BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q8TD30 (523 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3IHJ-A nrPDB 992 0.0 3TCM-A nrPDB 426 e-120 1XI9-A nrPDB 142 4e-34 4CVQ-A nrPDB 127 1e-29 3PDX-A nrPDB 92 7e-19 1GDE-A nrPDB 86 5e-17 1J32-A nrPDB 83 3e-16 3DYD-A nrPDB 82 4e-16 1BW0-A nrPDB 82 8e-16 2Z61-A nrPDB 80 2e-15 5YHV-A nrPDB 78 9e-15 4IX8-A nrPDB 75 7e-14 1GC4-A nrPDB 72 4e-13 6F35-A nrPDB 71 1e-12 4MY5-A nrPDB 69 3e-12 1IAY-A nrPDB 65 6e-11 2GB3-A nrPDB 64 1e-10 5WMH-A nrPDB 64 2e-10 1O4S-A nrPDB 62 4e-10 2X5D-A nrPDB 60 2e-09 6F77-B nrPDB 59 4e-09 3OP7-A nrPDB 58 9e-09 1M4N-A nrPDB 57 2e-08 1V2E-A nrPDB 55 8e-08 3ASB-A nrPDB 52 5e-07 3H14-A nrPDB 52 7e-07 3QGU-A nrPDB 52 7e-07 3B1C-A nrPDB 50 2e-06 2O0R-A nrPDB 49 7e-06 3ELE-A nrPDB 47 3e-05 2ZY2-A nrPDB 46 3e-05 3B46-A nrPDB 45 5e-05 1IJI-A nrPDB 45 1e-04 3CQ5-A nrPDB 44 1e-04 3LY1-A nrPDB 43 3e-04 5Z0Q-C nrPDB 43 4e-04 2ZC0-A nrPDB 42 5e-04 1YIY-A nrPDB 39 0.004 3JTX-A nrPDB 39 0.005 2ZY3-A nrPDB 39 0.007 4WP0-A nrPDB 39 0.008 1U08-A nrPDB 38 0.009 3FVS-A nrPDB 38 0.010 1VP4-A nrPDB 37 0.019 3NRA-A nrPDB 37 0.019 2DOU-A nrPDB 37 0.028 3T32-A nrPDB 36 0.036 4M2J-A nrPDB 36 0.042 3EI8-A nrPDB 35 0.088 1C7O-A nrPDB 35 0.11 2ZJG-A nrPDB 34 0.14 3F6T-A nrPDB 34 0.16 3EUC-A nrPDB 34 0.18 3EZS-A nrPDB 33 0.27 1D2F-A nrPDB 33 0.36 4FL0-A nrPDB 33 0.39 3FTB-A nrPDB 32 0.49 4DQ6-A nrPDB 32 0.50 6HNV-A nrPDB 32 0.51 3FDB-A nrPDB 31 1.0 4PSP-A nrPDB 31 1.1 3P1T-A nrPDB 31 1.5 4RAE-A nrPDB 31 1.5 4RKC-A nrPDB 30 1.9 3DZZ-A nrPDB 30 2.4 3G7Q-A nrPDB 30 3.4 1UU1-A nrPDB 29 5.5 1J5Y-A nrPDB 29 6.1 1LC8-A nrPDB 29 6.1 4RNY-A nrPDB 28 8.8 >3IHJ-A nrPDB Length = 498 Score = 992 bits (2564), Expect = 0.0, Method: Compositional matrix adjust. Identities = 475/476 (99%), Positives = 476/476 (100%) Query: 48 LTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT 107 +TLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT Sbjct: 23 MTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT 82 Query: 108 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI 167 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI Sbjct: 83 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI 142 Query: 168 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD 227 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD Sbjct: 143 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD 202 Query: 228 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH Sbjct: 203 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 262 Query: 288 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 347 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC Sbjct: 263 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 322 Query: 348 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE 407 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE Sbjct: 323 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE 382 Query: 408 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 467 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC Sbjct: 383 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 442 Query: 468 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA 523 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA Sbjct: 443 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA 498 >3TCM-A nrPDB Length = 500 Score = 426 bits (1096), Expect = e-120, Method: Compositional matrix adjust. Identities = 212/482 (43%), Positives = 317/482 (65%), Gaps = 13/482 (2%) Query: 48 LTLESMNPQVKAVEYAVRGPIVLKAGEIE--LELQRGIKKPFTEVIRANIGDAQAMGQQP 105 + ++++NP+V EYAVRG IV+ A ++ L+ Q G PF E++ NIG+ Q++GQQP Sbjct: 23 VAVDNLNPKVLKCEYAVRGEIVIHAQRLQEQLKTQPG-SLPFDEILYCNIGNPQSLGQQP 81 Query: 106 ITFLRQVMALCTYPNLLDSPS----FPEDAKKRARRILQACGGNSLGSYSASQGVNCIRE 161 +TF R+V+ALC +P+LL F D+ RA++IL G + G+YS SQG++ +R+ Sbjct: 82 VTFFREVLALCDHPDLLQREEIKTLFSADSISRAKQILAMIPGRATGAYSHSQGIHGLRD 141 Query: 162 DVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSA 221 +A+ I RDG PA+ D+I+LT GAS G+ ++++L+ + G+++PIPQYPLYSA Sbjct: 142 AIASGIASRDG-FPANADDIFLTDGASPGVHLMMQLLIR---NEKDGILVPIPQYPLYSA 197 Query: 222 VISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDH-CDPKVLCIINPGNPTGQVQSRK 280 I+ V YYL+E W L +++++ +++A+ + + L +INPGNPTGQV + + Sbjct: 198 SIALHGGALVPYYLNESTGWGLETSDVKKQLEDARSRGINVRALVVINPGNPTGQVLAEE 257 Query: 281 CIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTS 340 D++ F E L LLADEVYQ+N+Y + +FHSFKK++ +G ++ L S+ S S Sbjct: 258 NQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKIVRSLGYG-EEDLPLVSYQSVS 316 Query: 341 KGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFE 400 KGY GECG RGGY E+ ++ Q+ K+ SV LC ++GQ +V+NPP A +ES+ Sbjct: 317 KGYYGECGKRGGYFEITGFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKASDESYA 376 Query: 401 QFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQM 460 + EK+ +L +LA++AK E FN++ GI CN +GAMY FP+I +P KA+EAA+A Sbjct: 377 SYKAEKDGILASLARRAKALEHAFNKLEGITCNEAEGAMYVFPQICLPQKAIEAAKAANK 436 Query: 461 APDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLE 520 APD FY ++LLE TGI VVPGSGFGQ GT+HFR TILP +K+ V+ + FH F+ Sbjct: 437 APDAFYALRLLESTGIVVVPGSGFGQVPGTWHFRCTILPQEDKIPAVISRFTVFHEAFMS 496 Query: 521 KY 522 +Y Sbjct: 497 EY 498 >1XI9-A nrPDB Length = 406 Score = 142 bits (357), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 119/461 (25%), Positives = 207/461 (44%), Gaps = 84/461 (18%) Query: 59 AVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTY 118 +VEYA+R +VL A E+E ++GIK VIR NIGD QP Sbjct: 18 SVEYAIRD-VVLPARELE---KKGIK-----VIRLNIGDPVKFDFQP------------- 55 Query: 119 PNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADP 178 PE K+ + ++ G N G S+G+ +R+ + +R GV P Sbjct: 56 ---------PEHMKEAYCKAIKE-GHNYYGD---SEGLPELRKAIVER-EKRKNGVDITP 101 Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE 238 D++ +T ++ + I L+ G + +++P P YP Y+ ++ V Y EE Sbjct: 102 DDVRVTAAVTEALQLIFGALLDPGDE----ILVPGPSYPPYTGLVKFYGGKPVEYRTIEE 157 Query: 239 NCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLA 298 W +++++R+ + + K + +INP NPTG + +K +E++++ A E ++ +++ Sbjct: 158 EDWQPDIDDIRKKITDRT-----KAIAVINPNNPTGALYDKKTLEEILNIAGEYEIPVIS 212 Query: 299 DEVYQDNVYSPDCRFHSFKKVLYEMGP-EYSSNVELASFHSTSKGYMGECGYRGGYMEVI 357 DE+Y Y + + P + +V + + SK Y G+R GYM + Sbjct: 213 DEIYDLMTYEGE-----------HISPGSLTKDVPVIVMNGLSKVYFA-TGWRLGYMYFV 260 Query: 358 ---NLHPEIKGQLVKLLSVRLCPPVSGQ-AAMDIVVNPPVAGEESFEQFSREKESVLGNL 413 N E++ + +L +RLCP Q AA+ + P +E ++ ++ + L Sbjct: 261 DPENKLSEVREAIDRLARIRLCPNTPAQFAAIAGLTGPMDYLKEYMKKLKERRDYIYKRL 320 Query: 414 AKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEE 473 N++PGI QGA Y FP+I + D + + +L Sbjct: 321 -----------NEIPGISTTKPQGAFYIFPKI----------EVGPWKNDKEFVLDVLHN 359 Query: 474 TGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 + V GSGFG+ G HFR LPP+E L+ + + + F Sbjct: 360 AHVLFVHGSGFGEY-GAGHFRAVFLPPIEILEEAMDRFEKF 399 >4CVQ-A nrPDB Length = 431 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 117/462 (25%), Positives = 203/462 (43%), Gaps = 75/462 (16%) Query: 56 QVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMAL 115 +++ V Y +RGP++ +A +E E + V++ NIG+ G Sbjct: 35 KLENVCYDIRGPVLKEAKRLEEEGNK--------VLKLNIGNPAPFG------------- 73 Query: 116 CTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVP 175 D+P E R + A G Y S+G+ R+ + + R G Sbjct: 74 ------FDAPD--EILVDVIRNLPTAQG------YCDSKGLYSARKAIMQHYQAR-GMRD 118 Query: 176 ADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 ++IY+ G S+ I ++ L++ G + +++P P YPL++A +S V+Y Sbjct: 119 VTVEDIYIGNGVSELIVQAMQALLNSGDE----MLVPAPDYPLWTAAVSLSSGKAVHYLC 174 Query: 236 DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 DE + W +++++R AK + + IINP NPTG V S++ + +++ A + L Sbjct: 175 DESSDWFPDLDDIR-----AKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLI 229 Query: 296 LLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 + ADE+Y D + D HS + + ++ +F+ SK Y G+R G+M Sbjct: 230 IFADEIY-DKILYDDAEHHSIAPL--------APDLLTITFNGLSKTYR-VAGFRQGWMV 279 Query: 356 VINLHPEIKGQ---LVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGN 412 + KG L L S+RLC V Q A + + G +S +F G Sbjct: 280 LNGPKKHAKGYIEGLEMLASMRLCANVPAQHA----IQTALGGYQSISEFITPG----GR 331 Query: 413 LAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLE 472 L ++ +L N +PG+ C +GA+Y FP+I A+ + D + L Sbjct: 332 LYEQRNRAWELINDIPGVSCVKPRGALYMFPKI--------DAKRFNIHDDQKMVLDFLL 383 Query: 473 ETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 + + +V G+ F HFR+ LP V+ ++ L K F Sbjct: 384 QEKVLLVQGTAFNW-PWPDHFRIVTLPRVDDIELSLSKFARF 424 >3PDX-A nrPDB Length = 402 Score = 91.7 bits (226), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 95/370 (25%), Positives = 167/370 (45%), Gaps = 46/370 (12%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ S G RE+VA+Y + P + ++ LT+G S I L +L + G + Sbjct: 69 YAPSIGYLSSREEVASYYHCPEA--PLEAKDVILTSGCSQAIELCLAVLANPG----QNI 122 Query: 210 MIPIPQYPLYSAVISELDAIQVNYY-LDEENCWALNVNELRRAVQEAKDHCDPKVLCIIN 268 +IP P + LY ++E I+V Y L E W +++ +L + E K C L + N Sbjct: 123 LIPRPGFSLYRT-LAESMGIEVKLYNLLPEKSWEIDLKQLESLIDE-KTAC----LVVNN 176 Query: 269 PGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYS 328 P NP G V S++ ++ ++ A + + +LADE+Y D V+S DC+ YE S Sbjct: 177 PSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFS-DCK--------YEPMATLS 227 Query: 329 SNVELASFHSTSKGYMGECGYRGGYMEVIN----LHPEIKGQLVKLLSVRLCPPVSGQAA 384 +NV + S +K ++ G+R G++ + + EI+ LVKL L P Q A Sbjct: 228 TNVPILSCGGLAKRWLVP-GWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGA 286 Query: 385 MDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPR 444 + ++ + + ++F ++ L L A L + +PG+ GAMY Sbjct: 287 LKSIL------QRTPQEFYQD---TLSFLKSNADLCYGALSAIPGLQPVRPSGAMYLM-- 335 Query: 445 IFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKL 504 +E + D+ + +L+ E + +P + F E FR+ I P + Sbjct: 336 -----VGIEMEHFPEFENDVEFTERLIAEQSVHCLPATCF---EYPNFFRVVITVPEVMM 387 Query: 505 KTVLQKVKDF 514 ++++F Sbjct: 388 LEACSRIQEF 397 >1GDE-A nrPDB Length = 389 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 96/393 (24%), Positives = 175/393 (44%), Gaps = 53/393 (13%) Query: 125 PSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDN-I 181 P F P+ K+ A+ L L Y + G+ +RE +A + ++ G+ ADP I Sbjct: 36 PDFDTPQHIKEYAKEALD----KGLTHYGPNIGLLELREAIAEKL-KKQNGIEADPKTEI 90 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYS--AVISELDAIQVNYYLDEEN 239 + GA+ L + G + V+IP P + Y+ +++ ++V Y EE+ Sbjct: 91 MVLLGANQAFLMGLSAFLKDGEE----VLIPTPAFVSYAPAVILAGGKPVEVPTY--EED 144 Query: 240 CWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 + LNV+EL++ V + + L I +P NPTG V ++K +E++ F E L +++D Sbjct: 145 EFRLNVDELKKYVTDK-----TRALIINSPCNPTGAVLTKKDLEEIADFVVEHDLIVISD 199 Query: 300 EVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 EVY+ +Y D R +S + + + + + F T G+R G++ + Sbjct: 200 EVYEHFIYD-DARHYS----IASLDGMFERTITVNGFSKT----FAMTGWRLGFVAAPSW 250 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 I ++VK PV+ + A E+ + E + ++ KL Sbjct: 251 ---IIERMVKFQMYNATCPVT-------FIQYAAAKALKDERSWKAVEEMRKEYDRRRKL 300 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 N++ G+ +GA Y FPRI + + F + +L+E + VV Sbjct: 301 VWKRLNEM-GLPTVKPKGAFYIFPRI----------RDTGLTSKKFSEL-MLKEARVAVV 348 Query: 480 PGSGFGQREGTYHFRMTILPPVEKLKTVLQKVK 512 PGS FG + G + R++ EKL+ + +++ Sbjct: 349 PGSAFG-KAGEGYVRISYATAYEKLEEAMDRME 380 >1J32-A nrPDB Length = 388 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 81/366 (22%), Positives = 153/366 (41%), Gaps = 46/366 (12%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y + G +RE +A + +RD G+ DNI +T G I ++ ++ G + V Sbjct: 63 YGPAAGEPRLREAIAQKL-QRDNGLCYGADNILVTNGGKQSIFNLMLAMIEPGDE----V 117 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 +IP P + Y ++ + V E + ++ ++R+A+ K+L P Sbjct: 118 IIPAPFWVSYPEMVKLAEGTPVILPTTVETQFKVSPEQIRQAITPKT-----KLLVFNTP 172 Query: 270 GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE-YS 328 NPTG V + + + A E L++L+DE+Y+ +Y D + S PE Y Sbjct: 173 SNPTGMVYTPDEVRAIAQVAVEAGLWVLSDEIYEKILYD-DAQHLSIGAA----SPEAYE 227 Query: 329 SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIV 388 +V + F T G+R G++ V L V+ + G + ++ Sbjct: 228 RSVVCSGFAKT----YAMTGWRVGFL----------AGPVPL--VKAATKIQGHSTSNVC 271 Query: 389 VNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIP 448 ++E + +L A++ + D N +PG+ C GA Y FP I Sbjct: 272 TFAQYGAIAAYENSQDCVQEMLAAFAERRRYMLDALNAMPGLECPKPDGAFYMFPSI--- 328 Query: 449 AKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVL 508 A + +C +LL++ + VPG+ FG + R++ ++ +K + Sbjct: 329 --------AKTGRSSLDFCSELLDQHQVATVPGAAFGADD---CIRLSYATDLDTIKRGM 377 Query: 509 QKVKDF 514 ++++ F Sbjct: 378 ERLEKF 383 >3DYD-A nrPDB Length = 427 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 92/373 (24%), Positives = 162/373 (43%), Gaps = 52/373 (13%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ S G RE++A+Y + P + ++ LT+G S I L +L + G + Sbjct: 92 YAPSIGFLSSREEIASYYHCPEA--PLEAKDVILTSGCSQAIDLCLAVLANPG----QNI 145 Query: 210 MIPIPQYPLYSAVISELDAIQVNYY-LDEENCWALNVNELRRAVQEAKDHCDPKVLCII- 267 ++P P + LY ++E I+V Y L E W +++ +L + E K C+I Sbjct: 146 LVPRPGFSLYKT-LAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDE-------KTACLIV 197 Query: 268 -NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 NP NP G V S++ ++ ++ A + + +LADE+Y D V+S DC++ + Sbjct: 198 NNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFS-DCKYEPLATL------- 249 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVIN----LHPEIKGQLVKLLSVRLCPPVSGQ 382 S++V + S +K ++ G+R G++ + + EI+ LVKL L P Q Sbjct: 250 -STDVPILSCGGLAKRWLVP-GWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQ 307 Query: 383 AAM-DIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 A+ I+ P GE + L L A L +PG+ GAMY Sbjct: 308 GALKSILCRTP--GE--------FYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYL 357 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPV 501 +E + D+ + +L+ E + +P + F E R+ I P Sbjct: 358 M-------VGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCF---EYPNFIRVVITVPE 407 Query: 502 EKLKTVLQKVKDF 514 + ++++F Sbjct: 408 VMMLEACSRIQEF 420 >1BW0-A nrPDB Length = 416 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 87/343 (25%), Positives = 153/343 (44%), Gaps = 45/343 (13%) Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE 238 DN+ L +G S GI + + G + ++P P +P Y V Y E Sbjct: 105 DNVVLCSGGSHGILMAITAICDAGDYA----LVPQPGFPHYETVCKAYGIGMHFYNCRPE 160 Query: 239 NCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLA 298 N W +++E+RR + K+L + NP NP G SRK +ED++ A E +L L + Sbjct: 161 NDWEADLDEIRRLKDDKT-----KLLIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFS 215 Query: 299 DEVYQDNVY---SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 DE+Y V+ P+ F S ++ + V T+K + G+R G++ Sbjct: 216 DEIYAGMVFKGKDPNATFTSVA--------DFETTVPRVILGGTAKNLVVP-GWRLGWLL 266 Query: 356 VINLHPEIKGQL--VKLLSVRLCPPVS-GQAAM-DIVVNPPVAGEESFEQFSREKESVLG 411 ++ H L +K + + +C P + QAA+ + ++N P +E +Q ++ Sbjct: 267 YVDPHGNGPSFLEGLKRVGMLVCGPCTVVQAALGEALLNTP---QEHLDQ-------IVA 316 Query: 412 NLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLL 471 + + A + + G+ +GAMY RI + + + D+ + KLL Sbjct: 317 KIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRI-------DLEKYRDIKTDVEFFEKLL 369 Query: 472 EETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 EE + V+PG+ F T R+T PVE + ++++K F Sbjct: 370 EEENVQVLPGTIFHAPGFT---RLTTTRPVEVYREAVERIKAF 409 >2Z61-A nrPDB Length = 370 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 97/370 (26%), Positives = 156/370 (42%), Gaps = 69/370 (18%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPAD--PDNIYLTTGASDGISTILKILVSGGGKSRT 207 Y+ S+G+ +RE ++ + AD PDNI +T G+S G+ L ++ G + Sbjct: 62 YTDSRGILELREKISELYKDK---YKADIIPDNIIITGGSSLGLFFALSSIIDDGDE--- 115 Query: 208 GVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 V+I P YP Y I L A V + D V L A+ + K + I Sbjct: 116 -VLIQNPCYPCYKNFIRFLGAKPV--FCD------FTVESLEEALSDK-----TKAIIIN 161 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 +P NP G+V R+ E FA+E ++++DE+Y VY C E+ Sbjct: 162 SPSNPLGEVIDREIYE----FAYENIPYIISDEIYNGLVYEGKCY----------SAIEF 207 Query: 328 SSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL--CPPVSGQAAM 385 N+E + G+R GY VI+ + EI ++KL P +S AA+ Sbjct: 208 DENLEKTILINGFSKLYAMTGWRIGY--VIS-NDEIIEAILKLQQNLFISAPTISQYAAL 264 Query: 386 DIVVNPPVAGEESFE-QFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPR 444 ++FE + RE S++ ++ +L NP+ GA Y FP Sbjct: 265 -----------KAFEKETEREINSMIKEFDRRRRLVLKYVKDFGWEVNNPI-GAYYVFPN 312 Query: 445 IFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKL 504 I + A KLL+E + + PG GFG + G + R++ E + Sbjct: 313 I--------GEDGREFA------YKLLKEKFVALTPGIGFGSK-GKNYIRISYANSYENI 357 Query: 505 KTVLQKVKDF 514 K L+++K+F Sbjct: 358 KEGLERIKEF 367 >5YHV-A nrPDB Length = 394 Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 87/378 (23%), Positives = 149/378 (39%), Gaps = 61/378 (16%) Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGK 204 N LG YS + G+ +R+ +AA RR G + +PD + +TTG+S G +L L Sbjct: 66 NQLG-YSVALGIPELRDAIAADYQRRHG-ITVEPDAVVITTGSSGGF--LLAFLACFDAG 121 Query: 205 SRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKV- 263 R V + P YP Y ++S L V + + L DP + Sbjct: 122 DR--VAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLA--------EIDPPLR 171 Query: 264 -LCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYS----PDCRFHSFKK 318 + + +P NPTG V + + + + + L++DEVY VY C + + + Sbjct: 172 GVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQTSRN 231 Query: 319 VLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLS--VRLC 376 + +S SK Y G+R G++ L P + + V L+ +C Sbjct: 232 AVV--------------VNSFSK-YYAMTGWRLGWL----LVPTVLRRAVDCLTGNFTIC 272 Query: 377 PPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQ 436 PPV Q A P + + E + L + A L D ++ P Sbjct: 273 PPVLSQIAAVSAFTP---------EATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTD 323 Query: 437 GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMT 496 GA Y + + + + + +C KLL +TG+ + PG F G R++ Sbjct: 324 GAFYVYADV-----------SDFTSDSLAFCSKLLADTGVAIAPGIDFDTARGGSFVRIS 372 Query: 497 ILPPVEKLKTVLQKVKDF 514 P ++ L+++ + Sbjct: 373 FAGPSGDIEEALRRIGSW 390 >4IX8-A nrPDB Length = 444 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 88/380 (23%), Positives = 153/380 (40%), Gaps = 43/380 (11%) Query: 147 LGSYSASQGVNCIREDVAAYITR----RDGGVPADPDNIYLTTGASDGISTILKILVSGG 202 Y + G + +R+ V+ Y R + +N+ +T+G S I L L + G Sbjct: 102 FNGYPPTVGADNLRQVVSTYWRRFCQTKSRQEALKWENVIITSGVSQAIVLALTALCNEG 161 Query: 203 GKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK 262 +++ P +P Y +V YYLD W +LR A H K Sbjct: 162 DN----ILVCAPSFPHYKSVCDSYGIECRYYYLDPSKSWEC---DLRAAAGMVDSH--TK 212 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYE 322 IINP NP G SR + D+I F + ++ L++DE+Y + V ++ Sbjct: 213 AFVIINPSNPCGSNFSRAHVSDIIDFCQQHQIPLISDEIYAEMV---------LNNGIFT 263 Query: 323 MGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ 382 ++ +NV T+K Y G+R G+ +I+ + G + RL ++G Sbjct: 264 SVADFDTNVPRLILGGTAK-YQVCPGWRVGWSILIDPM-NVAGDWAVGME-RLTQLIAG- 319 Query: 383 AAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAF 442 ++ + +A + + E ++ L AK+ L GI Q +M+ Sbjct: 320 --VNSICQEAIA-RTLLKCPTECTEHIVTQLEAGAKVYARLLEHDIGISMEAPQASMFVM 376 Query: 443 PRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVE 502 ++ + + + DM + KLL+E + V+PG FG + R T+ P Sbjct: 377 LKLNL-------SYFQDLKSDMEFYEKLLDEENVQVLPGEIFGM---SGFLRATVSRP-- 424 Query: 503 KLKTVLQKVKDFHINFLEKY 522 VL + D I F E++ Sbjct: 425 --SAVLNEAVDRIIEFCERH 442 >1GC4-A nrPDB Length = 385 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 87/391 (22%), Positives = 153/391 (39%), Gaps = 59/391 (15%) Query: 125 PSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 P F PE K+ ARR L Y+ G+ +RE +A RR+ G+ P+ Sbjct: 41 PDFDTPEHVKEAARRAL----AQGKTKYAPPAGIPELREALAEKF-RRENGLSVTPEETI 95 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 +T G S + + + ++ G + V++ P + Y ++ + V E + Sbjct: 96 VTVGGSQALFNLFQAILDPGDE----VIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFV 151 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 + +RRA+ K L + +P NPTG V ++ +E + A E +L++DE+Y Sbjct: 152 PDPERVRRAITPRT-----KALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIY 206 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 + +Y + F + + PE++ V A+ G+ GY G EVI Sbjct: 207 EHLLYEGE-HFSPGR-----VAPEHTLTVNGAAKAFAMTGW--RIGYACGPKEVIKAMAS 258 Query: 363 IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG---EESFEQFSREKESVLGNLAKKAKL 419 + Q S ++ A ++ + N + E + E + R ++ +L L Sbjct: 259 VSRQ-----STTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTAL--- 310 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 G+ GA Y +APD + L E G+ VV Sbjct: 311 ---------GLKAVRPSGAFYVL------------MDTSPIAPDEVRAAERLLEAGVAVV 349 Query: 480 PGSGFGQREGTYHFRMTILPPVEKLKTVLQK 510 PG+ F H R++ E L+ L++ Sbjct: 350 PGTDFA---AFGHVRLSYATSEENLRKALER 377 >6F35-A nrPDB Length = 410 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 84/354 (23%), Positives = 146/354 (41%), Gaps = 54/354 (15%) Query: 169 RRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDA 228 +R+ G+ + D I + TGA + + + G + V+IP P + YS ++ + Sbjct: 92 QRENGLAYELDEITVATGAKQILFNAMMASLDPGDE----VIIPTPYWTSYSDIVHICEG 147 Query: 229 IQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII--NPGNPTGQVQS----RKCI 282 V D + + L +L A+ P+ ++ +P NP+G S R + Sbjct: 148 KPVLIACDASSGFRLTAEKLEAAIT-------PRTRWVLLNSPSNPSGAAYSAADYRPLL 200 Query: 283 EDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKG 342 E ++ ++LL D++Y+ VY F E G + + + + SK Sbjct: 201 EVLLR---HPHVWLLVDDMYEHIVYD---GFRFVTPAQLEPGLKNRT----LTVNGVSKA 250 Query: 343 YM---GECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG-EES 398 Y GY GG E+I ++ Q CP QAA + +N P +E Sbjct: 251 YAMTGWRIGYAGGPRELIKAMAVVQSQATS------CPSSISQAASVVALNGPQDFLKER 304 Query: 399 FEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIF-IPAKAVEAAQA 457 E F R ++ V+ L N + G+ C +GA Y F + K + + Sbjct: 305 TESFQRRRDLVVNGL-----------NAIDGLDCRVPEGAFYTFSGCAGVLGKVTPSGK- 352 Query: 458 HQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKV 511 ++ D +C LLE+ + VVPGS FG + FR++ +LK L+++ Sbjct: 353 -RIKTDTDFCAYLLEDAHVAVVPGSAFGL---SPFFRISYATSEAELKEALERI 402 >4MY5-A nrPDB Length = 393 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 95/431 (22%), Positives = 192/431 (44%), Gaps = 69/431 (16%) Query: 106 ITFLRQV-MALCTYPNLLD----SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNC 158 ++ +RQ ++ P++L P F P+ K+ A+R + A + Y+ G+ Sbjct: 18 VSMIRQFDQSISDIPDVLKLTLGEPDFATPKHIKEAAKRAIDADESH----YTGMAGLLA 73 Query: 159 IREDVAAYITRRDGGVPADPDN-IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP 217 +R+ +A++ + + +PDN I +T GA++ +S L ++ G K V++P P YP Sbjct: 74 LRQAASAFVKEK-YHLTYNPDNEILVTIGATEALSASLTAILEPGDK----VLLPAPAYP 128 Query: 218 LYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQ 277 Y V++ + A +V N + L L A+ + + K + + P NPTG Sbjct: 129 GYEPVVNLVGA-EVVEIDTRSNDFVLTPEMLEEAILKEGEAL--KAVILNYPTNPTGVTY 185 Query: 278 SRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVE-LASF 336 SR+ I+++ + +F+++DEVY + Y+ + + E P+ + + L+ Sbjct: 186 SRQQIKNLAEVLKKYPIFVISDEVYAELTYTGESHVS-----IAEYLPDQTILISGLSKS 240 Query: 337 HSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ--AAMDIVVNPPVA 394 H+ + G+R G +I + QL+K + + AA++ + N Sbjct: 241 HAMT-------GWRLG---LIFAPAVLTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDD 290 Query: 395 GEESFEQFSREKESVLGNL-AKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVE 453 E++ + ++ ++ + A K K+ + GA Y F +I + Sbjct: 291 ALPMKEEYIKRRDYIIEKMEAMKFKIIKP-------------DGAFYIFAKIPV------ 331 Query: 454 AAQAHQMAPDMF-YCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVK 512 AQ D F + +E + +PG FG + G + R++ +E +K ++++K Sbjct: 332 -AQGQ----DSFKFLQDFAKEKAVAFIPGVAFG-KYGEGYLRISYAASMETIKEAMKRLK 385 Query: 513 DFHINFLEKYA 523 + F+E+YA Sbjct: 386 E----FMEQYA 392 >1IAY-A nrPDB Length = 428 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 69/300 (23%), Positives = 131/300 (43%), Gaps = 20/300 (6%) Query: 146 SLGSYSASQGVNCIREDVAAYITRRDGG-VPADPDNIYLTTGASDGISTILKILVSGGGK 204 ++ ++ G+ R+ +A ++ + GG V DP+ + + GA+ TI+ L G Sbjct: 75 AIANFQDYHGLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPG-- 132 Query: 205 SRTGVMIPIPQYPLYSAVISELDAIQ-VNYYLDEENCWALNVNELRRAVQEA-KDHCDPK 262 ++P P YP ++ + +Q + + + N + + ++ A + A K + K Sbjct: 133 --DAFLVPSPYYPAFNRDLRWRTGVQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKVK 190 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYE 322 L + NP NP G + ++ V+ F + + L+ DE+Y V+ +F S ++L E Sbjct: 191 GLILTNPSNPLGTTLDKDTLKSVLSFTNQHNIHLVCDEIYAATVFDTP-QFVSIAEILDE 249 Query: 323 MGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ 382 Y + + +S SK MG G+R G + + + ++ K+ S L VS Q Sbjct: 250 QEMTYCNKDLVHIVYSLSKD-MGLPGFRVGI--IYSFNDDVVNCARKMSSFGL---VSTQ 303 Query: 383 AAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAF 442 + ++ E+ + F RE LG K T L +V GI C ++ + Sbjct: 304 TQY--FLAAMLSDEKFVDNFLRESAMRLGKRHK--HFTNGL--EVVGIKCLKNNAGLFCW 357 >2GB3-A nrPDB Length = 409 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 74/276 (26%), Positives = 120/276 (43%), Gaps = 48/276 (17%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 YS S G+ +RE A+Y RR V P+N+ +T G S+ I ++ + G + + Sbjct: 75 YSHSAGIWELREAFASYYKRRQR-VDVKPENVLVTNGGSEAILFSFAVIANPGDE----I 129 Query: 210 MIPIPQYPLYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 ++ P Y Y+A I+ + I V ++E N+ E+ + K + + Sbjct: 130 LVLEPFYANYNAFAKIAGVKLIPVTRRMEEGFAIPQNL--------ESFINERTKGIVLS 181 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 NP NPTG V + + ++ A LFL+ DEVY + V+ E+ Sbjct: 182 NPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYSEIVFR----------------GEF 225 Query: 328 SSNVELAS-----FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ 382 +S + + S S SK + CG R G + I + E+ +KL RL PP+ Q Sbjct: 226 ASALSIESDKVVVIDSVSKKFSA-CGARVGCL--ITRNEELISHAMKLAQGRLAPPLLEQ 282 Query: 383 AAMDIVVNPPVAGEESFEQFSREK-----ESVLGNL 413 ++N ++SF F RE E+VL L Sbjct: 283 IGSVGLLNL----DDSFFDFVRETYRERVETVLKKL 314 >5WMH-A nrPDB Length = 475 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 79/371 (21%), Positives = 154/371 (41%), Gaps = 40/371 (10%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ + G+ +RE + + + + G+ PD I ++ GA + + + S G + V Sbjct: 132 YTLNAGITELREAICRKL-KEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDE----V 186 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 +IP P + Y+ DA V N + L+ +L + E ++L + +P Sbjct: 187 IIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKS-----RLLILCSP 241 Query: 270 GNPTGQVQSRKCIEDVIH-FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYS 328 NPTG V + +E++ A +L +L+DE+Y+ +Y+P H+ L +M Y Sbjct: 242 SNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPAT--HTSFASLPDM---YE 296 Query: 329 SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIV 388 + + F GY G ++ +++GQ+ S ++ +A + + Sbjct: 297 RTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGAS-----SIAQKAGVAAL 351 Query: 389 VNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIP 448 GE E +E ++ L + L + G+ + QGA Y +FI Sbjct: 352 GLGKAGGETVAEMVKAYRE-------RRDFLVKSL-GDIKGVKISEPQGAFY----LFID 399 Query: 449 AKAVEAAQAHQMA---PDMFYCMKLLEETGICVVPGSGFGQREG---TYHFRMTIL-PPV 501 A ++A + L++ + +VPG FG +Y + +L V Sbjct: 400 FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAV 459 Query: 502 EKLKTVLQKVK 512 EK++ L+ ++ Sbjct: 460 EKIRKALEPLR 470 >1O4S-A nrPDB Length = 389 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 90/403 (22%), Positives = 153/403 (37%), Gaps = 80/403 (19%) Query: 123 DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 D P+ PE + A R LQ Y+ +G+ +RE +A I R PD + Sbjct: 52 DFPT-PEPVVEEAVRFLQ----KGEVKYTDPRGIYELREGIAKRIGERYKK-DISPDQVV 105 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIP-----IPQYPLYSAVISELDA-IQVNYYLD 236 +T GA + L+ G + V P IPQ L ++ ++ + N+ Sbjct: 106 VTNGAKQALFNAFMALLDPGDE--VIVFSPVWVSYIPQIILAGGTVNVVETFMSKNFQPS 163 Query: 237 EENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFL 296 E L V + K + I +P NPTG V R+ +E ++ A + ++ Sbjct: 164 LEEVEGLLVGK-------------TKAVLINSPNNPTGVVYRREFLEGLVRLAKKRNFYI 210 Query: 297 LADEVYQDNVYSPDCRF-----HSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRG 351 ++DEVY VY+ + F +++Y G + HS + G+R Sbjct: 211 ISDEVYDSLVYTDEFTSILDVSEGFDRIVYING--------FSKSHSMT-------GWRV 255 Query: 352 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLG 411 GY+ + E V + ++ A + V + F K V+ Sbjct: 256 GYL----ISSEKVATAVSKIQSHTTSCINTVAQYAALKALEVDNSYMVQTFKERKNFVVE 311 Query: 412 NLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLL 471 L K G+ +GA Y F ++ D+ +C +LL Sbjct: 312 RLKKM------------GVKFVEPEGAFYLFFKV--------------RGDDVKFCERLL 345 Query: 472 EETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 EE + +VPGS F + G R++ +E+L L +++DF Sbjct: 346 EEKKVALVPGSAF-LKPG--FVRLSFATSIERLTEALDRIEDF 385 >2X5D-A nrPDB Length = 412 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 84/371 (22%), Positives = 166/371 (44%), Gaps = 57/371 (15%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDN-IYLTTGASDGISTILKILVSGGGKSRTG 208 YS S+G+ +R ++ + R V DP++ +T G+ +G++ ++ + G Sbjct: 71 YSTSRGIPRLRRAISHWYRDR-YDVQIDPESEAIVTIGSKEGLAHLMLATLDHGDT---- 125 Query: 209 VMIPIPQYPL--YSAVIS--ELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVL 264 +++P P YP+ Y AVI+ ++ ++ + +D NEL RA++E+ P+++ Sbjct: 126 ILVPNPSYPIHIYGAVIAGAQVRSVPLVPGID-------FFNELERAIRESIPK--PRMM 176 Query: 265 CIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMG 324 + P NPT Q E V+ A + + ++ D Y D VY + S +V Sbjct: 177 ILGFPSNPTAQCVELDFFERVVALAKQYDVMVVHDLAYADIVYD-GWKAPSIMQV----- 230 Query: 325 PEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVR---LCPPVSG 381 + ++ + F + SK Y G+R G+M V N PE+ L ++ S P+ Sbjct: 231 -PGAKDIAV-EFFTLSKSY-NMAGWRIGFM-VGN--PELVSALARIKSYHDYGTFTPLQ- 283 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 AA+ + + Q+ + ++ ++ L + + E NP + +MY Sbjct: 284 VAAIAALEGDQQCVRDIARQYQQRRDVLVKGLREAGWMVE-----------NP-KASMYV 331 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPV 501 + +I P + + + + KLL++ + V PG GFG G H R ++ Sbjct: 332 WAKIPEPYAHLGSLE---------FAKKLLQDAKVSVSPGIGFGD-YGDDHVRFALIENR 381 Query: 502 EKLKTVLQKVK 512 ++L+ ++ +K Sbjct: 382 DRLRQAVRGIK 392 >6F77-B nrPDB Length = 400 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 83/346 (23%), Positives = 133/346 (38%), Gaps = 50/346 (14%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ G+ +RE +A R + I T G + + L G V Sbjct: 64 YTPVSGIPELREAIAKKFKRENNLDYTAAQTIVGTGGKQILFNAFMATLNPG-----DEV 118 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 +IP P + Y +++ V +EN + L +L RA+ K +P Sbjct: 119 VIPAPYWVSYPEMVALCGGTPVFVPTRQENNFKLKAEDLDRAITPKT-----KWFVFNSP 173 Query: 270 GNPTGQVQSR---KCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKV---LYEM 323 NP+G S K + DV+ +++L D++Y+ Y D RF + +V LYE Sbjct: 174 SNPSGAAYSHEELKALTDVLMK--HPHVWVLTDDMYEHLTYG-DFRFATPVEVEPGLYE- 229 Query: 324 GPEYSSNVELASFHSTSKGYM---GECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVS 380 + + SK Y GY G + +I I+GQ ++ Sbjct: 230 --------RTLTMNGVSKAYAMTGWRIGYAAGPLHLIKAMDMIQGQ-----QTSGAASIA 276 Query: 381 GQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMY 440 AA++ + P + F R KE G + L + NQ GI C +GA Y Sbjct: 277 QWAAVEALNGP-----QDF--IGRNKEIFQG----RRDLVVSMLNQAKGISCPTPEGAFY 325 Query: 441 AFPRIF-IPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFG 485 +P + K + + + D + +LLE G+ VV GS FG Sbjct: 326 VYPSCAGLIGKTAPSGKVIETDED--FVSELLETEGVAVVHGSAFG 369 >3OP7-A nrPDB Length = 375 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 101/402 (25%), Positives = 167/402 (41%), Gaps = 87/402 (21%) Query: 124 SPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYL 183 S + PED K+ LQ N Y +G ++ V+ T GV P+ I Sbjct: 41 SGTNPEDFYKK----LQGTKLN----YGWIEGSPAFKKSVSQLYT----GVK--PEQILQ 86 Query: 184 TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVI-------SELDAIQVNYYLD 236 T GA+ +L L+ G I YP Y + +E+D Q+ + Sbjct: 87 TNGATGANLLVLYSLIEPGDHV-------ISLYPTYQQLYDIPKSLGAEVDLWQI----E 135 Query: 237 EENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFL 296 EEN W ++ +LR+ ++ K++CI N NPTG V R +E+++ A E ++ Sbjct: 136 EENGWLPDLEKLRQLIRPTT-----KMICINNANNPTGAVMDRTYLEELVEIASEVGAYI 190 Query: 297 LADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEV 356 L+DEVY+ + S +V Y+ G + +S SK Y G R G++ Sbjct: 191 LSDEVYRS---FSELDVPSIIEV-YDKG---------IAVNSLSKTY-SLPGIRIGWVAA 236 Query: 357 INLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKK 416 + +I L R + D+V +A + E R + + NLA Sbjct: 237 NHQVTDI------LRDYRDYTMICAGVFDDLVAQLALAHYQ--EILERNRHILEENLAIL 288 Query: 417 AKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDM---FYCMKLLEE 473 + E+ PL Y P AV + ++A DM +C++LL+E Sbjct: 289 DQWIEE----------EPL--VSYIRP-------AVVSTSFVKIAVDMPMEDFCLQLLQE 329 Query: 474 TGICVVPGSGFGQREGTYHF-----RMTILPPVEKLKTVLQK 510 G+ +VPG+ F +R+G + T++ +EKL L++ Sbjct: 330 HGVLLVPGNRF-ERDGYVRLGFACEQETLIKGLEKLSQFLRR 370 >1M4N-A nrPDB Length = 435 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 86/187 (45%), Gaps = 10/187 (5%) Query: 170 RDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAI 229 R V DP+++ LT GA+ T + L G V+IP P YP + + + Sbjct: 103 RGNKVTFDPNHLVLTAGATSANETFIFCLADPG----EAVLIPTPYYPGFDRDLKWRTGV 158 Query: 230 Q-VNYYLDEENCWALNVNELRRAVQEA-KDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 + V + N + + L A QEA K + K + + NP NP G +R + ++ Sbjct: 159 EIVPIHCTSSNGFQITETALEEAYQEAEKRNLRVKGVLVTNPSNPLGTTMTRNELYLLLS 218 Query: 288 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNV--ELASFHSTSKGYMG 345 F ++ + L++DE+Y +S F S +VL + + +S V + +S SK +G Sbjct: 219 FVEDKGIHLISDEIYSGTAFSSPS-FISVMEVLKDRNCDENSEVWQRVHVVYSLSKD-LG 276 Query: 346 ECGYRGG 352 G+R G Sbjct: 277 LPGFRVG 283 >1V2E-A nrPDB Length = 381 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 25/196 (12%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ G+ +RE +A +P+++ +T+GA++ + +L+ LV G + V Sbjct: 57 YAPPAGLPALREALAEEFA-------VEPESVVVTSGATEALYVLLQSLVGPGDE----V 105 Query: 210 MIPIPQYPLY--SAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 ++ P + +Y A ++ A V L E + L+++ L +A+ + L + Sbjct: 106 VVLEPFFDVYLPDAFLAGAKARLVRLDLTPEG-FRLDLSALEKALTPRT-----RALLLN 159 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 P NPTG V + +E + A LFL++DEVY + Y R L E PE Sbjct: 160 TPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPR------RLREFAPER 213 Query: 328 SSNVELASFHSTSKGY 343 + V A + GY Sbjct: 214 TFTVGSAGKRLEATGY 229 >3ASB-A nrPDB Length = 400 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 80/330 (24%), Positives = 125/330 (37%), Gaps = 48/330 (14%) Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 SDG L L+S G ++T V I P YP Y LD ++ + AL + Sbjct: 101 SDGAKVDLFRLLSFFGPNQT-VAIQDPSYPAY------LDIARLT---GAKEIIALPCLQ 150 Query: 248 LRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 E + +LC+ +P NPTG V ++ + ++H+A E ++ +L D Y + Sbjct: 151 ENAFFPEFPEDTHIDILCLCSPNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFIS 210 Query: 308 SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL 367 P S K ++E+ +E+ SF +G G R G+ + G Sbjct: 211 DP-----SLPKSIFEIPDARFCAIEINSFSKP----LGFAGIRLGWTVIPQELTYADGHF 261 Query: 368 VKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQ-----FSREKESVLGNLAKKAKLTED 422 V R A++ VAG Q + RE +L +KA L Sbjct: 262 VIQDWERFLSTTFNGASIP-AQEAGVAGLSILPQLEAIHYYRENSDLL----RKALLATG 316 Query: 423 LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGS 482 F G H P V+ QA+ D+F L E I + PG Sbjct: 317 -FEVFGGEHA---------------PYLWVKPTQANISDRDLFDF--FLREYHIAITPGI 358 Query: 483 GFGQREGTYHFRMTILPPVEKLKTVLQKVK 512 GFG R G+ R + L E + ++++ Sbjct: 359 GFG-RSGSGFVRFSSLGKREDILAACERLQ 387 >3H14-A nrPDB Length = 391 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 80/379 (21%), Positives = 148/379 (39%), Gaps = 69/379 (18%) Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDG---GVPADPDNIYLTTGASDGISTILKILVSG 201 ++LG Y+ + G+ +R+ +A R G GV DP + +T G+S G L Sbjct: 60 DALG-YTVALGLPALRQRIA----RLYGEWYGVDLDPGRVVITPGSSGGFLLAFTALFDS 114 Query: 202 GGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDP 261 G + V I P YP Y ++ L + V+ EN + V D Sbjct: 115 GDR----VGIGAPGYPSYRQILRALGLVPVDLPTAPENRL--------QPVPADFAGLDL 162 Query: 262 KVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY 321 L + +P NPTG + + +I A + ++DE+Y Y Sbjct: 163 AGLMVASPANPTGTMLDHAAMGALIEAAQAQGASFISDEIYHGIEYEAKA---------- 212 Query: 322 EMGPEYSSNVELAS----FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLS--VRL 375 + +EL +S SK Y G+R G+M V PE + ++V+ ++ + + Sbjct: 213 ------VTALELTDECYVINSFSK-YFSMTGWRVGWMVV----PEDQVRVVERIAQNMFI 261 Query: 376 CPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPL 435 C P + Q A ++ + + + + ++ +L L K F ++ P Sbjct: 262 CAPHASQVAALAALDCDAELQANLDVYKANRKLMLERLPKAG------FTRI-----APP 310 Query: 436 QGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRM 495 GA Y + + + + ++A + ++LE+ G+ V PG F G R Sbjct: 311 DGAFYVYADV---SDLTDDSRA--------FAAEILEKAGVAVTPGLDFDPERGAGTLRF 359 Query: 496 TILPPVEKLKTVLQKVKDF 514 + ++ L +++ F Sbjct: 360 SYARATADIEEGLDRLEAF 378 >3QGU-A nrPDB Length = 449 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 85/370 (22%), Positives = 140/370 (37%), Gaps = 46/370 (12%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y A QG +RE VA+ G D I+++ G+ I+ I + S+ V Sbjct: 107 YGAEQGQGALREAVASTFYGHAGRAA---DEIFISDGSKCDIARIQMMF-----GSKPTV 158 Query: 210 MIPIPQYPLY--SAVISELDAIQVNYYLDEENCWALN-VNELRRAVQEAKDHCDPKVLCI 266 + P YP+Y ++V+ + D N N + +AK D C Sbjct: 159 AVQDPSYPVYVDTSVMMGMTGDHNGTGFDGIEYMVCNPDNHFFPDLSKAK-RTDIIFFC- 216 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 +P NPTG +R + ++++FA + L+ D Y + +PDC K +YE+ Sbjct: 217 -SPNNPTGAAATRAQLTELVNFARKNGSILVYDAAYALYISNPDC-----PKTIYEIPGA 270 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMD 386 +E SF Y G G R G+ V G+ V R+ A + Sbjct: 271 DEVAIETCSFSK----YAGFTGVRLGWTVVPKALKYANGEPVHADWNRVMTTCF-NGASN 325 Query: 387 IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIF 446 IV +A + + +E +++ + A++ + F ++ G A Y + + Sbjct: 326 IVQAGGLACLQP--EGLKEMNAMIKFYKENAQILKTTFTEM-GFSVYGGDDAPYIW--VG 380 Query: 447 IPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQ------REGTYHFRMTILPP 500 P K P ++LE I PGSG+G R + R IL Sbjct: 381 FPGK-----------PSWDVFAEILERCNIVTTPGSGYGPAGEGFVRASAFGSRENILEA 429 Query: 501 VEKLKTVLQK 510 V + K K Sbjct: 430 VRRFKEAYGK 439 >3B1C-A nrPDB Length = 392 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 22/156 (14%) Query: 177 DPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD 236 D ++I G IS I + K V+I P YP ++ + + V+ L Sbjct: 88 DKEDIVFVEGVVPAIS----IAIQAFTKEGEAVLINSPVYPPFARSVRLNNRKLVSNSLK 143 Query: 237 EEN-CWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 EEN + ++ +L + E D K+ + NP NP G+V R+ +E + H + + Sbjct: 144 EENGLFQIDFEQLENDIVEN----DVKLYLLCNPHNPGGRVWEREVLEQIGHLCQKHHVI 199 Query: 296 LLADEVYQD-----------NVYSPDCRFHSFKKVL 320 L++DE++QD N SPD F F VL Sbjct: 200 LVSDEIHQDLTLFGHEHVSFNTVSPD--FKDFALVL 233 >2O0R-A nrPDB Length = 411 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/137 (31%), Positives = 68/137 (49%), Gaps = 11/137 (8%) Query: 173 GVPADPDN-IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQV 231 GV DP+ + +T GA++ I+ + LV G + V++ P Y YS V++ A +V Sbjct: 80 GVDYDPETEVLVTVGATEAIAAAVLGLVEPGSE----VLLIEPFYDSYSPVVAMAGAHRV 135 Query: 232 NYYL-DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAW 290 L + +AL+ + LRRAV + L I +P NPTG V S + + A Sbjct: 136 TVPLVPDGRGFALDADALRRAVTPRT-----RALIINSPHNPTGAVLSATELAAIAEIAV 190 Query: 291 EEKLFLLADEVYQDNVY 307 L ++ DEVY+ V+ Sbjct: 191 AANLVVITDEVYEHLVF 207 >3ELE-A nrPDB Length = 398 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 80/169 (47%), Gaps = 16/169 (9%) Query: 146 SLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKS 205 +L Y+++QG R +A ++ G + DN+Y+T GA+ +S + L S Sbjct: 68 ALHGYTSAQGDVETRAAIAEFLNNTHG-THFNADNLYMTMGAAASLSICFRALTSDAYDE 126 Query: 206 RTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLC 265 + P +P Y ++ A V D E+ + ++ + L E + + + + Sbjct: 127 FITIA---PYFPEYKVFVNAAGARLVEVPADTEH-FQIDFDAL-----EERINAHTRGVI 177 Query: 266 IINPGNPTGQVQSRKCIE---DVIHFAWEE---KLFLLADEVYQDNVYS 308 I +P NP+G V S + I+ D++ +E +F++ADE Y++ VY Sbjct: 178 INSPNNPSGTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEPYREIVYD 226 >2ZY2-A nrPDB Length = 544 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 29/207 (14%) Query: 163 VAAYITRR--DGGVPADPDNIYLTTGASDGISTILKIL-VSGGGKSRTGVMIPIPQYPLY 219 V YI R G VP + +++ G + ++ I + L +SG K+ V I +P + Y Sbjct: 147 VRQYIVREMAGGAVPPESVDLFAVEGGTAAMAYIFESLRISGLLKAGDKVAIGMPVFTPY 206 Query: 220 SAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQ 277 + +++ D +V + D +N W + EL + KD D K+ +NP NP Sbjct: 207 IEIPELAQYDLKEVPIHADPDNGWQYSDAEL----DKLKD-PDVKIFFCVNPSNPPSVKM 261 Query: 278 SRKCIEDVIHFAWEEK--LFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 ++ ++ V E++ L +L D+VY F + L+ + P + V Sbjct: 262 DQRSLDRVRAIVAEQRPDLLILTDDVY--------GTFADEFQSLFSVCPRNTLLV---- 309 Query: 336 FHSTSKGYMGECGYRGGYMEVINLHPE 362 +S SK Y G G+R G VI H + Sbjct: 310 -YSFSK-YFGATGWRLG---VIAAHKD 331 >3B46-A nrPDB Length = 447 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 72/327 (22%), Positives = 141/327 (43%), Gaps = 49/327 (14%) Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYY---- 234 +N+ +TTGA++GI + L L++ G + V++ P + Y I EL +V Y Sbjct: 119 ENVTVTTGANEGILSCLMGLLNAGDE----VIVFEPFFDQYIPNI-ELCGGKVVYVPINP 173 Query: 235 ---LDEENC----WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 LD+ N W ++ + +A+ K + I P NP G+V +R+ + + + Sbjct: 174 PKELDQRNTRGEEWTIDFEQFEKAITSKT-----KAVIINTPHNPIGKVFTREELTTLGN 228 Query: 288 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 347 + + +++DEVY+ ++Y D SF ++ + PE +L ++ Sbjct: 229 ICVKHNVVIISDEVYE-HLYFTD----SFTRIA-TLSPEIG---QLTLTVGSAGKSFAAT 279 Query: 348 GYRGGYMEVINLHPEIKGQLVKLLSVRLC---PPVSGQAAMDIVVNPPVAGEESFEQFSR 404 G+R G+ V++L+ E+ K R+C P +A + + + G FE+ + Sbjct: 280 GWRIGW--VLSLNAELLSYAAK-AHTRICFASPSPLQEACANSINDALKIG--YFEKMRQ 334 Query: 405 EKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA---FPRIFIPAKAVEAAQAHQMA 461 E K K+ +F+++ G+ +G + F ++ IP + Sbjct: 335 E-------YINKFKIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKG 386 Query: 462 PDMFYCMKLLEETGICVVPGSGFGQRE 488 D L+ E G+ +P + F +E Sbjct: 387 KDFRISHWLINELGVVAIPPTEFYIKE 413 >1IJI-A nrPDB Length = 356 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 108/253 (42%), Gaps = 38/253 (15%) Query: 178 PDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDE 237 P+ + ++ GA +GI +++ G + ++ P Y +YS V +E ++ Sbjct: 75 PEQVLVSRGADEGIELLIRAFCEPG---KDAILYCPPTYGMYS-VSAETIGVECRTVPTL 130 Query: 238 ENCWALNVNELRRAVQEAKDHCD-PKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFL 296 +N W L++ Q D D KV+ + +P NPTGQ+ + + ++ K + Sbjct: 131 DN-WQLDL-------QGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELT-RGKAIV 181 Query: 297 LADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYM---GECGYRGGY 353 +ADE Y + + P + EY LA + SK + CG+ Sbjct: 182 VADEAYIE--FCPQASLAGWLA-------EYP---HLAILRTLSKAFALAGLRCGFTLAN 229 Query: 354 MEVINLHPEIKGQLVKLLS-VRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGN 412 EVINL L+K+++ L PV+ AA + VA E Q E+E ++ Sbjct: 230 EEVINL-------LMKVIAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAEREYLIAA 282 Query: 413 LAKKAKLTEDLFN 425 L K+ E +F+ Sbjct: 283 L-KEIPCVEQVFD 294 >3CQ5-A nrPDB Length = 369 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 74/155 (47%), Gaps = 18/155 (11%) Query: 159 IREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPL 218 +R+++AAYIT++ GV DN++ G+++ + +L+ GG RT + P Y + Sbjct: 74 LRDELAAYITKQ-TGVAVTRDNLWAANGSNEILQQLLQAF---GGPGRTALGFQ-PSYSM 128 Query: 219 YSAVI--SELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQV 276 + + + + I V+ D + + E+R AK P ++ + P NPTG V Sbjct: 129 HPILAKGTHTEFIAVSRGADFRIDMDVALEEIR-----AKQ---PDIVFVTTPNNPTGDV 180 Query: 277 QSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDC 311 S +E +I+ A ++ DE Y + SP Sbjct: 181 TSLDDVERIINVA---PGIVIVDEAYAEFSPSPSA 212 >3LY1-A nrPDB Length = 354 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 81/183 (44%), Gaps = 21/183 (11%) Query: 180 NIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP--LYSAVISELDAIQVNYYLDE 237 +I LT G+S+GI ++ S + ++IP Y + A I+ + +V LD Sbjct: 70 SILLTAGSSEGIRAAIEAYASLEAQ----LVIPELTYGDGEHFAKIAGMKVTKVKM-LDN 124 Query: 238 ENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 297 WA ++ L+ AV + P ++ ++NP NPTG + IE I +F++ Sbjct: 125 ---WAFDIEGLKAAVAA---YSGPSIVYLVNPNNPTGTITPADVIEPWIASKPANTMFIV 178 Query: 298 ADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMG-ECGYRGGYMEV 356 DE Y + V P RF S ++ + G E N+ L S G GY + V Sbjct: 179 -DEAYAEFVNDP--RFRSISPMITQ-GAE---NIILLKTFSKIHAMAGMRVGYAVAHPTV 231 Query: 357 INL 359 I L Sbjct: 232 IAL 234 >5Z0Q-C nrPDB Length = 389 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 13/103 (12%) Query: 237 EENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFL 296 E+ W L+++ E + + K+L + NP NP G V RK +E + FA L + Sbjct: 147 EQQRWVLDLDS-----HEDRMSGNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHDLLV 201 Query: 297 LADEVYQDNVYSPDCRFHSF--------KKVLYEMGPEYSSNV 331 +DE++ D V P + F ++ + M P S N+ Sbjct: 202 CSDEIHCDLVLEPGVQHIPFASLSDDAAQRSITLMSPSKSFNI 244 >2ZC0-A nrPDB Length = 407 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 70/339 (20%), Positives = 138/339 (40%), Gaps = 45/339 (13%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ + G+ +RE++AA++ + D + P+NI +T G + + + ++L+ G Sbjct: 71 YTPANGIPELREELAAFLKKYD-HLEVSPENIVITIGGTGALDLLGRVLIDPGD------ 123 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDP-KVLCIIN 268 + I + P Y + + + + + V+ L ++E K K++ I Sbjct: 124 -VVITENPSYINTLLAFEQLGAKIEGVPVDNDGMRVDLLEEKIKELKAKGQKVKLIYTIP 182 Query: 269 PG-NPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 G NP G S + + ++ A + L ++ D Y Y ++ + Sbjct: 183 TGQNPMGVTMSMERRKALLEIASKYDLLIIEDTAYNFMRYEGG-------DIVPLKALDN 235 Query: 328 SSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLC-PPVSGQAAMD 386 V +A S G G+R G+ +I +K L++ + C P +S A++ Sbjct: 236 EGRVIVAGTLSKVLG----TGFRIGW--IIAEGEILKKVLMQKQPIDFCAPAISQYIALE 289 Query: 387 IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIH-CNPLQGAMYAFPRI 445 + FE++ E ++LG K+ + + L N +P P+ G F Sbjct: 290 YL------KRGYFEKYHLEG-ALLGYKEKRDIMLKALENHLPNAEFTKPIAGMFVMF--- 339 Query: 446 FIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGF 484 F+P + A + + +L+E G+ VVPG F Sbjct: 340 FLP----------EGADGISFANELMEREGVVVVPGKPF 368 >1YIY-A nrPDB Length = 429 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 5/69 (7%) Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 W L+ NEL E K++ I P NP G+V R +E V + + + ++DE Sbjct: 168 WVLDNNELEALFNEKT-----KMIIINTPHNPLGKVMDRAELEVVANLCKKWNVLCVSDE 222 Query: 301 VYQDNVYSP 309 VY+ V+ P Sbjct: 223 VYEHMVFEP 231 >3JTX-A nrPDB Length = 396 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDN-IYLTTGASDGISTILKIL---VS 200 + L Y + G+ +R+ A ++ RR G+ D DN I G+ + + + ++ + VS Sbjct: 57 HELEKYPLTAGLPELRQACANWLKRRYDGLTVDADNEILPVLGSREALFSFVQTVLNPVS 116 Query: 201 GGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCD 260 G K ++ P P Y +Y + L ++++ NC A + N R++ E + Sbjct: 117 DGIKP--AIVSPNPFYQIYEGA-TLLGGGEIHF----ANCPAPSFNPDWRSISE-EVWKR 168 Query: 261 PKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 K++ + +P NP+G V ++V + + +DE Y + Sbjct: 169 TKLVFVCSPNNPSGSVLDLDGWKEVFDLQDKYGFIIASDECYSE 212 >2ZY3-A nrPDB Length = 546 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 90/204 (44%), Gaps = 26/204 (12%) Query: 156 VNCIREDVAAYITRRDGG--VPADPDNIYLTTGASDGISTILKIL-VSGGGKSRTGVMIP 212 +N + V YI R G +P++ N++ G + ++ I + L ++G K+ V I Sbjct: 141 LNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGDKVAIG 200 Query: 213 IPQYPLYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPG 270 +P + Y + +++ +V D W +EL + A K+ +NP Sbjct: 201 MPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELDKLKDPAI-----KIFFCVNPS 255 Query: 271 NPTGQVQSRKCIEDVIHFAWEEK--LFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYS 328 NP ++ +E V + E + L +L D+VY ++ D F S L+ + PE + Sbjct: 256 NPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVY--GTFADD--FQS----LFAICPENT 307 Query: 329 SNVELASFHSTSKGYMGECGYRGG 352 V +S SK Y G G+R G Sbjct: 308 LLV-----YSFSK-YFGATGWRLG 325 >4WP0-A nrPDB Length = 472 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 73/194 (37%), Gaps = 24/194 (12%) Query: 125 PSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLT 184 P F +A + A G L Y+ + G + + +A++ G N+ +T Sbjct: 43 PDFAVEAFQHA-----VSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVT 97 Query: 185 TGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQV----------NYY 234 G + T + LV G + V+I P + Y + V N Sbjct: 98 VGGYGALFTAFQALVDEGDE----VIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGE 153 Query: 235 LDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKL 294 L + W L+ EL K K L + P NP G+V SR+ +E V + + Sbjct: 154 LGSSSNWQLDPMEL-----AGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDV 208 Query: 295 FLLADEVYQDNVYS 308 + DEVYQ VY Sbjct: 209 VCITDEVYQWMVYD 222 >1U08-A nrPDB Length = 386 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 86/211 (40%), Gaps = 26/211 (12%) Query: 107 TFLRQVMALCTYPNLLD-SPSFPE-DAKKRARRILQACGGNSLGSYSASQGVNCIREDVA 164 T Q+ AL ++ S FP+ D + + L Y+ GV +RE +A Sbjct: 18 TIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALREAIA 77 Query: 165 AYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVIS 224 R G P +I +T GA++ + + LV G + V+ P Y Y+ I+ Sbjct: 78 QKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDE----VICFDPSYDSYAPAIA 133 Query: 225 ------ELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIIN-PGNPTGQVQ 277 + A+Q ++ + +A ++E R L I+N P NP+ V Sbjct: 134 LSGGIVKRMALQPPHFRVDWQEFAALLSERTR-------------LVILNTPHNPSATVW 180 Query: 278 SRKCIEDVIHFAWEEKLFLLADEVYQDNVYS 308 + + ++F+++DEVY+ +S Sbjct: 181 QQADFAALWQAIAGHEIFVISDEVYEHINFS 211 >3FVS-A nrPDB Length = 422 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 73/194 (37%), Gaps = 24/194 (12%) Query: 125 PSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLT 184 P F +A + A G L Y+ + G + + +A++ G N+ +T Sbjct: 43 PDFAVEAFQHA-----VSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVT 97 Query: 185 TGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQV----------NYY 234 G + T + LV G + V+I P + Y + V N Sbjct: 98 VGGYGALFTAFQALVDEGDE----VIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGE 153 Query: 235 LDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKL 294 L + W L+ EL K K L + P NP G+V SR+ +E V + + Sbjct: 154 LGSSSNWQLDPMEL-----AGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDV 208 Query: 295 FLLADEVYQDNVYS 308 + DEVYQ VY Sbjct: 209 VCITDEVYQWMVYD 222 >1VP4-A nrPDB Length = 425 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 37/185 (20%), Positives = 76/185 (41%), Gaps = 13/185 (7%) Query: 123 DSPSFP-EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 D +FP ++ + A+ I++ +L YS ++G +++ + + R G D DN+ Sbjct: 54 DPETFPRKELAEIAKEIIEKEYHYTL-QYSTTEGDPVLKQQILKLLERMYGITGLDEDNL 112 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 T G+ + I K+ + + P Y I+ N+ + Sbjct: 113 IFTVGSQQALDLIGKLFLDDESYC-------VLDDPAYLGAINAFRQYLANFVVVPLEDD 165 Query: 242 ALNVNELRRAVQEAKDHCDPK----VLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 297 +++N L R + E + K + + N NP G S + + ++ A + LF++ Sbjct: 166 GMDLNVLERKLSEFDKNGKIKQVKFIYVVSNFHNPAGVTTSLEKRKALVEIAEKYDLFIV 225 Query: 298 ADEVY 302 D+ Y Sbjct: 226 EDDPY 230 >3NRA-A nrPDB Length = 407 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 46/206 (22%), Positives = 80/206 (38%), Gaps = 27/206 (13%) Query: 139 LQACGGNSLGSYSASQGV-NCIREDVAAYITRRDGGVPADP-DNIYLTTGASDGISTILK 196 +Q+ G + Y G+ + + +AA+ G P D D + +T G + + Sbjct: 66 VQSGGVQAYTEYRGDLGIRDLLAPRLAAFT-----GAPVDARDGLIITPGTQGALFLAVA 120 Query: 197 ILVSGGGKSRTGVMIPIPQY----PLYSAVISELDAIQVNYYLDEENCWALNVNELRRAV 252 V+ G K V I P Y L E+ +Q++Y +E L++ L A Sbjct: 121 ATVARGDK----VAIVQPDYFANRKLVEFFEGEMVPVQLDYVSADETRAGLDLTGLEEAF 176 Query: 253 QEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCR 312 + +V NP NP G V S + I + A ++AD++Y Y+ Sbjct: 177 K-----AGARVFLFSNPNNPAGVVYSAEEIGQIAALAARYGATVIADQLYSRLRYAGASY 231 Query: 313 FH-------SFKKVLYEMGPEYSSNV 331 H + V+ MGP + ++ Sbjct: 232 THLRAEAAVDAENVVTIMGPSKTESL 257 >2DOU-A nrPDB Length = 376 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 25/48 (52%) Query: 260 DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 + KVL + P NPTG V E+ + A + L+L+ D Y D VY Sbjct: 158 EAKVLLLNYPNNPTGAVADWGYFEEALGLARKHGLWLIHDNPYVDQVY 205 >3T32-A nrPDB Length = 383 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 25/122 (20%), Positives = 56/122 (45%), Gaps = 6/122 (4%) Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYP-LYSAVISELDAIQVNYYLDEENCWALNVN 246 S GI L + K V++ P YP + V + + V+ + + +A++ Sbjct: 88 SAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDTYAIDFE 147 Query: 247 ELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNV 306 L + Q+ K++ + +P NP G+V ++ + + + + ++ADE++ D + Sbjct: 148 HLEKQFQQGV-----KLMLLCSPHNPIGRVWKKEELTKLGSLCTKYNVIVVADEIHSDII 202 Query: 307 YS 308 Y+ Sbjct: 203 YA 204 >4M2J-A nrPDB Length = 406 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 90/381 (23%), Positives = 150/381 (39%), Gaps = 80/381 (20%) Query: 151 SASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVM 210 S SQG +R +A R GG D D + +T G+S+ I+ L L+ G + Sbjct: 81 SVSQGGEGVRRAIA---DRYAGG---DADRVLVTHGSSEAIALTLNALLHRGDR------ 128 Query: 211 IPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNEL-RRAVQEAKDHCDPKVLC---- 265 V+ E + +Y C +V L RAV++ + DP VL Sbjct: 129 ----------VVVQEGIYHSLGHYPRAAGC---DVAVLPGRAVRDGE--IDPDVLAGLVT 173 Query: 266 ------IIN-PGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKK 318 I+N P NPTG S + + + L+ D + + + Sbjct: 174 PGTAAVIVNFPHNPTGVTLSPQGLRALKERTAATGAVLVWDAATAEIAHR--------WE 225 Query: 319 VLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPP 378 VL + G + V S+ + SK + G G R G+ + P+ +LL+ P Sbjct: 226 VLADPGADGGDTV---SYGTLSKTF-GLPGLRVGWA----VAPK------ELLTATF--P 269 Query: 379 VSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAK-----LTEDLFNQVPGIHCN 433 + + + ++P V E E+ R + ++G A +A+ LT + + Sbjct: 270 LRDRTTL--FLSPLV--ELVAERAVRHADELIGARAAEARHNLAHLTGWMAAHEELVRWT 325 Query: 434 PLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHF 493 P +G + A P +F + +E A A + F C++LLE +VPG+ FG G Sbjct: 326 PPEGGVCALP-VF---RELERAAAGPQEVERF-CLELLERHRTLLVPGTAFGAPHGA--- 377 Query: 494 RMTILPPVEKLKTVLQKVKDF 514 R+ P E + L + F Sbjct: 378 RLGFGGPQEDFRAGLDGLSRF 398 >3EI8-A nrPDB Length = 432 Score = 35.0 bits (79), Expect = 0.088, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 87/213 (40%), Gaps = 28/213 (13%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y A QG +R +A GG+ D+++++ GA IS L+++ S + Sbjct: 94 YGAEQGAKPLRAAIAKTFY---GGLGIGDDDVFVSDGAKCDISR-LQVMFG----SNVTI 145 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCD------PKV 263 + P YP Y V S + Q + + + N+ E R E D + Sbjct: 146 AVQDPSYPAY--VDSSVIMGQTGQFNTDVQKYG-NI-EYMRCTPENGFFPDLSTVGRTDI 201 Query: 264 LCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEM 323 + +P NPTG +R+ + ++ FA + ++ D Y +Y D S ++E+ Sbjct: 202 IFFCSPNNPTGAAATREQLTQLVEFAKKNGSIIVYDSAYA--MYMSDDNPRS----IFEI 255 Query: 324 GPEYSSNVELASFHSTSKGYMGECGYRGGYMEV 356 +E ASF + Y G G R G+ + Sbjct: 256 PGAEEVAMETASFSN----YAGFTGVRLGWTVI 284 >1C7O-A nrPDB Length = 399 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 5/98 (5%) Query: 208 GVMIPIP-QYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCI 266 GV+I P YP + A+ ++ I L+++ + ++ +L + ++ + K L Sbjct: 115 GVIIITPVYYPFFMAIKNQERKIIECELLEKDGYYTIDFQKLEKLSKDKNN----KALLF 170 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 +P NP G+V + ++ + + L L +DE++ D Sbjct: 171 CSPHNPVGRVWKKDELQKIKDIVLKSDLMLWSDEIHFD 208 >2ZJG-A nrPDB Length = 410 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 34/142 (23%), Positives = 62/142 (43%), Gaps = 19/142 (13%) Query: 177 DPDN-IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 DP+ I + GA + ++ LV G + V+I +P Y Y ++ A+ V L Sbjct: 83 DPNEEILVAVGAYGSLFNSIQGLVDPGDE----VIIMVPFYDCYEPMVRMAGAVPVFIPL 138 Query: 236 DEE---------NCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVI 286 + + W + EL E+K K + + P NP G+V +R+ ++ + Sbjct: 139 RSKPTDGMKWTSSDWTFDPREL-----ESKFSSKTKAIILNTPHNPLGKVYTRQELQVIA 193 Query: 287 HFAWEEKLFLLADEVYQDNVYS 308 + ++DEVY+ VY+ Sbjct: 194 DLCVKHDTLCISDEVYEWLVYT 215 >3F6T-A nrPDB Length = 533 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 12/84 (14%) Query: 223 ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDP--KVLCIINPGNPTGQVQSRK 280 + + + ++V+ + E+N W + NE+ + DP K L ++NP NPT + Sbjct: 212 LKDYELVEVDLHSYEKNDWEIEPNEIEKL-------KDPSIKALIVVNPTNPTSKEFDTN 264 Query: 281 CIEDVIHFAWEE--KLFLLADEVY 302 + + I A E+ KL +++DEVY Sbjct: 265 AL-NAIKQAVEKNPKLMIISDEVY 287 Score = 31.6 bits (70), Expect = 0.89, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 3/56 (5%) Query: 466 YCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKL---KTVLQKVKDFHINF 518 + +KL E+ G+ +V G GFG + G LP + K VL+ +K+++ F Sbjct: 474 FLLKLAEKNGVVLVDGVGFGAKPGELRVSQANLPTEDYALIGKQVLELLKEYYEEF 529 >3EUC-A nrPDB Length = 367 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 12/119 (10%) Query: 189 DGISTILKILVSGGGKSRTGVMIPIPQYPLY--SAVISELDAIQVNYYLDEENCWALNVN 246 +G I+ +L + VM P+P + +Y SA + L+ + V D + L+ Sbjct: 92 NGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRAD----FTLD-- 145 Query: 247 ELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE--KLFLLADEVYQ 303 R A+ A P ++ + P NPTG + +E ++ A + ++ DE YQ Sbjct: 146 --RGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQGSVCRSLVVVDEAYQ 202 >3EZS-A nrPDB Length = 376 Score = 33.1 bits (74), Expect = 0.27, Method: Compositional matrix adjust. Identities = 40/184 (21%), Positives = 72/184 (39%), Gaps = 21/184 (11%) Query: 122 LDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 ++P F +DA K +SL Y S +R + RR + + + Sbjct: 35 FETPKFIQDALKN--------HTHSLNIYPKSAFEESLRAAQRGFFKRR-FKIELKENEL 85 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 T G+ + + ++ + P P Y +Y + A + L +EN + Sbjct: 86 ISTLGSREVLFNFPSFVLFD--YQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDF 143 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIIN-PGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 ++NE + +QE L I+N P NPTG+ S + + + A + L+ DE Sbjct: 144 TPSLNE--KELQEVD-------LVILNSPNNPTGRTLSLEELISWVKLALKHDFILINDE 194 Query: 301 VYQD 304 Y + Sbjct: 195 CYSE 198 >1D2F-A nrPDB Length = 390 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 51/111 (45%), Gaps = 5/111 (4%) Query: 198 LVSGGGKSRTGVMIPIPQY-PLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAK 256 L+ ++ GV+I P Y Y A+ + + + W ++ +L + AK Sbjct: 103 LIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEKQADGWFCDMGKLEAVL--AK 160 Query: 257 DHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 C +LC +P NPTG+V + +E + + +++DE++ D V+ Sbjct: 161 PECKIMLLC--SPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVW 209 >4FL0-A nrPDB Length = 456 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 42/208 (20%), Positives = 80/208 (38%), Gaps = 24/208 (11%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y QG +R+ +A R + + ++++ GA IS + +L S + Sbjct: 108 YGLEQGNKTLRKAIAETFYRD---LHVKSNEVFVSDGAQSDISRLQLLL-----GSNVTI 159 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDE----ENCWALNVNELRRAVQEAKDHCDPKVLC 265 + P +P Y + S + Q ++ ++ +N + + V+ Sbjct: 160 AVQDPTFPAY--IDSSVIIGQTGHFHEKTKKYQNVVYMPCGPNNSFFPDLAMTPRTDVIF 217 Query: 266 IINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGP 325 +P NPTG V SRK + ++ FA ++ D Y + R +YE+ Sbjct: 218 FCSPNNPTGYVASRKQLHQLVDFAKTNGSIIIFDSAYAAFIEDGSPR------SIYEIPG 271 Query: 326 EYSSNVELASFHSTSKGYMGECGYRGGY 353 +E++SF + G G R G+ Sbjct: 272 AREVAIEVSSFSK----FAGFTGVRLGW 295 >3FTB-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 34/155 (21%), Positives = 62/155 (40%), Gaps = 23/155 (14%) Query: 159 IREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPL 218 + + + Y+ +D G I L GAS+ I + + ++I +P Y Sbjct: 66 LNKSIENYLKLKDIG-------IVLGNGASEIIELSISLF--------EKILIIVPSYAE 110 Query: 219 YSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQS 278 Y + V YLDE C ++ ++ + D + I NP NP G + + Sbjct: 111 YEINAKKHGVSVVFSYLDENMC--IDYEDIISKID------DVDSVIIGNPNNPNGGLIN 162 Query: 279 RKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRF 313 ++ V+ A E+K ++ DE + + P F Sbjct: 163 KEKFIHVLKLAEEKKKTIIIDEAFIEFTGDPSSSF 197 >4DQ6-A nrPDB Length = 391 Score = 32.3 bits (72), Expect = 0.50, Method: Compositional matrix adjust. Identities = 33/155 (21%), Positives = 68/155 (43%), Gaps = 29/155 (18%) Query: 160 REDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLY 219 E + ++ RR IY S G+ + +L++ K+ +MI P Y + Sbjct: 73 NESIVNWLYRRHNWKIKSEWLIY-----SPGVIPAISLLINELTKANDKIMIQEPVYSPF 127 Query: 220 SAV---------ISELDAIQV-NYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 ++V IS L ++ NY +D E+ N+++ D K+ + NP Sbjct: 128 NSVVKNNNRELIISPLQKLENGNYIMDYEDI----ENKIK----------DVKLFILCNP 173 Query: 270 GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 NP G+V ++ ++ + + + +++DE++ D Sbjct: 174 HNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSD 208 >6HNV-A nrPDB Length = 524 Score = 32.3 bits (72), Expect = 0.51, Method: Compositional matrix adjust. Identities = 28/131 (21%), Positives = 56/131 (42%), Gaps = 8/131 (6%) Query: 177 DPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD 236 D N+++TTGASDG++ + + G P ++ +++N+ D Sbjct: 156 DDWNVFITTGASDGLNKAADVFLDDGDVILVEEFTFSPFLRFSDNAGAKAVPVKINFDND 215 Query: 237 EENCWALNVNELRRAVQEAKDHC----DPKVLCIINPG-NPTGQVQSRKCIEDVIHFAWE 291 + +++ + ++ + H PK L I G NPTG QS + + + A + Sbjct: 216 SD---GIDLTQFVDLLENWEKHYPNLPKPKALYTIATGQNPTGFTQSLEFRKKIYDLAVK 272 Query: 292 EKLFLLADEVY 302 ++ D+ Y Sbjct: 273 YDFAIIEDDPY 283 >3FDB-A nrPDB Length = 377 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 22/113 (19%), Positives = 52/113 (46%), Gaps = 9/113 (7%) Query: 195 LKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQE 254 L I + +++ V++P P YP + ++S + ++D +N++++ + Q Sbjct: 94 LYIAIDHFTPAQSKVIVPTPAYPPFFHLLSATQ--REGIFIDATG--GINLHDVEKGFQA 149 Query: 255 AKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 + + + NP NP G V + + + ++ A +L DE++ V+ Sbjct: 150 GA-----RSILLCNPYNPLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVF 197 >4PSP-A nrPDB Length = 585 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 33/142 (23%), Positives = 57/142 (40%), Gaps = 23/142 (16%) Query: 87 FTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNS 146 FT ++ N D I F R Y +L +PED + + G N+ Sbjct: 394 FTAPLQGNSSD--------IRFTRNKEDDVLYVTVL---GWPEDNLVSVKNL----GSNA 438 Query: 147 LGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSR 206 L + + V + + Y+ + D +I L + ++ ++ +LK+ GG Sbjct: 439 LVDLESLKSVELLGDKAGDYVKVSEWEQSKDALDITLPSQPAESLAYVLKLTFDGG---- 494 Query: 207 TGVMIPIPQYPLYSAVISELDA 228 IP+PQ +AV S+ DA Sbjct: 495 ----IPVPQPERGAAVFSKADA 512 >3P1T-A nrPDB Length = 337 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 34/102 (33%), Positives = 45/102 (44%), Gaps = 23/102 (22%) Query: 253 QEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCR 312 Q ++D C + + NP NPTGQ S ++ + A + LL DE Y D Sbjct: 132 QVSRDDC----VVLANPSNPTGQALSAGELDQLRQRAGK----LLIDETYVD-------- 175 Query: 313 FHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYM 354 + SF+ G Y N EL F S SK Y G G R G + Sbjct: 176 YSSFRA----RGLAYGEN-ELV-FRSFSKSY-GLAGLRLGAL 210 >4RAE-A nrPDB Length = 394 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 13/122 (10%) Query: 158 CIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP 217 +R D+A Y+T + G + +NI+ G+++ + +L+ G G+S G +P Y Sbjct: 75 ALRADLAGYLTAQTG-IQLGVENIWAANGSNEILQQLLQAF-GGPGRSAIGF---VPSYS 129 Query: 218 LYSAVISELDAIQVNYY-LDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQV 276 ++ +IS D + N + L+V+ AV + K P V+ I +P NP+GQ Sbjct: 130 MHP-IIS--DGTHTEWIEASRANDFGLDVDVAVAAVVDRK----PDVVFIASPNNPSGQS 182 Query: 277 QS 278 S Sbjct: 183 VS 184 >4RKC-A nrPDB Length = 398 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 73/176 (41%), Gaps = 12/176 (6%) Query: 271 NPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMG-PEYSS 329 NPTG +R+ + V++ E +L D YQ D ++ +K + +MG P + S Sbjct: 183 NPTGVDLTREQWDTVLNVIQERELIPFMDIAYQGFGEDMDSDAYAIRKAV-DMGLPLFVS 241 Query: 330 NVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLL-SVRLCPPVSGQAAMDIV 388 N SF Y G ++ + GQL + + PP G +DIV Sbjct: 242 N----SFSKNLSLYGERVGGLSVVCPTVDETERVFGQLNSTVRRIYSSPPSHGGRVVDIV 297 Query: 389 VNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPL--QGAMYAF 442 +N E+ + ++ + + + KL L ++ G + + L Q M++F Sbjct: 298 MNDAALHEQWVGEVYAMRDRI---KSMRTKLKSVLEAKISGRNFDYLTAQNGMFSF 350 >3DZZ-A nrPDB Length = 391 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 29/133 (21%), Positives = 60/133 (45%), Gaps = 9/133 (6%) Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE 238 D +G IS +++ S G + +++ P Y ++ +VI ++ L E Sbjct: 86 DWCVFASGVVPAISAMVRQFTSPGDQ----ILVQEPVYNMFYSVIEGNGRRVISSDLIYE 141 Query: 239 NC-WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 297 N +++N +L + A V C NP NP G S + ++ + + ++ L+ Sbjct: 142 NSKYSVNWADLEEKL--ATPSVRMMVFC--NPHNPIGYAWSEEEVKRIAELCAKHQVLLI 197 Query: 298 ADEVYQDNVYSPD 310 +DE++ D V + + Sbjct: 198 SDEIHGDLVLTDE 210 >3G7Q-A nrPDB Length = 417 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 38/173 (21%), Positives = 67/173 (38%), Gaps = 31/173 (17%) Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGK 204 ++L +Y QG + A + R G +P NI LT G+ + + Sbjct: 66 DALCNYDGPQG-KTALLNALAVLLRETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRAD 124 Query: 205 SRTG-VMIPI-PQYPLYSAVISELDAI-------------QVNYYLDEENCWALNVNELR 249 T V+ P+ P+Y Y+ E D Q Y++D E+ L++ E Sbjct: 125 GSTKKVLFPLAPEYIGYADSGLEDDLFVSARPNIELLPEGQFKYHVDFEH---LHIGE-- 179 Query: 250 RAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 + ++C+ P NPTG V + + + + A + + L+ D Y Sbjct: 180 ----------ETGMICVSRPTNPTGNVITDEELMKLDRLANQHNIPLVIDNAY 222 >1UU1-A nrPDB Length = 335 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 4/46 (8%) Query: 263 VLCIINPGNPTGQVQSRKCIEDVI----HFAWEEKLFLLADEVYQD 304 V+ I NP NPTG V R+ IE ++ A +E + E Y D Sbjct: 141 VVFIPNPNNPTGHVFEREEIERILKTGAFVALDEAYYEFHGESYVD 186 >1J5Y-A nrPDB Length = 187 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 12/103 (11%) Query: 338 STSKGYMGECGYRGGYMEVINLHP--EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG 395 +T +GY+ G G V H EIK +L LC +G +D++V PV G Sbjct: 69 ATPRGYVLAGGKSGVSRLVAVKHAPEEIKEEL-------LCVVRNGGRIVDVIVEHPVYG 121 Query: 396 E-ESFEQFSREKESV-LGNLAKKAKLTEDLFNQVPGIHCNPLQ 436 E S E+E + NL + AK TE L G+H + ++ Sbjct: 122 EIRGIIDVSSEEEVLKFVNLMEMAK-TEPLLTLSGGVHLHTIE 163 >1LC8-A nrPDB Length = 364 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 61/158 (38%), Gaps = 23/158 (14%) Query: 199 VSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDH 258 V+ G K R MI P + Y +++ + L E + W +L A+ EA Sbjct: 92 VASGLKPRRA-MIVTPGFAEYGRALAQSGCEIRRWSLREADGW-----QLTDAILEALTP 145 Query: 259 CDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKK 318 D L + P NPTG + R ++ + + L+ DE + D + P Sbjct: 146 -DLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEAFID--FIP--------- 193 Query: 319 VLYEMG--PEYSSNVELASFHSTSKGYMGECGYRGGYM 354 +E G P N + S +K Y G R GY+ Sbjct: 194 --HETGFIPALKDNPHIWVLRSLTKFY-AIPGLRLGYL 228 >4RNY-A nrPDB Length = 371 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 4/69 (5%) Query: 295 FLLADEVYQDNVYSPDC--RFHSFKKVLY-EMGPEYSSNVELASFHSTSKGYMGECGYRG 351 FLL V + SP RFH KV G +Y++ + HS S G +G G + Sbjct: 189 FLLETPVKYTRISSPFSYGRFHPVLKVRRPHYGVDYAAK-HGSLIHSASDGRVGFMGVKA 247 Query: 352 GYMEVINLH 360 GY +V+ +H Sbjct: 248 GYGKVVEIH 256 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3IHJ-A nrPDB 629 0.0 3TCM-A nrPDB 479 e-135 1XI9-A nrPDB 344 7e-95 4CVQ-A nrPDB 326 1e-89 1J32-A nrPDB 291 6e-79 1GDE-A nrPDB 286 2e-77 3PDX-A nrPDB 284 5e-77 4MY5-A nrPDB 282 2e-76 6F35-A nrPDB 280 1e-75 3DYD-A nrPDB 279 2e-75 6F77-B nrPDB 278 5e-75 1O4S-A nrPDB 277 5e-75 1GC4-A nrPDB 268 4e-72 5YHV-A nrPDB 264 7e-71 5WMH-A nrPDB 259 2e-69 4IX8-A nrPDB 259 3e-69 2Z61-A nrPDB 259 3e-69 1BW0-A nrPDB 252 3e-67 3H14-A nrPDB 242 3e-64 3QGU-A nrPDB 232 2e-61 2X5D-A nrPDB 232 2e-61 1IAY-A nrPDB 224 9e-59 3B46-A nrPDB 218 5e-57 3ASB-A nrPDB 215 5e-56 2ZC0-A nrPDB 214 9e-56 2GB3-A nrPDB 206 2e-53 1M4N-A nrPDB 200 1e-51 3OP7-A nrPDB 195 3e-50 1V2E-A nrPDB 190 2e-48 3ELE-A nrPDB 187 1e-47 2O0R-A nrPDB 153 1e-37 3B1C-A nrPDB 145 5e-35 5Z0Q-C nrPDB 137 1e-32 2ZY2-A nrPDB 135 4e-32 1IJI-A nrPDB 132 4e-31 3CQ5-A nrPDB 110 2e-24 3LY1-A nrPDB 106 4e-23 Sequences not found previously or not previously below threshold: 4WP0-A nrPDB 184 8e-47 3FVS-A nrPDB 184 1e-46 4FL0-A nrPDB 175 4e-44 1YIY-A nrPDB 173 2e-43 2ZJG-A nrPDB 172 4e-43 1U08-A nrPDB 172 4e-43 3EI8-A nrPDB 170 1e-42 3AV7-A nrPDB 152 4e-37 1X0M-A nrPDB 150 1e-36 3JTX-A nrPDB 144 1e-34 1WST-A nrPDB 143 2e-34 1VP4-A nrPDB 142 3e-34 2O1B-A nrPDB 141 6e-34 3L8A-A nrPDB 136 3e-32 4DQ6-A nrPDB 127 1e-29 2ZY3-A nrPDB 126 2e-29 3NRA-A nrPDB 125 4e-29 3T32-A nrPDB 125 4e-29 4M2J-A nrPDB 125 7e-29 2ZYJ-A nrPDB 121 6e-28 3FDD-A nrPDB 120 1e-27 3FDB-A nrPDB 119 3e-27 3F6T-A nrPDB 117 1e-26 3EZS-A nrPDB 113 3e-25 2DOU-A nrPDB 113 3e-25 1C7O-A nrPDB 109 4e-24 3DZZ-A nrPDB 105 4e-23 1D2F-A nrPDB 102 3e-22 3IF2-A nrPDB 100 3e-21 4GDY-A nrPDB 99 4e-21 6HNV-A nrPDB 98 1e-20 6HNB-A nrPDB 97 2e-20 4JE5-A nrPDB 96 3e-20 3G7Q-A nrPDB 90 3e-18 4EMY-A nrPDB 89 4e-18 3RQ1-A nrPDB 89 5e-18 4RAE-A nrPDB 89 5e-18 4R2N-A nrPDB 88 1e-17 3FTB-A nrPDB 87 2e-17 2X5F-A nrPDB 85 8e-17 3FFH-A nrPDB 83 2e-16 3EUC-A nrPDB 82 7e-16 3G0T-A nrPDB 81 9e-16 1LC8-A nrPDB 77 1e-14 1UU1-A nrPDB 72 6e-13 3FKD-A nrPDB 71 9e-13 3GET-A nrPDB 71 2e-12 4WD2-A nrPDB 68 8e-12 1AY8-A nrPDB 68 9e-12 5X03-B nrPDB 68 1e-11 4N0B-A nrPDB 68 1e-11 3FSL-A nrPDB 68 1e-11 6C3C-A nrPDB 66 4e-11 4RKC-A nrPDB 66 4e-11 3HDO-A nrPDB 66 4e-11 4WB0-B nrPDB 66 5e-11 4WBT-A nrPDB 64 2e-10 3BWN-A nrPDB 62 6e-10 2CST-A nrPDB 61 9e-10 5DJ3-A nrPDB 61 1e-09 3PD6-B nrPDB 60 3e-09 6EZL-A nrPDB 59 4e-09 3MEB-A nrPDB 58 8e-09 4F5M-A nrPDB 58 1e-08 4H51-A nrPDB 57 2e-08 3II0-A nrPDB 57 2e-08 3P1T-A nrPDB 56 3e-08 3K7Y-A nrPDB 54 2e-07 3DR4-A nrPDB 53 3e-07 1YAA-A nrPDB 53 4e-07 4W5K-A nrPDB 52 6e-07 1TAR-A nrPDB 52 7e-07 2C81-A nrPDB 52 7e-07 4W91-A nrPDB 50 3e-06 5TON-A nrPDB 50 3e-06 5C6U-A nrPDB 49 4e-06 3UWC-A nrPDB 49 5e-06 4EFF-A nrPDB 49 7e-06 3VK2-A nrPDB 47 2e-05 4OBV-D nrPDB 47 2e-05 1M6S-A nrPDB 46 3e-05 2HOR-A nrPDB 46 5e-05 2OGE-A nrPDB 45 7e-05 2E7J-A nrPDB 45 1e-04 1O69-A nrPDB 45 1e-04 4L0O-H nrPDB 44 1e-04 5W70-A nrPDB 44 2e-04 5WGB-A nrPDB 43 2e-04 3AEO-A nrPDB 43 3e-04 1CS1-A nrPDB 43 3e-04 6C9E-A nrPDB 42 7e-04 3LVM-A nrPDB 41 0.001 4PIW-A nrPDB 41 0.002 5K8B-A nrPDB 40 0.002 2BWN-A nrPDB 39 0.006 6CJB-A nrPDB 39 0.006 4E3Q-A nrPDB 38 0.008 5IJG-A nrPDB 38 0.009 5VPR-A nrPDB 38 0.013 3I5T-A nrPDB 38 0.015 4IYO-A nrPDB 37 0.016 5JAY-A nrPDB 36 0.034 5KR3-A nrPDB 36 0.036 4BMK-A nrPDB 35 0.081 3NDN-A nrPDB 35 0.084 3A9Z-A nrPDB 35 0.094 4GSA-A nrPDB 34 0.11 3N5M-A nrPDB 34 0.16 4OC9-A nrPDB 34 0.17 1IBJ-A nrPDB 34 0.20 1WA5-C nrPDB 34 0.20 4EB7-A nrPDB 34 0.22 5I92-A nrPDB 33 0.27 5OFN-A nrPDB 33 0.29 2QMA-A nrPDB 33 0.32 3WY7-A nrPDB 33 0.35 3GZD-A nrPDB 33 0.39 5KR5-A nrPDB 33 0.47 1PL8-A nrPDB 32 0.58 6C55-A nrPDB 32 0.75 5LH9-A nrPDB 31 0.90 6EEW-A nrPDB 31 0.95 2GRU-A nrPDB 31 1.2 6JEQ-A nrPDB 31 1.4 6CBN-A nrPDB 31 1.6 4RIT-B nrPDB 31 1.8 4EQ5-A nrPDB 30 2.0 4UHN-A nrPDB 30 2.8 4JBE-A nrPDB 30 2.9 2DHM-A nrPDB 29 3.3 4WQ5-A nrPDB 29 5.7 >3IHJ-A nrPDB Length = 498 Score = 629 bits (1621), Expect = 0.0, Method: Composition-based stats. Identities = 475/476 (99%), Positives = 476/476 (100%) Query: 48 LTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT 107 +TLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT Sbjct: 23 MTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPIT 82 Query: 108 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI 167 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI Sbjct: 83 FLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI 142 Query: 168 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD 227 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD Sbjct: 143 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELD 202 Query: 228 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH Sbjct: 203 AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 262 Query: 288 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 347 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC Sbjct: 263 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 322 Query: 348 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE 407 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE Sbjct: 323 GYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKE 382 Query: 408 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 467 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC Sbjct: 383 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 442 Query: 468 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA 523 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA Sbjct: 443 MKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA 498 >3TCM-A nrPDB Length = 500 Score = 479 bits (1233), Expect = e-135, Method: Composition-based stats. Identities = 212/482 (43%), Positives = 317/482 (65%), Gaps = 13/482 (2%) Query: 48 LTLESMNPQVKAVEYAVRGPIVLKAGEIE--LELQRGIKKPFTEVIRANIGDAQAMGQQP 105 + ++++NP+V EYAVRG IV+ A ++ L+ Q G PF E++ NIG+ Q++GQQP Sbjct: 23 VAVDNLNPKVLKCEYAVRGEIVIHAQRLQEQLKTQPG-SLPFDEILYCNIGNPQSLGQQP 81 Query: 106 ITFLRQVMALCTYPNLLDSPS----FPEDAKKRARRILQACGGNSLGSYSASQGVNCIRE 161 +TF R+V+ALC +P+LL F D+ RA++IL G + G+YS SQG++ +R+ Sbjct: 82 VTFFREVLALCDHPDLLQREEIKTLFSADSISRAKQILAMIPGRATGAYSHSQGIHGLRD 141 Query: 162 DVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSA 221 +A+ I RDG PA+ D+I+LT GAS G+ ++++L+ + G+++PIPQYPLYSA Sbjct: 142 AIASGIASRDG-FPANADDIFLTDGASPGVHLMMQLLIR---NEKDGILVPIPQYPLYSA 197 Query: 222 VISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHC-DPKVLCIINPGNPTGQVQSRK 280 I+ V YYL+E W L +++++ +++A+ + + L +INPGNPTGQV + + Sbjct: 198 SIALHGGALVPYYLNESTGWGLETSDVKKQLEDARSRGINVRALVVINPGNPTGQVLAEE 257 Query: 281 CIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTS 340 D++ F E L LLADEVYQ+N+Y + +FHSFKK++ +G ++ L S+ S S Sbjct: 258 NQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKIVRSLGY-GEEDLPLVSYQSVS 316 Query: 341 KGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFE 400 KGY GECG RGGY E+ ++ Q+ K+ SV LC ++GQ +V+NPP A +ES+ Sbjct: 317 KGYYGECGKRGGYFEITGFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKASDESYA 376 Query: 401 QFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQM 460 + EK+ +L +LA++AK E FN++ GI CN +GAMY FP+I +P KA+EAA+A Sbjct: 377 SYKAEKDGILASLARRAKALEHAFNKLEGITCNEAEGAMYVFPQICLPQKAIEAAKAANK 436 Query: 461 APDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLE 520 APD FY ++LLE TGI VVPGSGFGQ GT+HFR TILP +K+ V+ + FH F+ Sbjct: 437 APDAFYALRLLESTGIVVVPGSGFGQVPGTWHFRCTILPQEDKIPAVISRFTVFHEAFMS 496 Query: 521 KY 522 +Y Sbjct: 497 EY 498 >1XI9-A nrPDB Length = 406 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 116/470 (24%), Positives = 208/470 (44%), Gaps = 82/470 (17%) Query: 56 QVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMAL 115 + +VEYA+R +VL A E+E ++GIK VIR NIGD QP Sbjct: 15 RALSVEYAIRD-VVLPARELE---KKGIK-----VIRLNIGDPVKFDFQP---------- 55 Query: 116 CTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVP 175 PE K+ + ++ Y S+G+ +R+ + +R GV Sbjct: 56 ------------PEHMKEAYCKAIKE----GHNYYGDSEGLPELRKAIVER-EKRKNGVD 98 Query: 176 ADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 PD++ +T ++ + I L+ G + +++P P YP Y+ ++ V Y Sbjct: 99 ITPDDVRVTAAVTEALQLIFGALLDPGDE----ILVPGPSYPPYTGLVKFYGGKPVEYRT 154 Query: 236 DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 EE W +++++R+ + + K + +INP NPTG + +K +E++++ A E ++ Sbjct: 155 IEEEDWQPDIDDIRKKITD-----RTKAIAVINPNNPTGALYDKKTLEEILNIAGEYEIP 209 Query: 296 LLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 +++DE+Y Y + + + +V + + SK Y G+R GYM Sbjct: 210 VISDEIYDLMTYEGE----------HISPGSLTKDVPVIVMNGLSKVYFA-TGWRLGYMY 258 Query: 356 VINL---HPEIKGQLVKLLSVRLCPPVSGQ-AAMDIVVNPPVAGEESFEQFSREKESVLG 411 ++ E++ + +L +RLCP Q AA+ + P +E ++ ++ + Sbjct: 259 FVDPENKLSEVREAIDRLARIRLCPNTPAQFAAIAGLTGPMDYLKEYMKKLKERRDYIYK 318 Query: 412 NLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLL 471 L N++PGI QGA Y FP+I + D + + +L Sbjct: 319 RL-----------NEIPGISTTKPQGAFYIFPKI----------EVGPWKNDKEFVLDVL 357 Query: 472 EETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEK 521 + V GSGFG+ G HFR LPP+E L+ + + + F L++ Sbjct: 358 HNAHVLFVHGSGFGE-YGAGHFRAVFLPPIEILEEAMDRFEKFMKERLKE 406 >4CVQ-A nrPDB Length = 431 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 115/466 (24%), Positives = 202/466 (43%), Gaps = 75/466 (16%) Query: 56 QVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMAL 115 +++ V Y +RGP++ +A +E E + V++ NIG+ G Sbjct: 35 KLENVCYDIRGPVLKEAKRLEEEGNK--------VLKLNIGNPAPFG------------- 73 Query: 116 CTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVP 175 D+P E R + A G Y S+G+ R+ + + R G Sbjct: 74 ------FDAPD--EILVDVIRNLPTAQG------YCDSKGLYSARKAIMQHYQAR-GMRD 118 Query: 176 ADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 ++IY+ G S+ I ++ L++ G + +++P P YPL++A +S V+Y Sbjct: 119 VTVEDIYIGNGVSELIVQAMQALLNSGDE----MLVPAPDYPLWTAAVSLSSGKAVHYLC 174 Query: 236 DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 DE + W +++++R + + + IINP NPTG V S++ + +++ A + L Sbjct: 175 DESSDWFPDLDDIRAKITP-----RTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLI 229 Query: 296 LLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 + ADE+Y +Y D HS + ++ +F+ SK Y G+R G+M Sbjct: 230 IFADEIYDKILYD-DAEHHSIAPLAP--------DLLTITFNGLSKTYRV-AGFRQGWMV 279 Query: 356 VINLHPEIKGQ---LVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGN 412 + KG L L S+RLC V Q A+ + G +S +F G Sbjct: 280 LNGPKKHAKGYIEGLEMLASMRLCANVPAQHAI----QTALGGYQSISEFITPG----GR 331 Query: 413 LAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLE 472 L ++ +L N +PG+ C +GA+Y FP+I A+ + D + L Sbjct: 332 LYEQRNRAWELINDIPGVSCVKPRGALYMFPKI--------DAKRFNIHDDQKMVLDFLL 383 Query: 473 ETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINF 518 + + +V G+ F HFR+ LP V+ ++ L K F + Sbjct: 384 QEKVLLVQGTAFNW-PWPDHFRIVTLPRVDDIELSLSKFARFLSGY 428 >1J32-A nrPDB Length = 388 Score = 291 bits (743), Expect = 6e-79, Method: Composition-based stats. Identities = 83/393 (21%), Positives = 158/393 (40%), Gaps = 50/393 (12%) Query: 124 SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 P F P+ + A+ L+ Y + G +RE +A + RD G+ DNI Sbjct: 39 EPDFNTPKHIVEAAKAALE----QGKTRYGPAAGEPRLREAIAQKLQ-RDNGLCYGADNI 93 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 +T G I ++ ++ G + V+IP P + Y ++ + V E + Sbjct: 94 LVTNGGKQSIFNLMLAMIEPGDE----VIIPAPFWVSYPEMVKLAEGTPVILPTTVETQF 149 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 ++ ++R+A+ K+L P NPTG V + + + A E L++L+DE+ Sbjct: 150 KVSPEQIRQAITPKT-----KLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVLSDEI 204 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y+ +Y D + S E Y +V + F T G+R G++ Sbjct: 205 YEKILYD-DAQHLSIGAASPE---AYERSVVCSGFAKT----YAMTGWRVGFLAGPVPL- 255 Query: 362 EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTE 421 V+ + G + ++ ++E + +L A++ + Sbjct: 256 -----------VKAATKIQGHSTSNVCTFAQYGAIAAYENSQDCVQEMLAAFAERRRYML 304 Query: 422 DLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG 481 D N +PG+ C GA Y FP I A + +C +LL++ + VPG Sbjct: 305 DALNAMPGLECPKPDGAFYMFPSI-----------AKTGRSSLDFCSELLDQHQVATVPG 353 Query: 482 SGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 + FG + R++ ++ +K +++++ F Sbjct: 354 AAFGADDC---IRLSYATDLDTIKRGMERLEKF 383 >1GDE-A nrPDB Length = 389 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 94/393 (23%), Positives = 166/393 (42%), Gaps = 49/393 (12%) Query: 124 SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPD-N 180 P F P+ K+ A+ L L Y + G+ +RE +A + ++ G+ ADP Sbjct: 35 EPDFDTPQHIKEYAKEALD----KGLTHYGPNIGLLELREAIAEKLKKQ-NGIEADPKTE 89 Query: 181 IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC 240 I + GA+ L + G + V+IP P + Y+ + V EE+ Sbjct: 90 IMVLLGANQAFLMGLSAFLKDGEE----VLIPTPAFVSYAPAVILAGGKPVEVPTYEEDE 145 Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 + LNV+EL++ V + + L I +P NPTG V ++K +E++ F E L +++DE Sbjct: 146 FRLNVDELKKYVTDKT-----RALIINSPCNPTGAVLTKKDLEEIADFVVEHDLIVISDE 200 Query: 301 VYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLH 360 VY+ +Y D R +S + + + + F T G+R G++ + Sbjct: 201 VYEHFIYD-DARHYSIA----SLDGMFERTITVNGFSKT----FAMTGWRLGFVAAPSW- 250 Query: 361 PEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLT 420 I ++VK PV+ + A E+ + E + ++ KL Sbjct: 251 --IIERMVKFQMYNATCPVT-------FIQYAAAKALKDERSWKAVEEMRKEYDRRRKLV 301 Query: 421 EDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVP 480 N++ G+ +GA Y FPRI + +L+E + VVP Sbjct: 302 WKRLNEM-GLPTVKPKGAFYIFPRIRDTGL-----------TSKKFSELMLKEARVAVVP 349 Query: 481 GSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 GS FG + G + R++ EKL+ + +++ Sbjct: 350 GSAFG-KAGEGYVRISYATAYEKLEEAMDRMER 381 >3PDX-A nrPDB Length = 402 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 103/441 (23%), Positives = 176/441 (39%), Gaps = 72/441 (16%) Query: 86 PFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGN 145 P VI +IGD G + P+ PE + + L + N Sbjct: 29 PNKTVISLSIGDPTVFG--------------------NLPTDPE-VTQAMKDALDSGKYN 67 Query: 146 SLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKS 205 Y+ S G RE+VA+Y + P + ++ LT+G S I L +L + G Sbjct: 68 G---YAPSIGYLSSREEVASYYHCPEA--PLEAKDVILTSGCSQAIELCLAVLANPG--- 119 Query: 206 RTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLC 265 ++IP P + LY + + Y L E W +++ +L + E L Sbjct: 120 -QNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTAC-----LV 173 Query: 266 IINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGP 325 + NP NP G V S++ ++ ++ A + + +LADE+Y D V+S DC+ YE Sbjct: 174 VNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFS-DCK--------YEPMA 224 Query: 326 EYSSNVELASFHSTSKGYMGECGYRGGYMEVIN----LHPEIKGQLVKLLSVRLCPPVSG 381 S+NV + S +K ++ G+R G++ + + EI+ LVKL L P Sbjct: 225 TLSTNVPILSCGGLAKRWLV-PGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIV 283 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 Q A+ ++ + L L A L + +PG+ GAMY Sbjct: 284 QGALKSILQ---------RTPQEFYQDTLSFLKSNADLCYGALSAIPGLQPVRPSGAMYL 334 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPV 501 I E + D+ + +L+ E + +P + F E FR+ I P Sbjct: 335 MVGI-------EMEHFPEFENDVEFTERLIAEQSVHCLPATCF---EYPNFFRVVITVPE 384 Query: 502 EKLKTVLQKVKDFHINFLEKY 522 + ++++F E++ Sbjct: 385 VMMLEACSRIQEF----CEQH 401 >4MY5-A nrPDB Length = 393 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 90/428 (21%), Positives = 181/428 (42%), Gaps = 63/428 (14%) Query: 106 ITFLRQV-MALCTYPNLLD----SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNC 158 ++ +RQ ++ P++L P F P+ K+ A+R + A + Y+ G+ Sbjct: 18 VSMIRQFDQSISDIPDVLKLTLGEPDFATPKHIKEAAKRAIDADESH----YTGMAGLLA 73 Query: 159 IREDVAAYITRRDGGVPADPDN-IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP 217 +R+ +A++ + + +PDN I +T GA++ +S L ++ G K V++P P YP Sbjct: 74 LRQAASAFVKEKY-HLTYNPDNEILVTIGATEALSASLTAILEPGDK----VLLPAPAYP 128 Query: 218 LYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQ 277 Y V++ + A V N + L L A+ K+ K + + P NPTG Sbjct: 129 GYEPVVNLVGAEVVEIDTR-SNDFVLTPEMLEEAI--LKEGEALKAVILNYPTNPTGVTY 185 Query: 278 SRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFH 337 SR+ I+++ + +F+++DEVY + Y+ + + E P+ + + Sbjct: 186 SRQQIKNLAEVLKKYPIFVISDEVYAELTYTGESHV-----SIAEYLPDQTILI-----S 235 Query: 338 STSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ--AAMDIVVNPPVAG 395 SK + G+R G +I + QL+K + + AA++ + N Sbjct: 236 GLSKSH-AMTGWRLG---LIFAPAVLTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDDA 291 Query: 396 EESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAA 455 E++ + ++ ++ + GA Y F +I + Sbjct: 292 LPMKEEYIKRRDYIIEKMEAMK------------FKIIKPDGAFYIFAKIPV-------- 331 Query: 456 QAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFH 515 Q + +E + +PG FG + G + R++ +E +K ++++K+F Sbjct: 332 --AQGQDSFKFLQDFAKEKAVAFIPGVAFG-KYGEGYLRISYAASMETIKEAMKRLKEF- 387 Query: 516 INFLEKYA 523 +E+YA Sbjct: 388 ---MEQYA 392 >6F35-A nrPDB Length = 410 Score = 280 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 91/431 (21%), Positives = 163/431 (37%), Gaps = 41/431 (9%) Query: 85 KPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGG 144 +P + + + + +G + R+ + PE K+ A + Sbjct: 13 QPASRISSIGVSEILKIGARAAAMKREGKPVIILGAGEPDFDTPEHVKQAASDAI----H 68 Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGK 204 Y+A G +++ + R+ G+ + D I + TGA + + + G + Sbjct: 69 RGETKYTALDGTPELKKAIREKFQ-RENGLAYELDEITVATGAKQILFNAMMASLDPGDE 127 Query: 205 SRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVL 264 V+IP P + YS ++ + V D + + L +L A+ + + Sbjct: 128 ----VIIPTPYWTSYSDIVHICEGKPVLIACDASSGFRLTAEKLEAAITP-----RTRWV 178 Query: 265 CIINPGNPTGQVQSRKCIEDVIHFAWEE-KLFLLADEVYQDNVYSPDCRFHSFKKVLYEM 323 + +P NP+G S ++ ++LL D++Y+ VY F E Sbjct: 179 LLNSPSNPSGAAYSAADYRPLLEVLLRHPHVWLLVDDMYEHIVYDG---FRFVTPAQLEP 235 Query: 324 GPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQA 383 G + + + + SK Y G+R GY IK V CP QA Sbjct: 236 GLKNRT----LTVNGVSKAY-AMTGWRIGY--AGGPRELIKAMAVVQSQATSCPSSISQA 288 Query: 384 AMDIVVNPPVAG-EESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAF 442 A + +N P +E E F R ++ V+ L N + G+ C +GA Y F Sbjct: 289 ASVVALNGPQDFLKERTESFQRRRDLVVNGL-----------NAIDGLDCRVPEGAFYTF 337 Query: 443 PRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVE 502 V + ++ D +C LLE+ + VVPGS FG + FR++ Sbjct: 338 SGCAGVLGKVTPS-GKRIKTDTDFCAYLLEDAHVAVVPGSAFGL---SPFFRISYATSEA 393 Query: 503 KLKTVLQKVKD 513 +LK L+++ Sbjct: 394 ELKEALERIAA 404 >3DYD-A nrPDB Length = 427 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 99/441 (22%), Positives = 176/441 (39%), Gaps = 72/441 (16%) Query: 86 PFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGN 145 P +I +IGD G + P+ PE + + L + N Sbjct: 52 PNKTMISLSIGDPTVFG--------------------NLPTDPE-VTQAMKDALDSGKYN 90 Query: 146 SLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKS 205 Y+ S G RE++A+Y + P + ++ LT+G S I L +L + G Sbjct: 91 G---YAPSIGFLSSREEIASYYHCPEA--PLEAKDVILTSGCSQAIDLCLAVLANPG--- 142 Query: 206 RTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLC 265 +++P P + LY + + Y L E W +++ +L + E L Sbjct: 143 -QNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTAC-----LI 196 Query: 266 IINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGP 325 + NP NP G V S++ ++ ++ A + + +LADE+Y D V+S DC+ YE Sbjct: 197 VNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFS-DCK--------YEPLA 247 Query: 326 EYSSNVELASFHSTSKGYMGECGYRGGYMEVIN----LHPEIKGQLVKLLSVRLCPPVSG 381 S++V + S +K ++ G+R G++ + + EI+ LVKL L P Sbjct: 248 TLSTDVPILSCGGLAKRWLV-PGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIV 306 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 Q A+ ++ E + + L L A L +PG+ GAMY Sbjct: 307 QGALKSIL-----CRTPGEFY----HNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYL 357 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPV 501 I E + D+ + +L+ E + +P + F E R+ I P Sbjct: 358 MVGI-------EMEHFPEFENDVEFTERLVAEQSVHCLPATCF---EYPNFIRVVITVPE 407 Query: 502 EKLKTVLQKVKDFHINFLEKY 522 + ++++F E++ Sbjct: 408 VMMLEACSRIQEF----CEQH 424 >6F77-B nrPDB Length = 400 Score = 278 bits (710), Expect = 5e-75, Method: Composition-based stats. Identities = 84/399 (21%), Positives = 155/399 (38%), Gaps = 51/399 (12%) Query: 124 SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 P F P++ KK A + Y+ G+ +RE +A +R+ + Sbjct: 40 EPDFDTPDNIKKAAIDAID----RGETKYTPVSGIPELREAIAKKF-KRENNLDYTAAQT 94 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 + TG + ++ G + V+IP P + Y +++ V +EN + Sbjct: 95 IVGTGGKQILFNAFMATLNPGDE----VVIPAPYWVSYPEMVALCGGTPVFVPTRQENNF 150 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE-KLFLLADE 300 L +L RA+ K +P NP+G S + ++ + + +++L D+ Sbjct: 151 KLKAEDLDRAITPKT-----KWFVFNSPSNPSGAAYSHEELKALTDVLMKHPHVWVLTDD 205 Query: 301 VYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGY----MEV 356 +Y+ Y D RF + +V E + + SK Y G+R GY + + Sbjct: 206 MYEHLTY-GDFRFATPVEV------EPGLYERTLTMNGVSKAY-AMTGWRIGYAAGPLHL 257 Query: 357 INLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKK 416 I I+GQ ++ AA++ + P + E F ++ V+ Sbjct: 258 IKAMDMIQGQ-----QTSGAASIAQWAAVEALNGPQDFIGRNKEIFQGRRDLVV------ 306 Query: 417 AKLTEDLFNQVPGIHCNPLQGAMYAFPRIF-IPAKAVEAAQAHQMAPDMFYCMKLLEETG 475 + NQ GI C +GA Y +P + K + + + D + +LLE G Sbjct: 307 -----SMLNQAKGISCPTPEGAFYVYPSCAGLIGKTAPSGKV--IETDEDFVSELLETEG 359 Query: 476 ICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 + VV GS FG FR++ L+ ++++ F Sbjct: 360 VAVVHGSAFGLGPN---FRISYATSEALLEEACRRIQRF 395 >1O4S-A nrPDB Length = 389 Score = 277 bits (709), Expect = 5e-75, Method: Composition-based stats. Identities = 81/393 (20%), Positives = 144/393 (36%), Gaps = 59/393 (15%) Query: 124 SPSFP--EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 P FP E + A R LQ Y+ +G+ +RE +A I R PD + Sbjct: 50 EPDFPTPEPVVEEAVRFLQ----KGEVKYTDPRGIYELREGIAKRIGERYKK-DISPDQV 104 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 +T GA + L+ G + V++ P + Y I + Sbjct: 105 VVTNGAKQALFNAFMALLDPGDE----VIVFSPVWVSYIPQIILAGGTVNVVETFMSKNF 160 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 ++ E+ + K + I +P NPTG V R+ +E ++ A + ++++DEV Sbjct: 161 QPSLEEVEGLLV-----GKTKAVLINSPNNPTGVVYRREFLEGLVRLAKKRNFYIISDEV 215 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y VY+ + + ++ + V + F + G+R GY+ Sbjct: 216 YDSLVYTDEFT------SILDVSEGFDRIVYINGFSKS----HSMTGWRVGYLI----SS 261 Query: 362 EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTE 421 E V + ++ A + V + F K V+ L K Sbjct: 262 EKVATAVSKIQSHTTSCINTVAQYAALKALEVDNSYMVQTFKERKNFVVERLKKM----- 316 Query: 422 DLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG 481 G+ +GA Y F ++ D+ +C +LLEE + +VPG Sbjct: 317 -------GVKFVEPEGAFYLFFKV--------------RGDDVKFCERLLEEKKVALVPG 355 Query: 482 SGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 S F + R++ +E+L L +++DF Sbjct: 356 SAFLK---PGFVRLSFATSIERLTEALDRIEDF 385 >1GC4-A nrPDB Length = 385 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 84/399 (21%), Positives = 149/399 (37%), Gaps = 67/399 (16%) Query: 124 SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 P F PE K+ ARR L Y+ G+ +RE +A RR+ G+ P+ Sbjct: 40 EPDFDTPEHVKEAARRAL----AQGKTKYAPPAGIPELREALAEKF-RRENGLSVTPEET 94 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 +T G S + + + ++ G + V++ P + Y ++ + V E + Sbjct: 95 IVTVGGSQALFNLFQAILDPGDE----VIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGF 150 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 + +RRA+ K L + +P NPTG V ++ +E + A E +L++DE+ Sbjct: 151 VPDPERVRRAITP-----RTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEI 205 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGY----MEVI 357 Y+ +Y + P + + + +K G+R GY EVI Sbjct: 206 YEHLLYEGE-----------HFSPGRVAPEHTLTVNGAAKA-FAMTGWRIGYACGPKEVI 253 Query: 358 NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG---EESFEQFSREKESVLGNLA 414 + Q S ++ A ++ + N + E + E + R ++ +L L Sbjct: 254 KAMASVSRQ-----STTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLT 308 Query: 415 KKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 474 G+ GA Y +APD + L E Sbjct: 309 AL------------GLKAVRPSGAFYVL------------MDTSPIAPDEVRAAERLLEA 344 Query: 475 GICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 G+ VVPG+ F H R++ E L+ L++ Sbjct: 345 GVAVVPGTDF---AAFGHVRLSYATSEENLRKALERFAR 380 >5YHV-A nrPDB Length = 394 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 81/387 (20%), Positives = 143/387 (36%), Gaps = 48/387 (12%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGA 187 PE + A L YS + G+ +R+ +AA RR G + +PD + +TTG+ Sbjct: 52 PEPVRAAAAAALHLNQL----GYSVALGIPELRDAIAADYQRRHG-ITVEPDAVVITTGS 106 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 S G G + V + P YP Y ++S L V + + Sbjct: 107 SGGFLLAFLACFDAGDR----VAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQM 162 Query: 248 LRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 L + + + +P NPTG V + + + + + L++DEVY VY Sbjct: 163 LAE------IDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVY 216 Query: 308 SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL 367 + + ++ +S SK Y G+R G++ V + L Sbjct: 217 QG----------APQTSCAWQTSRNAVVVNSFSK-YYAMTGWRLGWLLVPTVLRRAVDCL 265 Query: 368 VKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQV 427 + +CPPV Q A P + + E + L + A L D ++ Sbjct: 266 T--GNFTICPPVLSQIAAVSAFTP---------EATAEADGNLASYAINRSLLLDGLRRI 314 Query: 428 PGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQR 487 P GA Y + + + + + +C KLL +TG+ + PG F Sbjct: 315 GIDRLAPTDGAFYVYADV-----------SDFTSDSLAFCSKLLADTGVAIAPGIDFDTA 363 Query: 488 EGTYHFRMTILPPVEKLKTVLQKVKDF 514 G R++ P ++ L+++ + Sbjct: 364 RGGSFVRISFAGPSGDIEEALRRIGSW 390 >5WMH-A nrPDB Length = 475 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 92/502 (18%), Positives = 188/502 (37%), Gaps = 51/502 (10%) Query: 23 SQSSAAAEASAVLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRG 82 SQSS A +SA + ++ I ++ P + Y G + + I + Sbjct: 3 SQSSVAVISSAAARGESFPDSKKPIGSVRFQQPLRLSFSYCKSGNM---SSRICAMAKPN 59 Query: 83 IKKPFTEVIRANIGDAQAMGQQP-----ITFLRQVMALCTYPNL---LDSPSF--PEDAK 132 + + + ++ + +P IT L + P + P F P+ Sbjct: 60 DAETLSSSVDMSL-SPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVA 118 Query: 133 KRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGIS 192 + ++ Y+ + G+ +RE + + + + G+ PD I ++ GA + Sbjct: 119 EAGINAIRE----GFTRYTLNAGITELREAICRKL-KEENGLSYAPDQILVSNGAKQSLL 173 Query: 193 TILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAV 252 + + S G + V+IP P + Y+ DA V N + L+ +L + Sbjct: 174 QAVLAVCSPGDE----VIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKL 229 Query: 253 QEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH-FAWEEKLFLLADEVYQDNVYSPDC 311 E ++L + +P NPTG V + +E++ A +L +L+DE+Y+ +Y+P Sbjct: 230 TEKS-----RLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAP-A 283 Query: 312 RFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLL 371 SF + Y + + F GY G ++ +++GQ+ Sbjct: 284 THTSFA----SLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGA 339 Query: 372 SVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIH 431 S ++ +A + + GE E ++ ++ + G+ Sbjct: 340 S-----SIAQKAGVAALGLGKAGGETVAE--------MVKAYRERRDFLVKSLGDIKGVK 386 Query: 432 CNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTY 491 + QGA Y F F EA + + L++ + +VPG FG Sbjct: 387 ISEPQGAFYLFID-FSAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC-- 443 Query: 492 HFRMTILPPVEKLKTVLQKVKD 513 R++ ++ L+ ++K++ Sbjct: 444 -IRISYATSLDVLQAAVEKIRK 464 >4IX8-A nrPDB Length = 444 Score = 259 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 90/433 (20%), Positives = 163/433 (37%), Gaps = 49/433 (11%) Query: 94 NIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSAS 153 N+ D + + LR + T L +P ++ Y + Sbjct: 55 NLTDNMKPSRSTKSNLRLSIGDPTVDGNLKTPDI------VTEAMVDVVRSGKFNGYPPT 108 Query: 154 QGVNCIREDVAAYITR----RDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 G + +R+ V+ Y R + +N+ +T+G S I L L + G + Sbjct: 109 VGADNLRQVVSTYWRRFCQTKSRQEALKWENVIITSGVSQAIVLALTALCNEGDN----I 164 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 ++ P +P Y +V YYLD W ++ V K IINP Sbjct: 165 LVCAPSFPHYKSVCDSYGIECRYYYLDPSKSWECDLRAAAGMVD-----SHTKAFVIINP 219 Query: 270 GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSS 329 NP G SR + D+I F + ++ L++DE+Y + V ++ ++ + Sbjct: 220 SNPCGSNFSRAHVSDIIDFCQQHQIPLISDEIYAEMV---------LNNGIFTSVADFDT 270 Query: 330 NVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVV 389 NV T+K Y G+R G+ +I+ V + RL + A ++ + Sbjct: 271 NVPRLILGGTAK-YQVCPGWRVGWSILIDPMNVAGDWAVGM--ERLTQLI---AGVNSIC 324 Query: 390 NPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPA 449 +A + + E ++ L AK+ L GI Q +M+ ++ + Sbjct: 325 QEAIA-RTLLKCPTECTEHIVTQLEAGAKVYARLLEHDIGISMEAPQASMFVMLKLNL-- 381 Query: 450 KAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQ 509 + + DM + KLL+E + V+PG FG + R T+ P L + Sbjct: 382 -----SYFQDLKSDMEFYEKLLDEENVQVLPGEIFGM---SGFLRATVSRPSAVLNEAVD 433 Query: 510 KVKDFHINFLEKY 522 ++ I F E++ Sbjct: 434 RI----IEFCERH 442 >2Z61-A nrPDB Length = 370 Score = 259 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 93/395 (23%), Positives = 155/395 (39%), Gaps = 69/395 (17%) Query: 124 SPSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 P F P+ + L+ Y+ S+G+ +RE ++ + PDNI Sbjct: 38 EPDFNTPKPIVDEGIKSLKE----GKTHYTDSRGILELREKISELYKDKY-KADIIPDNI 92 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 +T G+S G+ L ++ G + V+I P YP Y I L A V + D Sbjct: 93 IITGGSSLGLFFALSSIIDDGDE----VLIQNPCYPCYKNFIRFLGAKPV--FCD----- 141 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 V L A+ + K + I +P NP G+V R+ + FA+E ++++DE+ Sbjct: 142 -FTVESLEEALSDKT-----KAIIINSPSNPLGEVIDRE----IYEFAYENIPYIISDEI 191 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y VY C E+ N+E + G+R GY+ + Sbjct: 192 YNGLVYEGKCY----------SAIEFDENLEKTILINGFSKLYAMTGWRIGYVI---SND 238 Query: 362 EIKGQLVKLLSVRL--CPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 EI ++KL P +S AA+ ++ RE S++ ++ +L Sbjct: 239 EIIEAILKLQQNLFISAPTISQYAALKAFE----------KETEREINSMIKEFDRRRRL 288 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 NP+ GA Y FP I + KLL+E + + Sbjct: 289 VLKYVKDFGWEVNNPI-GAYYVFPNIG--------------EDGREFAYKLLKEKFVALT 333 Query: 480 PGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 PG GFG + G + R++ E +K L+++K+F Sbjct: 334 PGIGFGSK-GKNYIRISYANSYENIKEGLERIKEF 367 >1BW0-A nrPDB Length = 416 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 99/470 (21%), Positives = 185/470 (39%), Gaps = 80/470 (17%) Query: 66 GPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSP 125 G + + + +I+ ++GD + + +T Q+ Sbjct: 13 GLVFNPIRTVSDNAKPSPSP--KPIIKLSVGDP-TLDKNLLTSAAQI------------- 56 Query: 126 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYI-----TRRDGGVPADPDN 180 K+ + + + N Y + G RE VA + + + DN Sbjct: 57 -------KKLKEAIDSQECNG---YFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDN 106 Query: 181 IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC 240 + L +G S GI + + G + ++P P +P Y V Y EN Sbjct: 107 VVLCSGGSHGILMAITAICDAGDYA----LVPQPGFPHYETVCKAYGIGMHFYNCRPEND 162 Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 W +++E+RR + K+L + NP NP G SRK +ED++ A E +L L +DE Sbjct: 163 WEADLDEIRRLKDDKT-----KLLIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDE 217 Query: 301 VYQDNVY---SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI 357 +Y V+ P+ F S ++ + V T+K + G+R G++ + Sbjct: 218 IYAGMVFKGKDPNATFTSVA--------DFETTVPRVILGGTAKN-LVVPGWRLGWLLYV 268 Query: 358 NLHPEIKGQL--VKLLSVRLC-PPVSGQAAM-DIVVNPPVAGEESFEQFSREKESVLGNL 413 + H L +K + + +C P QAA+ + ++N P + ++ + Sbjct: 269 DPHGNGPSFLEGLKRVGMLVCGPCTVVQAALGEALLNTPQEHL----------DQIVAKI 318 Query: 414 AKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEE 473 + A + + G+ +GAMY RI + + + D+ + KLLEE Sbjct: 319 EESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDL-------EKYRDIKTDVEFFEKLLEE 371 Query: 474 TGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA 523 + V+PG+ F R+T PVE + ++++K F +++A Sbjct: 372 ENVQVLPGTIFHA---PGFTRLTTTRPVEVYREAVERIK----AFCQRHA 414 >3H14-A nrPDB Length = 391 Score = 242 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 72/383 (18%), Positives = 128/383 (33%), Gaps = 50/383 (13%) Query: 135 ARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTI 194 A L Y+ + G+ +R+ +A GV DP + +T G+S G Sbjct: 49 AVEALAKSLETDALGYTVALGLPALRQRIARLY-GEWYGVDLDPGRVVITPGSSGGFLLA 107 Query: 195 LKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQE 254 L G + V I P YP Y ++ L + V+ EN V Sbjct: 108 FTALFDSGDR----VGIGAPGYPSYRQILRALGLVPVDLPTAPENRLQP--------VPA 155 Query: 255 AKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFH 314 D L + +P NPTG + + +I A + ++DE+Y Y Sbjct: 156 DFAGLDLAGLMVASPANPTGTMLDHAAMGALIEAAQAQGASFISDEIYHGIEYEAKA--- 212 Query: 315 SFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVR 374 E +S SK Y G+R G+M V + ++ ++ Sbjct: 213 ---------VTALELTDECYVINSFSK-YFSMTGWRVGWMVVPEDQVRVVERIA--QNMF 260 Query: 375 LCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNP 434 +C P + Q A ++ + + + + ++ +L L K P Sbjct: 261 ICAPHASQVAALAALDCDAELQANLDVYKANRKLMLERLPKAGF-----------TRIAP 309 Query: 435 LQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFR 494 GA Y + + + + ++LE+ G+ V PG F G R Sbjct: 310 PDGAFYVYADV-----------SDLTDDSRAFAAEILEKAGVAVTPGLDFDPERGAGTLR 358 Query: 495 MTILPPVEKLKTVLQKVKDFHIN 517 + ++ L +++ F Sbjct: 359 FSYARATADIEEGLDRLEAFMQA 381 >3QGU-A nrPDB Length = 449 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 77/371 (20%), Positives = 138/371 (37%), Gaps = 39/371 (10%) Query: 145 NSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGK 204 Y A QG +RE VA+ G D I+++ G+ I+ I + Sbjct: 102 EGYSGYGAEQGQGALREAVASTFYGHAGRA---ADEIFISDGSKCDIARIQMMF-----G 153 Query: 205 SRTGVMIPIPQYPLY--SAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK 262 S+ V + P YP+Y ++V+ + D N + + Sbjct: 154 SKPTVAVQDPSYPVYVDTSVMMGMTGDHNGTGFDGIEYMVCNPD--NHFFPDLSKAKRTD 211 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYE 322 ++ +P NPTG +R + ++++FA + L+ D Y + +PDC K +YE Sbjct: 212 IIFFCSPNNPTGAAATRAQLTELVNFARKNGSILVYDAAYALYISNPDC-----PKTIYE 266 Query: 323 MGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ 382 + +E SF Y G G R G+ V G+ V R+ Sbjct: 267 IPGADEVAIETCSFSK----YAGFTGVRLGWTVVPKALKYANGEPVHADWNRVMTTCFN- 321 Query: 383 AAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAF 442 A +IV +A + + +E +++ + A++ + F ++ G A Y + Sbjct: 322 GASNIVQAGGLACLQ--PEGLKEMNAMIKFYKENAQILKTTFTEM-GFSVYGGDDAPYIW 378 Query: 443 PRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVE 502 + P K P ++LE I PGSG+G G R + E Sbjct: 379 --VGFPGK-----------PSWDVFAEILERCNIVTTPGSGYGP-AGEGFVRASAFGSRE 424 Query: 503 KLKTVLQKVKD 513 + +++ K+ Sbjct: 425 NILEAVRRFKE 435 >2X5D-A nrPDB Length = 412 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 82/394 (20%), Positives = 161/394 (40%), Gaps = 51/394 (12%) Query: 123 DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPD-NI 181 D P+ P ++ + Q + YS S+G+ +R ++ + R V DP+ Sbjct: 48 DGPT-PPHIVEKLCTVAQREDTHG---YSTSRGIPRLRRAISHWYRDRY-DVQIDPESEA 102 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 +T G+ +G++ ++ + G +++P P YP++ A + L + Sbjct: 103 IVTIGSKEGLAHLMLATLDHGD----TILVPNPSYPIHIYGAVIAGAQVRSVPLVPGIDF 158 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 NEL RA++E+ P+++ + P NPT Q E V+ A + + ++ D Sbjct: 159 ---FNELERAIRESIPK--PRMMILGFPSNPTAQCVELDFFERVVALAKQYDVMVVHDLA 213 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y D VY + S +V VE F + SK Y G+R G+M +P Sbjct: 214 YADIVYDG-WKAPSIMQV----PGAKDIAVE---FFTLSKSY-NMAGWRIGFMV---GNP 261 Query: 362 EIKGQLVKLLSVRLCPPVS--GQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 E+ L ++ S + AA+ + + Q+ + ++ ++ L + + Sbjct: 262 ELVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIARQYQQRRDVLVKGLREAGWM 321 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 E+ + +MY + +I P + + + KLL++ + V Sbjct: 322 VEN------------PKASMYVWAKIPEPYAHLG---------SLEFAKKLLQDAKVSVS 360 Query: 480 PGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 PG GFG G H R ++ ++L+ ++ +K Sbjct: 361 PGIGFGD-YGDDHVRFALIENRDRLRQAVRGIKA 393 >1IAY-A nrPDB Length = 428 Score = 224 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 77/374 (20%), Positives = 154/374 (41%), Gaps = 28/374 (7%) Query: 145 NSLGSYSASQGVNCIREDVAAYITR-RDGGVPADPDNIYLTTGASDGISTILKILVSGGG 203 ++ ++ G+ R+ +A ++ + R G V DP+ + + GA+ TI+ L G Sbjct: 74 KAIANFQDYHGLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPGD 133 Query: 204 KSRTGVMIPIPQYPLYSAVISELDAIQ-VNYYLDEENCWALNVNELRRAVQEA-KDHCDP 261 ++P P YP ++ + +Q + + + N + + ++ A + A K + Sbjct: 134 ----AFLVPSPYYPAFNRDLRWRTGVQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKV 189 Query: 262 KVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY 321 K L + NP NP G + ++ V+ F + + L+ DE+Y V+ +F S ++L Sbjct: 190 KGLILTNPSNPLGTTLDKDTLKSVLSFTNQHNIHLVCDEIYAATVFDTP-QFVSIAEILD 248 Query: 322 EMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSG 381 E Y + + +S SK MG G+R G + + + ++ K+ S L + Sbjct: 249 EQEMTYCNKDLVHIVYSLSKD-MGLPGFRVG--IIYSFNDDVVNCARKMSSFGLVSTQTQ 305 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 + ++ E+ + F RE LG K T L +V GI C ++ Sbjct: 306 Y-----FLAAMLSDEKFVDNFLRESAMRLGKRHK--HFTNGL--EVVGIKCLKNNAGLFC 356 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPV 501 + + + +M ++ + + V PGS F +E FR+ Sbjct: 357 WMDLR------PLLRESTFDSEMSLWRVIINDVKLNVSPGSSFECQE-PGWFRVCFANMD 409 Query: 502 E-KLKTVLQKVKDF 514 + + L +++ F Sbjct: 410 DGTVDIALARIRRF 423 >3B46-A nrPDB Length = 447 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 74/405 (18%), Positives = 157/405 (38%), Gaps = 55/405 (13%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGA 187 P+ A K A++ L N YS ++G + + + +N+ +TTGA Sbjct: 72 PQFAIKEAQKALDIPMVNQ---YSPTRGRPSLINSLIKLYSPIYN-TELKAENVTVTTGA 127 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDE---------- 237 ++GI + L L++ G + V++ P + Y I V ++ Sbjct: 128 NEGILSCLMGLLNAGDE----VIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 183 Query: 238 ENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 297 W ++ + +A+ K + I P NP G+V +R+ + + + + + ++ Sbjct: 184 GEEWTIDFEQFEKAITSKT-----KAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 238 Query: 298 ADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI 357 +DEVY+ ++ F + E+G +L ++ G+R G+ V+ Sbjct: 239 SDEVYEHLYFTDS--FTRIATLSPEIG-------QLTLTVGSAGKSFAATGWRIGW--VL 287 Query: 358 NLHPEIKGQLVKLLSVRLC---PPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLA 414 +L+ E+ K R+C P +A + + + G FE+ +E Sbjct: 288 SLNAELLSYAAK-AHTRICFASPSPLQEACANSINDALKIG--YFEKMRQE-------YI 337 Query: 415 KKAKLTEDLFNQVPGIHCNPLQGAMYA---FPRIFIPAKAVEAAQAHQMAPDMFYCMKLL 471 K K+ +F+++ G+ +G + F ++ IP + D L+ Sbjct: 338 NKFKIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 396 Query: 472 EETGICVVPGSGF----GQREGTYHFRMTILPPVEKLKTVLQKVK 512 E G+ +P + F ++ R + L+ ++++K Sbjct: 397 NELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 441 >3ASB-A nrPDB Length = 400 Score = 215 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 73/365 (20%), Positives = 126/365 (34%), Gaps = 48/365 (13%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTG 208 Y G+ +R+ ++ R D I+++ GA + +L Sbjct: 70 GYGPDFGLPALRQKLSEDFYRGF----VDAKEIFISDGAKVDLFRLLSFF-----GPNQT 120 Query: 209 VMIPIPQYPLYSAVISELDAIQVN-YYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 V I P YP Y + A ++ +EN + E + +LC+ Sbjct: 121 VAIQDPSYPAYLDIARLTGAKEIIALPCLQENAF----------FPEFPEDTHIDILCLC 170 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 +P NPTG V ++ + ++H+A E ++ +L D Y + P S K ++E+ Sbjct: 171 SPNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDP-----SLPKSIFEIPDAR 225 Query: 328 SSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDI 387 +E+ SF +G G R G+ + G V R A++ Sbjct: 226 FCAIEINSFSKP----LGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPA 281 Query: 388 VVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFI 447 VAG Q + + + L F Sbjct: 282 -QEAGVAGLSILPQLEA-----IHYYRENSDLLRKALLATG----------FEVFGGEHA 325 Query: 448 PAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTV 507 P V+ QA+ D+F L E I + PG GFG R G+ R + L E + Sbjct: 326 PYLWVKPTQANISDRDLFDF--FLREYHIAITPGIGFG-RSGSGFVRFSSLGKREDILAA 382 Query: 508 LQKVK 512 ++++ Sbjct: 383 CERLQ 387 >2ZC0-A nrPDB Length = 407 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 85/455 (18%), Positives = 172/455 (37%), Gaps = 78/455 (17%) Query: 68 IVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSF 127 ++ KA E++ ++G+K I GD P L+ Sbjct: 22 VMKKASELQ---KKGVKL-----ISLAAGDPD-------------------PELIPRAVL 54 Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGA 187 E AK+ + ++ Y+ + G+ +RE++AA++ + D + P+NI +T G Sbjct: 55 GEIAKEVLEKEPKSV------MYTPANGIPELREELAAFLKKYD-HLEVSPENIVITIGG 107 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 + + + ++L+ G + I + P Y + + + + + V+ Sbjct: 108 TGALDLLGRVLIDPGD-------VVITENPSYINTLLAFEQLGAKIEGVPVDNDGMRVDL 160 Query: 248 LRRAVQEAKDHCD-PKVLCIINPG-NPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDN 305 L ++E K K++ I G NP G S + + ++ A + L ++ D Y Sbjct: 161 LEEKIKELKAKGQKVKLIYTIPTGQNPMGVTMSMERRKALLEIASKYDLLIIEDTAYNFM 220 Query: 306 VYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKG 365 Y ++ + V +A S G G+R G+ +I +K Sbjct: 221 RYEGG-------DIVPLKALDNEGRVIVAGTLSKVLG----TGFRIGW--IIAEGEILKK 267 Query: 366 QLVKLLSVRLCPP-VSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLF 424 L++ + C P +S A++ + FE++ E ++LG K+ + + L Sbjct: 268 VLMQKQPIDFCAPAISQYIALEYL------KRGYFEKYHLEG-ALLGYKEKRDIMLKALE 320 Query: 425 NQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGF 484 N +P M+ + + A + + +L+E G+ VVPG F Sbjct: 321 NHLPNAEFTKPIAGMFVMFFLP------------EGADGISFANELMEREGVVVVPGKPF 368 Query: 485 GQRE-GTYHFRMTILPPV-EKLKTVLQKVKDFHIN 517 E G R+ P E++ ++K+ + Sbjct: 369 YTDESGKNAIRLNFSRPSKEEIPIGIKKLAKLYKE 403 >2GB3-A nrPDB Length = 409 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 82/410 (20%), Positives = 145/410 (35%), Gaps = 66/410 (16%) Query: 119 PNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADP 178 P+L F E + ++ YS S G+ +RE A+Y RR V P Sbjct: 53 PDLKTPEVFFERIYENKPEVV---------YYSHSAGIWELREAFASYYKRRQR-VDVKP 102 Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE 238 +N+ +T G S+ I ++ + G + +++ P Y Y+A + E Sbjct: 103 ENVLVTNGGSEAILFSFAVIANPGDE----ILVLEPFYANYNAFAKIAGVKLIPVTRRME 158 Query: 239 NCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLA 298 +A+ N E+ + K + + NP NPTG V + + ++ A LFL+ Sbjct: 159 EGFAIPQNL------ESFINERTKGIVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIV 212 Query: 299 DEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVIN 358 DEVY + V+ + + ++ S SK + CG R G +I Sbjct: 213 DEVYSEIVFRGEFASALSIES-----------DKVVVIDSVSKKFSA-CGARVGC--LIT 258 Query: 359 LHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREK-ESVLGNLAKKA 417 + E+ +KL RL PP+ Q ++N + + + RE+ E+VL L + Sbjct: 259 RNEELISHAMKLAQGRLAPPLLEQIGSVGLLNLDDSFFDFVRETYRERVETVLKKLEEHG 318 Query: 418 KLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGI- 476 GA Y + + + +L + + Sbjct: 319 L-----------KRFTKPSGAFYITAELPV-------------EDAEEFARWMLTDFNMD 354 Query: 477 ----CVVPGSGFGQREGTYH--FRMTILPPVEKLKTVLQKVKDFHINFLE 520 V P GF G R+ + + L + + + F Sbjct: 355 GETTMVAPLRGFYLTPGLGKKEIRIACVLEKDLLSRAIDVLMEGLKMFCS 404 >1M4N-A nrPDB Length = 435 Score = 200 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 79/378 (20%), Positives = 154/378 (40%), Gaps = 30/378 (7%) Query: 147 LGSYSASQGVNCIREDVAAYITR-RDGGVPADPDNIYLTTGASDGISTILKILVSGGGKS 205 L + G+ ++ + ++ R V DP+++ LT GA+ T + L G Sbjct: 79 LALFQDYHGLPAFKKAMVDFMAEIRGNKVTFDPNHLVLTAGATSANETFIFCLADPG--- 135 Query: 206 RTGVMIPIPQYPLYSAVISELDAIQ-VNYYLDEENCWALNVNELRRAVQEA-KDHCDPKV 263 V+IP P YP + + ++ V + N + + L A QEA K + K Sbjct: 136 -EAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSSNGFQITETALEEAYQEAEKRNLRVKG 194 Query: 264 LCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEM 323 + + NP NP G +R + ++ F ++ + L++DE+Y +S F S +VL + Sbjct: 195 VLVTNPSNPLGTTMTRNELYLLLSFVEDKGIHLISDEIYSGTAFSSPS-FISVMEVLKDR 253 Query: 324 GPEYSSNV--ELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSG 381 + +S V + +S SK +G G+R G + + + K+ S L + Sbjct: 254 NCDENSEVWQRVHVVYSLSKD-LGLPGFRVG--AIYSNDDMVVAAATKMSSFGLVSSQTQ 310 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 +++ ++ ++ + + E L ++ KL L Q GI C ++ Sbjct: 311 H-----LLSAMLSDKKLTKNYIAENHKRLKQ--RQKKLVSGL--QKSGISCLNGNAGLFC 361 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILP-P 500 + + +++ +M K++ E + + PGS E FR+ P Sbjct: 362 WVDMR------HLLRSNTFEAEMELWKKIVYEVHLNISPGSSCHCTE-PGWFRVCFANLP 414 Query: 501 VEKLKTVLQKVKDFHINF 518 L +Q++K F + Sbjct: 415 ERTLDLAMQRLKAFVGEY 432 >3OP7-A nrPDB Length = 375 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 95/398 (23%), Positives = 158/398 (39%), Gaps = 70/398 (17%) Query: 124 SPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYL 183 S + PED K+ LQ N Y +G ++ V+ T P+ I Sbjct: 41 SGTNPEDFYKK----LQGTKLN----YGWIEGSPAFKKSVSQLYTG------VKPEQILQ 86 Query: 184 TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWAL 243 T GA+ +L L+ G V+ P Y + L A + ++EEN W Sbjct: 87 TNGATGANLLVLYSLIEPGDH----VISLYPTYQQLYDIPKSLGAEVDLWQIEEENGWLP 142 Query: 244 NVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 ++ +LR+ ++ K++CI N NPTG V R +E+++ A E ++L+DEVY+ Sbjct: 143 DLEKLRQLIRPTT-----KMICINNANNPTGAVMDRTYLEELVEIASEVGAYILSDEVYR 197 Query: 304 DNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEI 363 + S +V Y+ G + +S SK Y G R G++ + +I Sbjct: 198 SF---SELDVPSIIEV-YDKG---------IAVNSLSKTY-SLPGIRIGWVAANHQVTDI 243 Query: 364 KGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDL 423 L R + D+V +A + E R + + NLA + E+ Sbjct: 244 ------LRDYRDYTMICAGVFDDLVAQLALAHYQ--EILERNRHILEENLAILDQWIEEE 295 Query: 424 FNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDM---FYCMKLLEETGICVVP 480 P + AV + ++A DM +C++LL+E G+ +VP Sbjct: 296 -------------------PLVSYIRPAVVSTSFVKIAVDMPMEDFCLQLLQEHGVLLVP 336 Query: 481 GSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINF 518 G+ F E + R+ E L L+K+ F F Sbjct: 337 GNRF---ERDGYVRLGFACEQETLIKGLEKLSQFLRRF 371 >1V2E-A nrPDB Length = 381 Score = 190 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 78/395 (19%), Positives = 145/395 (36%), Gaps = 67/395 (16%) Query: 124 SPSFPED--AKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 PS P + RR L Y+ G+ +RE +A +P+++ Sbjct: 34 FPSNPPPPFLLEAVRRALGRQD-----QYAPPAGLPALREALAEEF-------AVEPESV 81 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLY--SAVISELDAIQVNYYLDEEN 239 +T+GA++ + +L+ LV G + V++ P + +Y A ++ A V L E Sbjct: 82 VVTSGATEALYVLLQSLVGPGDE----VVVLEPFFDVYLPDAFLAGAKARLVRLDLTPE- 136 Query: 240 CWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 + L+++ L +A+ + L + P NPTG V + +E + A LFL++D Sbjct: 137 GFRLDLSALEKALTP-----RTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISD 191 Query: 300 EVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 EVY + Y + L E PE + V ++ + GYR G+ ++ Sbjct: 192 EVYDELYYGER------PRRLREFAPERTFTV------GSAGKRLEATGYRVGW--IVGP 237 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 + P QA + + +A E F + RE ++ L Sbjct: 238 KEFMPRLAGMRQWTSFSAPTPLQAGVAEAL--KLARREGFYEALRE------GYRRRRDL 289 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 + G+ +G + + +L+EE + ++ Sbjct: 290 LAGGLRAM-GLRVYVPEGTYFLMAELPGWD-----------------AFRLVEEARVALI 331 Query: 480 PGSGFG-QREGTYHFRMTILPPVEKLKTVLQKVKD 513 P S F + FR E+L L+++ Sbjct: 332 PASAFYLEDPPKDLFRFAFCKTEEELHLALERLGR 366 >3ELE-A nrPDB Length = 398 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 70/397 (17%), Positives = 143/397 (36%), Gaps = 56/397 (14%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGA 187 P+ + ++ +L Y+++QG R +A ++ G + DN+Y+T GA Sbjct: 50 PQIVNDTIKELVTDYDSVALHGYTSAQGDVETRAAIAEFLNNTHG-THFNADNLYMTMGA 108 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 + +S + L S + P +P Y ++ A V D E+ + ++ + Sbjct: 109 AASLSICFRALTSDAYDEFITIA---PYFPEYKVFVNAAGARLVEVPADTEH-FQIDFDA 164 Query: 248 LRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE------KLFLLADEV 301 L + + + + I +P NP+G V S + I+ + ++ +F++ADE Sbjct: 165 LEERI-----NAHTRGVIINSPNNPSGTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEP 219 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y++ VY + +Y N + +S S + G R GY+ V + Sbjct: 220 YREIVYDG---------IKVPFVTKYYDNTLVCYSYSKS---LSLPGERIGYVLVPDEVY 267 Query: 362 EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTE 421 + + A+ V P + + + + + + L Sbjct: 268 D--------KAELYAAVCGAGRALGYVCAPSLFQKMIVKCQGATGD--INAYKENRDLLY 317 Query: 422 DLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG 481 + ++ G HC GA Y F + +C K +E + +V Sbjct: 318 EGLTRI-GYHCFKPDGAFYMFVKALE-------------DDSNAFCEK-AKEEDVLIVAA 362 Query: 482 SGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINF 518 GFG R++ E +K + + + + Sbjct: 363 DGFG---CPGWVRISYCVDREMIKHSMPAFEKIYKKY 396 >4WP0-A nrPDB Length = 472 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 76/450 (16%), Positives = 151/450 (33%), Gaps = 64/450 (14%) Query: 101 MGQQPITFLRQVMALCTYPNLLD-SPSFPED--AKKRARRILQACGGNSLGSYSASQGVN 157 + P ++ + NL P FP A + + + L Y+ + G Sbjct: 13 IDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFM--LNQYTKTFGYP 70 Query: 158 CIREDVAAYITRRDGGVPADP-DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQY 216 + + +A++ G DP N+ +T G + T + LV G + V+I P + Sbjct: 71 PLTKILASFFGELLGQ-EIDPLRNVLVTVGGYGALFTAFQALVDEGDE----VIIIEPFF 125 Query: 217 PLYSAVISELDAIQVNYYLDE----------ENCWALNVNELRRAVQEAKDHCDPKVLCI 266 Y + V L + W L+ EL K L + Sbjct: 126 DCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFT-----SRTKALVL 180 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 P NP G+V SR+ +E V + + + DEVYQ VY + + Sbjct: 181 NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHI-----SIASLPGM 235 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLC-PPVSGQAAM 385 + + + ++ G++ G++ I L + + P QAA+ Sbjct: 236 WERTLTI----GSAGKTFSATGWKVGWVLGP---DHIMKHLRTVHQNSVFHCPTQSQAAV 288 Query: 386 D--------IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQG 437 + P + + R ++ ++ +L Q G+ QG Sbjct: 289 AESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSL------------QSVGLKPIIPQG 336 Query: 438 AMYAFPRIFIPAKAVEAAQAHQMAP-DMFYCMKLLEETGICVVPGSGF----GQREGTYH 492 + + I + + P D + +++ G+ +P S F Q+ ++ Sbjct: 337 SYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHY 396 Query: 493 FRMTILPPVEKLKTVLQKVKDFHINFLEKY 522 R + L+ + +K++ + + Y Sbjct: 397 IRFCFVKDEATLQAMDEKLRKWKVELENLY 426 >3FVS-A nrPDB Length = 422 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 75/446 (16%), Positives = 150/446 (33%), Gaps = 64/446 (14%) Query: 101 MGQQPITFLRQVMALCTYPNLLD-SPSFPED--AKKRARRILQACGGNSLGSYSASQGVN 157 + P ++ + NL P FP A + + + L Y+ + G Sbjct: 13 IDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFM--LNQYTKTFGYP 70 Query: 158 CIREDVAAYITRRDGGVPADP-DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQY 216 + + +A++ G DP N+ +T G + T + LV G + V+I P + Sbjct: 71 PLTKILASFFGELLGQ-EIDPLRNVLVTVGGYGALFTAFQALVDEGDE----VIIIEPFF 125 Query: 217 PLYSAVISELDAIQVNYYLDE----------ENCWALNVNELRRAVQEAKDHCDPKVLCI 266 Y + V L + W L+ EL K L + Sbjct: 126 DCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFT-----SRTKALVL 180 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 P NP G+V SR+ +E V + + + DEVYQ VY + + Sbjct: 181 NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHI-----SIASLPGM 235 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLC-PPVSGQAAM 385 + + + ++ G++ G++ I L + + P QAA+ Sbjct: 236 WERTLTI----GSAGKTFSATGWKVGWVLGP---DHIMKHLRTVHQNSVFHCPTQSQAAV 288 Query: 386 D--------IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQG 437 + P + + R ++ ++ +L Q G+ QG Sbjct: 289 AESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSL------------QSVGLKPIIPQG 336 Query: 438 AMYAFPRIFIPAKAVEAAQAHQMAP-DMFYCMKLLEETGICVVPGSGF----GQREGTYH 492 + + I + + P D + +++ G+ +P S F Q+ ++ Sbjct: 337 SYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHY 396 Query: 493 FRMTILPPVEKLKTVLQKVKDFHINF 518 R + L+ + +K++ + + Sbjct: 397 IRFCFVKDEATLQAMDEKLRKWKVEL 422 >4FL0-A nrPDB Length = 456 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 74/431 (17%), Positives = 143/431 (33%), Gaps = 67/431 (15%) Query: 105 PITFLRQVMALCTYPNL----LDSPSFPEDAKKRARRILQACGG-----NSLGSYSASQG 155 P R++ + +PN+ L + E ++ + Y QG Sbjct: 54 PEINRRELEHIEKHPNVQLISLGTGDTTEPIPEQITSHMSNFAHGLSTVEGYRGYGLEQG 113 Query: 156 VNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQ 215 +R+ +A R + + ++++ GA IS + +L S + + P Sbjct: 114 NKTLRKAIAETFYR---DLHVKSNEVFVSDGAQSDISRLQLLL-----GSNVTIAVQDPT 165 Query: 216 YPLYSAVISELDAIQ------------VNYYLDEENCWALNVNELRRAVQEAKDHCDPKV 263 +P Y + V N + ++ V Sbjct: 166 FPAYIDSSVIIGQTGHFHEKTKKYQNVVYMPCGPNNSFFPDLAM----------TPRTDV 215 Query: 264 LCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEM 323 + +P NPTG V SRK + ++ FA ++ D Y + + +YE+ Sbjct: 216 IFFCSPNNPTGYVASRKQLHQLVDFAKTNGSIIIFDSAYAAFIEDGS------PRSIYEI 269 Query: 324 GPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQA 383 +E++SF + G G R G+ + + G + R+ Sbjct: 270 PGAREVAIEVSSFSK----FAGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFN-G 324 Query: 384 AMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFP 443 A +I +A S +E SV + K+ D + G+ A Y + Sbjct: 325 ASNIAQAGGLACLSS--GGLKEIRSVNNYYKENRKILMDTLVSL-GLKVYGGVNAPYLWV 381 Query: 444 RIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEK 503 + + ++LE T I VPGSGFG G + R++ + Sbjct: 382 H-------------FKGSKSWDVFNEILENTHIITVPGSGFGP-GGEEYLRISGFGRRDH 427 Query: 504 LKTVLQKVKDF 514 + +++++F Sbjct: 428 IVEASKRLQNF 438 >1YIY-A nrPDB Length = 429 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 66/404 (16%), Positives = 133/404 (32%), Gaps = 37/404 (9%) Query: 124 SPSFPEDAKKRARRILQACGGNSLGS-YSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 P + A + L + Y+ G + + ++ ++ + Sbjct: 46 FPDYHAPKYALNALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVL 105 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDE----- 237 +T GA + + ++ V G + V+I P + Y ++ I L Sbjct: 106 VTVGAYEALYATIQGHVDEGDE----VIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKTGG 161 Query: 238 ---ENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKL 294 W L+ NEL E K++ I P NP G+V R +E V + + + Sbjct: 162 TISSADWVLDNNELEALFNEKT-----KMIIINTPHNPLGKVMDRAELEVVANLCKKWNV 216 Query: 295 FLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYM 354 ++DEVY+ V+ P + + + + + ++ G++ G+ Sbjct: 217 LCVSDEVYEHMVFEPFEHIR-----ICTLPGMWERTITI----GSAGKTFSLTGWKIGWA 267 Query: 355 EVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLA 414 + Q+V V C + A+ + + +S E + S+ G L Sbjct: 268 YGPEALLK-NLQMVHQNCVYTCATPIQE-AIAVGFETELKRLKSPECYF---NSISGELM 322 Query: 415 KKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 474 K +V G++ QG + V+ Q D + + + Sbjct: 323 AKRDYMASFLAEV-GMNPTVPQGGYFMVADWSSLDSKVDLTQETDARKDYRFTKWMTKSV 381 Query: 475 GICVVPGSGFGQRE----GTYHFRMTILPPVEKLKTVLQKVKDF 514 G+ +P S F G R E L+ + ++ + Sbjct: 382 GLQGIPPSAFYSEPNKHLGEDFVRYCFFKKDENLQKAAEILRKW 425 >2ZJG-A nrPDB Length = 410 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 66/401 (16%), Positives = 130/401 (32%), Gaps = 43/401 (10%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADP-DNIYLTTG 186 P K+ + N Y+ G + + ++ + DP + I + G Sbjct: 38 PSYVKEELSKAAFIDNMNQ---YTRGFGHPALVKALSCLYGK-IYQRQIDPNEEILVAVG 93 Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDE--------- 237 A + ++ LV G + V+I +P Y Y ++ A+ V L Sbjct: 94 AYGSLFNSIQGLVDPGDE----VIIMVPFYDCYEPMVRMAGAVPVFIPLRSKPTDGMKWT 149 Query: 238 ENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 297 + W + EL K + + P NP G+V +R+ ++ + + + Sbjct: 150 SSDWTFDPRELESKFSSKT-----KAIILNTPHNPLGKVYTRQELQVIADLCVKHDTLCI 204 Query: 298 ADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI 357 +DEVY+ VY+ + + + + + S T + G+ G +I Sbjct: 205 SDEVYEWLVYTGHTHVK-----IATLPGMWERTITIGSAGKTFSVTGWKLGWSIGPAHLI 259 Query: 358 NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKA 417 Q V+ S C QAA+ + + E + S+ L K Sbjct: 260 KHL-----QTVQQNSFYTCATPL-QAALAEAFWIDIKRMDDPECYF---NSLPKELEVKR 310 Query: 418 KLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGIC 477 L N V G+ G + + + + + D + + + + Sbjct: 311 DRMVRLLNSV-GLKPIVPDGGYFIIADVSSLGADLSDMNSDE-PYDYKFVKWMTKHKKLT 368 Query: 478 VVPGSGFGQREGTYHF----RMTILPPVEKLKTVLQKVKDF 514 +P S F + HF R + L + + + Sbjct: 369 AIPVSAFCDSKSKPHFEKLVRFCFIKKDSTLDAAEEIFRAW 409 >1U08-A nrPDB Length = 386 Score = 172 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 72/423 (17%), Positives = 143/423 (33%), Gaps = 57/423 (13%) Query: 100 AMGQQPITFLRQVMALCTYPNLLD----SPSF--PEDAKKRARRILQACGGNSLGSYSAS 153 + Q T Q+ AL ++ P F P ++R L Y+ Sbjct: 11 KLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQER----LAHHVAQGANQYAPM 66 Query: 154 QGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPI 213 GV +RE +A R G P +I +T GA++ + + LV G + V+ Sbjct: 67 TGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDE----VICFD 122 Query: 214 PQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPT 273 P Y Y+ I+ I L + + ++ E + E +++ + P NP+ Sbjct: 123 PSYDSYAPAIALSGGIVKRMALQPPH-FRVDWQEFAALLSE-----RTRLVILNTPHNPS 176 Query: 274 GQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVEL 333 V + + ++F+++DEVY+ +S + V + Sbjct: 177 ATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQGH-----ASVLAHPQLRERAVAV 231 Query: 334 ASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCP-PVSGQAAMDIVVNPP 392 +SF T G++ GY I ++ K+ Q A+ ++ Sbjct: 232 SSFGKT----YHMTGWKVGYCVAPAP---ISAEIRKVHQYLTFSVNTPAQLALADMLRAE 284 Query: 393 VAGEESFEQFSRE-KESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKA 451 + F R+ ++ ++ L + + P +G + Sbjct: 285 PEHYLALPDFYRQKRDILVNALNESR------------LEILPCEGTYFL---------- 322 Query: 452 VEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTY-HFRMTILPPVEKLKTVLQK 510 + A D+ +C L +E G+ +P S F + R+ L ++ Sbjct: 323 LVDYSAVSTLDDVEFCQWLTQEHGVAAIPLSVFCADPFPHKLIRLCFAKKESTLLAAAER 382 Query: 511 VKD 513 ++ Sbjct: 383 LRQ 385 >3EI8-A nrPDB Length = 432 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 74/422 (17%), Positives = 135/422 (31%), Gaps = 47/422 (11%) Query: 105 PITFLRQVMALCTYPNL----LDSPSFPEDAKKR-----ARRILQACGGNSLGSYSASQG 155 P R+ L YP+ L E + A++ + Y A QG Sbjct: 40 PEIARRRSAHLLKYPDAQVISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYSGYGAEQG 99 Query: 156 VNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQ 215 +R +A GG+ D+++++ GA IS + + S + + P Sbjct: 100 AKPLRAAIAKTF---YGGLGIGDDDVFVSDGAKCDISRLQVMF-----GSNVTIAVQDPS 151 Query: 216 YPLY--SAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPT 273 YP Y S+VI N + + ++ +P NPT Sbjct: 152 YPAYVDSSVIMGQTGQFNTDVQKYGNIEYMRCTPENGFFPDLSTVGRTDIIFFCSPNNPT 211 Query: 274 GQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVEL 333 G +R+ + ++ FA + ++ D Y + + + ++E+ +E Sbjct: 212 GAAATREQLTQLVEFAKKNGSIIVYDSAYAMYMSDDN------PRSIFEIPGAEEVAMET 265 Query: 334 ASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPV 393 ASF Y G G R G+ + G V R+ A +I + Sbjct: 266 ASFS----NYAGFTGVRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFN-GASNISQAGAL 320 Query: 394 AGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVE 453 A + V+G + + D F + G + A Y + Sbjct: 321 ACLT--PEGLEAMHKVIGFYKENTNIIIDTFTSL-GYDVYGGKNAPYVWVHFPN------ 371 Query: 454 AAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 ++LE+T + PGSG G R++ E + ++ K Sbjct: 372 -------QSSWDVFAEILEKTHVVTTPGSG-FGPGGEGFVRVSAFGHRENILEACRRFKQ 423 Query: 514 FH 515 + Sbjct: 424 LY 425 >2O0R-A nrPDB Length = 411 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 73/402 (18%), Positives = 132/402 (32%), Gaps = 58/402 (14%) Query: 122 LDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPD-N 180 P + A+ + + Y G + A RR GV DP+ Sbjct: 34 FPDEDGPPKMLQAAQDAIAG----GVNQYPPGPGSAPL-RRAIAAQRRRHFGVDYDPETE 88 Query: 181 IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE-N 239 + +T GA++ I+ + LV G + V++ P Y YS V++ A +V L + Sbjct: 89 VLVTVGATEAIAAAVLGLVEPGSE----VLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGR 144 Query: 240 CWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 +AL+ + LRRAV + L I +P NPTG V S + + A L ++ D Sbjct: 145 GFALDADALRRAVTP-----RTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITD 199 Query: 300 EVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 EVY+ V+ + E S++ G++ G+ Sbjct: 200 EVYEHLVFDHARHLP---------LAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAE 250 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 + LS P Q A+ + ++ A + +L + Sbjct: 251 LIAGVRAAKQYLSYVGGAPF--QPAVALALDTEDAWVAALRN----------SLRARRDR 298 Query: 420 TEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 ++ G + G + + +C L E+ G+ + Sbjct: 299 LAAGLTEI-GFAVHDSYGTYFL----------CADPRPLGYDDSTEFCAALPEKVGVAAI 347 Query: 480 PGSGFGQRE----------GTYHFRMTILPPVEKLKTVLQKV 511 P S F + R T + L ++++ Sbjct: 348 PMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRL 389 >3AV7-A nrPDB Length = 448 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 74/475 (15%), Positives = 166/475 (34%), Gaps = 69/475 (14%) Query: 65 RGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPI-----TFLRQVMALCTYP 119 RG + + ++ + + E I++ +GD + + + +R+++ L Sbjct: 17 RGSHMHEDVQLNIYVHSQEGIGMEENIKSMLGDVERFFSKKALEMRASEVRELLKLVETS 76 Query: 120 NLL-------DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDG 172 +++ + +FP++ + + + Y ++G +RE + ++ +R G Sbjct: 77 DIISLAGGLPNPKTFPKEIIRDILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYG 136 Query: 173 GVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVN 232 + +I +T+G+ + I ++ ++ G V++ P Y + + + Sbjct: 137 ISQDN--DIMITSGSQQALDLIGRVFLNPGD----IVVVEAPTYLAALQAFNFYEPQYIQ 190 Query: 233 YYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPG--NPTGQVQSRKCIEDVIHFAW 290 LD+E + V L ++E K + P NP G + + ++ A Sbjct: 191 IPLDDE---GMKVEILEEKLKELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLELAS 247 Query: 291 EEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYR 350 E ++ D+ Y + YS + + V S G+R Sbjct: 248 EYDFIVVEDDPYGELRYSGNPEKK-------IKALDNEGRVIYLGTFSKILA----PGFR 296 Query: 351 GGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQ---FSREKE 407 G+M + I+ + S LC V GQ V+ + E + ++ Sbjct: 297 IGWM--VGDPGIIRKMEIAKQSTDLCTNVFGQVVAWRYVDGGYLEKHIPEIRKFYKPRRD 354 Query: 408 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 467 ++L L + G+ +G M+ + + PD Sbjct: 355 AMLEALEEFMP---------EGVKWTKPEGGMFIWVTL----------------PDGIDS 389 Query: 468 MKLLEET---GICVVPGSGFGQ-REGTYHFRMTIL-PPVEKLKTVLQKVKDFHIN 517 K+LE G+ VPG F R+ R+ +K+ ++++ + Sbjct: 390 KKMLERAIKKGVAYVPGEAFYAHRDVKNTMRLNFTYVDEDKIMEGIKRLAETIKE 444 >1X0M-A nrPDB Length = 403 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 66/402 (16%), Positives = 138/402 (34%), Gaps = 57/402 (14%) Query: 126 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTT 185 +FP++ + + + Y ++G +RE + ++ +R G + +I +T+ Sbjct: 45 TFPKEIIRDILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGISQDN--DIMITS 102 Query: 186 GASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNV 245 G+ + I ++ ++ G V++ P Y + + + LD+E + V Sbjct: 103 GSQQALDLIGRVFLNPGD----IVVVEAPTYLAALQAFNFYEPQYIQIPLDDE---GMKV 155 Query: 246 NELRRAVQEAKDHCDPKVLCIINPG--NPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 L ++E K + P NP G + + ++ A E ++ D+ Y Sbjct: 156 EILEEKLKELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYG 215 Query: 304 DNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEI 363 + YS + + V S G+R G+M + I Sbjct: 216 ELRYSGNPEKK-------IKALDNEGRVIYLGTFSKILA----PGFRIGWM--VGDPGII 262 Query: 364 KGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQ---FSREKESVLGNLAKKAKLT 420 + + S LC V GQ V+ + E + ++++L L + Sbjct: 263 RKMEIAKQSTDLCTNVFGQVVAWRYVDGGYLEKHIPEIRKFYKPRRDAMLEALEEFMP-- 320 Query: 421 EDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET---GIC 477 G+ +G M+ + + PD K+LE G+ Sbjct: 321 -------EGVKWTKPEGGMFIWVTL----------------PDGIDSKKMLERAIKKGVA 357 Query: 478 VVPGSGFGQ-REGTYHFRMTIL-PPVEKLKTVLQKVKDFHIN 517 VPG F R+ R+ +K+ ++++ + Sbjct: 358 YVPGEAFYAHRDVKNTMRLNFTYVDEDKIMEGIKRLAETIKE 399 >3B1C-A nrPDB Length = 392 Score = 145 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 64/394 (16%), Positives = 140/394 (35%), Gaps = 52/394 (13%) Query: 122 LDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 +D PE ++ + + Y+ + + + + V + + + D ++I Sbjct: 41 MDFEVMPE-----VKQAIHDYAEQLVYGYTYAS--DELLQAVLDW-EKSEHQYSFDKEDI 92 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC- 240 G IS ++ G V+I P YP ++ + + V+ L EEN Sbjct: 93 VFVEGVVPAISIAIQAFTKEG----EAVLINSPVYPPFARSVRLNNRKLVSNSLKEENGL 148 Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 + ++ +L + E D K+ + NP NP G+V R+ +E + H + + L++DE Sbjct: 149 FQIDFEQLENDIVEN----DVKLYLLCNPHNPGGRVWEREVLEQIGHLCQKHHVILVSDE 204 Query: 301 VYQDNVYSPDCR--FHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVIN 358 ++QD F++ + SS + + T Y Sbjct: 205 IHQDLTLFGHEHVSFNTVSPDFKDFALVLSSATKTFNIAGTKNSYA-------------- 250 Query: 359 LHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAK 418 I + V+ + + +A E ++ ++ L + + Sbjct: 251 ----IIENPTLCAQFKHQQLVNNHHEVSSL--GYIATETAYRYGKPWLVALKAVLEENIQ 304 Query: 419 LTEDLF-NQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGIC 477 + F + P + QG + + + D + + L ++ + Sbjct: 305 FAVEYFAQEAPRLKVMKPQGTYLIWLDF----------SDYGLTDDALFTL-LHDQAKVI 353 Query: 478 VVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKV 511 + GS +G EG H R+ I P ++ + +++ Sbjct: 354 LNRGSDYGS-EGELHARLNIAAPKSLVEEICKRI 386 >3JTX-A nrPDB Length = 396 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 64/424 (15%), Positives = 142/424 (33%), Gaps = 53/424 (12%) Query: 98 AQAMGQ--QPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQG 155 + + + + + P + P P K L A + L Y + G Sbjct: 11 PYPFARLHEAMQGISAPEGMEAVPLHIGEPKHPTP--KVITDALTAS-LHELEKYPLTAG 67 Query: 156 VNCIREDVAAYITRRDGGVPADPDN-IYLTTGASDGISTILKILVSG-GGKSRTGVMIPI 213 + +R+ A ++ RR G+ D DN I G+ + + + ++ +++ + ++ P Sbjct: 68 LPELRQACANWLKRRYDGLTVDADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIVSPN 127 Query: 214 PQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPT 273 P Y +Y + L ++++ + + + V + K++ + +P NP+ Sbjct: 128 PFYQIYEG-ATLLGGGEIHFANCPAPSFNPDWRSISEEVWK-----RTKLVFVCSPNNPS 181 Query: 274 GQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVEL 333 G V ++V + + +DE Y + + + + S +L Sbjct: 182 GSVLDLDGWKEVFDLQDKYGFIIASDECYSEIYFDGNKPLGCLQAAAQL----GRSRQKL 237 Query: 334 ASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPV 393 F S SK G R G+ + G L + L G A V + Sbjct: 238 LMFTSLSKR-SNVPGLRSGF---------VAGDAELLKNFLLYRTYHGSAMSIPVQRASI 287 Query: 394 AGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVE 453 A + + + + + + +F+ + Y + ++ Sbjct: 288 AAWDDEQHVIDNRRLYQEKFERVIPILQQVFD------VKLPDASFYIWLKVPD------ 335 Query: 454 AAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQR------EGTYHFRMTILPPVEKLKTV 507 D+ + L ++ I V+PG F R G + R+ ++ V Sbjct: 336 -------GDDLAFARNLWQKAAIQVLPG-RFLARDTEQGNPGEGYVRIALVADVATCVKA 387 Query: 508 LQKV 511 + + Sbjct: 388 AEDI 391 >1WST-A nrPDB Length = 417 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 71/405 (17%), Positives = 147/405 (36%), Gaps = 52/405 (12%) Query: 125 PSFP-EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYL 183 +FP E KK A +L+ +L Y ++G +R +A ++ +R +P I Sbjct: 54 ETFPVETIKKIAVEVLEEHADKAL-QYGTTKGFTPLRLALARWMEKRY-DIPMSKVEIMT 111 Query: 184 TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWAL 243 G+ + I ++ ++ G +++ P Y D ++ LD + + Sbjct: 112 VAGSQQALDLIGRVFLNPGDP----IVVEAPTYLAAIQAFKYYDPEFISIPLD-DKGMRV 166 Query: 244 NVNELRRAVQEAKDHCDPKVLCIINP-GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 ++ E + + K K++ ++ NP G S + ++ A E ++ D Y Sbjct: 167 DLLE-EKLEELRKQGKRVKIVYTVSTFQNPAGVTMSVDRRKKLLELANEYDFLIVEDGPY 225 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 + YS + + V S G+R G+ + HP Sbjct: 226 SELRYSGE-------PTPPIKHFDDYGRVIYLGTFSKILA----PGFRIGW---VAAHPH 271 Query: 363 IKGQL-VKLLSVRLCPPVSGQA-AMDIVVNPPVAGE--ESFEQFSREKESVLGNLAKKAK 418 + ++ + S+ LC GQA A V N + + E + ++++L L + Sbjct: 272 LIRKMEIAKQSIDLCTNTFGQAIAWKYVENGYLDEHIPKIIEFYKPRRDAMLEALEEYMP 331 Query: 419 LTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICV 478 G+ +G M+ R+ +P D M+ G+ Sbjct: 332 ---------EGVEWTKPEGGMFV--RVTLPE-----------GIDTKLMMERAVAKGVAY 369 Query: 479 VPGSGFGQ-REGTYHFRMTIL-PPVEKLKTVLQKVKDFHINFLEK 521 VPG F R+ R+ P E ++ ++++ + +++ Sbjct: 370 VPGEAFFVHRDKKNTMRLNFTYVPEETIREGVRRLAETIKEEMKR 414 >1VP4-A nrPDB Length = 425 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 72/422 (17%), Positives = 153/422 (36%), Gaps = 49/422 (11%) Query: 106 ITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAA 165 + F A+ + D +FP + + + YS ++G +++ + Sbjct: 37 LKFAADKDAISFGGGVPDPETFPRKELAEIAKEIIEKEYHYTLQYSTTEGDPVLKQQILK 96 Query: 166 YITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISE 225 + R G D DN+ T G+ + I K+ + + P Y I+ Sbjct: 97 LLERMYGITGLDEDNLIFTVGSQQALDLIGKLFLDDES-------YCVLDDPAYLGAINA 149 Query: 226 LDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK----VLCIINPGNPTGQVQSRKC 281 N+ + +++N L R + E + K + + N NP G S + Sbjct: 150 FRQYLANFVVVPLEDDGMDLNVLERKLSEFDKNGKIKQVKFIYVVSNFHNPAGVTTSLEK 209 Query: 282 IEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSK 341 + ++ A + LF++ D+ Y Y + + + GPE + ++ SK Sbjct: 210 RKALVEIAEKYDLFIVEDDPYGALRYEGE----TVDPIFKIGGPER-----VVLLNTFSK 260 Query: 342 GYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPP-VSGQAAMDIVVNPPV--AGEES 398 G R G V I+ + S LC P ++ + A + + + + Sbjct: 261 VLA--PGLRIG--MVAGSKEFIRKIVQAKQSADLCSPAITHRLAARYLERYDLLEQLKPT 316 Query: 399 FEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAH 458 E + R++ +L L + F+ +PG+ +G ++ + + E + Sbjct: 317 IELYRRKRTVMLNALEE-------YFSDIPGVKWVKSEGGLFIWLTLPEGFDTWEMFEYA 369 Query: 459 QMAPDMFYCMKLLEETGICVVPGSGFGQ-REGTYHFRMTI-LPPVEKLKTVLQKVKDFHI 516 + + VPG F E + R++ LPP EK+ ++++++ + Sbjct: 370 -------------KRKKVFYVPGRVFKVYDEPSPSMRLSFCLPPDEKIVEGIKRLREVVL 416 Query: 517 NF 518 + Sbjct: 417 EY 418 >2O1B-A nrPDB Length = 404 Score = 141 bits (355), Expect = 6e-34, Method: Composition-based stats. Identities = 59/391 (15%), Positives = 135/391 (34%), Gaps = 50/391 (12%) Query: 123 DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 D P+ P+ ++ L Y A G ++ + + R+ D + Sbjct: 58 DGPT-PQGIIDHFQKALTIPENQ---KYGAFHGKEAFKQAIVDFYQRQYNVTLDKEDEVC 113 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 + G +G+ + +++ G V++P P Y Y A + D V L+ + Sbjct: 114 ILYGTKNGLVAVPTCVINPGDY----VLLPDPGYTDYLAGVLLADGKPVPLNLEPPHYL- 168 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 + +++ + + K++ + P NPTG +++ ++ I ++ D Y Sbjct: 169 PDWSKVDSQIIDKT-----KLIYLTYPNNPTGSTATKEVFDEAIAKFKGTDTKIVHDFAY 223 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 + + +E+ +S SKGY G+R G+ + + Sbjct: 224 GAFGFDAK------NPSILASENGKDVAIEI---YSLSKGY-NMSGFRVGF----AVGNK 269 Query: 363 IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 Q +K + G + + + ++ F E+ +V + + Sbjct: 270 DMIQALKKYQTHTNAGMFG-----ALQDAAIYALNHYDDFLEEQSNVFKTRRDRFEAMLA 324 Query: 423 LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGS 482 + + +G +Y + + + L++E I V PG Sbjct: 325 KAD----LPFVHAKGGIYVW------------LETPPGYDSEQFEQFLVQEKSILVAPGK 368 Query: 483 GFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 FG+ G + R+++ +KL ++ + Sbjct: 369 PFGEN-GNRYVRISLALDDQKLDEAAIRLTE 398 >5Z0Q-C nrPDB Length = 389 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 121/377 (32%), Gaps = 48/377 (12%) Query: 138 ILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKI 197 LQ + Y + + E + R G P+ + G GI+ ++ Sbjct: 54 ALQQRVQQGVFGYGVTS--EALAEVAIERMESRFGW-KIQPEWLVFLPGVVTGINIAVRA 110 Query: 198 LVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD-EENCWALNVNELRRAVQEAK 256 ++ + P YP + ++ L E+ W L+++ E + Sbjct: 111 F----TEAHQSTVSATPIYPPFFLAPKLAGRQHLSAALRLEQQRWVLDLDS-----HEDR 161 Query: 257 DHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSF 316 + K+L + NP NP G V RK +E + FA L + +DE++ D V P + F Sbjct: 162 MSGNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHDLLVCSDEIHCDLVLEPGVQHIPF 221 Query: 317 KKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLC 376 + + S SK G G + +PE++ + ++ + Sbjct: 222 A------SLSDDAAQRSITLMSPSKS-FNIAG--LGASLAVIPNPELRARFNRMRKGMV- 271 Query: 377 PPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQ 436 P A G+ ++ L L + N++PG+ + Sbjct: 272 -PDVDVLAYVAASAAWREGQPWL-------DAQLDYLRANRDMLAQHVNRLPGLSMVTPE 323 Query: 437 GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMT 496 + + A A E+ G+ G FG R Sbjct: 324 ASFLGWIDASGLGVADPAL--------------FFEKHGLGFSSGRDFGNDR---FVRFN 366 Query: 497 ILPPVEKLKTVLQKVKD 513 P + L+ LQ++ Sbjct: 367 FGCPRQLLEEALQRMTR 383 >3L8A-A nrPDB Length = 421 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 59/347 (17%), Positives = 114/347 (32%), Gaps = 41/347 (11%) Query: 167 ITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISEL 226 R++ ++I G IS L+ G V+I P Y ++ I Sbjct: 108 WERKEHDYAVVKEDILFIDGVVPAISIALQAFSEKGD----AVLINSPVYYPFARTIRLN 163 Query: 227 DAIQVNYYLDEENC-WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDV 285 D V L N + ++ +L + + + + K+ + +P NP G+V + + Sbjct: 164 DHRLVENSLQIINGRFEIDFEQLEKDIIDN----NVKIYLLCSPHNPGGRVWDNDDLIKI 219 Query: 286 IHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMG 345 + + L++DE++QD + + +S + S++ Sbjct: 220 AELCKKHGVILVSDEIHQDLALFGNTHH--------SLNTLDASYKDFTIILSSATKTFN 271 Query: 346 ECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSR- 404 G + + + N K Q +L + + P G A E + Sbjct: 272 IAGTKNSFAIIQNESLRRKFQYRQLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEG 331 Query: 405 EKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDM 464 + V+ L K K I +G + A A Sbjct: 332 NIKLVIKELEAKTK-----------IKVMEPEGTYLVWLDFSAYAIAQP----------- 369 Query: 465 FYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKV 511 KL E + + G+ FG +EG Y R+ + P ++ L ++ Sbjct: 370 QLSEKLQNEAKVVLNDGAHFG-KEGKYFARLNVATPKNTVQEALSRI 415 >2ZY2-A nrPDB Length = 544 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 79/403 (19%), Positives = 139/403 (34%), Gaps = 63/403 (15%) Query: 161 EDVAAYITRRDGGVPADPDNI--YLTTGASDGISTILKIL-VSGGGKSRTGVMIPIPQYP 217 + V YI R G P+++ + G + ++ I + L +SG K+ V I +P + Sbjct: 145 QIVRQYIVREMAGGAVPPESVDLFAVEGGTAAMAYIFESLRISGLLKAGDKVAIGMPVFT 204 Query: 218 LYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQ 275 Y + +++ D +V + D +N W + EL + D K+ +NP NP Sbjct: 205 PYIEIPELAQYDLKEVPIHADPDNGWQYSDAELDKLKDP-----DVKIFFCVNPSNPPSV 259 Query: 276 VQSRKCIEDVIHFA--WEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVEL 333 ++ ++ V L +L D+VY F + L+ + P + V Sbjct: 260 KMDQRSLDRVRAIVAEQRPDLLILTDDVY--------GTFADEFQSLFSVCPRNTLLV-- 309 Query: 334 ASFHSTSKGYMGECGYRGG---------YMEVINLHPEIKGQLVKLLSVRLCPPV----- 379 +S SK Y G G+R G + ++ PE + + L P V Sbjct: 310 ---YSFSK-YFGATGWRLGVIAAHKDNVFDHALSQLPESAKKALDHRYRSLLPDVRSLKF 365 Query: 380 ------------SGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQV 427 A S E ++ L + + E + Sbjct: 366 IDRLVADSRVVALNHTAGLSTPQQVQMVLFSLFALMDEADAYKQALKQLIRRREATLYRE 425 Query: 428 PGIHC--NPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLL----EETGICVVPG 481 G+ NP Y + + Q A +L +ETGI ++PG Sbjct: 426 LGMPPLENPNSVNYYTLIDLQNVTCRLYGEAFSQWAVQQSSTGDMLFRVADETGIVLLPG 485 Query: 482 SGFGQREGTYHFRMTILPPVE--KLKTVLQKVKDFHINFLEKY 522 GFG + + L E + L+++ D E+Y Sbjct: 486 RGFGSDRPSGRASLANLNEYEYAAIGRALRRLAD---ELYEQY 525 >1IJI-A nrPDB Length = 356 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 118/311 (37%), Gaps = 36/311 (11%) Query: 161 EDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYS 220 + V + G P+ + ++ GA +GI +++ G + ++ P Y +YS Sbjct: 61 KAVIENYAQYAG---VKPEQVLVSRGADEGIELLIRAFCEPG---KDAILYCPPTYGMYS 114 Query: 221 AVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRK 280 V +E ++ +N W L++ + + KV+ + +P NPTGQ+ + + Sbjct: 115 -VSAETIGVECRTVPTLDN-WQLDLQGISDKLD------GVKVVYVCSPNNPTGQLINPQ 166 Query: 281 CIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTS 340 ++ K ++ADE Y + C S L E LA + S Sbjct: 167 DFRTLLELT-RGKAIVVADEAYIEF-----CPQASLAGWLAEYP-------HLAILRTLS 213 Query: 341 KGYMGECGYRGGYMEVINLHPEIKGQLVK-LLSVRLCPPVSGQAAMDIVVNPPVAGEESF 399 K G R G+ + E+ L+K + L PV+ AA + VA E Sbjct: 214 KA-FALAGLRCGFTL---ANEEVINLLMKVIAPYPLSTPVADIAAQALSPQGIVAMRERV 269 Query: 400 EQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQ 459 Q E+E ++ L + E +F+ + + F ++ + + Sbjct: 270 AQIIAEREYLIAALKE-IPCVEQVFDSETNYILARFKASSAVFKSLWDQGIIL---RDQN 325 Query: 460 MAPDMFYCMKL 470 P + C+++ Sbjct: 326 KQPSLSGCLRI 336 >4DQ6-A nrPDB Length = 391 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 47/355 (13%), Positives = 119/355 (33%), Gaps = 44/355 (12%) Query: 161 EDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYS 220 E + ++ RR + + + G IS L++ K+ +MI P Y ++ Sbjct: 74 ESIVNWLYRRHNW-KIKSEWLIYSPGVIPAISL----LINELTKANDKIMIQEPVYSPFN 128 Query: 221 AVISELDAIQVNYYLD--EENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQS 278 +V+ + + L E + ++ ++ ++ D K+ + NP NP G+V + Sbjct: 129 SVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK------DVKLFILCNPHNPVGRVWT 182 Query: 279 RKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHS 338 + ++ + + + +++DE++ D + + + + Sbjct: 183 KDELKKLGDICLKHNVKIISDEIHSDIILKKHKH-------IPMASISKEFEKNTITCMA 235 Query: 339 TSKGYMGECGYRGGYMEVINLHPE-IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEE 397 +K G + Y+ + + + + ++ S A N E Sbjct: 236 PTKT-FNIAGLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLES 294 Query: 398 SFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQA 457 E + + + + +P + +G + Sbjct: 295 FLEYLESNIDFAIKYINEN----------MPKLKVRKPEGTYLLWVDFSALGL------- 337 Query: 458 HQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVK 512 D L+++ + + G+ FG G+ + R+ + P L+ L ++K Sbjct: 338 ----SDEELESILVQKGKVALNQGNSFGI-GGSGYQRINLACPRSMLEEALIRIK 387 >2ZY3-A nrPDB Length = 546 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 81/410 (19%), Positives = 142/410 (34%), Gaps = 67/410 (16%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPD---NIYLTTGASDGISTILKIL-VSGGGK 204 +Y + I E + R+ G A P N++ G + ++ I + L ++G K Sbjct: 133 NYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLK 192 Query: 205 SRTGVMIPIPQYPLYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK 262 + V I +P + Y + +++ +V D W +EL + A K Sbjct: 193 AGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELDKLKDPA-----IK 247 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEE--KLFLLADEVYQDNVYSPDCRFHSFKKVL 320 + +NP NP ++ +E V + E L +L D+VY F + L Sbjct: 248 IFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVY--------GTFADDFQSL 299 Query: 321 YEMGPEYSSNVELASFHSTSKGYMGECGYRGG---------YMEVINLHPEIKGQLVKLL 371 + + PE + V +S SK Y G G+R G + ++ E + + Sbjct: 300 FAICPENTLLV-----YSFSK-YFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHR 353 Query: 372 SVRLCPPVSG-------QAAMDIVVNPPVAGEESFEQFS-------------REKESVLG 411 L P V A V AG + +Q E + L Sbjct: 354 YRSLLPDVRSLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLK 413 Query: 412 NLAKKAKLTEDLFNQVPGIHCNPLQGA--MYAFPRIFIPAKAVEAAQAHQMAPDMFYCMK 469 L ++ E + G+ + A Y + + + A Sbjct: 414 QLIRRR---ETTLYRELGMPPLRDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGD 470 Query: 470 LL----EETGICVVPGSGFGQREGTYHFRMTILPPVE--KLKTVLQKVKD 513 +L +ETGI ++PG GFG + + L E + L+K+ D Sbjct: 471 MLFRIADETGIVLLPGRGFGSNRPSGRASLANLNEYEYAAIGRALRKMAD 520 >3NRA-A nrPDB Length = 407 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 62/383 (16%), Positives = 114/383 (29%), Gaps = 45/383 (11%) Query: 140 QACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILV 199 + +Y+ +G IR+ +A + G D + +T G + + V Sbjct: 64 AGVQSGGVQAYTEYRGDLGIRDLLAPRLAAFTGAPVDARDGLIITPGTQGALFLAVAATV 123 Query: 200 SGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD----EENCWALNVNELRRAVQEA 255 + G K V I P Y ++ + V LD +E L++ L A Sbjct: 124 ARGDK----VAIVQPDYFANRKLVEFFEGEMVPVQLDYVSADETRAGLDLTGLEEAF--- 176 Query: 256 KDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHS 315 +V NP NP G V S + I + A ++AD++Y Y+ S Sbjct: 177 --KAGARVFLFSNPNNPAGVVYSAEEIGQIAALAARYGATVIADQLYSRLRYAG----AS 230 Query: 316 FKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL 375 + + E + + V + T G G +I +++ Sbjct: 231 YTHLRAEAAVDAENVVTIMGPSKTESLSGYRLGVAFGSRAIIARMEKLQA---------- 280 Query: 376 CPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPL 435 ++ F++ E + + G+ Sbjct: 281 ------IVSLRAAGYSQAVLRGWFDEAPGWMEDRIARHQAIRDELLHVLRGCEGVFARTP 334 Query: 436 QGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRM 495 Q Y FPR+ A A + L + G+ V PG+ F R+ Sbjct: 335 QAGSYLFPRLPKLAVAP-----------AEFVKILRLQAGVVVTPGTEFSPHT-ADSVRL 382 Query: 496 TILPPVEKLKTVLQKVKDFHINF 518 E +++ + Sbjct: 383 NFSQDHEAAVAAARRIVTLVERY 405 >3T32-A nrPDB Length = 383 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 60/389 (15%), Positives = 137/389 (35%), Gaps = 48/389 (12%) Query: 126 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTT 185 P+ + ++ ++ + + Y+ D+ T++ + I + Sbjct: 37 EVPQPIQTALKKRIE----HPIFGYTLP---PENIGDIICNWTKKQYNWDIQKEWIVFSA 89 Query: 186 GASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC-WALN 244 G +ST ++ K V++ P YP + +++ + L ++N +A++ Sbjct: 90 GIVPALSTSIQAF----TKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQNDTYAID 145 Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 L + Q+ K++ + +P NP G+V ++ + + + + ++ADE++ D Sbjct: 146 FEHLEKQFQQ-----GVKLMLLCSPHNPIGRVWKKEELTKLGSLCTKYNVIVVADEIHSD 200 Query: 305 NVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIK 364 +Y D F + E+ + + + + + +I + E Sbjct: 201 IIY-ADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQAS----------IIIIPNEKL 249 Query: 365 GQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLF 424 Q + R A + + + + E E + Sbjct: 250 RQAFTSIQYRQGFHGLNIFAYTAMQSAYTECNDWLNEIRFYIEDNAKF------ACEYIK 303 Query: 425 NQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETG-ICVVPGSG 483 + +P + +G+ + A ++ D KLLEE G I V PG Sbjct: 304 DHIPTLSVMKPEGSFLLWIDC----------SALNLSQDER--TKLLEEKGKIIVEPGEK 351 Query: 484 FGQREGTYHFRMTILPPVEKLKTVLQKVK 512 +G G H + I P L+ +L +++ Sbjct: 352 YGL-GGEEHIGINIGCPRSVLEEILNRLR 379 >4M2J-A nrPDB Length = 406 Score = 125 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 74/403 (18%), Positives = 125/403 (31%), Gaps = 48/403 (11%) Query: 117 TYPNLLDSPSFPEDAKKR--ARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGV 174 ++ S P + RI A + S SQG +R +A Sbjct: 45 DIHDISSSGVHPYSFAEIRDVCRIPAADLDAVVMDDSVSQGGEGVRRAIADRYAG----- 99 Query: 175 PADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYY 234 D D + +T G+S+ I+ L L+ G + V++ Y Sbjct: 100 -GDADRVLVTHGSSEAIALTLNALLHRGDR----VVVQEGIYHSLGHYPRAAGCDVAVLP 154 Query: 235 LDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKL 294 ++ + L V + + P NPTG S + + + Sbjct: 155 GRAVRDGEIDPDVLAGLVTPGTA-----AVIVNFPHNPTGVTLSPQGLRALKERTAATGA 209 Query: 295 FLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYM 354 L+ D + + +VL + G + V S+ + SK G G R G+ Sbjct: 210 VLVWDAATAEIAHR--------WEVLADPGADGGDTV---SYGTLSKT-FGLPGLRVGWA 257 Query: 355 EVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLA 414 L ++ L P V A + + G + E Sbjct: 258 VAPKELLTATFPLRDRTTLFLSPLVELVAERAVRHADELIGARAAE-----------ARH 306 Query: 415 KKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 474 A LT + + P +G + A P +A Q + +C++LLE Sbjct: 307 NLAHLTGWMAAHEELVRWTPPEGGVCALPVFRELERAAAGPQEVE-----RFCLELLERH 361 Query: 475 GICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHIN 517 +VPG+ FG G R+ P E + L + F Sbjct: 362 RTLLVPGTAFGAPHGA---RLGFGGPQEDFRAGLDGLSRFLRE 401 >2ZYJ-A nrPDB Length = 397 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 75/425 (17%), Positives = 144/425 (33%), Gaps = 64/425 (15%) Query: 102 GQQPITFLRQVMALCTYPNLLDS-------PSFPEDAKKRARRILQACGGNSLGSYSASQ 154 G+ + +R+++ L P +L FP++ A + G YS ++ Sbjct: 15 GRIQASTIRELLKLTQRPGILSFAGGLPAPELFPKEEAAEAAARILREKGEVALQYSPTE 74 Query: 155 GVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIP 214 G +R VA +I R P+ + +TTG+ + + K+ + G V++ P Sbjct: 75 GYAPLRAFVAEWIGVR-------PEEVLITTGSQQALDLVGKVFLDEGSP----VLLEAP 123 Query: 215 QYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPG--NP 272 Y + EE +++ L ++ P+ L +I P NP Sbjct: 124 SYMGAIQAFRLQGPRFLTVPAGEE---GPDLDALEEVLK----RERPRFLYLI-PSFQNP 175 Query: 273 TGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVE 332 TG + + ++ E L ++ D+ Y++ Y + R S ++ E G Sbjct: 176 TGGLTPLPARKRLLQMVMERGLVVVEDDAYREL-YFGEARLPSLFELAREAGYPG----- 229 Query: 333 LASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPP 392 + S SK G R + HPE +LV+ ++N Sbjct: 230 VIYLGSFSKVLS--PGLRVAFAV---AHPEALQKLVQAKQGADLHTP--------MLNQM 276 Query: 393 VAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQV--PGIHCNPLQGAMYAFPRIFIPAK 450 + E E FS E V +KA+ ++ + +G M+ + + Sbjct: 277 LVHELLKEGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVWMELP---- 332 Query: 451 AVEAAQAHQMAPDMFYCMKLLEETGICVVPGSG-FGQREGTYHFRMTILP-PVEKLKTVL 508 + E + VPG F G R++ E + + Sbjct: 333 ---------KGLSAEGLFRRALEENVAFVPGGPFFANGGGENTLRLSYATLDREGIAEGV 383 Query: 509 QKVKD 513 +++ Sbjct: 384 RRLGR 388 >3FDD-A nrPDB Length = 533 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 76/407 (18%), Positives = 132/407 (32%), Gaps = 61/407 (14%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPD---NIYLTTGASDGISTILKIL-VSGGGK 204 +Y + I E + R+ G A P N++ G + ++ I + + V+G K Sbjct: 133 NYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESMKVNGLLK 192 Query: 205 SRTGVMIPIPQYPLYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK 262 + V I +P + Y + +++ +V D W +EL + A K Sbjct: 193 AGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPALNWQYPDSELDKLKDPA-----IK 247 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEE--KLFLLADEVYQDNVYSPDCRFHSFKKVL 320 + +NP NP + +E V E L +L D+VY F + L Sbjct: 248 IFFCVNPSNPPSVKMDERSLERVRKIVAEHRPDLMILTDDVY--------GTFADGFQSL 299 Query: 321 YEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLH---------PEIKGQLVKLL 371 + + P + V +S SK Y G G+R G + + PE + + Sbjct: 300 FAICPANTLLV-----YSFSK-YFGATGWRLGVVAAHKENIFDLALGRLPESEKTALDDR 353 Query: 372 SVRLCPPV-----------------SGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLA 414 L P V A S E + L Sbjct: 354 YRSLLPDVRSLKFLDRLVADSRAVALNHTAGLSTPQQVQMTLFSLFALMDESDQYKHTLK 413 Query: 415 KKAKLTEDLFNQVPGIHCNPLQGA--MYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLL- 471 + + E + G + A Y + + + A +L Sbjct: 414 QLIRRREATLYRELGTPPQRDENAVDYYTLIDLQDVTSKLYGEAFSKWAVKQSSTGDMLF 473 Query: 472 ---EETGICVVPGSGFGQREGTYHFRMTILPPVE--KLKTVLQKVKD 513 +ETGI ++PG GFG + + L E + L+++ D Sbjct: 474 RIADETGIVLLPGRGFGSDRPSGRASLANLNEYEYAAIGRALRQMAD 520 >3FDB-A nrPDB Length = 377 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 53/380 (13%), Positives = 128/380 (33%), Gaps = 48/380 (12%) Query: 134 RARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGIST 193 + + Y + + + A + R G A P+ I+ G+ Sbjct: 40 AVLQAITDAVQREAFGYQPDGSL--LSQATAEFYADRYG-YQARPEWIFPIPDVVRGLYI 96 Query: 194 ILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQ 253 + +++ V++P P YP + ++S + +N++++ + Q Sbjct: 97 A----IDHFTPAQSKVIVPTPAYPPFFHLLSATQREGIFIDATG----GINLHDVEKGFQ 148 Query: 254 EAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRF 313 + + + NP NP G V + + + ++ A +L DE++ V+ Sbjct: 149 A-----GARSILLCNPYNPLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVFDGQ--- 200 Query: 314 HSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSV 373 H+ + + + + SK + G ++I +P Sbjct: 201 HTVAAGVSDTAASVCITIT-----APSKAW-NIAG--LKCAQIIFSNPSDAEH-----WQ 247 Query: 374 RLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCN 433 +L P + A+ ++ A + ++E + N L ++ ++PG Sbjct: 248 QLSPVIKDGASTLGLIAAEAAYRYGTDFLNQEVAYLKNN---HDFLLHEIPKRIPGAKIT 304 Query: 434 PLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHF 493 P+Q + ++ +E+ + + G+ FG+ +GT Sbjct: 305 PMQATYLMWIDFRDTTIEGSPSEF------------FIEKAKVAMNDGAWFGE-DGTGFC 351 Query: 494 RMTILPPVEKLKTVLQKVKD 513 R+ E L+ + ++ Sbjct: 352 RLNFATSREVLEEAIDRMAK 371 >3F6T-A nrPDB Length = 533 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 85/485 (17%), Positives = 165/485 (34%), Gaps = 79/485 (16%) Query: 92 RANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRIL---------QAC 142 + I + G +R+ + P+ D F DA L + Sbjct: 66 KLTINNGIMAGYINTDGIRERLFAFLDPDKNDEDKFLIDAVNYCHTELGLNRDKVVAEWV 125 Query: 143 GGNSLGSYS-ASQGVNCIREDVAAYITRRDGGVPADPD--NIYLTTGASDGISTILKILV 199 G +Y + + + + ++ + +++ T G + I L Sbjct: 126 NGAVANNYPVPDRCLVNTEKIINYFLQELSYKDANLAEQTDLFPTEGGTAAIVYAFHSLA 185 Query: 200 -SGGGKSRTGVMIPIPQYPLYSAV--ISELDAIQVNYYLDEENCWALNVNELRRAVQEAK 256 + K + I P + Y + + + + ++V+ + E+N W + NE+ + + Sbjct: 186 ENHLLKKGDKIAINEPIFTPYLRIPELKDYELVEVDLHSYEKNDWEIEPNEIEKLKDPS- 244 Query: 257 DHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEK-LFLLADEVYQDNVYSPDCRFHS 315 K L ++NP NPT + + + + L +++DEVY V + Sbjct: 245 ----IKALIVVNPTNPTSKEFDTNALNAIKQAVEKNPKLMIISDEVYGAFVPN------- 293 Query: 316 FKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLH----------PEIKG 365 K +Y + P + V +S SK G G+R G + + + Sbjct: 294 -FKSIYSVVPYNTMLV-----YSYSK-LFGCTGWRLGVIALNEKNVFDDNIAHLDKVELR 346 Query: 366 QLVKLLSV------------RLCPPVSGQAAM--DIVVNPPVAGEESFEQFSREKESVLG 411 QL K S RLC + P E F + G Sbjct: 347 QLHKRYSSVVLDPDKMKFIDRLCADSRSIGLYHTAGLSTPQQIMEALFSMTHLLTSTNGG 406 Query: 412 ----NLAKKAKLTEDLFNQVPGIHCNPLQGA-----MYAFPRIFIPAKAVEAAQAHQMAP 462 + KL + ++Q+ P Y+ I+ A+ + + Sbjct: 407 SDDPYIDIARKLVSERYDQLHDAMQAPKDETDTNTHYYSLIDIYRLAEKIYGKEFRDYLT 466 Query: 463 D----MFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILP-PVEKL----KTVLQKVKD 513 + + + +KL E+ G+ +V G GFG + G R++ P E K VL+ +K+ Sbjct: 467 NNFEQVDFLLKLAEKNGVVLVDGVGFGAKPGE--LRVSQANLPTEDYALIGKQVLELLKE 524 Query: 514 FHINF 518 ++ F Sbjct: 525 YYEEF 529 >3EZS-A nrPDB Length = 376 Score = 113 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 72/415 (17%), Positives = 139/415 (33%), Gaps = 58/415 (13%) Query: 104 QPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDV 163 + IT ++ + L ++P F +DA K +SL Y S +R Sbjct: 17 KEITPKKRGLDLGIGEPQFETPKFIQDALK--------NHTHSLNIYPKSAFEESLRAAQ 68 Query: 164 AAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVI 223 + RR + + + T G+ + + ++ + P P Y +Y Sbjct: 69 RGFFKRRF-KIELKENELISTLGSREVLFNFPSFVL--FDYQNPTIAYPNPFYQIYEGAA 125 Query: 224 SELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIE 283 + A + L +EN + ++NE K+ + ++ + +P NPTG+ S + + Sbjct: 126 KFIKAKSLLMPLTKENDFTPSLNE--------KELQEVDLVILNSPNNPTGRTLSLEELI 177 Query: 284 DVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGY 343 + A + L+ DE Y + + S + G E NV + HS SK Sbjct: 178 SWVKLALKHDFILINDECYSEIYENTPP--PSLLEACMLAGNEAFKNVLV--IHSLSKRS 233 Query: 344 MGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFS 403 G R G+ I G L + G + + + A Sbjct: 234 SA-PGLRSGF---------IAGDSRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAE 283 Query: 404 REKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPD 463 + NL K+ ++ I+ + Y + + Sbjct: 284 FFRNIYANNLKLARKIFKNTL-----IYPY----SFYVYLPV---------------QNG 319 Query: 464 MFYCMKLLEETGICVVPGSGFG-QREGTYHFRMTILPPVEKLKTVLQKVKDFHIN 517 + L + GI +P G R G + R+ ++ L+ L+ ++ + N Sbjct: 320 ENFAKTLYQNEGIITLPALYLGRNRIGADYVRLALVYDTPLLEKPLEIIETYREN 374 >2DOU-A nrPDB Length = 376 Score = 113 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 69/355 (19%), Positives = 122/355 (34%), Gaps = 53/355 (14%) Query: 161 EDVAAYITRRDGGVPADPD-NIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLY 219 E+ A + R G V DP G+ +G++ +L L +++P YP Y Sbjct: 70 EEAARWYEGRYG-VGLDPRREALALIGSQEGLAHLLLALTEPED----LLLLPEVAYPSY 124 Query: 220 SAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSR 279 L E+ + +L+ + KVL + P NPTG V Sbjct: 125 FGAARVASLRTFLIPLREDG-----LADLKA--VPEGVWREAKVLLLNYPNNPTGAVADW 177 Query: 280 KCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHST 339 E+ + A + L+L+ D Y D VY + E + S Sbjct: 178 GYFEEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKE---------RVVELFSL 228 Query: 340 SKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESF 399 SK Y G+R G+ E +L ++ V Sbjct: 229 SKSY-NLAGFRLGFAL---GSEEALARLERVKGVID------------FNQYAGVLRMGV 272 Query: 400 EQFSREKESVLGNLAKKAKLTEDLFNQVPG-IHCNPLQGAMYAFPRIFIPAKAVEAAQAH 458 E KE V G + + + G + P + MY + R+ Sbjct: 273 EALKTPKEVVRGYARVYRERALGMAEALKGVLSLLPPRATMYLWGRLP------------ 320 Query: 459 QMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 + D+ + ++L+E G+ + PG G G R+ ++ P+E+L +++++ Sbjct: 321 EGVDDLEFGLRLVER-GVALAPGRG-FGPGGKGFVRIALVRPLEELLEAAKRIRE 373 >3CQ5-A nrPDB Length = 369 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 104/276 (37%), Gaps = 35/276 (12%) Query: 147 LGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSR 206 L Y + +R+++AAYIT++ GV DN++ G+++ + +L+ GG R Sbjct: 63 LNRY-PERDAVELRDELAAYITKQ-TGVAVTRDNLWAANGSNEILQQLLQAF---GGPGR 117 Query: 207 TGVMIPIPQYPLYSAVISEL--DAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVL 264 T + P Y ++ + + I V+ D + + E+R P ++ Sbjct: 118 TALGFQ-PSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAK--------QPDIV 168 Query: 265 CIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMG 324 + P NPTG V S +E +I+ A ++ DE Y + SP L E Sbjct: 169 FVTTPNNPTGDVTSLDDVERIINVA---PGIVIVDEAYAEFSPSPSAT------TLLEKY 219 Query: 325 PEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAA 384 P L + SK G R GY I ++ L L QAA Sbjct: 220 PTK-----LVVSRTMSKA-FDFAGGRLGYFVAN--PAFIDAVMLVRLPYHLSA--LSQAA 269 Query: 385 MDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLT 420 + + + E+ S E+ V L + Sbjct: 270 AIVALRHSADTLGTVEKLSVERVRVAARLEELGYAV 305 >1C7O-A nrPDB Length = 399 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 59/398 (14%), Positives = 138/398 (34%), Gaps = 47/398 (11%) Query: 127 FPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTG 186 P + + ++ L + Y+ ++ V ++ R D I T G Sbjct: 45 NPPELIEGLKKYLDET----VLGYTGPT--EEYKKTVKKWMKDRH-QWDIQTDWIINTAG 97 Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW-ALNV 245 + ++ G GV+I P Y + I + + L E++ + ++ Sbjct: 98 VVPAVFNAVREFTKPGD----GVIIITPVYYPFFMAIKNQERKIIECELLEKDGYYTIDF 153 Query: 246 NELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDN 305 +L + ++ + K L +P NP G+V + ++ + + L L +DE++ D Sbjct: 154 QKLEKLSKDK----NNKALLFCSPHNPVGRVWKKDELQKIKDIVLKSDLMLWSDEIHFDL 209 Query: 306 VYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKG 365 + H+ + + E + + +F + SK G G +I +P+I+ Sbjct: 210 IM--PGYEHTVFQSIDEQLADKT-----ITFTAPSKT-FNIAG--MGMSNIIIKNPDIRE 259 Query: 366 QLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFN 425 + K P + A E +++ + + + + K ++ +D F Sbjct: 260 RFTKSRDATSGMPFT--------TLGYKACEICYKECGKWLDGCIKVIDKNQRIVKDFFE 311 Query: 426 -QVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGF 484 P I ++G + +A + + + + G F Sbjct: 312 VNHPEIKAPLIEGTYLQWIDFRALKMDHKAMEEFMIHKAQIFFDE-----------GYIF 360 Query: 485 GQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKY 522 G G R+ + P ++ L+++ + ++ Sbjct: 361 GD-GGIGFERINLAAPSSVIQESLERLNKALKDLKNRH 397 >3LY1-A nrPDB Length = 354 Score = 106 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 65/339 (19%), Positives = 125/339 (36%), Gaps = 61/339 (17%) Query: 168 TRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP--LYSAVISE 225 + + +I LT G+S+GI ++ S + ++IP Y + A I+ Sbjct: 58 NKLAAHHQVEAPSILLTAGSSEGIRAAIEAYASLEAQ----LVIPELTYGDGEHFAKIAG 113 Query: 226 LDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDV 285 + +V + WA ++ L+ AV + P ++ ++NP NPTG + IE Sbjct: 114 MKVTKVKML----DNWAFDIEGLKAAVA---AYSGPSIVYLVNPNNPTGTITPADVIEPW 166 Query: 286 IHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMG 345 I +F++ DE Y + V P RF S ++ + + N+ L S G Sbjct: 167 IASKPANTMFIV-DEAYAEFVNDP--RFRSISPMITQ----GAENIILLKTFSKIHAMAG 219 Query: 346 E-CGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSR 404 GY + VI L G+ V + + A+M+ + +F +S+ Sbjct: 220 MRVGYAVAHPTVIALM----GRYVAGEKINFSGVDAALASMN---------DSAFITYSK 266 Query: 405 EKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDM 464 + V ++ + + P +G F ++ +P K + Sbjct: 267 KSNDV------SRQILLKALEDLK-LPYLPSEGNF-VFHQLVVPLKDYQTH--------- 309 Query: 465 FYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEK 503 + + G+ + G F R+++ P E Sbjct: 310 ------MADAGVLI--GRAF--PPADNWCRISLGTPQEM 338 >3DZZ-A nrPDB Length = 391 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 59/364 (16%), Positives = 132/364 (36%), Gaps = 49/364 (13%) Query: 161 EDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYS 220 + VA + P + D +G IS +++ S G + +++ P Y ++ Sbjct: 69 KAVADWEEIEHRARPKE-DWCVFASGVVPAISAMVRQFTSPGDQ----ILVQEPVYNMFY 123 Query: 221 AVISELDAIQVNYYLDEENC-WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSR 279 +VI ++ L EN +++N +L + +++ NP NP G S Sbjct: 124 SVIEGNGRRVISSDLIYENSKYSVNWADLEEKL----ATPSVRMMVFCNPHNPIGYAWSE 179 Query: 280 KCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHST 339 + ++ + + ++ L++DE++ D V + + + ++ + + S S Sbjct: 180 EEVKRIAELCAKHQVLLISDEIHGDLVLTDE-------DITPAFTVDWDAKNWVVSLISP 232 Query: 340 SKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESF 399 SK + I +P+++ + + + + P + + Sbjct: 233 SKTFNLA---ALHAACAIIPNPDLRARAEESF------------FLAGIGEPNLLAIPAA 277 Query: 400 EQFSREKESVLGNLAK--KAKLTED---LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEA 454 E L L + + L +VP + + A+ I E Sbjct: 278 IAAYEEGHDWLRELKQVLRDNFAYAREFLAKEVPEVKVLDSNASYLAWVDISALGMNAE- 336 Query: 455 AQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDF 514 +C L E+TG+ + G+G+ + G R+ + P E + +Q++K Sbjct: 337 ----------DFCKYLREKTGLIISAGNGY-RGNGHEFVRINLACPKELVIDGMQRLKQG 385 Query: 515 HINF 518 +N Sbjct: 386 VLNL 389 >1D2F-A nrPDB Length = 390 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 54/376 (14%), Positives = 127/376 (33%), Gaps = 42/376 (11%) Query: 137 RILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILK 196 L + + YS + + +A + + + D + + ++ Sbjct: 48 EALNQRLMHGVFGYSRWKN-DEFLAAIAHWFSTQHY-TAIDSQTVVYG----PSVIYMVS 101 Query: 197 ILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE-NCWALNVNELRRAVQEA 255 L+ ++ GV+I P Y + I + L+++ + W ++ +L + Sbjct: 102 ELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVALEKQADGWFCDMGKLEAVL--- 158 Query: 256 KDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHS 315 + K++ + +P NPTG+V + +E + + +++DE++ D V+ + Sbjct: 159 -AKPECKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVW-GEQPHIP 216 Query: 316 FKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL 375 + V + L + S S G G +E + + +K Sbjct: 217 WSNVAR-------GDWALLTSGSKSFNIPALTG-AYGIIE-NSSSRDAYLSALKGRDGLS 267 Query: 376 CPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPL 435 P V A ++ + ++ + + + A P ++ Sbjct: 268 SPSVLALTAHIAAYQQGAPWLDALRIYLKDNLTYIADKMNAA---------FPELNWQIP 318 Query: 436 QGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRM 495 Q A+ + D L+E+ + ++PG +G+ EG R+ Sbjct: 319 QSTYLAWLDLRPLNI-----------DDNALQKALIEQEKVAIMPGYTYGE-EGRGFVRL 366 Query: 496 TILPPVEKLKTVLQKV 511 P KL+ + + Sbjct: 367 NAGCPRSKLEKGVAGL 382 >3IF2-A nrPDB Length = 444 Score = 99.6 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 75/448 (16%), Positives = 143/448 (31%), Gaps = 82/448 (18%) Query: 96 GDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQG 155 G+ + FL AL + + + S+ +YS QG Sbjct: 40 GNPAKIDAVNELFLETYKALGNDNDTGKA---------------NSSAIISMANYSNPQG 84 Query: 156 VNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILK----ILVSGGGKSRTG--- 208 + + + + R +NI LT G+ + + V+ + + Sbjct: 85 DSAFIDALVGFF-NRHYDWNLTSENIALTNGSQNAFFYLFNLFGGAFVNEHSQDKESKSV 143 Query: 209 ---VMIP-IPQYPLYSAV-ISELDAIQVNYYLDE-----ENCW---ALNVNELRRAVQEA 255 +++P P+Y YS V + V ++DE E + ++ L A Sbjct: 144 DKSILLPLTPEYIGYSDVHVEGQHFAAVLPHIDEVTHDGEEGFFKYRVDFEALENL--PA 201 Query: 256 KDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHS 315 +C P NPTG V + + + + A + L+ D Y Sbjct: 202 LKEGRIGAICCSRPTNPTGNVLTDEEMAHLAEIAKRYDIPLIIDNAYG----------MP 251 Query: 316 FKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL 375 F ++Y N + S SK +G G R G +I ++ + + +V Sbjct: 252 FPNIIYSDAHLNWDNNTIL-CFSLSK--IGLPGMRTG---IIVADAKVIEAVSAMNAVVN 305 Query: 376 CPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPG---IHC 432 P AA+ P+ + +Q S + K+A L L Q G + Sbjct: 306 LAPTRFGAAIA----TPLVANDRIKQLSD--NEIKPFYQKQATLAVKLLKQALGDYPLMI 359 Query: 433 NPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGF-------G 485 + +GA++ + + + L+ G +VP F Sbjct: 360 HKPEGAIFLW------------LWFKDLPISTLDLYERLKAKGTLIVPSEYFFPGVDVSD 407 Query: 486 QREGTYHFRMTILPPVEKLKTVLQKVKD 513 + RM+I + L ++ + + Sbjct: 408 YQHAHECIRMSIAADEQTLIDGIKVIGE 435 >4GDY-A nrPDB Length = 439 Score = 99.2 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 54/387 (13%), Positives = 129/387 (33%), Gaps = 66/387 (17%) Query: 133 KRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDG--GVPADPD----NIYLTTG 186 + +R LQ YS S G+ + + + + P ++ +T+G Sbjct: 66 EMMKRALQ---------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVN 246 + G+ + +++++ G V++ P Y + L +N DE ++ Sbjct: 117 SQQGLCKVFEMIINPGDN----VLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLR 172 Query: 247 EL----RRAVQEAKDHCDPKVLCII-NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 ++ + + PK L + N NPTG + + +++ A + ++ D+ Sbjct: 173 DILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDP 232 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y ++ +V + + V A S G+ G +I Sbjct: 233 YYFLQFNSG-------RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIE--- 282 Query: 362 EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTE 421 ++ + L P Q + ++ E E F + V+ + + Sbjct: 283 ---RVILHIQVSTLHPSTFNQLMISQLL-----HEWGEEGFMAHVDRVIDFYSNQKDAIL 334 Query: 422 DLFNQ-VPGI-HCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET----G 475 ++ + G+ + M+ + ++ + +L+EE G Sbjct: 335 AAADKWLTGLAEWHVPAAGMFLWIKV----------------KGINDVKELIEEKAVKMG 378 Query: 476 ICVVPGSGFGQREG--TYHFRMTILPP 500 + ++PG+ F + + R + Sbjct: 379 VLMLPGNAFYVDSSAPSPYLRASFSSA 405 >6HNV-A nrPDB Length = 524 Score = 97.7 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 73/441 (16%), Positives = 143/441 (32%), Gaps = 57/441 (12%) Query: 117 TYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPA 176 T P+ + +P + L Y+A +G + + +I R Sbjct: 98 TPPSSIHTPQSTVHISRHTTDPKLIDLARGL-QYAAVEGHAPLLQFARDFIIRTHKPNYD 156 Query: 177 DPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD 236 D N+++TTGASDG++ + + G +++ + + A V ++ Sbjct: 157 DW-NVFITTGASDGLNKAADVFLDDGD----VILVEEFTFSPFLRFSDNAGAKAVPVKIN 211 Query: 237 EENC-----WALNVNELRRAVQEAKDHCDPKVLCIINPG-NPTGQVQSRKCIEDVIHFAW 290 +N V+ L + + PK L I G NPTG QS + + + A Sbjct: 212 FDNDSDGIDLTQFVDLLENWEKHYPNLPKPKALYTIATGQNPTGFTQSLEFRKKIYDLAV 271 Query: 291 EEKLFLLADEVYQDNV---YSPDCRFHS----------------FKKVLYEMGPEYSSNV 331 + ++ D+ Y Y S K L E + Sbjct: 272 KYDFAIIEDDPYGYLTLPKYEKPNIGGSGSGNNELKNDLEIDDYLKNHLTPSYLELDTTG 331 Query: 332 ELASFHSTSKGYM--GECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMD--I 387 + + SK + G+ G+ EVI+ + + S V+ + Sbjct: 332 RVLRVETFSKLFAPGLRLGFIVGHKEVIDAVKNYSDVVNRGASGLTQTIVNNVIQENFKG 391 Query: 388 VVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFI 447 V + +S K+ +L ++ + + + + + M+ +I + Sbjct: 392 VDGWLEWILKMRLNYSYRKDLLLYSIFESQAYKKGYVDVID------PKAGMFVTFKINL 445 Query: 448 PAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG------SGFGQREGTYHFRMTI--LP 499 P + M + L GI VVPG F ++ + FR+ Sbjct: 446 PKDVDVLQK-------MKLLLWKLISYGILVVPGYNMTVDLEF-SKDRSNFFRLCYALAN 497 Query: 500 PVEKLKTVLQKVKDFHINFLE 520 E++ +++ D F Sbjct: 498 NDEEILESGKRLTDAVYEFFS 518 >6HNB-A nrPDB Length = 491 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 64/418 (15%), Positives = 126/418 (30%), Gaps = 51/418 (12%) Query: 129 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGAS 188 E KK A + Y ++ G+ + + + T VP + ++ ++ G + Sbjct: 84 EVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEH-TDMVHKVPYENWDVIVSVGNT 142 Query: 189 DGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNEL 248 + + L+ S G +++ + + V +DE + + +L Sbjct: 143 EAWDSTLRTFCSKGD----TILVEEYTFSSALESANGQGVNTVPVTMDE---FGIIPEKL 195 Query: 249 RRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDN--- 305 + + + I NPTG S + + + A + ++ DE Y Sbjct: 196 EELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKYDFLIIEDEPYYFLQME 255 Query: 306 VYSPDC---------RFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEV 356 Y+ D F K L + S SK G R G+ Sbjct: 256 TYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLDSFSKVLA--PGLRLGW--- 310 Query: 357 INLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKK 416 I ++ + V+L V + P A+ + + + K Sbjct: 311 IVGQKDLLERYVRLHEVSVQNPSGFSEALANALLRKWGHSGYLDWLI----GLRAEYTHK 366 Query: 417 AKLTEDLFNQVPG---IHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC-MKLLE 472 + D +Q NP M+ F +K + + + + + Sbjct: 367 RDVAIDALDQFVPKEVSSFNPPVAGMF-FTVTLDASKHPKYKEFLEDPLKVEAAVHEQAI 425 Query: 473 ETGICVVPGSGFGQREGTY----------------HFRMTILP-PVEKLKTVLQKVKD 513 + G + PGS F + FR T P+++L L+K Sbjct: 426 KQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEKFGK 483 >4JE5-A nrPDB Length = 503 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 68/422 (16%), Positives = 126/422 (29%), Gaps = 52/422 (12%) Query: 129 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGAS 188 +D ++ + Y S G + + + D D + T G + Sbjct: 87 KDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWD-VLATAGNT 145 Query: 189 DGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNEL 248 + + L++ + G +++ + ++ +A V + + + +L Sbjct: 146 NAWESTLRVFCNRGD----VILVEAHSFSS---SLASAEAQGVITFPVPIDADGIIPEKL 198 Query: 249 RRAVQEAKDH-CDPKVLCIINPG-NPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDN- 305 + ++ PK+L I G NPTG + E + A + ++ DE Y Sbjct: 199 AKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQ 258 Query: 306 --------------VYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRG 351 SP F K L + + S SK G R Sbjct: 259 MNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLA--PGTRL 316 Query: 352 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLG 411 G+ + +K L P Q ++ ++ E L Sbjct: 317 GW--ITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLK 374 Query: 412 NLAKKAKLTEDLFNQVPGIHCNPLQGAMY---AFPRIFIPAKAVEAAQAHQMAPDMFYCM 468 L + L + P+ G + + K + +Q+ + Sbjct: 375 RDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSL--YH 432 Query: 469 KLLEETGICVVPGSGFGQREGTY----------------HFRMTILP-PVEKLKTVLQKV 511 K++E G+ VVPGS F T FR T EKL L+++ Sbjct: 433 KVVER-GVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRL 491 Query: 512 KD 513 D Sbjct: 492 GD 493 >3G7Q-A nrPDB Length = 417 Score = 90.0 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 63/365 (17%), Positives = 120/365 (32%), Gaps = 65/365 (17%) Query: 169 RRDGGVPADPDNIYLTTGASDGISTILKILV-SGGGKSRTGVMIP-IPQYPLYSAVISEL 226 R G +P NI LT G+ + + S V+ P P+Y Y+ E Sbjct: 89 RETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEYIGYADSGLED 148 Query: 227 DA---IQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIE 283 D + N L E + +V+ + E ++C+ P NPTG V + + + Sbjct: 149 DLFVSARPNIELLPEGQFKYHVDFEHLHIGEETG-----MICVSRPTNPTGNVITDEELM 203 Query: 284 DVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGY 343 + A + + L+ D Y V P F E P ++ N+ L S SK Sbjct: 204 KLDRLANQHNIPLVIDNAYG--VPFPGIIFS-------EARPLWNPNIILCM--SLSK-- 250 Query: 344 MGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFS 403 +G G R G + + + ++ + + + E Sbjct: 251 LGLPGSRCGIIIAND---------------KTITAIANMNGIISLAPGGMGPAMMCEMIK 295 Query: 404 REKESVLGNLAKKAKLTEDLFNQVPGIH---------CNPLQGAMYAFPRIFIPAKAVEA 454 R L K + + + I + +GA++ + Sbjct: 296 RNDLLRLSETVIKPFYYQRVQQTIAIIRRYLSEERCLIHKPEGAIFLW------------ 343 Query: 455 AQAHQMAPDMFYCMKLLEETGICVVPGSGFGQ---REGTY---HFRMTILPPVEKLKTVL 508 + + L+ G+ +VPG F + + RM +P +K++ + Sbjct: 344 LWFKDLPITTELLYQRLKARGVLMVPGHYFFPGLDKPWPHTHQCMRMNYVPEPDKIEAGV 403 Query: 509 QKVKD 513 + + + Sbjct: 404 KILAE 408 >4EMY-A nrPDB Length = 413 Score = 89.2 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 68/388 (17%), Positives = 128/388 (32%), Gaps = 60/388 (15%) Query: 139 LQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPD---NIYLTTGASDGISTIL 195 L + + SY+ +G R+ V + P P+ + T G + I + + Sbjct: 64 LDEMDRSHIASYAPIEGEKDYRKIVIDTLFG-----PYKPEGYISAIATPGGTGAIRSAI 118 Query: 196 KILVSGGGKSRTGVMIPIPQY-PLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQE 254 + G +I Y Y + E + + +A N++ + A+ E Sbjct: 119 FSYLDEGDP-----LICHDYYWAPYRKICEEFGRNFKTFEF-FTDDFAFNIDVYKEAIDE 172 Query: 255 AKDHCDPKVLCIINP-GNPTGQVQSRKCIEDVIHF------AWEEKLFLLADEVYQDNVY 307 D I +P NPTG S + ++VI F ++K+ L+ D Y + Sbjct: 173 GIRDSDRIASLINSPGNNPTGYSLSDEEWDEVITFLKEKAEDKDKKITLIVDVAYLEFAG 232 Query: 308 SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGY---MEVINLHPEIK 364 D + F+K + P V S + Y G G E+I Sbjct: 233 DGDQQRKFFEK--FSNLPRNLFVVVAFSMSKSHTAYGLRSGAAVGISSSKEIIEEFEASL 290 Query: 365 GQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLF 424 + AA +I++ A E+ + + +E + L +A + Sbjct: 291 AHSARCNWSNGT-----HAAQNILIELERA--ENKKIYEQELVDLRNMLKSRADVFVTAA 343 Query: 425 NQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGF 484 + + P G + F + +A + D LE+ I +P Sbjct: 344 KENK-LTMIPYFGGFFTF---------IPTDKAFDIVKD-------LEKENIFTIP---- 382 Query: 485 GQREGTYHFRMTILP-PVEKLKTVLQKV 511 R+ I EK+ ++Q++ Sbjct: 383 ----SAKGIRVAICGVGEEKIPKLVQRL 406 >3RQ1-A nrPDB Length = 418 Score = 88.8 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 101/303 (33%), Gaps = 26/303 (8%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTG 208 Y+ G+ AA P T G + GI ++ G + Sbjct: 75 GYAPIAGIPDF--LCAAEKECFGNFRPEGHIRSIATAGGTGGIHHLIHNYTEPGDE---- 128 Query: 209 VMIPIPQYPLYSAVISELDAIQVNYYL-DEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 V+ + Y + S+ V Y L DE N + N + V E V+ Sbjct: 129 VLTADWYWGAYRVICSDTGRTLVTYSLFDEHNNF--NHEAFQNRVNELAAKQTNVVVIFN 186 Query: 268 NP-GNPTGQVQSRKCIEDVIHFAW------EEKLFLLADEVYQDNVYSPDCRFHSFKKVL 320 P NPTG K + +++F + + D Y D YS + + Sbjct: 187 TPGNNPTGYSIEDKDWDSILNFLKDLVAIGRNNVIIGIDVAYLD--YSGE---KDEVRAF 241 Query: 321 YEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL--VKLLSVRLCPP 378 + + +S SKG G R G M I+ EI + V + R Sbjct: 242 FNKFSHLPKEILTCVCYSLSKG-FTMYGQRVGAMIGISDDEEIADEFFEVNKSTSRATWS 300 Query: 379 VSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGA 438 + AM + N VA F+++ E+ + +A + + QV G+ P +G Sbjct: 301 NICRPAMRTMAN-IVADPAKFKEYEAERNCYYQLIRDRADIFKQEAAQV-GLPMLPYRGG 358 Query: 439 MYA 441 + Sbjct: 359 FFI 361 >4RAE-A nrPDB Length = 394 Score = 88.8 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 74/392 (18%), Positives = 125/392 (31%), Gaps = 54/392 (13%) Query: 96 GDAQAMGQQPITFLRQVMALCTYPNL-----LDSPSFPED----AKKRARRILQACGGNS 146 G + P+ + A P L L++ P R ++ + Sbjct: 6 GHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREAAID- 64 Query: 147 LGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSR 206 L Y + +R D+A Y+T + G+ +NI+ G+++ + +L+ G + Sbjct: 65 LHRY-PDRDAVALRADLAGYLTAQ-TGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAI 122 Query: 207 TGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCI 266 V P Y ++ + N + L+V+ AV + K P V+ I Sbjct: 123 GFV----PSYSMHPIISDGTHTE--WIEASRANDFGLDVDVAVAAVVDRK----PDVVFI 172 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 +P NP+GQ S + ++ A + DE Y + P + E Sbjct: 173 ASPNNPSGQSVSLPDLCKLLDVA---PGIAIVDEAYGEFSSQPSA---------VSLVEE 220 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMD 386 Y S + + S + G R GY +I I L+ L L QAA Sbjct: 221 YPSKLVVTRTMSKA---FAFAGGRLGY--LIATPAVIDAMLLVRLPYHLSS--VTQAAAR 273 Query: 387 IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIF 446 + S E+E N + G P F Sbjct: 274 AALRHSDDTLSSVAALIAERE-----------RVTTSLNDM-GFRVIPSDANFVLFGEFA 321 Query: 447 -IPAKAVEAAQAHQMAPDMFYCMKLLEETGIC 477 PA +A + D+ L TG+ Sbjct: 322 DAPAAWRRYLEAGILIRDVGIPGYLRATTGLA 353 >4R2N-A nrPDB Length = 367 Score = 87.7 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 54/353 (15%), Positives = 105/353 (29%), Gaps = 69/353 (19%) Query: 152 ASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMI 211 G ++ +A R G P+++ + G+ ++++ S G + V+ Sbjct: 56 PDNGCVQLKAALA-----RHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDE----VVF 106 Query: 212 PIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGN 271 + LY + AI + L + ++ + V + +++ + NP N Sbjct: 107 GWRSFELYPPQVRVAGAIPIQVPLTDHT---FDLYAMLATVTD-----RTRLIFVCNPNN 158 Query: 272 PTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNV 331 PT V + + L + DE Y + + + +NV Sbjct: 159 PTSTVVGPDALARFVEAVPAHILIAI-DEAYVEYIRDG-------MRPDSLGLVRAHNNV 210 Query: 332 ELASFHSTSKGYMG-ECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVN 390 + S + G G GY G+ +VI ++ V GQAA ++ Sbjct: 211 VVLRTFSKAYGLAGLRIGYAIGHPDVITALDKV--------YVPFTVSSIGQAAAIASLD 262 Query: 391 PPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAK 450 + E+ V L P A + + Sbjct: 263 AADELLARTDTVVAERARVSAELRAAGF-------------TLPPSQANFVW-------- 301 Query: 451 AVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEK 503 + ++ + I V P GT R+T+ P E Sbjct: 302 -------LPLGSRTQDFVEQAADARIVVRP-------YGTDGVRVTVAAPEEN 340 >3FTB-A nrPDB Length = 361 Score = 86.9 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 93/273 (34%), Gaps = 38/273 (13%) Query: 143 GGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGG 202 G +LG Y + + + Y+ +D G I L GAS+ I + + Sbjct: 51 GIKNLGVYPDVN-YRRLNKSIENYLKLKDIG-------IVLGNGASEIIELSISLF---- 98 Query: 203 GKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPK 262 ++I +P Y Y + V YLDE ++ ++ + D Sbjct: 99 ----EKILIIVPSYAEYEINAKKHGVSVVFSYLDE--NMCIDYEDIISKID------DVD 146 Query: 263 VLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYE 322 + I NP NP G + +++ V+ A E+K ++ DE + + P F K Sbjct: 147 SVIIGNPNNPNGGLINKEKFIHVLKLAEEKKKTIIIDEAFIEFTGDPSSSFVGEIK---- 202 Query: 323 MGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQ 382 N + G R GY I + EI ++ K + Sbjct: 203 -------NYSCLFIIRAMTKFFAMPGIRFGYG--ITNNKEIAAKI-KAKQNPWNINCFAE 252 Query: 383 AAMDIVVNPPVAGEESFEQFSREKESVLGNLAK 415 A + EES +E++ + L K Sbjct: 253 MAAINCLKDTNYIEESLLWIKKERKRFIEELNK 285 >2X5F-A nrPDB Length = 430 Score = 85.0 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 111/286 (38%), Gaps = 29/286 (10%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPAD-PDNIYLTTGASDGISTILKILVSGGGKSRTG 208 Y+ QG+ +R+ + R + + D +T + G+S + + V+ Sbjct: 84 YAPPQGIEELRDLWQQKMLRDNPELSIDNMSRPIVTNALTHGLSLVGDLFVNQDD----T 139 Query: 209 VMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIIN 268 +++P + Y V + + + Y + + L A+Q + D ++ + Sbjct: 140 ILLPEHNWGNYKLVFNTRNGANLQTYPIFDKDGHYTTDSLVEALQ--SYNKDKVIMILNY 197 Query: 269 PGNPTGQVQSRKCIEDVIHFAWE-----EKLFLLADEVYQDNVYSPDCRFHSFKKVLYEM 323 P NPTG + K + ++ K+ + D+ Y Y D S L + Sbjct: 198 PNNPTGYTPTHKEVTTIVEAIKALANKGTKVIAVVDDAYYGLFYE-DVYTQSLFTALTNL 256 Query: 324 GPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI---NLHPEIKGQLVK--LLSVRLCPP 378 +S+ + +K + G+R G+M E+ VK + S P Sbjct: 257 ---HSNAILPIRLDGATKEFFAW-GFRVGFMTFGTSDQTTKEVLEAKVKGLIRSNISSGP 312 Query: 379 VSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLF 424 + Q+A+ V+ ++ +QF +E E + L ++ ++T+++ Sbjct: 313 LPTQSAVKHVL-------KNNKQFDKEIEQNIQTLKERYEVTKEVV 351 >3FFH-A nrPDB Length = 363 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 91/262 (34%), Gaps = 39/262 (14%) Query: 158 CIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYP 217 +R++VA + + + + T G + I + ++L+ + T ++ P + Sbjct: 71 SLRKEVADFYQ-------LEEEELIFTAGVDELIELLTRVLLD----TTTNTVMATPTFV 119 Query: 218 LYS--AVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQ 275 Y A+I + ++ D E+ ++ + A+ E ++ I NP NPTG Sbjct: 120 QYRQNALIEGAEVREIPLLQDGEH----DLEGMLNAIDEKTT-----IVWICNPNNPTGN 170 Query: 276 VQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 I+ + + ++ DE Y + V + + L Sbjct: 171 YIELADIQAFLDRVP-SDVLVVLDEAYIEYVTPQPEKHEKLVRTYK----------NLII 219 Query: 336 FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG 395 + SK Y G R GY EI QL + + + A++ + + G Sbjct: 220 TRTFSKIY-GLASARVGYGI---ADKEIIRQLNIVRPPFNTTSIGQKLAIEAIKDQAFIG 275 Query: 396 --EESFEQFSREKESVLGNLAK 415 S ++ E+ K Sbjct: 276 ECRTSNANGIKQYEAFAKRFEK 297 >3EUC-A nrPDB Length = 367 Score = 81.9 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 65/328 (19%), Positives = 105/328 (32%), Gaps = 51/328 (15%) Query: 122 LDSPSFPEDAKKRARRILQACGGN-SLGSYSASQGVNCIREDVAAYITRRDGGVPADPDN 180 LD+ P R L A G +L Y +R + + G Sbjct: 35 LDAMENPYRLPPALRSELAARLGEVALNRYPVPSSE-ALRAKLKEVMQVPAGM------E 87 Query: 181 IYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC 240 + L G+ + IS + G K VM P+P + +Y+ V L Sbjct: 88 VLLGNGSDEIISMLALAAARPGAK----VMAPVPGFVMYAMSAQFAGLEFVGVPLRA--D 141 Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE--KLFLLA 298 + L+ R A+ A P ++ + P NPTG + +E ++ A + ++ Sbjct: 142 FTLD----RGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQGSVCRSLVVV 197 Query: 299 DEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVIN 358 DE YQ S+ L + G L + SK +G G R GY + Sbjct: 198 DEAYQ------PFAQESWMSRLTDFG-------NLLVMRTVSK--LGLAGIRLGY---VA 239 Query: 359 LHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAK 418 P+ QL K+ V +A + +E Q E+ V +A Sbjct: 240 GDPQWLEQLDKVRP-PYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAH-- 296 Query: 419 LTEDLFNQVPGIHCNPLQGAMYAFPRIF 446 G A + R+ Sbjct: 297 ----------GGVTVFPSAANFLLARVP 314 >3G0T-A nrPDB Length = 437 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 31/207 (14%), Positives = 64/207 (30%), Gaps = 10/207 (4%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y G+ ++++ A+ + + T G+ G + G Sbjct: 78 YPNLDGLPELKQE-ASRFAKLFVNIDIPARACVPTVGSMQGCFVSFLVANRTHKNREYGT 136 Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 + P + L L + + + +LR ++ + NP Sbjct: 137 LFIDPGFNLNKLQCRILGQK-----FESFDLFEYRGEKLREKLESYLQTGQFCSIIYSNP 191 Query: 270 GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSS 329 NPT Q + + + + A + + ++ D Y + D + Y+ Sbjct: 192 NNPTWQCMTDEELRIIGELATKHDVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVA-NYTD 250 Query: 330 NVELASFHSTSKGYMGECGYRGGYMEV 356 N LA S + Y G R G + + Sbjct: 251 NYILALSSSKAFSYA---GQRIGVLMI 274 >1LC8-A nrPDB Length = 364 Score = 77.3 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 63/382 (16%), Positives = 113/382 (29%), Gaps = 66/382 (17%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGA 187 P K+ L Y + + +A R VPA I G Sbjct: 39 PVSVKRALIDNLDCIERYPDADYFH------LHQALA-----RHHQVPASW--ILAGNGE 85 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 ++ I T V+ G K R +++ P + Y +++ + L E + W L Sbjct: 86 TESIFT-----VASGLKPRRAMIV-TPGFAEYGRALAQSGCEIRRWSLREADGWQLTDAI 139 Query: 248 LRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 L D L + P NPTG + R ++ + + L+ DE Sbjct: 140 LEAL------TPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILDEA------ 187 Query: 308 SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL 367 F F P N + S +K + G R GY+ + Sbjct: 188 -----FIDFIPHETGFIPALKDNPHIWVLRSLTK-FYAIPGLRLGYL--------VNSDD 233 Query: 368 VKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQV 427 + +R A+ + + +++Q + L ++ Q+ Sbjct: 234 AAMARMRRQQMPWSVNALAALAGEVALQDSAWQQ------ATWHWLREEGARFYQALCQL 287 Query: 428 PGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQR 487 P + P + A Y R D+ +LL + + + G Sbjct: 288 PLLTVYPGR-ANYLLLRCE--------------REDIDLQRRLLTQRILIRSCANYPGLD 332 Query: 488 EGTYHFRMTILPPVEKLKTVLQ 509 Y + E+L L+ Sbjct: 333 SRYYRVAIRSAAQNERLLAALR 354 >1UU1-A nrPDB Length = 335 Score = 71.9 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 56/296 (18%), Positives = 92/296 (31%), Gaps = 50/296 (16%) Query: 127 FPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTG 186 FPED R L + + E + +Y+ +N+ + G Sbjct: 33 FPEDLVDEVFRRLNSDALRIYYDSPDE----ELIEKILSYLDTDF----LSKNNVSVGNG 84 Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVN 246 A + I ++ + V P P Y Y + A + L ++ Sbjct: 85 ADEIIYVMMLMF-------DRSVFFP-PTYSCYRIFAKAVGAKFLEVPLTKDLRI----- 131 Query: 247 ELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNV 306 + + V+ I NP NPTG V R+ IE ++ + F+ DE Y + Sbjct: 132 -------PEVNVGEGDVVFIPNPNNPTGHVFEREEIERIL----KTGAFVALDEAYYE-- 178 Query: 307 YSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQ 366 FH V + E LA + SK R GY V+ I Sbjct: 179 ------FHGESYVDFLKKYEN-----LAVIRTFSKA-FSLAAQRVGY--VVASEKFIDAY 224 Query: 367 LVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 L + Q + ++ EE + E+E + L + D Sbjct: 225 NRVRLPFNV--SYVSQMFAKVALDHREIFEERTKFIVEERERMKSALREMGYRITD 278 >3FKD-A nrPDB Length = 350 Score = 71.5 bits (173), Expect = 9e-13, Method: Composition-based stats. Identities = 56/364 (15%), Positives = 102/364 (28%), Gaps = 76/364 (20%) Query: 159 IREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPL 218 +R+ +A D + I +T G + I + + +I IP + Sbjct: 55 LRQMLAKR-------NSVDNNAILVTNGPTAAFYQIAQAF------RGSRSLIAIPSFAE 101 Query: 219 YSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQS 278 Y + Y +E+ D + + NP NP G++ Sbjct: 102 YEDACRMYEHEVCFYPSNEDIG--------------EADFSNMDFCWLCNPNNPDGRLLQ 147 Query: 279 RKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHS 338 R I +++ + D+ Y SF + L +S Sbjct: 148 RTEILRLLN--DHPDTTFVLDQSY-----------VSFTTEEVIRPADIKGRKNLVMVYS 194 Query: 339 TSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEES 398 S Y G G R GY+ +K ++ P A + + Sbjct: 195 FSHAY-GIPGLRIGYIVANK-------DFMKRVAAFSTP----WAVNALAIEAAKFILIH 242 Query: 399 FEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAH 458 QF+ + + N++ G+ +P + Sbjct: 243 PAQFTLP----IRKWQRNTVDFITALNRLDGVEVHPSGTTFFLL--------------RL 284 Query: 459 QMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINF 518 + +LEE + + S F + + R+T P + Q F Sbjct: 285 KKGTAAELKKYMLEEYNMLIRDASNFRGLD-ESYVRITTQRPAQN-----QLFIKALETF 338 Query: 519 LEKY 522 LEKY Sbjct: 339 LEKY 342 >3GET-A nrPDB Length = 365 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 87/277 (31%), Gaps = 35/277 (12%) Query: 142 CGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSG 201 N Y + ++ +A +NI + G+ I + ++ Sbjct: 54 QNANKAHLYPDDSMI-ELKSTLAQKYK-------VQNENIIIGAGSDQVIEFAIHSKLN- 104 Query: 202 GGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDP 261 S+ + + +Y + A + N++E ++ + KD Sbjct: 105 ---SKNAFLQAGVTFAMYEIYAKQCGAK-----CYKTQSITHNLDEFKKLYETHKDE--I 154 Query: 262 KVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY 321 K++ + P NP G+ + I E+ L ++ D Y + D + H Sbjct: 155 KLIFLCLPNNPLGECLDASEATEFIKGVNEDCLVVI-DAAYNEFASFKDSKKH------- 206 Query: 322 EMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSG 381 E + + T G G R GY + I KL + ++ Sbjct: 207 LEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGI---ANANIISAFYKLRAPFNVSNLAL 263 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAK 418 +AA+ + +E E+ S + + AK Sbjct: 264 KAAVAAM-----DDDEFTEKTLENNFSQMELYKEFAK 295 >4WD2-A nrPDB Length = 408 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 103/358 (28%), Gaps = 26/358 (7%) Query: 131 AKKRARRILQACGGNSLGSYSASQGVNCIREDVAAY-ITRRDGGVPADPDNIYLTTGASD 189 A + A LQ G Y G+ R+ V + A T G S Sbjct: 56 AVREAETALQRDSGPK--PYLPMVGLAAYRDAVQSLVFGADHPARAAGRIATLQTLGGSG 113 Query: 190 GISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELR 249 + L S+ V + P + + + Y +E L + + Sbjct: 114 ALKVGADFLKRYFPDSQ--VWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAML 171 Query: 250 RAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSP 309 A+ + NPTG E +I +L D YQ Sbjct: 172 AAIDALPARSIVLLHACC--HNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGL 229 Query: 310 DCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI----NLHPEIKG 365 D + +++ V +S SK G R G + V+ + G Sbjct: 230 DADAFAVRELAR-------RGVPTLVANSFSKN-FSLYGERVGGLSVVCEDAAAAERVLG 281 Query: 366 QLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLF- 424 QL + P + A + V A + +E+ E ++ +A+ + D Sbjct: 282 QLAGAVRSNYSNPQTYGAKVVAAVLGTPALRKQWEE---ELSAMCRRIARMRQSIHDGLR 338 Query: 425 NQVPGI---HCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 + V G +G A+ + C+ L ++ + +V Sbjct: 339 DHVSGEALTRYVKQRGMFTYTGLTESQVDALREVHGVYILRSGRMCVAGLNDSNVGIV 396 >1AY8-A nrPDB Length = 394 Score = 68.0 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 36/283 (12%), Positives = 81/283 (28%), Gaps = 19/283 (6%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGV 209 Y+ G ++ + I G+ ++ T G + + L+ ++ V Sbjct: 65 YAGLSGEPEFQKAMGELI--LGDGLKSETTATLATVGGTGALRQALE--LARMANPDLRV 120 Query: 210 MIPIPQYPLYSAVISELDA-IQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIIN 268 + P +P + ++++ + +Q Y D E ++ ++ + AK + Sbjct: 121 FVSDPTWPNHVSIMNFMGLPVQTYRYFDAETR-GVDFEGMKADLAAAKKGDMVLLHGCC- 178 Query: 269 PGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYS 328 NPTG + ++ + L D YQ + Sbjct: 179 -HNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGF----GDGLEEDAAGTRLIASRIP 233 Query: 329 SNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLV--KLLSVRLCPPVSGQAAMD 386 + AS Y G +G + + P + Sbjct: 234 EVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVST 293 Query: 387 IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPG 429 ++ P E + E E+V + + + + G Sbjct: 294 VLTTP-----ELRADWMAELEAVRSGMLRLREQLAGELRDLSG 331 >5X03-B nrPDB Length = 365 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 45/316 (14%), Positives = 108/316 (34%), Gaps = 36/316 (11%) Query: 123 DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 D+ FP + R + + +LG S QG+ +R + I GV P+ + Sbjct: 11 DTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITRLI-SLTRGVKCRPEQMI 69 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 + G + + +L L+ + P Y ++ LDE+ Sbjct: 70 IGAG-TQVLMQLLTELL----PKEAVYAMEEPGYRRMYQLLKNAGKQVKTIMLDEK---G 121 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGN--PTGQVQSRKCIEDVIHF-AWEEKLFLLAD 299 +++ E+ R + + + P + P+G + ++++ A E + +++ D Sbjct: 122 MSIAEITRQQPD---------VLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYIIED 172 Query: 300 EVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 + + Y D + + NV S S G R YM + Sbjct: 173 DYDSEFTYDVDS-------IPALQSLDRFQNVIYMGTFSKSL----LPGLRISYMVLPPE 221 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG--EESFEQFSREKESVLGNLAKKA 417 ++ + ++ C ++ + + + ++ + + ++E ++ L + Sbjct: 222 L--LRAYKQRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEF 279 Query: 418 KLTEDLFNQVPGIHCN 433 + G+H Sbjct: 280 SGEVTVKGANAGLHFV 295 >4N0B-A nrPDB Length = 479 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 45/316 (14%), Positives = 108/316 (34%), Gaps = 36/316 (11%) Query: 123 DSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 182 D+ FP + R + + +LG S QG+ +R + I GV P+ + Sbjct: 118 DTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITRLI-SLTRGVKCRPEQMI 176 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 + G + + +L L+ + P Y ++ LDE+ Sbjct: 177 IGAG-TQVLMQLLTELL----PKEAVYAMEEPGYRRMYQLLKNAGKQVKTIMLDEK---G 228 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGN--PTGQVQSRKCIEDVIHF-AWEEKLFLLAD 299 +++ E+ R + + + P + P+G + ++++ A E + +++ D Sbjct: 229 MSIAEITRQQPD---------VLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYIIED 279 Query: 300 EVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 + + Y D + + NV S S G R YM + Sbjct: 280 DYDSEFTYDVDS-------IPALQSLDRFQNVIYMGTFSKSL----LPGLRISYMVLPPE 328 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG--EESFEQFSREKESVLGNLAKKA 417 ++ + ++ C ++ + + + ++ + + ++E ++ L + Sbjct: 329 L--LRAYKQRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEF 386 Query: 418 KLTEDLFNQVPGIHCN 433 + G+H Sbjct: 387 SGEVTVKGANAGLHFV 402 >3FSL-A nrPDB Length = 397 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 56/306 (18%), Positives = 103/306 (33%), Gaps = 26/306 (8%) Query: 131 AKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGV-PADPDNIYLTTGASD 189 A A L A + Y +G+NC R +A + D V T G S Sbjct: 48 AVAEAEARLNAQP-HGASLYLPMEGLNCYRHAIAPLLFGADHPVLKQQRVATIQTLGGSG 106 Query: 190 GISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELR 249 + L +S V + P + + A+ + Y +E + N+L Sbjct: 107 ALKVGADFLKRYFPESG--VWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLL 164 Query: 250 RAVQEAKDHCDPKVLCIINP--GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY 307 ++ + + +++P NPTG + + VI +L D YQ Sbjct: 165 ATLKTLQAGS----IVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGF-- 218 Query: 308 SPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL 367 ++ Y + S+ + +S SK G R G + V+ E G++ Sbjct: 219 -----GAGMEEDAYAIRAIASAGLPALVSNSFSKI-FSLYGERVGGLSVMCEDAEAAGRV 272 Query: 368 -----VKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 + PP G + V+N ++ + + LA + +L + Sbjct: 273 LGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLKEVEEMRTRI---LAMRQELVKV 329 Query: 423 LFNQVP 428 L ++P Sbjct: 330 LSTEMP 335 >6C3C-A nrPDB Length = 413 Score = 66.1 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 64/368 (17%), Positives = 114/368 (30%), Gaps = 50/368 (13%) Query: 150 YSASQGVNCIRED--VAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRT 207 Y A +G+ E A+ + L+ AS L K R Sbjct: 75 YEAEEGLQATYEKRFTEAFFQLHRQPTALVKNKTMLSYAASISTMVAGMFL----KKERL 130 Query: 208 GVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 V + P + V++ +D V Y +E+ + ++ R E + L ++ Sbjct: 131 AVTLIEPCFDNLYDVLANMD---VPLYPIDESVFY----DVDRIYPELERRVRTDALFLV 183 Query: 268 NPGNPTGQVQ---SRKCIEDVIHFAWEEKLFLLADEVYQDNV-YSPDCRFHSFKKVLYEM 323 +P NPTG RK E+V+ F + LL D + + P+ ++L Sbjct: 184 DPNNPTGFSLLRHGRKGFEEVVRFCKDHDKLLLIDFCFASFTLFEPELARFDMYELLENS 243 Query: 324 GPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQA 383 G Y + + T +C +I +I + L V Sbjct: 244 GVRY---LAIEDTGKTWPVQDAKC-------ALITASDDIWETV-----YNLHTSVLLNV 288 Query: 384 AMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFP 443 + ++ +S SV L + + + + P+ A+ Sbjct: 289 SPFVLNMLTQYVRDSAAD---RLASVREVLTRNRECARKTLDGSILEYQEPVVKVSVAWF 345 Query: 444 RIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQRE---GTYHFRMTILPP 500 R+ P +LL G+ V+PG F E G + RM + Sbjct: 346 RVDHPELTATD------------VHRLLSADGVYVLPGRYFYWSEPSKGDAYVRMALARE 393 Query: 501 VEKLKTVL 508 E + Sbjct: 394 PEMFADAM 401 >4RKC-A nrPDB Length = 398 Score = 66.1 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 109/316 (34%), Gaps = 23/316 (7%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPAD-PDNIYLTTGASDGISTILKILVSGGGKSRTG 208 Y G+ R+ + +D V D T G S + + + +S+ Sbjct: 65 YLPMAGLPGHRKGCQELLFGKDAPVLKDGLVATIATIGGSGALKVGAEFIHEWFPQSKCY 124 Query: 209 VMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIIN 268 V P + + A+ D Y + + +E+ + + + +++ Sbjct: 125 VS--DPTWGNHIAIFEGCDIEVGKYPYYDTATGGIKFDEMIAFF----ETLNKDDVLLLH 178 Query: 269 P--GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 P NPTG +R+ + V++ E +L D YQ D ++ +K + Sbjct: 179 PCCHNPTGVDLTREQWDTVLNVIQERELIPFMDIAYQGFGEDMDSDAYAIRKAV------ 232 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL-----CPPVSG 381 + L +S SK + G R G + V+ + ++ L+ + PP G Sbjct: 233 -DMGLPLFVSNSFSKN-LSLYGERVGGLSVVCPTVDETERVFGQLNSTVRRIYSSPPSHG 290 Query: 382 QAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA 441 +DIV+N E+ + ++ + ++ K K + Q M++ Sbjct: 291 GRVVDIVMNDAALHEQWVGEVYAMRD-RIKSMRTKLKSVLEAKISGRNFDYLTAQNGMFS 349 Query: 442 FPRIFIPAKAVEAAQA 457 F + ++ Sbjct: 350 FTGLTPEQVERLQSEF 365 >3HDO-A nrPDB Length = 360 Score = 65.7 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 65/390 (16%), Positives = 104/390 (26%), Gaps = 79/390 (20%) Query: 125 PSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLT 184 P PE K + G +L Y S +RE DP I + Sbjct: 39 PPSPEVVKAILEEL--GPDGAALRIY-PSASSQKLREVAGELYG-------FDPSWIIMA 88 Query: 185 TGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALN 244 G+ + ++ +++ + G + + P Y Y + A + L + A Sbjct: 89 NGSDEVLNNLIRAFAAEGEE----IGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGF 144 Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 KV + P P G +E + A L+ DE Y + Sbjct: 145 PERYEG-----------KVFFLTTPNAPLGPSFP---LEYIDELARRCAGMLVLDETYAE 190 Query: 305 NVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGE-CGYRGGYMEVINLHPEI 363 F + NV + S S G G EVI +I Sbjct: 191 -----------FAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKI 239 Query: 364 KGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDL 423 + QAA + E + +E L Sbjct: 240 RDHYNLDR--------LAQAACVAALRDQAYLSECCRRIRETREWFTTELRS-------- 283 Query: 424 FNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSG 483 G P QG Y F + + D Y K+L Sbjct: 284 ----IGYDVIPSQGN-YLFA--------TPPDRDGKRVYDGLYARKVLVRH--------- 321 Query: 484 FGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 F + R++I E ++ L +K+ Sbjct: 322 FSDPLLAHGMRISIGTREE-MEQTLAALKE 350 >4WB0-B nrPDB Length = 414 Score = 65.7 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 50/335 (14%), Positives = 114/335 (34%), Gaps = 47/335 (14%) Query: 128 PEDAKKRARRILQACGGNS---LGSYSASQGVN----CIRED---------------VAA 165 P+ + A+R A G + +G+Y QG+ +R+ ++ Sbjct: 23 PDPIFELAKRAAAAKGPKANLVIGAYRDEQGLPYPLRVVRKAEQLLLDMNLNYEYLPISG 82 Query: 166 Y------ITRRDGGVPADPDNIYL--TTGASDGISTILKILVSGGGKSRTGVMIPIPQYP 217 Y + G + +N+ T + +S K+L +T + + P +P Sbjct: 83 YQPFIDEAVKMTYGDTVELENLVAVQTLSGTGALSLGAKLLTHVFDAEKTPIYLADPTWP 142 Query: 218 LYSAVISELDAIQVNYYLDEEN-CWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQV 276 + +++ + Y ++ L+ +++ + A D L NPTG Sbjct: 143 NHYSIVKAAGWKDIRTYAYYDHKTLGLDFEGMKKDILAAPDGSV--FLLHQCAHNPTGVD 200 Query: 277 QSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASF 336 S++ ++ + + D YQ S Y +E+ Sbjct: 201 PSQEQWNEIASLMLAKHHQVFFDSAYQGYASG------SLDTDAYAARLFARRGIEVLLA 254 Query: 337 HSTSKGYMGECGYRGGYMEVI----NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPP 392 S SK MG R G + ++ ++K + L+ P + A + ++ Sbjct: 255 QSFSKN-MGLYSERAGTLSLLLKDKTKRADVKSVMDSLIRAEYTCPPAHGARLAHLI--- 310 Query: 393 VAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQV 427 ++ E +++ E ++ + + D ++ Sbjct: 311 LSNNELRKEWEAELSAMAERIRTMRRTVYDELLRL 345 >4WBT-A nrPDB Length = 376 Score = 63.8 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 58/389 (14%), Positives = 114/389 (29%), Gaps = 68/389 (17%) Query: 128 PEDAKKRARRILQACGGNSLGSYSASQG-VNCIREDVAAYITRRD-----------GGVP 175 PE +++ R + A G + + + + IR+ D + Sbjct: 26 PEALERQHGRKIAARIGANESGFGPAPSVLLAIRQAAGDTWKYADPENHDLKQALARHLG 85 Query: 176 ADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 P NI + G + I++++V G T + YP ++ ++ V Sbjct: 86 TSPANIAIGEGIDGLLGQIVRLVVEAGAPVVTSLG----GYPTFNYHVAGHGGRLVTVP- 140 Query: 236 DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 +A + +L + P ++ + NP NP G + + E L Sbjct: 141 -----YADDREDLEGLLAAVGRENAP-LVYLANPDNPMGSWWPAERVVAFAQALPETTLL 194 Query: 296 LLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 +L DE Y + P + ++ + + + SK Y G G R GY Sbjct: 195 VL-DEAYCETA--PRDALPPIESLIDKPN--------VIRARTFSKAY-GLAGARIGYT- 241 Query: 356 VINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAK 415 L Q + M + + + + +E + N + Sbjct: 242 ---LSTPGTAQAFDKIRNHF--------GMSRIGVAAAIAALADQDYLKEVTLKIANSRQ 290 Query: 416 KAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETG 475 + G+ + A A +L+ + G Sbjct: 291 RI----GRIAADSGLAPL-PSATNFVAVDCGKDASYARA-----------IVDRLMSDHG 334 Query: 476 ICV-VPGSGFGQREGTYHFRMTILPPVEK 503 I + +PG R++ P E Sbjct: 335 IFIRMPGVA----PLNRCIRISTAPDAEM 359 >3BWN-A nrPDB Length = 391 Score = 62.2 bits (149), Expect = 6e-10, Method: Composition-based stats. Identities = 52/364 (14%), Positives = 110/364 (30%), Gaps = 63/364 (17%) Query: 157 NCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQY 216 + + + + G + I + TG++ + L S V+ P Y Sbjct: 71 PELEDAI-KDLHGVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQPVSVVAAAPFY 129 Query: 217 PLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQV 276 Y + E ++ Y E + W + P + + +P NP G + Sbjct: 130 STY---VEETTYVRSGMYKWEGDAWGFD-------------KKGPYIELVTSPNNPDGTI 173 Query: 277 QSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASF 336 E V++ +++ ++ D Y Y+P R ++ L +F Sbjct: 174 -----RETVVNRPDDDEAKVIHDFAYYWPHYTPITR-------------RQDHDIMLFTF 215 Query: 337 HSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGE 396 + G G R G+ V + K K++ + + + + Sbjct: 216 SKIT----GHAGSRIGWALVKD-----KEVAKKMVEYIIVNSIGVSKESQVRTAKILNVL 266 Query: 397 ESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA--FPRIFIPAKAVEA 454 + + E E+ + K + +V A +P F Sbjct: 267 KETCKSESESENFFKYGREMMKNRWEKLREV-----VKESDAFTLPKYPEAFCNYFGKSL 321 Query: 455 AQAHQMA-----PDMFYCMKLLEETGICVVPGSGFGQREGTY--HFRMTILPPVEKLKTV 507 A + + L + S G+R G+ H R+++L + Sbjct: 322 ESYPAFAWLGTKEETDLVSE-LRRHKVM----SRAGERCGSDKKHVRVSMLSREDVFNVF 376 Query: 508 LQKV 511 L+++ Sbjct: 377 LERL 380 >2CST-A nrPDB Length = 411 Score = 61.5 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 94/323 (29%), Gaps = 26/323 (8%) Query: 130 DAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI--YLTTGA 187 ++ +++ G Y G+ R A+ I D + G Sbjct: 50 PVVRKVEQLIAGDGS-LNHEYLPILGLPEFR-ANASRIALGDDSPAIAQKRVGSVQGLGG 107 Query: 188 SDGIST---ILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALN 244 + + L+ +G + T V + P + +++V + + Y W Sbjct: 108 TGALRIGAEFLRRWYNGNNNTATPVYVSSPTWENHNSVFMDAGFKDIRTY----RYWDAA 163 Query: 245 VN--ELRRAVQEAKDHCDPKVLCI-INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 +L+ + + + + + + NPTG + + + LF D Sbjct: 164 KRGLDLQGLLDDMEKAPEFSIFILHACAHNPTGTDPTPDEWKQIAAVMKRRCLFPFFDSA 223 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 YQ + + G E S SK G R G + V+ Sbjct: 224 YQGFASGSLDKDAWAVRYFVSEGFELFCA------QSFSKN-FGLYNERVGNLSVVGKDE 276 Query: 362 E----IKGQLVKLLSVRLCPPVSGQAAMDI-VVNPPVAGEESFEQFSREKESVLGNLAKK 416 + + Q+ K++ P S A + + P E + + VL ++ Sbjct: 277 DNVQRVLSQMEKIVRTTWSNPPSQGARIVATTLTSPQLFAEWKDNVKTMADRVLLMRSEL 336 Query: 417 AKLTEDLFNQVPGIHCNPLQGAM 439 E L H G Sbjct: 337 RSRLESLGTPGTWNHITDQIGMF 359 >5DJ3-A nrPDB Length = 376 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 48/348 (13%), Positives = 101/348 (29%), Gaps = 61/348 (17%) Query: 173 GVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVN 232 G PA+P + +S ++IL S V + P + + ++ V Sbjct: 76 GYPAEPGRVLSCYSSS----VSMEILARSLSASVDRVALVHPTFDNIADLLRGNGLDLVP 131 Query: 233 YYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE 292 D + L+ L + + P NPTG+V + + + + E Sbjct: 132 VEEDALHGADLSAELL----------SSVGCVFVTTPNNPTGRVLAEERLRRLAEQCAEH 181 Query: 293 KLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGG 352 L D ++ + VL E G + V + Sbjct: 182 GTVLALDTSFRGF---DAAAHYDHYAVLQEAGCRW---VVIEDTGKL------------- 222 Query: 353 YMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREK-----E 407 + + ++K L+ P + DI++ +FSR+ Sbjct: 223 WPTL-----DLKAGLLVFSEDIGLP--VEKIYSDILLGVSPLILALIREFSRDAADGGLA 275 Query: 408 SVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYC 467 + + + V G+ + +++ A Sbjct: 276 DLHAFILHNRSVVRRALAGVEGVSFPDPE------------SRSSVERVAFAGRTGTEVW 323 Query: 468 MKLLEETGICVVPGSGFGQRE---GTYHFRMTILPPVEKLKTVLQKVK 512 + L+ + +P F E G + R+ + E L+ +Q ++ Sbjct: 324 EE-LQRHHVFALPCRQFHWAEPSDGDHMVRIALSRSTEPLEKSVQVLR 370 >3PD6-B nrPDB Length = 401 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 42/305 (13%), Positives = 91/305 (29%), Gaps = 14/305 (4%) Query: 140 QACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILV 199 Q N Y G+ + A + V + + T + G + + Sbjct: 57 QIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFL 116 Query: 200 SGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHC 259 K V +P P + ++ + + Y + + + + + + Sbjct: 117 QRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQS 176 Query: 260 DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKV 319 +L NPTG + +++ ++ LF D YQ + + Sbjct: 177 V--LLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRH 234 Query: 320 LYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE----IKGQLVKLLSVRL 375 E G + + S +K MG G R G V+ E ++ QL L+ Sbjct: 235 FIEQG------INVCLCQSYAKN-MGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLY 287 Query: 376 CPPVSGQAAMDI-VVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNP 434 P A + ++ P ++ ++ + ++ + + + H Sbjct: 288 SNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITD 347 Query: 435 LQGAM 439 G Sbjct: 348 QIGMF 352 >6EZL-A nrPDB Length = 404 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 105/309 (33%), Gaps = 26/309 (8%) Query: 127 FPEDAKKRARRILQACGGNSLGSYSASQGV-NCIREDVAAYITRRDGGVPADPDNIYLTT 185 +P + ++A + L N+ Y G I E + + G +N+ Sbjct: 48 YPLNVVRKAEQRL--LEMNADKEYLPMSGYAPFIEESL-----KIAYGDSVARENVVGIQ 100 Query: 186 GASD-GISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWAL- 243 G S G +I ++ T V I P +P + AV++ + + Y +N Sbjct: 101 GLSGTGSLSIGACFLARVLSRDTPVYISDPTWPNHYAVMAAANLTDLRKYRYYDNAKRCI 160 Query: 244 NVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 + + L + A + + NPTG + + ++ +L D YQ Sbjct: 161 DFDGLLEDLNGAPEGSIVILHACA--HNPTGMDPTHEQWAKILEVFQARRLIPFFDSAYQ 218 Query: 304 DNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE- 362 S Y + +E+ S SK MG R G ++ +P+ Sbjct: 219 GY------ATGSLDNDAYSIRLFARQGMEMLLAQSYSKN-MGLYAERVGVCSIVTANPKK 271 Query: 363 ---IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 IK QL ++ + P + A + +V +EQ E + + + + Sbjct: 272 APLIKSQLETIVRSQYSTPPAHGARVAYLVLSDPELRAGWEQ---ELRVMSTRVLEMRQA 328 Query: 420 TEDLFNQVP 428 D ++ Sbjct: 329 LYDGLKRLG 337 >3MEB-A nrPDB Length = 448 Score = 58.4 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 99/311 (31%), Gaps = 28/311 (9%) Query: 130 DAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY--LTTGA 187 A K A I+ + Y G E A ++ A I + Sbjct: 70 PAVKEAEAIISSDLSKYNKEYPPVAGFPLFLEA-AQFLMFGKDSKAAQEGRIASCQSLSG 128 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYP-LYSAVISELDAIQVNY----YLDEENCWA 242 + + + L + +P +P Y + ++V Y YL ++ Sbjct: 129 TGSLHIGFEFL--HLWMPKAEFYMPSTTWPNHYGIYDKVFNKLKVPYKEYTYLRKDGELE 186 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 ++ + ++ +Q A + L NP+G + ++++ E+K D Y Sbjct: 187 IDFSNTKKDIQSAPEKS--IFLFHACAHNPSGIDFTEAQWKELLPIMKEKKHIAFFDSAY 244 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 Q SF+ + + + VE+ S SK G G R G + V++ E Sbjct: 245 QGF------ATGSFEADAFAVRMFVDAGVEVLVAQSFSKN-FGLYGERIGCLHVVHAGVE 297 Query: 363 IKGQLVKLLSVRLCPPVSGQAAM---------DIVVNPPVAGEESFEQFSREKESVLGNL 413 + K LS + ++ Q +V V + + F + + + Sbjct: 298 GSVEKNKALSAAMVSGMTLQIRKTWSMSAIHGAYIVQVIVHDKRLLQMFYDNVKEMSARI 357 Query: 414 AKKAKLTEDLF 424 + L Sbjct: 358 HRMRSLLHASL 368 >4F5M-A nrPDB Length = 406 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 45/334 (13%), Positives = 98/334 (29%), Gaps = 23/334 (6%) Query: 131 AKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPD-NIYLTTGASD 189 + K+A + L + +Y G+ + + + D T G + Sbjct: 58 SVKKAEQYL--LENETTKNYLGIDGIPEFGRCTQELLFGKGSALINDKRARTAQTPGGTG 115 Query: 190 GISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELR 249 + L S V + P +P + +V + Y + L+ + L Sbjct: 116 ALRVAADFLAK--NTSVKRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALI 173 Query: 250 RAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSP 309 ++ EA+ NPTG + + + + + E+ L D YQ Sbjct: 174 NSLNEAQAGDVVLFHGCC--HNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGL 231 Query: 310 DCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQL-- 367 + + + +AS +S + G E R G ++ E + Sbjct: 232 EEDAEGLRAF-----AAMHKELIVASSYSKNFGLYNE---RVGACTLVAADSETVDRAFS 283 Query: 368 -VKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQ 426 +K A VV ++ + + +E + + + +L + + Sbjct: 284 QMKAAIRANYSNPPAHGA--SVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQE 341 Query: 427 VPG---IHCNPLQGAMYAFPRIFIPAKAVEAAQA 457 Q M++F + + Sbjct: 342 KGANRDFSFIIKQNGMFSFSGLTKEQVLRLREEF 375 >4H51-A nrPDB Length = 420 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 51/324 (15%), Positives = 110/324 (33%), Gaps = 30/324 (9%) Query: 113 MALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQG-VNCIREDVAAYITRRD 171 + + Y + P +P ++A ++L + Y G I E V + Sbjct: 49 LVIGAYRDEQGRP-YPLRVVRKAEQLLLDMNLDYE--YLPISGYQPFIDEAV-----KII 100 Query: 172 GGVPADPDNIYL--TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAI 229 G + +N+ T + +S K+L T + + P +P + V+ Sbjct: 101 YGNTVELENLVAVQTLSGTGAVSLGAKLLTRVFDAETTPIYLSDPTWPNHYGVVKAAGWK 160 Query: 230 QVNYYL--DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 + Y D + +LN +++ + A D + NPTG S++ ++ Sbjct: 161 NICTYAYYDPKTV-SLNFEGMKKDILAAPDGSV--FILHQCAHNPTGVDPSQEQWNEIAS 217 Query: 288 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 347 + + D YQ S Y +E+ S SK MG Sbjct: 218 LMLAKHHQVFFDSAYQGYASG------SLDTDAYAARLFARRGIEVLLAQSFSKN-MGLY 270 Query: 348 GYRGGYMEVI----NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFS 403 R G + ++ ++K + L+ P + A + ++ ++ E +++ Sbjct: 271 SERAGTLSLLLKDKTKRADVKSVMDSLIREEYTCPPAHGARLAHLI---LSNNELRKEWE 327 Query: 404 REKESVLGNLAKKAKLTEDLFNQV 427 E ++ + + D ++ Sbjct: 328 AELSAMAERIRTMRRTVYDELLRL 351 >3II0-A nrPDB Length = 422 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 51/309 (16%), Positives = 97/309 (31%), Gaps = 27/309 (8%) Query: 131 AKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI--YLTTGAS 188 KK ++I N Y G+ R A+ + D + + G + Sbjct: 42 VKKVEQKIANDNSLN--HEYLPILGLAEFR-SCASRLALGDDSPALKEKRVGGVQSLGGT 98 Query: 189 DGIST---ILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVN--YYLDEENCWAL 243 + L +G T V + P + ++AV S + Y D E L Sbjct: 99 GALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKR-GL 157 Query: 244 NVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 ++ ++ A + + NPTG + + + + LF D YQ Sbjct: 158 DLQGFLNDLENAPEFSIV--VLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQ 215 Query: 304 DNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE- 362 R + G E+ S SK G R G + V+ PE Sbjct: 216 GFASGNLERDAWAIRYFVSEGFEFFCA------QSFSKN-FGLYNERVGNLTVVGKEPES 268 Query: 363 ---IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 + Q+ K++ + P + A + ++ E FE+++ +++ + Sbjct: 269 ILQVLSQMEKIVRITWSNPPAQGARIVAST---LSNPELFEEWTGNVKTMADRILTMRSE 325 Query: 420 TEDLFNQVP 428 + Sbjct: 326 LRARLEALK 334 >3P1T-A nrPDB Length = 337 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 69/394 (17%), Positives = 116/394 (29%), Gaps = 81/394 (20%) Query: 122 LDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 L PE A + + A + Y + +A + + + DN+ Sbjct: 21 LAFNENPE-AVEPRVQAAIAAAAARINRY-PFDAEPRVMRKLAEHFSCPE-------DNL 71 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 L G + I S + P + Y A I+ L ++ Sbjct: 72 MLVRGIDECFDRISAEF------SSMRFVTAWPGFDGYRARIAVSGLRHFEIGLTDDLL- 124 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 + + + NP NPTGQ S ++ + A + LL DE Sbjct: 125 --------LDPNDLAQVSRDDCVVLANPSNPTGQALSAGELDQLRQRAGK----LLIDET 172 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 Y D S + E F S SK Y G G R G + Sbjct: 173 YVDY---------SSFRARGLAYGENE-----LVFRSFSKSY-GLAGLRLG---ALFGPS 214 Query: 362 EIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTE 421 E+ + + +D+ A E + + + + LA++ ++ + Sbjct: 215 ELIAAMKRKQWF------CNVGTLDL-----HALEAALDNDRAREAHIAKTLAQRRRVAD 263 Query: 422 DLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG 481 L +G Y VE A + ++ L E GI V Sbjct: 264 AL------------RGLGYRVASSEANFVLVENAAGERT-------LRFLRERGIQVKDA 304 Query: 482 SGFGQREGTYHFRMTILPPV--EKLKTVLQKVKD 513 FG H R++I ++L L + D Sbjct: 305 GQFGLHH---HIRISIGREEDNDRLLAALAEYSD 335 >3K7Y-A nrPDB Length = 405 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 58/181 (32%), Gaps = 12/181 (6%) Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 G + I +L+ L + + + P Y + +I + N Sbjct: 101 IQCIGGTGAIFVLLEFLKML---NVETLYVTNPPYINHVNMIESRGFNLKYINFFDYNLI 157 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 +N + ++ + + NP K +++I +K ++ D Sbjct: 158 DINYDLFLNDLRNIPNGSSVILQISCY--NPCSVNIEEKYFDEIIEIVLHKKHVIIFDIA 215 Query: 302 YQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHP 361 YQ + ++ + + N+ + S SK M G R G + ++ + Sbjct: 216 YQGF------GHTNLEEDVLLIRKFEEKNIAFSVCQSFSKN-MSLYGERAGALHIVCKNQ 268 Query: 362 E 362 E Sbjct: 269 E 269 >3DR4-A nrPDB Length = 391 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 19/147 (12%), Positives = 41/147 (27%), Gaps = 26/147 (17%) Query: 156 VNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKIL-VSGGGKSRTGVMIPIP 214 + + A Y + + + L + + G + V++P Sbjct: 58 IVEFEKAFADYCGVKHA---------IACNNGTTALHLALVAMGIGPGDE----VIVPSL 104 Query: 215 QYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTG 274 Y + ++ A V D + L+ +L + P L G Sbjct: 105 TYIASANSVTYCGATPVLVDNDPRT-FNLDAAKLEALITPRTKAIMPVHLY--------G 155 Query: 275 QVQSRKCIEDVIHFAWEEKLFLLADEV 301 Q+ ++ A L ++ D Sbjct: 156 QICDMD---PILEVARRHNLLVIEDAA 179 >1YAA-A nrPDB Length = 412 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 100/311 (32%), Gaps = 27/311 (8%) Query: 130 DAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI--YLTTGA 187 + K A +++ + Y G+ + + A I D + + Sbjct: 50 PSVKAAEKLIHND-SSYNHEYLGITGLPSLTSNAAKIIFGTQSD-ALQEDRVISVQSLSG 107 Query: 188 SDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNE 247 + + K V + P + + A+ Y +L++N Sbjct: 108 TGALHISAKFFSKFF--PDKLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNG 165 Query: 248 LRRAVQEAKDHCDPKVLCIIN-PGNPTGQVQSRKCIEDVI-HFAWEEKLFLLADEVYQDN 305 A+Q+A + + + + NPTG + + ++ A + + L D YQ Sbjct: 166 FLNAIQKAPEGS---IFVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALF-DTAYQGF 221 Query: 306 VYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI-------- 357 + ++ E S+ + S +K G G R G + Sbjct: 222 ATGDLDKDAYAVRLGVEK---LSTVSPVFVCQSFAKN-AGMYGERVGCFHLALTKQAQNK 277 Query: 358 NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKA 417 + P + QL K++ + P + A + + + E EQ+ ++ ++ + K Sbjct: 278 TIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKL---LETPELTEQWHKDMVTMSSRITKMR 334 Query: 418 KLTEDLFNQVP 428 D ++ Sbjct: 335 HALRDHLVKLG 345 >4W5K-A nrPDB Length = 396 Score = 51.8 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 44/291 (15%), Positives = 87/291 (29%), Gaps = 24/291 (8%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPDNIY--LTTGASDGISTILKILVSGGGKSR 206 Y+ G+ E+ A + I T G + + I L++ + Sbjct: 61 DYAPVTGIASFVEE-AQKLCFGPTCAALRDGRIASCQTLGGTGALR-IGGDLLNRFVANC 118 Query: 207 TGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCI 266 + P YP + ++ ++ Y + LN+ + + +A + +L Sbjct: 119 NRIYGPDVGYPNHESIFAKAGMELTPYSYYDPATKGLNLAGMLECLDKAPEGSV--ILVH 176 Query: 267 INPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 NPTG + V D YQ + L +M Sbjct: 177 ACAHNPTGVDPTHDDWRQVCDVIKRRNHIPFVDMAYQGFATGQLDYDAFVPRHLVDM--- 233 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVS------ 380 V + G G+R G + + E +LV L++ + P S Sbjct: 234 ----VPNLIVAQSFSANFGLYGHRCGALHISTASAEEAKRLVSQLALLIRPMYSNPPLYG 289 Query: 381 GQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIH 431 I+ +P + + +E + + +A+ K +H Sbjct: 290 AWVVSSILKDPQLTAL-----WKKELKQMSSRIAEVRKRLVSELKACGSVH 335 >1TAR-A nrPDB Length = 401 Score = 51.8 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 46/297 (15%), Positives = 93/297 (31%), Gaps = 18/297 (6%) Query: 150 YSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASD-GISTILKILVSGGGKSRTG 208 Y G+ A + + G S G + + K Sbjct: 67 YLPIAGLADFTRASAE-LALGENSEAFKSGRYVTVQGISGTGSLRVGANFLQRFFKFSRD 125 Query: 209 VMIPIPQYPLYSAVISELDA-IQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 V +P P + ++ + + +Q Y D + C +L+ + + + +L Sbjct: 126 VYLPKPSWGNHTPIFRDAGLQLQAYRYYDPKTC-SLDFTGAMEDISKIPEKS--IILLHA 182 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEY 327 NPTG ++ +++ + L D YQ R + E G Sbjct: 183 CAHNPTGVDPRQEQWKELASVVKKRNLLAYFDMAYQGFASGDINRDAWALRHFIEQG--- 239 Query: 328 SSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRL-----CPPVSGQ 382 +++ S +K MG G R G VI E ++ L + + PP++G Sbjct: 240 ---IDVVLSQSYAKN-MGLYGERAGAFTVICRDAEEAKRVESQLKILIRPMYSNPPMNGA 295 Query: 383 AAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAM 439 +++N P +E + + ++ + + + H G Sbjct: 296 RIASLILNTPELRKEWLVEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMF 352 >2C81-A nrPDB Length = 418 Score = 51.8 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 63/175 (36%), Gaps = 20/175 (11%) Query: 125 PSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLT 184 P +P+ + + R+I + N G + A GVP T Sbjct: 9 PEWPQHSDRTRRKIEEVFQSNRWAISGYWTGEESMERKFAKAFAD-FNGVPY----CVPT 63 Query: 185 TGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALN 244 T S + L+ L G V++P + + + ++A+ V ++ + + ++ Sbjct: 64 TSGSTALMLALEAL---GIGEGDEVIVPSLTWIATATAVLNVNALPVFVDVEADT-YCID 119 Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 ++ A+ + K + P S ++++ A E LF++ D Sbjct: 120 PQLIKSAITDKT-----KAII------PVHLFGSMANMDEINEIAQEHNLFVIED 163 >4W91-A nrPDB Length = 422 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 56/407 (13%), Positives = 122/407 (29%), Gaps = 61/407 (14%) Query: 133 KRARRILQACGGNSLGSYSAS-QGVNCIREDVAAYITRRDGGV-----PADPDNIYLTTG 186 ++ + ++ A Y+ +G++ + + V D I T Sbjct: 50 QKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKSRETVRRFLNAGSVDEIVFTKN 109 Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISEL------DAIQVNYYLDEENC 240 A++ I+T+ +++ I + +S ++ A V +D+ Sbjct: 110 ATEAINTVAYGYGMPFIGEGDEILLSIME--HHSNIVPWHFIRERQGAKLVFTPVDDNGV 167 Query: 241 WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 + + E + + E K++ I + N G V I+ ++ A + +L D Sbjct: 168 FHI--EEFEKRLSE-----RTKLVAITHMSNTLGTVVP---IKKIVELAHARGIPVLVDG 217 Query: 301 VYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLH 360 D + ++ Y + + + ++ ++GG + + Sbjct: 218 SQGAVHLPVDVQDLGCDWYVFTGHKVYGPS-GIGVLYGRAQMLEKMRPFQGGGEMIEEVT 276 Query: 361 PEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLT 420 E P QA A E E+ R ++L + A Sbjct: 277 EENVTYNHPPHRFEAGTPPIVQAI------GLGAALEYMEKIGR--HAILAHEADLRDYA 328 Query: 421 EDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVP 480 + ++ + F + A A D+ ++ G+ V Sbjct: 329 HERLGRINSLR---------IFGNAPDKGAIISFALEGIHAHDVSMV---IDRAGVAVRA 376 Query: 481 GS--------GFGQREGTYHFRMTIL-----PPVEKLKTVLQKVKDF 514 G+ FG T R + V+ L L+K + F Sbjct: 377 GTHCAQPLLKRFGV---TSTCRASFALYNTRAEVDALAEALEKARKF 420 >5TON-A nrPDB Length = 414 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 48/304 (15%), Positives = 89/304 (29%), Gaps = 23/304 (7%) Query: 148 GSYSASQGVNCIREDVAAYITRRDGGVPADPDNI--YLTTGASDGISTILKILV---SGG 202 Y G+ R A+ + D + + G + + + L +G Sbjct: 70 HEYLPILGLAEFR-TCASRLALGDDSPALQEKRVGGVQSLGGTGALRIGAEFLARWYNGT 128 Query: 203 GKSRTGVMIPIPQYPLYSAVISELDAIQVN--YYLDEENCWALNVNELRRAVQEAKDHCD 260 T V + P + + V + + Y D E L++ ++ A + Sbjct: 129 NNKDTPVYVSSPTWENLNGVFTTAGFKDIRSYRYWDTEKR-GLDLQGFLSDLENAPEFS- 186 Query: 261 PKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVL 320 + NPTG + + + + LF D YQ + + Sbjct: 187 -IFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGNLEKDAWAIRYF 245 Query: 321 YEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE----IKGQLVKLLSVRLC 376 G E S SK G R G + V+ P+ + Q+ K++ V Sbjct: 246 VSEGFELFCA------QSFSKN-FGLYNERVGNLTVVAKEPDSILRVLSQMQKIVRVTWS 298 Query: 377 PPVSGQAAMDI-VVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPL 435 P + A + ++ P E + +L ++ E L H Sbjct: 299 NPPAQGARIVARTLSDPELFHEWTGNVKTMADRILSMRSELRARLEALKTPGTWNHITDQ 358 Query: 436 QGAM 439 G Sbjct: 359 IGMF 362 >5C6U-A nrPDB Length = 435 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 57/387 (14%), Positives = 108/387 (27%), Gaps = 56/387 (14%) Query: 143 GGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGIST---ILKILV 199 G +Y G+ +R A + N+ +S + +L Sbjct: 61 EGTDTRNYGGQHGLPGLRAIFAELLG-------IAVPNLIAGNNSSLELMHDIVAFSMLY 113 Query: 200 SGGGKSRTGV--------MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRA 251 G R + + P+P Y + A+ + + + ++ +V+ + Sbjct: 114 GGVDSPRPWIQEQDGIKFLCPVPGYDRHFAITETMGIEMIPIPMLQD---GPDVDLIEEL 170 Query: 252 VQEAKDHCDPKVLCIINP--GNPTGQVQSRKCIEDVIHF-AWEEKLFLLADEVYQDNVYS 308 V K + + P GNP+G S + + ++ L D Y V++ Sbjct: 171 VA---VDPAIKGMWTV-PVFGNPSGVTYSWETVRRLVQMRTAAPDFRLFWDNAYA--VHT 224 Query: 309 PDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLV 368 F VL + N F STSK G I L Sbjct: 225 LTLDFPRQVDVLGLAAKAGNPNRPYV-FASTSKITFAGG----GVSFFGGSLGNIAWYLQ 279 Query: 369 KLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVP 428 + P Q R ++ + A A++ + ++ Sbjct: 280 YAGKKSIGPDKVNQLRHLRFFGDADGVRLH---MLRHQQILAPKFALVAEVLDQRLSESK 336 Query: 429 GIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVP-GSGFGQR 487 +G + + A L ++ GI V G+ F R Sbjct: 337 IASWTEPKGGYFISLDVLPGTARRTVA--------------LAKDVGIAVTEAGASFPYR 382 Query: 488 EGTYHFRMTIL---PPVEKLKTVLQKV 511 + + I P V L+ + + Sbjct: 383 KDPDDKNIRIAPSFPSVPDLRNAVDGL 409 >3UWC-A nrPDB Length = 374 Score = 49.1 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 50/137 (36%), Gaps = 19/137 (13%) Query: 165 AYITRRDGGVPADPDNIYLTTGASDGISTILKIL-VSGGGKSRTGVMIPIPQYPLYSAVI 223 +R + P I + TG +D ++ K+L + G + V+ + I Sbjct: 41 EKFEKRFAALHNAPHAIGVGTG-TDALAMSFKMLNIGAGDE----VITCANTFIASVGAI 95 Query: 224 SELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIE 283 + A V D EN + ++ ++ A+ + K + P + TG + Sbjct: 96 VQAGATPVLV--DSENGYVIDPEKIEAAITDKT-----KAIM---PVHYTGNIADMP--- 142 Query: 284 DVIHFAWEEKLFLLADE 300 + A + L ++ D Sbjct: 143 ALAKIAKKHNLHIVEDA 159 >4EFF-A nrPDB Length = 420 Score = 48.7 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 38/285 (13%), Positives = 80/285 (28%), Gaps = 31/285 (10%) Query: 149 SYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTT--GASDGIS--TILKILVSGGGK 204 Y G+ V + D + + G + + ++ Sbjct: 87 GYLPIDGIAAYDASVQKLLLGDDSPL-IAAGRVVTAQALGGTGALKIGADFLRTLNP--- 142 Query: 205 SRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVL 264 + V I P + + A+ V Y + +N + + A+ + + Sbjct: 143 -KAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVNFDGMLAALNGYEPGTIVVLH 201 Query: 265 CIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMG 324 NPTG + V+ +L D YQ S + + Sbjct: 202 ACC--HNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGF-------GESIEADAAAVR 252 Query: 325 PEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE----IKGQLVKLLSVRLCPPVS 380 ++N+ + S SK G R G + +I + + QL +++ P + Sbjct: 253 LFAAANLNVFVSSSFSKS-FSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPT 311 Query: 381 GQAAMDIVVNPPVAGE--------ESFEQFSREKESVLGNLAKKA 417 A+ V E ++ + ++ L Sbjct: 312 HGGAIVAAVLASPELRASWVQELGEMRDRIRAMRNGLVERLKAAG 356 >3VK2-A nrPDB Length = 398 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 53/178 (29%), Gaps = 26/178 (14%) Query: 126 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTT 185 +FP A + G + + + R A + + G+ Sbjct: 39 TFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEAR---MASLEGGEAGLALAS------- 88 Query: 186 GASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNV 245 I++ L L+ G + V++ Y A + + + + ++ Sbjct: 89 -GMGAITSTLWTLLRPGDE----VLLGNTLYGHTFAFLHHGIG---EFGVKLRHVDMADL 140 Query: 246 NELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 L A+ A +V+ +P NP I V A + ++ D Y Sbjct: 141 QALEAAMTPAT-----RVIYFESPANP---NMHMADIAGVAKIARKHGATVVVDNTYC 190 >4OBV-D nrPDB Length = 490 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 86/248 (34%), Gaps = 21/248 (8%) Query: 67 PIVLKAGEIELELQRGIKKPFTEVIRANIGDAQ-AMGQQPITFLRQVMALCTYPNLLDSP 125 P+V++A E + + + IK P G + + + + + +P Sbjct: 47 PVVVEAKEHQEDKIKQIKIPEK-------GRPVNEVVSEMMNEVYRYRGDANHPRFFSFV 99 Query: 126 SFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTT 185 P + I+ + G + VNCI ++V ++ ++ G +P ++++ Sbjct: 100 PGPASSVSWLGDIMTSAYNIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTE-NPGGVFVS- 157 Query: 186 GASDGISTILKILVSGGGKSRTGVMIPIPQYPL---YSAVISELDAIQVN----YYLDEE 238 G S T L K + Y +S+V L I + + Sbjct: 158 GGSMANITALTAARD--NKLTDINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIPTN 215 Query: 239 NCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLA 298 + + ++ +L A++ K + I G T S + ++ + ++ Sbjct: 216 SHFQMDTTKLEEAIETDKKSGYIPFVVIGTAG--TTNTGSIDPLTEISALCKKHDMWFHI 273 Query: 299 DEVYQDNV 306 D Y +V Sbjct: 274 DGAYGASV 281 >1M6S-A nrPDB Length = 347 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 26/180 (14%), Positives = 64/180 (35%), Gaps = 17/180 (9%) Query: 122 LDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNI 181 L S + + ++ + + QA G+ + Y +N + A + + Sbjct: 8 LRSDTVTKPTEEMRKAMAQAEVGDDV--YGEDPTINELERLAAETFGK---------EAA 56 Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 + G + G + V++ + + V + V + Sbjct: 57 LFVPSGTMGNQVSIMAHTQRGDE----VILEADSHIFWYEVGAMAVLSGVMPHPVPGKNG 112 Query: 242 ALNVNELRRAVQEAKDH-CDPKVLCIINPGN-PTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 A++ +++R+A++ H ++ I N N G+V + I+++ A E + + D Sbjct: 113 AMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEHGINVHID 172 >2HOR-A nrPDB Length = 427 Score = 45.7 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 46/339 (13%), Positives = 99/339 (29%), Gaps = 50/339 (14%) Query: 181 IYLTTGASDGISTILKIL-----VSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYL 235 I G + I ++ L + + V+ P YP++ D + Sbjct: 126 IVFGVGVTQLIHGLVISLSPNMTATP-DAPESKVVAHAPFYPVFREQTKYFDKKGYVWAG 184 Query: 236 DEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLF 295 + N +NV+ + ++ + +P NP G ++ A + Sbjct: 185 NAANY--VNVSNPEQYIE-----------MVTSPNNPEG----------LLRHAVIKGCK 221 Query: 296 LLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYME 355 + D VY Y+P +L+ M + G G R G+ Sbjct: 222 SIYDMVYYWPHYTPIKYKADEDILLFTMS-----------------KFTGHSGSRFGWAL 264 Query: 356 VINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAK 415 + + + P + ++ ++ + L + Sbjct: 265 IKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEVVAMVKTQKGTMRDLNTFGFKKLRE 324 Query: 416 KAKLTEDLFNQVPGIHCNPLQGAMYA-FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 474 + L +Q L + Y + R P A + D C + + Sbjct: 325 RWVNITALLDQSDRFSYQELPQSEYCNYFRRMRPPSPSYAWVKCEWEEDKD-CYQTFQNG 383 Query: 475 GICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 I G GF + + R++++ + ++ +KD Sbjct: 384 RINTQNGVGF--EASSRYVRLSLIKTQDDFDQLMYYLKD 420 >2OGE-A nrPDB Length = 399 Score = 45.3 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 38/121 (31%), Gaps = 12/121 (9%) Query: 184 TTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWAL 243 G + G+ + L G V++P Y +S A V E++ L Sbjct: 81 AVGVNSGMDALQLALRGLGIGPGDEVIVPSHTYIASWLAVSATGATPVPVEPHEDHP-TL 139 Query: 244 NVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ 303 + + +A+ P L G+P ++ + A L ++ D Sbjct: 140 DPLLVEKAITPRTRALLPVHLY----GHP-------ADMDALRELADRHGLHIVEDAAQA 188 Query: 304 D 304 Sbjct: 189 H 189 >2E7J-A nrPDB Length = 371 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 53/338 (15%), Positives = 102/338 (30%), Gaps = 43/338 (12%) Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 +T GA + ++ L K VM Y Y A + +A Sbjct: 74 VTNGAREAKFAVMHSLAK---KDAWVVMDENCHYSSYVAAERA-GLNIALVPKTDYPDYA 129 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 + + ++E K + + I P G + ++ + E + LL + Y Sbjct: 130 ITPENFAQTIEETKKRGEVVLALITYPD---GNYGNLPDVKKIAKVCSEYDVPLLVNGAY 186 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 L E+G ++ + S G G G E Sbjct: 187 A---------IGRMPVSLKEIGADF-----IVGSGHKSMAASGPIGV-MGMKEEWAEIVL 231 Query: 363 IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 + + K V L + A + ++ E +++ E E A+ KL Sbjct: 232 RRSEKYKNKEVELLGCTARGATIITLMASFPHVRERIKRWDEEVEKARRFAAEMEKLGIK 291 Query: 423 LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGS 482 P H F + + + A+ + F+ + L+ I Sbjct: 292 QLGDNPHNHDL-------MFFHAEVLYEISKKAKGGR-----FFLYRELKSRKIH----- 334 Query: 483 GFGQREG-TYHFRMT-ILPPVEKLKTVLQKVKDFHINF 518 G + G T +F+++ E++ VL K+ + Sbjct: 335 --GIKPGLTRYFKLSTYGLSDEEVDYVLNAFKEIIEKY 370 >1O69-A nrPDB Length = 394 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 48/125 (38%), Gaps = 13/125 (10%) Query: 177 DPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLD 236 +N A+ + L++ G K V+ + A I L A V D Sbjct: 46 KSENALALNSATAALHLALRV---AGVKQDDIVLASSFTFIASVAPICYLKAKPVFIDCD 102 Query: 237 EENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFL 296 E + ++V+ L+ A++E + PK L + T + +++++ E + L Sbjct: 103 E--TYNIDVDLLKLAIKECEKK--PKALIL------THLYGNAAKMDEIVEICKENDIVL 152 Query: 297 LADEV 301 + D Sbjct: 153 IEDAA 157 >4L0O-H nrPDB Length = 388 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 28/171 (16%), Positives = 56/171 (32%), Gaps = 23/171 (13%) Query: 140 QACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILV 199 A G + YS S G R + I +GGV +G + + L+ Sbjct: 34 DAIGRHKGYEYSRS-GNP-TRFALEELIADLEGGVKGFA----FASGLAGI--HAVFSLL 85 Query: 200 SGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHC 259 G V++ +Y + + V L +++++++A++ Sbjct: 86 QSGDH----VLLGD---DVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKP----- 133 Query: 260 DPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPD 310 + K L + P NP + + A + L + D + Y Sbjct: 134 NTKALYLETPSNP---LLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNP 181 >5W70-A nrPDB Length = 445 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 21/150 (14%), Positives = 53/150 (35%), Gaps = 22/150 (14%) Query: 151 SASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVM 210 +G A +G P A+ G ++++ L + G + V+ Sbjct: 66 GPYRGTESYERRFARAFAAYNGVPHCVP--------AASGTASLMLALEACGIGAGDEVI 117 Query: 211 IPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPG 270 +P + + I ++A+ + +D + L+ + A+ E + + +++ Sbjct: 118 VPGLSWVASGSTILGVNAVPIFCDVDPDT-LCLSPEAVEAAITE-----HTRAIVVVH-- 169 Query: 271 NPTGQVQSR-KCIEDVIHFAWEEKLFLLAD 299 + S ++ + A L L+ D Sbjct: 170 -----LYSALADMDALSAIAERHGLPLIED 194 >5WGB-A nrPDB Length = 426 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 61/165 (36%), Gaps = 20/165 (12%) Query: 141 ACGGNSLGSYSAS--QGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKIL 198 + +Y + R+ VA+ I ADP I T+GA++ + +K + Sbjct: 55 GNPHSRTHAYGWESEAAMERARQQVASLIG-------ADPREIIFTSGATESNNIAIKGV 107 Query: 199 VSGGGKSRTGVMIPIPQYPLYSAVIS--ELDAIQVNYYLDEENCWALNVNELRRAVQEAK 256 + ++ ++ E + QV Y +++ +++ EL A+Q Sbjct: 108 ARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGI-IDLKELEAAIQP-- 164 Query: 257 DHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 D ++ ++ N G ++ I ++ K++ D Sbjct: 165 ---DTSLVSVMTVNNEIGV---KQPIAEIGRICSSRKVYFHTDAA 203 >3AEO-A nrPDB Length = 389 Score = 43.0 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 40/291 (13%), Positives = 80/291 (27%), Gaps = 46/291 (15%) Query: 189 DGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNEL 248 IS+ + G G LY +S + ++ + +V ++ Sbjct: 85 GAISSSTLAFLQKGDHLIAGD-------TLYGCTVSLFTHWLPRFGIEVDLIDTSDVEKV 137 Query: 249 RRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYS 308 + A + + K++ + +P NPT +V I+ + E L+ D Sbjct: 138 KAAWKP-----NTKMVYLESPANPTCKV---SDIKGIAVVCHERGARLVVD--------- 180 Query: 309 PDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLV 368 +F + E +++ L S G+ G G + Sbjct: 181 -----ATFTSPCFLKPLELGADIALHSVSKYINGHGDVIG---GVSSAKTAEDIATIKFY 232 Query: 369 KLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVP 428 + + L P+ + P+ + E + L K K+ P Sbjct: 233 RKDAGSLMAPMDAFLCARGMKTLPIRMQIHMENGLK-VAKFLEQHEKIVKVNHPGLESFP 291 Query: 429 GIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVV 479 G I + KL+E +C + Sbjct: 292 G-------------HDIAKKQMTGYGSTFLFEMKSFEAAKKLMEHLKVCTL 329 >1CS1-A nrPDB Length = 386 Score = 43.0 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 51/152 (33%), Gaps = 22/152 (14%) Query: 148 GSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRT 207 YS +G R+ V + +GG A LT I + + + G Sbjct: 44 HDYS-RRGNP-TRDVVQRALAELEGGAGA-----VLTNTGMSAIHLVTTVFLKPGD---- 92 Query: 208 GVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCII 267 ++ P + Y D++ + LR A+ E PK++ + Sbjct: 93 --LLVAP-HDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEK-----PKLVLVE 144 Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 +P NP +V I + H A E + D Sbjct: 145 SPSNPLLRVVD---IAKICHLAREVGAVSVVD 173 >6C9E-A nrPDB Length = 422 Score = 41.8 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 59/399 (14%), Positives = 118/399 (29%), Gaps = 44/399 (11%) Query: 128 PEDAKKRARRILQACGGN-SLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTG 186 P+ + + N G ++ S + E A + R P G Sbjct: 52 PKAVIDAIAQFYEKDNSNVHRGVHALSVRATEMYEAARAKVKRFINAR--SPRECIFVRG 109 Query: 187 ASDGISTILKILVSGGGKSRTGVMIP----IPQYPLYSAVISELDAIQVNYYLDEENCWA 242 ++ I+ + + LV+ ++I + V ++ + Sbjct: 110 TTEAINLVAQSLVAPRILPDEEILITHMEHHSNIVPWQMVCKKMGCKLQVAPI--SLNGE 167 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD--E 300 + + E R + E + K++ I N G + ++ +I A E +L D + Sbjct: 168 VILEEFERKLNE-----NTKMVAINYASNSLGTINP---VKTMIKMAHEVGAKVLLDGAQ 219 Query: 301 VYQDNVYSP---DCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI 357 + DC F++F G + + + Y+GG + Sbjct: 220 ATAHLIVDVQDLDCDFYAFS------GHKMYGPTGIGVLWGKEELLNSMTPYQGGGEMIN 273 Query: 358 NLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKA 417 ++ E P A + + E E+ L N A KA Sbjct: 274 SVSFEATEYAAIPHKFEAGTPNIAGAIGLAAAIDYIWSLDL--DAIAEYETQLLNYATKA 331 Query: 418 KLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGIC 477 +N + G N ++ I + AH + + + C Sbjct: 332 IEAVKGYN-IIGTAAN----------KVPIISFVHGKIHAHDIGTILDSEGIAIRSGHHC 380 Query: 478 VVPGSGFGQREGTYHFRMTILPPVEKLK---TVLQKVKD 513 +P F T M+ +++ LQ+VK+ Sbjct: 381 TMPLMDFYDVAATSRISMSFYNTFKEIDYCMEALQRVKE 419 >3LVM-A nrPDB Length = 423 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 51/129 (39%), Gaps = 11/129 (8%) Query: 174 VPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISEL--DAIQV 231 V ADP I T+GA++ + +K + K ++ ++ +L + +V Sbjct: 81 VGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEV 140 Query: 232 NYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWE 291 Y + N +++ EL A+++ D ++ I++ N G V + I + Sbjct: 141 TYLAPQRNGI-IDLKELEAAMRD-----DTILVSIMHVNNEIGVV---QDIAAIGEMCRA 191 Query: 292 EKLFLLADE 300 + D Sbjct: 192 RGIIYHVDA 200 >4PIW-A nrPDB Length = 396 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 46/148 (31%), Gaps = 22/148 (14%) Query: 155 GVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKIL-VSGGGKSRTGVMIPI 213 G ++ +R G + LT + + +L + G + V++P Sbjct: 48 GDGGFTRRCQQWLEQRFGSAK-----VLLTPSCTASLEMAALLLDIQPGDE----VIMPS 98 Query: 214 PQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPT 273 + + A V + + ++ + A+ + +I P + Sbjct: 99 YTFVSTANAFVLRGAKIVFVDVRPDT-MNIDETLIEAAITDKTR--------VIVPVHYA 149 Query: 274 GQVQSRKCIEDVIHFAWEEKLFLLADEV 301 G ++ A + LF++ D Sbjct: 150 GVACEMDT---IMALAKKHNLFVVEDAA 174 >5K8B-A nrPDB Length = 403 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 15/114 (13%), Positives = 36/114 (31%), Gaps = 16/114 (14%) Query: 187 ASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVN 246 + + T + G + V++P + +V + A V + + + L+ Sbjct: 61 GTAALQTAMMA---AGIGAGDEVIVPPFTFVA--SVEAIFMAGAVPIFAEIDETLCLSPE 115 Query: 247 ELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADE 300 + + + +C G + I+ + + L LL D Sbjct: 116 GIEAVITPRTKAINLVHMC--------GSMAKMDEIKAI---CKKHNLVLLEDA 158 >2BWN-A nrPDB Length = 401 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 49/321 (15%), Positives = 92/321 (28%), Gaps = 50/321 (15%) Query: 192 STILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQ-VNYYLDEENCWALNVNELRR 250 + + + + + + + P +YS ++ I+ + + + N R Sbjct: 109 ALVFSSAYNANDATLSTLRVLFPGLIIYSDSLNHASMIEGIKRNAGPKRIFRHNDVAHLR 168 Query: 251 AVQEAKDHCDPKVLCIINPGNPTGQVQSRK----CIEDVIHFAWEEKLFLLADEVYQDNV 306 + A D PK++ + V S I+++ A E DEV+ + Sbjct: 169 ELIAADDPAAPKLIAFES-------VYSMDGDFGPIKEICDIAEEFGALTYIDEVHAVGM 221 Query: 307 YSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQ 366 Y P + + L ++ + +K Y GY I + Sbjct: 222 YGPRGAGVAERDGLMHRIDIFN--------GTLAKAYGVFGGY-------IAASARMVDA 266 Query: 367 LVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQ 426 + + A + + Q R+ + + + K + Sbjct: 267 VRSYAPGFIFSTSLPPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLKALGMPII 326 Query: 427 VPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQ 486 G H P + + DM LL + G+ V P F Sbjct: 327 DHGSHIVP---------------VVIGDPVHTKAVSDM-----LLSDYGVYVQP-INFPT 365 Query: 487 RE-GTYHFRMTILPPVEKLKT 506 GT R T PV LK Sbjct: 366 VPRGTERLRFT-PSPVHDLKQ 385 >6CJB-A nrPDB Length = 391 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 18/55 (32%), Gaps = 8/55 (14%) Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 + A+ K+L + P NP + + A + L +AD Sbjct: 136 PENIEAAITPKT-----KLLWLETPSNPM---LKLANLRKIAAIAKKYNLITVAD 182 >4E3Q-A nrPDB Length = 473 Score = 38.3 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 43/339 (12%), Positives = 99/339 (29%), Gaps = 50/339 (14%) Query: 175 PADPDNIYLTTGASDGISTILKIL----VSGGGKSRTGVMIPIPQYPLYSAVISELDAIQ 230 P D ++ T S+ T++K+L + G + ++ Y +AV + + Sbjct: 125 PFDSGRVFYTNSGSEANDTMVKMLWFLHAAEGKPQKRKILTRWNAYHGVTAVSASMTGKP 184 Query: 231 VN----------YYLDEENCWALNVN-------------ELRRAVQEAKDHCDPKVLCII 267 N +L + W EL +Q ++ D Sbjct: 185 YNSVFGLPLPGFVHLTCPHYWRYGEEGETEEQFVARLARELEETIQ--REGADTIAGFFA 242 Query: 268 NPGNPTGQVQSRK--CIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGP 325 P G V + ++ + + +++DEV +++ V Y+ P Sbjct: 243 EPVMGAGGVIPPAKGYFQAILPILRKYDIPVISDEVICGF----GRTGNTWGCVTYDFTP 298 Query: 326 EYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAM 385 + + S + + G+ G E+ + + A+ Sbjct: 299 D-----AIISSKNLTAGFFPMGAVILGP-ELSKRLETAIEAIEEFPHGFTASGHPVGCAI 352 Query: 386 DIVVNPPVAGEESFEQFSR---EKESVLGNLAKKAKLTE-DLFNQVPGIHCNPLQGAMYA 441 + V E E R E L ++A++ + E + + + Sbjct: 353 ALKAIDVVMNEGLAENVRRLAPRFEERLKHIAERPNIGEYRGIGFMWALEAVKDKA---- 408 Query: 442 FPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVP 480 + + + D+ + L ++ + P Sbjct: 409 -SKTPFDGNLSVSERIANTCTDLGLICRPLGQSVVLCPP 446 >5IJG-A nrPDB Length = 427 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 60/191 (31%), Gaps = 25/191 (13%) Query: 119 PNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIR------EDVAAYITRRDG 172 P + + +F + R G G+ R E V + +G Sbjct: 38 PPVFLTSTFVFKTAEDGRDFFDFVSGRKEPPAGVGAGLVYSRFNHPNSEIVEDRLAVYEG 97 Query: 173 GVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVIS---ELDAI 229 A ++G S I+T L V G ++ P Y +++ + Sbjct: 98 AESAA----LFSSGMS-AIATTLFAFVRPGD----VILHSQPLYGGTETLLAKTFFNFGV 148 Query: 230 QVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHF- 288 + + D + + +A +EA V+ I P NPT + + V Sbjct: 149 EAVAFADGVHE-----ATIEKAAEEALAKGRVSVILIETPANPTNSIVDVAAVRRVAEKI 203 Query: 289 -AWEEKLFLLA 298 A + ++A Sbjct: 204 EARQGSRPVIA 214 >5VPR-A nrPDB Length = 414 Score = 37.6 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 50/404 (12%), Positives = 112/404 (27%), Gaps = 56/404 (13%) Query: 133 KRARRILQACGGNSLGSYSAS--QGVNCIREDVAAYITRRDGGVP--ADPD---NIYLTT 185 ++ + +L A N Y+A+ +G++ + + + V + + T Sbjct: 41 QKPKMVLDAI-NNYYEHYNANVHRGIHTLSQVATEMMEDARKKVQRFINAKHDYEVLFTK 99 Query: 186 GASDGIST---ILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 G ++GI+ + L+ + + + + A ++E+ Sbjct: 100 GTTEGINLVAYAMTDLIKKDDEIIISYLEHHSNIVPWQMLCQRTGAKLRVIPMNEDGTLQ 159 Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVY 302 ++V L + E K++ + N G V I + + F+ D Sbjct: 160 IDV--LDEWLSEKT-----KLVSVNQVSNALGIVNPIDEI--IRKVRAKSNAFIFIDGAQ 210 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPE 362 + D + + Y + + + GG + + E Sbjct: 211 AAPHFEIDVQTMDCDFFAFSGHKMYGPT-GTGILYGKASVLEQLNPFHGGGEMIDHCTFE 269 Query: 363 IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 L R A + E+ E L A++ L Sbjct: 270 KTTYA--GLPFRFEAGTPNIAGNIAIGTAVDFMEKVGRSNIAAHEHALLEYAQRKLL--- 324 Query: 423 LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPG- 481 ++ G+ + +A D+ +L++ GI V G Sbjct: 325 ---EIEGLKVYG--------EKANRAGVVSFNLSGIGIASDVGM---ILDKLGIAVRTGH 370 Query: 482 -------SGFGQREGTYHFRMTIL-----PPVEKLKTVLQKVKD 513 FG R + ++ L ++K + Sbjct: 371 HCTQPIMEYFGV---AGTVRASFAVYNTFEEIDILTEGVKKAQK 411 >3I5T-A nrPDB Length = 476 Score = 37.6 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 62/451 (13%), Positives = 128/451 (28%), Gaps = 85/451 (18%) Query: 59 AVEYAVRGPIVLKAGEIELELQRGIK-KPFTEVIRANIGDAQAMGQQPITFLRQVMALCT 117 AV A+R I+L A E+ + E I + D + + P + Sbjct: 13 AVGAAMRDHILLPAQEMAKLGKSAQPVLTHAEGIYVHTEDGRRLIDGPAGMWCAQVGYGR 72 Query: 118 YPNLLDSPSFPEDAKKRARRILQACGGNSLG-SYSAS---QGVNCIREDVAAYITRRDGG 173 R I+ A ++ Y++ R +A I Sbjct: 73 ------------------REIVDAMAHQAMVLPYASPWYMATSPAAR--LAEKIA---TL 109 Query: 174 VPADPDNIYLTTGASDGISTILKIL----VSGGGKSRTGVMIPIPQYPLYSAVISELDAI 229 P D + I+ TTG S + + L+ G + +++ Y +A+ + Sbjct: 110 TPGDLNRIFFTTGGSTAVDSALRFSEFYNNVLGRPQKKRIIVRYDGYHGSTALTAACTGR 169 Query: 230 -------------------QVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVL--CIIN 268 + + A +++L + ++ + P + + Sbjct: 170 TGNWPNFDIAQDRISFLSSPNPRHAGNRSQEAF-LDDLVQEFEDRIESLGPDTIAAFLAE 228 Query: 269 PGNPTGQVQ--SRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPE 326 P +G V + + ++DEV C + ++ + P+ Sbjct: 229 PILASGGVIIPPAGYHARFKAICEKHDILYISDEVVTGF---GRCGEWFASEKVFGVVPD 285 Query: 327 YSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMD 386 + +F G G + I G+ K S Q Sbjct: 286 ------IITFAKGVTSGYVPLG---GLAISEAVLARISGENAKGSWFTNGYTYSNQ---P 333 Query: 387 IVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDL---FNQVPGIHCNPLQGAMYAFP 443 + +A E E+E ++ + A +PG+ G Sbjct: 334 VACAAALANIELM-----EREGIVDQAREMADYFAAALASLRDLPGVAETRSVG------ 382 Query: 444 RIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 474 + ++ +A A D + +K+ E Sbjct: 383 LVGCVQCLLDPTRADGTAEDKAFTLKIDERC 413 >4IYO-A nrPDB Length = 397 Score = 37.2 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 20/143 (13%), Positives = 38/143 (26%), Gaps = 25/143 (17%) Query: 167 ITRRDGGVPADPDNIYLT-TGASDGISTI--------LKILVSGGGKSRTGVMIPIPQYP 217 +R + G + + + L+ G V + Sbjct: 58 YSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLDAGSHV---VAMDD---- 110 Query: 218 LYSAVISELDAIQVNY-YLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQV 276 LY + ++ LD + + A+ D K++ I P NP Sbjct: 111 LYGGTFRLFERVRRRTAGLDFSFVDLTDPAAFKAAI-----RADTKMVWIETPTNPM--- 162 Query: 277 QSRKCIEDVIHFAWEEKLFLLAD 299 I + A + L + D Sbjct: 163 LKLVDIAAIAVIARKHGLLTVVD 185 >5JAY-A nrPDB Length = 402 Score = 36.4 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 28/182 (15%), Positives = 51/182 (28%), Gaps = 36/182 (19%) Query: 243 LNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRK----CIEDVIHFAWEEKLFLLA 298 + + L ++ D KV+ + V S + ++ A + +L+ Sbjct: 165 CDTDALSAMLEA--SDADVKVIV-------SDTVFSMDGDIAPLPRLLELAEQHGAWLIV 215 Query: 299 DEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVIN 358 D+ + V P R + L L S + K G G + Sbjct: 216 DDAHGFGVLGPQGRGAIAQAALRSPN--------LISIGTLDKA-AGVSG------AFVA 260 Query: 359 LHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVN--------PPVAGEESFEQFSREKESVL 410 H + LV+ + S AA V A +Q ++L Sbjct: 261 AHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIGRTRAML 320 Query: 411 GN 412 Sbjct: 321 KA 322 >5KR3-A nrPDB Length = 479 Score = 36.0 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 82/280 (29%), Gaps = 39/280 (13%) Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKC--IEDVIHFAWEEKLFLLADEVY 302 V EL + + A++ D I P TG + E + + + L+ADEV Sbjct: 225 VEELEKLI--AREGADTIAAFIAEPVMGTGGIIPPPQGYWEAIQAVLRKHDILLIADEV- 281 Query: 303 QDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGG---YMEVINL 359 C F + ++ + + Y G G + + Sbjct: 282 -------VCGFGRLGSKMGSQHYGIKPDLITVAK-GLTSAYAPLSGVIVGEKVWDVIEKG 333 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 E + P+ AA+ + E+E++ GN A Sbjct: 334 SQE--HGPMGHGWTYSGHPICAAAALANLD-------------ILERENLTGNAADVGAY 378 Query: 420 TEDLFNQVPGIHCNPLQ----GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETG 475 + ++ G H + G + A + A ++ P + LE+ Sbjct: 379 LQQRLHEAFGAHPLVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAAA--LEDGM 436 Query: 476 I--CVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 I + G G R + V K + +V D Sbjct: 437 IARAMPHGDILGFAPPLVTTRAEVDEIVGIAKQAVDEVAD 476 >4BMK-A nrPDB Length = 442 Score = 34.9 bits (78), Expect = 0.081, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 43/139 (30%), Gaps = 12/139 (8%) Query: 282 IEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSK 341 +++++ A + +L DE + + P+ R +YE + S S Sbjct: 235 LKEMVAVAKKHGAMVLVDEAHSMGFFGPNGR------GVYEAQGLEGQIDFVVGTFSASV 288 Query: 342 GYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQ 401 G +G G++ + E + P S A + + E E+ Sbjct: 289 GTVG------GFVVSNHPKFEAVRLACRPYIFTASLPPSVVATATTSIRKLMTAHEKRER 342 Query: 402 FSREKESVLGNLAKKAKLT 420 ++ G L Sbjct: 343 LWSNARALHGGLKAMGFRL 361 >3NDN-A nrPDB Length = 414 Score = 34.9 bits (78), Expect = 0.084, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 35/122 (28%), Gaps = 15/122 (12%) Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 + T + T L L+ G + + + + S ++ V D+ + W Sbjct: 100 FATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQW 159 Query: 242 ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 E + + P NP + I V A ++ D V Sbjct: 160 ------------ERALSVPTQAVFFETPSNPMQSLVD---IAAVTELAHAAGAKVVLDNV 204 Query: 302 YQ 303 + Sbjct: 205 FA 206 >3A9Z-A nrPDB Length = 432 Score = 34.9 bits (78), Expect = 0.094, Method: Composition-based stats. Identities = 53/340 (15%), Positives = 112/340 (32%), Gaps = 53/340 (15%) Query: 124 SPSFPEDAKKRARRILQACGGNSLGSYSASQG----VNCIREDVAAYITRRDGGVPADPD 179 +P PE + ++ GN SY A + +N R +A I + P Sbjct: 28 TPLEPE-VIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGK-------PQ 79 Query: 180 NIYLTTGASDGISTILKILVSGGGKSRT----GVMIPIP---QYPLYSAVISELDAI--- 229 +I T+G ++ + ++ V + +T V P P + E D+I Sbjct: 80 DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLP 139 Query: 230 ----------QVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQS- 278 +V + + + V ++ AV+ ++ I+ N TG + Sbjct: 140 LEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTC-----LVTIMLANNETGVIMPI 194 Query: 279 ---RKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 + I+ + L + V++ + ++V E + Sbjct: 195 SEISRRIKALNQIRAASGLPRV-------LVHTDAAQALGKRRVDVEDLGVDFLTIVGHK 247 Query: 336 FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG 395 F+ G + G G ++ L+P + G + A + + Sbjct: 248 FYGPRIGALYVRG--VG--KLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSEN 303 Query: 396 EESFEQFSRE-KESVLGNLAKKAKLTEDLFNQVPGIHCNP 434 E++E R+ ++ + L + L ++ PG+ P Sbjct: 304 CETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLP 343 >4GSA-A nrPDB Length = 432 Score = 34.5 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 56/407 (13%), Positives = 109/407 (26%), Gaps = 66/407 (16%) Query: 107 TFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGG-NSLGSYSAS---QGVNCIRED 162 + +R ++ P + D K + + +G++ + + E Sbjct: 28 SPVRAFKSVGGQPIVFDR------VKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEA 81 Query: 163 VAAYITR-RDGGVPADPDNIY--LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLY 219 + + + G P +N+ + A I + V+ G ++ V+ + Y Sbjct: 82 LKVAMEKGTSFGAPCALENVLAEMVNDAVPSIE--MVRFVNSGTEACMAVLRLMRAYTGR 139 Query: 220 SAVISELD-------------AIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCI 266 +I V + D K L Sbjct: 140 DKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFA 199 Query: 267 INPGNPTGQVQ------------SRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFH 314 NPG G + +E + E L+ DEV Sbjct: 200 ENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEV------------M 247 Query: 315 SFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVR 374 + ++ Y E + G G GG E++ L + Sbjct: 248 TGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAP--AGPMYQAGTL 305 Query: 375 LCPPVSGQAAMDIVVNPPVAG-EESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCN 433 P++ A + + G E +Q ++ L +A+ + C Sbjct: 306 SGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQ----------ETGHAACG 355 Query: 434 PLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVP 480 M+ F P E A+ + + +L E GI + P Sbjct: 356 GQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGML-EQGIYLAP 401 >3N5M-A nrPDB Length = 452 Score = 34.1 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 18/161 (11%), Positives = 44/161 (27%), Gaps = 22/161 (13%) Query: 276 VQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 + + ++ V + L++DEV +F + Y++ P+ + Sbjct: 232 MAPQDYMKAVHETCQKHGALLISDEVICGF----GRTGKAFGFMNYDVKPD-----IITM 282 Query: 336 FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAG 395 + Y+ + + EI ++ + Sbjct: 283 AKGITSAYL--------PLSATAVKREIYEAFKGKGEYEFFRHINTFGGNPAACALALKN 334 Query: 396 EESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQ 436 E E E+++ A+ L + + G H Sbjct: 335 LEIIEN-----ENLIERSAQMGSLLLEQLKEEIGEHPLVGD 370 >4OC9-A nrPDB Length = 424 Score = 34.1 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 39/110 (35%), Gaps = 12/110 (10%) Query: 190 GISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELR 249 G++ L++ S V Y +IS N+ ++ +++ L Sbjct: 84 GMAACFYALINL-ASSGDNVAYSNKIYGGTQTLISH---TLKNFGIEAREFDIDDLDSLE 139 Query: 250 RAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLAD 299 + + + + K + + NP + IE + A + K+ + D Sbjct: 140 KVIDQ-----NTKAIFFESLSNPQIAIAD---IEKINQIAKKHKIVSICD 181 >1IBJ-A nrPDB Length = 464 Score = 33.7 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 34/224 (15%), Positives = 68/224 (30%), Gaps = 27/224 (12%) Query: 254 EAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRF 313 A K++ + +P NP Q+ I + A + +L D Sbjct: 211 AAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD-------------- 253 Query: 314 HSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSV 373 +S + E +++ HS +K G G + V + ++ Sbjct: 254 NSIMSPVLSRPLELGADI---VMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEG 310 Query: 374 RLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPG--IH 431 P + + + E+ E R+ L + + K+ PG +H Sbjct: 311 SGLAPFDCWLCLRGIKTMALRIEKQQENA-RKIAMYLSSHPRVKKVYYAGLPDHPGHHLH 369 Query: 432 CNPLQGAMYAFP----RIFIPAKAVEAAQAHQMAPDMFYCMKLL 471 + +GA F + + VE + +A L+ Sbjct: 370 FSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLI 413 >1WA5-C nrPDB Length = 960 Score = 33.7 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 17/34 (50%) Query: 268 NPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEV 301 NP NP + + I ++++ + L LL D + Sbjct: 609 NPSNPRFTHYTFESIGAILNYTQRQNLPLLVDSM 642 >4EB7-A nrPDB Length = 382 Score = 33.7 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 28/163 (17%), Positives = 59/163 (36%), Gaps = 15/163 (9%) Query: 129 EDAKKRARRILQACGGN--SLGSYS--ASQGVNCIREDVAAYITRRDGGVPADPDNIYLT 184 E + + GN S+ SY A + V RE VA + G + T Sbjct: 14 ERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGG-------TVVFT 66 Query: 185 TGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALN 244 +GA++ + + + +++ + +VI+ +Q + E Sbjct: 67 SGATEANNLAIIGYAMRNARKGKHILVSA---VEHMSVINPAKFLQ-KQGFEVEYIPVGK 122 Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 287 E+ + + K D ++ + + N G +Q + I +V+ Sbjct: 123 YGEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVLA 165 >5I92-A nrPDB Length = 435 Score = 33.3 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 42/320 (13%), Positives = 95/320 (29%), Gaps = 42/320 (13%) Query: 179 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVI---SELDAIQVNYYL 235 + + + + ++ + ++ ++ G R ++ Y +S + + A+ Sbjct: 115 EMVRMVSSGTEATMSAIR--LARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTFGVPN 172 Query: 236 DE-------ENCWALNVNELRRAVQEAKDHCDPKVLCIINP--GNPTGQVQSRKCIEDVI 286 ++ L N++ + + I+ P GN + +E + Sbjct: 173 SPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVEPVAGNMNCVPPAPGFLEGLR 232 Query: 287 HFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGE 346 E + L+ DEV + +V Y S G Sbjct: 233 EACDEHGVVLIFDEV------------MTGFRVALGGAQAYYGVTPDLSTFGKIIGGGMP 280 Query: 347 CGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREK 406 G GG E++ + V P++ A + + ++ ++ + Sbjct: 281 VGAFGGKREIMQQISPL--GPVYQAGTLSGNPLAMAAGLTTLR--LISRPGFHDELTAYT 336 Query: 407 ESVLGNLAKKAKLTEDLFNQVPGIHCNPLQ--GAMYAFPRIFIPAKAVEAAQAHQMAPDM 464 +L L ++A GI Q G + E A + Sbjct: 337 TRMLDGLQQRADAA--------GIPFVTTQAGGMFGLYFSGADAIVTFEDVMASDVERFK 388 Query: 465 FYCMKLLEETGICVVPGSGF 484 + L+ + G+ + P S F Sbjct: 389 RFFH-LMLDGGVYLAP-SAF 406 >5OFN-A nrPDB Length = 330 Score = 33.3 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 52/160 (32%), Gaps = 7/160 (4%) Query: 307 YSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYR----GGYMEVINLHPE 362 R SF + N+ L F+S+++ R +M L Sbjct: 45 SDTYVRHLSFSSSEELRDYLVNRNLPLHLFYSSAR--YQLPSARNMEEKAWMGSDLLFDI 102 Query: 363 IKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTED 422 L KL S+R CP + V E E S + L ++ ED Sbjct: 103 DADHLCKLRSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQTRNLVEILED 162 Query: 423 LFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAP 462 F P ++ + +G + + +++ + ++A Sbjct: 163 DFGLKPKVYFSGNRG-FHVQVDCYGNCALLDSDERKEIAE 201 >2QMA-A nrPDB Length = 497 Score = 33.0 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 15/143 (10%), Positives = 42/143 (29%), Gaps = 25/143 (17%) Query: 182 YLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCW 241 T+G + L + +G I P Y+ + + + + ++ + + W Sbjct: 162 IFTSGGTQSNQMGLMLARDWIADKLSGHSIQKLGLPDYADKLRIVCSKKSHFTVQKSASW 221 Query: 242 -----------------ALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSR---KC 281 +++ +L + +AK + T Sbjct: 222 MGLGEKAVMTVDANADGTMDITKLDEVIAQAKAEGLIPFAIVG-----TAGTTDHGAIDD 276 Query: 282 IEDVIHFAWEEKLFLLADEVYQD 304 ++ + A + +++ D Y Sbjct: 277 LDFIADMAVKHDMWMHVDGAYGG 299 >3WY7-A nrPDB Length = 404 Score = 33.0 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 33/250 (13%), Positives = 71/250 (28%), Gaps = 47/250 (18%) Query: 111 QVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRR 170 + L +P++LD L+ GG G G + E + Sbjct: 66 DYLGLSQHPDVLDGG----------VEALRTWGG-GAGGSRLVTGNTELHEAFEHQLASF 114 Query: 171 DGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQ 230 G A + ++G + L L G + + +++++ + Sbjct: 115 LGAESA----LVFSSGYT-ANLGALVALSGPGSLIVSDAL-------SHASLVDACRLSR 162 Query: 231 VNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRK----CIEDVI 286 + + + + + + T V S + D+ Sbjct: 163 ARVVVSPHRD-------VDAVDAALAARTEERAVVV------TESVFSADGDLAPLRDLH 209 Query: 287 HFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGE 346 LL DE + V + +L+E+G + ++ + + SK + Sbjct: 210 AVCRRHGALLLVDEAHGLGVRGTRGQ-----GLLHEVGLAGAPDIVMTTT--LSKALGSQ 262 Query: 347 CGYRGGYMEV 356 G G V Sbjct: 263 GGAVLGPEAV 272 >3GZD-A nrPDB Length = 440 Score = 32.6 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 49/320 (15%), Positives = 99/320 (30%), Gaps = 53/320 (16%) Query: 124 SPSFPEDAKKRARRILQACGGNSLGSYSASQG----VNCIREDVAAYITRRDGGVPADPD 179 +P PE + + + GN YSA + +N RE +A I + P Sbjct: 35 TPLEPE-VIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGK-------PQ 86 Query: 180 NIYLTTGASDGISTILKILVSGGGKSRTGVMIP----IP---QYPLYSAVISELDAIQVN 232 +I T+G ++ + ++ +V ++T P P + E D+I++ Sbjct: 87 DIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLP 146 Query: 233 Y-YLDEENCWALNV-------NELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIED 284 +L EE A+ + A +++ I+ N TG V I Sbjct: 147 LEHLVEEQVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQ 206 Query: 285 VIHFAWEEKL-----FLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHST 339 I +E++ +L V++ + ++V E + F+ Sbjct: 207 RIKALNQERVAAGLPPIL--------VHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGP 258 Query: 340 SKGYMGECGYRGGYMEVINLHPEIKGQLVKL---LSVRLCPPVSGQAAMDIVVNPPVAGE 396 R G + + L + P + + Sbjct: 259 ----------RIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVT 308 Query: 397 ESFEQFSREKESVLGNLAKK 416 ++ E + V L ++ Sbjct: 309 QNCEAYEAHMRDVRDYLEER 328 >5KR5-A nrPDB Length = 479 Score = 32.6 bits (72), Expect = 0.47, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 77/278 (27%), Gaps = 35/278 (12%) Query: 245 VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKC--IEDVIHFAWEEKLFLLADEVY 302 V EL + + A++ D I P TG + E + + + L+ADEV Sbjct: 225 VEELEKLI--AREGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAVLRKHDILLIADEVV 282 Query: 303 QDN---VYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINL 359 + K L + +S S S+ + + Sbjct: 283 CGFGRLGSKTGSEHYGIKPDLITVAKGLTSAYAPLSAVIVSEKV---------WDVIEKG 333 Query: 360 HPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKL 419 E ++ PV AA+ + E+E++ GN A Sbjct: 334 SRE--HGVMGHGWTYSGHPVCAAAALANLD-------------ILERENLTGNAADVGAY 378 Query: 420 TEDLFNQVPGIHCNPLQ--GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGI- 476 + ++ G H + G F+ K + LE+ I Sbjct: 379 LQQRLHEAFGAHPLVGEVRGVGMLAALEFMADKGARTPFDPALKVSQKVAAAALEDGLIV 438 Query: 477 -CVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKD 513 + G G R + V K +V D Sbjct: 439 RALPHGDILGFAPPLVTTRAEVDEIVAIAKEAFDEVAD 476 >1PL8-A nrPDB Length = 356 Score = 32.2 bits (71), Expect = 0.58, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 46/134 (34%), Gaps = 28/134 (20%) Query: 161 EDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYS 220 +++A + +G + P+ TGA I + SGG G+ + PL Sbjct: 229 QEIARKV---EGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLH 285 Query: 221 AVISELDAIQVNYYLDEENCWALNVNELR--------------------RAVQEAKDHCD 260 A I E+D V Y N W + ++ L A + K Sbjct: 286 AAIREVDIKGVFRYC---NTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLG 342 Query: 261 PKVLCIINPG--NP 272 K++ +P NP Sbjct: 343 LKIMLKCDPSDQNP 356 >6C55-A nrPDB Length = 340 Score = 31.8 bits (70), Expect = 0.75, Method: Composition-based stats. Identities = 38/207 (18%), Positives = 69/207 (33%), Gaps = 27/207 (13%) Query: 34 VLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRA 93 V+ +RP RS + + P +AV+ A ++L EI+ ++ + +P E Sbjct: 44 VIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLP-DEIQGDVYKNEIEPNLEK--- 99 Query: 94 NIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKR------ARRILQACGGNSL 147 +A A + L +P P +R A L ++ Sbjct: 100 --HNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDAS 157 Query: 148 G-----SYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGG 202 G + S ++G+ R V + + + L G S I + + LV G Sbjct: 158 GQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAG 217 Query: 203 GKSRTGVMIPIPQYPLYSAVISELDAI 229 + Y V+ E+ I Sbjct: 218 YQPELA----------YFEVLHEMKLI 234 >5LH9-A nrPDB Length = 458 Score = 31.4 bits (69), Expect = 0.90, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 56/200 (28%), Gaps = 35/200 (17%) Query: 133 KRARRILQACGGNSLGSYSASQGVNCIRE-DVAAYITRRDGGVPADPDNIYLTTGASDGI 191 + + + A + L Y G+ R D+A +T + ++G SD + Sbjct: 71 RASVKAAIAAQLDELAYYQTFDGIAHPRVFDLAERLTGMFAQERMA--RVLFSSGGSDAV 128 Query: 192 STILKIL----VSGGGKSRTGVMIPIPQYP---------------LYSAVISELDAIQVN 232 T LK+ ++ G RT + Y Y+ ++ Sbjct: 129 ETALKMARQYWIASGEPGRTRFLSLRNGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLLD 188 Query: 233 YYLDEENCWALN---------VNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQ--SRKC 281 N W + +L + A I P G V Sbjct: 189 TPWLYRNPWDCRDPQALTAHCIRQLEEQI--ALLGAQTIAALIAEPVQGAGGVIVPPADY 246 Query: 282 IEDVIHFAWEEKLFLLADEV 301 + + L+ADEV Sbjct: 247 WPRLREVCDRHGILLIADEV 266 >6EEW-A nrPDB Length = 500 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 12/91 (13%), Positives = 28/91 (30%), Gaps = 5/91 (5%) Query: 217 PLYSAVISELDAIQVNYYLDE---ENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPT 273 ++ N L E + ++ LR+ V++ + G T Sbjct: 204 TMFPKTCKLAGIYPNNIRLIPTTVETDFGISPQVLRKMVEDDVAAGYVPLFLCATLG--T 261 Query: 274 GQVQSRKCIEDVIHFAWEEKLFLLADEVYQD 304 + ++ + A E +++ D Y Sbjct: 262 TSTTATDPVDSLSEIANEFGIWIHVDAAYAG 292 >2GRU-A nrPDB Length = 368 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 11/73 (15%) Query: 276 VQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 V S K +E I+F K+ +L++++Y+ K +++E G +ELA Sbjct: 208 VYSPKQLETFINFCISAKMSVLSEDIYEKK-----------KGLIFEYGHTIGHAIELAE 256 Query: 336 FHSTSKGYMGECG 348 + G G Sbjct: 257 QGGITHGEAIAVG 269 >6JEQ-A nrPDB Length = 675 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 20/49 (40%), Gaps = 4/49 (8%) Query: 261 PKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSP 309 P+ +P NP ++ ++ +I L ++ D VY VY Sbjct: 244 PEGSYSTDPHNPAARIL---ELKRLIQKLHARGLRVIMDVVYNH-VYDG 288 >6CBN-A nrPDB Length = 438 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 32/101 (31%), Gaps = 8/101 (7%) Query: 210 MIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINP 269 ++ Y Y + +A + D + ++ LR + + + + Sbjct: 145 LLLSAGYHGYDPMWYPSEA-PLEPNADGVVDFFFDLGLLRELL---RAPERVAAVVVS-- 198 Query: 270 GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPD 310 P S ++ + L+ADEV Y+P Sbjct: 199 --PDHMHLSPGWYRELRRLCSAAGVVLVADEVKVGLRYAPG 237 >4RIT-B nrPDB Length = 486 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 42/145 (28%), Gaps = 14/145 (9%) Query: 182 YLTTGASDGISTILKILVS-GGGKSRTGV--MIPIPQY--------PLYSAVISELDAIQ 230 LT+G S L + + G+ + P L A + Sbjct: 149 VLTSGGSLANLQALAVARNVAFDSVEPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTA 208 Query: 231 VNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAW 290 + ++ +LR + +A+ + T + + ++ A Sbjct: 209 AVIPVRATADSRMDPEDLRARIDQARGAGQHP--FCVVATAGTTTTGNIDPLAEIGAIAR 266 Query: 291 EEKLFLLADEVYQD-NVYSPDCRFH 314 E L+ D Y V+S R+ Sbjct: 267 EHGLWFHVDAAYGGALVFSERHRWR 291 >4EQ5-A nrPDB Length = 571 Score = 30.3 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 57/182 (31%), Gaps = 12/182 (6%) Query: 70 LKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPE 129 + + EIE ++ + + N ++ QP+T R L + S Sbjct: 87 INSEEIENSVRDTGDLGESIALALNKRKQKSFFSQPLTIERVYNTLVKIAEASGAGSQDR 146 Query: 130 DAKKRARRILQACGGNSLGSYSASQGVNC-------IREDVAAYITRRDGGVPADPDNIY 182 K A + A G+ +R+ +A R V + Y Sbjct: 147 KLKYLANLFMDASPDEGKYLARTVLGIMRTGVAEGLLRDALADAFKVRVELV----ERAY 202 Query: 183 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWA 242 + T + G + L G ++ + + P P+ + + + + V + E Sbjct: 203 MLT-SDFGFVAKVAKLEGDEGLAKVKIQVGKPIKPMLAQMAANVREALVEMGGEAEFEIK 261 Query: 243 LN 244 + Sbjct: 262 YD 263 >4UHN-A nrPDB Length = 468 Score = 29.9 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 18/52 (34%), Gaps = 1/52 (1%) Query: 251 AVQEAKDHCDPKVLCIINPGNPTGQVQSRK-CIEDVIHFAWEEKLFLLADEV 301 + E D + + + G + K ++ + + L+ DEV Sbjct: 230 KLIELHDASNIAAVIVEPMSGSAGVIVPPKGYLQRLREICDANDILLIFDEV 281 >4JBE-A nrPDB Length = 445 Score = 29.9 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 38/117 (32%), Gaps = 15/117 (12%) Query: 197 ILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQ-VNYYLDEENCWALNVNELRRAVQEA 255 L G + ++P P+ A++ D + V E+ AL + + V+ Sbjct: 201 ALTDSGIDANVVQLVPRPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTL 260 Query: 256 KDHCDPKVLCIINPGNPTGQVQSRKCIEDVI-------HFAWEEKLFLLADEVYQDN 305 VL + + R + ++ L L+ D VY++ Sbjct: 261 AHADGGGVLYVD-------EKADRDTVRSLVVNSLDRLGVCNRLNLLLIHDAVYEEF 310 >2DHM-A nrPDB Length = 107 Score = 29.5 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 32/105 (30%), Gaps = 7/105 (6%) Query: 276 VQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELAS 335 + R+ IE+ + A++ + DE Y+ NV + V E N Sbjct: 8 MMIRERIEEKLRAAFQPVFLEVVDESYRHNVPAGSESHFKVVLVSDRFTGERFLNRHRMI 67 Query: 336 FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVS 380 + + ++ + + LH + L P Sbjct: 68 YSTLAEELSTT-------VHALALHTYTIKEWEGLQDTVFASPPC 105 >4WQ5-A nrPDB Length = 343 Score = 28.7 bits (62), Expect = 5.7, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 30/85 (35%), Gaps = 3/85 (3%) Query: 134 RARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGIST 193 + +R L G L +R +A + +R G V GA I+ Sbjct: 250 KCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGA--MIAY 307 Query: 194 ILKILVSGGGKSRTGVMIPIPQYPL 218 + G + GV + P++PL Sbjct: 308 AGMVRFKAGATADLGVSV-RPRWPL 331 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.115 0.287 Lambda K H 0.267 0.0351 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,380,858 Number of Sequences: 36641 Number of extensions: 596933 Number of successful extensions: 2435 Number of sequences better than 10.0: 169 Number of HSP's better than 10.0 without gapping: 144 Number of HSP's successfully gapped in prelim test: 101 Number of HSP's that attempted gapping in prelim test: 1872 Number of HSP's gapped (non-prelim): 276 length of query: 523 length of database: 10,336,785 effective HSP length: 102 effective length of query: 421 effective length of database: 6,599,403 effective search space: 2778348663 effective search space used: 2778348663 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.3 bits)