BLASTP 2.2.23 [Feb-03-2010]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= Q8LQ68
         (506 letters)

Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 
           36,641 sequences; 10,336,785 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

5ZQT-A nrPDB                                                          947   0.0  
4QS9-A nrPDB                                                          647   0.0  
1BDG-A nrPDB                                                          274   6e-74
5HFU-A nrPDB                                                          273   2e-73
4FOI-A nrPDB                                                          271   4e-73
1BG3-A nrPDB                                                          271   5e-73
3O1W-A nrPDB                                                          265   4e-71
3HM8-A nrPDB                                                          258   3e-69
3W0L-A nrPDB                                                          251   5e-67
1IG8-A nrPDB                                                          247   9e-66
4DCH-A nrPDB                                                          238   5e-63
3B8A-X nrPDB                                                          234   8e-62
2YHX-A nrPDB                                                           39   0.004
1HKG-A nrPDB                                                           36   0.031
4OVD-A nrPDB                                                           33   0.20 
5ZEP-H nrPDB                                                           30   2.0  
2IZO-A nrPDB                                                           29   4.0  
4B2T-A nrPDB                                                           29   5.0  
6FPX-A nrPDB                                                           29   5.4  
6D7W-A nrPDB                                                           29   6.2  
5HFZ-A nrPDB                                                           29   6.2  

>5ZQT-A nrPDB
          Length = 473

 Score =  947 bits (2449), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 462/462 (100%), Positives = 462/462 (100%)

Query: 45  AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL 104
           AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL
Sbjct: 12  AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGL 71

Query: 105 FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 164
           FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK
Sbjct: 72  FYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 131

Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224
           TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME
Sbjct: 132 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 191

Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284
           RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS
Sbjct: 192 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251

Query: 285 GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH 344
           GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH
Sbjct: 252 GNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAH 311

Query: 345 DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL 404
           DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL
Sbjct: 312 DASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITL 371

Query: 405 HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE 464
           HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE
Sbjct: 372 HVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLE 431

Query: 465 ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 506
           ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE
Sbjct: 432 ATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 473


>4QS9-A nrPDB
          Length = 474

 Score =  647 bits (1670), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 310/459 (67%), Positives = 377/459 (82%), Gaps = 2/459 (0%)

Query: 44  RAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHG 103
           R  A+++  E+  +TP + LR +ADAM  EM  GL +D  + LKMLISYVDNLP+GDE G
Sbjct: 14  RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKG 73

Query: 104 LFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV 163
           LFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA  L  FV
Sbjct: 74  LFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV 133

Query: 164 KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM 223
            TE EDFHLPEGRQRELGFTF+FPV QTS+SSG+LIKWTKGFSI   VG+DVV  L++A+
Sbjct: 134 ATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKAL 193

Query: 224 ERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283
           ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW GLLP+
Sbjct: 194 ERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPK 253

Query: 284 SGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343
           SG MVINMEWGNF+S  LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+LLK+A
Sbjct: 254 SGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMA 313

Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403
            DA+ FGD VP+KL   FI+RTP MSAMH+DTS DLK +G+K+KDIL V  TSL+ R + 
Sbjct: 314 EDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVV 373

Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463
           + +C+++A RGARL+AAGIYGILKKLGRD    +  + Q++VIA+DGGL+EHY +F  C+
Sbjct: 374 ISLCNIIATRGARLSAAGIYGILKKLGRDTTKDE--EVQKSVIAMDGGLFEHYTQFSECM 431

Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502
           E++L +LLG+EA+ SV V  +NDGSGIGAALLAASHS Y
Sbjct: 432 ESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 470


>1BDG-A nrPDB
          Length = 451

 Score =  274 bits (701), Expect = 6e-74,   Method: Compositional matrix adjust.
 Identities = 171/459 (37%), Positives = 253/459 (55%), Gaps = 31/459 (6%)

Query: 51  EVEQRFSTPTALLRGIADAMVEEMERGLR--ADPHAPLKMLISYVDNLPTGDEHGLFYAL 108
           E+ + F         I D M E M  GL+   +  + +KM  SYV   P G E G F AL
Sbjct: 14  EILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLAL 73

Query: 109 DLGGTNFRVIRVQLGGREK--RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 166
           DLGGTN+RV+ V L G+ K  R+  + Y    IP   M G+  ELF +IA  L  F++  
Sbjct: 74  DLGGTNYRVLSVTLEGKGKSPRIQERTY---CIPAEKMSGSGTELFKYIAETLADFLENN 130

Query: 167 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226
           G      + ++ +LGFTFSFP  Q  ++  TL++WTKGFS +G  G +V   L   ++++
Sbjct: 131 GM-----KDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185

Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGN 286
            L++K  A+VNDTVGTLA     D   A  +I+GTGTN AY+E ++ +    G+  +   
Sbjct: 186 ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV--KEPE 243

Query: 287 MVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343
           +VIN EWG F  +      R+ +D ++D +SL+PG+Q+YEKM+SGMYLGE+VR I++ L 
Sbjct: 244 VVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLV 303

Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403
               LF   +P +L+ R  L T  ++ +  D +H L +    L D L V         I 
Sbjct: 304 EQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIV 363

Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463
            + C++V +R A LA AGI  IL+++ R  V           + +DG LY+ + KF  C 
Sbjct: 364 RYACEMVVKRAAYLAGAGIACILRRINRSEV----------TVGVDGSLYKFHPKF--CE 411

Query: 464 EAT-LADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501
             T + D L +   +   ++L+ DGSG GAA +AAS ++
Sbjct: 412 RMTDMVDKL-KPKNTRFCLRLSEDGSGKGAAAIAASCTR 449


>5HFU-A nrPDB
          Length = 923

 Score =  273 bits (697), Expect = 2e-73,   Method: Compositional matrix adjust.
 Identities = 175/461 (37%), Positives = 261/461 (56%), Gaps = 33/461 (7%)

Query: 49  IEEVEQ-----RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDE 101
           +++V+Q     R S  T L   I+    +EME+GL A  H  A +KML ++V + P G E
Sbjct: 25  VQKVDQYLYHMRLSDETLL--EISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82

Query: 102 HGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELES 161
           HG F ALDLGGTNFRV+ V++     + V  + +  AIP  +M G+  +LFD IA  L +
Sbjct: 83  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142

Query: 162 FV-KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 220
           F+ K + +D  LP      LGFTFSFP HQT +    L+ WTKGF  +G  G DVVA + 
Sbjct: 143 FMDKLQIKDKKLP------LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 196

Query: 221 RAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTG 279
           +A++R+G  D+ + A+VNDTVGT+    Y D++    +I+GTG+NA Y+E    I    G
Sbjct: 197 KAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG 256

Query: 280 LLPRSGNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVR 336
                G M INMEWG F  +      R+++D  +D  SLNPG+Q++EKMISGMY+GE+VR
Sbjct: 257 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 313

Query: 337 RILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTS 396
            IL+K+A +  LFG  +  +L       T D+S +  +     K     ++  LG+ D +
Sbjct: 314 LILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPT 370

Query: 397 LEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHY 456
            E    T  +C +V+ R A L AA +  +L+++  ++    G ++ R+ I +DG +Y+ +
Sbjct: 371 QEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKH 426

Query: 457 KKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497
             F   L  T+  L+       V    + DGSG GAA++ A
Sbjct: 427 PHFAKRLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTA 464



 Score =  261 bits (667), Expect = 5e-70,   Method: Compositional matrix adjust.
 Identities = 169/440 (38%), Positives = 231/440 (52%), Gaps = 36/440 (8%)

Query: 70  MVEEMERGLRADPHA--PLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREK 127
           M  EMERGL  + HA  P+KML +YV   P G E G F ALDLGGTNFRV+ V++   + 
Sbjct: 497 MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 556

Query: 128 RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFP 187
             V    +  AIP  +M GT  ELFD I   +  F++  G      +G    LGFTFSFP
Sbjct: 557 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMG-----MKGVSLPLGFTFSFP 611

Query: 188 VHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGG 246
             Q S+    L+KWTKGF  +G  GEDVV  L  A+  R+  D+ V A+VNDTVGT+   
Sbjct: 612 CQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTC 671

Query: 247 RYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSERLP---R 303
            + D      +I+GTG+NA Y+E    +    G     G M +NMEWG F         R
Sbjct: 672 GFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFR 728

Query: 304 SDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFIL 363
           +++D A+D  SLNPG+Q +EKMISGMYLGEIVR IL+       LF   +  +L+ R I 
Sbjct: 729 TEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIF 788

Query: 364 RTPDMSAMHHDT------SHDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARL 417
            T  +S +  D          L+HLG          +++ +   I   VC +VA R A+L
Sbjct: 789 ETKFLSQIESDCLALLQVRAILQHLG---------LESTCDDSIIVKEVCTVVARRAAQL 839

Query: 418 AAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAAS 477
             AG+  ++ ++  +R    G    +  + +DG LY+ +  F   +  T+ DL       
Sbjct: 840 CGAGMAAVVDRIRENR----GLDALKVTVGVDGTLYKLHPHFAKVMHETVKDL---APKC 892

Query: 478 SVVVKLANDGSGIGAALLAA 497
            V    + DGSG GAAL+ A
Sbjct: 893 DVSFLQSEDGSGKGAALITA 912


>4FOI-A nrPDB
          Length = 917

 Score =  271 bits (694), Expect = 4e-73,   Method: Compositional matrix adjust.
 Identities = 181/469 (38%), Positives = 249/469 (53%), Gaps = 30/469 (6%)

Query: 35  REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92
           R AE+ R+      IEE    F     +L  +   M  EME GLR   H  A +KML S+
Sbjct: 462 RLAEQHRQ------IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSF 515

Query: 93  VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152
           V   P G E+G F ALDLGGTNFRV+ V++   +KR V    +  AIP  +M GT  ELF
Sbjct: 516 VRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF 575

Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212
           D I + +  F+     D+   +G +  LGFTFSFP  QTS+ +G LI WTKGF     VG
Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVG 630

Query: 213 EDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271
            DVV  L  A++ R+  D+ V A+VNDTVGT+    Y +      +I+GTG+NA Y+E  
Sbjct: 631 HDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEM 690

Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328
             +    G     G M INMEWG F         R+ YD  +D  SLN G+Q YEKMISG
Sbjct: 691 KNVEMVEG---DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISG 747

Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388
           MYLGEIVR IL+       LF   +   L+ R I  T  +S +  D    L  + A L+ 
Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806

Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448
            LG+ +++ +   +   VC +V+ R A+L  AG+  ++ K+  +R    G  +    + +
Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGV 860

Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497
           DG LY+ +  F   +  T+ +L       +V   L+ DGSG GAAL+ A
Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCNVSFLLSEDGSGKGAALITA 906



 Score =  256 bits (655), Expect = 1e-68,   Method: Compositional matrix adjust.
 Identities = 165/435 (37%), Positives = 247/435 (56%), Gaps = 30/435 (6%)

Query: 72  EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 129
           +EM+ GL  D  P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+   + + 
Sbjct: 45  KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104

Query: 130 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KTEGEDFHLPEGRQRELGFTFSFPV 188
           V  + E    P +++ G+  +LFD +A  L  F+ K + +D  LP      +GFTFSFP 
Sbjct: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLP------VGFTFSFPC 158

Query: 189 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 247
            Q+ I    LI WTK F  +G  G DVV  L++A++++G  D  + A+VNDTVGT+    
Sbjct: 159 QQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218

Query: 248 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 304
           Y D      +I+GTGTNA Y+E    I    G     G M IN EWG F  +      R+
Sbjct: 219 YDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275

Query: 305 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 364
           ++D  +D  SLNPG+Q++EKM+SGMYLGE+VR IL+K+A +  LF   +  +L  R    
Sbjct: 276 EFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335

Query: 365 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 422
           T D+SA+  +    H+ K +  +    LGV  +  +   +  HVC +V+ R A L AA +
Sbjct: 336 TSDVSAIEKNKEGLHNAKEILTR----LGVEPSDDDCVSVQ-HVCTIVSFRSANLVAATL 390

Query: 423 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 482
             IL +L RD   + G+ + RT + ++G LY+ + ++      TL  L+ +   S V   
Sbjct: 391 GAILNRL-RD---NKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVPD---SDVRFL 443

Query: 483 LANDGSGIGAALLAA 497
           L+  GSG GAA++ A
Sbjct: 444 LSESGSGKGAAMVTA 458


>1BG3-A nrPDB
          Length = 918

 Score =  271 bits (693), Expect = 5e-73,   Method: Compositional matrix adjust.
 Identities = 177/469 (37%), Positives = 252/469 (53%), Gaps = 30/469 (6%)

Query: 35  REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92
           R AE+ R+      IEE    F      L  +   +  EME GLR + +  A +KML S+
Sbjct: 462 RLAEQHRQ------IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSF 515

Query: 93  VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152
           V ++P G EHG F ALDLGGTNFRV+ V++   +KR V    +  +IP  +M GT  ELF
Sbjct: 516 VRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELF 575

Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212
           D I + +  F+     D+   +G +  LGFTFSFP HQT++  G LI WTKGF      G
Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEG 630

Query: 213 EDVVAELSRAME-RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271
            DV + L  A++ R+  D+ V A+VNDTVGT+    Y +      +I+GTGTNA Y+E  
Sbjct: 631 HDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEM 690

Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328
             +    G     G M INMEWG F         R+D+D  +D  SLN G+Q +EKMISG
Sbjct: 691 KNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISG 747

Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388
           MYLGEIVR IL+       LF   +   L+ R I  T  +S +  D    L  + A L+ 
Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806

Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448
            LG+ +++ +   +   VC +V++R A+L  AG+  +++K+  +R    G       + +
Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGV 860

Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497
           DG LY+ +  F   +  T+ +L       +V   L+ DGSG GAAL+ A
Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITA 906



 Score =  255 bits (652), Expect = 3e-68,   Method: Compositional matrix adjust.
 Identities = 163/435 (37%), Positives = 246/435 (56%), Gaps = 30/435 (6%)

Query: 72  EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 129
           +EM+ GL  D  P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+   + + 
Sbjct: 45  KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104

Query: 130 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFH-LPEGRQRELGFTFSFPV 188
           VS + E    P +++ G+  +LFD +A  L  F++ +      LP      +GFTFSFP 
Sbjct: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLP------VGFTFSFPC 158

Query: 189 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 247
            Q+ I    LI WTK F  +G  G DVV  L++A++++G  D  + A+VNDTVGT+    
Sbjct: 159 RQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218

Query: 248 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 304
           Y D      +I+GTGTNA Y+E    I    G     G M IN EWG F  +      R+
Sbjct: 219 YDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275

Query: 305 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 364
           ++D  LD  SLNPG+Q++EKM+SGMY+GE+VR IL+K+A +  LF   +  +L  R    
Sbjct: 276 EFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335

Query: 365 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 422
           T D+SA+  D     + K +  +    LGV  + ++   +  H+C +V+ R A L AA +
Sbjct: 336 TSDVSAIEKDKEGIQNAKEILTR----LGVEPSDVDCVSVQ-HICTIVSFRSANLVAATL 390

Query: 423 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 482
             IL +L RD   + G+ + RT + +DG LY+ + ++      TL  L+ +   S V   
Sbjct: 391 GAILNRL-RD---NKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRFL 443

Query: 483 LANDGSGIGAALLAA 497
           L+  G+G GAA++ A
Sbjct: 444 LSESGTGKGAAMVTA 458


>3O1W-A nrPDB
          Length = 485

 Score =  265 bits (676), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 167/461 (36%), Positives = 237/461 (51%), Gaps = 31/461 (6%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108
           I  +E  F+  +  +R I    + E+++GL +     + M+  +V   PTG E G F AL
Sbjct: 27  IHGLETLFTVSSEKMRSIVKHFISELDKGL-SKKGGNIPMIPGWVVEYPTGKETGDFLAL 85

Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGE 168
           DLGGTN RV+ V+LGG      +Q   +  +P HL  GTS +L+ FIA  L+ FV     
Sbjct: 86  DLGGTNLRVVLVKLGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV----- 138

Query: 169 DFHLPEGRQREL--GFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226
           D   P+G    L  GFTFS+P  Q  I+SG L +WTKGF I G  G DVV  L   +E+ 
Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198

Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR--- 283
            + + V AL+NDT GTL    Y D      +I+GTG N AY +  + I K  GLLP    
Sbjct: 199 NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIG 258

Query: 284 -SGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
               M IN E+G+F +E   LPR+ YD  +D ES  PG+Q +EKM SG YLGEI+R +LL
Sbjct: 259 PDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLL 318

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
            L     +F D   +KL++ +++ T   S +  D   +L+      K  L +  T +E +
Sbjct: 319 DLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERK 378

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
            I   + +LV  R ARL   G+  I  K G           +   IA DG ++  Y  ++
Sbjct: 379 LIR-KLAELVGTRAARLTVCGVSAICDKRGY----------KTAHIAADGSVFNRYPGYK 427

Query: 461 TCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 497
                 L D+   +        + +  A DGSG+GAA++A 
Sbjct: 428 EKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIAC 468


>3HM8-A nrPDB
          Length = 445

 Score =  258 bits (660), Expect = 3e-69,   Method: Compositional matrix adjust.
 Identities = 177/465 (38%), Positives = 258/465 (55%), Gaps = 33/465 (7%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYA 107
           ++EE    F      L  +   M + M +GLR +  + L+ML ++V   P G E G F A
Sbjct: 5   LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASS-LRMLPTFVRATPDGSERGDFLA 63

Query: 108 LDLGGTNFRV--IRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165
           LDLGGTNFRV  +RV  G    ++ S+ Y   +IP  +  G+  +LFD I   +  F + 
Sbjct: 64  LDLGGTNFRVLLVRVTTG---VQITSEIY---SIPETVAQGSGQQLFDHIVDCIVDFQQK 117

Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM-E 224
           +G       G+   LGFTFSFP  Q  +  G L+ WTKGF  +   G+DVV+ L  A+  
Sbjct: 118 QG-----LSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITR 172

Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284
           RQ +++ V A+VNDTVGT+    Y D      +I+GTGTNA Y+E    +    G+   S
Sbjct: 173 RQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNV---AGVPGDS 229

Query: 285 GNMVINMEWGNFK---SERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341
           G M INMEWG F    S  +  + +D ++D  S+NPG+Q +EKMISGMYLGEIVR ILL 
Sbjct: 230 GRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLH 289

Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401
           L     LF      +L+ R I +T  +S +  D S  L+ + A L+D LG+  TS +A  
Sbjct: 290 LTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTSDDA-L 346

Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461
           + L VC  V++R A+L  AG+  +++K+  +R    G ++    + +DG LY+ + +F +
Sbjct: 347 MVLEVCQAVSQRAAQLCGAGVAAVVEKIRENR----GLEELAVSVGVDGTLYKLHPRFSS 402

Query: 462 CLEATLADLLGEEAASSVVVKL-ANDGSGIGAALLAASHSQYASV 505
            + AT+ +L    A   VV  L + DGSG GAAL+ A   + A +
Sbjct: 403 LVAATVREL----APRCVVTFLQSEDGSGKGAALVTAVACRLAQL 443


>3W0L-A nrPDB
          Length = 458

 Score =  251 bits (641), Expect = 5e-67,   Method: Compositional matrix adjust.
 Identities = 167/459 (36%), Positives = 249/459 (54%), Gaps = 30/459 (6%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGL--RADPHAPLKMLISYVDNLPTGDEHGLFY 106
           ++++   F      L  +   M  EMERGL    +  A +KML +YV + P G E G F 
Sbjct: 9   VDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFL 68

Query: 107 ALDLGGTNFRVIRVQLG----GREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESF 162
           ALDLGGTNFRV+ V++G    G+ K  V  +++  +IP   M GT+  LFD+IA  +  +
Sbjct: 69  ALDLGGTNFRVMLVKVGEDLEGQWK--VETKHKMYSIPVDAMTGTAEMLFDYIAECISDY 126

Query: 163 VKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRA 222
           +  +       + ++  LGFTFSFPV    I  G L+ WTKGF  +G  G +VV  L  A
Sbjct: 127 LDQQN-----MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDA 181

Query: 223 MERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL 281
           ++R+G  +M V A+VNDTV T+    Y D+     +I+GTG NA Y+E  + +    G  
Sbjct: 182 IKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEG-- 239

Query: 282 PRSGNMVINMEWGNF-KSERLP--RSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 338
              G M +N EWG F  +  L   R +YD  +D  SLNPG+Q+YEKMI G Y+GE+VR +
Sbjct: 240 -EEGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLV 298

Query: 339 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 398
           L+K+ ++  LFG     KL+ R    T  +S +  DTS D K     L+  LGV  T  +
Sbjct: 299 LIKMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILR-TLGVQATIGD 356

Query: 399 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 458
              + L  C+ V+ R A + +AG+ GIL ++ + R      +  R  + +DG +Y+ +  
Sbjct: 357 CHAVRL-ACESVSTRAAIMCSAGLAGILNRMRQSR----REELLRITVGVDGSVYKLHPS 411

Query: 459 FRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 497
           F+    AT+  L    +   +    + +GSG GAAL++A
Sbjct: 412 FKDKFHATVLKLT---SGCEITFIQSEEGSGRGAALISA 447


>1IG8-A nrPDB
          Length = 486

 Score =  247 bits (630), Expect = 9e-66,   Method: Compositional matrix adjust.
 Identities = 153/439 (34%), Positives = 227/439 (51%), Gaps = 30/439 (6%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108
           IE  E+ F+ PT  L+ +    + E+E+GL +     + M+  +V + PTG E G F A+
Sbjct: 27  IENFEKIFTVPTETLQAVTKHFISELEKGL-SKKGGNIPMIPGWVMDFPTGKESGDFLAI 85

Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 166
           DLGGTN RV+ V+LGG      +Q    +   P  M  T    EL++FIA  L++F+   
Sbjct: 86  DLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQNPDELWEFIADSLKAFI--- 139

Query: 167 GEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224
             D   P+G      LGFTFSFP  Q  I+ G L +WTKGF I      DVV  L + + 
Sbjct: 140 --DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197

Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL--- 281
           ++ + ++V AL+NDT GTL    Y D +    VI GTG N AY +  + I K  G L   
Sbjct: 198 KRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257

Query: 282 -PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 338
            P S  M IN E+G+F +E   LPR+ YD  +D ES  PG+Q +EKM SG YLGEI+R  
Sbjct: 258 IPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLA 317

Query: 339 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 398
           L+ +     +F +   +K ++ F++ T   + +  D   +L+      ++  G+ +T+++
Sbjct: 318 LMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI-NTTVQ 376

Query: 399 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 458
            R +   + +L+  R ARL+  GI  I +K G           +   IA DG +Y  Y  
Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGY----------KTGHIAADGSVYNRYPG 426

Query: 459 FRTCLEATLADLLGEEAAS 477
           F+      L D+ G    S
Sbjct: 427 FKEKAANALKDIYGWTQTS 445


>4DCH-A nrPDB
          Length = 473

 Score =  238 bits (607), Expect = 5e-63,   Method: Compositional matrix adjust.
 Identities = 167/478 (34%), Positives = 254/478 (53%), Gaps = 29/478 (6%)

Query: 39  EERRRRAAAVIEEVEQ---RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYV 93
           ++R R  AA  E+VEQ    F      L+ +   M +EM+RGLR + H  A +KML +YV
Sbjct: 3   DDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYV 62

Query: 94  DNLPTGDEHGLFYALDLGGTNFRVIRVQLGGRE--KRVVSQQYEEVAIPPHLMVGTSMEL 151
            + P G E G F +LDLGGTNFRV+ V++G  E  +  V  +++  +IP   M GT+  L
Sbjct: 63  RSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML 122

Query: 152 FDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTV 211
           FD+I+  +  F+     D H  + ++  LGFTFSFPV    I  G L+ WTKGF  +G  
Sbjct: 123 FDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAE 177

Query: 212 GEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEH 270
           G +VV  L  A++R+G  +M V A+VNDTV T+    Y D+     +I+GTG NA Y+E 
Sbjct: 178 GNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEE 237

Query: 271 ANAIPKWTGLLPRSGNMVINMEWGNF-KSERLPRS--DYDNALDFESLNPGEQIYEKMIS 327
              +    G     G M +N EWG F  S  L     +YD  +D  S NPG+Q+YEK+I 
Sbjct: 238 MQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIG 294

Query: 328 GMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLK 387
           G Y+GE+VR +LL+L  +  LF      +L  R    T  +S +  DT  D K +   + 
Sbjct: 295 GKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQI-YNIL 352

Query: 388 DILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIA 447
             LG+  ++ +   I    C+ V+ R A + +AG+ G++ ++   R         R  + 
Sbjct: 353 STLGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVG 407

Query: 448 LDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505
           +DG +Y+ +  F+    A++  L     +  +    + +GSG GAAL++A   + A +
Sbjct: 408 VDGSVYKLHPSFKERFHASVRRLT---PSCEITFIESEEGSGRGAALVSAVACKKACM 462


>3B8A-X nrPDB
          Length = 485

 Score =  234 bits (596), Expect = 8e-62,   Method: Compositional matrix adjust.
 Identities = 163/460 (35%), Positives = 240/460 (52%), Gaps = 29/460 (6%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108
           I ++E  F+  +  LR +    ++E+ +GL       + M+  +V   PTG E G + A+
Sbjct: 27  IHQLEDMFTVDSETLRKVVKHFIDELNKGLTKK-GGNIPMIPGWVMEFPTGKESGNYLAI 85

Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 166
           DLGGTN RV+ V+L G      +Q   ++   PH M  T    EL+ FIA  L+ F+  E
Sbjct: 86  DLGGTNLRVVLVKLSGNHTFDTTQSKYKL---PHDMRTTKHQEELWSFIADSLKDFM-VE 141

Query: 167 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226
            E  +  +     LGFTFS+P  Q  I+ G L +WTKGF I    G DVV  L   + ++
Sbjct: 142 QELLNTKD--TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR 199

Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL----P 282
            L +++ AL+NDTVGTL    Y D +    VI GTG N A+ +  + I K  G L    P
Sbjct: 200 ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIP 259

Query: 283 RSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
            +  M IN E+G+F +E   LPR+ YD A+D +S  PG+Q +EKM SG YLGE++R +LL
Sbjct: 260 SNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLL 319

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
           +L     +  D   +KL+Q +I+ T   + +  D   +L+      +   GV  T+L  R
Sbjct: 320 ELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVK-TTLPER 378

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
            +   +C+L+  R ARLA  GI  I +K G           +   IA DG +Y  Y  F+
Sbjct: 379 KLIRRLCELIGTRAARLAVCGIAAICQKRGY----------KTGHIAADGSVYNKYPGFK 428

Query: 461 TCLEATLADLL---GEEAASSVVVKLANDGSGIGAALLAA 497
                 L D+    G+ +   + +  A DGSG GAA++AA
Sbjct: 429 EAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAA 468


>2YHX-A nrPDB
          Length = 457

 Score = 39.3 bits (90), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 22/218 (10%)

Query: 56  FSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNF 115
           F  P  +L+ +   +    +    +    P  M+  +V    +G + G F A+ +GG + 
Sbjct: 16  FIVPPXILQAVVSILTTRXDDXDSSAASIP--MVPGWVLKQVSGAQAGSFLAIVMGGGDL 73

Query: 116 RVIRVQLGGREK------RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGED 169
            VI + L GR++      R ++      AIP  L    +       +    S  +     
Sbjct: 74  EVILISLAGRQESSIXASRSLAAAMSTTAIPSDLWGNXAX------SNAAFSSXEFSSXA 127

Query: 170 FHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQGLD 229
             +P      LGFTF     +  +  G +      FS+       +++ +  A    G  
Sbjct: 128 GSVP------LGFTFXEAGAKEXVIKGQITXQAXAFSLAXL--XKLISAMXNAXFPAGDX 179

Query: 230 MKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAY 267
               A + D+ G L    Y D  +   +I G+G NAAY
Sbjct: 180 XXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217


>1HKG-A nrPDB
          Length = 457

 Score = 36.2 bits (82), Expect = 0.031,   Method: Compositional matrix adjust.
 Identities = 42/188 (22%), Positives = 71/188 (37%), Gaps = 20/188 (10%)

Query: 86  LKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREK------RVVSQQYEEVAI 139
           + M+  +V     G + G F A+ +GG +  VI + L G ++      R ++      AI
Sbjct: 44  IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103

Query: 140 PPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLI 199
           P  L    +       +    S  +       +P      LGFTF     +  +  G + 
Sbjct: 104 PSDLWGNXAX------SNAAFSSXEFSSXAGSVP------LGFTFXEAGAKEXVIKGQIT 151

Query: 200 KWTKGFSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVIL 259
                FS+       +++ +  A    G      A + D+ G L    Y D  +   +I 
Sbjct: 152 XQAXAFSLAXL--XKLISAMXNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIF 209

Query: 260 GTGTNAAY 267
           G+G NAAY
Sbjct: 210 GSGVNAAY 217


>4OVD-A nrPDB
          Length = 564

 Score = 33.5 bits (75), Expect = 0.20,   Method: Compositional matrix adjust.
 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 11/66 (16%)

Query: 298 SERLPRSDYDNALDFESLNPGEQIYEKMISGMY-LGEIVRRILLKLAHDASLFGD----V 352
           S  LP  + DN +D+ESLN       K++S +Y  G + + I   +  D +LFG      
Sbjct: 265 SYPLPDFESDNGVDYESLN------LKLVSSIYEPGSVFKVITTSIGVDNNLFGPNSTFN 318

Query: 353 VPTKLE 358
           +PT+L+
Sbjct: 319 IPTELQ 324


>5ZEP-H nrPDB
          Length = 151

 Score = 30.4 bits (67), Expect = 2.0,   Method: Compositional matrix adjust.
 Identities = 20/47 (42%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 22 GVAVVVSRRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIAD 68
          G+A+V SR   ++R+AEE RR R + VI ++E      TA L G+ D
Sbjct: 34 GLAIVASRG--AERQAEEIRRARESKVIRDIEHANELKTA-LEGLGD 77


>2IZO-A nrPDB
          Length = 346

 Score = 29.3 bits (64), Expect = 4.0,   Method: Compositional matrix adjust.
 Identities = 22/55 (40%), Positives = 38/55 (69%), Gaps = 5/55 (9%)

Query: 27  VSRRRRSKREAEEE-RRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRA 80
           + RRR++K EAE +  R ++   IEE+ +++S   A+LR +++ MVEE ++ LRA
Sbjct: 88  LERRRKAKEEAERKLERAKSEGKIEEL-RKYSQ--AILR-LSNIMVEESKKLLRA 138


>4B2T-A nrPDB
          Length = 556

 Score = 28.9 bits (63), Expect = 5.0,   Method: Compositional matrix adjust.
 Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 8/107 (7%)

Query: 57  STPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFR 116
           ++ + +LRG  D M +EMER L  D    +K ++     +P G    +  AL +   N+ 
Sbjct: 371 TSASVILRGANDFMCDEMERSLH-DALCVVKRVLESKSVVPGG--GAVEAALSIYLENY- 426

Query: 117 VIRVQLGGREKRVVSQQYEEV-AIPPHLMVGTSMELFDFIAAELESF 162
                +G RE+  +++    +  IP  L V  + +  D + A+L +F
Sbjct: 427 --ATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLV-AKLRAF 470


>6FPX-A nrPDB
          Length = 192

 Score = 28.9 bits (63), Expect = 5.4,   Method: Compositional matrix adjust.
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 4/52 (7%)

Query: 382 LGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDR 433
             A++ +I+   D   EAR       +++ + G+RL     Y I+K++GRDR
Sbjct: 145 FSAEISEIVSHMDHGSEAR----DGMEMMYDEGSRLCTLINYAIMKRIGRDR 192


>6D7W-A nrPDB
          Length = 416

 Score = 28.9 bits (63), Expect = 6.2,   Method: Compositional matrix adjust.
 Identities = 12/22 (54%), Positives = 15/22 (68%)

Query: 405 HVCDLVAERGARLAAAGIYGIL 426
           H CD +A RGA+  A G +GIL
Sbjct: 257 HECDALAHRGAQRVALGGFGIL 278


>5HFZ-A nrPDB
          Length = 170

 Score = 28.9 bits (63), Expect = 6.2,   Method: Compositional matrix adjust.
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 4/52 (7%)

Query: 382 LGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDR 433
             A++ +I+   D   EAR       +++ + G+RL     Y I+K++GRDR
Sbjct: 123 FSAEISEIVSHMDHGSEAR----DGMEMMYDEGSRLCTLINYAIMKRIGRDR 170


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

5ZQT-A nrPDB                                                          644   0.0  
1BG3-A nrPDB                                                          627   e-180
4FOI-A nrPDB                                                          627   e-180
4QS9-A nrPDB                                                          608   e-174
5HFU-A nrPDB                                                          593   e-170
3O1W-A nrPDB                                                          584   e-167
3W0L-A nrPDB                                                          584   e-167
4DCH-A nrPDB                                                          576   e-165
3HM8-A nrPDB                                                          568   e-162
1IG8-A nrPDB                                                          567   e-162
3B8A-X nrPDB                                                          558   e-159
1BDG-A nrPDB                                                          548   e-156

Sequences not found previously or not previously below threshold:

2YHX-A nrPDB                                                          139   3e-33
1HKG-A nrPDB                                                          135   6e-32
1Q1R-A nrPDB                                                           29   4.9  
1E19-A nrPDB                                                           29   6.0  
6MU0-A nrPDB                                                           29   6.1  
2WD5-A nrPDB                                                           28   7.9  
2BWY-A nrPDB                                                           28   8.0  
1Q5D-A nrPDB                                                           28   9.7  

>5ZQT-A nrPDB
          Length = 473

 Score =  644 bits (1661), Expect = 0.0,   Method: Composition-based stats.
 Identities = 463/466 (99%), Positives = 463/466 (99%)

Query: 41  RRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD 100
           R   AAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD
Sbjct: 8   RIPMAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGD 67

Query: 101 EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE 160
           EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE
Sbjct: 68  EHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELE 127

Query: 161 SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 220
           SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS
Sbjct: 128 SFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 187

Query: 221 RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL 280
           RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL
Sbjct: 188 RAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGL 247

Query: 281 LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
           LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL
Sbjct: 248 LPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 307

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
           KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR
Sbjct: 308 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 367

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
           YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR
Sbjct: 368 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 427

Query: 461 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 506
           TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE
Sbjct: 428 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASVE 473


>1BG3-A nrPDB
          Length = 918

 Score =  627 bits (1618), Expect = e-180,   Method: Composition-based stats.
 Identities = 177/474 (37%), Positives = 253/474 (53%), Gaps = 30/474 (6%)

Query: 35  REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92
           R AE+ R+      IEE    F      L  +   +  EME GLR + +  A +KML S+
Sbjct: 462 RLAEQHRQ------IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSF 515

Query: 93  VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152
           V ++P G EHG F ALDLGGTNFRV+ V++   +KR V    +  +IP  +M GT  ELF
Sbjct: 516 VRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELF 575

Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212
           D I + +  F+     D+   +G +  LGFTFSFP HQT++  G LI WTKGF      G
Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEG 630

Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271
            DV + L  A++R+   D+ V A+VNDTVGT+    Y +      +I+GTGTNA Y+E  
Sbjct: 631 HDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEM 690

Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328
             +    G     G M INMEWG F         R+D+D  +D  SLN G+Q +EKMISG
Sbjct: 691 KNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISG 747

Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388
           MYLGEIVR IL+       LF   +   L+ R I  T  +S +  D    L  + A L+ 
Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806

Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448
            LG+ +++ +   +   VC +V++R A+L  AG+  +++K+  +R    G       + +
Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGV 860

Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502
           DG LY+ +  F   +  T+ +L       +V   L+ DGSG GAAL+ A   + 
Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITAVGVRL 911



 Score =  494 bits (1271), Expect = e-140,   Method: Composition-based stats.
 Identities = 163/463 (35%), Positives = 249/463 (53%), Gaps = 24/463 (5%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLF 105
            I++          +L  I     +EM+ GL  D  P A +KML ++V ++P G E G F
Sbjct: 21  KIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF 80

Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165
            ALDLGG++FR++RVQ+   + + VS + E    P +++ G+  +LFD +A  L  F++ 
Sbjct: 81  IALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEK 140

Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225
           +             +GFTFSFP  Q+ I    LI WTK F  +G  G DVV  L++A+++
Sbjct: 141 KKIKDKK-----LPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195

Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284
           +G  D  + A+VNDTVGT+    Y D      +I+GTGTNA Y+E    I    G     
Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252

Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341
           G M IN EWG F  +      R+++D  LD  SLNPG+Q++EKM+SGMY+GE+VR IL+K
Sbjct: 253 GRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 312

Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401
           +A +  LF   +  +L  R    T D+SA+  D    +++    L   LGV  + ++   
Sbjct: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEILTR-LGVEPSDVDC-V 369

Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461
              H+C +V+ R A L AA +  IL +L  ++    G+ + RT + +DG LY+ + ++  
Sbjct: 370 SVQHICTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVDGSLYKMHPQYSR 425

Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYAS 504
               TL  L+     S V   L+  G+G GAA++ A   + A 
Sbjct: 426 RFHKTLRRLV---PDSDVRFLLSESGTGKGAAMVTAVAYRLAE 465


>4FOI-A nrPDB
          Length = 917

 Score =  627 bits (1617), Expect = e-180,   Method: Composition-based stats.
 Identities = 181/474 (38%), Positives = 250/474 (52%), Gaps = 30/474 (6%)

Query: 35  REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISY 92
           R AE+ R+      IEE    F     +L  +   M  EME GLR   H  A +KML S+
Sbjct: 462 RLAEQHRQ------IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSF 515

Query: 93  VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152
           V   P G E+G F ALDLGGTNFRV+ V++   +KR V    +  AIP  +M GT  ELF
Sbjct: 516 VRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELF 575

Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212
           D I + +  F+     D+   +G +  LGFTFSFP  QTS+ +G LI WTKGF     VG
Sbjct: 576 DHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVG 630

Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271
            DVV  L  A++R+   D+ V A+VNDTVGT+    Y +      +I+GTG+NA Y+E  
Sbjct: 631 HDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEM 690

Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISG 328
             +    G     G M INMEWG F         R+ YD  +D  SLN G+Q YEKMISG
Sbjct: 691 KNVEMVEG---DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISG 747

Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388
           MYLGEIVR IL+       LF   +   L+ R I  T  +S +  D    L  + A L+ 
Sbjct: 748 MYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ 806

Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448
            LG+ +++ +   +   VC +V+ R A+L  AG+  ++ K+  +R    G  +    + +
Sbjct: 807 -LGL-NSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGV 860

Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502
           DG LY+ +  F   +  T+ +L       +V   L+ DGSG GAAL+ A   + 
Sbjct: 861 DGTLYKLHPHFSRIMHQTVKEL---SPKCNVSFLLSEDGSGKGAALITAVGVRL 911



 Score =  498 bits (1282), Expect = e-141,   Method: Composition-based stats.
 Identities = 164/463 (35%), Positives = 247/463 (53%), Gaps = 24/463 (5%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLF 105
            I++           L  I     +EM+ GL  D  P A +KML ++V ++P G E G F
Sbjct: 21  KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80

Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165
            ALDLGG++FR++RVQ+   + + V  + E    P +++ G+  +LFD +A  L  F++ 
Sbjct: 81  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 140

Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225
                   + ++  +GFTFSFP  Q+ I    LI WTK F  +G  G DVV  L++A+++
Sbjct: 141 RK-----IKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195

Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284
           +G  D  + A+VNDTVGT+    Y D      +I+GTGTNA Y+E    I    G     
Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252

Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341
           G M IN EWG F  +      R+++D  +D  SLNPG+Q++EKM+SGMYLGE+VR IL+K
Sbjct: 253 GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK 312

Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401
           +A +  LF   +  +L  R    T D+SA+  +    L +    L   LGV   S +   
Sbjct: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEILTR-LGVE-PSDDDCV 369

Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461
              HVC +V+ R A L AA +  IL +L  ++    G+ + RT + ++G LY+ + ++  
Sbjct: 370 SVQHVCTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVNGSLYKTHPQYSR 425

Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYAS 504
               TL  L+     S V   L+  GSG GAA++ A   + A 
Sbjct: 426 RFHKTLRRLV---PDSDVRFLLSESGSGKGAAMVTAVAYRLAE 465


>4QS9-A nrPDB
          Length = 474

 Score =  608 bits (1567), Expect = e-174,   Method: Composition-based stats.
 Identities = 310/459 (67%), Positives = 376/459 (81%), Gaps = 2/459 (0%)

Query: 44  RAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHG 103
           R  A+++  E+  +TP + LR +ADAM  EM  GL +D  + LKMLISYVDNLP+GDE G
Sbjct: 14  RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKG 73

Query: 104 LFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV 163
           LFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA  L  FV
Sbjct: 74  LFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV 133

Query: 164 KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM 223
            TE EDFHLPEGRQRELGFTF+FPV QTS+SSG+LIKWTKGFSI   VG+DVV  L++A+
Sbjct: 134 ATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKAL 193

Query: 224 ERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283
           ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW GLLP+
Sbjct: 194 ERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPK 253

Query: 284 SGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343
           SG MVINMEWGNF+S  LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+LLK+A
Sbjct: 254 SGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMA 313

Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403
            DA+ FGD VP+KL   FI+RTP MSAMH+DTS DLK +G+K+KDIL V  TSL+ R + 
Sbjct: 314 EDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVV 373

Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463
           + +C+++A RGARL+AAGIYGILKKLGRD       + Q++VIA+DGGL+EHY +F  C+
Sbjct: 374 ISLCNIIATRGARLSAAGIYGILKKLGRDTTKD--EEVQKSVIAMDGGLFEHYTQFSECM 431

Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 502
           E++L +LLG+EA+ SV V  +NDGSGIGAALLAASHS Y
Sbjct: 432 ESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 470


>5HFU-A nrPDB
          Length = 923

 Score =  593 bits (1528), Expect = e-170,   Method: Composition-based stats.
 Identities = 173/473 (36%), Positives = 244/473 (51%), Gaps = 30/473 (6%)

Query: 35  REAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAP--LKMLISY 92
           R A++ R R      ++  +        L  +   M  EMERGL  + HA   +KML +Y
Sbjct: 468 RLADQHRAR------QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTY 521

Query: 93  VDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELF 152
           V   P G E G F ALDLGGTNFRV+ V++   +   V    +  AIP  +M GT  ELF
Sbjct: 522 VCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELF 581

Query: 153 DFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVG 212
           D I   +  F++     +   +G    LGFTFSFP  Q S+    L+KWTKGF  +G  G
Sbjct: 582 DHIVQCIADFLE-----YMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEG 636

Query: 213 EDVVAELSRAMERQ-GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHA 271
           EDVV  L  A+ R+   D+ V A+VNDTVGT+    + D      +I+GTG+NA Y+E  
Sbjct: 637 EDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEM 696

Query: 272 NAIPKWTGLLPRSGNMVINMEWGNFKSERLP---RSDYDNALDFESLNPGEQIYEKMISG 328
             +    G     G M +NMEWG F         R+++D A+D  SLNPG+Q +EKMISG
Sbjct: 697 RNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 753

Query: 329 MYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKD 388
           MYLGEIVR IL+       LF   +  +L+ R I  T  +S +  D    L  + A L+ 
Sbjct: 754 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA-LLQVRAILQH 812

Query: 389 ILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIAL 448
            LG+  ++ +   I   VC +VA R A+L  AG+  ++ ++  +R    G    +  + +
Sbjct: 813 -LGLE-STCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENR----GLDALKVTVGV 866

Query: 449 DGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501
           DG LY+ +  F   +  T+ DL        V    + DGSG GAAL+ A   +
Sbjct: 867 DGTLYKLHPHFAKVMHETVKDL---APKCDVSFLQSEDGSGKGAALITAVACR 916



 Score =  584 bits (1505), Expect = e-167,   Method: Composition-based stats.
 Identities = 168/462 (36%), Positives = 255/462 (55%), Gaps = 24/462 (5%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLF 105
            +++           L  I+    +EME+GL A  H  A +KML ++V + P G EHG F
Sbjct: 27  KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 86

Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165
            ALDLGGTNFRV+ V++     + V  + +  AIP  +M G+  +LFD IA  L +F+  
Sbjct: 87  LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFM-- 144

Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225
              D    + ++  LGFTFSFP HQT +    L+ WTKGF  +G  G DVVA + +A++R
Sbjct: 145 ---DKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 201

Query: 226 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 284
           +G  D+ + A+VNDTVGT+    Y D++    +I+GTG+NA Y+E    I    G     
Sbjct: 202 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DE 258

Query: 285 GNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 341
           G M INMEWG F  +      R+++D  +D  SLNPG+Q++EKMISGMY+GE+VR IL+K
Sbjct: 259 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 318

Query: 342 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 401
           +A +  LFG  +  +L       T D+S +  +     K     ++  LG+ D + E   
Sbjct: 319 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPTQEDCV 375

Query: 402 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 461
            T  +C +V+ R A L AA +  +L+++  ++    G ++ R+ I +DG +Y+ +  F  
Sbjct: 376 ATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKHPHFAK 431

Query: 462 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYA 503
            L  T+  L+       V    + DGSG GAA++ A   + A
Sbjct: 432 RLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTAVAYRLA 470


>3O1W-A nrPDB
          Length = 485

 Score =  584 bits (1506), Expect = e-167,   Method: Composition-based stats.
 Identities = 167/461 (36%), Positives = 237/461 (51%), Gaps = 31/461 (6%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 108
           I  +E  F+  +  +R I    + E+++GL +     + M+  +V   PTG E G F AL
Sbjct: 27  IHGLETLFTVSSEKMRSIVKHFISELDKGL-SKKGGNIPMIPGWVVEYPTGKETGDFLAL 85

Query: 109 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGE 168
           DLGGTN RV+ V+LGG      +Q   +  +P HL  GTS +L+ FIA  L+ FV     
Sbjct: 86  DLGGTNLRVVLVKLGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV----- 138

Query: 169 DFHLPEGRQ--RELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ 226
           D   P+G      LGFTFS+P  Q  I+SG L +WTKGF I G  G DVV  L   +E+ 
Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198

Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR--- 283
            + + V AL+NDT GTL    Y D      +I+GTG N AY +  + I K  GLLP    
Sbjct: 199 NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIG 258

Query: 284 -SGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
               M IN E+G+F +E   LPR+ YD  +D ES  PG+Q +EKM SG YLGEI+R +LL
Sbjct: 259 PDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLL 318

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
            L     +F D   +KL++ +++ T   S +  D   +L+      K  L +  T +E R
Sbjct: 319 DLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE-R 377

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
            +   + +LV  R ARL   G+  I  K G           +   IA DG ++  Y  ++
Sbjct: 378 KLIRKLAELVGTRAARLTVCGVSAICDKRGY----------KTAHIAADGSVFNRYPGYK 427

Query: 461 TCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 497
                 L D+   +        + +  A DGSG+GAA++A 
Sbjct: 428 EKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIAC 468


>3W0L-A nrPDB
          Length = 458

 Score =  584 bits (1505), Expect = e-167,   Method: Composition-based stats.
 Identities = 165/465 (35%), Positives = 248/465 (53%), Gaps = 26/465 (5%)

Query: 49  IEEVEQRFSTPTALLRGIADAMVEEMERGL--RADPHAPLKMLISYVDNLPTGDEHGLFY 106
           ++++   F      L  +   M  EMERGL    +  A +KML +YV + P G E G F 
Sbjct: 9   VDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFL 68

Query: 107 ALDLGGTNFRVIRVQLGGR--EKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVK 164
           ALDLGGTNFRV+ V++G     +  V  +++  +IP   M GT+  LFD+IA  +  ++ 
Sbjct: 69  ALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYLD 128

Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224
            +       + ++  LGFTFSFPV    I  G L+ WTKGF  +G  G +VV  L  A++
Sbjct: 129 QQN-----MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 183

Query: 225 RQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPR 283
           R+G  +M V A+VNDTV T+    Y D+     +I+GTG NA Y+E  + +    G    
Sbjct: 184 RRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEG---E 240

Query: 284 SGNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
            G M +N EWG F         R +YD  +D  SLNPG+Q+YEKMI G Y+GE+VR +L+
Sbjct: 241 EGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLI 300

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
           K+ ++  LFG     KL+ R    T  +S +  DTS D K     L+  LGV  T  +  
Sbjct: 301 KMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILR-TLGVQATIGDCH 358

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
            + L  C+ V+ R A + +AG+ GIL ++ + R      +  R  + +DG +Y+ +  F+
Sbjct: 359 AVRL-ACESVSTRAAIMCSAGLAGILNRMRQSR----REELLRITVGVDGSVYKLHPSFK 413

Query: 461 TCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505
               AT+  L    +   +    + +GSG GAAL++A   + A +
Sbjct: 414 DKFHATVLKLT---SGCEITFIQSEEGSGRGAALISAVAYKMAVM 455


>4DCH-A nrPDB
          Length = 473

 Score =  576 bits (1484), Expect = e-165,   Method: Composition-based stats.
 Identities = 162/478 (33%), Positives = 250/478 (52%), Gaps = 29/478 (6%)

Query: 39  EERRRRAAAV---IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYV 93
           ++R R  AA    +E++   F      L+ +   M +EM+RGLR + H  A +KML +YV
Sbjct: 3   DDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYV 62

Query: 94  DNLPTGDEHGLFYALDLGGTNFRVIRVQLGGR--EKRVVSQQYEEVAIPPHLMVGTSMEL 151
            + P G E G F +LDLGGTNFRV+ V++G     +  V  +++  +IP   M GT+  L
Sbjct: 63  RSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEML 122

Query: 152 FDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTV 211
           FD+I+  +  F+     D H  + ++  LGFTFSFPV    I  G L+ WTKGF  +G  
Sbjct: 123 FDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAE 177

Query: 212 GEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEH 270
           G +VV  L  A++R+G  +M V A+VNDTV T+    Y D+     +I+GTG NA Y+E 
Sbjct: 178 GNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEE 237

Query: 271 ANAIPKWTGLLPRSGNMVINMEWGNFKSERLP---RSDYDNALDFESLNPGEQIYEKMIS 327
              +    G     G M +N EWG F           +YD  +D  S NPG+Q+YEK+I 
Sbjct: 238 MQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIG 294

Query: 328 GMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLK 387
           G Y+GE+VR +LL+L  +  LF      +L  R    T  +S +  DT  D K +   L 
Sbjct: 295 GKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNIL- 352

Query: 388 DILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIA 447
             LG+  ++ +   I    C+ V+ R A + +AG+ G++ ++   R         R  + 
Sbjct: 353 STLGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVG 407

Query: 448 LDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505
           +DG +Y+ +  F+    A++  L     +  +    + +GSG GAAL++A   + A +
Sbjct: 408 VDGSVYKLHPSFKERFHASVRRLT---PSCEITFIESEEGSGRGAALVSAVACKKACM 462


>3HM8-A nrPDB
          Length = 445

 Score =  568 bits (1464), Expect = e-162,   Method: Composition-based stats.
 Identities = 169/462 (36%), Positives = 251/462 (54%), Gaps = 27/462 (5%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYA 107
           ++EE    F      L  +   M + M +GLR +  + L+ML ++V   P G E G F A
Sbjct: 5   LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA-SSLRMLPTFVRATPDGSERGDFLA 63

Query: 108 LDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEG 167
           LDLGGTNFRV+ V++       V    E  +IP  +  G+  +LFD I   +  F + +G
Sbjct: 64  LDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQG 119

Query: 168 EDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQ- 226
                  G+   LGFTFSFP  Q  +  G L+ WTKGF  +   G+DVV+ L  A+ R+ 
Sbjct: 120 -----LSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQ 174

Query: 227 GLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGN 286
            +++ V A+VNDTVGT+    Y D      +I+GTGTNA Y+E    +    G+   SG 
Sbjct: 175 AVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNV---AGVPGDSGR 231

Query: 287 MVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLA 343
           M INMEWG F  +    +  + +D ++D  S+NPG+Q +EKMISGMYLGEIVR ILL L 
Sbjct: 232 MCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLT 291

Query: 344 HDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYIT 403
               LF      +L+ R I +T  +S +  D S  L+ + A L+D LG+  TS +   + 
Sbjct: 292 SLGVLFRGQQIQRLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTS-DDALMV 348

Query: 404 LHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCL 463
           L VC  V++R A+L  AG+  +++K+  +R    G ++    + +DG LY+ + +F + +
Sbjct: 349 LEVCQAVSQRAAQLCGAGVAAVVEKIRENR----GLEELAVSVGVDGTLYKLHPRFSSLV 404

Query: 464 EATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 505
            AT+ +L        V    + DGSG GAAL+ A   + A +
Sbjct: 405 AATVREL---APRCVVTFLQSEDGSGKGAALVTAVACRLAQL 443


>1IG8-A nrPDB
          Length = 486

 Score =  567 bits (1461), Expect = e-162,   Method: Composition-based stats.
 Identities = 155/472 (32%), Positives = 240/472 (50%), Gaps = 34/472 (7%)

Query: 29  RRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKM 88
           ++ ++++ +  +  +     IE  E+ F+ PT  L+ +    + E+E+GL +     + M
Sbjct: 7   KKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGL-SKKGGNIPM 65

Query: 89  LISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS 148
           +  +V + PTG E G F A+DLGGTN RV+ V+LGG      +Q    +   P  M  T 
Sbjct: 66  IPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQ 122

Query: 149 --MELFDFIAAELESFVKTEGEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKG 204
              EL++FIA  L++F+     D   P+G      LGFTFSFP  Q  I+ G L +WTKG
Sbjct: 123 NPDELWEFIADSLKAFI-----DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKG 177

Query: 205 FSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTN 264
           F I      DVV  L + + ++ + ++V AL+NDT GTL    Y D +    VI GTG N
Sbjct: 178 FDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVN 237

Query: 265 AAYVEHANAIPKWTGLL----PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPG 318
            AY +  + I K  G L    P S  M IN E+G+F +E   LPR+ YD  +D ES  PG
Sbjct: 238 GAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPG 297

Query: 319 EQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHD 378
           +Q +EKM SG YLGEI+R  L+ +     +F +   +K ++ F++ T   + +  D   +
Sbjct: 298 QQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFEN 357

Query: 379 LKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDG 438
           L+      ++  G+ +T+++ R +   + +L+  R ARL+  GI  I +K G        
Sbjct: 358 LEDTDDLFQNEFGI-NTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGY------- 409

Query: 439 SQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAAS----SVVVKLAND 486
              +   IA DG +Y  Y  F+      L D+ G    S     + +  A D
Sbjct: 410 ---KTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAED 458


>3B8A-X nrPDB
          Length = 485

 Score =  558 bits (1437), Expect = e-159,   Method: Composition-based stats.
 Identities = 163/484 (33%), Positives = 249/484 (51%), Gaps = 29/484 (5%)

Query: 29  RRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKM 88
           ++ ++++ +  +  +     I ++E  F+  +  LR +    ++E+ +GL       + M
Sbjct: 7   KKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGL-TKKGGNIPM 65

Query: 89  LISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGT- 147
           +  +V   PTG E G + A+DLGGTN RV+ V+L G      +Q   ++   PH M  T 
Sbjct: 66  IPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKL---PHDMRTTK 122

Query: 148 -SMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFS 206
              EL+ FIA  L+ F+  E E  +  +     LGFTFS+P  Q  I+ G L +WTKGF 
Sbjct: 123 HQEELWSFIADSLKDFM-VEQELLNTKD--TLPLGFTFSYPASQNKINEGILQRWTKGFD 179

Query: 207 INGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAA 266
           I    G DVV  L   + ++ L +++ AL+NDTVGTL    Y D +    VI GTG N A
Sbjct: 180 IPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGA 239

Query: 267 YVEHANAIPKWTGLL----PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQ 320
           + +  + I K  G L    P +  M IN E+G+F +E   LPR+ YD A+D +S  PG+Q
Sbjct: 240 FYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQ 299

Query: 321 IYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLK 380
            +EKM SG YLGE++R +LL+L     +  D   +KL+Q +I+ T   + +  D   +L+
Sbjct: 300 AFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLE 359

Query: 381 HLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQ 440
                 +   GV  T+L  R +   +C+L+  R ARLA  GI  I +K G          
Sbjct: 360 DTDDIFQKDFGVK-TTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGY--------- 409

Query: 441 KQRTVIALDGGLYEHYKKFRTCLEATLADLLGEE---AASSVVVKLANDGSGIGAALLAA 497
            +   IA DG +Y  Y  F+      L D+ G     +   + +  A DGSG GAA++AA
Sbjct: 410 -KTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAA 468

Query: 498 SHSQ 501
              +
Sbjct: 469 LSEK 472


>1BDG-A nrPDB
          Length = 451

 Score =  548 bits (1413), Expect = e-156,   Method: Composition-based stats.
 Identities = 166/459 (36%), Positives = 249/459 (54%), Gaps = 25/459 (5%)

Query: 48  VIEEVEQRFSTPTALLRGIADAMVEEMERGLR--ADPHAPLKMLISYVDNLPTGDEHGLF 105
            + E+ + F         I D M E M  GL+   +  + +KM  SYV   P G E G F
Sbjct: 11  KVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNF 70

Query: 106 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 165
            ALDLGGTN+RV+ V L G+ K    Q+     IP   M G+  ELF +IA  L  F++ 
Sbjct: 71  LALDLGGTNYRVLSVTLEGKGKSPRIQE-RTYCIPAEKMSGSGTELFKYIAETLADFLEN 129

Query: 166 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 225
            G      + ++ +LGFTFSFP  Q  ++  TL++WTKGFS +G  G +V   L   +++
Sbjct: 130 NG-----MKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDK 184

Query: 226 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 285
           + L++K  A+VNDTVGTLA     D   A  +I+GTGTN AY+E ++ +    G+  +  
Sbjct: 185 RELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV--KEP 242

Query: 286 NMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 342
            +VIN EWG F  +      R+ +D ++D +SL+PG+Q+YEKM+SGMYLGE+VR I++ L
Sbjct: 243 EVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYL 302

Query: 343 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 402
                LF   +P +L+ R  L T  ++ +  D +H L +    L D L V         I
Sbjct: 303 VEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRI 362

Query: 403 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 462
             + C++V +R A LA AGI  IL+++ R              + +DG LY+ + KF   
Sbjct: 363 VRYACEMVVKRAAYLAGAGIACILRRINRSE----------VTVGVDGSLYKFHPKFCER 412

Query: 463 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQ 501
           +   +  L  +   +   ++L+ DGSG GAA +AAS ++
Sbjct: 413 MTDMVDKL--KPKNTRFCLRLSEDGSGKGAAAIAASCTR 449


>2YHX-A nrPDB
          Length = 457

 Score =  139 bits (350), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 85/464 (18%), Positives = 152/464 (32%), Gaps = 36/464 (7%)

Query: 47  AVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFY 106
           +++E     F  P  +L+ +   +             A + M+  +V    +G + G F 
Sbjct: 7   SLVEVHXXVFIVPPXILQAVVSILTT--RXDDXDSSAASIPMVPGWVLKQVSGAQAGSFL 64

Query: 107 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS--MELFDFIAAELESFVK 164
           A+ +GG +  VI + L GR++  +       A     M  T+   +L+   A        
Sbjct: 65  AIVMGGGDLEVILISLAGRQESSIXASRSLAA----AMSTTAIPSDLWGNXAXS----NA 116

Query: 165 TEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 224
                          LGFTF     +  +  G +      FS+       +++ +  A  
Sbjct: 117 AFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLX--KLISAMXNAXF 174

Query: 225 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAI--PKWTGLLP 282
             G      A + D+ G L    Y D  +   +I G+G NAAY   +  I      G   
Sbjct: 175 PAGDXXXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIGDAADGGXXG 234

Query: 283 RSGNMVINMEWGNFKSE--RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILL 340
            +G M I  +  +F+     LP+  Y   L+  S    +  + K       G+ +R +L+
Sbjct: 235 GAGXMXICCDQSSFRKAFPSLPQIXYLXTLNXXSPXAXK-TFXKNSXAKNXGQSLRDVLM 293

Query: 341 KLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEAR 400
                                +  T   + +      DL+          G+A  +   +
Sbjct: 294 XFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTX-MK 351

Query: 401 YITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFR 460
            +      L+A    RL    I  I +K G               IA  G     Y  F 
Sbjct: 352 XVVRRXLFLIAAYAFRLVVCXIXAICQKKGYS----------SGHIAAXGSX-RSYSGFS 400

Query: 461 TCLEATLADLLGEEA----ASSVVVKLANDGSGIGAALLAASHS 500
                   ++ G       +  + +  A DG G  + ++ +  S
Sbjct: 401 XNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIAS 444


>1HKG-A nrPDB
          Length = 457

 Score =  135 bits (339), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 83/469 (17%), Positives = 149/469 (31%), Gaps = 36/469 (7%)

Query: 42  RRRAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDE 101
                +++E     F  P  +L+ +    +            A + M+  +V     G +
Sbjct: 2   ASXDXSLVEVHXXVFIVPPXILQAVVS--IATTRXDDXDSAAASIPMVPGWVLKQVXGSQ 59

Query: 102 HGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTS--MELFDFIAAEL 159
            G F A+ +GG +  VI + L G ++  +       A     M  T+   +L+   A   
Sbjct: 60  AGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA----SMXTTAIPSDLWGNXAXS- 114

Query: 160 ESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAEL 219
                               LGFTF     +  +  G +      FS+       +++ +
Sbjct: 115 ---NAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLX--KLISAM 169

Query: 220 SRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAI--PKW 277
             A    G      A + D+ G L    Y D  +   +I G+G NAAY   +  I     
Sbjct: 170 XNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIADAAD 229

Query: 278 TGLLPRSGNMVINMEWGNFKSE--RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIV 335
            G    +G M +     +F+     LP+  Y   L+  S    +  +EK       G+ +
Sbjct: 230 AGXXGGAGXMXVCCXQDSFRKAFPSLPQIXYXXTLNXXSPXAXK-TFEKNSXAKNXGQSL 288

Query: 336 RRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADT 395
           R +L+                     +  +   + +      DL+          G+A  
Sbjct: 289 RDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXK 347

Query: 396 SLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEH 455
           +   + +      L+A    RL    I  I +K G               IA  G     
Sbjct: 348 TX-MKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYS----------SGHIAAXGSX-RD 395

Query: 456 YKKFRTCLEATLADLLGEEA----ASSVVVKLANDGSGIGAALLAASHS 500
           Y  F         ++ G       +  + +  A DG G    ++ +  S
Sbjct: 396 YSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIAS 444


>1Q1R-A nrPDB
          Length = 431

 Score = 28.8 bits (63), Expect = 4.9,   Method: Composition-based stats.
 Identities = 11/42 (26%), Positives = 14/42 (33%)

Query: 244 AGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 285
               Y      A V + TGT     E +    K T +L   G
Sbjct: 193 VSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDG 234


>1E19-A nrPDB
          Length = 314

 Score = 28.8 bits (63), Expect = 6.0,   Method: Composition-based stats.
 Identities = 19/146 (13%), Positives = 45/146 (30%), Gaps = 20/146 (13%)

Query: 116 RVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEG 175
           RV+ + LGG   +   Q+     +  ++           IA  +    +      + P+ 
Sbjct: 4   RVV-IALGGNALQQRGQKGSYEEMMDNVRKTARQ-----IAEIIARGYEVVITHGNGPQV 57

Query: 176 RQRELGF-----TFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQGLDM 230
               L       T+  P     ++      W         +G  +   L   + ++G++ 
Sbjct: 58  GSLLLHMDAGQATYGIPAQPMDVAGAMSQGW---------IGYMIQQALKNELRKRGMEK 108

Query: 231 KVTALVNDTVGTLAGGRYVDNDVAAA 256
           KV  ++  T+       + +      
Sbjct: 109 KVVTIITQTIVDKNDPAFQNPTKPVG 134


>6MU0-A nrPDB
          Length = 160

 Score = 28.8 bits (63), Expect = 6.1,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 27/72 (37%), Gaps = 4/72 (5%)

Query: 6   VVGTAVVVCAAAAAAVGVAVVVSRRRRSKREAEEERRRRAAAVIEEVEQRFSTPTALLRG 65
           + GT V VC AA    GV   +    ++   A +            +  RF T +  ++ 
Sbjct: 76  ICGTGVGVCMAANKVKGVLAALVVSEKTAALARQHDNANVLC----LSSRFVTDSENIKI 131

Query: 66  IADAMVEEMERG 77
           + D +    E G
Sbjct: 132 VDDFLKANFEGG 143


>2WD5-A nrPDB
          Length = 233

 Score = 28.5 bits (62), Expect = 7.9,   Method: Composition-based stats.
 Identities = 31/154 (20%), Positives = 57/154 (37%), Gaps = 17/154 (11%)

Query: 302 PRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRF 361
           P S Y   +D     P ++ Y+  ++   LG+ +  I++          D +    EQR 
Sbjct: 52  PGSVYGRLIDL--CQPTQKKYQIAVT-KVLGKNMDAIIVDSEKTG---RDCIQYIKEQRG 105

Query: 362 ILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAG 421
              T            ++K    KL+++ G        RY   H+      + A   A G
Sbjct: 106 EPETFLPLD-----YLEVKPTDEKLRELKGAKLVIDVIRYEPPHI------KKALQYACG 154

Query: 422 IYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEH 455
              +   +   R  + G  ++   +ALDG L++ 
Sbjct: 155 NALVCDNVEDARRIAFGGHQRHKTVALDGTLFQK 188


>2BWY-A nrPDB
          Length = 440

 Score = 28.5 bits (62), Expect = 8.0,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 41/116 (35%), Gaps = 31/116 (26%)

Query: 258 ILGTGTNAAYVEHANA-IPKWTG--LLPRSGNMVINMEWGNFKSE------------RLP 302
           I+G+G N   + +         G  +L  +G      E+  +  +            +  
Sbjct: 232 IVGSGENGCILHYTENECEMRDGDLVLIDAG-----CEYKGYAGDITRTFPVNGKFTQAQ 286

Query: 303 RSDYDNALD--FESLN---PGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVV 353
           R  YD  L+    SL    PG  I E        GE+VR ++  L     L GDV 
Sbjct: 287 REIYDIVLESLETSLRLYRPGTSILE------VTGEVVRIMVSGLVKLGILKGDVD 336


>1Q5D-A nrPDB
          Length = 419

 Score = 28.1 bits (61), Expect = 9.7,   Method: Composition-based stats.
 Identities = 31/178 (17%), Positives = 59/178 (33%), Gaps = 16/178 (8%)

Query: 202 TKGFSINGTVGEDVVAELSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGT 261
           TK    + T G  ++  +     R  L+  V  ++       +     +       I+  
Sbjct: 195 TKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAA 254

Query: 262 GTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQI 321
           GT+      A A+     L       ++  E G  ++       +DN L   ++    Q 
Sbjct: 255 GTDTTIYLIAFAVLNL--LRSPEALELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQD 312

Query: 322 YEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDL 379
            E   + +  GE+V  ++              P+ L    +   PD+  +  DTS  L
Sbjct: 313 LEYCGASIKKGEMVFLLI--------------PSALRDGTVFSRPDVFDVRRDTSASL 356


  Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta
    Posted date:  Jan 3, 2023  9:05 PM
  Number of letters in database: 10,336,785
  Number of sequences in database:  36,641
  
Lambda     K      H
   0.316    0.137    0.370 

Lambda     K      H
   0.267   0.0416    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,971,226
Number of Sequences: 36641
Number of extensions: 791088
Number of successful extensions: 2499
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2261
Number of HSP's gapped (non-prelim): 63
length of query: 506
length of database: 10,336,785
effective HSP length: 101
effective length of query: 405
effective length of database: 6,636,044
effective search space: 2687597820
effective search space used: 2687597820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)