BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q8N5Z0 (425 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4GDY-A nrPDB 873 0.0 6HNB-A nrPDB 238 3e-63 4JE5-A nrPDB 201 4e-52 3AV7-A nrPDB 199 1e-51 1X0M-A nrPDB 199 1e-51 1WST-A nrPDB 187 5e-48 2ZC0-A nrPDB 177 1e-44 2ZYJ-A nrPDB 161 5e-40 6HNV-A nrPDB 154 8e-38 1VP4-A nrPDB 153 1e-37 1GC4-A nrPDB 93 2e-19 1V2E-A nrPDB 83 2e-16 1GDE-A nrPDB 79 5e-15 2O1B-A nrPDB 72 4e-13 5WMH-A nrPDB 65 4e-11 1J32-A nrPDB 63 2e-10 3OP7-A nrPDB 62 5e-10 1O4S-A nrPDB 60 1e-09 2X5D-A nrPDB 60 2e-09 4N0B-A nrPDB 59 3e-09 5X03-B nrPDB 59 3e-09 4MY5-A nrPDB 59 5e-09 3IF2-A nrPDB 58 9e-09 6F77-B nrPDB 57 1e-08 3EZ1-A nrPDB 57 1e-08 3G7Q-A nrPDB 57 1e-08 6F35-A nrPDB 56 3e-08 1U08-A nrPDB 55 5e-08 5YHV-A nrPDB 55 7e-08 2GB3-A nrPDB 54 9e-08 3B46-A nrPDB 54 9e-08 3H14-A nrPDB 54 1e-07 4CVQ-A nrPDB 50 2e-06 2DOU-A nrPDB 50 2e-06 5IWQ-A nrPDB 49 3e-06 1XI9-A nrPDB 49 3e-06 3JTX-A nrPDB 49 4e-06 2O0R-A nrPDB 48 8e-06 3FVS-A nrPDB 47 2e-05 4WP0-A nrPDB 47 2e-05 3NRA-A nrPDB 46 4e-05 3DYD-A nrPDB 44 1e-04 4M2J-A nrPDB 44 2e-04 2ZJG-A nrPDB 43 2e-04 2Z61-A nrPDB 43 3e-04 3PDX-A nrPDB 42 5e-04 3G0T-A nrPDB 40 0.002 3DZZ-A nrPDB 39 0.004 3EZS-A nrPDB 37 0.013 4IX8-A nrPDB 37 0.014 3QGU-A nrPDB 36 0.039 3EI8-A nrPDB 35 0.076 5GKO-A nrPDB 33 0.30 3P1T-A nrPDB 33 0.31 3TCM-A nrPDB 32 0.35 3ASB-A nrPDB 32 0.40 1UU1-A nrPDB 31 1.0 5LJ6-A nrPDB 30 1.3 3NNK-A nrPDB 30 2.3 5XTI-AF nrPDB 29 3.0 3EUC-A nrPDB 29 3.8 3MEB-A nrPDB 29 4.9 5X5H-A nrPDB 28 5.7 3K53-A nrPDB 28 6.5 5W1B-A nrPDB 28 6.7 3QV0-A nrPDB 28 7.7 1BCC-F nrPDB 28 8.9 1M4N-A nrPDB 28 9.2 >4GDY-A nrPDB Length = 439 Score = 873 bits (2256), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/425 (99%), Positives = 423/425 (99%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT Sbjct: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG Sbjct: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP Sbjct: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN Sbjct: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNS 240 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ Sbjct: 241 GRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV Sbjct: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 Query: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL Sbjct: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 Query: 421 IKESL 425 IKESL Sbjct: 421 IKESL 425 >6HNB-A nrPDB Length = 491 Score = 238 bits (608), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 145/493 (29%), Positives = 251/493 (50%), Gaps = 89/493 (18%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKT----------- 50 + ++ S AR SP++ + + + L GGLP + FPF+ Sbjct: 11 DLTHLLSNESKARQTSPLKGIFKYYKQ--PGITFLGGGLPLSDYFPFEKVTADIPTPSFS 68 Query: 51 ----AVITVENGKTIQFGEEM---------MKRALQYSPSAGIPELLSWLKQLQIKLHNP 97 A I EN TI+ ++ + R+LQY + G+PE L ++K+ +H Sbjct: 69 GGIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEHTDMVHKV 128 Query: 98 PTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNII 157 P ++ D+ V+ G+ + + GD +L++E +S L+S + G N + Sbjct: 129 PYENW-------DVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESANGQGVNTV 181 Query: 158 NVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIY 217 V DE GI+P+ L +++SRW N PKFLYT+ G NPTG+SL++ER+K+IY Sbjct: 182 PVTMDEFGIIPEKLEELMSRW--------VGNKPKFLYTICTGQNPTGSSLSAERRKQIY 233 Query: 218 ELARKYDFLIIEDDPYYFLQ---------------------FNKFRVPTFLSMDVDGRVI 256 ++A KYDFLIIED+PYYFLQ F K VP+F+S+DV+GRV+ Sbjct: 234 DIACKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVV 293 Query: 257 RADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFM 316 R DSFSK+++ GLR+G++ G K L+ER + +VS +PS F++ + + LL +WG G++ Sbjct: 294 RLDSFSKVLAPGLRLGWIVGQKDLLERYVRLHEVSVQNPSGFSEALANALLRKWGHSGYL 353 Query: 317 AHVDRVIDFYSNQKDAILAAADKWL-TGLAEWHVPAAGMFLWIKVKGIN----------- 364 + + Y++++D + A D+++ ++ ++ P AGMF + + Sbjct: 354 DWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEFLEDP 413 Query: 365 -DVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP--------------YLRASFSSASPEQ 409 V+ + E+A+K G L+ PG+ F + + P + R ++++ +Q Sbjct: 414 LKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQ 473 Query: 410 MDVAFQVLAQLIK 422 + V + + ++ Sbjct: 474 LVVGLEKFGKAVR 486 >4JE5-A nrPDB Length = 503 Score = 201 bits (512), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 138/504 (27%), Positives = 237/504 (47%), Gaps = 95/504 (18%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVIT------- 54 +++ + + AR PSP++T + ++I L GGLP + FP+ + Sbjct: 11 DFSYLFSDETNARKPSPLKTCIHLFQD--PNIIFLGGGLPLKDYFPWDNLSVDSPKPPFP 68 Query: 55 ------VENGKTIQF--------------GEEMMKRALQYSPSAGIPELLSWLKQLQIKL 94 ++ I++ + + RALQY SAG PELL++++ + Sbjct: 69 QGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKII 128 Query: 95 HNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGC 154 H+ + Y D+ T+G+ + N GD +L++ ++S +L S G Sbjct: 129 HD---LKY----KDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGV 181 Query: 155 NIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKK 214 V D GI+P+ L ++ W P K PK LYT+P G NPTG S+ RK+ Sbjct: 182 ITFPVPIDADGIIPEKLAKVMENWTPGAPK------PKLLYTIPTGQNPTGTSIADHRKE 235 Query: 215 EIYELARKYDFLIIEDDPYYFLQFN------------------------KFRVPTFLSMD 250 IY++A+KYDFLI+ED+PYYFLQ N K TFLS+D Sbjct: 236 AIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLD 295 Query: 251 VDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 +GRVIR DSFSK+++ G R+G++TG +++ + +++ P+ F Q++++ L W Sbjct: 296 TEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRW 355 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV--PAAGMFLWI---------- 358 G++G++ + + Y+ ++D + A K+L + + P AGMF + Sbjct: 356 GQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEF 415 Query: 359 KVKGINDVKEL---IEEKAVKMGVLMLPGNAFYVDSSAPSP--------------YLRAS 401 K K +D +L + K V+ GVL++PG+ F + P + R + Sbjct: 416 KTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGT 475 Query: 402 FSSASPEQMDVAFQVLAQLIKESL 425 +++ SPE++ + L + E Sbjct: 476 YAAVSPEKLTEGLKRLGDTLYEEF 499 >3AV7-A nrPDB Length = 448 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 128/426 (30%), Positives = 222/426 (52%), Gaps = 36/426 (8%) Query: 5 RFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFG 64 RF + + S +R + ++ +ISLAGGLPNP FP K + + ++ Sbjct: 52 RFFSKKALEMRASEVRELLKLVE--TSDIISLAGGLPNPKTFP-KEIIRDI----LVEIM 104 Query: 65 EEMMKRALQYSPSAGI----PELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 E+ +ALQY + G L+ WL + Y SQ D+ +TSGSQQ Sbjct: 105 EKYADKALQYGTTKGFTPLRETLMKWLGK-----------RYGISQDN-DIMITSGSQQA 152 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L + + +NPGD V+++ P Y LQ+ + I + D+ G+ + L + L K Sbjct: 153 LDLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDEGMKVEILEEKLKELKS 212 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 + K K +YTVP NP G ++ +R+K + ELA +YDF+++EDDPY L+++ Sbjct: 213 QGKK------VKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSG 266 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 ++D +GRVI +FSKI++ G RIG++ G +I ++ + Q + L + F Q Sbjct: 267 NPEKKIKALDNEGRVIYLGTFSKILAPGFRIGWMVGDPGIIRKMEIAKQSTDLCTNVFGQ 326 Query: 301 LMISQLLHEWGEEGFM-AHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIK 359 ++ + + + G++ H+ + FY ++DA+L A ++++ +W P GMF+W+ Sbjct: 327 VVAWRYV----DGGYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVT 382 Query: 360 VKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQ 419 + D K+++ E+A+K GV +PG AFY + +R +F+ +++ + LA+ Sbjct: 383 LPDGIDSKKML-ERAIKKGVAYVPGEAFYAHRDVKNT-MRLNFTYVDEDKIMEGIKRLAE 440 Query: 420 LIKESL 425 IKE L Sbjct: 441 TIKEEL 446 >1X0M-A nrPDB Length = 403 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 128/426 (30%), Positives = 222/426 (52%), Gaps = 36/426 (8%) Query: 5 RFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFG 64 RF + + S +R + ++ +ISLAGGLPNP FP K + + ++ Sbjct: 7 RFFSKKALEMRASEVRELLKLVE--TSDIISLAGGLPNPKTFP-KEIIRDI----LVEIM 59 Query: 65 EEMMKRALQYSPSAGI----PELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 E+ +ALQY + G L+ WL + Y SQ D+ +TSGSQQ Sbjct: 60 EKYADKALQYGTTKGFTPLRETLMKWLGK-----------RYGISQDN-DIMITSGSQQA 107 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L + + +NPGD V+++ P Y LQ+ + I + D+ G+ + L + L K Sbjct: 108 LDLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDEGMKVEILEEKLKELKS 167 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 + K K +YTVP NP G ++ +R+K + ELA +YDF+++EDDPY L+++ Sbjct: 168 QGKK------VKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSG 221 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 ++D +GRVI +FSKI++ G RIG++ G +I ++ + Q + L + F Q Sbjct: 222 NPEKKIKALDNEGRVIYLGTFSKILAPGFRIGWMVGDPGIIRKMEIAKQSTDLCTNVFGQ 281 Query: 301 LMISQLLHEWGEEGFM-AHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIK 359 ++ + + + G++ H+ + FY ++DA+L A ++++ +W P GMF+W+ Sbjct: 282 VVAWRYV----DGGYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVT 337 Query: 360 VKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQ 419 + D K+++ E+A+K GV +PG AFY + +R +F+ +++ + LA+ Sbjct: 338 LPDGIDSKKML-ERAIKKGVAYVPGEAFYAHRDVKNT-MRLNFTYVDEDKIMEGIKRLAE 395 Query: 420 LIKESL 425 IKE L Sbjct: 396 TIKEEL 401 >1WST-A nrPDB Length = 417 Score = 187 bits (476), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 126/426 (29%), Positives = 216/426 (50%), Gaps = 27/426 (6%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 +N+ F + + S +R + ++ +ISLAGGLP P FP +T Sbjct: 13 INFDSFFSEKAMLMKASEVRELLKLVETS--DVISLAGGLPAPETFPVETI-----KKIA 65 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 ++ EE +ALQY + G L L + K ++ P ++++ +GSQQ Sbjct: 66 VEVLEEHADKALQYGTTKGFTPLRLALARWMEKRYDIP-------MSKVEIMTVAGSQQA 118 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L + + +NPGD ++++ P Y +Q+ I++ D+ G+ D L + L + Sbjct: 119 LDLIGRVFLNPGDPIVVEAPTYLAAIQAFKYYDPEFISIPLDDKGMRVDLLEEKLEELRK 178 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 Q K +YTV NP G +++ +R+K++ ELA +YDFLI+ED PY L+++ Sbjct: 179 ------QGKRVKIVYTVSTFQNPAGVTMSVDRRKKLLELANEYDFLIVEDGPYSELRYSG 232 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 P D GRVI +FSKI++ G RIG++ LI ++ + Q L +TF Q Sbjct: 233 EPTPPIKHFDDYGRVIYLGTFSKILAPGFRIGWVAAHPHLIRKMEIAKQSIDLCTNTFGQ 292 Query: 301 LMISQLLHEWGEEGFM-AHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIK 359 + ++ E G++ H+ ++I+FY ++DA+L A ++++ EW P GMF+ + Sbjct: 293 ----AIAWKYVENGYLDEHIPKIIEFYKPRRDAMLEALEEYMPEGVEWTKPEGGMFVRVT 348 Query: 360 VKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQ 419 + D K L+ E+AV GV +PG AF+V + +R +F+ E + + LA+ Sbjct: 349 LPEGIDTK-LMMERAVAKGVAYVPGEAFFVHRDKKNT-MRLNFTYVPEETIREGVRRLAE 406 Query: 420 LIKESL 425 IKE + Sbjct: 407 TIKEEM 412 >2ZC0-A nrPDB Length = 407 Score = 177 bits (448), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 129/436 (29%), Positives = 222/436 (50%), Gaps = 42/436 (9%) Query: 1 MNYARFITAASAARNPSPI----RTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVE 56 M+Y +++ + S + + +++ +G K +ISLA G P+P + P AV+ Sbjct: 1 MDYTKYLAGRANWIKGSALADVMKKASELQKKGVK-LISLAAGDPDPELIP--RAVL--- 54 Query: 57 NGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 G+ + E +++ Y+P+ GIPEL L K + + P ++ +T G Sbjct: 55 -GEIAKEVLEKEPKSVMYTPANGIPELREELAAFLKKYDH---LEVSPE----NIVITIG 106 Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 L + ++I+PGD V+ + P+Y TL + LG I V D G+ D L + + Sbjct: 107 GTGALDLLGRVLIDPGDVVITENPSYINTLLAFEQLGAKIEGVPVDNDGMRVDLLEEKIK 166 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 K + K K +YT+P G NP G +++ ER+K + E+A KYD LIIED Y F+ Sbjct: 167 ELKAKGQK------VKLIYTIPTGQNPMGVTMSMERRKALLEIASKYDLLIIEDTAYNFM 220 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 ++ + ++D +GRVI A + SK++ +G RIG++ ++++V++ Q P Sbjct: 221 RYEGGDIVPLKALDNEGRVIVAGTLSKVLGTGFRIGWIIAEGEILKKVLMQKQ-----PI 275 Query: 297 TFNQLMISQLLH-EWGEEGFMA--HVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAG 353 F ISQ + E+ + G+ H++ + Y ++D +L A + L AE+ P AG Sbjct: 276 DFCAPAISQYIALEYLKRGYFEKYHLEGALLGYKEKRDIMLKALENHLPN-AEFTKPIAG 334 Query: 354 MFLWI----KVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQ 409 MF+ GI+ EL+E + GV+++PG FY D S + +R +FS S E+ Sbjct: 335 MFVMFFLPEGADGISFANELMERE----GVVVVPGKPFYTDESGKNA-IRLNFSRPSKEE 389 Query: 410 MDVAFQVLAQLIKESL 425 + + + LA+L KE Sbjct: 390 IPIGIKKLAKLYKEKF 405 >2ZYJ-A nrPDB Length = 397 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 115/415 (27%), Positives = 202/415 (48%), Gaps = 52/415 (12%) Query: 17 SPIRTMTDILSRGPKSMISLAGGLPNPNMFP-----FKTAVITVENGKTIQFGEEMMKRA 71 S IR + + R ++S AGGLP P +FP A I E G+ A Sbjct: 20 STIRELLKLTQR--PGILSFAGGLPAPELFPKEEAAEAAARILREKGEV----------A 67 Query: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 LQYSP+ G L +++ + I P ++ +T+GSQQ L V ++ ++ Sbjct: 68 LQYSPTEGYAPLRAFVAEW---------IGVRPE----EVLITTGSQQALDLVGKVFLDE 114 Query: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 G VLL+ P+Y G +Q+ G + V + E G D+L ++L R + P Sbjct: 115 GSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDALEEVLKRER-----------P 163 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV 251 +FLY +P+ NPTG +K + ++ + +++EDD Y L F + R+P+ + Sbjct: 164 RFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDAYRELYFGEARLPSLFELAR 223 Query: 252 DG---RVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLH 308 + VI SFSK++S GLR+ F +++++ Q + LH NQ+++ +LL Sbjct: 224 EAGYPGVIYLGSFSKVLSPGLRVAFAVAHPEALQKLVQAKQGADLHTPMLNQMLVHELL- 282 Query: 309 EWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV-KGINDVK 367 +EGF ++RV Y + A+L A D+ + + P GMF+W+++ KG++ Sbjct: 283 ---KEGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVWMELPKGLS--A 337 Query: 368 ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 E + +A++ V +PG F+ + + LR S+++ E + + L + +K Sbjct: 338 EGLFRRALEENVAFVPGGPFFANGGGEN-TLRLSYATLDREGIAEGVRRLGRALK 391 >6HNV-A nrPDB Length = 524 Score = 154 bits (389), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 111/387 (28%), Positives = 187/387 (48%), Gaps = 55/387 (14%) Query: 68 MKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEM 127 + R LQY+ G LL + + I+ H P + ++ +T+G+ GL K ++ Sbjct: 124 LARGLQYAAVEGHAPLLQFARDFIIRTHKP-------NYDDWNVFITTGASDGLNKAADV 176 Query: 128 IINPGDNVLLDEPAYSGTLQSLHPLGCNI----INVASDESGIVPDSLRDILSRWKPEDA 183 ++ GD +L++E +S L+ G IN +D GI D+L W+ Sbjct: 177 FLDDGDVILVEEFTFSPFLRFSDNAGAKAVPVKINFDNDSDGIDLTQFVDLLENWEKHYP 236 Query: 184 KNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFR- 242 P+ PK LYT+ G NPTG + + E +K+IY+LA KYDF IIEDDPY +L K+ Sbjct: 237 NLPK---PKALYTIATGQNPTGFTQSLEFRKKIYDLAVKYDFAIIEDDPYGYLTLPKYEK 293 Query: 243 ---------------------------VPTFLSMDVDGRVIRADSFSKIISSGLRIGFLT 275 P++L +D GRV+R ++FSK+ + GLR+GF+ Sbjct: 294 PNIGGSGSGNNELKNDLEIDDYLKNHLTPSYLELDTTGRVLRVETFSKLFAPGLRLGFIV 353 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE--WGEEGFMAHVDRVIDFYSNQKDAI 333 G K +I+ V + V S Q +++ ++ E G +G++ + ++ YS +KD + Sbjct: 354 GHKEVIDAVKNYSDVVNRGASGLTQTIVNNVIQENFKGVDGWLEWILKMRLNYSYRKDLL 413 Query: 334 LAA---ADKWLTGLAEWHVPAAGMFLWIKVKGINDVK-----ELIEEKAVKMGVLMLPGN 385 L + + + G + P AGMF+ K+ DV +L+ K + G+L++PG Sbjct: 414 LYSIFESQAYKKGYVDVIDPKAGMFVTFKINLPKDVDVLQKMKLLLWKLISYGILVVPGY 473 Query: 386 AFYVD---SSAPSPYLRASFSSASPEQ 409 VD S S + R ++ A+ ++ Sbjct: 474 NMTVDLEFSKDRSNFFRLCYALANNDE 500 >1VP4-A nrPDB Length = 425 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 108/395 (27%), Positives = 189/395 (47%), Gaps = 22/395 (5%) Query: 31 KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQL 90 K IS GG+P+P FP K E K I E+ LQYS + G P L + +L Sbjct: 43 KDAISFGGGVPDPETFPRKE---LAEIAKEII--EKEYHYTLQYSTTEGDPVLKQQILKL 97 Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH 150 +++ + + +L T GSQQ L + ++ ++ +LD+PAY G + + Sbjct: 98 LERMYGITGLD------EDNLIFTVGSQQALDLIGKLFLDDESYCVLDDPAYLGAINAFR 151 Query: 151 PLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS 210 N + V ++ G+ + L LS + KN + KF+Y V N +NP G + + Sbjct: 152 QYLANFVVVPLEDDGMDLNVLERKLSEFD----KNGKIKQVKFIYVVSNFHNPAGVTTSL 207 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLR 270 E++K + E+A KYD I+EDDPY L++ V + RV+ ++FSK+++ GLR Sbjct: 208 EKRKALVEIAEKYDLFIVEDDPYGALRYEGETVDPIFKIGGPERVVLLNTFSKVLAPGLR 267 Query: 271 IGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 IG + G K I +++ Q + L + ++ L + + + I+ Y ++ Sbjct: 268 IGMVAGSKEFIRKIVQAKQSADLCSPAITHRLAARYLERY---DLLEQLKPTIELYRRKR 324 Query: 331 DAILAAADKWLTGL--AEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFY 388 +L A +++ + + +W G+F+W+ + D E+ E A + V +PG F Sbjct: 325 TVMLNALEEYFSDIPGVKWVKSEGGLFIWLTLPEGFDTWEMF-EYAKRKKVFYVPGRVFK 383 Query: 389 VDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 V PSP +R SF E++ + L +++ E Sbjct: 384 V-YDEPSPSMRLSFCLPPDEKIVEGIKRLREVVLE 417 >1GC4-A nrPDB Length = 385 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 99/370 (26%), Positives = 168/370 (45%), Gaps = 50/370 (13%) Query: 65 EEMMKRAL-----QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQ 119 +E +RAL +Y+P AGIPEL L + K + P + VT G Q Sbjct: 50 KEAARRALAQGKTKYAPPAGIPELREALAE---KFRRENGLSVTPEE----TIVTVGGSQ 102 Query: 120 GLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS-DESGIVPDSLRDILSRW 178 L +F+ I++PGD V++ P + + + G ++ V + E G VPD Sbjct: 103 ALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPEEGFVPD--------- 153 Query: 179 KPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL- 236 PE + + TP+ V N NNPTG E + + LA ++DF ++ D+ Y L Sbjct: 154 -PERVR--RAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLL 210 Query: 237 ----QFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVST 292 F+ RV ++ V+G A +F+ +G RIG+ GPK +I+ + + ST Sbjct: 211 YEGEHFSPGRVAPEHTLTVNG---AAKAFAM---TGWRIGYACGPKEVIKAMASVSRQST 264 Query: 293 LHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV-PA 351 P T Q + L +E A V+ + Y ++D +L + LT L V P+ Sbjct: 265 TSPDTIAQWATLEALT--NQEASRAFVEMAREAYRRRRDLLL----EGLTALGLKAVRPS 318 Query: 352 AGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMD 411 ++ + I + E+ ++ GV ++PG F A ++R S+++ S E + Sbjct: 319 GAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDF-----AAFGHVRLSYAT-SEENLR 372 Query: 412 VAFQVLAQLI 421 A + A+++ Sbjct: 373 KALERFARVL 382 >1V2E-A nrPDB Length = 381 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 96/361 (26%), Positives = 156/361 (43%), Gaps = 42/361 (11%) Query: 66 EMMKRAL----QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL 121 E ++RAL QY+P AG+P L L + P + VTSG+ + L Sbjct: 45 EAVRRALGRQDQYAPPAGLPALREALAE---------EFAVEPE----SVVVTSGATEAL 91 Query: 122 CKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 + + ++ PGD V++ EP + L G V D + P+ R LS E Sbjct: 92 YVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLD---LTPEGFRLDLSAL--E 146 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 A P+ T L P NPTG + I LAR +D +I D+ Y L + + Sbjct: 147 KALTPR--TRALLLNTP--MNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGE- 201 Query: 242 RVPTFLSMDVDGRVIRADSFSKII-SSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 P L R S K + ++G R+G++ GPK + R+ Q ++ T Q Sbjct: 202 -RPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQ 260 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 +++ L EGF + + + Y ++D L A GL +VP FL ++ Sbjct: 261 AGVAEALKLARREGFY---EALREGYRRRRD--LLAGGLRAMGL-RVYVPEGTYFLMAEL 314 Query: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 G D L+EE V ++P +AFY++ P R +F + E++ +A + L ++ Sbjct: 315 PGW-DAFRLVEEARVA----LIPASAFYLEDP-PKDLFRFAFCK-TEEELHLALERLGRV 367 Query: 421 I 421 + Sbjct: 368 V 368 >1GDE-A nrPDB Length = 389 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 100/415 (24%), Positives = 182/415 (43%), Gaps = 46/415 (11%) Query: 15 NPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQY 74 + S IR + DI + G K +ISL G P+ F T E K E + K Y Sbjct: 11 SASEIRKLFDIAA-GMKDVISLGIGEPD-----FDTPQHIKEYAK-----EALDKGLTHY 59 Query: 75 SPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDN 134 P+ G+ EL + + KL I P + ++ V G+ Q + G+ Sbjct: 60 GPNIGLLELREAIAE---KLKKQNGIEADP---KTEIMVLLGANQAFLMGLSAFLKDGEE 113 Query: 135 VLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLR---DILSRWKPEDAKNPQKNTP 191 VL+ PA+ ++ G + V + E D R D L ++ + + N+P Sbjct: 114 VLIPTPAFVSYAPAVILAGGKPVEVPTYEE----DEFRLNVDELKKYVTDKTRALIINSP 169 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMD- 250 NPTG LT + +EI + ++D ++I D+ Y ++ R + S+D Sbjct: 170 ---------CNPTGAVLTKKDLEEIADFVVEHDLIVISDEVYEHFIYDDARHYSIASLDG 220 Query: 251 VDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE 309 + R I + FSK + +G R+GF+ P +IER++ + P TF Q ++ L + Sbjct: 221 MFERTITVNGFSKTFAMTGWRLGFVAAPSWIIERMVKFQMYNATCPVTFIQYAAAKALKD 280 Query: 310 WGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKEL 369 E + A V+ + Y ++ + ++ GL P +++ +++ + Sbjct: 281 --ERSWKA-VEEMRKEYDRRRKLVWKRLNE--MGLPTVK-PKGAFYIFPRIRDTGLTSKK 334 Query: 370 IEEKAVKMG-VLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 E +K V ++PG+AF A Y+R S+++A E+++ A + +++KE Sbjct: 335 FSELMLKEARVAVVPGSAF---GKAGEGYVRISYATAY-EKLEEAMDRMERVLKE 385 >2O1B-A nrPDB Length = 404 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 93/383 (24%), Positives = 160/383 (41%), Gaps = 63/383 (16%) Query: 20 RTMTDILSRGPKSMISLAGGLPN-PN----MFPFKTAVITVENGKTIQF-GEEMMKRALQ 73 +TM + GP +I++A G+P+ P + F+ A+ EN K F G+E K+A+ Sbjct: 36 KTMGRKIEHGPLPLINMAVGIPDGPTPQGIIDHFQKALTIPENQKYGAFHGKEAFKQAI- 94 Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 + + +Q + L + ++C+ G++ GL V +INPGD Sbjct: 95 ---------VDFYQRQYNVTLDK-----------EDEVCILYGTKNGLVAVPTCVINPGD 134 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 VLL +P Y+ L + + + + +PD W D++ K + Sbjct: 135 YVLLPDPGYTDYLAGVLLADGKPVPLNLEPPHYLPD--------WSKVDSQIIDKTKLIY 186 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDG 253 L T P NNPTG++ T E E + D I+ D Y F+ S + Sbjct: 187 L-TYP--NNPTGSTATKEVFDEAIAKFKGTDTKIVHDFAYGAFGFDAKNPSILASENGKD 243 Query: 254 RVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGE 312 I S SK + SG R+GF G K +I+ + Q T N M L + Sbjct: 244 VAIEIYSLSKGYNMSGFRVGFAVGNKDMIQ-ALKKYQTHT------NAGMFGAL-----Q 291 Query: 313 EGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVP----AAGMFLWIKVKGINDVKE 368 + + ++ DF Q + D++ LA+ +P G+++W++ D ++ Sbjct: 292 DAAIYALNHYDDFLEEQSNVFKTRRDRFEAMLAKADLPFVHAKGGIYVWLETPPGYDSEQ 351 Query: 369 ----LIEEKAVKMGVLMLPGNAF 387 L++EK+ +L+ PG F Sbjct: 352 FEQFLVQEKS----ILVAPGKPF 370 >5WMH-A nrPDB Length = 475 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 106/432 (24%), Positives = 190/432 (43%), Gaps = 66/432 (15%) Query: 15 NPSPIRTMTDILSRGPKS---MISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRA 71 PS +TD+ + +S +I LA G P+ F T + E G I E R Sbjct: 80 KPSKTMVITDLAATLVQSGVPVIRLAAGEPD-----FDTPKVVAEAG--INAIREGFTR- 131 Query: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 Y+ +AGI EL + + KL + Y P Q + V++G++Q L + + +P Sbjct: 132 --YTLNAGITELREAICR---KLKEENGLSYAPDQ----ILVSNGAKQSLLQAVLAVCSP 182 Query: 132 GDNVLLDEPAY-SGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 GD V++ P + S T Q+ +A ++P + + P+D ++ Sbjct: 183 GDEVIIPAPYWVSYTEQA---------RLADATPVVIPTKISNNF-LLDPKDLESKLTEK 232 Query: 191 PKFLYTVPNGNNPTGNSLTSERKKEIYELARKY-DFLIIEDDPYYFLQFNKFRVPTFLSM 249 + L + + +NPTG+ +EI + K+ L++ D+ Y + + +F S+ Sbjct: 233 SRLL-ILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPATHTSFASL 291 Query: 250 -DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVI-LHIQVSTLHPSTFNQLMISQL 306 D+ R + + FSK + +G R+G+L GPK ++ L QVS+ S + ++ L Sbjct: 292 PDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQKAGVAAL 351 Query: 307 -LHEWGEEGFMAHVDRVIDFYSNQKDAILAA-ADKWLTGLAEWHVPAAGMFLWIKVKG-- 362 L + G E V ++ Y ++D ++ + D ++E P +L+I Sbjct: 352 GLGKAGGE----TVAEMVKAYRERRDFLVKSLGDIKGVKISE---PQGAFYLFIDFSAYY 404 Query: 363 ---------INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVA 413 IND L K V M+PG+AF DS +R S++++ +DV Sbjct: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSC-----IRISYATS----LDV- 454 Query: 414 FQVLAQLIKESL 425 Q + I+++L Sbjct: 455 LQAAVEKIRKAL 466 >1J32-A nrPDB Length = 388 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 132/302 (43%), Gaps = 43/302 (14%) Query: 12 AARNPSPIRTMTDILSRGPKSM-------ISLAGGLPNPNM--FPFKTAVITVENGKTIQ 62 AAR S +MT I+ K+M S + G P+ N + A +E GKT Sbjct: 4 AARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGKT-- 61 Query: 63 FGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLC 122 +Y P+AG P L + Q KL + Y G ++ VT+G +Q + Sbjct: 62 ----------RYGPAAGEPRLREAIAQ---KLQRDNGLCY----GADNILVTNGGKQSIF 104 Query: 123 KVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED 182 + +I PGD V++ P + +P ++ +A I+P ++ +++K Sbjct: 105 NLMLAMIEPGDEVIIPAPFWVS-----YP---EMVKLAEGTPVILPTTVE---TQFKVSP 153 Query: 183 AKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 + Q TPK V N +NPTG T + + I ++A + ++ D+ Y + ++ Sbjct: 154 EQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVLSDEIYEKILYDDA 213 Query: 242 RVPTF--LSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTF 298 + + S + R + F+K + +G R+GFL GP PL++ ST + TF Sbjct: 214 QHLSIGAASPEAYERSVVCSGFAKTYAMTGWRVGFLAGPVPLVKAATKIQGHSTSNVCTF 273 Query: 299 NQ 300 Q Sbjct: 274 AQ 275 >3OP7-A nrPDB Length = 375 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 73/315 (23%), Positives = 140/315 (44%), Gaps = 38/315 (12%) Query: 114 TSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNI-INVASDESGIVPD--S 170 T+G+ V +I PGD+V+ P Y LG + + +E+G +PD Sbjct: 87 TNGATGANLLVLYSLIEPGDHVISLYPTYQQLYDIPKSLGAEVDLWQIEEENGWLPDLEK 146 Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 LR ++ + T K + + N NNPTG + +E+ E+A + I+ D Sbjct: 147 LRQLI------------RPTTKMI-CINNANNPTGAVMDRTYLEELVEIASEVGAYILSD 193 Query: 231 DPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQ 289 + Y F++ VP+ + +V + I +S SK S G+RIG++ + + + + Sbjct: 194 EVYR--SFSELDVPSII--EVYDKGIAVNSLSKTYSLPGIRIGWVAANHQVTDILRDYRD 249 Query: 290 VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTG--LAEW 347 + + F+ L ++QL +AH +++ + + LA D+W+ L + Sbjct: 250 YTMICAGVFDDL-VAQLA--------LAHYQEILERNRHILEENLAILDQWIEEEPLVSY 300 Query: 348 HVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASP 407 PA ++K+ +++ + + GVL++PGN F D Y+R F + Sbjct: 301 IRPAVVSTSFVKIAVDMPMEDFCLQLLQEHGVLLVPGNRFERDG-----YVRLGF-ACEQ 354 Query: 408 EQMDVAFQVLAQLIK 422 E + + L+Q ++ Sbjct: 355 ETLIKGLEKLSQFLR 369 >1O4S-A nrPDB Length = 389 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 80/349 (22%), Positives = 150/349 (42%), Gaps = 50/349 (14%) Query: 75 SPSAGIPELLSWLKQLQIKLHNPPTIH-------------YPPSQGQMDLCVTSGSQQGL 121 +P + E + +L++ ++K +P I+ Y + VT+G++Q L Sbjct: 55 TPEPVVEEAVRFLQKGEVKYTDPRGIYELREGIAKRIGERYKKDISPDQVVVTNGAKQAL 114 Query: 122 CKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 F +++PGD V++ P + + + G + V + S SL ++ + Sbjct: 115 FNAFMALLDPGDEVIVFSPVWVSYIPQIILAGGTVNVVETFMSKNFQPSLEEVEGLLVGK 174 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQF-NK 240 K N+P NNPTG E + + LA+K +F II D+ Y L + ++ Sbjct: 175 -TKAVLINSP---------NNPTGVVYRREFLEGLVRLAKKRNFYIISDEVYDSLVYTDE 224 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFN 299 F +S D R++ + FSK S +G R+G+L E+V + H ++ Sbjct: 225 FTSILDVSEGFD-RIVYINGFSKSHSMTGWRVGYLISS----EKVATAVSKIQSHTTS-- 277 Query: 300 QLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIK 359 I+ + + ++ + +K+ ++ K E P +L+ K Sbjct: 278 --CINTVAQYAALKALEVDNSYMVQTFKERKNFVVERLKKMGVKFVE---PEGAFYLFFK 332 Query: 360 VKGINDVK---ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA 405 V+G +DVK L+EEK V ++PG+AF ++R SF+++ Sbjct: 333 VRG-DDVKFCERLLEEKKVA----LVPGSAFL-----KPGFVRLSFATS 371 >2X5D-A nrPDB Length = 412 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 70/297 (23%), Positives = 125/297 (42%), Gaps = 42/297 (14%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 YS S GIP L + ++ + P + + VT GS++GL + ++ GD Sbjct: 71 YSTSRGIPRLRRAISHWYRDRYD---VQIDP---ESEAIVTIGSKEGLAHLMLATLDHGD 124 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD-SLRDILSRWKPEDAKNPQKNTPK 192 +L+ P+Y +H G I +VP + L R E P+ Sbjct: 125 TILVPNPSYP-----IHIYGAVIAGAQVRSVPLVPGIDFFNELERAIRESIPKPRMMILG 179 Query: 193 FLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD 252 F +NPT + + + + LA++YD +++ D Y + ++ ++ P+ M V Sbjct: 180 F------PSNPTAQCVELDFFERVVALAKQYDVMVVHDLAYADIVYDGWKAPSI--MQVP 231 Query: 253 GRVIRADSFSKIISS----GLRIGFLTGPKPLIERVILHIQVSTLHP-STFNQLMISQLL 307 G A F + S G RIGF+ G L+ + ++ + H TF L ++ + Sbjct: 232 GAKDIAVEFFTLSKSYNMAGWRIGFMVGNPELVSAL---ARIKSYHDYGTFTPLQVAAIA 288 Query: 308 HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE--WHV--PAAGMFLWIKV 360 G++ + + R Y ++D + + GL E W V P A M++W K+ Sbjct: 289 ALEGDQQCVRDIARQ---YQQRRDVL-------VKGLREAGWMVENPKASMYVWAKI 335 >4N0B-A nrPDB Length = 479 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/252 (23%), Positives = 102/252 (40%), Gaps = 41/252 (16%) Query: 122 CKVFEMIINPGDNVLL---------------DEPAYSGTLQSLHPLGCNIINVASDESGI 166 C+ +MII G VL+ +EP Y Q L G + + DE G+ Sbjct: 170 CRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQVKTIMLDEKGM 229 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA----RK 222 S+ +I + P L T P+ P+G + R+ ++ A R+ Sbjct: 230 ---SIAEIT------------RQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRR 274 Query: 223 YDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIE 282 Y IIEDD ++ +P S+D VI +FSK + GLRI ++ P L+ Sbjct: 275 Y---IIEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELL- 330 Query: 283 RVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT 342 R S+ QL + + + E GE + H+ ++ Y +++ ++ A + + Sbjct: 331 RAYKQRGYDLQTCSSLTQLTLQEFI-ESGE--YQKHIKKMKQHYKEKRERLITALEAEFS 387 Query: 343 GLAEWHVPAAGM 354 G AG+ Sbjct: 388 GEVTVKGANAGL 399 >5X03-B nrPDB Length = 365 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 41/241 (17%) Query: 122 CKVFEMIINPGDNVLL---------------DEPAYSGTLQSLHPLGCNIINVASDESGI 166 C+ +MII G VL+ +EP Y Q L G + + DE G+ Sbjct: 63 CRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQVKTIMLDEKGM 122 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA----RK 222 S+ +I + P L T P+ P+G + R+ ++ A R+ Sbjct: 123 ---SIAEIT------------RQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRR 167 Query: 223 YDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIE 282 Y IIEDD ++ +P S+D VI +FSK + GLRI ++ P L+ Sbjct: 168 Y---IIEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELL- 223 Query: 283 RVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT 342 R S+ QL + + + E GE + H+ ++ Y +++ ++ A + + Sbjct: 224 RAYKQRGYDLQTCSSLTQLTLQEFI-ESGE--YQKHIKKMKQHYKEKRERLITALEAEFS 280 Query: 343 G 343 G Sbjct: 281 G 281 >4MY5-A nrPDB Length = 393 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 79/366 (21%), Positives = 153/366 (41%), Gaps = 33/366 (9%) Query: 65 EEMMKRALQYSPS--AGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLC 122 +E KRA+ S G+ LL+ + + + Y P ++ VT G+ + L Sbjct: 51 KEAAKRAIDADESHYTGMAGLLALRQAASAFVKEKYHLTYNPDN---EILVTIGATEALS 107 Query: 123 KVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNI--INVASDESGIVPDSLRDILSRWKP 180 I+ PGD VLL PAY G ++ +G + I+ S++ + P+ L + + + + Sbjct: 108 ASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEIDTRSNDFVLTPEMLEEAILK-EG 166 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 E K N P NPTG + + ++ K + E+ +KY +I D+ Y L + Sbjct: 167 EALKAVILNYP---------TNPTGVTYSRQQIKNLAEVLKKYPIFVISDEVYAELTYTG 217 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 + D ++ + +G R+G + P L ++I Q +T Q Sbjct: 218 ESHVSIAEYLPDQTILISGLSKSHAMTGWRLGLIFAPAVLTAQLIKSHQYLVTAATTSVQ 277 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 + L ++ + Y ++D I+ + + + P +++ K+ Sbjct: 278 FAAIEALTNGKDDALPMKEE-----YIKRRDYIIEKMEAMKFKIIK---PDGAFYIFAKI 329 Query: 361 ---KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVL 417 +G + K +++ A + V +PG AF YLR S+ +AS E + A + L Sbjct: 330 PVAQGQDSFK-FLQDFAKEKAVAFIPGVAF---GKYGEGYLRISY-AASMETIKEAMKRL 384 Query: 418 AQLIKE 423 + +++ Sbjct: 385 KEFMEQ 390 >3IF2-A nrPDB Length = 444 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 97/242 (40%), Gaps = 39/242 (16%) Query: 202 NPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV----DGRVIR 257 NPTGN LT E + E+A++YD +I D+ Y P + D D I Sbjct: 217 NPTGNVLTDEEMAHLAEIAKRYDIPLIIDNAY------GMPFPNIIYSDAHLNWDNNTIL 270 Query: 258 ADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMA 317 S SKI G+R G + +IE V V L P+ F + + L+ Sbjct: 271 CFSLSKIGLPGMRTGIIVADAKVIEAVSAMNAVVNLAPTRFGAAIATPLVAN-------- 322 Query: 318 HVDRVIDFYSN------QKDAILAAADKWLT-GLAEW----HVPAAGMFLWIKVKGINDV 366 DR+ N QK A LA K L L ++ H P +FLW+ K + Sbjct: 323 --DRIKQLSDNEIKPFYQKQATLAV--KLLKQALGDYPLMIHKPEGAIFLWLWFKDLPIS 378 Query: 367 KELIEEKAVKMGVLMLPGNAFY-----VDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 + E+ G L++P F+ D +R S ++ +D +V+ +++ Sbjct: 379 TLDLYERLKAKGTLIVPSEYFFPGVDVSDYQHAHECIRMSIAADEQTLID-GIKVIGEVV 437 Query: 422 KE 423 +E Sbjct: 438 RE 439 >6F77-B nrPDB Length = 400 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 113/259 (43%), Gaps = 37/259 (14%) Query: 31 KSMISLAGGLPN---PNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWL 87 + +I L G P+ P+ K A+ ++ G+T +Y+P +GIPEL + Sbjct: 31 RDVIGLGAGEPDFDTPDNIK-KAAIDAIDRGET------------KYTPVSGIPELREAI 77 Query: 88 KQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQ 147 + K + Y +Q V +G +Q L F +NPGD V++ P + + Sbjct: 78 AK---KFKRENNLDYTAAQ----TIVGTGGKQILFNAFMATLNPGDEVVIPAPYWVSYPE 130 Query: 148 SLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS 207 + G + V + + D+ P+ T F++ P +NP+G + Sbjct: 131 MVALCGGTPVFVPTRQENNFKLKAEDLDRAITPK--------TKWFVFNSP--SNPSGAA 180 Query: 208 LTSERKKEIYELARKYDFL-IIEDDPYYFLQFNKFRVPTFLSMD--VDGRVIRADSFSKI 264 + E K + ++ K+ + ++ DD Y L + FR T + ++ + R + + SK Sbjct: 181 YSHEELKALTDVLMKHPHVWVLTDDMYEHLTYGDFRFATPVEVEPGLYERTLTMNGVSKA 240 Query: 265 IS-SGLRIGFLTGPKPLIE 282 + +G RIG+ GP LI+ Sbjct: 241 YAMTGWRIGYAAGPLHLIK 259 >3EZ1-A nrPDB Length = 423 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 121/298 (40%), Gaps = 31/298 (10%) Query: 140 PAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN 199 P Y L LG ++ V G PD D + R D + K + VP Sbjct: 132 PGYDRHFLLLQTLGFELLTVDMQSDG--PDV--DAVERLAGTDP------SVKGILFVPT 181 Query: 200 GNNPTGNSLTSERKKEIYEL-ARKYDFLIIEDDPY---YFLQFNKFRVPTFLSMDVDG-- 253 +NP G +++ E+ + + L A DF I DD Y + ++ ++ F+ + D Sbjct: 182 YSNPGGETISLEKARRLAGLQAAAPDFTIFADDAYRVHHLVEEDRAEPVNFVVLARDAGY 241 Query: 254 --RVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW- 310 R S SKI +G +GF+ + I + ++ ++ P+ Q + L E+ Sbjct: 242 PDRAFVFASTSKITFAGAGLGFVASSEDNIRWLSKYLGAQSIGPNKVEQARHVKFLTEYP 301 Query: 311 -GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKEL 369 G EG M +I D +L A A W +P G F+ + D E Sbjct: 302 GGLEGLMRDHAAIIAPKFRAVDEVLRAELGEGGEYATWTLPKGGYFISL------DTAEP 355 Query: 370 IEEKAVKM----GVLMLPGNAFYVDSSAP-SPYLRASFSSASPEQMDVAFQVLAQLIK 422 + ++ VK+ GV + P A Y P + LR + + E++ A QV+A I+ Sbjct: 356 VADRVVKLAEAAGVSLTPAGATYPAGQDPHNRNLRLAPTRPPVEEVRTAMQVVAACIR 413 >3G7Q-A nrPDB Length = 417 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/241 (22%), Positives = 109/241 (45%), Gaps = 20/241 (8%) Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDD----PYYFLQFNKFRVPTFLSM 249 + V NPTGN +T E ++ LA +++ ++ D+ P+ + F++ R P + Sbjct: 183 MICVSRPTNPTGNVITDEELMKLDRLANQHNIPLVIDNAYGVPFPGIIFSEAR-PLW--- 238 Query: 250 DVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE 309 + +I S SK+ G R G + I + + +L P M+ +++ Sbjct: 239 --NPNIILCMSLSKLGLPGSRCGIIIANDKTITAIANMNGIISLAPGGMGPAMMCEMIKR 296 Query: 310 WGEEGFMAHVDRVID-FYSNQKDAILAAADKWLTG-LAEWHVPAAGMFLWIKVKGINDVK 367 + + VI FY + +A ++L+ H P +FLW+ K + Sbjct: 297 ---NDLLRLSETVIKPFYYQRVQQTIAIIRRYLSEERCLIHKPEGAIFLWLWFKDLPITT 353 Query: 368 ELIEEKAVKMGVLMLPGNAFYVDSSAPSPY----LRASFSSASPEQMDVAFQVLAQLIKE 423 EL+ ++ GVLM+PG+ F+ P P+ +R ++ P++++ ++LA+ I+ Sbjct: 354 ELLYQRLKARGVLMVPGHYFFPGLDKPWPHTHQCMRMNYVP-EPDKIEAGVKILAEEIER 412 Query: 424 S 424 + Sbjct: 413 A 413 >6F35-A nrPDB Length = 410 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 77/356 (21%), Positives = 152/356 (42%), Gaps = 54/356 (15%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMD-LCVTSGSQQGLCKVFEMIINP 131 +Y+ G PEL K ++ K + Y ++D + V +G++Q L ++P Sbjct: 73 KYTALDGTPELK---KAIREKFQRENGLAY-----ELDEITVATGAKQILFNAMMASLDP 124 Query: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 GD V++ P ++ +H + +A D S S ++ K TP Sbjct: 125 GDEVIIPTPYWTSYSDIVHICEGKPVLIACDAS-----------SGFRLTAEKLEAAITP 173 Query: 192 KFLYTVPNG-NNPTGNSLTSERKKEIYE-LARKYDFLIIEDDPYYFLQFNKFR--VPTFL 247 + + + N +NP+G + ++ + + E L R ++ DD Y + ++ FR P L Sbjct: 174 RTRWVLLNSPSNPSGAAYSAADYRPLLEVLLRHPHVWLLVDDMYEHIVYDGFRFVTPAQL 233 Query: 248 SMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQL 306 + R + + SK + +G RIG+ GP+ LI+ + + +T PS+ +Q Sbjct: 234 EPGLKNRTLTVNGVSKAYAMTGWRIGYAGGPRELIKAMAVVQSQATSCPSSISQAASVVA 293 Query: 307 LHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI--- 363 L+ G + F+ + + ++D ++ + + GL + VP + + G+ Sbjct: 294 LN--GPQDFL---KERTESFQRRRDLVVNGLNA-IDGL-DCRVPEGAFYTFSGCAGVLGK 346 Query: 364 -----------NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPE 408 D + E A V ++PG+AF + SP+ R S++++ E Sbjct: 347 VTPSGKRIKTDTDFCAYLLEDA---HVAVVPGSAFGL-----SPFFRISYATSEAE 394 >1U08-A nrPDB Length = 386 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 71/348 (20%), Positives = 141/348 (40%), Gaps = 34/348 (9%) Query: 62 QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL 121 + + + A QY+P G+ L + Q +L+ Y P D+ VT+G+ + L Sbjct: 51 RLAHHVAQGANQYAPMTGVQALREAIAQKTERLYG-----YQPD-ADSDITVTAGATEAL 104 Query: 122 CKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 ++ GD V+ +P+Y ++ G + +A + P R W+ E Sbjct: 105 YAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMA-----LQPPHFR---VDWQ-E 155 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 A + T + P +NP+ +++ ++ +I D+ Y + F++ Sbjct: 156 FAALLSERTRLVILNTP--HNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQ 213 Query: 242 RVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFN 299 + L+ + R + SF K +G ++G+ P P+ + Q T +T Sbjct: 214 GHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEIRKVHQYLTFSVNTPA 273 Query: 300 QLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFL--- 356 QL ++ +L E H + DFY ++D ++ A ++ + +P G + Sbjct: 274 QLALADMLRAEPE-----HYLALPDFYRQKRDILVNALNESRLEI----LPCEGTYFLLV 324 Query: 357 -WIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFS 403 + V ++DV E + + GV +P + F D P +R F+ Sbjct: 325 DYSAVSTLDDV-EFCQWLTQEHGVAAIPLSVFCADPF-PHKLIRLCFA 370 >5YHV-A nrPDB Length = 394 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 88/232 (37%), Gaps = 22/232 (9%) Query: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 L YS + GIPEL + + H I P + +T+GS G F + Sbjct: 68 LGYSVALGIPELRDAIAADYQRRHG---ITVEPDA----VVITTGSSGGFLLAFLACFDA 120 Query: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 GD V + P Y L LGC ++ + +R++P + + P Sbjct: 121 GDRVAMASPGYPCYRNILSALGCEVVEIPCGPQ-----------TRFQPTAQMLAEIDPP 169 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVP-TFLSMD 250 V + NPTG + E I D +I D+ Y+ L + P T + Sbjct: 170 LRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQG--APQTSCAWQ 227 Query: 251 VDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 + +SFSK + +G R+G+L P L V T+ P +Q+ Sbjct: 228 TSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQI 279 >2GB3-A nrPDB Length = 409 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 123/295 (41%), Gaps = 50/295 (16%) Query: 74 YSPSAGIPEL----LSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII 129 YS SAGI EL S+ K+ Q + P ++ VT+G + + F +I Sbjct: 75 YSHSAGIWELREAFASYYKRRQ-------RVDVKPE----NVLVTNGGSEAILFSFAVIA 123 Query: 130 NPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS--DESGIVPDSLRDILSRWKPEDAKNPQ 187 NPGD +L+ EP Y+ G +I V +E +P +L ++ E K Sbjct: 124 NPGDEILVLEPFYANYNAFAKIAGVKLIPVTRRMEEGFAIPQNLESFIN----ERTKG-- 177 Query: 188 KNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFL 247 + N NPTG + + + E+A ++ +I D+ Y + F + + L Sbjct: 178 -------IVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYSEIVF-RGEFASAL 229 Query: 248 SMDVDGRVIRADSFSKIISS-GLRIGFL-TGPKPLIERVILHIQVSTLHPSTFNQLMISQ 305 S++ D +V+ DS SK S+ G R+G L T + LI + Q P Sbjct: 230 SIESD-KVVVIDSVSKKFSACGARVGCLITRNEELISHAMKLAQGRLAPP---------- 278 Query: 306 LLHEWGEEGFMAHVDRVIDF----YSNQKDAILAAADKWLTGLAEWHVPAAGMFL 356 LL + G G + D DF Y + + +L ++ GL + P+ ++ Sbjct: 279 LLEQIGSVGLLNLDDSFFDFVRETYRERVETVLKKLEEH--GLKRFTKPSGAFYI 331 >3B46-A nrPDB Length = 447 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 23/225 (10%) Query: 62 QFGEEMMKRAL------QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTS 115 QF + ++AL QYSP+ G P L++ L IKL++P Y ++ VT+ Sbjct: 73 QFAIKEAQKALDIPMVNQYSPTRGRPSLINSL----IKLYSPI---YNTELKAENVTVTT 125 Query: 116 GSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 G+ +G+ ++N GD V++ EP + + ++ G ++ V + P L Sbjct: 126 GANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINP----PKELDQRN 181 Query: 176 SR---WKPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLIIEDD 231 +R W + + + T K + N +NP G T E + + K++ +II D+ Sbjct: 182 TRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 241 Query: 232 PYYFLQF-NKFRVPTFLSMDVDGRVIRADSFSK-IISSGLRIGFL 274 Y L F + F LS ++ + S K ++G RIG++ Sbjct: 242 VYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 286 >3H14-A nrPDB Length = 391 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 78/357 (21%), Positives = 140/357 (39%), Gaps = 41/357 (11%) Query: 57 NGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 G + + AL Y+ + G+P L + +L + + + P + + +T G Sbjct: 47 RGAVEALAKSLETDALGYTVALGLPALRQRIARLYGEWYG---VDLDPGR----VVITPG 99 Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 S G F + + GD V + P Y Q L LG +++ + P+ + Sbjct: 100 SSGGFLLAFTALFDSGDRVGIGAPGYPSYRQILRALGLVPVDLPT-----APE------N 148 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 R +P A + + P NPTG L + E A+ I D+ Y+ + Sbjct: 149 RLQPVPADFAGLDLAGLMVASP--ANPTGTMLDHAAMGALIEAAQAQGASFISDEIYHGI 206 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKP---LIERVILHIQVST 292 ++ V T L + + VI +SFSK S +G R+G++ P+ ++ER+ ++ + Sbjct: 207 EYEAKAV-TALELTDECYVI--NSFSKYFSMTGWRVGWMVVPEDQVRVVERIAQNMFICA 263 Query: 293 LHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAA 352 H S L E + +D Y + +L K G P Sbjct: 264 PHASQVAALAALDCDAE---------LQANLDVYKANRKLMLERLPK--AGFTRIAPPDG 312 Query: 353 GMFLWIKVKGI-NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPE 408 +++ V + +D + E K GV + PG F D + LR S++ A+ + Sbjct: 313 AFYVYADVSDLTDDSRAFAAEILEKAGVAVTPGLDF--DPERGAGTLRFSYARATAD 367 >4CVQ-A nrPDB Length = 431 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/173 (26%), Positives = 79/173 (45%), Gaps = 15/173 (8%) Query: 110 DLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 D+ + +G + + + + ++N GD +L+ P Y PL ++++S G Sbjct: 123 DIYIGNGVSELIVQAMQALLNSGDEMLVPAPDY--------PLWTAAVSLSS---GKAVH 171 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFL-YTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 L D S W P+ K TP+ + N NNPTG + E EI E+AR+++ +I Sbjct: 172 YLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIF 231 Query: 229 EDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGF--LTGPK 278 D+ Y + ++ + + D I + SK +G R G+ L GPK Sbjct: 232 ADEIYDKILYDDAEHHSIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVLNGPK 284 >2DOU-A nrPDB Length = 376 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 112/258 (43%), Gaps = 31/258 (12%) Query: 116 GSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVP---DSLR 172 GSQ+GL + + P D +LL E AY P VAS + ++P D L Sbjct: 95 GSQEGLAHLLLALTEPEDLLLLPEVAY--------PSYFGAARVASLRTFLIPLREDGLA 146 Query: 173 DILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDP 232 D+ + PE K L P NNPTG +E LARK+ +I D+P Sbjct: 147 DL--KAVPEGVWREAK---VLLLNYP--NNPTGAVADWGYFEEALGLARKHGLWLIHDNP 199 Query: 233 YYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQV 290 Y Q + P+ L++ RV+ S SK + +G R+GF G + + R+ V Sbjct: 200 YVD-QVYEGEAPSPLALPGAKERVVELFSLSKSYNLAGFRLGFALGSEEALARLERVKGV 258 Query: 291 STLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVP 350 FNQ + +L G E + V + ++ L A+ L G+ P Sbjct: 259 -----IDFNQ--YAGVLR-MGVEALKTPKEVVRGYARVYRERALGMAEA-LKGVLSLLPP 309 Query: 351 AAGMFLWIKV-KGINDVK 367 A M+LW ++ +G++D++ Sbjct: 310 RATMYLWGRLPEGVDDLE 327 >5IWQ-A nrPDB Length = 434 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 67/294 (22%), Positives = 121/294 (41%), Gaps = 29/294 (9%) Query: 140 PAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN 199 P Y G +I+V +E G D++ +++ KNPQ K ++ VP Sbjct: 140 PGYDRHFSITERFGFEMISVPMNEDGPDMDAVEELV--------KNPQV---KGMWVVPV 188 Query: 200 GNNPTGNSLTSERKKEIYELARKY-DFLIIEDDPYYFLQFNKFRVPTFLSMDVDG----- 253 +NPTG ++T + K + + DF ++ D+ Y P + + G Sbjct: 189 FSNPTGFTVTEDVAKRLSAMETAAPDFRVVWDNAYAVHTLTD-EFPEVIDIVGLGEAAGN 247 Query: 254 --RVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWG 311 R S SKI +G + F + H + + P+ NQL ++ + Sbjct: 248 PNRFWAFTSTSKITLAGAGVSFFLTSAENRKWYTGHAGIRGIGPNKVNQLAHARYFGD-- 305 Query: 312 EEGFMAHVDRVIDFYSNQKDAILAAADKWLT--GLAEWHVPAAGMFLWIKV--KGINDVK 367 EG A + + + + + +L D L G+A+W VPA G F+ + V + V Sbjct: 306 AEGVRAVMRKHAASLAPKFNKVLEILDSRLAEYGVAQWTVPAGGYFISLDVVPGTASRVA 365 Query: 368 ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 EL +E + L G+++ + + LR + S E+++VA +A + Sbjct: 366 ELAKEAGI---ALTGAGSSYPLRQDPENKNLRLAPSLPPVEELEVAMDGVATCV 416 >1XI9-A nrPDB Length = 406 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 92/205 (44%), Gaps = 25/205 (12%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y S G+PEL + + + + + + P D+ VT+ + L +F +++PGD Sbjct: 74 YGDSEGLPELRKAIVEREKRKNG---VDITPD----DVRVTAAVTEALQLIFGALLDPGD 126 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP--EDAKNPQKNTP 191 +L+ P+Y + G + + E W+P +D + + Sbjct: 127 EILVPGPSYPPYTGLVKFYGGKPVEYRTIEE-----------EDWQPDIDDIRKKITDRT 175 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRV-PTFLSMD 250 K + V N NNPTG + +EI +A +Y+ +I D+ Y + + + P L+ D Sbjct: 176 KAI-AVINPNNPTGALYDKKTLEEILNIAGEYEIPVISDEIYDLMTYEGEHISPGSLTKD 234 Query: 251 VDGRVIRADSFSKI-ISSGLRIGFL 274 V VI + SK+ ++G R+G++ Sbjct: 235 VP--VIVMNGLSKVYFATGWRLGYM 257 >3JTX-A nrPDB Length = 396 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 101/221 (45%), Gaps = 26/221 (11%) Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD- 252 L V + NNP+G+ L + KE+++L KY F+I D+ Y + F+ + L Sbjct: 171 LVFVCSPNNPSGSVLDLDGWKEVFDLQDKYGFIIASDECYSEIYFDGNKPLGCLQAAAQL 230 Query: 253 GR----VIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLL 307 GR ++ S SK + GLR GF+ G L++ +L+ T H S + + + Sbjct: 231 GRSRQKLLMFTSLSKRSNVPGLRSGFVAGDAELLKNFLLY---RTYHGSAMSIPVQRASI 287 Query: 308 HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDV- 366 W +E HV Y + + ++ L + + +P A ++W+KV +D+ Sbjct: 288 AAWDDE---QHVIDNRRLYQEKFERVIPI----LQQVFDVKLPDASFYIWLKVPDGDDLA 340 Query: 367 --KELIEEKAVKMGVLMLPGNAFYVDSSAPSP---YLRASF 402 + L ++ A++ +LPG D+ +P Y+R + Sbjct: 341 FARNLWQKAAIQ----VLPGRFLARDTEQGNPGEGYVRIAL 377 >2O0R-A nrPDB Length = 411 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 71/294 (24%), Positives = 114/294 (38%), Gaps = 41/294 (13%) Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV--ASDESG 165 + ++ VT G+ + + ++ PG VLL EP Y + G + + V D G Sbjct: 86 ETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRG 145 Query: 166 IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDF 225 D+ D L R + N+P +NPTG L++ I E+A + Sbjct: 146 FALDA--DALRRAVTPRTRALIINSP---------HNPTGAVLSATELAAIAEIAVAANL 194 Query: 226 LIIEDDPYYFLQFNKFRVPTFLSMD-VDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIER 283 ++I D+ Y L F+ R D + R I S +K+ + +G +IG+ GP LI Sbjct: 195 VVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAELIAG 254 Query: 284 VILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVID----FYSNQKDAILAAADK 339 V Q L G F V +D + + ++++ A D+ Sbjct: 255 V----------------RAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDR 298 Query: 340 WLTGLAEW----HVPAAGMFLWIKVK--GINDVKELIEEKAVKMGVLMLPGNAF 387 GL E H FL + G +D E K+GV +P +AF Sbjct: 299 LAAGLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMSAF 352 >3FVS-A nrPDB Length = 422 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/199 (22%), Positives = 91/199 (45%), Gaps = 4/199 (2%) Query: 110 DLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 ++ VT G L F+ +++ GD V++ EP + G + V S + G + + Sbjct: 93 NVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFV-SLKPGPIQN 151 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLII 228 S W+ + + K T + V N NNP G + E + + L +++D + I Sbjct: 152 GELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCI 211 Query: 229 EDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVIL 286 D+ Y ++ ++ + + S+ + R + S K S +G ++G++ GP +++ + Sbjct: 212 TDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRT 271 Query: 287 HIQVSTLHPSTFNQLMISQ 305 Q S H T +Q +++ Sbjct: 272 VHQNSVFHCPTQSQAAVAE 290 >4WP0-A nrPDB Length = 472 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/199 (22%), Positives = 91/199 (45%), Gaps = 4/199 (2%) Query: 110 DLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 ++ VT G L F+ +++ GD V++ EP + G + V S + G + + Sbjct: 93 NVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFV-SLKPGPIQN 151 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLII 228 S W+ + + K T + V N NNP G + E + + L +++D + I Sbjct: 152 GELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCI 211 Query: 229 EDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVIL 286 D+ Y ++ ++ + + S+ + R + S K S +G ++G++ GP +++ + Sbjct: 212 TDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRT 271 Query: 287 HIQVSTLHPSTFNQLMISQ 305 Q S H T +Q +++ Sbjct: 272 VHQNSVFHCPTQSQAAVAE 290 >3NRA-A nrPDB Length = 407 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 65/294 (22%), Positives = 121/294 (41%), Gaps = 29/294 (9%) Query: 104 PSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDE 163 P + L +T G+Q L + GD V + +P Y + + ++ V D Sbjct: 98 PVDARDGLIITPGTQGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEGEMVPVQLDY 157 Query: 164 SGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKY 223 + D R L E+A FL++ P NNP G ++E +I LA +Y Sbjct: 158 --VSADETRAGLDLTGLEEAFKAGARV--FLFSNP--NNPAGVVYSAEEIGQIAALAARY 211 Query: 224 DFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-------SGLRIGFLTG 276 +I D Y L++ ++ + + + A++ I+ SG R+G G Sbjct: 212 GATVIADQLYSRLRYAG---ASYTHLRAEA-AVDAENVVTIMGPSKTESLSGYRLGVAFG 267 Query: 277 PKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEE--GFMAHVDRVIDFYSNQKDAIL 334 + +I R+ + +L + ++Q +L W +E G+M DR+ + +D +L Sbjct: 268 SRAIIARMEKLQAIVSLRAAGYSQ----AVLRGWFDEAPGWME--DRIAR-HQAIRDELL 320 Query: 335 AAADKWLTGLAEWHVPAAGMFLWIKVKGINDV-KELIEEKAVKMGVLMLPGNAF 387 A P AG +L+ ++ + E ++ ++ GV++ PG F Sbjct: 321 HVLRGCEGVFA--RTPQAGSYLFPRLPKLAVAPAEFVKILRLQAGVVVTPGTEF 372 >3DYD-A nrPDB Length = 427 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/275 (23%), Positives = 115/275 (41%), Gaps = 43/275 (15%) Query: 12 AARNPSPIRTMTDILSRGP---KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMM 68 A + +PIR + D + P K+MISL+ G +P +F N T + M Sbjct: 32 AKKTFNPIRAIVDNMKVKPNPNKTMISLSIG--DPTVF---------GNLPTDPEVTQAM 80 Query: 69 KRALQ------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLC 122 K AL Y+PS G LS +++ H P P + + D+ +TSG Q + Sbjct: 81 KDALDSGKYNGYAPSIG---FLSSREEIASYYHCPEA----PLEAK-DVILTSGCSQAID 132 Query: 123 KVFEMIINPGDNVLLDEPAYS--GTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 ++ NPG N+L+ P +S TL + + N+ ++S + D+ Sbjct: 133 LCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEI-----DLKQLEYL 187 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 D K V N +NP G+ + ++I +A + I+ D+ Y + F+ Sbjct: 188 IDEKTA-------CLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSD 240 Query: 241 FRVPTFLSMDVDGRVIRADSFSK-IISSGLRIGFL 274 + ++ D ++ +K + G R+G++ Sbjct: 241 CKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWI 275 >4M2J-A nrPDB Length = 406 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 60/291 (20%), Positives = 108/291 (37%), Gaps = 38/291 (13%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNII---NVASDESGIV 167 + VT GS + + +++ GD V++ E Y GC++ A + I Sbjct: 105 VLVTHGSSEAIALTLNALLHRGDRVVVQEGIYHSLGHYPRAAGCDVAVLPGRAVRDGEID 164 Query: 168 PDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLI 227 PD L +++ T + P +NPTG +L+ + + + E ++ Sbjct: 165 PDVLAGLVT-----------PGTAAVIVNFP--HNPTGVTLSPQGLRALKERTAATGAVL 211 Query: 228 IEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVIL 286 + D + +++ V D G + + SK GLR+G+ PK L+ Sbjct: 212 VWDAATAEIA-HRWEVLADPGAD-GGDTVSYGTLSKTFGLPGLRVGWAVAPKELLTATFP 269 Query: 287 HIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTG--- 343 +TL S +L+ + + H D +I + + LA W+ Sbjct: 270 LRDRTTLFLSPLVELVAERAVR---------HADELIGARAAEARHNLAHLTGWMAAHEE 320 Query: 344 LAEWHVPAAGMF-------LWIKVKGINDVKELIEEKAVKMGVLMLPGNAF 387 L W P G+ L G +V+ E + L++PG AF Sbjct: 321 LVRWTPPEGGVCALPVFRELERAAAGPQEVERFCLELLERHRTLLVPGTAF 371 >2ZJG-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 99/240 (41%), Gaps = 40/240 (16%) Query: 65 EEMMKRAL-----QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMD----LCVTS 115 EE+ K A QY+ G P L+ L L K++ Q Q+D + V Sbjct: 43 EELSKAAFIDNMNQYTRGFGHPALVKALSCLYGKIY----------QRQIDPNEEILVAV 92 Query: 116 GSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVP------D 169 G+ L + +++PGD V++ P Y P+ + +A +P D Sbjct: 93 GAYGSLFNSIQGLVDPGDEVIIMVPFY----DCYEPM----VRMAGAVPVFIPLRSKPTD 144 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLII 228 ++ S W + + K + K + N +NP G T + + I +L K+D L I Sbjct: 145 GMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQELQVIADLCVKHDTLCI 204 Query: 229 EDDPYYFLQF---NKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERV 284 D+ Y +L + ++ T M R I S K S +G ++G+ GP LI+ + Sbjct: 205 SDEVYEWLVYTGHTHVKIATLPGM--WERTITIGSAGKTFSVTGWKLGWSIGPAHLIKHL 262 >2Z61-A nrPDB Length = 370 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 80/339 (23%), Positives = 139/339 (41%), Gaps = 52/339 (15%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPG 132 Y+ S GI EL + +L + I P ++ +T GS GL II+ G Sbjct: 61 HYTDSRGILELREKISELYKDKYKADII---PD----NIIITGGSSLGLFFALSSIIDDG 113 Query: 133 DNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPK 192 D VL+ P Y + LG V D +SL + LS + K N+P Sbjct: 114 DEVLIQNPCYPCYKNFIRFLGAK--PVFCD---FTVESLEEALS----DKTKAIIINSP- 163 Query: 193 FLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD 252 +NP G + +EIYE A + II D+ Y L + + + + D + Sbjct: 164 --------SNPLGEVID----REIYEFAYENIPYIISDEIYNGLVYEG-KCYSAIEFDEN 210 Query: 253 -GRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 + I + FSK+ + +G RIG++ +IE ++ Q + T +Q + + Sbjct: 211 LEKTILINGFSKLYAMTGWRIGYVISNDEIIEAILKLQQNLFISAPTISQYAALKAFEKE 270 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV--PAAGMFLW--IKVKGINDV 366 E ++ +I + ++ +L K++ W V P +++ I G Sbjct: 271 TER----EINSMIKEFDRRRRLVL----KYVKDFG-WEVNNPIGAYYVFPNIGEDGREFA 321 Query: 367 KELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA 405 +L++EK V + PG F S Y+R S++++ Sbjct: 322 YKLLKEKFVA----LTPGIGF---GSKGKNYIRISYANS 353 >3PDX-A nrPDB Length = 402 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 81/378 (21%), Positives = 146/378 (38%), Gaps = 65/378 (17%) Query: 41 PNPNMFPFKTAVITVENGKTIQFGE--------EMMKRALQ------YSPSAGIPELLSW 86 PNPN VI++ G FG + MK AL Y+PS G LS Sbjct: 27 PNPN-----KTVISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIG---YLSS 78 Query: 87 LKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYS--G 144 +++ H P P + + D+ +TSG Q + ++ NPG N+L+ P +S Sbjct: 79 REEVASYYHCPEA----PLEAK-DVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLYR 133 Query: 145 TLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPT 204 TL + + N+ ++S + L+ + S + A V N +NP Sbjct: 134 TLAESMGIEVKLYNLLPEKSWEI--DLKQLESLIDEKTA----------CLVVNNPSNPC 181 Query: 205 GNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSK- 263 G+ + ++I +A + I+ D+ Y + F+ + ++ + ++ +K Sbjct: 182 GSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEPMATLSTNVPILSCGGLAKR 241 Query: 264 IISSGLRIGFLT--------GPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGF 315 + G R+G++ G + I ++ + L P T Q + +L +E + Sbjct: 242 WLVPGWRLGWILIHDRRDIFGNE--IRDGLVKLSQRILGPCTIVQGALKSILQRTPQEFY 299 Query: 316 MAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKG------INDVKEL 369 + F + D A + GL P+ M+L + ++ NDV E Sbjct: 300 ----QDTLSFLKSNADLCYGALSA-IPGLQPVR-PSGAMYLMVGIEMEHFPEFENDV-EF 352 Query: 370 IEEKAVKMGVLMLPGNAF 387 E + V LP F Sbjct: 353 TERLIAEQSVHCLPATCF 370 >3G0T-A nrPDB Length = 437 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 42/93 (45%), Gaps = 9/93 (9%) Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK--------FRVPTFLSMD 250 N NNPT +T E + I ELA K+D ++IED Y+ + F K P+ + Sbjct: 190 NPNNPTWQCMTDEELRIIGELATKHDVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANY- 248 Query: 251 VDGRVIRADSFSKIISSGLRIGFLTGPKPLIER 283 D ++ S +G RIG L L ER Sbjct: 249 TDNYILALSSSKAFSYAGQRIGVLMISGKLYER 281 >3DZZ-A nrPDB Length = 391 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 9/146 (6%) Query: 110 DLCV-TSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVP 168 D CV SG + + +PGD +L+ EP Y+ + G +I+ S ++ Sbjct: 86 DWCVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYSVIEGNGRRVIS-----SDLIY 140 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 ++ + ++ W + K + ++ P +NP G + + E K I EL K+ L+I Sbjct: 141 ENSKYSVN-WADLEEKLATPSVRMMVFCNP--HNPIGYAWSEEEVKRIAELCAKHQVLLI 197 Query: 229 EDDPYYFLQFNKFRVPTFLSMDVDGR 254 D+ + L + ++D D + Sbjct: 198 SDEIHGDLVLTDEDITPAFTVDWDAK 223 >3EZS-A nrPDB Length = 376 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 6/89 (6%) Query: 201 NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK-----FRVPTFLSMDVDGRV 255 NNPTG +L+ E +LA K+DF++I D+ Y + N + V Sbjct: 164 NNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENTPPPSLLEACMLAGNEAFKNV 223 Query: 256 IRADSFSKIISS-GLRIGFLTGPKPLIER 283 + S SK S+ GLR GF+ G L+E+ Sbjct: 224 LVIHSLSKRSSAPGLRSGFIAGDSRLLEK 252 >4IX8-A nrPDB Length = 444 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 58/287 (20%), Positives = 105/287 (36%), Gaps = 44/287 (15%) Query: 2 NYARFITAASAARNPSPIRTMTDIL--SRGPKSMISLAGGLPNPNMFPFKTAVITVE-NG 58 ++ R ++ A R P+ +TD + SR KS + L+ G P TV+ N Sbjct: 36 SFRRIASSKHAQRTLQPLNNLTDNMKPSRSTKSNLRLSIGDP------------TVDGNL 83 Query: 59 KTIQFGEEMMKRALQ------YSPSAGIPELLS-----WLKQLQIKLHNPPTIHYPPSQG 107 KT E M ++ Y P+ G L W + Q K + Sbjct: 84 KTPDIVTEAMVDVVRSGKFNGYPPTVGADNLRQVVSTYWRRFCQTKSRQE-------ALK 136 Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIV 167 ++ +TSG Q + + N GDN+L+ P++ G D S Sbjct: 137 WENVIITSGVSQAIVLALTALCNEGDNILVCAPSFPHYKSVCDSYGIECRYYYLDPSKSW 196 Query: 168 PDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLI 227 LR A ++ + + N +NP G++ + +I + +++ + Sbjct: 197 ECDLR----------AAAGMVDSHTKAFVIINPSNPCGSNFSRAHVSDIIDFCQQHQIPL 246 Query: 228 IEDDPYYFLQFNKFRVPTFLSMDVDG-RVIRADSFSKIISSGLRIGF 273 I D+ Y + N + D + R+I + + G R+G+ Sbjct: 247 ISDEIYAEMVLNNGIFTSVADFDTNVPRLILGGTAKYQVCPGWRVGW 293 >3QGU-A nrPDB Length = 449 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 76/177 (42%), Gaps = 16/177 (9%) Query: 110 DLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 ++ ++ GS+ + ++ +M+ V + +P+Y + + +G + D +G D Sbjct: 134 EIFISDGSKCDIARI-QMMFGSKPTVAVQDPSYPVYVDTSVMMG-----MTGDHNGTGFD 187 Query: 170 SLRDILSRWKPEDAKNPQ----KNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDF 225 + ++ P++ P K T + PN NPTG + T + E+ ARK Sbjct: 188 GIEYMVC--NPDNHFFPDLSKAKRTDIIFFCSPN--NPTGAAATRAQLTELVNFARKNGS 243 Query: 226 LIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPL 280 +++ D Y N T + D I SFSK +G+R+G+ PK L Sbjct: 244 ILVYDAAYALYISNPDCPKTIYEIPGADEVAIETCSFSKYAGFTGVRLGWTVVPKAL 300 >3EI8-A nrPDB Length = 432 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 19/183 (10%) Query: 107 GQMDLCVTSGSQQGLCKVFEMIINPGDNVLL--DEPAYSGTLQSLHPLG-CNIINVASDE 163 G D+ V+ G++ C + + + G NV + +P+Y + S +G N + Sbjct: 118 GDDDVFVSDGAK---CDISRLQVMFGSNVTIAVQDPSYPAYVDSSVIMGQTGQFNTDVQK 174 Query: 164 SGIVPDSLRDILSRWKPEDAKNPQKNTPK----FLYTVPNGNNPTGNSLTSERKKEIYEL 219 G + R PE+ P +T + PN NPTG + T E+ ++ E Sbjct: 175 YGNIE------YMRCTPENGFFPDLSTVGRTDIIFFCSPN--NPTGAAATREQLTQLVEF 226 Query: 220 ARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPK 278 A+K +I+ D Y + F + + SFS +G+R+G+ PK Sbjct: 227 AKKNGSIIVYDSAYAMYMSDDNPRSIFEIPGAEEVAMETASFSNYAGFTGVRLGWTVIPK 286 Query: 279 PLI 281 L+ Sbjct: 287 KLL 289 >5GKO-A nrPDB Length = 671 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 62/157 (39%), Gaps = 36/157 (22%) Query: 115 SGSQQGLCKVFEMIINPGDNVLLDEP-----AYSGT-----LQSLHPLGCNII------N 158 SG QQ + ++N GD +L DEP ++SG L+ L+ G II Sbjct: 155 SGGQQQRVSIARALMNGGDVILADEPTGALDSHSGVEVMRILRELNAAGHTIILVTHDMQ 214 Query: 159 VASDESGIVPDSLRDILS------RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSER 212 VA + + I+ S +I+S E+ K+ P G + + T +R Sbjct: 215 VAKNATRIIEISDGEIISDRPNVPDQSLEEVKSDPDAAPALQNKQKKGKSISAWRSTLDR 274 Query: 213 KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM 249 E +++A L N R+ TFL+M Sbjct: 275 LSEAFQMA--------------LLSMNAHRMRTFLTM 297 >3P1T-A nrPDB Length = 337 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 48/87 (55%), Gaps = 10/87 (11%) Query: 196 TVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRV 255 + N +NPTG +L++ E+ +L ++ L+I++ ++ ++ FR L+ + V Sbjct: 140 VLANPSNPTGQALSA---GELDQLRQRAGKLLIDET---YVDYSSFRARG-LAYGENELV 192 Query: 256 IRADSFSKIIS-SGLRIGFLTGPKPLI 281 R SFSK +GLR+G L GP LI Sbjct: 193 FR--SFSKSYGLAGLRLGALFGPSELI 217 >3TCM-A nrPDB Length = 500 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 102/243 (41%), Gaps = 29/243 (11%) Query: 110 DLCVTSGSQQGLCKVFEMII-NPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVP 168 D+ +T G+ G+ + +++I N D +L+ P Y S+ G ++ +ES Sbjct: 159 DIFLTDGASPGVHLMMQLLIRNEKDGILVPIPQYPLYSASIALHGGALVPYYLNESTGWG 218 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 D+ + + EDA++ N + V N NPTG L E + +I + + +++ Sbjct: 219 LETSDV--KKQLEDARSRGINVRALV--VINPGNPTGQVLAEENQYDIVKFCKNEGLVLL 274 Query: 229 EDDPYY---------FLQFNKFRVPTFLSMDVDGRVIRADSFSK--IISSGLRIGF--LT 275 D+ Y F F K V + + D ++ S SK G R G+ +T Sbjct: 275 ADEVYQENIYVDNKKFHSFKKI-VRSLGYGEEDLPLVSYQSVSKGYYGECGKRGGYFEIT 333 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLH--EWGEEGFMAHVDRVIDFYSNQKDAI 333 G + I I L + Q++ S +++ + +E + + Y +KD I Sbjct: 334 GFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKASDESYAS--------YKAEKDGI 385 Query: 334 LAA 336 LA+ Sbjct: 386 LAS 388 >3ASB-A nrPDB Length = 400 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Query: 201 NNPTGNSLTSERKKEIYELARKYDFLIIEDDPY-YFLQFNKFRVPTFLSMDVDGRVIRAD 259 NNPTG L ++ + I A +++ LI+ D Y F+ F D I + Sbjct: 173 NNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIPDARFCAIEIN 232 Query: 260 SFSKIIS-SGLRIGFLTGPKPL 280 SFSK + +G+R+G+ P+ L Sbjct: 233 SFSKPLGFAGIRLGWTVIPQEL 254 >1UU1-A nrPDB Length = 335 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 12/99 (12%) Query: 197 VPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVI 256 +PN NNPTG+ E EI + + F+ + D+ YY +F+ FL + VI Sbjct: 144 IPNPNNPTGHVFERE---EIERILKTGAFVAL-DEAYY--EFHGESYVDFLKKYENLAVI 197 Query: 257 RADSFSKIIS-SGLRIGFLTGPKPLIE---RVILHIQVS 291 R +FSK S + R+G++ + I+ RV L VS Sbjct: 198 R--TFSKAFSLAAQRVGYVVASEKFIDAYNRVRLPFNVS 234 >5LJ6-A nrPDB Length = 664 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 25/134 (18%) Query: 78 AGIPE--LLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNV 135 AG+P+ L KQL KL P+Q SG QQ + ++N G+ + Sbjct: 133 AGMPQSQRLERAKQLLEKLGLGDKWQNKPNQ-------LSGGQQQRVSIARALMNGGEII 185 Query: 136 LLDEP-----AYSG-----TLQSLHPLGCNIINVASDE------SGIVPDSLRDILSRWK 179 L D+P ++SG L+ LH G II V D+ + I+ +I+S + Sbjct: 186 LADQPTGALDSHSGENVMEILRQLHEEGHTIIMVTHDKHIAASANRIIEIKDGEIISDTQ 245 Query: 180 PEDAKNPQKNTPKF 193 K+ KN F Sbjct: 246 KRQVKSAVKNPSVF 259 >3NNK-A nrPDB Length = 411 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 35/161 (21%), Positives = 61/161 (37%), Gaps = 23/161 (14%) Query: 81 PELLSWLKQLQIKLHNPPTIHYP-----------PSQGQMDLCVTSGSQQGLCKVFEMII 129 P +L + I ++P HY ++ + + V S+ G+ + I Sbjct: 26 PRVLRAMSSQLIGQYDPAMTHYMNEVMALYRGVFRTENRWTMLVDGTSRAGIEAILVSAI 85 Query: 130 NPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKN 189 PGD VL+ P + L C I E + ++ + + EDA ++ Sbjct: 86 RPGDKVLV--PVFG----RFGHLLCEIARRCRAEVHTIEVPWGEVFTPDQVEDA--VKRI 137 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 P+ L TV + T + E+ E+ R+YD L D Sbjct: 138 RPRLLLTVQGDTSTT----MLQPLAELGEICRRYDALFYTD 174 >5XTI-AF nrPDB Length = 106 Score = 29.3 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 4/54 (7%) Query: 334 LAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAF 387 ++A+ KWL G+ +W+ AAG G+ + E++ VK + LP N + Sbjct: 2 VSASGKWLDGIRKWYYNAAGF----NKLGLMRDDTIYEDEDVKEAIRRLPENLY 51 >3EUC-A nrPDB Length = 367 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 8/87 (9%) Query: 201 NNPTGNSLTSERKKEIYELARK--YDFLIIEDDPYYFLQFNKFRVPTFLSMDVD-GRVIR 257 NNPTGN + + I A+ L++ D+ Y F +++S D G ++ Sbjct: 167 NNPTGNLFDAADMEAIVRAAQGSVCRSLVVVDEAY-----QPFAQESWMSRLTDFGNLLV 221 Query: 258 ADSFSKIISSGLRIGFLTGPKPLIERV 284 + SK+ +G+R+G++ G +E++ Sbjct: 222 MRTVSKLGLAGIRLGYVAGDPQWLEQL 248 >3MEB-A nrPDB Length = 448 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 33/78 (42%), Gaps = 4/78 (5%) Query: 201 NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTF---LSMDVDGRVIR 257 +NP+G T + KE+ + ++ + D Y F F + +D V+ Sbjct: 212 HNPSGIDFTEAQWKELLPIMKEKKHIAFFDSAYQGFATGSFEADAFAVRMFVDAGVEVLV 271 Query: 258 ADSFSKIIS-SGLRIGFL 274 A SFSK G RIG L Sbjct: 272 AQSFSKNFGLYGERIGCL 289 >5X5H-A nrPDB Length = 392 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 10/24 (41%), Positives = 17/24 (70%) Query: 124 VFEMIINPGDNVLLDEPAYSGTLQ 147 +F +I+ PGD+++L AY GT + Sbjct: 89 LFRIILKPGDHIVLGNDAYGGTYR 112 >3K53-A nrPDB Length = 271 Score = 28.5 bits (62), Expect = 6.5, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 38/95 (40%), Gaps = 6/95 (6%) Query: 6 FITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGE 65 + NP R DI R K + L G P +P + + K +Q E Sbjct: 162 LMAEGKVTTNPIIPRYDEDI-EREIKHISELLRGTPLAEKYPIRWLAL-----KLLQRDE 215 Query: 66 EMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTI 100 E++K L+Y + E+L + +L+ K P I Sbjct: 216 EVIKLVLKYLGQEKMDEILKHISELEEKYKRPLDI 250 >5W1B-A nrPDB Length = 467 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 7/100 (7%) Query: 153 GCNIINVASD---ESGIVPDSLRDI-LSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSL 208 GC IN+ ++ +S D D + + K A++ N + TV N+ G + Sbjct: 143 GCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTV-TCNSAGGQPV 201 Query: 209 TSERKKEIYELARKYDFLIIEDDPYYF--LQFNKFRVPTF 246 + KE+YE+A+++ ++ D + F K R P + Sbjct: 202 SMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKY 241 >3QV0-A nrPDB Length = 227 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 1/45 (2%) Query: 367 KELIEEKAVKMGVLM-LPGNAFYVDSSAPSPYLRASFSSASPEQM 410 KE E AV +LM L +FYVDS+ P P + A+ + ++ ++ Sbjct: 120 KESASEPAVSFELLMNLQEGSFYVDSATPYPSVDAALNQSAEAEI 164 >1BCC-F nrPDB Length = 109 Score = 27.7 bits (60), Expect = 8.9, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 27/54 (50%), Gaps = 4/54 (7%) Query: 334 LAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAF 387 ++A+ +WL G+ +W+ AAG + G+ + E VK + LP N + Sbjct: 6 VSASSRWLEGIRKWYYNAAGFNKY----GLMRDDTIYENDDVKEAIRRLPENLY 55 >1M4N-A nrPDB Length = 435 Score = 27.7 bits (60), Expect = 9.2, Method: Compositional matrix adjust. Identities = 63/338 (18%), Positives = 129/338 (38%), Gaps = 45/338 (13%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH-PLGCNIINVASDESGIVPD 169 L +T+G+ + +PG+ VL+ P Y G + L G I+ + S Sbjct: 114 LVLTAGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSSNGFQI 173 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIE 229 + + ++ + +N + V N +NP G ++T + +I Sbjct: 174 TETALEEAYQEAEKRNLRVKG----VLVTNPSNPLGTTMTRNELYLLLSFVEDKGIHLIS 229 Query: 230 DDPYYFLQFNKFRVPTFLSM-------------DVDGRVIRADSFSKIIS-SGLRIGFLT 275 D+ Y F P+F+S+ +V RV S SK + G R+G + Sbjct: 230 DEIY---SGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVGAIY 286 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILA 335 ++ + L S L+ + L + + ++A + + QK Sbjct: 287 SNDDMVVAAATKMSSFGLVSSQTQHLLSAMLSDKKLTKNYIAENHKRLK--QRQK----- 339 Query: 336 AADKWLTGLAEWHVPA----AGMFLWIKVKGI---NDVK---ELIEEKAVKMGVLMLPGN 385 K ++GL + + AG+F W+ ++ + N + EL ++ ++ + + PG+ Sbjct: 340 ---KLVSGLQKSGISCLNGNAGLFCWVDMRHLLRSNTFEAEMELWKKIVYEVHLNISPGS 396 Query: 386 AFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 + + + R F++ +D+A Q L + E Sbjct: 397 SCHCTEPG---WFRVCFANLPERTLDLAMQRLKAFVGE 431 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4GDY-A nrPDB 539 e-153 3AV7-A nrPDB 387 e-108 1X0M-A nrPDB 383 e-107 1WST-A nrPDB 375 e-104 2ZC0-A nrPDB 344 6e-95 6HNB-A nrPDB 341 4e-94 4JE5-A nrPDB 332 1e-91 1VP4-A nrPDB 328 2e-90 1GDE-A nrPDB 309 2e-84 2ZYJ-A nrPDB 304 7e-83 1GC4-A nrPDB 290 1e-78 1J32-A nrPDB 288 4e-78 4MY5-A nrPDB 277 9e-75 5WMH-A nrPDB 276 2e-74 6F77-B nrPDB 270 6e-73 1O4S-A nrPDB 270 6e-73 6HNV-A nrPDB 270 8e-73 6F35-A nrPDB 266 1e-71 1U08-A nrPDB 265 2e-71 2Z61-A nrPDB 252 3e-67 4WP0-A nrPDB 248 2e-66 3FVS-A nrPDB 248 2e-66 2ZJG-A nrPDB 247 7e-66 1V2E-A nrPDB 244 5e-65 5YHV-A nrPDB 243 9e-65 3H14-A nrPDB 243 1e-64 1XI9-A nrPDB 238 3e-63 2O1B-A nrPDB 230 9e-61 2X5D-A nrPDB 228 4e-60 2GB3-A nrPDB 225 2e-59 3B46-A nrPDB 223 1e-58 3PDX-A nrPDB 222 3e-58 3DYD-A nrPDB 220 6e-58 3OP7-A nrPDB 215 3e-56 2O0R-A nrPDB 213 1e-55 4CVQ-A nrPDB 201 4e-52 3G7Q-A nrPDB 195 3e-50 3JTX-A nrPDB 193 9e-50 3IF2-A nrPDB 191 4e-49 5IWQ-A nrPDB 188 3e-48 3NRA-A nrPDB 187 7e-48 3EZ1-A nrPDB 184 7e-47 4M2J-A nrPDB 182 2e-46 5X03-B nrPDB 172 3e-43 4N0B-A nrPDB 171 5e-43 2DOU-A nrPDB 164 5e-41 Sequences not found previously or not previously below threshold: 1YIY-A nrPDB 209 2e-54 1BW0-A nrPDB 172 2e-43 4IX8-A nrPDB 164 6e-41 3ELE-A nrPDB 164 8e-41 1IAY-A nrPDB 146 2e-35 3ASB-A nrPDB 140 1e-33 1M4N-A nrPDB 137 9e-33 5C6U-A nrPDB 133 2e-31 3QGU-A nrPDB 129 2e-30 3B1C-A nrPDB 127 1e-29 4FL0-A nrPDB 126 2e-29 3L8A-A nrPDB 122 4e-28 4DQ6-A nrPDB 121 8e-28 3EI8-A nrPDB 118 4e-27 3DZZ-A nrPDB 118 5e-27 5Z0Q-C nrPDB 116 2e-26 3EZS-A nrPDB 114 6e-26 3IHJ-A nrPDB 114 8e-26 3TCM-A nrPDB 114 9e-26 3T32-A nrPDB 112 3e-25 1D2F-A nrPDB 109 3e-24 1C7O-A nrPDB 107 8e-24 3FDB-A nrPDB 106 2e-23 4R2N-A nrPDB 104 7e-23 1IJI-A nrPDB 98 5e-21 2X5F-A nrPDB 98 7e-21 4EMY-A nrPDB 96 2e-20 3EUC-A nrPDB 95 6e-20 3LY1-A nrPDB 94 2e-19 3CQ5-A nrPDB 93 2e-19 1UU1-A nrPDB 91 1e-18 3FKD-A nrPDB 90 1e-18 2ZY2-A nrPDB 89 2e-18 3FDD-A nrPDB 89 3e-18 2ZY3-A nrPDB 89 4e-18 3F6T-A nrPDB 87 1e-17 3FSL-A nrPDB 86 4e-17 3G0T-A nrPDB 85 5e-17 3HDO-A nrPDB 85 6e-17 3GET-A nrPDB 84 1e-16 3RQ1-A nrPDB 84 2e-16 3FFH-A nrPDB 82 4e-16 4RAE-A nrPDB 82 5e-16 6C3C-A nrPDB 81 1e-15 1LC8-A nrPDB 79 2e-15 4WBT-A nrPDB 78 7e-15 3FTB-A nrPDB 77 2e-14 5DJ3-A nrPDB 76 2e-14 4RKC-A nrPDB 73 3e-13 4WD2-A nrPDB 73 3e-13 3P1T-A nrPDB 71 8e-13 4F5M-A nrPDB 69 3e-12 3BWN-A nrPDB 68 9e-12 1AY8-A nrPDB 63 3e-10 4PIW-A nrPDB 62 4e-10 3TQX-A nrPDB 62 4e-10 4W5K-A nrPDB 61 7e-10 6BLG-A nrPDB 61 9e-10 1FC4-A nrPDB 59 5e-09 4K2M-A nrPDB 58 6e-09 3DR4-A nrPDB 58 9e-09 4EFF-A nrPDB 58 1e-08 2OGE-A nrPDB 57 2e-08 3PD6-B nrPDB 56 2e-08 3NYS-A nrPDB 56 3e-08 1M6S-A nrPDB 56 5e-08 1SFF-A nrPDB 55 7e-08 3II0-A nrPDB 54 1e-07 1MDZ-A nrPDB 53 2e-07 2CST-A nrPDB 53 3e-07 5I92-A nrPDB 53 4e-07 3UWC-A nrPDB 52 4e-07 6EZL-A nrPDB 52 5e-07 2C81-A nrPDB 52 6e-07 4ADC-A nrPDB 51 1e-06 2CFB-A nrPDB 51 1e-06 1B9H-A nrPDB 50 2e-06 1TAR-A nrPDB 50 2e-06 5W70-A nrPDB 49 3e-06 4GSA-A nrPDB 49 3e-06 4WB0-B nrPDB 49 4e-06 4ATP-A nrPDB 49 4e-06 2X8U-A nrPDB 48 8e-06 5K8B-A nrPDB 48 9e-06 2GMS-A nrPDB 47 1e-05 2HOR-A nrPDB 47 1e-05 3NNK-A nrPDB 47 1e-05 2E54-A nrPDB 47 2e-05 3WGB-A nrPDB 47 2e-05 4QGR-A nrPDB 47 2e-05 1YAA-A nrPDB 47 2e-05 5TON-A nrPDB 47 2e-05 5JAY-A nrPDB 46 3e-05 5LL2-A nrPDB 46 4e-05 5VIU-A nrPDB 46 4e-05 3BB8-A nrPDB 46 4e-05 3BS8-A nrPDB 45 8e-05 4H51-A nrPDB 44 1e-04 6ONN-A nrPDB 44 1e-04 4E3Q-A nrPDB 44 1e-04 3MEB-A nrPDB 44 1e-04 3VK2-A nrPDB 44 2e-04 5Z8A-A nrPDB 43 2e-04 5W1B-A nrPDB 43 2e-04 2E7J-A nrPDB 42 4e-04 6CBN-A nrPDB 42 5e-04 3K7Y-A nrPDB 41 9e-04 5WT2-A nrPDB 41 0.001 2E7U-A nrPDB 41 0.001 6CJB-A nrPDB 40 0.002 4BMK-A nrPDB 39 0.003 5G4J-A nrPDB 39 0.004 2DKJ-A nrPDB 39 0.004 5IJG-A nrPDB 39 0.005 3GBX-A nrPDB 39 0.006 4IYO-A nrPDB 38 0.007 3QI6-A nrPDB 38 0.008 3ECD-A nrPDB 38 0.008 5X5H-A nrPDB 38 0.010 3MC8-A nrPDB 37 0.012 6FYQ-A nrPDB 37 0.012 2VYC-A nrPDB 37 0.018 4GRX-A nrPDB 36 0.028 5VMB-A nrPDB 36 0.032 3ISL-A nrPDB 36 0.033 3HMU-A nrPDB 36 0.036 3NDN-A nrPDB 36 0.038 3G8M-A nrPDB 36 0.038 3WY7-A nrPDB 36 0.042 1Z7D-A nrPDB 36 0.043 4LHD-A nrPDB 36 0.045 5U24-A nrPDB 36 0.049 1VJO-A nrPDB 36 0.049 5TSU-A nrPDB 35 0.050 6GIO-D nrPDB 35 0.050 4BA4-A nrPDB 35 0.055 3MAF-B nrPDB 35 0.082 6G4F-A nrPDB 34 0.089 3I5T-A nrPDB 34 0.099 2C44-A nrPDB 34 0.10 1IUG-A nrPDB 34 0.11 3NTJ-A nrPDB 34 0.13 2EO5-A nrPDB 34 0.13 5XX1-A nrPDB 34 0.14 2CH1-A nrPDB 34 0.14 5GQO-A nrPDB 34 0.15 5EAV-A nrPDB 34 0.16 4OTL-A nrPDB 34 0.18 3BC8-A nrPDB 33 0.22 4L0O-H nrPDB 33 0.23 1IBJ-A nrPDB 33 0.24 3AXS-A nrPDB 33 0.24 4U1T-A nrPDB 33 0.24 5N3U-B nrPDB 33 0.29 5KR3-A nrPDB 33 0.30 5TXT-B nrPDB 33 0.30 6IO1-A nrPDB 32 0.33 3HL2-A nrPDB 32 0.35 2ZUK-A nrPDB 32 0.35 3GJU-A nrPDB 32 0.35 5YKR-A nrPDB 32 0.43 5KQW-A nrPDB 32 0.47 5LH9-A nrPDB 32 0.55 1ORD-A nrPDB 32 0.57 2CB1-A nrPDB 32 0.69 6JEQ-A nrPDB 32 0.71 5KQT-A nrPDB 31 0.78 5GHG-A nrPDB 31 0.86 5KR6-A nrPDB 31 0.91 5M46-A nrPDB 31 1.0 5UM8-G nrPDB 31 1.1 3N5M-A nrPDB 31 1.2 5OGX-A nrPDB 31 1.4 5KR5-A nrPDB 31 1.4 4G89-A nrPDB 30 1.6 2HUU-A nrPDB 30 1.7 6ERK-A nrPDB 30 1.7 4RIT-B nrPDB 30 1.8 4WXB-A nrPDB 30 1.9 3WKR-A nrPDB 30 2.1 6GWI-A nrPDB 30 2.2 2IAE-B nrPDB 30 2.6 1UA7-A nrPDB 29 2.9 2JAK-A nrPDB 29 3.0 5SW9-A nrPDB 29 3.1 2IST-A nrPDB 29 3.2 2FQ6-A nrPDB 29 3.3 4OBV-D nrPDB 29 3.6 2CY8-A nrPDB 29 3.6 1VK3-A nrPDB 29 3.7 5KQU-A nrPDB 29 4.4 5GP4-C nrPDB 29 5.3 1WA5-C nrPDB 29 5.4 5XVH-A nrPDB 29 5.8 5LUC-A nrPDB 29 6.0 >4GDY-A nrPDB Length = 439 Score = 539 bits (1387), Expect = e-153, Method: Composition-based stats. Identities = 423/425 (99%), Positives = 423/425 (99%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT Sbjct: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG Sbjct: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP Sbjct: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN Sbjct: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNS 240 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ Sbjct: 241 GRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV Sbjct: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 Query: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL Sbjct: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 Query: 421 IKESL 425 IKESL Sbjct: 421 IKESL 425 >3AV7-A nrPDB Length = 448 Score = 387 bits (993), Expect = e-108, Method: Composition-based stats. Identities = 124/424 (29%), Positives = 216/424 (50%), Gaps = 26/424 (6%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTI 61 + RF + + S +R + ++ +ISLAGGLPNP FP + + + Sbjct: 49 DVERFFSKKALEMRASEVRELLKLVETS--DIISLAGGLPNPKTFPKEIIRDIL-----V 101 Query: 62 QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL 121 + E+ +ALQY + G L L + K + D+ +TSGSQQ L Sbjct: 102 EIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGIS--------QDNDIMITSGSQQAL 153 Query: 122 CKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 + + +NPGD V+++ P Y LQ+ + I + D+ G+ + L + L K + Sbjct: 154 DLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDEGMKVEILEEKLKELKSQ 213 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 K K +YTVP NP G ++ +R+K + ELA +YDF+++EDDPY L+++ Sbjct: 214 GKK------VKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGN 267 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 ++D +GRVI +FSKI++ G RIG++ G +I ++ + Q + L + F Q+ Sbjct: 268 PEKKIKALDNEGRVIYLGTFSKILAPGFRIGWMVGDPGIIRKMEIAKQSTDLCTNVFGQV 327 Query: 302 MISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK 361 + + + E H+ + FY ++DA+L A ++++ +W P GMF+W+ + Sbjct: 328 VAWRYVDGGYLE---KHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVTLP 384 Query: 362 GINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 D K+++ E+A+K GV +PG AFY + +R +F+ +++ + LA+ I Sbjct: 385 DGIDSKKML-ERAIKKGVAYVPGEAFYAHRDVKN-TMRLNFTYVDEDKIMEGIKRLAETI 442 Query: 422 KESL 425 KE L Sbjct: 443 KEEL 446 >1X0M-A nrPDB Length = 403 Score = 383 bits (983), Expect = e-107, Method: Composition-based stats. Identities = 124/424 (29%), Positives = 216/424 (50%), Gaps = 26/424 (6%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTI 61 + RF + + S +R + ++ +ISLAGGLPNP FP + + + Sbjct: 4 DVERFFSKKALEMRASEVRELLKLVETS--DIISLAGGLPNPKTFPKEIIRDIL-----V 56 Query: 62 QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL 121 + E+ +ALQY + G L L + K + D+ +TSGSQQ L Sbjct: 57 EIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGIS--------QDNDIMITSGSQQAL 108 Query: 122 CKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 + + +NPGD V+++ P Y LQ+ + I + D+ G+ + L + L K + Sbjct: 109 DLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLDDEGMKVEILEEKLKELKSQ 168 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 K K +YTVP NP G ++ +R+K + ELA +YDF+++EDDPY L+++ Sbjct: 169 GKK------VKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGN 222 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 ++D +GRVI +FSKI++ G RIG++ G +I ++ + Q + L + F Q+ Sbjct: 223 PEKKIKALDNEGRVIYLGTFSKILAPGFRIGWMVGDPGIIRKMEIAKQSTDLCTNVFGQV 282 Query: 302 MISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK 361 + + + E H+ + FY ++DA+L A ++++ +W P GMF+W+ + Sbjct: 283 VAWRYVDGGYLE---KHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVTLP 339 Query: 362 GINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 D K+++ E+A+K GV +PG AFY + +R +F+ +++ + LA+ I Sbjct: 340 DGIDSKKML-ERAIKKGVAYVPGEAFYAHRDVKN-TMRLNFTYVDEDKIMEGIKRLAETI 397 Query: 422 KESL 425 KE L Sbjct: 398 KEEL 401 >1WST-A nrPDB Length = 417 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 123/425 (28%), Positives = 214/425 (50%), Gaps = 25/425 (5%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 +N+ F + + S +R + ++ +ISLAGGLP P FP +T Sbjct: 13 INFDSFFSEKAMLMKASEVRELLKLVETS--DVISLAGGLPAPETFPVETIKKIA----- 65 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 ++ EE +ALQY + G L L + K ++ P ++++ +GSQQ Sbjct: 66 VEVLEEHADKALQYGTTKGFTPLRLALARWMEKRYDIP-------MSKVEIMTVAGSQQA 118 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L + + +NPGD ++++ P Y +Q+ I++ D+ G+ D L + L + Sbjct: 119 LDLIGRVFLNPGDPIVVEAPTYLAAIQAFKYYDPEFISIPLDDKGMRVDLLEEKLEELRK 178 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 + + K +YTV NP G +++ +R+K++ ELA +YDFLI+ED PY L+++ Sbjct: 179 QGKR------VKIVYTVSTFQNPAGVTMSVDRRKKLLELANEYDFLIVEDGPYSELRYSG 232 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 P D GRVI +FSKI++ G RIG++ LI ++ + Q L +TF Q Sbjct: 233 EPTPPIKHFDDYGRVIYLGTFSKILAPGFRIGWVAAHPHLIRKMEIAKQSIDLCTNTFGQ 292 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 + + + + H+ ++I+FY ++DA+L A ++++ EW P GMF+ + + Sbjct: 293 AIAWKYVENGYLD---EHIPKIIEFYKPRRDAMLEALEEYMPEGVEWTKPEGGMFVRVTL 349 Query: 361 KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 D K L+ E+AV GV +PG AF+V + +R +F+ E + + LA+ Sbjct: 350 PEGIDTK-LMMERAVAKGVAYVPGEAFFVHRDKKN-TMRLNFTYVPEETIREGVRRLAET 407 Query: 421 IKESL 425 IKE + Sbjct: 408 IKEEM 412 >2ZC0-A nrPDB Length = 407 Score = 344 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 120/429 (27%), Positives = 210/429 (48%), Gaps = 28/429 (6%) Query: 1 MNYARFITAASAARNPSPI----RTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVE 56 M+Y +++ + S + + +++ +G K +ISLA G P+P + P Sbjct: 1 MDYTKYLAGRANWIKGSALADVMKKASELQKKGVK-LISLAAGDPDPELIPRAVL----- 54 Query: 57 NGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 G+ + E +++ Y+P+ GIPEL L K + P ++ +T G Sbjct: 55 -GEIAKEVLEKEPKSVMYTPANGIPELREELAAFLKKYD---HLEVSPE----NIVITIG 106 Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 L + ++I+PGD V+ + P+Y TL + LG I V D G+ D L + + Sbjct: 107 GTGALDLLGRVLIDPGDVVITENPSYINTLLAFEQLGAKIEGVPVDNDGMRVDLLEEKIK 166 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 K + K K +YT+P G NP G +++ ER+K + E+A KYD LIIED Y F+ Sbjct: 167 ELKAKGQK------VKLIYTIPTGQNPMGVTMSMERRKALLEIASKYDLLIIEDTAYNFM 220 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 ++ + ++D +GRVI A + SK++ +G RIG++ ++++V++ Q Sbjct: 221 RYEGGDIVPLKALDNEGRVIVAGTLSKVLGTGFRIGWIIAEGEILKKVLMQKQPIDFCAP 280 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFL 356 +Q + + L E + H++ + Y ++D +L A + L AE+ P AGMF+ Sbjct: 281 AISQYIALEYLKRGYFEKY--HLEGALLGYKEKRDIMLKALENHLPN-AEFTKPIAGMFV 337 Query: 357 WIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQV 416 + D E + GV+++PG FY D S + +R +FS S E++ + + Sbjct: 338 MFFLPEGADGISFANELMEREGVVVVPGKPFYTDESGKNA-IRLNFSRPSKEEIPIGIKK 396 Query: 417 LAQLIKESL 425 LA+L KE Sbjct: 397 LAKLYKEKF 405 >6HNB-A nrPDB Length = 491 Score = 341 bits (874), Expect = 4e-94, Method: Composition-based stats. Identities = 145/496 (29%), Positives = 248/496 (50%), Gaps = 89/496 (17%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKT----------- 50 + ++ S AR SP++ + + + L GGLP + FPF+ Sbjct: 11 DLTHLLSNESKARQTSPLKGIFKYYKQ--PGITFLGGGLPLSDYFPFEKVTADIPTPSFS 68 Query: 51 ----AVITVENGKTIQFGEEMMK---------RALQYSPSAGIPELLSWLKQLQIKLHNP 97 A I EN TI+ ++ R+LQY + G+PE L ++K+ +H Sbjct: 69 GGIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEHTDMVHKV 128 Query: 98 PTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNII 157 P D+ V+ G+ + + GD +L++E +S L+S + G N + Sbjct: 129 P-------YENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESANGQGVNTV 181 Query: 158 NVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIY 217 V DE GI+P+ L +++SRW N PKFLYT+ G NPTG+SL++ER+K+IY Sbjct: 182 PVTMDEFGIIPEKLEELMSRWVG--------NKPKFLYTICTGQNPTGSSLSAERRKQIY 233 Query: 218 ELARKYDFLIIEDDPYYFLQ---------------------FNKFRVPTFLSMDVDGRVI 256 ++A KYDFLIIED+PYYFLQ F K VP+F+S+DV+GRV+ Sbjct: 234 DIACKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVV 293 Query: 257 RADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFM 316 R DSFSK+++ GLR+G++ G K L+ER + +VS +PS F++ + + LL +WG G++ Sbjct: 294 RLDSFSKVLAPGLRLGWIVGQKDLLERYVRLHEVSVQNPSGFSEALANALLRKWGHSGYL 353 Query: 317 AHVDRVIDFYSNQKDAILAAADKWLT-GLAEWHVPAAGMFLWIKVK------------GI 363 + + Y++++D + A D+++ ++ ++ P AGMF + + Sbjct: 354 DWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEFLEDP 413 Query: 364 NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP--------------YLRASFSSASPEQ 409 V+ + E+A+K G L+ PG+ F + + P + R ++++ +Q Sbjct: 414 LKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQ 473 Query: 410 MDVAFQVLAQLIKESL 425 + V + + ++ Sbjct: 474 LVVGLEKFGKAVRAEF 489 >4JE5-A nrPDB Length = 503 Score = 332 bits (851), Expect = 1e-91, Method: Composition-based stats. Identities = 137/504 (27%), Positives = 234/504 (46%), Gaps = 95/504 (18%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVIT------- 54 +++ + + AR PSP++T + ++I L GGLP + FP+ + Sbjct: 11 DFSYLFSDETNARKPSPLKTCIHLFQD--PNIIFLGGGLPLKDYFPWDNLSVDSPKPPFP 68 Query: 55 ------VENGKTIQF--------------GEEMMKRALQYSPSAGIPELLSWLKQLQIKL 94 ++ I++ + + RALQY SAG PELL++++ + Sbjct: 69 QGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKII 128 Query: 95 HNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGC 154 H+ D+ T+G+ + N GD +L++ ++S +L S G Sbjct: 129 HDLK-------YKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGV 181 Query: 155 NIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKK 214 V D GI+P+ L ++ W P K PK LYT+P G NPTG S+ RK+ Sbjct: 182 ITFPVPIDADGIIPEKLAKVMENWTPGAPK------PKLLYTIPTGQNPTGTSIADHRKE 235 Query: 215 EIYELARKYDFLIIEDDPYYFLQ------------------------FNKFRVPTFLSMD 250 IY++A+KYDFLI+ED+PYYFLQ F K TFLS+D Sbjct: 236 AIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLD 295 Query: 251 VDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 +GRVIR DSFSK+++ G R+G++TG +++ + +++ P+ F Q++++ L W Sbjct: 296 TEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRW 355 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWH--VPAAGMFLWI---------- 358 G++G++ + + Y+ ++D + A K+L + P AGMF + Sbjct: 356 GQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEF 415 Query: 359 KVKGINDVKEL---IEEKAVKMGVLMLPGNAFYVDSSAPSP--------------YLRAS 401 K K +D +L + K V+ GVL++PG+ F + P + R + Sbjct: 416 KTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGT 475 Query: 402 FSSASPEQMDVAFQVLAQLIKESL 425 +++ SPE++ + L + E Sbjct: 476 YAAVSPEKLTEGLKRLGDTLYEEF 499 >1VP4-A nrPDB Length = 425 Score = 328 bits (841), Expect = 2e-90, Method: Composition-based stats. Identities = 110/425 (25%), Positives = 197/425 (46%), Gaps = 24/425 (5%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 +N I+ S IR + + K IS GG+P+P FP K + Sbjct: 15 VNLEGKISKIGQNMKSSIIREILKFAAD--KDAISFGGGVPDPETFPRKELAEIAK---- 68 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 + E+ LQYS + G P L + +L +++ + + +L T GSQQ Sbjct: 69 -EIIEKEYHYTLQYSTTEGDPVLKQQILKLLERMYGITGLD------EDNLIFTVGSQQA 121 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L + ++ ++ +LD+PAY G + + N + V ++ G+ + L LS + Sbjct: 122 LDLIGKLFLDDESYCVLDDPAYLGAINAFRQYLANFVVVPLEDDGMDLNVLERKLSEFD- 180 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 KN + KF+Y V N +NP G + + E++K + E+A KYD I+EDDPY L++ Sbjct: 181 ---KNGKIKQVKFIYVVSNFHNPAGVTTSLEKRKALVEIAEKYDLFIVEDDPYGALRYEG 237 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 V + RV+ ++FSK+++ GLRIG + G K I +++ Q + L Sbjct: 238 ETVDPIFKIGGPERVVLLNTFSKVLAPGLRIGMVAGSKEFIRKIVQAKQSADLCSPAITH 297 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGL--AEWHVPAAGMFLWI 358 + ++ L + + + I+ Y ++ +L A +++ + + +W G+F+W+ Sbjct: 298 RLAARYLERY---DLLEQLKPTIELYRRKRTVMLNALEEYFSDIPGVKWVKSEGGLFIWL 354 Query: 359 KVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLA 418 + D E+ E A + V +PG F V PSP +R SF E++ + L Sbjct: 355 TLPEGFDTWEMF-EYAKRKKVFYVPGRVFKV-YDEPSPSMRLSFCLPPDEKIVEGIKRLR 412 Query: 419 QLIKE 423 +++ E Sbjct: 413 EVVLE 417 >1GDE-A nrPDB Length = 389 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 95/420 (22%), Positives = 177/420 (42%), Gaps = 40/420 (9%) Query: 7 ITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEE 66 ++ + S IR + DI + G K +ISL G P+ F T E K E Sbjct: 3 LSDRLELVSASEIRKLFDIAA-GMKDVISLGIGEPD-----FDTPQHIKEYAK-----EA 51 Query: 67 MMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFE 126 + K Y P+ G+ EL + + KL I P + ++ V G+ Q Sbjct: 52 LDKGLTHYGPNIGLLELREAIAE---KLKKQNGIEADP---KTEIMVLLGANQAFLMGLS 105 Query: 127 MIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNP 186 + G+ VL+ PA+ ++ G + V + E D R + K Sbjct: 106 AFLKDGEEVLIPTPAFVSYAPAVILAGGKPVEVPTYEE----DEFRLNVDELKKYVTDKT 161 Query: 187 QKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTF 246 + + + NPTG LT + +EI + ++D ++I D+ Y ++ R + Sbjct: 162 RA------LIINSPCNPTGAVLTKKDLEEIADFVVEHDLIVISDEVYEHFIYDDARHYSI 215 Query: 247 LSMD-VDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMIS 304 S+D + R I + FSK + +G R+GF+ P +IER++ + P TF Q + Sbjct: 216 ASLDGMFERTITVNGFSKTFAMTGWRLGFVAAPSWIIERMVKFQMYNATCPVTFIQYAAA 275 Query: 305 QLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGIN 364 + L +E V+ + Y ++ + ++ GL P +++ +++ Sbjct: 276 KALK---DERSWKAVEEMRKEYDRRRKLVWKRLNEM--GLPTV-KPKGAFYIFPRIRDTG 329 Query: 365 DVKELIEEK-AVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 + E + V ++PG+AF A Y+R S+++A E+++ A + +++KE Sbjct: 330 LTSKKFSELMLKEARVAVVPGSAF---GKAGEGYVRISYATAY-EKLEEAMDRMERVLKE 385 >2ZYJ-A nrPDB Length = 397 Score = 304 bits (777), Expect = 7e-83, Method: Composition-based stats. Identities = 111/425 (26%), Positives = 201/425 (47%), Gaps = 40/425 (9%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 ++++ + S IR + + R ++S AGGLP P +FP + A Sbjct: 4 LSWSEAFGKGAGRIQASTIRELLKLTQR--PGILSFAGGLPAPELFPKEEAAEAAAR--- 58 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 E + ALQYSP+ G L +++ + I P ++ +T+GSQQ Sbjct: 59 --ILREKGEVALQYSPTEGYAPLRAFVAEW---------IGVRPE----EVLITTGSQQA 103 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L V ++ ++ G VLL+ P+Y G +Q+ G + V + E G D+L ++L R + Sbjct: 104 LDLVGKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDALEEVLKRER- 162 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK 240 P+FLY +P+ NPTG +K + ++ + +++EDD Y L F + Sbjct: 163 ----------PRFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDAYRELYFGE 212 Query: 241 FRVPTFLSMDVDG---RVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPST 297 R+P+ + + VI SFSK++S GLR+ F +++++ Q + LH Sbjct: 213 ARLPSLFELAREAGYPGVIYLGSFSKVLSPGLRVAFAVAHPEALQKLVQAKQGADLHTPM 272 Query: 298 FNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLW 357 NQ+++ +LL EGF ++RV Y + A+L A D+ + + P GMF+W Sbjct: 273 LNQMLVHELLK----EGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVW 328 Query: 358 IKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVL 417 +++ E + +A++ V +PG F+ + + LR S+++ E + + L Sbjct: 329 MELPKG-LSAEGLFRRALEENVAFVPGGPFFANGGGEN-TLRLSYATLDREGIAEGVRRL 386 Query: 418 AQLIK 422 + +K Sbjct: 387 GRALK 391 >1GC4-A nrPDB Length = 385 Score = 290 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 88/426 (20%), Positives = 170/426 (39%), Gaps = 48/426 (11%) Query: 5 RFITAASAARNPSPI----RTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 R ++ A P + ++ +G +++L G P+ F T E + Sbjct: 2 RGLSRRVQAMKPDAVVAVNAKALELRRQGV-DLVALTAGEPD-----FDTPEHVKEAAR- 54 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 + + +Y+P AGIPEL L + K + P + VT G Q Sbjct: 55 ----RALAQGKTKYAPPAGIPELREALAE---KFRRENGLSVTPE----ETIVTVGGSQA 103 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L +F+ I++PGD V++ P + + + G ++ V + + P Sbjct: 104 LFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETLPE-----------EGFVP 152 Query: 181 EDAKNPQKNTPKFL-YTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN 239 + + + TP+ V + NNPTG E + + LA ++DF ++ D+ Y L + Sbjct: 153 DPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVSDEIYEHLLYE 212 Query: 240 KFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTF 298 + + +K + +G RIG+ GPK +I+ + + ST P T Sbjct: 213 GEHFSP--GRVAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMASVSRQSTTSPDTI 270 Query: 299 NQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWI 358 Q + L +E A V+ + Y ++D +L P+ ++ + Sbjct: 271 AQWATLEALTN--QEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVR---PSGAFYVLM 325 Query: 359 KVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLA 418 I + E+ ++ GV ++PG F A ++R S+++ S E + A + A Sbjct: 326 DTSPIAPDEVRAAERLLEAGVAVVPGTDF-----AAFGHVRLSYAT-SEENLRKALERFA 379 Query: 419 QLIKES 424 +++ + Sbjct: 380 RVLGRA 385 >1J32-A nrPDB Length = 388 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 91/426 (21%), Positives = 170/426 (39%), Gaps = 57/426 (13%) Query: 10 ASAARNPSPIRTMTDILSRGPK-------SMISLAGGLPNPNM--FPFKTAVITVENGKT 60 AAR S +MT I+ K + S + G P+ N + A +E GKT Sbjct: 2 KLAARVESVSPSMTLIIDAKAKAMKAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGKT 61 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 +Y P+AG P L + Q KL + Y G ++ VT+G +Q Sbjct: 62 ------------RYGPAAGEPRLREAIAQ---KLQRDNGLCY----GADNILVTNGGKQS 102 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 + + +I PGD V++ P + + + + + + + +++K Sbjct: 103 IFNLMLAMIEPGDEVIIPAPFWVSYPEMVKLAEGTPVILPT-----------TVETQFKV 151 Query: 181 EDAKNPQKNTPKFLYTVPN-GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN 239 + Q TPK V N +NPTG T + + I ++A + ++ D+ Y + ++ Sbjct: 152 SPEQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAIAQVAVEAGLWVLSDEIYEKILYD 211 Query: 240 KFRVPTF--LSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 + + S + R + F+K + +G R+GFL GP PL++ ST + Sbjct: 212 DAQHLSIGAASPEAYERSVVCSGFAKTYAMTGWRVGFLAGPVPLVKAATKIQGHSTSNVC 271 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFL 356 TF Q E V ++ ++ ++ +L A + + GL E P ++ Sbjct: 272 TFAQYGAIAAY-----ENSQDCVQEMLAAFAERRRYMLDALNA-MPGL-ECPKPDGAFYM 324 Query: 357 WIKV-KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQ 415 + + K + E + V +PG AF D +R S+++ + + + Sbjct: 325 FPSIAKTGRSSLDFCSELLDQHQVATVPGAAFGAD-----DCIRLSYAT-DLDTIKRGME 378 Query: 416 VLAQLI 421 L + + Sbjct: 379 RLEKFL 384 >4MY5-A nrPDB Length = 393 Score = 277 bits (707), Expect = 9e-75, Method: Composition-based stats. Identities = 88/428 (20%), Positives = 166/428 (38%), Gaps = 45/428 (10%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 M+ ++ S IR D ++ L G P+ F T E K Sbjct: 3 MDLSKRFNKNLNKIEVSMIRQ-FDQSISDIPDVLKLTLGEPD-----FATPKHIKEAAKR 56 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 +E Y+ AG+ L + + + Y P ++ VT G+ + Sbjct: 57 AIDADES-----HYTGMAGLLALRQAASAFVKEKY---HLTYNPDN---EILVTIGATEA 105 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS--DESGIVPDSLRDILSRW 178 L I+ PGD VLL PAY G ++ +G ++ + + ++ + P+ L + + + Sbjct: 106 LSASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEIDTRSNDFVLTPEMLEEAILK- 164 Query: 179 KPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQF 238 + E K N P NPTG + + ++ K + E+ +KY +I D+ Y L + Sbjct: 165 EGEALKAVILNYP---------TNPTGVTYSRQQIKNLAEVLKKYPIFVISDEVYAELTY 215 Query: 239 NKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPST 297 + D I SK + +G R+G + P L ++I Q +T Sbjct: 216 TGESHVSIAEYLPDQ-TILISGLSKSHAMTGWRLGLIFAPAVLTAQLIKSHQYLVTAATT 274 Query: 298 FNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLW 357 Q + L ++ + + Y ++D I+ + + P +++ Sbjct: 275 SVQFAAIEALTNGKDDALP-----MKEEYIKRRDYIIEKMEAMKFKII---KPDGAFYIF 326 Query: 358 IKVKG--INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQ 415 K+ D + +++ A + V +PG AF YLR S++ AS E + A + Sbjct: 327 AKIPVAQGQDSFKFLQDFAKEKAVAFIPGVAF---GKYGEGYLRISYA-ASMETIKEAMK 382 Query: 416 VLAQLIKE 423 L + +++ Sbjct: 383 RLKEFMEQ 390 >5WMH-A nrPDB Length = 475 Score = 276 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 93/438 (21%), Positives = 173/438 (39%), Gaps = 59/438 (13%) Query: 7 ITAASAARNPSPIRTMTDILSRGPK---SMISLAGGLPNPNMFPFKTAVITVENGKTIQF 63 ++ + PS +TD+ + + +I LA G P+ F T + E G I Sbjct: 72 LSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPD-----FDTPKVVAEAG--INA 124 Query: 64 GEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCK 123 E R Y+ +AGI EL + + KL + Y P Q + V++G++Q L + Sbjct: 125 IREGFTR---YTLNAGITELREAICR---KLKEENGLSYAPDQ----ILVSNGAKQSLLQ 174 Query: 124 VFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDA 183 + +PGD V++ P + + + + + S +D+ S+ + Sbjct: 175 AVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSR 234 Query: 184 KNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYD-FLIIEDDPYYFLQFNKFR 242 L + + +NPTG+ +EI + K+ L++ D+ Y + + Sbjct: 235 ----------LLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHIIYAPAT 284 Query: 243 VPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ 300 +F S+ D+ R + + FSK + +G R+G+L GPK ++ + S+ Q Sbjct: 285 HTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLAGPKHIVAACSKLQGQVSSGASSIAQ 344 Query: 301 LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV 360 L G V ++ Y ++D ++ + + P +L+I Sbjct: 345 KAGVAALGLGKAGG--ETVAEMVKAYRERRDFLVKSLGDIKG--VKISEPQGAFYLFIDF 400 Query: 361 KG-----------INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSS----- 404 IND L K V M+PG+AF DS +R S+++ Sbjct: 401 SAYYGSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDS-----CIRISYATSLDVL 455 Query: 405 -ASPEQMDVAFQVLAQLI 421 A+ E++ A + L + Sbjct: 456 QAAVEKIRKALEPLRATV 473 >6F77-B nrPDB Length = 400 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 84/436 (19%), Positives = 174/436 (39%), Gaps = 64/436 (14%) Query: 6 FITAASAARNPSPIRTMTDI---LSRGPKSMISLAGGLPNPNM--FPFKTAVITVENGKT 60 F+ A + PS ++ L + +I L G P+ + K A+ ++ G+T Sbjct: 3 FLADALSRVKPSATIAVSQKARELKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGET 62 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 +Y+P +GIPEL + + K + Y +Q V +G +Q Sbjct: 63 ------------KYTPVSGIPELREAIAK---KFKRENNLDYTAAQ----TIVGTGGKQI 103 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 L F +NPGD V++ P + + + G + V + + + +K Sbjct: 104 LFNAFMATLNPGDEVVIPAPYWVSYPEMVALCGGTPVFVPTRQE-----------NNFKL 152 Query: 181 EDAKNPQKNTPKFLYTVPN-GNNPTGNSLTSERKKEIYELARKYD-FLIIEDDPYYFLQF 238 + + TPK + V N +NP+G + + E K + ++ K+ ++ DD Y L + Sbjct: 153 KAEDLDRAITPKTKWFVFNSPSNPSGAAYSHEELKALTDVLMKHPHVWVLTDDMYEHLTY 212 Query: 239 NKFRVPTFLSMDV--DGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHP 295 FR T + ++ R + + SK + +G RIG+ GP LI+ + + T Sbjct: 213 GDFRFATPVEVEPGLYERTLTMNGVSKAYAMTGWRIGYAAGPLHLIKAMDMIQGQQTSGA 272 Query: 296 STFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMF 355 ++ Q + L G + R + + ++D +++ ++ P + Sbjct: 273 ASIAQWAAVEAL-----NGPQDFIGRNKEIFQGRRDLVVSMLNQ--AKGISCPTPEGAFY 325 Query: 356 LWIKVKGI-----------NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSS 404 ++ G+ ++ + E GV ++ G+AF + P R S+++ Sbjct: 326 VYPSCAGLIGKTAPSGKVIETDEDFVSELLETEGVAVVHGSAFGLG-----PNFRISYAT 380 Query: 405 ASPEQMDVAFQVLAQL 420 + ++ A + + + Sbjct: 381 SEA-LLEEACRRIQRF 395 >1O4S-A nrPDB Length = 389 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 81/420 (19%), Positives = 158/420 (37%), Gaps = 50/420 (11%) Query: 6 FITAASAARNPSPIRTMTDILSRGPK---SMISLAGGLPNPNMFPFKTAVITVENGKTIQ 62 ++ + S + K +I+L G P+ FP V+ + Sbjct: 13 MVSRRISEIPISKTMELDAKAKALIKKGEDVINLTAGEPD---FPTPEPVV-------EE 62 Query: 63 FGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLC 122 + K ++Y+ GI EL + + + + + VT+G++Q L Sbjct: 63 AVRFLQKGEVKYTDPRGIYELREGIAKRIGERYKK-------DISPDQVVVTNGAKQALF 115 Query: 123 KVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED 182 F +++PGD V++ P + + + G + V + S SL ++ + Sbjct: 116 NAFMALLDPGDEVIVFSPVWVSYIPQIILAGGTVNVVETFMSKNFQPSLEEVEGLLVGKT 175 Query: 183 AKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFR 242 + + NNPTG E + + LA+K +F II D+ Y L + Sbjct: 176 KA----------VLINSPNNPTGVVYRREFLEGLVRLAKKRNFYIISDEVYDSLVYTDEF 225 Query: 243 VPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 + R++ + FSK S +G R+G+L + + V +T +T Q Sbjct: 226 TSILDVSEGFDRIVYINGFSKSHSMTGWRVGYLISSEKVATAVSKIQSHTTSCINTVAQY 285 Query: 302 MISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK 361 + L ++ + +K+ ++ K E P +L+ KV+ Sbjct: 286 AALKALE--------VDNSYMVQTFKERKNFVVERLKKMGVKFVE---PEGAFYLFFKVR 334 Query: 362 GINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 G D + E + V ++PG+AF ++R SF++ S E++ A + + Sbjct: 335 G--DDVKFCERLLEEKKVALVPGSAFL-----KPGFVRLSFAT-SIERLTEALDRIEDFL 386 >6HNV-A nrPDB Length = 524 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 115/429 (26%), Positives = 199/429 (46%), Gaps = 57/429 (13%) Query: 43 PNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHY 102 P+ + + + T ++ R LQY+ G LL + + I+ H Sbjct: 100 PSSIHTPQSTVHISRHTTDPKLIDLA-RGLQYAAVEGHAPLLQFARDFIIRTHK------ 152 Query: 103 PPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV--- 159 P+ ++ +T+G+ GL K ++ ++ GD +L++E +S L+ G + V Sbjct: 153 -PNYDDWNVFITTGASDGLNKAADVFLDDGDVILVEEFTFSPFLRFSDNAGAKAVPVKIN 211 Query: 160 -ASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYE 218 +D GI D+L W+ P+ PK LYT+ G NPTG + + E +K+IY+ Sbjct: 212 FDNDSDGIDLTQFVDLLENWEKHYPNLPK---PKALYTIATGQNPTGFTQSLEFRKKIYD 268 Query: 219 LARKYDFLIIEDDPYYFLQFNKFR----------------------------VPTFLSMD 250 LA KYDF IIEDDPY +L K+ P++L +D Sbjct: 269 LAVKYDFAIIEDDPYGYLTLPKYEKPNIGGSGSGNNELKNDLEIDDYLKNHLTPSYLELD 328 Query: 251 VDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE- 309 GRV+R ++FSK+ + GLR+GF+ G K +I+ V + V S Q +++ ++ E Sbjct: 329 TTGRVLRVETFSKLFAPGLRLGFIVGHKEVIDAVKNYSDVVNRGASGLTQTIVNNVIQEN 388 Query: 310 -WGEEGFMAHVDRVIDFYSNQKDAILAAA---DKWLTGLAEWHVPAAGMFLWIKVKGIND 365 G +G++ + ++ YS +KD +L + + G + P AGMF+ K+ D Sbjct: 389 FKGVDGWLEWILKMRLNYSYRKDLLLYSIFESQAYKKGYVDVIDPKAGMFVTFKINLPKD 448 Query: 366 VK-----ELIEEKAVKMGVLMLPGNAFYVD---SSAPSPYLRASFSSA-SPEQMDVAFQV 416 V +L+ K + G+L++PG VD S S + R ++ A + E++ + + Sbjct: 449 VDVLQKMKLLLWKLISYGILVVPGYNMTVDLEFSKDRSNFFRLCYALANNDEEILESGKR 508 Query: 417 LAQLIKESL 425 L + E Sbjct: 509 LTDAVYEFF 517 >6F35-A nrPDB Length = 410 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 81/413 (19%), Positives = 166/413 (40%), Gaps = 61/413 (14%) Query: 26 LSRGPKSMISLAGGLPNPNM--FPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPEL 83 + R K +I L G P+ + + A + G+T +Y+ G PEL Sbjct: 36 MKREGKPVIILGAGEPDFDTPEHVKQAASDAIHRGET------------KYTALDGTPEL 83 Query: 84 LSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYS 143 +++ K + Y ++ V +G++Q L ++PGD V++ P ++ Sbjct: 84 KKAIRE---KFQRENGLAYELD----EITVATGAKQILFNAMMASLDPGDEVIIPTPYWT 136 Query: 144 GTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN-GNN 202 +H + +A D S S ++ K TP+ + + N +N Sbjct: 137 SYSDIVHICEGKPVLIACDAS-----------SGFRLTAEKLEAAITPRTRWVLLNSPSN 185 Query: 203 PTGNSLTSERKKEIYELARKYD-FLIIEDDPYYFLQFNKFRV--PTFLSMDVDGRVIRAD 259 P+G + ++ + + E+ ++ ++ DD Y + ++ FR P L + R + + Sbjct: 186 PSGAAYSAADYRPLLEVLLRHPHVWLLVDDMYEHIVYDGFRFVTPAQLEPGLKNRTLTVN 245 Query: 260 SFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAH 318 SK + +G RIG+ GP+ LI+ + + +T PS+ +Q L G Sbjct: 246 GVSKAYAMTGWRIGYAGGPRELIKAMAVVQSQATSCPSSISQAASVVAL-----NGPQDF 300 Query: 319 VDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKG-----------INDVK 367 + + + ++D ++ + + GL + VP + + G I Sbjct: 301 LKERTESFQRRRDLVVNGLNA-IDGL-DCRVPEGAFYTFSGCAGVLGKVTPSGKRIKTDT 358 Query: 368 ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 + V ++PG+AF + SP+ R S++++ E + A + +A Sbjct: 359 DFCAYLLEDAHVAVVPGSAFGL-----SPFFRISYATSEAE-LKEALERIAAA 405 >1U08-A nrPDB Length = 386 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 80/392 (20%), Positives = 150/392 (38%), Gaps = 43/392 (10%) Query: 34 ISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIK 93 I+L+ G P+ F E + + A QY+P G+ L + Q + Sbjct: 33 INLSQGFPD-----FDGPRYLQER-----LAHHVAQGANQYAPMTGVQALREAIAQKTER 82 Query: 94 LHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLG 153 L+ Y P D+ VT+G+ + L ++ GD V+ +P+Y ++ G Sbjct: 83 LYG-----YQPD-ADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSG 136 Query: 154 CNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERK 213 + +A D W+ E A + T + P +NP+ Sbjct: 137 GIVKRMALQPPHFRVD--------WQ-EFAALLSERTRLVILNTP--HNPSATVWQQADF 185 Query: 214 KEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFL-SMDVDGRVIRADSFSKIIS-SGLRI 271 +++ ++ +I D+ Y + F++ + L + R + SF K +G ++ Sbjct: 186 AALWQAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKV 245 Query: 272 GFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKD 331 G+ P P+ + Q T +T QL ++ +L E H + DFY ++D Sbjct: 246 GYCVAPAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPE-----HYLALPDFYRQKRD 300 Query: 332 AILAAADKWLTGLAEWHVPAAGMFLWIK---VKGINDVKELIEEKAVKMGVLMLPGNAFY 388 ++ A ++ + FL + V ++DV E + + GV +P + F Sbjct: 301 ILVNALNESRLEILPC---EGTYFLLVDYSAVSTLDDV-EFCQWLTQEHGVAAIPLSVFC 356 Query: 389 VDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 D P +R F+ + A + L QL Sbjct: 357 ADPF-PHKLIRLCFAKKESTLLAAA-ERLRQL 386 >2Z61-A nrPDB Length = 370 Score = 252 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 81/407 (19%), Positives = 152/407 (37%), Gaps = 55/407 (13%) Query: 19 IRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSA 78 I + L K +I L G P+ F T V+ G + + + Y+ S Sbjct: 17 ILALAQKLESEGKKVIHLEIGEPD-----FNTPKPIVDEG-----IKSLKEGKTHYTDSR 66 Query: 79 GIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLD 138 GI EL + +L + I ++ +T GS GL II+ GD VL+ Sbjct: 67 GILELREKISELYKDKYKADII-------PDNIIITGGSSLGLFFALSSIIDDGDEVLIQ 119 Query: 139 EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVP 198 P Y + LG + +SL + LS + Sbjct: 120 NPCYPCYKNFIRFLGAKPVFCD-----FTVESLEEALSDKTKA-------------IIIN 161 Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRA 258 + +NP G + E IYE A + II D+ Y L + + + I Sbjct: 162 SPSNPLGEVIDRE----IYEFAYENIPYIISDEIYNGLVYEGKCYSAIEFDENLEKTILI 217 Query: 259 DSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMA 317 + FSK+ + +G RIG++ +IE ++ Q + T +Q + + E Sbjct: 218 NGFSKLYAMTGWRIGYVISNDEIIEAILKLQQNLFISAPTISQYAALKAFEKETE----R 273 Query: 318 HVDRVIDFYSNQKDAILAAADKWLTGLA-EWHVPAAGMFLWIKVKGINDVKELIEEKAVK 376 ++ +I + ++ +L K++ E + P +++ + D +E + + Sbjct: 274 EINSMIKEFDRRRRLVL----KYVKDFGWEVNNPIGAYYVFPNI--GEDGREFAYKLLKE 327 Query: 377 MGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 V + PG F S Y+R S++++ E + + + + + + Sbjct: 328 KFVALTPGIGF---GSKGKNYIRISYANSY-ENIKEGLERIKEFLNK 370 >4WP0-A nrPDB Length = 472 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 73/412 (17%), Positives = 155/412 (37%), Gaps = 43/412 (10%) Query: 32 SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQ 91 +++L G P+ P AV ++ + F QY+ + G P L L Sbjct: 29 DVVNLGQGFPDFP--PPDFAVEAFQHAVSGDFM------LNQYTKTFGYPPLTKILASFF 80 Query: 92 IKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP 151 +L P + ++ VT G L F+ +++ GD V++ EP + Sbjct: 81 GEL---LGQEIDPLR---NVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMM 134 Query: 152 LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN-GNNPTGNSLTS 210 G + V+ + G + + S W+ + + K T + V N NNP G + Sbjct: 135 AGGRPVFVSL-KPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSR 193 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKII-SSG 268 E + + L +++D + I D+ Y ++ ++ + + S+ + R + S K ++G Sbjct: 194 EELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATG 253 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGE--EGFMAHVDRVIDFY 326 ++G++ GP +++ + Q S H T +Q +++ ++ + Sbjct: 254 WKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAM 313 Query: 327 SNQKDAILAAADKWLTGLAEWHVPAAGMFL----------WIKVKGIND---VKELIEEK 373 +D ++ + GL +P FL + G D + ++ Sbjct: 314 QRCRDHMIRSLQS--VGLKPI-IPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWM 370 Query: 374 AVKMGVLMLPGNAFYVDSSAPS--PYLRASFSSASPEQMDVAFQVLAQLIKE 423 G++ +P + FY Y+R F Q + + +++ Sbjct: 371 IKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEAT-----LQAMDEKLRK 417 >3FVS-A nrPDB Length = 422 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 73/412 (17%), Positives = 155/412 (37%), Gaps = 43/412 (10%) Query: 32 SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQ 91 +++L G P+ P AV ++ + F QY+ + G P L L Sbjct: 29 DVVNLGQGFPDFP--PPDFAVEAFQHAVSGDFM------LNQYTKTFGYPPLTKILASFF 80 Query: 92 IKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP 151 +L P + ++ VT G L F+ +++ GD V++ EP + Sbjct: 81 GEL---LGQEIDPLR---NVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMM 134 Query: 152 LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN-GNNPTGNSLTS 210 G + V+ + G + + S W+ + + K T + V N NNP G + Sbjct: 135 AGGRPVFVSL-KPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSR 193 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKII-SSG 268 E + + L +++D + I D+ Y ++ ++ + + S+ + R + S K ++G Sbjct: 194 EELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATG 253 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGE--EGFMAHVDRVIDFY 326 ++G++ GP +++ + Q S H T +Q +++ ++ + Sbjct: 254 WKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAM 313 Query: 327 SNQKDAILAAADKWLTGLAEWHVPAAGMFL----------WIKVKGIND---VKELIEEK 373 +D ++ + GL +P FL + G D + ++ Sbjct: 314 QRCRDHMIRSLQS--VGLKPI-IPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWM 370 Query: 374 AVKMGVLMLPGNAFYVDSSAPS--PYLRASFSSASPEQMDVAFQVLAQLIKE 423 G++ +P + FY Y+R F Q + + +++ Sbjct: 371 IKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEAT-----LQAMDEKLRK 417 >2ZJG-A nrPDB Length = 410 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 76/390 (19%), Positives = 146/390 (37%), Gaps = 38/390 (9%) Query: 31 KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQL 90 S+++L G P+ E F + M QY+ G P L+ L L Sbjct: 23 PSVVNLGQGFPD-----ISPPSYVKEELSKAAFIDNM----NQYTRGFGHPALVKALSCL 73 Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH 150 K++ P++ ++ V G+ L + +++PGD V++ P Y + Sbjct: 74 YGKIYQR---QIDPNE---EILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFYDCYEPMVR 127 Query: 151 PLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN-GNNPTGNSLT 209 G + + D ++ S W + + K + K + N +NP G T Sbjct: 128 MAGAVPVFIPLRSKPT--DGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYT 185 Query: 210 SERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-S 267 + + I +L K+D L I D+ Y +L + ++ + R I S K S + Sbjct: 186 RQELQVIADLCVKHDTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITIGSAGKTFSVT 245 Query: 268 GLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLH--EWGEEGFMAHVDRVIDF 325 G ++G+ GP LI+ + Q S +T Q +++ + + + + Sbjct: 246 GWKLGWSIGPAHLIKHLQTVQQNSFYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKE 305 Query: 326 YSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK----GINDV-------KELIEEKA 374 ++D ++ + GL VP G F+ V ++D+ + ++ Sbjct: 306 LEVKRDRMVRLLNS--VGLKPI-VPDGGYFIIADVSSLGADLSDMNSDEPYDYKFVKWMT 362 Query: 375 VKMGVLMLPGNAFYVDSSAPS--PYLRASF 402 + +P +AF S P +R F Sbjct: 363 KHKKLTAIPVSAFCDSKSKPHFEKLVRFCF 392 >1V2E-A nrPDB Length = 381 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 92/413 (22%), Positives = 159/413 (38%), Gaps = 51/413 (12%) Query: 10 ASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMK 69 + A S M+ + R ++L G P+ PF ++ + Sbjct: 6 RTEAAKESIFPRMSGLAQRL--GAVNLGQGFPSNPPPPF-----------LLEAVRRALG 52 Query: 70 RALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII 129 R QY+P AG+P L L + P + VTSG+ + L + + ++ Sbjct: 53 RQDQYAPPAGLPALREALAE---------EFAVEPE----SVVVTSGATEALYVLLQSLV 99 Query: 130 NPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKN 189 PGD V++ EP + L G V D + P+ R LS K Sbjct: 100 GPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLD---LTPEGFRLDLSAL----EKALTPR 152 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM 249 T L P NPTG + I LAR +D +I D+ Y L + P L Sbjct: 153 TRALLLNTP--MNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYY--GERPRRLRE 208 Query: 250 DVDGRVIRADSFSKII-SSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLH 308 R S K + ++G R+G++ GPK + R+ Q ++ T Q +++ L Sbjct: 209 FAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQWTSFSAPTPLQAGVAEALK 268 Query: 309 EWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKE 368 EGF + + + Y ++D + +VP FL ++ G + Sbjct: 269 LARREGF---YEALREGYRRRRDLLAGGLRAMG---LRVYVPEGTYFLMAELPGWD---- 318 Query: 369 LIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 + V ++P +AFY++ P R +F + E++ +A + L +++ Sbjct: 319 -AFRLVEEARVALIPASAFYLE-DPPKDLFRFAFCK-TEEELHLALERLGRVV 368 >5YHV-A nrPDB Length = 394 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 126/349 (36%), Gaps = 30/349 (8%) Query: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 L YS + GIPEL + + H I P + +T+GS G F + Sbjct: 68 LGYSVALGIPELRDAIAADYQRRH---GITVEPDA----VVITTGSSGGFLLAFLACFDA 120 Query: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 GD V + P Y L LGC ++ + +R++P + + P Sbjct: 121 GDRVAMASPGYPCYRNILSALGCEVVEIPCGPQ-----------TRFQPTAQMLAEIDPP 169 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV 251 V + NPTG + E I D +I D+ Y+ L + + Sbjct: 170 LRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCA-WQT 228 Query: 252 DGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 + +SFSK + +G R+G+L P L V T+ P +Q+ Sbjct: 229 SRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPE 288 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKG-INDVKEL 369 A D + Y+ + +L + G+ +++ V +D Sbjct: 289 A----TAEADGNLASYAINRSLLLDGLRRI--GIDRLAPTDGAFYVYADVSDFTSDSLAF 342 Query: 370 IEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLA 418 + GV + PG F D++ ++R SF+ S + ++ A + + Sbjct: 343 CSKLLADTGVAIAPGIDF--DTARGGSFVRISFAGPSGD-IEEALRRIG 388 >3H14-A nrPDB Length = 391 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 79/406 (19%), Positives = 149/406 (36%), Gaps = 46/406 (11%) Query: 19 IRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSA 78 + + +I + G P G + + AL Y+ + Sbjct: 19 VMEAARRAEEAGRRIIHMEVGQPG----------TGAPRGAVEALAKSLETDALGYTVAL 68 Query: 79 GIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLD 138 G+P L + +L + + + P + + +T GS G F + + GD V + Sbjct: 69 GLPALRQRIARLYGEWY---GVDLDPGR----VVITPGSSGGFLLAFTALFDSGDRVGIG 121 Query: 139 EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVP 198 P Y Q L LG +++ + +R +P A + + V Sbjct: 122 APGYPSYRQILRALGLVPVDLPTAPE-----------NRLQPVPADFAGLDLAGLM--VA 168 Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRA 258 + NPTG L + E A+ I D+ Y+ +++ + + T L + + VI Sbjct: 169 SPANPTGTMLDHAAMGALIEAAQAQGASFISDEIYHGIEY-EAKAVTALELTDECYVI-- 225 Query: 259 DSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMA 317 +SFSK S +G R+G++ P+ + V Q + +Q+ L E Sbjct: 226 NSFSKYFSMTGWRVGWMVVPEDQVRVVERIAQNMFICAPHASQVAALAALDCDAE----- 280 Query: 318 HVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI-NDVKELIEEKAVK 376 + +D Y + +L K G P +++ V + +D + E K Sbjct: 281 -LQANLDVYKANRKLMLERLPK--AGFTRIAPPDGAFYVYADVSDLTDDSRAFAAEILEK 337 Query: 377 MGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 GV + PG F D + LR S++ A+ + ++ L ++ Sbjct: 338 AGVAVTPGLDF--DPERGAGTLRFSYARATAD-IEEGLDRLEAFMQ 380 >1XI9-A nrPDB Length = 406 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 83/410 (20%), Positives = 164/410 (40%), Gaps = 48/410 (11%) Query: 26 LSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLS 85 L + +I L G +P F F+ E + + + + Y S G+PEL Sbjct: 33 LEKKGIKVIRLNIG--DPVKFDFQPPEHMKE-----AYCKAIKEGHNYYGDSEGLPELRK 85 Query: 86 WLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGT 145 + + + + + P D+ VT+ + L +F +++PGD +L+ P+Y Sbjct: 86 AIVEREKR---KNGVDITPD----DVRVTAAVTEALQLIFGALLDPGDEILVPGPSYPPY 138 Query: 146 LQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYT-VPNGNNPT 204 + G + + E W+P+ +K T + V N NNPT Sbjct: 139 TGLVKFYGGKPVEYRTIEE-----------EDWQPDIDDIRKKITDRTKAIAVINPNNPT 187 Query: 205 GNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKI 264 G + +EI +A +Y+ +I D+ Y + + + S+ D VI + SK+ Sbjct: 188 GALYDKKTLEEILNIAGEYEIPVISDEIYDLMTYEG-EHISPGSLTKDVPVIVMNGLSKV 246 Query: 265 I-SSGLRIGFL--TGPK----PLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMA 317 ++G R+G++ P+ + E + ++ L P+T Q L G M Sbjct: 247 YFATGWRLGYMYFVDPENKLSEVREAIDRLARIR-LCPNTPAQFAAIAGLT-----GPMD 300 Query: 318 HVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK--GINDVKELIEEKAV 375 ++ + ++D I ++ + G++ P +++ K++ + KE + + Sbjct: 301 YLKEYMKKLKERRDYIYKRLNE-IPGIST-TKPQGAFYIFPKIEVGPWKNDKEFVLDVLH 358 Query: 376 KMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL 425 VL + G+ F + + RA F E ++ A + +KE L Sbjct: 359 NAHVLFVHGSGF---GEYGAGHFRAVF-LPPIEILEEAMDRFEKFMKERL 404 >2O1B-A nrPDB Length = 404 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 91/428 (21%), Positives = 164/428 (38%), Gaps = 58/428 (13%) Query: 4 ARFITAASAARNPSPI-RTMTDILSRGPKSMISLAGGLPN-PN----MFPFKTAVITVEN 57 + I+ A S +TM + GP +I++A G+P+ P + F+ A+ EN Sbjct: 19 SHMISNKLANIPDSYFGKTMGRKIEHGPLPLINMAVGIPDGPTPQGIIDHFQKALTIPEN 78 Query: 58 GKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGS 117 K Y G + + +N + ++C+ G+ Sbjct: 79 QK--------------YGAFHGKEAFKQAIVDFYQRQYNVT------LDKEDEVCILYGT 118 Query: 118 QQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSR 177 + GL V +INPGD VLL +P Y+ L + + + + +PD Sbjct: 119 KNGLVAVPTCVINPGDYVLLPDPGYTDYLAGVLLADGKPVPLNLEPPHYLPD-------- 170 Query: 178 WKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQ 237 W D++ + K +Y NNPTG++ T E E + D I+ D Y Sbjct: 171 WSKVDSQ--IIDKTKLIYLT-YPNNPTGSTATKEVFDEAIAKFKGTDTKIVHDFAYGAFG 227 Query: 238 FNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 F+ S + I S SK + SG R+GF G K +I+ + + + Sbjct: 228 FDAKNPSILASENGKDVAIEIYSLSKGYNMSGFRVGFAVGNKDMIQALKKYQTHTN--AG 285 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVP----AA 352 F L ++ + ++ DF Q + D++ LA+ +P Sbjct: 286 MFGAL----------QDAAIYALNHYDDFLEEQSNVFKTRRDRFEAMLAKADLPFVHAKG 335 Query: 353 GMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDV 412 G+++W++ D ++ + + +L+ PG F + Y+R S + ++D Sbjct: 336 GIYVWLETPPGYDSEQFEQFLVQEKSILVAPGKPF---GENGNRYVRISLALDDQ-KLDE 391 Query: 413 AFQVLAQL 420 A L +L Sbjct: 392 AAIRLTEL 399 >2X5D-A nrPDB Length = 412 Score = 228 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 77/412 (18%), Positives = 151/412 (36%), Gaps = 42/412 (10%) Query: 16 PSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYS 75 + + R + +I L+ G P+ T VE T+ E YS Sbjct: 22 FNITAELKMAARRRGEDIIDLSMGNPD-----GPTPPHIVEKLCTVAQRE----DTHGYS 72 Query: 76 PSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNV 135 S GIP L + ++ + P + + VT GS++GL + ++ GD + Sbjct: 73 TSRGIPRLRRAISHWYRDRYD---VQIDP---ESEAIVTIGSKEGLAHLMLATLDHGDTI 126 Query: 136 LLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLY 195 L+ P+Y + G + +V GI + L R E P+ F Sbjct: 127 LVPNPSYPIHIYGAVIAGAQVRSVPL-VPGID---FFNELERAIRESIPKPRMMILGF-- 180 Query: 196 TVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLS-MDVDGR 254 +NPT + + + + LA++YD +++ D Y + ++ ++ P+ + Sbjct: 181 ----PSNPTAQCVELDFFERVVALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDI 236 Query: 255 VIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEE 313 + + SK + +G RIGF+ G L+ + T Q+ L E Sbjct: 237 AVEFFTLSKSYNMAGWRIGFMVGNPELVSALARIKSYHDYGTFTPLQVAAIAAL-----E 291 Query: 314 GFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGIND---VKELI 370 G V + Y ++D ++ + P A M++W K+ E Sbjct: 292 GDQQCVRDIARQYQQRRDVLVKGLREAGWM---VENPKASMYVWAKIPEPYAHLGSLEFA 348 Query: 371 EEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 ++ V + PG F ++R + + +++ A + + + + Sbjct: 349 KKLLQDAKVSVSPGIGF---GDYGDDHVRFAL-IENRDRLRQAVRGIKAMFR 396 >2GB3-A nrPDB Length = 409 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 88/428 (20%), Positives = 157/428 (36%), Gaps = 55/428 (12%) Query: 7 ITAASAARNPSPIRTMTDILSRGPKSMIS---LAGGLPNPNMFPFKTAVITVENGKTIQF 63 + SPIR + K + L G P+ P EN + + Sbjct: 16 FSDRVLLTEESPIRKLVPFAEMAKKRGVRIHHLNIGQPDLKT-PEVFFERIYENKPEVVY 74 Query: 64 GEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCK 123 YS SAGI EL + + P ++ VT+G + + Sbjct: 75 ----------YSHSAGIWELREAFASYYKRRQR---VDVKPE----NVLVTNGGSEAILF 117 Query: 124 VFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV--ASDESGIVPDSLRDILSRWKPE 181 F +I NPGD +L+ EP Y+ G +I V +E +P +L ++ Sbjct: 118 SFAVIANPGDEILVLEPFYANYNAFAKIAGVKLIPVTRRMEEGFAIPQNLESFINERTKG 177 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 + N NPTG + + + E+A ++ +I D+ Y + F + Sbjct: 178 -------------IVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYSEIVF-RG 223 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISS-GLRIGFLTG-PKPLIERVILHIQVSTLHPSTFN 299 + LS++ D +V+ DS SK S+ G R+G L + LI + Q L P Sbjct: 224 EFASALSIESD-KVVVIDSVSKKFSACGARVGCLITRNEELISHAMKLAQGR-LAPPLLE 281 Query: 300 QLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIK 359 Q+ LL+ + D V + Y + + +L ++ GL + P+ ++ + Sbjct: 282 QIGSVGLLNLDD-----SFFDFVRETYRERVETVLKKLEEH--GLKRFTKPSGAFYITAE 334 Query: 360 VKGINDVKELIEEKAVKMG-----VLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAF 414 + + D +E ++ P FY+ +R + + + A Sbjct: 335 LP-VEDAEEFARWMLTDFNMDGETTMVAPLRGFYLTPGLGKKEIRIA-CVLEKDLLSRAI 392 Query: 415 QVLAQLIK 422 VL + +K Sbjct: 393 DVLMEGLK 400 >3B46-A nrPDB Length = 447 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 73/384 (19%), Positives = 147/384 (38%), Gaps = 42/384 (10%) Query: 62 QFGEEMMKRAL------QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTS 115 QF + ++AL QYSP+ G P L++ L IKL++P Y ++ VT+ Sbjct: 73 QFAIKEAQKALDIPMVNQYSPTRGRPSLINSL----IKLYSPI---YNTELKAENVTVTT 125 Query: 116 GSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 G+ +G+ ++N GD V++ EP + + ++ G ++ V + + D Sbjct: 126 GANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL-DQRNTRG 184 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPN-GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 W + + + T K + N +NP G T E + + K++ +II D+ Y Sbjct: 185 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 244 Query: 235 FLQF-NKFRVPTFLSMDVDGRVIRADSFSKII-SSGLRIGFLTG-PKPLIERVILHIQVS 291 L F + F LS ++ + S K ++G RIG++ L+ Sbjct: 245 HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRI 304 Query: 292 TLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPA 351 + Q + +++ + G+ +++ Y N+ + D+ + P Sbjct: 305 CFASPSPLQEACANSINDALKIGYF---EKMRQEYINKFKIFTSIFDELG---LPYTAPE 358 Query: 352 AGMFLWIKVKGINDVKELIE---------------EKAVKMGVLMLPGNAFYV--DSSAP 394 F+ + + ++ ++GV+ +P FY+ A Sbjct: 359 GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAA 418 Query: 395 SPYLRASFSSASPEQMDVAFQVLA 418 LR + ++ A + L Sbjct: 419 ENLLRFAVCKDDA-YLENAVERLK 441 >3PDX-A nrPDB Length = 402 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 81/433 (18%), Positives = 157/433 (36%), Gaps = 66/433 (15%) Query: 14 RNPSPIRTMTDILSRGP---KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKR 70 + +PIR + D + P K++ISL+ G +P +F N T + MK Sbjct: 11 KTFNPIRAIVDNMKVKPNPNKTVISLSIG--DPTVF---------GNLPTDPEVTQAMKD 59 Query: 71 ALQ------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKV 124 AL Y+PS G LS +++ H P P + + D+ +TSG Q + Sbjct: 60 ALDSGKYNGYAPSIGY---LSSREEVASYYHCPEA----PLEAK-DVILTSGCSQAIELC 111 Query: 125 FEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAK 184 ++ NPG N+L+ P +S +G + W+ + + Sbjct: 112 LAVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPE-----------KSWEIDLKQ 160 Query: 185 NPQKNTPKF-LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRV 243 K V N +NP G+ + ++I +A + I+ D+ Y + F+ + Sbjct: 161 LESLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKY 220 Query: 244 PTFLSMDVDGRVIRADSFSK-IISSGLRIGFLTGPK-------PLIERVILHIQVSTLHP 295 ++ + ++ +K + G R+G++ + + ++ Q L P Sbjct: 221 EPMATLSTNVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQ-RILGP 279 Query: 296 STFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMF 355 T Q + +L +E + + F + D A + GL P+ M+ Sbjct: 280 CTIVQGALKSILQRTPQEFY----QDTLSFLKSNADLCYGALSA-IPGLQPVR-PSGAMY 333 Query: 356 LWIKVKGINDVK-----ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQM 410 L + ++ + + E E + V LP F + R + M Sbjct: 334 LMVGIEMEHFPEFENDVEFTERLIAEQSVHCLPATCFEY-----PNFFRVVITVPEV-MM 387 Query: 411 DVAFQVLAQLIKE 423 A + + ++ Sbjct: 388 LEACSRIQEFCEQ 400 >3DYD-A nrPDB Length = 427 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 82/435 (18%), Positives = 154/435 (35%), Gaps = 66/435 (15%) Query: 12 AARNPSPIRTMTDILSRGP---KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMM 68 A + +PIR + D + P K+MISL+ G +P +F N T + M Sbjct: 32 AKKTFNPIRAIVDNMKVKPNPNKTMISLSIG--DPTVF---------GNLPTDPEVTQAM 80 Query: 69 KRALQ------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLC 122 K AL Y+PS G + H P P + + D+ +TSG Q + Sbjct: 81 KDALDSGKYNGYAPSIGFLSSREEIA---SYYHCPEA----PLEAK-DVILTSGCSQAID 132 Query: 123 KVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED 182 ++ NPG N+L+ P +S +G + W+ + Sbjct: 133 LCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPE-----------KSWEIDL 181 Query: 183 AKNPQKNTPKF-LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 + K V N +NP G+ + ++I +A + I+ D+ Y + F+ Sbjct: 182 KQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDC 241 Query: 242 RVPTFLSMDVDGRVIRADSFSK-IISSGLRIGFLTGPK-------PLIERVILHIQVSTL 293 + ++ D ++ +K + G R+G++ + + ++ Q L Sbjct: 242 KYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQ-RIL 300 Query: 294 HPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAG 353 P T Q + +L E + + F + D A + GL P+ Sbjct: 301 GPCTIVQGALKSILCRTPGEFYHN----TLSFLKSNADLCYGAL-AAIPGLRPVR-PSGA 354 Query: 354 MFLWIKVKGINDVK-----ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPE 408 M+L + ++ + + E E + V LP F ++R + Sbjct: 355 MYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEY-----PNFIRVVITVPEV- 408 Query: 409 QMDVAFQVLAQLIKE 423 M A + + ++ Sbjct: 409 MMLEACSRIQEFCEQ 423 >3OP7-A nrPDB Length = 375 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 78/369 (21%), Positives = 143/369 (38%), Gaps = 46/369 (12%) Query: 59 KTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQ 118 F +++ L Y G P + QL P Q + T+G+ Sbjct: 44 NPEDFYKKLQGTKLNYGWIEGSPAFKKSVSQLYT--------GVKPEQ----ILQTNGAT 91 Query: 119 QGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRW 178 V +I PGD+V+ P Y LG + +E + W Sbjct: 92 GANLLVLYSLIEPGDHVISLYPTYQQLYDIPKSLGAEVDLWQIEEE-----------NGW 140 Query: 179 KPEDAKNPQKNTPKF-LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQ 237 P+ K Q P + + N NNPTG + +E+ E+A + I+ D+ Y Sbjct: 141 LPDLEKLRQLIRPTTKMICINNANNPTGAVMDRTYLEELVEIASEVGAYILSDEVYR--S 198 Query: 238 FNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 F++ VP+ + V + I +S SK S G+RIG++ + + + + + + Sbjct: 199 FSELDVPSIIE--VYDKGIAVNSLSKTYSLPGIRIGWVAANHQVTDILRDYRDYTMICAG 256 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTG--LAEWHVPAAGM 354 F+ L+ L H +++ + + LA D+W+ L + PA Sbjct: 257 VFDDLVAQLALA---------HYQEILERNRHILEENLAILDQWIEEEPLVSYIRPAVVS 307 Query: 355 FLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAF 414 ++K+ +++ + + GVL++PGN F D Y+R F+ E + Sbjct: 308 TSFVKIAVDMPMEDFCLQLLQEHGVLLVPGNRFERDG-----YVRLGFA-CEQETLIKGL 361 Query: 415 QVLAQLIKE 423 + L+Q ++ Sbjct: 362 EKLSQFLRR 370 >2O0R-A nrPDB Length = 411 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 81/401 (20%), Positives = 148/401 (36%), Gaps = 50/401 (12%) Query: 32 SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRAL-QYSPSAGIPELLSWLKQL 90 ++L G P+ + P K +Q ++ + + QY P G L + Sbjct: 26 GAVNLGQGFPDEDGPP-----------KMLQAAQDAIAGGVNQYPPGPGSAPLRRAIAAQ 74 Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH 150 + + + Y P + ++ VT G+ + + ++ PG VLL EP Y + Sbjct: 75 RRRHF---GVDYDP---ETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVA 128 Query: 151 PLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN-GNNPTGNSLT 209 G + + V G + + + TP+ + N +NPTG L+ Sbjct: 129 MAGAHRVTVPLVPDG----------RGFALDADALRRAVTPRTRALIINSPHNPTGAVLS 178 Query: 210 SERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMD-VDGRVIRADSFSKIIS-S 267 + I E+A + ++I D+ Y L F+ R D + R I S +K+ + + Sbjct: 179 ATELAAIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCT 238 Query: 268 GLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYS 327 G +IG+ GP LI V Q + Q ++ L A V + + Sbjct: 239 GWKIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTED-----AWVAALRNSLR 293 Query: 328 NQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK--GINDVKELIEEKAVKMGVLMLPGN 385 ++D + A + H FL + G +D E K+GV +P + Sbjct: 294 ARRDRLAAGLTEIGFA---VHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMS 350 Query: 386 AFYV--------DSSAPSPYLRASFSSASPEQMDVAFQVLA 418 AF + + +R +F + +D A + L+ Sbjct: 351 AFCDPAAGQASQQADVWNHLVRFTFCKRD-DTLDEAIRRLS 390 >1YIY-A nrPDB Length = 429 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 68/411 (16%), Positives = 150/411 (36%), Gaps = 47/411 (11%) Query: 34 ISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIK 93 ++L G P+ + + + A QY+ G P L+ L +L + Sbjct: 40 LNLGQGFPDYHAPKYALNALAAAANSPDPL-------ANQYTRGFGHPRLVQALSKLYSQ 92 Query: 94 LHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLG 153 L + ++ VT G+ + L + ++ GD V++ EP + + G Sbjct: 93 LVDRTI------NPMTEVLVTVGAYEALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAG 146 Query: 154 CNIINVASDESGIVPDSLRDILS--RWKPEDAKNPQKNTPKF-LYTVPNGNNPTGNSLTS 210 + + P+ +S W ++ + K + + +NP G + Sbjct: 147 GIPRFIP-----LKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGKVMDR 201 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-SG 268 + + L +K++ L + D+ Y + F F ++ + R I S K S +G Sbjct: 202 AELEVVANLCKKWNVLCVSDEVYEHMVFEPFEHIRICTLPGMWERTITIGSAGKTFSLTG 261 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEE--GFMAHVDRVIDFY 326 +IG+ GP+ L++ + + Q +T Q I+ + + + + Sbjct: 262 WKIGWAYGPEALLKNLQMVHQNCVYTCATPIQEAIAVGFETELKRLKSPECYFNSISGEL 321 Query: 327 SNQKDAILAAADKWLTGLAEWHVPAAGMFL---WIKVKGINDVKE---------LIEEKA 374 ++D + + + VP G F+ W + D+ + + Sbjct: 322 MAKRDYMASFLAEVGMN---PTVPQGGYFMVADWSSLDSKVDLTQETDARKDYRFTKWMT 378 Query: 375 VKMGVLMLPGNAFYVDSSA--PSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 +G+ +P +AFY + + ++R F + D Q A+++++ Sbjct: 379 KSVGLQGIPPSAFYSEPNKHLGEDFVRYCFF-----KKDENLQKAAEILRK 424 >4CVQ-A nrPDB Length = 431 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 77/421 (18%), Positives = 155/421 (36%), Gaps = 51/421 (12%) Query: 14 RNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQ 73 ++ + G K ++ L G P P F F + + + A Sbjct: 43 IRGPVLKEAKRLEEEGNK-VLKLNIGNPAP--FGFDAPD------EILVDVIRNLPTAQG 93 Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y S G+ + Q D+ + +G + + + + ++N GD Sbjct: 94 YCDSKGLYSARKAIMQHYQAR-------GMRDVTVEDIYIGNGVSELIVQAMQALLNSGD 146 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 +L+ P Y ++ + L D S W P+ K TP+ Sbjct: 147 EMLVPAPDYPLWTAAVSLSSGKAV-----------HYLCDESSDWFPDLDDIRAKITPRT 195 Query: 194 L-YTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD 252 + N NNPTG + E EI E+AR+++ +I D+ Y + ++ + + D Sbjct: 196 RGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPD 255 Query: 253 GRVIRADSFSKII-SSGLRIGFLT--GPKP----LIERVILHIQVSTLHPSTFNQLMISQ 305 I + SK +G R G++ GPK IE + + + L + Q I Sbjct: 256 LLTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMR-LCANVPAQHAIQT 314 Query: 306 LLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKG--- 362 L G + + Y Q++ + + G P ++++ K+ Sbjct: 315 ALG--GYQSISEFITPGGRLY-EQRNRAWELIND-IPG-VSCVKPRGALYMFPKIDAKRF 369 Query: 363 -INDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP-YLRASFSSASPEQMDVAFQVLAQL 420 I+D ++++ + ++ VL++ G AF + P P + R + + ++++ A+ Sbjct: 370 NIHDDQKMVLDFLLQEKVLLVQGTAF----NWPWPDHFRI-VTLPRVDDIELSLSKFARF 424 Query: 421 I 421 + Sbjct: 425 L 425 >3G7Q-A nrPDB Length = 417 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 80/412 (19%), Positives = 148/412 (35%), Gaps = 45/412 (10%) Query: 30 PKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRAL-QYSPSAGIPELLSWLK 88 I L GG P + T AL Y G Sbjct: 30 TPGAIMLGGGNPA----HIPAMQDYFQTLLTDMVESGKAADALCNYDGPQGKTA------ 79 Query: 89 QLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN---PGD--NVLLD-EPAY 142 L L ++ +T+GSQ +F + G VL P Y Sbjct: 80 -LLNALAVLLRETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEY 138 Query: 143 SGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNN 202 G S L ++ A ++P+ + ++ + V N Sbjct: 139 IGYADS--GLEDDLFVSARPNIELLPEGQFKYHVDF-----EHLHIGEETGMICVSRPTN 191 Query: 203 PTGNSLTSERKKEIYELARKYDFLIIEDDPYY----FLQFNKFRVPTFLSMDVDGRVIRA 258 PTGN +T E ++ LA +++ ++ D+ Y + F++ R + +I Sbjct: 192 PTGNVITDEELMKLDRLANQHNIPLVIDNAYGVPFPGIIFSEARPL------WNPNIILC 245 Query: 259 DSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAH 318 S SK+ G R G + I + + +L P M+ +++ + Sbjct: 246 MSLSKLGLPGSRCGIIIANDKTITAIANMNGIISLAPGGMGPAMMCEMIKR---NDLLRL 302 Query: 319 VDRVID-FYSNQKDAILAAADKWLTGL-AEWHVPAAGMFLWIKVKGINDVKELIEEKAVK 376 + VI FY + +A ++L+ H P +FLW+ K + EL+ ++ Sbjct: 303 SETVIKPFYYQRVQQTIAIIRRYLSEERCLIHKPEGAIFLWLWFKDLPITTELLYQRLKA 362 Query: 377 MGVLMLPGNAFYVDSSAPSPY----LRASFSSASPEQMDVAFQVLAQLIKES 424 GVLM+PG+ F+ P P+ +R ++ P++++ ++LA+ I+ + Sbjct: 363 RGVLMVPGHYFFPGLDKPWPHTHQCMRMNYV-PEPDKIEAGVKILAEEIERA 413 >3JTX-A nrPDB Length = 396 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 77/398 (19%), Positives = 147/398 (36%), Gaps = 45/398 (11%) Query: 39 GLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQ----YSPSAGIPELLSWLKQLQIKL 94 G+ P I T + + + +L Y +AG+PEL + Sbjct: 23 GISAPEGMEAVPLHIGEPKHPTPKVITDALTASLHELEKYPLTAGLPELRQACANWLKRR 82 Query: 95 HNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDN-----VLLDEPAYSGTLQSL 149 ++ T+ ++ GS++ L + ++NP + ++ P Y + Sbjct: 83 YDGLTVD-----ADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIVSPNPFYQIYEGAT 137 Query: 150 HPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLT 209 G I PD WK L V + NNP+G+ L Sbjct: 138 LLGGGEIHFANCPAPSFNPDWRSISEEVWKRTK-----------LVFVCSPNNPSGSVLD 186 Query: 210 SERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD-----GRVIRADSFSKI 264 + KE+++L KY F+I D+ Y + F+ + L +++ S SK Sbjct: 187 LDGWKEVFDLQDKYGFIIASDECYSEIYFDGNKPLGCLQAAAQLGRSRQKLLMFTSLSKR 246 Query: 265 IS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVI 323 + GLR GF+ G L++ +L T H S + + + W +E HV Sbjct: 247 SNVPGLRSGFVAGDAELLKNFLL---YRTYHGSAMSIPVQRASIAAWDDE---QHVIDNR 300 Query: 324 DFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLP 383 Y + + ++ + + + +P A ++W+KV +D+ K + +LP Sbjct: 301 RLYQEKFERVIPILQQ----VFDVKLPDASFYIWLKVPDGDDLA-FARNLWQKAAIQVLP 355 Query: 384 GNAFYVDSSAPSP---YLRASFSSASPEQMDVAFQVLA 418 G D+ +P Y+R + + + A +++ Sbjct: 356 GRFLARDTEQGNPGEGYVRIALVADVATCVKAAEDIVS 393 >3IF2-A nrPDB Length = 444 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 86/451 (19%), Positives = 156/451 (34%), Gaps = 41/451 (9%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNP----NMFPFKTAVITVE 56 M +++F + S + + + + L GG P N +T Sbjct: 2 MKFSKFGQKFTQPTGISQLMDDLGDALKSDQPVNMLGGGNPAKIDAVNELFLETYKALGN 61 Query: 57 NGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 + T + + YS G + L + ++ ++ +T+G Sbjct: 62 DNDTGKANSSAIISMANYSNPQGDSAFIDALVGFFNRHYDWN-------LTSENIALTNG 114 Query: 117 SQQGLCKVFE----MIINPGDN----------VLLD-EPAYSGTLQSLHPLGCNIINVAS 161 SQ +F +N +LL P Y G +H G + V Sbjct: 115 SQNAFFYLFNLFGGAFVNEHSQDKESKSVDKSILLPLTPEYIGYSD-VHVEGQHFAAVLP 173 Query: 162 DESGIVPDSLRDILS-RWKPEDAKNPQKNTPKFLYTVP--NGNNPTGNSLTSERKKEIYE 218 + D R E +N + + NPTGN LT E + E Sbjct: 174 HIDEVTHDGEEGFFKYRVDFEALENLPALKEGRIGAICCSRPTNPTGNVLTDEEMAHLAE 233 Query: 219 LARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPK 278 +A++YD +I D+ Y + F + + ++ D I S SKI G+R G + Sbjct: 234 IAKRYDIPLIIDNAYG-MPF-PNIIYSDAHLNWDNNTILCFSLSKIGLPGMRTGIIVADA 291 Query: 279 PLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAAD 338 +IE V V L P+ F + + L+ + + + FY Q + Sbjct: 292 KVIEAVSAMNAVVNLAPTRFGAAIATPLVANDRIKQLSD--NEIKPFYQKQATLAVKLLK 349 Query: 339 KWLTGLAE-WHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYV-----DSS 392 + L H P +FLW+ K + + E+ G L++P F+ D Sbjct: 350 QALGDYPLMIHKPEGAIFLWLWFKDLPISTLDLYERLKAKGTLIVPSEYFFPGVDVSDYQ 409 Query: 393 APSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 +R S ++ +D +V+ ++++E Sbjct: 410 HAHECIRMSIAADEQTLID-GIKVIGEVVRE 439 >5IWQ-A nrPDB Length = 434 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 116/297 (39%), Gaps = 27/297 (9%) Query: 136 LLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLY 195 + P Y G +I+V +E G D++ +++ K ++ Sbjct: 136 ICPVPGYDRHFSITERFGFEMISVPMNEDGPDMDAVEELVKN-----------PQVKGMW 184 Query: 196 TVPNGNNPTGNSLTSERKKEIYEL-ARKYDFLIIEDDPYYFLQFNKFRVPTFLSM----- 249 VP +NPTG ++T + K + + DF ++ D+ Y P + + Sbjct: 185 VVPVFSNPTGFTVTEDVAKRLSAMETAAPDFRVVWDNAYAVHTLTD-EFPEVIDIVGLGE 243 Query: 250 --DVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLL 307 R S SKI +G + F + H + + P+ NQL ++ Sbjct: 244 AAGNPNRFWAFTSTSKITLAGAGVSFFLTSAENRKWYTGHAGIRGIGPNKVNQLAHARYF 303 Query: 308 HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT--GLAEWHVPAAGMFLWIKVKGIND 365 + EG A + + + + + +L D L G+A+W VPA G F+ + V Sbjct: 304 GDA--EGVRAVMRKHAASLAPKFNKVLEILDSRLAEYGVAQWTVPAGGYFISLDVVPG-- 359 Query: 366 VKELIEEKAVKMGVLML-PGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 + E A + G+ + G+++ + + LR + S E+++VA +A + Sbjct: 360 TASRVAELAKEAGIALTGAGSSYPLRQDPENKNLRLAPSLPPVEELEVAMDGVATCV 416 >3NRA-A nrPDB Length = 407 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 130/354 (36%), Gaps = 27/354 (7%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y+ G + L P + L +T G+Q L + GD Sbjct: 74 YTEYRGDLGIRDLLAPRLAAFTG------APVDARDGLIITPGTQGALFLAVAATVARGD 127 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 V + +P Y + + ++ V D + D R L E+A Sbjct: 128 KVAIVQPDYFANRKLVEFFEGEMVPVQLDY--VSADETRAGLDLTGLEEAFKAGAR---- 181 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF--RVPTFLSMDV 251 ++ N NNP G ++E +I LA +Y +I D Y L++ + Sbjct: 182 VFLFSNPNNPAGVVYSAEEIGQIAALAARYGATVIADQLYSRLRYAGASYTHLRAEAAVD 241 Query: 252 DGRVIRADSFSKI-ISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 V+ SK SG R+G G + +I R+ + +L + ++Q +L W Sbjct: 242 AENVVTIMGPSKTESLSGYRLGVAFGSRAIIARMEKLQAIVSLRAAGYSQ----AVLRGW 297 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDV-KEL 369 +E ++ I + +D +L A P AG +L+ ++ + E Sbjct: 298 FDEA-PGWMEDRIARHQAIRDELLHVLRGCEGVFAR--TPQAGSYLFPRLPKLAVAPAEF 354 Query: 370 IEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 ++ ++ GV++ PG F ++ +R +FS E A + + L++ Sbjct: 355 VKILRLQAGVVVTPGTEFSPHTADS---VRLNFSQ-DHEAAVAAARRIVTLVER 404 >3EZ1-A nrPDB Length = 423 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 75/360 (20%), Positives = 134/360 (37%), Gaps = 31/360 (8%) Query: 78 AGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP----GD 133 AG+P L + + + + S ++ V L P Sbjct: 70 AGLPSAR-ALFAGYLDVKAENVLVWNNSSLELQGLVL---TFALLHGVRGSTGPWLSQTP 125 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 +++ P Y L LG ++ V G D++ + + K Sbjct: 126 KMIVTVPGYDRHFLLLQTLGFELLTVDMQSDGPDVDAVERL----------AGTDPSVKG 175 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYEL-ARKYDFLIIEDDPY---YFLQFNKFRVPTFLSM 249 + VP +NP G +++ E+ + + L A DF I DD Y + ++ ++ F+ + Sbjct: 176 ILFVPTYSNPGGETISLEKARRLAGLQAAAPDFTIFADDAYRVHHLVEEDRAEPVNFVVL 235 Query: 250 DVD----GRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQ 305 D R S SKI +G +GF+ + I + ++ ++ P+ Q + Sbjct: 236 ARDAGYPDRAFVFASTSKITFAGAGLGFVASSEDNIRWLSKYLGAQSIGPNKVEQARHVK 295 Query: 306 LLHEW--GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI 363 L E+ G EG M +I D +L A A W +P G F+ + Sbjct: 296 FLTEYPGGLEGLMRDHAAIIAPKFRAVDEVLRAELGEGGEYATWTLPKGGYFISLDTA-- 353 Query: 364 NDVKELIEEKAVKMGVLMLPGNAFYVDSSAP-SPYLRASFSSASPEQMDVAFQVLAQLIK 422 V + + + A GV + P A Y P + LR + + E++ A QV+A I+ Sbjct: 354 EPVADRVVKLAEAAGVSLTPAGATYPAGQDPHNRNLRLAPTRPPVEEVRTAMQVVAACIR 413 >4M2J-A nrPDB Length = 406 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 69/364 (18%), Positives = 123/364 (33%), Gaps = 58/364 (15%) Query: 75 SPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDN 134 S S G + + + VT GS + + +++ GD Sbjct: 81 SVSQGGEGVRRAIADRYA------------GGDADRVLVTHGSSEAIALTLNALLHRGDR 128 Query: 135 VLLDEPAYSGTLQSLHPLGCNIINVA---SDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 V++ E Y GC++ + + I PD L ++ TP Sbjct: 129 VVVQEGIYHSLGHYPRAAGCDVAVLPGRAVRDGEIDPDVLAGLV--------------TP 174 Query: 192 KFLYTVPN-GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMD 250 + N +NPTG +L+ + + + E +++ D + +++ V D Sbjct: 175 GTAAVIVNFPHNPTGVTLSPQGLRALKERTAATGAVLVWDAATAEIA-HRWEVLADPGAD 233 Query: 251 VDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE 309 G + + SK GLR+G+ PK L+ +TL S +L+ + + Sbjct: 234 G-GDTVSYGTLSKTFGLPGLRVGWAVAPKELLTATFPLRDRTTLFLSPLVELVAERAVR- 291 Query: 310 WGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT---GLAEWHVPAAGMF-------LWIK 359 H D +I + + LA W+ L W P G+ L Sbjct: 292 --------HADELIGARAAEARHNLAHLTGWMAAHEELVRWTPPEGGVCALPVFRELERA 343 Query: 360 VKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQ 419 G +V+ E + L++PG AF A R F E L++ Sbjct: 344 AAGPQEVERFCLELLERHRTLLVPGTAFGAPHGA-----RLGFG-GPQEDFRAGLDGLSR 397 Query: 420 LIKE 423 ++E Sbjct: 398 FLRE 401 >1BW0-A nrPDB Length = 416 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 77/432 (17%), Positives = 151/432 (34%), Gaps = 51/432 (11%) Query: 12 AARNPSPIRTMTDILSRGP--KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMK 69 A +PIRT++D P K +I L+ G P + +A + + I + Sbjct: 12 AGLVFNPIRTVSDNAKPSPSPKPIIKLSVGDPTLDKNLLTSAAQIKKLKEAID-----SQ 66 Query: 70 RALQYSPSAGIPELLSWLKQL--QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEM 127 Y P+ G PE + +H + + ++ + SG G+ Sbjct: 67 ECNGYFPTVGSPEAREAVATWWRNSFVHKE---ELKSTIVKDNVVLCSGGSHGILMAITA 123 Query: 128 IINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQ 187 I + GD L+ +P + G + + W+ + + + Sbjct: 124 ICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPE-----------NDWEADLDEIRR 172 Query: 188 KNTPKF-LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTF 246 K L V N +NP G++ + + ++I LA + + D+ Y + F Sbjct: 173 LKDDKTKLLIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMVFKGKDPNAT 232 Query: 247 LSMDVD-----GRVIRADSFSKIISSGLRIGFLT-----GPKPLIERVILHIQVSTLHPS 296 + D RVI + ++ G R+G+L G P + + + P Sbjct: 233 FTSVADFETTVPRVILGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPC 292 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFL 356 T Q + + L +E H+D+++ + + + GLA +P M+L Sbjct: 293 TVVQAALGEALLNTPQE----HLDQIVAKIEESAMYLYNHIGECI-GLAP-TMPRGAMYL 346 Query: 357 WIKV-----KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMD 411 ++ + I E E+ + V +LPG F + R + ++ E Sbjct: 347 MSRIDLEKYRDIKTDVEFFEKLLEEENVQVLPGTIF-----HAPGFTRLT-TTRPVEVYR 400 Query: 412 VAFQVLAQLIKE 423 A + + + Sbjct: 401 EAVERIKAFCQR 412 >5X03-B nrPDB Length = 365 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 69/395 (17%), Positives = 138/395 (34%), Gaps = 37/395 (9%) Query: 32 SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQ 91 IS + + + FP K+ + + S GI E+ + + +L Sbjct: 1 DWISFSHMSSDTDHFPIKSWFRCEQKA-----ASRSYRTLGDMSHPQGIYEVRAAITRLI 55 Query: 92 IKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP 151 + P Q + + +G Q L ++ ++ ++EP Y Q L Sbjct: 56 SLT---RGVKCRPEQ----MIIGAG-TQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKN 107 Query: 152 LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE 211 G + + DE G+ + P L T P+ P+G + Sbjct: 108 AGKQVKTIMLDEKGM---------------SIAEITRQQPDVLVTTPSHQFPSGTIMPVS 152 Query: 212 RKKEIYELARK-YDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLR 270 R+ ++ A + IIEDD ++ +P S+D VI +FSK + GLR Sbjct: 153 RRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLR 212 Query: 271 IGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 I ++ P L+ S+ QL + + + + H+ ++ Y ++ Sbjct: 213 ISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESG---EYQKHIKKMKQHYKEKR 268 Query: 331 DAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYV- 389 + ++ A + +G AG+ ++ ++ I A + + + + F + Sbjct: 269 ERLITALEAEFSGEVTVKGANAGLH-FVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLK 327 Query: 390 --DSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 P L F+ E + Q L + + Sbjct: 328 ENKRQTGRPALIIGFARLKEEDIQEGVQRLFKAVY 362 >4N0B-A nrPDB Length = 479 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 70/411 (17%), Positives = 141/411 (34%), Gaps = 37/411 (9%) Query: 16 PSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYS 75 P + + IS + + + FP K+ + + S Sbjct: 92 PFALPDDLKEIHIDQSDWISFSHMSSDTDHFPIKSWFRCEQKA-----ASRSYRTLGDMS 146 Query: 76 PSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNV 135 GI E+ + + +L + P Q + + +G Q L ++ ++ Sbjct: 147 HPQGIYEVRAAITRLISLT---RGVKCRPEQ----MIIGAG-TQVLMQLLTELLPKEAVY 198 Query: 136 LLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLY 195 ++EP Y Q L G + + DE G+ + P L Sbjct: 199 AMEEPGYRRMYQLLKNAGKQVKTIMLDEKGM---------------SIAEITRQQPDVLV 243 Query: 196 TVPNGNNPTGNSLTSERKKEIYELARK-YDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGR 254 T P+ P+G + R+ ++ A + IIEDD ++ +P S+D Sbjct: 244 TTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSLDRFQN 303 Query: 255 VIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG 314 VI +FSK + GLRI ++ P L+ S+ QL + + + Sbjct: 304 VIYMGTFSKSLLPGLRISYMVLPPELLRAY-KQRGYDLQTCSSLTQLTLQEFIESG---E 359 Query: 315 FMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKA 374 + H+ ++ Y +++ ++ A + +G AG+ ++ ++ I A Sbjct: 360 YQKHIKKMKQHYKEKRERLITALEAEFSGEVTVKGANAGLH-FVTEFDTRRTEQDILSHA 418 Query: 375 VKMGVLMLPGNAFYV---DSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 + + + + F + P L F+ E + Q L + + Sbjct: 419 AGLQLEIFGMSRFNLKENKRQTGRPALIIGFARLKEEDIQEGVQRLFKAVY 469 >2DOU-A nrPDB Length = 376 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 72/405 (17%), Positives = 132/405 (32%), Gaps = 35/405 (8%) Query: 18 PIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPS 77 P ++ ++ + GL + ++ + + Y Sbjct: 5 PEPSVFLVVDEAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTY--GYCLK 62 Query: 78 AGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLL 137 + L + + + P + + GSQ+GL + + P D +LL Sbjct: 63 SCTLPFLEEAARWYEGRY---GVGLDP---RREALALIGSQEGLAHLLLALTEPEDLLLL 116 Query: 138 DEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTV 197 E AY + + E G+ + PE K + + Sbjct: 117 PEVAYPSYFGAARVASLRTFLIPLREDGL-------ADLKAVPEGVWREAK-----VLLL 164 Query: 198 PNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIR 257 NNPTG +E LARK+ +I D+PY + RV+ Sbjct: 165 NYPNNPTGAVADWGYFEEALGLARKHGLWLIHDNPYVDQVYEGEAPSPLALPGAKERVVE 224 Query: 258 ADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFM 316 S SK + +G R+GF G + + R+ V FNQ + G E Sbjct: 225 LFSLSKSYNLAGFRLGFALGSEEALARLERVKGVID-----FNQYAG---VLRMGVEALK 276 Query: 317 AHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVK 376 + V + ++ L A+ L G+ P A M+LW ++ D E + V+ Sbjct: 277 TPKEVVRGYARVYRERALGMAEA-LKGVLSLLPPRATMYLWGRLPEGVDDLEFGL-RLVE 334 Query: 377 MGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 GV + ++R + E++ A + + + + Sbjct: 335 RGVALA---PGRGFGPGGKGFVRIALVR-PLEELLEAAKRIREAL 375 >4IX8-A nrPDB Length = 444 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 72/435 (16%), Positives = 153/435 (35%), Gaps = 44/435 (10%) Query: 3 YARFITAASAARNPSPIRTMTDILS--RGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 + R ++ A R P+ +TD + R KS + L+ G +P + V Sbjct: 37 FRRIASSKHAQRTLQPLNNLTDNMKPSRSTKSNLRLSIG--DPTVDGNLKTPDIVTEAMV 94 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 Y P+ G L + + T + ++ +TSG Q Sbjct: 95 DVVRSGKFNG---YPPTVGADNLRQVVSTYWRRF--CQTKSRQEALKWENVIITSGVSQA 149 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 + + N GDN+L+ P++ G + + P W+ Sbjct: 150 IVLALTALCNEGDNILVCAPSFPHYKSVCDSYG-----IECRYYYLDP------SKSWEC 198 Query: 181 EDAKNPQKNTPKFL-YTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN 239 + + + N +NP G++ + +I + +++ +I D+ Y + N Sbjct: 199 DLRAAAGMVDSHTKAFVIINPSNPCGSNFSRAHVSDIIDFCQQHQIPLISDEIYAEMVLN 258 Query: 240 KFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGF-LTGPKPLIE--RVILHIQVSTL-- 293 + D + + +K G R+G+ + + + +++ L Sbjct: 259 NGIFTSVADFDTNVPRLILGGTAKYQVCPGWRVGWSILIDPMNVAGDWAVGMERLTQLIA 318 Query: 294 HPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAG 353 ++ Q I++ L + E H+ ++ + + A + G+ P A Sbjct: 319 GVNSICQEAIARTLLKCPTE-CTEHIVTQLEAGAK----VYARLLEHDIGI-SMEAPQAS 372 Query: 354 MFLWIKV-----KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPE 408 MF+ +K+ + + E E+ + V +LPG F + S +LRA+ S S Sbjct: 373 MFVMLKLNLSYFQDLKSDMEFYEKLLDEENVQVLPGEIFGM-----SGFLRATVSRPSA- 426 Query: 409 QMDVAFQVLAQLIKE 423 ++ A + + + Sbjct: 427 VLNEAVDRIIEFCER 441 >3ELE-A nrPDB Length = 398 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 73/428 (17%), Positives = 147/428 (34%), Gaps = 69/428 (16%) Query: 17 SPIRTMTDILSR-----GPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRA 71 S IR + + + G +++ + G P + N + + A Sbjct: 16 SAIRELFEYGKKRAAIVGKENVYDFSIGNP-------SIPAPQIVNDTIKELVTDYDSVA 68 Query: 72 LQ-YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII- 129 L Y+ + G E + + + H +L +T G+ L F + Sbjct: 69 LHGYTSAQGDVETRAAIAEFLNNTHGTH-------FNADNLYMTMGAAASLSICFRALTS 121 Query: 130 NPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKN 189 + D + P + ++ G ++ V +D D DA + N Sbjct: 122 DAYDEFITIAPYFPEYKVFVNAAGARLVEVPADTEHFQIDF-----------DALEERIN 170 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARK------YDFLIIEDDPYYFLQFNKFRV 243 + + NNP+G + E K++ +L K II D+PY + ++ +V Sbjct: 171 AHTRGVIINSPNNPSGTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEPYREIVYDGIKV 230 Query: 244 PTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVST-------LHP 295 P + S+SK +S G RIG++ P + ++ L+ V + Sbjct: 231 PFVTKY--YDNTLVCYSYSKSLSLPGERIGYVLVPDEVYDKAELYAAVCGAGRALGYVCA 288 Query: 296 STFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMF 355 + Q MI + G+ I+ Y +D + + P + Sbjct: 289 PSLFQKMIVKCQGATGD----------INAYKENRDLLYEGLTRIG---YHCFKPDGAFY 335 Query: 356 LWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQ 415 +++K +D EKA + VL++ + F ++R S+ E + + Sbjct: 336 MFVK-ALEDDSNAFC-EKAKEEDVLIVAADGFGC-----PGWVRISYC-VDREMIKHSMP 387 Query: 416 VLAQLIKE 423 ++ K+ Sbjct: 388 AFEKIYKK 395 >1IAY-A nrPDB Length = 428 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 60/412 (14%), Positives = 140/412 (33%), Gaps = 38/412 (9%) Query: 28 RGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWL 87 + P +I + + + + G G + K + G+PE + Sbjct: 33 KNPNGVIQMGLAENQLCLDLIEDWIKRNPKGSICSEGIKSFKAIANFQDYHGLPEFRKAI 92 Query: 88 KQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQ 147 + K + + P + + + G+ + + +PGD L+ P Y + Sbjct: 93 AKFMEKTRG-GRVRFDPER----VVMAGGATGANETIIFCLADPGDAFLVPSPYYPAFNR 147 Query: 148 SLH-PLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFL-YTVPNGNNPTG 205 L G +I + + S I S+ E +N QK+ K + N +NP G Sbjct: 148 DLRWRTGVQLIPIHCESSNNF-----KITSKAVKEAYENAQKSNIKVKGLILTNPSNPLG 202 Query: 206 NSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD------ 259 +L + K + +++ ++ D+ Y F+ + + + + + + Sbjct: 203 TTLDKDTLKSVLSFTNQHNIHLVCDEIYAATVFDTPQFVSIAEILDEQEMTYCNKDLVHI 262 Query: 260 --SFSK-IISSGLRIGFLTG-PKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGF 315 S SK + G R+G + ++ + ST Q ++ +L + Sbjct: 263 VYSLSKDMGLPGFRVGIIYSFNDDVVNCARKMSSFGLV--STQTQYFLAAMLSDEKFVDN 320 Query: 316 MAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI----NDVKELIE 371 + ++ + + AG+F W+ ++ + E+ Sbjct: 321 FLRESAMRLGKRHK-----HFTNGLEVVGIKCLKNNAGLFCWMDLRPLLRESTFDSEMSL 375 Query: 372 EKAVKMGVL--MLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 + + V + PG++F + R F++ +D+A + + + Sbjct: 376 WRVIINDVKLNVSPGSSF---ECQEPGWFRVCFANMDDGTVDIALARIRRFV 424 >3ASB-A nrPDB Length = 400 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 73/405 (18%), Positives = 137/405 (33%), Gaps = 59/405 (14%) Query: 26 LSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLS 85 L ++I+L+ G P +V + R Y P G+P L Sbjct: 28 LENPQHTVINLSIGD---TTQPLNASVAEAFASSIARLSSPTTCRG--YGPDFGLPALRQ 82 Query: 86 WLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGT 145 L + Y ++ ++ G++ L ++ P V + +P+Y Sbjct: 83 KLSEDF----------YRGFVDAKEIFISDGAKVDLFRLL-SFFGPNQTVAIQDPSYPAY 131 Query: 146 LQSLHPLGCN-IINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPT 204 L G II + + + + PE ++ + + + + NNPT Sbjct: 132 LDIARLTGAKEIIALPCLQE-----------NAFFPEFPEDTHID----ILCLCSPNNPT 176 Query: 205 GNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSK 263 G L ++ + I A +++ LI+ D Y + + + D I +SFSK Sbjct: 177 GTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIPDARFCAIEINSFSK 236 Query: 264 IIS-SGLRIGFLTGPKPL--------IERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG 314 + +G+R+G+ P+ L I+ + + S Q L + Sbjct: 237 PLGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPAQEAGVAGLSILPQ-- 294 Query: 315 FMAHVDRVIDFYSNQKDAILAAADKWLTG-LAEWHVPAAGMFLWIKVKGINDVKELIEE- 372 I +Y D + A H P +LW+K N + + Sbjct: 295 -----LEAIHYYRENSDLLRKALLATGFEVFGGEHAP----YLWVKPTQANISDRDLFDF 345 Query: 373 KAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVL 417 + + + PG F + S ++R S S E + A + L Sbjct: 346 FLREYHIAITPGIGF---GRSGSGFVRFS-SLGKREDILAACERL 386 >1M4N-A nrPDB Length = 435 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 61/387 (15%), Positives = 137/387 (35%), Gaps = 36/387 (9%) Query: 55 VENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVT 114 E + GE + + G+P + ++ + + P+ L +T Sbjct: 63 PEAAAFKKNGESIFAELALFQDYHGLPAFKKAMVDFMAEIRG-NKVTFDPNH----LVLT 117 Query: 115 SGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH-PLGCNIINVASDESGIVPDSLRD 173 +G+ + +PG+ VL+ P Y G + L G I+ + S + + Sbjct: 118 AGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSS----NGFQI 173 Query: 174 ILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY 233 + + + ++N V N +NP G ++T + +I D+ Y Sbjct: 174 TETALEEAYQEAEKRNLRVKGVLVTNPSNPLGTTMTRNELYLLLSFVEDKGIHLISDEIY 233 Query: 234 YFLQFNKFRVPTFLSM----------DVDGRVIRADSFSK-IISSGLRIGFLTGPKPLIE 282 F+ + + + +V RV S SK + G R+G + ++ Sbjct: 234 SGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVGAIYSNDDMVV 293 Query: 283 RVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT 342 + L S+ Q ++S +L + ++ ++ ++ +++ K Sbjct: 294 AAATKMSSFGL-VSSQTQHLLSAMLSD--KKLTKNYIAENHKRLKQRQKKLVSGLQKSG- 349 Query: 343 GLAEWHVPAAGMFLWIKVKGINDVK------ELIEEKAVKMGVLMLPGNAFYVDSSAPSP 396 AG+F W+ ++ + EL ++ ++ + + PG+ Sbjct: 350 --ISCLNGNAGLFCWVDMRHLLRSNTFEAEMELWKKIVYEVHLNISPGS---SCHCTEPG 404 Query: 397 YLRASFSSASPEQMDVAFQVLAQLIKE 423 + R F++ +D+A Q L + E Sbjct: 405 WFRVCFANLPERTLDLAMQRLKAFVGE 431 >5C6U-A nrPDB Length = 435 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 74/406 (18%), Positives = 139/406 (34%), Gaps = 31/406 (7%) Query: 28 RGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWL 87 +G K + L G P+ ++++ + + Y G+P L + Sbjct: 25 QGMKLALDLTRGKPSAEQLDLSNQLLSL---PGDDYRDPEGTDTRNYGGQHGLPGLRAIF 81 Query: 88 KQLQIKLHNPPTIHYPPSQGQM--DLCVTSGSQQGLCKVFEMIIN-PGDNVLLDEPAYSG 144 +L + P I S ++ D+ S G+ I G L P Y Sbjct: 82 AELLG-IAVPNLIAGNNSSLELMHDIVAFSMLYGGVDSPRPWIQEQDGIKFLCPVPGYDR 140 Query: 145 TLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPT 204 +G +I + + G D + +++ K ++TVP NP+ Sbjct: 141 HFAITETMGIEMIPIPMLQDGPDVDLIEELV----------AVDPAIKGMWTVPVFGNPS 190 Query: 205 GNSLTSERKKEIYEL-ARKYDFLIIEDDPY--YFLQFNKFRVPTFLSMDV----DGRVIR 257 G + + E + + ++ DF + D+ Y + L + R L + R Sbjct: 191 GVTYSWETVRRLVQMRTAAPDFRLFWDNAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYV 250 Query: 258 ADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMA 317 S SKI +G + F G I + + ++ P NQL + + +G Sbjct: 251 FASTSKITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDA--DGVRL 308 Query: 318 HVDRVIDFYSNQKDAILAAADKWLTG--LAEWHVPAAGMFLWIKVKGINDVKELIEEKAV 375 H+ R + + + D+ L+ +A W P G F+ + V + A Sbjct: 309 HMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFISLDV--LPGTARRTVALAK 366 Query: 376 KMGVLML-PGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 +G+ + G +F +R + S S + A LA Sbjct: 367 DVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRNAVDGLATC 412 >3QGU-A nrPDB Length = 449 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 66/402 (16%), Positives = 131/402 (32%), Gaps = 48/402 (11%) Query: 33 MISLAGG---LPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQ 89 +ISL G P P A + Y G L + Sbjct: 71 IISLGIGDTTEPLPKYIADAMAKAAAGLATREGYS--------GYGAEQGQGALREAVA- 121 Query: 90 LQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSL 149 + + ++ ++ GS+ + ++ +M+ V + +P+Y + + Sbjct: 122 --STFYGHAG------RAADEIFISDGSKCDIARI-QMMFGSKPTVAVQDPSYPVYVDTS 172 Query: 150 HPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLT 209 +G + D +G D + ++ + K + + NNPTG + T Sbjct: 173 VMMG-----MTGDHNGTGFDGIEYMVCNPDNHFFPDLSKAKRTDIIFFCSPNNPTGAAAT 227 Query: 210 SERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM-DVDGRVIRADSFSKIIS-S 267 + E+ ARK +++ D Y N T + D I SFSK + Sbjct: 228 RAQLTELVNFARKNGSILVYDAAYALYISNPDCPKTIYEIPGADEVAIETCSFSKYAGFT 287 Query: 268 GLRIGFLTGPK--------PLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHV 319 G+R+G+ PK P+ + S Q L G + + Sbjct: 288 GVRLGWTVVPKALKYANGEPVHADWNRVMTTCFNGASNIVQAGGLACLQPEG----LKEM 343 Query: 320 DRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGV 379 + +I FY + + + ++W+ G ++ E + + Sbjct: 344 NAMIKFYKENAQILKTTFTEMG---FSVYGGDDAPYIWVGFPG-KPSWDVFAEILERCNI 399 Query: 380 LMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 + PG+ + A ++RAS + S E + A + + Sbjct: 400 VTTPGSGY---GPAGEGFVRAS-AFGSRENILEAVRRFKEAY 437 >3B1C-A nrPDB Length = 392 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 54/387 (13%), Positives = 130/387 (33%), Gaps = 29/387 (7%) Query: 40 LPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPT 99 +P + P A + E ++ L Y + ELL + + H Sbjct: 28 ETDPQLLPAWIADMDFEVMPEVKQAIHDYAEQLVYGYTYASDELLQAVLDWEKSEHQY-- 85 Query: 100 IHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV 159 S + D+ G + + G+ VL++ P Y +S+ +++ Sbjct: 86 -----SFDKEDIVFVEGVVPAISIAIQAFTKEGEAVLINSPVYPPFARSVRLNNRKLVSN 140 Query: 160 AS-DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYE 218 + +E+G+ + + D K LY + N +NP G E ++I Sbjct: 141 SLKEENGLFQIDFEQLENDIVENDVK---------LYLLCNPHNPGGRVWEREVLEQIGH 191 Query: 219 LARKYDFLIIEDDPYYFLQFNKFRVPTF--LSMDVDGRVIRADSFSKIIS-SGLRIGFLT 275 L +K+ +++ D+ + L +F +S D + S +K + +G + + Sbjct: 192 LCQKHHVILVSDEIHQDLTLFGHEHVSFNTVSPDFKDFALVLSSATKTFNIAGTKNSYAI 251 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILA 335 P + H Q+ H + I+ + ++ + V++ + Sbjct: 252 IENPTLCAQFKHQQLVNNHHEVSSLGYIATETAYRYGKPWLVALKAVLE---ENIQFAVE 308 Query: 336 AADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKA-VKMGVLMLPGNAFYVDSSAP 394 + L + P +W+ + + + V++ G+ + + Sbjct: 309 YFAQEAPRL-KVMKPQGTYLIWLDFSDYGLTDDALFTLLHDQAKVILNRGSDYGSEGEL- 366 Query: 395 SPYLRASFSSASPEQMDVAFQVLAQLI 421 + R + + A ++ + + + Sbjct: 367 --HARLNIA-APKSLVEEICKRIVCCL 390 >4FL0-A nrPDB Length = 456 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 65/423 (15%), Positives = 139/423 (32%), Gaps = 71/423 (16%) Query: 20 RTMTDILSRGPKSMISLAGG---LPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSP 76 R + I +ISL G P P + G ++ Y Sbjct: 59 RELEHIEKHPNVQLISLGTGDTTEPIPEQ--------ITSHMSNFAHGLSTVEGYRGYGL 110 Query: 77 SAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVL 136 G L + + + + ++ V+ G+Q + + ++++ + Sbjct: 111 EQGNKTLRKAIAE---TFYRDLHV------KSNEVFVSDGAQSDISR-LQLLLGSNVTIA 160 Query: 137 LDEPAYSGTLQSLHPLGC------------NIINVASDESGIVPDSLRDILSRWKPEDAK 184 + +P + + S +G N++ + + + + P+ A Sbjct: 161 VQDPTFPAYIDSSVIIGQTGHFHEKTKKYQNVVYMPCGPN-----------NSFFPDLAM 209 Query: 185 NPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVP 244 P+ + + + NNPTG + ++ ++ + A+ +II D Y + Sbjct: 210 TPRTD----VIFFCSPNNPTGYVASRKQLHQLVDFAKTNGSIIIFDSAYAAFIEDGSPRS 265 Query: 245 TFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLI-----ERVILHIQVSTL---HP 295 + I SFSK +G+R+G+ P L+ + ++ T Sbjct: 266 IYEIPGAREVAIEVSSFSKFAGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGA 325 Query: 296 STFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKW-LTGLAEWHVPAAGM 354 S Q L G + + V ++Y + ++ L + P Sbjct: 326 SNIAQAGGLACLSSGG----LKEIRSVNNYYKENRKILMDTLVSLGLKVYGGVNAP---- 377 Query: 355 FLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAF 414 +LW+ KG + ++ E ++ +PG+ F YLR S + + A Sbjct: 378 YLWVHFKG-SKSWDVFNEILENTHIITVPGSGFGPGGEE---YLRIS-GFGRRDHIVEAS 432 Query: 415 QVL 417 + L Sbjct: 433 KRL 435 >3L8A-A nrPDB Length = 421 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 45/339 (13%), Positives = 114/339 (33%), Gaps = 28/339 (8%) Query: 83 LLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAY 142 L + + K H+ + + D+ G + + GD VL++ P Y Sbjct: 101 LYQAVIDWERKEHDYAVV-------KEDILFIDGVVPAISIALQAFSEKGDAVLINSPVY 153 Query: 143 SGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNN 202 +++ ++ + I+ + + + N K +Y + + +N Sbjct: 154 YPFARTIRLNDHRLVE---NSLQIINGRFEIDFEQLEKDIIDNNVK-----IYLLCSPHN 205 Query: 203 PTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV--DGRVIRADS 260 P G ++ +I EL +K+ +++ D+ + L + ++D I S Sbjct: 206 PGGRVWDNDDLIKIAELCKKHGVILVSDEIHQDLALFGNTHHSLNTLDASYKDFTIILSS 265 Query: 261 FSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHV 319 +K + +G + F + R + Q++ MI+ + ++ + Sbjct: 266 ATKTFNIAGTKNSFAIIQNESLRRKFQYRQLANNQHEVPTVGMIATQAAFQYGKPWLEEL 325 Query: 320 DRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAV-KMG 378 VI+ ++ + + P +W+ + + EK + Sbjct: 326 KTVIEG---NIKLVIKELEAKTK--IKVMEPEGTYLVWLDFSAYAIAQPQLSEKLQNEAK 380 Query: 379 VLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVL 417 V++ G F + + R + ++ + A + Sbjct: 381 VVLNDGAHFGKEGKY---FARLNVAT-PKNTVQEALSRI 415 >4DQ6-A nrPDB Length = 391 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 113/315 (35%), Gaps = 21/315 (6%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDS 170 L + G + + + D +++ EP YS + +I Sbjct: 93 LIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQ-------K 145 Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 L + ED +N K+ F+ N +NP G T + K++ ++ K++ II D Sbjct: 146 LENGNYIMDYEDIENKIKDVKLFIL--CNPHNPVGRVWTKDELKKLGDICLKHNVKIISD 203 Query: 231 DPYYFLQFNKFRVPTFLSM--DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILH 287 + + + K + S+ + + I + +K + +GL+ ++ P + Sbjct: 204 EIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIAGLQSSYVVLPDE---KDYKL 260 Query: 288 IQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEW 347 + + S + E + ++ +++ + D + ++ + L + Sbjct: 261 LDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKL-KV 319 Query: 348 HVPAAGMFLWIKVKGINDVKELIEEKAVKMG-VLMLPGNAFYVDSSAPSPYLRASFSSAS 406 P LW+ + E +E V+ G V + GN+F S Y R + + Sbjct: 320 RKPEGTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSF---GIGGSGYQRINLA-CP 375 Query: 407 PEQMDVAFQVLAQLI 421 ++ A + I Sbjct: 376 RSMLEEALIRIKNAI 390 >3EI8-A nrPDB Length = 432 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 74/418 (17%), Positives = 141/418 (33%), Gaps = 51/418 (12%) Query: 20 RTMTDILSRGPKSMISLAGG---LPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSP 76 R +L +ISL G P P + A E + Y Sbjct: 45 RRSAHLLKYPDAQVISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYS--------GYGA 96 Query: 77 SAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVL 136 G L + + + + I G D+ V+ G++ + + +++ + Sbjct: 97 EQGAKPLRAAIAK---TFYGGLGI------GDDDVFVSDGAKCDISR-LQVMFGSNVTIA 146 Query: 137 LDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL-SRWKPEDAKNPQKNTPKF-- 193 + +P+Y + S +G + + +I R PE+ P +T Sbjct: 147 VQDPSYPAYVDSSVIMG------QTGQFNTDVQKYGNIEYMRCTPENGFFPDLSTVGRTD 200 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDG 253 + + NNPTG + T E+ ++ E A+K +I+ D Y + F + Sbjct: 201 IIFFCSPNNPTGAAATREQLTQLVEFAKKNGSIIVYDSAYAMYMSDDNPRSIFEIPGAEE 260 Query: 254 RVIRADSFSKIIS-SGLRIGFLTGPKPLI--------ERVILHIQVSTLHPSTFNQLMIS 304 + SFS +G+R+G+ PK L+ + I S +Q Sbjct: 261 VAMETASFSNYAGFTGVRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFNGASNISQAGAL 320 Query: 305 QLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGIN 364 L G E + +VI FY + I+ D + + + + ++W+ + Sbjct: 321 ACLTPEGLEA----MHKVIGFYKENTNIII---DTFTSLGYDVYGGKNAPYVWVHFPNQS 373 Query: 365 DVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 ++ E K V+ ++R S + E + A + QL K Sbjct: 374 -SWDVFAEILEKTHVVT---TPGSGFGPGGEGFVRVS-AFGHRENILEACRRFKQLYK 426 >3DZZ-A nrPDB Length = 391 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 52/339 (15%), Positives = 115/339 (33%), Gaps = 22/339 (6%) Query: 88 KQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQ 147 + + + I + + SG + + +PGD +L+ EP Y+ Sbjct: 65 AEYYKAVADWEEIEHRARPKEDWCVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYS 124 Query: 148 SLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS 207 + G +I+ W + K + + N +NP G + Sbjct: 125 VIEGNGRRVISSDLIYEN------SKYSVNWADLEEKLATPSVR--MMVFCNPHNPIGYA 176 Query: 208 LTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGR--VIRADSFSKII 265 + E K I EL K+ L+I D+ + L + ++D D + V+ S SK Sbjct: 177 WSEEEVKRIAELCAKHQVLLISDEIHGDLVLTDEDITPAFTVDWDAKNWVVSLISPSKTF 236 Query: 266 S-SGLRIGFLTGP-KPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVI 323 + + L P L R ++ + + + +E G + + Sbjct: 237 NLAALHAACAIIPNPDLRARAEESFFLAGIGEPNLLAIPAAIAAYEEGHDWLRELKQVLR 296 Query: 324 DFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKG-INDVKELIEEKAVKMGVLML 382 D ++ ++ + + + A W+ + + ++ + K G+++ Sbjct: 297 DNFAYAREFLAKEVPE-----VKVLDSNASYLAWVDISALGMNAEDFCKYLREKTGLIIS 351 Query: 383 PGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLI 421 GN + + ++R + + E + Q L Q + Sbjct: 352 AGNGYRGNG---HEFVRINLA-CPKELVIDGMQRLKQGV 386 >5Z0Q-C nrPDB Length = 389 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 60/388 (15%), Positives = 125/388 (32%), Gaps = 42/388 (10%) Query: 42 NPNMFPFKTAVITVENGKTI--QFGEEMMKRALQYSPSAGIPELLSWLKQLQ-IKLHNPP 98 + ++ P A I + + + Y ++ L ++ ++ + Sbjct: 32 DRDILPLWIADTDFRAADCIIDALQQRVQQGVFGYGVTS------EALAEVAIERMESRF 85 Query: 99 TIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIIN 158 P L G G+ + + P Y + G ++ Sbjct: 86 GWKIQPEW----LVFLPGVVTGINIAVRAFTEAHQSTVSATPIYPPFFLAPKLAGRQHLS 141 Query: 159 VASDESGIVPDSLRDILSRWKPEDAKNPQKNT-PKFLYTVPNGNNPTGNSLTSERKKEIY 217 A LR RW + + + + + L + N +NP G + + Sbjct: 142 AA----------LRLEQQRWVLDLDSHEDRMSGNEKLLLLCNPHNPGGTVYRRKELEAQL 191 Query: 218 ELARKYDFLIIEDDPYYFLQFN-KFRVPTFLSM--DVDGRVIRADSFSKIIS-SGLRIGF 273 A+++D L+ D+ + L + F S+ D R I S SK + +GL Sbjct: 192 RFAQRHDLLVCSDEIHCDLVLEPGVQHIPFASLSDDAAQRSITLMSPSKSFNIAGLGASL 251 Query: 274 LTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAI 333 P P + ++ + + + G+ +D +D+ +D + Sbjct: 252 AVIPNPELRARFNRMRKGMVPDVDVLAYVAASAAWREGQ----PWLDAQLDYLRANRDML 307 Query: 334 LAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSA 393 ++ L GL+ P A WI G+ + K G+ G F D Sbjct: 308 AQHVNR-LPGLSMVT-PEASFLGWIDASGLGVADPAL--FFEKHGLGFSSGRDFGND--- 360 Query: 394 PSPYLRASFSSASPEQMDVAFQVLAQLI 421 ++R +F + ++ A Q + + + Sbjct: 361 --RFVRFNFG-CPRQLLEEALQRMTRAL 385 >3EZS-A nrPDB Length = 376 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 67/416 (16%), Positives = 137/416 (32%), Gaps = 65/416 (15%) Query: 19 IRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSA 78 +R + ++ + + L G P F + Y SA Sbjct: 12 LRALLKEITPKKRGL-DLGIGEPQFETPKF-----------IQDALKNHTHSLNIYPKSA 59 Query: 79 GIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII----NPGDN 134 L + + + + +L T GS++ L ++ NP Sbjct: 60 FEESLRAAQRGFFKRRFKI-------ELKENELISTLGSREVLFNFPSFVLFDYQNP--T 110 Query: 135 VLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFL 194 + P Y + + + + + SL + + L Sbjct: 111 IAYPNPFYQIYEGAAKFIKAKSLLMPLTKENDFTPSLNEKELQEVD-------------L 157 Query: 195 YTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSM----- 249 + + NNPTG +L+ E +LA K+DF++I D+ Y + + P+ L Sbjct: 158 VILNSPNNPTGRTLSLEELISWVKLALKHDFILINDECYSEI-YENTPPPSLLEACMLAG 216 Query: 250 -DVDGRVIRADSFSK-IISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLL 307 + V+ S SK + GLR GF+ G L+E+ + + Sbjct: 217 NEAFKNVLVIHSLSKRSSAPGLRSGFIAGDSRLLEKYKAFRAYLGYTS--------ANAI 268 Query: 308 HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVK 367 + E ++ DR +F+ N L A K P ++++ V+ + Sbjct: 269 QKASEAAWLD--DRHAEFFRNIYANNLKLARKIFKN--TLIYPY-SFYVYLPVQNG---E 320 Query: 368 ELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 + G++ LP + + Y+R + +P ++ +++ + +E Sbjct: 321 NFAKTLYQNEGIITLPALYLGRNR-IGADYVRLALVYDTP-LLEKPLEII-ETYRE 373 >3IHJ-A nrPDB Length = 498 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 56/403 (13%), Positives = 133/403 (33%), Gaps = 61/403 (15%) Query: 62 QFGEEMMKRALQ---------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLC 112 + ++ +R LQ YS S G+ + + + + P ++ Sbjct: 104 EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDG--GVPADPD----NIY 157 Query: 113 VTSGSQQGLCKVFEMIINPGDN----VLLDEPAYSGTLQSLHPLGCNIINVASDESGIVP 168 +T+G+ G+ + +++++ G V++ P Y + L +N DE Sbjct: 158 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEE---- 213 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 + ++ + + PK L + N NPTG + + +++ A + ++ Sbjct: 214 NCWALNVNELRRAVQEAKDHCDPKVL-CIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLL 272 Query: 229 EDDPYYFLQFN-KFRVPTF--------LSMDVDGRVIRADSFSKIISS--GLRIGFL--- 274 D+ Y ++ R +F + + S SK G R G++ Sbjct: 273 ADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVI 332 Query: 275 TGPKPLIERVILHIQVSTLHPSTFNQLMIS-----QLLHEWGEEGFMAHVDRVIDFYSNQ 329 + +++ + V L P Q + + E E F + V+ + + Sbjct: 333 NLHPEIKGQLVKLLSVR-LCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKK 391 Query: 330 KDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKE------------LIEEKAVKM 377 + G+ + M+ + ++ E + + Sbjct: 392 AKLT-EDLFNQVPGI-HCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEET 449 Query: 378 GVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 G+ ++PG+ F + + R + E++ Q + Sbjct: 450 GICVVPGSGFG--QREGTYHFRMTI-LPPVEKLKTVLQKVKDF 489 >3TCM-A nrPDB Length = 500 Score = 114 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 66/383 (17%), Positives = 136/383 (35%), Gaps = 49/383 (12%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII-NPG 132 YS S GI L + P D+ +T G+ G+ + +++I N Sbjct: 130 YSHSQGIHGLRDAIASGIASRDGFPA-------NADDIFLTDGASPGVHLMMQLLIRNEK 182 Query: 133 DNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPK 192 D +L+ P Y S+ G ++ +ES L + + EDA++ N Sbjct: 183 DGILVPIPQYPLYSASIALHGGALVPYYLNES--TGWGLETSDVKKQLEDARSRGINVRA 240 Query: 193 FLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYF-LQFNKFRVPTFLSM-- 249 V N NPTG L E + +I + + +++ D+ Y + + + +F + Sbjct: 241 --LVVINPGNPTGQVLAEENQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKIVR 298 Query: 250 -----DVDGRVIRADSFSKII--SSGLRIGF--LTG-PKPLIERVILHIQVSTLHPSTFN 299 + D ++ S SK G R G+ +TG P+ E++ V L + Sbjct: 299 SLGYGEEDLPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKIASV-NLCSNITG 357 Query: 300 QLMISQL-----LHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGM 354 Q++ S + + + A D ++ + + A+ A +K + M Sbjct: 358 QILASLVMNPPKASDESYASYKAEKDGILASLARRAKALEHAFNKL--EGITCNEAEGAM 415 Query: 355 FLWIKVKGINDVKE------------LIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASF 402 +++ ++ E G++++PG+ F + + R Sbjct: 416 YVFPQICLPQKAIEAAKAANKAPDAFYALRLLESTGIVVVPGSGFG--QVPGTWHFR-CT 472 Query: 403 SSASPEQMDVAFQVLAQLIKESL 425 +++ + E+ Sbjct: 473 ILPQEDKIPAVISRF-TVFHEAF 494 >3T32-A nrPDB Length = 383 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 40/297 (13%), Positives = 99/297 (33%), Gaps = 17/297 (5%) Query: 101 HYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVA 160 Y + + ++G L + ++VL+ P Y ++ Sbjct: 75 QYNWDIQKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPF--------FEMVTTN 126 Query: 161 SDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA 220 + + + P ++ E + + K + + + +NP G E ++ L Sbjct: 127 NRQLCVSPLQKQNDTYAIDFEHLEKQFQQGVKLML-LCSPHNPIGRVWKKEELTKLGSLC 185 Query: 221 RKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD--GRVIRADSFSKIIS-SGLRIGFLTGP 277 KY+ +++ D+ + + + F S+ + R I + SK + +GL+ + P Sbjct: 186 TKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQASIIIIP 245 Query: 278 KPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAA 337 + + IQ N + + + E ++ + + + Sbjct: 246 NEKLRQAFTSIQYR-QGFHGLNIFAYTAMQSAYTE--CNDWLNEIRFYIEDNAKFACEYI 302 Query: 338 DKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLML-PGNAFYVDSSA 393 + L P LWI +N ++ + + G +++ PG + + Sbjct: 303 KDHIPTL-SVMKPEGSFLLWIDCSALNLSQDERTKLLEEKGKIIVEPGEKYGLGGEE 358 >1D2F-A nrPDB Length = 390 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 53/388 (13%), Positives = 128/388 (32%), Gaps = 38/388 (9%) Query: 44 NMFPFKTAVITVENGKTI--QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIH 101 ++ PF + + I + +M YS E L+ + H Sbjct: 29 DLLPFTISDMDFATAPCIIEALNQRLMHGVFGYSRWKND-EFLAAIAHWFSTQHYTAIDS 87 Query: 102 YPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS 161 G + + S ++ G+ V++ PAY +++ ++ VA Sbjct: 88 QTVVYGPSVIYMVS-------ELIRQWSETGEGVVIHTPAYDAFYKAIEGNQRTVMPVAL 140 Query: 162 DE--SGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYEL 219 ++ G D + KPE + + + NPTG T + + + +L Sbjct: 141 EKQADGWFCDMGKLEAVLAKPECK----------IMLLCSPQNPTGKVWTCDELEIMADL 190 Query: 220 ARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS----SGLRIGFLT 275 ++ +I D+ + + + + + ++ + S SK + +G G + Sbjct: 191 CERHGVRVISDEIHMDMVWGEQPHIPWSNVARGDWAL-LTSGSKSFNIPALTGA-YGIIE 248 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILA 335 + L + L ++ G +D + + + I Sbjct: 249 NSSSRDAYLSALKGRDGLSSPSVLALTAHIAAYQQGA----PWLDALRIYLKDNLTYIAD 304 Query: 336 AADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKM-GVLMLPGNAFYVDSSAP 394 + L W +P + W+ ++ +N +++ ++ V ++PG Y Sbjct: 305 KMNAAFPEL-NWQIPQSTYLAWLDLRPLNIDDNALQKALIEQEKVAIMPG---YTYGEEG 360 Query: 395 SPYLRASFSSASPEQMDVAFQVLAQLIK 422 ++R + + +++ L I+ Sbjct: 361 RGFVRLN-AGCPRSKLEKGVAGLINAIR 387 >1C7O-A nrPDB Length = 399 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 57/383 (14%), Positives = 122/383 (31%), Gaps = 40/383 (10%) Query: 48 FKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQG 107 FK +E K + + + L Y+ E +K+ H Sbjct: 43 FKNPPELIEGLK-----KYLDETVLGYTGPT--EEYKKTVKKWMKDRHQW-------DIQ 88 Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIV 167 + T+G + PGD V++ P Y ++ II E Sbjct: 89 TDWIINTAGVVPAVFNAVREFTKPGDGVIIITPVYYPFFMAIKNQERKIIECELLEKDGY 148 Query: 168 PDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLI 227 L + + + +NP G + ++I ++ K D ++ Sbjct: 149 YTIDFQKLEKLSKDKNNKA--------LLFCSPHNPVGRVWKKDELQKIKDIVLKSDLML 200 Query: 228 IEDDPYYFLQFNKFRVPTFLSMDVD--GRVIRADSFSKIIS-SGLRIG-FLTGPKPLIER 283 D+ ++ L + F S+D + I + SK + +G+ + + + ER Sbjct: 201 WSDEIHFDLIMPGYEHTVFQSIDEQLADKTITFTAPSKTFNIAGMGMSNIIIKNPDIRER 260 Query: 284 VILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTG 343 ++ P T ++ ++ + ++ +VID D + Sbjct: 261 FTKSRDATSGMPFTTLGYKACEICYKECGK-WLDGCIKVIDKNQRIVK------DFFEVN 313 Query: 344 LAEWHVP--AAGMFLWIKVKGINDVKELIEEKAV-KMGVLMLPGNAFYVDSSAPSPYLRA 400 E P WI + + + +EE + K + G F + R Sbjct: 314 HPEIKAPLIEGTYLQWIDFRALKMDHKAMEEFMIHKAQIFFDEGYIF---GDGGIGFERI 370 Query: 401 SFSSASPEQMDVAFQVLAQLIKE 423 + ++ S + + + L + +K+ Sbjct: 371 NLAAPSS-VIQESLERLNKALKD 392 >3FDB-A nrPDB Length = 377 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 67/367 (18%), Positives = 118/367 (32%), Gaps = 44/367 (11%) Query: 62 QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHN----PPTIHYPPSQGQMDLCVTSGS 117 + + + A Y P + L + + P I P + Sbjct: 44 AITDAVQREAFGYQPDGSL--LSQATAEFYADRYGYQARPEWIFPIPDVVR--------- 92 Query: 118 QQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSR 177 GL + V++ PAY L A+ GI D+ ++ Sbjct: 93 --GLYIAIDHFTPAQSKVIVPTPAYPPFFHLLS---------ATQREGIFIDAT-GGINL 140 Query: 178 WKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQ 237 E + + N NP G E E+ +LA +YD ++ D+ + L Sbjct: 141 HDVEKGFQAGARS----ILLCNPYNPLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLV 196 Query: 238 FNKFRVPTFLSMDVDGRV-IRADSFSKIIS-SGLRIG-FLTGPKPLIERVILHIQVSTLH 294 F+ D V I + SK + +GL+ + E V Sbjct: 197 FDGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSNPSDAEHWQQLSPVIKDG 256 Query: 295 PSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGM 354 ST L+ ++ + +G + V + N D +L K + G A+ A Sbjct: 257 ASTLG-LIAAEAAYRYGTDFLNQEVA----YLKNNHDFLLHEIPKRIPG-AKITPMQATY 310 Query: 355 FLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAF 414 +WI + E K V M G F + + R +F++ S E ++ A Sbjct: 311 LMWIDFRDTTIEGSPSEFFIEKAKVAMNDGAWF---GEDGTGFCRLNFAT-SREVLEEAI 366 Query: 415 QVLAQLI 421 +A+ + Sbjct: 367 DRMAKAV 373 >4R2N-A nrPDB Length = 367 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 59/374 (15%), Positives = 118/374 (31%), Gaps = 47/374 (12%) Query: 58 GKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPP-----------TIHYPPSQ 106 GKT+ ++ + P +P + + + + ++ P H P Sbjct: 19 GKTVPGAIKLASNETVFGP---LPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDF 75 Query: 107 GQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGI 166 + V GS ++ ++ + GD V+ ++ + G I V + Sbjct: 76 APEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTF 135 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFL 226 ++ ++ L V N NNPT + + E + L Sbjct: 136 DLYAMLATVTDRTR-------------LIFVCNPNNPTSTVVGPDALARFVEAVPAH-IL 181 Query: 227 IIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVI 285 I D+ Y + R + + V+ +FSK +GLRIG+ G +I + Sbjct: 182 IAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALD 241 Query: 286 LHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLA 345 S+ Q L E + D ++ + A L Sbjct: 242 KV--YVPFTVSSIGQAAAIASLDAADE------LLARTDTVVAERARVSAELRAAGFTL- 292 Query: 346 EWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNA----FYVDSSAPSPYLRAS 401 P+ F+W+ + ++ +E+ A V+ G +LR + Sbjct: 293 ---PPSQANFVWL--PLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFA 347 Query: 402 FSSASPEQMDVAFQ 415 S +++ A + Sbjct: 348 RRWRSDQKLAAALE 361 >1IJI-A nrPDB Length = 356 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 85/236 (36%), Gaps = 27/236 (11%) Query: 107 GQMDLCVTSGSQQGLCKVFEMIINPG-DNVLLDEPAYSGTLQSLHPLGCNIINVASDESG 165 + V+ G+ +G+ + PG D +L P Y S +G V + Sbjct: 74 KPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPT---- 129 Query: 166 IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDF 225 L W+ + K + V + NNPTG + + + + EL R Sbjct: 130 ---------LDNWQLDLQGISDKLDGVKVVYVCSPNNPTGQLINPQDFRTLLELTRG-KA 179 Query: 226 LIIEDDPYYFLQFNKFRVPTFLS-MDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIER 283 +++ D+ Y + + + + SK + +GLR GF + +I Sbjct: 180 IVVADEAYIEF----CPQASLAGWLAEYPHLAILRTLSKAFALAGLRCGFTLANEEVINL 235 Query: 284 VILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADK 339 ++ ++ ST + +Q L G V ++I ++ ++AA + Sbjct: 236 LMKV--IAPYPLSTPVADIAAQALSPQGIVAMRERVAQIIAE----REYLIAALKE 285 >2X5F-A nrPDB Length = 430 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 74/371 (19%), Positives = 135/371 (36%), Gaps = 51/371 (13%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y+P GI EL +Q L + P + VT+ GL V ++ +N D Sbjct: 84 YAPPQGIEELRDLWQQ--KMLRDNPELSIDNMSRP---IVTNALTHGLSLVGDLFVNQDD 138 Query: 134 NVLLDEPAYSGTLQSL---HPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 +LL E + + + + DSL + L + + Sbjct: 139 TILLPEHNWGNYKLVFNTRNGANLQTYPIFDKDGHYTTDSLVEALQSYNKD--------- 189 Query: 191 PKFLYTVPNGNNPTGNSLTSER----KKEIYELARK-YDFLIIEDDPYYFLQFNKFRVPT 245 K + + NNPTG + T + + I LA K + + DD YY L + + Sbjct: 190 -KVIMILNYPNNPTGYTPTHKEVTTIVEAIKALANKGTKVIAVVDDAYYGLFYEDVYTQS 248 Query: 246 FLSMDVDGRV-----IRADSFSKIISS-GLRIGFLT------GPKPLIER-VILHIQVST 292 + + IR D +K + G R+GF+T K ++E V I+ + Sbjct: 249 LFTALTNLHSNAILPIRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVLEAKVKGLIRSNI 308 Query: 293 LHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAA--ADKWLTGLAEWHVP 350 Q + +L + F +++ I + + AD++ + + Sbjct: 309 SSGPLPTQSAVKHVLKNNKQ--FDKEIEQNIQTLKERYEVTKEVVYADQYHSHWQAYDF- 365 Query: 351 AAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQM 410 +G F+ IKV + D + L + K + ++ NA +R +FS + + Sbjct: 366 NSGYFMAIKVHDV-DPEALRKHLIDKYSIGVIALNA---------TDIRIAFSCVEKDDI 415 Query: 411 DVAFQVLAQLI 421 F +A+ I Sbjct: 416 PHVFDSIAKAI 426 >4EMY-A nrPDB Length = 413 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 63/414 (15%), Positives = 130/414 (31%), Gaps = 57/414 (13%) Query: 25 ILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELL 84 I G +++I+ A G I + E Y+P G + Sbjct: 31 IEKYGREAVINAALG-----TLLDDKGKIIALPSVYDRLDEMDRSHIASYAPIEGEKDYR 85 Query: 85 SWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSG 144 + + P + T G + ++ GD ++ + ++ Sbjct: 86 KIVIDTLFGPYKPEGY--------ISAIATPGGTGAIRSAIFSYLDEGDPLICHDYYWAP 137 Query: 145 TLQSLHPLG--CNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNN 202 + G +D+ D ++ + + + GNN Sbjct: 138 YRKICEEFGRNFKTFEFFTDDFAFNIDVYKEAIDEGIRDSDRIAS-------LINSPGNN 190 Query: 203 PTGNSLTSERKKEIYELA------RKYDFLIIEDDPYYFLQFNKFR----VPTFLSMDVD 252 PTG SL+ E E+ + +I D Y + + F ++ + Sbjct: 191 PTGYSLSDEEWDEVITFLKEKAEDKDKKITLIVDVAYLEFAGDGDQQRKFFEKFSNLPRN 250 Query: 253 GRVIRADSFSKIISS-GLRIGFLTG---PKPLIERVILHIQVSTLH----PSTFNQLMIS 304 V+ A S SK ++ GLR G G K +IE + S + Q ++ Sbjct: 251 LFVVVAFSMSKSHTAYGLRSGAAVGISSSKEIIEEFEASLAHSARCNWSNGTHAAQNILI 310 Query: 305 QLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGIN 364 +L ++ + + + + ++ D + AA + + + G F +I Sbjct: 311 ELERAENKKIYEQELVDLRNMLKSRADVFVTAAKENKLTMIPYF---GGFFTFIPTDKAF 367 Query: 365 DVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLA 418 D+ + +E K + +P + +R + E++ Q LA Sbjct: 368 DIVKDLE----KENIFTIP----------SAKGIRVAICGVGEEKIPKLVQRLA 407 >3EUC-A nrPDB Length = 367 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 85/276 (30%), Gaps = 29/276 (10%) Query: 107 GQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGI 166 M++ + +GS + + + PG V+ P + S G + V Sbjct: 84 AGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRADF- 142 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKY--D 224 + + NNPTGN + + I A+ Sbjct: 143 ----------TLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQGSVCR 192 Query: 225 FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERV 284 L++ D+ Y + + G ++ + SK+ +G+R+G++ G +E++ Sbjct: 193 SLVVVDEAYQPFAQESW----MSRLTDFGNLLVMRTVSKLGLAGIRLGYVAGDPQWLEQL 248 Query: 285 ILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGL 344 +L E + HV + + + + A+ Sbjct: 249 DKVR-----------PPYNVNVLTEATALFALEHVAVLDEQAAQLRAERSRVAEGMAAHG 297 Query: 345 AEWHVPAAGMFLWIKVKGINDV-KELIEEKAVKMGV 379 P+A FL +V L+ K + V Sbjct: 298 GVTVFPSAANFLLARVPDAAQTFDRLLARKVLIKNV 333 >3LY1-A nrPDB Length = 354 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 63/387 (16%), Positives = 133/387 (34%), Gaps = 42/387 (10%) Query: 39 GLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPP 98 G P F +N I F E + + + +A + + L Sbjct: 1 GETQPESAAFTAPST--DNPIRINFNENPLGMSPKAQAAARDAVVKANRYAKNEILMLGN 58 Query: 99 TIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIIN 158 + + +T+GS +G+ E + +++ E Y G + Sbjct: 59 KLAAHHQVEAPSILLTAGSSEGIRAAIEAYASLEAQLVIPELTYGDGEHFAKIAGMKVTK 118 Query: 159 VASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYE 218 V ++ + A + P +Y V N NNPTG ++ + Sbjct: 119 VKMLDNWAF---------DIEGLKAAVAAYSGPSIVYLV-NPNNPTGTITPADVIEPWIA 168 Query: 219 LARKYDFLIIEDDPYYFLQFN-KFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTG 276 ++ + + I D+ Y + +FR + + +I +FSKI + +G+R+G+ Sbjct: 169 -SKPANTMFIVDEAYAEFVNDPRFRSISPMITQGAENIILLKTFSKIHAMAGMRVGYAVA 227 Query: 277 PKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAA 336 +I + ++ ++ S + L + F+ + + D + +L A Sbjct: 228 HPTVIALMGRYVAGEKINFSGVD-----AALASMNDSAFITYSKKSNDV---SRQILLKA 279 Query: 337 ADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP 396 + L ++P+ G F++ ++ + GVL+ G AF Sbjct: 280 LE----DLKLPYLPSEGNFVFHQLVVPLKDY---QTHMADAGVLI--GRAFPP----ADN 326 Query: 397 YLRASFSSASPEQMDVAFQVLAQLIKE 423 + R S + Q +A ++E Sbjct: 327 WCRISLGTPQE------MQWVADTMRE 347 >3CQ5-A nrPDB Length = 369 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 69/384 (17%), Positives = 131/384 (34%), Gaps = 58/384 (15%) Query: 42 NPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIH 101 N N +P A++ + E+ + P EL L K Sbjct: 38 NENPYPPSEALVADLVATVDKIATELNRY-----PERDAVELRDELAAYITKQTGV---- 88 Query: 102 YPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS 161 + + +L +GS + L ++ + PG L +P+YS I V+ Sbjct: 89 ---AVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSR 145 Query: 162 DESG-IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA 220 I D + + +P+ + V NNPTG+ + + + I +A Sbjct: 146 GADFRIDMDVALEEIRAKQPD------------IVFVTTPNNPTGDVTSLDDVERIINVA 193 Query: 221 RKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKII-SSGLRIGFLTGPKP 279 ++I D+ Y F+ T L +++ + + SK +G R+G+ Sbjct: 194 PG---IVIVDEAYAE--FSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYFVANPA 248 Query: 280 LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADK 339 I+ V+L H S +Q L A ++ S ++ + A + Sbjct: 249 FIDAVMLVR--LPYHLSALSQAAAIVALRHS------ADTLGTVEKLSVERVRVAARLE- 299 Query: 340 WLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKA-VKMGVLMLPGNAFYVDSSAPSPYL 398 L VP+ F++ + + +A + GVL+ + +L Sbjct: 300 ---ELGYAVVPSESNFVFF----GDFSDQHAAWQAFLDRGVLI--------RDVGIAGHL 344 Query: 399 RASFSSASPEQMDVAFQVLAQLIK 422 R + E+ D A++IK Sbjct: 345 RTTIGVP--EENDAFLDAAAEIIK 366 >1UU1-A nrPDB Length = 335 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 38/254 (14%), Positives = 81/254 (31%), Gaps = 42/254 (16%) Query: 107 GQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGI 166 + ++ V +G+ + + + M D + P YS +G + V + Sbjct: 75 SKNNVSVGNGADEIIYVMMLMF----DRSVFFPPTYSCYRIFAKAVGAKFLEVPLTKDLR 130 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFL 226 +P+ + +PN NNPTG+ E + I K Sbjct: 131 IPEVNVGEGD-----------------VVFIPNPNNPTGHVFEREEIERIL----KTGAF 169 Query: 227 IIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVI 285 + D+ YY F+ F + + +FSK S + R+G++ + I+ Sbjct: 170 VALDEAYYE--FHGESYVDF--LKKYENLAVIRTFSKAFSLAAQRVGYVVASEKFIDAYN 225 Query: 286 LHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLA 345 + S +Q+ L + F +++ + +A + Sbjct: 226 RVR--LPFNVSYVSQMFAKVAL------DHREIFEERTKFIVEERERMKSALREMG---Y 274 Query: 346 EWHVPAAGM-FLWI 358 F+++ Sbjct: 275 RITDSRGNFVFVFM 288 >3FKD-A nrPDB Length = 350 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 49/316 (15%), Positives = 103/316 (32%), Gaps = 47/316 (14%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDS 170 + VT+G ++ + G L+ P+++ + + S+E D Sbjct: 70 ILVTNGPTAAFYQIAQAF--RGSRSLIAIPSFAEYEDACRMYEHEVCFYPSNEDIGEAD- 126 Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 ++ W + N NNP G L + D + D Sbjct: 127 FSNMDFCW------------------LCNPNNPDGRLLQRTEILRLLN--DHPDTTFVLD 166 Query: 231 DPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQ 289 Y + F V + ++ SFS GLRIG++ K ++RV Sbjct: 167 QSY--VSFTTEEVIRPADIKGRKNLVMVYSFSHAYGIPGLRIGYIVANKDFMKRVAAFS- 223 Query: 290 VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAI--LAAADKWLTGLAEW 347 ++ L E + + + Q++ + + A ++ E Sbjct: 224 ---------TPWAVNALAIEAAKFILIHPAQFTLPIRKWQRNTVDFITALNRL--DGVEV 272 Query: 348 HVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASP 407 H P+ F +++K EL + + +L+ + F + Y+R + + Sbjct: 273 H-PSGTTFFLLRLKKGT-AAELKKYMLEEYNMLIRDASNFRGLDES---YVRITTQRPAQ 327 Query: 408 EQMDVAFQVLAQLIKE 423 Q+ + L +++ Sbjct: 328 NQLF--IKALETFLEK 341 >2ZY2-A nrPDB Length = 544 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 67/430 (15%), Positives = 137/430 (31%), Gaps = 83/430 (19%) Query: 59 KTIQFGEEMMKRALQ--YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 F EM+ L Y + + + + I + PP +DL G Sbjct: 116 DPAAFLHEMVDGILGCNYPVPPRMLTVSEQIVRQYI-VREMAGGAVPPE--SVDLFAVEG 172 Query: 117 SQQGLCKVFEMI-----INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSL 171 + +FE + + GD V + P ++ ++ ++ V PD Sbjct: 173 GTAAMAYIFESLRISGLLKAGDKVAIGMPVFTPYIEIPELAQYDLKEVPI---HADPD-- 227 Query: 172 RDILSRWKPEDAKNPQKNTPKFLYTVP-NGNNPTGNSLTSERKKEIYELARKY--DFLII 228 + W+ DA+ + P N +NP + + + + D LI+ Sbjct: 228 ----NGWQYSDAELDKLKDPDVKIFFCVNPSNPPSVKMDQRSLDRVRAIVAEQRPDLLIL 283 Query: 229 EDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKII-SSGLRIGFLTGPKPLI------ 281 DD Y + S+ + SFSK ++G R+G + K + Sbjct: 284 TDDVYGTF---ADEFQSLFSV-CPRNTLLVYSFSKYFGATGWRLGVIAAHKDNVFDHALS 339 Query: 282 -----ERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGF------------------MAH 318 + L + +L P + I +L+ + + Sbjct: 340 QLPESAKKALDHRYRSLLPDVRSLKFIDRLVADSRVVALNHTAGLSTPQQVQMVLFSLFA 399 Query: 319 VDRVIDFYSNQKDAILAAADKWL---TGLAEWHVPAAG-MFLWIKVKGI----------- 363 + D Y ++ + L G+ P + + I ++ + Sbjct: 400 LMDEADAYKQALKQLIRRREATLYRELGMPPLENPNSVNYYTLIDLQNVTCRLYGEAFSQ 459 Query: 364 -----NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQ---MDVAFQ 415 + +++ A + G+++LPG F D + RAS ++ + + + A + Sbjct: 460 WAVQQSSTGDMLFRVADETGIVLLPGRGFGSDRPSG----RASLANLNEYEYAAIGRALR 515 Query: 416 VLAQLIKESL 425 LA + E Sbjct: 516 RLADELYEQY 525 >3FDD-A nrPDB Length = 533 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 55/411 (13%), Positives = 128/411 (31%), Gaps = 91/411 (22%) Query: 80 IPELLSWLKQLQIKLHNPPTIHYPPSQGQM-DLCVTSGSQQGLCKVFEM-----IINPGD 133 +P + + + ++ + + + +L G + +FE ++ GD Sbjct: 136 VPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESMKVNGLLKAGD 195 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 V + P ++ ++ + VA + + W+ D++ + P Sbjct: 196 KVAIGMPVFTPYIEIPELAQYALEEVAINADPAL---------NWQYPDSELDKLKDPAI 246 Query: 194 LYTVP-NGNNPTGNSLTSERKKEIYELARKY--DFLIIEDDPYYFLQFNKFRVPTFLSMD 250 N +NP + + + ++ ++ D +I+ DD Y F + ++ Sbjct: 247 KIFFCVNPSNPPSVKMDERSLERVRKIVAEHRPDLMILTDDVYG--TFADG-FQSLFAI- 302 Query: 251 VDGRVIRADSFSKII-SSGLRIGFLTGPKPLI---------------------------- 281 + SFSK ++G R+G + K I Sbjct: 303 CPANTLLVYSFSKYFGATGWRLGVVAAHKENIFDLALGRLPESEKTALDDRYRSLLPDVR 362 Query: 282 -----------ERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 R + + L Q+ + L E H + ++ Sbjct: 363 SLKFLDRLVADSRAVALNHTAGLSTPQQVQMTLFSLFALMDESDQYKH---TLKQLIRRR 419 Query: 331 DAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI----------------NDVKELIEEKA 374 +A L E V + I ++ + + +++ A Sbjct: 420 EATLYRELGTPPQRDENAV---DYYTLIDLQDVTSKLYGEAFSKWAVKQSSTGDMLFRIA 476 Query: 375 VKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQ---MDVAFQVLAQLIK 422 + G+++LPG F D + RAS ++ + + + A + +A + Sbjct: 477 DETGIVLLPGRGFGSDRPSG----RASLANLNEYEYAAIGRALRQMADELY 523 >2ZY3-A nrPDB Length = 546 Score = 88.7 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 52/411 (12%), Positives = 127/411 (30%), Gaps = 85/411 (20%) Query: 80 IPELLSWLKQLQIKLHNPPTIHYPPSQGQM-DLCVTSGSQQGLCKVFEMI-----INPGD 133 +P + + + ++ + + + +L G + +FE + + GD Sbjct: 136 VPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGD 195 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 V + P ++ ++ + VA + D W+ D++ + P Sbjct: 196 KVAIGMPVFTPYIEIPELAQYALEEVAIN---------ADPSLNWQYPDSELDKLKDPAI 246 Query: 194 LYTVP-NGNNPTGNSLTSERKKEIYELARKY--DFLIIEDDPYYFLQFNKFRVPTFLSMD 250 N +NP + + + + ++ D +I+ DD Y + + Sbjct: 247 KIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYGTFADDFQSLFAIC--- 303 Query: 251 VDGRVIRADSFSKII-SSGLRIGFLTGPKPLI-----------ERVILHIQVSTLHPSTF 298 + SFSK ++G R+G + + + E+V L + +L P Sbjct: 304 -PENTLLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHRYRSLLPDVR 362 Query: 299 N-------------------------QLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAI 333 + Q + L + + +++ Sbjct: 363 SLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLKQLIRRRETT 422 Query: 334 LAAADKWLTGLAEWHVPAAGMFLWIKVKGI----------------NDVKELIEEKAVKM 377 L E V + I ++ + + +++ A + Sbjct: 423 LYRELGMPPLRDENAV---DYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGDMLFRIADET 479 Query: 378 GVLMLPGNAFYVDSSAPSPYLRASFSSASPEQ---MDVAFQVLAQLIKESL 425 G+++LPG F + + RAS ++ + + + A + +A + Sbjct: 480 GIVLLPGRGFGSNRPSG----RASLANLNEYEYAAIGRALRKMADELYAEY 526 >3F6T-A nrPDB Length = 533 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 62/378 (16%), Positives = 118/378 (31%), Gaps = 79/378 (20%) Query: 108 QMDLCVTSGSQQGLCKVFEMI-----INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASD 162 Q DL T G + F + + GD + ++EP ++ L+ ++ V Sbjct: 164 QTDLFPTEGGTAAIVYAFHSLAENHLLKKGDKIAINEPIFTPYLRIPELKDYELVEV--- 220 Query: 163 ESGIVPDSLRDILSRWKPEDAKNPQKNTPKFL-YTVPNGNNPTGNSLTSERKKEIYELAR 221 D + W+ E + + P V N NPT + I + Sbjct: 221 ------DLHSYEKNDWEIEPNEIEKLKDPSIKALIVVNPTNPTSKEFDTNALNAIKQAVE 274 Query: 222 KYD-FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPK- 278 K +II D+ Y N + + + + S+SK+ +G R+G + + Sbjct: 275 KNPKLMIISDEVYGAFVPNFKSIYSVVPY----NTMLVYSYSKLFGCTGWRLGVIALNEK 330 Query: 279 ----PLIERVIL--HIQ------------------------------VSTLHPSTFNQLM 302 I + Q T ST Q+M Sbjct: 331 NVFDDNIAHLDKVELRQLHKRYSSVVLDPDKMKFIDRLCADSRSIGLYHTAGLSTPQQIM 390 Query: 303 -----ISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTG---------LAEWH 348 ++ LL ++D S + D + A L + + Sbjct: 391 EALFSMTHLLTSTNGGSDDPYIDIARKLVSERYDQLHDAMQAPKDETDTNTHYYSLIDIY 450 Query: 349 VPAAGMF---LWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA 405 A ++ + + + + + A K GV+++ G F LR S ++ Sbjct: 451 RLAEKIYGKEFRDYLTNNFEQVDFLLKLAEKNGVVLVDGVGFGA----KPGELRVSQANL 506 Query: 406 SPEQMDVAFQVLAQLIKE 423 E + + + +L+KE Sbjct: 507 PTEDYALIGKQVLELLKE 524 >3FSL-A nrPDB Length = 397 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 63/415 (15%), Positives = 137/415 (33%), Gaps = 41/415 (9%) Query: 9 AASAARNPSPIRTMTDILSRGPK-SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEM 67 A PI T+ + P+ ++L+ GL E Sbjct: 3 QKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAE---AEARLNAQ 59 Query: 68 MKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEM 127 A Y P G+ + L +P Q ++ T G L KV Sbjct: 60 PHGASLYLPMEGLNCYRHAIAPLLFGADHPVL-----KQQRVATIQTLGGSGAL-KVGAD 113 Query: 128 IIN---PGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAK 184 + P V + +P + + G + + D+L+ K A Sbjct: 114 FLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLQAG 173 Query: 185 NPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY----YFLQFNK 240 + + P +NPTG LT+++ + E+ + + + D Y ++ + Sbjct: 174 S-------IVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDA 226 Query: 241 FRVPTFLSMDVDGRVIRADSFSKIISS-GLRIG---FLTGPKPLIERVILHIQVST---- 292 + + S + + ++SFSKI S G R+G + RV+ ++ + Sbjct: 227 YAIRAIASAGLP--ALVSNSFSKIFSLYGERVGGLSVMCEDAEAAGRVLGQLKATVRRNY 284 Query: 293 LHPSTFNQLMISQLLHEWGEEG-FMAHVDRVIDFYSNQKDAILAAADKWLTGL-AEWHVP 350 P F +++ +L++ + ++ V+ + + ++ + ++ + Sbjct: 285 SSPPNFGAQVVAAVLNDEALKASWLKEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLN 344 Query: 351 AAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA 405 GMF + + ++ + GV ++ V + R + + A Sbjct: 345 QRGMFSYTGLSAAQ-----VDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFA 394 >3G0T-A nrPDB Length = 437 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 77/412 (18%), Positives = 124/412 (30%), Gaps = 69/412 (16%) Query: 39 GLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPP 98 GLP P + E +I Y G+PEL + Sbjct: 55 GLPAPQIGIETEIQKLREGVASI------------YPNLDGLPELKQEASRFAK------ 96 Query: 99 TIHYPPSQGQMDLCVTSGSQQGLCKVFEMI----INPGDNVLLDEPAYSGTLQSLHPLGC 154 + T GS QG F + N L +P ++ LG Sbjct: 97 -LFVNIDIPARACVPTVGSMQGCFVSFLVANRTHKNREYGTLFIDPGFNLNKLQCRILGQ 155 Query: 155 NIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKK 214 + E + LR+ L + N NNPT +T E + Sbjct: 156 KFESFDLFE--YRGEKLREKLESYLQTGQFCS--------IIYSNPNNPTWQCMTDEELR 205 Query: 215 EIYELARKYDFLIIEDDPYYFLQF-NKFRVPTFLSMDVD-----GRVIRADSFSKIIS-S 267 I ELA K+D ++IED Y+ + F + P I A S SK S + Sbjct: 206 IIGELATKHDVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANYTDNYILALSSSKAFSYA 265 Query: 268 GLRIGFLTGPKPLIER------------------VILHIQVSTLHPSTFNQLMISQLLHE 309 G RIG L L ER + + + Q ++ +L Sbjct: 266 GQRIGVLMISGKLYEREYPDLEESFGRLRFGEALSSSALYALSSGATHSAQWGMAAMLKA 325 Query: 310 WGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLA---EWHVPAA-GMFLWIKVKGIND 365 + + + Y + + + + + P A G + + KG++ Sbjct: 326 CNDGEYNFRDSVI--EYGRKARIMKKMFLDNGFNIVYDKDGNEPLADGFYFTVGYKGMDS 383 Query: 366 VKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVL 417 K + EK V+ G+ + S + +R S Q + L Sbjct: 384 SK--LIEKFVRYGMCAI---TLKTTGSKRNEAMRICTSLLPESQFPDLEKRL 430 >3HDO-A nrPDB Length = 360 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 54/391 (13%), Positives = 110/391 (28%), Gaps = 47/391 (12%) Query: 31 KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQL 90 +++ S+ G +P + + N E++K L+ G L + Sbjct: 8 QNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDG-AALRIYPSAS 66 Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH 150 KL Y + + +GS + L + G+ + P+YS Sbjct: 67 SQKLREVAGELYGFDPSW--IIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAE 124 Query: 151 PLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS 210 G + R + K ++ + N P G S Sbjct: 125 VQGARVRTFGLTGDF-----------RIAGFPERYEGK-----VFFLTTPNAPLGPSFPL 168 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGL 269 E E+ +++ D+ Y + V+ + SK S +G+ Sbjct: 169 EYIDELARRCAG---MLVLDETYAEF----AESNALELVRRHENVVVTRTLSKSYSLAGM 221 Query: 270 RIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQ 329 RIG +I + L Q L + A++ Sbjct: 222 RIGLAIARPEVIAALDKIRDHYNL--DRLAQAACVAALRD------QAYLSECCRRIRET 273 Query: 330 KDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYV 389 ++ + P+ G +L+ + + + + VL+ + Sbjct: 274 REWFTTELRSIGYDVI----PSQGNYLFATPPDRD--GKRVYDGLYARKVLV----RHFS 323 Query: 390 DSSAPSPYLRASF-SSASPEQMDVAFQVLAQ 419 D +R S + EQ A + + + Sbjct: 324 DPLLAHG-MRISIGTREEMEQTLAALKEIGE 353 >3GET-A nrPDB Length = 365 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 56/345 (16%), Positives = 106/345 (30%), Gaps = 46/345 (13%) Query: 1 MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT 60 M + F+ S I + G K +I LA N PF T K Sbjct: 2 MKFNEFLNNLSNYEPGKDIEVIAK--EYGVKEVIKLA-----SNENPFGTPP------KA 48 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 I+ + +A Y P + EL S L Q ++ + +GS Q Sbjct: 49 IECLRQNANKAHLY-PDDSMIELKSTLAQKYK-------------VQNENIIIGAGSDQV 94 Query: 121 LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP 180 + +N + L ++ G S + +L + ++ Sbjct: 95 IEFAIHSKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQS-----ITHNLDEFKKLYET 149 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQF-- 238 + L + NNP G L + E + + D L++ D Y Sbjct: 150 HKDEIK-------LIFLCLPNNPLGECLDASEATEFIKGVNE-DCLVVIDAAYNEFASFK 201 Query: 239 NKFRVPTFLSM-DVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPS 296 + + + V+ +FSK+ GLRIG+ +I + + Sbjct: 202 DSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIANANIISAFYKLRAPFNVS-N 260 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSN-QKDAILAAADKW 340 + ++ + + E + + ++ Y K + D + Sbjct: 261 LALKAAVAAMDDDEFTEKTLENNFSQMELYKEFAKKHNIKIIDSY 305 >3RQ1-A nrPDB Length = 418 Score = 83.7 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 56/375 (14%), Positives = 119/375 (31%), Gaps = 56/375 (14%) Query: 72 LQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP 131 + Y+P AGIP+ L ++ P + T+G G+ + P Sbjct: 74 VGYAPIAGIPDFLCAAEKECFGNFRPEG--------HIRSIATAGGTGGIHHLIHNYTEP 125 Query: 132 GDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP 191 GD VL + + G ++ + + + ++ + K T Sbjct: 126 GDEVLTADWYWGAYRVICSDTGRTLVTYSLFDEHNNFNH-----EAFQNRVNELAAKQTN 180 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELAR------KYDFLIIEDDPYYFLQFNKFR--- 242 + GNNPTG S+ + I + + + +I D Y L ++ + Sbjct: 181 VVVIFNTPGNNPTGYSIEDKDWDSILNFLKDLVAIGRNNVIIGIDVAY--LDYSGEKDEV 238 Query: 243 ---VPTFLSMDVDGRVIRADSFSKII-SSGLRIGFLTG---PKPLIERVILHIQVSTLHP 295 F + + S SK G R+G + G + + + + ++ Sbjct: 239 RAFFNKFSHLPKEILTCVCYSLSKGFTMYGQRVGAMIGISDDEEIADEFFEVNKSTSRAT 298 Query: 296 -STFNQLMISQLLHEWGEEGFMAHVDRVID-FYSNQKDAILAAADKWLTGLAEWHVP-AA 352 S + + + + + + + +Y +D + + +P Sbjct: 299 WSNICRPAMRTMANIVADPAKFKEYEAERNCYYQLIRDRA-DIFKQEAAQVGLPMLPYRG 357 Query: 353 GMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSAS------ 406 G F+ I D I E+ K + ++ A + +R + Sbjct: 358 GFFITI----PTDSANAICEELKKEHIYVI----------ALANGIRIAACGIPKCQMTG 403 Query: 407 -PEQMDVAFQVLAQL 420 E++ A + L +L Sbjct: 404 LAEKIYNAMKSLGKL 418 >3FFH-A nrPDB Length = 363 Score = 82.2 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 79/204 (38%), Gaps = 19/204 (9%) Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIV 167 + +L T+G + + + ++++ N ++ P + Q+ G + + + G Sbjct: 84 EEELIFTAGVDELIELLTRVLLDTTTNTVMATPTFVQYRQNALIEGAEVREIPLLQDGE- 142 Query: 168 PDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLI 227 L +L+ + + + N NNPTGN + + + D L+ Sbjct: 143 -HDLEGMLNAIDEKT----------TIVWICNPNNPTGNYIELADIQAFLDR-VPSDVLV 190 Query: 228 IEDDPY-YFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVI 285 + D+ Y ++ + + +I +FSKI + R+G+ K +I ++ Sbjct: 191 VLDEAYIEYVTPQPEKHEKLV--RTYKNLIITRTFSKIYGLASARVGYGIADKEIIRQLN 248 Query: 286 LHIQVSTLHPSTFNQLMISQLLHE 309 + + ++ Q + + + + Sbjct: 249 IVR--PPFNTTSIGQKLAIEAIKD 270 >4RAE-A nrPDB Length = 394 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 57/389 (14%), Positives = 123/389 (31%), Gaps = 48/389 (12%) Query: 42 NPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIH 101 N N P A++ ++ E +Y P L L L I Sbjct: 40 NENPHPPTRALVD----DVVRSVREAAIDLHRY-PDRDAVALR---ADLAGYLTAQTGIQ 91 Query: 102 YPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV-A 160 ++ +GS + L ++ + PG + + P+YS I Sbjct: 92 LGVE----NIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASR 147 Query: 161 SDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA 220 +++ G+ D + KP+ + + + NNP+G S++ ++ ++A Sbjct: 148 ANDFGLDVDVAVAAVVDRKPD------------VVFIASPNNPSGQSVSLPDLCKLLDVA 195 Query: 221 RKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKP 279 I+ D+ Y F+ L + +++ + SK + +G R+G+L Sbjct: 196 --PGIAIV-DEAYGE--FSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGRLGYLIATPA 250 Query: 280 LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADK 339 +I+ ++L H S+ Q L + + +++ + + + Sbjct: 251 VIDAMLLVR--LPYHLSSVTQAAARAALRHSDD------TLSSVAALIAERERVTTSLND 302 Query: 340 WLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP--- 396 A L+ + E + + + +PG A Sbjct: 303 MG---FRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAF 359 Query: 397 ---YLRASFSSASPEQMDVAFQVLAQLIK 422 R + + V LA ++ Sbjct: 360 LRASARIATDLVPVTRSPVGAPKLAAALE 388 >6C3C-A nrPDB Length = 413 Score = 81.0 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 98/303 (32%), Gaps = 38/303 (12%) Query: 135 VLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFL 194 V L EP + L + + + + D + L R DA Sbjct: 132 VTLIEPCFDNLYDVLANMDVPLYPID-ESVFYDVDRIYPELERRVRTDA----------- 179 Query: 195 YTVPNGNNPTGNSL---TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV 251 + + NNPTG SL + +E+ + +D L++ D + + P D+ Sbjct: 180 LFLVDPNNPTGFSLLRHGRKGFEEVVRFCKDHDKLLLIDFCFASFTLFE---PELARFDM 236 Query: 252 DG-------RVIRADSFSKII-SSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMI 303 R + + K + +T + E V L+ S F + Sbjct: 237 YELLENSGVRYLAIEDTGKTWPVQDAKCALITASDDIWETVYNLHTSVLLNVSPF----V 292 Query: 304 SQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE--WHVPAAGMFLWIKVK 361 +L ++ + + V + + ++ D + E V A W +V Sbjct: 293 LNMLTQYVRDSAADRLASVREVLTRNRECARKTLDGSILEYQEPVVKVSVA----WFRVD 348 Query: 362 GINDVKELIEEKAVKMGVLMLPGNAFY-VDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 + GV +LPG FY + S Y+R + + PE A + Q+ Sbjct: 349 HPELTATDVHRLLSADGVYVLPGRYFYWSEPSKGDAYVRMALAR-EPEMFADAMALTRQV 407 Query: 421 IKE 423 + Sbjct: 408 LDR 410 >1LC8-A nrPDB Length = 364 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 100/314 (31%), Gaps = 43/314 (13%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDS 170 + +G + + V + ++ P ++ ++L GC I + E+ Sbjct: 79 ILAGNGETESIFTVASGLKPR--RAMIVTPGFAEYGRALAQSGCEIRRWSLREA------ 130 Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 W+ DA + NNPTG + I + + + +I D Sbjct: 131 -----DGWQLTDAILEALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINLILD 185 Query: 231 DPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQ 289 + + + F ++ + + S +K + GLR+G+L + + Sbjct: 186 EAF--IDFIPHETGFIPALKDNPHIWVLRSLTKFYAIPGLRLGYLVNSDD--AAMARMRR 241 Query: 290 VSTL-HPSTFNQLMISQLLHE--WGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE 346 + L L + W + + + FY L Sbjct: 242 QQMPWSVNALAALAGEVALQDSAWQQATWHWLREEGARFYQALCQLPLLTVY-------- 293 Query: 347 WHVPAAGMFLWIKV--KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASF-S 403 P +L ++ + I+ + L+ ++ + PG S Y R + S Sbjct: 294 ---PGRANYLLLRCEREDIDLQRRLLTQRILIRSCANYPGLD--------SRYYRVAIRS 342 Query: 404 SASPEQMDVAFQVL 417 +A E++ A + + Sbjct: 343 AAQNERLLAALRNV 356 >4WBT-A nrPDB Length = 376 Score = 77.9 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 52/362 (14%), Positives = 120/362 (33%), Gaps = 51/362 (14%) Query: 64 GEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCK 123 + +Y+ +L L + ++ + G L + Sbjct: 58 IRQAAGDTWKYADPENH-DLKQALARHLGT-------------SPANIAIGEGIDGLLGQ 103 Query: 124 VFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDA 183 + +++ G V+ Y + G ++ V + + L + R Sbjct: 104 IVRLVVEAGAPVVTSLGGYPTFNYHVAGHGGRLVTVPYADDREDLEGLLAAVGRENAP-- 161 Query: 184 KNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRV 243 L + N +NP G+ +ER + + L++ D+ Y + + Sbjct: 162 ----------LVYLANPDNPMGSWWPAERVVAFAQALPETTLLVL-DEAYCE-TAPRDAL 209 Query: 244 PTFLSMDVDGRVIRADSFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLM 302 P S+ VIRA +FSK +G RIG+ + +++ Sbjct: 210 PPIESLIDKPNVIRARTFSKAYGLAGARIGYTLSTPGTAQAFDKIRNHF-----GMSRIG 264 Query: 303 ISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV-K 361 ++ + ++ ++ V I + + +P+A F+ + K Sbjct: 265 VAAAIAALADQDYLKEVTLKIANSRQR-------IGRIAADSGLAPLPSATNFVAVDCGK 317 Query: 362 GINDVKELIEEKAVKMGVLM-LPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL 420 + + +++ G+ + +PG A + +R S +A +MD+ L ++ Sbjct: 318 DASYARAIVDRLMSDHGIFIRMPGVA------PLNRCIRIS--TAPDAEMDLLAAALPEV 369 Query: 421 IK 422 I+ Sbjct: 370 IR 371 >3FTB-A nrPDB Length = 361 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 54/352 (15%), Positives = 127/352 (36%), Gaps = 45/352 (12%) Query: 45 MFPFKTAVITVENGKTIQFGEEMMKRALQYSPSA---GIP-ELLSWLKQLQIKLHNPPTI 100 FK + + G G + L YS + GIP L+ + + L P + Sbjct: 2 YQKFKGGDLMIHGGDIYTEGVFKGRELLDYSSNINPLGIPKSFLNNIDEGIKNLGVYPDV 61 Query: 101 HYPPSQGQMD---------LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP 151 +Y ++ + + +G+ + + + + +L+ P+Y+ + Sbjct: 62 NYRRLNKSIENYLKLKDIGIVLGNGASEIIELSISLF----EKILIIVPSYAEYEINAKK 117 Query: 152 LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE 211 G +++ DE+ + DI+S+ D+ + N NNP G + E Sbjct: 118 HGVSVVFSYLDENMCI--DYEDIISKIDDVDS-----------VIIGNPNNPNGGLINKE 164 Query: 212 RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFL-SMDVDGRVIRADSFSKIIS-SGL 269 + + +LA + II D+ + ++F +F+ + + + +K + G+ Sbjct: 165 KFIHVLKLAEEKKKTIIIDEAF--IEFTGDPSSSFVGEIKNYSCLFIIRAMTKFFAMPGI 222 Query: 270 RIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQ 329 R G+ I I Q + + F ++ L + +++ + + + Sbjct: 223 RFGYGITNNKEIAAKIKAKQNP-WNINCFAEMAAINCLKDTN------YIEESLLWIKKE 275 Query: 330 KDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLM 381 + + +K + P A L + N E + + +K +++ Sbjct: 276 RKRFIEELNKIGF-IKRVFSPHANFVLC---RLENISGEKLYDSLLKEDIVI 323 >5DJ3-A nrPDB Length = 376 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 102/312 (32%), Gaps = 36/312 (11%) Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 S + L + + D V L P + L G +++ V D Sbjct: 93 SMEILARSLSASV---DRVALVHPTFDNIADLLRGNGLDLVPVEEDALH----------- 138 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 + + + V NNPTG L ER + + E ++ ++ D + Sbjct: 139 ----GADLSAELLSSVGCVFVTTPNNPTGRVLAEERLRRLAEQCAEHGTVLALDTSFRGF 194 Query: 237 ----QFNKFRVPTFLSMDVDGRVIRADSFSKIISS-GLRIGFLTGPKPLIERVILHIQVS 291 ++ + V + R + + K+ + L+ G L + + V Sbjct: 195 DAAAHYDHYAVLQ----EAGCRWVVIEDTGKLWPTLDLKAGLLVFSEDIGLPVEKIYSDI 250 Query: 292 TLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPA 351 L S +I + + + G ++ + + + A + P Sbjct: 251 LLGVSPLILALIREFSRDAADGGLADLHAFIL----HNRSVVRRALAG--VEGVSFPDPE 304 Query: 352 AGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAF-YVDSSAPSPYLRASFSSASPEQM 410 + + E+ EE + V LP F + + S +R + S ++ E + Sbjct: 305 SRSSVERVAFAGRTGTEVWEE-LQRHHVFALPCRQFHWAEPSDGDHMVRIALSRST-EPL 362 Query: 411 DVAFQVLAQLIK 422 + + QVL +++ Sbjct: 363 EKSVQVLRTVLE 374 >4RKC-A nrPDB Length = 398 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 60/385 (15%), Positives = 124/385 (32%), Gaps = 41/385 (10%) Query: 24 DILSRGPKSMISLAGGL--PNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIP 81 + ++L G+ + P V E Y P AG+P Sbjct: 19 KFAADNNPDKVNLGIGIYYDESGVMPVLDCVKIAEQRIADPISPRP------YLPMAGLP 72 Query: 82 ELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN---PGDNVLLD 138 ++L P G + T G L KV I+ P + Sbjct: 73 GHRKGCQELLFGKDAPVLKD-----GLVATIATIGGSGAL-KVGAEFIHEWFPQSKCYVS 126 Query: 139 EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVP 198 +P + + + ++ +++ A N L P Sbjct: 127 DPTWGNHIAIFEGCDIEVGKYPYYDTATGGIKFDEMI-------AFFETLNKDDVLLLHP 179 Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQ--FNKFRVPTFLSMDVDGRVI 256 +NPTG LT E+ + + ++ + + D Y + ++D+ + Sbjct: 180 CCHNPTGVDLTREQWDTVLNVIQERELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLF 239 Query: 257 RADSFSKIISS-GLRIG---FLTGPKPLIERV-----ILHIQVSTLHPSTFNQLMISQLL 307 ++SFSK +S G R+G + ERV ++ + PS +++ + Sbjct: 240 VSNSFSKNLSLYGERVGGLSVVCPTVDETERVFGQLNSTVRRIYSSPPSHGGRVVDIVMN 299 Query: 308 HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGL-AEWHVPAAGMFLWIKVKGINDV 366 E ++ V + D + + + + + ++G ++ GMF + + Sbjct: 300 DAALHEQWVGEVYAMRDRIKSMRTKLKSVLEAKISGRNFDYLTAQNGMFSFTGLTP---- 355 Query: 367 KELIEEKAVKMGVLMLPGNAFYVDS 391 E +E + G+ M+ + V Sbjct: 356 -EQVERLQSEFGIYMISNSRMCVAG 379 >4WD2-A nrPDB Length = 408 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 53/359 (14%), Positives = 122/359 (33%), Gaps = 33/359 (9%) Query: 18 PIRTMTDILSRGPKSM-ISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSP 76 PI T+ + + P+ ++L+ G+ F + + + + + + Y P Sbjct: 20 PILTLNENFQKDPRDQKVNLSIGI----YFDAEGRIPVMGAVREAETALQRDSGPKPYLP 75 Query: 77 SAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN---PGD 133 G+ ++ L +P + G++ T G L KV + P Sbjct: 76 MVGLAAYRDAVQSLVFGADHPAR-----AAGRIATLQTLGGSGAL-KVGADFLKRYFPDS 129 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 V L +P++ G + + +L+ A++ Sbjct: 130 QVWLSDPSWENHRFIFERAGFTVNTYPYYDEATGGLKFDAMLAAIDALPARS-------I 182 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN-KFRVPTFLSMDVD 252 + +NPTG L + +++ ++ + L D Y + Sbjct: 183 VLLHACCHNPTGVDLDEGQWEKLIDVIEARELLPFVDMAYQGFGAGLDADAFAVRELARR 242 Query: 253 G-RVIRADSFSKIISS-GLRIGF-------LTGPKPLIERVILHIQVSTLHPSTFNQLMI 303 G + A+SFSK S G R+G + ++ ++ ++ + +P T+ ++ Sbjct: 243 GVPTLVANSFSKNFSLYGERVGGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVV 302 Query: 304 SQLL-HEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWH-VPAAGMFLWIKV 360 + +L + + + + + + +I ++G A V GMF + + Sbjct: 303 AAVLGTPALRKQWEEELSAMCRRIARMRQSIHDGLRDHVSGEALTRYVKQRGMFTYTGL 361 >3P1T-A nrPDB Length = 337 Score = 71.4 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 88/277 (31%), Gaps = 46/277 (16%) Query: 140 PAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN 199 P + G + G L+ D + + + + N Sbjct: 98 PGFDGYRARIAVSGLR--------------HFEIGLTDDLLLDPNDLAQVSRDDCVVLAN 143 Query: 200 GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD 259 +NPTG +L++ ++ + A K ++ D+ Y ++ FR + + Sbjct: 144 PSNPTGQALSAGELDQLRQRAGK----LLIDETYVD--YSSFRA---RGLAYGENELVFR 194 Query: 260 SFSKIIS-SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAH 318 SFSK +GLR+G L GP LI + + + L + + AH Sbjct: 195 SFSKSYGLAGLRLGALFGPSELIAAMKRKQWFCNVGTLDLHALEAA----LDNDRAREAH 250 Query: 319 VDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMG 378 + + + DA+ GL + F+ ++ + E+ +++ Sbjct: 251 IAKTLAQRRRVADAL--------RGLGYRVASSEANFVLVENAAGERTLRFLRERGIQVK 302 Query: 379 VLMLPGNAFYVDSSAPSPYLRASFSSASP-EQMDVAF 414 ++R S +++ A Sbjct: 303 DA---------GQFGLHHHIRISIGREEDNDRLLAAL 330 >4F5M-A nrPDB Length = 406 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 63/403 (15%), Positives = 129/403 (32%), Gaps = 50/403 (12%) Query: 16 PSPIRTMTDIL-SRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQY 74 PI + D+ + I+L G+ KT V+T E + Y Sbjct: 20 ADPILGLADLFRADERPGKINLGIGVYKDET--GKTPVLTSVKKAEQYLLENETTK--NY 75 Query: 75 SPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD- 133 GIPE ++L + Q T G L + + Sbjct: 76 LGIDGIPEFGRCTQELLFGKGSALINDKRARTAQ-----TPGGTGALRVAADFLAKNTSV 130 Query: 134 -NVLLDEPAYSGTLQSLHPLGCNIINVA---SDESGIVPDSLRDILSRWKPEDAKNPQKN 189 V + P++ + G + A ++ + D+L + L+ + D Sbjct: 131 KRVWVSNPSWPNHKSVFNSAGLEVREYAYYDAENHTLDFDALINSLNEAQAGD------- 183 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY----FLQFNKFRVPT 245 + +NPTG T E+ + + +L+ + +L + D Y L+ + + Sbjct: 184 ---VVLFHGCCHNPTGIDPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRA 240 Query: 246 FLSMDVDGRVIRADSFSKIISSGL---RIG---FLTGPKPLIERVILHIQVST----LHP 295 F +M + +I A S+SK GL R+G + ++R ++ + +P Sbjct: 241 FAAMHKE--LIVASSYSKNF--GLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSNP 296 Query: 296 STFNQLMISQLLHEWGEEG-FMAHVDRVIDFYSNQKDAILAAADKWLTGL-AEWHVPAAG 353 +++ +L + + + + + + + + G Sbjct: 297 PAHGASVVATILSNDALRAIWEQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNG 356 Query: 354 MFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP 396 MF + + KE + + GV + V P Sbjct: 357 MFSFSGL-----TKEQVLRLREEFGVYAVASGRVNVAGMTPDN 394 >3BWN-A nrPDB Length = 391 Score = 67.5 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 57/362 (15%), Positives = 119/362 (32%), Gaps = 75/362 (20%) Query: 81 PELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMI--INPGDNVLLD 138 PEL +K L + + + V +GS Q + + V + Sbjct: 71 PELEDAIKDLH-------GVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQPVSVV 123 Query: 139 --EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYT 196 P YS ++ +R + +W+ + +K ++ Sbjct: 124 AAAPFYSTYVEET-------------------TYVRSGMYKWEGDAWGFDKKGP--YIEL 162 Query: 197 VPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVI 256 V + NNP G ++ + + +I D YY+ + I Sbjct: 163 VTSPNNPDGTI-----RETVVNRPDDDEAKVIHDFAYYWPHYTPIT-------RRQDHDI 210 Query: 257 RADSFSKIIS-SGLRIGFL-TGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG 314 +FSKI +G RIG+ K + ++++ +I V+++ S +Q+ +++L+ E Sbjct: 211 MLFTFSKITGHAGSRIGWALVKDKEVAKKMVEYIIVNSIGVSKESQVRTAKILNVLKETC 270 Query: 315 FMAHVDRVIDFYSNQKDAI---LAAADKWLTGLAEWHVPA--AGM-------------FL 356 F+ ++ + + + + +P F Sbjct: 271 KSESESEN--FFKYGREMMKNRWEKLREVVKESDAFTLPKYPEAFCNYFGKSLESYPAFA 328 Query: 357 WIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQV 416 W+ K D L+ E + V+ G D ++R S + + +V + Sbjct: 329 WLGTKEETD---LVSELR-RHKVMSRAGERCGSD----KKHVRVS-MLSREDVFNVFLER 379 Query: 417 LA 418 LA Sbjct: 380 LA 381 >1AY8-A nrPDB Length = 394 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 103/334 (30%), Gaps = 40/334 (11%) Query: 22 MTDILSRGPKSMISLAGGL-PNPNMF-PFKTAVITVENGKTIQFGEEMMKRALQYSPSAG 79 M + + + I L G+ + P AV E + Y+ +G Sbjct: 17 MGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKT------YAGLSG 70 Query: 80 IPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEM--IINPGDNVLL 137 PE + +L + T G L + E+ + NP V + Sbjct: 71 EPEFQKAMGELI--------LGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFV 122 Query: 138 DEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTV 197 +P + + ++ +G + V + ++ A + Sbjct: 123 SDPTWPNHVSIMNFMG---LPVQTYRYF----DAETRGVDFEGMKADLAAAKKGDMVLLH 175 Query: 198 PNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL--QFNKFRVPTFLSMDVDGRV 255 +NPTG +LT ++ EI + K L + D Y + T L V Sbjct: 176 GCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEV 235 Query: 256 IRADSFSKIISSGL---RIGFL------TGPKPLIE-RVILHIQVSTLHPSTFNQLMISQ 305 + A S SK G+ R G L + L + + + + P ++S Sbjct: 236 LIAASCSKNF--GIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVST 293 Query: 306 LLHE-WGEEGFMAHVDRVIDFYSNQKDAILAAAD 338 +L +MA ++ V ++ + Sbjct: 294 VLTTPELRADWMAELEAVRSGMLRLREQLAGELR 327 >4PIW-A nrPDB Length = 396 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 102/326 (31%), Gaps = 50/326 (15%) Query: 111 LCVTSGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 + +T L ++ I PGD V++ + T + G I+ V + D Sbjct: 69 VLLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNID 128 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIE 229 T K VP G + I LA+K++ ++E Sbjct: 129 E------------TLIEAAITDKTRVIVPVHY--AGVAC---EMDTIMALAKKHNLFVVE 171 Query: 230 DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF--SKIISSGLRIG-FLTGPKPLIERVIL 286 D + K R + I SF +K ++G G L K LIER + Sbjct: 172 DAAQGVMSTYKGRALGTIGH------IGCFSFHETKNYTAGGEGGATLINDKALIERAEI 225 Query: 287 HIQ-----------------VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVI--DFYS 327 + + S + + L E + R+ Y Sbjct: 226 IREKGTNRSQFFRGQVDKYTWRDIGSSYLMSDLQAAYLWAQLEAADRINQQRLALWQNYY 285 Query: 328 NQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKE---LIEEKAVKMGVLMLPG 384 + + A L + + V A MF +IK++ I+D ++E + +P Sbjct: 286 DALAPLAKAGRIELPSIPDGCVQNAHMF-YIKLRDIDDRSALINFLKEAEIMAVFHYIPL 344 Query: 385 NAFYVDSSAPSPYLRASFSSASPEQM 410 + + +++ E++ Sbjct: 345 HGCPAGEHFGEFHGEDRYTTKESERL 370 >3TQX-A nrPDB Length = 399 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 55/358 (15%), Positives = 118/358 (32%), Gaps = 41/358 (11%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPG 132 QY G+ + +H G D + S +FE ++ P Sbjct: 72 QYG--FGMASVRFI--CGTQTIHKELEKDISEFLGTDDTILYSSCFDANGGLFETLLGPE 127 Query: 133 DNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPK 192 D ++ DE ++ + + ++ G L L + A+ T Sbjct: 128 DAIISDELNHASIIDGIRLCKAQRYRYKNNAMG----DLEAKLKEADEKGARFKLIATDG 183 Query: 193 FLYTVPNGNNPTGNSLTSE----RKKEIYELARKYDFLIIEDD--PYYFLQFNKFRVPTF 246 + + K I +LA KY+ L++ DD F+ N P + Sbjct: 184 --------------VFSMDGIIADLKSICDLADKYNALVMVDDSHAVGFIGENGRGTPEY 229 Query: 247 LSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQL 306 + ++ + K + G G+ +G K +IE + L +T ++++ Sbjct: 230 CGVADRVDILT-GTLGKALG-GASGGYTSGHKEIIEWLRN-RSRPYLFSNTVAPVIVATS 286 Query: 307 LHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDV 366 L E ++ A +K L + P + + + Sbjct: 287 LK--VLELLKTEGPQLRKQLQENSRYFRAGMEKLGFQLVPGNHPI----IPVMLGDAQLA 340 Query: 367 KELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA-SPEQMDVAFQVLAQLIKE 423 + + + G+ ++ G ++ V + +R S+ + +Q+D A + Q+ K+ Sbjct: 341 TNMADHLLQE-GIYVV-GFSYPVVPMGKAR-IRVQMSAVHTQQQLDRAIEAFGQVGKK 395 >4W5K-A nrPDB Length = 396 Score = 61.4 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 46/336 (13%), Positives = 106/336 (31%), Gaps = 44/336 (13%) Query: 39 GLPNPNMFPFKTAVITVENGKT------------IQFGEEMMKRA-----LQYSPSAGIP 81 G P+P + + + K F E +K+A + Y+P GI Sbjct: 10 GKPDPILGLGQDFRMDPAKRKVNLSIGVYRDDADQPFVLECVKQATLGTNMDYAPVTGIA 69 Query: 82 ELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCK---VFEMIINPGDNVLLD 138 + ++L G++ C T G L + + + + Sbjct: 70 SFVEEAQKL-----CFGPTCAALRDGRIASCQTLGGTGALRIGGDLLNRFVANCNRIYGP 124 Query: 139 EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVP 198 + Y G + + + +L +L + + Sbjct: 125 DVGYPNHESIFAKAGMELTPYSYYDPATKGLNLAGMLECLDKAPEGS-------VILVHA 177 Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL---QFNKFRVPTFLSMDVDGRV 255 +NPTG T + +++ ++ ++ + + D Y Q + +D+ + Sbjct: 178 CAHNPTGVDPTHDDWRQVCDVIKRRNHIPFVDMAYQGFATGQLDYDAFVPRHLVDMVPNL 237 Query: 256 IRADSFSKIISS-GLRIG---FLTGPKP----LIERVILHIQVSTLHPSTFNQLMISQLL 307 I A SFS G R G T L+ ++ L I+ +P + ++S +L Sbjct: 238 IVAQSFSANFGLYGHRCGALHISTASAEEAKRLVSQLALLIRPMYSNPPLYGAWVVSSIL 297 Query: 308 HEWGEEG-FMAHVDRVIDFYSNQKDAILAAADKWLT 342 + + + ++ + + +++ + Sbjct: 298 KDPQLTALWKKELKQMSSRIAEVRKRLVSELKACGS 333 >6BLG-A nrPDB Length = 379 Score = 61.0 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 92/327 (28%), Gaps = 54/327 (16%) Query: 112 CVTSGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDS 170 +T L ++ I PGD V++ + T + G I+ V + D Sbjct: 53 LLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDIRRDTMNIDE 112 Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 T K VP G + I +A KY+ ++ED Sbjct: 113 ------------TLIEAAITDKTRAIVPVHY--AGVAC---EMDTIMAIADKYNLFVVED 155 Query: 231 DPYYFLQFNKFRVPTFLSMDVDGRVIRADSF--SKIISSGLRIGFLTGP-------KPLI 281 + K R + I SF +K ++G G +I Sbjct: 156 AAQGVMSTYKGRALGTIGH------IGCFSFHETKNYTAGGEGGATLINDRTLVERAEII 209 Query: 282 ER-----------VILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 ++ + S + + L E + + + N Sbjct: 210 REKGTNRSQFFRGLVDKYTWRDIGSSYLMSDLQAAYLW-AQLEAAERINQQRLALWQNYY 268 Query: 331 DAILAAADKWLTGLAEWHVPAA--GMFLWIKVKGINDVKELIEEKAVKMGVLM---LPGN 385 DA+L A L +IK++ I D LI + + +P + Sbjct: 269 DALLPLARAGRIELPTVPADCGQNAHMFYIKLRDIEDRSRLIAWLKEAEILAVFHYIPLH 328 Query: 386 AFYVDSSAPSPYLRAS--FSSASPEQM 410 + R +++ E++ Sbjct: 329 SCPAGEQFGE--FRGEDRYTTQESERL 353 >1FC4-A nrPDB Length = 401 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 59/361 (16%), Positives = 121/361 (33%), Gaps = 34/361 (9%) Query: 67 MMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFE 126 +A S G+ + H G D + S +FE Sbjct: 66 AAAKAGMDSHGFGMASVRFI--CGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFE 123 Query: 127 MIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNP 186 ++ D ++ D ++ + + A+++ L L + A++ Sbjct: 124 TLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANND----MQELEARLKEAREAGARHV 179 Query: 187 QKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTF 246 T N K + +LA KYD L++ DD + + + Sbjct: 180 LIATDGVFSMDGVIAN----------LKGVCDLADKYDALVMVDDSHAVGFVGENGRGSH 229 Query: 247 LSMDVDGRV-IRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQ 305 DV GRV I + K + G G+ K ++E + L ++ +++ Sbjct: 230 EYCDVMGRVDIITGTLGKALG-GASGGYTAARKEVVEWLRQ-RSRPYLFSNSLAPAIVAA 287 Query: 306 LLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGL--AEWHVPAAGMFLWIKVKGI 363 + V +++ S +D + A A ++ + A + + A + + G Sbjct: 288 SIK----------VLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGD 337 Query: 364 NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSA-SPEQMDVAFQVLAQLIK 422 V + + K G+ + FY +R S+A +PEQ+ A + ++ K Sbjct: 338 AVVAQKFARELQKEGIYVT--GFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGK 395 Query: 423 E 423 + Sbjct: 396 Q 396 >4K2M-A nrPDB Length = 443 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 42/122 (34%), Gaps = 20/122 (16%) Query: 111 LCVTSGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 + TS + + +NPGD V++ ++S T ++ G I V + D Sbjct: 121 VIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGGVPIYVDINPQTFCID 180 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE-RKKEIYELARKYDFLII 228 K + TP + +P + I ++A +Y +I Sbjct: 181 ------------PDKIEEAITPYTKFILPVH------LYGKHSDMQHIRQIANRYKLKVI 222 Query: 229 ED 230 ED Sbjct: 223 ED 224 >3DR4-A nrPDB Length = 391 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 36/231 (15%), Positives = 70/231 (30%), Gaps = 44/231 (19%) Query: 117 SQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 L + I PGD V++ Y + S+ G + V +D Sbjct: 80 GTTALHLALVAMGIGPGDEVIVPSLTYIASANSVTYCGATPVLVDNDP------------ 127 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY- 234 + + AK TP+ +P G + I E+AR+++ L+IED Sbjct: 128 RTFNLDAAKLEALITPRTKAIMPVHL--YGQICDMD---PILEVARRHNLLVIEDAAEAV 182 Query: 235 FLQFNKFRVPTF---LSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVS 291 + + + + G I G +T + + ++ Sbjct: 183 GATYRGKKSGSLGDCATFSFFGNAIITTGEG---------GMITTNDDDLAAKMRLLRGQ 233 Query: 292 TLHPS-------------TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQ 329 + P+ N L + +A +RV+ +Y + Sbjct: 234 GMDPNRRYWFPIVGFNYRMTNIQAAIGLAQLERVDEHLAARERVVGWYEQK 284 >4EFF-A nrPDB Length = 420 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 52/411 (12%), Positives = 125/411 (30%), Gaps = 58/411 (14%) Query: 31 KSMISLAGGLPNPN--MFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLK 88 + ++L G+ P AV E + Y P GI + ++ Sbjct: 49 PTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVEAGLPR------GYLPIDGIAAYDASVQ 102 Query: 89 QLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKV--FEMIINPGDNVLLDEPAYSGTL 146 +L + +P Q G L F +NP V + +P++ Sbjct: 103 KLLLGDDSPLIAAGRVVTAQ-----ALGGTGALKIGADFLRTLNPKAKVAISDPSWENHR 157 Query: 147 QSLHPLGCNIINVA---SDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNP 203 G ++ + +G+ D + L+ ++P + +NP Sbjct: 158 ALFDMAGFEVVAYPYYDAKTNGVNFDGMLAALNGYEPGT----------IVVLHACCHNP 207 Query: 204 TGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN---KFRVPTFLSMDVDGRVIRADS 260 TG L + ++ E+ + + D Y + + + + Sbjct: 208 TGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNVFVSSSF 267 Query: 261 FSKIISSGLRIG---FLTGPKP----LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEE 313 G R+G +T K ++ ++ I+ + +P T +++ +L Sbjct: 268 SKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVLASPELR 327 Query: 314 G-FMAHVDRVIDFYSNQKDAILAAADKWLTGL-AEWHVPAAGMFLWIKVKGINDVKELIE 371 ++ + + D ++ ++ + GMF + + ++ Sbjct: 328 ASWVQELGEMRDRIRAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGL-----TSAQVD 382 Query: 372 EKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 + G+ + R ++ + +DV +A ++K Sbjct: 383 RLREEFGIYAV-------------STGRICVAALNTRNLDVVANAIAAVLK 420 >2OGE-A nrPDB Length = 399 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 82/269 (30%), Gaps = 47/269 (17%) Query: 119 QGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSR 177 L + I PGD V++ Y + ++ G + V E D L Sbjct: 89 DALQLALRGLGIGPGDEVIVPSHTYIASWLAVSATGATPVPVEPHEDHPTLDPL------ 142 Query: 178 WKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS-ERKKEIYELARKYDFLIIEDDPYYF- 235 + TP+ +P + ELA ++ I+ED Sbjct: 143 ------LVEKAITPRTRALLPVH------LYGHPADMDALRELADRHGLHIVEDAAQAHG 190 Query: 236 LQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGF-------LTGPKPLIERVILHI 288 ++ R+ G + A SF G +G +TG L ER+ + Sbjct: 191 ARYRGRRI-------GAGSSVAAFSF----YPGKNLGCFGDGGAVVTGDPELAERLRMLR 239 Query: 289 QVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWH 348 + + + L E + + +D ++ ++ A+ A L GL Sbjct: 240 NYGSRQKYSHETKGTNSRLDEM-QAAVLRIRLAHLDSWNGRRSALAAEYLSGLAGLPGIG 298 Query: 349 VPAAGMFLWIKVKGINDVKELIEEKAVKM 377 +P + + V L + + Sbjct: 299 LP-------VTAPDTDPVWHLFTVRTERR 320 >3PD6-B nrPDB Length = 401 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 58/379 (15%), Positives = 121/379 (31%), Gaps = 38/379 (10%) Query: 16 PSPIRTMTDILSRGPKSM-ISLAGGL-PNPNMFPFKTAVITVENGKTIQFGEEMMKRALQ 73 P PI +T+ R S ++L G + N P+ + Q + + + + Sbjct: 12 PDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSV---RKAEAQIAAKNLDK--E 66 Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCV-TSGSQQGL---CKVFEMII 129 Y P G+ E +L + + + + V T L + Sbjct: 67 YLPIGGLAEFCKASAELAL------GENNEVLKSGRFVTVQTISGTGALRVGASFLQRFF 120 Query: 130 NPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKN 189 +V L +P++ G + + L ++ Sbjct: 121 KFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQS---- 176 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLS- 248 L +NPTG E+ KEI + +K + D Y + Sbjct: 177 ---VLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVR 233 Query: 249 --MDVDGRVIRADSFSK-IISSGLRIG---FLTGPKPLIERVILHIQVST----LHPSTF 298 ++ V S++K + G R+G + +RV +++ +P Sbjct: 234 HFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLN 293 Query: 299 NQLMISQLLHEWG-EEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAA-GMFL 356 + + +L + ++ V + D + + +++ K + H+ GMF Sbjct: 294 GARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFC 353 Query: 357 WIKVKGINDVKELIEEKAV 375 + +K V+ L +E +V Sbjct: 354 FTGLKPEQ-VERLTKEFSV 371 >3NYS-A nrPDB Length = 367 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 30/178 (16%), Positives = 49/178 (27%), Gaps = 35/178 (19%) Query: 57 NGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 I G + + R QY + EL L + + Sbjct: 14 IKDKIDAGIQRVLRHGQYILGPEVTELEDRLADFVGAKYCISCAN--------------- 58 Query: 117 SQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 L V + + PGD V+ Y T +++ LG + V D Sbjct: 59 GTDALQIVQMALGVGPGDEVITPGFTYVATAETVALLGAKPVYVDIDP------------ 106 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS-ERKKEIYELARKYDFLIIEDDP 232 + + TP+ +P + I +A KY +IED Sbjct: 107 RTYNLDPQLLEAAITPRTKAIIPV------SLYGQCADFDAINAIASKYGIPVIEDAA 158 >1M6S-A nrPDB Length = 347 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 40/281 (14%), Positives = 81/281 (28%), Gaps = 29/281 (10%) Query: 59 KTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQ 118 K + + M +A G ++ L++L + + PS T G+Q Sbjct: 15 KPTEEMRKAMAQAEVGDDVYGEDPTINELERLAAETFGKEAALFVPSG-------TMGNQ 67 Query: 119 QGLCKVFEMIINPGDNVLLDEP---AYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 GD V+L+ + G V + PD +R + Sbjct: 68 ----VSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGVMPHPVPGKNGAMDPDDVRKAI 123 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGN-SLTSERKKEIYELARKYDFLIIEDDPYY 234 + L + N +N +G + E KEI +A+++ + D Sbjct: 124 RPRNIHFPRTS-------LIAIENTHNRSGGRVVPLENIKEICTIAKEHGINVHIDGA-R 175 Query: 235 FLQFNKFRVPTFLSMDVDGRVIRADSFSKII-SSGLRIG-FLTGPKPLIERVILHIQVST 292 + + SK + + +G + G + IER ++ Sbjct: 176 IFNASIASGVPVKEYAGYADSVMF-CLSKGLCAP---VGSVVVGDRDFIERARKARKMLG 231 Query: 293 LHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAI 333 L + ++ + F + + I Sbjct: 232 GGMRQAGVLAAAGIIALTKMVDRLKEDHENARFLALKLKEI 272 >1SFF-A nrPDB Length = 426 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 35/223 (15%), Positives = 80/223 (35%), Gaps = 23/223 (10%) Query: 209 TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG 268 + + + L ++ ++I D+ R T +M+ G +F+K I+ G Sbjct: 218 SPAFMQRLRALCDEHGIMLIADEVQSG----AGRTGTLFAMEQMGVAPDLTTFAKSIAGG 273 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSN 328 + +TG +++ V T + + ++L + +E + + + Sbjct: 274 FPLAGVTGRAEVMDAVAPGGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQKLK- 332 Query: 329 QKDAILAAADKWLTGLAEWHVPAAGMF---LWIKVKGINDVKELIEE---KAVKMGVLML 382 D +LA A+K + + M L+ +L E +A G+++L Sbjct: 333 --DGLLAIAEKH-PEIGDVRG-LGAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILL 388 Query: 383 PGNAFYVDSSAPSPYLR-ASFSSASPEQMDVAFQVLAQLIKES 424 +Y LR + Q+ ++++Q E+ Sbjct: 389 SCGPYY-------NVLRILVPLTIEDAQIRQGLEIISQCFDEA 424 >3II0-A nrPDB Length = 422 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 61/382 (15%), Positives = 123/382 (32%), Gaps = 66/382 (17%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDL--CVTSGSQQGL-----CKV- 124 +Y P G+ E S +L + P+ + + + G L Sbjct: 58 EYLPILGLAEFRSCASRLAL-------GDDSPALKEKRVGGVQSLGGTGALRIGADFLAR 110 Query: 125 -FEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV----ASDESGIVPDSLRDILSRWK 179 + N V + P + G I +++ G+ + L Sbjct: 111 WYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLE--- 167 Query: 180 PEDAKNPQKNTPKFLYTVPNG--NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYF-- 235 N P+F V + +NPTG T E+ K+I + + D Y Sbjct: 168 ---------NAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFA 218 Query: 236 ---LQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGL---RIG--FLTGPKP-----LIE 282 L+ + + + F+S + A SFSK GL R+G + G +P ++ Sbjct: 219 SGNLERDAWAIRYFVSEGFE--FFCAQSFSKNF--GLYNERVGNLTVVGKEPESILQVLS 274 Query: 283 RVILHIQVSTLHPSTFNQLMISQLLHE-WGEEGFMAHVDRVIDFYSNQKDAILAAADKWL 341 ++ ++++ +P +++ L E + +V + D + + A + Sbjct: 275 QMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALK 334 Query: 342 -TGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRA 400 G GMF + + +E + + +LP V Sbjct: 335 TPGTWNHITDQIGMFSFTGLNPKQ-----VEYLVNEKHIYLLPSGRINVSGLTTKN---L 386 Query: 401 SFSSASPEQMDVAFQVLAQLIK 422 + + S + A +A+ + Sbjct: 387 DYVATS---IHEAVTKIAENLY 405 >1MDZ-A nrPDB Length = 393 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 37/119 (31%), Gaps = 18/119 (15%) Query: 117 SQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 + G+ + I GD V+ + TL + LG N + V D ++ Sbjct: 63 ATAGMHIALMALGIGEGDEVITPSMTWVSTLNMIVLLGANPVMVDVDRDTLMV------- 115 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 TP+ +P G IY L +Y +IED + Sbjct: 116 -----TPEHIEAAITPQTKAIIPVHY--AGA---PADLDAIYALGERYGIPVIEDAAHA 164 >2CST-A nrPDB Length = 411 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 60/336 (17%), Positives = 113/336 (33%), Gaps = 62/336 (18%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMII--- 129 +Y P G+PE + ++ + +P +Q ++ G L ++ + Sbjct: 68 EYLPILGLPEFRANASRIALGDDSP-----AIAQKRVGSVQGLGGTGAL-RIGAEFLRRW 121 Query: 130 -----NPGDNVLLDEPAYSGTLQSLHPLGCNIINV----ASDESGIVPDSLRDILSRWKP 180 N V + P + G I + + G+ L D + + Sbjct: 122 YNGNNNTATPVYVSSPTWENHNSVFMDAGFKDIRTYRYWDAAKRGLDLQGLLDDMEKA-- 179 Query: 181 EDAKNPQKNTPKFLYTVPNG--NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYF--- 235 P+F + + +NPTG T + K+I + ++ D Y Sbjct: 180 ----------PEFSIFILHACAHNPTGTDPTPDEWKQIAAVMKRRCLFPFFDSAYQGFAS 229 Query: 236 --LQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGL---RIG---FLTGPKPLIERVILH 287 L + + V F+S + + A SFSK GL R+G + + ++RV+ Sbjct: 230 GSLDKDAWAVRYFVSEGFE--LFCAQSFSKNF--GLYNERVGNLSVVGKDEDNVQRVLSQ 285 Query: 288 IQ--VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLA 345 ++ V T + +Q + F D V D +L + + L Sbjct: 286 MEKIVRTTWSNPPSQGARIVATTLTSPQLFAEWKDNV----KTMADRVLLMRSELRSRLE 341 Query: 346 EWHVP--------AAGMFLWIKVKGINDVKELIEEK 373 P GMF + + V+ +I+EK Sbjct: 342 SLGTPGTWNHITDQIGMFSFTGLNPKQ-VEYMIKEK 376 >5I92-A nrPDB Length = 435 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 121/416 (29%), Gaps = 56/416 (13%) Query: 38 GGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNP 97 GG P V+ ++ + + + L +S + + L P Sbjct: 38 GGTPLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRRQLDHGLS-YGAP 96 Query: 98 PTIHYPPSQ-------GQMDLCVTSGSQQGLCKVFEMIINPG----DNVLLDEPAYSGTL 146 + + + + S + + G D+++ E Y G Sbjct: 97 TALEVEMADLVCSMVPSMEMVRMVSSGTEATMSAIR--LARGYTGRDSIIKFEGCYHGHS 154 Query: 147 QSLHP-LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQK------NTPKFLYTVPN 199 SL G + S VP + D + +K + P Sbjct: 155 DSLLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVEPV 214 Query: 200 GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD 259 N + + E ++ ++I D+ FRV + G Sbjct: 215 AGNMNCVPPAPGFLEGLREACDEHGVVLIFDEV-----MTGFRVALGGAQAYYGVTPDLS 269 Query: 260 SFSKIISSGLRIGFLTGPKPLIERVILH---IQVSTLHPSTFNQLMISQLLHEWGEEGFM 316 +F KII G+ +G G + +++++ Q TL + L GF Sbjct: 270 TFGKIIGGGMPVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISRPGFH 329 Query: 317 AHV----DRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMF----------LWIKVKG 362 + R++D + DA G+ A GMF + + Sbjct: 330 DELTAYTTRMLDGLQQRADA---------AGIPFVTTQAGGMFGLYFSGADAIVTFEDVM 380 Query: 363 INDVKEL--IEEKAVKMGVLMLPGNAFYVD-SSAPSPYLRASFSSASPEQMDVAFQ 415 +DV+ + GV + P +AF +S + + E+ A + Sbjct: 381 ASDVERFKRFFHLMLDGGVYLAP-SAFEAGFTSIAHGDKELEITLNAAEKAFAALK 435 >3UWC-A nrPDB Length = 374 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 52/386 (13%), Positives = 129/386 (33%), Gaps = 83/386 (21%) Query: 83 LLSWL--------KQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMI-INPGD 133 L ++ +L+ +H P + V +G L F+M+ I GD Sbjct: 25 LREFIKTADFTLGAELEKFEKRFAALHNAPHA----IGVGTG-TDALAMSFKMLNIGAGD 79 Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 V+ + ++ ++ G + V S+ ++ + K T K Sbjct: 80 EVITCANTFIASVGAIVQAGATPVLVDSENGYVI-------------DPEKIEAAITDKT 126 Query: 194 LYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED------------DPYYFLQFNKF 241 +P TGN + ++A+K++ I+ED + QF F Sbjct: 127 KAIMPVHY--TGNIAD---MPALAKIAKKHNLHIVEDACQTILGRINDKFVGSWGQFACF 181 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 + +++V + S + LR+ LI R + T + Sbjct: 182 SLHPLKNLNVWSDAGVIITHSDEYAEKLRL---YRNHGLINRDVCVEYGINCRMDTIQAV 238 Query: 302 MISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWH-VP---AAGMFLW 357 + ++L+++ ++ + ++ I D+ L+E+ VP ++ Sbjct: 239 IANRLMNQ-------------LETITEKRRGIAHLYDQSFVDLSEFIDVPVRREGVYHVF 285 Query: 358 ----IKVKGINDVKELIEEKAVKMGV------LMLPG--------NAFYVDSSAPSPYLR 399 ++VK + + + +++ +++ + + P F + + Sbjct: 286 HIYVLRVKYRDQLFQYLKDNGIEVKIHYPIAMHLQPAAKSLGYQQGDFPMAEKHGEAVIT 345 Query: 400 A-SFSSASPEQMDVAFQVLAQLIKES 424 + + E+++ + + + E Sbjct: 346 LPAHPYLTEEEINYIIKKVREFYLEK 371 >6EZL-A nrPDB Length = 404 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 62/437 (14%), Positives = 127/437 (29%), Gaps = 65/437 (14%) Query: 18 PIRTMTDILSRGPKSMIS----LAGGLPNPNMFPFKTAVITVENGKT-IQFGEEMMKRAL 72 IR + + ++ P I +A P P A E + + +R L Sbjct: 2 AIRCLWNNIAALPADPIFSASLVAKKAPEPKADLIIGAYRDAEGHPYPLNVVRKAEQRLL 61 Query: 73 Q------YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQ----GLC 122 + Y P +G + I Y S + ++ G + Sbjct: 62 EMNADKEYLPMSGYAPFIE----------ESLKIAYGDSVARENVVGIQGLSGTGSLSIG 111 Query: 123 KVFEM-IINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPE 181 F +++ V + +P + + +D + Sbjct: 112 ACFLARVLSRDTPVYISDPTWPNHYAVMAAAN------LTDLRKYRYYDNAKRCIDFDGL 165 Query: 182 DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN-- 239 + +NPTG T E+ +I E+ + + D Y Sbjct: 166 LEDLNGAPEGSIVILHACAHNPTGMDPTHEQWAKILEVFQARRLIPFFDSAYQGYATGSL 225 Query: 240 KFRVPTFLSMDVDG-RVIRADSFSKIISSGL---RIG---FLTGPK---PLIE-RVILHI 288 + G ++ A S+SK + GL R+G +T PLI+ ++ + Sbjct: 226 DNDAYSIRLFARQGMEMLLAQSYSKNM--GLYAERVGVCSIVTANPKKAPLIKSQLETIV 283 Query: 289 QVSTLHPSTFNQLMISQLLHE-WGEEGFMAHVDRVIDFYSNQKDAILAAADKWL-TGLAE 346 + P + +L + G+ + + + A+ + G E Sbjct: 284 RSQYSTPPAHGARVAYLVLSDPELRAGWEQELRVMSTRVLEMRQALYDGLKRLGTPGSWE 343 Query: 347 WHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSAS 406 + GMF ++ + EK ++ V +LP + + S Sbjct: 344 HIIQQVGMFSYLGLTKAQ------CEKLIERRVFVLPSGRANMAG----------LTKRS 387 Query: 407 PEQMDVAFQVLAQLIKE 423 E + + + + E Sbjct: 388 VELLVKGIDEVVRTVTE 404 >2C81-A nrPDB Length = 418 Score = 51.7 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 68/202 (33%), Gaps = 33/202 (16%) Query: 111 LCVTSGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 + TSGS L E + I GD V++ + T ++ + + V + D Sbjct: 61 VPTTSGST-ALMLALEALGIGEGDEVIVPSLTWIATATAVLNVNALPVFVDVEADTYCID 119 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIE 229 T K +P G + EI E+A++++ +IE Sbjct: 120 ------------PQLIKSAITDKTKAIIPVHLF--G---SMANMDEINEIAQEHNLFVIE 162 Query: 230 DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFS----KIISSGLRIGFLTG-PKPLIERV 284 D + + G + +FS K++++G G + L E + Sbjct: 163 DCA--------QSHGSVWNNQRAGTIGDIGAFSCQQGKVLTAGEG-GIIVTKNPRLFELI 213 Query: 285 ILHIQVSTLHPSTFNQLMISQL 306 S ++ ++LM + Sbjct: 214 QQLRADSRVYCDDSSELMHGDM 235 >4ADC-A nrPDB Length = 406 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 44/386 (11%), Positives = 113/386 (29%), Gaps = 47/386 (12%) Query: 58 GKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIK-LHNPPTIHYPPSQGQMDLCV--- 113 + I F + AL ++ PEL L + K H P + Sbjct: 39 KEYIDFAGGIAVNALGHA----HPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDAT 94 Query: 114 ----------TSGSQQGLCKVFEMIINP--GDN---VLLDEPAYSGTLQSLHPLGCNIIN 158 + + + K+ + G + ++ + A+ G G Sbjct: 95 FADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAY 154 Query: 159 VASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS-LTSERKKEIY 217 S + +P +R + +T + G G ++ + + Sbjct: 155 --SQDFAPLPADIRHAAYNDINSASALIDDSTCAVIVEPIQGE--GGVVPASNAFLQGLR 210 Query: 218 ELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGP 277 EL +++ L+I D+ + G + +K + G +G L Sbjct: 211 ELCNRHNALLIFDEVQTGVGRTGELYAYMH----YGVTPDLLTTAKALGGGFPVGALLAT 266 Query: 278 KPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAA 337 + + + +T + + ++L + V + D++ + + + Sbjct: 267 EECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN-TINHR 325 Query: 338 DKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPY 397 + + + + + K++ +E A ++++ G Sbjct: 326 YGLFSEVRGLGLLIGCV---LNADYAGQAKQISQEAAKAGVMVLIAGG----------NV 372 Query: 398 LRASFSS-ASPEQMDVAFQVLAQLIK 422 +R + + S E++ A + Sbjct: 373 VRFAPALNVSEEEVTTGLDRFAAACE 398 >2CFB-A nrPDB Length = 411 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 62/382 (16%), Positives = 122/382 (31%), Gaps = 47/382 (12%) Query: 58 GKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGS 117 G + + AL+ S G P LL + + P + C+ Sbjct: 51 GHAHPEVIDALHAALEKGTSFGAPCLLENILAEMVIAAVPSVEMVRFVNSGTEACM---- 106 Query: 118 QQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP-LGCNIINVASDESGIVPDSLRDILS 176 + ++ + V+ E Y G G + + +S VP + Sbjct: 107 --AVLRLMRAYTQR-EKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPKATTAATL 163 Query: 177 RWKPEDAKNPQK------NTPKFLYTVPNGNNPTGNSLTSE-RKKEIYELARKYDFLIIE 229 D + + N + P N G + + EL ++Y L++ Sbjct: 164 TAPYNDLEAVSRLFEQYPNDIAGVILEPVVGN-AGFIPPDAGFLEGLRELTKQYGALLVF 222 Query: 230 DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVI---L 286 D+ FR+ + + G + K+I GL +G G +++ V Sbjct: 223 DEV-----MTGFRIAYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRAEIMKMVAPAGP 277 Query: 287 HIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE 346 Q TL + + L G H+DR+ +L AA ++ + Sbjct: 278 VYQAGTLSGNPLAMTAGIKTLEILSRPGSYEHLDRITGKL---VQGLLDAAREFGHEVCG 334 Query: 347 WHVPAAGMF-LWIKVKGI--------NDVKELIE--EKAVKMGVLMLPGNAFYVDSSAPS 395 H+ GMF L+ + +D+K+ ++ G+ + P S + Sbjct: 335 GHIS--GMFGLFFTAGPVTNYEQAKQSDLKKFAAFHRGMLEQGIYLAP-------SQFEA 385 Query: 396 PYLRASFSSASPEQMDVAFQVL 417 + + + A E+ A + + Sbjct: 386 GFTSLAHTEADIERTIAAARTV 407 >1B9H-A nrPDB Length = 388 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 41/124 (33%), Gaps = 19/124 (15%) Query: 113 VTSGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSL 171 VT+G L +++ + PG V++ + + Q+ LG + V D + D Sbjct: 59 VTNG-THALELALQVMGVGPGTEVIVPAFTFISSSQAAQRLGAVTVPVDVDAATYNLD-- 115 Query: 172 RDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDD 231 TP+ +P G + + +++ +++D Sbjct: 116 ----------PEAVAAAVTPRTKVIMPVHM--AGLMADMD---ALAKISADTGVPLLQDA 160 Query: 232 PYYF 235 + Sbjct: 161 AHAH 164 >1TAR-A nrPDB Length = 401 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 62/383 (16%), Positives = 130/383 (33%), Gaps = 46/383 (12%) Query: 16 PSPIRTMTDILSRGPKSM-ISLAGGL-PNPNMFPFKTAVITVENGKTIQFGEEMMKRALQ 73 P PI +T+ R S ++L G + N P+ + V + + ++M K + Sbjct: 12 PDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPY--VLNCVRKAEAMIAAKKMDK---E 66 Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTS---GSQQGL---CKVFEM 127 Y P AG+ + +L + + VT L + Sbjct: 67 YLPIAGLADFTRASAEL--------ALGENSEAFKSGRYVTVQGISGTGSLRVGANFLQR 118 Query: 128 IINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQ 187 +V L +P++ G + + + K+ Sbjct: 119 FFKFSRDVYLPKPSWGNHTPIFRDAGLQLQAYRYYDPKTCSLDFTGAMEDISKIPEKS-- 176 Query: 188 KNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY-----YFLQFNKFR 242 + +NPTG E+ KE+ + +K + L D Y + + + Sbjct: 177 -----IILLHACAHNPTGVDPRQEQWKELASVVKKRNLLAYFDMAYQGFASGDINRDAWA 231 Query: 243 VPTFLSMDVDGRVIRADSFSK-IISSGLRIG---FLTGPKPLIERVILHIQVS---TLHP 295 + F+ +D V+ + S++K + G R G + +RV +++ Sbjct: 232 LRHFIEQGID--VVLSQSYAKNMGLYGERAGAFTVICRDAEEAKRVESQLKILIRPMYSN 289 Query: 296 STFNQLMISQLLHEWGE--EGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAA- 352 N I+ L+ E + ++ V + D + + +++ K + H+ Sbjct: 290 PPMNGARIASLILNTPELRKEWLVEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQI 349 Query: 353 GMFLWIKVKGINDVKELIEEKAV 375 GMF + +K V+ L +E ++ Sbjct: 350 GMFCFTGLKPEQ-VERLTKEFSI 371 >5W70-A nrPDB Length = 445 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 68/216 (31%), Gaps = 35/216 (16%) Query: 117 SQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 L E I GD V++ ++ + ++ LG N + + D + PD+L Sbjct: 97 GTASLMLALEACGIGAGDEVIVPGLSWVASGSTI--LGVNAVPIFCD---VDPDTLC--- 148 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYF 235 PE + + + V + + +A ++ +IED Sbjct: 149 --LSPEAVEAAITEHTRAIVVVHLYS-------ALADMDALSAIAERHGLPLIEDCAQAH 199 Query: 236 -LQFNKFRVPTFLSMDVDGRVIRADSF----SKIISSGLRIGFLTGPKPLIERVILHI-- 288 + +V A +F SK+++SG +T + RV Sbjct: 200 GATYRGVKVGALA---------TAGTFSMQHSKVLTSGEGGAVITRDEDFARRVEHLRAD 250 Query: 289 -QVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVI 323 + + P + + + G ++ I Sbjct: 251 GRCLSAVPPAPGAMELVETGELMGNNRCLSEFQAAI 286 >4GSA-A nrPDB Length = 432 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 58/348 (16%), Positives = 115/348 (33%), Gaps = 40/348 (11%) Query: 58 GKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGS 117 G E +K A++ S G P L + + P + C+ Sbjct: 72 GHAHPEVIEALKVAMEKGTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGTEACM---- 127 Query: 118 QQGLCKVFEMIINPGDNVLLDEPAYSGTLQSL---HPLGCNIINVASDESGIVPDSLRDI 174 + ++ D ++ E Y G G + + S + + Sbjct: 128 --AVLRLMRAYTGR-DKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTL 184 Query: 175 LSRW-KPEDAKNPQKNTPKFLYTV---PNGNNPTGNSLTSE-RKKEIYELARKYDFLIIE 229 + + E K P + V P N +G + + + E+ ++D L++ Sbjct: 185 TTPYNDLEAVKALFAENPGEIAGVILEPIVGN-SGFIVPDAGFLEGLREITLEHDALLVF 243 Query: 230 DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVI---L 286 D+ FR+ + G + KII GL +G G + +++ V Sbjct: 244 DEV-----MTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGP 298 Query: 287 HIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE 346 Q TL + + L + G ++D++ D +LA A + TG A Sbjct: 299 MYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQIT---KRLSDGLLAIAQE--TGHAA 353 Query: 347 WHVPAAGMFLWIKVKGI---------NDVKEL--IEEKAVKMGVLMLP 383 +GMF + +G +D+++ ++ G+ + P Sbjct: 354 CGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAP 401 >4WB0-B nrPDB Length = 414 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 55/375 (14%), Positives = 106/375 (28%), Gaps = 55/375 (14%) Query: 14 RNPSPIRTMTDILS--RGPKSMISLAG-----GLPNPNMFPFKTAVITVENGKTIQFGEE 66 R P PI + + +GPK+ + + GLP P K + ++ Sbjct: 21 RAPDPIFELAKRAAAAKGPKANLVIGAYRDEQGLPYPLRVVRKAEQLLLD---------- 70 Query: 67 MMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFE 126 M +Y P +G ++ + + + T L + Sbjct: 71 -MNLNYEYLPISGYQP---FIDEAVKMTYGDTV-----ELENLVAVQTLSGTGALSLGAK 121 Query: 127 MIINPGD----NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED 182 ++ + D + L +P + + G I + E Sbjct: 122 LLTHVFDAEKTPIYLADPTWPNHYSIVKAAGWKDIRTYAYYDHKTLG--------LDFEG 173 Query: 183 AKNPQKNTPKFLYTVPN--GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL---Q 237 K P + + +NPTG + E+ EI L + D Y Sbjct: 174 MKKDILAAPDGSVFLLHQCAHNPTGVDPSQEQWNEIASLMLAKHHQVFFDSAYQGYASGS 233 Query: 238 FNKFRVPTFLSMDVDGRVIRADSFSKIIS-----SGLRIGFLTGPKPLIERVILHIQVST 292 + L V+ A SFSK + +G + L K V + Sbjct: 234 LDTDAYAARLFARRGIEVLLAQSFSKNMGLYSERAGT-LSLLLKDKTKRADVKSVMDSLI 292 Query: 293 ----LHPSTFNQLMISQLLH-EWGEEGFMAHVDRVIDFYSNQKDAILAAADKW-LTGLAE 346 P + +L + + A + + + + + + G E Sbjct: 293 RAEYTCPPAHGARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGRWE 352 Query: 347 WHVPAAGMFLWIKVK 361 + GMF ++ + Sbjct: 353 HVINQIGMFSFLGLS 367 >4ATP-A nrPDB Length = 456 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 48/339 (14%), Positives = 96/339 (28%), Gaps = 29/339 (8%) Query: 105 SQGQMDLCVTSGSQQGLCKVFE-MIINPG-DNVLLDEPAYSGTLQSLHPLGCNIINVASD 162 + + SG+ + + + + G D V+ + AY G L + ++ Sbjct: 123 DHAKRTVLFNSGA-EAVENAVKVARLATGRDAVVAFDHAYHGRTNLTMALTAKAMPYKTN 181 Query: 163 ESGIVPDSLR-----------------DILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTG 205 P+ R + R K + + P G Sbjct: 182 FGPFAPEVYRMPMSYPFREENPEITGAEAAKRAITMIEKQIGGDQVAAIIIEPI-QGEGG 240 Query: 206 NSLTSE-RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKI 264 + +E + E A++ + I D+ R + ++D +G V + +K Sbjct: 241 FIVPAEGFLPALSEWAKEKGIVFIADEVQSGF----CRTGEWFAVDHEGVVPDIITMAKG 296 Query: 265 ISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVID 324 I+ GL + +TG L++ V T + + + + + Sbjct: 297 IAGGLPLSAITGRADLLDAVHPGGLGGTYGGNPVACAAALAAIDTMEQHDLNGRARHIEE 356 Query: 325 FYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPG 384 + + A + M V+ KE E + L Sbjct: 357 LALGKLRELAAELSAGGGSVVGDIRGRGAMLAIELVQPG--SKEPNAELTKAVAAACLKE 414 Query: 385 NAFYVDSSAPSPYLRASFSSA-SPEQMDVAFQVLAQLIK 422 + +R S E + +VLA IK Sbjct: 415 GVIILTCGTYGNVIRLLPPLVISDELLIDGLEVLAAAIK 453 >2X8U-A nrPDB Length = 412 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 87/290 (30%), Gaps = 40/290 (13%) Query: 48 FKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQG 107 F VI +FG + G LK+ H Sbjct: 59 FDPDVIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGTEHA----------- 107 Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIV 167 + ++G Q + + GD ++LD +++ I+ + Sbjct: 108 ---IVFSTG-YQANLGMISTLAGKGDYIILDADSHASIYDGCWLGDAEIVRFRHN----- 158 Query: 168 PDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLI 227 S+ D+ R A+ + + +Y++ G+ + +++K+ +I Sbjct: 159 --SVEDLDKRLGRLPAEAGKLVVLEGVYSM------MGDIAPLQEM---VAVSKKHGAMI 207 Query: 228 IEDDPYYFLQFNKFRVPTFLSMDVDGRV-IRADSFSKIISS-GLRIGFLTGPK---PLIE 282 + D+ + F + F V+ V +FSK + + G GF ++ Sbjct: 208 LVDEAHGMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVG---GFCVSNHPKFEVLR 264 Query: 283 RVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHV-DRVIDFYSNQKD 331 V + P + + + AH+ + +D Sbjct: 265 LVCRPYVFTASLPPSVVATAATSIRKLMHAGDKRAHLWKNSRRLHQGLRD 314 >5K8B-A nrPDB Length = 403 Score = 47.9 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 16/115 (13%), Positives = 35/115 (30%), Gaps = 19/115 (16%) Query: 117 SQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 L I GD V++ + +++++ G I +I Sbjct: 61 GTAALQTAMMAAGIGAGDEVIVPPFTFVASVEAIFMAGAVPI-------------FAEID 107 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 TP+ G + + EI + +K++ +++ED Sbjct: 108 ETLCLSPEGIEAVITPRTKAINLVHM--CG---SMAKMDEIKAICKKHNLVLLED 157 >2GMS-A nrPDB Length = 390 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 54/154 (35%), Gaps = 30/154 (19%) Query: 85 SWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMI------INPGDNVLLD 138 ++KQ + + Y + V+SGS L + + + GD +++ Sbjct: 34 EYVKQYETQFAKTFGSKYA-------VMVSSGSTANLLMIAALFFTKKPRLKKGDEIIVP 86 Query: 139 EPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVP 198 ++S T L G + V D + + E K ++ K + TV Sbjct: 87 AVSWSTTYYPLQQYGLRVKFVDIDINTL----------NIDIESLKEAVTDSTKAILTVN 136 Query: 199 NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDP 232 NP EI ++ D +++ED+ Sbjct: 137 LLGNP-------NNFDEINKIIGGRDIILLEDNC 163 >2HOR-A nrPDB Length = 427 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 54/363 (14%), Positives = 103/363 (28%), Gaps = 72/363 (19%) Query: 89 QLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQ-------GLCKVFEMIIN-PGDNVLLDEP 140 +L+ + + + + G Q L + P V+ P Sbjct: 104 ELEKTIKELHEVVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPDAPESKVVAHAP 163 Query: 141 AYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTP-KFLYTVPN 199 Y + D+ G V W A + P +++ V + Sbjct: 164 FYPVFREQTKYF---------DKKGYV----------WAGNAANYVNVSNPEQYIEMVTS 204 Query: 200 GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD 259 NNP G + A I D YY + T + D ++ Sbjct: 205 PNNPEG----------LLRHAVIKGCKSIYDMVYY------WPHYTPIKYKADEDILLF- 247 Query: 260 SFSK-IISSGLRIGFLTGPKPLI-ERVILHIQVSTLHPSTFNQLMISQLLHE-----WGE 312 + SK SG R G+ + ++ ++ +T QL ++L E + Sbjct: 248 TMSKFTGHSGSRFGWALIKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEVVAMVKTQ 307 Query: 313 EGFMAHVDRVIDFYSNQKDAILAAA-------------DKWLTGLAEWHVPAAGMFLWIK 359 +G M ++ ++ + A P + + W+K Sbjct: 308 KGTMRDLNTFGFKKLRERWVNITALLDQSDRFSYQELPQSEYCNYFRRMRPPSPSYAWVK 367 Query: 360 VKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQ 419 + D + + + G F A S Y+R S + + D L Sbjct: 368 CEWEED--KDCYQTFQNGRINTQNGVGF----EASSRYVRLSLIK-TQDDFDQLMYYLKD 420 Query: 420 LIK 422 ++K Sbjct: 421 MVK 423 >3NNK-A nrPDB Length = 411 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 55/170 (32%), Gaps = 29/170 (17%) Query: 75 SPSAGIPELLSWLKQLQIKLHNPPTIHYPPS-----------QGQMDLCVTSGSQQGLCK 123 P P +L + I ++P HY + + + V S+ G+ Sbjct: 20 GPINADPRVLRAMSSQLIGQYDPAMTHYMNEVMALYRGVFRTENRWTMLVDGTSRAGIEA 79 Query: 124 VFEMIINPGDNVLLDEPAYSGTL--QSLHPLGCNIINVASD-ESGIVPDSLRDILSRWKP 180 + I PGD VL+ G L + + + PD + D + R +P Sbjct: 80 ILVSAIRPGDKVLVPVFGRFGHLLCEIARRCRAEVHTIEVPWGEVFTPDQVEDAVKRIRP 139 Query: 181 EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 Q +T + + E+ E+ R+YD L D Sbjct: 140 RLLLTVQGDTSTTML---------------QPLAELGEICRRYDALFYTD 174 >2E54-A nrPDB Length = 385 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 32/222 (14%), Positives = 79/222 (35%), Gaps = 25/222 (11%) Query: 204 TGNS-LTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFS 262 +G T E +E +L +YD L++ D+ + + G V + + Sbjct: 184 SGIVPATKEFLEEARKLCDEYDALLVFDEVQCGMGRTGK----LFAYQKYGVVPDVLTTA 239 Query: 263 KIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRV 322 K + G+ IG + + + +T + ++ E +EGF+ V+ Sbjct: 240 KGLGGGVPIGAVIVNERA-NVLEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLEEVE-- 296 Query: 323 IDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKEL-IEEKAVKMGVLM 381 + + ++ + M L I ++ +V + K + +L+ Sbjct: 297 -----EKGNYLMKKLQEMKEEYDVVADVRG-MGLMIGIQFREEVSNREVATKCFENKLLV 350 Query: 382 LPGNAFYVDSSAPSPYLR-ASFSSASPEQMDVAFQVLAQLIK 422 +P + +R + ++D+A + L ++++ Sbjct: 351 VPA---------GNNTIRFLPPLTVEYGEIDLAVETLKKVLQ 383 >3WGB-A nrPDB Length = 341 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 90/285 (31%), Gaps = 49/285 (17%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y G+ L ++ L K + L V SG G+ Sbjct: 35 YGEDPGVNALEAYGADLLGK--------------EAALFVPSG-TMSNLLAVMSHCQRGE 79 Query: 134 NVLL--DEPAYSGTLQSLHPLGCNII-NVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 +L Y Q LG + V G + +L D+ + P+D T Sbjct: 80 GAVLGSAAHIYRYEAQGSAVLGSVALQPVPMQADGSL--ALADVRAAIAPDDVHF----T 133 Query: 191 PKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFL--- 247 P L + N +N G L +E+ EL ++ L + R+ + Sbjct: 134 PTRLVCLENTHN--GKVLPLPYLREMRELVDEHGL---------QLHLDGARLFNAVVAS 182 Query: 248 SMDVDGRVIRADSFSKIISSGLR--IG-FLTGPKPLIERVILHIQVSTLHPSTFNQLMIS 304 V V DS S +S GL +G L G I R ++ + + Sbjct: 183 GHTVRELVAPFDSVSICLSKGLGAPVGSLLVGSHAFIARARRLRKMVGGG------MRQA 236 Query: 305 QLLHEWGEEGFMAHVDRVIDFYSNQKDAI--LAAADKWLTGLAEW 347 +L + G HV R+ D + + LAA LA+ Sbjct: 237 GILAQAGLFALQQHVVRLADDHRRARQLAEGLAALPGIRLDLAQV 281 >4QGR-A nrPDB Length = 382 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 28/181 (15%), Positives = 56/181 (30%), Gaps = 23/181 (12%) Query: 55 VENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVT 114 ++ G E + A+ + G L + + + KL + + + Sbjct: 12 IDLGAQRARIENRLNAAISKVVAEGRYILGPEVAEFEKKLGEYLGVEH--------VIAC 63 Query: 115 SGSQQGLCKVFEMI-INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDES--GIVPDSL 171 + L I PG V + ++ T + + +G + V D + + L Sbjct: 64 ANGTDALQMPLMTRGIGPGHAVFVPSFTFAATAEVVALVGAEPVFVDVDPDSYNMNVEQL 123 Query: 172 RDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDD 231 ++ E P+ P L+ + N I +A + IIED Sbjct: 124 EAAIAATIKEGRLEPKAIIPVDLFGLAASYN------------RITAIAEREGLFIIEDA 171 Query: 232 P 232 Sbjct: 172 A 172 >1YAA-A nrPDB Length = 412 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 50/398 (12%), Positives = 113/398 (28%), Gaps = 58/398 (14%) Query: 50 TAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQM 109 + + +Y G+P L S ++ Q Sbjct: 45 KPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKI------IFGTQSDALQEDR 98 Query: 110 DLCV-TSGSQQGLCKVFEMIIN--PGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGI 166 + V + L + P V L +P ++ + G Sbjct: 99 VISVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTATYP------ 152 Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNG--NNPTGNSLTSERKKEIYELARKYD 224 + N + P+ V + +NPTG TSE+ +I + + Sbjct: 153 ---YWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQIVDAIASKN 209 Query: 225 FLIIEDDPYYFLQFNKFRVPTFL------SMDVDGRVIRADSFSK-IISSGLRIGFL--- 274 + + D Y + + V SF+K G R+G Sbjct: 210 HIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYGERVGCFHLA 269 Query: 275 --------TGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE-WGEEGFMAHVDRVIDF 325 T + ++ I+ +P + ++++LL E + + + Sbjct: 270 LTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSR 329 Query: 326 YSNQKDAILAAADKWL-TGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPG 384 + + A+ K G + V GMF + + ++++ V ++ Sbjct: 330 ITKMRHALRDHLVKLGTPGNWDHIVNQCGMFSFTGLTP-----QMVKRLEETHAVYLVAS 384 Query: 385 NAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIK 422 RAS + + ++ + + ++++ Sbjct: 385 G-------------RASIAGLNQGNVEYVAKAIDEVVR 409 >5TON-A nrPDB Length = 414 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 104/341 (30%), Gaps = 56/341 (16%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL-----CKV--F 125 +Y P G+ E + +L + +P Q G L + Sbjct: 71 EYLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQS-----LGGTGALRIGAEFLARWY 125 Query: 126 EMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV----ASDESGIVPDSLRDILSRWKPE 181 N V + P + G I +++ G+ L Sbjct: 126 NGTNNKDTPVYVSSPTWENLNGVFTTAGFKDIRSYRYWDTEKRGLDLQGFLSDLE----- 180 Query: 182 DAKNPQKNTPKFLYTVPNG--NNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYF---- 235 N P+F V + +NPTG T E+ K+I + ++ D Y Sbjct: 181 -------NAPEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASG 233 Query: 236 -LQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGL---RIG---FLTGPKPLIERVILHI 288 L+ + + + F+S + + A SFSK GL R+G + I RV+ + Sbjct: 234 NLEKDAWAIRYFVSEGFE--LFCAQSFSKNF--GLYNERVGNLTVVAKEPDSILRVLSQM 289 Query: 289 Q--VSTLHPSTFNQLMISQLLHEWGEEGFMAH---VDRVIDFYSNQKDAILAAADKWL-T 342 Q V + Q E F V + D + + + A + Sbjct: 290 QKIVRVTWSNPPAQGARIVARTLSDPELFHEWTGNVKTMADRILSMRSELRARLEALKTP 349 Query: 343 GLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLP 383 G GMF + + +E + + +LP Sbjct: 350 GTWNHITDQIGMFSFTGLNPKQ-----VEYLINQKHIYLLP 385 >5JAY-A nrPDB Length = 402 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 73/216 (33%), Gaps = 26/216 (12%) Query: 213 KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMD-VDGRVIRADSFSKIISSGLRI 271 + ELA ++ +I DD + F +I + K ++G+ Sbjct: 199 LPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTLDK--AAGVSG 256 Query: 272 GFLTGPKPLIERVILHIQVSTLHPSTFNQLMIS-----QLLHEWGEEGFMAHVDRVIDFY 326 F+ + +IE ++ + ++ + +++ + AH+ ++I Sbjct: 257 AFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIG-- 314 Query: 327 SNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNA 386 + A+L A W + + + G ND I + G L +P Sbjct: 315 --RTRAMLKA--------TPWLPVDSHTAVQPLIIGANDATLEIAATLDRAG-LWVPAIR 363 Query: 387 FYVDSSAPSPYLRASFSS----ASPEQMDVAFQVLA 418 + LR S S+ A ++++ Q L Sbjct: 364 -PPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQLG 398 >5LL2-A nrPDB Length = 480 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 35/213 (16%), Positives = 69/213 (32%), Gaps = 18/213 (8%) Query: 209 TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG 268 E + +Y+ ++ L D+ L D++ S K ++SG Sbjct: 259 PEEYMQLVYKFCHEHGILFAIDEVNQGLGRTGKMWAIQQFKDIEPD---LMSVGKSLASG 315 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSN 328 + + + G K +++ + + T + L EG + Y+ Sbjct: 316 MPLSAVIGKKEVMQSLDAPAHLFTTAGNPVCSAASLATLDVIEYEGLVEK-SATDGAYAK 374 Query: 329 QKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK---GINDVKELIEEKAVKMGVLMLPGN 385 Q+ + + + W + G+ L K +D + A GV+++ Sbjct: 375 QRFLEMQQRHPMIGDVRMWGL-NGGIELVKDPKTKEPDSDAATKVIYYAFAHGVVII--- 430 Query: 386 AFYVDSSAPSPYLRASFSSA-SPEQMDVAFQVL 417 + LR EQ+D A QVL Sbjct: 431 ------TLAGNILRFQPPLVIPREQLDQALQVL 457 >5VIU-A nrPDB Length = 419 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 31/227 (13%), Positives = 75/227 (33%), Gaps = 28/227 (12%) Query: 204 TGNSLTSE-RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFS 262 G + +E K+ EL +K++ L I D+ + ++ DV ++ Sbjct: 213 AGVYVPNEGFLKQSSELCKKHNVLFIADEVQTGIARTG-KLIACHHEDVQPDILILG--- 268 Query: 263 KIISSG-LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDR 321 K +S G + + +++ + ST + + L +E ++ Sbjct: 269 KALSGGMYPVSAVLANNNIMDVIKPGQHGSTFGGNPLACAVAMAALDVVQDEKLSERAEK 328 Query: 322 VIDFYSNQKDAILAAADK----WLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKM 377 + + + ++ + ++ D GL L + L + Sbjct: 329 LGNLFRSEIEKLIEKTDLITKVRGKGLLNAI-------LINDTPDSSTAWNLCL-ALKEN 380 Query: 378 GVLMLPGNAFYVDSSAPSPYLRASFSSA-SPEQMDVAFQVLAQLIKE 423 G+L P + +R + + EQ+ +++ + I E Sbjct: 381 GLLAKPTHG---------NIIRLAPPLVITEEQLLDCVKIIEKTILE 418 >3BB8-A nrPDB Length = 437 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 18/129 (13%), Positives = 34/129 (26%), Gaps = 26/129 (20%) Query: 111 LCVTSGSQQGLCKVFEMI---------INPGDNVLLDEPAYSGTLQSLHPLGCNIINVAS 161 + T+ + + PGD V+ + T+ G + V Sbjct: 80 VLTTTSGSSANLLALTALTSPKLGVRALKPGDEVITVAAGFPTTVNPTIQNGLIPVFVDV 139 Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELAR 221 D + ++ + K GN + +A Sbjct: 140 DIPTYNVN--ASLIEAAVSDKTKAIMIAHT------------LGNLFDLAEVRR---VAD 182 Query: 222 KYDFLIIED 230 KY+ +IED Sbjct: 183 KYNLWLIED 191 >3BS8-A nrPDB Length = 438 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 93/280 (33%), Gaps = 34/280 (12%) Query: 58 GKTIQFGEEMMKRALQYSPSAGIP-ELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSG 116 G T E +K+ +Y S G P E+ + L +L I I + + S Sbjct: 76 GHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLVIDRVPSVEI----------VRMVSS 125 Query: 117 SQQGLCKVFEMIINPG----DNVLLDEPAYSGTLQSLHP-LGCNIINVASDESGIVPDSL 171 + + G + +L E Y G SL G + + +S VP+ + Sbjct: 126 GTEATMSALR--LARGYTGRNKILKFEGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGI 183 Query: 172 RDILSRWKPEDAKNPQKNTPKF------LYTVPNGNNPTGNSLTSE-RKKEIYELARKYD 224 D ++ + +F + P N G E + + ++ +Y Sbjct: 184 AKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGN-MGVVPPQEGFLQGLRDITEQYG 242 Query: 225 FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERV 284 L+I D+ FRV + G K+I GL +G G ++E++ Sbjct: 243 SLLIFDEV-----MTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPVGAYGGKAEIMEQI 297 Query: 285 I---LHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDR 321 Q TL + + L + + + + + Sbjct: 298 APSGPIYQAGTLSGNPLAMTAGLETLKQLTPDSYKNFIKK 337 >4H51-A nrPDB Length = 420 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 45/315 (14%), Positives = 89/315 (28%), Gaps = 31/315 (9%) Query: 73 QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPG 132 +Y P +G ++ + ++ T+ L T G + + Sbjct: 82 EYLPISGYQP---FIDEAVKIIYG-NTVELENLVAVQTLSGTGAVSLGAKLLTRVFDAET 137 Query: 133 DNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPK 192 + L +P + + G I + P ++ E K P Sbjct: 138 TPIYLSDPTWPNHYGVVKAAGWKNI---CTYAYYDPKTVS-----LNFEGMKKDILAAPD 189 Query: 193 FLYTVPN--GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL---QFNKFRVPTFL 247 + + +NPTG + E+ EI L + D Y + L Sbjct: 190 GSVFILHQCAHNPTGVDPSQEQWNEIASLMLAKHHQVFFDSAYQGYASGSLDTDAYAARL 249 Query: 248 SMDVDGRVIRADSFSKIIS-----SGLRIGFLTGPKPLIERVILHIQVST----LHPSTF 298 V+ A SFSK + +G + L K V + P Sbjct: 250 FARRGIEVLLAQSFSKNMGLYSERAGT-LSLLLKDKTKRADVKSVMDSLIREEYTCPPAH 308 Query: 299 NQLMISQLLH-EWGEEGFMAHVDRVIDFYSNQKDAILAAADKW-LTGLAEWHVPAAGMFL 356 + +L + + A + + + + + + G E + GMF Sbjct: 309 GARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGSWEHVINQIGMFS 368 Query: 357 WIKVKGINDVKELIE 371 ++ + E + Sbjct: 369 FLGLSKAQ--CEYCQ 381 >6ONN-A nrPDB Length = 402 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 32/215 (14%), Positives = 67/215 (31%), Gaps = 20/215 (9%) Query: 213 KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGR-VIRADSFSKIISSGLRI 271 + ELA + ++ DD + F + +I + K ++G+ Sbjct: 199 LARLLELAEHHGAWLVVDDAHGFGVLGPQGRGAVAEAALRSPHLIVVGTLGK--AAGVSG 256 Query: 272 GFLTGPKPLIERVILHIQ--VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQ 329 F+ + +IE ++ + + T +S L G + + Sbjct: 257 AFVVAHETVIEWLVQRARPYIFTTASVPSAAHAVSASLRIIGGDEGEHRRAHLRS----- 311 Query: 330 KDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYV 389 L A + + W + + + G N+ + + L +P Sbjct: 312 ----LIALTRDMLKSTPWLPVDSHTAVQPLIIGSNEATLDVAASLDRAN-LWVPAIR-PP 365 Query: 390 DSSAPSPYLRASFSSA----SPEQMDVAFQVLAQL 420 + LR S S+A EQ++ A A+ Sbjct: 366 TVPEGTSRLRISLSAAHSHNDLEQLEHALMKTAEA 400 >4E3Q-A nrPDB Length = 473 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 56/185 (30%), Gaps = 16/185 (8%) Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE--RKKEIYEL 219 E G + L+R E + +T + P G + + I + Sbjct: 208 GEEGETEEQFVARLARELEETIQREGADTIAGFFAEPVMG--AGGVIPPAKGYFQAILPI 265 Query: 220 ARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG-LRIGFLTGPK 278 RKYD +I D+ +I SK +++G +G + Sbjct: 266 LRKYDIPVISDEVICGFGRTGNTWGCVTYDFTPDAIIS----SKNLTAGFFPMGAVILGP 321 Query: 279 PLIERVILHIQVSTLHPSTFNQ-------LMISQLLHEWGEEGFMAHVDRVIDFYSNQKD 331 L +R+ I+ P F + + + EG +V R+ + + Sbjct: 322 ELSKRLETAIEAIEEFPHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEERLK 381 Query: 332 AILAA 336 I Sbjct: 382 HIAER 386 >3MEB-A nrPDB Length = 448 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 46/334 (13%), Positives = 92/334 (27%), Gaps = 23/334 (6%) Query: 21 TMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGI 80 T+ PK + +L G E I ++ K +Y P AG Sbjct: 40 TVLYNADTNPKKV-NLGVGAYRDESGKPWILPAVKEAEAIIS--SDLSKYNKEYPPVAGF 96 Query: 81 PELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN---PGDNVLL 137 P L + + +GS + ++ P + Sbjct: 97 PLFLEAAQ--FLMFGKDSKAAQEGRIASCQSLSGTGS----LHIGFEFLHLWMPKAEFYM 150 Query: 138 DEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTV 197 + + + + + + D ++ + Sbjct: 151 PSTTWPNHYGIYDKVFNKLKVPYKEYTYLRKDG--ELEIDFSNTKKDIQSAPEKSIFLFH 208 Query: 198 PNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL---QFNKFRVPTFLSMDVDGR 254 +NP+G T + KE+ + ++ + D Y F + +D Sbjct: 209 ACAHNPSGIDFTEAQWKELLPIMKEKKHIAFFDSAYQGFATGSFEADAFAVRMFVDAGVE 268 Query: 255 VIRADSFSKIISS-GLRIGFL-TGPKPLIERVILHIQVSTLHPSTFN----QLMISQLLH 308 V+ A SFSK G RIG L + V + +S S + +H Sbjct: 269 VLVAQSFSKNFGLYGERIGCLHVVHAGVEGSVEKNKALSAAMVSGMTLQIRKTWSMSAIH 328 Query: 309 EWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLT 342 + H R++ + + + A + + Sbjct: 329 GAYIVQVIVHDKRLLQMFYDNVKEMSARIHRMRS 362 >3VK2-A nrPDB Length = 398 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 47/327 (14%), Positives = 92/327 (28%), Gaps = 56/327 (17%) Query: 119 QGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH----PLGCNIINVASDESGIVPDSLRDI 174 + ++ PGD VLL Y T LH G + +V Sbjct: 91 GAITSTLWTLLRPGDEVLLGNTLYGHTFAFLHHGIGEFGVKLRHVDM------------- 137 Query: 175 LSRWKPEDAKNPQKNTPKFLYTVP-NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY 233 + TP + NP + + ++ARK+ ++ D+ Y Sbjct: 138 -----ADLQALEAAMTPATRVIYFESPANPN---MHMADIAGVAKIARKHGATVVVDNTY 189 Query: 234 Y--------FLQFNKFRVPTFLSMDVDGRV---IRADS---FSKIISSGLR--IGFLTGP 277 L + + G + I S +I GL+ G + P Sbjct: 190 CTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLSP 249 Query: 278 KP---LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDF--YSNQKDA 332 L+ + H + N ++++ L + + H + F Y+ + Sbjct: 250 HDAALLMRGIKTLNLRMDRHCA--NAQVLAEFLARQPQVELI-HYPGLASFPQYTLARQQ 306 Query: 333 ILA----AADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFY 388 + A + G+ + L+ + + D + L + A P Sbjct: 307 MSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEER-- 364 Query: 389 VDSSAPSPYLRASFSSASPEQMDVAFQ 415 +R S + + Q Sbjct: 365 AHYGISEGLVRLSVGLEDIDDLLADVQ 391 >5Z8A-A nrPDB Length = 437 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 82/301 (27%), Gaps = 43/301 (14%) Query: 37 AGGLPNPN---MFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGI---PELLSWLKQL 90 L +P+ F A +V G + E + RA + G P L S L QL Sbjct: 53 GAYLTDPDGRRWIDFDNARGSVVLGHGDEEVAEAIARAARGRSGVGTAWSPVLDSLLGQL 112 Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLH 150 Q Y L V + + D ++ Y G H Sbjct: 113 QEVCGGDVVGLYRT------------GTAALRSVTCAVRDARDRSIVLSSGYHGYDPMWH 160 Query: 151 PLGCNIINVASDESG-IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLT 209 DE + + L + + P+ + L Sbjct: 161 ----------CDEPFTPNQHGIVEFLFDLDVLAEWLSRPEQVAAVVISPDHMH-----LG 205 Query: 210 SERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGL 269 E L ++ D +I D+ L++ L V +K +++G Sbjct: 206 ERWYTEFTRLTKEADVPVIADEVKVGLRYRAGLSTPLLDPAVWI-------VAKCLANGS 258 Query: 270 RIGFLTGPKPLIERVILHIQVSTLHP--STFNQLMISQLLHEWGEEGFMAHVDRVIDFYS 327 + + G L+ + S P + ++ ++ A DR I Sbjct: 259 PVAAVGGDAHLLAALEDVSFTSYFEPTAMAAATTTLRRMATGEPQQAIRAAGDRFIAHTR 318 Query: 328 N 328 Sbjct: 319 A 319 >5W1B-A nrPDB Length = 467 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 42/319 (13%), Positives = 97/319 (30%), Gaps = 36/319 (11%) Query: 134 NVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAK----NPQKN 189 V + + T + GC IN+ + E ++ D + + K + Sbjct: 124 PVFISNFHFDTTAAHVELNGCKAINIVT-EKAFDSETYDDWKGDFDIKKLKENIAQHGAD 182 Query: 190 TPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY--YFLQFNKFRVPTFL 247 + + N+ G ++ KE+YE+A+++ ++ D F K R P + Sbjct: 183 NIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIKARDPKYK 242 Query: 248 SMDVDGRVIRAD------SFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 + + + + S L IG L + E L Q Sbjct: 243 NATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPMEGFVTYG 302 Query: 302 MISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVK 361 ++ +G + Y + + D+ P G +++ K Sbjct: 303 GLAGRDMAAMVQGLEEGTEEEYLHY--RIGQVKYLGDRLREAGIPIQYPTGGHAVFVDCK 360 Query: 362 --------GINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSP--------YLRAS---- 401 + +I ++ GV + +F + + ++R + Sbjct: 361 KLVPQIPGDQFPAQAVINALYLESGVRAVEIGSFLLGRDPATGEQKHADMEFMRLTIARR 420 Query: 402 -FSSASPEQMDVAFQVLAQ 419 +++ + + A L + Sbjct: 421 VYTNDHMDYIADALIGLKE 439 >2E7J-A nrPDB Length = 371 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 50/346 (14%), Positives = 110/346 (31%), Gaps = 47/346 (13%) Query: 94 LHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLG 153 +H+ P G VT+G+++ V + V++DE + + + G Sbjct: 55 IHDFIHNQLPKFLGCDVARVTNGAREAKFAVMHSLAKKDAWVVMDENCHYSSYVAAERAG 114 Query: 154 CNIINVASDESG---IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTS 210 NI V + I P++ + K T P GN Sbjct: 115 LNIALVPKTDYPDYAITPENFAQTIEETKKRGEVVLALITY-----------PDGNYGNL 163 Query: 211 ERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLR 270 K+I ++ +YD ++ + Y + + D S K +++ Sbjct: 164 PDVKKIAKVCSEYDVPLLVNGAYAI----GRMPVSLKEIGAD---FIVGSGHKSMAASGP 216 Query: 271 IGFLTGPKP----LIERVILH--IQVSTLHPSTFNQLMISQLLH----EWGEEGFMAHVD 320 IG + + ++ R + +V L + +I+ + + + V+ Sbjct: 217 IGVMGMKEEWAEIVLRRSEKYKNKEVELLGCTARGATIITLMASFPHVRERIKRWDEEVE 276 Query: 321 RVIDFYSNQKDAILAAA--DKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMG 378 + F + + + + L +H + K KG + + Sbjct: 277 KARRFAAEMEKLGIKQLGDNPHNHDLMFFH-AEVLYEISKKAKGGRF---FLYRELKSRK 332 Query: 379 VLML-PGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 + + PG + Y + S S E++D ++I++ Sbjct: 333 IHGIKPGL---------TRYFKLSTYGLSDEEVDYVLNAFKEIIEK 369 >6CBN-A nrPDB Length = 438 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 37/251 (14%), Positives = 77/251 (30%), Gaps = 32/251 (12%) Query: 136 LLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLY 195 LL Y G +P + + G+V D + Sbjct: 145 LLLSAGYHGYDPMWYPSEA---PLEPNADGVV-----DFFFDLGLLRELLRAPERVAAVV 196 Query: 196 TVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN-KFRVPTFLSMDVDGR 254 P+ + L+ +E+ L +++ D+ L++ L+ DV Sbjct: 197 VSPDHMH-----LSPGWYRELRRLCSAAGVVLVADEVKVGLRYAPGLSTAELLAPDVWV- 250 Query: 255 VIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG 314 +K +++G + + G + L++ + S P+ + G E Sbjct: 251 ------VAKGMANGHAVSAVGGSRRLLKPLKEVSFTSFFEPTILAAADAALARVATG-EP 303 Query: 315 FMAHVDRVIDFYSNQKDAILAA-ADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEK 373 A + F + + A+ A + G F + V +++E + Sbjct: 304 QRAVREAGDRFLRHARKALDDASLPVEIAG-------DGTFFQF--VPATEELEEALYGA 354 Query: 374 AVKMGVLMLPG 384 A G+L G Sbjct: 355 ANAEGLLFYAG 365 >3K7Y-A nrPDB Length = 405 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 92/271 (33%), Gaps = 28/271 (10%) Query: 4 ARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGL---PNPNMFPFKTAVITVENGKT 60 + +++ + ++T + + I+L+ G+ + ++ F + V+ + T Sbjct: 2 DKLLSSLENIEVDNILKTAREFKEDTCEEKINLSIGVCCNDDGDLHIFDS-VLNADKLVT 60 Query: 61 IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG 120 + E+ Y G + S L Q I +N I ++ G Sbjct: 61 ENYKEKP------YLLGNGTEDF-STLTQNLIFGNNSKYI----EDKKICTIQCIGGTGA 109 Query: 121 LCKV--FEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRW 178 + + F ++N + + + P Y + + G N+ + + ++ DI Sbjct: 110 IFVLLEFLKMLNV-ETLYVTNPPYINHVNMIESRGFNLKYINFFDYNLI-----DINYDL 163 Query: 179 KPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQF 238 D +N + L NP ++ + EI E+ +II D Y Sbjct: 164 FLNDLRNIPNGSSVILQISCY--NPCSVNIEEKYFDEIIEIVLHKKHVIIFDIAYQGFGH 221 Query: 239 NKFRVPTFLSMDVDGRVI---RADSFSKIIS 266 L + + I SFSK +S Sbjct: 222 TNLEEDVLLIRKFEEKNIAFSVCQSFSKNMS 252 >5WT2-A nrPDB Length = 401 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 115/366 (31%), Gaps = 67/366 (18%) Query: 86 WLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMI-----INPGDNVLL--- 137 + + KL+ ++ D+ +TS + + V + + + G N ++ Sbjct: 47 AIAEALDKLYKGIN-----ARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTV 101 Query: 138 -DEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF-LY 195 + PA T L LG + + +E G + + + T K L Sbjct: 102 AEHPAVRSTCNFLESLGVEVTYLPINEHGSI-------------TAEQVREAITEKTALV 148 Query: 196 TVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRV 255 +V NN TG +EI + ++ L D + + +DV Sbjct: 149 SVMWANNETGLIFP---IEEIGAICKEKGVLFHTDAV---------QAIGKIPVDVLKAN 196 Query: 256 IRADSFS--KIISS----GLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHE 309 SFS K GL I G PL + + + + + + Sbjct: 197 ADFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKL 256 Query: 310 WGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKEL 369 E + V ++A+L D + G VP + ++G E Sbjct: 257 A-VEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEG-----EA 310 Query: 370 IEEKAVKMGVLMLPGNAFYVDSSAPSPYL--------------RASFSSASPE-QMDVAF 414 + + + G+A + +P + R S S + E ++D Sbjct: 311 MLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTI 370 Query: 415 QVLAQL 420 +V +Q Sbjct: 371 EVFSQA 376 >2E7U-A nrPDB Length = 424 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 75/216 (34%), Gaps = 24/216 (11%) Query: 133 DNVLLDEPAYSGTLQSLHPLGC--NIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 D +L++ + + TL G + P+ LR++L R E A Sbjct: 149 DGLLVEAGSGALTLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIA------- 201 Query: 191 PKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMD 250 + P N G + +E + A+ Y L+I D+ + L + Sbjct: 202 --AIIFEPVVGN-AGVLVPTEDFLKALHEAKAYGVLLIADEVMTGFRLAFGGATELLGLK 258 Query: 251 VDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEW 310 D + KI+ GL G + ++E+V V + N L ++ L Sbjct: 259 PD-----LVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLAT- 312 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE 346 + ++ +Y+ +D + A + L + + Sbjct: 313 -----LELLEENPGYYAYLED-LGARLEAGLKEVLK 342 >6CJB-A nrPDB Length = 391 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 62/199 (31%), Gaps = 34/199 (17%) Query: 37 AGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLH- 95 AG P + T + K I GE L Y S + L Sbjct: 21 AGQEPCKSTGAVMTPIYATSTYKQIAPGEH-----LGYEYSRTQNPTRKAYEDCIASLES 75 Query: 96 NPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCN 155 + ++ + ++ GD+V+ + Y GT + Sbjct: 76 GQKGFAFASGMAAINTVID-------------LLGSGDHVVAMDDLYGGTFRLFD----K 118 Query: 156 IINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKE 215 + S+ S D PE+ + K L+ + +NP L ++ Sbjct: 119 VKTRTSNLSFSFIDM-------SVPENIEAAITPKTKLLW-LETPSNP---MLKLANLRK 167 Query: 216 IYELARKYDFLIIEDDPYY 234 I +A+KY+ + + D+ + Sbjct: 168 IAAIAKKYNLITVADNTFA 186 >4BMK-A nrPDB Length = 442 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 65/205 (31%), Gaps = 27/205 (13%) Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGS------QQGLCKVFEMIINPGDNVLLDEPAYSG 144 L+ H Q D T+G+ + + G+ V+LD +++ Sbjct: 123 SRMLNGTFHDHMEVEQALRDFYGTTGAIVFSTGYMANLGIISTLAGKGEYVILDADSHAS 182 Query: 145 TLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPT 204 I+ + L L R E AK + Sbjct: 183 IYDGCQQGNAEIVRFR----HNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAP---- 234 Query: 205 GNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRV-IRADSFSK 263 KE+ +A+K+ +++ D+ + F + + ++G++ +FS Sbjct: 235 --------LKEMVAVAKKHGAMVLVDEAHSMGFFGPNGRGVYEAQGLEGQIDFVVGTFSA 286 Query: 264 IISS-GLRIGFLTGPKPLIERVILH 287 + + G GF+ P E V L Sbjct: 287 SVGTVG---GFVVSNHPKFEAVRLA 308 >5G4J-A nrPDB Length = 446 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 45/303 (14%), Positives = 94/303 (31%), Gaps = 35/303 (11%) Query: 105 SQGQMDLCVTSGSQQGLCKVFE-MIINPGDN-VLLDEPAYSGTLQSL----------HPL 152 L +T+ + + G+ VL+ + +Y G SL PL Sbjct: 108 DGALERLFLTNSGSEANELALRIARQHTGNTGVLVSDFSYHGNTTSLAEITTGLTVHEPL 167 Query: 153 GCNIINVASDE-----SGIVPDSLRDILSRWKPEDAKNPQKNT-PKFLYTVPNGNNPTGN 206 G ++ + + VP L L+ A P + Sbjct: 168 GAHVRALRIPDVSGIAEVDVPVLLEQSLADVDAAIASLQAAGHGVSVFLFDPLFSTEGLL 227 Query: 207 SLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS 266 L S + + R L+I D+ + + +V+ ++ K + Sbjct: 228 QLPSGYIEGVATRVRAAGGLVISDEVQSGFGRTGSGMWGYQMFNVEPELVTMG---KPMG 284 Query: 267 SGLRIGFLTGPKPLIERVILHIQ-VSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDF 325 +G IG + L++ H +T + + +L +E MA D++ + Sbjct: 285 NGHPIGAVVTTAELLDEFGRHNMFFNTFAGNPVSSAAGLAVLRYMDQEDLMAKADQLGKY 344 Query: 326 YSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV-------KGINDVKELIEEKAVKMG 378 + + I + + G+F I + + +++ E + G Sbjct: 345 IRKRLENIAQRSGNVGSVRGR------GLFFGIDIIESDGSRNPAPALTKILIEDMRERG 398 Query: 379 VLM 381 VL+ Sbjct: 399 VLI 401 >2DKJ-A nrPDB Length = 407 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 50/371 (13%), Positives = 107/371 (28%), Gaps = 49/371 (13%) Query: 66 EMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVF 125 E A Y I + S + L + P Q V+ Sbjct: 53 EGYPGARYYGGCEVIDRVESLAIERAKALFGAAWANVQPHS----------GSQANMAVY 102 Query: 126 EMIINPGDNVL---LDEPAYSGTLQSLHPLG----CNIINVASDESGIVPDSLRDILSRW 178 ++ PGD ++ L + ++ G V D I + +R + Sbjct: 103 MALMEPGDTLMGMDLAAGGHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLALEH 162 Query: 179 KPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQF 238 +P+ P+F K E+A + ++ D ++ Sbjct: 163 RPKVIVAGASAYPRFW-----------------DFKAFREIADEVGAYLVVDMAHFAGLV 205 Query: 239 NKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGP-KPLIERVILHIQ-VSTLHPS 296 P L + + K + G R G + L +R+ I P Sbjct: 206 AAGLHPNPLPYAH----VVTSTTHKTLR-GPRGGLILSNDPELGKRIDKLIFPGIQGGPL 260 Query: 297 TFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFL 356 + E + F + V++ + + + +TG + H+ Sbjct: 261 EHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARRGYRIVTGGTDNHL------F 314 Query: 357 WIKVKGINDVKELIEEKAVKMGVLMLP-GNAFYVDSSAPSPYLRA-SFSSASPEQMDVAF 414 + ++ + EE+ +G+ + F + +R + + + Sbjct: 315 LVDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEM 374 Query: 415 QVLAQLIKESL 425 ++A+LI +L Sbjct: 375 PLVAELIDRAL 385 >5IJG-A nrPDB Length = 427 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 65/213 (30%), Gaps = 19/213 (8%) Query: 105 SQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDES 164 + +SG + + PGD +L +P Y GT L N Sbjct: 96 EGAESAALFSSGMS-AIATTLFAFVRPGDVILHSQPLYGGTETLLAKTFFNF-------- 146 Query: 165 GIVPDSLRDILSRWKPEDAKNPQKNTPKF-LYTVPNGNNPTGNSLTSERKKEIYEL--AR 221 G+ + D + E A + + + NPT + + + + E AR Sbjct: 147 GVEAVAFADGVHEATIEKAAEEALAKGRVSVILIETPANPTNSIVDVAAVRRVAEKIEAR 206 Query: 222 KYDFLIIE-DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPL 280 + +I D+ F K + V S +I+ G + G K + Sbjct: 207 QGSRPVIACDNTLLGPVFQKPLDHG-ADLSVYSLTKYVGGHSDLIA-----GAVLGAKSV 260 Query: 281 IERVILHIQVSTLHPSTFNQLMISQLLHEWGEE 313 + +V + M+ + L G Sbjct: 261 VRQVKALRGAIGTQLDPHSCWMLGRSLETLGLR 293 >3GBX-A nrPDB Length = 420 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 39/237 (16%), Positives = 75/237 (31%), Gaps = 20/237 (8%) Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 Q V+ ++ PGD VL Q H + +N + IVP + + Sbjct: 101 GSQANFAVYTALLQPGDTVLGMN-----LAQGGHLTHGSPVNFSGKLYNIVPYGIDESGK 155 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 E AK +++ PK + + + +G ++ E+A + D + Sbjct: 156 IDYDEMAKLAKEHKPKMI--IGGFSAYSGVV----DWAKMREIADSIGAYLFVDMAHVAG 209 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLT---GPKPLIERVILHIQVSTL 293 P + + +G R G + G + L +++ + S Sbjct: 210 LIAAGVYPNPVPHAHVVTTTTHKTL-----AGPRGGLILAKGGDEELYKKLNSAVFPSAQ 264 Query: 294 HPSTF-NQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV 349 + L E E F + +V + L K ++G E H+ Sbjct: 265 GGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHL 321 >4IYO-A nrPDB Length = 397 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 47/152 (30%), Gaps = 28/152 (18%) Query: 91 QIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKV--------FEMIINPGDNVLLDEPAY 142 + HNP Y ++ G + +++ G +V+ + Y Sbjct: 58 YSRTHNPTRFAYERCVAALE-----GGTRAFAFASGMAATSTVMELLDAGSHVVAMDDLY 112 Query: 143 SGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNN 202 GT + V +G+ + P K + K ++ + N Sbjct: 113 GGTFRLFE-------RVRRRTAGLD----FSFVDLTDPAAFKAAIRADTKMVW-IETPTN 160 Query: 203 PTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 P L I +ARK+ L + D+ + Sbjct: 161 P---MLKLVDIAAIAVIARKHGLLTVVDNTFA 189 >3QI6-A nrPDB Length = 392 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 17/115 (14%), Positives = 39/115 (33%), Gaps = 16/115 (13%) Query: 120 GLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWK 179 ++ PGD+V++ + AY G + +G + L+ Sbjct: 93 AADCALRAMLRPGDHVVIPDDAY----------GGTFRLIDKVFTGWNVEYTPVALADL- 141 Query: 180 PEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 + + + T + ++ V NP L+ I +L ++ D+ + Sbjct: 142 -DAVRAAIRPTTRLIW-VETPTNP---LLSIADIAGIAQLGADSSAKVLVDNTFA 191 >3ECD-A nrPDB Length = 425 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 67/435 (15%), Positives = 125/435 (28%), Gaps = 55/435 (12%) Query: 2 NYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTI 61 N F + + A R+ S + L R + +A + AV+ + Sbjct: 4 NANPFFSQSLAERDASVRGAILKELERQQSQVELIA------SENIVSRAVLDAQGSVLT 57 Query: 62 QFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGL 121 E Y E+ + + +L N + P G Q Sbjct: 58 NKYAEGYPGKRYYGGCEFADEVEALAIERVKRLFNAGHANVQPHSGA----------QAN 107 Query: 122 CKVFEMIINPGDNVL---LDEPAYSGTLQSLHPLG----CNIINVASDESGIVPDSLRDI 174 V + PGD VL LD + G V+ D I D + + Sbjct: 108 GAVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLIDYDQVEAL 167 Query: 175 LSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 + KP P+ L +A ++ D + Sbjct: 168 AQQHKPSLIIAGFSAYPRKL-----------------DFARFRAIADSVGAKLMVDMAHI 210 Query: 235 FLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLH 294 R + + + K + G R GF+ I + I L Sbjct: 211 AGVIAAGRHANPVEHAH----VVTSTTHKTLR-GPRGGFVLTNDEEIAKKINSAVFPGLQ 265 Query: 295 PSTFNQLMISQLLH--EWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAA 352 ++ + + E + F ++DRV+ D + A +TG + H+ Sbjct: 266 GGPLMHVIAGKAVAFGEALTDDFKTYIDRVLANAQALGDVLKAGGVDLVTGGTDNHL--- 322 Query: 353 GMFLWIKVKGINDVKELIEEKAVKMGVLMLP-GNAFYVDSSAPSPYLRASFSSASPEQMD 411 L + ++ +E+ + G+ G F + + +R + + Sbjct: 323 ---LLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPTITSGIRLGTPAGTTRGFG 379 Query: 412 VA-FQVLAQLIKESL 425 A F+ + +LI E Sbjct: 380 AAEFREVGRLILEVF 394 >5X5H-A nrPDB Length = 392 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 46/319 (14%), Positives = 105/319 (32%), Gaps = 46/319 (14%) Query: 120 GLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWK 179 +F +I+ PGD+++L AY GT + + + + A V D+ Sbjct: 85 ATDILFRIILKPGDHIVLGNDAYGGTYRLI-----DTVFTAWGVEYTVVDT-------SV 132 Query: 180 PEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFN 239 E+ K K+ K ++ V NP L + + +L + ++ D+ + + Sbjct: 133 VEEVKAAIKDNTKLIW-VETPTNPA---LGITDIEAVAKLTEGTNAKLVVDNTFAS-PYL 187 Query: 240 KFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPK-PLIERVILHIQVSTLHPSTF 298 + + + S ++ G + + E ++ PS F Sbjct: 188 QQPLKLGAHAVLHSTTKYIGGHSDVVG-----GLVVTNDQEMDEELLFMQGGIGPIPSVF 242 Query: 299 NQLMISQLLH--EWGEEGFMAHVDRVIDFYSNQKDA--ILAAADKWLTG---LAEWHVPA 351 + + ++ L + + +++ +F ++ + +L K G A+ Sbjct: 243 DAYLTARGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRF 302 Query: 352 AGMFLWIKVKGIND-VKELIE--------------EKAVKMGVLMLPGNAFYVDSSAPSP 396 GM + ++ G + K+ E ++ M +A P Sbjct: 303 GGM-ISVRFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRD 361 Query: 397 YLRASFSSASPEQMDVAFQ 415 +R S E + + Sbjct: 362 LVRISIGIEDIEDLLADVE 380 >3MC8-A nrPDB Length = 316 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 79/253 (31%), Gaps = 29/253 (11%) Query: 167 VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYD-- 224 P+ P + P N N P T+E + + E+ + Sbjct: 15 APEQPAPQPEVAPPTTEQPAPAPAPGTTPGTENFNTPNATPETTEPRVLVSEVLVRPQSG 74 Query: 225 --FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS-------GLRIGFLT 275 +E Y ++ R T + D I F + + G+R+ F+ Sbjct: 75 QLTPELETQVYNVIRTQPGRTTTRSQLQEDINAIFGTGFFSNVQASPEDTPLGVRVSFIV 134 Query: 276 GPKPLIERVILHIQVSTLHPSTFNQLMISQLLH-EWGEEGFMAHVDRVIDFYSNQKD--- 331 P P++ +V + T PS Q ++ ++G+ + + I + + Sbjct: 135 QPNPVLSKVEIQANPGTNVPSVLPQATADEIFRAQYGKILNLRDLQEGIKELTKRYQDQG 194 Query: 332 ----AILAAADKWLTGLAEWHVPAAG---MFLWIKVKGINDVKE-------LIEEKAVKM 377 ++ A G+ V + + + K DV E ++ + Sbjct: 195 YVLANVVGAPQVSENGVVTLQVAEGVVENISVRFRNKEGQDVNEQGQPIRGRTQDYIITR 254 Query: 378 GVLMLPGNAFYVD 390 V + PG F + Sbjct: 255 EVELKPGQVFNRN 267 >6FYQ-A nrPDB Length = 484 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 44/137 (32%), Gaps = 8/137 (5%) Query: 205 GNSLTSER-KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSK 263 G + E I E+ Y L + D+ ++ + +F+K Sbjct: 254 GVIIPPEDYFLRIREVCNAYGILFVADEVITGFGRTGK----MFGIENWDVIPDVMTFAK 309 Query: 264 IISSG-LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRV 322 ++SG +G + P+ E + + H F + + +R+ Sbjct: 310 GVTSGYFPLGGVVVSDPIHEVLKEKSVGTLFH--GFTYSGHPTAAAVALKNIAIIKEERL 367 Query: 323 IDFYSNQKDAILAAADK 339 ++ DA+L K Sbjct: 368 VENSKRMGDALLHGLKK 384 >2VYC-A nrPDB Length = 755 Score = 36.7 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 38/117 (32%), Gaps = 15/117 (12%) Query: 113 VTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV-----------AS 161 V G+ + + + D V++D + Q L G + + Sbjct: 226 VVVGTSGSNRTIMQACMTDNDVVVVDRNCHKSIEQGLMLTGAKPVYMVPSRNRYGIIGPI 285 Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYE 218 + P++L+ +S K QK + Y V G ++ +++ E Sbjct: 286 YPQEMQPETLQKKISESPLTKDKAGQKPS----YCVVTNCTYDGVCYNAKEAQDLLE 338 >4GRX-A nrPDB Length = 465 Score = 36.3 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 26/182 (14%), Positives = 53/182 (29%), Gaps = 12/182 (6%) Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE--RKKEIYEL 219 E G L+R + +T + P G + + I + Sbjct: 200 GEEGETEAQFVARLARELEDTITREGADTIAGFFAEPVMG--AGGVIPPAKGYFQAILPI 257 Query: 220 ARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG-LRIGFLTGPK 278 RKYD +I D+ + +I SK +++G +G + Sbjct: 258 LRKYDIPMISDEVICGFGRTGNTWGCLTYDFMPDAIIS----SKNLTAGFFPMGAVILGP 313 Query: 279 PLIERVILHIQVSTLHPSTFNQLMI---SQLLHEWGEEGFMAHVDRVIDFYSNQKDAILA 335 L +RV ++ P F + + + + + + + +A L Sbjct: 314 DLAKRVEAAVEAIEEFPHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEAGLK 373 Query: 336 AA 337 Sbjct: 374 RI 375 >5VMB-A nrPDB Length = 425 Score = 35.9 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 30/239 (12%), Positives = 76/239 (31%), Gaps = 24/239 (10%) Query: 117 SQQGLCKVFEMIINPGDNVL---LDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRD 173 Q V+ ++NPGD VL L + + G V + + + Sbjct: 105 GSQANSAVYLALLNPGDTVLGMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYE 164 Query: 174 ILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY 233 + R E + P+ + + + + +R + ++A K + D + Sbjct: 165 EVERLALE-------HKPRMIVAGFSAYS---RVVDWQRFR---DIADKVGAYLFVDMAH 211 Query: 234 YFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLT--GPKPLIERVILHIQVS 291 P + + + + K + G R G + + + +++ + Sbjct: 212 VAGLVAAGVYPNPVQIAD----VTTTTTHKTLR-GPRSGLILAKANEEIEKKLQSAVFPG 266 Query: 292 TLHPSTFNQLMISQL-LHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV 349 + + + E + F A+ +V+ + +A ++G + H+ Sbjct: 267 NQGGPLMHAIAAKAICFKEAMSDDFKAYQQQVVKNAQAMAEVFIARGYDVVSGGTDNHL 325 >3ISL-A nrPDB Length = 416 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 38/221 (17%), Positives = 72/221 (32%), Gaps = 28/221 (12%) Query: 120 GLCKVFEMIINPGDNVLLDEPAYSGTL--QSLHPLGCNIINVASD-ESGIVPDSLRDILS 176 G+ V +I P D+VL+ G L + G N+ + + + P+ + + Sbjct: 74 GIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFDPEDIIREIK 133 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY-- 234 + KP+ T TG K I E R D L I D Sbjct: 134 KVKPKIVAMVHGETS------------TGRIHP---LKAIGEACRTEDALFIVDAVATIG 178 Query: 235 --FLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIG-FLTGPKPLIERVILHIQVS 291 ++ +++++ + + + + R+ + K + + + Sbjct: 179 GCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNE--RVADVIAARKKVERGIATQADRA 236 Query: 292 TLH---PSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQ 329 L P T N +SQL W E H + Y+ + Sbjct: 237 ALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYALR 277 >3HMU-A nrPDB Length = 472 Score = 35.9 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 46/168 (27%), Gaps = 9/168 (5%) Query: 164 SGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSL--TSERKKEIYELAR 221 G D L+R + + + + + G + EI + Sbjct: 195 EGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICD 254 Query: 222 KYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS-GLRIGFLTGP--K 278 KYD L+I D+ T + A S + G G + Sbjct: 255 KYDILLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIG---GSIVCDEVA 311 Query: 279 PLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFY 326 +I + + T + + L EE + HV V Y Sbjct: 312 HVIGKDEFNHGY-TYSGHPVAAAVALENLRILEEENILDHVRNVAAPY 358 >3NDN-A nrPDB Length = 414 Score = 35.9 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 32/202 (15%), Positives = 64/202 (31%), Gaps = 35/202 (17%) Query: 114 TSGSQQGLCKVFEMIINPGDNVL----LDEPAYSGTLQSLHPLGCNIINVASDESGIVPD 169 T+ + ++ GD ++ L + + L G + V D+ Sbjct: 102 TASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDD------ 155 Query: 170 SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIE 229 LS+W+ + P +NP + + ELA ++ Sbjct: 156 -----LSQWE------RALSVPTQAVFFETPSNP---MQSLVDIAAVTELAHAAGAKVVL 201 Query: 230 DDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRI--GFLTGPKPLIE-RVIL 286 D+ + P G + S +K I R+ G + G + I+ V Sbjct: 202 DNVFA--------TPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQK 253 Query: 287 HIQVSTLHPSTFNQLMISQLLH 308 ++ + S FN ++ + L Sbjct: 254 LMRHTGPAMSAFNAWVLLKGLE 275 >3G8M-A nrPDB Length = 417 Score = 35.6 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 34/237 (14%), Positives = 71/237 (29%), Gaps = 20/237 (8%) Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 Q V+ ++ PGD VL H + +N + IVP + Sbjct: 98 GSQANFAVYTALLEPGDTVLGMN-----LAHGGHLTHGSPVNFSGKLYNIVPYGIDATGH 152 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 + K +++ PK + + + +G ++ E+A + D + Sbjct: 153 IDYADLEKQAKEHKPKMI--IGGFSAYSGVV----DWAKMREIADSIGAYLFVDMAHVAG 206 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLT---GPKPLIERVILHIQVSTL 293 P + + +G R G + G + L +++ + Sbjct: 207 LVAAGVYPNPVPHAHVVTTTTHKTL-----AGPRGGLILAKGGSEELYKKLNSAVFPGGQ 261 Query: 294 HPSTF-NQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV 349 + L E E F + +V + L K ++G + H+ Sbjct: 262 GGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHL 318 >3WY7-A nrPDB Length = 404 Score = 35.6 bits (80), Expect = 0.042, Method: Composition-based stats. Identities = 49/359 (13%), Positives = 110/359 (30%), Gaps = 55/359 (15%) Query: 79 GIPELLSW--------LKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN 130 G+ L +W L +LH G V S + Sbjct: 80 GVEALRTWGGGAGGSRLVTGNTELHEAFEHQLASFLGAESALVFSSGYTANLGALVALSG 139 Query: 131 PGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNT 190 PG ++ D +++ + + ++ R T Sbjct: 140 PGSLIVSDALSHASLVDACRLSRARVVVSP---------------HRDVDAVDAALAART 184 Query: 191 PKFLYTVPNGNNPTGNSLTSER----KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTF 246 + V T + +++ ++++ + R++ L++ D+ + L R Sbjct: 185 EERAVVV------TESVFSADGDLAPLRDLHAVCRRHGALLLVDEA-HGLGVRGTRGQGL 237 Query: 247 LS---MDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMI 303 L + ++ + SK + G + G + GP+ + +I + + Sbjct: 238 LHEVGLAGAPDIVMTTTLSKAL--GSQGGAVLGPEAVRAHLIDTARSFIFDTGLAPAAVG 295 Query: 304 SQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGI 363 + + V+D AA + G+ E V A + + Sbjct: 296 AASAALRVLDAEPQRARAVLDR---------AAELATIAGVTEAPVSAVVSVILGDPEIA 346 Query: 364 NDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASF-SSASPEQMDVAFQVLAQLI 421 ++ V++G P A + LR + +S + ++M +A QVL ++ Sbjct: 347 VGAAAACLDRGVRVGCFRPPTVP------AGTSRLRLAARASLTDDEMALARQVLTDVL 399 >1Z7D-A nrPDB Length = 433 Score = 35.6 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 20/134 (14%), Positives = 47/134 (35%), Gaps = 6/134 (4%) Query: 204 TGNSLTSE-RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFS 262 G + S+ + +Y++ +KY+ L + D+ L ++ +V VI Sbjct: 225 AGVIVPSDNYLQGVYDICKKYNVLFVADEVQTGLGRTG-KLLCVHHYNVKPDVILLG--- 280 Query: 263 KIISSG-LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDR 321 K +S G I + ++ + ST + + + L+ E + ++ Sbjct: 281 KALSGGHYPISAVLANDDIMLVIKPGEHGSTYGGNPLAASICVEALNVLINEKLCENAEK 340 Query: 322 VIDFYSNQKDAILA 335 + + L Sbjct: 341 LGGPFLENLKRELK 354 >4LHD-A nrPDB Length = 983 Score = 35.6 bits (80), Expect = 0.045, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 56/174 (32%), Gaps = 25/174 (14%) Query: 32 SMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQ 91 SMI L N V E GK F + G L + L+ Sbjct: 523 SMIPLGSCTMKLNATAEMMPVTWPEFGKIHPFAPA--------GQTEGYQILFAQLEAWL 574 Query: 92 IKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDN----VLLDEPAYSGTLQ 147 ++ I P+ G G GL + + ++ G+ L+ E A+ Sbjct: 575 GEITGFDAISLQPNAGSQ------GEYAGLQVIRQYHLSRGEEQRNICLIPESAHGTNPA 628 Query: 148 SLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGN 201 S G ++ V D G + + D+ S+ + + + T P+ + Sbjct: 629 SAVMCGMQVVPVKCDGEGNI--DVEDLTSKAEKYGDRLAA-----LMVTYPSTH 675 >5U24-A nrPDB Length = 382 Score = 35.6 bits (80), Expect = 0.049, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 74/250 (29%), Gaps = 51/250 (20%) Query: 115 SGSQQGLCKVFEMI----INPGDNVLLDEPAYSGTLQSLHPLGCNIINVASD--ESGIVP 168 G GL + +I D +++ Y ++ ++ C I + D I P Sbjct: 75 IGVANGLDALRLIIKAYDFKENDEIIVPANTYIASILAITDNKCKPILIEPDINTYNINP 134 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 D + + +++ K + V G E+ + + A KY+ II Sbjct: 135 DLIEEKITK------------KTKAIMVVHLY----GQVCDMEKIQLL---ANKYNLKII 175 Query: 229 EDDPYYF-LQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILH 287 ED + RV G + A FS G +G G I Sbjct: 176 EDCAQAHGAIYKDKRV---------GNLGDAAGFS--FYPGANLG-ALGDAGCI------ 217 Query: 288 IQVSTLHPSTFNQLMISQLLHEWG-EEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAE 346 + N + L +G + + + + A L K+L Sbjct: 218 ------CTNDDNFASKIRALANYGSHKKYENLYTGLNSRLDEIQAAFLDIKLKYLDEDNN 271 Query: 347 WHVPAAGMFL 356 A +L Sbjct: 272 KRKNIANFYL 281 >1VJO-A nrPDB Length = 393 Score = 35.6 bits (80), Expect = 0.049, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 83/258 (32%), Gaps = 36/258 (13%) Query: 111 LCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTL--QSLHPLGCNIINVASDESGIVP 168 + V+ + + PGD VL+ Y G G ++ ++ + Sbjct: 88 IAVSGTGTAAMEATIANAVEPGDVVLIGVAGYFGNRLVDMAGRYGADVRTIS--KPWGEV 145 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 SL ++ + + + TG + + + EL R++ L++ Sbjct: 146 FSLEELRTALETHRPAILALVHAETS---------TGA---RQPLEGVGELCREFGTLLL 193 Query: 229 EDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLI---ERVI 285 D VP F +D G + K +G G P + Sbjct: 194 VDTVTSL-----GGVPIF--LDAWGVDLAYSCSQK------GLGCSPGASPFTMSSRAIE 240 Query: 286 LHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLA 345 + T + + + LL ++ + H I+ Y ++A+ A + L Sbjct: 241 KLQRRRTKVANWYLDM---NLLGKYWGSERVYHHTAPINLYYALREALRLIAQEGLANCW 297 Query: 346 EWHVPAAGMFLWIKVKGI 363 + H +LW +++ I Sbjct: 298 QRHQ-KNVEYLWERLEDI 314 >5TSU-A nrPDB Length = 422 Score = 35.2 bits (79), Expect = 0.050, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 68/230 (29%), Gaps = 47/230 (20%) Query: 42 NPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIH 101 +P + + V + T + G YS S G P + L++ L Sbjct: 45 DPEQWTSRAVVPPISLSTTFKQGAPGQHSGFNYSRS-GNPT-RNCLEKAVAALDGAKYCL 102 Query: 102 YPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHP----LGCNII 157 S + +T ++ GD ++ + Y GT G I Sbjct: 103 AFASGLAATVTITH------------LLKAGDQIICMDDVYGGTNLYFRQVASEFGLKIS 150 Query: 158 NVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYT-VPNGNNPTGNSLTSERKKEI 216 V + + TP+ + NPT + E I Sbjct: 151 FVDCSKIKL------------------LEAAITPETKLVWIETPTNPTQKVIDIEGCAHI 192 Query: 217 YELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS 266 + D +++ D+ + F + L++ D I S +K ++ Sbjct: 193 VH--KHGDIILVVDNTFMSPYFQR-----PLALGAD---ISMYSATKYMN 232 >6GIO-D nrPDB Length = 439 Score = 35.2 bits (79), Expect = 0.050, Method: Composition-based stats. Identities = 22/195 (11%), Positives = 53/195 (27%), Gaps = 32/195 (16%) Query: 66 EMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQG----QMDLCVTSG----- 116 AL Y G P ++ +++ + + YP + L +T G Sbjct: 50 SAGPAALGY----GHPAIVEAVEKSVRDMAGASLLLYPNEAAVSLAEDLLRITPGNGERR 105 Query: 117 ------SQQGLCKVFEMIINPG--DNVLLDEPAYSGTLQSLHPLGCNI----------IN 158 ++ ++ +Y G L + + + Sbjct: 106 VWFGHSGSDANDCAVRVLTAATKRSRIISFIGSYHGNLTGSMGISGHTAMTHTLPRPGVL 165 Query: 159 VASDESGIVPD-SLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIY 217 + P S +L A + ++ P ++ + + Sbjct: 166 LLPYPDPFRPRFSAEAVLELLDYHFATSCPPEQVAAVFIEPILSDGGLVVPPPAFLEALQ 225 Query: 218 ELARKYDFLIIEDDP 232 + RK+ L++ D+ Sbjct: 226 DRCRKHGILVVVDEV 240 >4BA4-A nrPDB Length = 459 Score = 35.2 bits (79), Expect = 0.055, Method: Composition-based stats. Identities = 51/333 (15%), Positives = 96/333 (28%), Gaps = 56/333 (16%) Query: 9 AASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMM 68 A +A R + +++ L+ L F T +++ M+ Sbjct: 72 AEAARRQMEELPFYNTFFKTTHPAVVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRMV 131 Query: 69 KRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMI 128 +R Y G PE + + + H T G + + Sbjct: 132 RR---YWDVQGKPEKKTLIGRWNG-YHGS----------------TIG--GASLGGMKYM 169 Query: 129 INPGDNVL-----LDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDA 183 GD + +++P + + + PD + +RW E Sbjct: 170 HEQGDLPIPGMAHIEQPWWYKHGKD-----------------MTPDEFGVVAARWLEEKI 212 Query: 184 KNPQKNTPKFLYTVPNGNNPTGNSL--TSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 + P G + + EI + RKYD L++ D+ Sbjct: 213 LEIGADKVAAFVGEPIQG--AGGVIVPPATYWPEIERICRKYDVLLVADEVICGF----G 266 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISSGL-RIGFLTGPKPLIERVI---LHIQVSTLHPST 297 R + G + +K +SSG IG + K + E +I T Sbjct: 267 RTGEWFGHQHFGFQPDLFTAAKGLSSGYLPIGAVFVGKRVAEGLIAGGDFNHGFTYSGHP 326 Query: 298 FNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 + + +EG + V I Y ++ Sbjct: 327 VCAAVAHANVAALRDEGIVQRVKDDIGPYMQKR 359 >3MAF-B nrPDB Length = 518 Score = 34.8 bits (78), Expect = 0.082, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 57/206 (27%), Gaps = 31/206 (15%) Query: 70 RALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLC--VTSGSQQGLCKVF-- 125 ALQ + P+L + + ++ +C VTSG + L Sbjct: 124 YALQSQSNPLHPDLWPSTAKFEAEVVAMTAHMLGGDAAGGTVCGTVTSGGTESLLLAMKT 183 Query: 126 --------EMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSR 177 + I P ++ A++ ++ G ++ D Sbjct: 184 YRDWARATKGITAP--EAVVPVSAHAAFDKAAQYFGIKLVRTPLDAD------------- 228 Query: 178 WKPEDAKNPQKNTPKFLYTV-PNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFL 236 ++ + A + TP + P G + EI LA ++ D Sbjct: 229 YRADVAAMREAITPNTVVVAGSAPGYPHGVV---DPIPEIAALAAEHGIGCHVDACLGGF 285 Query: 237 QFNKFRVPTFLSMDVDGRVIRADSFS 262 + D R+ S S Sbjct: 286 ILPWAERLGYPVPPFDFRLEGVTSVS 311 >6G4F-A nrPDB Length = 464 Score = 34.4 bits (77), Expect = 0.089, Method: Composition-based stats. Identities = 18/137 (13%), Positives = 38/137 (27%), Gaps = 10/137 (7%) Query: 207 SLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS 266 ++I ++ RKYD L+I D+ + ++ + S Sbjct: 235 VPPRTYWEKIQKVCRKYDILVIADEVICGFGRTGQMFGSQTFGIQPDIMVLSKQLSSSYQ 294 Query: 267 SGLRIGFLTGPKPLIERVILHIQVS-------TLHPSTFNQLMISQLLHEWGEEGFMAHV 319 I + P+ E + Q T + + L EE + H Sbjct: 295 P---IAAILINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHA 351 Query: 320 DRVIDFYSNQKDAILAA 336 ++ + + Sbjct: 352 AQMGQLLRSGLQHFIDH 368 >3I5T-A nrPDB Length = 476 Score = 34.4 bits (77), Expect = 0.099, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 56/172 (32%), Gaps = 23/172 (13%) Query: 167 VPDSLRDILSRWKPE--DAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYD 224 + D + P+ A + +P P G R K I K+D Sbjct: 206 LVQEFEDRIESLGPDTIAAFLAEPILASGGVIIP----PAGY---HARFKAI---CEKHD 255 Query: 225 FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGL-RIGFLTGPKPLIER 283 L I D+ + V +I +F+K ++SG +G L + ++ R Sbjct: 256 ILYISDEVVTGFGRCGEWFASEKVFGVVPDII---TFAKGVTSGYVPLGGLAISEAVLAR 312 Query: 284 VILHIQVSTLHPSTF---NQLMISQL----LHEWGEEGFMAHVDRVIDFYSN 328 + + + + NQ + + EG + + D+++ Sbjct: 313 ISGENAKGSWFTNGYTYSNQPVACAAALANIELMEREGIVDQAREMADYFAA 364 >2C44-A nrPDB Length = 471 Score = 34.4 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 62/191 (32%), Gaps = 14/191 (7%) Query: 48 FKTAVITVENGKTIQFGEEMMKRALQ-YSPSAGIPELLSWLKQLQIKLHN-PPTIHYPPS 105 F + G Q + M R + YS S L +K + + P Sbjct: 47 FIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAE 106 Query: 106 QGQMDLCVTSGSQQ-GLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV---AS 161 Q + + + Q+ GL + V + T GC + NV + Sbjct: 107 QIYIPVLIKKREQEKGLDRSKM--------VAFSNYFFDTTQGHSQINGCTVRNVYIKEA 158 Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELAR 221 ++G+ D + + N ++ N+ G ++ K +Y +A+ Sbjct: 159 FDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAK 218 Query: 222 KYDFLIIEDDP 232 KYD ++ D Sbjct: 219 KYDIPVVMDSA 229 >1IUG-A nrPDB Length = 352 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 39/357 (10%), Positives = 93/357 (26%), Gaps = 43/357 (12%) Query: 81 PELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGS-QQGLCKVFEMIINPGDNVLLDE 139 P+L + + + + + ++ + +GS + + + + PG+ VL+ Sbjct: 23 PQLHHRTEAAREVFLKARGLLREAFRTEGEVLILTGSGTLAMEALVKNLFAPGERVLVPV 82 Query: 140 PAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPN 199 L ++ D P ++ L Sbjct: 83 YGKFSERFYEIALEAGLVVERLDYPYGD-----------TPRPEDVAKEGYAGLLLVHSE 131 Query: 200 GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD 259 + TG ++ + + L+ D L ++++ G A Sbjct: 132 TS--TGALADLPALARAFK-EKNPEGLVGADMVTSLLV-------GEVALEAMGVDAAAS 181 Query: 260 SFSKIISSGLRIGFLTGPKPLIERVILHIQVSTL---------HPSTFNQLMISQLLHEW 310 K + +GF+ +ER+ L S + + L Sbjct: 182 GSQKGLMCPPGLGFVALSPRALERLKPRGYYLDLARELKAQKEGESAWTPAINLVLAVAA 241 Query: 311 GEEGFMAHVDRVIDFYSNQKDAILAAADK--WLTGLAEWHVPAAGMFLWIKVKGINDVKE 368 E + ++ + + Q + ++ + A +L V + Sbjct: 242 VLEEVLPRLEEHLALKAWQNALLYGVGEEGGLRPVPKRFSPAVAAFYLPEGVPYARVKEA 301 Query: 369 LIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL 425 + AV G R S A + + + + E + Sbjct: 302 FAQRGAVIAG----------GQGPLKGKVFRLSLMGAYDRYEALGVAGMFREVLEEI 348 >3NTJ-A nrPDB Length = 422 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 39/130 (30%), Gaps = 5/130 (3%) Query: 207 SLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS 266 + + L +KY+ L + D+ L ++ V VI K +S Sbjct: 210 VPSDSYFPGVASLCKKYNVLFVADEVQTGLGRTG-KLLCTHHYGVKPDVILLG---KALS 265 Query: 267 SG-LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDF 325 G I + ++ + ST + + + L E + D++ Sbjct: 266 GGHYPISAILANDDVMLVLKPGEHGSTYGGNPLAAAICVEALKVLINEKLCENADKLGAP 325 Query: 326 YSNQKDAILA 335 + L Sbjct: 326 FLQNLKEQLK 335 >2EO5-A nrPDB Length = 419 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 57/442 (12%), Positives = 135/442 (30%), Gaps = 90/442 (20%) Query: 34 ISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAG--------IPELLS 85 I LA +P +FP + +++G+ + + + L ++ G PE++ Sbjct: 12 IYLATSTRDPELFP-----LVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIK 66 Query: 86 WLKQLQIKLHNPPT---------------IHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN 130 + KL + + Y P Q + ++ + + +++ N Sbjct: 67 IGIEQMQKLAHAAANDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKN 126 Query: 131 PG-DNVLLDEPAYSG--------------TLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 G ++ + G + P +I+V P + Sbjct: 127 TGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPYPNPYRNPWHINGYE 186 Query: 176 SRWKPEDAKNPQKNTPKFLYTVPNG----------NNPTGNSLTSE-RKKEIYELARKYD 224 + + + F+ VP G + + E+ +LA+KY Sbjct: 187 NPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQKLAKKYG 246 Query: 225 FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERV 284 L+++D+ L +++ V + +K + G+ G + + Sbjct: 247 ILLVDDEVQMGLGRTGK----LFAIENFNTVPDVITLAKALGGGI---MPIGATIFRKDL 299 Query: 285 ILHIQVSTLHPSTFNQLMISQLLHEWG---EEGFMAHVDRVIDFYSNQKDAILAAADKWL 341 + H +TF ++ + + + HV+ + ++ + Sbjct: 300 DFKPGM---HSNTFGGNALACAIGSKVIDIVKDLLPHVNEIGKIFAEE-------LQGLA 349 Query: 342 TGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLR-A 400 + + + KV+ + K G+L+LP +R Sbjct: 350 DDVRGIGLAWGLEYNEKKVRDRIIGESF------KRGLLLLPA---------GRSAIRVI 394 Query: 401 SFSSASPEQMDVAFQVLAQLIK 422 S E+ +L ++IK Sbjct: 395 PPLVISEEEAKQGLDILKKVIK 416 >5XX1-A nrPDB Length = 756 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 45/140 (32%), Gaps = 19/140 (13%) Query: 113 VTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINV-----------AS 161 V G+ + + + D V+LD + Q L G + + Sbjct: 227 VVVGTSGSNRTIMQACMTDNDVVVLDRNCHKSIEQGLILTGAKPVYMVPSRNRYGIIGPI 286 Query: 162 DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELAR 221 + P++L+ +S K QK + Y+V G ++ +++ Sbjct: 287 YPQEMQPETLQKKISASPLTKTKAGQKPS----YSVVTNCTYDGVCYNAKEAQDLLAKTS 342 Query: 222 KYDFLIIEDDP-YYFLQFNK 240 D+ Y + +FN Sbjct: 343 DRIHF---DEAWYGYARFNP 359 >2CH1-A nrPDB Length = 396 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 22/193 (11%), Positives = 62/193 (32%), Gaps = 19/193 (9%) Query: 43 PNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHY 102 P + +I E KR L + + + L + ++ + + Sbjct: 5 PPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRTMDEVKDGLRYIF 64 Query: 103 PPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLL-DEPAYS-GTLQSLHPLGCNIINVA 160 +CV+ + G+ + ++ GD VL+ ++ ++ G ++ + Sbjct: 65 QTENRAT-MCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTIE 123 Query: 161 SDES-GIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYEL 219 ++L + +P+ ++ L + + + ++ Sbjct: 124 GPPDRPFSLETLARAIELHQPKCLFLTHGDSSSGLL---------------QPLEGVGQI 168 Query: 220 ARKYDFLIIEDDP 232 ++D L+I D Sbjct: 169 CHQHDCLLIVDAV 181 >5GQO-A nrPDB Length = 190 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 40/112 (35%), Gaps = 6/112 (5%) Query: 78 AGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLL 137 G EL + + +P + P L VT L + + GD+V++ Sbjct: 43 FGDQELYKFRVASNSRRRSPEG-TWEPGNS---LYVTVNCWGNLARGVSASLGKGDSVVV 98 Query: 138 DEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKN 189 Y+ + G +V + + PD R I K + ++ P+ + Sbjct: 99 VGHLYTNEYEDRE--GVRRSSVEVRATAVGPDLSRCIARVEKVQPSQGPRAD 148 >5EAV-A nrPDB Length = 441 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 48/138 (34%), Gaps = 8/138 (5%) Query: 212 RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG-LR 270 K +EL R + L+I D+ L R L+ D D K +S+G + Sbjct: 239 YLKRAHELCRSKNVLLIVDEIQTGL----CRTGRLLAADHDEVHPDILLLGKSLSAGVVP 294 Query: 271 IGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQK 330 I + G +++ + ST + + + L +E +R+ + + Sbjct: 295 ISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQF---R 351 Query: 331 DAILAAADKWLTGLAEWH 348 D + + + E Sbjct: 352 DCLRRELYGKVPWIKEIR 369 >4OTL-A nrPDB Length = 423 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 30/237 (12%), Positives = 69/237 (29%), Gaps = 19/237 (8%) Query: 115 SGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDI 174 + Q VF ++ PGD ++ H + +N++ +V L + Sbjct: 105 NSGSQANQGVFFAMLKPGDTIMGM-----SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEN 159 Query: 175 LSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDP-Y 233 K ++ PK + + + + ++A+ ++ D Y Sbjct: 160 EDIDYDAAEKLANEHKPKLIVAGAS------AFALKIDFERLAKIAKSVGAYLMVDMAHY 213 Query: 234 YFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTL 293 L D + K + G R G + + + I Sbjct: 214 AGLIAAGVYPNPVPHAD-----FVTTTTHKSLR-GPRGGVILMKAEYEKPINSAIFPGIQ 267 Query: 294 HPSTFNQLMISQ-LLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHV 349 + + E F + +V++ + ++ + ++G E HV Sbjct: 268 GGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETLVKRGLRIVSGRTESHV 324 >3BC8-A nrPDB Length = 450 Score = 33.2 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 30/195 (15%), Positives = 58/195 (29%), Gaps = 18/195 (9%) Query: 152 LGCNIINVAS----DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS 207 G + + + DE ++ + PE T F VP Sbjct: 164 AGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHSTTACFAPRVP--------- 214 Query: 208 LTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS 267 +R +E+ + YD + ++ Y LQ +K V S K Sbjct: 215 ---DRLEELAVICANYDIPHVVNNAYG-LQSSKCMHLIQQGARVGRIDAFVQSLDKNFMV 270 Query: 268 GLRIGFLTG-PKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFY 326 + + G +P I+ + + + L+ L G + + + Sbjct: 271 PVGGAIIAGFNEPFIQDISKMYPGRASASPSLDVLITLLSLGCSGYRKLLKERKEMFVYL 330 Query: 327 SNQKDAILAAADKWL 341 S Q + A ++ L Sbjct: 331 STQLKKLAEAHNERL 345 >4L0O-H nrPDB Length = 388 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 33/232 (14%), Positives = 72/232 (31%), Gaps = 39/232 (16%) Query: 123 KVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED 182 ++ GD+VLL + Y GT + + +V + L + + Sbjct: 79 HAVFSLLQSGDHVLLGDDVYGGTFRLFN-------------QVLVKNGLSCTIID-TSDI 124 Query: 183 AKNPQKNTPKFLYTVP-NGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 ++ + P +NP L + +A+ + L I D+ + + Sbjct: 125 SQIKKAIKPNTKALYLETPSNP---LLKITDLAQCASVAKDHGLLTIVDNTFATPYY--- 178 Query: 242 RVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQL 301 + P L D I A S +K +L G ++ ++ + F Q Sbjct: 179 QNPLLLGAD-----IVAHSGTK---------YLGGHSDVVAGLVTTNNEALAQEIAFFQN 224 Query: 302 MISQLLHEWGEEGFMAHVDRV---IDFYSNQKDAILAAADKWLTGLAEWHVP 350 I +L + + ++ + + +K + + P Sbjct: 225 AIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKH-PKVERVYYP 275 >1IBJ-A nrPDB Length = 464 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 39/252 (15%), Positives = 71/252 (28%), Gaps = 55/252 (21%) Query: 42 NPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIH 101 + PF + T + + Y+ S G P L+ L KL Sbjct: 95 DNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRS-GNPT-RDALESLLAKL------- 145 Query: 102 YPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSG----TLQSLHPLGCNII 157 + C TSG +I G+ ++ + Y G Q + G + Sbjct: 146 ---DKADRAFCFTSGM--AALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVK 200 Query: 158 NVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIY 217 V + K ++ K ++ + + NP ++I Sbjct: 201 RVNT----------------TKLDEVAAAIGPQTKLVW-LESPTNPRQQI---SDIRKIS 240 Query: 218 ELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGP 277 E+A L++ D+ P G I S +K F+ G Sbjct: 241 EMAHAQGALVLVDN--------SIMSPVLSRPLELGADIVMHSATK---------FIAGH 283 Query: 278 KPLIERVILHIQ 289 ++ V+ Sbjct: 284 SDVMAGVLAVKG 295 >3AXS-A nrPDB Length = 392 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 72/217 (33%), Gaps = 29/217 (13%) Query: 213 KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIG 272 K++ ELA +YD +I Y L + K ++ ++I + + Sbjct: 195 IKKVIELAAQYDIAMIPIFAYSHLHYFKLFFVKERGVEKVDKLIEQFGYIQYC------- 247 Query: 273 FLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG--FMAHVDRVIDFYSNQK 330 F + ++ + + S F+ + W EE F+ + + + Sbjct: 248 FNCMNREVVTDLYKFKEKCPHCGSKFHIGGPLWIGKLWDEEFTNFLYEEAQKREEIEKET 307 Query: 331 DAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPG--NAFY 388 IL K + L G ++ K+ +L + +++ V G F Sbjct: 308 KRILK-LIKEESQLQTV-----GFYVLSKLAEKV---KLPAQPPIRIAVKFFNGVRTHFV 358 Query: 389 VDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL 425 D + SF E++ + L + KE L Sbjct: 359 GDGFRTN----LSF-----EEVMKKMEELKEKQKEFL 386 >4U1T-A nrPDB Length = 389 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 17/118 (14%), Positives = 32/118 (27%), Gaps = 16/118 (13%) Query: 117 SQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILS 176 S Q ++ PG V+ + Y+GT + V + Sbjct: 75 SGQAAAATLLSLVRPGQCVVSTDDVYAGTDGLFDLAARQGVRVRYAD------------- 121 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYY 234 PE L + NP + E+ A + ++ D+ + Sbjct: 122 LTTPEGIAAALAEPDLALVWIETPTNPLLTVVD---VAEVSRRAHERGARVVVDNTFA 176 >5N3U-B nrPDB Length = 208 Score = 32.9 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 36/107 (33%), Gaps = 2/107 (1%) Query: 164 SGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKY 223 +G+ + L + E A L V NNPT ++ S ++ E+A Sbjct: 7 NGVALADTPEKLVKAVQELALAKDVAAIPTLIAVFGYNNPTAAAIASTALVQLGEVAVPQ 66 Query: 224 DFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLR 270 I+D Y ++ + + D+ + + +R Sbjct: 67 LLTQIDDYNYGARAYSIRTLAAIADPRALD--VLIDAAATDFAPSVR 111 >5KR3-A nrPDB Length = 479 Score = 32.9 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 19/134 (14%), Positives = 37/134 (27%), Gaps = 10/134 (7%) Query: 204 TGNSLTSE--RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + RK+D L+I D+ ++ + + A Sbjct: 251 TGGIIPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGSKMGSQHYGIKPDLITVAKGL 310 Query: 262 SKIISSGLRIGFLTGPK--PLIERVILHIQVS----TLHPSTFNQLMISQLLHEWGEEGF 315 + + G + G K +IE+ T L E Sbjct: 311 TSAYAP--LSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENL 368 Query: 316 MAHVDRVIDFYSNQ 329 + V + + Sbjct: 369 TGNAADVGAYLQQR 382 >5TXT-B nrPDB Length = 491 Score = 32.9 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 35/276 (12%), Positives = 73/276 (26%), Gaps = 57/276 (20%) Query: 71 ALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIIN 130 + Y + PE+L + + K + + + ++ Sbjct: 63 SNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTL--------NLEAELATLH 114 Query: 131 PGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGI--------------VPDSLRDILS 176 + L+ Y L LG + ++ + + Sbjct: 115 KKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDL 174 Query: 177 RWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPY--- 233 + ++ K+ PK + + G+ ++I +LA KY L D+ + Sbjct: 175 NELEQLLQSYPKSVPKLIAFESVYSM-AGSVAD---IEKICDLADKYGALTFLDEVHAVG 230 Query: 234 ----------YFLQFNKFRVPTFLSMDVD---------GRVIRA-DSFSKIISS-GLRIG 272 F R + + RV + K S G G Sbjct: 231 LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG---G 287 Query: 273 FLTGPKPLIERVILHI----QVSTLHPSTFNQLMIS 304 ++ + LI+ +TL PS + Sbjct: 288 YVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAA 323 >6IO1-A nrPDB Length = 451 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 36/105 (34%), Gaps = 6/105 (5%) Query: 205 GNSLTSE-RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSK 263 G + + I + RKY L+I D+ R T M G +F+K Sbjct: 234 GVVVPPDGYWPAIAAVLRKYGILLILDEVITGF----GRTGTLFGMQQYGVQPDIVTFAK 289 Query: 264 IISSGL-RIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLL 307 I+SG +G + + E + +V + + + Sbjct: 290 GITSGYVPLGGVGVSDEIAETLASADRVFMHGFTYSGHPVACAVA 334 >3HL2-A nrPDB Length = 501 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 29/195 (14%), Positives = 58/195 (29%), Gaps = 18/195 (9%) Query: 152 LGCNIINVAS----DESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS 207 G + + + DE ++ + P+ T F VP Sbjct: 182 AGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVP--------- 232 Query: 208 LTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS 267 +R +E+ + YD I ++ Y +Q +K V S K Sbjct: 233 ---DRLEELAVICANYDIPHIVNNAYG-VQSSKCMHLIQQGARVGRIDAFVQSLDKNFMV 288 Query: 268 GLRIGFLTG-PKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFY 326 + + G I+ + + + L+ L G + + + + Sbjct: 289 PVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYL 348 Query: 327 SNQKDAILAAADKWL 341 SNQ + A ++ L Sbjct: 349 SNQIKKLSEAYNERL 363 >2ZUK-A nrPDB Length = 439 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 28/239 (11%), Positives = 64/239 (26%), Gaps = 20/239 (8%) Query: 104 PSQGQMDLCVTSGSQQGLCKVFEMIINPGDN--VLLDEPAYSG-------------TLQS 148 P +G + + I+ V+ AY G + Sbjct: 100 PGEGTHKIWFGHSGSDANEAAYRAIVKATGRSGVIAFAGAYHGCTVGSMAFSGHSVQADA 159 Query: 149 LHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSL 208 G ++ D D + E + + P ++ Sbjct: 160 AKADGLILLPYPDPYRPYRNDPTGDAILTLLTEKLAAVPAGSIGAAFIEPIQSDGGLIVP 219 Query: 209 TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG 268 ++ ++ R + L++ D+ L + + +G V K + G Sbjct: 220 PDGFLRKFADICRAHGILVVCDEVKVGLARSGRLH----CFEHEGFVPDILVLGKGLGGG 275 Query: 269 LRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYS 327 L + + P +++ + TLH + + +L + A +R Sbjct: 276 LPLSAVIAPAEILD-CASAFAMQTLHGNPISAAAGLAVLETIDRDDLPAMAERKGRLLR 333 >3GJU-A nrPDB Length = 460 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 53/196 (27%), Gaps = 34/196 (17%) Query: 74 YSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGD 133 Y+ G PE + + + H V +GS GL P Sbjct: 135 YNNVLGRPEKKKIISRWRG-YHGSG--------------VMTGSLTGLDLFHNAFDLPRA 179 Query: 134 NVL-LDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPED-AKNPQKNTP 191 VL + P Y S D L +++ PE A + Sbjct: 180 PVLHTEAPYYFRRTDRSMS--------EEQFSQHCADKLEEMILAEGPETIAAFIGEPIL 231 Query: 192 KFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDV 251 VP P G ++I + +KYD L++ D+ + Sbjct: 232 GTGGIVPP---PAG------YWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIK 282 Query: 252 DGRVIRADSFSKIISS 267 + A + + Sbjct: 283 PDLITIAKGLTSAYAP 298 >5YKR-A nrPDB Length = 461 Score = 32.1 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 71/248 (28%), Gaps = 30/248 (12%) Query: 113 VTSGSQQGLCKVFEM--IINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDS 170 VT+ + V + +++ D V++ Y G++ + + +G+ P+ Sbjct: 135 VTTSATDANRFVLRLCRMLSGRDKVVVFNCNYHGSVDESQ-VEFDAAGRMVPRAGVHPNG 193 Query: 171 LRDILSRWKPEDAKNPQKNT------PKFLYTVPNGNNPTGNSLTSERKKE-IYELARKY 223 +R + E + T P N G +E + EL R++ Sbjct: 194 VRHATTTRLVEFNDLDALEAALAHGDVAAVLTEPFMTN-VGMVPPAEGFHAGLRELTRRH 252 Query: 224 DFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSG-----LRIG------ 272 D +I D+ + + ++ D K I+ G Sbjct: 253 DVALIIDE-THTISCGPAGYSGAHGLEPD-----FFVLGKCIAGGIPSAVWGCSQAQAER 306 Query: 273 -FLTGPKPLIERVILHIQVSTLHPSTFNQLMISQL-LHEWGEEGFMAHVDRVIDFYSNQK 330 + P + I H QL + E E H+ ++ Sbjct: 307 IWAVLPHFRPGQAINHFGFGGTLAGNALQLAAMRATFAEVMTEDAYRHMFQLAAQLEAGV 366 Query: 331 DAILAAAD 338 A L Sbjct: 367 RATLEELR 374 >5KQW-A nrPDB Length = 479 Score = 32.1 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 19/134 (14%), Positives = 36/134 (26%), Gaps = 10/134 (7%) Query: 204 TGNSLTSE--RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + KYD L+I D+ ++ + + A Sbjct: 251 TGGIIPPPQGYWEAIQAVLNKYDILLIADEVVCGFGRLGSKMGSQHYGMKPDLITVAKGL 310 Query: 262 SKIISSGLRIGFLTGPK--PLIERVILHIQVS----TLHPSTFNQLMISQLLHEWGEEGF 315 + + G + G K +IE+ T L E Sbjct: 311 TSAYAP--LSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENL 368 Query: 316 MAHVDRVIDFYSNQ 329 + V + + Sbjct: 369 TGNAADVGAYLQQR 382 >5LH9-A nrPDB Length = 458 Score = 31.7 bits (70), Expect = 0.55, Method: Composition-based stats. Identities = 25/180 (13%), Positives = 48/180 (26%), Gaps = 33/180 (18%) Query: 145 TLQSLHPLGCNIINVASDESGI----VPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNG 200 GC++++ P +L R E T L P Sbjct: 175 YNHGQLLAGCHLLDTPWLYRNPWDCRDPQALTAHCIRQLEEQIALLGAQTIAALIAEPVQ 234 Query: 201 NNPTGNSL--TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRA 258 G + ++ + E+ ++ L+I D+ + + Sbjct: 235 G--AGGVIVPPADYWPRLREVCDRHGILLIADEVVTGFGRSGCML--------------- 277 Query: 259 DSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAH 318 G R G+ P L + L + FNQ + + + G + H Sbjct: 278 ---------GSR-GWGVAPDILCLAKGITAGYIPLGATLFNQRIADAIENGQGFSHMIMH 327 >1ORD-A nrPDB Length = 730 Score = 31.7 bits (70), Expect = 0.57, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 34/95 (35%), Gaps = 12/95 (12%) Query: 112 CVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSG-TLQSLHPLGCNIINVASD-------- 162 V GS V +++ GD VL D + +L G + + ++ Sbjct: 193 FVLGGSSNANNTVTSALVSNGDLVLFDRNNHKSVYNSALAMAGGRPVYLQTNRNPYGFIG 252 Query: 163 ---ESGIVPDSLRDILSRWKPEDAKNPQKNTPKFL 194 +S +R++ ++ PE AK + + Sbjct: 253 GIYDSDFDEKKIRELAAKVDPERAKWKRPFRLAVI 287 >2CB1-A nrPDB Length = 412 Score = 31.7 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 77/249 (30%), Gaps = 46/249 (18%) Query: 38 GGLP-NPNMFPFKTAVITVENG-KTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLH 95 GLP +P+ G KT++ G+E Y + L++ L Sbjct: 10 AGLPEDPHGAVGLPIYAVAAYGFKTLEEGQERFATGEGYVYARQKDPTAKALEERLKAL- 68 Query: 96 NPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTL----QSLHP 151 +G ++ V + Q ++ PGD V+ + + T+ Q L Sbjct: 69 ----------EGALEAVVLASGQAATFAALLALLRPGDEVVAAKGLFGQTIGLFGQVLSL 118 Query: 152 LGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSE 211 +G + V + P+++R+ LS V NP Sbjct: 119 MGVTVRYVDPE-----PEAVREALSAKTRA-------------VFVETVANPALLV---P 157 Query: 212 RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS-GLR 270 + + LA + ++ D+ + G + +S +K S G Sbjct: 158 DLEALATLAEEAGVALVVDNTFGA-------AGALCRPLAWGAHVVVESLTKWASGHGSV 210 Query: 271 IGFLTGPKP 279 +G + Sbjct: 211 LGGAVLSRE 219 >6JEQ-A nrPDB Length = 675 Score = 31.7 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 14/42 (33%), Gaps = 4/42 (9%) Query: 200 GNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKF 241 +NP L K + + +I D Y ++ + Sbjct: 252 PHNPAARIL---ELKRLIQKLHARGLRVIMDVVYNH-VYDGY 289 >5KQT-A nrPDB Length = 479 Score = 31.3 bits (69), Expect = 0.78, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 21/66 (31%), Gaps = 2/66 (3%) Query: 204 TGNSL--TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + KYD L+I D+ ++ + + A Sbjct: 251 TGGIIVPPKGYWEAIQAVLAKYDVLLIADEVVCAFGRLGDKMGSQRHAMRPDLITTAKGL 310 Query: 262 SKIISS 267 + + Sbjct: 311 TSAYAP 316 >5GHG-A nrPDB Length = 456 Score = 31.3 bits (69), Expect = 0.86, Method: Composition-based stats. Identities = 17/182 (9%), Positives = 46/182 (25%), Gaps = 12/182 (6%) Query: 164 SGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNP----TGNSLT-SERKKEIYE 218 G +S +R E + P + P G + +++ Sbjct: 189 EGQAGESEEQFATRLADELEQLIIAEGPHTIAAFIGE--PVMGAGGVVVPPKTYWEKVQA 246 Query: 219 LARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD-SFSKIISSGLRIGFLTGP 277 + ++YD L+I D+ + + D+ ++ S I Sbjct: 247 VLKRYDILLIADEVICGFGRTGNLFGS-QTFDMKPDILVMSKQLSSSYLP---ISAFLIN 302 Query: 278 KPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAA 337 + + + + F E + ++ ++ + Sbjct: 303 ERVYAPIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQKRL 362 Query: 338 DK 339 + Sbjct: 363 RE 364 >5KR6-A nrPDB Length = 479 Score = 31.3 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 17/134 (12%), Positives = 34/134 (25%), Gaps = 10/134 (7%) Query: 204 TGNSLTSER--KKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + KYD L+I D+ + + A Sbjct: 251 TGGIVPPPEGYWEAIQAVLNKYDILLIADEVVCGFGRTGSMFGSHHYGMKPDLITVAKGL 310 Query: 262 SKIISSGLRIGFLTGPK--PLIERVILHIQVS----TLHPSTFNQLMISQLLHEWGEEGF 315 + + G + G K ++E+ T L E Sbjct: 311 TSAYAP--LSGVIVGEKVWKVLEQGSDQYGPIGHGWTYSGHPICAAAALANLDIIERENL 368 Query: 316 MAHVDRVIDFYSNQ 329 + ++ + Sbjct: 369 TGNAADTGAYFQQR 382 >5M46-A nrPDB Length = 440 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 20/182 (10%), Positives = 49/182 (26%), Gaps = 5/182 (2%) Query: 147 QSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGN 206 + G ++ D D + E + + P ++ Sbjct: 159 DAAKADGLILLPYPDPYRPYQDDPTGDAVLALLKERLAAVPAGSIAAAFIEPIQSDGGLI 218 Query: 207 SLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIIS 266 ++ ++ R + ++ D+ L + + +G V K + Sbjct: 219 VPPDGFLRKFADICRAHGISVVCDEVKVGLARSGRLH----CFEHEGFVPDILVLGKGLG 274 Query: 267 SGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFY 326 GL + + P +++ + TLH + +L E +R Sbjct: 275 GGLPLSAVIAPAEILD-CASAFAMQTLHGNPVCAAAGLAVLETIEAENLTTAAERKGKLL 333 Query: 327 SN 328 Sbjct: 334 RE 335 >5UM8-G nrPDB Length = 485 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 8/50 (16%), Positives = 19/50 (38%), Gaps = 1/50 (2%) Query: 376 KMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL 425 + + + PG FY +R ++ + S + Q + + + E Sbjct: 275 RKSIRIGPGQTFYATGDII-GNIRQAYCNISKDDWIRTLQRVGKKLAEHF 323 >3N5M-A nrPDB Length = 452 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 18/137 (13%), Positives = 43/137 (31%), Gaps = 8/137 (5%) Query: 209 TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRAD-SFSKIISS 267 + K ++E +K+ L+I D+ F++ DV +I + Sbjct: 234 PQDYMKAVHETCQKHGALLISDEVICGFGRTGKAF-GFMNYDVKPDIITMAKGITSAYLP 292 Query: 268 GLRIGFLTGPKPLIERVILHIQVSTL-HPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFY 326 + + + E + H +TF + L E + + +I+ Sbjct: 293 ---LSATAVKREIYEAFKGKGEYEFFRHINTFGGNPAACALALKNLE--IIENENLIERS 347 Query: 327 SNQKDAILAAADKWLTG 343 + +L + + Sbjct: 348 AQMGSLLLEQLKEEIGE 364 >5OGX-A nrPDB Length = 336 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 29/88 (32%), Gaps = 19/88 (21%) Query: 212 RKKEIYELARKYD----FLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISS 267 E+A ++ ++ D+P + F F+ GR Sbjct: 252 DLGRFAEIAEEHPGFRFVPVLSDEPDPAYR-GGFPTDAFVEDVPSGR------------- 297 Query: 268 GLRIGFLTGPKPLIERVILHIQVSTLHP 295 G G+L GP ++E + + + P Sbjct: 298 GW-SGWLCGPPAMVEAGVKAFKRRRMSP 324 >5KR5-A nrPDB Length = 479 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 36/135 (26%), Gaps = 12/135 (8%) Query: 204 TGNSLTSE--RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + RK+D L+I D+ + + + A Sbjct: 251 TGGIVPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGSKTGSEHYGIKPDLITVAKGL 310 Query: 262 SKIISSGLRIGFLTGPK---PLIERVILHIQVS----TLHPSTFNQLMISQLLHEWGEEG 314 + + + + + +IE+ V T L E Sbjct: 311 TSAYAP---LSAVIVSEKVWDVIEKGSREHGVMGHGWTYSGHPVCAAAALANLDILEREN 367 Query: 315 FMAHVDRVIDFYSNQ 329 + V + + Sbjct: 368 LTGNAADVGAYLQQR 382 >4G89-A nrPDB Length = 237 Score = 30.2 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 62/204 (30%), Gaps = 39/204 (19%) Query: 87 LKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTL 146 LK K+ + Q D+ + +GS GL ++ GD V+ DE Y Sbjct: 51 LKSGIGKVAAAMGATLLLERCQPDVIINTGSAGGLASTLKV----GDIVVSDEARY--HD 104 Query: 147 QSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTV--------- 197 + G + +G D + L K N + L Sbjct: 105 ADVTAFGYEYGQLPGCPAGFKAD---EKLVAAAESCIKALDLNAVRGLIVSGDAFINGSV 161 Query: 198 ----PNGNNPTGNSLTSERKKEIYELARKYDFLI-------IEDDPY--YFLQFNKFRVP 244 N P ++ E I + ++F + I D L F + Sbjct: 162 GLAKIRHNFPQAIAVEME-ATAIAHVC--HNFKVPFVVVRAISDVADQQSHLSFEE---- 214 Query: 245 TFLSMDVDGRVIRADSFSKIISSG 268 FL++ + ++ + ++ G Sbjct: 215 -FLAVAARQSTLMVENLVQNLARG 237 >2HUU-A nrPDB Length = 393 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 44/124 (35%), Gaps = 18/124 (14%) Query: 112 CVTSGSQQGLCKVFEMIINPGDNVLLDEPAY--SGTLQSLHPLGCNIINVASD-ESGIVP 168 C+++ G+ ++ GD +L+ + + G ++ V S + Sbjct: 74 CLSASGHGGMEATLCNLLEDGDVILIGHTGHWGDRSADMATRYGADVRVVKSKVGQSLSL 133 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 D +RD L KP Q ++ TG + + + L +++ L+I Sbjct: 134 DEIRDALLIHKPSVLFLTQGDSS------------TGV---LQGLEGVGALCHQHNCLLI 178 Query: 229 EDDP 232 D Sbjct: 179 VDTV 182 >6ERK-A nrPDB Length = 451 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 6/25 (24%), Positives = 14/25 (56%) Query: 208 LTSERKKEIYELARKYDFLIIEDDP 232 + + + + +L +YD L+I D+ Sbjct: 245 YSPQYLQLLRKLCDEYDVLLIADEI 269 >4RIT-B nrPDB Length = 486 Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 49/148 (33%), Gaps = 29/148 (19%) Query: 112 CVTSGSQQGLCKVFEM-------IINPGDNVLLDEP-------AYSGTLQSLHPLG---C 154 +TSG + + + PG L P A++ ++ LG Sbjct: 149 VLTSGGSLANLQALAVARNVAFDSVEPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTA 208 Query: 155 NIINV-ASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERK 213 +I V A+ +S + P+ LR + + + T N + Sbjct: 209 AVIPVRATADSRMDPEDLRARIDQARGAGQHPFCVVATAGTTTTGN----------IDPL 258 Query: 214 KEIYELARKYDFLIIEDDPYYF-LQFNK 240 EI +AR++ D Y L F++ Sbjct: 259 AEIGAIAREHGLWFHVDAAYGGALVFSE 286 >4WXB-A nrPDB Length = 428 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 38/295 (12%), Positives = 79/295 (26%), Gaps = 41/295 (13%) Query: 48 FKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQG 107 AV+ + E Y +A I + + + KL + P Sbjct: 51 VSKAVMAAQGTLLTNKYAEGYPGKRYYGGTAVIDVVETLAIERAKKLFGAKFANVQPHS- 109 Query: 108 QMDLCVTSGSQQGLCKVFEMIINPGDNVL---LDEPAYSGTLQSLHPLG----CNIINVA 160 Q V+ +I PGD V+ L + + G NV Sbjct: 110 ---------GSQANAAVYMSLIQPGDTVMGMDLSAGGHLTHGAPVSFSGKTYNFVSYNVD 160 Query: 161 SDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELA 220 + + D++ +P+ + + + E+A Sbjct: 161 KESELLDYDAILAQAKEVRPKLIVAGASAYSRII-----------------DFAKFREIA 203 Query: 221 RKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPL 280 ++ D + P+ + + + K + G R G + Sbjct: 204 DAVGAYLMVDMAHIAGLVASGHHPSPVPYAH----VTTTTTHKTLR-GPRGGLILTDDED 258 Query: 281 IERVILHIQVSTLHPSTFNQLMISQ--LLHEWGEEGFMAHVDRVIDFYSNQKDAI 333 I + + L ++ ++ L E + F + + VI + D Sbjct: 259 IAKKLNSAVFPGLQGGPLEHVIAAKAVALKEALDPAFKEYGENVIKNAAAMADVF 313 >3WKR-A nrPDB Length = 416 Score = 29.8 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 25/180 (13%), Positives = 57/180 (31%), Gaps = 27/180 (15%) Query: 114 TSGSQQGLCKVFEMIINPGDNVLLD-EPAYSGTLQSLHPLGCNIINVASDESGIV----P 168 T G+++G V I GD V+LD Y+ + + N+ V +E Sbjct: 118 THGAREGKFIVMHAICKEGDYVVLDKNAHYTSYVAA-ERAKLNVAEVGYEEEYPTYKINL 176 Query: 169 DSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLII 228 + ++++ + + N N K++ ++A++ + Sbjct: 177 EGYKEVIDNLEDKGKNVGLILLTHVDGEYGNLN----------DAKKVGKIAKEKGIPFL 226 Query: 229 EDDPY--YFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVIL 286 + Y + N V S K +++ G L + +++ Sbjct: 227 LNCAYTVGRMPVNGKEVKAD---------FIVASGHKSMAASAPCGILAFSEEFSDKITK 277 >6GWI-A nrPDB Length = 462 Score = 29.8 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 38/131 (29%), Gaps = 8/131 (6%) Query: 205 GNSLTSE-RKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSK 263 G + E + ++ KYD L++ D+ + + A S Sbjct: 230 GAIMPPESYWPAVKKVLAKYDILLVADEVICGFGRLGEWFGSQHYGLEPDLMPIAKGLSS 289 Query: 264 IISS-GLRIGFLTGPKP---LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHV 319 G G L G + LIE T + + L EG + V Sbjct: 290 GYLPIG---GVLVGDRVAETLIEEGGEFFHGFTYSGHPTCAAVALKNLELLEAEGVVDRV 346 Query: 320 DRVIDFYSNQK 330 + Y ++ Sbjct: 347 RDDLGPYLAER 357 >2IAE-B nrPDB Length = 407 Score = 29.8 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 23/77 (29%), Gaps = 2/77 (2%) Query: 147 QSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGN 206 + A E R++++ P + T+P +NPTG Sbjct: 30 PLSDLKWKEVKRAALSEMVEYITHNRNVITE--PIYPEVVHMFAVNMFRTLPPSSNPTGA 87 Query: 207 SLTSERKKEIYELARKY 223 E + E A + Sbjct: 88 EFDPEEDEPTLEAAWPH 104 >1UA7-A nrPDB Length = 422 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 13/31 (41%) Query: 209 TSERKKEIYELARKYDFLIIEDDPYYFLQFN 239 T + KE+ A +Y +I D F+ Sbjct: 73 TEQEFKEMCAAAEEYGIKVIVDAVINHTTFD 103 >2JAK-A nrPDB Length = 392 Score = 29.4 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 23/77 (29%), Gaps = 2/77 (2%) Query: 147 QSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGN 206 + A E R++++ P + T+P +NPTG Sbjct: 71 PLSDLKWKEVKRAALSEMVEYITHNRNVITE--PIYPEVVHMFAVNMFRTLPPSSNPTGA 128 Query: 207 SLTSERKKEIYELARKY 223 E + E A + Sbjct: 129 EFDPEEDEPTLEAAWPH 145 >5SW9-A nrPDB Length = 355 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 23/77 (29%), Gaps = 2/77 (2%) Query: 147 QSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGN 206 + A E R++++ P + T+P +NPTG Sbjct: 34 PLSDLKWKEVKRAALSEMVEYITHNRNVITE--PIYPEVVHMFAVNMFRTLPPSSNPTGA 91 Query: 207 SLTSERKKEIYELARKY 223 E + E A + Sbjct: 92 EFDPEEDEPTLEAAWPH 108 >2IST-A nrPDB Length = 325 Score = 29.4 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 20/59 (33%) Query: 150 HPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSL 208 LG + + ++ +DI ED N P+ L P NP G L Sbjct: 57 KVLGGEQVAINAEIEEEARFEPQDIPLDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVL 115 >2FQ6-A nrPDB Length = 415 Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 19/61 (31%), Gaps = 3/61 (4%) Query: 120 GLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWK 179 + I GD+VL+ + S + + S P DI+ + Sbjct: 109 AVANSILAFIEQGDHVLMTN---TAYEPSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQ 165 Query: 180 P 180 P Sbjct: 166 P 166 >4OBV-D nrPDB Length = 490 Score = 29.0 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 23/76 (30%), Gaps = 4/76 (5%) Query: 173 DILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDP 232 D + + P + N TG+ + EI L +K+D D Sbjct: 221 DTTKLEEAIETDKKSGYIPFVVIGTAGTTN-TGSI---DPLTEISALCKKHDMWFHIDGA 276 Query: 233 YYFLQFNKFRVPTFLS 248 Y + + L+ Sbjct: 277 YGASVLLSPKYKSLLT 292 >2CY8-A nrPDB Length = 453 Score = 29.0 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 37/113 (32%), Gaps = 9/113 (7%) Query: 141 AYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNG 200 Y+ P + ++ I PD + + + + F+ Sbjct: 159 GYNSHFDG-QPAPGVLPETTANTLLIRPDDIEGMREVFANHGSDIAA-----FIAEPVGS 212 Query: 201 NNPTGNS-LTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVD 252 + G + ++ +E ELAR+Y L I D+ + + L + D Sbjct: 213 HF--GVTPVSDSFLREGAELARQYGALFILDEVISGFRVGNHGMQALLDVQPD 263 >1VK3-A nrPDB Length = 615 Score = 29.0 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 51/158 (32%), Gaps = 14/158 (8%) Query: 205 GNSLTSERKKEIYELARKYDFL------IIEDDPYYFLQFNK--FRVPTFLSMDVDGRVI 256 + ++ I E+ARK+ +IE+ Y + N VP L + I Sbjct: 298 AVVTSPQKASRILEIARKHLLFGDVVAEVIEEPVYRVMYRNDLVMEVPVQLLANAPEEDI 357 Query: 257 RADSFSKIISSGL-RIGFLTGPK-PLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEG 314 + KI R+ F + E+ + T+ P F ++ + G Sbjct: 358 VEYTPGKI--PEFKRVEFEEVNAREVFEQYDHMVGTDTVVPPGFGAAVMR--IKRDGGYS 413 Query: 315 FMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAA 352 + H + ++A + L+ P A Sbjct: 414 LVTHSRADLALQDTYWGTLIAVLESVRKTLSVGAEPLA 451 >5KQU-A nrPDB Length = 479 Score = 29.0 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 21/66 (31%), Gaps = 2/66 (3%) Query: 204 TGNSL--TSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSF 261 TG + + I + KYD L+I D+ ++ + + A Sbjct: 251 TGGIIVPPKGYWEAIQAVLNKYDVLLIADEVVCAFGRLGSKMGSQRYGMRPDLITTAKGL 310 Query: 262 SKIISS 267 + + Sbjct: 311 TSAYAP 316 >5GP4-C nrPDB Length = 468 Score = 28.6 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 32/102 (31%), Gaps = 5/102 (4%) Query: 148 SLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNS 207 G ++IN + I + D W D + + T P N T Sbjct: 360 LTKLGGFSLINDGHELPLICYELTADSDREWTLYDLSDRLLMKGWQVPTYPLPKNMTDRV 419 Query: 208 LTSERKKEIYELARKYDFL-----IIEDDPYYFLQFNKFRVP 244 + + + ++ +DF+ I D + F+ P Sbjct: 420 IQRIVVRADFGMSMAHDFIDDLTQAIHDLDQAHIVFHSDPQP 461 >1WA5-C nrPDB Length = 960 Score = 28.6 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 19/60 (31%) Query: 171 LRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIED 230 L+ +P + + N +NP T E I ++ + ++ D Sbjct: 581 LQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPRFTHYTFESIGAILNYTQRQNLPLLVD 640 >5XVH-A nrPDB Length = 306 Score = 28.6 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 27/185 (14%), Positives = 59/185 (31%), Gaps = 20/185 (10%) Query: 83 LLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINP-GDNVLLDEP- 140 L Q I+ + P + L + G ++ L I G +++ P Sbjct: 124 FAERLAQYGIEFLDAPVTGGQKGAIEGTLTIMVGGKEELFHRLLPIFKAMGRDIVYMGPV 183 Query: 141 AYSGTLQSLHPLGCNIINVASDES-------GIVPDSLRDILSRWKPEDAKNPQKNTPKF 193 Y ++ ++ + + VA E G+ D + ++L+R + + PK Sbjct: 184 GYGQAMKLVNQVVVALNTVAMVEGLKLAKALGLDMDKVAEVLTR-GAARSGAIELYLPKL 242 Query: 194 LYTVPNGNNPTGNSLT--SERKKEIYELARKYDFLI----IEDDPYYFLQFNKFRVPTFL 247 L + G + + E ARK + + + Y + + Sbjct: 243 LKGDLSP----GFKAEHLKKDLGYVLEEARKRGVKLPGAELAYELYRKMVEDGAGSLGIH 298 Query: 248 SMDVD 252 ++ Sbjct: 299 ALGFY 303 >5LUC-A nrPDB Length = 403 Score = 28.6 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 20/124 (16%), Positives = 35/124 (28%), Gaps = 16/124 (12%) Query: 97 PPTIHYPPSQGQMDLCVTSGSQQ-GLCKVFEMIINPGDNVLLDEPAY--SGTLQSLHPLG 153 I Y V SGS L ++ PGD+ L+ + +G Sbjct: 72 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 131 Query: 154 CNIINVASDESG-IVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSER 212 + + D G + + L++ KP + TG + Sbjct: 132 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESS------------TGVLQPLDG 179 Query: 213 KKEI 216 E+ Sbjct: 180 FGEL 183 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.122 0.301 Lambda K H 0.267 0.0372 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,945,690 Number of Sequences: 36641 Number of extensions: 532327 Number of successful extensions: 2520 Number of sequences better than 10.0: 244 Number of HSP's better than 10.0 without gapping: 189 Number of HSP's successfully gapped in prelim test: 129 Number of HSP's that attempted gapping in prelim test: 1892 Number of HSP's gapped (non-prelim): 327 length of query: 425 length of database: 10,336,785 effective HSP length: 100 effective length of query: 325 effective length of database: 6,672,685 effective search space: 2168622625 effective search space used: 2168622625 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.9 bits)