BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q8TBE9 (248 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4KNV-A nrPDB 495 e-141 2GFH-A nrPDB 493 e-140 2YY6-A nrPDB 56 1e-08 5OLW-A nrPDB 46 2e-05 2HSZ-A nrPDB 43 1e-04 4BX2-A nrPDB 43 1e-04 2P27-A nrPDB 42 3e-04 3KBB-A nrPDB 41 4e-04 4BKM-A nrPDB 41 6e-04 2HI0-A nrPDB 38 0.003 3NAS-A nrPDB 37 0.005 2C4N-A nrPDB 35 0.023 3PDW-A nrPDB 35 0.033 2X4D-A nrPDB 35 0.038 1TE2-A nrPDB 34 0.045 4RN3-A nrPDB 34 0.072 3L5K-A nrPDB 33 0.11 4G9B-A nrPDB 33 0.13 4GIB-A nrPDB 32 0.20 5BPD-A nrPDB 31 0.43 1PW5-A nrPDB 31 0.55 2B7N-A nrPDB 30 0.78 1RQL-A nrPDB 30 0.78 4PNH-A nrPDB 30 0.80 3HLT-A nrPDB 30 1.3 4I9G-A nrPDB 29 1.5 1CR6-A nrPDB 28 2.9 2HO4-A nrPDB 28 3.0 4Y2Y-A nrPDB 28 3.0 >4KNV-A nrPDB Length = 241 Score = 495 bits (1275), Expect = e-141, Method: Compositional matrix adjust. Identities = 237/239 (99%), Positives = 238/239 (99%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +RAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN Sbjct: 1 MRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 60 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 125 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV Sbjct: 61 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 120 Query: 126 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV 185 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV Sbjct: 121 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV 180 Query: 186 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCKV 244 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDC V Sbjct: 181 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCLV 239 >2GFH-A nrPDB Length = 260 Score = 493 bits (1268), Expect = e-140, Method: Compositional matrix adjust. Identities = 233/247 (94%), Positives = 243/247 (98%) Query: 1 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 60 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC Sbjct: 13 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 72 Query: 61 FHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTE 120 FHPY+TCITD+RTSHWEEAIQETKGGA NRKLAEECYFLWKSTRLQHM LA+DVKAMLTE Sbjct: 73 FHPYSTCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKSTRLQHMILADDVKAMLTE 132 Query: 121 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ 180 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDA+V+GGEQ+EEKPAPSIFY+CC+LLGVQ Sbjct: 133 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAIVIGGEQKEEKPAPSIFYHCCDLLGVQ 192 Query: 181 PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSI 240 PGDCVMVGDTLETDIQGGLNAGLKATVWINK+G VPL SSP+PHYMVSSVLELPALLQSI Sbjct: 193 PGDCVMVGDTLETDIQGGLNAGLKATVWINKSGRVPLTSSPMPHYMVSSVLELPALLQSI 252 Query: 241 DCKVSMS 247 DCKVSMS Sbjct: 253 DCKVSMS 259 >2YY6-A nrPDB Length = 213 Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 104/241 (43%), Gaps = 40/241 (16%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +R + FDLD TLID+A ++ + +K +L E ++P N Sbjct: 1 MRVILFDLDGTLIDSA---------------------KDIALALEKTLKELGLEEYYPDN 39 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTL----AEDVKAMLTEL 121 T + ++ K EE +++ L++ + ++ L L Sbjct: 40 V------TKYIGGGVRALLEKVLKDKFREEYVEVFRKHYLENPVVYTKPYPEIPYTLEAL 93 Query: 122 R-KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ 180 + K +L +++N + ++ ++ YFD +V G E+KP+P+ +LG + Sbjct: 94 KSKGFKLAVVSNKLEELSKKILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLEILGEE 153 Query: 181 PGDCVMVGDTLETDIQGGLNAGLKA--TVWINKNGIVPLKSSPVPHYMVSSVLELPALLQ 238 P ++VGDT + DI+ G AG K +W G V L S +P + +S +L L+ Sbjct: 154 PEKALIVGDT-DADIEAGKRAGTKTALALW----GYVKLNSQ-IPDFTLSRPSDLVKLMD 207 Query: 239 S 239 + Sbjct: 208 N 208 >5OLW-A nrPDB Length = 227 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 88/220 (40%), Gaps = 45/220 (20%) Query: 7 RAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNT 66 +AV FDLD + DTA +YH++ + + +++ + F+ Sbjct: 3 KAVLFDLDGVITDTA----------------EYHFRA-WKALAEEIGINGVDRQFN---- 41 Query: 67 CITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKA---------M 117 L+ E+++Q+ A + AEE L K ++ + +DV + Sbjct: 42 --EQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQL 99 Query: 118 LTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLL 177 L +LR + L + + +E YFDA+ E KPAP IF + + Sbjct: 100 LKDLRSNKIKIALASASKNGPF-LLERMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAV 158 Query: 178 GVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPL 217 GV P + + + D+ Q G+ A I +G +P+ Sbjct: 159 GVAPSESIGLEDS-----QAGIQA-------IKDSGALPI 186 >2HSZ-A nrPDB Length = 243 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 2/94 (2%) Query: 110 LAEDVKAMLTELRKEVRLL-LLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPS 168 L +VK L L+ + +L ++TN + + + A F ++ G E KP P+ Sbjct: 115 LYPNVKETLEALKAQGYILAVVTNKPTKHVQPILTAFGIDHLFSEMLGGQSLPEIKPHPA 174 Query: 169 IFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAG 202 FYY C G+ P + VGD+ + DI +AG Sbjct: 175 PFYYLCGKFGLYPKQILFVGDS-QNDIFAAHSAG 207 >4BX2-A nrPDB Length = 293 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 19/115 (16%) Query: 130 LTNGDRQTQREKIEACA-CQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVG 188 L++G R + A S A+VVG KP+P +F V P +MVG Sbjct: 181 LSDGSRTPGTGSLAAAVETASGRQALVVG------KPSPYMFQCITEDFSVDPARTLMVG 234 Query: 189 DTLETDIQGGLNAGLKATVWINKNGIVPLKSSP----------VPHYMVSSVLEL 233 D LETDI G G+ T + G+ L+ + VPHY V S+ +L Sbjct: 235 DRLETDILFGHRCGM--TTVLTLTGVSSLEEAQAYLTAGQRDLVPHYYVESIADL 287 >2P27-A nrPDB Length = 306 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 50/115 (43%), Gaps = 19/115 (16%) Query: 130 LTNGDRQTQREKIEACA-CQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVG 188 L++G R + A S A+VVG KP+P +F + P +MVG Sbjct: 186 LSDGSRTPGTGSLAAAVETASGRQALVVG------KPSPYMFECITENFSIDPARTLMVG 239 Query: 189 DTLETDIQGGLNAGLKATVWINKNGIVPLKSSP----------VPHYMVSSVLEL 233 D LETDI G G+ T + G+ L+ + VPHY V S+ +L Sbjct: 240 DRLETDILFGHRCGM--TTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADL 292 >3KBB-A nrPDB Length = 216 Score = 41.2 bits (95), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 42/82 (51%), Gaps = 1/82 (1%) Query: 123 KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPG 182 K ++L L T+ ++ E++ + YFD +V G + + KP P I+ L V P Sbjct: 99 KRIKLALATSTPQREALERLRRLDLEKYFDVMVFGDQVKNGKPDPEIYLLVLERLNVVPE 158 Query: 183 DCVMVGDTLETDIQGGLNAGLK 204 V+ D+ ++ ++ +AG++ Sbjct: 159 KVVVFEDS-KSGVEAAKSAGIE 179 >4BKM-A nrPDB Length = 309 Score = 40.8 bits (94), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/121 (30%), Positives = 50/121 (41%), Gaps = 16/121 (13%) Query: 127 LLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREE----KPAPSIFYYCCNLLGVQPG 182 LL+ TN D + E A V QR+ KP+P +F V P Sbjct: 185 LLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSPYMFQCITEDFSVDPA 244 Query: 183 DCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSP----------VPHYMVSSVLE 232 +MVGD LETDI G G+ T + G+ L+ + VPHY V S+ + Sbjct: 245 RTLMVGDRLETDILFGHRCGM--TTVLTLTGVSSLEEAQAYLTAGQRDLVPHYYVESIAD 302 Query: 233 L 233 L Sbjct: 303 L 303 >2HI0-A nrPDB Length = 240 Score = 38.1 bits (87), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/227 (22%), Positives = 94/227 (41%), Gaps = 25/227 (11%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEE--AEIICDKVQVKLSKECFH 62 + +A FD+D T++DT+ + + ++ + E V V +++ + Sbjct: 3 KYKAAIFDMDGTILDTSADLTSALNYAFEQTGHRHDFTVEDIKNFFGSGVVVAVTRALAY 62 Query: 63 PYNTCITDL-----RTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLA-EDVKA 116 + L + EA+ +T+ NR L E + + + Q T + Sbjct: 63 EAGSSRESLVAFGTKDEQIPEAVTQTE---VNRVL--EVFKPYYADHCQIKTGPFPGILD 117 Query: 117 MLTELR-KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCN 175 ++ LR K V+L +++N + + +E S FD + KPAP + C Sbjct: 118 LMKNLRQKGVKLAVVSNKPNEAVQVLVEELFPGS-FDFALGEKSGIRRKPAPDMTSECVK 176 Query: 176 LLGVQPGDCVMVGDTLETDIQGGLNA---------GLKATVWINKNG 213 +LGV CV +GD+ E DIQ N+ G ++ ++ K+G Sbjct: 177 VLGVPRDKCVYIGDS-EIDIQTARNSEMDEIAVNWGFRSVPFLQKHG 222 >3NAS-A nrPDB Length = 233 Score = 37.4 bits (85), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/208 (22%), Positives = 80/208 (38%), Gaps = 31/208 (14%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 ++AV FDLD + DTA +YH+ I +++ + ++ N Sbjct: 2 LKAVIFDLDGVITDTA----------------EYHFLAWKHI-AEQIDIPFDRDM----N 40 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLA----ED----VKAM 117 + + E+I G AE+ + + R M ++ ED + + Sbjct: 41 ERLKGISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRL 100 Query: 118 LTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLL 177 L +L+ E + L + R + + A F A+V + KP P IF +L Sbjct: 101 LCQLKNENIKIGLASSSRNAPK-ILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAML 159 Query: 178 GVQPGDCVMVGDTLETDIQGGLNAGLKA 205 V P DC + D E I +AG+ A Sbjct: 160 DVSPADCAAIEDA-EAGISAIKSAGMFA 186 >2C4N-A nrPDB Length = 250 Score = 35.4 bits (80), Expect = 0.023, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 2/72 (2%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINK-NGIVPLKSSPV 222 KP+P I N + + V+VGD L TDI G AGL+ + ++ + + + S P Sbjct: 176 KPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPF 235 Query: 223 -PHYMVSSVLEL 233 P ++ SV E+ Sbjct: 236 RPSWIYPSVAEI 247 >3PDW-A nrPDB Length = 266 Score = 35.0 bits (79), Expect = 0.033, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 21/40 (52%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGL 203 KP I +LG + +MVGD TDI G+NAG+ Sbjct: 183 KPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGM 222 >2X4D-A nrPDB Length = 271 Score = 34.7 bits (78), Expect = 0.038, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 22/42 (52%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKA 205 KP+P F +GV+ VM+GD + D+ G G++A Sbjct: 190 KPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRA 231 >1TE2-A nrPDB Length = 226 Score = 34.3 bits (77), Expect = 0.045, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 79/195 (40%), Gaps = 33/195 (16%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 ++ A FD+D LID+ R L+V+ L + E + D + +++ Sbjct: 8 QILAAIFDMDGLLIDSEPLWDRAELDVMASLGVDISRRNE---LPDTLGLRI-------- 56 Query: 65 NTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKE 124 D+ W ++ G + +++ E + ++L E+ + +L +R+ Sbjct: 57 -----DMVVDLWYA--RQPWNGPSRQEVVERVIA-------RAISLVEETRPLLPGVREA 102 Query: 125 VRL-----LL--LTNGDRQTQREKI-EACACQSYFDAVVVGGEQREEKPAPSIFYYCCNL 176 V L LL L + EK+ + FDA+ + KP P ++ C Sbjct: 103 VALCKEQGLLVGLASASPLHMLEKVLTMFDLRDSFDALASAEKLPYSKPHPQVYLDCAAK 162 Query: 177 LGVQPGDCVMVGDTL 191 LGV P CV + D++ Sbjct: 163 LGVDPLTCVALEDSV 177 >4RN3-A nrPDB Length = 213 Score = 33.9 bits (76), Expect = 0.072, Method: Compositional matrix adjust. Identities = 42/204 (20%), Positives = 78/204 (38%), Gaps = 23/204 (11%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 ++AV +D D + D+ A+ +++++ ++ E + + ++E + Sbjct: 11 IKAVIYDCDGVMFDSFEANLAFYQRIMEMMGRPRLSRDNEEQM-RILHTYANREVLAHFF 69 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 125 D WEEA++ G R+L + M + E + L L+ V Sbjct: 70 PSPGD-----WEEAVR-CAGAIDYREL------------VPLMIMEEGFREALDTLKGRV 111 Query: 126 RLLLLTNGDRQTQREKI-EACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDC 184 L + TN R T + + + SYF V+ KP P G+ P + Sbjct: 112 GLGVCTN--RSTSMDMVLRLFSLDSYFSIVMTASRVTNPKPHPEPLLKVLEHFGIGPREA 169 Query: 185 VMVGDTLETDIQGGLNAGLKATVW 208 + VGD+ E D AG+ + Sbjct: 170 LFVGDS-EVDRLSAEAAGVPFVAY 192 >3L5K-A nrPDB Length = 250 Score = 33.1 bits (74), Expect = 0.11, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 87/228 (38%), Gaps = 58/228 (25%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYK-----------EEAEIICDKVQV 54 V + FD+D L+DT E+ KY + E A+II D +Q+ Sbjct: 30 VTHLIFDMDGLLLDTERLYSVVFQEICNRYDKKYSWDVKSLVMGKKALEAAQIIIDVLQL 89 Query: 55 KLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDV 114 +SK EE ++E++ KL E ++ + L M AE Sbjct: 90 PMSK------------------EELVEESQ-----TKLKE----VFPTAAL--MPGAE-- 118 Query: 115 KAMLTELRKE-VRLLLLTNG-----DRQTQREKIEACACQSYFDAVVVGG--EQREEKPA 166 ++ LRK + L T+ D +T R K S F +V+G E + KP Sbjct: 119 -KLIIHLRKHGIPFALATSSRSASFDMKTSRHK----EFFSLFSHIVLGDDPEVQHGKPD 173 Query: 167 PSIFYYCCNLLGVQPG--DCVMVGDTLETDIQGGLNAGLKATVWINKN 212 P IF C P C++ D ++ L AG++ + + N Sbjct: 174 PDIFLACAKRFSPPPAMEKCLVFEDA-PNGVEAALAAGMQVVMVPDGN 220 >4G9B-A nrPDB Length = 243 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 47/238 (19%), Positives = 89/238 (37%), Gaps = 43/238 (18%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 +++ V FDLD + DTA H++ +I + + + + + + Sbjct: 4 KLQGVIFDLDGVITDTA----------------HLHFQAWQQIAAE-IGISIDAQ----F 42 Query: 65 NTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAE-DVKAMLTELRK 123 N + + I + G + E ++ L +L E V A+L +R Sbjct: 43 NESLKGISRDESLRRILQHGGKEGDFNSQERAQLAYRKNLLYVHSLRELTVNAVLPGIRS 102 Query: 124 ---EVRLLLLTNGDRQTQREK---IEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLL 177 ++R ++ G + A + +F + + KP P IF C L Sbjct: 103 LLADLRAQQISVGLASVSLNAPTILAALELREFFTFCADASQLKNSKPDPEIFLAACAGL 162 Query: 178 GVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPA 235 GV P C+ + D Q G++A IN +G ++S + + + L LP+ Sbjct: 163 GVPPQACIGI-----EDAQAGIDA-------INASG---MRSVGIGAGLTGAQLLLPS 205 >4GIB-A nrPDB Length = 250 Score = 32.3 bits (72), Expect = 0.20, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 19/40 (47%) Query: 151 FDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDT 190 FD + G+ + KP P IF L V P +C+ + D Sbjct: 157 FDFIADAGKCKNNKPHPEIFLMSAKGLNVNPQNCIGIEDA 196 >5BPD-A nrPDB Length = 264 Score = 31.2 bits (69), Expect = 0.43, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 27/55 (49%) Query: 182 GDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPAL 236 D + LE DI ++ G+K + + KN + LK+S + Y LEL AL Sbjct: 153 ADDGFIAVNLEDDIIKAVDRGVKTKILLTKNLLPRLKASKIIDYAKEGKLELRAL 207 >1PW5-A nrPDB Length = 253 Score = 30.8 bits (68), Expect = 0.55, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 20/40 (50%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGL 203 KP P + GV MVGD L TD++ G NAG+ Sbjct: 183 KPNPLVVDVISEKFGVPKERMAMVGDRLYTDVKLGKNAGI 222 >2B7N-A nrPDB Length = 273 Score = 30.4 bits (67), Expect = 0.78, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 25/41 (60%), Gaps = 3/41 (7%) Query: 85 GGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 125 GGA+N +L + + K T L+H+ +D+K+ LT RK + Sbjct: 142 GGASNHRLGLDDALMLKDTHLRHV---KDLKSFLTHARKNL 179 >1RQL-A nrPDB Length = 267 Score = 30.4 bits (67), Expect = 0.78, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 61/133 (45%), Gaps = 4/133 (3%) Query: 74 SHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKE-VRLLLLTN 132 S W ++ A +++ EE + + ++ + VK ++ LR+ +++ T Sbjct: 68 SEWNRVFRQLPTEADIQEMYEEFEEILFAILPRYASPINAVKEVIASLRERGIKIGSTTG 127 Query: 133 GDRQTQREKIEACACQSYF-DAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD-CVMVGDT 190 R+ + A Q Y D +V + +P P + Y LGV P + + VGDT Sbjct: 128 YTREMMDIVAKEAALQGYKPDFLVTPDDVPAGRPYPWMCYKNAMELGVYPMNHMIKVGDT 187 Query: 191 LETDIQGGLNAGL 203 + +D++ G NAG+ Sbjct: 188 V-SDMKEGRNAGM 199 >4PNH-A nrPDB Length = 199 Score = 30.4 bits (67), Expect = 0.80, Method: Compositional matrix adjust. Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 163 EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPV 222 KP P + + P D +VGD+L D+Q G G + + + G L + + Sbjct: 118 RKPMPGMMKLIAERFEIDPADTPVVGDSLR-DLQAGAALGFRPHLVLTGKGKKTLAAGGL 176 Query: 223 P 223 P Sbjct: 177 P 177 >3HLT-A nrPDB Length = 266 Score = 29.6 bits (65), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 23/51 (45%), Gaps = 6/51 (11%) Query: 153 AVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGL 203 A VVG KP + F G +P + VM+GD D+ G + G+ Sbjct: 174 ATVVG------KPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGM 218 >4I9G-A nrPDB Length = 361 Score = 29.3 bits (64), Expect = 1.5, Method: Compositional matrix adjust. Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 8/45 (17%) Query: 164 KPAPSIFYYCCNLLGVQPGD---CVMVGDTLETDIQGGLNAGLKA 205 KPAP++ V GD ++VGD L+TDI+G AGL + Sbjct: 194 KPAPALMTEA-----VARGDFRAALVVGDRLDTDIEGANAAGLPS 233 >1CR6-A nrPDB Length = 554 Score = 28.5 bits (62), Expect = 2.9, Method: Compositional matrix adjust. Identities = 14/60 (23%), Positives = 29/60 (48%), Gaps = 1/60 (1%) Query: 130 LTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGD 189 L +GD++ ++ C +FD ++ + KP P I+ + + L +P + V + D Sbjct: 127 LDDGDKRDSLAQM-MCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDD 185 >2HO4-A nrPDB Length = 259 Score = 28.5 bits (62), Expect = 3.0, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 6/51 (11%) Query: 153 AVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGL 203 A+VVG KP + F P + VM+GD D+ G N G+ Sbjct: 174 AMVVG------KPEKTFFLEALRDADCAPEEAVMIGDDCRDDVDGAQNIGM 218 >4Y2Y-A nrPDB Length = 561 Score = 28.5 bits (62), Expect = 3.0, Method: Compositional matrix adjust. Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 4/80 (5%) Query: 114 VKAMLTELRKEVRLLLLTNG--DRQTQREKIEACACQ--SYFDAVVVGGEQREEKPAPSI 169 ++A L +K +LTN D + +R+ + C+ +FD ++ + KP P I Sbjct: 106 LQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQI 165 Query: 170 FYYCCNLLGVQPGDCVMVGD 189 + + + L P + V + D Sbjct: 166 YKFLLDTLKASPSEVVFLDD 185 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2GFH-A nrPDB 381 e-106 4KNV-A nrPDB 372 e-104 2YY6-A nrPDB 204 2e-53 5OLW-A nrPDB 168 2e-42 4BKM-A nrPDB 127 6e-30 2HSZ-A nrPDB 124 5e-29 4BX2-A nrPDB 110 6e-25 2P27-A nrPDB 107 4e-24 3KBB-A nrPDB 101 4e-22 Sequences not found previously or not previously below threshold: 3NAS-A nrPDB 93 2e-19 4G9B-A nrPDB 88 2e-18 4GIB-A nrPDB 82 2e-16 1RQL-A nrPDB 73 1e-13 4RN3-A nrPDB 69 2e-12 2HDO-A nrPDB 65 2e-11 2HI0-A nrPDB 63 9e-11 1TE2-A nrPDB 62 3e-10 3L5K-A nrPDB 58 5e-09 2C4N-A nrPDB 53 9e-08 2X4D-A nrPDB 53 1e-07 3QUB-A nrPDB 52 2e-07 1PW5-A nrPDB 51 4e-07 3PDW-A nrPDB 50 8e-07 3NUQ-A nrPDB 48 3e-06 4Y2Y-A nrPDB 47 9e-06 4PNH-A nrPDB 45 3e-05 2B0C-A nrPDB 44 4e-05 1CR6-A nrPDB 43 9e-05 4JB3-A nrPDB 43 2e-04 3L8F-A nrPDB 43 2e-04 3L1U-A nrPDB 43 2e-04 2O2X-A nrPDB 41 7e-04 4I9G-A nrPDB 38 0.003 2HO4-A nrPDB 37 0.010 3L8H-A nrPDB 36 0.011 1U7O-A nrPDB 36 0.015 3HLT-A nrPDB 36 0.016 2QLT-A nrPDB 35 0.030 5YA1-A nrPDB 33 0.14 3IRU-A nrPDB 32 0.21 6GRI-C nrPDB 30 0.91 2WM8-A nrPDB 30 1.2 1PZ1-A nrPDB 29 1.5 3WDH-A nrPDB 28 4.0 5MSN-A nrPDB 28 4.1 5OKI-C nrPDB 28 4.9 2LEF-A nrPDB 27 7.7 >2GFH-A nrPDB Length = 260 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 233/247 (94%), Positives = 243/247 (98%) Query: 1 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 60 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC Sbjct: 13 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 72 Query: 61 FHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTE 120 FHPY+TCITD+RTSHWEEAIQETKGGA NRKLAEECYFLWKSTRLQHM LA+DVKAMLTE Sbjct: 73 FHPYSTCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKSTRLQHMILADDVKAMLTE 132 Query: 121 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ 180 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDA+V+GGEQ+EEKPAPSIFY+CC+LLGVQ Sbjct: 133 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAIVIGGEQKEEKPAPSIFYHCCDLLGVQ 192 Query: 181 PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSI 240 PGDCVMVGDTLETDIQGGLNAGLKATVWINK+G VPL SSP+PHYMVSSVLELPALLQSI Sbjct: 193 PGDCVMVGDTLETDIQGGLNAGLKATVWINKSGRVPLTSSPMPHYMVSSVLELPALLQSI 252 Query: 241 DCKVSMS 247 DCKVSMS Sbjct: 253 DCKVSMS 259 >4KNV-A nrPDB Length = 241 Score = 372 bits (954), Expect = e-104, Method: Composition-based stats. Identities = 237/239 (99%), Positives = 238/239 (99%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +RAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN Sbjct: 1 MRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 60 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 125 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV Sbjct: 61 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 120 Query: 126 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV 185 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV Sbjct: 121 RLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGDCV 180 Query: 186 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCKV 244 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDC V Sbjct: 181 MVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSIDCLV 239 >2YY6-A nrPDB Length = 213 Score = 204 bits (519), Expect = 2e-53, Method: Composition-based stats. Identities = 55/239 (23%), Positives = 103/239 (43%), Gaps = 36/239 (15%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +R + FDLD TLID+A ++ + +K +L E ++P N Sbjct: 1 MRVILFDLDGTLIDSA---------------------KDIALALEKTLKELGLEEYYPDN 39 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLA----EDVKAMLTEL 121 T + ++ K EE +++ L++ + ++ L L Sbjct: 40 V------TKYIGGGVRALLEKVLKDKFREEYVEVFRKHYLENPVVYTKPYPEIPYTLEAL 93 Query: 122 R-KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ 180 + K +L +++N + ++ ++ YFD +V G E+KP+P+ +LG + Sbjct: 94 KSKGFKLAVVSNKLEELSKKILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLEILGEE 153 Query: 181 PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQS 239 P ++VGDT + DI+ G AG K + G V L S +P + +S +L L+ + Sbjct: 154 PEKALIVGDT-DADIEAGKRAGTKTA--LALWGYVKLNS-QIPDFTLSRPSDLVKLMDN 208 >5OLW-A nrPDB Length = 227 Score = 168 bits (425), Expect = 2e-42, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 88/220 (40%), Gaps = 45/220 (20%) Query: 7 RAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNT 66 +AV FDLD + DTA +YH++ + + +++ + F+ Sbjct: 3 KAVLFDLDGVITDTA----------------EYHFRA-WKALAEEIGINGVDRQFN---- 41 Query: 67 CITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKA---------M 117 L+ E+++Q+ A + AEE L K ++ + +DV + Sbjct: 42 --EQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQL 99 Query: 118 LTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLL 177 L +LR + L + + +E YFDA+ E KPAP IF + + Sbjct: 100 LKDLRSNKIKIALASASKNGPF-LLERMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAV 158 Query: 178 GVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPL 217 GV P + + + D+ Q G+ A I +G +P+ Sbjct: 159 GVAPSESIGLEDS-----QAGIQA-------IKDSGALPI 186 >4BKM-A nrPDB Length = 309 Score = 127 bits (318), Expect = 6e-30, Method: Composition-based stats. Identities = 42/150 (28%), Positives = 61/150 (40%), Gaps = 20/150 (13%) Query: 104 RLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQRE- 162 +M L + V+ L++ LL+ TN D + E A V QR+ Sbjct: 166 HFSYMKLTKAVRY----LQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQA 221 Query: 163 ---EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKS 219 KP+P +F V P +MVGD LETDI G G+ T + G+ L+ Sbjct: 222 DIIGKPSPYMFQCITEDFSVDPARTLMVGDRLETDILFGHRCGM--TTVLTLTGVSSLEE 279 Query: 220 SP----------VPHYMVSSVLELPALLQS 239 + VPHY V S+ +L L+ Sbjct: 280 AQAYLTAGQRDLVPHYYVESIADLMEGLED 309 >2HSZ-A nrPDB Length = 243 Score = 124 bits (310), Expect = 5e-29, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 89/254 (35%), Gaps = 46/254 (18%) Query: 2 GLSRVRAVFFDLDNTLIDT---AGASRRGMLEVIKLLQSKYHYKEEA------------- 45 G+++ + + FDLD TL+++ S L+ + L Q+ + Sbjct: 19 GMTQFKLIGFDLDGTLVNSLPDLALSINSALKDVNLPQASENLVMTWIGNGADVLSQRAV 78 Query: 46 EIICDKVQVKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRL 105 + C + + +L+++ F + + F + Sbjct: 79 DWACKQAEKELTEDEF----------------------------KYFKRQFGFYYGENLC 110 Query: 106 QHMTLAEDVKAMLTELRKEVR-LLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEK 164 L +VK L L+ + L ++TN + + + A F ++ G E K Sbjct: 111 NISRLYPNVKETLEALKAQGYILAVVTNKPTKHVQPILTAFGIDHLFSEMLGGQSLPEIK 170 Query: 165 PAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPH 224 P P+ FYY C G+ P + VGD+ + DI +AG + P Sbjct: 171 PHPAPFYYLCGKFGLYPKQILFVGDS-QNDIFAAHSAGCAVVGLTYGYNYNIPIAQSKPD 229 Query: 225 YMVSSVLELPALLQ 238 ++ ++ + Q Sbjct: 230 WIFDDFADILKITQ 243 >4BX2-A nrPDB Length = 293 Score = 110 bits (274), Expect = 6e-25, Method: Composition-based stats. Identities = 37/133 (27%), Positives = 51/133 (38%), Gaps = 16/133 (12%) Query: 121 LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQRE----EKPAPSIFYYCCNL 176 LR LL+ T+ D A V R+ KP+P +F Sbjct: 163 LRDPDCLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCITED 222 Query: 177 LGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSP----------VPHYM 226 V P +MVGD LETDI G G+ T + G+ L+ + VPHY Sbjct: 223 FSVDPARTLMVGDRLETDILFGHRCGM--TTVLTLTGVSSLEEAQAYLTAGQRDLVPHYY 280 Query: 227 VSSVLELPALLQS 239 V S+ +L L+ Sbjct: 281 VESIADLMEGLED 293 >2P27-A nrPDB Length = 306 Score = 107 bits (267), Expect = 4e-24, Method: Composition-based stats. Identities = 38/150 (25%), Positives = 58/150 (38%), Gaps = 17/150 (11%) Query: 104 RLQHMTLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQRE- 162 +H + A+ ++ LR LL+ T+ D A V R+ Sbjct: 152 YDEHFSFAK-LREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQA 210 Query: 163 ---EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKS 219 KP+P +F + P +MVGD LETDI G G+ T + G+ L+ Sbjct: 211 LVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGM--TTVLTLTGVSRLEE 268 Query: 220 SP----------VPHYMVSSVLELPALLQS 239 + VPHY V S+ +L L+ Sbjct: 269 AQAYLAAGQHDLVPHYYVESIADLTEGLED 298 >3KBB-A nrPDB Length = 216 Score = 101 bits (250), Expect = 4e-22, Method: Composition-based stats. Identities = 44/211 (20%), Positives = 84/211 (39%), Gaps = 44/211 (20%) Query: 6 VRAVFFDLDNTLIDTAG----ASRRGMLEVIKLLQSKYHYK-------EEAEIICDKVQV 54 + AV FD+D L+DT A RR K H + E I+ + +++ Sbjct: 1 MEAVIFDMDGVLMDTEPLYFEAYRRVAESYGKPYTEDLHRRIMGVPEREGLPILMEALEI 60 Query: 55 KLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDV 114 K S E F +++ EE ++ ++ V Sbjct: 61 KDSLENF---------------------------KKRVHEEKKRVFSELLKEN----PGV 89 Query: 115 KAMLTELR-KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYC 173 + L ++ K ++L L T+ ++ E++ + YFD +V G + + KP P I+ Sbjct: 90 REALEFVKSKRIKLALATSTPQREALERLRRLDLEKYFDVMVFGDQVKNGKPDPEIYLLV 149 Query: 174 CNLLGVQPGDCVMVGDTLETDIQGGLNAGLK 204 L V P V+ D+ ++ ++ +AG++ Sbjct: 150 LERLNVVPEKVVVFEDS-KSGVEAAKSAGIE 179 >3NAS-A nrPDB Length = 233 Score = 92.6 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 46/211 (21%), Positives = 76/211 (36%), Gaps = 37/211 (17%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 ++AV FDLD + DTA +YH+ + I +++ + Sbjct: 2 LKAVIFDLDGVITDTA----------------EYHFLA-WKHIAEQIDIPF-------DR 37 Query: 66 TCITDLRTSHWEEAIQETK--GGAANRKLAEECYFLWKSTRLQHMTLA---------EDV 114 L+ EE+++ GGA + E L + L + Sbjct: 38 DMNERLKGISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGI 97 Query: 115 KAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCC 174 +L +L+ E + L + R + + A F A+V + KP P IF Sbjct: 98 GRLLCQLKNENIKIGLASSSRNAP-KILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAA 156 Query: 175 NLLGVQPGDCVMVGDTLETDIQGGLNAGLKA 205 +L V P DC + D E I +AG+ A Sbjct: 157 AMLDVSPADCAAIEDA-EAGISAIKSAGMFA 186 >4G9B-A nrPDB Length = 243 Score = 88.4 bits (217), Expect = 2e-18, Method: Composition-based stats. Identities = 38/212 (17%), Positives = 80/212 (37%), Gaps = 37/212 (17%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 +++ V FDLD + DTA H++ + I ++ + + F+ Sbjct: 4 KLQGVIFDLDGVITDTA----------------HLHFQA-WQQIAAEIGISI-DAQFN-- 43 Query: 65 NTCITDLRTSHWEEAIQETK--GGAANRKLAEECYFLWKSTRLQHM---------TLAED 113 L+ +E+++ GG ++E L L ++ + Sbjct: 44 ----ESLKGISRDESLRRILQHGGKEGDFNSQERAQLAYRKNLLYVHSLRELTVNAVLPG 99 Query: 114 VKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYC 173 ++++L +LR + + L + + A + +F + + KP P IF Sbjct: 100 IRSLLADLRAQQISVGLASVSLNAPT-ILAALELREFFTFCADASQLKNSKPDPEIFLAA 158 Query: 174 CNLLGVQPGDCVMVGDTLETDIQGGLNAGLKA 205 C LGV P C+ + D + I +G+++ Sbjct: 159 CAGLGVPPQACIGIEDA-QAGIDAINASGMRS 189 >4GIB-A nrPDB Length = 250 Score = 82.2 bits (201), Expect = 2e-16, Method: Composition-based stats. Identities = 35/209 (16%), Positives = 71/209 (33%), Gaps = 37/209 (17%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 + A FDLD + DTA YHY + KV + + Sbjct: 26 IEAFIFDLDGVITDTAY----------------YHYMA-WRKLAHKVGIDI-------DT 61 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKL--AEECYFLWKSTRLQHMTLAEDV--------- 114 L+ E++ + EE + + +++L +++ Sbjct: 62 KFNESLKGISRMESLDRILEFGNKKYSFSEEEKVRMAEEKNNYYVSLIDEITSNDILPGI 121 Query: 115 KAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCC 174 +++L +++ + L++ + + FD + G+ + KP P IF Sbjct: 122 ESLLIDVKSNNIKIGLSSASKN-AINVLNHLGISDKFDFIADAGKCKNNKPHPEIFLMSA 180 Query: 175 NLLGVQPGDCVMVGDTLETDIQGGLNAGL 203 L V P +C+ + D I +A + Sbjct: 181 KGLNVNPQNCIGIEDA-SAGIDAINSANM 208 >1RQL-A nrPDB Length = 267 Score = 73.0 bits (177), Expect = 1e-13, Method: Composition-based stats. Identities = 51/268 (19%), Positives = 100/268 (37%), Gaps = 35/268 (13%) Query: 1 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 60 M ++ AV FD T +D G +++ +H K I ++ + + Sbjct: 1 MDRMKIEAVIFDWAGTTVD------YGCFAPLEVFMEIFH-KRGVAITAEEARKPMGLLK 53 Query: 61 FHPYNTCITDLR-TSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLT 119 R S W ++ A +++ EE + + ++ + VK ++ Sbjct: 54 IDHVRALTEMPRIASEWNRVFRQLPTEADIQEMYEEFEEILFAILPRYASPINAVKEVIA 113 Query: 120 ELRKEVRLLLLTNGDRQTQREKIEA-CACQSYF-DAVVVGGEQREEKPAPSIFYYCCNLL 177 LR+ + T G + + + A Q Y D +V + +P P + Y L Sbjct: 114 SLRERGIKIGSTTGYTREMMDIVAKEAALQGYKPDFLVTPDDVPAGRPYPWMCYKNAMEL 173 Query: 178 GVQP-GDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPV-------------- 222 GV P + VGDT+ +D++ G NAG+ I + + L V Sbjct: 174 GVYPMNHMIKVGDTV-SDMKEGRNAGMWTVGVILGSSELGLTEEEVENMDSVELREKIEV 232 Query: 223 ---------PHYMVSSVLELPALLQSID 241 H+ + ++ EL ++++ I+ Sbjct: 233 VRNRFVENGAHFTIETMQELESVMEHIE 260 >4RN3-A nrPDB Length = 213 Score = 68.7 bits (166), Expect = 2e-12, Method: Composition-based stats. Identities = 42/200 (21%), Positives = 71/200 (35%), Gaps = 25/200 (12%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYK--EEAEIICDKVQVKLSKECFHP 63 ++AV +D D + D+ A+ +++++ + EE I + F P Sbjct: 11 IKAVIYDCDGVMFDSFEANLAFYQRIMEMMGRPRLSRDNEEQMRILHTYANREVLAHFFP 70 Query: 64 YNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRK 123 WEEA++ G R+L + M + E + L L+ Sbjct: 71 SPGD--------WEEAVR-CAGAIDYREL------------VPLMIMEEGFREALDTLKG 109 Query: 124 EVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD 183 V L + TN + + SYF V+ KP P G+ P + Sbjct: 110 RVGLGVCTNRSTSMDM-VLRLFSLDSYFSIVMTASRVTNPKPHPEPLLKVLEHFGIGPRE 168 Query: 184 CVMVGDTLETDIQGGLNAGL 203 + VGD+ E D AG+ Sbjct: 169 ALFVGDS-EVDRLSAEAAGV 187 >2HDO-A nrPDB Length = 209 Score = 65.3 bits (157), Expect = 2e-11, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 79/235 (33%), Gaps = 33/235 (14%) Query: 7 RAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKY---HYKEEAEIICDKVQVKLSKECFHP 63 +A+ FD+D TL ++ A M EV+ + ++ + ++ +L Sbjct: 5 QALMFDIDGTLTNSQPAYTTVMREVLATYGKPFSPAQAQKTFPMAAEQAMTELG------ 58 Query: 64 YNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRK 123 + + + S Q + L + ++ +L Sbjct: 59 --------------------IAASEFDHFQAQYEDVMASHYDQ-IELYPGITSLFEQLPS 97 Query: 124 EVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD 183 E+RL ++T+ R + + + + + KP P + V P + Sbjct: 98 ELRLGIVTSQRRNELESGMRSYPFMMRMAVTISADDTPKRKPDPLPLLTALEKVNVAPQN 157 Query: 184 CVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQ 238 + +GD++ +D Q A + + + G+ P + L++ L + Sbjct: 158 ALFIGDSV-SDEQTAQAANVDFGLAV--WGMDPNADHQKVAHRFQKPLDILELFK 209 >2HI0-A nrPDB Length = 240 Score = 63.3 bits (152), Expect = 9e-11, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 84/213 (39%), Gaps = 16/213 (7%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYK-EEAE-IICDKVQVKLSKECFH 62 + +A FD+D T++DT+ + + ++ + E+ + V V +++ + Sbjct: 3 KYKAAIFDMDGTILDTSADLTSALNYAFEQTGHRHDFTVEDIKNFFGSGVVVAVTRALAY 62 Query: 63 PYNTCITDLR--TSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTL----AEDVKA 116 + L + E+ + NR L ++K H + + Sbjct: 63 EAGSSRESLVAFGTKDEQIPEAVTQTEVNRVL-----EVFKPYYADHCQIKTGPFPGILD 117 Query: 117 MLTELR-KEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCN 175 ++ LR K V+L +++N + + +E FD + KPAP + C Sbjct: 118 LMKNLRQKGVKLAVVSNKPNEAVQVLVEEL-FPGSFDFALGEKSGIRRKPAPDMTSECVK 176 Query: 176 LLGVQPGDCVMVGDTLETDIQGGLNAGLKATVW 208 +LGV CV +GD+ E DIQ N+ + Sbjct: 177 VLGVPRDKCVYIGDS-EIDIQTARNSEMDEIAV 208 >1TE2-A nrPDB Length = 226 Score = 61.8 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 39/205 (19%), Positives = 77/205 (37%), Gaps = 20/205 (9%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 ++ A FD+D LID+ R L+V+ L + E +++ + + ++ Sbjct: 8 QILAAIFDMDGLLIDSEPLWDRAELDVMASLGVDISRRNELPDTL-GLRIDMVVDLWY-- 64 Query: 65 NTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKE 124 +E ++ A + L EE L V+ + +++ Sbjct: 65 --ARQPWNGPSRQEVVERVIARAIS--LVEETR-----------PLLPGVREAVALCKEQ 109 Query: 125 VRLLLLTNGDRQTQREK-IEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD 183 L+ L + EK + + FDA+ + KP P ++ C LGV P Sbjct: 110 GLLVGLASASPLHMLEKVLTMFDLRDSFDALASAEKLPYSKPHPQVYLDCAAKLGVDPLT 169 Query: 184 CVMVGDTLETDIQGGLNAGLKATVW 208 CV + D++ + A +++ V Sbjct: 170 CVALEDSV-NGMIASKAARMRSIVV 193 >3L5K-A nrPDB Length = 250 Score = 57.6 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 38/209 (18%), Positives = 66/209 (31%), Gaps = 34/209 (16%) Query: 9 VFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNTCI 68 + FD+D L+DT E+ KY + ++ ++ K Sbjct: 33 LIFDMDGLLLDTERLYSVVFQEICNRYDKKYSWDVKSLVMGKKAL--------------- 77 Query: 69 TDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQ---HMTLAEDVKAMLTELRKEV 125 EA Q EE ++ + L + ++ LRK Sbjct: 78 ---------EAAQIIIDVLQLPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHG 128 Query: 126 RLLLLTNGDRQTQREKIEACACQ--SYFDAVVVGG--EQREEKPAPSIFYYCCNLLGVQP 181 L R + + + S F +V+G E + KP P IF C P Sbjct: 129 IPFALATSSRSASFDMKTSRHKEFFSLFSHIVLGDDPEVQHGKPDPDIFLACAKRFSPPP 188 Query: 182 --GDCVMVGDTLETDIQGGLNAGLKATVW 208 C++ D ++ L AG++ + Sbjct: 189 AMEKCLVFEDAP-NGVEAALAAGMQVVMV 216 >2C4N-A nrPDB Length = 250 Score = 53.3 bits (126), Expect = 9e-08, Method: Composition-based stats. Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 8/116 (6%) Query: 123 KEVRLLLLTNGDRQTQREKIEAC-ACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQP 181 + TN R AC A + + + KP+P I N + Sbjct: 135 ANGARFIATN-PDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHS 193 Query: 182 GDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPL---KSSPV-PHYMVSSVLEL 233 + V+VGD L TDI G AGL+ + + +G+ L S P P ++ SV E+ Sbjct: 194 EETVIVGDNLRTDILAGFQAGLETILVL--SGVSSLDDIDSMPFRPSWIYPSVAEI 247 >2X4D-A nrPDB Length = 271 Score = 52.9 bits (125), Expect = 1e-07, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 82/264 (31%), Gaps = 36/264 (13%) Query: 3 LSRVRAVFFDLDNTLIDTAGAS--------------RRGMLEVIKLLQSKYHYKEEAEII 48 L+ VR V D+ L D+ +R L+V + E Sbjct: 9 LAGVRGVLLDISGVLYDSGAGGGTAIAGSVEAVARLKRSRLKVRFCTNESAASRAELVGQ 68 Query: 49 CDKVQVKLSKECFH---PYNTCITDLRTSH----WEEAIQETKGGAA----NRKLAEECY 97 ++ +S++ P I R + ++ N + + Sbjct: 69 LQRLGFDISEQEVTAPAPAACQILKERGLRPYLLIHDGVRSEFDQIDTSNPNCVVIADAG 128 Query: 98 FLWKSTRLQHM--TLAEDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVV 155 + + + L E K +L L K T+G ++A A V Sbjct: 129 ESFSYQNMNNAFQVLMELEKPVLISLGKGRYYAA-TSGLMLDVGPYMKALEYACGIKAEV 187 Query: 156 VGGEQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIV 215 VG KP+P F +GV+ VM+GD + D+ G G++A Sbjct: 188 VG------KPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRP 241 Query: 216 PLKSSP--VPHYMVSSVLELPALL 237 + P V ++ E LL Sbjct: 242 SDEHHPEVKADGYVDNLAEAVDLL 265 >3QUB-A nrPDB Length = 243 Score = 52.2 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 68/212 (32%), Gaps = 29/212 (13%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 +++AV FD+D L ++ YH E + + LS+E + + Sbjct: 23 KLKAVLFDMDGVLFNS----------------MPYH-SEAWHQVMKTHGLDLSREEAYMH 65 Query: 65 NTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTL--AEDVKAMLTELR 122 S Q G A ++ E Y + +L +++ Sbjct: 66 ---AGRTGASTINIVFQRELGKEATQEEIESIYHEKSILFNSYPEAERMPGAWELLQKVK 122 Query: 123 KEVRLLLLTNGDRQTQREKIEAC--ACQSYF--DAVVVGGEQREEKPAPSIFYYCCNLLG 178 E ++ G Q +E F + +V + + KP P + G Sbjct: 123 SEGLTPMVVTGS--GQLSLLERLEHNFPGMFHKELMVTAFDVKYGKPNPEPYLMALKKGG 180 Query: 179 VQPGDCVMVGDTLETDIQGGLNAGLKATVWIN 210 ++ + V++ + ++ G AG+ Sbjct: 181 LKADEAVVIENAP-LGVEAGHKAGIFTIAVNT 211 >1PW5-A nrPDB Length = 253 Score = 51.4 bits (121), Expect = 4e-07, Method: Composition-based stats. Identities = 39/228 (17%), Positives = 73/228 (32%), Gaps = 20/228 (8%) Query: 3 LSRVRAVFFDLDNT--LIDTAGASRRGMLEVIKLLQSKYHY--------KEEAEIICDKV 52 L ++ D+D T L D+ LE +K ++ + ++ + Sbjct: 2 LDKIELFILDMDGTFYLDDSLLPGSLEFLETLKEKNKRFVFFTNNSSLGAQDYVRKLRNM 61 Query: 53 QVKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAE 112 V + + + + G +K+ E + + L Sbjct: 62 GVDVPDDAVVTSGEITAEHMLKRFGRCRIFLLGTPQLKKVFEAYGHVIDEENPDFVVLGF 121 Query: 113 DVKAMLTELRKEVRLL------LLTNGDRQTQREKIEACACQSYFDAVVVGGEQR----E 162 D L+K LL + T+ D ++ S A+ ++ Sbjct: 122 DKTLTYERLKKACILLRKGKFYIATHPDINCPSKEGPVPDAGSIMAAIEASTGRKPDLIA 181 Query: 163 EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWIN 210 KP P + GV MVGD L TD++ G NAG+ + + + Sbjct: 182 GKPNPLVVDVISEKFGVPKERMAMVGDRLYTDVKLGKNAGIVSILVLT 229 >3PDW-A nrPDB Length = 266 Score = 50.2 bits (118), Expect = 8e-07, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 66/229 (28%), Gaps = 19/229 (8%) Query: 1 MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHY-------KEEAEIICDKVQ 53 M L + DLD T+ + V L Y + + DK+ Sbjct: 1 MSLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLV 60 Query: 54 ---VKLSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTL 110 + ++E + ++A G R+ EE + + + Sbjct: 61 SFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENADFVVV 120 Query: 111 AEDVKAMLTELR------KEVRLLLLTNGDRQTQREKIEACA---CQSYFDAVVVGGEQR 161 D + + + TNGD E+ S Sbjct: 121 GIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVF 180 Query: 162 EEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWIN 210 KP I +LG + +MVGD TDI G+NAG+ + Sbjct: 181 IGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHT 229 >3NUQ-A nrPDB Length = 282 Score = 48.3 bits (113), Expect = 3e-06, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 89/246 (36%), Gaps = 32/246 (13%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 ++ FFD+DN L ++ M + I + +KLS E H N Sbjct: 57 LKVFFFDIDNCLYKSSTRIHDLMQQSILRFF--------------QTHLKLSPEDAHVLN 102 Query: 66 TCITDLRTSHWEEAIQETKGGAA-NRKLAEECYFLWKSTRLQHMTLAEDVK--AMLTELR 122 S+++E +G ++ A E L + L D+ ML LR Sbjct: 103 -------NSYYKEYGLAIRGLVMFHKVNALEYNRLVDDSLPLQDILKPDIPLRNMLLRLR 155 Query: 123 KEVR---LLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREE----KPAPSIFYYCCN 175 + + L L TN + + FD + R + KP F Sbjct: 156 QSGKIDKLWLFTNAYKNHAIRCLRLLGIADLFDGLTYCDYSRTDTLVCKPHVKAFEKAMK 215 Query: 176 LLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVP-LKSSPVPHYMVSSVLELP 234 G+ + D +I+ G+ G+K + + +N + L +P ++S +LELP Sbjct: 216 ESGLARYENAYFIDDSGKNIETGIKLGMKTCIHLVENEVNEILGQTPEGAIVISDILELP 275 Query: 235 ALLQSI 240 ++ + Sbjct: 276 HVVSDL 281 >4Y2Y-A nrPDB Length = 561 Score = 46.8 bits (109), Expect = 9e-06, Method: Composition-based stats. Identities = 39/243 (16%), Positives = 85/243 (34%), Gaps = 30/243 (12%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +RA FDLD L A G + E + + + + + P Sbjct: 3 LRAAVFDLDGVLALPAVFGVLG--------------RTEEALALPRGLLNDAFQKGGPEG 48 Query: 66 TCITDLRT----SHW----EEAIQETKGGAANRKLAEEC--YFLWKSTRLQHMTLAEDVK 115 ++ S W EE ++ A L + ++ ++ Sbjct: 49 ATTRLMKGEITLSQWIPLMEENCRKCSETA-KVCLPKNFSIKEIFDKAISARKINRPMLQ 107 Query: 116 AMLTELRKEVRLLLLTNG--DRQTQREKIEACACQ--SYFDAVVVGGEQREEKPAPSIFY 171 A L +K +LTN D + +R+ + C+ +FD ++ + KP P I+ Sbjct: 108 AALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYK 167 Query: 172 YCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVL 231 + + L P + V + D + +++ + G+ + + + + ++++ Sbjct: 168 FLLDTLKASPSEVVFLDD-IGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPA 226 Query: 232 ELP 234 LP Sbjct: 227 PLP 229 >4PNH-A nrPDB Length = 199 Score = 45.2 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVP 223 KP P + + P D +VGD+L D+Q G G + + + G L + +P Sbjct: 119 KPMPGMMKLIAERFEIDPADTPVVGDSLR-DLQAGAALGFRPHLVLTGKGKKTLAAGGLP 177 Query: 224 H 224 Sbjct: 178 E 178 >2B0C-A nrPDB Length = 206 Score = 44.5 bits (103), Expect = 4e-05, Method: Composition-based stats. Identities = 42/223 (18%), Positives = 77/223 (34%), Gaps = 38/223 (17%) Query: 10 FFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYNTCIT 69 FDL N ++D G + ++ + K+ FH Sbjct: 11 IFDLGNVIVDIDFNRVLGAWSDLT-----------------RIPLASLKKSFHMGEAFHQ 53 Query: 70 DLRTSHWEEAIQETK-GGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV-RL 127 R +EA E A E+ W++ + L +V A++ +LR++ R+ Sbjct: 54 HERGEISDEAFAEALCHEMALPLSYEQFSHGWQAV---FVALRPEVIAIMHKLREQGHRV 110 Query: 128 LLLTNGDRQT----QREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD 183 ++L+N +R E E D + + + KP I+ + G P D Sbjct: 111 VVLSNTNRLHTTFWPEEYPEIRDAA---DHIYLSQDLGMRKPEARIYQHVLQAEGFSPSD 167 Query: 184 CVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYM 226 V D + I+G G+ + + +K +P Y Sbjct: 168 TVFFDDNADN-IEGANQLGITSILVKDKT--------TIPDYF 201 >1CR6-A nrPDB Length = 554 Score = 43.3 bits (100), Expect = 9e-05, Method: Composition-based stats. Identities = 35/234 (14%), Positives = 81/234 (34%), Gaps = 12/234 (5%) Query: 6 VRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPYN 65 +R FDLD L + A E L + + +L K ++ Sbjct: 3 LRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKI-TFS 61 Query: 66 TCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKEV 125 + + S+ + + N +++ + + L +A + +K Sbjct: 62 QWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPML----QAAIALKKKGF 117 Query: 126 RLLLLTN-----GDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ 180 ++TN GD++ ++ C +FD ++ + KP P I+ + + L + Sbjct: 118 TTCIVTNNWLDDGDKRDSLAQM-MCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAK 176 Query: 181 PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELP 234 P + V + D ++++ + G+ + N + + L +P Sbjct: 177 PNEVVFLDD-FGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVP 229 >4JB3-A nrPDB Length = 228 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 38/209 (18%), Positives = 67/209 (32%), Gaps = 28/209 (13%) Query: 4 SRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHP 63 S ++ + FD ++D + L +A+ DK +H Sbjct: 22 SMIKNIVFDFGGVIVDIDRDKAVQAFIKLGL--------ADADTRLDK---------YHQ 64 Query: 64 YNTCITDLRTSHWEEAIQETKGGAANRKLA-EECYFLWKSTRLQHMTLAEDVKAMLTELR 122 + ++ G R+L EE W + + +L LR Sbjct: 65 TGIFQELEEGKLSADEFRKQLGDLCGRELTMEETKQAWLGFFNE--VDLRKLDYIL-GLR 121 Query: 123 KEVRLLLLTNGD------RQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNL 176 K + LL+N + + E Y D + + + KPAP IF + Sbjct: 122 KSYHVYLLSNTNPFVMSWACSPEFSSEGKPLNDYCDKLYLSYQLGHTKPAPEIFDFMIKD 181 Query: 177 LGVQPGDCVMVGDTLETDIQGGLNAGLKA 205 V P + + V D ++I G G + Sbjct: 182 SHVIPSETLFVDD-GSSNIHIGKELGFET 209 >3L8F-A nrPDB Length = 187 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 60/162 (37%), Gaps = 27/162 (16%) Query: 103 TRLQHMTLAEDVKAMLTELRK-EVRLLLLTNGD-------RQTQREKIEACACQSYFDAV 154 + + + V + EL+K L+++TN + Q E + S D Sbjct: 24 HEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLADRD 83 Query: 155 VVGG--------------EQRE----EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQ 196 V E R+ KP P + + L + MVGD LE D+Q Sbjct: 84 VDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLE-DMQ 142 Query: 197 GGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQ 238 + A + V + + ++ ++++S+ +LP ++ Sbjct: 143 AAVAANVGTKVLVRTGKPITPEAENAADWVLNSLADLPQAIK 184 >3L1U-A nrPDB Length = 211 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 60/162 (37%), Gaps = 27/162 (16%) Query: 103 TRLQHMTLAEDVKAMLTELRK-EVRLLLLTNGD-------RQTQREKIEACACQSYFDAV 154 + + + V + EL+K L+++TN + Q E + S D Sbjct: 44 HEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLADRD 103 Query: 155 VVGG--------------EQRE----EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQ 196 V E R+ KP P + + L + MVGD LE D+Q Sbjct: 104 VDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLE-DMQ 162 Query: 197 GGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQ 238 + A + V + + ++ ++++S+ +LP ++ Sbjct: 163 AAVAANVGTKVLVRTGKPITPEAENAADWVLNSLADLPQAIK 204 >2O2X-A nrPDB Length = 218 Score = 40.6 bits (93), Expect = 7e-04, Method: Composition-based stats. Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 4/94 (4%) Query: 150 YFDAVVVGGEQRE---EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKAT 206 Y +A V + KP P + L + ++VGD L D+Q G AGL Sbjct: 120 YHEAGVGPLAIPDHPMRKPNPGMLVEAGKRLALDLQRSLIVGDKL-ADMQAGKRAGLAQG 178 Query: 207 VWINKNGIVPLKSSPVPHYMVSSVLELPALLQSI 240 ++ V + P S + +L A ++++ Sbjct: 179 WLVDGEAAVQPGFAIRPLRDSSELGDLLAAIETL 212 >4I9G-A nrPDB Length = 361 Score = 38.3 bits (87), Expect = 0.003, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 38/101 (37%), Gaps = 6/101 (5%) Query: 113 DVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAV---VVGGEQREEKPAPSI 169 D+ +R L + N D E+ S A+ + KPAP++ Sbjct: 141 DLAEAALAIRAGA-LWVAANVDPTLPTERGLLPGNGSMVAALRTATGMDPRVAGKPAPAL 199 Query: 170 FYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWIN 210 ++VGD L+TDI+G AGL + + + Sbjct: 200 MTEAVAR--GDFRAALVVGDRLDTDIEGANAAGLPSLMVLT 238 >2HO4-A nrPDB Length = 259 Score = 36.8 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 84/253 (33%), Gaps = 42/253 (16%) Query: 6 VRAVFFDLDNTL--IDTAGASRRGMLEVIKLLQSKYHY--------KEEAEIICDKVQVK 55 ++AV DL+ TL D A + L+ ++ + K++ K++ + Sbjct: 7 LKAVLVDLNGTLHIEDAAVPGAQEALKRLRATSVMVRFVTNTTKETKKDLLERLKKLEFE 66 Query: 56 LSKECFHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVK 115 +S++ T +T R ++ ++ +R L E F T+ + + Sbjct: 67 ISEDEIF---TSLTAARNLIEQKQVRPML-LLDDRALPE---FTGVQTQDPNAVVIGLAP 119 Query: 116 AML--TELRKEVRLLL---------------LTNGDRQTQREKIEACACQSYFDAVVVGG 158 L + RLLL +G + A + A+VVG Sbjct: 120 EHFHYQLLNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKAMVVG- 178 Query: 159 EQREEKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLK 218 KP + F P + VM+GD D+ G N G+ + + Sbjct: 179 -----KPEKTFFLEALRDADCAPEEAVMIGDDCRDDVDGAQNIGMLGILVKTGKYKAADE 233 Query: 219 SS--PVPHYMVSS 229 P P+ S Sbjct: 234 EKINPPPYLTCES 246 >3L8H-A nrPDB Length = 179 Score = 36.4 bits (82), Expect = 0.011, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 22/61 (36%), Gaps = 1/61 (1%) Query: 164 KPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVP 223 KP P ++ V VGD+L D+Q AG + NG L +P Sbjct: 101 KPLPGMYRDIARRYDVDLAGVPAVGDSLR-DLQAAAQAGCAPWLVQTGNGRKTLAQGGLP 159 Query: 224 H 224 Sbjct: 160 E 160 >1U7O-A nrPDB Length = 164 Score = 36.0 bits (81), Expect = 0.015, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 33/102 (32%), Gaps = 11/102 (10%) Query: 101 KSTRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDR--QTQREKIEACACQSYFDAVVVGG 158 + R Q++ L +V +L L+ + + Q + +E YF Sbjct: 38 RDRRGQNIQLYPEVPEVLGRLQSLGVPVAAASRTSEIQGANQLLELFDLGKYFI------ 91 Query: 159 EQREEKPAPSI--FYYCCNLLGVQPGDCVMVGDTLETDIQGG 198 QRE P + F + GV V D I G Sbjct: 92 -QREIYPGSKVTHFERLHHKTGVPFSQMVFFDDENRNIIDVG 132 >3HLT-A nrPDB Length = 266 Score = 36.0 bits (81), Expect = 0.016, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 25/69 (36%), Gaps = 2/69 (2%) Query: 163 EKPAPSIFYYCCNLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSS-- 220 KP + F G +P + VM+GD D+ G + G+ + + Sbjct: 178 GKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKIN 237 Query: 221 PVPHYMVSS 229 P P+ S Sbjct: 238 PPPYLTCES 246 >2QLT-A nrPDB Length = 275 Score = 35.2 bits (79), Expect = 0.030, Method: Composition-based stats. Identities = 35/194 (18%), Positives = 65/194 (33%), Gaps = 34/194 (17%) Query: 5 RVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFHPY 64 ++ A FD+D T+I + A + K K ++ E + + + Sbjct: 34 KINAALFDVDGTIIISQPAIAAFWRDFGK---DKPYFDAE-----HVIHISHGWRTYDAI 85 Query: 65 NTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELRKE 124 D EE + + G K E + + +L + L L KE Sbjct: 86 AKFAPDFAD---EEYVNK-LEGEIPEKYGEHSIEVPGAVKLCNA---------LNALPKE 132 Query: 125 VRLLLLTNGDRQTQREKIEACACQS--YFDAVVVGGEQREEKPAPSIFYYCCNLLGV--- 179 + + T+G R ++ + + YF + + ++ KP P + N LG Sbjct: 133 -KWAVATSGTRDMAKKWFDILKIKRPEYF---ITANDVKQGKPHPEPYLKGRNGLGFPIN 188 Query: 180 --QP--GDCVMVGD 189 P V+ D Sbjct: 189 EQDPSKSKVVVFED 202 >5YA1-A nrPDB Length = 540 Score = 32.9 bits (73), Expect = 0.14, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 20/49 (40%) Query: 2 GLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICD 50 G +RAV FDL+ I A R + ++ + ++ C+ Sbjct: 30 GTGSIRAVIFDLEGNQIAVGQAEWRHLAVPDVPGSMEFDLNKNWQLACE 78 >3IRU-A nrPDB Length = 277 Score = 32.1 bits (71), Expect = 0.21, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 67/202 (33%), Gaps = 33/202 (16%) Query: 71 LRTSHWEEAIQETKGGAANRKLAEECYFLW----KSTRLQHMTLAEDVKAMLTELRKEVR 126 L S A KG A+N + + Y L+ Q L K + +L + Sbjct: 69 LGNSRIANAWLSIKGQASNEEDIKRLYDLFAPIQTRIVAQRSQLIPGWKEVFDKLIAQGI 128 Query: 127 LLLLTNGDRQTQR-EKIEACACQSYFDA-VVVGGEQREEKPAPSIFYYCCNLLGV-QPGD 183 + G + A Q Y A V + +P P + L V Sbjct: 129 KVGGNTGYGPGMMAPALIAAKEQGYTPASTVFATDVVRGRPFPDMALKVALELEVGHVNG 188 Query: 184 CVMVGDTLETDIQGGLNAGLKATVWINKNG-----------IVPLKSSPV---------- 222 C+ V DTL I+ GL AG+ TV ++ +G + Sbjct: 189 CIKVDDTL-PGIEEGLRAGM-WTVGVSCSGNEVGLDREDWQALSSDEQQSYRQHAEQRLF 246 Query: 223 ---PHYMVSSVLELPALLQSID 241 HY++ SV +L ++ ++ Sbjct: 247 NAGAHYVIDSVADLETVITDVN 268 >6GRI-C nrPDB Length = 272 Score = 30.2 bits (66), Expect = 0.91, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 27/82 (32%), Gaps = 7/82 (8%) Query: 134 DRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQPGD------CVM- 186 E + C QS + ++ G +R KP ++ Y + +M Sbjct: 154 PLSQALEPVATCNTQSLYRSLSGGDSERLGKPHFALVYCIIFEKALFKYRYRGYRMALME 213 Query: 187 VGDTLETDIQGGLNAGLKATVW 208 G + + GLK VW Sbjct: 214 TGSMYQNAVLVADQIGLKNRVW 235 >2WM8-A nrPDB Length = 187 Score = 29.8 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 27/97 (27%), Gaps = 11/97 (11%) Query: 101 KSTRLQHMTLAEDVKAMLTELRKEVRLLLLTNGDR--QTQREKIEACACQSYFDAVVVGG 158 + R Q + L +V +L L+ + + + +E YF Sbjct: 60 RDRRGQDVRLYPEVPEVLKRLQSLGVPGAAASRTSEIEGANQLLELFDLFRYFV------ 113 Query: 159 EQREEKPAPSI--FYYCCNLLGVQPGDCVMVGDTLET 193 RE P I F G+ + D Sbjct: 114 -HREIYPGSKITHFERLQQKTGIPFSQMIFFDDERRN 149 >1PZ1-A nrPDB Length = 333 Score = 29.4 bits (64), Expect = 1.5, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 46/125 (36%), Gaps = 12/125 (9%) Query: 3 LSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKECFH 62 + +RA D TLIDTA A G E I K + K + I+ K + Sbjct: 37 IETIRAAL-DQGITLIDTAPAYGFGQSEEIVGKAIKEYMKRDQVILATKTALDWKNNQLF 95 Query: 63 PYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTELR 122 R ++ ++E + ++L + L++ + E+ ++ EL Sbjct: 96 ---------RHANRARIVEEVENSL--KRLQTDYIDLYQVHWPDPLVPIEETAEVMKELY 144 Query: 123 KEVRL 127 ++ Sbjct: 145 DAGKI 149 >3WDH-A nrPDB Length = 710 Score = 27.9 bits (60), Expect = 4.0, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 23/67 (34%), Gaps = 2/67 (2%) Query: 54 VKLSKECFH-PYNTCITDLRTSH-WEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLA 111 K + ++ P D WEE ++E RK FL +HM Sbjct: 576 KKGVENSYNSPDEVNQVDWNEKSRWEEDVREIMKLIELRKKHGAFRFLTADQVRRHMKFY 635 Query: 112 EDVKAML 118 + +++ Sbjct: 636 DTHPSVI 642 >5MSN-A nrPDB Length = 293 Score = 27.9 bits (60), Expect = 4.1, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 6/71 (8%) Query: 61 FHPYNTCITDLRTSHW---EEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAM 117 F P + I LR H+ ++ +Q E L++ LQ ED+K + Sbjct: 204 FFPCDIDIDMLRGYHFKPTDKTVQYIAKSTLPMDPKERFKVLFR---LQSQWDLEDIKPL 260 Query: 118 LTELRKEVRLL 128 + EL + Sbjct: 261 IEELNSRGMKI 271 >5OKI-C nrPDB Length = 380 Score = 27.5 bits (59), Expect = 4.9, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 6/71 (8%) Query: 61 FHPYNTCITDLRTSHW---EEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAM 117 F P + I LR H+ ++ +Q E L++ LQ ED+K + Sbjct: 291 FFPCDIDIDMLRGYHFKPTDKTVQYIAKSTLPMDPKERFKVLFR---LQSQWDLEDIKPL 347 Query: 118 LTELRKEVRLL 128 + EL + Sbjct: 348 IEELNSRGMKI 358 >2LEF-A nrPDB Length = 86 Score = 27.1 bits (58), Expect = 7.7, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 14/37 (37%), Gaps = 3/37 (8%) Query: 79 AIQETKGGAANRKLAEE---CYFLWKSTRLQHMTLAE 112 AI + G + EE Y L + R HM L Sbjct: 32 AINQILGRRWHALSREEQAKYYELARKERQLHMQLYP 68 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.118 0.280 Lambda K H 0.267 0.0358 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 7,314,678 Number of Sequences: 36641 Number of extensions: 241281 Number of successful extensions: 867 Number of sequences better than 10.0: 49 Number of HSP's better than 10.0 without gapping: 57 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 766 Number of HSP's gapped (non-prelim): 92 length of query: 248 length of database: 10,336,785 effective HSP length: 95 effective length of query: 153 effective length of database: 6,855,890 effective search space: 1048951170 effective search space used: 1048951170 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 57 (26.8 bits)