/190 (5%) Query: 155 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASS 213 T F+P + Y++S + T R D G ++ + + +S Sbjct: 311 HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTS 370 Query: 214 RMVVTGDNVGNVILLNMDGKE----LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 ++ G + ++ +++ + LR H KV ++ +P ++ L + S D T ++ Sbjct: 371 PLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRV 430 Query: 270 WDLRQVRGKASFLYSL-PHRHPVNAA---CFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 WDLR VR SL PV ++ G + +V+S WD Sbjct: 431 WDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDG-CKVFSV-VWDKLGI 488 Query: 326 LIPHPHRHFQ 335 + Q Sbjct: 489 FSGGEDKKVQ 498 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 73/277 (26%), Gaps = 88/277 (31%) Query: 126 TVAVGSKGGDIMLWNFG---IKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTR 182 V S G + +WN I P+ G G SI KF + ++ M+ T R Sbjct: 160 RVLSASYDGLLRIWNASGSVIATSPSGSHG-GHTASIKAAKFLTSDR--LASAGMDRTVR 216 Query: 183 LQ----------------------------DFKGNILRVFASSDT--INIWFCSLDVS-- 210 + D G+ + +S I W S + Sbjct: 217 VWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPE 276 Query: 211 ASSRMV----VTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQT 266 + ++ V+ + L +H T +P +AS D T Sbjct: 277 PDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHT 336 Query: 267 VKIWDLRQVRGKASFLYSLP---------------------------------------- 286 V+ DL + ++ + P Sbjct: 337 VRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSV 396 Query: 287 -----HRHPVNAACFSPDGAR-LLTTDQKSEIRVYSA 317 H + V + SP+ L++ RV+ Sbjct: 397 MTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDL 433 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 64/221 (28%), Gaps = 39/221 (17%) Query: 193 VFASSDTINIWFCSLD----VSASSRMVVTGDNVGNVILLNMDGKELWNLR-----MHKK 243 V +++ W + + V V++ G + + N G + H Sbjct: 134 VLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTA 193 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS----LPHRHPVNAACFSPD 299 + LA+A +D+TV++W + L H V+ Sbjct: 194 SIKAAKFL--TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGH 251 Query: 300 GARLLTTDQKSEIRVYSASQWDCPL---GLIPHPHRHFQ--------------------H 336 +LT I +SAS+ P L+P H + H Sbjct: 252 SKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIH 311 Query: 337 LTPIKAA-WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFD 376 P AA + PR + D ++ + + Sbjct: 312 TAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLT 352 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 30/235 (12%), Positives = 66/235 (28%), Gaps = 30/235 (12%) Query: 40 KGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLD 99 + S + +GL P +I + AS + L + + Sbjct: 290 RRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVS 349 Query: 100 SYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKP-TFIKGIGAGGS 158 + + + P +A G+ I + + + + G Sbjct: 350 TLTLTHPLLSLSALTRAGTTSPL----LAAGTSARHITMVDPRASSATTSVMTLRGHANK 405 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 + L +P N + S +GT R+ D + S+ + + Sbjct: 406 VVSLSPSPENEYSLVSGSHDGTCRVWDLR------------------SVRPATKEEGSLG 447 Query: 219 GDNVGNVIL----LNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 G + ++ GK+ + KV V + + D+ V++ Sbjct: 448 GVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVW---DKLGIFSGGEDKKVQV 499 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 39/108 (36%), Gaps = 15/108 (13%) Query: 298 PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH-RHFQHLTPIKAAWHPRYNLIVVGRY 356 P R+L+ +R+++AS + P H H IKAA + + Sbjct: 156 PGQERVLSASYDGLLRIWNASG----SVIATSPSGSHGGHTASIKAAKFLTSDRLASAG- 210 Query: 357 PDPNFKSCTPYE--------LRTIDVFDGNSGKMMCQLYDPESSGISS 396 D + E T++++ G++G + D S I + Sbjct: 211 MDRTVRVWKYTESDHFTGELKPTLELY-GHTGSVDWLDVDGHSKHILT 257 >6ID0-T nrPDB Length = 514 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 47/333 (14%), Positives = 106/333 (31%), Gaps = 34/333 (10%) Query: 101 YRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSIT 160 +++ + + +A P GS I +W+ + + G ++ Sbjct: 194 WKLYRVISGHLGWVRCIAVEPG-NQWFVTGSADRTIKIWD--LASGKLKLSLTGHISTVR 250 Query: 161 GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGD 220 G+ + + ++ + + D + N + LD+ + ++VT Sbjct: 251 GVIVSTRSP-YLFSCGEDKQVKCWDLEYNKVIRHYHGH--LSAVYGLDLHPTIDVLVTCS 307 Query: 221 NVGNVILLNMDGK-ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKA 279 + ++ K + L H V V + + T S D T+++WDL + + Sbjct: 308 RDSTARIWDVRTKASVHTLSGHTNAVATVR-CQAAEPQIITGSHDTTIRLWDLVAGKTRV 366 Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 + H+ V A P + + I+ + L H Sbjct: 367 TLTN---HKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGH--------NA 414 Query: 340 IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP----ESSGIS 395 I + ++V + + RT G + + + P SGI Sbjct: 415 IINTLTVNSDGVLVSGADNGTMHLW---DWRT-----GYNFQRVHAAVQPGSLDSESGIF 466 Query: 396 SLNEFNPMGDTLASAMGYH-ILIWSQEEARTRK 427 + F+ L +A I ++ +++ T + Sbjct: 467 AC-AFDQSESRLLTAEADKTIKVYREDDTATEE 498 Score = 103 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 80/227 (35%), Gaps = 13/227 (5%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 L+ ++++ L HPT + S+ +W+ ++ K + G Sbjct: 275 LEYNKVIRHYHGHLSAVYGLDLHPT-IDVLVTCSRDSTARIWD--VRTKASVHTLSGHTN 331 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 ++ ++ Q S + T RL D RV ++ ++ ++ + Sbjct: 332 AVATVR-CQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSV--RAVVLHPRHYTFA 388 Query: 218 TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR---- 273 +G DG + NL H + + +N L + + + T+ +WD R Sbjct: 389 SGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYN 446 Query: 274 -QVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 Q A SL + A F +RLLT + I+VY Sbjct: 447 FQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDD 493 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 66/202 (32%), Gaps = 29/202 (14%) Query: 228 LNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287 + K + H V +A+ P WF T S D+T+KIWDL + K S H Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWF-VTGSADRTIKIWDLASGKLKLSLT---GH 245 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 347 V S L + + +++ + H H H + + HP Sbjct: 246 ISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIR----HYHGHLSAVYGLDL--HPT 299 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG---KMMCQLYDPESSGISSLNEFNPMG 404 +++V D + ++ G++ + CQ +P Sbjct: 300 IDVLVTCSR-DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEP--------------- 343 Query: 405 DTLASAMGYHILIWSQEEARTR 426 + + I +W +TR Sbjct: 344 QIITGSHDTTIRLWDLVAGKTR 365 >5UZ7-B nrPDB Length = 351 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 101/304 (33%), Gaps = 19/304 (6%) Query: 102 RILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITG 161 R + + ++ W T + S+ G +++W+ +K I + Sbjct: 57 RTRRTLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR--SSWVMT 113 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKGN--ILRVFASSDTINIWFCSLDVSASSRMVVTG 219 + P N ++ + + K +RV + ++ +VT Sbjct: 114 CAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTS 171 Query: 220 DNVGNVILLNMDGKELWNLRM-HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 L +++ + H V ++L P + + D + K+WD+R+ + Sbjct: 172 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLWDVREGMCR 230 Query: 279 ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 +F H +NA CF P+G T + R++ + + H + Sbjct: 231 QTFT---GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM-----TYSHDNIIC 282 Query: 339 PIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLY--DPESSGISS 396 I + + +++ Y D N + V G+ ++ C D + S Sbjct: 283 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGS 342 Query: 397 LNEF 400 + F Sbjct: 343 WDSF 346 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 76/233 (32%), Gaps = 20/233 (8%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTH--------PSTVAVGSKGGDIMLWNFGIKDK 146 L + S L+ R + LA H + + + S LW+ I+ Sbjct: 128 LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD--IETG 185 Query: 147 PTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCS 206 G G + L P +T F + + + + +L D + + R + +I Sbjct: 186 QQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAIC 244 Query: 207 LDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKK---KVTHVALNPCCDWFLATASV 263 + TG + L ++ + H +T V+ + LA Sbjct: 245 --FFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLA-GYD 301 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 D +WD + H + V+ + DG + T S +++++ Sbjct: 302 DFNCNVWDALKADRAGVL---AGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 80/221 (36%), Gaps = 15/221 (6%) Query: 52 CLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFD 111 + LAG S R L +++ +S L +++ + Sbjct: 145 RVSRELAGH---TGYLSCCRFLDDNQIVTSS--GDTTC----ALWDIETGQQTTTFTGHT 195 Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 SL+ P G+ LW+ +++ G I + F P N N Sbjct: 196 GDVMSLSLAPDT-RLFVSGACDASAKLWD--VREGMCRQTFTGHESDINAICFFP-NGNA 251 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN-M 230 F S + T RL D + + + S D I S+ S S R+++ G + N + + + Sbjct: 252 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 311 Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 L H +V+ + + +AT S D +KIW+ Sbjct: 312 KADRAGVLAGHDNRVSCLGVT-DDGMAVATGSWDSFLKIWN 351 >6QDV-o nrPDB Length = 513 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 43/320 (13%), Positives = 106/320 (33%), Gaps = 25/320 (7%) Query: 84 PSVQQGLQQSFLHTLDSYRILQKA---APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWN 140 P +S + Y ++ + + +++ P + S I LW Sbjct: 192 PQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE 251 Query: 141 FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTI 200 + + IG ++ + FN T QF +++ + +L D + ++ + Sbjct: 252 VYGERR-CLRTFIGHSKAVRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKV 309 Query: 201 NIWFCSLDVSAS---SRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDW 256 + + + V G + ++ ++ G+ + H V + Sbjct: 310 PY---CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRR 366 Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 F++T S D+++++W+ H P A SP+G L ++I ++ Sbjct: 367 FVST-SDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFG 423 Query: 317 ASQWDCPLGLIPHPHRHFQ-HLTPIKAA---WHPRYNLIVVGRYPDPNFKSCTPYELRTI 372 A + + F+ H+ A + P + ++ G + + Sbjct: 424 AQN-----RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGD-GNGKLNIWDWKTTKLY 477 Query: 373 DVFDGNSGKMMCQLYDPESS 392 F + + ++ P + Sbjct: 478 SRFKAHDKVCIGAVWHPHET 497 Score = 84.9 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 24/209 (11%), Positives = 73/209 (34%), Gaps = 17/209 (8%) Query: 117 LAWHPTHPST--VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 + ++P G I+ W+ I+ + G++ + F N F + Sbjct: 313 VKFNPDEDKQNLFVAGMSDKKIVQWD--IRSGEIVQEYDRHLGAVNTIVFVDENRR-FVS 369 Query: 175 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK- 233 +S + + R+ ++ + + ++ ++ +S + + + +++ + Sbjct: 370 TSDDKSLRVWEWDIPVDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRF 428 Query: 234 ---ELWNLRMH--KKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHR 288 + + H V +P + + + + + IWD + + + F H Sbjct: 429 RLNKKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTTKLYSRFK---AHD 484 Query: 289 HPVNAACFSPDGA-RLLTTDQKSEIRVYS 316 A + P +++T I+++ Sbjct: 485 KVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 78.4 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 62/178 (34%), Gaps = 7/178 (3%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + S I+Q+ ++ + S + +W + I +I + Sbjct: 339 IRSGEIVQEYDRHLGAVNTIVF-VDENRRFVSTSDDKSLRVWEWDIPVDFKYIA-EPSMH 396 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGN---ILRVFASSDTINIWFCSLDVSASSR 214 S+ + +P N SM+ + + + + + C +D S Sbjct: 397 SMPAVTLSP-NGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMS 455 Query: 215 MVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 V++GD G + + + +L++ + H K +P + T D +K+WD Sbjct: 456 YVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 43/320 (13%), Positives = 106/320 (33%), Gaps = 25/320 (7%) Query: 84 PSVQQGLQQSFLHTLDSYRILQKA---APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWN 140 P +S + Y ++ + + +++ P + S I LW Sbjct: 258 PQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE 317 Query: 141 FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTI 200 + + IG ++ + FN T QF +++ + +L D + ++ + Sbjct: 318 VYGERR-CLRTFIGHSKAVRDICFNTAGT-QFLSAAYDRYLKLWDTETGQCISRFTNRKV 375 Query: 201 NIWFCSLDVSAS---SRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDW 256 + + + V G + ++ ++ G+ + H V + Sbjct: 376 PY---CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRR 432 Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 F++T S D+++++W+ H P A SP+G L ++I ++ Sbjct: 433 FVST-SDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFG 489 Query: 317 ASQWDCPLGLIPHPHRHFQ-HLTPIKAA---WHPRYNLIVVGRYPDPNFKSCTPYELRTI 372 A + + F+ H+ A + P + ++ G + + Sbjct: 490 AQN-----RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGD-GNGKLNIWDWKTTKLY 543 Query: 373 DVFDGNSGKMMCQLYDPESS 392 F + + ++ P + Sbjct: 544 SRFKAHDKVCIGAVWHPHET 563 Score = 84.5 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 24/209 (11%), Positives = 73/209 (34%), Gaps = 17/209 (8%) Query: 117 LAWHPTHPST--VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 + ++P G I+ W+ I+ + G++ + F N F + Sbjct: 379 VKFNPDEDKQNLFVAGMSDKKIVQWD--IRSGEIVQEYDRHLGAVNTIVFVDENRR-FVS 435 Query: 175 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK- 233 +S + + R+ ++ + + ++ ++ +S + + + +++ + Sbjct: 436 TSDDKSLRVWEWDIPVDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRF 494 Query: 234 ---ELWNLRMH--KKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHR 288 + + H V +P + + + + + IWD + + + F H Sbjct: 495 RLNKKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTTKLYSRFK---AHD 550 Query: 289 HPVNAACFSPDGA-RLLTTDQKSEIRVYS 316 A + P +++T I+++ Sbjct: 551 KVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 62/178 (34%), Gaps = 7/178 (3%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + S I+Q+ ++ + S + +W + I +I + Sbjct: 405 IRSGEIVQEYDRHLGAVNTIVF-VDENRRFVSTSDDKSLRVWEWDIPVDFKYIA-EPSMH 462 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGN---ILRVFASSDTINIWFCSLDVSASSR 214 S+ + +P N SM+ + + + + + C +D S Sbjct: 463 SMPAVTLSP-NGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMS 521 Query: 215 MVVTGDNVGNVILLNMDGKELWN-LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 V++GD G + + + +L++ + H K +P + T D +K+WD Sbjct: 522 YVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 >4L9O-A nrPDB Length = 349 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 37/261 (14%), Positives = 80/261 (30%), Gaps = 20/261 (7%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + +A S I ++ +++ IG G + + + +P + S +G Sbjct: 80 YGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKV 139 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNM-DGKELW-- 236 + + A S+ + +++ + G + ++ DG L Sbjct: 140 LIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPI 199 Query: 237 NLRMHKKKVTHVALN----PCCDWFLATASVDQTVKIWDLRQVRGKASFLYS---LPHRH 289 ++ H V + P + D VKIW R +F+ H Sbjct: 200 VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIW--RYDDAAKTFIEEEAFQGHSD 257 Query: 290 PVNAACFSPDG---ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHP 346 V +SP + + T Q + +++ P F + +A+W Sbjct: 258 WVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVC-WRASWSL 316 Query: 347 RYNLIVVGRYPDPNFKSCTPY 367 N++ + D Sbjct: 317 SGNVLAISG-GDNKVTLWKEN 336 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 87/233 (37%), Gaps = 16/233 (6%) Query: 99 DSYRILQKAAPFDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 ++ R+++ + +AW HP +A S G +++W + Sbjct: 101 ENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQA 160 Query: 158 SITGLKFNPLNTN-QFYASSMEGTTRLQDFK--GNILRVFASSDTINIWFCS---LDVSA 211 S+ + + P +S +G + +FK G + + I + S + + Sbjct: 161 SVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPD 220 Query: 212 SSRMVVTGDNVGNVILLNMDGK-----ELWNLRMHKKKVTHVALNPC--CDWFLATASVD 264 ++R V+G V + D E + H V VA +P ++ATAS D Sbjct: 221 NTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQD 280 Query: 265 QTVKIW--DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 +TV IW D + + + L A +S G L + +++ ++ Sbjct: 281 RTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 33/113 (29%), Gaps = 11/113 (9%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVY--SASQWDCPLGLIPHPHRHFQHLTPIKAA 343 H ++ A G RL T I+++ LI H +Q A Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQ------VA 120 Query: 344 W-HPRYNLIVVGRYPDPNFKSCTPYE--LRTIDVFDGNSGKMMCQLYDPESSG 393 W HP++ +I+ D + + + + P G Sbjct: 121 WAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYG 173 >6N9G-C nrPDB Length = 353 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 44/259 (16%), Positives = 78/259 (30%), Gaps = 22/259 (8%) Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG----AGGSITGLKFNPLNT 169 + A+ P +A G ++ ++ F + Sbjct: 108 VMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166 Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 Q +S +GT L D + L ++ L S + V+G ++ + Sbjct: 167 -QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWD 225 Query: 230 M-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHR 288 M G+ + H+ V V P D F A+ S D T +++DLR R + Sbjct: 226 MRSGQCVQAFETHESDVNSVRYYPSGDAF-ASGSDDATCRLYDLRADR----EVAIYSKE 280 Query: 289 HPV---NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 345 + ++ FS G L I V+ + L H +R Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS------TLRVS 334 Query: 346 PRYNLIVVGRYPDPNFKSC 364 P G + D + Sbjct: 335 PDGTAFCSGSW-DHTLRVW 352 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 39/322 (12%), Positives = 90/322 (27%), Gaps = 34/322 (10%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 + + + W + S+ G +++W+ +K + + + Sbjct: 57 RTLKGHGNKVLCMDWC-KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTM--PCTWVMACAY 113 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFAS-----SDTINIWFCSLDVSASSRMVVTG 219 P ++ + + A+ + N + S ++T Sbjct: 114 APSGCA-IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSAC-SFTNSDMQILTA 171 Query: 220 DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNP-CCDWFLATASVDQTVKIWDLRQVRG 277 G L ++ G+ L + H V + L P + D+ +WD+R G Sbjct: 172 SGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS--G 229 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 + + H VN+ + P G + + R+Y + Sbjct: 230 QCVQAFET-HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESI-----I 283 Query: 338 TPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSL 397 + ++ Y D + + + G+ ++ S Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRV-------------ST 330 Query: 398 NEFNPMGDTLASAMGYH-ILIW 418 +P G S H + +W Sbjct: 331 LRVSPDGTAFCSGSWDHTLRVW 352 >3JB9-L nrPDB Length = 340 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 64/370 (17%), Positives = 122/370 (32%), Gaps = 44/370 (11%) Query: 1 MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGP 60 M +K E+ +V R R + S L +GS R D + + + G Sbjct: 1 MDKRKESESATNGHLVKRIRIQDS-----------SLITEGSVLQRTSDLNVPNLQMFGH 49 Query: 61 QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWH 120 +V AS +Q L + + +Y +L T L W Sbjct: 50 TAEV----LVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGC---KGAITDLQWS 102 Query: 121 PTHPSTVAVGSK-GGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEG 179 S V S +M W+ K G G + L + + + S + Sbjct: 103 RD--SRVVYCSSSDTHLMSWDAV--SGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDC 158 Query: 180 TTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWNL 238 T ++ D + ++ ++ V G G + + ++ L Sbjct: 159 TMKVWDSRSKDCIKTIEEK---YPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVL 215 Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL-------RQVRGKASFLYSLPHRHPV 291 + HK +T +A++ L + S+D TV+I+D+ RQ++ ++ H + Sbjct: 216 KGHKDIITSLAISKDGSSLL-SNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHN--L 272 Query: 292 NAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI 351 +S + + + V+SA D L H + + +HP ++I Sbjct: 273 LGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRYVLPGHEG----SVNHVD--FHPHQDII 325 Query: 352 VVGRYPDPNF 361 + F Sbjct: 326 LSCSSDRTIF 335 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 58/329 (17%), Positives = 104/329 (31%), Gaps = 22/329 (6%) Query: 70 VRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAV 129 +R + S L L + + A FD S A Sbjct: 19 IRIQDSSLITEGSVLQRTSDLNVPNLQ-MFGHTAEVLVARFD----------PSGSYFAS 67 Query: 130 GSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGN 189 G I+LWN D + G G+IT L+++ ++ Y SS + D Sbjct: 68 GGMDRQILLWNV-FGDVKNYGVLNGCKGAITDLQWS-RDSRVVYCSSSDTHLMSWDAVSG 125 Query: 190 ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVA 249 + + + S ++ + + + + + K+ K +T VA Sbjct: 126 QKIRKHKGHAGVVNALDV-LKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVA 184 Query: 250 LNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQK 309 + +D +KIWDLR H+ + + S DG+ LL+ Sbjct: 185 IAQQGTQVFI-GGIDGAIKIWDLRNNHCSHVLK---GHKDIITSLAISKDGSSLLSNSMD 240 Query: 310 SEIRVYSASQWDCPL-GL-IPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 + +R++ + L I H Q + AW + G + Sbjct: 241 NTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATG 300 Query: 368 ELRTIDVFDGNSGKMMCQLYDPESSGISS 396 +LR + G+ G + + P I S Sbjct: 301 DLRYV--LPGHEGSVNHVDFHPHQDIILS 327 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 42/279 (15%), Positives = 91/279 (32%), Gaps = 34/279 (12%) Query: 150 IKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ----DFKGNILRVFASSDTINIWFC 205 ++ G + +F+P + F + M+ L D K + + Sbjct: 44 LQMFGHTAEVLVARFDPSGS-YFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITD---- 98 Query: 206 SLDVSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVD 264 L S SR+V + +++ + + G+++ + H V + + L + S D Sbjct: 99 -LQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDD 157 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPL 324 T+K+WD R + ++ ++P+ A + G ++ I+++ C Sbjct: 158 CTMKVWDSRSK----DCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSH 213 Query: 325 GLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYEL----RTIDVFDGNSG 380 L H A + ++ D + R + +F+G Sbjct: 214 VLKGHKDIIT------SLAISKDGSSLLSNS-MDNTVRIFDVKPFASAQRQLQIFEGAIH 266 Query: 381 KMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS 419 L S N A + ++ +WS Sbjct: 267 GQEHNLL----GVAWSRN----SRFVGAGSSDKNVYVWS 297 >5OQL-J nrPDB Length = 912 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 93/289 (32%), Gaps = 55/289 (19%) Query: 123 HPSTVAVGSKGGDIMLW--NFGIKDKPTFIKGIGAGGSITGLKF-------------NPL 167 +A GSK LW + + G S+ + NPL Sbjct: 444 SGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPL 503 Query: 168 NT--NQFYASSMEGTTRLQDF-----KGNILRVFASSDTINIWFCSLDVSASSRMVVTGD 220 + + S + + +D KG L + +LD+S + ++ + Sbjct: 504 DHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASAS 563 Query: 221 NVGNVILLNMDGKELW-NLRMHKKKVTHVALNP-------------CCDWFLATASVDQT 266 V + +++ E+ LR HK+ V V P + T S D+T Sbjct: 564 QDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKT 623 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACF---SPDGA------RLLTTDQKSEIRVYSA 317 +K+W+L +F H H V + S D + + + + ++V+ A Sbjct: 624 IKLWNLSDYTCIRTFE---GHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Query: 318 SQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTP 366 + + L H R + A H + N++ D Sbjct: 681 NTGETECTLDNHEDRLW------TLAVHSKTNILASAGS-DSKVTFWRD 722 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 89/306 (29%), Gaps = 56/306 (18%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTR 182 P+ V S+G + F + G I L + + + ++ R Sbjct: 350 SPADVVSSSEGILLE----------PFRRISGTHDEILDLTYILPDQSMMAIATNSEDIR 399 Query: 183 LQDFK---------GNILRVFASSDTINIW------FCSLDVSASSRMVVTGDNVGNVIL 227 + K + + SLDV S + +G L Sbjct: 400 IVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARL 459 Query: 228 LNMDG-----KELWNLRMHKKKVTHVA----LNPCCD-----------WFLATASVDQTV 267 +D H + V VA + P FL + S D+ V Sbjct: 460 WRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFV 519 Query: 268 KIWDLRQVRGKA----SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323 + D+ + K S L L H +NA SP+G + Q ++++ + + Sbjct: 520 QKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQ 579 Query: 324 LGLIPHPHRHF-QHLTPIKAAW------HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFD 376 L H + P+ +V+ D K + I F+ Sbjct: 580 GILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFE 639 Query: 377 GNSGKM 382 G+S + Sbjct: 640 GHSHNV 645 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 36/320 (11%), Positives = 83/320 (25%), Gaps = 61/320 (19%) Query: 142 GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-----GNILRVFAS 196 + + G G I+ L P + S T R+ ++ Sbjct: 47 ELNTGKRLAEIQGDGEPISTLTITPSGS-HLIVCSRSLTMRIYSLAISPDYDSVEPTLVR 105 Query: 197 S-DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM---------HKKKVT 246 + L V +S ++ TG G + + ++ G + + H ++ Sbjct: 106 TTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIA 165 Query: 247 HVALNPCCD---------------------WFLATASVDQTVKIWDLRQVRGKASFLYSL 285 A + + + LA + D ++I+DL + + Sbjct: 166 VTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPK 225 Query: 286 ----PHRHPVNAACFSPDGARLLTTDQKSEI--RVYSASQWDCPLGLIPHPHRHFQHLTP 339 H V +SP+ LL+ + + ++ W L Sbjct: 226 RKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHEL--------- 276 Query: 340 IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 399 +++ + + + Q E I S Sbjct: 277 LESVGFLNEGKWMYSAGTSGVLRIWDT---------TTHHEITKKQDAKSEGEAILSAVS 327 Query: 400 FNPMGDTLASAMGYHILIWS 419 L + + ++++ Sbjct: 328 LPERSLILCAQADFTLVLYR 347 >4YCZ-A nrPDB Length = 876 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 44/259 (16%), Positives = 85/259 (32%), Gaps = 29/259 (11%) Query: 99 DSYRILQKAAPFDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 ++ R+ + D ++W HP + + +A G +++W Sbjct: 50 ETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKA 109 Query: 158 SITGLKFNPLNTNQFYAS-SMEGTTRLQDFKGN-----ILRVFASSDTINIWFCSL---- 207 S+ + ++P A S +G + +F+ N I W + Sbjct: 110 SVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGS 169 Query: 208 -------DVSASSRMVVTGDNVGNVILLNMDGKELWN------LRMHKKKVTHVALNPC- 253 S +R VTG + + + D L H V VA +P Sbjct: 170 IVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTV 229 Query: 254 -CDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEI 312 ++A+AS D+TV+IW L V +S G L + +++ Sbjct: 230 LQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKV 289 Query: 313 RVYS---ASQWDCPLGLIP 328 ++ +W+C + Sbjct: 290 TLWKENLKGEWECVKTIEE 308 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 39/284 (13%), Positives = 84/284 (29%), Gaps = 33/284 (11%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + +A S I ++ + + G G++ + + +P N ++ +G Sbjct: 29 YGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKV 88 Query: 182 RLQ-DFKGNILRVFASS-DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD--GKELWN 237 + + G R+F + ++ S + ++ + GNV +L E Sbjct: 89 LIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSI 148 Query: 238 LRMHKKKVTHVALNP----------------CCDWFLATASVDQTVKIW--DLRQVRGKA 279 H V V+ P + T D +KIW D K Sbjct: 149 FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKL 208 Query: 280 SFLYSLPHRHPVNAACFSP---DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 H V +SP + + + + +R++++ D L + Sbjct: 209 EREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTS---DPANPLQWNCKVLNFD 265 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY---ELRTIDVFDG 377 + +W N++ D E + + Sbjct: 266 AAVWRVSWSLSGNVLAASG-GDNKVTLWKENLKGEWECVKTIEE 308 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 35/119 (29%), Gaps = 11/119 (9%) Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY--SASQWDCPLGLIPHPHRHFQHL 337 + + H ++ A G RL T I+++ L H + Sbjct: 10 QVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVW--- 66 Query: 338 TPIKAAW-HPRYNLIVVGRYPDPNFKSCTPYE--LRTIDVFDGNSGKMMCQLYDPESSG 393 +W HP+Y I+ D + I F + + + P +G Sbjct: 67 ---CVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAG 122 >5WYJ-BC nrPDB Length = 817 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 43/296 (14%), Positives = 92/296 (31%), Gaps = 51/296 (17%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKP--TFIKGIGAGGSITGL----K 163 + SL +A SK ++W + + K IG ++T + Sbjct: 387 HEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNI 445 Query: 164 FNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVG 223 + +S + T + I S+DV Sbjct: 446 VSKGYPEFLLTASNDLTIKKW--------------IIPKPTASMDV-------------Q 478 Query: 224 NVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 + + + H+K + ++++P ATAS D+T KIW+L +A+ Sbjct: 479 IIKV------SEYTRHAHEKDINALSVSPNDS-IFATASYDKTCKIWNLENGELEATL-- 529 Query: 284 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA 343 H+ + F L T+ ++++S + L H + + + Sbjct: 530 -ANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTN------AVQRCS 582 Query: 344 WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 399 + + ++ D K + DG++ ++ + I S + Sbjct: 583 FINKQKQLISCGA-DGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADA 637 Score = 88.0 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 30/218 (13%), Positives = 73/218 (33%), Gaps = 18/218 (8%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168 ++ +L+ P S A S +WN +++ + + F + Sbjct: 489 AHEKDINALSVSPND-SIFATASYDKTCKIWN--LENGELEATLANHKRGLWDVSFCQYD 545 Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228 SS + T ++ + T + CS ++ +++ G G + + Sbjct: 546 K-LLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSF-INKQKQLISCGA-DGLIKIW 602 Query: 229 N-MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD--------LRQVRGKA 279 + G+ L L H ++ ++ D + +A D + W Q + K Sbjct: 603 DCSSGECLKTLDGHNNRLWALSTMNDGD-MIVSADADGVFQFWKDCTEQEIEEEQEKAKL 661 Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 ++ ++ ++ A LL +R+++ Sbjct: 662 QVEQEQSLQNYMSKGDWT--NAFLLAMTLDHPMRLFNV 697 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 37/240 (15%), Positives = 78/240 (32%), Gaps = 34/240 (14%) Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDGKELW-----NLRMHKKKVTHVA----LNPCC 254 SLD + + T I+ + H VT V ++ Sbjct: 391 LNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGY 450 Query: 255 DWFLATASVDQTVKIW---------DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 305 FL TAS D T+K W D++ ++ + H +NA SP+ + T Sbjct: 451 PEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRH--AHEKDINALSVSPNDSIFAT 508 Query: 306 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 365 ++++ + L H + +Y+ ++ D K + Sbjct: 509 ASYDKTCKIWNLENGELEATLANHKRGLWD-------VSFCQYDKLLATSSGDKTVKIWS 561 Query: 366 PYELRTIDVFDGNSGKMM-CQLYDPESSGI-----SSLNEFN-PMGDTLASAMGYHILIW 418 + +G++ + C + + I + ++ G+ L + G++ +W Sbjct: 562 LDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLW 621 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 42/223 (18%), Positives = 82/223 (36%), Gaps = 31/223 (13%) Query: 117 LAWHPTH--PSTVAVGSKGGDI---------MLWNFGIKDKPTFIK-GIGAGGSITGLKF 164 ++ +P + S VA S+ G I + + + K IT LK Sbjct: 10 ISLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKL 69 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 P S ++ K + S I+ LD ++S ++ G G+ Sbjct: 70 TPDGQ-YLTYVSQAQLLKIFHLKTGKV---VRSMKISSPSYILDADSTSTLLAVGGTDGS 125 Query: 225 VILLNMD-GKELWNLRMHKKKVTHVALNPCCD---WFLATASVDQTVKIWDLRQVRGKAS 280 +I+++++ G + + H ++ + + W LA+ + VK+WDL + + Sbjct: 126 IIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKC--- 182 Query: 281 FLYSL-PHRHPVNAACF--SPDGAR----LLTTDQKSEIRVYS 316 L++L H V PD LL+ + I ++ Sbjct: 183 -LHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 59/380 (15%), Positives = 117/380 (30%), Gaps = 47/380 (12%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPS 125 ++ T L S + + + S +I + D +TS + Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTS--------T 115 Query: 126 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFN-PLNTN--QFYASSMEGTTR 182 +AVG G I++ I++ G GG+I+ LKF LN+ + G + Sbjct: 116 LLAVGGTDGSIIV--VDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVK 173 Query: 183 LQDFKGNILRVFASSDTINIWFCSLDVSASSRM----VVTGDNVGNVILLNMDGKELWNL 238 + D T + + + +++G + L + + K+ L Sbjct: 174 VWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKL 233 Query: 239 RMH---KKKVTHVALNPCCD--WFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNA 293 ++V D + TA D ++ D + + Sbjct: 234 LKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGV 293 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI--PHPHRHFQHLTPIKAAWHPRYNLI 351 + L D L LI ++ + + ++ + +I Sbjct: 294 LPILSNSQMFLVLS-------------DQTLQLINVEEDLKNDEDTIQVTSSIAGNHGII 340 Query: 352 VVGRYPDPNFKSCTPY----ELRTIDVFD----GNSGKMMCQLYDPESSGISSLNEFNPM 403 RY P LR I V D S + ++Y+ ++SL+ Sbjct: 341 ADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDA-TED 399 Query: 404 GDTLASAMGYHI-LIWSQEE 422 G +A+A + ++W E Sbjct: 400 GLWIATASKDNTAIVWRYNE 419 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 54/402 (13%), Positives = 106/402 (26%), Gaps = 92/402 (22%) Query: 96 HTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGA 155 H+ + + F + S W +A G G + +W+ + + Sbjct: 138 HSFKGHGGTISSLKFYGQLNSKIW------LLASGDTNGMVKVWD--LVKRKCLHTLQEH 189 Query: 156 GGSITGLKF--NPLN---TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS 210 ++ GL P N + + + L DF + +N S Sbjct: 190 TSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFL 249 Query: 211 ASSR-----MVVTGD------------------------------------------NVG 223 GD + Sbjct: 250 KDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQ 309 Query: 224 NVILLNMDG---------KELWNLRMHKKKVTHVALN-PC-CDWFLATASVD-QTVKIWD 271 + L+N++ + ++ + + + P LAT S + + + D Sbjct: 310 TLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPD 369 Query: 272 LRQVRGKASFLYSL--PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 L + H +N+ + DG + T + + V+ ++ C + Sbjct: 370 LSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYA- 428 Query: 330 PHRHFQHLTPIKAAWHPRYNLIVVGRYP--------DPNFKSCTPYELRTIDVFDGNSGK 381 ++ H + A P IV YP D K + D K Sbjct: 429 --KYIGHSAAVTAVGLPN---IVSKGYPEFLLTASNDLTIKKWII--PKPTASMDVQIIK 481 Query: 382 MMCQLYDPESSGISSLNEFNPMGDTLASAMGYHI-LIWSQEE 422 + I++L +P A+A IW+ E Sbjct: 482 VSEYTRHAHEKDINAL-SVSPNDSIFATASYDKTCKIWNLEN 522 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 48/160 (30%), Gaps = 10/160 (6%) Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT 305 + VA LAT +D+ + I DL K S + A +PDG L Sbjct: 20 SAVATVSENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTY 78 Query: 306 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT 365 Q ++++ + + L+ VG D + Sbjct: 79 VSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTST-------LLAVGG-TDGSIIVVD 130 Query: 366 PYELRTIDVFDGNSGKMMCQLYDPE-SSGISSLNEFNPMG 404 F G+ G + + + +S I L + G Sbjct: 131 IENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNG 170 >3JRO-A nrPDB Length = 753 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 72/267 (26%), Gaps = 24/267 (8%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + +A S I ++ + G G + + + +P + S +G Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKELWN-- 237 + + A + S+ + +++ + G V ++ + Sbjct: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 238 -LRMHKKKVTHVALNPCC------------DWFLATASVDQTVKIWDLRQVRGKASFLYS 284 + H V + P T D VKIW + Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 199 Query: 285 L-PHRHPVNAACFSPD---GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 L H V +SP + L + Q +++ P F + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL-W 258 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPY 367 +A+W N++ + D Sbjct: 259 RASWSLSGNVLALSG-GDNKVTLWKEN 284 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 85/241 (35%), Gaps = 24/241 (9%) Query: 99 DSYRILQKAAPFDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 ++++++ + + W HP + +A S G +++W Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 100 Query: 158 SITGLKFNPLNTN-QFYASSMEGTTRLQDFKGNILR--VFASSDTINIWFCSLDVSA--- 211 S+ +++ P +S +G + +FK N + + I + S + Sbjct: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 Query: 212 --------SSRMVVTGDNVGNVILL--NMDGK---ELWNLRMHKKKVTHVALNPCC--DW 256 SR VTG V + N D + L H V VA +P Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 Query: 257 FLATASVDQTVKIWDLRQVRG--KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 +LA+ S D+T IW +G K + L + A +S G L + +++ + Sbjct: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 Query: 315 Y 315 + Sbjct: 281 W 281 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 33/112 (29%), Gaps = 9/112 (8%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA-W 344 H ++ A G RL T I+++ LI H P+ W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLI---DTLTGHEGPVWRVDW 61 Query: 345 -HPRYNLIVVGRYPDPNFKSCTPY--ELRTIDVFDGNSGKMMCQLYDPESSG 393 HP++ I+ D I V +S + + P G Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 >5XYI-g nrPDB Length = 335 Score = 103 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 53/326 (16%), Positives = 101/326 (30%), Gaps = 34/326 (10%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD---KPTFIKGIGAGGSITGLKFNP 166 + S+ H + + S+ ++W F + IG ++ + + Sbjct: 32 HNAAIESIEIDNEH-NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLS- 89 Query: 167 LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 + + SS + T RL D + ++ + S +R +++ V Sbjct: 90 RDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLG--VTFSPCNRRIISVGRDNQVK 147 Query: 227 LLNMDGKELWNLRMHKKKVTHVALNPCCD----WFLATASVDQTVKIWDLRQVRGKASFL 282 + N+ G+ L+ VT VA P D +A D V IW + + +A + Sbjct: 148 IWNILGENKAELQC-SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEK---EAKLI 203 Query: 283 YSL-PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 H + F+PDG ++T ++ ++ + H P Sbjct: 204 KEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACP-T 262 Query: 342 AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFD---GNSGKMMCQLYDPESSGISSLN 398 AW I Y + ID+ + GK + + + Sbjct: 263 QAW------ICAATYE--GIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAAD 314 Query: 399 EFNPMGDTLASAMGY-HILIWSQEEA 423 G L S I W + A Sbjct: 315 -----GSVLYSGYNDGSIRAWEVKSA 335 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 17/139 (12%), Positives = 43/139 (30%), Gaps = 22/139 (15%) Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSA----SQWDCPLGLIPHPHRHFQHLTPI 340 + H + + + L++ + V+ QW P + + ++ Sbjct: 30 VGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLS 89 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 + A H ++ + D + T +F G+ ++ + P + I S+ Sbjct: 90 RDASH-----LLTSSW-DSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISV--- 140 Query: 401 NPMGDTLASAMGYHILIWS 419 + IW+ Sbjct: 141 ---------GRDNQVKIWN 150 >5K1B-B nrPDB Length = 677 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 32/246 (13%), Positives = 90/246 (36%), Gaps = 17/246 (6%) Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASS-DTINIWFCSLDVSASSRMVV 217 + L+ +P N+ + + + R+ + + +S + W + + + + ++ Sbjct: 33 VNALQLDPA-LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLI 91 Query: 218 TGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 + + V + N G + LR HK V +A + +A+A +D+ + +WD+ + Sbjct: 92 SASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKE-LVASAGLDRQIFLWDVNTLT 150 Query: 277 GKASFLYSL------PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 + ++ ++ + + + G +++ + +RV+ + L H Sbjct: 151 ALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHT 210 Query: 331 HRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 390 +KA R + D + + + R I + + + + Sbjct: 211 DN-------VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263 Query: 391 SSGISS 396 + + S Sbjct: 264 FTHVYS 269 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 42/286 (14%), Positives = 93/286 (32%), Gaps = 28/286 (9%) Query: 100 SYRILQKAAPFDRR-ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 SY I + ++R +L P + + + I +W+ + +I + Sbjct: 18 SYVIRDEVEKYNRNGVNALQLDPAL-NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTD 76 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 N ++S + T ++ + + + +L + +V + Sbjct: 77 WVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHK--DYVKALAYAKDKELVAS 134 Query: 219 GDNVGNVILLNMDG----------KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 268 + L +++ +L +K + +A+N + + S ++ ++ Sbjct: 135 AGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLR 193 Query: 269 IWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIP 328 +WD R A + H V A + DG + L+ IR++S Q C Sbjct: 194 VWDPRTC---AKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRV 250 Query: 329 HPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDV 374 H + W + N Y + +LR D+ Sbjct: 251 HD----------EGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 286 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 63/185 (34%), Gaps = 16/185 (8%) Query: 242 KKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGA 301 + V + L+P + TA D ++IW + Q + H VN +G Sbjct: 30 RNGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 302 RLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNF 361 L++ + ++V++A + C L H +KA + + +V D Sbjct: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKD-------YVKALAYAKDKELVASAGLDRQI 141 Query: 362 KSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHI-LIWSQ 420 T+ ++ + I SL N +G + S + +W Sbjct: 142 FLWDVN---TLTALTASNNTVTTSSLSGNKDSIYSL-AMNQLGTIIVSGSTEKVLRVW-- 195 Query: 421 EEART 425 + RT Sbjct: 196 -DPRT 199 >6EOJ-D nrPDB Length = 470 Score = 101 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 40/297 (13%), Positives = 93/297 (31%), Gaps = 48/297 (16%) Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT 218 I +++ P ++ G L + + + ++ S S +++ Sbjct: 96 IPAIQWTPEGRR-LVVATYSGEFSLWNASSFTFETLMQAH--DSAVTTMKYSHDSDWMIS 152 Query: 219 GDNVGNVILLNMDGKELWNLRM-HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 277 GD G + + + + + H + + +A + F T S D +KIW+ + Sbjct: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF-VTCSDDNILKIWNFSNGKQ 211 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 + H V + + P+ + + + + ++++ +C ++ F+H Sbjct: 212 ERVLS---GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL-----KFKHT 263 Query: 338 TPIKAAWHPRYNLIVVGRYPDP------------NFKSCTPYELRTIDVFDGNSGKMMCQ 385 + NL++ + T++ N Sbjct: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLA 323 Query: 386 LYDP---------------------ESSGISSLNEFNPMGDTLASAMGYH-ILIWSQ 420 YD I+SL +NP+G A+A I W++ Sbjct: 324 CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL-SYNPVGHIFATAAKDRTIRFWTR 379 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 33/252 (13%), Positives = 70/252 (27%), Gaps = 50/252 (19%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168 D T++ + + G G I +W SI + F+ + Sbjct: 133 AHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNF--SMVKEIDAAHTESIRDMAFSSND 189 Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228 + +F S + ++ +F S ++ C D ++ + V L Sbjct: 190 S-KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC--DWHPEMGLIASASKDNLVKLW 246 Query: 229 NM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR-------------- 273 + G + ++ K V P L S D++ +++D+R Sbjct: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 Query: 274 -----------------------------QVRGKASFLYSLPHRHPVNAACFSPDGARLL 304 Q + H + + ++P G Sbjct: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 Query: 305 TTDQKSEIRVYS 316 T + IR ++ Sbjct: 367 TAAKDRTIRFWT 378 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 35/197 (17%), Positives = 72/197 (36%), Gaps = 11/197 (5%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 + + S WHP +A SK + LW+ + + I + +F Sbjct: 213 RVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRF 269 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA-SSRMVVTGDNVG 223 P N A S + + R+ D + ++ + D + + +L+ + M G Sbjct: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD--YMTLEWHPINESMFTLACYDG 327 Query: 224 NVILLNMDGKE----LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKA 279 ++ ++ L H K +T ++ NP ATA+ D+T++ W + Sbjct: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFWTRARPIDPN 386 Query: 280 SFLYSLPHRHPVNAACF 296 ++ + +N F Sbjct: 387 AYDDPTYNNKKINGWFF 403 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/185 (13%), Positives = 53/185 (28%), Gaps = 33/185 (17%) Query: 250 LNPCCDWFL------ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 + P + + A D+ + + K + L S +H + A ++P+G RL Sbjct: 55 VEPETSYTIDIMPPNAYRGRDRVINL------PSKFTHLSSNKVKHVIPAIQWTPEGRRL 108 Query: 304 LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKS 363 + E +++AS + + ++ G D K Sbjct: 109 VVATYSGEFSLWNASS------FTFETLMQAHDSAVTTMKYSHDSDWMISGD-ADGMIKI 161 Query: 364 CTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHIL-IWSQEE 422 P + + D F+ + +IL IW+ Sbjct: 162 WQP----NFSMVKEIDAAHTESIRD---------MAFSSNDSKFVTCSDDNILKIWNFSN 208 Query: 423 ARTRK 427 + + Sbjct: 209 GKQER 213 >5WBU-D nrPDB Length = 328 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 39/295 (13%), Positives = 87/295 (29%), Gaps = 14/295 (4%) Query: 104 LQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLK 163 + D + +L P ++ + I +++ + I G +I + Sbjct: 37 TRTVQHQDSQVNALEVTPD--RSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVG 94 Query: 164 FNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVG 223 F+ Y + T R+ D + L+ +N + + + ++ GD G Sbjct: 95 FHEDGRWM-YTGGEDCTARIWDLRSRNLQC-QRIFQVNAPINCVCLHPNQAELIVGDQSG 152 Query: 224 NVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF- 281 + + ++ + + +T ++P + A S +W+L G Sbjct: 153 AIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST-GNCYVWNLTGGIGDEVTQ 211 Query: 282 ----LYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 H FSPD L T +++ S + L + Sbjct: 212 LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESS 271 Query: 338 TP--IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 390 A+ IV D + + G+ ++C ++ Sbjct: 272 RGWMWGCAFSGDSQYIVTASS-DNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 325 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 42/256 (16%), Positives = 83/256 (32%), Gaps = 22/256 (8%) Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL 227 + + + T R I + + +L+V+ M+ ++ + Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICT--RTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRM 69 Query: 228 LNMDGKE---LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS 284 +++ + + K + V + W + T D T +IWDLR + ++ Sbjct: 70 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRW-MYTGGEDCTARIWDLRSRNLQCQRIFQ 128 Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAW 344 + P+N C P+ A L+ DQ I ++ D LIP P ++ A Sbjct: 129 V--NAPINCVCLHPNQAELIVGDQSGAIHIWDLKT-DHNEQLIPEP-----EVSITSAHI 180 Query: 345 HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG 404 P Y + Y +++ + P + + F+P Sbjct: 181 DPD------ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS 234 Query: 405 DTLASAMGYHI-LIWS 419 LA+ IW Sbjct: 235 TLLATCSADQTCKIWR 250 >6BX3-A nrPDB Length = 314 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 87/252 (34%), Gaps = 27/252 (10%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168 R + L W P +A S + + + IG + L FN Sbjct: 52 SHARPFSELCWSPD-GQCIATASDDFSVEIIHLSY---GLLHTFIGHTAPVISLTFNRKG 107 Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILL 228 N + SSM+ + ++ D L S+ + + + ++ S ++ +G G + + Sbjct: 108 -NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN-DSSILSSGSYDGLIRIF 165 Query: 229 NM-DGKELWNLRMHKKK--------VTHVALNPCCDWFLATASVDQTVKIWD------LR 273 + G L L K ++ V + + L S+D VKIWD +R Sbjct: 166 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK-SLDGVVKIWDCIGGCVVR 224 Query: 274 QVRGKASFLYSLPHRHPVNAACFSPDGA---RLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 + + L H ++ +P+ +++ + +I +++ L Sbjct: 225 TFQVQPLEKGVLHHSCGMDFL--NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 282 Query: 331 HRHFQHLTPIKA 342 + H + I Sbjct: 283 YHHSSPVMSIHC 294 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 46/268 (17%), Positives = 87/268 (32%), Gaps = 19/268 (7%) Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL-RVFASSDTINIWFCSLDVSASSRMVVT 218 T K +P QF A + + D + + +S F L S + + T Sbjct: 16 TCAKISPD--GQFLAITQGLNILIYDINRRTVSQTLVTSHA--RPFSELCWSPDGQCIAT 71 Query: 219 GDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 + +V ++++ L H V + N + L T+S+D+++KIWD Sbjct: 72 ASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLM 130 Query: 279 ASFLYSLPHRHPVNAACFS-PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH- 336 + H V + D + L + IR++ A C L ++ Sbjct: 131 KTIS---AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 187 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGN--SGKMMCQLYDPESSGI 394 + PI ++ + D K + F ++ S G+ Sbjct: 188 VVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH-----HSCGM 242 Query: 395 SSLNEFNPMGDTLASAMGY-HILIWSQE 421 LN + + S I W+ + Sbjct: 243 DFLNPEDGSTPLVISGYENGDIYCWNSD 270 >3JRP-A nrPDB Length = 379 Score = 99.5 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 72/267 (26%), Gaps = 24/267 (8%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + +A S I ++ + G G + + + +P + S +G Sbjct: 22 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 81 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKELWN-- 237 + + A + S+ + +++ + G V ++ + Sbjct: 82 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 141 Query: 238 -LRMHKKKVTHVALNPCC------------DWFLATASVDQTVKIWDLRQVRGKASFLYS 284 + H V + P T D VKIW + Sbjct: 142 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 201 Query: 285 L-PHRHPVNAACFSPD---GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 L H V +SP + L + Q +++ P F + Sbjct: 202 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL-W 260 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPY 367 +A+W N++ + D Sbjct: 261 RASWSLSGNVLALSG-GDNKVTLWKEN 286 Score = 97.6 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 85/241 (35%), Gaps = 24/241 (9%) Query: 99 DSYRILQKAAPFDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 ++++++ + + W HP + +A S G +++W Sbjct: 43 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 102 Query: 158 SITGLKFNPLNTN-QFYASSMEGTTRLQDFKGNILR--VFASSDTINIWFCSLDVSA--- 211 S+ +++ P +S +G + +FK N + + I + S + Sbjct: 103 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 162 Query: 212 --------SSRMVVTGDNVGNVILL--NMDGK---ELWNLRMHKKKVTHVALNPCC--DW 256 SR VTG V + N D + L H V VA +P Sbjct: 163 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 222 Query: 257 FLATASVDQTVKIWDLRQVRG--KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 +LA+ S D+T IW +G K + L + A +S G L + +++ + Sbjct: 223 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 282 Query: 315 Y 315 + Sbjct: 283 W 283 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 33/112 (29%), Gaps = 9/112 (8%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA-W 344 H ++ A G RL T I+++ LI H P+ W Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLI---DTLTGHEGPVWRVDW 63 Query: 345 -HPRYNLIVVGRYPDPNFKSCTPY--ELRTIDVFDGNSGKMMCQLYDPESSG 393 HP++ I+ D I V +S + + P G Sbjct: 64 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 115 >3W15-A nrPDB Length = 368 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 84/244 (34%), Gaps = 40/244 (16%) Query: 117 LAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS 176 LAW+ +H + V V G + L++ K+ P + +N +N F +SS Sbjct: 68 LAWNESHENQVLVAQGDGTLRLFDTTFKEFP-IAIFKEHEREVFSCNWNLVNRQNFLSSS 126 Query: 177 MEGTTRLQD-FKGNILRVFA--------SSDTINIWF-------------CSL---DVSA 211 +G+ ++ + L D +N + S Sbjct: 127 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 186 Query: 212 SSR---MVVTGDNVGNVILLNM-DGKELWNLRMHKK-KVTHVALNPCCDWFLATASVDQT 266 + + +G++ ++ + + GK N +H + N + +AT VD Sbjct: 187 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 246 Query: 267 VKIWDLRQVRGKASFLYSL--------PHRHPVNAACFSP-DGARLLTTDQKSEIRVYSA 317 ++IWD+R + L++ H + +SP L++ R++ Sbjct: 247 IRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRD 306 Query: 318 SQWD 321 D Sbjct: 307 LSND 310 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 45/264 (17%), Positives = 77/264 (29%), Gaps = 58/264 (21%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLW-------------------------NFGIK 144 +R S W+ + S G I +W N I Sbjct: 105 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 164 Query: 145 DKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK---GNILRVFASSDTIN 201 K +F + +F+P + N + S L D + G F + Sbjct: 165 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 224 Query: 202 IWFCSLDVSASSRMVV-TGDNVGNVILLNMD-----------GKELWNL-RMHKKKVTHV 248 C D + VV TG + + ++ + + H + V Sbjct: 225 ALTC--DFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKV 282 Query: 249 ALNPCCDWFLATASVDQTVKIW-DLRQVRGKASFLYS------------LPHRHPVNAAC 295 +P L +AS D T +IW DL K ++ + H V A Sbjct: 283 TWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD 342 Query: 296 FSPDGA--RLLTTDQKSEIRVYSA 317 +S G + +T + V++ Sbjct: 343 WSLWGKPGYVASTAWDGNLFVWNG 366 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 107/317 (33%), Gaps = 56/317 (17%) Query: 147 PTFIKGIGAGGSITGLKFNPLNTNQFYAS-----SMEGTTRLQ----DFKGNILRVFASS 197 + ++ G S G++++P N+ + + G +L D G I+ V + Sbjct: 1 GSMLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFL 60 Query: 198 DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE--LWNLRMHKKKVTHVALNPCCD 255 ++ + + S ++++V G + L + KE + + H+++V N Sbjct: 61 TQDCLFDLAWNESHENQVLVAQG-DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNR 119 Query: 256 WFLATASVDQTVKIWD-LRQVRGKASFLYSLP-----------------------HRHPV 291 ++S D ++KIW LR+ L +R+ V Sbjct: 120 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 292 NAACFSP-DGARLLTTDQKSEIRVYS--ASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRY 348 A FSP D +L+ S ++ + H L + ++ Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG-----LEALTCDFNKYR 234 Query: 349 NLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM---MCQLYDPESSGI-SSLNEFNP-- 402 +V D + I + + N G++ C P + G+ ++P Sbjct: 235 PYVVATGGVDNAIRIWD------IRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 288 Query: 403 MGDTLASAMGYHILIWS 419 ++++ IW Sbjct: 289 SNILMSASYDMTCRIWR 305 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 12/115 (10%), Positives = 31/115 (26%), Gaps = 15/115 (13%) Query: 86 VQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLW------ 139 + L ++ +S I + + W P H + + S +W Sbjct: 251 DIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 310 Query: 140 --------NFGIKDKPTFIKGIGAGGSITGLKFNPLNT-NQFYASSMEGTTRLQD 185 N K + + G ++ +++ +G + + Sbjct: 311 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >4BZK-B nrPDB Length = 297 Score = 98.0 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 72/267 (26%), Gaps = 24/267 (8%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + +A S I ++ + G G + + + +P + S +G Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKELWN-- 237 + + A + S+ + +++ + G V ++ + Sbjct: 80 LIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 238 -LRMHKKKVTHVALNPCC------------DWFLATASVDQTVKIWDLRQVRGKASFLYS 284 + H V + P T D VKIW + Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLEST 199 Query: 285 L-PHRHPVNAACFSPD---GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 L H V +SP + L + Q +++ P F + Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL-W 258 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPY 367 +A+W N++ + D Sbjct: 259 RASWSLSGNVLALSG-GDNKVTLWKEN 284 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 85/241 (35%), Gaps = 24/241 (9%) Query: 99 DSYRILQKAAPFDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 ++++++ + + W HP + +A S G +++W Sbjct: 41 ETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 100 Query: 158 SITGLKFNPLNTN-QFYASSMEGTTRLQDFKGNILR--VFASSDTINIWFCSLDVSA--- 211 S+ +++ P +S +G + +FK N + + I + S + Sbjct: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 160 Query: 212 --------SSRMVVTGDNVGNVILL--NMDGK---ELWNLRMHKKKVTHVALNPCC--DW 256 SR VTG V + N D + L H V VA +P Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 220 Query: 257 FLATASVDQTVKIWDLRQVRG--KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 +LA+ S D+T IW +G K + L + A +S G L + +++ + Sbjct: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 280 Query: 315 Y 315 + Sbjct: 281 W 281 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 33/112 (29%), Gaps = 9/112 (8%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA-W 344 H ++ A G RL T I+++ LI H P+ W Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEG--ETHKLI---DTLTGHEGPVWRVDW 61 Query: 345 -HPRYNLIVVGRYPDPNFKSCTPY--ELRTIDVFDGNSGKMMCQLYDPESSG 393 HP++ I+ D I V +S + + P G Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYG 113 >5OQL-L nrPDB Length = 557 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 39/233 (16%), Positives = 81/233 (34%), Gaps = 11/233 (4%) Query: 97 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG-A 155 ++ L+ FD A P + G G + +++ G + +K Sbjct: 85 SIRKREPLKTIGRFDSEAHCGEIRPD-GRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIH 143 Query: 156 GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSL-DVSASSR 214 + K++P + S + T RL D N + T + + SA+S Sbjct: 144 KQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSN 203 Query: 215 MVVTGDNVGNVILLNMD--GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 ++V+G V + + G + + H + V P LA + + + DL Sbjct: 204 LLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASGN--AISVLDL 260 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 + H+ V + + G R+++ ++V+ + W+ G Sbjct: 261 VAAK---PLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAG 310 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 64/204 (31%), Gaps = 32/204 (15%) Query: 233 KELWNLRMHKK----KVTHVALNPC-CDWFLATASVDQTVKIWDLRQVR-GKASFLYSLP 286 + + H ++H++ L ++S+ K DL V G ++S+ Sbjct: 28 RSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIR 87 Query: 287 HRHPVNAA----------CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 R P+ PDG L+ + ++V+ Q + L H Sbjct: 88 KREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVIL----KTWHIH 143 Query: 337 LTPIKAA-WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGIS 395 P+ W P ++ D + +F G++ + C + P S+ Sbjct: 144 KQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSA--- 200 Query: 396 SLNEFNPMGDTLASAM-GYHILIW 418 + L S + +W Sbjct: 201 -------NSNLLVSGSYDETVRVW 217 >4J0W-A nrPDB Length = 343 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 37/239 (15%), Positives = 85/239 (35%), Gaps = 26/239 (10%) Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDT--------INIW 203 G SIT L P ++ F +++ + + G L V + + Sbjct: 11 RGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 69 Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATAS 262 + +S+ + + +GD +++ + L+ H+ V+ +A L + S Sbjct: 70 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQLYSTS 128 Query: 263 VDQTVKIWDLRQVRGKASFLYSL-PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 321 D++VK+W++ + S++ +L H+ V A + + +RV+ + Sbjct: 129 HDRSVKVWNV----AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE- 183 Query: 322 CPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG 380 L+ + H+ + H +V D + + R + + G Sbjct: 184 --SQLVFYGHQGSIDCIHLINEEH------MVSGADDGSVALWGLSKKRPLALQREAHG 234 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 93/296 (31%), Gaps = 46/296 (15%) Query: 24 SRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASW 83 S L + P AKK A+G P C+ + G + RS + + + Sbjct: 45 SGRKLHVIPRAKK-GAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEA------- 96 Query: 84 PSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGI 143 Q L+T +R F R + S + +WN + Sbjct: 97 ---QSC---QHLYTFTGHRDAVSGLAFRRGTH----------QLYSTSHDRSVKVWN--V 138 Query: 144 KDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFAS-SDTINI 202 + G ++ L A +GT R+ VF +I+ Sbjct: 139 AENSYVETLFGHQDAVAALDALSRECC-VTAGGRDGTVRVWKIPEESQLVFYGHQGSIDC 197 Query: 203 WFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLR--MHKK----------KVTHVAL 250 + +V+G + G+V L + K L+ H ++ VA Sbjct: 198 IHL-----INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAA 252 Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTT 306 D +AT S V++W + + L +P +N+ FS G L+ Sbjct: 253 LLNTD-LVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 28/199 (14%), Positives = 58/199 (29%), Gaps = 28/199 (14%) Query: 229 NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG--------KAS 280 + ++ LR H+ +T + + P +A+ D ++ W + R K + Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGA 59 Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 H V S DG L + D+ I ++ A H + Sbjct: 60 EGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD-------AV 112 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 R + D + K E ++ G+ +++L+ Sbjct: 113 SGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQD------------AVAALDAL 160 Query: 401 NPMGDTLASAMGYHILIWS 419 + A + +W Sbjct: 161 SRECCVTAGGRDGTVRVWK 179 >4GGA-A nrPDB Length = 420 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 86/237 (36%), Gaps = 13/237 (5%) Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL 227 ++ A +++ + L + + + S+ + G + V L Sbjct: 114 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 173 Query: 228 LNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 ++ ++ L N+ H +V ++ N + L++ S + D+R + L Sbjct: 174 WDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS--G 228 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 345 H V ++PDG L + + + V+ ++ + QH +KA AW Sbjct: 229 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVKAVAWC 285 Query: 346 PRYNLIVV--GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 P + ++ G D + + + D +S ++ L+ P + S + F Sbjct: 286 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGF 341 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 76/225 (33%), Gaps = 16/225 (7%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + + L+ R SL+W+ ++ GS+ G I + + + G Sbjct: 176 VQQQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQ 231 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDF---KGNILRVFASSDTINIWFCSLDVSASSR 214 + GL++ P + + + +G + + + S Sbjct: 232 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 290 Query: 215 MVVTG--DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLAT-ASVDQTVKIW 270 ++ TG + ++ + N+ G L + H + V + +P ++ + IW Sbjct: 291 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 349 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 + A H V + SPDGA + + +R++ Sbjct: 350 KYPTM---AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 86/237 (36%), Gaps = 13/237 (5%) Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL 227 ++ A +++ + L + + + S+ + G + V L Sbjct: 68 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 127 Query: 228 LNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 ++ ++ L N+ H +V ++ N + L++ S + D+R + L Sbjct: 128 WDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS--G 182 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 345 H V ++PDG L + + + V+ ++ + QH +KA AW Sbjct: 183 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVKAVAWC 239 Query: 346 PRYNLIVV--GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 P + ++ G D + + + D +S ++ L+ P + S + F Sbjct: 240 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGF 295 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 76/225 (33%), Gaps = 16/225 (7%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + + L+ R SL+W+ ++ GS+ G I + + + G Sbjct: 130 VQQQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQ 185 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDF---KGNILRVFASSDTINIWFCSLDVSASSR 214 + GL++ P + + + +G + + + S Sbjct: 186 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 244 Query: 215 MVVTG--DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLAT-ASVDQTVKIW 270 ++ TG + ++ + N+ G L + H + V + +P ++ + IW Sbjct: 245 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 303 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 + A H V + SPDGA + + +R++ Sbjct: 304 KYPTM---AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 >5G04-R nrPDB Length = 499 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 86/237 (36%), Gaps = 13/237 (5%) Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL 227 ++ A +++ + L + + + S+ + G + V L Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 252 Query: 228 LNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 ++ ++ L N+ H +V ++ N + L++ S + D+R + L Sbjct: 253 WDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS--G 307 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 345 H V ++PDG L + + + V+ ++ + QH +KA AW Sbjct: 308 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVKAVAWC 364 Query: 346 PRYNLIVV--GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 P + ++ G D + + + D +S ++ L+ P + S + F Sbjct: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGF 420 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 76/225 (33%), Gaps = 16/225 (7%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + + L+ R SL+W+ ++ GS+ G I + + + G Sbjct: 255 VQQQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQ 310 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDF---KGNILRVFASSDTINIWFCSLDVSASSR 214 + GL++ P + + + +G + + + S Sbjct: 311 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 Query: 215 MVVTG--DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLAT-ASVDQTVKIW 270 ++ TG + ++ + N+ G L + H + V + +P ++ + IW Sbjct: 370 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 428 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 + A H V + SPDGA + + +R++ Sbjct: 429 KYPTM---AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 >4N14-A nrPDB Length = 314 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 86/237 (36%), Gaps = 13/237 (5%) Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL 227 ++ A +++ + L + + + S+ + G + V L Sbjct: 30 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQL 89 Query: 228 LNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 ++ ++ L N+ H +V ++ N + L++ S + D+R + L Sbjct: 90 WDVQQQKRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLS--G 144 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 345 H V ++PDG L + + + V+ ++ + QH +KA AW Sbjct: 145 HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWV---PLQTFTQHQGAVKAVAWC 201 Query: 346 PRYNLIVV--GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 P + ++ G D + + + D +S ++ L+ P + S + F Sbjct: 202 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHGF 257 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 76/225 (33%), Gaps = 16/225 (7%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + + L+ R SL+W+ ++ GS+ G I + + + G Sbjct: 92 VQQQKRLRNMTSHSARVGSLSWNSYI---LSSGSRSGHIHHHDVRVAEHH-VATLSGHSQ 147 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDF---KGNILRVFASSDTINIWFCSLDVSASSR 214 + GL++ P + + + +G + + + S Sbjct: 148 EVCGLRWAPDGR-HLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 206 Query: 215 MVVTG--DNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLAT-ASVDQTVKIW 270 ++ TG + ++ + N+ G L + H + V + +P ++ + IW Sbjct: 207 VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 265 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 + A H V + SPDGA + + +R++ Sbjct: 266 KYPTM---AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 >6ELZ-p nrPDB Length = 460 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 29/207 (14%), Positives = 75/207 (36%), Gaps = 15/207 (7%) Query: 124 PSTVAVGS-KGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTR 182 + ++ + K + + + I+ + + + F+ + Y+ S + T + Sbjct: 254 NNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIK 313 Query: 183 LQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD---GKELWN-- 237 D + T + S+ ++ ++ G + ++ L + ++ Sbjct: 314 TWDLVTARC---IDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQ 370 Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYS-----LPHRHPVN 292 L HK V+ + P ++ L + S D TVK+WD+R + V Sbjct: 371 LIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVF 430 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQ 319 A ++ + +++ Q +I++ Sbjct: 431 AVKWA-EKVGIISAGQDKKIQINKGDN 456 Score = 74.5 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 68/224 (30%), Gaps = 55/224 (24%) Query: 203 WFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATAS 262 W SLDV S+ +++G G V ++ G H + V L +A Sbjct: 105 WVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKYISNTR--LVSAG 162 Query: 263 VDQTVKIWDLRQVRGKASFLYSL--------------------PHRHPVNAACFSPDGAR 302 D+T+++W + K + H+ PV + S D +R Sbjct: 163 NDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSR 221 Query: 303 LLTTDQKSEIRVYSASQWDC----PLGLIPHPHRHF------------------------ 334 +L+ + I +S + PL I +P+ Sbjct: 222 ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLS 281 Query: 335 ---QHLTPI-KAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDV 374 H P+ + + N + D K+ R ID Sbjct: 282 LLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT 325 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 52/318 (16%), Positives = 88/318 (27%), Gaps = 83/318 (26%) Query: 167 LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 226 + + S +G R D GN+ + S + I S+ +V+ N + Sbjct: 113 DGSKHIISGSYDGIVRTWDLSGNV-QKQYSGHSGPIRAVKY---ISNTRLVSAGNDRTLR 168 Query: 227 LLNM------------------------DGKELWNLRMHKKKVTHVALNPCCDWFLATAS 262 L DGK L L HK V + ++ + + +AS Sbjct: 169 LWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS--DNSRILSAS 226 Query: 263 VDQTVKIW--------------DLRQ---------------------VRGKASFLYSLPH 287 D ++ W D+ +R +A H Sbjct: 227 YDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESH 286 Query: 288 RHPVNAACF-SPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHP 346 PV F S D + Q I+ + C + + A Sbjct: 287 TAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCI-------DTRTTSYSLLSIAQLS 339 Query: 347 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT 406 NL+ G + T ++ R G S K+ Q + +SSL+ Sbjct: 340 TLNLLACGSS----ARHITLHDPRV-----GASSKVTQQQLIGHKNFVSSLDTCPENEYI 390 Query: 407 LASAMGY-HILIWSQEEA 423 L S + +W Sbjct: 391 LCSGSHDGTVKVWDVRST 408 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 40/328 (12%), Positives = 87/328 (26%), Gaps = 76/328 (23%) Query: 95 LHTLDSYRILQKA-APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWN------------- 140 + T D +QK + ++ + + + + LW Sbjct: 127 VRTWDLSGNVQKQYSGHSGPIRAVKY--ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQ 184 Query: 141 --------FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR 192 I+D T G + + + + ++ ++S + + + Sbjct: 185 AQEDDDDEVNIEDGKTLAILEGHKAPV--VSIDVSDNSRILSASYDNSIGFWSTIYKEMT 242 Query: 193 VFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNP 252 V + IN + +A R +T G + L L H V V + Sbjct: 243 VVDPLEDINNPNNKISTAARKRRKLT-MKDGTIR----RRAPLSLLESHTAPVEQVIFDS 297 Query: 253 CCDWFLATASVDQTVKIWDLRQVRG----------------------------------- 277 + + S D T+K WDL R Sbjct: 298 TDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHD 357 Query: 278 -------KASFLYSLPHRHPVNAACFSPDGAR-LLTTDQKSEIRVYSASQWDCPLGLIPH 329 K + + H++ V++ P+ L + ++V+ + Sbjct: 358 PRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITRE 417 Query: 330 PHRHFQHL--TPIKAAWHPRYNLIVVGR 355 + + W + +I G+ Sbjct: 418 DKSVQKGVNDKVFAVKWAEKVGIISAGQ 445 Score = 35.2 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 20/153 (13%), Positives = 48/153 (31%), Gaps = 23/153 (15%) Query: 279 ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 S+L S + V++ +++ +R + S ++ H Sbjct: 94 PSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN--------VQKQYSGHSG 145 Query: 339 PIKAAWHPRYNLIVVGRYPDPNFKSCT------------PYELRTIDVFDGNSGKMMCQL 386 PI+A + +V D + + D + GK + + Sbjct: 146 PIRAVKYISNTRLVSAG-NDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTL-AI 203 Query: 387 YDPESSGISSLNEFNPMGDTLASAMGYHILIWS 419 + + + S++ + L+++ I WS Sbjct: 204 LEGHKAPVVSIDVSDNS-RILSASYDNSIGFWS 235 Score = 34.4 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 11/85 (12%), Positives = 26/85 (30%), Gaps = 8/85 (9%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI------GAGGS 158 Q+ +SL P + + GS G + +W+ I G Sbjct: 369 QQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDK 428 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRL 183 + +K+ ++ + ++ Sbjct: 429 VFAVKWA--EKVGIISAGQDKKIQI 451 >2AQ5-A nrPDB Length = 402 Score = 93.0 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 48/324 (14%), Positives = 102/324 (31%), Gaps = 60/324 (18%) Query: 87 QQGLQQSFLHTLDSYRILQKAAPFDRRATSLAW-------HPTHPSTVAVGSKGGDIMLW 139 +Q ++ S + D R + W +P + + S GG ++ Sbjct: 3 RQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVL 62 Query: 140 NFGIKDK--PTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASS 197 G + G + + + P N N + S + T + + Sbjct: 63 PLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI----------- 111 Query: 198 DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWF 257 +V+ + + L H K+V VA +P Sbjct: 112 -------------PDGGLVL------------PLREPVITLEGHTKRVGIVAWHPTAQNV 146 Query: 258 LATASVDQTVKIWDLRQVRGKASFLYSLP---HRHPVNAACFSPDGARLLTTDQKSEIRV 314 L +A D + +WD+ G + + +L H + + +S DGA + T+ + +RV Sbjct: 147 LLSAGCDNVILVWDV----GTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Query: 315 YSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG--RYPDPNFKSCTPYELRTI 372 + ++ R + P+ A + ++ G R + L Sbjct: 203 IEPRKG----TVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEP 258 Query: 373 DVFDG--NSGKMMCQLYDPESSGI 394 S ++ +DP+++ + Sbjct: 259 LSLQELDTSSGVLLPFFDPDTNIV 282 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 73/226 (32%), Gaps = 20/226 (8%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTF-------IKGIGAGGSITGL 162 +AW P + + +A GS+ +M+W I D I G + + Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWE--IPDGGLVLPLREPVITLEGHTKRVGIV 137 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 222 ++P N ++ + + D + D S+D S ++ T Sbjct: 138 AWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRD 197 Query: 223 GNVILLNMDGKELWNLRMH----KKKVTHVALNPCCDWFLATA---SVDQTVKIWDLRQV 275 V ++ + + + V V ++ L T ++ V +WD + + Sbjct: 198 KRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS--EGKILTTGFSRMSERQVALWDTKHL 255 Query: 276 RGKASFLYSLPHRHPVNAACFSPDGARLLTTDQ-KSEIRVYSASQW 320 + L L V F PD + + S IR + + Sbjct: 256 E-EPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE 300 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 64/214 (29%), Gaps = 28/214 (13%) Query: 217 VTGDNVGNVILLNMDGK---ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 +G V+ L G+ + + H V +A P D +A+ S D TV +W++ Sbjct: 53 ASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIP 112 Query: 274 QVRGKASFLYSL----PHRHPVNAACFSPD-GARLLTTDQKSEIRVYSASQWDCPLGLIP 328 + H V + P LL+ + I V+ L L P Sbjct: 113 DGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP 172 Query: 329 HPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYD 388 H T W LI CT + + V + G ++ + Sbjct: 173 DVHPD----TIYSVDWSRDGALI------------CTSCRDKRVRVIEPRKGTVVAEKDR 216 Query: 389 PESSGISSLNEFNPMGDTLASA----MGYHILIW 418 P F G L + + +W Sbjct: 217 PHEGTRPVHAVFVSEGKILTTGFSRMSERQVALW 250 >5OQL-d nrPDB Length = 446 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 83/215 (38%), Gaps = 14/215 (6%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 TSL++H +T A S G I +W+ I+ +IT + FN + T+ Sbjct: 154 GPYTSLSFH-RSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSV 212 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLD--VSASSRM-VVTGDNVGNVILL 228 + + + + L D + N+ + F + M + N+ + Sbjct: 213 IGSVATDRSIILFDLRTNMPVIKTVLH-----FACNRIVFNPMEAMNLAVASEDHNIYIF 267 Query: 229 NMDG--KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 + K L + H V V +P + L + S D+T+++W R+ G + +Y Sbjct: 268 DARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLW--RRDAGHSRDVYHTK 324 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 321 V ++ D +LT +R++ A+ + Sbjct: 325 RMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 85/253 (33%), Gaps = 22/253 (8%) Query: 122 THPSTVAVGSKGGDIMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGT 180 T+ + + G I LW+ + T I GG T L F+ + N F ASS +G Sbjct: 119 TNDKKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFH-RSANTFAASSGQGC 176 Query: 181 TRLQDFKGNILRVFASSDTINIWFCSLDVS-ASSRMVVTGDNVGNVILLNMDGKE-LWNL 238 R+ D + + + + + + ++ + ++IL ++ + Sbjct: 177 IRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKT 236 Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP 298 +H + NP LA AS D + I+D R + H V FSP Sbjct: 237 VLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQK--GHVAAVMDVEFSP 293 Query: 299 DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA----WHPRYNLIVVG 354 G L++ IR++ R H ++ W I+ G Sbjct: 294 TGEELVSGSYDRTIRLWRRDAGH---------SRDVYHTKRMQRVFRTMWTMDSKYILTG 344 Query: 355 RYPDPNFKSCTPY 367 D N + Sbjct: 345 S-DDGNVRLWRAN 356 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 35/281 (12%), Positives = 84/281 (29%), Gaps = 26/281 (9%) Query: 150 IKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDV 209 G G + + + + N + S +G ++ D + + NI L Sbjct: 60 QLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNI-VKGLTF 118 Query: 210 SASSRMVVTGDNVGNVILLNMDGKELWNLRM--HKKKVTHVALNPCCDWFLATASVDQTV 267 + +++ + + + T ++ + A +S + Sbjct: 119 TNDKKLLSCATDGIKLWDPYASPSNTTPIATWQEGGPYTSLSFH-RSANTFAASSGQGCI 177 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQWDCPLGL 326 +IWDL + + CF+ + + + + I ++ + Sbjct: 178 RIWDLEHSTA-GQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKT 236 Query: 327 IPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386 + H + ++P + + D N ++ R D + + Sbjct: 237 VL-------HFACNRIVFNPMEAMNLAVASEDHNIYI---FDARNFDKALNIQKGHVAAV 286 Query: 387 YDPESSGISSLNEFNPMGDTLASAMGYH-ILIWSQEEARTR 426 D EF+P G+ L S I +W ++ +R Sbjct: 287 MD---------VEFSPTGEELVSGSYDRTIRLWRRDAGHSR 318 >6CHG-A nrPDB Length = 312 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 29/285 (10%), Positives = 86/285 (30%), Gaps = 16/285 (5%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 ++ P + ++ +A+ ++ + I I L + Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDMLV---YEISSSKMMKLTTTHKECINCLCW 62 Query: 165 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 +P ++ + S + T + +R T + + ++ + + Sbjct: 63 SP-DSKCIASGSEDFTVEITHIIYGRIRRLM-GHTAPVISIC--YNNKGNILCSSSMDES 118 Query: 225 VILL-NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 + + G L + H V + + L++ S D ++I+D + Y Sbjct: 119 IKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTY 178 Query: 284 S---LPHRH--PVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI---PHPHRHFQ 335 + P++ FS +G LL + ++++ ++ + + Sbjct: 179 DKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLK 238 Query: 336 HLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG 380 + ++ + + +V+ + Y + D Sbjct: 239 YNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHR 283 >3ODT-A nrPDB Length = 313 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 57/333 (17%), Positives = 111/333 (33%), Gaps = 39/333 (11%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIK-DKPTFIKGI 153 + Y++ D+ + S VA S+ G + LW+ + G Sbjct: 2 IDPFTGYQLSATLKGHDQDVRDVVA--VDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQ 59 Query: 154 GAGGSITGLKFNPLNTNQFYAS--SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA 211 G + + ++ + +M L G N+ S Sbjct: 60 GF---LNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQ--- 113 Query: 212 SSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 +V++G + +G ++NL+ H V + + TAS D+T+K+W Sbjct: 114 -DGVVISGSWDKTAKVWK-EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW- 170 Query: 272 LRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 K +S H V DG + + I++ D H Sbjct: 171 ---QNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGH-- 224 Query: 332 RHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPES 391 F + + P +++ G E RT+ ++ +G + + P Sbjct: 225 ESFVYCIKLL----PNGDIVSCG-------------EDRTVRIWSKENGSLKQVITLPAI 267 Query: 392 SGISSLNEFNPMGDTLASAMGYHILIWSQEEAR 424 S I S++ + GD + + + I+SQE++R Sbjct: 268 S-IWSVDCMS-NGDIIVGSSDNLVRIFSQEKSR 298 >1NR0-A nrPDB Length = 611 Score = 91.5 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 73/217 (33%), Gaps = 14/217 (6%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 T++A A G G++ +W+ G + + ++ + Sbjct: 59 SHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRI 118 Query: 172 FYASSME---GTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRM-VVTGDNVGNVIL 227 G L D + + + +N S+D S +++G + V + Sbjct: 119 AAVGEGRERFGHVFLFDTGTSNGNLTGQARAMN----SVDFKPSRPFRIISGSDDNTVAI 174 Query: 228 L-NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD----LRQVRGKASFL 282 K H K V V NP A+ D T+ +++ + + L Sbjct: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 Query: 283 YSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 ++ H V +SPDG ++ + I++++ + Sbjct: 234 KNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 84/255 (32%), Gaps = 14/255 (5%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 T K +P + + G R+ D + + + + + S Sbjct: 57 EHSHQTTVAKTSPSGY-YCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 Query: 214 RMVVTGD----NVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 + + G+V L + G NL + + V P + + + S D TV I Sbjct: 116 KRIAAVGEGRERFGHVFLFD-TGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 ++ + K++F H V++ ++PDG+ +T I +Y+ Sbjct: 175 FEGPPFKFKSTF---GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDD 231 Query: 330 PHRHFQHLTPI-KAAWHPRYNLIVVGRYPDPNFKSC---TPYELRTIDVFDGNSGKMMCQ 385 ++ H + W P I D K T +TI V + + Sbjct: 232 SLKNVAHSGSVFGLTWSPDGTKIASAS-ADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 Query: 386 LYDPESSGISSLNEF 400 ++ ++ S N F Sbjct: 291 IWTKQALVSISANGF 305 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 47/315 (14%), Positives = 94/315 (29%), Gaps = 67/315 (21%) Query: 97 TLDSYRILQKAAP-FDRRATSLAWHPTHPSTVAVGSKG----GDIMLWNFGIKDKPTFIK 151 T + IL+ P F ++W +A +G G + L++ G + Sbjct: 88 TTQTTHILKTTIPVFSGPVKDISWDSES-KRIAAVGEGRERFGHVFLFDTGTSNGNL--- 143 Query: 152 GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA 211 G ++ + F P + + S + T + + + T + S+ + Sbjct: 144 -TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVH--SVRYNP 200 Query: 212 SSRMVVTGDNVGNVILL-NMDGKELWNLR-------MHKKKVTHVALNPCCDWFLATASV 263 + + G ++L +DG + H V + +P +A+AS Sbjct: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK-IASASA 259 Query: 264 DQTVKIWDLRQVRGKASFLYS--------------------------------------- 284 D+T+KIW++ ++ + + Sbjct: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQV 319 Query: 285 -LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA 343 H + A S DG L + D + I + S I + H T I Sbjct: 320 RYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG------ISNRVFPDVHATMITGI 373 Query: 344 WHPRYNLIVVGRYPD 358 + + D Sbjct: 374 KTTSKGDLFTVSWDD 388 Score = 71.8 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 39/251 (15%), Positives = 83/251 (33%), Gaps = 11/251 (4%) Query: 118 AWHPTHPSTVAVGSKGGDIML-WNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS 176 H T + + SKG + W+ +K P G+ + ++ K + ++ Sbjct: 364 DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVAN-KLSSQPLGLAVSAD 422 Query: 177 MEGTTRLQDFKGNILRVFASSD-TINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL 235 + I ++ I+ + +S + V G V + + G + Sbjct: 423 GDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASV 482 Query: 236 WNLRM--HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNA 293 ++ H ++T VA + + +AT + + + + A H V Sbjct: 483 SEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIP-YSVANNFELAHTNSWTFHTAKVAC 541 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 +SPD RL T + + V++ +I + + W ++ Sbjct: 542 VSWSPDNVRLATGSLDNSVIVWNM-NKPSDHPIIIKGAHAMSSVNSV--IWLNETTIVSA 598 Query: 354 GRYPDPNFKSC 364 G+ D N K Sbjct: 599 GQ--DSNIKFW 607 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 54/158 (34%), Gaps = 13/158 (8%) Query: 168 NTNQFYASSMEGTTRLQDFKG-NILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV- 225 + + + G ++ V I S+ S + +V D V Sbjct: 459 DKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEI--TSVAFSNNGAFLVATDQSRKVI 516 Query: 226 -----ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 + W H KV V+ +P + LAT S+D +V +W++ + Sbjct: 517 PYSVANNFELAHTNSWTF--HTAKVACVSWSPD-NVRLATGSLDNSVIVWNMNKPSDHPI 573 Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318 + VN+ + + +++ Q S I+ ++ Sbjct: 574 IIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNVP 610 >5A31-R nrPDB Length = 386 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 44/267 (16%), Positives = 91/267 (34%), Gaps = 23/267 (8%) Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 TSL+W S +AVG G + +++ + + G + L +N + Sbjct: 135 TSLSWIGA-GSHLAVGQANGLVEIYD--VMKRKCIRTLSGHIDRVACLSWNNH---VLTS 188 Query: 175 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE 234 S + +D + C L + + + +G N V + K Sbjct: 189 GSRDHRILHRDVRMPDPFFETIESHTQE-VCGLKWNVADNKLASGGNDNVVHVYEGTSKS 247 Query: 235 -LWNLRMHKKKVTHVALNPCCDWFLATAS--VDQTVKIWDLRQVRGKASFLYSLPHRHPV 291 + HK V +A +P LAT D+ +KIW++ + + + + Sbjct: 248 PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNT----SIKMSDIDSGSQI 303 Query: 292 NAACFSPDGARLLTTD--QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 +S + L+T+ K + ++ + D L H R + Sbjct: 304 CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRV------LHLTLSNDGT 357 Query: 350 LIVVGRYPDPNFKSCTPYELRTIDVFD 376 +V G D + +++ +++F Sbjct: 358 TVVSGA-GDETLRYWKLFDVSVLNLFT 383 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 82/286 (28%), Gaps = 28/286 (9%) Query: 117 LAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS 176 + W T VA+G ++ T L + + Sbjct: 98 IDWSSTDVLAVALGKS-----IFLTDNNTGDVVHL-CDTENEYTSLSWIGAGS-HLAVGQ 150 Query: 177 MEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV--ILLNMDGKE 234 G + D S + L + + ++ +G + + M Sbjct: 151 ANGLVEIYDVMKRKCIRTLSGHIDRV--ACLSWN--NHVLTSGSRDHRILHRDVRMPDPF 206 Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 294 + H ++V + N + LA+ D V ++ + K+ L H+ V A Sbjct: 207 FETIESHTQEVCGLKWNVADNK-LASGGNDNVVHVY---EGTSKSPILTFDEHKAAVKAM 262 Query: 295 CFSPDGARLLT---TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI 351 +SP +L +++++ + Q W N + Sbjct: 263 AWSPHKRGVLATGGGTADRRLKIWNV----NTSIKMSDIDSGSQ---ICNMVWSKNTNEL 315 Query: 352 VVGR-YPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 V Y N + I + G+S +++ + + + S Sbjct: 316 VTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVS 361 >5L9T-R nrPDB Length = 493 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 57/335 (17%), Positives = 109/335 (32%), Gaps = 48/335 (14%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 +K F ++ P + V+ S L K + I+ + F Sbjct: 123 EKKGLFTYSLSTKRSSPDDGNDVSPYS------LSPVSNKSQKLLRSPRKPTRKISKIPF 176 Query: 165 ----NPLNTNQFY------------ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLD 208 P + FY + + L + + S+ Sbjct: 177 KVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVG 236 Query: 209 VSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 S +V G + G V + + GK+L L H +V +A N L++ S D+ + Sbjct: 237 WSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE---QLSSGSRDRMI 293 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 327 D+R ++ HR V +S D L + +++ V++ S L Sbjct: 294 LQRDIRTPPLQSERRLQ-GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS------LS 346 Query: 328 PHPHRHFQHLTPIKA-AWHPRY-NLIVVGRYP-DPNFKSCTPYELRTIDVFDGNSGKMMC 384 P ++ +HL +KA AW P L+ G D + + + D ++ Sbjct: 347 PV-QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCID-TGSQVCN 404 Query: 385 QLYDPESSGISSLNEFNPMGDTLASAMGYHILIWS 419 + ++ + S + + IL+W Sbjct: 405 LAWSKHANELVSTHGY----------SQNQILVWK 429 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 77/247 (31%), Gaps = 49/247 (19%) Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 173 TS+ W + VAVG+ G + +W+ G + L + N Q Sbjct: 232 VTSVGWS-ERGNLVAVGTHKGFVQIWDAA--AGKKLSMLEGHTARVGALAW---NAEQLS 285 Query: 174 ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG- 232 + S + +D + L+ C L S +++ +G N +++ N Sbjct: 286 SGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL 345 Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATAS--VDQTVKIWDLRQVR-----GKASFLYSL 285 + H V +A +P LA+ D+ ++ W+ + S + +L Sbjct: 346 SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNL 405 Query: 286 -----------------------------------PHRHPVNAACFSPDGARLLTTDQKS 310 H + V SPDG ++T Sbjct: 406 AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE 465 Query: 311 EIRVYSA 317 +R ++ Sbjct: 466 TLRFWNV 472 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 72/198 (36%), Gaps = 16/198 (8%) Query: 81 ASWPSVQQGLQQSF-LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLW 139 +S + LQ+ L S R LQ + L W H +A G +++W Sbjct: 285 SSGSRDRMILQRDIRTPPLQSERRLQ---GHRQEVCGLKWSTDH-QLLASGGNDNKLLVW 340 Query: 140 NFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS--MEGTTRLQDFKGNILRVFASS 197 N + ++ + ++P + + R + + Sbjct: 341 NHSSLSP--VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT 398 Query: 198 DTINIWFCSLDVSASSRMVVT--GDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCC 254 C+L S + +V+ G + +++ ++ L H +V ++A++P Sbjct: 399 G---SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDG 455 Query: 255 DWFLATASVDQTVKIWDL 272 + + T + D+T++ W++ Sbjct: 456 EA-IVTGAGDETLRFWNV 472 >5WLC-LU nrPDB Length = 489 Score = 88.0 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 62/389 (15%), Positives = 118/389 (30%), Gaps = 94/389 (24%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKA-----------APFDRRA 114 ++I R+ + +++ S LH + R KA PF + Sbjct: 3 IKTIKRSADDYVPVKSTQESQMPRNLNPELHPFERAREYTKALNATKLERMFAKPFVGQL 62 Query: 115 T--------SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL---- 162 ++A + + +A GS G I WN +++ F+ G +TGL Sbjct: 63 GYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE--FVSFKAHYGLVTGLCVTQ 120 Query: 163 -KFN---PL--NTNQFYASSMEGTTRLQDF--------------KGNILRVFASSDTINI 202 +F+ P + N + S + T +L + Sbjct: 121 PRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGES 180 Query: 203 WFCSLDVSASSRMVVTGDNVGNVILLNMDG-KELWNLRMHKKKVTHVALNPCCDWFLATA 261 F +D + TG + L +++ K + +L +T + N LA+ Sbjct: 181 AFQGIDSHRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILAST 238 Query: 262 SVDQTVKIWDLRQVRGKASFLYSL------------------------------------ 285 D ++ ++DLR + ++ Sbjct: 239 GSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSL 298 Query: 286 ----PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 H V FSP G ++T IR+Y + + + QH+ +K Sbjct: 299 NVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHG---HSREIYHTKRMQHVFQVK 355 Query: 342 AAWHPRYNLIVVGRYPDPNFKSCTPYELR 370 + +Y I+ G D N + Sbjct: 356 YSMDSKY--IISGS-DDGNVRLWRSKAWE 381 >3BG0-A nrPDB Length = 316 Score = 87.6 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 33/296 (11%), Positives = 83/296 (28%), Gaps = 33/296 (11%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGTT 181 + + +A S + +++ + G G + + + +P+ N + S + Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKELWNLR 239 + + + S+ + ++ G + G + LL G+ W ++ Sbjct: 84 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 Query: 240 ----MHKKKVTHVALN----------------PCCDWFLATASVDQTVKIWDLRQVRGKA 279 H V+ P A+ D +K+W + Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 203 Query: 280 SFLYSLPHRHPVNAACFSPD----GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQ 335 H V ++P + + + Q + +++ P F Sbjct: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS-SNTWSPKLLHKFN 262 Query: 336 HLTPIKAAWHPRYNLIVVGRYPDPNFKSCT---PYELRTIDVFDGNSGKMMCQLYD 388 + +W N++ V D + I + G + + + Sbjct: 263 DVV-WHVSWSITANILAVSG-GDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTE 316 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 78/248 (31%), Gaps = 35/248 (14%) Query: 110 FDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLN 168 + +AW HP + + +A S +++W + G S+ + + P + Sbjct: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHD 115 Query: 169 TNQFYAS-SMEGTTRLQDFKGNIL---RVFASSDTIN----IWF-----CSLDVSASSR- 214 A S +G L + G + ++ TI W SL S + Sbjct: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQK 175 Query: 215 -----MVVTGDNVGNVILL----NMDGKELWNLRMHKKKVTHVALNPC---CDWFLATAS 262 +G + L + KE L H V VA P +A+ S Sbjct: 176 PNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS 235 Query: 263 VDQTVKIW---DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS- 318 D V IW D L+ V +S L + +++ ++ S Sbjct: 236 QDGRVFIWTCDDASSNTWSPKLLHKF--NDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 Query: 319 --QWDCPL 324 QW C Sbjct: 294 DGQWVCIS 301 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 32/117 (27%), Gaps = 11/117 (9%) Query: 284 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPL--GLIPHPHRHFQHLTPIK 341 H ++ A G RL T ++++ L L H +Q Sbjct: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ------ 62 Query: 342 AAW-HPRYNLIVVGRYPDPNFKSCTPYE--LRTIDVFDGNSGKMMCQLYDPESSGIS 395 AW HP Y I+ D G+ + + P G+ Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLI 119 >5FA5-B nrPDB Length = 367 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 102/308 (33%), Gaps = 35/308 (11%) Query: 28 LELEPEAKKLCAKGSGP------SRRCDSDCLWVGLAGPQILPPCRSIVRTL------HQ 75 +E + EA + + G+ S RC + LW+ PC + + Sbjct: 52 MERQLEAARYRSDGALLLGASSLSGRCWAGSLWL------FKDPCAAPNEGFCSAGVQTE 105 Query: 76 HKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHP--------THPSTV 127 + +W + L S ++ + + + + + + Sbjct: 106 AGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 165 Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK 187 GSK I +W+ + +T + +P + F + S + L D + Sbjct: 166 VSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 223 Query: 188 GNILRVFASSDTINIWFCSLDVSAS-SRMVVTGDNVGNVILLNMDG-KELWNLRMHKKKV 245 SL S + V GD G V L++ + + +H + V Sbjct: 224 CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCV 283 Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLL 304 T + +P FLA+ S D ++ + D + S HR V A +SP + + L Sbjct: 284 TGLVFSPHSVPFLASLSEDCSLAVLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLT 339 Query: 305 TTDQKSEI 312 T ++ Sbjct: 340 TVGWDHQV 347 Score = 74.5 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 42/229 (18%), Positives = 80/229 (34%), Gaps = 15/229 (6%) Query: 145 DKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGN---ILRVFASSDTIN 201 + G+ + L + + +S G L + N I+ F + + Sbjct: 95 EGFCSA-GVQTEAGVADLTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDD 151 Query: 202 IWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLAT 260 I ++ V +S V+G + + ++ + L + R H +VT VA +P D + Sbjct: 152 I-VSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLS 210 Query: 261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLT-TDQKSEIRVYSASQ 319 S D + +WD R + + S P P + + P + + D+ + + Sbjct: 211 CSEDNRILLWDTRCPKPASQIGCSAPGYLP-TSLAWHPQQSEVFVFGDENGTVSLVDTKS 269 Query: 320 WDCPLGLIPHPH-----RHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKS 363 C L H H P A+ +L V+ F+S Sbjct: 270 TSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS 318 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 59/182 (32%), Gaps = 14/182 (7%) Query: 216 VVTGDNVGNVILLNMDGKELWNLRM-----HKKKVTHVALNPCCDWFLATASVDQTVKIW 270 ++ + G V L +D E + H V+ V++ + S D +K+W Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT-QAVSGSKDICIKVW 177 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPD-GARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 DL Q + H V SP + L+ + + I ++ + Sbjct: 178 DLAQ---QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS 234 Query: 330 PHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 389 + P AWHP+ + + V + + +S + ++ P Sbjct: 235 APGYL----PTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSP 290 Query: 390 ES 391 S Sbjct: 291 HS 292 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 20/192 (10%), Positives = 52/192 (27%), Gaps = 24/192 (12%) Query: 242 KKKVTHVALNPCCDWFLATASVDQTV---KIW---DLRQVRGKASFLYSLPHRHPVNAAC 295 ++++ L +S+ +W D + + V Sbjct: 53 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLT 112 Query: 296 FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGR 355 + + +L + ++ + + LI ++H + V Sbjct: 113 WVGERG-ILVASDSGAVELWELDENE---TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSG 168 Query: 356 YPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHI 415 D K + + + ++ ++ C P + L+ + I Sbjct: 169 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF-----------LSCSEDNRI 217 Query: 416 LIWSQEEARTRK 427 L+W + R K Sbjct: 218 LLW---DTRCPK 226 >4BH6-A nrPDB Length = 308 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 86/260 (33%), Gaps = 23/260 (8%) Query: 115 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 174 TSL+W S +AVG G + +++ + + G + L +N + Sbjct: 66 TSLSWIGA-GSHLAVGQANGLVEIYD--VMKRKCIRTLSGHIDRVACLSWNNH---VLTS 119 Query: 175 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE 234 S + +D + C L + + + +G N V + K Sbjct: 120 GSRDHRILHRDVRMPDPFFETIESHTQE-VCGLKWNVADNKLASGGNDNVVHVYEGTSKS 178 Query: 235 -LWNLRMHKKKVTHVALNPCCDWFLATAS--VDQTVKIWDLRQVRGKASFLYSLPHRHPV 291 + HK V +A +P LAT D+ +KIW++ + + + + Sbjct: 179 PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNT----SIKMSDIDSGSQI 234 Query: 292 NAACFSPDGARLLTTD--QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 +S + L+T+ K + ++ + D L H R + Sbjct: 235 CNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRV------LHLTLSNDGT 288 Query: 350 LIVVGRYPDPNFKSCTPYEL 369 +V G D + ++ Sbjct: 289 TVVSGA-GDETLRYWKLFDK 307 Score = 65.3 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 82/286 (28%), Gaps = 28/286 (9%) Query: 117 LAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS 176 + W T VA+G ++ T L + + Sbjct: 29 IDWSSTDVLAVALGKS-----IFLTDNNTGDVVHL-CDTENEYTSLSWIGAGS-HLAVGQ 81 Query: 177 MEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV--ILLNMDGKE 234 G + D S + L + + ++ +G + + M Sbjct: 82 ANGLVEIYDVMKRKCIRTLSGHIDRV--ACLSWN--NHVLTSGSRDHRILHRDVRMPDPF 137 Query: 235 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 294 + H ++V + N + LA+ D V ++ + K+ L H+ V A Sbjct: 138 FETIESHTQEVCGLKWNVADNK-LASGGNDNVVHVY---EGTSKSPILTFDEHKAAVKAM 193 Query: 295 CFSPDGARLLT---TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI 351 +SP +L +++++ + Q W N + Sbjct: 194 AWSPHKRGVLATGGGTADRRLKIWNV----NTSIKMSDIDSGSQ---ICNMVWSKNTNEL 246 Query: 352 VVGR-YPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 V Y N + I + G+S +++ + + + S Sbjct: 247 VTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVS 292 >4PSX-B nrPDB Length = 401 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 47/256 (18%), Positives = 87/256 (33%), Gaps = 36/256 (14%) Query: 88 QGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGI---K 144 +GLQ TL ++ A F + GS + LW G Sbjct: 150 EGLQS----TLKFHKDNGYALSFSTLVKG---------RLLSGSDDHTVALWEVGSGGDP 196 Query: 145 DKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWF 204 KP I K++ N + F S + ++ D + N + F Sbjct: 197 TKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN--TTIDTVKCPQPF 254 Query: 205 CSLDVSA-SSRMVVTGDNVGNVILLNMDGKE--LWNLRMHKKKVTHVALNPCCDWFLATA 261 +L S SS ++ V L ++ + L ++ H+ V ++ + D + ++ Sbjct: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSS 314 Query: 262 SVDQTVKIWDLRQVRGKAS-----------FLYSLPHRHPVNAACFSPDGARLLTTDQKS 310 D + +WDL+Q+ + + + HR VN +P L+ + ++ Sbjct: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEE 374 Query: 311 EIRVYSASQWDCPLGL 326 I W C L Sbjct: 375 NI----LQVWKCSHSL 386 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 90/278 (32%), Gaps = 22/278 (7%) Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 IT ++ P + N + +GTT L + N + S Sbjct: 115 YEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKF-HKDNGYALSFSTLVK 173 Query: 213 SRMVVTGDNVGNVILLNMDG-----KELWNL-RMHKKKVTHVALNPCCDWFLATASVDQT 266 R++ +G + V L + K + +H + + T S D Sbjct: 174 GRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPD-GARLLTTDQKSEIRVYSASQWDCPLG 325 +KI D+R + + ++ P N FS L S + +Y PL Sbjct: 233 LKINDVR---ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 Query: 326 LIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQ 385 H H + ++ + H ++ G D ++ D + + Sbjct: 290 ---HMSGHEDAVNNLEFSTHVDGVVVSSGS--DNRLMMWDLKQIGAEQTPDDAEDGV-PE 343 Query: 386 LYDPESSGISSLNEFNPMGDT---LASAMGYHIL-IWS 419 L + SS+N+F+ +ASA +IL +W Sbjct: 344 LIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 >4XFV-A nrPDB Length = 792 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 49/317 (15%), Positives = 96/317 (30%), Gaps = 50/317 (15%) Query: 126 TVAVGSKGGDIMLWN-FGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ 184 + G I LW+ +K + G +T ++F P +++ ++S + ++ Sbjct: 32 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIW 90 Query: 185 DFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKK 243 F + L+ + + +L S ++ G G + + + + H+ Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEF 148 Query: 244 KVTHVALNPCC---------DWFLATASVDQTVKIWDL---RQVRGKASFLYSL-PHRHP 290 + P C + LA + V I K + L H Sbjct: 149 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 208 Query: 291 VNAACFS----PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHP 346 V + F P L + Q IR++ D LI + LT + + Sbjct: 209 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND----LIDDSEEDSKKLTLLSNKQYK 264 Query: 347 RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT 406 D + +E + G+ ISSL Sbjct: 265 FQ--------IDDELRVGINFE----ALIMGHDDW------------ISSLQWHESRLQL 300 Query: 407 LASAMGYHILIWSQEEA 423 LA+ +++W +E Sbjct: 301 LAATADTSLMVWEPDET 317 Score = 51.8 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 32/203 (15%), Positives = 60/203 (29%), Gaps = 19/203 (9%) Query: 147 PTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCS 206 P K G G IT L +P + ++ + + + + Sbjct: 553 PEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL 611 Query: 207 ----LDVSASSRMVVTGDNVGNVILLNMDGK------ELWNLRMHKKKVTHVALNP-CCD 255 L S + +++ L + + N + H + + P Sbjct: 612 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 671 Query: 256 WFLATASVDQTVKIW-DLRQVRGKASFLYSLPHRHPVNAACFS----PDGARLLTTDQKS 310 TAS D+TVK+W ++ S+ H V A + + + Sbjct: 672 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 731 Query: 311 EIRVYSASQWDCPLGLIPHPHRH 333 EI +YS + LI + Sbjct: 732 EIYLYSYTLGK--FELITQLNED 752 Score = 51.4 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 44/261 (16%), Positives = 80/261 (30%), Gaps = 68/261 (26%) Query: 98 LDSYRILQKAAPFDRRATSLAW-HPTHPST--VAVGSKGGDIMLWNFGIKD--------- 145 ++ R++ + + SLA+ H P + GS+ I LW I D Sbjct: 193 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 Query: 146 ------KPTFIKG----------------IGAGGSITGLKFNPLNTNQFYASSMEGTTRL 183 K +G I+ L+++ + Q A++ + + + Sbjct: 253 KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH-ESRLQLLAATADTSLMV 311 Query: 184 QDFKGNILRVFASSDTINIWFCSLDV---SASSRMVVTGDNVGNVILLNMDGKELWNLRM 240 + +T IW CSL + S+ TG + G L + + Sbjct: 312 WE----------PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLT 361 Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 + K T S ++W + L V +SP G Sbjct: 362 NGK----------------TGSW----RMWATKDNIICDQRLGISGATKDVTDIAWSPSG 401 Query: 301 ARLLTTDQKSEIRVYSASQWD 321 LL T R+++ +D Sbjct: 402 EYLLATSLDQTTRLFAPWIYD 422 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 26/152 (17%), Positives = 54/152 (35%), Gaps = 16/152 (10%) Query: 220 DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATAS-----VDQTVKIWDLRQ 274 D + +L E+ L H ++T + ++P +A+A + ++I+ Sbjct: 544 DQLQRHLLWP----EVEKLYGHGFEITCLDISPDQK-LIASACRSNNVQNAVIRIFSTEN 598 Query: 275 -VRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRH 333 + K + + H + FS DG LL+ + + ++ + D L + Sbjct: 599 WLEIKPALPF---HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP 655 Query: 334 FQHLTPIKAAWHP-RYNLIVVGRYPDPNFKSC 364 + A W P + + V D K Sbjct: 656 HTRII-WDADWAPLEFGNVFVTASRDKTVKVW 686 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 22/148 (14%), Positives = 54/148 (36%), Gaps = 12/148 (8%) Query: 206 SLDVSASSRMVVTGDNVGNVI-----LLNMDGKELWN--LRMHKKKVTHVALNPCCDWFL 258 LD+S +++ + NV + + + L H +T + + + L Sbjct: 567 CLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLL 626 Query: 259 ATASVDQTVKIW--DLRQVRGKASFLYSLPHRHPVNAACFSP--DGARLLTTDQKSEIRV 314 + D+ +W ++ + F PH + A ++P G +T + ++V Sbjct: 627 -SVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 685 Query: 315 YSASQWDCPLGLIPHPHRHFQHLTPIKA 342 + + ++ +H + +T I Sbjct: 686 WRHQKEPADDYVLEASIKHTKAVTAISI 713 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 30/195 (15%), Positives = 62/195 (31%), Gaps = 19/195 (9%) Query: 97 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG-- 154 + +++ ++ A PF + + + LW ++D ++ Sbjct: 595 STENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK 654 Query: 155 -AGGSITGLKFNPLN-TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 I + PL N F +S + T ++ + + +I +S Sbjct: 655 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIH 714 Query: 213 SRM------VVTGDNVGNVILLNMD-GK-----ELWNLRMHKKKVTHVALN---PCCDWF 257 M + G G + L + GK +L K+T + + F Sbjct: 715 DSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLF 774 Query: 258 LATASVDQTVKIWDL 272 L S D + +I+ L Sbjct: 775 LGVGSSDLSTRIYSL 789 >3JB9-g nrPDB Length = 558 Score = 86.1 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 43/305 (14%), Positives = 80/305 (26%), Gaps = 60/305 (19%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 + + L + P + GS I +W D+ G I L F+ Sbjct: 265 HTKGISCLRFFPISGHLLLSGSMDNQIKIWEVY-HDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR-MVVTGDNVGNVILL 228 + F ++S + T +L D + +SD + V + G ++ Sbjct: 324 S-FLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVK-FQVDPDKPNEFLAGTADKRILQF 381 Query: 229 NMDG-KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 287 ++ + H + + F T S D +++ W+ H Sbjct: 382 DIRSPDIVQAYDHHLGGINSITFLENGKRF-VTTSDDSSMRFWEYGTPVPIKFVADIAMH 440 Query: 288 RHP---------------------------------------------VNAACFSPDGAR 302 P FSPDG Sbjct: 441 SMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRF 500 Query: 303 LLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI-KAAWHPRY-NLIVVGRYPDPN 360 + + D + W + P H P+ A+HP+ + + D + Sbjct: 501 VFSGDSSGNACFWD---WKTCKLMAKLP----AHSGPVQSMAFHPQETSKVATSSIVDGS 553 Query: 361 FKSCT 365 K Sbjct: 554 IKYWD 558 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 61/177 (34%), Gaps = 8/177 (4%) Query: 146 KPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC 205 K G I+ L+F P++ + + SM+ ++ + + + Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHA-RPIR 314 Query: 206 SLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALN--PCCDWFLATAS 262 L S R ++ + L + + GK L + V P + Sbjct: 315 DLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGT 373 Query: 263 VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 D+ + +D+R ++ + H +N+ F +G R +TT S +R + Sbjct: 374 ADKRILQFDIRSPDIVQAYDH---HLGGINSITFLENGKRFVTTSDDSSMRFWEYGT 427 Score = 77.6 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 51/159 (32%), Gaps = 7/159 (4%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVN 292 K ++ + H K ++ + P L + S+D +KIW++ R H P+ Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQ--GHARPIR 314 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIV 352 FS DG L+T I+++ C + R +K P Sbjct: 315 DLSFSQDGRSFLSTSFDKTIKLWDTELGKCLN--CFNSDRL---TNCVKFQVDPDKPNEF 369 Query: 353 VGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPES 391 + D + +D + G + + Sbjct: 370 LAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENG 408 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 36/182 (19%), Positives = 67/182 (36%), Gaps = 14/182 (7%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 + S I+Q S+ + + S + W +G P IK + Sbjct: 383 IRSPDIVQAYDHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYGT---PVPIKFVADIA 438 Query: 158 --SITGLKFNPLNTNQFYASSMEGTTRLQDF----KGNILRVFASSDTINIWFCSLDVSA 211 S+ + P + S++ + + N +VF + + + + S Sbjct: 439 MHSMPRVALRPNGKS-IACQSLDNCIYVYSAYEKYRQNKKKVF-KGYSCSGYSLEVGFSP 496 Query: 212 SSRMVVTGDNVGNVILLNMDGKELW-NLRMHKKKVTHVALNPCCDWFLATASV-DQTVKI 269 R V +GD+ GN + +L L H V +A +P +AT+S+ D ++K Sbjct: 497 DGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKY 556 Query: 270 WD 271 WD Sbjct: 557 WD 558 >4AEZ-A nrPDB Length = 401 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 87/283 (30%), Gaps = 18/283 (6%) Query: 66 CRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTL------DSYRILQKAAPFDRRATSLAW 119 ++ T + W L + L +S L+ A R L+W Sbjct: 125 VSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW 184 Query: 120 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEG 179 + ++ GS+ G I + I + G + GL + Q + + Sbjct: 185 N---RHVLSSGSRSGAIHHHDVRIANHQ-IGTLQGHSSEVCGLAWRSDGL-QLASGGNDN 239 Query: 180 TTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG--DNVGNVILLNM-DGKELW 236 ++ D + + + F ++ S ++ TG + N G + Sbjct: 240 VVQIWDARSS-IPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVN 298 Query: 237 NLRMHKKKVTHVALNPCCDWFLATASV-DQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 + +VT + +P ++T D + IW G + H V + Sbjct: 299 TVDA-GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSS-SGLTKQVDIPAHDTRVLYSA 356 Query: 296 FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 SPDG L T ++ + D IP +T Sbjct: 357 LSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSIT 399 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 90/252 (35%), Gaps = 28/252 (11%) Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231 A ++E + + + A +D + + S+ S + G G V + +++ Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDE-STYVASVKWSHDGSFLSVGLGNGLVDIYDVE 164 Query: 232 GK-ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 + +L + H+ +V ++ N L++ S + D+R + L H Sbjct: 165 SQTKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQIGTLQ--GHSSE 219 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHP-RY 348 V + DG +L + + ++++ A H +KA AW P + Sbjct: 220 VCGLAWRSDGLQLASGGNDNVVQIWDARS-------SIPKFTKTNHNAAVKAVAWCPWQS 272 Query: 349 NLIVVGRYP-DPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 407 NL+ G D ++ D S ++ ++ P S I S + F Sbjct: 273 NLLATGGGTMDKQIHFWNAATGARVNTVDAGS-QVTSLIWSPHSKEIMSTHGFP------ 325 Query: 408 ASAMGYHILIWS 419 ++ IWS Sbjct: 326 ----DNNLSIWS 333 >5BJS-A nrPDB Length = 605 Score = 84.1 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 81/246 (32%), Gaps = 32/246 (13%) Query: 150 IKGIGAGGSIT-------GLKFNPLNTN----QFYASSMEGTT-----RLQDFKGNILRV 193 K +G GS++ +KF P + F A+S + + D N + Sbjct: 64 YKYLGDDGSVSQDLAEFFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEI 123 Query: 194 FASSDTINIWFCSLDV-----SASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTH 247 ++ N GNV + N+ GK L H + Sbjct: 124 IQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGIND 183 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL---PHRHPVNAACFSPDGARLL 304 +A +P + +A+AS D T++IW L K + L H + + + F +G +L Sbjct: 184 LATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL 243 Query: 305 TTDQKSEIRVYSASQWDCPLGLI------PHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 + I +++ ++ I PH H + +LI+ + Sbjct: 244 SAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY-GDLILSRACHE 302 Query: 359 PNFKSC 364 Sbjct: 303 DTIVLW 308 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 63/184 (34%), Gaps = 26/184 (14%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 186 + + G++ ++N + + + +G GG I L +P N ++S + T R+ Sbjct: 151 LCIAGNEGNVKVYN--VTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSL 208 Query: 187 KGN------ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-----DGKEL 235 + + + + S+ + R V++ + + L + + E+ Sbjct: 209 APEHEKQPCVCILGGEGHSYD--LLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEI 266 Query: 236 WNL---------RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 + +H V VA D L+ A + T+ +W + L Sbjct: 267 PIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIEGFSSDDPIPGPLD 324 Query: 287 HRHP 290 P Sbjct: 325 APTP 328 >2PM9-A nrPDB Length = 416 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 33/238 (13%), Positives = 78/238 (32%), Gaps = 25/238 (10%) Query: 111 DRRATSLAWHPTHPSTVAVGSKG-GDIMLWNFGIKDKP--TFIKGIGAGGSITGLKFNPL 167 D + L W H + + G+ G + L++ + + + S+ +KFN Sbjct: 67 DSKFNDLDWS--HNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAK 124 Query: 168 NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC-------SLDVSAS-SRMVVTG 219 N + G + D + SL + S + + + Sbjct: 125 QDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASA 184 Query: 220 DNVGNVILLNMDGKELWNLRMHKKK-------VTHVALNPCCDWFLATA---SVDQTVKI 269 + + ++ K+ + ++ V +P +ATA D ++ I Sbjct: 185 GSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILI 244 Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACF-SPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 WDLR + H+ + + + D LL++ + + + +++ + Sbjct: 245 WDLRNAN-TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQF 301 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 83/264 (31%), Gaps = 26/264 (9%) Query: 176 SMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG--- 232 S + + L +S ++ F LD S +++++ + G++ L + + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANN 101 Query: 233 --KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFL------YS 284 + H V V N D LA+ + + IWD+ + S S Sbjct: 102 AINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQS 161 Query: 285 LPHRHPVNAACFSPDGARL-LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA 343 + V + ++ A + + + ++ + L Sbjct: 162 MSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVE 221 Query: 344 WHPRYNL---IVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLN-E 399 WHP+ + G DP+ N+ + L GI SL+ Sbjct: 222 WHPKNSTRVATATGSDNDPSILIWDLR----------NANTPLQTLNQGHQKGILSLDWC 271 Query: 400 FNPMGDTLASAMGYHILIWSQEEA 423 L+S +L+W+ E A Sbjct: 272 HQDEHLLLSSGRDNTVLLWNPESA 295 Score = 62.2 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 81/231 (35%), Gaps = 22/231 (9%) Query: 108 APFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFG-IKDKPTFIKGIGAG------GSIT 160 + ++ ++ + +A G G+I +W+ + P+ + G + Sbjct: 110 SNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVI 169 Query: 161 GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRV-FASSDTINIWFCSLDV------SASS 213 L +N + F ++ + D K + + + + L V +++ Sbjct: 170 SLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTR 229 Query: 214 RMVVTG-DNVGNVILLNMDGKE--LWNL-RMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 TG DN ++++ ++ L L + H+K + + + L ++ D TV + Sbjct: 230 VATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLL 289 Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTT-DQKSEIRVYSASQ 319 W+ + F + F+P+ L ++I V + Sbjct: 290 WNPESAEQLSQFP---ARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQN 337 Score = 58.3 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 24/189 (12%), Positives = 57/189 (30%), Gaps = 11/189 (5%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSI----TG 161 ++ SLAW+ + A +W+ K + + I + Sbjct: 160 QSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSV 219 Query: 162 LKFNPLNTNQFYA---SSMEGTTRLQDFKGNI--LRVFASSDTINIWFCSLDVSASSRMV 216 ++++P N+ + S + + + D + L+ I ++ Sbjct: 220 VEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDW-CHQDEHLL 278 Query: 217 VTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 275 ++ V+L N ++L P A AS D +++ L+ + Sbjct: 279 LSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNL 338 Query: 276 RGKASFLYS 284 + Sbjct: 339 TNTLDEQET 347 >5OV3-A nrPDB Length = 381 Score = 82.2 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 40/288 (13%), Positives = 91/288 (31%), Gaps = 28/288 (9%) Query: 103 ILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGL 162 I + + SL W + S + W+ + + I + Sbjct: 59 IAKIISAHIHPVCSLCWS-RDGHKLVSASTDNIVSQWD--VLSGDCDQRFRFPS-PILKV 114 Query: 163 KFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNV 222 +++P + N+ M+ + + V D ++ + + TG+ Sbjct: 115 QYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVA-SFDRRGEYIYTGNAK 173 Query: 223 GNVILLNMDGK------ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV- 275 G +++L D + + + + + FL + D+ ++++D R++ Sbjct: 174 GKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLIN-TADRIIRVYDGREIL 232 Query: 276 ----RGKA---SFLYSLPHRHPVNAACFSPDGARLLTTD-QKSEIRVYSASQWDCPLGLI 327 G+ L L +R P CFS DG ++ ++ + ++ S + L Sbjct: 233 TCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILH 292 Query: 328 PHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVF 375 + AWHP +I ++ F Sbjct: 293 GTRGELLLDV-----AWHPVRPIIASISS--GVVSIWAQNQVENWSAF 333 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 33/145 (22%), Positives = 54/145 (37%), Gaps = 13/145 (8%) Query: 257 FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYS 316 LA D + IWD RG A + H HPV + C+S DG +L++ + + + Sbjct: 39 LLAVGCNDGRIVIWDFLT-RGIAKIIS--AHIHPVCSLCWSRDGHKLVSASTDNIVSQWD 95 Query: 317 ASQWDCPLGLIPHPHRHFQHLTPI-KAAWHP-RYNLIVVGRYPDPNFKSCTPYELRTIDV 374 DC + F+ +PI K +HP N ++V + Sbjct: 96 VLSGDC--------DQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLP 147 Query: 375 FDGNSGKMMCQLYDPESSGISSLNE 399 D +S + +D I + N Sbjct: 148 VDDDSDLNVVASFDRRGEYIYTGNA 172 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 51/149 (34%), Gaps = 12/149 (8%) Query: 209 VSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 + ++ G N G +++ + + + H V + + L +AS D V Sbjct: 33 FNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDG-HKLVSASTDNIV 91 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQWDCPLGL 326 WD+ F + P+ + P D ++L KS + + S D + Sbjct: 92 SQWDVLSGDCDQRFRFP----SPILKVQYHPRDQNKVLVCPMKSAPVMLTLS--DSKHVV 145 Query: 327 IPHPHRHFQHLTPIKAAWHPRYNLIVVGR 355 +P + A++ R I G Sbjct: 146 LPVDD---DSDLNVVASFDRRGEYIYTGN 171 Score = 33.3 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 10/78 (12%), Positives = 17/78 (21%), Gaps = 9/78 (11%) Query: 295 CFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI-KAAWHPRYNLIVV 353 F+ G L I ++ + H H P+ W + +V Sbjct: 32 TFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIH-------PVCSLCWSRDGHKLVS 84 Query: 354 GRYPDPNFKSCTPYELRT 371 D Sbjct: 85 AS-TDNIVSQWDVLSGDC 101 >4U1E-I nrPDB Length = 347 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 98/269 (36%), Gaps = 39/269 (14%) Query: 150 IKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ-DFKGNILRVFASSDTINIWFCSLD 208 IK G +T +K+N + ++ S + + + G L T IW S+D Sbjct: 4 IKLTGHERPLTQVKYNKEG-DLLFSCSKDSSASVWYSLNGERLGTL-DGHTGTIW--SID 59 Query: 209 VSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATAS----V 263 V ++ VTG ++ L ++ G+ + + V V +PC ++FLA Sbjct: 60 VDCFTKYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKN 118 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC------------FSPDGARLLTTDQKSE 311 ++ I+++ R A+ + P++ +S G ++ + + Sbjct: 119 PGSINIYEI--ERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGK 176 Query: 312 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 371 I Y S + H + ++ ++ + P + +F ++ T Sbjct: 177 ISKYDVSNN---YEYVDSIDLHEKSISDMQ--FSPDLTYFITSSRDTNSF----LVDVST 227 Query: 372 IDVFDGNSGKMMCQLYDPESSGISSLNEF 400 + V C L ++ I+ L EF Sbjct: 228 LQVLKKYE--TDCPL---NTAVITPLKEF 251 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 37/316 (11%), Positives = 86/316 (27%), Gaps = 35/316 (11%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFN 165 K +R T + ++ + SK +W + + + G G+I + + Sbjct: 5 KLTGHERPLTQVKYN-KEGDLLFSCSKDSSASVW-YSL-NGERLGTLDGHTGTIWSIDVD 61 Query: 166 PLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVT------- 218 T S + + +L D S + ++ S + Sbjct: 62 CF-TKYCVTGSADYSIKLWDVSNGQCVATWKS---PVPVKRVEFSPCGNYFLAILDNVMK 117 Query: 219 --GD--------NVGNVILLNMDGKELWNLRMHKK--KVTHVALNPCCDWFLATASVDQT 266 G + L + + + + H+ T + + +A D Sbjct: 118 NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA-GHKDGK 176 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 + +D+ + H ++ FSPD +T+ + + + S Sbjct: 177 ISKYDVSNNYEYVDSIDL--HEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 Query: 327 IPHPHRHFQHLTPIK------AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSG 380 + +TP+K + + I G+ G Sbjct: 235 ETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFG 294 Query: 381 KMMCQLYDPESSGISS 396 + P+ + +S Sbjct: 295 PLNTVAISPQGTSYAS 310 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 41/308 (13%), Positives = 89/308 (28%), Gaps = 85/308 (27%) Query: 77 KLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDI 136 + S SV L L TLD + + D GS I Sbjct: 27 SCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD----------CFTKYCVTGSADYSI 76 Query: 137 MLWNFGIKDKPTFIKGIGAGGSITGLKFNP--------LNTNQFYASSME--------GT 180 LW+ + + + ++F+P L+ S+ T Sbjct: 77 KLWD--VSNGQCVATWKSPV-PVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSAT 133 Query: 181 TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG--KELWNL 238 L + + + ++ + S + ++ G G + ++ + + ++ Sbjct: 134 HELTKVSEEPIHKIITHEGLDAATVA-GWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSI 192 Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL-------------------------- 272 +H+K ++ + +P +F+ T+S D + D+ Sbjct: 193 DLHEKSISDMQFSPDLTYFI-TSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEF 251 Query: 273 -----------------RQVRGKASFLYSL---------PHRHPVNAACFSPDGARLLTT 306 + + +A F + + H P+N SP G + Sbjct: 252 IILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASG 311 Query: 307 DQKSEIRV 314 + IR+ Sbjct: 312 GEDGFIRL 319 >5WLC-LJ nrPDB Length = 513 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 93/274 (33%), Gaps = 27/274 (9%) Query: 150 IKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDV 209 + + S+T + FNP + + F +S +TR+Q F +V + S Sbjct: 33 AQLVKEHNSVTHISFNPQHPHDFAVTS---STRVQIFSSRTRQVIKTFSRFKDVVYSASF 89 Query: 210 SASSRMVVTGDNVGNVILLNMDG--KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 + +++ GD G V + + L ++ + + LATAS D+ Sbjct: 90 RSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVT 149 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL-LTTDQKSEIRVYSASQWDCPLGL 326 ++WD+ L V F P L T IR+Y Sbjct: 150 RLWDISN--AYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIY 207 Query: 327 IPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQL 386 + + +++ + ++ G NFK + + + + C Sbjct: 208 SLNHDQPVENVIAVSPTQ-----IVSCGG---NNFKVWDLTSNKKLYERGNFNKAVTCLD 259 Query: 387 YDPESSGISSLNEFN-PMGDTL-ASAMGYHILIW 418 Y + F+ PM L AS++ H+ ++ Sbjct: 260 Y---------VENFDSPMQSALIASSLDGHVKVF 284 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 46/341 (13%), Positives = 101/341 (29%), Gaps = 49/341 (14%) Query: 18 RPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTL---- 73 RPR S++PL P + W Q++ S+ Sbjct: 5 RPRIITSKAPL--------------LPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQ 50 Query: 74 --HQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGS 131 H + ++ + + + T ++ + +A F + G Sbjct: 51 HPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRS----------DGKLLCAGD 100 Query: 132 KGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL 191 G + +++ + + + KF+ + +S + TRL D Sbjct: 101 ATGLVSVYDSYNP-RTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYE 159 Query: 192 RVFASSDTINIWFCSLDVSASSR-MVVTGDNVGNVILLNM--DGKELWNLRMHKKKV-TH 247 + + +L ++ +V TG G + L + G H + V Sbjct: 160 PQLELTGATDY-VRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENV 218 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF-----SPDGAR 302 +A++P + + + K+WDL + V + SP + Sbjct: 219 IAVSP---TQIVSCGGNN-FKVWDLTSNK---KLYERGNFNKAVTCLDYVENFDSPMQSA 271 Query: 303 LLTTDQKSEIRVYS-ASQWDCPLGLIPHPHRHFQHLTPIKA 342 L+ + ++V+ + G ++P A Sbjct: 272 LIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTA 312 >6J6H-n nrPDB Length = 455 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 76/232 (32%), Gaps = 16/232 (6%) Query: 87 QQGLQQSFLHTLDSYRI----LQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFG 142 Q L SF ++ + ++ + + PT+P VG I+ ++ Sbjct: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 Query: 143 I-KDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTIN 201 + +++ SI LK+ P + +F +SS + T R+ + + N+ S DT Sbjct: 279 VSENQGLVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWENQINVPIKQIS-DTAQ 336 Query: 202 IWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN----LRMHK--KKVTHVALNPCCD 255 L+V S + ++ K + + H +A + Sbjct: 337 HSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 Query: 256 WFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 + + + WD R + +P P+ + P + Sbjct: 397 YIC-SGDSKSRLFTWDWNTSRLLNNI--KIPGNKPITQVDWHPQETSKVICS 445 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 42/261 (16%), Positives = 82/261 (31%), Gaps = 64/261 (24%) Query: 211 ASSRMVVTGDNVGNVILLNM--DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 268 + ++++G N + + + D + L + + H K + + C FL ++S D++VK Sbjct: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFL-SSSFDRSVK 231 Query: 269 IWD-----------LRQVRGKASFLYSLPHR----------------------------- 288 IWD L + PH Sbjct: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDH 291 Query: 289 --HPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHP 346 + A + PDG++ +++ + +R++ + QH P HP Sbjct: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA----QHSMPFLNV-HP 346 Query: 347 RYNLIVVGRYPDP--NFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG 404 N + +F Y+ +F G+S S+G F+ G Sbjct: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS-----------SAGYGISLAFSGDG 395 Query: 405 DTLASA-MGYHILIWSQEEAR 424 + S + W +R Sbjct: 396 RYICSGDSKSRLFTWDWNTSR 416 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 63/189 (33%), Gaps = 18/189 (9%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVN 292 K + N H + T + P + + D T+KIWD + + H P+ Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY-ECLRDFQ-GHNKPIK 210 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIV 352 A F+ D L++ ++++ L + P +P ++ Sbjct: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT----NPHEFIVG 266 Query: 353 VGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMG 412 + Y+ R + + + Q YD S I +L F ++S+ Sbjct: 267 LSNS------KILHYDDRV------SENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 Query: 413 YHILIWSQE 421 + IW + Sbjct: 315 KTVRIWENQ 323 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 62/178 (34%), Gaps = 8/178 (4%) Query: 99 DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS 158 ++ ++Q +L + P S S+ + +W I + P A S Sbjct: 281 ENQGLVQTYDHHLSSILALKYFPD-GSKFISSSEDKTVRIWENQI-NVPIKQISDTAQHS 338 Query: 159 ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR---VFASSDTINIWFCSLDVSASSRM 215 + L +P + N F A SM+ K R + + SL S R Sbjct: 339 MPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 Query: 216 VVTGDNVGNVILLN-MDGKELWNLR-MHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 + +GD+ + + + L N++ K +T V +P + + + + D Sbjct: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 >5M89-A nrPDB Length = 329 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 76/216 (35%), Gaps = 16/216 (7%) Query: 114 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 173 T+ W + V +G+ G + +++ G + G +TGL +P Sbjct: 95 VTATEWT---GTKVVIGTAKGWVKVYDAGRES----ATFQTHAGPVTGLAVHPGGR-ILA 146 Query: 174 ASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK 233 + ++ + D + + + + + G G++++ + Sbjct: 147 SVGVDKSFVFYDLETGERVARGYA---DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTL 203 Query: 234 ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNA 293 E + +A + WF AT +V I+DLR+ G A+ + L V + Sbjct: 204 EQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRK-SGAAAAVKELQ-TGEVLS 261 Query: 294 ACFSPDGARLLTTDQKS-EIRVYS--ASQWDCPLGL 326 + G L T +++Y+ W P+ L Sbjct: 262 ISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRL 297 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 37/139 (26%), Gaps = 15/139 (10%) Query: 217 VTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 G G + + ++ ++ + VT + + VK++D + Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATEW---TGTKVVIGTAKGWVKVYDAGRES 123 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 H PV P G L + Y + R + Sbjct: 124 ATFQT-----HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVA-------RGYAD 171 Query: 337 LTPIKAAWHPRYNLIVVGR 355 A+HP NL G Sbjct: 172 AALTTCAFHPDGNLFAAGT 190 >4G56-B nrPDB Length = 357 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 36/194 (18%), Positives = 64/194 (32%), Gaps = 9/194 (4%) Query: 122 THPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTT 181 + + G K + +W+ + K + + P F + +G Sbjct: 149 SDGTQAVSGGKDFSVKVWD--LSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRI 206 Query: 182 RLQDFKGNILRVFASSDTINIWFCSLDVSA-SSRMVVTGDNVGNVILLNMDG-KELWNLR 239 L D + + S+ GD GNV L+N+ Sbjct: 207 LLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSA 266 Query: 240 MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP- 298 +H + +T +A + FLA+ S D TV + D + L HR V +SP Sbjct: 267 VHSQNITGLAYSYHSSPFLASISEDCTVAVLDA----DFSEVFRDLSHRDFVTGVAWSPL 322 Query: 299 DGARLLTTDQKSEI 312 D ++ T ++ Sbjct: 323 DHSKFTTVGWDHKV 336 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 33/170 (19%), Positives = 58/170 (34%), Gaps = 1/170 (0%) Query: 98 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 157 L +L+ +A P + + G I+LW+ T I + Sbjct: 168 LSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDT 227 Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 T + ++P + F G L + K ++ + NI + SS + Sbjct: 228 IPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYH-SSPFLA 286 Query: 218 TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 + V +L+ D E++ H+ VT VA +P T D V Sbjct: 287 SISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 29/200 (14%), Positives = 65/200 (32%), Gaps = 11/200 (5%) Query: 152 GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTI--NIWFCSLDV 209 G+ +T + + + S G L + + + +L V Sbjct: 90 GVQTEAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSV 147 Query: 210 SASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 268 + V+G +V + ++ K L + H +V VA P D + D + Sbjct: 148 FSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRIL 207 Query: 269 IWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQK-SEIRVYSASQWDCPLGLI 327 +WD R+ + A+ + + + P+ + + + + D Sbjct: 208 LWDTRKPK-PATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSA 266 Query: 328 PHPHRHFQHLTPIKAAWHPR 347 H Q++T + ++H Sbjct: 267 VHS----QNITGLAYSYHSS 282 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 59/230 (25%), Gaps = 32/230 (13%) Query: 182 RLQDFKGNILRVFASSDTINIWFCSLD-------------VSASSRMVVTGDNVGNVI-L 227 R G + VF + VS +V + + + Sbjct: 66 RTW---GGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILVASDSGAVELWEI 122 Query: 228 LNMDGKELWNLRM--HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 285 L + + H V +++ + D +VK+WDL Q KA Sbjct: 123 LEKESLLVNKFAKYEHDDIVKTLSVFSDGT-QAVSGGKDFSVKVWDLSQ---KAVLKSYN 178 Query: 286 PHRHPVNAACFSPDGARL-LTTDQKSEIRVYSASQWDCPLGLIPHPHRHF--QHLTPIKA 342 H VN P + L+ + I ++ P F P Sbjct: 179 AHSSEVNCVAACPGKDTIFLSCGEDGRILLWD------TRKPKPATRIDFCASDTIPTSV 232 Query: 343 AWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESS 392 WHP + N + +S + Y SS Sbjct: 233 TWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSS 282 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 21/163 (12%), Positives = 49/163 (30%), Gaps = 21/163 (12%) Query: 268 KIWDLRQVRG---KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPL 324 IW + G ++ + V + + +L + ++ + + Sbjct: 71 SIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG-ILVASDSGAVELWEILEKE--- 126 Query: 325 GLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMC 384 L+ + ++H +K V D + K + + ++ +S ++ C Sbjct: 127 SLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNC 186 Query: 385 QLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEARTRK 427 P I L+ IL+W + R K Sbjct: 187 VAACPGKDTIF-----------LSCGEDGRILLW---DTRKPK 215 >3ACP-A nrPDB Length = 417 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 87/247 (35%), Gaps = 34/247 (13%) Query: 95 LHTLDSYRILQKAA--PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG 152 + LDS LQ+ T L + P + S+ + +W+ +KD Sbjct: 118 IKVLDSNFNLQREIDQAHVSEITKLKFFP-SGEALISSSQDMQLKIWS--VKDGSNPRTL 174 Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGN-ILRVFASSDTINIWFCS----- 206 IG ++T + N ++S++GT RL + + F + + S Sbjct: 175 IGHRATVTDIAIIDRGRNVL-SASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFV 233 Query: 207 ----------------LDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKV---TH 247 L+ + V+ G G + + N+ KE +++ K Sbjct: 234 GTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKE-QTIQLPSKFTCSCNS 292 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 + ++ ++ + + WDLR + + P+N F+ GA +++ Sbjct: 293 LTVDGNNANYIYAGYENGMLAQWDLRSPEC-PVGEFLINEGTPINNVYFAA-GALFVSSG 350 Query: 308 QKSEIRV 314 + I++ Sbjct: 351 FDTSIKL 357 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 37/119 (31%), Gaps = 10/119 (8%) Query: 261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 320 + + +K+ D H + F P G L+++ Q +++++S Sbjct: 112 GTTEGDIKVLDSN---FNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDG 168 Query: 321 DCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNS 379 P LI H +T I V+ D + TI F+ Sbjct: 169 SNPRTLIGHRAT----VTDIAII---DRGRNVLSASLDGTIRLWECGTGTTIHTFNRKE 220 Score = 31.4 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 13/114 (11%), Positives = 37/114 (32%), Gaps = 21/114 (18%) Query: 306 TDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI-KAAWHPRYNLIVVGRYPDPNFKSC 364 + +I+V ++ L + H++ I K + P ++ D K Sbjct: 112 GTTEGDIKVLDSN-----FNLQREIDQA--HVSEITKLKFFPSGEALISSS-QDMQLKIW 163 Query: 365 TPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIW 418 + + G + ++ + + + L++++ I +W Sbjct: 164 SVKDGSNPRTLIG------------HRATVTDIAIIDRGRNVLSASLDGTIRLW 205 >5N4A-A nrPDB Length = 771 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 41/291 (14%), Positives = 84/291 (28%), Gaps = 24/291 (8%) Query: 107 AAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG-----AGGSITG 161 A ++ W+ + + S I WN + + ++ Sbjct: 10 ANVHSELTAAVGWNVW--NELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSS 67 Query: 162 LKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDN 221 K T+ F + +G+ ++ G + SL S + T Sbjct: 68 KKTQAGGTDVFAVACTDGSVKILSRTGRVE-KSIEGHK--GACISLRWSYDGTALATAGE 124 Query: 222 VGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF 281 G+V + + +G L V + CD + +K + A Sbjct: 125 DGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIK-----SLSSNAKQ 179 Query: 282 LYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 H V +SP ++T + + +V+ + L+ Sbjct: 180 NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFG-----RLLF--QSGLFDYPVTS 232 Query: 342 AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESS 392 AW P L VG + + C + ++G +M + +S+ Sbjct: 233 VAWAPSGELFAVGGF--NTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADST 281 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 28/207 (13%), Positives = 69/207 (33%), Gaps = 21/207 (10%) Query: 102 RILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITG 161 R+ + SL W + +A + G + +W+ ++ A + Sbjct: 95 RVEKSIEGHKGACISLRWS-YDGTALATAGEDGSVKIWS---RNGMLRSTLAQADSPVYS 150 Query: 162 LKFNPL-NTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGD 220 + + + + S ++ N + + + +D S + +++TG Sbjct: 151 IVWAYDCDQLCYCTGS---NVVIKSLSSNAKQNAWKAH--DGVVLKVDWSPINHLIITGG 205 Query: 221 NVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 + + G+ L+ + VT VA P + F ++ Q+ + Sbjct: 206 EDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFAVGG--------FNTLQLCDRMG 257 Query: 281 FLYSLPHRHP---VNAACFSPDGARLL 304 + YS H + + ++ D +L Sbjct: 258 WAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 34/218 (15%), Positives = 69/218 (31%), Gaps = 33/218 (15%) Query: 181 TRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG---KELWN 237 +++ N+ ++ N+W S + + NM G +++ Sbjct: 3 LKVKQSSANVHSELTAAVGWNVWNELFTCS----------DDQTIHKWNMLGEPEQKVST 52 Query: 238 LRM-----HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVN 292 L H V+ A A D +VKI R R + S H+ Sbjct: 53 LDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILS-RTGRVEKSIE---GHKGACI 108 Query: 293 AACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI-KAAWHPRYNLI 351 + +S DG L T + ++++S L Q +P+ W + + Sbjct: 109 SLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTLA-------QADSPVYSIVWAYDCDQL 160 Query: 352 VVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 389 + KS + + + + G ++ + P Sbjct: 161 CYCTGSNVVIKSLSSNAKQN--AWKAHDGVVLKVDWSP 196 >3JZG-A nrPDB Length = 402 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 27/181 (14%), Positives = 67/181 (37%), Gaps = 25/181 (13%) Query: 153 IGAGGSITGLKFNPL--------------NTNQFYASSMEGTTRLQDFKGNILRVFASSD 198 + G++FN N Y +G RL L+ + +D Sbjct: 51 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRL-------LQSYVDAD 103 Query: 199 TINIWFCS---LDVSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCC 254 ++ D + S ++ + G + ++N + + + + H + + +P Sbjct: 104 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 163 Query: 255 DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 L + S D +++W+++ A F HR V +A + G ++++ +++ Sbjct: 164 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 223 Query: 315 Y 315 + Sbjct: 224 W 224 Score = 61.4 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 40/285 (14%), Positives = 83/285 (29%), Gaps = 55/285 (19%) Query: 78 LGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIM 137 L A + + + + + Y A L +HP P+ + SK + Sbjct: 124 LAVAGSRGIIRIINPITMQCIKHYVGHGNA------INELKFHPRDPNLLLSVSKDHALR 177 Query: 138 LWNFGIKDKPTFIKG---IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVF 194 LWN I+ G + ++ L + + M+ + +L + Sbjct: 178 LWN--IQTDTLVAIFGGVEGHRDEVLSADYDLLGE-KIMSCGMDHSLKLWRINSKRMMNA 234 Query: 195 AS------SDTINIWFCSL-----DVSAS-------------SRMVVTGDNVGNVILLNM 230 + N F S D S ++++ ++ Sbjct: 235 IKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP 294 Query: 231 DGKE--LWNLRMHKKKVTHVA---LNPCCDWF-----------LATASVDQTVKIWDLRQ 274 E + ++ + VT + + C W+ LA + + +WDL Sbjct: 295 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 354 Query: 275 VRGKASFLYSLPH---RHPVNAACFSPDGARLLTTDQKSEIRVYS 316 + +L H + FS D + L+ + I + Sbjct: 355 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 28/204 (13%), Positives = 65/204 (31%), Gaps = 29/204 (14%) Query: 233 KELWNLR-MHKKKVTHVALNPC---CDWFLATASVDQTVKIWDLRQVRGKASFLYSL--- 285 K + +L+ H + + V N D + V +++ +G+ L S Sbjct: 44 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS-QGEIRLLQSYVDA 102 Query: 286 PHRHPVNAACFSPDGA----RLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 ++ D L + IR+ + C + H + + Sbjct: 103 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINE------ 156 Query: 342 AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFN 401 +HPR +++ D + + +F G + + S + ++ Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG---------VEGHRDEVLSAD-YD 206 Query: 402 PMGDTLASA-MGYHILIWSQEEAR 424 +G+ + S M + + +W R Sbjct: 207 LLGEKIMSCGMDHSLKLWRINSKR 230 >5WYJ-BE nrPDB Length = 939 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 57/361 (15%), Positives = 106/361 (29%), Gaps = 44/361 (12%) Query: 59 GPQILPP-----CRSIVRTLHQHKLGRASWP-SVQQGLQQSFLHTLDSYRILQKAAPFDR 112 G PP S + R+ W S+++ Q + S R+ +K Sbjct: 347 GGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEM----SQRLHKKQDG--G 400 Query: 113 RATSLAWHPTHPSTVAVGSKGGDI----------------MLWNFGIKDKPTFIKGIGAG 156 R P VA+ + I W+ K + Sbjct: 401 RVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDD 460 Query: 157 GSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMV 216 G + + + F SS G+ + + + ILR + SL +R + Sbjct: 461 GFVKSVAMSQCGNFGFIGSS-NGSITIYNMQSGILRKKYKLHKRAVTGISL--DGMNRKM 517 Query: 217 VTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR 276 V+ G V + + L +T + + A A D ++ + D R Sbjct: 518 VSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYH-RSSDLFALALDDLSIVVIDAVTQR 576 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 H + + A FSP+G +++ S IR + C G+I Sbjct: 577 VVRQL---WGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGII-------VD 626 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTP-YELRTIDVFDGNSGKMMCQLYDPESSGIS 395 + P +L+ T + +T+ + + P +S Sbjct: 627 NVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMAL-PSTSVRG 685 Query: 396 S 396 + Sbjct: 686 N 686 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 42/346 (12%), Positives = 113/346 (32%), Gaps = 41/346 (11%) Query: 56 GLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRAT 115 + G +I+ + + L++ + S L + + +++ + F + T Sbjct: 161 EIQGGEIVS-LQHLATYLNKLTVVTKS---------NVLLFNVRTGKLVFTSNEFPDQIT 210 Query: 116 SLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYAS 175 + P +A+G+ G+++++N I+ L F ++ Sbjct: 211 TAEPAPVL-DIIALGTVTGEVIMFNMR--KGKRIRTIKIPQSRISSLSFRTDGSSHLSVG 267 Query: 176 SMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVVT---GDNVGNVILLNMD 231 + G D + + + V + + + + + ++ GDN + + Sbjct: 268 TSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPS 327 Query: 232 GKE------------LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR---QVR 276 + L + H + +++A F+ +AS D+++ + LR Q + Sbjct: 328 LSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQ 387 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQH 336 + L+ V + ++ ++ R+ +W+ + H F Sbjct: 388 EMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIEN-ARI---GEWENI--ITAHKDEKFAR 441 Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 ++ + R D KS + ++G + Sbjct: 442 TWDMR---NKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSI 484 >5A9Q-2 nrPDB Length = 326 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 52/152 (34%), Gaps = 13/152 (8%) Query: 186 FKGNILRVFASSDTIN--IWFCSLDVSASSRMV--VTGDNVGNVILLN---MDGKELWNL 238 + LR F ++ W + + ++ T + L D E L Sbjct: 61 IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL 120 Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP 298 H + + +P +A+ S D T +IW+L V+ L+ P + C+ P Sbjct: 121 EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH-----SPGMSVCWHP 175 Query: 299 DGAR-LLTTDQKSEIRVYSASQWDCPLGLIPH 329 + L+ ++ IR Y L L Sbjct: 176 EETFKLMVAEKNGTIRFYDLLAQQAILSLESE 207 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 65/203 (32%), Gaps = 28/203 (13%) Query: 85 SVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTH-------PSTVAVGSKGGDIM 137 + +G+Q L T R +AW P + I Sbjct: 56 ADVEGIQYKTLRTF----------HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIR 105 Query: 138 LWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR--VFA 195 L+ ++DK + G I GL F+P + + S + T R+ + +G V Sbjct: 106 LFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH 165 Query: 196 SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE-LWNLRMHKKKVTHVALNPCC 254 S W ++ + G + ++ ++ + +L + + Sbjct: 166 SPGMSVCWHPEETFK-----LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKN 220 Query: 255 DWFL-ATASVDQTVKIWDLRQVR 276 + + A A D IWD+ + Sbjct: 221 TFKVGAVAGNDWL--IWDITRSS 241 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 27/192 (14%), Positives = 60/192 (31%), Gaps = 27/192 (14%) Query: 212 SSRMVVTGDNVGNVI--------LLNMDGKELWNLRM--HKKKVTHVALNPCCDW----- 256 S ++ G N VI +++G + LR H +V +A +P Sbjct: 32 SGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPP 91 Query: 257 --FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIR 313 T++ D ++++ ++ K + H +N F P +G + + R Sbjct: 92 VIKFCTSAADMKIRLF-TSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCR 150 Query: 314 VYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTID 373 +++ H + WHP ++ + + + I Sbjct: 151 IWNLEGVQTAH--------FVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAIL 202 Query: 374 VFDGNSGKMMCQ 385 + +M Sbjct: 203 SLESEQVPLMSA 214 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 23/233 (9%), Positives = 57/233 (24%), Gaps = 22/233 (9%) Query: 94 FLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI 153 F L + L + P +A S +WN + + Sbjct: 107 FTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL---EGVQTAHFV 163 Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 + ++P T + + GT R D + S+ + + + + Sbjct: 164 LHS-PGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTF 222 Query: 214 RMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 ++ N + + +H + + + AT + Sbjct: 223 KVGAVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKM------ 276 Query: 274 QVRGKASFLYSLPHRHPV--------NAACFSPDGARLLTTDQKSEIRVYSAS 318 ++ L H P+ + + L ++ + Sbjct: 277 ---ASQFQIHHLGHPQPILMGSVAVGSGLSWHRT-LPLCVIGGDHKLLFWVTE 325 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 51/161 (31%), Gaps = 30/161 (18%) Query: 283 YSLPHRHPVNAACFSP----DGARLLTTDQKSEIRVYS---ASQWDCPLGLIPHPHRHFQ 335 Y++ V+ F+P D L+ + + + + + G+ R F Sbjct: 11 YTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFH 70 Query: 336 HLTPIK-AAWHPRYNL-------IVVGRYPDPNFKSC--TPYELRTIDVFDGNSGKMMCQ 385 H + AW P L D + + V +G++ + Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGL 130 Query: 386 LYDPESSGISSLNEFNPMGDTLASAMGYHI-LIWSQEEART 425 ++DP+ G +AS H IW+ E +T Sbjct: 131 VFDPKE------------GQEIASVSDDHTCRIWNLEGVQT 159 >5A9Q-7 nrPDB Length = 360 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 46/327 (14%), Positives = 95/327 (29%), Gaps = 51/327 (15%) Query: 123 HPSTVAVGSKGGDIMLWNFGIK-DKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEGT 180 H +A S + +W+ D GS+ + + +P + S + T Sbjct: 23 HGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRT 82 Query: 181 TRLQD--FKGNILRVFASSD--------TINIWFCSLDVSAS--SRMVVTGDNVGNVILL 228 + + + ++ S + + M+ T G V + Sbjct: 83 AAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIY 142 Query: 229 ------NMDGKELWNLRMHKKKVTHVALNPCCDW----FLATASVDQT------VKIWDL 272 N+ L + K + ++ NP +A S D + V+I++ Sbjct: 143 EAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202 Query: 273 R-QVRGKASFLYSLPHRHPVNAACFSPD---GARLLTTDQKSEIRVYSASQWDCPLGLIP 328 R A + PV+ F+P+ +L K ++R+++ L Sbjct: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATK-DVRIFTLKPVRKELTSSG 261 Query: 329 HPHRHFQHLT-----PIKAAWHPRYNL---IVVGRYPDPNFKSCTPY---ELRTIDVFDG 377 P + H+ W +N+ ++ D + + + G Sbjct: 262 GPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKG 321 Query: 378 NSGKMMCQLYDPE-----SSGISSLNE 399 N + S I SL Sbjct: 322 NGSPVNGSSQQGTSNPSLGSTIPSLQN 348 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 43/269 (15%), Positives = 81/269 (30%), Gaps = 51/269 (18%) Query: 110 FDRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGA----------GGS 158 + W HP +A S +W + + ++G S Sbjct: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115 Query: 159 ITGLKFNPLNTN-QFYASSMEGTTRLQ---DFKGNILRVFASSDTINIWFCSLDVSASS- 213 +T +KF P + S +G R+ D + + + + SS Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSS 175 Query: 214 ----RMVVTGDNVG------NVILL-----NMDGKELWNLRMHKKKVTHVALNPC---CD 255 M+ G + V + + L V +A P Sbjct: 176 RAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSF 235 Query: 256 WFLATASVDQTVKIWDLRQVRGKAS--------FLYSLP----HRHPVNAACFSPDGARL 303 LA A+ D V+I+ L+ VR + + ++ + H V ++ G L Sbjct: 236 HILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVL 293 Query: 304 LTTDQKSEIRVYSA---SQWDCPLGLIPH 329 ++ +R++ A W C L + Sbjct: 294 ASSGDDGCVRLWKANYMDNWKCTGILKGN 322 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 47/143 (32%), Gaps = 14/143 (9%) Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYS---ASQWDCPLGLIPHPHRHFQHLTPIKAA 343 H+ ++ F G R+ T ++V+ + W C H ++ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR------VT 64 Query: 344 W-HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNP 402 W HP + ++ D + D G S + + ++ + +F P Sbjct: 65 WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDV-KFAP 123 Query: 403 --MGDTLASAMGYHI-LIWSQEE 422 MG LA+ I I+ + Sbjct: 124 KHMGLMLATCSADGIVRIYEAPD 146 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 52/181 (28%), Gaps = 20/181 (11%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACF-SP 298 HK + V+ + +AT S DQ+VK+WD + G S H V + P Sbjct: 11 HKDLIHDVSFDFHGRR-MATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHP 68 Query: 299 D-GARLLTTDQKSEIRVYSASQWDCPLGLIPHPH-----RHFQHLTPIKAAWHPRY--NL 350 + G L + V+ + L H T + L Sbjct: 69 EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGL 128 Query: 351 IVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA 410 ++ D + ++ + ++ S +NP S Sbjct: 129 MLATCSADGIVRIYEAPDVMNLSQ--------WSLQHEISCKLSCSCISWNPSSSRAHSP 180 Query: 411 M 411 M Sbjct: 181 M 181 >5MWJ-A nrPDB Length = 337 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 93/283 (32%), Gaps = 19/283 (6%) Query: 122 THPSTVAVGSKGGDIMLWNF---GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSME 178 ++P+ G + +W+ G K + + + I K P Sbjct: 60 SNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCT-LIVGGEA 118 Query: 179 GTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL-WN 237 T + D R+ A + +L +S S++ + + GN+ + ++ + L Sbjct: 119 STLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQ 178 Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 297 + H + + ++ L T +D TV+ WDLR+ R ++ + + + Sbjct: 179 FQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT----SQIFSLGYC 233 Query: 298 PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYP 357 P G L + S + + P ++ H + + + V Sbjct: 234 PTGEWLAVGMESSNV--------EVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK 285 Query: 358 DPNFKSC-TPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 399 D + TPY + +S D + S ++ Sbjct: 286 DNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDK 328 Score = 61.0 bits (146), Expect = 8e-10, Method: Composition-based stats. Identities = 43/217 (19%), Positives = 61/217 (28%), Gaps = 36/217 (16%) Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDG-------KELWNLRMHKKKVTHVALNPCCDW 256 C++ +S +R V TG G V + ++ +L L + L P Sbjct: 54 VCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLN-RDNYIRSCKLLPDGCT 111 Query: 257 FLATASVDQTVKIWDLR--QVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 + T+ IWDL R KA S P A SPD + I V Sbjct: 112 LIV-GGEASTLSIWDLAAPTPRIKAELTSSAPA---CYALAISPDSKVCFSCCSDGNIAV 167 Query: 315 YSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDV 374 + H + D +S E R + Sbjct: 168 WDLHNQTLVRQFQGHTD-------GASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 375 FDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAM 411 D S I SL + P G+ LA M Sbjct: 221 HDFTSQ-------------IFSLG-YCPTGEWLAVGM 243 >6CB1-s nrPDB Length = 569 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 70/218 (32%), Gaps = 17/218 (7%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 + L+WH V V G+ + + T + G I KF+P Sbjct: 357 KTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 416 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231 F S R+ D IL W +D+ ++ V+ ++D Sbjct: 417 FVCSQR--YVRIYDLSQQILVKKLLPGA--RWLSKIDIHPRGDNLIASSFDKRVLWHDLD 472 Query: 232 --GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP--- 286 LR H+K V V + ++A+ D T+ ++ +P Sbjct: 473 LASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK 531 Query: 287 ---HRHP----VNAACFSPDGARLLTTDQKSEIRVYSA 317 H+ V A + P A L + + R+++ Sbjct: 532 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 569 Score = 54.5 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 22/79 (27%), Gaps = 1/79 (1%) Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 DLR + S +Y H+ V P G L T +RV+ Sbjct: 183 DLRPFPIRCSTIY-AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLID 241 Query: 331 HRHFQHLTPIKAAWHPRYN 349 W+P N Sbjct: 242 DEENPDYHIECIEWNPDAN 260 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP-- 290 + HK KV ++++P W LAT S D TV++W++ R +P Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 248 Query: 291 -VNAACFSPDGA 301 + ++PD Sbjct: 249 HIECIEWNPDAN 260 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 43/302 (14%), Positives = 93/302 (30%), Gaps = 47/302 (15%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL----RVFASSDTINIW 203 G G + L +P S +GT R+ + + + + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 204 FCSLDVSASSR----MVVTGDNVGNVI--LLN-----------MDGKELWNLRMHKKKVT 246 ++ + + V G+N+ ++ + DG KK Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 247 HVALNPCCDW----FLATASVDQTVKIWDL-RQVRGKASFLYSLPHRHPVNAACFSPDGA 301 V N D A +V + V W+ Q + + ++ + V + G Sbjct: 310 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 369 Query: 302 RLLTTDQK-SEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360 +T V L P + + + + A +HP + V Sbjct: 370 YFVTVQPDSGNTSVLIH---QVSKHLTQSPFKKSKGII-MDAKFHPFKPQLFVCS----- 420 Query: 361 FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ 420 R + ++D + ++ +L P + +S ++ +P GD L ++ ++W Sbjct: 421 --------QRYVRIYDLSQQILVKKLL-PGARWLSKID-IHPRGDNLIASSFDKRVLWHD 470 Query: 421 EE 422 + Sbjct: 471 LD 472 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 46/322 (14%), Positives = 93/322 (28%), Gaps = 37/322 (11%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNF----GIKDKPTFI 150 L A + +L+ P +A GS G + +W + Sbjct: 184 LRPFPIRCSTIYAGH-KGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLID 241 Query: 151 KGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL-------QDFKGNILRVFASSDTINIW 203 I +++NP N A ++ L D + N + + Sbjct: 242 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 301 Query: 204 ----FCSLDVSASSRMVVTGDN-------VGNVILLNMDGKE-----LWNLRMHKKKVTH 247 +L+V+ + G+N V N ++ + KK V Sbjct: 302 GTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKK 361 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 ++ + D+F+ + + QV + + + A F P +L Sbjct: 362 LSWHRKGDYFVTVQPDSGNTSVL-IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 420 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 Q+ +R+Y SQ L+P + L+ I HPR + ++ + Sbjct: 421 QR-YVRIYDLSQQILVKKLLP----GARWLSKIDI--HPRGDNLIASSFDKRVLWHDLDL 473 Query: 368 ELRTIDVFDGNSGKMMCQLYDP 389 + + + Sbjct: 474 ASTPYKTLRYHEKAVRSVNFHK 495 >6F1U-h nrPDB Length = 612 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 65/205 (31%), Gaps = 11/205 (5%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGS----ITGLKFNPLNTNQFYASSMEGTT- 181 + S G I W+ + P + S +T + F + N F S EG+ Sbjct: 372 LISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVY 431 Query: 182 ---RLQDFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLNMDGKE-L 235 R G I C V A S + VT V L + + L Sbjct: 432 TACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPL 491 Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 ++ + V V +P A + +W+L + S+ +N Sbjct: 492 YSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVR 551 Query: 296 FSPDGARLLTTDQKSEIRVYSASQW 320 ++ G + D + +I +Y + Sbjct: 552 WTHSGREIAVGDSEGQIVIYDVGEQ 576 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 73/235 (31%), Gaps = 24/235 (10%) Query: 105 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK----GIGAGGSIT 160 + S + HP+ V G+ G I+LW+ + + + Sbjct: 300 EYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVY 359 Query: 161 GLK-FNPLNTNQFYASSMEGTTRLQDF------KGNILRVFASSDTINIWFCSLDVSASS 213 + N + + S +G + ++ V S + + S V Sbjct: 360 CVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVG-DV 418 Query: 214 RMVVTGDNVGNVILLNMDGKELWN---LRMHKKKVTHVALNP-----CCDWFLATASVDQ 265 V G G+V G + H+ +T + + T+S D Sbjct: 419 NNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDW 478 Query: 266 TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTT-DQKSEIRVYSASQ 319 TVK+W + + SF + + V +SP L D + +++ + Sbjct: 479 TVKLWSTKNNKPLYSFEDNAGY---VYDVMWSPTHPALFACVDGMGRLDLWNLNN 530 >2P9P-C nrPDB Length = 372 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 76/234 (32%), Gaps = 25/234 (10%) Query: 118 AWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSM 177 AW+ + +A+ ++ ++ + G +TG+ + P ++N+ Sbjct: 15 AWN-KDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGT 72 Query: 178 EGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN 237 + + KG + IN + + + + G + + + + W Sbjct: 73 DRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWW 132 Query: 238 LRMHKKK-----VTHVALNPCCDWFLATASVDQTVKI----------------WDLRQVR 276 + H KK V + +P LA S D +I W + Sbjct: 133 VCKHIKKPIRSTVLSLDWHPN-SVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPF 191 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 G+ F S V+ CFS +G+R+ S + + A + L Sbjct: 192 GELMFESSSS-CGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASET 244 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 57/178 (32%), Gaps = 8/178 (4%) Query: 158 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 217 I+ +N + Q + + GN N +D + S +V Sbjct: 10 PISCHAWNK-DRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 218 TGDNVGNVILLNMDGKE----LWNLRMHKKKVTHVALNPCCD-WFLATASVDQTVKIWDL 272 T N + + G+ L LR+++ V P + + + S ++ ++ Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAA-RCVRWAPNEKKFAVGSGSRVISICYFEQ 127 Query: 273 RQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 + P R V + + P+ L + R++SA + P P Sbjct: 128 ENDWWVCKHIKK-PIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTP 184 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 66/181 (36%), Gaps = 25/181 (13%) Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNAACFSPDGAR 302 ++ A N +A + V I++ + K ++ L H V ++PD R Sbjct: 10 PISCHAWNKD-RTQIAICPNNHEVHIYE--KSGNKWVQVHELKEHNGQVTGVDWAPDSNR 66 Query: 303 LLTTDQKSEIRVYSAS--QWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360 ++T V++ W L I +R + + W P VG Sbjct: 67 IVTCGTDRNAYVWTLKGRTWKPTLV-ILRINRAARCVR-----WAPNEKKFAVGS----- 115 Query: 361 FKSCTPYELRTIDVFDGNSGKMMCQ-LYDPESSGISSLNEFNPMGDTLASAM-GYHILIW 418 + +I F+ + +C+ + P S + SL+ ++P LA+ + I+ Sbjct: 116 -----GSRVISICYFEQENDWWVCKHIKKPIRSTVLSLD-WHPNSVLLAAGSCDFKCRIF 169 Query: 419 S 419 S Sbjct: 170 S 170 Score = 29.4 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 67/228 (29%), Gaps = 64/228 (28%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKD----------------KPTFIKG 152 P SL WHP +A GS +++ IK+ + Sbjct: 140 PIRSTVLSLDWHPNSV-LLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFES 198 Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 + G + G+ F+ + + S + T L D + +S+T+ ++ Sbjct: 199 SSSCGWVHGVCFSANGSRVAWV-SHDSTVCLADADKKMAVATLASETL--PLLAVTFITE 255 Query: 213 SRMVVTG-DNVGNVILLNMDGKELWN---------------------------------- 237 S +V G D + + +L Sbjct: 256 SSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSA 315 Query: 238 -----LRM-HKKKVTHVALNPCCDWFLA---TASVDQTVKIWDLRQVR 276 L HK V+ +++ + T +D + IWD+R + Sbjct: 316 AAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLE 363 >6C0F-s nrPDB Length = 807 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 70/218 (32%), Gaps = 17/218 (7%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 + L+WH V V G+ + + T + G I KF+P Sbjct: 595 KTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231 F S R+ D IL W +D+ ++ V+ ++D Sbjct: 655 FVCSQR--YVRIYDLSQQILVKKLLPGA--RWLSKIDIHPRGDNLIASSFDKRVLWHDLD 710 Query: 232 --GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP--- 286 LR H+K V V + ++A+ D T+ ++ +P Sbjct: 711 LASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK 769 Query: 287 ---HRHP----VNAACFSPDGARLLTTDQKSEIRVYSA 317 H+ V A + P A L + + R+++ Sbjct: 770 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 54.5 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 22/79 (27%), Gaps = 1/79 (1%) Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 DLR + S +Y H+ V P G L T +RV+ Sbjct: 421 DLRPFPIRCSTIY-AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLID 479 Query: 331 HRHFQHLTPIKAAWHPRYN 349 W+P N Sbjct: 480 DEENPDYHIECIEWNPDAN 498 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP-- 290 + HK KV ++++P W LAT S D TV++W++ R +P Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 486 Query: 291 -VNAACFSPDGA 301 + ++PD Sbjct: 487 HIECIEWNPDAN 498 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 43/302 (14%), Positives = 93/302 (30%), Gaps = 47/302 (15%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL----RVFASSDTINIW 203 G G + L +P S +GT R+ + + + + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 204 FCSLDVSASSR----MVVTGDNVGNVI--LLN-----------MDGKELWNLRMHKKKVT 246 ++ + + V G+N+ ++ + DG KK Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 247 HVALNPCCDW----FLATASVDQTVKIWDL-RQVRGKASFLYSLPHRHPVNAACFSPDGA 301 V N D A +V + V W+ Q + + ++ + V + G Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 302 RLLTTDQK-SEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360 +T V L P + + + + A +HP + V Sbjct: 608 YFVTVQPDSGNTSVLIH---QVSKHLTQSPFKKSKGII-MDAKFHPFKPQLFVCS----- 658 Query: 361 FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ 420 R + ++D + ++ +L P + +S ++ +P GD L ++ ++W Sbjct: 659 --------QRYVRIYDLSQQILVKKLL-PGARWLSKID-IHPRGDNLIASSFDKRVLWHD 708 Query: 421 EE 422 + Sbjct: 709 LD 710 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 46/322 (14%), Positives = 93/322 (28%), Gaps = 37/322 (11%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNF----GIKDKPTFI 150 L A + +L+ P +A GS G + +W + Sbjct: 422 LRPFPIRCSTIYAGH-KGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLID 479 Query: 151 KGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL-------QDFKGNILRVFASSDTINIW 203 I +++NP N A ++ L D + N + + Sbjct: 480 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 539 Query: 204 ----FCSLDVSASSRMVVTGDN-------VGNVILLNMDGKE-----LWNLRMHKKKVTH 247 +L+V+ + G+N V N ++ + KK V Sbjct: 540 GTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKK 599 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 ++ + D+F+ + + QV + + + A F P +L Sbjct: 600 LSWHRKGDYFVTVQPDSGNTSVL-IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 658 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 Q+ +R+Y SQ L+P + L+ I HPR + ++ + Sbjct: 659 QR-YVRIYDLSQQILVKKLLP----GARWLSKIDI--HPRGDNLIASSFDKRVLWHDLDL 711 Query: 368 ELRTIDVFDGNSGKMMCQLYDP 389 + + + Sbjct: 712 ASTPYKTLRYHEKAVRSVNFHK 733 >6EM1-m nrPDB Length = 807 Score = 68.7 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 70/218 (32%), Gaps = 17/218 (7%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 + L+WH V V G+ + + T + G I KF+P Sbjct: 595 KTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD 231 F S R+ D IL W +D+ ++ V+ ++D Sbjct: 655 FVCSQR--YVRIYDLSQQILVKKLLPGA--RWLSKIDIHPRGDNLIASSFDKRVLWHDLD 710 Query: 232 --GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP--- 286 LR H+K V V + ++A+ D T+ ++ +P Sbjct: 711 LASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKK 769 Query: 287 ---HRHP----VNAACFSPDGARLLTTDQKSEIRVYSA 317 H+ V A + P A L + + R+++ Sbjct: 770 LTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 22/79 (27%), Gaps = 1/79 (1%) Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 DLR + S +Y H+ V P G L T +RV+ Sbjct: 421 DLRPFPIRCSTIY-AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLID 479 Query: 331 HRHFQHLTPIKAAWHPRYN 349 W+P N Sbjct: 480 DEENPDYHIECIEWNPDAN 498 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 233 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP-- 290 + HK KV ++++P W LAT S D TV++W++ R +P Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDY 486 Query: 291 -VNAACFSPDGA 301 + ++PD Sbjct: 487 HIECIEWNPDAN 498 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 43/302 (14%), Positives = 93/302 (30%), Gaps = 47/302 (15%) Query: 148 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL----RVFASSDTINIW 203 G G + L +P S +GT R+ + + + + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 204 FCSLDVSASSR----MVVTGDNVGNVI--LLN-----------MDGKELWNLRMHKKKVT 246 ++ + + V G+N+ ++ + DG KK Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 247 HVALNPCCDW----FLATASVDQTVKIWDL-RQVRGKASFLYSLPHRHPVNAACFSPDGA 301 V N D A +V + V W+ Q + + ++ + V + G Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 302 RLLTTDQK-SEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN 360 +T V L P + + + + A +HP + V Sbjct: 608 YFVTVQPDSGNTSVLIH---QVSKHLTQSPFKKSKGII-MDAKFHPFKPQLFVCS----- 658 Query: 361 FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQ 420 R + ++D + ++ +L P + +S ++ +P GD L ++ ++W Sbjct: 659 --------QRYVRIYDLSQQILVKKLL-PGARWLSKID-IHPRGDNLIASSFDKRVLWHD 708 Query: 421 EE 422 + Sbjct: 709 LD 710 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 46/322 (14%), Positives = 93/322 (28%), Gaps = 37/322 (11%) Query: 95 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNF----GIKDKPTFI 150 L A + +L+ P +A GS G + +W + Sbjct: 422 LRPFPIRCSTIYAGH-KGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLID 479 Query: 151 KGIGAGGSITGLKFNPLNTNQFYASSMEGTTRL-------QDFKGNILRVFASSDTINIW 203 I +++NP N A ++ L D + N + + Sbjct: 480 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 539 Query: 204 ----FCSLDVSASSRMVVTGDN-------VGNVILLNMDGKE-----LWNLRMHKKKVTH 247 +L+V+ + G+N V N ++ + KK V Sbjct: 540 GTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKK 599 Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 ++ + D+F+ + + QV + + + A F P +L Sbjct: 600 LSWHRKGDYFVTVQPDSGNTSVL-IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS 658 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 Q+ +R+Y SQ L+P + L+ I HPR + ++ + Sbjct: 659 QR-YVRIYDLSQQILVKKLLP----GARWLSKIDI--HPRGDNLIASSFDKRVLWHDLDL 711 Query: 368 ELRTIDVFDGNSGKMMCQLYDP 389 + + + Sbjct: 712 ASTPYKTLRYHEKAVRSVNFHK 733 >5A9Q-0 nrPDB Length = 380 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 45/113 (39%), Gaps = 8/113 (7%) Query: 213 SRMVVTGDNVGNVILLNMDGK-----ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV 267 + ++T +++G + + + + ++ +L + + V +P +AT D + Sbjct: 183 TPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGML 242 Query: 268 KIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG-ARLLTTDQKSEIRVYSASQ 319 IWD+RQ S L H + F P L T + + + AS Sbjct: 243 SIWDVRQGTMPVSLLK--AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAST 293 Score = 58.3 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 108/339 (31%), Gaps = 52/339 (15%) Query: 112 RRATSLAWHPTHPSTVAVG---------SKGGDIMLW----------NFGIKDKPTFIKG 152 ++ + W P P ++ ++ I LW + G + + Sbjct: 11 QKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCD 70 Query: 153 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 212 I G + L+F + + A+S G + N + + + + S S Sbjct: 71 IRHHGDVMDLQF--FDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPS 128 Query: 213 -SRMVVTGD--NVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWF----------LA 259 S TG N ++ + DG+ HK+ V + N + Sbjct: 129 YSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTID-NADSSTLHAVTFLRTPEIL 187 Query: 260 TASVDQTVKIWDLRQVRGKASFLYSL-PHRHPVNAACFSPDGARL-LTTDQKSEIRVYSA 317 T + +KIWD RQ + S + SL R P++ P+ + T Q + ++ Sbjct: 188 TVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDV 247 Query: 318 SQWDCPLGLI-PHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY----ELRTI 372 Q P+ L+ H ++ +HP + D + E ++ Sbjct: 248 RQGTMPVSLLKAHEAEMWE------VHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSL 301 Query: 373 DVFDGNSGKMMCQLYDP----ESSGISSLNEFNPMGDTL 407 G S + S ISS +P D + Sbjct: 302 FHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRI 340 Score = 31.4 bits (69), Expect = 0.76, Method: Composition-based stats. Identities = 15/109 (13%), Positives = 33/109 (30%), Gaps = 8/109 (7%) Query: 71 RTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVG 130 QH + + + + + +HP++P + Sbjct: 226 HPNQQHVVATGGQDGMLSIWDVR-----QGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTC 280 Query: 131 SKGGDIMLWNFGI---KDKPTFIKGIGAGGSITGLKFNPLNTNQFYASS 176 S+ G + W+ + F +G + ++ N N +Q SS Sbjct: 281 SEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISS 329 >5CXB-B nrPDB Length = 369 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 67/216 (31%), Gaps = 16/216 (7%) Query: 112 RRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQ 171 +++WH V G + + T I G F+PL Sbjct: 157 STIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLF 216 Query: 172 FYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVIL--LN 229 F A+ + R D + L + W S DV +V G ++ L+ Sbjct: 217 FVATQR--SIRCYDLQ--KLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRLLWHDLD 272 Query: 230 MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRH 289 + + +R H + + V + A AS D +++I+ + + +P + Sbjct: 273 LSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKM 332 Query: 290 P----------VNAACFSPDGARLLTTDQKSEIRVY 315 V + P ++ R++ Sbjct: 333 LKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 87/272 (31%), Gaps = 72/272 (26%) Query: 206 SLDVSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKK-VTHVALNPCCDWFL--ATA 261 S+ + + + TG + G V + + G+++W+++++ + V V P D F+ A A Sbjct: 26 SVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAA 85 Query: 262 SVD---------QTVKIWD------LRQVRGKAS-------------------------- 280 D D L G A+ Sbjct: 86 GEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGKWARPGTRLE 145 Query: 281 ---FLYSLPHRHPVNAACFSPDGARLLT---TDQKSEIRVYSASQWDCPLGLIPHPHRHF 334 L + R + A + G T + Q+S + +++ S L P R Sbjct: 146 DEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLS-----KHLTQIPFRKL 200 Query: 335 QHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGI 394 L A++HP L V + + +L + + P + I Sbjct: 201 NGLAQ-TASFHPLRPLFFVA--TQRSIRCYDLQKLELVKI------------VQPGAKWI 245 Query: 395 SSLNEFNPMGDTLASAMGYHILIWSQEEARTR 426 SS + +P GD L L+W + R Sbjct: 246 SSFD-VHPGGDNLVVGSYDKRLLWHDLDLSNR 276 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 32/76 (42%), Gaps = 3/76 (3%) Query: 236 WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAAC 295 R H+ +V VA++P LAT D TV++W+L + G+ + L VN Sbjct: 15 TIFRGHEGRVRSVAIDPTG-VALATGGDDGTVRVWEL--LTGRQVWSVKLNGDEAVNTVR 71 Query: 296 FSPDGARLLTTDQKSE 311 + P + E Sbjct: 72 WRPTKDTFILAAAAGE 87 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 10/70 (14%), Positives = 18/70 (25%), Gaps = 5/70 (7%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 345 H V + P G L T +RV+ + + W Sbjct: 19 GHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVN-----TVRWR 73 Query: 346 PRYNLIVVGR 355 P + ++ Sbjct: 74 PTKDTFILAA 83 >3JB9-S nrPDB Length = 488 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 66/373 (17%), Positives = 123/373 (32%), Gaps = 46/373 (12%) Query: 8 ETQKTSEIVLRPRNKRSRSPLELEPEA--KKLCAKGSGPSRRCDSDCLW-VGLAGPQILP 64 +T + E+ + + + ++ L E ++L +K +R W A Q+L Sbjct: 142 KTIEVQEVEMGESDDQLKTSLRSTVEKTFQELSSKR----KRTKLQPKWATDDAVSQLLQ 197 Query: 65 PCRSIVRTLHQHKLGRASWPSVQQ-----GLQQSFLHTLDSYRILQKAAPFDRRATSLAW 119 S + + + + +PS + L + L LD F+ A + W Sbjct: 198 ATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSN-STLKIFEGSALACCW 256 Query: 120 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG-----SITGLKFNPLNTNQFYA 174 S +AV + I ++ F + G + L+ +P A Sbjct: 257 --LTSSKIAVATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAA 313 Query: 175 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GK 233 S+ + K + + T+ SL V + V G G + G Sbjct: 314 SNEKCYI--FSLKSQVYNI-----TVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGN 366 Query: 234 ELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNA 293 EL H V + W + T + D + IWDLR K+ + +P + V A Sbjct: 367 ELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLR----KSELVQKIPLQTKVAA 422 Query: 294 ACFSPDGARLLTTDQKSE---IRVYSASQWDCPLGLIPHPHRHFQHLTPIK-AAWHPRYN 349 L+++D ++ I V S+ W C H++ I W + Sbjct: 423 VSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQ---------THVSSISNLVWLNELH 473 Query: 350 LIVVGRYPDPNFK 362 ++ + Sbjct: 474 QLLFSTSNGAILR 486 >6E29-D nrPDB Length = 345 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 37/240 (15%), Positives = 77/240 (32%), Gaps = 18/240 (7%) Query: 183 LQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKEL-WNLRMH 241 LQD+ NI S + + + + +G G V++ +++ + LR H Sbjct: 12 LQDYPENITNTIRSGHST-----CVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGH 66 Query: 242 KKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP--D 299 K +T ++ + C + L+ + + +WDL+ + R PV A P Sbjct: 67 SKNITSLSWSRCGRYLLSACQGWKVI-LWDLQ----DGKRYREVRFRAPVYGAELHPWNH 121 Query: 300 GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN---LIVVGRY 356 + + V + L P R P + + + Y Sbjct: 122 HQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVY 181 Query: 357 PDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHIL 416 +++ D + +++ + +SGI + G L I+ Sbjct: 182 TASGDHLLAGTTKGRLNIIDARTREIIYS--EKIASGIITTLRLTESGRELLVNAQDRII 239 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 35/205 (17%), Positives = 69/205 (33%), Gaps = 22/205 (10%) Query: 140 NFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDT 199 ++ ++D P I G T ++FN + + ++GT + D + + + Sbjct: 9 DYLLQDYPENITNTIRSGHSTCVRFNRKG-DFLASGRVDGTVVIWDLETMGVARKLRGHS 67 Query: 200 INIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLA 259 NI SL S R +++ VIL ++ + + + V L+P A Sbjct: 68 KNI--TSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFA 125 Query: 260 TASVDQTVKIWDLRQVRGKASFLYSLP-------------------HRHPVNAACFSPDG 300 A + + D+ + L S+P +H A ++ G Sbjct: 126 AALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASG 185 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLG 325 LL K + + A + Sbjct: 186 DHLLAGTTKGRLNIIDARTREIIYS 210 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 27/74 (36%), Gaps = 6/74 (8%) Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA-CFSPDGARLL 304 HVA + ++ A+ + + IW+ RG S + L + P A L Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWE----RGHGSLVRMLEGPKEEQGVIEWHPHRALLA 330 Query: 305 TTDQK-SEIRVYSA 317 + I ++S Sbjct: 331 ACGLETGRINIWSV 344 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 24/85 (28%), Gaps = 3/85 (3%) Query: 191 LRVFASSDTINIWFCSLDVSASSRMVVTGD-NVGNVILLNM-DGKELWNLRMHKKKVTHV 248 F W + SA+ V N + + G + L K++ + Sbjct: 262 EHKFQDVVNRLSW-NHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVI 320 Query: 249 ALNPCCDWFLATASVDQTVKIWDLR 273 +P A + IW + Sbjct: 321 EWHPHRALLAACGLETGRINIWSVT 345 >5WLC-LN nrPDB Length = 776 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 42/257 (16%), Positives = 83/257 (32%), Gaps = 20/257 (7%) Query: 157 GSITGLKF-NPLNTNQFYASSME-------GTTRLQDFKGN--ILRVFASSDTINIWFCS 206 +IT L F + N N+ S + G + + + N V +I Sbjct: 44 ATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLC 103 Query: 207 LD-VSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVD 264 V+ S + + V ++ G L N + + +++N L+ + Sbjct: 104 WSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISIN-DSQDKLSVGCDN 162 Query: 265 QTVKIWDLRQVRGK-ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323 TV + D+ G + V + D + IR++SA + D Sbjct: 163 GTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCS-DGRIRIWSAQKNDEN 221 Query: 324 LGLIPHPHRHFQHLTPIKAAWH----PRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNS 379 +G + H + + W PR + I G + K F + Sbjct: 222 MGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDST-GSIKFWDFQFATLNQSFKAHD 280 Query: 380 GKMMCQLYDPESSGISS 396 ++C D +++ + S Sbjct: 281 ADVLCLTTDTDNNYVFS 297 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 99/311 (31%), Gaps = 40/311 (12%) Query: 122 THPSTVAVGSKGGDIMLWNFGIKDKPTFI--KGIGAGGSITGLKFNPLNTNQFYASSMEG 179 ++VG G ++L + + + L + + +G Sbjct: 151 DSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD--FVIGGCSDG 208 Query: 180 TTRLQDFKGNILRVF----------ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 229 R+ + N + A ++ +W S+ + + +GD+ G++ + Sbjct: 209 RIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVW--SVIYLPRTDQIASGDSTGSIKFWD 266 Query: 230 MDGKELW-NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS-------F 281 L + + H V + + ++ +A VD+ KI+ Q K+ Sbjct: 267 FQFATLNQSFKAHDADVLCLTTDTDNNYVF-SAGVDR--KIFQFSQNTNKSQKNNRWVNS 323 Query: 282 LYSLPHRHPVNAACF--SPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 L H + + A C S L++ + + + S + + +R + P Sbjct: 324 SNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGN------YRKMPTVEP 377 Query: 340 IKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE 399 +V + + K T D + K++C+L + I S Sbjct: 378 YSKNVLVNKEQRLVVSWSESTVKIWTM----GTDSSTEQNYKLVCKLTLKDDQNI-STCS 432 Query: 400 FNPMGDTLASA 410 +P G L Sbjct: 433 LSPDGQVLVVG 443 Score = 32.9 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 25/204 (12%), Positives = 55/204 (26%), Gaps = 22/204 (10%) Query: 222 VGNVILLNMDGKELWNLR-MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 280 V ++ + +L HK + + + D LA + ++IW+ R + Sbjct: 33 VHRCRFVDFTPATITSLAFSHKSNINKLTPS---DLRLAIGRSNGNIEIWNPRNNWFQEM 89 Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 + + C+S +R++S ++ Sbjct: 90 VIEG-GKDRSIEGLCWSNVNGE--------SLRLFSIGGSTVVTEWDLATGLPLRN---- 136 Query: 341 KAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFD--GNSGKMMCQLYDPESSGISSLN 398 + +I D K + T+ + D G G + Sbjct: 137 ---YDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTL 193 Query: 399 EFNPMGDTLASAMGYHILIWSQEE 422 + + I IWS ++ Sbjct: 194 AWKKDDFVIGGCSDGRIRIWSAQK 217 >5K0Y-T nrPDB Length = 329 Score = 65.3 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 58/204 (28%), Gaps = 38/204 (18%) Query: 111 DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTN 170 D + TS W P + G + G++ + K + I ++ + Sbjct: 146 DSKITSAVWGPL-GECIIAGHESGELN--QYSAKSGEVLVNVKEHSRQINDIQLS-REMT 201 Query: 171 QFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 230 F +S + T +L D + ++ +S + VV G + + Sbjct: 202 MFVTASKDNTAKLFDSTTLEHQKTFRTEP---PRELAALSPNYEHVVVGG-GQEAMDVTT 257 Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 + H+A + F H P Sbjct: 258 TSTRIGKFEAR---FFHLAF---------------------------EEEFGRVKGHFGP 287 Query: 291 VNAACFSPDGARLLTTDQKSEIRV 314 +N+ F PDG + + +R+ Sbjct: 288 INSVAFHPDGKSYSSGGEDGYVRI 311 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 78/232 (33%), Gaps = 23/232 (9%) Query: 154 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASS 213 G SIT +K+N + + + + + T +W +D + Sbjct: 8 GHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW--CVDADWDT 64 Query: 214 RMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQT------ 266 + V+TG + L + GK+L L+ + V + + + S D+ Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMF--STDKQMGYQCF 121 Query: 267 VKIWDLR---QVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCP 323 V +DLR Q+ ++ + + +A + P G ++ + E+ YSA + Sbjct: 122 VSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVL 181 Query: 324 LGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVF 375 + + H + I R + V D K L F Sbjct: 182 VNVKEHSRQ-------INDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTF 226 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 39/118 (33%), Gaps = 11/118 (9%) Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 297 L+ H++ +T + N D L T + D V +W V G+ Y + H V Sbjct: 6 LQGHERSITQIKYNREGD-LLFTVAKDPIVNVW--YSVNGERLGTY-MGHTGAVWCVDAD 61 Query: 298 PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGR 355 D +LT + R++ L + + N+I+ Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVR-------TCGFDFGGNIIMFST 112 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 13/99 (13%), Positives = 32/99 (32%), Gaps = 7/99 (7%) Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 345 H + ++ +G L T + + V+ + + + H + + A W Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW----CVDADWD 63 Query: 346 PRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMC 384 ++ L D + + + + + NS C Sbjct: 64 TKHVLTGSA---DNSCRLWDCETGKQLALLKTNSAVRTC 99 >1PI6-A nrPDB Length = 615 Score = 65.3 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 35/253 (13%), Positives = 81/253 (32%), Gaps = 16/253 (6%) Query: 97 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWN-FGIKDKPTFIKGIGA 155 + DS L + + +R + + P G ++ + K + Sbjct: 146 SWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQ 205 Query: 156 GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS-ASSR 214 G + ++F+P + + D K + D + +S S+ Sbjct: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 Query: 215 MVVTGDNVGNVILLNMDGKEL---WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 271 T + + ++ + W L + V + + + + S+D T+ ++ Sbjct: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYE 325 Query: 272 LRQVRGKASFLYSL-PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ--WDCPLGLIP 328 L G L ++ H + A +P L++ I +S+S D ++ Sbjct: 326 L----GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVS 377 Query: 329 HPHRHFQHLTPIK 341 + Q + I Sbjct: 378 LDNSKAQEYSSIS 390 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 28/236 (11%), Positives = 66/236 (27%), Gaps = 20/236 (8%) Query: 134 GDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRV 193 G + W+ + + G I + +G+ Sbjct: 142 GVFISWD----SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSA 197 Query: 194 FASSDTIN-IWFCSLDVSA-SSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTH--V 248 + + ++ S S V+T + + + G+ L + ++ V Sbjct: 198 SDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIF 257 Query: 249 ALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQ 308 AL+ AT D T+++WD+ + + + R+++ Sbjct: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 Query: 309 KSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSC 364 + Y + + H + +T + N ++ G Y D Sbjct: 318 DGTLNFYELGHDEVLKTISGHN----KGITALTV------NPLISGSY-DGRIMEW 362 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 92/309 (29%), Gaps = 48/309 (15%) Query: 122 THPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTT 181 T + S G + + G + G IT L NP + S +G Sbjct: 307 TGNGRIISLSLDGTLNFYELGHDE--VLKTISGHNKGITALTVNP-----LISGSYDGRI 359 Query: 182 RLQDFKG-----NILRVFASSDTIN-----IWFCSLDVSA-------SSRMVVTGDNVGN 224 + L V + W +L V+ S V + +N G Sbjct: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 Query: 225 VILLNMDGKELWNLRMHKKKVTHVALNPCCDW------FLATASVDQ-TVKIWDLRQVRG 277 +L D L + V LN ++A + T++++ L + Sbjct: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDL-- 477 Query: 278 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHL 337 + SF P R + SP + D +I +Y + + F+ Sbjct: 478 EVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE-----VKTSRWAFRTS 532 Query: 338 TPIKAAWHP----------RYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLY 387 +W P +L+ G F ++ I + + + L+ Sbjct: 533 KINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW 592 Query: 388 DPESSGISS 396 + S+ +SS Sbjct: 593 ETPSTLVSS 601 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 81/279 (29%), Gaps = 41/279 (14%) Query: 160 TGLKFNPLNTNQFYASSMEGTTRLQDFKGNILR-VFASSDTINIWFCSLDVSA--SSRMV 216 T L ++P Y R D + + V + + ++ S S+ + Sbjct: 22 THLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYL 81 Query: 217 VTGDNVGNVILLNMDGKELWN---------LRMHKKKVTHVALNPCCDWFLATA-SVD-- 264 +GD G VI+ + N ++ ++ ++ + D Sbjct: 82 CSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNF 141 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG-ARLLTTDQKSEIRVYSASQWDCP 323 WD G+ S H +NA R +T + Y P Sbjct: 142 GVFISWDSGNSLGEVS-----GHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGP----P 192 Query: 324 LGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM- 382 H + + ++ PD T R I FDG SG+ Sbjct: 193 FKFSASDRTHHKQGSFVRDVEF----------SPDSGEFVITVGSDRKISCFDGKSGEFL 242 Query: 383 --MCQLYDPESSGISSLNEFNPMGDTLAS-AMGYHILIW 418 + +P GI +L+ + A+ I +W Sbjct: 243 KYIEDDQEPVQGGIFALSWLD--SQKFATVGADATIRVW 279 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 61/151 (40%), Gaps = 23/151 (15%) Query: 187 KGNILRVFASSD---------TINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN 237 +GN ++VF SD + + +S S + GD +G ++L ++ +E+ Sbjct: 465 EGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKT 524 Query: 238 LR--MHKKKVTHVALNPC---------CDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 R K+ ++ P + +AT S+D + I+ +++ L Sbjct: 525 SRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALN--A 582 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSA 317 H+ VN + L+++ + I+ ++ Sbjct: 583 HKDGVNNLLWETPST-LVSSGADACIKRWNV 612 >6BX3-B nrPDB Length = 412 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 72/202 (35%), Gaps = 20/202 (9%) Query: 206 SLDVSASSRMVVTGDNVGNVILLNMDGK---EL--WNLRMHKKKVTHVALNPCCDWFLAT 260 L S + G G +++ +MD + L H + +T +A +P L T Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL-T 88 Query: 261 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD--QKSEIRVYSAS 318 +S D ++K+WDL + + L + P+ + RL ++S+ V S Sbjct: 89 SSRDWSIKLWDLSKP---SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 145 Query: 319 QWDCPLGLIPHPHRHFQHLTP-----IKAAWHPRY-NLIVVGRYPD--PNFKSCTPYELR 370 D L+ TP + H ++ N+I+VG +K + Y+ Sbjct: 146 N-DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTE 204 Query: 371 TIDVFDGNSGKMMCQLYDPESS 392 I S + + Sbjct: 205 CIHSLKITSSNIKHLIVSQNGE 226 Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 53/334 (15%), Positives = 94/334 (28%), Gaps = 36/334 (10%) Query: 90 LQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTF 149 LQ F + L R L + P +A+G G +++++ Sbjct: 4 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICV 62 Query: 150 IKGI--GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC-- 205 + IT + ++P SS + + +L D + IW C Sbjct: 63 PGNMLGAHVRPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW 121 Query: 206 -------SLD--VSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCCD 255 + S V+ N LL+ D K+L + H + + Sbjct: 122 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 181 Query: 256 WFLATASVDQTVKIWDLRQVRGKASFLYSLPH-----RHPVNAACFSPDGARLLTTDQKS 310 + T K W L + + + H + S +G RL Sbjct: 182 IIIV-----GTSKGW-LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR 235 Query: 311 EIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH--------PRYNLIVVGRYPDPNFK 362 IR Y S D + +Q + K W+ Y + Sbjct: 236 TIRQYEISIDDENSAVELTLEHKYQDVIN-KLQWNCILFSNNTAEYLVASTHGSSAHELY 294 Query: 363 SCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 + V +G +++ +D S I S Sbjct: 295 IWETTSGTLVRVLEGAEEELIDINWDFYSMSIVS 328 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 22/167 (13%), Positives = 50/167 (29%), Gaps = 15/167 (8%) Query: 120 HPTHPSTVAVGSKGGDIMLWNF-GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSME 178 H HP+ + VG+ G + + F + +I L + S + Sbjct: 176 HTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCS-D 234 Query: 179 GTTRLQDFK---GNILRVFASSDTIN------IWFCSLDVSASSRMVVT---GDNVGNVI 226 T R + N W C L + ++ +V G + + Sbjct: 235 RTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELY 294 Query: 227 LL-NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 272 + G + L ++++ + + ++ V +W + Sbjct: 295 IWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 >4OWR-A nrPDB Length = 339 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 52/152 (34%), Gaps = 15/152 (9%) Query: 243 KKVTHVALNPCC--DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 300 + ++ +P FL S V+ W++ Q G+ H PV C+S DG Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV-QDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA-W--HPRYNLIVVGRYP 357 +++ T +++ S + QH P+K W P Y+ ++ G + Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAI--------QIAQHDAPVKTIHWIKAPNYSCVMTGSW- 120 Query: 358 DPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 389 D K + V + P Sbjct: 121 DKTLKFWDTRSSNPMMVLQLPERCYCADVIYP 152 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 38/298 (12%), Positives = 69/298 (23%), Gaps = 40/298 (13%) Query: 81 ASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWN 140 SW + + + I + + W S V S +W+ Sbjct: 31 GSWANDVRCWEVQD----SGQTIPKAQQMHTGPVLDVCWS-DDGSKVFTASCDKTAKMWD 85 Query: 141 FGIKDKPTFIKGIGAGGSITGLKFNPL-NTNQFYASSMEGTTRLQDFKGNI-LRVFASSD 198 I+ + + + N + S + T + D + + + V + Sbjct: 86 LSSNQA---IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPE 142 Query: 199 TINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM---HKKKVTHVAL---NP 252 DV +V T + V L E + H+ VA+ Sbjct: 143 RCY----CADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQH--RCVAIFKDKQ 196 Query: 253 CCDWFLATASVDQTVKIWDLR-------QVRGKASFLYSLPHRHP-----VNAACFSPDG 300 A S++ V I + K P VN F P Sbjct: 197 NKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVH 256 Query: 301 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 L T + + ++ N+ D Sbjct: 257 GTLATVGSDGRFSFWDKDARTKLKT-SEQLDQPIS-----ACCFNHNGNIFAYASSYD 308 >5YZG-2 nrPDB Length = 646 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 71/208 (34%), Gaps = 23/208 (11%) Query: 127 VAVGSKGGDIMLWNFGIKDKPTFIK-GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185 + S G + W I++ F+K G I + + F + + ++ D Sbjct: 104 IITASHDGHVKFWK-KIEEGIEFVKHFRSHLGVIESIAVSSEGA-LFCSVGDDKAMKVFD 161 Query: 186 FKGNILRVFASSDTIN---IWFCSLDVSASSRMVVTGDNVGNVILLNMDG--KELWNL-R 239 + W A S + + + G + + + G + L + Sbjct: 162 VVNFDMINMLKLGYFPGQCEWIYC-PGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDK 220 Query: 240 MHKKKVTHVALNPCCDWFLATASVDQTVKIW-----------DLRQVRGKASFLYSLPH- 287 +H +T + LNP + ++ ++ W ++ + LY Sbjct: 221 LHTSPLTQIRLNPVYKA-VVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKC 279 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVY 315 + + CFSPDG ++ T ++R++ Sbjct: 280 KAYPTSVCFSPDGKKIATIGSDRKVRIF 307 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 33/264 (12%), Positives = 81/264 (30%), Gaps = 35/264 (13%) Query: 137 MLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ-DFKGNILRVFA 195 ++ + + + IT + + +S +G + + I V Sbjct: 71 RVYLDNLPSASMYERSYMHRDVITHVVCTKTD--FIITASHDGHVKFWKKIEEGIEFVKH 128 Query: 196 SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN------MDGKELWNLRMHKKKVTHVA 249 + + S+ VS+ + + + + + + ++ +L + + Sbjct: 129 FRSHLGV-IESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC-- 185 Query: 250 LNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP--HRHPVNAACFSPDGARLLTTD 307 P AS T KI+ + RG L+ H P+ +P ++++D Sbjct: 186 --PGDAISSVAASEKSTGKIF-IYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSD 242 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLT-------------PIKAAWHPRYNLIVVG 354 + I ++ P + ++++ T P + P I Sbjct: 243 KSGMIEYWTGP----PHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATI 298 Query: 355 RYPDPNFKSCTPYELRTIDVFDGN 378 D + + + VFD + Sbjct: 299 GS-DRKVRIFRFVTGKLMRVFDES 321 >3F3P-A nrPDB Length = 351 Score = 61.8 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 43/331 (12%), Positives = 99/331 (29%), Gaps = 52/331 (15%) Query: 123 HPSTVAVGSKGGDIMLW--NFGIKDKPTFIKGIGAGGSITGLKF-NPLNTNQFYASSMEG 179 + VA S I ++ + + SI + + +P ++S + Sbjct: 22 YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDK 81 Query: 180 TTRLQ-------DFKGNILRVFASSDTINIWFCSLDVSAS--SRMVVTGDNVGNVILL-- 228 T +L + G + + S+ + + + N G + L Sbjct: 82 TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 141 Query: 229 ----NMDGKELWNL--------RMHKKKVTHVALNP--CCDWFLATASVDQTVKIWDLRQ 274 ++ L + H + ++ P LA ++++Q + R Sbjct: 142 LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIY--QRG 199 Query: 275 VRGKASFLYSLP-HRHPVNAACFSPD-GAR---LLTTDQKSEIRVYSASQWDCPLGLIPH 329 GK LP H+ + + ++P G + T + IR++ L P Sbjct: 200 KDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF-----KITEKLSPL 254 Query: 330 PHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 389 + + ++ GR + +++ + Sbjct: 255 ASEESLTNSNMFDN-SADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD--------- 304 Query: 390 ESSGISSLNEFNPMGDTLASAMGY-HILIWS 419 + + S+ +N G L+SA + +W Sbjct: 305 HNGEVWSV-SWNLTGTILSSAGDDGKVRLWK 334 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 63/177 (35%), Gaps = 24/177 (13%) Query: 191 LRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG-----KELWNLRMHKKKV 245 ++ F S + D R V T + ++ + +D + + R H + Sbjct: 3 MQPFDSGHDDLVHDVVYDF--YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 60 Query: 246 THVAL-NPCCDWFLATASVDQTVKIWDLRQVRGKAS------FLYSLPHRHPVNAACFSP 298 + +P +A+AS D+TVK+W+ + + S + + + F+P Sbjct: 61 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 120 Query: 299 D--GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 G +L +R+Y A L P R + + +K P N + Sbjct: 121 AHLGLKLACLGNDGILRLYDA--------LEPSDLRSWTLTSEMKVLSIPPANHLQS 169 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 36/122 (29%), Gaps = 8/122 (6%) Query: 281 FLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPI 340 + H V+ + G + T I+V+ + L H + I Sbjct: 4 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 63 Query: 341 KAAWHPRYNLIVVGRYP--------DPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESS 392 A +I Y DP+ + C+ + + + G + + P Sbjct: 64 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 123 Query: 393 GI 394 G+ Sbjct: 124 GL 125 >5K19-A nrPDB Length = 569 Score = 61.4 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 84/242 (34%), Gaps = 40/242 (16%) Query: 192 RVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKK-----KVT 246 R++ + F L +A S ++ G + G V L++ KE L ++ +VT Sbjct: 94 RIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVT 153 Query: 247 HVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP---------------- 290 V P + A + ++++ G + Y L + Sbjct: 154 CVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPL 213 Query: 291 ---------VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 +N FSPDG L Q +RV++ + L +F L + Sbjct: 214 LKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS----VELHGTMKSYFGGL--LC 267 Query: 342 AAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFN 401 W P IV G D + + R I G+ + +DP ++ S+ E + Sbjct: 268 VCWSPDGKYIVTGG-EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTT---SVEEGD 323 Query: 402 PM 403 PM Sbjct: 324 PM 325 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 84/280 (30%), Gaps = 24/280 (8%) Query: 33 EAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLH--QHKLGR-ASWPSVQQG 89 E KL + + + WV + L S L+ +H G A + + Sbjct: 136 ETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQ 195 Query: 90 LQQSFLHTLDSYRI---LQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFG-IKD 145 + +HT S L K + A+ P +A S+ G + ++NF ++ Sbjct: 196 GESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPD-GKFLACVSQDGFLRVFNFDSVEL 254 Query: 146 KPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFC 205 T G + + ++P + + F RV A W Sbjct: 255 HGTMKSYFG---GLLCVCWSPDGK-YIVTGGEDDLVTVWSFVD--CRVIARGHGHKSWVS 308 Query: 206 SLDVSASS-------RMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCC-DWF 257 + + M +G + LL+ + + K P + Sbjct: 309 VVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYR 368 Query: 258 LATASVDQTVKIWDLRQVRGKASFLYSLP--HRHPVNAAC 295 + D + +WDL + S H + +NA Sbjct: 369 FGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATS 408 >3I2N-A nrPDB Length = 357 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 46/281 (16%), Positives = 80/281 (28%), Gaps = 47/281 (16%) Query: 72 TLHQHKLGRASWPSVQQGLQ----QSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTV 127 +L Q L + + ++++ ++ + A P + Sbjct: 77 SLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAP----EI 132 Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGA-----GGSITGLKF---NPLNTNQFYASSMEG 179 GS+ G + +W+ KD P + + + F A G Sbjct: 133 VTGSRDGTVKVWDPRQKDDP--VANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNG 190 Query: 180 TTRLQDFKGNILRVFASSDTINIWFCSLDVSA---SSRMVVTGDNVGNVILLNM------ 230 +L D + LR I CSL+ S +V G + +M Sbjct: 191 DIKLFDLRNMALRWET---NIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPT 247 Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR---QVRGKASFLYSLPH 287 G + + HK V V P TA + +W Q K S + Sbjct: 248 KGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGV 307 Query: 288 RH-------------PVNAACFSPDGARLLTTDQ-KSEIRV 314 P+++ +SPD L +RV Sbjct: 308 AGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 29/184 (15%), Positives = 67/184 (36%), Gaps = 18/184 (9%) Query: 154 GAGGSITGLKFNPLNTNQFYASSM---EGTTRLQDFKGNILRVFASSDTINIWFCSL--D 208 G ++ K+ P + + G +L + + L++ + C Sbjct: 16 GFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGA 75 Query: 209 VSASSRMVVTGDNVGNVILLNMDGKE--LWNLRMHKKKVTHVALNPCCDWF-----LATA 261 S R + TGD GN+ + N++ E +++++ HK+ + + + T Sbjct: 76 TSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTG 135 Query: 262 SVDQTVKIWDLRQVRGKASFLYSLPHRHP------VNAACFSPDGARLLTTDQKSEIRVY 315 S D TVK+WD RQ + + + + ++ + + +I+++ Sbjct: 136 SRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLF 195 Query: 316 SASQ 319 Sbjct: 196 DLRN 199 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 37/223 (16%), Positives = 74/223 (33%), Gaps = 24/223 (10%) Query: 201 NIWFCSLDVSASSRMVVTGDN---VGNVILLNMDGKELWNLRM--HKKKVTHVALNPCC- 254 F V S++ V G+ G + L + +L LR K + Sbjct: 19 YTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSL 78 Query: 255 -DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGA------RLLTTD 307 +LAT + IW+L + H+ +NA ++T Sbjct: 79 QQRYLATGDFGGNLHIWNLEAPEMPVYSVK--GHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNL---IVVGRYPDPNFKSC 364 + ++V+ Q D P+ + P + A+ YN +V Y + + K Sbjct: 137 RDGTVKVWDPRQKDDPVANM-EPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIK-- 193 Query: 365 TPYELRTIDVFDGNS--GKMMCQLYDPESSGISSLNEFNPMGD 405 ++LR + + + + +D + ++ L + G Sbjct: 194 -LFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGK 235 >5WLC-LW nrPDB Length = 554 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 52/161 (32%), Gaps = 14/161 (8%) Query: 207 LDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 265 LD ++VT G + ++ G+ + LR +A NP + + + Sbjct: 196 LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNP-WNAVMHLGHSNG 254 Query: 266 TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLG 325 TV +W + L R PVN+ G + TT ++++ + Sbjct: 255 TVSLW---SPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHS 311 Query: 326 LIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTP 366 + P TP L+ + R P + Sbjct: 312 VESLP-------TPGTNVSISDTGLLALSRGP--HVTLWKD 343 >5OQL-X nrPDB Length = 630 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 26/192 (13%), Positives = 58/192 (30%), Gaps = 18/192 (9%) Query: 145 DKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWF 204 DK T+ + G++T + P Y ++ +G + N W Sbjct: 159 DKATYTQFRWNSGTVTSVAVCPP---YAYTTTKDGYLTKWKLQDL---------PKNQWP 206 Query: 205 CSLDVSASSRMVVTGDNVGNVILLNMDGKELW--NLRMHKKKVTHVALNPCCDWFLATAS 262 + + D ++ + H K V + + + T Sbjct: 207 QTTKKKPKKPPAPPKKRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKF-VVTGG 265 Query: 263 VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 322 D+ + +++ ++ +F HR V F +L + + ++V+S + Sbjct: 266 ADKRLVVYNAADLKPIKAFTQ---HRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAY 322 Query: 323 PLGLIPHPHRHF 334 L H Sbjct: 323 VETLFGHQDEIL 334 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 35/280 (12%), Positives = 79/280 (28%), Gaps = 62/280 (22%) Query: 60 PQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAW 119 + P + + + + L + ++ + A T LA+ Sbjct: 244 GHLKAPL-VVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDA------VTGLAF 296 Query: 120 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA-SSME 178 + + SK + +W+ + + G I + + L + + + + Sbjct: 297 RRGT-NQLYSCSKDRTVKVWS--LDELAYVETLFGHQDEILDI--DALGQERCVSVGARD 351 Query: 179 GTTRLQDFKGNILRVFASSD-----TINIWFCSLDVSASS---------------RMVVT 218 T R VF + +S M VT Sbjct: 352 RTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVT 411 Query: 219 GDNVGNVILLNMDGKELWNL--RMHK--------------------------KKVTHVAL 250 G + G++ L ++ K+ ++ R H + +T + Sbjct: 412 GSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRT 471 Query: 251 NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 P D + + S D +++W L + + K + L Sbjct: 472 LPYSD-LIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSE 510 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 33/112 (29%), Gaps = 11/112 (9%) Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 330 D R+ K H S DG ++T + VY+A+ Sbjct: 233 DARKANDKTYQ----GHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFT--- 285 Query: 331 HRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKM 382 QH + R + D K + EL ++ G+ ++ Sbjct: 286 ----QHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEI 333 >6CHG-D nrPDB Length = 439 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 37/290 (12%), Positives = 89/290 (30%), Gaps = 36/290 (12%) Query: 124 PSTVAVGSKGGDIMLWNFGIKDKPTFIKGI---GAGGSITGLKFNPLNTNQFYASSMEGT 180 +AVG G I++++ KP + G S+ + ++ ++S + Sbjct: 39 GDYLAVGCSNGAIIIYDMD-SLKPIAMLGTHSGAHTRSVQSVCWSNDGR-YLWSSGRDWY 96 Query: 181 TRLQDFK--GNILRVFASSDTINI-----WFCS--LDVSASSRMVVTGDNVGNVILLNMD 231 +L D + + + W V + V+T + N Sbjct: 97 AKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPL 156 Query: 232 GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR-----QVRGKASFLYSLP 286 ++ ++ H + +P + + T + + + L + + + + + Sbjct: 157 LEQDQDISGHGYTLVAC-PHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIA 215 Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVY------SASQWDCPLGLIPHPHRHFQHLTPI 340 + SP G R+ IR Y + S+ + +Q + Sbjct: 216 -NANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIIN- 273 Query: 341 KAAWHPRYNLIVVGRYPDPNF---KSCTPYELRT-----IDVFDGNSGKM 382 + W+ + G Y + + Y T + V +G ++ Sbjct: 274 RLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEGADEEL 323 Score = 52.2 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 35/74 (47%), Gaps = 2/74 (2%) Query: 247 HVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF-LYSLPHRHPVNAACFSPDGARLLT 305 V +P D+ LA + + I+D+ ++ A +S H V + C+S DG L + Sbjct: 32 CVKFSPRGDY-LAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWS 90 Query: 306 TDQKSEIRVYSASQ 319 + + +++ +Q Sbjct: 91 SGRDWYAKLWDMTQ 104 Score = 36.4 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 27/100 (27%), Gaps = 7/100 (7%) Query: 288 RHPVNAAC--FSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 345 PV A C FSP G L I +Y L H H + + + W Sbjct: 25 EVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSV--CWS 82 Query: 346 PRYNLIVVGRYPDPNFKSCTPYE-LRTIDVFDGNSGKMMC 384 + D K + + + G + Sbjct: 83 NDGRYLWSSGR-DWYAKLWDMTQPTKCFQQYK-FDGPLWS 120 >5MC6-j nrPDB Length = 397 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 38/278 (13%), Positives = 75/278 (26%), Gaps = 46/278 (16%) Query: 100 SYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG----- 154 S+ + + ++ VA S GD++ + +D+ + Sbjct: 57 SHFVHKSGLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLD 116 Query: 155 ---AGGSITGLKFNPLNTNQF----YASSMEGTTRLQ----------DFKGNILRVFASS 197 S LK+ N A+ ++GTT + N Sbjct: 117 SDMKKHSFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQ 176 Query: 198 DTINIWFCSLDVSASSR-----MVVTGDNVGNVILLNMDG-KELWNLRM------HKKKV 245 T+ + S ++ TG N G V + + + L+N + + Sbjct: 177 GTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSI 236 Query: 246 THVALNPCCDWFLATASVDQTVKIWDLRQVRGKA------------SFLYSLPHRHPVNA 293 V +P + I G+ + L H V + Sbjct: 237 RSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMS 296 Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPH 331 F+ G L + ++R + + L H Sbjct: 297 LSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCD 334 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 21/138 (15%), Positives = 43/138 (31%), Gaps = 17/138 (12%) Query: 239 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA---- 294 + H + V+ C+ F + S D +K+WD + + + S H + Sbjct: 13 KAHDADIFSVS---ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 295 ---CFSPDGARLL---TTDQKSEIRVYSASQWDCPLGLIPH----PHRHFQHLTPIKAAW 344 D L TT ++ Y ++ D +I + + W Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW 129 Query: 345 HPRYNLIVVGRYPDPNFK 362 + ++ R + K Sbjct: 130 GASNDRLLSHRLVATDVK 147 Score = 36.4 bits (82), Expect = 0.023, Method: Composition-based stats. Identities = 38/330 (11%), Positives = 89/330 (26%), Gaps = 71/330 (21%) Query: 152 GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-----------GNILRVFASSDTI 200 G I + + + S +G ++ D K + + + Sbjct: 12 GKAHDADIFSVS---ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHV 68 Query: 201 NIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELW-------------NLRMHKKKVTH 247 ++ + +V T G+++ + ++ +++ H Sbjct: 69 DVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFW--A 126 Query: 248 VALNPCCDWF----LATASVDQTVKIWDLRQVRGK---------ASFLYSLPHRHPVNAA 294 + D L V T IW + + P+ + Sbjct: 127 LKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPS 186 Query: 295 CFS-----PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 F+ + + T +++ S + + P+ + Sbjct: 187 QFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS 246 Query: 350 LIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE---------- 399 L+ + I +++ G+ + L P S +SL E Sbjct: 247 LLAIAH---------DSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSL 297 Query: 400 -FNPMGDTLAS-AMGYHILIWSQEEARTRK 427 FN G+TL S + W + +T++ Sbjct: 298 SFNDSGETLCSAGWDGKLRFW---DVKTKE 324 >3DW8-B nrPDB Length = 447 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 107/316 (33%), Gaps = 60/316 (18%) Query: 79 GRASWPSVQQGLQQSFLHTL----DSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGG 134 GR P+ L+ + ++ A S++ + + + + + Sbjct: 141 GRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYET--YLSADDL 198 Query: 135 DIMLWNFGIKDKPTFIKGIGA------GGSITGLKFNPLNTNQFYASSMEGTTRLQDFKG 188 I LW+ I D+ I I IT +F+P + N F SS +GT RL D + Sbjct: 199 RINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRA 258 Query: 189 NIL-----RVFASSDT---------INIWFCSLDVSASSRMVVTGDNVG-NVILLNMDGK 233 + L ++F + I + S S R ++T D + V LNM+ + Sbjct: 259 SALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMENR 318 Query: 234 ELWNLRMHK--KKVTHVALNPCC------------DWFLATASVDQTVKIWDLRQVRGKA 279 + ++H+ + C D + T S + +++D R + Sbjct: 319 PVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFD-RNTKRDI 377 Query: 280 SFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTP 339 + S + P ++ + ++ D ++ H Sbjct: 378 TLEASRENNKPRTVLK----PRKVCASGKRK---------KDEISVDSLDFNKKILHT-- 422 Query: 340 IKAAWHPRYNLIVVGR 355 AWHP+ N+I V Sbjct: 423 ---AWHPKENIIAVAT 435 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 99/314 (31%), Gaps = 62/314 (19%) Query: 123 HPSTVAVGSKGGDIMLWNFGIKDK---------PTFIKGIGAGGS------------ITG 161 +A G KGG ++++ ++K + I Sbjct: 39 SGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINK 98 Query: 162 LKFNPL-NTNQFYASSMEGTTRLQDFK-------GNILRVFASSDTINIWFCSLDVSASS 213 +++ P N QF S+ + T +L G L+ +L V Sbjct: 99 IRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFR 158 Query: 214 RMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 M +++ + ++ H + +++N + +L ++ D + +W L Sbjct: 159 PM---------DLMVEASPRRIFA-NAHTYHINSISINSDYETYL--SADDLRINLWHLE 206 Query: 274 QVRGKASFLYSLPHRHP-----VNAACFSPDG-ARLLTTDQKSEIRVYSASQW---DCPL 324 + + P + AA F P+ + + K IR+ D Sbjct: 207 ITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS 266 Query: 325 GLIPHP----HRHF--QHLTPIKAA-WHPRYNLIVVGRYPDPNFKSCTPY-ELRTIDVFD 376 L P +R F + ++ I + ++ Y + K E R ++ + Sbjct: 267 KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYL--SVKVWDLNMENRPVETYQ 324 Query: 377 GNS--GKMMCQLYD 388 + +C LY+ Sbjct: 325 VHEYLRSKLCSLYE 338 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 39/288 (13%), Positives = 90/288 (31%), Gaps = 82/288 (28%) Query: 205 CSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKK--------------------- 243 +++ + S ++ TGD G V++ + + ++ H + Sbjct: 32 STVEFNHSGELLATGDKGGRVVIFQQE--QENKIQSHSRGEYNVYSTFQSHEPEFDYLKS 89 Query: 244 -----KVTHVALNPCCD---WFLATASVDQTVKIWDLRQ--------------------- 274 K+ + P + + L+T D+T+K+W + + Sbjct: 90 LEIEEKINKIRWLPQKNAAQFLLST--NDKTIKLWKISERDKRPEGYNLKEEDGRYRDPT 147 Query: 275 ----------------VRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS 318 V +++ H + +N+ + D L+ D I ++ Sbjct: 148 TVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLE 206 Query: 319 QWDCPLGLIPHPHRHFQHLTPI--KAAWHPRYNLIVVGRYPDPNFKSCTPYEL----RTI 372 D ++ + + LT + A +HP V + C R Sbjct: 207 ITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS 266 Query: 373 DVFDGNSGKMMCQLYDPESSGISSLN--EFNPMGDTLASAMGYHILIW 418 +F+ + S ISS++ +F+ G + + + +W Sbjct: 267 KLFEEPEDPSNRSFF---SEIISSISDVKFSHSGRYMMTRDYLSVKVW 311 >5AMS-A nrPDB Length = 431 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 55/186 (29%), Gaps = 11/186 (5%) Query: 152 GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA 211 S+ + +P N + L + + S ++ Sbjct: 61 FDKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 Query: 212 SSRMVVTGDNVGNVIL-LNMDGKELWNLRMHKKKVTHVAL---NPCCDWFLATASVDQTV 267 +VT D G V++ + G W L ++V + +P A + D +V Sbjct: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 Query: 268 KIWDLRQVRGKASFLYS-LPHRHPVNAACFSP-----DGARLLTTDQKSEIRVYSASQWD 321 + + + G L S H+ + F + L+T S I ++ Sbjct: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 Query: 322 CPLGLI 327 + Sbjct: 240 QLFKIT 245 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 79/239 (33%), Gaps = 33/239 (13%) Query: 117 LAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG--AGGSITGLKF----NPLNTN 170 L HPT T A G+ G + + +D G + +F NT Sbjct: 160 LKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 Query: 171 QFYASSMEGTTRLQD-FKGNILRVFASSDT--INIWFCSLDVSA------SSRMVVTGDN 221 + S++ T + F G L ++ + + SL ++ +S +V G N Sbjct: 220 ELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSN 279 Query: 222 VGNVILLNM-DGKELWNLRM----------HKKKVTHVALNPCCDWFLATASVDQTVKIW 270 G + ++N +G + +L + ++ + +A V + ++ Sbjct: 280 NGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFS-LMAIGLVCGEILLY 338 Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 329 D R + F+ V F D L + ++ ++A + H Sbjct: 339 DTSAWRVRHKFVL----EDSVTKLMFDNDD--LFASCINGKVYQFNARTGQEKFVCVGH 391 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/199 (15%), Positives = 58/199 (29%), Gaps = 24/199 (12%) Query: 229 NMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PH 287 +M L H V + +P T D +W F +L + Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVC-TGGGDNLAHLW--TSHSQPPKFAGTLTGY 108 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVY----SASQWDCPLGLIPHPHRHFQHLTPIKAA 343 V + F+ +G L+T D ++ V+ +QW + + P A Sbjct: 109 GESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR 168 Query: 344 WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPM 403 D + E DG+ ++M + + + Sbjct: 169 TFAFGA-------TDGSVWCYQINEQ------DGSLEQLMSGFVHQQDCSMGEFINTDKG 215 Query: 404 GDTL---ASAMGYHILIWS 419 +TL ++ I+ W+ Sbjct: 216 ENTLELVTCSLDSTIVAWN 234 >4J0X-A nrPDB Length = 451 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 65/211 (30%), Gaps = 11/211 (5%) Query: 195 ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG---KELWNLRMHKKKVTHVALN 251 +++ ++ S + VVTG +I+ + + ++ + + +V +A Sbjct: 108 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 167 Query: 252 PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE 311 D A+ + D ++ + + Q + H V + + Sbjct: 168 KNSDQLYASCA-DFKIRTYSINQF---SQLEILYGHHDIVEDISALAMERCVTVGARDRT 223 Query: 312 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 371 ++ L Q L + + +YPD + ++ + + Sbjct: 224 AMLWKIPDE---TRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDES-EAPLFFCEGS 279 Query: 372 IDVFDGNSGKMMCQLYDPESSGISSLNEFNP 402 IDV D + + SL + P Sbjct: 280 IDVVSMVDDFHFITGSDNGNICLWSLAKKKP 310 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 90/304 (29%), Gaps = 48/304 (15%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFN 165 +D ++A P V G + +++W+ I G + L F Sbjct: 110 TEGHYD-EILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 167 Query: 166 PLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 N++Q YAS + R + + L + I +L + R V G Sbjct: 168 K-NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAME---RCVTVGARDRT 223 Query: 225 VILLNMDGKELWNLRMHKKKVTHVA-LNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 +L + + R + + A D VK D +A + Sbjct: 224 AMLWKIPDETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPD----ESEAPLFF 275 Query: 284 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPHPH------ 331 V+ D +T I ++S + G++P P Sbjct: 276 CEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISG 331 Query: 332 --------RHFQHLTPIKAAW------HPRYNLIVVGRYPDPNFKSCTPYE-LRTIDVFD 376 R Q ++ W P N+ + G + + K + LR+ ++ Sbjct: 332 ETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWS-GSLKVWKISDNLRSFELLG 390 Query: 377 GNSG 380 SG Sbjct: 391 ELSG 394 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 42/111 (37%), Gaps = 3/111 (2%) Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 + H ++ VA +P + + T D+ + +W + + + R Sbjct: 103 KHEYENTTEGHYDEILTVAASPDGKY-VVTGGRDRKLIVWSTESLSPV-KVIPTKDRRGE 160 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 V + F + +L + +IR YS +Q+ L H H + ++ + Sbjct: 161 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGH-HDIVEDISALA 210 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 52/154 (33%), Gaps = 26/154 (16%) Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK 187 GS G+I LW+ K KP F + I G P + + + R + + Sbjct: 292 ITGSDNGNICLWSLA-KKKPIFTERIAHG-------ILPEPSFNDISGETDEELRKRQLQ 343 Query: 188 GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG-----KELWNLRMHK 242 G L W SL S + ++G G++ + + + L L K Sbjct: 344 GKKLLQ-------PFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAK 396 Query: 243 KKVTHVALNPCCDW------FLATASVDQTVKIW 270 VT + + LA+ + + + W Sbjct: 397 GVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 >5WLC-SG nrPDB Length = 573 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 65/211 (30%), Gaps = 11/211 (5%) Query: 195 ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG---KELWNLRMHKKKVTHVALN 251 +++ ++ S + VVTG +I+ + + ++ + + +V +A Sbjct: 230 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 289 Query: 252 PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE 311 D A+ + D ++ + + Q + H V + + Sbjct: 290 KNSDQLYASCA-DFKIRTYSINQF---SQLEILYGHHDIVEDISALAMERCVTVGARDRT 345 Query: 312 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 371 ++ L Q L + + +YPD + ++ + + Sbjct: 346 AMLWKIPDE---TRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDES-EAPLFFCEGS 401 Query: 372 IDVFDGNSGKMMCQLYDPESSGISSLNEFNP 402 IDV D + + SL + P Sbjct: 402 IDVVSMVDDFHFITGSDNGNICLWSLAKKKP 432 Score = 51.8 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 90/304 (29%), Gaps = 48/304 (15%) Query: 106 KAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFN 165 +D ++A P V G + +++W+ I G + L F Sbjct: 232 TEGHYD-EILTVAASPD-GKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR 289 Query: 166 PLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 224 N++Q YAS + R + + L + I +L + R V G Sbjct: 290 K-NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAME---RCVTVGARDRT 345 Query: 225 VILLNMDGKELWNLRMHKKKVTHVA-LNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY 283 +L + + R + + A D VK D +A + Sbjct: 346 AMLWKIPDETRLTFRGGDEPQKLLRRWMKEN----AKEGEDGEVKYPD----ESEAPLFF 397 Query: 284 SLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSAS------QWDCPLGLIPHPH------ 331 V+ D +T I ++S + G++P P Sbjct: 398 CEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISG 453 Query: 332 --------RHFQHLTPIKAAW------HPRYNLIVVGRYPDPNFKSCTPYE-LRTIDVFD 376 R Q ++ W P N+ + G + + K + LR+ ++ Sbjct: 454 ETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWS-GSLKVWKISDNLRSFELLG 512 Query: 377 GNSG 380 SG Sbjct: 513 ELSG 516 Score = 47.9 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 42/111 (37%), Gaps = 3/111 (2%) Query: 231 DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 + H ++ VA +P + + T D+ + +W + + + R Sbjct: 225 KHEYENTTEGHYDEILTVAASPDGKY-VVTGGRDRKLIVWSTESLSPV-KVIPTKDRRGE 282 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIK 341 V + F + +L + +IR YS +Q+ L H H + ++ + Sbjct: 283 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGH-HDIVEDISALA 332 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 52/154 (33%), Gaps = 26/154 (16%) Query: 128 AVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK 187 GS G+I LW+ K KP F + I G P + + + R + + Sbjct: 414 ITGSDNGNICLWSLA-KKKPIFTERIAHG-------ILPEPSFNDISGETDEELRKRQLQ 465 Query: 188 GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG-----KELWNLRMHK 242 G L W SL S + ++G G++ + + + L L K Sbjct: 466 GKKLLQ-------PFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAK 518 Query: 243 KKVTHVALNPCCDW------FLATASVDQTVKIW 270 VT + + LA+ + + + W Sbjct: 519 GVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 >5TF2-A nrPDB Length = 407 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 25/111 (22%), Positives = 39/111 (35%), Gaps = 13/111 (11%) Query: 248 VALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD 307 V N + LAT D V++W + + L H + PDG L+T Sbjct: 178 VCFN-HDNTLLATGGTDGYVRVWKVPSLE---KVLEFKAHEGEIEDLALGPDGK-LVTVG 232 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 + + V+ Q H+Q P ++ RY G+ PD Sbjct: 233 RDLKASVWQKDQ--------LVTQLHWQENGPTFSSTPYRYQACRFGQVPD 275 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 44/126 (34%), Gaps = 18/126 (14%) Query: 185 DFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG-KELWNLRMHKK 243 + + L+ + + + + + + ++ TG G V + + +++ + H+ Sbjct: 156 ELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEG 215 Query: 244 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 ++ +AL P L T D +W Q+ V + +G Sbjct: 216 EIEDLALGPDGK--LVTVGRDLKASVWQKDQL---------------VTQLHWQENGPTF 258 Query: 304 LTTDQK 309 +T + Sbjct: 259 SSTPYR 264 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 34/114 (29%), Gaps = 9/114 (7%) Query: 294 ACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVV 353 CF+ D L T +RV+ + L H A P L+ V Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEI------EDLALGPDGKLVTV 231 Query: 354 GRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTL 407 GR D +L T + N Y ++ + + P G L Sbjct: 232 GR--DLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPD-QPAGLRL 282 >2I3T-A nrPDB Length = 341 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 83/254 (32%), Gaps = 29/254 (11%) Query: 126 TVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQD 185 + VG+ G+I+ + P+F ++ + ++ A+S +G + D Sbjct: 71 QIYVGTVQGEIL--KVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVID 128 Query: 186 FKGNILRVFA----SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM----DGKELWN 237 + V A +S+ + + +S ++ G N V + D Sbjct: 129 PRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIE 188 Query: 238 LRMHKKKVTHVALNPCCDWFLATASVDQTVKI--WDLR----------QVRGKASFLYSL 285 K ++ VAL P A +S+D V + +D + R L Sbjct: 189 ESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDT 248 Query: 286 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 345 +PVN+ FSP L T I ++ F + +K A Sbjct: 249 NLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFA-----KFNEDSVVKIA-- 301 Query: 346 PRYNLIVVGRYPDP 359 N++ + D Sbjct: 302 CSDNILCLATSDDT 315 >5AJA-A nrPDB Length = 361 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 73/225 (32%), Gaps = 37/225 (16%) Query: 191 LRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM-DGKELWNLRMHKKKVTHVA 249 + VF ++ F SA R ++ G G + L N+ G+E + H +TH+ Sbjct: 27 ISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLE 86 Query: 250 LNPCCDWFLATASVDQTV-KIWDLRQVRGKASFLYSLPHR-HPVNAACFSPDGARLLTTD 307 + L +A+ Q + +W ++ ++ + H + FS + Sbjct: 87 PSRDGSLLLTSATWSQPLSALWGMKS-------VFDMKHSFTEDHYVEFSKHSQDRVIGT 139 Query: 308 QKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 + +Y + L L +P A + + N D + Sbjct: 140 KGDIAHIYDIQTGNKLLTL-FNPD----------LANNYKRNCATFNPTDDLVLNDGVLW 188 Query: 368 ELRT------IDVFDGNSGKMMCQLYDPES------SGISSLNEF 400 ++R+ D F+ N + P + I L F Sbjct: 189 DVRSAQAIHKFDKFNMNISGVFH----PNGLEVIINTEIWDLRTF 229 >4AV8-A nrPDB Length = 339 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 37/125 (29%), Gaps = 19/125 (15%) Query: 271 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE-IRVYSASQWDCPLGLIPH 329 D QV GK + H +PV + G + T Q IRV+ L+ Sbjct: 164 DAEQVVGKGVLVK--AHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNG----VLVRE 217 Query: 330 PHRHFQHLTPIKAAWHPRYNLIVVGR----------YPDPNFKSCTPYELRTIDVFDGNS 379 R + I W P + + V + D K + I F Sbjct: 218 FRRGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSE- 276 Query: 380 GKMMC 384 +C Sbjct: 277 -WSIC 280 >6IYY-A nrPDB Length = 317 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 72/196 (36%), Gaps = 14/196 (7%) Query: 129 VGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKG 188 VG +M+W+ K I+ + +K + ++ ++ F Sbjct: 66 VGGGKKKVMIWDDLKKKTVIEIEF---STEVKAVKLR-RDRIVVV---LDSMIKVFTFTH 118 Query: 189 NILRVFASSDTINIWFCSLDVSASSRMVVT--GDNVGNVILLNMDGKEL--WNLRMHKKK 244 N ++ N + S+ ++ G + G+V L+++ E ++ H+ Sbjct: 119 NPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGV 178 Query: 245 VTHVALNPCCDWFLATASVDQT-VKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 303 ++ +ALN +ATAS T ++I+D L + F+ D + + Sbjct: 179 LSCIALNLQGTR-IATASEKGTLIRIFDTSSGHL-IQELRRGSQAANIYCINFNQDASLI 236 Query: 304 LTTDQKSEIRVYSASQ 319 + + +++A Sbjct: 237 CVSSDHGTVHIFAAED 252 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 27/187 (14%), Positives = 49/187 (26%), Gaps = 29/187 (15%) Query: 241 HKKKVTHVALNP----------CCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP 290 H+ V NP + V++ DL + H Sbjct: 121 HQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIP--AHEGV 178 Query: 291 VNAACFSPDGARLLTTDQKSE-IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 ++ + G R+ T +K IR++ S L R I + Sbjct: 179 LSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQEL-----RRGSQAANIYCINFNQDA 233 Query: 350 LIVVGRYPDPNFKSC---TPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNE------- 399 ++ P + F SG + E + + ++ Sbjct: 234 SLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKF 293 Query: 400 -FNPMGD 405 FNP G+ Sbjct: 294 LFNPKGE 300 >3DWL-C nrPDB Length = 377 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 69/227 (30%), Gaps = 19/227 (8%) Query: 198 DTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDG---KELWNLRMHKKKVTHVALNPCC 254 + ++ VT V L DG K H K VT V P Sbjct: 8 HILPKPSYEHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKS 67 Query: 255 DWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRV 314 + + T S D+ +++ R L L +SP+ + I V Sbjct: 68 NR-IVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISV 126 Query: 315 YSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYEL-RTID 373 + + + H R + + WHP L+ G K+ R +D Sbjct: 127 -CYFEQENDWWVSKHLKRPLRSTI-LSLDWHPNNVLLAAGCAD---RKAYVLSAYVRDVD 181 Query: 374 VFDGNSGK-------MMCQLYDPESSGISSLNEFNPMGDTLASAMGY 413 S +C Y P + ++ F+P G+ LA A Sbjct: 182 AKPEASVWGSRLPFNTVCAEY-PSGGWVHAVG-FSPSGNALAYAGHD 226 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 43/132 (32%), Gaps = 21/132 (15%) Query: 287 HRHPVNAACFSPDGARLLTTDQKSEIRVYSA---SQWDCPLGLIPHPHRHFQHLTPIKAA 343 H V ++P R++T Q VY W L L +R Sbjct: 54 HDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVL-LRLNR-----AATFVR 107 Query: 344 WHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQ-LYDPESSGISSLNEFNP 402 W P + VG + ++ F+ + + + L P S I SL+ ++P Sbjct: 108 WSPNEDKFAVGS----------GARVISVCYFEQENDWWVSKHLKRPLRSTILSLD-WHP 156 Query: 403 MGDTLASAMGYH 414 LA+ Sbjct: 157 NNVLLAAGCADR 168 >6CVZ-A nrPDB Length = 351 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 45/114 (39%), Gaps = 12/114 (10%) Query: 155 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 214 G I GL F+ ++S++ T +L + N + V + +W C + + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTV-VQTYNAGRPVWSCCWCLD-EAN 130 Query: 215 MVVTGDNVGNVILLNMDG-----KELWNLRMHKKKVTHVALNPCCDWFLATASV 263 + G G++++ ++ +EL + + ++ P A+A+ Sbjct: 131 YIYAGLANGSILVYDVRNTSSHVQELVAQKARC-PLVSLSYMPRA----ASAAF 179 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 41/235 (17%), Positives = 73/235 (31%), Gaps = 29/235 (12%) Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASV 263 L +S S G +L + K + MH K++ +A + L +AS+ Sbjct: 36 LSCLVISQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASL 95 Query: 264 DQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPD-GARLLTTDQKSEIRVYSASQ--- 319 D T+K+ L + + + PV + C+ D + I VY Sbjct: 96 DNTIKLTSLET----NTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSS 151 Query: 320 --WDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNF--KSCTPYELR----- 370 + P ++ +A P ++ G D +F + Sbjct: 152 HVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLA-GTLEDASFWEQKMDFSHWPHVLPL 210 Query: 371 ----TIDVFDGNSGKMMCQLY--DPESSGISSL-----NEFNPMGDTLASAMGYH 414 ID NS + Y D + I S+ + G+ + S H Sbjct: 211 EPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVH 265 >2VDU-B nrPDB Length = 450 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 74/216 (34%), Gaps = 9/216 (4%) Query: 29 ELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQ 88 E E E KKL + +R + GL P I R++ T + +L A S + Sbjct: 68 ENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYIRNLRLTSDESRL-IACADSDKS 126 Query: 89 GLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGI--KDK 146 L T + L+K F +R +++ +TV + K GD+ + ++K Sbjct: 127 LLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDD-TTVIIADKFGDVYSIDINSIPEEK 185 Query: 147 PTFIKGIGAGGSITGLKFNPLNTNQ--FYASSMEGTTRLQDF-KGNILRVFASSDTINIW 203 T +G +T + + S + ++ + + I+ + + Sbjct: 186 FTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHK--HF 243 Query: 204 FCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLR 239 S+ ++ G + GK L Sbjct: 244 VSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 >5WLC-LH nrPDB Length = 896 Score = 44.5 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 65/189 (34%), Gaps = 28/189 (14%) Query: 96 HTLDSYRILQKAAPFDRR------ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTF 149 ++L SYR+ A FD A WH S + S G + + K Sbjct: 166 NSLQSYRL--YALTFDDAKKQFEVAHQAEWHNVILSNI--SSNGKLLAHMCKDVSTKDHE 221 Query: 150 IKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDV 209 K SI+ + + N + +++ Q N + S+ + Sbjct: 222 HK------SISVVSLFDDSVNLSFPLGSILSSQTQSLSYNT-----------RYVSSMAI 264 Query: 210 SASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKI 269 + + G G + ++++ ++ L+ H V ++ + + L + ++ + + Sbjct: 265 DNMGQQLAVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLL-SGGWEKVMSL 323 Query: 270 WDLRQVRGK 278 W L + Sbjct: 324 WQLETNSQQ 332 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 43/126 (34%), Gaps = 13/126 (10%) Query: 204 FCSLDVSAS----SRMVVTGDNVGNVILLNMDGKELWN----LRMHKKKVTHVALNPCCD 255 DVS + V +V L G L + L + + V+ +A++ Sbjct: 210 HMCKDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAID-NMG 268 Query: 256 WFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 315 LA + I L ++ + H V + FS DG+ LL+ + + ++ Sbjct: 269 QQLAVGFASGVISIVSLADLQIRLLKW----HIDSVLSLSFSHDGSYLLSGGWEKVMSLW 324 Query: 316 SASQWD 321 Sbjct: 325 QLETNS 330 >5WLC-LS nrPDB Length = 594 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 24/153 (15%), Positives = 55/153 (35%), Gaps = 11/153 (7%) Query: 179 GTTRLQ-DFKGNILRVFASSDTINIWFCSLDVSA--SSRMVVTGDNVGNVILLN----MD 231 R D G + +L +S +R + G G V L + M Sbjct: 442 HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMT 501 Query: 232 GKE---LWNLRMHKKKVTHVALNPCCDWF-LATASVDQTVKIWDLRQVRGKASFLYSLPH 287 + L ++++ +P +A+ +V +++ L +++ S Sbjct: 502 SSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTP 561 Query: 288 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQW 320 V + FSP G L +++ ++R++ + + Sbjct: 562 LGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY 594 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 34/99 (34%), Gaps = 7/99 (7%) Query: 195 ASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGK---ELWNLRMHKKKVTHVAL- 250 +S + SL S +++TG + + ++DGK + +L + + Sbjct: 242 NASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFY 301 Query: 251 ---NPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 286 + + TA + + WDL S + Sbjct: 302 TSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIE 340 Score = 34.4 bits (77), Expect = 0.093, Method: Composition-based stats. Identities = 48/357 (13%), Positives = 89/357 (24%), Gaps = 58/357 (16%) Query: 109 PFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNP-- 166 P SL++HP+ P + G + +++ K G I F Sbjct: 246 PSHSAIQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSL 304 Query: 167 --LNTNQFYASSMEGTTRLQDFKGNILR-----------VFASSDTINIWFCSLDV---- 209 N + + D L ++ F + V Sbjct: 305 SNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQ 364 Query: 210 -----SASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVT--HVALNPCCD-----WF 257 S +++ G+N IL + G L ++ + +T + P Sbjct: 365 NSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKI-EGVITDFCIDYQPISRGKFRTIL 423 Query: 258 LATAS------VD-----QTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP--DGARLL 304 +A + D ++ W + G A S L Sbjct: 424 IAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLA 483 Query: 305 TTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI-VVGRYPDPNFKS 363 + + +Y + P T + P ++ + R + Sbjct: 484 VGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALR- 542 Query: 364 CTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY-HILIWS 419 L + VF P S F+P G LA + +W Sbjct: 543 --LVHLPSCSVFSN-----WPTSGTPLGKVTSV--AFSPSGGLLAVGNEQGKVRLWK 590 >5LTD-A nrPDB Length = 525 Score = 41.4 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 73/216 (33%), Gaps = 36/216 (16%) Query: 136 IMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFA 195 + + N + + G +I +K N +E T + D N +R+ Sbjct: 101 LKIINTKRQTTICELTFPG---AILAVKLNRERLVVL----LEETIYIYDI--NNMRLLH 151 Query: 196 SSDTINIWFCSLDVSASSR--MVVTGD---------------------NVGNVILLNMDG 232 + +T + + +S SS + G+VI+ + Sbjct: 152 TIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKT 211 Query: 233 -KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTV-KIWDLRQVRGKASFLYSLPHRHP 290 + + H+ + +AL+ LATAS T+ +++ + K + Sbjct: 212 LQPTSVIEAHRTSLAAIALSKDG-LLLATASDKGTIIRVFSVATG-IKLYQFRRGTYPTK 269 Query: 291 VNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGL 326 + + FSPD ++ + + ++ + + + Sbjct: 270 IYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTI 305 >6N8P-A nrPDB Length = 979 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 97/331 (29%), Gaps = 52/331 (15%) Query: 110 FDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNT 169 F + ++L + P+ +A+G++ G I L+ F+ ++T + P Sbjct: 20 FPHQPSALGYSPSL-RILAIGTRSGAIKLYGAP---GVEFMGLHQENNAVTQIHLLP-GQ 74 Query: 170 NQFYASSMEGTTRLQDFKG-------NILRVFASSDTINIWFCSLDVS-----ASSRMVV 217 Q + + L K F + ++ +S ++ Sbjct: 75 CQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLY 134 Query: 218 TGDNVGNVILLNMDG---------------KELWNLRMHKK---KVTHVALNPCCDWFLA 259 G GNV ++ + + L H++ V + +P + Sbjct: 135 LGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQIL 194 Query: 260 TASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 319 V IWDL+ R FL S + + DG L++ + S Sbjct: 195 IGYSRGLVVIWDLQGSRVLYHFLSSQQLEN----IWWQRDGRLLVSCHSDGSYCQWPVSS 250 Query: 320 WDCPLGLIPHPHRHFQHLTPIKA------AWHPRYNLIVVGRYPDPNFKSCTPYELRTID 373 P P R P W + + ++ + + I Sbjct: 251 EAQ----QPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRA-SYGDRHCIS 305 Query: 374 VFDGNSGKMMCQLYDPESSGISSLNEFNPMG 404 V + G+ + G + L E +P Sbjct: 306 VI--HDGQQTAFDFTSRVIGFTVLTEADPAA 334 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 23/77 (29%), Gaps = 4/77 (5%) Query: 136 IMLWNFGIKDKPT----FIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNIL 191 + LW I F T L P + +GT R D G L Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCL 446 Query: 192 RVFASSDTINIWFCSLD 208 R+ T+ ++ D Sbjct: 447 RLLYKLSTVRVFLTDTD 463 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 19/62 (30%), Gaps = 15/62 (24%) Query: 214 RMVVTGDNVGNV---ILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270 R++ G + +DG T + P L T D TV+ W Sbjct: 392 RIIAAGSRQNAHFSTMEWPIDGG------------TSLTPAPPQRDLLLTGHEDGTVRFW 439 Query: 271 DL 272 D Sbjct: 440 DA 441 >5BPT-A nrPDB Length = 741 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 14/92 (15%), Positives = 31/92 (33%), Gaps = 5/92 (5%) Query: 285 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAW 344 LPH + +SP + ++ E+ ++ + L P+ + + AW Sbjct: 12 LPH--EIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVT---CLAW 66 Query: 345 HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFD 376 P ++ G C + ++ F Sbjct: 67 RPDGKILAFGLADTKKVILCDVEKPESLHSFS 98 >2XE4-A nrPDB Length = 751 Score = 36.4 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 27/210 (12%), Positives = 56/210 (26%), Gaps = 22/210 (10%) Query: 107 AAPFDRRATSLAWHPTHPSTVAVGSKGGDI---MLWNFGIKDKPT--FIKGIGAGGSITG 161 A + W P H S V +K + +W + + + Sbjct: 216 ADKVSGTNGEIVWGPDHTSLFYV-TKDETLRENKVWRHVMGKLQSEDVCLYEEHNPLFSA 274 Query: 162 LKFNPLNTNQFYASSME---GTTRLQDFKGNILRV---FASSDTINIWFCSLDVSASSRM 215 + +TN S L D + + + S + Sbjct: 275 FMYKAADTNTLCIGSQSPETAEVHLLDLRKGNAHNTLEIVRPREKGVRYDVQMHGTSHLV 334 Query: 216 VVT--GDNVGNVILLNMDGKELW---NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 270 ++T G V + +L+ G+ L H + V ++ ++ + +IW Sbjct: 335 ILTNEGGAVNHKLLIAPRGQPSDWSHVLVDHSEDVFMESIAVRSNYLVVAGRRAGLTRIW 394 Query: 271 DLRQVRGKASF-----LYSLPHRHPVNAAC 295 + F L + P+ Sbjct: 395 TMMADSQDGVFKAGTGLREVVMEEPIFTVH 424 >4YHC-A nrPDB Length = 468 Score = 35.6 bits (80), Expect = 0.042, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 59/162 (36%), Gaps = 23/162 (14%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP--VNAACFSP 298 H+ + +A++ F A+ +D+++ +WDLRQ K + P + A P Sbjct: 29 HQLDILKIAVSENYKTF-ASVGLDRSLVVWDLRQWCTKLVLSKE---QMPRTLKAIALDP 84 Query: 299 DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 G + + + + + L+ H + + + W P G + D Sbjct: 85 QGNYVSLFSKD-TLFILNVES----PSLMLQHSYHSKPNSKLNVFWMP-------GTHKD 132 Query: 359 PNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 +EL ++ ++ + E + I+ + +F Sbjct: 133 DE---WKNFELVVVE--SSGEIQVFSLTIEIEGADIALVEKF 169 >6NAU-A nrPDB Length = 334 Score = 35.2 bits (79), Expect = 0.051, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 65/202 (32%), Gaps = 20/202 (9%) Query: 146 KPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEG----TTRLQDFKGNILRVFASSDTIN 201 PT I G + +N +G T + + S D Sbjct: 86 SPTHISTDRHGRFVFSASYNQG--CVSVTPLHDGLPGETITVVEGLEGCHSANISPDNRT 143 Query: 202 IWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATA 261 +W +L + + L + E+ + H+ +P + Sbjct: 144 LWVPAL----KQDRICLFTLSDDGFLSAQEPAEVTTVEG--AGPRHMVFHPNQQYGYCVN 197 Query: 262 SVDQTVKIWDLRQVRGKASFLYSLPHRHP-VNAACF------SPDGARLLTTDQKSE-IR 313 ++ ++ +W+L+ +G + +L P + + +PDG L D+ + I Sbjct: 198 ELNSSIDVWELKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDGRHLYACDRTASIIT 257 Query: 314 VYSASQWDCPLGLIPHPHRHFQ 335 V+S S+ L + + Q Sbjct: 258 VFSVSEDGSVLAVEGYQPTETQ 279 >4CAB-A nrPDB Length = 536 Score = 34.4 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 28/113 (24%), Positives = 44/113 (38%), Gaps = 20/113 (17%) Query: 97 TLDSYRILQKAAPFDR-----RATSLAWHPTHPSTVAVG-------SKGGDIMLWNFGIK 144 TL++Y+ ++K + FDR R H A G SK L+ K Sbjct: 57 TLENYQFIEKLSHFDRERIPERVVHARGVGAHGVFRATGKVGDEPVSKYTRAKLFQEDGK 116 Query: 145 DKPTFIKG--IGAGGSITGLKFNPLN-TNQFYASSMEGTTRLQDFKGNILRVF 194 + P F++ +G G +P +FY +G D GN L++F Sbjct: 117 ETPVFVRFSTVGHGTHSPETLRDPRGFAVKFYT--EDGN---WDLVGNNLKIF 164 >5GRS-A nrPDB Length = 396 Score = 34.1 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 58/162 (35%), Gaps = 23/162 (14%) Query: 241 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHP--VNAACFSP 298 H+ + +A++ F A+ +D+ + +WDLRQ K + P + A P Sbjct: 29 HQLDILKIAVSENYKTF-ASVGLDRCLVVWDLRQWCTKLVLSKE---QMPRTLKAIALDP 84 Query: 299 DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 358 G + + + + + L+ H + + + W P G + D Sbjct: 85 QGNYVSLFSKD-TLFILNVES----PSLMLQHSYHCKPNSKLNVFWMP-------GTHKD 132 Query: 359 PNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF 400 +EL ++ ++ + E + I+ + +F Sbjct: 133 DE---WKNFELVVVE--SSGEIQVFSLTIEIEGADIALVEKF 169 >1XFD-A nrPDB Length = 723 Score = 33.3 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 24/179 (13%), Positives = 50/179 (27%), Gaps = 29/179 (16%) Query: 170 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCS-LDVSASSRMVVTGDNVGNVILL 228 +F +GT RL + + N V I ++S + NV + Sbjct: 28 TEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQH 87 Query: 229 NMDGKELWNLRMHKKK------------VTHVALNP----------CCDWFLATASVDQT 266 + G + + H + + P ++ A Q Sbjct: 88 SYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGK-QA 146 Query: 267 VKIWDLRQVRGKASFLYSLPHRHPVNAAC----FSPDGARLLTTD-QKSEIRVYSASQW 320 +++ + + L + + +SPDG RL S + + + Sbjct: 147 IRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTY 205 >1C5K-A nrPDB Length = 439 Score = 33.3 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 19/141 (13%), Positives = 38/141 (26%), Gaps = 14/141 (9%) Query: 219 GDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 278 G + + + DG + + + + A +P + G Sbjct: 177 GQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGA 236 Query: 279 ASFLYSLP-HRHPVNAACFSPDGARLLTT-DQKSEIRVY--SASQWDCPLGLIPHPHRHF 334 + S P H A FSPDG++L + + +Y + + Sbjct: 237 VRQVASFPRHNG---APAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNN-- 291 Query: 335 QHLTPIKAAWHPRYNLIVVGR 355 + W P + Sbjct: 292 -----TEPTWFPDSQNLAFTS 307 >5BPW-A nrPDB Length = 843 Score = 33.3 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 10/87 (11%), Positives = 26/87 (29%), Gaps = 3/87 (3%) Query: 290 PVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYN 349 + +SP + + E+ ++ + + P+ + + AW P Sbjct: 22 EIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVT---CLAWRPDGK 78 Query: 350 LIVVGRYPDPNFKSCTPYELRTIDVFD 376 L+ C + ++ F Sbjct: 79 LLAFALADTKKIVLCDVEKPESLHSFS 105 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 36/92 (39%), Gaps = 10/92 (10%) Query: 210 SASSRMVVTGDNVGNVILLNMDG-KELWNL---RMHKKKVTHVALNPCCDWFLATASVD- 264 S ++ + G V+L + +W+ K+VT +A P LA A D Sbjct: 29 SPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGK-LLAFALADT 87 Query: 265 QTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 296 + + + D+ K L+S PV+ + Sbjct: 88 KKIVLCDVE----KPESLHSFSVEAPVSCMHW 115 Score = 31.7 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 30/101 (29%), Gaps = 2/101 (1%) Query: 243 KKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGAR 302 +++ + +P D +A A+ V + L SF + V + PDG Sbjct: 21 QEIIFLVWSPKRD-LIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKL 79 Query: 303 LLTTDQK-SEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA 342 L +I + + + H + Sbjct: 80 LAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV 120 >4R40-A nrPDB Length = 411 Score = 32.9 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 18/154 (11%), Positives = 42/154 (27%), Gaps = 16/154 (10%) Query: 219 GDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCD--WFLATASVDQTVKIWDLRQVR 276 G + + + DG + + + + A +P ++ S + I L Sbjct: 157 GKFPHELRVSDYDGYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGA 216 Query: 277 GKASFLYSLPHRHPVNAACFSPDGARLLTT-DQKSEIRVY--SASQWDCPLGLIPHPHRH 333 + + + P FSPDG +L + + +Y + + Sbjct: 217 IRQVASFPRHNGAP----AFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNN- 271 Query: 334 FQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPY 367 + +W P + + Sbjct: 272 ------TEPSWFPDSQNLAYTSDQGGRPQVYKVN 299 >1RI6-A nrPDB Length = 343 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 26/222 (11%), Positives = 57/222 (25%), Gaps = 19/222 (8%) Query: 169 TNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTG---DNVGNV 225 + AS + + + + VS R + G + Sbjct: 5 QTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLA 64 Query: 226 ILLNMDGKELW--NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVR--GKASF 281 + D L +TH++ + + + V + L G Sbjct: 65 YRIAPDDGALTFAAESALPGSLTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDV 124 Query: 282 LYSLP--HRHPVNAACFSPDGARL-LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 338 + L H + SPD L + ++ I +++ S + P + Sbjct: 125 VEGLDGCHSANI-----SPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAG 179 Query: 339 PIKAAWHPRYNLIVVGRYPDPNFKSCTPYE----LRTIDVFD 376 P +HP + + + + + D Sbjct: 180 PRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLD 221 >5CWW-B nrPDB Length = 595 Score = 32.1 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 52/185 (28%), Gaps = 31/185 (16%) Query: 243 KKVTHVALNPCCDWFLATASVDQTVKIW---------DLRQVRGKASFLYSLPH---RHP 290 + + ++P D+ S + I D + K L H R Sbjct: 115 DDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSA 174 Query: 291 VNAACFSP---DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 347 V +A + P +G L+T + + +RV+ S D P + Sbjct: 175 VVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWTFDAPTLAIDLKK----------- 223 Query: 348 YNLIVVGRYPDPNFKSCTPYELRTI--DVFDGNSGKMMCQLYDPESSGISSLNEFNPMGD 405 + Y D +F T + D FD D +L GD Sbjct: 224 ---LADATYLDQDFGVSTSATNKGFSPDAFDMEVAAACFPTRDSGGWAPMTLWLAMTSGD 280 Query: 406 TLASA 410 A Sbjct: 281 VYALC 285 >1CII-A nrPDB Length = 602 Score = 31.4 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 17/98 (17%), Positives = 38/98 (38%), Gaps = 5/98 (5%) Query: 251 NPCCDWFLATAS--VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQ 308 + D + + T+KI + +A+ Y L H D ++T D Sbjct: 278 SSTNDSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLSHSGLDYKRNILNDRNPVVTEDV 337 Query: 309 KSEIRVYSAS--QWDCPLG-LIPHPHRHFQHLTPIKAA 343 + + ++Y+A +WD L+ ++ + + +A Sbjct: 338 EGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSA 375 >3V91-A nrPDB Length = 291 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 39/91 (42%), Gaps = 7/91 (7%) Query: 80 RASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKG------ 133 + S+ QGL +F ++ + I +K PF +S++ + P+ A G+ Sbjct: 176 QGSFDGGDQGLLNTFFNSWATTDI-RKHLPFIYNLSSISIYSYLPAFKAFGANAKVVHFL 234 Query: 134 GDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 G WN+ K ++ G ++T +F Sbjct: 235 GQTKPWNYTYDTKTKSVRSEGHDPTMTHPQF 265 >1ZCU-A nrPDB Length = 353 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 39/91 (42%), Gaps = 7/91 (7%) Query: 80 RASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKG------ 133 + S+ QGL +F ++ + I +K PF +S++ + P+ A G+ Sbjct: 176 QGSFDGGSQGLLNTFFNSWATTDI-RKHLPFIYNLSSISIYSYLPAFKAFGANAKVVHFL 234 Query: 134 GDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 164 G WN+ K ++ G ++T +F Sbjct: 235 GQTKPWNYTYDTKTKSVRSEGHDPTMTHPQF 265 >4RS1-B nrPDB Length = 281 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 50/170 (29%), Gaps = 19/170 (11%) Query: 272 LRQVRGKASFLYSLPHRHPVNAACFS------------PDGARLLTTDQKSEIRVYSASQ 319 L +F H P+ R T Q +Y+A Sbjct: 40 LSNNECSCTFREICLHEGVTFEVHVQTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADL 99 Query: 320 WDCPLGLIPHPHRHFQHLTPIKAAWHPR-----YNLIVVGRYPDPNFKSCTPYELRTIDV 374 +C P R Q+ I+ + R Y + G + + + + R + Sbjct: 100 MNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFL 159 Query: 375 FDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILI-WSQEEA 423 +G S ++ Q +D + FNP + H L+ W Q Sbjct: 160 VNGTSREIGIQFFDSLLDT-KKIERFNPPSNVTVRCNTTHCLVRWKQPRT 208 >3I4X-A nrPDB Length = 465 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 29/76 (38%), Gaps = 5/76 (6%) Query: 81 ASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHP--STVAVGSKGGDIML 138 S + S + ++YR+L +A FD L WH T P + + + Sbjct: 1 GSHGGSMKAANAS---SAEAYRVLSRAFRFDNEDQKLWWHSTAPMFAKMLETANYTTPCQ 57 Query: 139 WNFGIKDKPTFIKGIG 154 + + I K I +G Sbjct: 58 YQYLITYKECVIPSLG 73 >2RD7-C nrPDB Length = 184 Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 9/47 (19%), Positives = 12/47 (25%), Gaps = 3/47 (6%) Query: 270 WDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTD---QKSEIR 313 W L V FL HR +P G + + Sbjct: 33 WLLVAVGSACRFLQEQGHRAEATTLHVAPQGTAMAVSTFRKLDGICW 79 >2ZZW-A nrPDB Length = 361 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 31/82 (37%), Gaps = 2/82 (2%) Query: 337 LTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 396 +P+ A RY + + + ++ T V + G++ Q + P + + + Sbjct: 23 FSPLAVAQARRYRWRIQTAWDAGTV-GYSLFQKFTERVKELTDGQLEVQPF-PAGAVVGT 80 Query: 397 LNEFNPMGDTLASAMGYHILIW 418 + F+ + + M L W Sbjct: 81 FDMFDAVKTGVLDGMNPFTLYW 102 >3DWO-X nrPDB Length = 451 Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 7/37 (18%), Positives = 12/37 (32%) Query: 237 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 273 L+ H + + W LA + W +R Sbjct: 318 TLKSHGNTIVSIPYTYRNTWTLAVGGDYKVTDQWTMR 354 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.305 0.119 0.299 Lambda K H 0.267 0.0365 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,552,039 Number of Sequences: 36641 Number of extensions: 534775 Number of successful extensions: 3927 Number of sequences better than 10.0: 159 Number of HSP's better than 10.0 without gapping: 170 Number of HSP's successfully gapped in prelim test: 79 Number of HSP's that attempted gapping in prelim test: 1450 Number of HSP's gapped (non-prelim): 772 length of query: 427 length of database: 10,336,785 effective HSP length: 100 effective length of query: 327 effective length of database: 6,672,685 effective search space: 2181967995 effective search space used: 2181967995 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.9 bits)