BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q8LQ68 (506 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5ZQT-A nrPDB 947 0.0 4QS9-A nrPDB 647 0.0 1BDG-A nrPDB 274 6e-74 5HFU-A nrPDB 273 2e-73 4FOI-A nrPDB 271 4e-73 1BG3-A nrPDB 271 5e-73 3O1W-A nrPDB 265 4e-71 3HM8-A nrPDB 258 3e-69 3W0L-A nrPDB 251 5e-67 1IG8-A nrPDB 247 9e-66 4DCH-A nrPDB 238 5e-63 3B8A-X nrPDB 234 8e-62 2YHX-A nrPDB 39 0.004 1HKG-A nrPDB 36 0.031 4OVD-A nrPDB 33 0.20 5ZEP-H nrPDB 30 2.0 2IZO-A nrPDB 29 4.0 4B2T-A nrPDB 29 5.0 6FPX-A nrPDB 29 5.4 6D7W-A nrPDB 29 6.2 5HFZ-A nrPDB 29 6.2 >5ZQT-A nrPDB Length = 473 Score = 947 bits (2449), Expect = 0.0, Method: Compositional matrix adjust. Identities = 462/462 (100%), Positives = 462/462 (100%) Query: 45 AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL 104 AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL Sbjct: 12 AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL 71 Query: 105 FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 164 FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK Sbjct: 72 FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 131 Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME Sbjct: 132 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 191 Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS Sbjct: 192 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251 Query: 285 GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH 344 GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH Sbjct: 252 GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH 311 Query: 345 DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL 404 DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL Sbjct: 312 DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL 371 Query: 405 HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE 464 HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE Sbjct: 372 HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE 431 Query: 465 ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 506 ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE Sbjct: 432 ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 473 >4QS9-A nrPDB Length = 474 Score = 647 bits (1670), Expect = 0.0, Method: Compositional matrix adjust. Identities = 310/459 (67%), Positives = 377/459 (82%), Gaps = 2/459 (0%) Query: 44 RAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHG 103 R A+++ E+ +TP + LR +ADAM EM GL +D + LKMLISYVDNLP+GDE G Sbjct: 14 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKG 73 Query: 104 LFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV 163 LFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA L FV Sbjct: 74 LFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV 133 Query: 164 KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM 223 TE EDFHLPEGRQRELGFTF+FPV QTS+SSG+LIKWTKGFSI VG+DVV L++A+ Sbjct: 134 ATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKAL 193 Query: 224 ERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283 ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW GLLP+ Sbjct: 194 ERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPK 253 Query: 284 SGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343 SG MVINMEWGNF+S LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+LLK+A Sbjct: 254 SGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMA 313 Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403 DA+ FGD VP+KL FI+RTP MSAMH+DTS DLK +G+K+KDIL V TSL+ R + Sbjct: 314 EDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVV 373 Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463 + +C+++A RGARL+AAGIYGILKKLGRD + + Q++VIA+DGGL+EHY +F C+ Sbjct: 374 ISLCNIIATRGARLSAAGIYGILKKLGRDTTKDE--EVQKSVIAMDGGLFEHYTQFSECM 431 Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502 E++L +LLG+EA+ SV V +NDGSGIGAALLAASHS Y Sbjct: 432 ESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 470 >1BDG-A nrPDB Length = 451 Score = 274 bits (701), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 171/459 (37%), Positives = 253/459 (55%), Gaps = 31/459 (6%) Query: 51 EVEQRFSTPTALLRGIADAMVEEMERGLR--ADPHAPLKMLISYVDNLPTGDEHGLFYAL 108 E+ + F I D M E M GL+ + + +KM SYV P G E G F AL Sbjct: 14 EILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLAL 73 Query: 109 DLGGTNFRVIRVQLGGREK--RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 166 DLGGTN+RV+ V L G+ K R+ + Y IP M G+ ELF +IA L F++ Sbjct: 74 DLGGTNYRVLSVTLEGKGKSPRIQERTY---CIPAEKMSGSGTELFKYIAETLADFLENN 130 Query: 167 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226 G + ++ +LGFTFSFP Q ++ TL++WTKGFS +G G +V L ++++ Sbjct: 131 GM-----KDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185 Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGN 286 L++K A+VNDTVGTLA D A +I+GTGTN AY+E ++ + G+ + Sbjct: 186 ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV--KEPE 243 Query: 287 MVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343 +VIN EWG F + R+ +D ++D +SL+PG+Q+YEKM+SGMYLGE+VR I++ L Sbjct: 244 VVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLV 303 Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403 LF +P +L+ R L T ++ + D +H L + L D L V I Sbjct: 304 EQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIV 363 Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463 + C++V +R A LA AGI IL+++ R V + +DG LY+ + KF C Sbjct: 364 RYACEMVVKRAAYLAGAGIACILRRINRSEV----------TVGVDGSLYKFHPKF--CE 411 Query: 464 EAT-LADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501 T + D L + + ++L+ DGSG GAA +AAS ++ Sbjct: 412 RMTDMVDKL-KPKNTRFCLRLSEDGSGKGAAAIAASCTR 449 >5HFU-A nrPDB Length = 923 Score = 273 bits (697), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 175/461 (37%), Positives = 261/461 (56%), Gaps = 33/461 (7%) Query: 49 IEEVEQ-----RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDE 101 +++V+Q R S T L I+ +EME+GL A H A +KML ++V + P G E Sbjct: 25 VQKVDQYLYHMRLSDETLL--EISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 102 HGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELES 161 HG F ALDLGGTNFRV+ V++ + V + + AIP +M G+ +LFD IA L + Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 162 FV-KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 220 F+ K + +D LP LGFTFSFP HQT + L+ WTKGF +G G DVVA + Sbjct: 143 FMDKLQIKDKKLP------LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 196 Query: 221 RAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTG 279 +A++R+G D+ + A+VNDTVGT+ Y D++ +I+GTG+NA Y+E I G Sbjct: 197 KAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG 256 Query: 280 LLPRSGNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVR 336 G M INMEWG F + R+++D +D SLNPG+Q++EKMISGMY+GE+VR Sbjct: 257 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 313 Query: 337 RILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTS 396 IL+K+A + LFG + +L T D+S + + K ++ LG+ D + Sbjct: 314 LILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPT 370 Query: 397 LEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHY 456 E T +C +V+ R A L AA + +L+++ ++ G ++ R+ I +DG +Y+ + Sbjct: 371 QEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKH 426 Query: 457 KKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497 F L T+ L+ V + DGSG GAA++ A Sbjct: 427 PHFAKRLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTA 464 Score = 261 bits (667), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 169/440 (38%), Positives = 231/440 (52%), Gaps = 36/440 (8%) Query: 70 MVEEMERGLRADPHA--PLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREK 127 M EMERGL + HA P+KML +YV P G E G F ALDLGGTNFRV+ V++ + Sbjct: 497 MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 556 Query: 128 RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFP 187 V + AIP +M GT ELFD I + F++ G +G LGFTFSFP Sbjct: 557 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMG-----MKGVSLPLGFTFSFP 611 Query: 188 VHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGG 246 Q S+ L+KWTKGF +G GEDVV L A+ R+ D+ V A+VNDTVGT+ Sbjct: 612 CQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTC 671 Query: 247 RYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSERLP---R 303 + D +I+GTG+NA Y+E + G G M +NMEWG F R Sbjct: 672 GFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFR 728 Query: 304 SDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFIL 363 +++D A+D SLNPG+Q +EKMISGMYLGEIVR IL+ LF + +L+ R I Sbjct: 729 TEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIF 788 Query: 364 RTPDMSAMHHDT------SHDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARL 417 T +S + D L+HLG +++ + I VC +VA R A+L Sbjct: 789 ETKFLSQIESDCLALLQVRAILQHLG---------LESTCDDSIIVKEVCTVVARRAAQL 839 Query: 418 AAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAAS 477 AG+ ++ ++ +R G + + +DG LY+ + F + T+ DL Sbjct: 840 CGAGMAAVVDRIRENR----GLDALKVTVGVDGTLYKLHPHFAKVMHETVKDL---APKC 892 Query: 478 SVVVKLANDGSGIGAALLAA 497 V + DGSG GAAL+ A Sbjct: 893 DVSFLQSEDGSGKGAALITA 912 >4FOI-A nrPDB Length = 917 Score = 271 bits (694), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 181/469 (38%), Positives = 249/469 (53%), Gaps = 30/469 (6%) Query: 35 REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92 R AE+ R+ IEE F +L + M EME GLR H A +KML S+ Sbjct: 462 RLAEQHRQ------IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSF 515 Query: 93 VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152 V P G E+G F ALDLGGTNFRV+ V++ +KR V + AIP +M GT ELF Sbjct: 516 VRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF 575 Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212 D I + + F+ D+ +G + LGFTFSFP QTS+ +G LI WTKGF VG Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVG 630 Query: 213 EDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271 DVV L A++ R+ D+ V A+VNDTVGT+ Y + +I+GTG+NA Y+E Sbjct: 631 HDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEM 690 Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328 + G G M INMEWG F R+ YD +D SLN G+Q YEKMISG Sbjct: 691 KNVEMVEG---DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISG 747 Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388 MYLGEIVR IL+ LF + L+ R I T +S + D L + A L+ Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806 Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448 LG+ +++ + + VC +V+ R A+L AG+ ++ K+ +R G + + + Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGV 860 Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497 DG LY+ + F + T+ +L +V L+ DGSG GAAL+ A Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCNVSFLLSEDGSGKGAALITA 906 Score = 256 bits (655), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 165/435 (37%), Positives = 247/435 (56%), Gaps = 30/435 (6%) Query: 72 EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 129 +EM+ GL D P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+ + + Sbjct: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104 Query: 130 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KTEGEDFHLPEGRQRELGFTFSFPV 188 V + E P +++ G+ +LFD +A L F+ K + +D LP +GFTFSFP Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLP------VGFTFSFPC 158 Query: 189 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 247 Q+ I LI WTK F +G G DVV L++A++++G D + A+VNDTVGT+ Sbjct: 159 QQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218 Query: 248 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 304 Y D +I+GTGTNA Y+E I G G M IN EWG F + R+ Sbjct: 219 YDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275 Query: 305 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 364 ++D +D SLNPG+Q++EKM+SGMYLGE+VR IL+K+A + LF + +L R Sbjct: 276 EFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335 Query: 365 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 422 T D+SA+ + H+ K + + LGV + + + HVC +V+ R A L AA + Sbjct: 336 TSDVSAIEKNKEGLHNAKEILTR----LGVEPSDDDCVSVQ-HVCTIVSFRSANLVAATL 390 Query: 423 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 482 IL +L RD + G+ + RT + ++G LY+ + ++ TL L+ + S V Sbjct: 391 GAILNRL-RD---NKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVPD---SDVRFL 443 Query: 483 LANDGSGIGAALLAA 497 L+ GSG GAA++ A Sbjct: 444 LSESGSGKGAAMVTA 458 >1BG3-A nrPDB Length = 918 Score = 271 bits (693), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 177/469 (37%), Positives = 252/469 (53%), Gaps = 30/469 (6%) Query: 35 REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92 R AE+ R+ IEE F L + + EME GLR + + A +KML S+ Sbjct: 462 RLAEQHRQ------IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSF 515 Query: 93 VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152 V ++P G EHG F ALDLGGTNFRV+ V++ +KR V + +IP +M GT ELF Sbjct: 516 VRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELF 575 Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212 D I + + F+ D+ +G + LGFTFSFP HQT++ G LI WTKGF G Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEG 630 Query: 213 EDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271 DV + L A++ R+ D+ V A+VNDTVGT+ Y + +I+GTGTNA Y+E Sbjct: 631 HDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEM 690 Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328 + G G M INMEWG F R+D+D +D SLN G+Q +EKMISG Sbjct: 691 KNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISG 747 Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388 MYLGEIVR IL+ LF + L+ R I T +S + D L + A L+ Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806 Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448 LG+ +++ + + VC +V++R A+L AG+ +++K+ +R G + + Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGV 860 Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497 DG LY+ + F + T+ +L +V L+ DGSG GAAL+ A Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITA 906 Score = 255 bits (652), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 163/435 (37%), Positives = 246/435 (56%), Gaps = 30/435 (6%) Query: 72 EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 129 +EM+ GL D P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+ + + Sbjct: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104 Query: 130 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFH-LPEGRQRELGFTFSFPV 188 VS + E P +++ G+ +LFD +A L F++ + LP +GFTFSFP Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLP------VGFTFSFPC 158 Query: 189 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 247 Q+ I LI WTK F +G G DVV L++A++++G D + A+VNDTVGT+ Sbjct: 159 RQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218 Query: 248 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 304 Y D +I+GTGTNA Y+E I G G M IN EWG F + R+ Sbjct: 219 YDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275 Query: 305 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 364 ++D LD SLNPG+Q++EKM+SGMY+GE+VR IL+K+A + LF + +L R Sbjct: 276 EFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335 Query: 365 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 422 T D+SA+ D + K + + LGV + ++ + H+C +V+ R A L AA + Sbjct: 336 TSDVSAIEKDKEGIQNAKEILTR----LGVEPSDVDCVSVQ-HICTIVSFRSANLVAATL 390 Query: 423 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 482 IL +L RD + G+ + RT + +DG LY+ + ++ TL L+ + S V Sbjct: 391 GAILNRL-RD---NKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRFL 443 Query: 483 LANDGSGIGAALLAA 497 L+ G+G GAA++ A Sbjct: 444 LSESGTGKGAAMVTA 458 >3O1W-A nrPDB Length = 485 Score = 265 bits (676), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 167/461 (36%), Positives = 237/461 (51%), Gaps = 31/461 (6%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108 I +E F+ + +R I + E+++GL + + M+ +V PTG E G F AL Sbjct: 27 IHGLETLFTVSSEKMRSIVKHFISELDKGL-SKKGGNIPMIPGWVVEYPTGKETGDFLAL 85 Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGE 168 DLGGTN RV+ V+LGG +Q + +P HL GTS +L+ FIA L+ FV Sbjct: 86 DLGGTNLRVVLVKLGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV----- 138 Query: 169 DFHLPEGRQREL--GFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226 D P+G L GFTFS+P Q I+SG L +WTKGF I G G DVV L +E+ Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198 Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR--- 283 + + V AL+NDT GTL Y D +I+GTG N AY + + I K GLLP Sbjct: 199 NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIG 258 Query: 284 -SGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 M IN E+G+F +E LPR+ YD +D ES PG+Q +EKM SG YLGEI+R +LL Sbjct: 259 PDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLL 318 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 L +F D +KL++ +++ T S + D +L+ K L + T +E + Sbjct: 319 DLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERK 378 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 I + +LV R ARL G+ I K G + IA DG ++ Y ++ Sbjct: 379 LIR-KLAELVGTRAARLTVCGVSAICDKRGY----------KTAHIAADGSVFNRYPGYK 427 Query: 461 TCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 497 L D+ + + + A DGSG+GAA++A Sbjct: 428 EKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIAC 468 >3HM8-A nrPDB Length = 445 Score = 258 bits (660), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 177/465 (38%), Positives = 258/465 (55%), Gaps = 33/465 (7%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYA 107 ++EE F L + M + M +GLR + + L+ML ++V P G E G F A Sbjct: 5 LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASS-LRMLPTFVRATPDGSERGDFLA 63 Query: 108 LDLGGTNFRV--IRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165 LDLGGTNFRV +RV G ++ S+ Y +IP + G+ +LFD I + F + Sbjct: 64 LDLGGTNFRVLLVRVTTG---VQITSEIY---SIPETVAQGSGQQLFDHIVDCIVDFQQK 117 Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM-E 224 +G G+ LGFTFSFP Q + G L+ WTKGF + G+DVV+ L A+ Sbjct: 118 QG-----LSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITR 172 Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284 RQ +++ V A+VNDTVGT+ Y D +I+GTGTNA Y+E + G+ S Sbjct: 173 RQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNV---AGVPGDS 229 Query: 285 GNMVINMEWGNFK---SERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341 G M INMEWG F S + + +D ++D S+NPG+Q +EKMISGMYLGEIVR ILL Sbjct: 230 GRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLH 289 Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401 L LF +L+ R I +T +S + D S L+ + A L+D LG+ TS +A Sbjct: 290 LTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTSDDA-L 346 Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461 + L VC V++R A+L AG+ +++K+ +R G ++ + +DG LY+ + +F + Sbjct: 347 MVLEVCQAVSQRAAQLCGAGVAAVVEKIRENR----GLEELAVSVGVDGTLYKLHPRFSS 402 Query: 462 CLEATLADLLGEEAASSVVVKL-ANDGSGIGAALLAASHSQYASV 505 + AT+ +L A VV L + DGSG GAAL+ A + A + Sbjct: 403 LVAATVREL----APRCVVTFLQSEDGSGKGAALVTAVACRLAQL 443 >3W0L-A nrPDB Length = 458 Score = 251 bits (641), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 167/459 (36%), Positives = 249/459 (54%), Gaps = 30/459 (6%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGL--RADPHAPLKMLISYVDNLPTGDEHGLFY 106 ++++ F L + M EMERGL + A +KML +YV + P G E G F Sbjct: 9 VDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFL 68 Query: 107 ALDLGGTNFRVIRVQLG----GREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESF 162 ALDLGGTNFRV+ V++G G+ K V +++ +IP M GT+ LFD+IA + + Sbjct: 69 ALDLGGTNFRVMLVKVGEDLEGQWK--VETKHKMYSIPVDAMTGTAEMLFDYIAECISDY 126 Query: 163 VKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRA 222 + + + ++ LGFTFSFPV I G L+ WTKGF +G G +VV L A Sbjct: 127 LDQQN-----MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDA 181 Query: 223 MERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL 281 ++R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E + + G Sbjct: 182 IKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEG-- 239 Query: 282 PRSGNMVINMEWGNF-KSERLP--RSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 338 G M +N EWG F + L R +YD +D SLNPG+Q+YEKMI G Y+GE+VR + Sbjct: 240 -EEGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLV 298 Query: 339 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 398 L+K+ ++ LFG KL+ R T +S + DTS D K L+ LGV T + Sbjct: 299 LIKMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILR-TLGVQATIGD 356 Query: 399 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 458 + L C+ V+ R A + +AG+ GIL ++ + R + R + +DG +Y+ + Sbjct: 357 CHAVRL-ACESVSTRAAIMCSAGLAGILNRMRQSR----REELLRITVGVDGSVYKLHPS 411 Query: 459 FRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497 F+ AT+ L + + + +GSG GAAL++A Sbjct: 412 FKDKFHATVLKLT---SGCEITFIQSEEGSGRGAALISA 447 >1IG8-A nrPDB Length = 486 Score = 247 bits (630), Expect = 9e-66, Method: Compositional matrix adjust. Identities = 153/439 (34%), Positives = 227/439 (51%), Gaps = 30/439 (6%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108 IE E+ F+ PT L+ + + E+E+GL + + M+ +V + PTG E G F A+ Sbjct: 27 IENFEKIFTVPTETLQAVTKHFISELEKGL-SKKGGNIPMIPGWVMDFPTGKESGDFLAI 85 Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 166 DLGGTN RV+ V+LGG +Q + P M T EL++FIA L++F+ Sbjct: 86 DLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQNPDELWEFIADSLKAFI--- 139 Query: 167 GEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224 D P+G LGFTFSFP Q I+ G L +WTKGF I DVV L + + Sbjct: 140 --DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL--- 281 ++ + ++V AL+NDT GTL Y D + VI GTG N AY + + I K G L Sbjct: 198 KRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 Query: 282 -PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 338 P S M IN E+G+F +E LPR+ YD +D ES PG+Q +EKM SG YLGEI+R Sbjct: 258 IPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLA 317 Query: 339 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 398 L+ + +F + +K ++ F++ T + + D +L+ ++ G+ +T+++ Sbjct: 318 LMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI-NTTVQ 376 Query: 399 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 458 R + + +L+ R ARL+ GI I +K G + IA DG +Y Y Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGY----------KTGHIAADGSVYNRYPG 426 Query: 459 FRTCLEATLADLLGEEAAS 477 F+ L D+ G S Sbjct: 427 FKEKAANALKDIYGWTQTS 445 >4DCH-A nrPDB Length = 473 Score = 238 bits (607), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 167/478 (34%), Positives = 254/478 (53%), Gaps = 29/478 (6%) Query: 39 EERRRRAAAVIEEVEQ---RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYV 93 ++R R AA E+VEQ F L+ + M +EM+RGLR + H A +KML +YV Sbjct: 3 DDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYV 62 Query: 94 DNLPTGDEHGLFYALDLGGTNFRVIRVQLGGRE--KRVVSQQYEEVAIPPHLMVGTSMEL 151 + P G E G F +LDLGGTNFRV+ V++G E + V +++ +IP M GT+ L Sbjct: 63 RSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML 122 Query: 152 FDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTV 211 FD+I+ + F+ D H + ++ LGFTFSFPV I G L+ WTKGF +G Sbjct: 123 FDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAE 177 Query: 212 GEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEH 270 G +VV L A++R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E Sbjct: 178 GNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEE 237 Query: 271 ANAIPKWTGLLPRSGNMVINMEWGNF-KSERLPRS--DYDNALDFESLNPGEQIYEKMIS 327 + G G M +N EWG F S L +YD +D S NPG+Q+YEK+I Sbjct: 238 MQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIG 294 Query: 328 GMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLK 387 G Y+GE+VR +LL+L + LF +L R T +S + DT D K + + Sbjct: 295 GKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQI-YNIL 352 Query: 388 DILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIA 447 LG+ ++ + I C+ V+ R A + +AG+ G++ ++ R R + Sbjct: 353 STLGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVG 407 Query: 448 LDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505 +DG +Y+ + F+ A++ L + + + +GSG GAAL++A + A + Sbjct: 408 VDGSVYKLHPSFKERFHASVRRLT---PSCEITFIESEEGSGRGAALVSAVACKKACM 462 >3B8A-X nrPDB Length = 485 Score = 234 bits (596), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 163/460 (35%), Positives = 240/460 (52%), Gaps = 29/460 (6%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108 I ++E F+ + LR + ++E+ +GL + M+ +V PTG E G + A+ Sbjct: 27 IHQLEDMFTVDSETLRKVVKHFIDELNKGLTKK-GGNIPMIPGWVMEFPTGKESGNYLAI 85 Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 166 DLGGTN RV+ V+L G +Q ++ PH M T EL+ FIA L+ F+ E Sbjct: 86 DLGGTNLRVVLVKLSGNHTFDTTQSKYKL---PHDMRTTKHQEELWSFIADSLKDFM-VE 141 Query: 167 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226 E + + LGFTFS+P Q I+ G L +WTKGF I G DVV L + ++ Sbjct: 142 QELLNTKD--TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR 199 Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL----P 282 L +++ AL+NDTVGTL Y D + VI GTG N A+ + + I K G L P Sbjct: 200 ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIP 259 Query: 283 RSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 + M IN E+G+F +E LPR+ YD A+D +S PG+Q +EKM SG YLGE++R +LL Sbjct: 260 SNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLL 319 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 +L + D +KL+Q +I+ T + + D +L+ + GV T+L R Sbjct: 320 ELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVK-TTLPER 378 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 + +C+L+ R ARLA GI I +K G + IA DG +Y Y F+ Sbjct: 379 KLIRRLCELIGTRAARLAVCGIAAICQKRGY----------KTGHIAADGSVYNKYPGFK 428 Query: 461 TCLEATLADLL---GEEAASSVVVKLANDGSGIGAALLAA 497 L D+ G+ + + + A DGSG GAA++AA Sbjct: 429 EAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAA 468 >2YHX-A nrPDB Length = 457 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 22/218 (10%) Query: 56 FSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNF 115 F P +L+ + + + + P M+ +V +G + G F A+ +GG + Sbjct: 16 FIVPPXILQAVVSILTTRXDDXDSSAASIP--MVPGWVLKQVSGAQAGSFLAIVMGGGDL 73 Query: 116 RVIRVQLGGREK------RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGED 169 VI + L GR++ R ++ AIP L + + S + Sbjct: 74 EVILISLAGRQESSIXASRSLAAAMSTTAIPSDLWGNXAX------SNAAFSSXEFSSXA 127 Query: 170 FHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQGLD 229 +P LGFTF + + G + FS+ +++ + A G Sbjct: 128 GSVP------LGFTFXEAGAKEXVIKGQITXQAXAFSLAXL--XKLISAMXNAXFPAGDX 179 Query: 230 MKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAY 267 A + D+ G L Y D + +I G+G NAAY Sbjct: 180 XXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 >1HKG-A nrPDB Length = 457 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 20/188 (10%) Query: 86 LKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREK------RVVSQQYEEVAI 139 + M+ +V G + G F A+ +GG + VI + L G ++ R ++ AI Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 140 PPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLI 199 P L + + S + +P LGFTF + + G + Sbjct: 104 PSDLWGNXAX------SNAAFSSXEFSSXAGSVP------LGFTFXEAGAKEXVIKGQIT 151 Query: 200 KWTKGFSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVIL 259 FS+ +++ + A G A + D+ G L Y D + +I Sbjct: 152 XQAXAFSLAXL--XKLISAMXNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIF 209 Query: 260 GTGTNAAY 267 G+G NAAY Sbjct: 210 GSGVNAAY 217 >4OVD-A nrPDB Length = 564 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 11/66 (16%) Query: 298 SERLPRSDYDNALDFESLNPGEQIYEKMISGMY-LGEIVRRILLKLAHDASLFGD----V 352 S LP + DN +D+ESLN K++S +Y G + + I + D +LFG Sbjct: 265 SYPLPDFESDNGVDYESLN------LKLVSSIYEPGSVFKVITTSIGVDNNLFGPNSTFN 318 Query: 353 VPTKLE 358 +PT+L+ Sbjct: 319 IPTELQ 324 >5ZEP-H nrPDB Length = 151 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 29/47 (61%), Gaps = 3/47 (6%) Query: 22 GVAVVVSRRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIAD 68 G+A+V SR ++R+AEE RR R + VI ++E TA L G+ D Sbjct: 34 GLAIVASRG--AERQAEEIRRARESKVIRDIEHANELKTA-LEGLGD 77 >2IZO-A nrPDB Length = 346 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 22/55 (40%), Positives = 38/55 (69%), Gaps = 5/55 (9%) Query: 27 VSRRRRSKREAEEE-RRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRA 80 + RRR++K EAE + R ++ IEE+ +++S A+LR +++ MVEE ++ LRA Sbjct: 88 LERRRKAKEEAERKLERAKSEGKIEEL-RKYSQ--AILR-LSNIMVEESKKLLRA 138 >4B2T-A nrPDB Length = 556 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 8/107 (7%) Query: 57 STPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFR 116 ++ + +LRG D M +EMER L D +K ++ +P G + AL + N+ Sbjct: 371 TSASVILRGANDFMCDEMERSLH-DALCVVKRVLESKSVVPGG--GAVEAALSIYLENY- 426 Query: 117 VIRVQLGGREKRVVSQQYEEV-AIPPHLMVGTSMELFDFIAAELESF 162 +G RE+ +++ + IP L V + + D + A+L +F Sbjct: 427 --ATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLV-AKLRAF 470 >6FPX-A nrPDB Length = 192 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 4/52 (7%) Query: 382 LGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDR 433 A++ +I+ D EAR +++ + G+RL Y I+K++GRDR Sbjct: 145 FSAEISEIVSHMDHGSEAR----DGMEMMYDEGSRLCTLINYAIMKRIGRDR 192 >6D7W-A nrPDB Length = 416 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 12/22 (54%), Positives = 15/22 (68%) Query: 405 HVCDLVAERGARLAAAGIYGIL 426 H CD +A RGA+ A G +GIL Sbjct: 257 HECDALAHRGAQRVALGGFGIL 278 >5HFZ-A nrPDB Length = 170 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 4/52 (7%) Query: 382 LGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDR 433 A++ +I+ D EAR +++ + G+RL Y I+K++GRDR Sbjct: 123 FSAEISEIVSHMDHGSEAR----DGMEMMYDEGSRLCTLINYAIMKRIGRDR 170 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5ZQT-A nrPDB 644 0.0 1BG3-A nrPDB 627 e-180 4FOI-A nrPDB 627 e-180 4QS9-A nrPDB 608 e-174 5HFU-A nrPDB 593 e-170 3O1W-A nrPDB 584 e-167 3W0L-A nrPDB 584 e-167 4DCH-A nrPDB 576 e-165 3HM8-A nrPDB 568 e-162 1IG8-A nrPDB 567 e-162 3B8A-X nrPDB 558 e-159 1BDG-A nrPDB 548 e-156 Sequences not found previously or not previously below threshold: 2YHX-A nrPDB 139 3e-33 1HKG-A nrPDB 135 6e-32 1Q1R-A nrPDB 29 4.9 1E19-A nrPDB 29 6.0 6MU0-A nrPDB 29 6.1 2WD5-A nrPDB 28 7.9 2BWY-A nrPDB 28 8.0 1Q5D-A nrPDB 28 9.7 >5ZQT-A nrPDB Length = 473 Score = 644 bits (1661), Expect = 0.0, Method: Composition-based stats. Identities = 463/466 (99%), Positives = 463/466 (99%) Query: 41 RRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD 100 R AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD Sbjct: 8 RIPMAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD 67 Query: 101 EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE 160 EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE Sbjct: 68 EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE 127 Query: 161 SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 220 SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS Sbjct: 128 SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 187 Query: 221 RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL 280 RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL Sbjct: 188 RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL 247 Query: 281 LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL Sbjct: 248 LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 307 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR Sbjct: 308 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 367 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR Sbjct: 368 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 427 Query: 461 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 506 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE Sbjct: 428 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 473 >1BG3-A nrPDB Length = 918 Score = 627 bits (1618), Expect = e-180, Method: Composition-based stats. Identities = 177/474 (37%), Positives = 253/474 (53%), Gaps = 30/474 (6%) Query: 35 REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92 R AE+ R+ IEE F L + + EME GLR + + A +KML S+ Sbjct: 462 RLAEQHRQ------IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSF 515 Query: 93 VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152 V ++P G EHG F ALDLGGTNFRV+ V++ +KR V + +IP +M GT ELF Sbjct: 516 VRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELF 575 Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212 D I + + F+ D+ +G + LGFTFSFP HQT++ G LI WTKGF G Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEG 630 Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271 DV + L A++R+ D+ V A+VNDTVGT+ Y + +I+GTGTNA Y+E Sbjct: 631 HDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEM 690 Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328 + G G M INMEWG F R+D+D +D SLN G+Q +EKMISG Sbjct: 691 KNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISG 747 Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388 MYLGEIVR IL+ LF + L+ R I T +S + D L + A L+ Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806 Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448 LG+ +++ + + VC +V++R A+L AG+ +++K+ +R G + + Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGV 860 Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502 DG LY+ + F + T+ +L +V L+ DGSG GAAL+ A + Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITAVGVRL 911 Score = 494 bits (1271), Expect = e-140, Method: Composition-based stats. Identities = 163/463 (35%), Positives = 249/463 (53%), Gaps = 24/463 (5%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLF 105 I++ +L I +EM+ GL D P A +KML ++V ++P G E G F Sbjct: 21 KIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF 80 Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165 ALDLGG++FR++RVQ+ + + VS + E P +++ G+ +LFD +A L F++ Sbjct: 81 IALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEK 140 Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225 + +GFTFSFP Q+ I LI WTK F +G G DVV L++A+++ Sbjct: 141 KKIKDKK-----LPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284 +G D + A+VNDTVGT+ Y D +I+GTGTNA Y+E I G Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252 Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341 G M IN EWG F + R+++D LD SLNPG+Q++EKM+SGMY+GE+VR IL+K Sbjct: 253 GRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 312 Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401 +A + LF + +L R T D+SA+ D +++ L LGV + ++ Sbjct: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEILTR-LGVEPSDVDC-V 369 Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461 H+C +V+ R A L AA + IL +L ++ G+ + RT + +DG LY+ + ++ Sbjct: 370 SVQHICTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVDGSLYKMHPQYSR 425 Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYAS 504 TL L+ S V L+ G+G GAA++ A + A Sbjct: 426 RFHKTLRRLV---PDSDVRFLLSESGTGKGAAMVTAVAYRLAE 465 >4FOI-A nrPDB Length = 917 Score = 627 bits (1617), Expect = e-180, Method: Composition-based stats. Identities = 181/474 (38%), Positives = 250/474 (52%), Gaps = 30/474 (6%) Query: 35 REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92 R AE+ R+ IEE F +L + M EME GLR H A +KML S+ Sbjct: 462 RLAEQHRQ------IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSF 515 Query: 93 VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152 V P G E+G F ALDLGGTNFRV+ V++ +KR V + AIP +M GT ELF Sbjct: 516 VRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF 575 Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212 D I + + F+ D+ +G + LGFTFSFP QTS+ +G LI WTKGF VG Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVG 630 Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271 DVV L A++R+ D+ V A+VNDTVGT+ Y + +I+GTG+NA Y+E Sbjct: 631 HDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEM 690 Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328 + G G M INMEWG F R+ YD +D SLN G+Q YEKMISG Sbjct: 691 KNVEMVEG---DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISG 747 Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388 MYLGEIVR IL+ LF + L+ R I T +S + D L + A L+ Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806 Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448 LG+ +++ + + VC +V+ R A+L AG+ ++ K+ +R G + + + Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGV 860 Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502 DG LY+ + F + T+ +L +V L+ DGSG GAAL+ A + Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCNVSFLLSEDGSGKGAALITAVGVRL 911 Score = 498 bits (1282), Expect = e-141, Method: Composition-based stats. Identities = 164/463 (35%), Positives = 247/463 (53%), Gaps = 24/463 (5%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLF 105 I++ L I +EM+ GL D P A +KML ++V ++P G E G F Sbjct: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80 Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165 ALDLGG++FR++RVQ+ + + V + E P +++ G+ +LFD +A L F++ Sbjct: 81 IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 140 Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225 + ++ +GFTFSFP Q+ I LI WTK F +G G DVV L++A+++ Sbjct: 141 RK-----IKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284 +G D + A+VNDTVGT+ Y D +I+GTGTNA Y+E I G Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252 Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341 G M IN EWG F + R+++D +D SLNPG+Q++EKM+SGMYLGE+VR IL+K Sbjct: 253 GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK 312 Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401 +A + LF + +L R T D+SA+ + L + L LGV S + Sbjct: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEILTR-LGVE-PSDDDCV 369 Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461 HVC +V+ R A L AA + IL +L ++ G+ + RT + ++G LY+ + ++ Sbjct: 370 SVQHVCTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVNGSLYKTHPQYSR 425 Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYAS 504 TL L+ S V L+ GSG GAA++ A + A Sbjct: 426 RFHKTLRRLV---PDSDVRFLLSESGSGKGAAMVTAVAYRLAE 465 >4QS9-A nrPDB Length = 474 Score = 608 bits (1567), Expect = e-174, Method: Composition-based stats. Identities = 310/459 (67%), Positives = 376/459 (81%), Gaps = 2/459 (0%) Query: 44 RAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHG 103 R A+++ E+ +TP + LR +ADAM EM GL +D + LKMLISYVDNLP+GDE G Sbjct: 14 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKG 73 Query: 104 LFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV 163 LFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA L FV Sbjct: 74 LFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV 133 Query: 164 KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM 223 TE EDFHLPEGRQRELGFTF+FPV QTS+SSG+LIKWTKGFSI VG+DVV L++A+ Sbjct: 134 ATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKAL 193 Query: 224 ERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283 ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW GLLP+ Sbjct: 194 ERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPK 253 Query: 284 SGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343 SG MVINMEWGNF+S LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+LLK+A Sbjct: 254 SGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMA 313 Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403 DA+ FGD VP+KL FI+RTP MSAMH+DTS DLK +G+K+KDIL V TSL+ R + Sbjct: 314 EDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVV 373 Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463 + +C+++A RGARL+AAGIYGILKKLGRD + Q++VIA+DGGL+EHY +F C+ Sbjct: 374 ISLCNIIATRGARLSAAGIYGILKKLGRDTTKD--EEVQKSVIAMDGGLFEHYTQFSECM 431 Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502 E++L +LLG+EA+ SV V +NDGSGIGAALLAASHS Y Sbjct: 432 ESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 470 >5HFU-A nrPDB Length = 923 Score = 593 bits (1528), Expect = e-170, Method: Composition-based stats. Identities = 173/473 (36%), Positives = 244/473 (51%), Gaps = 30/473 (6%) Query: 35 REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAP--LKMLISY 92 R A++ R R ++ + L + M EMERGL + HA +KML +Y Sbjct: 468 RLADQHRAR------QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTY 521 Query: 93 VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152 V P G E G F ALDLGGTNFRV+ V++ + V + AIP +M GT ELF Sbjct: 522 VCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELF 581 Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212 D I + F++ + +G LGFTFSFP Q S+ L+KWTKGF +G G Sbjct: 582 DHIVQCIADFLE-----YMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEG 636 Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271 EDVV L A+ R+ D+ V A+VNDTVGT+ + D +I+GTG+NA Y+E Sbjct: 637 EDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEM 696 Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERLP---RSDYDNALDFESLNPGEQIYEKMISG 328 + G G M +NMEWG F R+++D A+D SLNPG+Q +EKMISG Sbjct: 697 RNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 753 Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388 MYLGEIVR IL+ LF + +L+ R I T +S + D L + A L+ Sbjct: 754 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA-LLQVRAILQH 812 Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448 LG+ ++ + I VC +VA R A+L AG+ ++ ++ +R G + + + Sbjct: 813 -LGLE-STCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENR----GLDALKVTVGV 866 Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501 DG LY+ + F + T+ DL V + DGSG GAAL+ A + Sbjct: 867 DGTLYKLHPHFAKVMHETVKDL---APKCDVSFLQSEDGSGKGAALITAVACR 916 Score = 584 bits (1505), Expect = e-167, Method: Composition-based stats. Identities = 168/462 (36%), Positives = 255/462 (55%), Gaps = 24/462 (5%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLF 105 +++ L I+ +EME+GL A H A +KML ++V + P G EHG F Sbjct: 27 KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 86 Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165 ALDLGGTNFRV+ V++ + V + + AIP +M G+ +LFD IA L +F+ Sbjct: 87 LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFM-- 144 Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225 D + ++ LGFTFSFP HQT + L+ WTKGF +G G DVVA + +A++R Sbjct: 145 ---DKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 201 Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284 +G D+ + A+VNDTVGT+ Y D++ +I+GTG+NA Y+E I G Sbjct: 202 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DE 258 Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341 G M INMEWG F + R+++D +D SLNPG+Q++EKMISGMY+GE+VR IL+K Sbjct: 259 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 318 Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401 +A + LFG + +L T D+S + + K ++ LG+ D + E Sbjct: 319 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPTQEDCV 375 Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461 T +C +V+ R A L AA + +L+++ ++ G ++ R+ I +DG +Y+ + F Sbjct: 376 ATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKHPHFAK 431 Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYA 503 L T+ L+ V + DGSG GAA++ A + A Sbjct: 432 RLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTAVAYRLA 470 >3O1W-A nrPDB Length = 485 Score = 584 bits (1506), Expect = e-167, Method: Composition-based stats. Identities = 167/461 (36%), Positives = 237/461 (51%), Gaps = 31/461 (6%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108 I +E F+ + +R I + E+++GL + + M+ +V PTG E G F AL Sbjct: 27 IHGLETLFTVSSEKMRSIVKHFISELDKGL-SKKGGNIPMIPGWVVEYPTGKETGDFLAL 85 Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGE 168 DLGGTN RV+ V+LGG +Q + +P HL GTS +L+ FIA L+ FV Sbjct: 86 DLGGTNLRVVLVKLGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV----- 138 Query: 169 DFHLPEGRQ--RELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226 D P+G LGFTFS+P Q I+SG L +WTKGF I G G DVV L +E+ Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198 Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR--- 283 + + V AL+NDT GTL Y D +I+GTG N AY + + I K GLLP Sbjct: 199 NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIG 258 Query: 284 -SGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 M IN E+G+F +E LPR+ YD +D ES PG+Q +EKM SG YLGEI+R +LL Sbjct: 259 PDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLL 318 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 L +F D +KL++ +++ T S + D +L+ K L + T +E R Sbjct: 319 DLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE-R 377 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 + + +LV R ARL G+ I K G + IA DG ++ Y ++ Sbjct: 378 KLIRKLAELVGTRAARLTVCGVSAICDKRGY----------KTAHIAADGSVFNRYPGYK 427 Query: 461 TCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 497 L D+ + + + A DGSG+GAA++A Sbjct: 428 EKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIAC 468 >3W0L-A nrPDB Length = 458 Score = 584 bits (1505), Expect = e-167, Method: Composition-based stats. Identities = 165/465 (35%), Positives = 248/465 (53%), Gaps = 26/465 (5%) Query: 49 IEEVEQRFSTPTALLRGIADAMVEEMERGL--RADPHAPLKMLISYVDNLPTGDEHGLFY 106 ++++ F L + M EMERGL + A +KML +YV + P G E G F Sbjct: 9 VDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFL 68 Query: 107 ALDLGGTNFRVIRVQLGGR--EKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 164 ALDLGGTNFRV+ V++G + V +++ +IP M GT+ LFD+IA + ++ Sbjct: 69 ALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYLD 128 Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224 + + ++ LGFTFSFPV I G L+ WTKGF +G G +VV L A++ Sbjct: 129 QQN-----MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 183 Query: 225 RQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283 R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E + + G Sbjct: 184 RRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEG---E 240 Query: 284 SGNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 G M +N EWG F R +YD +D SLNPG+Q+YEKMI G Y+GE+VR +L+ Sbjct: 241 EGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLI 300 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 K+ ++ LFG KL+ R T +S + DTS D K L+ LGV T + Sbjct: 301 KMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILR-TLGVQATIGDCH 358 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 + L C+ V+ R A + +AG+ GIL ++ + R + R + +DG +Y+ + F+ Sbjct: 359 AVRL-ACESVSTRAAIMCSAGLAGILNRMRQSR----REELLRITVGVDGSVYKLHPSFK 413 Query: 461 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505 AT+ L + + + +GSG GAAL++A + A + Sbjct: 414 DKFHATVLKLT---SGCEITFIQSEEGSGRGAALISAVAYKMAVM 455 >4DCH-A nrPDB Length = 473 Score = 576 bits (1484), Expect = e-165, Method: Composition-based stats. Identities = 162/478 (33%), Positives = 250/478 (52%), Gaps = 29/478 (6%) Query: 39 EERRRRAAAV---IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYV 93 ++R R AA +E++ F L+ + M +EM+RGLR + H A +KML +YV Sbjct: 3 DDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYV 62 Query: 94 DNLPTGDEHGLFYALDLGGTNFRVIRVQLGGR--EKRVVSQQYEEVAIPPHLMVGTSMEL 151 + P G E G F +LDLGGTNFRV+ V++G + V +++ +IP M GT+ L Sbjct: 63 RSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML 122 Query: 152 FDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTV 211 FD+I+ + F+ D H + ++ LGFTFSFPV I G L+ WTKGF +G Sbjct: 123 FDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAE 177 Query: 212 GEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEH 270 G +VV L A++R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E Sbjct: 178 GNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEE 237 Query: 271 ANAIPKWTGLLPRSGNMVINMEWGNFKSERLP---RSDYDNALDFESLNPGEQIYEKMIS 327 + G G M +N EWG F +YD +D S NPG+Q+YEK+I Sbjct: 238 MQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIG 294 Query: 328 GMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLK 387 G Y+GE+VR +LL+L + LF +L R T +S + DT D K + L Sbjct: 295 GKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNIL- 352 Query: 388 DILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIA 447 LG+ ++ + I C+ V+ R A + +AG+ G++ ++ R R + Sbjct: 353 STLGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVG 407 Query: 448 LDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505 +DG +Y+ + F+ A++ L + + + +GSG GAAL++A + A + Sbjct: 408 VDGSVYKLHPSFKERFHASVRRLT---PSCEITFIESEEGSGRGAALVSAVACKKACM 462 >3HM8-A nrPDB Length = 445 Score = 568 bits (1464), Expect = e-162, Method: Composition-based stats. Identities = 169/462 (36%), Positives = 251/462 (54%), Gaps = 27/462 (5%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYA 107 ++EE F L + M + M +GLR + + L+ML ++V P G E G F A Sbjct: 5 LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA-SSLRMLPTFVRATPDGSERGDFLA 63 Query: 108 LDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEG 167 LDLGGTNFRV+ V++ V E +IP + G+ +LFD I + F + +G Sbjct: 64 LDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQG 119 Query: 168 EDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ- 226 G+ LGFTFSFP Q + G L+ WTKGF + G+DVV+ L A+ R+ Sbjct: 120 -----LSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQ 174 Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGN 286 +++ V A+VNDTVGT+ Y D +I+GTGTNA Y+E + G+ SG Sbjct: 175 AVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNV---AGVPGDSGR 231 Query: 287 MVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343 M INMEWG F + + + +D ++D S+NPG+Q +EKMISGMYLGEIVR ILL L Sbjct: 232 MCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLT 291 Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403 LF +L+ R I +T +S + D S L+ + A L+D LG+ TS + + Sbjct: 292 SLGVLFRGQQIQRLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTS-DDALMV 348 Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463 L VC V++R A+L AG+ +++K+ +R G ++ + +DG LY+ + +F + + Sbjct: 349 LEVCQAVSQRAAQLCGAGVAAVVEKIRENR----GLEELAVSVGVDGTLYKLHPRFSSLV 404 Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505 AT+ +L V + DGSG GAAL+ A + A + Sbjct: 405 AATVREL---APRCVVTFLQSEDGSGKGAALVTAVACRLAQL 443 >1IG8-A nrPDB Length = 486 Score = 567 bits (1461), Expect = e-162, Method: Composition-based stats. Identities = 155/472 (32%), Positives = 240/472 (50%), Gaps = 34/472 (7%) Query: 29 RRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKM 88 ++ ++++ + + + IE E+ F+ PT L+ + + E+E+GL + + M Sbjct: 7 KKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGL-SKKGGNIPM 65 Query: 89 LISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS 148 + +V + PTG E G F A+DLGGTN RV+ V+LGG +Q + P M T Sbjct: 66 IPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQ 122 Query: 149 --MELFDFIAAELESFVKTEGEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKG 204 EL++FIA L++F+ D P+G LGFTFSFP Q I+ G L +WTKG Sbjct: 123 NPDELWEFIADSLKAFI-----DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKG 177 Query: 205 FSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTN 264 F I DVV L + + ++ + ++V AL+NDT GTL Y D + VI GTG N Sbjct: 178 FDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVN 237 Query: 265 AAYVEHANAIPKWTGLL----PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPG 318 AY + + I K G L P S M IN E+G+F +E LPR+ YD +D ES PG Sbjct: 238 GAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPG 297 Query: 319 EQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHD 378 +Q +EKM SG YLGEI+R L+ + +F + +K ++ F++ T + + D + Sbjct: 298 QQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFEN 357 Query: 379 LKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDG 438 L+ ++ G+ +T+++ R + + +L+ R ARL+ GI I +K G Sbjct: 358 LEDTDDLFQNEFGI-NTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGY------- 409 Query: 439 SQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAAS----SVVVKLAND 486 + IA DG +Y Y F+ L D+ G S + + A D Sbjct: 410 ---KTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAED 458 >3B8A-X nrPDB Length = 485 Score = 558 bits (1437), Expect = e-159, Method: Composition-based stats. Identities = 163/484 (33%), Positives = 249/484 (51%), Gaps = 29/484 (5%) Query: 29 RRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKM 88 ++ ++++ + + + I ++E F+ + LR + ++E+ +GL + M Sbjct: 7 KKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGL-TKKGGNIPM 65 Query: 89 LISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGT- 147 + +V PTG E G + A+DLGGTN RV+ V+L G +Q ++ PH M T Sbjct: 66 IPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKL---PHDMRTTK 122 Query: 148 -SMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFS 206 EL+ FIA L+ F+ E E + + LGFTFS+P Q I+ G L +WTKGF Sbjct: 123 HQEELWSFIADSLKDFM-VEQELLNTKD--TLPLGFTFSYPASQNKINEGILQRWTKGFD 179 Query: 207 INGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAA 266 I G DVV L + ++ L +++ AL+NDTVGTL Y D + VI GTG N A Sbjct: 180 IPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGA 239 Query: 267 YVEHANAIPKWTGLL----PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQ 320 + + + I K G L P + M IN E+G+F +E LPR+ YD A+D +S PG+Q Sbjct: 240 FYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQ 299 Query: 321 IYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLK 380 +EKM SG YLGE++R +LL+L + D +KL+Q +I+ T + + D +L+ Sbjct: 300 AFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLE 359 Query: 381 HLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQ 440 + GV T+L R + +C+L+ R ARLA GI I +K G Sbjct: 360 DTDDIFQKDFGVK-TTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGY--------- 409 Query: 441 KQRTVIALDGGLYEHYKKFRTCLEATLADLLGEE---AASSVVVKLANDGSGIGAALLAA 497 + IA DG +Y Y F+ L D+ G + + + A DGSG GAA++AA Sbjct: 410 -KTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAA 468 Query: 498 SHSQ 501 + Sbjct: 469 LSEK 472 >1BDG-A nrPDB Length = 451 Score = 548 bits (1413), Expect = e-156, Method: Composition-based stats. Identities = 166/459 (36%), Positives = 249/459 (54%), Gaps = 25/459 (5%) Query: 48 VIEEVEQRFSTPTALLRGIADAMVEEMERGLR--ADPHAPLKMLISYVDNLPTGDEHGLF 105 + E+ + F I D M E M GL+ + + +KM SYV P G E G F Sbjct: 11 KVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNF 70 Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165 ALDLGGTN+RV+ V L G+ K Q+ IP M G+ ELF +IA L F++ Sbjct: 71 LALDLGGTNYRVLSVTLEGKGKSPRIQE-RTYCIPAEKMSGSGTELFKYIAETLADFLEN 129 Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225 G + ++ +LGFTFSFP Q ++ TL++WTKGFS +G G +V L +++ Sbjct: 130 NG-----MKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDK 184 Query: 226 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 285 + L++K A+VNDTVGTLA D A +I+GTGTN AY+E ++ + G+ + Sbjct: 185 RELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV--KEP 242 Query: 286 NMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 342 +VIN EWG F + R+ +D ++D +SL+PG+Q+YEKM+SGMYLGE+VR I++ L Sbjct: 243 EVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYL 302 Query: 343 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 402 LF +P +L+ R L T ++ + D +H L + L D L V I Sbjct: 303 VEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRI 362 Query: 403 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 462 + C++V +R A LA AGI IL+++ R + +DG LY+ + KF Sbjct: 363 VRYACEMVVKRAAYLAGAGIACILRRINRSE----------VTVGVDGSLYKFHPKFCER 412 Query: 463 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501 + + L + + ++L+ DGSG GAA +AAS ++ Sbjct: 413 MTDMVDKL--KPKNTRFCLRLSEDGSGKGAAAIAASCTR 449 >2YHX-A nrPDB Length = 457 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 85/464 (18%), Positives = 152/464 (32%), Gaps = 36/464 (7%) Query: 47 AVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFY 106 +++E F P +L+ + + A + M+ +V +G + G F Sbjct: 7 SLVEVHXXVFIVPPXILQAVVSILTT--RXDDXDSSAASIPMVPGWVLKQVSGAQAGSFL 64 Query: 107 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS--MELFDFIAAELESFVK 164 A+ +GG + VI + L GR++ + A M T+ +L+ A Sbjct: 65 AIVMGGGDLEVILISLAGRQESSIXASRSLAA----AMSTTAIPSDLWGNXAXS----NA 116 Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224 LGFTF + + G + FS+ +++ + A Sbjct: 117 AFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLX--KLISAMXNAXF 174 Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAI--PKWTGLLP 282 G A + D+ G L Y D + +I G+G NAAY + I G Sbjct: 175 PAGDXXXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIGDAADGGXXG 234 Query: 283 RSGNMVINMEWGNFKSE--RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340 +G M I + +F+ LP+ Y L+ S + + K G+ +R +L+ Sbjct: 235 GAGXMXICCDQSSFRKAFPSLPQIXYLXTLNXXSPXAXK-TFXKNSXAKNXGQSLRDVLM 293 Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400 + T + + DL+ G+A + + Sbjct: 294 XFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTX-MK 351 Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460 + L+A RL I I +K G IA G Y F Sbjct: 352 XVVRRXLFLIAAYAFRLVVCXIXAICQKKGYS----------SGHIAAXGSX-RSYSGFS 400 Query: 461 TCLEATLADLLGEEA----ASSVVVKLANDGSGIGAALLAASHS 500 ++ G + + + A DG G + ++ + S Sbjct: 401 XNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIAS 444 >1HKG-A nrPDB Length = 457 Score = 135 bits (339), Expect = 6e-32, Method: Composition-based stats. Identities = 83/469 (17%), Positives = 149/469 (31%), Gaps = 36/469 (7%) Query: 42 RRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDE 101 +++E F P +L+ + + A + M+ +V G + Sbjct: 2 ASXDXSLVEVHXXVFIVPPXILQAVVS--IATTRXDDXDSAAASIPMVPGWVLKQVXGSQ 59 Query: 102 HGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS--MELFDFIAAEL 159 G F A+ +GG + VI + L G ++ + A M T+ +L+ A Sbjct: 60 AGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA----SMXTTAIPSDLWGNXAXS- 114 Query: 160 ESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAEL 219 LGFTF + + G + FS+ +++ + Sbjct: 115 ---NAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLX--KLISAM 169 Query: 220 SRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAI--PKW 277 A G A + D+ G L Y D + +I G+G NAAY + I Sbjct: 170 XNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIADAAD 229 Query: 278 TGLLPRSGNMVINMEWGNFKSE--RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIV 335 G +G M + +F+ LP+ Y L+ S + +EK G+ + Sbjct: 230 AGXXGGAGXMXVCCXQDSFRKAFPSLPQIXYXXTLNXXSPXAXK-TFEKNSXAKNXGQSL 288 Query: 336 RRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADT 395 R +L+ + + + + DL+ G+A Sbjct: 289 RDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXK 347 Query: 396 SLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEH 455 + + + L+A RL I I +K G IA G Sbjct: 348 TX-MKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYS----------SGHIAAXGSX-RD 395 Query: 456 YKKFRTCLEATLADLLGEEA----ASSVVVKLANDGSGIGAALLAASHS 500 Y F ++ G + + + A DG G ++ + S Sbjct: 396 YSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIAS 444 >1Q1R-A nrPDB Length = 431 Score = 28.8 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 14/42 (33%) Query: 244 AGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 285 Y A V + TGT E + K T +L G Sbjct: 193 VSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDG 234 >1E19-A nrPDB Length = 314 Score = 28.8 bits (63), Expect = 6.0, Method: Composition-based stats. Identities = 19/146 (13%), Positives = 45/146 (30%), Gaps = 20/146 (13%) Query: 116 RVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEG 175 RV+ + LGG + Q+ + ++ IA + + + P+ Sbjct: 4 RVV-IALGGNALQQRGQKGSYEEMMDNVRKTARQ-----IAEIIARGYEVVITHGNGPQV 57 Query: 176 RQRELGF-----TFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQGLDM 230 L T+ P ++ W +G + L + ++G++ Sbjct: 58 GSLLLHMDAGQATYGIPAQPMDVAGAMSQGW---------IGYMIQQALKNELRKRGMEK 108 Query: 231 KVTALVNDTVGTLAGGRYVDNDVAAA 256 KV ++ T+ + + Sbjct: 109 KVVTIITQTIVDKNDPAFQNPTKPVG 134 >6MU0-A nrPDB Length = 160 Score = 28.8 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 27/72 (37%), Gaps = 4/72 (5%) Query: 6 VVGTAVVVCAAAAAAVGVAVVVSRRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRG 65 + GT V VC AA GV + ++ A + + RF T + ++ Sbjct: 76 ICGTGVGVCMAANKVKGVLAALVVSEKTAALARQHDNANVLC----LSSRFVTDSENIKI 131 Query: 66 IADAMVEEMERG 77 + D + E G Sbjct: 132 VDDFLKANFEGG 143 >2WD5-A nrPDB Length = 233 Score = 28.5 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 57/154 (37%), Gaps = 17/154 (11%) Query: 302 PRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRF 361 P S Y +D P ++ Y+ ++ LG+ + I++ D + EQR Sbjct: 52 PGSVYGRLIDL--CQPTQKKYQIAVT-KVLGKNMDAIIVDSEKTG---RDCIQYIKEQRG 105 Query: 362 ILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAG 421 T ++K KL+++ G RY H+ + A A G Sbjct: 106 EPETFLPLD-----YLEVKPTDEKLRELKGAKLVIDVIRYEPPHI------KKALQYACG 154 Query: 422 IYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEH 455 + + R + G ++ +ALDG L++ Sbjct: 155 NALVCDNVEDARRIAFGGHQRHKTVALDGTLFQK 188 >2BWY-A nrPDB Length = 440 Score = 28.5 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 41/116 (35%), Gaps = 31/116 (26%) Query: 258 ILGTGTNAAYVEHANA-IPKWTG--LLPRSGNMVINMEWGNFKSE------------RLP 302 I+G+G N + + G +L +G E+ + + + Sbjct: 232 IVGSGENGCILHYTENECEMRDGDLVLIDAG-----CEYKGYAGDITRTFPVNGKFTQAQ 286 Query: 303 RSDYDNALD--FESLN---PGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVV 353 R YD L+ SL PG I E GE+VR ++ L L GDV Sbjct: 287 REIYDIVLESLETSLRLYRPGTSILE------VTGEVVRIMVSGLVKLGILKGDVD 336 >1Q5D-A nrPDB Length = 419 Score = 28.1 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 59/178 (33%), Gaps = 16/178 (8%) Query: 202 TKGFSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGT 261 TK + T G ++ + R L+ V ++ + + I+ Sbjct: 195 TKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAA 254 Query: 262 GTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQI 321 GT+ A A+ L ++ E G ++ +DN L ++ Q Sbjct: 255 GTDTTIYLIAFAVLNL--LRSPEALELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQD 312 Query: 322 YEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDL 379 E + + GE+V ++ P+ L + PD+ + DTS L Sbjct: 313 LEYCGASIKKGEMVFLLI--------------PSALRDGTVFSRPDVFDVRRDTSASL 356 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.316 0.137 0.370 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,971,226 Number of Sequences: 36641 Number of extensions: 791088 Number of successful extensions: 2499 Number of sequences better than 10.0: 23 Number of HSP's better than 10.0 without gapping: 35 Number of HSP's successfully gapped in prelim test: 17 Number of HSP's that attempted gapping in prelim test: 2261 Number of HSP's gapped (non-prelim): 63 length of query: 506 length of database: 10,336,785 effective HSP length: 101 effective length of query: 405 effective length of database: 6,636,044 effective search space: 2687597820 effective search space used: 2687597820 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 61 (28.1 bits)