BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q8A1G3 (692 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3K8L-A nrPDB 1384 0.0 1WZA-A nrPDB 140 2e-33 5ZCD-A nrPDB 130 2e-30 5M99-B nrPDB 128 1e-29 2ZE0-A nrPDB 126 3e-29 5WCZ-A nrPDB 125 9e-29 4AIE-A nrPDB 122 5e-28 5H2T-A nrPDB 122 6e-28 2ZIC-A nrPDB 120 2e-27 5BRQ-A nrPDB 120 2e-27 1UOK-A nrPDB 120 2e-27 4LXF-A nrPDB 120 3e-27 3WY1-A nrPDB 120 3e-27 3GBE-A nrPDB 119 3e-27 4HOX-A nrPDB 119 3e-27 5DO8-B nrPDB 119 4e-27 5X7U-A nrPDB 117 2e-26 3ZO9-A nrPDB 116 3e-26 4GI8-A nrPDB 116 4e-26 1M53-A nrPDB 113 3e-25 5YKB-A nrPDB 108 9e-24 3AXH-A nrPDB 104 1e-22 1LWJ-A nrPDB 102 4e-22 5BN7-A nrPDB 97 2e-20 5A2B-A nrPDB 97 3e-20 4E2O-A nrPDB 97 3e-20 5OT1-A nrPDB 94 1e-19 4AEE-A nrPDB 93 4e-19 1JL8-A nrPDB 92 6e-19 4AEF-A nrPDB 89 6e-18 1EA9-C nrPDB 85 1e-16 6A0L-A nrPDB 80 2e-15 5Z0U-A nrPDB 79 6e-15 1SMA-A nrPDB 78 1e-14 1J0H-A nrPDB 78 2e-14 1QHO-A nrPDB 76 4e-14 2Z1K-A nrPDB 75 7e-14 2WC7-A nrPDB 75 8e-14 3HJE-A nrPDB 75 9e-14 3UER-A nrPDB 74 2e-13 5ZCR-A nrPDB 71 2e-12 1CYG-A nrPDB 70 2e-12 4CGT-A nrPDB 70 2e-12 3UEQ-A nrPDB 70 4e-12 3VM7-A nrPDB 69 8e-12 6AIJ-A nrPDB 69 1e-11 3EDF-A nrPDB 68 2e-11 3DHU-A nrPDB 67 2e-11 4JCM-A nrPDB 67 2e-11 5H05-A nrPDB 67 3e-11 1EO7-A nrPDB 67 4e-11 3CZE-A nrPDB 66 4e-11 4AYS-A nrPDB 66 4e-11 6IRT-A nrPDB 64 2e-10 1EHA-A nrPDB 63 3e-10 2DH2-A nrPDB 63 3e-10 1V3M-A nrPDB 63 5e-10 1A47-A nrPDB 63 5e-10 2WPG-A nrPDB 62 6e-10 1IV8-A nrPDB 60 4e-09 2TAA-A nrPDB 57 2e-08 4GKL-A nrPDB 52 1e-06 5CIM-A nrPDB 51 2e-06 2AAA-A nrPDB 51 2e-06 4OKD-A nrPDB 48 1e-05 4CN6-A nrPDB 48 1e-05 4U33-A nrPDB 46 6e-05 1BF2-A nrPDB 43 4e-04 2BHU-A nrPDB 43 4e-04 4UZU-A nrPDB 43 4e-04 3M07-A nrPDB 43 4e-04 3BH4-A nrPDB 43 6e-04 2YA2-A nrPDB 42 6e-04 1E3X-A nrPDB 42 7e-04 2D3L-A nrPDB 42 7e-04 1MXD-A nrPDB 42 0.001 3K1D-A nrPDB 42 0.001 2DIE-A nrPDB 42 0.001 1BPL-A nrPDB 41 0.001 1BLI-A nrPDB 41 0.001 6GXV-A nrPDB 41 0.002 2GJP-A nrPDB 40 0.004 3BCF-A nrPDB 40 0.004 1UA7-A nrPDB 39 0.010 5GQY-A nrPDB 39 0.010 2VNC-A nrPDB 38 0.013 3QGV-A nrPDB 38 0.017 1UD8-A nrPDB 37 0.025 5E70-A nrPDB 37 0.026 3AMK-A nrPDB 37 0.032 3FAW-A nrPDB 37 0.034 1MFU-A nrPDB 37 0.038 3L2M-A nrPDB 36 0.046 3DC0-A nrPDB 36 0.046 3WN6-A nrPDB 36 0.060 6JEQ-A nrPDB 35 0.093 1AVA-A nrPDB 35 0.099 3WDH-A nrPDB 35 0.11 3BSH-A nrPDB 35 0.16 2WSK-A nrPDB 34 0.18 5CLW-A nrPDB 34 0.19 3THX-B nrPDB 34 0.20 1TMQ-A nrPDB 33 0.54 5J6H-A nrPDB 32 0.86 5JBE-A nrPDB 32 1.3 6MDV-A nrPDB 31 1.9 5N4B-A nrPDB 31 2.0 2X7Q-A nrPDB 31 2.2 3VM5-A nrPDB 31 2.3 2E8Y-A nrPDB 30 2.8 5FR8-A nrPDB 30 4.7 6MRE-A nrPDB 29 5.3 5C8B-B nrPDB 29 6.8 >3K8L-A nrPDB Length = 669 Score = 1384 bits (3583), Expect = 0.0, Method: Compositional matrix adjust. Identities = 668/669 (99%), Positives = 669/669 (100%) Query: 24 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN 83 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN Sbjct: 1 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN 60 Query: 84 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG 143 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG Sbjct: 61 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG 120 Query: 144 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY 203 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY Sbjct: 121 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY 180 Query: 204 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE 263 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE Sbjct: 181 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE 240 Query: 264 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT 323 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT Sbjct: 241 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT 300 Query: 324 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD 383 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD Sbjct: 301 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD 360 Query: 384 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY 443 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY Sbjct: 361 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY 420 Query: 444 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTS 503 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNH+EDRTS Sbjct: 421 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHNEDRTS 480 Query: 504 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT 563 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT Sbjct: 481 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT 540 Query: 564 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY 623 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY Sbjct: 541 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY 600 Query: 624 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY 683 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY Sbjct: 601 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY 660 Query: 684 ASVVFKLGN 692 ASVVFKLGN Sbjct: 661 ASVVFKLGN 669 >1WZA-A nrPDB Length = 488 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 70/137 (51%), Positives = 86/137 (62%), Gaps = 9/137 (6%) Query: 64 YQLLLYSFADSDGDGYGDLNGVTQKLDYLNQ--------LGVKALWLSPIHPCMSYHGYD 115 Y++ + SF DSDGDG GDL G+ +KLDYLN LGV +WL PI SYHGYD Sbjct: 8 YEIFVRSFYDSDGDGIGDLKGIIEKLDYLNDGDPETIADLGVNGIWLMPIFKSPSYHGYD 67 Query: 116 VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRN 175 VTDY K+NP GT DF +LV AH RGIK+ +D +NHT HPWF +AS S YR+ Sbjct: 68 VTDYYKINPDYGTLEDFHKLVEAAHQRGIKVIIDLPINHTSERHPWFLKASRDKNSEYRD 127 Query: 176 YYSFSEDPKTDIAAGKI 192 YY ++ P TD K+ Sbjct: 128 YYVWA-GPDTDTKETKL 143 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 93/348 (26%), Positives = 156/348 (44%), Gaps = 38/348 (10%) Query: 352 DLNYGPVDQAGESPAYQ-AIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFY 410 DLNY +P Q + AK W+ +GVDG RLD HI+ ++N + + F Sbjct: 167 DLNY-------NNPEVQEKVIGIAKYWLKQGVDGFRLDGAMHIFPPAQYDKNFTWWEKFR 219 Query: 411 EDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYF 470 +++ Y++GEV + VAPY+K F+ +F ++L + + F Sbjct: 220 QEIE-------EVKPVYLVGEVWDISETVAPYFK---YGFDSTFNFKLAEAVIATAKAGF 269 Query: 471 -------AKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTS 523 AK I + + +YI+A L+NHD++R +LG+ +K ++AA++ LT Sbjct: 270 PFGFNKKAKHIYGVYDREVGF-GNYIDAPFLTNHDQNRILDQLGQDRNKARVAASIYLTL 328 Query: 524 AGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQAD 583 G+P+IYYGEE+G+ G + E +R P W + T A + +V ++ + Sbjct: 329 PGNPFIYYGEEIGMRGQGPH--EVIREPFQWYNGSGEGETYWEPAMYNDGFTSVEQEEKN 386 Query: 584 THSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 SLLN Y L RN P G K + N + A+ D L V HN Sbjct: 387 LDSLLNHYRRLIHFRNENPVFYTG---KIEIINGGLN-----VVAFRRYNDKRDLYVYHN 438 Query: 644 FGGTAMQLPLTDKIEKVLFVNG--ETQQNTDSDSYTLKLGGYASVVFK 689 +++ + +LF +G E D++ + Y ++V + Sbjct: 439 LVNRPVKIKVASGNWTLLFNSGDKEITPVEDNNKLMYTIPAYTTIVLE 486 >5ZCD-A nrPDB Length = 555 Score = 130 bits (327), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 57/121 (47%), Positives = 83/121 (68%), Gaps = 1/121 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HGYDVTDYT 120 ++YQ+ SF DS+GDG GD+ GV KLDYL+ LG+ +W+ PI+ + +GYD++DY Sbjct: 10 VAYQIYPRSFMDSNGDGIGDIQGVISKLDYLSDLGIDVIWICPIYQSPNDDNGYDISDYK 69 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 + GT DFD L+ E H+RG+K+ +D V+NHT HPWF E+ S+ E+PYR+YY + Sbjct: 70 DIMKDFGTMEDFDELLDEVHHRGMKLIMDLVINHTSDEHPWFLESRSAKENPYRDYYIWH 129 Query: 181 E 181 E Sbjct: 130 E 130 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 67/290 (23%), Positives = 108/290 (37%), Gaps = 60/290 (20%) Query: 377 WIARGVDGLRLDAVKHIYHSETSEENPRFLKMFY-EDMNAYYKQKGHTDDFYMIGE-VLS 434 W+ +G+DG R+DA+ HI + P K+ Y + + G + + E + Sbjct: 188 WLDKGIDGFRVDAISHIKKVAGFPDLPNPEKLDYVPSFEGHMNRPGIQEHLKELKEKTFA 247 Query: 435 EYDK-----------------VAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSY 477 +YD VA +F+F + G K IL+ Sbjct: 248 KYDIMTVGQANGVTSDSADEWVAEDGGNFNMIFQFEHMGLWDKGEEKPLDLIELKTILTN 307 Query: 478 QQKYANYRSDYIEATKLSNHDEDRTSSKLGKSA---DKCKLAAAVLLTSAGHPYIYYGEE 534 Q + + A L NHD+ R+ +K G +A + K AA+ G P+IY G+E Sbjct: 308 WQNGLEKINGW-NALYLENHDQIRSVNKFGSTAYRVESAKCLAALYFLMKGTPFIYQGQE 366 Query: 535 LGLYGTK-----------------------DNGDEYV-----------RSPMLWGDSYTT 560 LG+ K D+ DE + R+PM W Sbjct: 367 LGMTNVKFDSIDDYDDVGMINYYRIQREKGDSHDEIMKVIWETGRDNSRTPMQWNTEKNA 426 Query: 561 NY-TDKTDATVSKNVK--TVADQQADTHSLLNIYFSLTRLRNTYPALAEG 607 + T V+ N V +Q++D +S+LN Y L ++R + L G Sbjct: 427 GFSTGNPWMKVNPNYVDINVEEQKSDKNSVLNFYKQLIKIRKQHDVLVYG 476 >5M99-B nrPDB Length = 505 Score = 128 bits (321), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 56/120 (46%), Positives = 80/120 (66%), Gaps = 1/120 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTK 121 + Y++ + S DSDGDG GD+NGV+QK+DYL +LG+ A+W P + +SYHGYD+TDY Sbjct: 6 VVYEIFIRSLYDSDGDGVGDINGVSQKVDYLRKLGIDAVWFMPFNEAVSYHGYDITDYYN 65 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFS 180 V GT D + ++ H GIK+ +D V+NHT HPWF +A +++ SPY +YY S Sbjct: 66 VEKDYGTMEDLENMIQVLHENGIKVIMDLVINHTSDEHPWFKDAVENTTSSPYWDYYIMS 125 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 87/319 (27%), Positives = 129/319 (40%), Gaps = 77/319 (24%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHIYH---SETSEENPRFLKMFYEDMNAYYKQKGHTD 424 + + WI++GVDG R+DA KHIY + +E+ + + F + Y K Sbjct: 168 EEVKKIVDFWISKGVDGFRIDAAKHIYGWSWDDGIQESAEYFEWFRD----YVLSK--KP 221 Query: 425 DFYMIGEVLS--EYD-KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKY 481 D ++GEV S YD + P +P +F F+ Y + G Sbjct: 222 DAILVGEVFSGNTYDLSLYP----IP-VFNFALMYSIRNYPEGQDGM------------- 263 Query: 482 ANYRSDYIEAT--KLSNHDEDRTSSKLGKSADK--------CKLAAA----VLLTSAGHP 527 ++++E + L NHD R S L + K K AA ++ T G P Sbjct: 264 --IENNWVEESFLFLENHDLHRFFSHLQEHYKKFSESDYEFIKKRAALWYFLIFTLKGSP 321 Query: 528 YIYYGEELGLYGTKDNG---DEYVRSPMLW-------GDSYTTNYTDKTDATVSKNVK-- 575 IYYG E+G G K +G DE VR PM W G ++ T K N Sbjct: 322 VIYYGGEIGTRGFKWHGPVYDEPVREPMQWYASGTGEGQTFWTKEVYKNAGITFGNADVD 381 Query: 576 -----------TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYK 624 +V +Q+ D SLLN + R + A+ G+ T +D+K Sbjct: 382 GCIYDDPYDGFSVEEQENDPKSLLNFIRFILNFRKDHDAILNGDQTIF--------RDWK 433 Query: 625 PIAAWYMTKDNEKLLVIHN 643 + A+Y NEKLLV+ N Sbjct: 434 NLIAFYRESSNEKLLVVLN 452 >2ZE0-A nrPDB Length = 555 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 55/121 (45%), Positives = 84/121 (69%), Gaps = 1/121 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HGYDVTDYT 120 ++YQ+ SF D++GDG GDL G+ +KLDYL +LGV +W+ PI+ + +GYD++DY Sbjct: 10 VAYQIYPRSFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNADNGYDISDYY 69 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 + + GT DFD L+ +AH RG+K+ LD V+NHT HPWF E+ SS ++P R++Y + Sbjct: 70 AIMDEFGTMDDFDELLAQAHRRGLKVILDLVINHTSDEHPWFIESRSSRDNPKRDWYIWR 129 Query: 181 E 181 + Sbjct: 130 D 130 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 66/296 (22%), Positives = 106/296 (35%), Gaps = 64/296 (21%) Query: 364 SPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEE--NPRFLKMFYEDMNAYYKQKG 421 S QA+ + W+ +G+DG R+DA+ HI + NP+ LK + + Q G Sbjct: 175 SEVRQALYEMVNWWLDKGIDGFRIDAISHIKKKPGLPDLPNPKGLK-YVPSFAGHMNQPG 233 Query: 422 HTD-------------DFYMIGEVLSEYDKVAPYYKG-----LPALFEFSFWYRLEWGIN 463 + D +GE A + G +F+F E + Sbjct: 234 IMEYLRELKEQTFARYDIMTVGEANGVTVDEAEQWVGEENGVFNMIFQFEHLGLWERRAD 293 Query: 464 NSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKS----ADKCKLAAAV 519 S K L+ QK R A L NHD R+ S G A+ K A+ Sbjct: 294 GSIDVRRLKRTLTKWQKGLENRG--WNALFLENHDLPRSVSTWGNDRDYWAESAKALGAL 351 Query: 520 LLTSAGHPYIYYGEELGLYGTK----------------------------------DNGD 545 G P+IY G+E+G+ + G Sbjct: 352 YFFMQGTPFIYQGQEIGMTNVRFDDIRDYRDVSALRLYELERAKGRTHEEAMTIIWKTGR 411 Query: 546 EYVRSPMLWGDSYTTNYTDKTD-ATVSKNVKT--VADQQADTHSLLNIYFSLTRLR 598 + R+PM W + +T T V++N +T V ++ D +S+ + Y + +LR Sbjct: 412 DNSRTPMQWSGASNAGFTTGTPWIKVNENYRTINVEAERRDPNSVWSFYRQMIQLR 467 >5WCZ-A nrPDB Length = 586 Score = 125 bits (313), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 58/126 (46%), Positives = 82/126 (65%), Gaps = 2/126 (1%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVTDYT 120 + YQ+ SF D++GDG+GDL GV QKLDY+ LG +WLSP+ +GYD++DY Sbjct: 34 VVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGADVIWLSPVFDSPQDDNGYDISDYK 93 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 + + GT D +L+ E H RG+KI +D V+NHT H WF E+ S ++PYR+YY + Sbjct: 94 NMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNHTSDEHAWFAESRKSKDNPYRDYYLW- 152 Query: 181 EDPKTD 186 +DPK D Sbjct: 153 KDPKPD 158 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 88/387 (22%), Positives = 146/387 (37%), Gaps = 89/387 (22%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHI--------YHSETSEE---------NPRFLKMFY 410 + + D + W+ RGVDG R+D + I Y ++ S PR L F Sbjct: 204 REVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHSRSYIVGRYHSNGPR-LHEFI 262 Query: 411 EDMNAYYKQKGHTDDFYMIGEVL-SEYDKVAPY----YKGLPALFEFSFWYRLEWGINNS 465 ++MN ++ D +GE S+ ++ Y + L +F F ++ N+ Sbjct: 263 QEMN---REVLSHYDCMTVGEANGSDIEEAKKYTDASRQELNMIFTFEH-MDIDKEQNSP 318 Query: 466 TGCYFAK--DILSYQQKYANYRSDYIEA----TKLSNHDEDRTSSKLG---KSADKC-KL 515 G + K D+++ ++ +++ + NHD+ R S+ G K +C K Sbjct: 319 NGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQPRVISRWGNDRKLRKECAKA 378 Query: 516 AAAVLLTSAGHPYIYYGEELGLYGTK---------------------------------- 541 A VL G P+IY GEE+G+ + Sbjct: 379 FATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKNAYRELVVENKTMSEKEFVKAV 438 Query: 542 -DNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVK----TVADQQADTHSLLNIYFSLTR 596 G ++ R+PM W +T D + N + V + D S+ Y L + Sbjct: 439 MIKGRDHARTPMQWDAGKHAGFT-AGDPWIPVNSRYQDINVKESLEDQDSIFFYYQKLIQ 497 Query: 597 LRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFG--GTAMQLP-- 652 LR Y + G+ Y QE D + + ++ EKLLV+ N + P Sbjct: 498 LRKQYKIMIYGD------YQLLQENDPQ-VFSYLREYRGEKLLVVVNLSEEKALFEAPPE 550 Query: 653 LTDKIEKVLFVNGETQQNTDSDSYTLK 679 L + KVL N Q+ D S +LK Sbjct: 551 LIHERWKVLISN-YPQERADLKSISLK 576 >4AIE-A nrPDB Length = 549 Score = 122 bits (306), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 56/123 (45%), Positives = 81/123 (65%), Gaps = 2/123 (1%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HGYDVTDYT 120 + YQ+ SF DS+GDG GDL G+ +LDYL +LG+ A+WLSP++ +GYD++DY Sbjct: 11 VVYQVYPKSFQDSNGDGIGDLQGIISRLDYLEKLGIDAIWLSPVYQSPGVDNGYDISDYE 70 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 ++PQ GT +D D L+++A IKI +D V+NHT H WF EA ++ YR+YY + Sbjct: 71 AIDPQYGTMADMDELISKAKEHHIKIVMDLVVNHTSDQHKWFVEAKKGKDNQYRDYYIW- 129 Query: 181 EDP 183 DP Sbjct: 130 RDP 132 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 85/379 (22%), Positives = 145/379 (38%), Gaps = 80/379 (21%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHS--ET 398 ++ HF D DLN+ + Q I + W+ +G+ G R+D ++ I + Sbjct: 159 YYLHFFADQQPDLNWQ------NTELRQKIYNMMNFWLDKGIGGFRMDVIELIGKDPDKN 212 Query: 399 SEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRL 458 EN L + ++MN K D +GE + K+A Y P E S ++ Sbjct: 213 IRENGPMLHPYLQEMN---KATFGKRDVMTVGETWNATPKIAEEYSD-PDRHELSMVFQF 268 Query: 459 E------------WGINNSTGCYFAKDILSYQQKYANYRSDYIEATK---LSNHDEDRTS 503 E W + K ++ +Q K D+ A NHD R Sbjct: 269 ENQSLDQQPGKEKWDLKPLDLGELKKVLVKWQTKI-----DFDHAWNSLFWENHDIPRVI 323 Query: 504 SKLGKSAD---KC-KLAAAVLLTSAGHPYIYYGEELGL---------------------- 537 S+ G + +C K+ A +L G PYI+ GEE+G+ Sbjct: 324 SRWGNDQEYRVQCAKMFAIILHMMHGTPYIFNGEEIGMTNCPVKNIDEVEDIESINMYNE 383 Query: 538 ------------YGTKDNGDEYVRSPMLWGDSYTTNYTDKTD-ATVSKNVK--TVADQQA 582 + G + R PM W D +++ +V+ N K V + A Sbjct: 384 RLAEGYDEEELIHAINVKGRDNARRPMQWNDEKNAGFSEVDPWLSVNPNYKDINVENALA 443 Query: 583 DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIH 642 D +S+ Y L +LR+ P + +G+ S+ + +Q+ + A+Y +++K LV+ Sbjct: 444 DPNSIFYTYQKLIKLRHENPIVVDGDF---SLVSNTQDA----VLAYYRILNDKKWLVVA 496 Query: 643 NFGGTAMQLPLTDKIEKVL 661 N D+IE +L Sbjct: 497 NLSNEEQNFVSNDQIETIL 515 >5H2T-A nrPDB Length = 601 Score = 122 bits (305), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 59/139 (42%), Positives = 85/139 (61%), Gaps = 8/139 (5%) Query: 51 PDTWDETKRAD-------ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLS 103 PDT+ K D + Y++L+ F+DS+ DG GDL G+ +LDYL LG+ +WL Sbjct: 9 PDTFTHEKPRDPYWYKHAVFYEVLVRGFSDSNDDGTGDLRGLINRLDYLQWLGIDCIWLL 68 Query: 104 PIHPC-MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWF 162 PI+ + GYD++DYTK+ P+ G DF LV EAH RGI++ D VMNHT HPWF Sbjct: 69 PIYQSPLRDGGYDISDYTKILPEFGDLGDFVELVDEAHRRGIRVIADLVMNHTSDQHPWF 128 Query: 163 TEASSSSESPYRNYYSFSE 181 + + + PY ++Y +S+ Sbjct: 129 QASRTDPDGPYGDFYMWSD 147 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 85/360 (23%), Positives = 144/360 (40%), Gaps = 81/360 (22%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPAYQ-AIADAAKGWIARGVDGLRLDAVKHIYHSE- 397 Y+H F DLNY ++PA Q A+ + + W+ G+DG RLDAV ++Y E Sbjct: 177 YWHRFFSHQ--PDLNY-------DNPAVQEAMLEVLRFWLDLGIDGFRLDAVPYLYAREG 227 Query: 398 TSEENPRFLKMFYEDMNAYYKQ-KGHTDDFYMIGEVLSEYDK----VAPYYKGLPAL--- 449 T+ EN + +AY K+ + D Y +L+E ++ V Y+ G PA Sbjct: 228 TNCEN-------LPETHAYLKRVRAEVDRLYPDRVLLAEANQWPADVVEYF-GDPATGGD 279 Query: 450 -----FEFSFWYRL--------------------------EWGINNSTGCYFAKDILSYQ 478 F F R+ +WGI ++++ + Sbjct: 280 ECHMAFHFPVMPRIFMAVRREQRYPISEIMAQTPKIPENCQWGIFLRNHDELTLEMVTDE 339 Query: 479 QK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEEL 535 ++ YA Y D K + R + L ++ +L A+LL+ G P +YYG+E+ Sbjct: 340 ERDYMYAEYAKD--PRMKANIGIRRRLAPLLDNDRNQLELFTALLLSLPGSPVLYYGDEI 397 Query: 536 GLYGTKDNGD-EYVRSPMLWGDSYTTNYTDKTDATVSKNV----------KTVADQQADT 584 G+ GD + VR+PM W ++ A + V V QQ + Sbjct: 398 GMGDNIWLGDRDSVRTPMQWTPDRNAGFSRCDPARLYLPVIMDPIYGYQAVNVEAQQRNP 457 Query: 585 HSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNF 644 SLLN + +R +P G+ + N S + A+ ++++L ++N Sbjct: 458 GSLLNWTRKMIEIRKRHPVFGLGSYVELPASNPS-------VLAFVREYGDDRVLCVNNL 510 >2ZIC-A nrPDB Length = 543 Score = 120 bits (302), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 57/121 (47%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Query: 64 YQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVTDYTKV 122 YQ+ SF D++GDG GDL G+T KLDYL +LGV A+WLSP++ M +GYD+ +Y + Sbjct: 12 YQIYPKSFMDTNGDGIGDLKGITSKLDYLQKLGVMAIWLSPVYDSPMDDNGYDIANYEAI 71 Query: 123 NPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSED 182 G +D D L+T+A RGIKI +D V+NHT H WF EA +S R+YY + + Sbjct: 72 ADIFGNMADMDNLLTQAKMRGIKIIMDLVVNHTSDEHAWFIEAREHPDSSERDYYIWCDQ 131 Query: 183 P 183 P Sbjct: 132 P 132 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 114/314 (36%), Gaps = 67/314 (21%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHI--YHSET 398 ++ HF + DLN+ + Q I D WI +G+ G R+D + I ++ Sbjct: 153 YYLHFFSKKQPDLNWENAN------LRQKIYDMMNFWIDKGIGGFRMDVIDMIGKIPAQH 206 Query: 399 SEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRL 458 N L + ++MNA D +GE ++A Y P E S ++ Sbjct: 207 IVSNGPKLHAYLKEMNA---ASFGQHDLLTVGETWGATPEIAKQYSN-PVNHELSMVFQF 262 Query: 459 E------------WGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSS-- 504 E W K I + Q + + +NHD R S Sbjct: 263 EHIGLQHKPEAPKWDYVKELNVPALKTIFNKWQTELELGQGW-NSLFWNNHDLPRVLSIW 321 Query: 505 -KLGKSADKCKLAAAVLL-TSAGHPYIYYGEELGL--YGTKD------------------ 542 GK +K A A+LL G PYIY GEE+G+ Y KD Sbjct: 322 GNTGKYREKSAKALAILLHLMRGTPYIYQGEEIGMTNYPFKDLNELDDIESLNYAKEAFT 381 Query: 543 --------------NGDEYVRSPMLWGDSYTTNYT--DKTDATVSKNVKTVADQQA--DT 584 G + R+PM W S ++ DKT V+ N K + Q A ++ Sbjct: 382 NGKSMETIMDSIRMIGRDNARTPMQWDASQNAGFSTADKTWLPVNPNYKDINVQAALKNS 441 Query: 585 HSLLNIYFSLTRLR 598 +S+ Y L +LR Sbjct: 442 NSIFYTYQQLIQLR 455 >5BRQ-A nrPDB Length = 568 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 52/117 (44%), Positives = 81/117 (69%), Gaps = 1/117 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVTDYT 120 + YQ+ SF D+ G+G GD+ G+ +KLDY+ +L +WL+PI+ + +GYD++DY Sbjct: 19 VVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYDISDYY 78 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYY 177 ++ + GT +DF+ L+ EAH RGIK+ +D V+NHT T H WF EA+S E+ YR++Y Sbjct: 79 SIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRDFY 135 Score = 59.3 bits (142), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 107/425 (25%), Positives = 157/425 (36%), Gaps = 101/425 (23%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETS 399 Y H + T ADLN+ ++A Y+ + W +G+DG RLD + I Sbjct: 169 YLHLYDVTQ--ADLNWE--NEAVRKKVYEMM----HFWFEKGIDGFRLDVINVI------ 214 Query: 400 EENPRFLKMFYEDMNAYYKQKGHTDDFY--MIGEVLSEYDKVA----------------- 440 ++ RF D +Y +F M EV S+YD + Sbjct: 215 SKDQRFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTN 274 Query: 441 PYYKGLPALFEFSFWYRLEWGINNSTGCYFA-------KDILSYQQKYANYRSDYIEATK 493 P + L +F F + L+ N A K ILS Q N + A Sbjct: 275 PESRELDMVFNF---HHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGW-NALF 330 Query: 494 LSNHDEDRTSSKLGKSADKCKLAAAVLLTS----AGHPYIYYGEELGLYGTK-DNGDEYV 548 NHD+ R S+ G K +A +L T+ G PYIY GEELG+ K D+ Y Sbjct: 331 WCNHDQPRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYR 390 Query: 549 ---------------------------------RSPMLWGDSYTTNYTDKTD-ATVSKNV 574 R+P+ W +T T V N Sbjct: 391 DVESLNMYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNY 450 Query: 575 KTVADQQA--DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMT 632 K + ++A D S+ Y L LR + + G+ + + QE + A+ Sbjct: 451 KEINAEEALNDPDSIFYHYKKLNELRKEFDIITTGDY--QLILEDDQE-----LYAYLRN 503 Query: 633 KDNEKLLVIHNFGGTAMQLPLTDKIE------KVLFVNGETQQNTDSDSYTLKLGGYASV 686 +EKLLVI+NF G + L D I+ KVL N +T +T+K Y S+ Sbjct: 504 GADEKLLVINNFYGKETEFQLPDDIDIEGYDAKVLISN-DTDLPESFKRFTVK--PYQSI 560 Query: 687 VFKLG 691 V+ L Sbjct: 561 VYHLA 565 >1UOK-A nrPDB Length = 558 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 53/120 (44%), Positives = 79/120 (65%), Gaps = 1/120 (0%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HGYDVT 117 + + YQ+ SF DS+GDG GDL G+ KLDYL +LG+ +WLSP++ + +GYD++ Sbjct: 7 KESVVYQIYPRSFMDSNGDGIGDLRGIISKLDYLKELGIDVIWLSPVYESPNDDNGYDIS 66 Query: 118 DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYY 177 DY K+ + GT D+D L+ E H R +K+ +D V+NHT H WF E+ S ++ YR+YY Sbjct: 67 DYCKIMNEFGTMEDWDELLHEMHERNMKLMMDLVVNHTSDEHNWFIESRKSKDNKYRDYY 126 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 94/400 (23%), Positives = 152/400 (38%), Gaps = 98/400 (24%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHIYHSE------TSEEN--------------PRFLK 407 Q + + K W+ +G+DG R+D + I E T EE ++L Sbjct: 179 QDVYEMMKFWLEKGIDGFRMDVINFISKEEGLPTVETEEEGYVSGHKHFMNGPNIHKYLH 238 Query: 408 MFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKG-----LPALFEFSFW-----YR 457 E++ ++Y D +GE+ + A Y G L +F+F Sbjct: 239 EMNEEVLSHY-------DIMTVGEMPGVTTEEAKLYTGEERKELQMVFQFEHMDLDSGEG 291 Query: 458 LEWGINNSTGCYFAKDILSYQQ--KYANYRSDYIEATKLSNHDEDRTSSKLGKSA----D 511 +W + + +++ +Q+ ++ + S Y +NHD+ R S+ G + Sbjct: 292 GKWDVKPCSLLTLKENLTKWQKALEHTGWNSLY-----WNNHDQPRVVSRFGNDGMYRIE 346 Query: 512 KCKLAAAVLLTSAGHPYIYYGEELGLYGTK-DNGDEY----------------------- 547 K+ A VL G PYIY GEE+G+ + ++ DEY Sbjct: 347 SAKMLATVLHMMKGTPYIYQGEEIGMTNVRFESIDEYRDIETLNMYKEKVMERGEDIEKV 406 Query: 548 -----------VRSPMLWGDSYTTNYTDKTD-ATVSKNVKTVADQQA--DTHSLLNIYFS 593 R+PM W D +T TV+ N K + +QA + S+ Y Sbjct: 407 MQSIYIKGRDNARTPMQWDDQNHAGFTTGEPWITVNPNYKEINVKQAIQNKDSIFYYYKK 466 Query: 594 LTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPL 653 L LR + G+ N S I A+ T EKLLVI NF L Sbjct: 467 LIELRKNNEIVVYGSYDLILENNPS-------IFAYVRTYGVEKLLVIANFTAEECIFEL 519 Query: 654 TDKI---EKVLFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 + I E L ++ +N ++ TL+ Y ++VFKL Sbjct: 520 PEDISYSEVELLIHNYDVENGPIENITLR--PYEAMVFKL 557 >4LXF-A nrPDB Length = 620 Score = 120 bits (300), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 67/158 (42%), Positives = 92/158 (58%), Gaps = 5/158 (3%) Query: 42 GQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALW 101 G AL A P TW K A + Y++L+ +F D+ DG GDL G+ +LDYL LG+ +W Sbjct: 51 GSAAALPADP-TW--FKHA-VFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIW 106 Query: 102 LSPIHPC-MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 L P + + GYD+ D+ KV P+ GT DF LV AH RGI+I D VMNHT +HP Sbjct: 107 LPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHP 166 Query: 161 WFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQE 198 WF E+ + PY +YY +S+ + A I + T+E Sbjct: 167 WFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEE 204 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 83/359 (23%), Positives = 137/359 (38%), Gaps = 76/359 (21%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPAYQ-AIADAAKGWIARGVDGLRLDAVKHIYHSE- 397 Y+H F DLNY ++PA Q A+ D + W+ G+DG RLDAV +++ E Sbjct: 217 YWHRFFSHQ--PDLNY-------DNPAVQEAMIDVIRFWLGLGIDGFRLDAVPYLFEREG 267 Query: 398 TSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVL----SEYDKVAPYYKGLP------ 447 T+ EN + +A+ K+ D G VL +++ Y G P Sbjct: 268 TNCEN-------LPETHAFLKRVRKVVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDE 320 Query: 448 --ALFEFSFWYRL--------------------------EWGINNSTGCYFAKDILSYQQ 479 F F R+ +WGI ++++ ++ Sbjct: 321 CHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEE 380 Query: 480 K---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELG 536 + YA Y D K + R + L ++ +L A+LL+ G P +YYG+E+G Sbjct: 381 RDYMYAEYAKD--PRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIG 438 Query: 537 LYGTKDNGD-EYVRSPMLWGDSYTTNYT----------DKTDATVSKNVKTVADQQADTH 585 + GD + VR PM W ++ D V Q+ + Sbjct: 439 MGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTST 498 Query: 586 SLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNF 644 SLLN ++ +R +PA A G + N S + +A D + +L ++N Sbjct: 499 SLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQVAG----DDGDTVLCVNNL 553 >3WY1-A nrPDB Length = 538 Score = 120 bits (300), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 58/130 (44%), Positives = 84/130 (64%), Gaps = 4/130 (3%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIH--PCMSYHGYDV 116 R + YQ+ SF DS GDG GDLNG+T+KLDY+ L V +WLSP P + + GYDV Sbjct: 9 RGGVIYQIYPRSFLDSRGDGVGDLNGITEKLDYVASLNVDGIWLSPFFTSPMLDF-GYDV 67 Query: 117 TDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNY 176 +DY V+P GT DF L+ +AH+ G+K+ +D V++HT HPWF E+ + +P ++ Sbjct: 68 SDYRDVDPMFGTLEDFKALLEKAHSLGLKVMIDQVISHTSDQHPWFQESRQNRTNPKADW 127 Query: 177 YSFSEDPKTD 186 + ++ DPK D Sbjct: 128 FVWA-DPKPD 136 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 98/411 (23%), Positives = 163/411 (39%), Gaps = 78/411 (18%) Query: 333 FDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKH 392 FDS++ Y+ +F T D+N+ A QA D + W+ GVDG RLD V Sbjct: 154 FDSRRQQYYLHNFLTSQ-PDVNFH------HPEARQAQLDNMRFWLDLGVDGFRLDTVNF 206 Query: 393 IYHSETSEENPRFLK-----MFYEDMNAYYKQKGHTD-------DFY------------- 427 +H +NP K + + N Y Q+ D DF Sbjct: 207 YFHDAELRDNPPVPKGEAKTLGAPEANPYTWQRHVYDLSRPENLDFLKDLRALMDEYPGT 266 Query: 428 -MIGEVLSE--YDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANY 484 +GE+ + +++A Y G L ++ + L +N + ++++ Q+ A Sbjct: 267 TTVGEIGDDNPLERMAEYTAGGDKL-HMAYTFDL---LNMPHSASYLREVIERFQRLA-- 320 Query: 485 RSDYIEATKLSNHDEDRTSSKLGKSADK---CKLAAAVLLTSAGHPYIYYGEELGL---- 537 D SNHD R++++ G D K+ AVL + G +Y GEELGL Sbjct: 321 -GDAWPCWATSNHDVVRSATRWGADEDPHAYPKVMLAVLFSLRGSVCLYQGEELGLPEAD 379 Query: 538 ---------YG----TKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVK----TVADQ 580 YG + G + R+PM W D ++ + + + V+ Q Sbjct: 380 VPFERIQDPYGKVLWPEFKGRDGCRTPMPWTDGEQGGFS-PVEPWLPMEARHLELAVSRQ 438 Query: 581 QADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLV 640 Q D ++ LN +L R ++PAL +G+++ V ++ + + K +E LL Sbjct: 439 QDDPNATLNTVRALLAFRRSHPALFDGDLSLVDVGDD--------LLGFTRQKGDETLLC 490 Query: 641 IHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 + N G Q L ++ L V T D TL L Y + ++ Sbjct: 491 VFNLTGQEQQTTLPVEVASDLPVAHFTATR---DGSTLTLPAYQAAFMQVA 538 >3GBE-A nrPDB Length = 558 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 57/135 (42%), Positives = 87/135 (64%), Gaps = 6/135 (4%) Query: 51 PDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS 110 P W E + YQ+ SF D++GDG GD+NG+ +KLDYL LG+ A+W++P + + Sbjct: 3 PKWWKEA----VFYQVYPRSFKDTNGDGIGDINGIIEKLDYLKALGIDAIWINPHYDSPN 58 Query: 111 Y-HGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS 169 +GYD+ DY K+ + GT DFDRL++E R +++ +D V+NHT + WF ++ SS Sbjct: 59 TDNGYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDVVINHTSDQNEWFVKSKSSK 118 Query: 170 ESPYRNYYSFSEDPK 184 ++PYR YY F +D K Sbjct: 119 DNPYRGYY-FWKDAK 132 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 95/387 (24%), Positives = 143/387 (36%), Gaps = 91/387 (23%) Query: 377 WIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQ--KGHTDDFY---MIGE 431 W+ +GV GLR D V T + P F + + + + + KG Y M E Sbjct: 188 WLDKGVSGLRFDTV------ATYSKIPDFPNLTQQQLKNFAAEYTKGPNIHRYVNEMNKE 241 Query: 432 VLSEYD-KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQ----------- 479 VLS YD A G+P F+ R +N F D++ + Sbjct: 242 VLSHYDIATAGEIFGVPLDQSIKFFDRRRDELN----IAFTFDLIRLDRDSDQRWRRKDW 297 Query: 480 KYANYRS--DYIEATK---------LSNHDEDRTSSKLGKSADK-----CKLAAAVLLTS 523 K + +R D ++ T L NHD R S G + K A + LT Sbjct: 298 KLSQFRQIIDNVDRTAGEYGWNAFFLDNHDNPRAVSHFGDDRPQWREPSAKALATLTLTQ 357 Query: 524 AGHPYIYYGEELGLYG------------------------TKDNGDEYV----------- 548 P+IY G ELG+ K DE++ Sbjct: 358 RATPFIYQGSELGMTNYPFKAIDEFDDIEVKGFWHDYVETGKVKADEFLQNVRLTSRDNS 417 Query: 549 RSPMLWGDSYTTNYTD-KTDATVSKNVKTV--ADQQADTHSLLNIYFSLTRLRNTYPALA 605 R+P W S +T K V+ N + + Q S+ N Y L ++R+ PAL Sbjct: 418 RTPFQWDGSKNAGFTSGKPWFKVNPNYQEINAVSQVTQPDSVFNYYRQLIKIRHDIPALT 477 Query: 606 EGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDK--IEKVLFV 663 G T N+S + A+ + EK LV+ NF M+ L D IEKV+ + Sbjct: 478 YGTYTDLDPANDS-------VYAYTRSLGAEKYLVVVNFKEQMMRYKLPDNLSIEKVI-I 529 Query: 664 NGETQQNTDSDSYTLKLGGYASVVFKL 690 + ++ + L+L + S V+KL Sbjct: 530 DSNSKNVVKKNDSLLELKPWQSGVYKL 556 >4HOX-A nrPDB Length = 559 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 54/131 (41%), Positives = 83/131 (63%), Gaps = 5/131 (3%) Query: 48 TASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 A P W + + YQ+ SF D++GDG GDLNG+ + LDYL +LG+ A+W++P + Sbjct: 1 NALPTWWKQA----VFYQVYPRSFKDTNGDGIGDLNGIIENLDYLKKLGIDAIWINPHYD 56 Query: 108 CMSY-HGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEAS 166 + +GYD+ DY K+ + GT DFDRL++E R +++ +D V+NHT H WF ++ Sbjct: 57 SPNTDNGYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDIVINHTSDQHAWFVQSK 116 Query: 167 SSSESPYRNYY 177 S +PYR+YY Sbjct: 117 SGKNNPYRDYY 127 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 101/397 (25%), Positives = 144/397 (36%), Gaps = 93/397 (23%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRF-------LKMFYEDMNAYYKQK 420 Q + D + W+ +GV GLR D V T + P F LK F E+ K Sbjct: 180 QDLYDMLRFWLDKGVSGLRFDTV------ATYSKIPNFPDLSQQQLKNFAEEYTKGPKIH 233 Query: 421 GHTDDFYMIGEVLSEYD-KVAPYYKGLPALFEFSFWYRLE-------------------- 459 + ++ M EVLS YD A G+P F+ R Sbjct: 234 DYVNE--MNREVLSHYDIATAGEIFGVPLDKSIKFFDRRRNELNIAFTFDLIRLDRDADE 291 Query: 460 -WGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADK-----C 513 W + T F K + Q Y + A L NHD R S G + Sbjct: 292 RWRRKDWTLSQFRKIVDKVDQTAGEYGWN---AFFLDNHDNPRAVSHFGDDRPQWREHAA 348 Query: 514 KLAAAVLLTSAGHPYIYYGEELGL----YGTKDNGD---------EYV------------ 548 K A + LT P+IY G ELG+ + D+ D +YV Sbjct: 349 KALATLTLTQRATPFIYQGSELGMTNYPFKKIDDFDDVEVKGFWQDYVETGKVKAEEFLQ 408 Query: 549 ----------RSPMLWGDSYTTNYTDKTD-ATVSKNVKTV--ADQQADTHSLLNIYFSLT 595 R+P W S +T T ++ N K + ADQ + +S+ N Y L Sbjct: 409 NVRQTSRDNSRTPFQWDASKNAGFTSGTPWLKINPNYKEINSADQINNPNSVFNYYRKLI 468 Query: 596 RLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQ--LPL 653 +R+ PAL G+ N S + A+ T EK LV+ NF M LP Sbjct: 469 NIRHDIPALTYGSYIDLDPDNNS-------VYAYTRTLGAEKYLVVINFKEEVMHYTLPG 521 Query: 654 TDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 I KV+ N + + + L+L + S ++KL Sbjct: 522 DLSINKVITENN-SHTIVNKNDRQLRLEPWQSGIYKL 557 >5DO8-B nrPDB Length = 555 Score = 119 bits (299), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 53/125 (42%), Positives = 82/125 (65%), Gaps = 1/125 (0%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVT 117 + + YQ+ SF DS+GDG GD+ G+ +KLDYL +LGV +WLSP++ +GYD+ Sbjct: 8 KKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDNGYDIR 67 Query: 118 DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYY 177 DY K+ + G + FD+L+ H+R +K+ +D V+NHT H WF E+ S ++PYR+YY Sbjct: 68 DYQKIYEEYGDMATFDQLLQGLHDRDMKLVMDLVVNHTSDEHKWFEESRKSKDNPYRDYY 127 Query: 178 SFSED 182 + E+ Sbjct: 128 FWREE 132 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 82/371 (22%), Positives = 136/371 (36%), Gaps = 85/371 (22%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAY-QAIADAAKGWIARGVDGLRLDAVKHIYHSETS 399 ++ H + DLN+ E+P Q + + K W+ +G+DG R+D + I + Sbjct: 156 YYLHLFSKKQPDLNW-------ENPKLRQDVYNMMKFWLDKGIDGFRMDVINFISKNTDF 208 Query: 400 EENPRFLKMFYEDMNAYYKQKGHTDDFY--MIGEVLSEYDKV------------APYYKG 445 + P Y D + +F M EV S+YD + A Y Sbjct: 209 PDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMNQEVTSKYDVMTVGEMPGASTTDAQIYTN 268 Query: 446 LPALFEFSFWYRLE-----------WGINNSTGCYFAKDILSYQQKYANYRSDYIEATKL 494 PA E + E W + +++ +Q + + + Sbjct: 269 -PANNEVDMIFTFEHMNLDSDSDNKWDLKPIYLPDLKENMSEWQ---VALQENGWNSLYW 324 Query: 495 SNHDEDRTSSKLGK----SADKCKLAAAVLLTSAGHPYIYYGEELGL----YGTKDN--- 543 +NHD+ R S+ G K+ A L G PYIY GEE+G+ + T D+ Sbjct: 325 NNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGTPYIYQGEEIGMTNVHFETLDDYRD 384 Query: 544 ---------------------------GDEYVRSPMLWGDSYTTNYTDKTD-ATVSKNVK 575 G + R+P W +S +T T V+ Sbjct: 385 IETLNMYKERKEQGHSHESIMQSIYTKGRDNARTPYQWDNSENAGFTTGTPWLKVNPRYT 444 Query: 576 TVADQQA--DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTK 633 + +++A + S+ Y +L +LR T + GN Y KD + I A+ Sbjct: 445 EINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGN------YRLLLPKD-EAIFAYERYT 497 Query: 634 DNEKLLVIHNF 644 +NEKL+V+ NF Sbjct: 498 ENEKLVVLCNF 508 >5X7U-A nrPDB Length = 549 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 55/121 (45%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVTDYT 120 I Y++ + F DS+ DG GD+ G+T KLDY+ LGV A+WL P + + GYD++DY Sbjct: 12 IIYEVGVRCFFDSNNDGSGDIPGLTAKLDYIESLGVTAIWLLPFYASPLKDGGYDISDYR 71 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 ++P GT DF + EAH RGI++ + V+NHT H WF EA S+ SPYR+YY +S Sbjct: 72 SLHPDFGTIEDFKVFLDEAHRRGIRVITELVLNHTSDQHQWFREARSNPNSPYRDYYVWS 131 Query: 181 E 181 + Sbjct: 132 D 132 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 75/320 (23%), Positives = 118/320 (36%), Gaps = 68/320 (21%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETS 399 Y+H F DLNY Q I D W+ GVDGLRLDAV ++Y E + Sbjct: 162 YWHRFFSHQ--PDLNYD------NPKVQQEILDIVGYWLDMGVDGLRLDAVPYLYEREGT 213 Query: 400 E-----ENPRFLKMFY--------------------EDMNAYYKQKGHTDDFYM------ 428 E FLK ED+ AY+ G+ D+ +M Sbjct: 214 NCENLPETHEFLKKLRKFVDDNWPNRMLLAEANQWPEDVVAYF---GNGDECHMAYHFPI 270 Query: 429 ---IGEVLSEYDK--VAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK--- 480 + L D+ + + P + E +W + ++++ +++ Sbjct: 271 MPRMYMALRREDRHPITEILRRTPPIPETC-----QWALFLRNHDELTLEMVTDEERDYM 325 Query: 481 YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGT 540 Y Y D +L+ R + L S + +L +L T G P IYYG+E+G+ Sbjct: 326 YHEYAKD--PRMRLNLGIRRRLAPLLDNSERRIQLMHLLLFTLPGTPIIYYGDEIGMGDN 383 Query: 541 KDNGD-EYVRSPMLWGDSYTTNYTDKT----------DATVSKNVKTVADQQADTHSLLN 589 GD + VR+PM W ++ D + V Q+ SLLN Sbjct: 384 VYLGDRDGVRTPMQWSGDRNAGFSRANPQALYLPPIRDPVFTYEAVNVEAQEQVPTSLLN 443 Query: 590 IYFSLTRLRNTYPALAEGNM 609 ++R YP G++ Sbjct: 444 WMKRTIQIRKKYPVFGRGSI 463 >3ZO9-A nrPDB Length = 593 Score = 116 bits (291), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 55/121 (45%), Positives = 78/121 (64%), Gaps = 1/121 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVTDYT 120 + Y++L+ +F DS+ DG GDL G+T+KLDY+ LGV LWL P + + GYD+ D+ Sbjct: 40 VFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLGVDCLWLPPFYDSPLRDGGYDIRDFY 99 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 KV P+ GT DF L+ AH RGI+I D VMNHT H WF E+ + + PY ++Y +S Sbjct: 100 KVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHTSDQHEWFQESRHNPDGPYGDFYVWS 159 Query: 181 E 181 + Sbjct: 160 D 160 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 85/346 (24%), Positives = 141/346 (40%), Gaps = 75/346 (21%) Query: 329 ANIMFDS-QQITYFHSHFCTDWFADLNYGPVDQAGESPAYQ-AIADAAKGWIARGVDGLR 386 +N FD ++ Y+H F DLNY ++PA Q A+ D + W+ G+DG R Sbjct: 178 SNWTFDPVRRQFYWHRFFSHQ--PDLNY-------DNPAVQEAMLDVLRFWLDLGIDGFR 228 Query: 387 LDAVKHIYHSE-TSEENPRFLKMFYEDMNAYYKQ-KGHTDDFYMIGEVLSEYDK----VA 440 LDAV +++ E T+ EN + +A+ K+ + DD Y +L+E ++ V Sbjct: 229 LDAVPYLFEREGTNCEN-------LPETHAFLKRCRKAIDDEYPGRVLLAEANQWPADVV 281 Query: 441 PYYKGLP--------ALFEFSFWYRL--------------------------EWGINNST 466 Y+ G P F F R+ +WGI Sbjct: 282 AYF-GDPDTGGDECHMAFHFPLMPRIFMAVRRESRFPISEILAQTPPIPDTAQWGIFLRN 340 Query: 467 GCYFAKDILSYQQK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTS 523 ++++ +++ YA Y D K + R + L ++ +L A+LL+ Sbjct: 341 HDELTLEMVTDEERDYMYAEYAKD--PRMKANVGIRRRLAPLLENDRNQIELFTALLLSL 398 Query: 524 AGHPYIYYGEELGLYGTKDNGD-EYVRSPMLWGDSYTTNYTDKT----------DATVSK 572 G P +YYG+E+G+ GD + VR+PM W ++ T DA Sbjct: 399 PGSPVLYYGDEIGMGDIIWLGDRDSVRTPMQWTPDRNAGFSKATPGRLYLPPNQDAVYGY 458 Query: 573 NVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNES 618 + V Q + SLLN ++ +R+ + A A G + N S Sbjct: 459 HSVNVEAQLDSSSSLLNWTRNMLAVRSRHDAFAVGTFRELGGSNPS 504 >4GI8-A nrPDB Length = 557 Score = 116 bits (290), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 51/120 (42%), Positives = 82/120 (68%), Gaps = 1/120 (0%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HGYDVT 117 ++ + YQ+ SF D++GDG GD G+T+KLDYL LG+ A+W++P + + +GYD++ Sbjct: 8 KSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDIS 67 Query: 118 DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYY 177 DY +V + GT DFDRL+ E RG+++ +D V+NH+ H WF + +S ++PYR+YY Sbjct: 68 DYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRDYY 127 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 80/207 (38%), Gaps = 50/207 (24%) Query: 494 LSNHDEDRTSSKLGKSADKCKLAAA-----VLLTSAGHPYIYYGEELGL----YGTKDNG 544 L NHD R S G + + A+A V LT G P+I+ G+ELG+ + T + Sbjct: 323 LGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFKTLQDF 382 Query: 545 D---------EYV----------------------RSPMLWGDSYTTNY-TDKTDATVSK 572 D +YV R+P W DS + T K V+ Sbjct: 383 DDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPWLKVNP 442 Query: 573 NVKTV--ADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 N + A + D S+ + Y +L +R+ PAL+ G+ N + A+ Sbjct: 443 NYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNAD-------VYAYT 495 Query: 631 MTKDNEKLLVIHNFGGTAMQLPLTDKI 657 ++D E LV+ NF L D + Sbjct: 496 RSQDGETYLVVVNFKAEPRSFTLPDGM 522 >1M53-A nrPDB Length = 570 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 51/128 (39%), Positives = 80/128 (62%), Gaps = 5/128 (3%) Query: 51 PDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS 110 P W E + YQ+ SF D++ DG GD+ G+ +KLDYL LG+ A+W++P + + Sbjct: 17 PAWWKEA----VFYQIYPRSFKDTNDDGIGDIRGIIEKLDYLKSLGIDAIWINPHYDSPN 72 Query: 111 Y-HGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS 169 +GYD+++Y ++ + GT DFD LV E R +++ +D V+NHT HPWF ++ S Sbjct: 73 TDNGYDISNYRQIMKEYGTMEDFDSLVAEMKKRNMRLMIDVVINHTSDQHPWFIQSKSDK 132 Query: 170 ESPYRNYY 177 +PYR+YY Sbjct: 133 NNPYRDYY 140 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 97/242 (40%), Gaps = 54/242 (22%) Query: 494 LSNHDEDRTSSKLGKSADKCKLAAA-----VLLTSAGHPYIYYGEELGLYG--------- 539 L NHD R S G + + A+A + LT P+IY G ELG+ Sbjct: 337 LDNHDNPRAVSHFGDDRPQWREASAKALATITLTQRATPFIYQGSELGMTNYPFRQLNEF 396 Query: 540 ----TKDNGDEYV----------------------RSPMLWGDSYTTNYTD-KTDATVSK 572 K +YV R+P W D+ +T K ++ Sbjct: 397 DDIEVKGFWQDYVQSGKVTATEFLDNVRLTSRDNSRTPFQWNDTLNAGFTRGKPWFHINP 456 Query: 573 NVKTVADQQADTH--SLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 N + ++ +T S+LN Y + +LR+ PAL G Y + +D + A+ Sbjct: 457 NYVEINAEREETREDSVLNYYKKMIQLRHHIPALVYG------AYQDLNPQD-NTVYAYT 509 Query: 631 MTKDNEKLLVIHNFGGTAMQ--LPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVF 688 T NE+ LV+ NF ++ LP D IE+V+ QQ S +L L + + V+ Sbjct: 510 RTLGNERYLVVVNFKEYPVRYTLPANDAIEEVVI--DTQQQAAAPHSTSLSLSPWQAGVY 567 Query: 689 KL 690 KL Sbjct: 568 KL 569 >5YKB-A nrPDB Length = 571 Score = 108 bits (270), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 56/133 (42%), Positives = 76/133 (57%), Gaps = 7/133 (5%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPC-MSYHGYDVT 117 ++ + Y+L + +F D +GDG GD G+T +LDYL LGV LWL P P + GYDV Sbjct: 12 KSAVFYELSVRTFQDGNGDGKGDFPGLTSRLDYLKNLGVDCLWLLPWFPSPLRDDGYDVA 71 Query: 118 DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESP----- 172 DY ++P LGT DF + EAH RG+ + D V NHT + HPWF A P Sbjct: 72 DYRGIHPDLGTLDDFKVFLREAHARGLWVIGDLVTNHTSSDHPWFQAARRGPTLPDGSPN 131 Query: 173 -YRNYYSFSEDPK 184 Y +YY +S++ K Sbjct: 132 EYHDYYVWSDEGK 144 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 93/360 (25%), Positives = 137/360 (38%), Gaps = 75/360 (20%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESP-AYQAIADAAKGWIARGVDGLRLDAVKHIYHSE- 397 Y+H F + DLNY ++P + + AA+ W+ G+DG R+DAV ++ E Sbjct: 171 YWHRFFASQ--PDLNY-------DNPKVVEELHGAARFWLDLGLDGFRVDAVPYLIEREG 221 Query: 398 TSEEN----PRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEY--DKVAPYYKGLPALFE 451 TS EN LK F ++ Y + + + E + EY + P + F Sbjct: 222 TSCENLPETHEILKGFRAMVDREYPGRLLLAEAFQWPEEVVEYFGTEAEPEFH---MCFN 278 Query: 452 FSFWYRLEWGINN-----------------STG--CYFAK--DILSYQQ--------KYA 482 F RL + S G C F + D L+ + YA Sbjct: 279 FPVMPRLYMSLKREDTSSIREIMGRLPKIPSFGQWCIFLRNHDELTLEMVTDDERAFMYA 338 Query: 483 NYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGL---YG 539 Y D K++ R + L + +L VLL G P +YYG+E+G+ G Sbjct: 339 AYAPD--ARMKINVGIRRRLAPLLDNDRRRIELLNTVLLALPGSPVLYYGDEIGMGDDLG 396 Query: 540 TKD-NGDEYVRSPMLWGDSYTTNYTDK----------TDATVSKNVKTVADQQADTHSLL 588 D NG VR+PM W + ++ D V Q D SLL Sbjct: 397 LPDRNG---VRTPMQWNAGTSGGFSTAQPSDCFFPPIQDPVYGFGRVNVQSQLQDPSSLL 453 Query: 589 NIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTA 648 LR +PA A G++T N + I A+ D E LL++ NF G A Sbjct: 454 KWTARQLELRRAHPAFAHGDLTFIETGNPA-------ILAFTRQYDGETLLIVSNFAGNA 506 >3AXH-A nrPDB Length = 589 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 56/148 (37%), Positives = 83/148 (56%), Gaps = 2/148 (1%) Query: 45 TALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSP 104 T +A P+T + + YQ+ SF DS+ DG+GD+ G+ KL+Y+ +LG A+W+SP Sbjct: 2 TISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISP 61 Query: 105 IHPC-MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFT 163 + GYD+ +Y KV P GT D L+ + H G+K D V+NH + H WF Sbjct: 62 FYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFK 121 Query: 164 EASSSSESPYRNYYSFSEDPKTDIAAGK 191 E+ SS +P R+++ F PK A GK Sbjct: 122 ESRSSKTNPKRDWF-FWRPPKGYDAEGK 148 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 57/252 (22%), Positives = 101/252 (40%), Gaps = 58/252 (23%) Query: 333 FDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG-WIARGVDGLRLDA-- 389 FD + ++ FC+ DLN+ D +AI ++A G W+ GVDG R+D Sbjct: 166 FDEKTQEFYLRLFCSTQ-PDLNWENED------CRKAIYESAVGYWLDHGVDGFRIDVGS 218 Query: 390 ----VKHIYHSETSEEN-------------PRFLKMFYEDMNAYYKQK-GHTDDFYMIGE 431 V + + ++N PR + F+++MN + + + + +G Sbjct: 219 LYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPR-IHEFHQEMNQFIRNRVKDGREIMTVGA 277 Query: 432 VLSEYDKVAPYYKG-----LPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK------ 480 + D+ Y L LF FS + T F +++ ++ K Sbjct: 278 MQHASDETKRLYTSASRHELSELFNFSH-------TDVGTSPLFRYNLVPFELKDWKIAL 330 Query: 481 -----YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTS-----AGHPYIY 530 Y N +D L NHD+ R+ ++ G + K ++ + LL+ G Y+Y Sbjct: 331 AELFRYIN-GTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVY 389 Query: 531 YGEELGLYGTKD 542 G+ELG K+ Sbjct: 390 QGQELGQINFKN 401 >1LWJ-A nrPDB Length = 441 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 47/126 (37%), Positives = 76/126 (60%), Gaps = 2/126 (1%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTK 121 I YQ+ + SF D + DG GD G+ + YL +LG+ +WL P+ +S+HGYDV D+ Sbjct: 2 IGYQIYVRSFRDGNLDGVGDFRGLKNAVSYLKELGIDFVWLMPVFSSISFHGYDVVDFYS 61 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSE 181 + G+E +F ++ H+ GIK+ LD ++HTG H WF +A + YR+YY ++ Sbjct: 62 FKAEYGSEREFKEMIEAFHDSGIKVVLDLPIHHTGFLHTWFQKA-LKGDPHYRDYYVWA- 119 Query: 182 DPKTDI 187 + +TD+ Sbjct: 120 NKETDL 125 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 51/179 (28%), Positives = 81/179 (45%), Gaps = 20/179 (11%) Query: 381 GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVA 440 GVDG R DA KH+ +T E+N RF K F D+ + + E+ +E V Sbjct: 179 GVDGFRFDAAKHM--RDTIEQNVRFWKYFLSDLKGIF-----------LAEIWAEARMVD 225 Query: 441 PYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED 500 + + + F + ++ + + I + A DY+ SNHD Sbjct: 226 EHGRIFGYMLNFDTSHCIKEAVWKENTRVLIESI-----ERAVIAKDYLPVNFTSNHDMS 280 Query: 501 RTSS-KLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGT-KDNGDEYVRSPMLWGDS 557 R +S + G S +K KL+ ++L T G P ++YG+ELG+ G + E V P W +S Sbjct: 281 RLASFEGGFSKEKIKLSISILFTLPGVPLVFYGDELGMKGVYQKPNTEVVLDPFPWNES 339 >5BN7-A nrPDB Length = 616 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 47/110 (42%), Positives = 67/110 (60%), Gaps = 7/110 (6%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL+G+++KL YL +LGV AL+L+P+ S H YD DY V+PQ G + RL Sbjct: 179 GDLDGISEKLPYLKKLGVTALYLNPVFKAPSVHKYDTEDYRHVDPQFGGDGALLRLRHNT 238 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTE-------ASSSSESPYRNYYSFSED 182 G+++ LD V NH+G +H WF A + ESP+R++YSFS+D Sbjct: 239 QQLGMRLVLDGVFNHSGDSHAWFDRHNRGTGGACHNPESPWRDWYSFSDD 288 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 75/190 (39%), Gaps = 35/190 (18%) Query: 382 VDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE--------VL 433 +DG RLD V + + + N + + E K + Y++GE + Sbjct: 332 MDGWRLDVVHMLGEAGGARNNMQHVAGITE------AAKETQPEAYIVGEHFGDARQWLQ 385 Query: 434 SEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYA---NYRSDYIE 490 ++ + A Y+G F F W G +T + + Q A NYR+ Sbjct: 386 ADVEDAAMNYRG----FTFPLW-----GFLANTDISYDPQQIDAQTCMAWMDNYRAGLSH 436 Query: 491 ATKLS------NHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNG 544 +L +HD R + LG+ + LA L T G P IYYG+E+GL G Sbjct: 437 QQQLRMFNQLDSHDTARFKTLLGRDIARLPLAVVWLFTWPGVPCIYYGDEVGLDG---KN 493 Query: 545 DEYVRSPMLW 554 D + R P W Sbjct: 494 DPFCRKPFPW 503 >5A2B-A nrPDB Length = 497 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 43/91 (47%), Positives = 58/91 (63%), Gaps = 2/91 (2%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVT 137 GDL G+ KLDY+ ++G A+WL+PI + YHGY + D+ KV GT DF RLV Sbjct: 75 GDLQGIIDKLDYIKEMGFTAIWLTPIFANEKGGYHGYWIEDFYKVEEHFGTLDDFKRLVK 134 Query: 138 EAHNRGIKIYLDYVMNHTGTAHPWFTEASSS 168 EAH R +K+ LD+V+NHTG HPW + + Sbjct: 135 EAHKRDMKVILDFVVNHTGYNHPWLNDPAKK 165 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/196 (30%), Positives = 91/196 (46%), Gaps = 23/196 (11%) Query: 355 YGPVDQAGESPAYQA-IADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 +G D A E+P + + D AK WI +DG RLD VKH+ K F+++ Sbjct: 189 FGLPDLAQENPEVKTYLFDVAKWWIQETDIDGYRLDTVKHV------------PKWFWDE 236 Query: 413 MNAYYKQKGHTDDFYMIGEVLSEYDK-VAPYYK-GLPALFEFSFWYRLEWGINNSTGCYF 470 + K DF+++GEV + + VA Y K G+ AL +F F Y+ I ++ Sbjct: 237 FAK--EVKSVKQDFFLLGEVWHDDPRYVAEYGKHGIDALIDFPF-YKEASTIFSNVDQSL 293 Query: 471 AKDILSYQQKYANYRSDYIEATKLSNHDEDR-TSSKLGKSAD---KCKLAAAVLLTSAGH 526 +++ A Y Y+ T L NHD R T L + + KL L ++ G Sbjct: 294 EPLYNVWKRNVAFYERPYLLGTFLDNHDTVRFTRLALQNRINPVTRLKLGLTYLFSAPGI 353 Query: 527 PYIYYGEELGLYGTKD 542 P +YYG E+ L G +D Sbjct: 354 PIMYYGTEIALDGGED 369 >4E2O-A nrPDB Length = 454 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 46/99 (46%), Positives = 61/99 (61%), Gaps = 4/99 (4%) Query: 74 SDGDGY--GDLNGVTQKLDYLNQLGVKALWLSPIHPCM--SYHGYDVTDYTKVNPQLGTE 129 +D GY GDL GVT KLDY+ ++G A+WL+PI M YHGY + D+ +V+P GT Sbjct: 34 NDPKGYFGGDLKGVTAKLDYIKEMGFTAIWLTPIFKNMPGGYHGYWIEDFYQVDPHFGTL 93 Query: 130 SDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSS 168 D LV EAH R +K+ LD+V NH G HPW + + Sbjct: 94 GDLKTLVKEAHKRDMKVILDFVANHVGYNHPWLHDPTKK 132 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 91/197 (46%), Gaps = 25/197 (12%) Query: 355 YGPVDQAGESPAYQA-IADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 YG D A E+P + + DAAK WI +DG RLD V+H+ S F + F ++ Sbjct: 156 YGLPDLAQENPEVKTYLIDAAKWWIKETDIDGYRLDTVRHVPKS--------FWQEFAKE 207 Query: 413 MNAYYKQKGHTDDFYMIGEVLSEYDK-VAPYYK-GLPALFEFSFWYRLEWGINNSTGCYF 470 + + K DF+++GEV S+ + +A Y K G+ ++ + ++ + Sbjct: 208 VKSVKK------DFFLLGEVWSDDPRYIADYGKYGIDGFVDYPLYGAVKQSLARRDASLR 261 Query: 471 AK-DILSYQQKYANYRSDYIEATKLSNHDEDRTSS----KLGKSADKCKLAAAVLLTSAG 525 D+ Y + + Y Y+ + L NHD R + + KLA L T+ G Sbjct: 262 PLYDVWEYNKTF--YDRPYLLGSFLDNHDTVRFTKLAIDNRNNPISRIKLAMTYLFTAPG 319 Query: 526 HPYIYYGEELGLYGTKD 542 P +YYG E+ + G +D Sbjct: 320 IPIMYYGTEIAMNGGQD 336 >5OT1-A nrPDB Length = 765 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 42/105 (40%), Positives = 66/105 (62%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GD+ G+T+KLDYL LGV ++++PI S HGYD DY +++P+ GTE + + EA Sbjct: 349 GDIKGITEKLDYLQSLGVTIIYINPIFLSGSAHGYDTYDYYRLDPKFGTEDELREFLDEA 408 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFSEDP 183 H RG+++ D+V NH G +P F + +ESPY +++ + P Sbjct: 409 HRRGMRVIFDFVPNHCGIGNPAFLDVWEKGNESPYWDWFFVKKWP 453 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 68/298 (22%), Positives = 114/298 (38%), Gaps = 66/298 (22%) Query: 370 IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 + AA WI G DG+R+D + T F+ ++ K+K D Y++ Sbjct: 485 LIGAALHWIEFGFDGIRVDVPNEVLDPGT----------FFPELRKAVKEK--KPDAYLV 532 Query: 430 GEVLS---------EYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK 480 GE+ + +D + Y G L ++ G Y+A SY + Sbjct: 533 GEIWTLSPEWVKGDRFDSLMNYALGRDILLNYAKGLLSGESAMKMMGRYYA----SYGEN 588 Query: 481 YANYRSDYIEATKLSNHDEDRTSSKLG-----KSADKCKLAAAVLLTSAGHPYIYYGEEL 535 + +++ S D KLG +S + KL + +L G P + G+E Sbjct: 589 VVAMGFNLVDSHDTSRVLTDLGGGKLGDTPSNESIQRLKLLSTLLYALPGTPVTFQGDER 648 Query: 536 GLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLT 595 GL G K + DE R P+ W TV+++V LN Y +L Sbjct: 649 GLLGDKGHYDEQ-RYPIQW-------------DTVNEDV-------------LNHYRALA 681 Query: 596 RLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTA-MQLP 652 LR PAL M ++ + A++ +E L+V +++ A ++LP Sbjct: 682 ELRKRVPALRSSAMRFYTAKGG--------VMAFFRGHHDEVLVVANSWKKPALLELP 731 >4AEE-A nrPDB Length = 696 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 48/120 (40%), Positives = 67/120 (55%), Gaps = 1/120 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL G+ + +D+L LGV+ ++L+PI SYH YD DY ++ LGT DF++LV Sbjct: 262 GDLAGIMKHIDHLEDLGVETIYLTPIFSSTSYHRYDTIDYKSIDKYLGTMEDFEKLVQVL 321 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDPKTDIAAGKIAMITQE 198 H+R IKI LD M+HT + F +A E SPY +SF P +I + I E Sbjct: 322 HSRKIKIVLDITMHHTNPCNELFVKALREGENSPYWEMFSFLSPPPKEIVELMLKYIDGE 381 Score = 55.5 bits (132), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 34/191 (17%) Query: 371 ADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIG 430 D K WI +G+DG R+D I++S ++K +YE + Y DF ++G Sbjct: 425 IDITKFWIDKGIDGFRIDVAMGIHYS--------WMKQYYEYIKNTYP------DFLVLG 470 Query: 431 EV-------LSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYAN 483 E+ + +D YY A+ E + R++ +N F I + + Sbjct: 471 ELAENPRIYMDYFDSAMNYYLR-KAILELLIYKRID--LNE-----FISRINNVYAYIPH 522 Query: 484 YRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN 543 Y++ + L +HD R S + ++ KL ++ G P IYYG+E+GL G +D Sbjct: 523 YKALSL-YNMLGSHDVPRIKS-MVQNNKLLKLMYVLIFALPGSPVIYYGDEIGLEGGRDP 580 Query: 544 GDEYVRSPMLW 554 + R PM+W Sbjct: 581 DN---RRPMIW 588 >1JL8-A nrPDB Length = 585 Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 49/104 (47%), Positives = 61/104 (58%), Gaps = 2/104 (1%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL GV +L YL +LGV AL+ +PI S+H YD DY ++PQ G F RLV EA Sbjct: 170 GDLKGVIDRLPYLEELGVTALYFTPIFASPSHHKYDTADYLAIDPQFGDLPTFRRLVDEA 229 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSED 182 H RGIKI LD V NH G F + E S Y++++ F ED Sbjct: 230 HRRGIKIILDAVFNHAGDQFFAFRDVLQKGEQSRYKDWF-FIED 272 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 58/249 (23%), Positives = 94/249 (37%), Gaps = 59/249 (23%) Query: 370 IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 + D A+ W+ +G+DG RL+ + H+ E R +K D + H +++ Sbjct: 307 LFDVARFWMEQGIDGWRLNVANEVDHA-FWREFRRLVKSLNPDA-LIVGEIWHDASGWLM 364 Query: 430 GEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDIL---SYQQKYANYRS 486 G+ ++D V Y LF S +FA + + + R Sbjct: 365 GD---QFDSVMNY------LF------------RESVIRFFATGEIHAERFDAELTRARM 403 Query: 487 DYIEATK------LSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGT 540 Y E L +HD +R + G + K +LA +T G P IYYG+E+G+ G Sbjct: 404 LYPEQAAQGLWNLLDSHDTERFLTSCGGNEAKFRLAVLFQMTYLGTPLIYYGDEIGMAGA 463 Query: 541 KDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNT 600 D R PM+W +++ L Y L RLR+ Sbjct: 464 TDPD---CRRPMIW------------------------EEKEQNRGLFEFYKELIRLRHR 496 Query: 601 YPALAEGNM 609 +L GN+ Sbjct: 497 LASLTRGNV 505 >4AEF-A nrPDB Length = 645 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 54/155 (34%), Positives = 83/155 (53%), Gaps = 16/155 (10%) Query: 42 GQWTALTASPD--TWDETKRADISYQLLLYSFADS---DGDGY-------GDLNGVTQKL 89 GQ+ A S + TW + + YQ++ FA S G Y GDL G+ +K+ Sbjct: 189 GQFKARPFSIEFPTWVIDR---VFYQIMPDKFARSRKIQGIAYPKDKYWGGDLIGIKEKI 245 Query: 90 DYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLD 149 D+L LG+ A++L+PI ++YHGYD+ DY V +LG + F L++E IK+ LD Sbjct: 246 DHLVNLGINAIYLTPIFSSLTYHGYDIVDYFHVARRLGGDRAFVDLLSELKRFDIKVILD 305 Query: 150 YVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDP 183 V +HT HP+F + E S ++N+Y + P Sbjct: 306 GVFHHTSFFHPYFQDVVRKGENSSFKNFYRIIKFP 340 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 113/268 (42%), Gaps = 49/268 (18%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFY 427 + I + W +GVDG R+D H E ++ E A K+K Y Sbjct: 391 EFIKNVILFWTNKGVDGFRMDVA----HGVPPE-------VWKEVREALPKEK------Y 433 Query: 428 MIGEVLSE-----YDKV--APYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK 480 +IGEV+ + +DK Y+ A+ F +G T F ++ Sbjct: 434 LIGEVMDDARLWLFDKFHGVMNYRLYDAILRF-------FGYEEITAEEFLNELELLSSY 486 Query: 481 YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAV--LLTSAGHPYIYYGEELGLY 538 Y ++Y+ L NHD +R +G DK K A+ L+T G P ++YG+E+GL Sbjct: 487 YGP--AEYLMYNFLDNHDVERFLDIVG---DKRKYVCALVFLMTYKGIPSLFYGDEIGLR 541 Query: 539 GTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLR 598 G G E R+PMLW + ++ D + + KT+ + + +LL F + + Sbjct: 542 GINLQGMESSRAPMLWNE-------EEWDQRILEITKTLVKIRKNNKALLFGNFVPVKFK 594 Query: 599 NTYPALAEGNMTKHSV----YNESQEKD 622 + +M + ++ Y+ S+ K+ Sbjct: 595 RKFMVYKREHMGERTIVAINYSNSRVKE 622 >1EA9-C nrPDB Length = 583 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 39/105 (37%), Positives = 61/105 (58%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL GV LD+L++LGV A++ +P+ + H YD DY +++PQ G + +LV Sbjct: 169 GDLQGVIDHLDHLSKLGVNAVYFTPLFKATTNHKYDTEDYFQIDPQFGDKDTLKKLVDLC 228 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDP 183 H RGI++ LD V NH+G P F + + E S Y++++ P Sbjct: 229 HERGIRVLLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLP 273 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 70/298 (23%), Positives = 109/298 (36%), Gaps = 72/298 (24%) Query: 370 IADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYM 428 + AA+ WI G+DG RLD + H F+ + KQ D Y+ Sbjct: 306 LLKAAEYWIRETGIDGWRLDVANEVSHQ------------FWREFRRVVKQAN--PDAYI 351 Query: 429 IGEVLSEYDKVAPYYKG--LPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQ------- 479 +GEV E + + +G A+ + F N+ +F I ++ Sbjct: 352 LGEVWHE---SSIWLEGDQFDAVMNYPF--------TNAVLDFFIHQIADAEKFSFMLGK 400 Query: 480 KYANY--RSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGL 537 + A Y ++ + L +HD R ++ K KLA T G P IYYG+E+GL Sbjct: 401 QLAGYPRQASEVMFNLLDSHDTARLLTQADGDKRKMKLAVLFQFTYFGTPCIYYGDEVGL 460 Query: 538 YGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRL 597 G D G R M W D+ L Y ++ RL Sbjct: 461 DGGHDPG---CRKCMEW------------------------DETKHDKDLFAFYQTVIRL 493 Query: 598 RNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN--FGGTAMQLPL 653 R + AL G + S++ A+ D + +LV+ N G + LP+ Sbjct: 494 RQAHAALRTGTFKFLTAEKNSRQ------IAYLREDDQDTILVVMNNDKAGHTLTLPV 545 >6A0L-A nrPDB Length = 471 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 42/107 (39%), Positives = 60/107 (56%), Gaps = 1/107 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL G+ LD++ LG AL+L+PI + H YD DY ++ +LGT F L+ E Sbjct: 68 GDLQGIIDHLDHIVALGANALYLTPIFEADTNHRYDAKDYFSIDHRLGTLETFHALMAEC 127 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTE-ASSSSESPYRNYYSFSEDPKT 185 RGI+I LD V+NH G H F + + ++S Y N++S P T Sbjct: 128 RARGIRIVLDAVLNHCGDGHWAFADVVENEADSAYVNWFSVEGFPVT 174 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 24/197 (12%) Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 D A+ WI +G+DG RLD I H+ F + F + KG ++D Y++ E Sbjct: 206 DVARYWIDQGIDGWRLDVPYFINHT--------FWREFRTAV------KGKSEDLYIVAE 251 Query: 432 VLSEYDKVAPYYKGLPALFEFSFWYR-LEWGINNSTGCYFAKDILSYQQKYANYRSDYIE 490 E+ + +G A ++ R L G G + +A + + Sbjct: 252 ---EWRSPVEWLQGDTADGTMNYTARDLILGFTADGGIDASALAAGLNALHAEIPAGFHR 308 Query: 491 A--TKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYV 548 L +HD +R ++ + L+ A+L + G P +YYG+E+GL G D G Sbjct: 309 GMLNLLGSHDTERVLTRHAGDVEAALLSYALLFSLEGAPMVYYGDEVGLTGDNDPG---C 365 Query: 549 RSPMLWG-DSYTTNYTD 564 R M W +S+ T D Sbjct: 366 RGAMPWNEESWNTRLLD 382 >5Z0U-A nrPDB Length = 626 Score = 79.3 bits (194), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 59/182 (32%), Positives = 82/182 (45%), Gaps = 31/182 (17%) Query: 54 WDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQ-LGVKALWLSPIHPCMSYH 112 W + AD Y L F GDL G+ QKL Y+ + LG L+L+PI + H Sbjct: 169 WGSSVYADPGYDNSLVFFG-------GDLAGIDQKLGYIKKTLGANILYLNPIFKAPTNH 221 Query: 113 GYDVTDYTKVNPQLGTESDFDRLVTEAHN--RGIKIY--LDYVMNHTGTAHPWFTE---- 164 YD DY V+P G S L+ + H+ G K Y LD V NHTG +HPWF + Sbjct: 222 KYDTQDYMAVDPAFGDNSTLQTLINDIHSTANGPKGYLILDGVFNHTGDSHPWFDKYNNF 281 Query: 165 ----ASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDETAAVKG 220 A S SP+ NYY+F P + G+N+ + +AV+G Sbjct: 282 SSQGAYESQSSPWYNYYTFYTWPD-----------SYASFLGFNSLPKLNYGNSGSAVRG 330 Query: 221 LL 222 ++ Sbjct: 331 VI 332 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 100/273 (36%), Gaps = 62/273 (22%) Query: 353 LNYGPVDQAGESPAYQAIADAAKGWI--ARGVDGLRLDAVKHIYHSETSE---------E 401 LNYG A Y AK ++ VDG RLDA +++ H SE Sbjct: 319 LNYGNSGSAVRGVIYNNSNSVAKTYLNPPYSVDGWRLDAAQYVDHQIWSEFRNAVKGVNS 378 Query: 402 NPRFLKMFYEDMNAYYKQKGHTD---DFYMIGEVLSEYDKVAPYYKGLPAL--FEFSFWY 456 N + ++ + N + Q D +F + +SE+ Y ++ +F W Sbjct: 379 NAAIIGEYWGNANPWTAQGNQWDAATNFDGFTQPVSEWITGKDYQNNSASISTTQFDSWL 438 Query: 457 RLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLA 516 R T + ++ QQ N+ LSNHD R +++ G K LA Sbjct: 439 R-------GTRANYPTNV---QQSMMNF---------LSNHDITRFATRSGGDLWKTYLA 479 Query: 517 AAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKT 576 +T G P IYYG+E G+ G D + R W Sbjct: 480 LIFQMTYVGTPTIYYGDEYGMQGGADPDN---RRSFDW---------------------- 514 Query: 577 VADQQADTHSLLNIYFSLTRLRNTYPALAEGNM 609 Q ++S + + L +RN YPAL G+ Sbjct: 515 --SQATPSNSAVALTQKLITIRNQYPALRTGSF 545 >1SMA-A nrPDB Length = 588 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL G+ LDYL LG+ ++L+PI S H YD DY +++P G + LV Sbjct: 173 GDLQGIIDHLDYLADLGITGIYLTPIFRAPSNHKYDTADYFEIDPHFGDKETLKTLVKRC 232 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFSEDP 183 H +GI++ LD V NH G F + + + S Y++++ E P Sbjct: 233 HEKGIRVMLDAVFNHCGYEFAPFQDVLKNGAASRYKDWFHIREFP 277 Score = 60.1 bits (144), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 80/355 (22%), Positives = 135/355 (38%), Gaps = 68/355 (19%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFL 406 D FA + + P + + D A WI +DG RLD I H +F Sbjct: 287 DTFAFVPHMPKLNTAHPEVKRYLLDVATYWIREFDIDGWRLDVANEIDH--------QFW 338 Query: 407 KMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNST 466 + F + + A D Y++GE+ ++ +P L F + + + ++ Sbjct: 339 REFRQAVKAL------KPDVYILGEI---------WHDAMPWLRGDQFDAVMNYPLADAA 383 Query: 467 GCYFAKDILS---YQQKYANYRSDYIEATK------LSNHDEDRTSSKLGKSADKCKLAA 517 +FAK+ +S + + + Y + L +HD R + G K KL Sbjct: 384 LRFFAKEDMSASEFADRLMHVLHSYPKQVNEAAFNLLGSHDTPRLLTVCGGDVRKVKLLF 443 Query: 518 AVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTV 577 LT G P IYYG+E+G+ G D R M+W +K + + ++VK Sbjct: 444 LFQLTFTGSPCIYYGDEIGMTG---GNDPECRKCMVWD-------PEKQNKELYEHVK-- 491 Query: 578 ADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEK 637 L LR Y AL G++ + +E Y T NE Sbjct: 492 ---------------QLIALRKQYRALRRGDVAFLTADDEVNHLVYA------KTDGNET 530 Query: 638 LLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTL--KLGGYASVVFKL 690 +++I N A ++P+ VN T + +++ TL L Y V++ + Sbjct: 531 VMIIINRSNEAAEIPMPIDARGKWLVNLLTGERFAAEAETLCVSLPPYGFVLYAV 585 >1J0H-A nrPDB Length = 588 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 38/105 (36%), Positives = 56/105 (53%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL G+ LDYL LG+ ++L+PI S H YD DY +V+P G + L+ Sbjct: 173 GDLQGIIDHLDYLVDLGITGIYLTPIFRSPSNHKYDTADYFEVDPHFGDKETLKTLIDRC 232 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDP 183 H +GI++ LD V NH G F + + E S Y++++ E P Sbjct: 233 HEKGIRVMLDAVFNHCGYEFAPFQDVWKNGESSKYKDWFHIHEFP 277 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 84/356 (23%), Positives = 134/356 (37%), Gaps = 70/356 (19%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFL 406 D FA + P + + D A WI +DG RLD I H F Sbjct: 287 DTFAFVPQMPKLNTANPEVKRYLLDVATYWIREFDIDGWRLDVANEIDHE--------FW 338 Query: 407 KMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNST 466 + F +++ A D Y++GE+ ++ +P L F + + + Sbjct: 339 REFRQEVKAL------KPDVYILGEI---------WHDAMPWLRGDQFDAVMNYPFTDGV 383 Query: 467 GCYFAKDILSYQQKYAN--------YRSDYIEAT--KLSNHDEDRTSSKLGKSADKCKLA 516 +FAK+ +S +Q +AN Y ++ EA L +HD R + G K KL Sbjct: 384 LRFFAKEEISARQ-FANQMMHVLHSYPNNVNEAAFNLLGSHDTSRILTVCGGDIRKVKLL 442 Query: 517 AAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKT 576 LT G P IYYG+E+G+ G D R M+W + + + ++VK Sbjct: 443 FLFQLTFTGSPCIYYGDEIGMTG---GNDPECRKCMVWDPM-------QQNKELHQHVK- 491 Query: 577 VADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNE 636 L LR Y +L G ++ +E YK T +E Sbjct: 492 ----------------QLIALRKQYRSLRRGEISFLHADDEMNYLIYK------KTDGDE 529 Query: 637 KLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTL--KLGGYASVVFKL 690 +LVI N +P+ VN T + +++ TL L Y V++ + Sbjct: 530 TVLVIINRSDQKADIPIPLDARGTWLVNLLTGERFAAEAETLCTSLPPYGFVLYAI 585 >1QHO-A nrPDB Length = 686 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 43/127 (33%), Positives = 60/127 (47%), Gaps = 30/127 (23%) Query: 59 RADISYQLLLYSFADSDGDGY---------------------GDLNGVTQKLDYLNQLGV 97 + D+ YQ+++ F D D GDL GV QKL YL QLGV Sbjct: 7 KGDVIYQIIIDRFYDGDTTNNNPAKSYGLYDPTKSKWKMYWGGDLEGVRQKLPYLKQLGV 66 Query: 98 KALWLSPIHPCM---------SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL 148 +WLSP+ + YHGY D+ ++ G + FD LV +AH GIK+ + Sbjct: 67 TTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQIEEHFGNWTTFDTLVNDAHQNGIKVIV 126 Query: 149 DYVMNHT 155 D+V NH+ Sbjct: 127 DFVPNHS 133 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 85/328 (25%), Positives = 129/328 (39%), Gaps = 64/328 (19%) Query: 368 QAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFY 427 Q + DAA +A G DGLR+DAVKH N F K + + Y++K D + Sbjct: 208 QYLTDAAVQLVAHGADGLRIDAVKHF--------NSGFSKSLADKL---YQKK----DIF 252 Query: 428 MIGEVLSEYDKVAPYYK--------GLPAL-FEFSFWYRLEWGINNSTGCYFAKDILSYQ 478 ++GE + A + + G+ L F+ + R +G T Y ++++ Sbjct: 253 LVGEWYGDDPGTANHLEKVRYANNSGVNVLDFDLNTVIRNVFGTFTQT-MYDLNNMVNQT 311 Query: 479 QKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKL--AAAVLLTSAGHPYIYYGEELG 536 Y+ + I T + NHD R L +++K L A A +LTS G P IYYG E Sbjct: 312 GNEYKYKENLI--TFIDNHDMSRF---LSVNSNKANLHQALAFILTSRGTPSIYYGTEQY 366 Query: 537 LYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTR 596 + G D Y R M D+ TT + K V T+A Sbjct: 367 MAGGN---DPYNRGMMPAFDTTTTAF---------KEVSTLAG----------------- 397 Query: 597 LRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLP---L 653 LR A+ G T+ + N+ + K + N ++ G LP Sbjct: 398 LRRNNAAIQYGTTTQRWINNDVYIYERKFFNDVVLVAINRNTQSSYSISGLQTALPNGSY 457 Query: 654 TDKIEKVLFVNGETQQNTDSDSYTLKLG 681 D + +L NG + N S+TL G Sbjct: 458 ADYLSGLLGGNGISVSNGSVASFTLAPG 485 >2Z1K-A nrPDB Length = 475 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 41/105 (39%), Positives = 57/105 (54%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 G L GV +KL YL LGV+A++L+P+ + H Y DY +V+P LG L+ A Sbjct: 47 GTLWGVAEKLPYLLDLGVEAIYLNPVFASTANHRYHTVDYFQVDPILGGNEALRHLLEVA 106 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDP 183 H G+++ LD V NHTG F + E SPYR++Y P Sbjct: 107 HAHGVRVILDGVFNHTGRGFFAFQHLMENGEQSPYRDWYHVKGFP 151 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 111/260 (42%), Gaps = 59/260 (22%) Query: 363 ESPAYQA-IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKG 421 E+PA + + A+ WI GVDG RLD I +P F + F + + KG Sbjct: 176 ETPAVREYLLAVAEHWIRFGVDGWRLDVPNEI-------PDPTFWREFRQ------RVKG 222 Query: 422 HTDDFYMIGEVLSE---------YDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAK 472 + Y++GE+ E +D V Y A+ F L+ + TG + Sbjct: 223 ANPEAYIVGEIWEEADFWLQGDMFDAVMNYPLAR-AVLGFVGGEALDRDLAAQTGLGRIE 281 Query: 473 DI--LSYQQK----YANYRSDYIEATK--LSNHDEDRTSSKLGKSADKCKLAAAVLLTSA 524 + L++ + + YR + + A L++HD R S + S ++ +LA A+L Sbjct: 282 PLQALAFSHRLEDLFGRYRPEVVRAQMNLLTSHDTPRLLSLMRGSVERARLALALLFLLP 341 Query: 525 GHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADT 584 G+P +YYGEE+G+ G KD + R M+W +A K+++ + Sbjct: 342 GNPTVYYGEEVGMAGGKDPEN---RGGMVW-----------EEARWQKDLRETVKR---- 383 Query: 585 HSLLNIYFSLTRLRNTYPAL 604 L RLR +PAL Sbjct: 384 ---------LARLRKEHPAL 394 >2WC7-A nrPDB Length = 488 Score = 75.5 bits (184), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 38/105 (36%), Positives = 56/105 (53%), Gaps = 1/105 (0%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEA 139 GDL G+ + LDY+ LG+ A++ +PI S H Y DY +V+P LG F L+ A Sbjct: 53 GDLWGIMEDLDYIQNLGINAIYFTPIFQSASNHRYHTHDYYQVDPMLGGNEAFKELLDAA 112 Query: 140 HNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFSEDP 183 H R IK+ LD V NH+ +F + + SP+ N++ P Sbjct: 113 HQRNIKVVLDGVFNHSSRGFFFFHDVLENGPHSPWVNWFKIEGWP 157 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 76/332 (22%), Positives = 129/332 (38%), Gaps = 70/332 (21%) Query: 370 IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 I + A+ W+ G+DG RLD I + P F + F + + K + Y++ Sbjct: 192 IMEIAEYWLKFGIDGWRLDVPFEI-------KTPGFWQEFRD------RTKAINPEAYIV 238 Query: 430 GEVL---------SEYDKVAPYYKGLPAL-FEFSFWYRLEWGINNSTGCY---FAKDILS 476 GEV +++D V Y P + F LE + Y FA + + Sbjct: 239 GEVWGDSRQWLDGTQFDGVMNYLFAGPTIAFAAGDRVVLEQVQSRDYQPYPPLFAAEYAT 298 Query: 477 YQQKYANYRSDYIEATKL---SNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGE 533 Q+ I+ T+L ++HD R + G +L+ +LLT G P IYYG+ Sbjct: 299 KIQEVLQLYPWEIQLTQLNLLASHDTARLMTIAGGDIASVELSTLLLLTFPGAPSIYYGD 358 Query: 534 ELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFS 593 E+GL G D D+ ++ +Q+ + N + Sbjct: 359 EVGLPGGID-----------------------PDSRRGFPLEANWNQE-----IFNTHRQ 390 Query: 594 LTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQ--- 650 L +R TYPAL G+ +Y + Q + + T E+L++ N G ++ Sbjct: 391 LITIRQTYPALRTGDY--QVLYAQGQ------LYLFARTLGTEELIIAINAGTSSATANV 442 Query: 651 --LPLTDKIEKVLFVNGETQQNTDSDSYTLKL 680 L + K+L+ E + N + + L L Sbjct: 443 DVASLHTQPNKLLYGTAEAEWNGEEGTQQLSL 474 >3HJE-A nrPDB Length = 704 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/168 (33%), Positives = 78/168 (46%), Gaps = 20/168 (11%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCM--SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNR 142 + +LDY +LGV L+LSP+ S HGYDV DY +N +LG E ++ RL+ EA ++ Sbjct: 17 IRNRLDYFVELGVTHLYLSPVLKARPGSTHGYDVVDYNTINDELGGEEEYIRLIDEAKSK 76 Query: 143 GIKIYLDYVMNHTGTAHP-W--FTEASSSSESPYRNYYSF-SEDPKTDIAA-----GKIA 193 G+ I D V NH H W S Y NY+ F E+ K I KI Sbjct: 77 GLGIIQDIVPNHMAVHHTNWRLMDVLKKGRHSRYYNYFDFYEEEEKIRIPILGDRNFKIT 136 Query: 194 MITQEGAAGYNAAEWFQVSDETAA----VKGLLKFT----LDWSNAPS 233 + E Y F ++DE ++ LLK +DW + PS Sbjct: 137 YVNDEPYLDY-YGNLFPINDEGRNYLNDIEKLLKVQYYELVDWRDYPS 183 >3UER-A nrPDB Length = 655 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 42/108 (38%), Positives = 54/108 (50%), Gaps = 4/108 (3%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPI-HPCMSYH--GYDVTDYTKVNPQLGTESDFDRLV 136 G L GV ++LDYL LGVK L L P+ P + GY V DY V P LGT D L Sbjct: 108 GTLKGVEERLDYLEGLGVKYLHLMPLLRPREGENDGGYAVQDYRAVRPDLGTMDDLSALA 167 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPK 184 RGI + LD V+NH H W + + + + YR Y+ D + Sbjct: 168 RALRGRGISLVLDLVLNHVAREHAW-AQKARAGDPKYRAYFHLFPDRR 214 >5ZCR-A nrPDB Length = 728 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 42/105 (40%), Positives = 57/105 (54%), Gaps = 5/105 (4%) Query: 86 TQKLDYLNQLGVKALWLSPIHPCM--SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG 143 + LDY +LGV L+LSPI S HGYDV D++++N +LG E + +LV EA +RG Sbjct: 20 IENLDYFKELGVSHLYLSPILKARPGSTHGYDVVDHSEINEELGGEEGYFKLVKEAKSRG 79 Query: 144 IKIYLDYVMNHTGTAHP-W--FTEASSSSESPYRNYYSFSEDPKT 185 ++I D V NH H W S S Y NY+ +D K Sbjct: 80 LEIIQDIVPNHMAVHHTNWRLMDLLKSWKNSKYYNYFDHYDDDKI 124 >1CYG-A nrPDB Length = 680 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 39/92 (42%), Positives = 51/92 (55%), Gaps = 13/92 (14%) Query: 80 GDLNGVTQKLD--YLNQLGVKALWLS-PIHPCMS----------YHGYDVTDYTKVNPQL 126 GD G+ K++ YL +GV A+W+S P+ S YHGY D+ K NP Sbjct: 49 GDWQGIINKINDGYLTDMGVTAIWISQPVENVFSVMNDASGSASYHGYWARDFKKPNPFF 108 Query: 127 GTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 GT SDF RLV AH +GIK+ +D+ NHT A Sbjct: 109 GTLSDFQRLVDAAHAKGIKVIIDFAPNHTSPA 140 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 95/210 (45%), Gaps = 35/210 (16%) Query: 350 FADLNYGPVDQAGESPAY-QAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKM 408 ADLN+ ++P + + DA K WI G+DG+R+DAVKH+ + K Sbjct: 193 LADLNH-------QNPVIDRYLKDAVKMWIDMGIDGIRMDAVKHMPFG--------WQKS 237 Query: 409 FYEDMNAYYKQKGHTDDFYMIGEVL---SEYDKVAPYY---KGLPALFEFSFWYRLEWGI 462 ++++ Y + GE +E D Y+ G+ +L +F F +L + Sbjct: 238 LMDEIDNYRP-------VFTFGEWFLSENEVDANNHYFANESGM-SLLDFRFGQKLRQVL 289 Query: 463 NNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLT 522 N++ ++ + + Q + Y + T + NHD DR G K +A AVLLT Sbjct: 290 RNNSDNWYGFNQM-IQDTASAYDEVLDQVTFIDNHDMDRFMID-GGDPRKVDMALAVLLT 347 Query: 523 SAGHPYIYYGEELGLYGTKDNGDEYVRSPM 552 S G P IYYG E + G NGD R M Sbjct: 348 SRGVPNIYYGTEQYMTG---NGDPNNRKMM 374 >4CGT-A nrPDB Length = 678 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 35/143 (24%) Query: 51 PDTWDETKRA---DISYQLLLYSFADSD------GDGY------------GDLNGVTQKL 89 PDT K++ D+ YQ+ F D + G Y GD G+ K+ Sbjct: 2 PDTAVTNKQSFSTDVIYQVFTDRFLDGNPSNNPTGAAYDATCSNLKLYCGGDWQGLINKI 61 Query: 90 D--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNPQLGTESDFDRL 135 + Y + LGV ALW+S P+ + YHGY D+ K NP GT +DF L Sbjct: 62 NDNYFSDLGVTALWISQPVENIFATINYSGVTNTAYHGYWARDFKKTNPYFGTMADFQNL 121 Query: 136 VTEAHNRGIKIYLDYVMNHTGTA 158 +T AH +GIKI +D+ NHT A Sbjct: 122 ITTAHAKGIKIVIDFAPNHTSPA 144 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 83/317 (26%), Positives = 128/317 (40%), Gaps = 46/317 (14%) Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKG-HTDDFYMIG 430 DA K W+ GVDG+R+DAVKH+ P + + M++ Y K T + +G Sbjct: 207 DAIKLWLDMGVDGIRVDAVKHM---------PLGWQKSW--MSSIYAHKPVFTFGEWFLG 255 Query: 431 EVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIE 490 S+ D K +L +F F + ++T +A D + +Y + Sbjct: 256 SAASDADNTDFANKSGMSLLDFRFNSAVRNVFRDNTSNMYALDSM-INSTATDYNQVNDQ 314 Query: 491 ATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRS 550 T + NHD DR + + + + A A LTS G P IYYG E L G NGD R+ Sbjct: 315 VTFIDNHDMDRFKTS-AVNNRRLEQALAFTLTSRGVPAIYYGTEQYLTG---NGDPDNRA 370 Query: 551 PMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMT 610 M +++ T A N+ L LR + PA+A G+ Sbjct: 371 KM-------PSFSKSTTA-------------------FNVISKLAPLRKSNPAIAYGSTQ 404 Query: 611 KHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPL---TDKIEKVLFVNGET 667 + + N+ + K + + N L + G + LP TD + VL N T Sbjct: 405 QRWINNDVYVYERKFGKSVAVVAVNRNLSTSASITGLSTSLPTGSYTDVLGGVLNGNNIT 464 Query: 668 QQNTDSDSYTLKLGGYA 684 N +++TL G A Sbjct: 465 STNGSINNFTLAAGATA 481 >3UEQ-A nrPDB Length = 632 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 4/108 (3%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPC---MSYHGYDVTDYTKVNPQLGTESDFDRLV 136 GDL G+ K+ Y +LG+ L L P+ C S GY V+ Y VNP LGT D ++ Sbjct: 114 GDLKGLKDKIPYFQELGLTYLHLMPLFKCPEGKSDGGYAVSSYRDVNPALGTIGDLREVI 173 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPK 184 H GI +D++ NHT H W + ++ + + N+Y D + Sbjct: 174 AALHEAGISAVVDFIFNHTSNEHEW-AQRCAAGDPLFDNFYYIFPDRR 220 Score = 30.0 bits (66), Expect = 4.0, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 20/34 (58%) Query: 509 SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKD 542 + D+ KL ++ L++ G P IY G+E+G D Sbjct: 468 AVDRIKLLYSIALSTGGLPLIYLGDEVGTLNDDD 501 >3VM7-A nrPDB Length = 492 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 48/149 (32%), Positives = 68/149 (45%), Gaps = 27/149 (18%) Query: 49 ASPDTWDETKRADISYQLLLYSFADSDGD------------GYGDLNGVTQKLDYLNQLG 96 A+PD W R+ YQ+L FA DG G+ G+ +LDY+ +G Sbjct: 22 ATPDEW----RSRSIYQVLTDRFARGDGSPDAPCDTGARKYCGGNYRGLISQLDYIQGMG 77 Query: 97 VKALWLSPIHPCMS-------YHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLD 149 ++W+SPI YHGY TD +N GTE D L E H RG+ + +D Sbjct: 78 FDSVWISPITKQFEDDWNGAPYHGYWQTDLYALNEHFGTEEDLRALADELHARGMFLMVD 137 Query: 150 YVMNHTGTAHPWFTEASSSSESPYRNYYS 178 V+NH G W +A+S S + + S Sbjct: 138 VVINHNG----WPGDAASIDYSQFNPFNS 162 >6AIJ-A nrPDB Length = 708 Score = 68.6 bits (166), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/163 (32%), Positives = 73/163 (44%), Gaps = 38/163 (23%) Query: 40 VEGQWTALTASPDTWDETK---RADISYQLLLYSFADSD------GDGY----------- 79 + G T ASPDT + K D+ YQ++ FAD D GD + Sbjct: 12 LAGFATVAQASPDTSVDNKVNFSTDVIYQIVTDRFADGDRTNNPAGDAFSGDRSNLKLYF 71 Query: 80 -GDLNGVTQKLD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNP 124 GD G+ K++ YL +GV ALW+S P+ S YHGY D+ + N Sbjct: 72 GGDWQGIIDKINDGYLTGMGVTALWISQPVENITSVIKYSGVNNTSYHGYWARDFKQTND 131 Query: 125 QLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA---HPWFTE 164 G +DF L+ AH IK+ +D+ NHT A +P F E Sbjct: 132 AFGDFADFQNLIDTAHAHNIKVVIDFAPNHTSPADRDNPGFAE 174 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/247 (25%), Positives = 96/247 (38%), Gaps = 52/247 (21%) Query: 377 WIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEY 436 W+ GVDG+R DAVKH+ F+ Y + + T + +G ++ Sbjct: 239 WLGMGVDGIRFDAVKHMPFGWQKS----FVSSIYGGDHPVF-----TFGEWYLGADQTDG 289 Query: 437 DKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDI----LSYQQKYANYRSDYIE-- 490 D + + L +F + + + T KD+ S + +Y DYI Sbjct: 290 DNIKFANESGMNLLDFEYAQEVREVFRDKTETM--KDLYEVLASTESQY-----DYINNM 342 Query: 491 ATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRS 550 T + NHD DR G + A A+ LTS G P IYYG E + G +GD R+ Sbjct: 343 VTFIDNHDMDRFQVA-GSGTRATEQALALTLTSRGVPAIYYGTEQYMTG---DGDPNNRA 398 Query: 551 PMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMT 610 M ++ TT Y + +L LR + PA+A G T Sbjct: 399 MMTSFNTGTTAY--------------------------KVIQALAPLRKSNPAIAYGTTT 432 Query: 611 KHSVYNE 617 + V N+ Sbjct: 433 ERWVNND 439 >3EDF-A nrPDB Length = 601 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 32/80 (40%), Positives = 46/80 (57%), Gaps = 4/80 (5%) Query: 89 LDYLNQLGVKALWLSPI----HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGI 144 LDY+ LG LW +P+ SYHGY TD+ +++P+ G+ DF RL TEA RG+ Sbjct: 154 LDYIAGLGFTQLWPTPLVENDAAAYSYHGYAATDHYRIDPRYGSNEDFVRLSTEARKRGM 213 Query: 145 KIYLDYVMNHTGTAHPWFTE 164 + D V++H G H W + Sbjct: 214 GLIQDVVLSHIGKHHWWMKD 233 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 24/52 (46%) Query: 495 SNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDE 546 NHD R S G+ D+ ++ L+T P Y G+E+ + T D+ Sbjct: 415 GNHDMARMFSAAGEDFDRWRMNLVFLMTMPRIPQFYSGDEILMTSTVKGRDD 466 >3DHU-A nrPDB Length = 449 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 19/118 (16%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHG----- 113 R ++ Y + + +++++ G+ GVT L + LG LWL PI+P + Sbjct: 11 RNEMIYSVFVRNYSEA-----GNFAGVTADLQRIKDLGTDILWLLPINPIGEVNRKGTLG 65 Query: 114 --YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT------GTAHP-WF 162 Y + DY +NP+ GT +DF L AH G+K+ LD V NHT T HP WF Sbjct: 66 SPYAIKDYRGINPEYGTLADFKALTDRAHELGMKVMLDIVYNHTSPDSVLATEHPEWF 123 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 27/58 (46%), Gaps = 1/58 (1%) Query: 478 QQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEEL 535 Q++ A + +Y++ L NHD R S + A+ + + G P IY G+E Sbjct: 258 QRQDATFPGNYVKMRFLENHDNARMMSLMHSKAEAVNNLTWIFM-QRGIPLIYNGQEF 314 >4JCM-A nrPDB Length = 702 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 36/87 (41%), Positives = 49/87 (56%), Gaps = 11/87 (12%) Query: 80 GDLNGVTQKLD--YLNQLGVKALWLSP-------IHP--CMSYHGYDVTDYTKVNPQLGT 128 GD G+ +++ YL +G+ ALW+SP +HP SYHGY D+ K NP G Sbjct: 80 GDWQGIIDEIESGYLPDMGITALWISPPVENVFDLHPEGFSSYHGYWARDFKKTNPFFGD 139 Query: 129 ESDFDRLVTEAHNRGIKIYLDYVMNHT 155 DF RL+ AH IK+ +D+V NHT Sbjct: 140 FDDFSRLIETAHAHDIKVVIDFVPNHT 166 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 84/201 (41%), Gaps = 32/201 (15%) Query: 370 IADAAKGWIARGVDGLRLDAVKHI-------YHSETSEENPRFLKMFYEDMNAYYKQKGH 422 + ++ + W+ G+DG+R+DAV H+ + S + NP F F E Sbjct: 230 LKESIQLWLDTGIDGIRVDAVAHMPLGWQKAFISSVYDYNPVF--TFGE----------- 276 Query: 423 TDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYF-AKDILSYQQKY 481 + G S + G+ AL +F + + + N G D+L+ Q Sbjct: 277 ----WFTGAQGSNHYHHFVNNSGMSAL-DFRYAQVAQDVLRNQKGTMHDIYDMLASTQ-- 329 Query: 482 ANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTK 541 +Y + T + NHD DR + + G+ + A LLTS G P IYYG E + G Sbjct: 330 LDYERPQDQVTFIDNHDIDRFTVE-GRDTRTTDIGLAFLLTSRGVPAIYYGTENYMTGKG 388 Query: 542 DNGDEYVRSPMLWGDSYTTNY 562 D G+ R M D TT Y Sbjct: 389 DPGN---RKMMESFDQTTTAY 406 >5H05-A nrPDB Length = 640 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 37/114 (32%), Positives = 56/114 (49%), Gaps = 23/114 (20%) Query: 64 YQLLLYSFADSD-----GDGYG------DLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH 112 YQ+++ SF + D G GYG DL G+ LDY+ LG+ A+WL+PI + Sbjct: 17 YQVMVESFVNGDDAIGHGTGYGTSHHKGDLQGIIDSLDYIESLGMNAIWLTPIFDSIPVE 76 Query: 113 GYD------------VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNH 154 G D ++Y V+P+ GT LV +AH +G+ ++ D V H Sbjct: 77 GQDHWADRLDATGYFTSNYFAVDPRFGTMEQAKELVEKAHEKGLYVFFDGVFGH 130 Score = 33.9 bits (76), Expect = 0.27, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 81/202 (40%), Gaps = 33/202 (16%) Query: 444 KGLPAL---FEFSFWYRL-------EWGINNSTGCYFAKDILSYQQKYANYRSDYIEATK 493 +G PAL F+F YR+ E GI N G + + ++ + Y ++ + Sbjct: 238 EGEPALCSAFDFPVRYRVVETFAANENGIGNKGGKWLDEG-MNLHRLYPSHAQPNL---M 293 Query: 494 LSNHDEDRTSSKLGKSA----------DKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN 543 L NHD R L + ++ K A + +G +YYGEE+G D Sbjct: 294 LGNHDLVRFGDLLQRGNIASPEQAEYWERHKAALSFQAAYSGPITLYYGEEIG-----DE 348 Query: 544 GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFS-LTRLRNTYP 602 + Y + + D D A S N+ + + L Y S L LR +P Sbjct: 349 LEGYAQK--VEQDCAVQGLCDDHVARTSANIDGLTVNLNEKQRDLKQYVSQLMTLRAAHP 406 Query: 603 ALAEGNMTKHSVYNESQEKDYK 624 AL+ G T + V NE+ D+K Sbjct: 407 ALSRGERT-NIVANETVYIDHK 427 >1EO7-A nrPDB Length = 686 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 49/153 (32%), Positives = 69/153 (45%), Gaps = 38/153 (24%) Query: 50 SPDTWDETKR---ADISYQLLLYSFADSDG---------DGY---------GDLNGVTQK 88 +PDT K+ D+ YQ+ F+D + DG GD G+ K Sbjct: 1 APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGTCTNLRLYCGGDWQGIINK 60 Query: 89 LD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNPQLGTESDFDR 134 ++ YL +GV A+W+S P+ S YHGY D+ K NP GT +DF Sbjct: 61 INDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGYWARDFKKTNPAYGTIADFQN 120 Query: 135 LVTEAHNRGIKIYLDYVMNHTGTA---HPWFTE 164 L+ AH + IK+ +D+ NHT A P F E Sbjct: 121 LIAAAHAKNIKVIIDFAPNHTSPASSDQPSFAE 153 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/185 (30%), Positives = 84/185 (45%), Gaps = 19/185 (10%) Query: 370 IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 + DA K W+ G+DG+R+ AVKH+ + K F +N Y F + Sbjct: 211 LKDAIKMWLDLGIDGIRMAAVKHMPFG--------WQKSFMAAVNNYKPVFTFGAWFLGV 262 Query: 430 GEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGI-NNSTGCYFAKDILSYQQKYANYRSDY 488 EV E K A G+ +L +F F ++ +N+ Y K +L + A+Y Sbjct: 263 NEVSPENHKFA-NESGM-SLLDFRFAQKVRQVFRDNTDNMYGLKAML--EGSAADYAQVD 318 Query: 489 IEATKLSNHDEDRTSSKLGKSADKCKL--AAAVLLTSAGHPYIYYGEELGLYGTKDNGDE 546 + T + NHD +R + +A++ KL A A LTS G P IYYG E + G D D Sbjct: 319 DQVTFIDNHDMERFHA---SNANRRKLEQALAFTLTSRGVPAIYYGTEQYMSGGTDP-DN 374 Query: 547 YVRSP 551 R P Sbjct: 375 RARIP 379 >3CZE-A nrPDB Length = 644 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 56/106 (52%), Gaps = 4/106 (3%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH---GYDVTDYTKVNPQLGTESDFDRLV 136 G L GV +++ YL +LGV+ L L P + G+ V+DY +V P LG+ D L Sbjct: 103 GTLQGVAERVPYLQELGVRYLHLLPFLRARAGDNDGGFAVSDYGQVEPSLGSNDDLVALT 162 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSED 182 + GI + D+V+NHT H W +A+ + ++ Y +YY D Sbjct: 163 SRLREAGISLCADFVLNHTADDHAW-AQAARAGDARYLDYYHHFAD 207 >4AYS-A nrPDB Length = 648 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 42/106 (39%), Positives = 53/106 (50%), Gaps = 4/106 (3%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH---GYDVTDYTKVNPQLGTESDFDRLV 136 G L GV ++L+YL LGV L L P+ GY V DY V P LGT D L Sbjct: 103 GTLRGVGERLEYLEGLGVTYLHLLPLLRPRDGENDGGYAVQDYRSVRPDLGTIDDLSALA 162 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSED 182 E RGI + LD V+NH H W A ++ E+ YR+Y+ D Sbjct: 163 RELRGRGISLVLDLVLNHVAEEHEWAVRA-TAGEAAYRDYFHIFPD 207 >6IRT-A nrPDB Length = 647 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 56/106 (52%), Gaps = 6/106 (5%) Query: 76 GDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDV--TDYTKVNPQLGTESDFD 133 G G G+L G+ +LDYL+ L VK L L PIH DV TD +++P G++ DFD Sbjct: 250 GHGAGNLAGLKGRLDYLSSLKVKGLVLGPIH---KNQKDDVAQTDLLQIDPNFGSKEDFD 306 Query: 134 RLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSF 179 L+ A + I++ LD N+ G + WF+ + + ++ F Sbjct: 307 SLLQSAKKKSIRVILDLTPNYRGE-NSWFSTQVDTVATKVKDALEF 351 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 62/140 (44%), Gaps = 12/140 (8%) Query: 510 ADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDAT 569 A +L +L T G P YG+E+GL G MLW +S ++ D A Sbjct: 462 AQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDES---SFPDIPGA- 517 Query: 570 VSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAW 629 VS N+ TV Q D SLL+++ L+ R+ +L G+ S + + I W Sbjct: 518 VSANM-TVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFS----AGPGLFSYIRHW 572 Query: 630 YMTKDNEKLLVIHNFGGTAM 649 NE+ LV+ NFG + Sbjct: 573 ---DQNERFLVVLNFGDVGL 589 >1EHA-A nrPDB Length = 558 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/141 (34%), Positives = 65/141 (46%), Gaps = 11/141 (7%) Query: 22 ACSDDKNITDPAPEPEPP-VEGQWTALTASPDTWDET--KRAD-ISYQLLLYSFADSDGD 77 D I DPA +P V G + S + +ET K+ D I Y++ + +F Sbjct: 59 VLDDASEIPDPASRYQPEGVHGPSQIIQESKEFNNETFLKKEDLIIYEIHVGTFTPE--- 115 Query: 78 GYGDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRL 135 G GV +KLDYL LG+ A+ + PI P GYD V G F +L Sbjct: 116 --GTFEGVIRKLDYLKDLGITAIEIMPIAQFPGKRDWGYDGVYLYAVQNSYGGPEGFRKL 173 Query: 136 VTEAHNRGIKIYLDYVMNHTG 156 V EAH +G+ + LD V NH G Sbjct: 174 VDEAHKKGLGVILDVVYNHVG 194 Score = 32.7 bits (73), Expect = 0.54, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 107/296 (36%), Gaps = 71/296 (23%) Query: 287 WGL----LIRTSNASFWPSGTKYGASSSSEK-LALNKDFKLTNAGNPANIMFDSQQITYF 341 WG L N+ P G + + +K L + D + G N M + YF Sbjct: 150 WGYDGVYLYAVQNSYGGPEGFRKLVDEAHKKGLGVILDVVYNHVGPEGNYMV--KLGPYF 207 Query: 342 HSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAV--------KH 392 + T W N+ D A + I + + WI VDG RLDAV KH Sbjct: 208 SQKYKTPWGLTFNF---DDAESDEVRKFILENVEYWIKEYNVDGFRLDAVHAIIDTSPKH 264 Query: 393 IYH--------------SETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDK 438 I +E+ +PR + ++ Y DDF+ Sbjct: 265 ILEEIADVVHKYNRIVIAESDLNDPRVVNP--KEKVGYNIDAQWVDDFHH---------S 313 Query: 439 VAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRS------------ 486 + Y G E +Y +++ Y KD+ Y KY+N+R Sbjct: 314 IHAYLTG-----ERQGYYTDFGNLDDIVKSY--KDVFVYDGKYSNFRRKTHGEPVGELDG 366 Query: 487 -DYIEATKLSNHDEDRTSSK---LGKSADK--CKLAAAVLLTSAGHPYIYYGEELG 536 +++ + NHD+ K + K D+ K+AAA+ L S P I+ GEE G Sbjct: 367 CNFV--VYIQNHDQVGNRGKGERIIKLVDRESYKIAAALYLLSPYIPMIFMGEEYG 420 >2DH2-A nrPDB Length = 424 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 56/106 (52%), Gaps = 6/106 (5%) Query: 76 GDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDV--TDYTKVNPQLGTESDFD 133 G G G+L G+ +LDYL+ L VK L L PIH DV TD +++P G++ DFD Sbjct: 29 GHGAGNLAGLKGRLDYLSSLKVKGLVLGPIH---KNQKDDVAQTDLLQIDPNFGSKEDFD 85 Query: 134 RLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSF 179 L+ A + I++ LD N+ G + WF+ + + ++ F Sbjct: 86 SLLQSAKKKSIRVILDLTPNYRGE-NSWFSTQVDTVATKVKDALEF 130 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 62/140 (44%), Gaps = 12/140 (8%) Query: 510 ADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDAT 569 A +L +L T G P YG+E+GL G MLW +S ++ D A Sbjct: 241 AQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDES---SFPDIPGA- 296 Query: 570 VSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAW 629 VS N+ TV Q D SLL+++ L+ R+ +L G+ S + + I W Sbjct: 297 VSANM-TVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFS----AGPGLFSYIRHW 351 Query: 630 YMTKDNEKLLVIHNFGGTAM 649 NE+ LV+ NFG + Sbjct: 352 ---DQNERFLVVLNFGDVGL 368 >1V3M-A nrPDB Length = 686 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/153 (31%), Positives = 67/153 (43%), Gaps = 38/153 (24%) Query: 50 SPDTWDETKR---ADISYQLLLYSFADSDG---------DGY---------GDLNGVTQK 88 +PDT K+ D+ YQ+ F+D + DG GD G+ K Sbjct: 1 APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGSCTNLRLYCGGDWQGIINK 60 Query: 89 LD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNPQLGTESDFDR 134 ++ YL +G+ A+W+S P+ S YHGY D+ K NP GT DF Sbjct: 61 INDGYLTGMGITAIWISQPVENIYSVINYSGVNNTAYHGYWARDFKKTNPAYGTMQDFKN 120 Query: 135 LVTEAHNRGIKIYLDYVMNHTGTAH---PWFTE 164 L+ AH IK+ +D+ NHT A P F E Sbjct: 121 LIDTAHAHNIKVIIDFAPNHTSPASSDDPSFAE 153 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 15/183 (8%) Query: 370 IADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 + DA K W+ GVDG+R+DAVKH+ + K F +N Y + F + Sbjct: 211 LKDAIKMWLDLGVDGIRVDAVKHMPFG--------WQKSFMATINNYKPVFTFGEWFLGV 262 Query: 430 GEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGI-NNSTGCYFAKDILSYQQKYANYRSDY 488 E+ EY + A G+ +L ++ F + +N+ Y K +L + +Y Sbjct: 263 NEISPEYHQFA-NESGM-SLLDYRFAQKARQVFRDNTDNMYGLKAMLEGSE--VDYAQVN 318 Query: 489 IEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYV 548 + T + NHD +R + G K + A A LTS G P IYYG E + G D D Sbjct: 319 DQVTFIDNHDMERFHTSNGDRR-KLEQALAFTLTSRGVPAIYYGSEQYMSGGND-PDNRA 376 Query: 549 RSP 551 R P Sbjct: 377 RLP 379 >1A47-A nrPDB Length = 683 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 41/131 (31%), Positives = 60/131 (45%), Gaps = 33/131 (25%) Query: 61 DISYQLLLYSFADSD------GDGY------------GDLNGVTQKLD--YLNQLGVKAL 100 D+ YQ++ F D + GD Y GD G+ K++ YL +GV A+ Sbjct: 15 DVIYQIVTDRFVDGNTSNNPTGDLYDPTHTSLKKYFGGDWQGIINKINDGYLTGMGVTAI 74 Query: 101 WLS-PIHPC------------MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIY 147 W+S P+ SYHGY D+ + NP G+ +DF L+ AH IK+ Sbjct: 75 WISQPVENIYAVLPDSTFGGSTSYHGYWARDFKRTNPYFGSFTDFQNLINTAHAHNIKVI 134 Query: 148 LDYVMNHTGTA 158 +D+ NHT A Sbjct: 135 IDFAPNHTSPA 145 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 89/334 (26%), Positives = 131/334 (39%), Gaps = 77/334 (23%) Query: 340 YFHSHFCTDW-------------FADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 YFH + TD+ ADLN Q +Y + A K W+ G+DG+R Sbjct: 175 YFHHYGGTDFSSYEDGIYRNLFDLADLN----QQNSTIDSY--LKSAIKVWLDMGIDGIR 228 Query: 387 LDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVL---SEYDKVAPYY 443 LDAVKH+ + K F + + +Y + GE +E D Y+ Sbjct: 229 LDAVKHMPFG--------WQKNFMDSILSYRP-------VFTFGEWFLGTNEIDVNNTYF 273 Query: 444 ---KGLPALFEFSFWYRLEWGINNSTGCYFAKD--ILSYQQKYANYRSDYIEATKLSNHD 498 G+ +L +F F ++ ++T + D I S Y N+ +D + T + NHD Sbjct: 274 ANESGM-SLLDFRFSQKVRQVFRDNTDTMYGLDSMIQSTASDY-NFINDMV--TFIDNHD 329 Query: 499 EDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSY 558 DR + G S + A A LTS G P IYYG E + G NGD Y R+ M ++ Sbjct: 330 MDRFYN--GGSTRPVEQALAFTLTSRGVPAIYYGTEQYMTG---NGDPYNRAMMTSFNTS 384 Query: 559 TTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNES 618 TT Y N+ L LR + PA+A G + + N+ Sbjct: 385 TTAY--------------------------NVIKKLAPLRKSNPAIAYGTTQQRWINNDV 418 Query: 619 QEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLP 652 + K + N L +N G LP Sbjct: 419 YIYERKFGNNVALVAINRNLSTSYNITGLYTALP 452 >2WPG-A nrPDB Length = 637 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 35/106 (33%), Positives = 54/106 (50%), Gaps = 4/106 (3%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH---GYDVTDYTKVNPQLGTESDFDRLV 136 G L GV +++ YL +LGV+ L L P + G+ V+DY +V P LG+ D L Sbjct: 104 GTLRGVAERVPYLQELGVRYLHLLPFLRARAGDNDGGFAVSDYGQVEPALGSNDDLVALT 163 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSED 182 I + D+V+NHT H W +A+ + ++ Y +YY D Sbjct: 164 ARLRAANISLCADFVLNHTADDHAW-AQAARAGDTRYLDYYHHFAD 208 >1IV8-A nrPDB Length = 720 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 5/82 (6%) Query: 78 GYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM--SYHGYDVTDYTKVNPQLGTESDFDRL 135 +GD V L Y LGV L+LSP+ S HGYDV D++++N +LG E ++ RL Sbjct: 15 NFGD---VIDNLWYFKDLGVSHLYLSPVLMASPGSNHGYDVIDHSRINDELGGEKEYRRL 71 Query: 136 VTEAHNRGIKIYLDYVMNHTGT 157 + AH G+ I D V NH Sbjct: 72 IETAHTIGLGIIQDIVPNHMAV 93 >2TAA-A nrPDB Length = 478 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 40/128 (31%), Positives = 56/128 (43%), Gaps = 24/128 (18%) Query: 49 ASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN------------GVTQKLDYLNQLG 96 A+P W R+ Y LL FA +DG N G+ KLDY+ +G Sbjct: 1 ATPADW----RSQSIYFLLTDRFARTDGSTTATCNTADQKYCGGTWQGIIDKLDYIQGMG 56 Query: 97 VKALWLSPI-----HPCM---SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL 148 A+W++P+ C +Y GY TD +N GT D L + H RG+ + + Sbjct: 57 FTAIWITPVTAQLPQDCAYGDAYTGYWQTDIYSLNENYGTADDLKALSSALHERGMYLMV 116 Query: 149 DYVMNHTG 156 D V NH G Sbjct: 117 DVVANHMG 124 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 47/166 (28%), Positives = 68/166 (40%), Gaps = 30/166 (18%) Query: 382 VDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVL-SEYDKVA 440 +DGLR+D VKH+ K F+ Y K G Y IGEVL + Sbjct: 200 IDGLRIDTVKHVQ------------KDFWP---GYNKAAG----VYCIGEVLDGDPAYTC 240 Query: 441 PYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS----N 496 PY + + + +Y L +++G + D L +SD ++T L N Sbjct: 241 PYQNVMDGVLNYPIYYPLLNAFKSTSG---SMDDL--YNMINTVKSDCPDSTLLGTFVEN 295 Query: 497 HDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKD 542 HD R +S A +AA ++L G P IY G+E G D Sbjct: 296 HDNPRFASYTNDIALAKNVAAFIILND-GLPIIYAGQEQHYAGGND 340 >4GKL-A nrPDB Length = 422 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 18/123 (14%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCMSYHG--------YDVTDYTKVNPQLGTESDFDRLV 136 + + L+ L +G+ +WL PIHP G Y + DY +++ +GT+ DF + V Sbjct: 27 LEKDLERLKGMGINTVWLMPIHPT-GVEGRKGTLGSPYAIRDYYEIDLLIGTKGDFKKFV 85 Query: 137 TEAHNRGIKIYLDYVMNHTGT------AHP-WFTEASSSSESPYRNYYSFSEDPKTDIAA 189 AH + + +D V+NH HP WF + +P R +S+ D + Sbjct: 86 KRAHELNMYVLMDMVLNHAAVDNVLVKKHPEWFLRDENG--NPTRKVPDWSDVVDFDYSN 143 Query: 190 GKI 192 G++ Sbjct: 144 GEL 146 Score = 33.5 bits (75), Expect = 0.32, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 43/108 (39%), Gaps = 5/108 (4%) Query: 441 PY-YKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDE 499 PY Y+ +++ +YR I D L Q Y YI+ L NHD+ Sbjct: 201 PYMYQAFDITYDYDGYYRFRDFIEGKNSLREYIDFLRMQDHM--YPRGYIKMRFLENHDQ 258 Query: 500 DRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEY 547 R + L S + A L T G P ++ G+E L D +EY Sbjct: 259 PRVAKFL--SRESLMHWIAFLFTVKGVPLVHNGQEYALKEDLDIFNEY 304 >5CIM-A nrPDB Length = 698 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 54/138 (39%), Gaps = 27/138 (19%) Query: 53 TWDETKRADIS--YQLLLYSFADSDGDG---YGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 W + A S Y++ S D +G +G + L + ++G ++L PIHP Sbjct: 219 VWVDRPEARFSSWYEMFPRSTGGWDAEGRPVHGTFATAAEALPRIARMGFDVVYLPPIHP 278 Query: 108 CMSYH---------------------GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 H G D + V+PQLGT DFD V A + G+++ Sbjct: 279 IGKVHRKGRNNSVTAAPGDVGSPWAIGSDEGGHDAVHPQLGTIEDFDEFVASARDLGLEV 338 Query: 147 YLDYVMNHTGTAHPWFTE 164 LD + HPW E Sbjct: 339 ALDLAL-QCAPDHPWARE 355 >2AAA-A nrPDB Length = 484 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 8/87 (9%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCM--------SYHGYDVTDYTKVNPQLGTESD 131 G G+ LDY+ +G A+W+SPI + +YHGY VN GT + Sbjct: 40 GSWQGIIDHLDYIEGMGFTAIWISPITEQLPQDTADGEAYHGYWQQKIYDVNSNFGTADN 99 Query: 132 FDRLVTEAHNRGIKIYLDYVMNHTGTA 158 L H RG+ + +D V +H G A Sbjct: 100 LKSLSDALHARGMYLMVDVVPDHMGYA 126 >4OKD-A nrPDB Length = 840 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 27/103 (26%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIH-----------PCMSYHGYDVTDYTKVN----- 123 G G+ ++LDYL LGV A+ L P+ P + ++ Y+ VN Sbjct: 246 GTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIPGSDQYRFNFWGYSTVNYFSPM 305 Query: 124 -----------PQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 P + +F +LV E H RGI++ LD V NHT Sbjct: 306 GRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVVFNHT 348 >4CN6-A nrPDB Length = 695 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 22/105 (20%) Query: 79 YGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH-----------GYDVT---------- 117 +G ++L + +G ++L PIHP + H G DV Sbjct: 249 HGTFRTAARRLPAIAAMGFDVVYLPPIHPIGTTHRKGRNNTLSATGDDVGVPWAIGSPEG 308 Query: 118 DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWF 162 + ++P LGT DFD VTEA G++I LD+ + HPW Sbjct: 309 GHDSIHPALGTLDDFDHFVTEAGKLGLEIALDFALQ-CSPDHPWV 352 >4U33-A nrPDB Length = 723 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 41/161 (25%) Query: 64 YQLLLYSFADSDGDG---YGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH-------- 112 Y++ S D DG +G +L + +G ++L PIHP H Sbjct: 257 YEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHPIGKVHRKGRNNSP 316 Query: 113 -------------GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH 159 G D + V+P LGT DFD V+ A + G+++ LD + H Sbjct: 317 TAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEVALDLALQ-CAPDH 375 Query: 160 P-------WFTEASSSS----ESPYRNY-----YSFSEDPK 184 P WFTE + E+P + Y +F DP+ Sbjct: 376 PWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPE 416 >1BF2-A nrPDB Length = 750 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 25/131 (19%) Query: 56 ETKRADISYQLLLYSFADSD----GDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS- 110 ++ D+ Y++ + F + D G G K YL LGV A+ P+ + Sbjct: 174 RAQKDDVIYEVHVRGFTEQDTSIPAQYRGTYYGAGLKASYLASLGVTAVEFLPVQETQND 233 Query: 111 -------------YHGYDVTDYTKVNPQL-------GTESDFDRLVTEAHNRGIKIYLDY 150 Y GY +Y + + G ++F +V HN GIK+Y+D Sbjct: 234 ANDVVPNSDANQNYWGYMTENYFSPDRRYAYNKAAGGPTAEFQAMVQAFHNAGIKVYMDV 293 Query: 151 VMNHTGTAHPW 161 V NHT W Sbjct: 294 VYNHTAEGGTW 304 >2BHU-A nrPDB Length = 602 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 8/106 (7%) Query: 54 WDETKRAD-ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH 112 W K AD + Y++ + +F G +KL YL +LGV A+ + P+ Sbjct: 119 WHGIKLADCVFYEVHVGTFTPE-----GTYRAAAEKLPYLKELGVTAIQVMPLAAFDGQR 173 Query: 113 G--YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTG 156 G YD + G D LV AH G+ ++LD V NH G Sbjct: 174 GWGYDGAAFYAPYAPYGRPEDLMALVDAAHRLGLGVFLDVVYNHFG 219 >4UZU-A nrPDB Length = 513 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 11/85 (12%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCMS--------YHGYDVTDYTK---VNPQLGTESDFD 133 V + + L+ LG+ ALWL P + S Y YD+ ++ + V + GT++ + Sbjct: 26 VANEANNLSSLGITALWLPPAYKGTSRSDVGYGVYDLYDLGEFNQKGTVRTKYGTKAQYL 85 Query: 134 RLVTEAHNRGIKIYLDYVMNHTGTA 158 + + AH G+++Y D V +H G A Sbjct: 86 QAIQAAHAAGMQVYADVVFDHKGGA 110 >3M07-A nrPDB Length = 618 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 59/156 (37%), Gaps = 11/156 (7%) Query: 12 WLSMLMAFMT-------ACSDDKNITDPAPEPEPP-VEGQWTALTASPDTWDETK-RADI 62 W ++ +A +T SD + DPA + V G + TW T + Sbjct: 74 WFTLDVAGVTPGTEYNFVLSDGMVVPDPASRAQKTDVNGPSYVVDPGSYTWRNTGWKGSR 133 Query: 63 SYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHG--YDVTDYT 120 Q ++Y G KL YL +LGV + + P+ G YD Sbjct: 134 WEQAVVYEMHTGTFTPEGTFRAAIAKLPYLAELGVTVIEVMPVAQFGGERGWGYDGVLLY 193 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTG 156 + GT DF + AH G+ + LD V+NH G Sbjct: 194 APHSAYGTPDDFKAFIDAAHGYGLSVVLDIVLNHFG 229 >3BH4-A nrPDB Length = 483 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 11/80 (13%) Query: 90 DYLNQLGVKALWLSPIHPCMS--------YHGYDVTDYTK---VNPQLGTESDFDRLVTE 138 ++L+ +G+ A+W+ P + +S Y YD+ ++ + V + GT+S+ + Sbjct: 28 EHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQKGTVRTKYGTKSELQDAIGS 87 Query: 139 AHNRGIKIYLDYVMNHTGTA 158 H+R +++Y D V+NH A Sbjct: 88 LHSRNVQVYGDVVLNHKAGA 107 >2YA2-A nrPDB Length = 708 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 41/147 (27%) Query: 79 YGDLNGVTQKLDYLNQLGVKALWLSPI-----------HPCMSYH---------GYDVTD 118 +G +KLDYL LGV + L P+ H +S + GYD + Sbjct: 177 FGTFEAFIEKLDYLKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQN 236 Query: 119 YTKV---------NPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS 169 Y + NP+ ++F L+ E H RG+ LD V NHT + Sbjct: 237 YFSLTGMYSSDPKNPEKRI-AEFKNLINEIHKRGMGAILDVVYNHTAKVDLF-------- 287 Query: 170 ESPYRNYYSFSE---DPKTDIAAGKIA 193 E NYY F + P+T G++ Sbjct: 288 EDLEPNYYHFMDADGTPRTSFGGGRLG 314 >1E3X-A nrPDB Length = 483 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 11/80 (13%) Query: 90 DYLNQLGVKALWLSPIHPCMS--------YHGYDVTDYTK---VNPQLGTESDFDRLVTE 138 ++L+ +G+ A+W+ P + +S Y YD+ ++ + V + GT+S+ + Sbjct: 28 EHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQKGTVRTKYGTKSELQDAIGS 87 Query: 139 AHNRGIKIYLDYVMNHTGTA 158 H+R +++Y D V+NH A Sbjct: 88 LHSRNVQVYGDVVLNHKAGA 107 >2D3L-A nrPDB Length = 485 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 14/96 (14%) Query: 74 SDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTKVNPQ--- 125 +DG+ + LN L G+ A+W+ P S Y YD+ D + N + Sbjct: 19 NDGNHWNRLNSDASNLK---SKGITAVWIPPAWKGASQNDVGYGAYDLYDLGEFNQKGTV 75 Query: 126 ---LGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 GT S VT N GI++Y D VMNH G A Sbjct: 76 RTKYGTRSQLQAAVTSLKNNGIQVYGDVVMNHKGGA 111 Score = 29.3 bits (64), Expect = 5.9, Method: Compositional matrix adjust. Identities = 12/20 (60%), Positives = 16/20 (80%) Query: 381 GVDGLRLDAVKHIYHSETSE 400 G+DG R+DAVKHI +S T + Sbjct: 229 GLDGFRIDAVKHIKYSFTRD 248 >1MXD-A nrPDB Length = 435 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 38/82 (46%), Gaps = 12/82 (14%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCMS---YHGYDVTDY---------TKVNPQLGTESDF 132 + K+ + G+ A+WL P MS GYD DY V + G++ + Sbjct: 30 IRSKIPEWYEAGISAIWLPPPSKGMSGGYSMGYDPYDYFDLGEYYQKGTVETRFGSKEEL 89 Query: 133 DRLVTEAHNRGIKIYLDYVMNH 154 RL+ AH GIK+ D V+NH Sbjct: 90 VRLIQTAHAYGIKVIADVVINH 111 >3K1D-A nrPDB Length = 722 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 2/67 (2%) Query: 90 DYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIY 147 DY+ G + L P+ HP GY VT Y + GT DF LV H GI + Sbjct: 271 DYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVI 330 Query: 148 LDYVMNH 154 +D+V H Sbjct: 331 VDWVPAH 337 >2DIE-A nrPDB Length = 485 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 11/78 (14%) Query: 92 LNQLGVKALWLSPIHPCMS-----YHGYDVTDYTKVNPQ------LGTESDFDRLVTEAH 140 L G+ A+W+ P S Y YD+ D + N + GT S VT Sbjct: 34 LKSKGITAVWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGTVRTKYGTRSQLQGAVTSLK 93 Query: 141 NRGIKIYLDYVMNHTGTA 158 N GI++Y D VMNH G A Sbjct: 94 NNGIQVYGDVVMNHKGGA 111 >1BPL-A nrPDB Length = 189 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 11/79 (13%) Query: 91 YLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------VNPQLGTESDFDRLVTEA 139 YL + G+ A+W+ P + S Y YD+ D + V + GT+ + + Sbjct: 31 YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSL 90 Query: 140 HNRGIKIYLDYVMNHTGTA 158 H+R I +Y D V+NH G A Sbjct: 91 HSRDINVYGDVVINHKGGA 109 >1BLI-A nrPDB Length = 483 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 11/79 (13%) Query: 91 YLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------VNPQLGTESDFDRLVTEA 139 YL + G+ A+W+ P + S Y YD+ D + V + GT+ + + Sbjct: 31 YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSL 90 Query: 140 HNRGIKIYLDYVMNHTGTA 158 H+R I +Y D V+NH G A Sbjct: 91 HSRDINVYGDVVINHKGGA 109 >6GXV-A nrPDB Length = 484 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 11/75 (14%) Query: 91 YLNQLGVKALWLSPIHPCMS--------YHGYDVTDYTK---VNPQLGTESDFDRLVTEA 139 +L +G+ +W P + S Y YD+ ++ + V + GT++ +T Sbjct: 33 HLKSIGITGVWFPPAYKGQSQSDVGYGVYDMYDLGEFNQKGTVRTKYGTKAQLQSAITSL 92 Query: 140 HNRGIKIYLDYVMNH 154 HN GI+ Y D V+NH Sbjct: 93 HNNGIQAYGDVVLNH 107 >2GJP-A nrPDB Length = 485 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 11/78 (14%) Query: 92 LNQLGVKALWLSPIHPCMS-----YHGYDVTDYTKVNPQ------LGTESDFDRLVTEAH 140 L G+ A+W+ P S Y YD+ D + N + GT S + + Sbjct: 34 LRNRGITAIWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGTVRTKYGTRSQLESAIHALK 93 Query: 141 NRGIKIYLDYVMNHTGTA 158 N G+++Y D VMNH G A Sbjct: 94 NNGVQVYGDVVMNHKGGA 111 Score = 28.9 bits (63), Expect = 7.7, Method: Compositional matrix adjust. Identities = 42/162 (25%), Positives = 74/162 (45%), Gaps = 23/162 (14%) Query: 382 VDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYM--IGEVLSEYDKV 439 +DG R+DAVKHI +S T + NA K+ +F+ +G + + +K Sbjct: 230 LDGFRIDAVKHIKYSFTRD-------WLTHVRNATGKEMFAVAEFWKNDLGALENYLNKT 282 Query: 440 APYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDIL--SYQQKYANYRSDYIEATKLSNH 497 + ++F+ Y L + +NS G Y +L + QK+ + +++ NH Sbjct: 283 NWNH----SVFDVPLHYNL-YNASNSGGNYDMAKLLNGTVVQKHPMHAVTFVD-----NH 332 Query: 498 DEDRTSSKLGKSADKCK-LAAAVLLT-SAGHPYIYYGEELGL 537 D S + K LA A++LT G+P ++YG+ G+ Sbjct: 333 DSQPGESLESFVQEWFKPLAYALILTREQGYPSVFYGDYYGI 374 >3BCF-A nrPDB Length = 599 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 12/84 (14%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIHPCMS------YHGYDVTDYTK------VNPQLGTES 130 N + ++ L + G A+WL P + M+ Y YD+ D + V + GT+ Sbjct: 150 NLLAERAPELAEAGFTAVWLPPANKGMAGIHDVGYGTYDLWDLGEFDQKGTVRTKYGTKG 209 Query: 131 DFDRLVTEAHNRGIKIYLDYVMNH 154 + + + HN IK+Y D V+NH Sbjct: 210 ELENAIDALHNNDIKVYFDAVLNH 233 Score = 33.1 bits (74), Expect = 0.36, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 68/162 (41%), Gaps = 23/162 (14%) Query: 377 WIARGVD--GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEV-L 433 WI +D G RLDAVKHI + RF+ + M+A Q D + +GE + Sbjct: 337 WIINNIDFDGFRLDAVKHIDY--------RFIDKW---MSAV--QNSSNRDVFFVGEAWV 383 Query: 434 SEYDKVAPYYK--GLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 + D + + G P L F F R + ++ G Y A + Y + + Sbjct: 384 EDVDDLKGFLDTVGNPDLRVFDFPLR-SFFVDMLNGAYMADLRNAGLVNSPGYENRAV-- 440 Query: 492 TKLSNHDEDRTSSKLGKS--ADKCKLAAAVLLTSAGHPYIYY 531 T + NHD DR S + K + A +L + G P +Y+ Sbjct: 441 TFVDNHDTDRDEGSYTVSIYSRKYQAYAYILTRAEGVPTVYW 482 >1UA7-A nrPDB Length = 422 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 11/85 (12%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIHPC---------MS--YHGYDVTDYTKVNPQLGTES 130 N + + ++ G A+ SPI+ MS Y Y T Y N LGTE Sbjct: 16 FNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWLYQPTSYQIGNRYLGTEQ 75 Query: 131 DFDRLVTEAHNRGIKIYLDYVMNHT 155 +F + A GIK+ +D V+NHT Sbjct: 76 EFKEMCAAAEEYGIKVIVDAVINHT 100 >5GQY-A nrPDB Length = 793 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 2/68 (2%) Query: 89 LDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 + Y+ +G + L PI HP GY VT + + G DF V + H GI + Sbjct: 322 IPYVKDMGYTHIELLPIAEHPFDGSWGYQVTGFYSPTSRFGRPEDFMYFVDKCHENGIGV 381 Query: 147 YLDYVMNH 154 LD+V H Sbjct: 382 ILDWVPGH 389 >2VNC-A nrPDB Length = 718 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 18/91 (19%) Query: 87 QKLDYLNQLGVKALWLSPIHPCM-----------SYHGYDVTD-------YTKVNPQLGT 128 Q + YL LG+ + L P+ + +Y GYD + Y+ G Sbjct: 206 QMISYLKDLGITTVELMPVFHFIDQRFLTDKGLTNYWGYDPINFFSPECRYSSTGCLGGQ 265 Query: 129 ESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH 159 F ++V E HN GI++ +D V NHT + Sbjct: 266 VLSFKKMVNELHNAGIEVIIDVVYNHTAEGN 296 >3QGV-A nrPDB Length = 435 Score = 37.7 bits (86), Expect = 0.017, Method: Compositional matrix adjust. Identities = 27/119 (22%), Positives = 53/119 (44%), Gaps = 22/119 (18%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCMS---------YHGYDVTDYTK---VNPQLGTESDF 132 + QK+ G+ A+W+ P M Y +D+ +Y + V + G++ + Sbjct: 30 IRQKIPEWYDAGISAIWIPPASKGMGGAYSMGYDPYDFFDLGEYDQKGTVETRFGSKQEL 89 Query: 133 DRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGK 191 ++ AH G+K+ D V+NH +P+ N Y++++ K +A+GK Sbjct: 90 VNMINTAHAYGMKVIADIVINHRA--------GGDLEWNPFVNDYTWTDFSK--VASGK 138 >1UD8-A nrPDB Length = 480 Score = 37.4 bits (85), Expect = 0.025, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 13/90 (14%) Query: 92 LNQLGVKALWLSPIHPCMS-----YHGYDVTDYTKVNPQ------LGTESDFDRLVTEAH 140 L+ G+ A+W+ P + S Y YD+ D + N + GT++ +R + Sbjct: 32 LSDAGITAIWIPPAYKGNSQADVGYGAYDLYDLGEFNQKGTVRTKYGTKAQLERAIGSLK 91 Query: 141 NRGIKIYLDYVMNHTGTAHPWFTEASSSSE 170 + I +Y D VMNH A FTEA + + Sbjct: 92 SNDINVYGDVVMNHKMGAD--FTEAVQAVQ 119 Score = 32.7 bits (73), Expect = 0.52, Method: Compositional matrix adjust. Identities = 48/171 (28%), Positives = 72/171 (42%), Gaps = 41/171 (23%) Query: 382 VDGLRLDAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTDDFYM--IGEVLS 434 +DG RLDA+KHI TS + N +F + Y+K +FY+ + +S Sbjct: 225 LDGYRLDAIKHIPFWYTSDWVRHQRNEADQDLFV--VGEYWKDDVGALEFYLDEMNWEMS 282 Query: 435 EYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA--- 491 +D +P + F YR + G Y ++IL R +EA Sbjct: 283 LFD--------VPLNYNF---YR----ASQQGGSYDMRNIL---------RGSLVEAHPM 318 Query: 492 ---TKLSNHDEDRTSSKLGKSADKCK-LAAAVLLT-SAGHPYIYYGEELGL 537 T + NHD S AD K LA A +LT G+P ++YG+ G+ Sbjct: 319 HAVTFVDNHDTQPGESLESWVADWFKPLAYATILTREGGYPNVFYGDYYGI 369 >5E70-A nrPDB Length = 612 Score = 37.0 bits (84), Expect = 0.026, Method: Compositional matrix adjust. Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 2/73 (2%) Query: 87 QKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGI 144 Q + Y +G L L PI HP GY T + GT DF + AH G+ Sbjct: 155 QLVPYAKWMGFTHLELLPINEHPFDGSWGYQPTGLYAPTRRFGTRDDFRYFIDAAHAAGL 214 Query: 145 KIYLDYVMNHTGT 157 + LD+V H T Sbjct: 215 NVILDWVPGHFPT 227 >3AMK-A nrPDB Length = 702 Score = 37.0 bits (84), Expect = 0.032, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 27/43 (62%) Query: 113 GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 GY VT++ V+ + GT D LV +AH+ G+++ +D V +H Sbjct: 234 GYHVTNFFAVSSRSGTPEDLKYLVDKAHSLGLRVLMDVVHSHA 276 >3FAW-A nrPDB Length = 877 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 58/147 (39%), Gaps = 44/147 (29%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH----------------------GYDVT 117 G ++KLDYL +LGV + L P+ +SY GYD Sbjct: 293 GTFAAFSEKLDYLQKLGVTHIQLLPV---LSYFYVNEMDKSRSTAYTSSDNNYNWGYDPQ 349 Query: 118 DYTKVNPQLGTE--------SDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS 169 Y ++ + ++ +L+ + H RG+ + LD V NHT + + Sbjct: 350 SYFALSGMYSEKPKDPSARIAELKQLIHDIHKRGMGVILDVVYNHTAKTYLF-------- 401 Query: 170 ESPYRNYYSF-SED--PKTDIAAGKIA 193 E NYY F +ED P+ G++ Sbjct: 402 EDIEPNYYHFMNEDGSPRESFGGGRLG 428 >1MFU-A nrPDB Length = 491 Score = 36.6 bits (83), Expect = 0.038, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 9/72 (12%) Query: 91 YLNQLGVKALWLSPIHPCMSYHG--------YDVTDYTKVNPQLGTESDFDRLVTEAHNR 142 YL G + +SP + ++ H Y Y K+ + G E +F +VT +N Sbjct: 31 YLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSY-KLCTRSGNEDEFRNMVTRCNNV 89 Query: 143 GIKIYLDYVMNH 154 G++IY+D V+NH Sbjct: 90 GVRIYVDAVINH 101 >3L2M-A nrPDB Length = 496 Score = 36.2 bits (82), Expect = 0.046, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 24/34 (70%) Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNH 154 K+ + G E++F +VT +N G++IY+D V+NH Sbjct: 68 KLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINH 101 >3DC0-A nrPDB Length = 422 Score = 36.2 bits (82), Expect = 0.046, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 11/85 (12%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIHPCMS-----------YHGYDVTDYTKVNPQLGTES 130 N + + ++ G A+ SPI+ Y Y T Y N LG+E Sbjct: 16 FNTLKNNMKDIHDAGYTAIQTSPINQVKEGNKGDKSMGNWYWLYQPTSYQIGNRYLGSEE 75 Query: 131 DFDRLVTEAHNRGIKIYLDYVMNHT 155 +F + A G+K+ +D V+NHT Sbjct: 76 EFKEMCAAAEEYGVKVIVDAVINHT 100 >3WN6-A nrPDB Length = 404 Score = 35.8 bits (81), Expect = 0.060, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 1/78 (1%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNP-QLGTESDFDRLVTEAHN 141 N + K+D + G+ +WL P + GY ++ + G E+ L+ H Sbjct: 21 NFLMGKVDDIAAAGITHVWLPPPSHSVGEQGYMPGRLYDLDASKYGNEAQLKSLIEAFHG 80 Query: 142 RGIKIYLDYVMNHTGTAH 159 +G+++ D V+NH H Sbjct: 81 KGVQVIADIVINHRTAEH 98 >6JEQ-A nrPDB Length = 675 Score = 35.4 bits (80), Expect = 0.093, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 23/95 (24%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIH--------------PCMSYHGYDVTDYTKVNPQLGT 128 NG+ LD++ LGV + L PI+ P ++ GYD +Y T Sbjct: 192 NGIPTGLDHITGLGVTHVQLLPIYDYSQESVDESRLDEPHYNW-GYDPQNYNVPEGSYST 250 Query: 129 ES--------DFDRLVTEAHNRGIKIYLDYVMNHT 155 + + RL+ + H RG+++ +D V NH Sbjct: 251 DPHNPAARILELKRLIQKLHARGLRVIMDVVYNHV 285 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 10/66 (15%) Query: 487 DYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDE 546 D IE + DE+R + +LA+A++LTS G P+++ G+E TK + Sbjct: 476 DKIELSTPGASDEERRAMH--------RLASAIVLTSQGIPFLHAGQE--FMRTKGGVEN 525 Query: 547 YVRSPM 552 +SP+ Sbjct: 526 SYKSPI 531 >1AVA-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.099, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 1/78 (1%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNP-QLGTESDFDRLVTEAHN 141 N + K+D + G+ +WL P ++ GY ++ + G ++ L+ H Sbjct: 20 NFLMGKVDDIAAAGITHVWLPPASQSVAEQGYMPGRLYDLDASKYGNKAQLKSLIGALHG 79 Query: 142 RGIKIYLDYVMNHTGTAH 159 +G+K D V+NH H Sbjct: 80 KGVKAIADIVINHRTAEH 97 >3WDH-A nrPDB Length = 710 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 41/113 (36%), Gaps = 24/113 (21%) Query: 83 NGVTQKLDYLNQLGVKALWLSPI---------HPCMSYH-GYDVTDYTKVNPQLGTESD- 131 NG L Y+ QLGV + L P+ P Y+ GY+ Y T+ D Sbjct: 258 NGTLTGLSYIKQLGVTHVQLMPVQDFEGVDELQPLKMYNWGYNTVHYNAPEGSYATDPDD 317 Query: 132 -------FDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYY 177 R + GI++ LD V NH + +SS E YY Sbjct: 318 PYARIIELKRAIRAFQQEGIRVILDVVYNHV------YVRETSSFEHLVPGYY 364 >3BSH-A nrPDB Length = 414 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 1/73 (1%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNP-QLGTESDFDRLVTEAHN 141 N + K+D + GV +WL P +S GY ++ + G ++ L+ H Sbjct: 21 NMMMGKVDDIAAAGVTHVWLPPPSHSVSNEGYMPGRLYDIDASKYGNAAELKSLIGALHG 80 Query: 142 RGIKIYLDYVMNH 154 +G++ D V+NH Sbjct: 81 KGVQAIADIVINH 93 >2WSK-A nrPDB Length = 657 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 23/113 (20%) Query: 89 LDYLNQLGVKALWLSPIHPCMS-----------YHGYDVTDYTKVNPQLGTESD-----F 132 ++YL QLG+ AL L P+ S Y GY+ ++P + F Sbjct: 185 INYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEF 244 Query: 133 DRLVTEAHNRGIKIYLDYVMNHTGTAH---PWFTEASSSSESPYRNYYSFSED 182 + H GI++ LD V+NH+ P F+ + R+YY ED Sbjct: 245 RDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDN----RSYYWIRED 293 >5CLW-A nrPDB Length = 668 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%) Query: 89 LDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 L + LG + L I H + GY +T + + + G+ + LV AH+ GI + Sbjct: 192 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGSPEELQELVDTAHSMGIIV 251 Query: 147 YLDYVMNHT 155 LD V +H Sbjct: 252 LLDVVHSHA 260 >3THX-B nrPDB Length = 918 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 14/81 (17%) Query: 375 KGWIARGVDGLR-----LDAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTD 424 K W+ + + LR LDAV + HSE+S E + R L + + Y +K T Sbjct: 361 KKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQ 420 Query: 425 DFYMIGEVL----SEYDKVAP 441 +F++I + L SE+ + P Sbjct: 421 EFFLIVKTLYHLKSEFQAIIP 441 >1TMQ-A nrPDB Length = 471 Score = 32.7 bits (73), Expect = 0.54, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 26/47 (55%) Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSS 168 +N + G ES F + ++ G++IY+D V+NH + T SS+ Sbjct: 67 INTRSGDESAFTDMTRRCNDAGVRIYVDAVINHMTGMNGVGTSGSSA 113 >5J6H-A nrPDB Length = 302 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 29/51 (56%) Query: 174 RNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDETAAVKGLLKF 224 R+Y + +ED KT AA A+IT+ AAE+++ E V+ LL++ Sbjct: 122 RDYIALNEDLKTWTAADVAAIITRRKWEQAGAAEYYRAYLEAECVEWLLRY 172 >5JBE-A nrPDB Length = 854 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 34/81 (41%), Gaps = 9/81 (11%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIHPCMSY----HGYDVTDY----TKVNP-QLGTESDFD 133 N + + + LG+ W++P + GY +TD T NP + G+ + Sbjct: 644 NVIAKNASLFSDLGITDFWMAPAYTPFGRSRYNEGYSMTDRYNLGTTANPTKYGSGEELA 703 Query: 134 RLVTEAHNRGIKIYLDYVMNH 154 + H G+K+ D VMN Sbjct: 704 NTIAALHKAGLKVQEDIVMNQ 724 >6MDV-A nrPDB Length = 802 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 2/67 (2%) Query: 380 RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKV 439 RGVDGL +D + T EE+ R L +F E K ++ LS + Sbjct: 134 RGVDGLDIDIEHEFTNKRTPEEDARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSVENN- 192 Query: 440 APYYKGL 446 P +KG+ Sbjct: 193 -PIFKGI 198 >5N4B-A nrPDB Length = 731 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 11/87 (12%) Query: 576 TVADQQADTHSLL-----NIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 ++A++Q TH L N ++ R T P ++ + + NE D++ WY Sbjct: 407 SIANRQKQTHFFLTLSGFNTPGTIARYDFTAPETQRFSILRTTKVNELDPDDFESTQVWY 466 Query: 631 MTKDNEKL---LVIH---NFGGTAMQL 651 +KD K+ +V H F GTA + Sbjct: 467 ESKDGTKIPMFIVRHKSTKFDGTAAAI 493 >2X7Q-A nrPDB Length = 321 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 14/30 (46%), Positives = 18/30 (60%) Query: 545 DEYVRSPMLWGDSYTTNYTDKTDATVSKNV 574 D YV+SP+LW S +N D TDA K + Sbjct: 92 DTYVKSPLLWAVSTGSNRDDVTDAKQLKRI 121 >3VM5-A nrPDB Length = 505 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 11/32 (34%), Positives = 20/32 (62%) Query: 127 GTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 G E++ ++T +N G+ +Y+D V+NH A Sbjct: 74 GGENELRDMITRCNNVGVNVYVDAVINHMCGA 105 >2E8Y-A nrPDB Length = 718 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 42/92 (45%), Gaps = 20/92 (21%) Query: 83 NGVTQKLDYLNQLGVKALWLSPIH---------PCMSYH-GYDVTDY---------TKVN 123 NG + L Y+ +LGV + L P++ P +Y+ GY+ + + Sbjct: 251 NGSSSGLAYVKELGVTHVELLPVNDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHD 310 Query: 124 PQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 PQ +++ +++ H G+++ LD V NH Sbjct: 311 PQT-RKTELKQMINTLHQHGLRVILDVVFNHV 341 >5FR8-A nrPDB Length = 733 Score = 29.6 bits (65), Expect = 4.7, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 33/73 (45%), Gaps = 9/73 (12%) Query: 54 WDETKRADISYQLLLYSFADSDGDGYGDL---NGVTQKLDYLNQLGVKALWLSPIHPCMS 110 W+ T +A L+ F S G +GD+ N T +D ++ L L PI+ S Sbjct: 572 WENTPKA------LIQGFEGSLGLDFGDIRWTNNFTYMMDSKDKQTGNPLSLVPIYTINS 625 Query: 111 YHGYDVTDYTKVN 123 YD+TD VN Sbjct: 626 IFDYDITDQLDVN 638 >6MRE-A nrPDB Length = 420 Score = 29.3 bits (64), Expect = 5.3, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 3/38 (7%) Query: 120 TKVNPQLGTESDFDRLVTEAHNRGIKIYLD---YVMNH 154 T V+ LGTE+ ++T AH G K+ +D VM+H Sbjct: 185 THVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHH 222 >5C8B-B nrPDB Length = 514 Score = 29.3 bits (64), Expect = 6.8, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 30/58 (51%), Gaps = 5/58 (8%) Query: 113 GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSE 170 G+D D+TKV+ +LG+ D L ++ HN I +D ++NH F + + E Sbjct: 54 GFDPIDHTKVDERLGSWDDVAEL-SKTHN----IMVDAIVNHMSWESKQFQDVLAKGE 106 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3K8L-A nrPDB 963 0.0 1UOK-A nrPDB 269 4e-72 4AIE-A nrPDB 267 1e-71 3WY1-A nrPDB 259 3e-69 1WZA-A nrPDB 257 1e-68 4HOX-A nrPDB 256 2e-68 5H2T-A nrPDB 253 2e-67 3GBE-A nrPDB 253 2e-67 4LXF-A nrPDB 252 3e-67 5DO8-B nrPDB 252 3e-67 2ZIC-A nrPDB 252 4e-67 5BRQ-A nrPDB 248 6e-66 5WCZ-A nrPDB 246 2e-65 2ZE0-A nrPDB 245 4e-65 5ZCD-A nrPDB 245 7e-65 3ZO9-A nrPDB 243 2e-64 5YKB-A nrPDB 240 2e-63 1SMA-A nrPDB 239 3e-63 5X7U-A nrPDB 237 1e-62 1M53-A nrPDB 234 1e-61 1J0H-A nrPDB 233 2e-61 4GI8-A nrPDB 223 3e-58 4CGT-A nrPDB 219 4e-57 1V3M-A nrPDB 219 4e-57 1A47-A nrPDB 215 6e-56 1EO7-A nrPDB 211 7e-55 1CYG-A nrPDB 206 3e-53 1EA9-C nrPDB 203 2e-52 1JL8-A nrPDB 191 7e-49 3AXH-A nrPDB 188 9e-48 2WC7-A nrPDB 187 2e-47 5M99-B nrPDB 181 6e-46 1LWJ-A nrPDB 179 3e-45 6AIJ-A nrPDB 176 2e-44 1QHO-A nrPDB 175 5e-44 5OT1-A nrPDB 170 2e-42 4JCM-A nrPDB 168 5e-42 4E2O-A nrPDB 166 4e-41 5A2B-A nrPDB 162 5e-40 6A0L-A nrPDB 160 2e-39 3M07-A nrPDB 160 2e-39 5BN7-A nrPDB 159 3e-39 3HJE-A nrPDB 157 2e-38 4AEF-A nrPDB 157 2e-38 1EHA-A nrPDB 154 9e-38 4AEE-A nrPDB 149 3e-36 2Z1K-A nrPDB 148 9e-36 5Z0U-A nrPDB 144 9e-35 3UER-A nrPDB 133 2e-31 3VM7-A nrPDB 132 4e-31 6IRT-A nrPDB 126 3e-29 2BHU-A nrPDB 123 3e-28 2DH2-A nrPDB 123 3e-28 3UEQ-A nrPDB 122 4e-28 3CZE-A nrPDB 122 5e-28 2WPG-A nrPDB 122 5e-28 2TAA-A nrPDB 120 1e-27 4AYS-A nrPDB 118 8e-27 3DHU-A nrPDB 117 1e-26 5ZCR-A nrPDB 117 1e-26 3EDF-A nrPDB 114 2e-25 5H05-A nrPDB 112 5e-25 4U33-A nrPDB 112 6e-25 2AAA-A nrPDB 112 6e-25 5CIM-A nrPDB 107 1e-23 1IV8-A nrPDB 105 4e-23 4GKL-A nrPDB 105 6e-23 2YA2-A nrPDB 104 2e-22 4OKD-A nrPDB 103 3e-22 1BF2-A nrPDB 101 1e-21 4CN6-A nrPDB 94 2e-19 3K1D-A nrPDB 86 6e-17 1E3X-A nrPDB 81 1e-15 1MXD-A nrPDB 81 2e-15 3BH4-A nrPDB 81 2e-15 4UZU-A nrPDB 79 6e-15 1BLI-A nrPDB 78 1e-14 1BPL-A nrPDB 76 4e-14 2D3L-A nrPDB 76 7e-14 6GXV-A nrPDB 74 2e-13 2DIE-A nrPDB 72 6e-13 Sequences not found previously or not previously below threshold: 3FAW-A nrPDB 97 2e-20 2VNC-A nrPDB 90 3e-18 5E70-A nrPDB 84 2e-16 6JEQ-A nrPDB 80 3e-15 5GQY-A nrPDB 79 5e-15 3QGV-A nrPDB 78 1e-14 2WSK-A nrPDB 76 6e-14 1AVA-A nrPDB 72 5e-13 3BCF-A nrPDB 72 8e-13 3WN6-A nrPDB 72 9e-13 3WDH-A nrPDB 71 1e-12 2GJP-A nrPDB 70 4e-12 3BSH-A nrPDB 70 4e-12 2E8Y-A nrPDB 69 7e-12 1UD8-A nrPDB 68 1e-11 2WAN-A nrPDB 66 5e-11 5CLW-A nrPDB 65 1e-10 1TMQ-A nrPDB 61 1e-09 3AMK-A nrPDB 59 5e-09 1GJU-A nrPDB 59 8e-09 1BPL-B nrPDB 58 1e-08 3VM5-A nrPDB 57 2e-08 1MFU-A nrPDB 55 1e-07 1UA7-A nrPDB 54 2e-07 3DC0-A nrPDB 54 2e-07 3AIC-A nrPDB 51 1e-06 5C8B-B nrPDB 51 2e-06 3L2M-A nrPDB 49 8e-06 5JBE-A nrPDB 48 1e-05 1JD7-A nrPDB 46 4e-05 1GCY-A nrPDB 45 1e-04 1QI5-A nrPDB 44 2e-04 4J3X-A nrPDB 44 2e-04 5X3I-A nrPDB 34 0.25 4H54-A nrPDB 34 0.33 5Z01-A nrPDB 33 0.42 2CKS-A nrPDB 33 0.44 5CQF-A nrPDB 33 0.47 2HVA-A nrPDB 33 0.47 3J9M-AO nrPDB 32 0.61 3DUG-A nrPDB 32 0.87 4ML9-A nrPDB 32 1.1 6MDV-A nrPDB 32 1.3 1QVB-A nrPDB 31 1.4 6MRE-A nrPDB 31 1.6 3POC-A nrPDB 31 2.1 1WB0-A nrPDB 31 2.2 5WZN-A nrPDB 31 2.2 4WKA-A nrPDB 30 3.1 4Q6X-A nrPDB 29 6.5 >3K8L-A nrPDB Length = 669 Score = 963 bits (2490), Expect = 0.0, Method: Composition-based stats. Identities = 668/669 (99%), Positives = 669/669 (100%) Query: 24 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN 83 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN Sbjct: 1 SDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLN 60 Query: 84 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG 143 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG Sbjct: 61 GVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRG 120 Query: 144 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY 203 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY Sbjct: 121 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY 180 Query: 204 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE 263 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE Sbjct: 181 NAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGE 240 Query: 264 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT 323 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT Sbjct: 241 DICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLT 300 Query: 324 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD 383 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD Sbjct: 301 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVD 360 Query: 384 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY 443 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY Sbjct: 361 GLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY 420 Query: 444 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTS 503 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNH+EDRTS Sbjct: 421 KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHNEDRTS 480 Query: 504 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT 563 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT Sbjct: 481 SKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYT 540 Query: 564 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY 623 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY Sbjct: 541 DKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY 600 Query: 624 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY 683 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY Sbjct: 601 KPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGY 660 Query: 684 ASVVFKLGN 692 ASVVFKLGN Sbjct: 661 ASVVFKLGN 669 >1UOK-A nrPDB Length = 558 Score = 269 bits (687), Expect = 4e-72, Method: Composition-based stats. Identities = 93/433 (21%), Positives = 152/433 (35%), Gaps = 93/433 (21%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + +D Y+ H + DLN+ Q + + K W+ +G+DG R+D Sbjct: 147 SAWQYDEMTDEYY-LHLFSKKQPDLNWDNE------KVRQDVYEMMKFWLEKGIDGFRMD 199 Query: 389 AVKHIYHSETSEE----------------NPRFLKMFYEDMNAYYKQKGHTDDFYMIGEV 432 + I E N + + +MN ++ D +GE+ Sbjct: 200 VINFISKEEGLPTVETEEEGYVSGHKHFMNGPNIHKYLHEMN---EEVLSHYDIMTVGEM 256 Query: 433 LSEYDKVAPYYKG-----LPALFEFSFWYR-----LEWGINNSTGCYFAKDILSYQQKYA 482 + A Y G L +F+F +W + + +++ +Q+ Sbjct: 257 PGVTTEEAKLYTGEERKELQMVFQFEHMDLDSGEGGKWDVKPCSLLTLKENLTKWQK--- 313 Query: 483 NYRSDYIEATKLSNHDEDRTSSKLGKS----ADKCKLAAAVLLTSAGHPYIYYGEELGLY 538 + +NHD+ R S+ G + K+ A VL G PYIY GEE+G+ Sbjct: 314 ALEHTGWNSLYWNNHDQPRVVSRFGNDGMYRIESAKMLATVLHMMKGTPYIYQGEEIGMT 373 Query: 539 GTKD-----------------------------------NGDEYVRSPMLWGDSYTTNYT 563 + G + R+PM W D +T Sbjct: 374 NVRFESIDEYRDIETLNMYKEKVMERGEDIEKVMQSIYIKGRDNARTPMQWDDQNHAGFT 433 Query: 564 DK-TDATVSKNVKTVADQQA--DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQE 620 TV+ N K + +QA + S+ Y L LR + G+ N S Sbjct: 434 TGEPWITVNPNYKEINVKQAIQNKDSIFYYYKKLIELRKNNEIVVYGSYDLILENNPS-- 491 Query: 621 KDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKI---EKVLFVNGETQQNTDSDSYT 677 I A+ T EKLLVI NF L + I E L ++ +N ++ T Sbjct: 492 -----IFAYVRTYGVEKLLVIANFTAEECIFELPEDISYSEVELLIHNYDVENGPIENIT 546 Query: 678 LKLGGYASVVFKL 690 L+ Y ++VFKL Sbjct: 547 LR--PYEAMVFKL 557 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 53/136 (38%), Positives = 82/136 (60%), Gaps = 1/136 (0%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HG 113 + + + YQ+ SF DS+GDG GDL G+ KLDYL +LG+ +WLSP++ + +G Sbjct: 3 KQWWKESVVYQIYPRSFMDSNGDGIGDLRGIISKLDYLKELGIDVIWLSPVYESPNDDNG 62 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD++DY K+ + GT D+D L+ E H R +K+ +D V+NHT H WF E+ S ++ Y Sbjct: 63 YDISDYCKIMNEFGTMEDWDELLHEMHERNMKLMMDLVVNHTSDEHNWFIESRKSKDNKY 122 Query: 174 RNYYSFSEDPKTDIAA 189 R+YY + + Sbjct: 123 RDYYIWRPGKEGKEPN 138 >4AIE-A nrPDB Length = 549 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 86/423 (20%), Positives = 156/423 (36%), Gaps = 78/423 (18%) Query: 322 LTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARG 381 L +A + + +D + Y+ HF D DLN+ + Q I + W+ +G Sbjct: 141 LKSAFSGSAWKYDERSGQYY-LHFFADQQPDLNW------QNTELRQKIYNMMNFWLDKG 193 Query: 382 VDGLRLDAVKHIYHSE--TSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKV 439 + G R+D ++ I EN L + ++MN K D +GE + K+ Sbjct: 194 IGGFRMDVIELIGKDPDKNIRENGPMLHPYLQEMN---KATFGKRDVMTVGETWNATPKI 250 Query: 440 APYYKGLP-----ALFEFSFW------YRLEWGINNSTGCYFAKDILSYQQKYANYRSDY 488 A Y +F+F + +W + K ++ +Q K + Sbjct: 251 AEEYSDPDRHELSMVFQFENQSLDQQPGKEKWDLKPLDLGELKKVLVKWQTKIDFDHA-- 308 Query: 489 IEATKLSNHDEDRTSSKLGKSADK----CKLAAAVLLTSAGHPYIYYGEELGLYG----- 539 + NHD R S+ G + K+ A +L G PYI+ GEE+G+ Sbjct: 309 WNSLFWENHDIPRVISRWGNDQEYRVQCAKMFAIILHMMHGTPYIFNGEEIGMTNCPVKN 368 Query: 540 -----------------------------TKDNGDEYVRSPMLWGDSYTTNYTDK-TDAT 569 G + R PM W D +++ + Sbjct: 369 IDEVEDIESINMYNERLAEGYDEEELIHAINVKGRDNARRPMQWNDEKNAGFSEVDPWLS 428 Query: 570 VSKNVK--TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIA 627 V+ N K V + AD +S+ Y L +LR+ P + +G+ + S ++ + Sbjct: 429 VNPNYKDINVENALADPNSIFYTYQKLIKLRHENPIVVDGDFSLVSNTQDA-------VL 481 Query: 628 AWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVV 687 A+Y +++K LV+ N D+IE +L + ++ + L Y + + Sbjct: 482 AYYRILNDKKWLVVANLSNEEQNFVSNDQIETIL-----SNYPERNNVQNITLKPYEAFI 536 Query: 688 FKL 690 K+ Sbjct: 537 SKV 539 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 54/135 (40%), Positives = 81/135 (60%), Gaps = 1/135 (0%) Query: 56 ETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-YHGY 114 + + YQ+ SF DS+GDG GDL G+ +LDYL +LG+ A+WLSP++ +GY Sbjct: 5 SWWKNAVVYQVYPKSFQDSNGDGIGDLQGIISRLDYLEKLGIDAIWLSPVYQSPGVDNGY 64 Query: 115 DVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYR 174 D++DY ++PQ GT +D D L+++A IKI +D V+NHT H WF EA ++ YR Sbjct: 65 DISDYEAIDPQYGTMADMDELISKAKEHHIKIVMDLVVNHTSDQHKWFVEAKKGKDNQYR 124 Query: 175 NYYSFSEDPKTDIAA 189 +YY + + Sbjct: 125 DYYIWRDPVDEHEPN 139 >3WY1-A nrPDB Length = 538 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 96/415 (23%), Positives = 158/415 (38%), Gaps = 78/415 (18%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + FDS++ Y+ +F T D+N+ A QA D + W+ GVDG RLD Sbjct: 150 SAWTFDSRRQQYYLHNFLTS-QPDVNFH------HPEARQAQLDNMRFWLDLGVDGFRLD 202 Query: 389 AVKHIYHSETSEENPRFLKM-----FYEDMNAYYKQKGHTD-----------------DF 426 V +H +NP K + N Y Q+ D D Sbjct: 203 TVNFYFHDAELRDNPPVPKGEAKTLGAPEANPYTWQRHVYDLSRPENLDFLKDLRALMDE 262 Query: 427 Y----MIGEVLSEYD--KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK 480 Y +GE+ + ++A Y G L ++ + L +N + ++++ Q+ Sbjct: 263 YPGTTTVGEIGDDNPLERMAEYTAGGDKL-HMAYTFDL---LNMPHSASYLREVIERFQR 318 Query: 481 YANYRSDYIEATKLSNHDEDRTSSKLGKSADK---CKLAAAVLLTSAGHPYIYYGEELGL 537 A D SNHD R++++ G D K+ AVL + G +Y GEELGL Sbjct: 319 LA---GDAWPCWATSNHDVVRSATRWGADEDPHAYPKVMLAVLFSLRGSVCLYQGEELGL 375 Query: 538 YGTKDN-----------------GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVK----T 576 G + R+PM W D ++ + + Sbjct: 376 PEADVPFERIQDPYGKVLWPEFKGRDGCRTPMPWTDGEQGGFSPVEP-WLPMEARHLELA 434 Query: 577 VADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNE 636 V+ QQ D ++ LN +L R ++PAL +G+++ V ++ + + K +E Sbjct: 435 VSRQQDDPNATLNTVRALLAFRRSHPALFDGDLSLVDVGDD--------LLGFTRQKGDE 486 Query: 637 KLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 LL + N G Q L ++ L V T D TL L Y + ++ Sbjct: 487 TLLCVFNLTGQEQQTTLPVEVASDLPVAHFTATR---DGSTLTLPAYQAAFMQVA 538 Score = 181 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 57/131 (43%), Positives = 81/131 (61%), Gaps = 2/131 (1%) Query: 57 TKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-YHGYD 115 R + YQ+ SF DS GDG GDLNG+T+KLDY+ L V +WLSP GYD Sbjct: 7 WWRGGVIYQIYPRSFLDSRGDGVGDLNGITEKLDYVASLNVDGIWLSPFFTSPMLDFGYD 66 Query: 116 VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRN 175 V+DY V+P GT DF L+ +AH+ G+K+ +D V++HT HPWF E+ + +P + Sbjct: 67 VSDYRDVDPMFGTLEDFKALLEKAHSLGLKVMIDQVISHTSDQHPWFQESRQNRTNPKAD 126 Query: 176 YYSFSEDPKTD 186 ++ ++ DPK D Sbjct: 127 WFVWA-DPKPD 136 >1WZA-A nrPDB Length = 488 Score = 257 bits (657), Expect = 1e-68, Method: Composition-based stats. Identities = 95/379 (25%), Positives = 158/379 (41%), Gaps = 33/379 (8%) Query: 317 NKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG 376 + D K T + + Y + DLNY + + AK Sbjct: 135 DTDTKETKLDGGRVWHYSPTGMYYGY---FWSGMPDLNYN------NPEVQEKVIGIAKY 185 Query: 377 WIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEY 436 W+ +GVDG RLD HI+ ++N + + F +++ Y++GEV Sbjct: 186 WLKQGVDGFRLDGAMHIFPPAQYDKNFTWWEKFRQEIEEVKP-------VYLVGEVWDIS 238 Query: 437 DKVAPYYK-GLPALFEFSFWYRLEWGINNSTGCYF---AKDILSYQQKYANYRSDYIEAT 492 + VAPY+K G + F F + F AK I + + +YI+A Sbjct: 239 ETVAPYFKYGFDSTFNFKLAEAVIATAKAGFPFGFNKKAKHIYGVYDREVGFG-NYIDAP 297 Query: 493 KLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPM 552 L+NHD++R +LG+ +K ++AA++ LT G+P+IYYGEE+G+ G + E +R P Sbjct: 298 FLTNHDQNRILDQLGQDRNKARVAASIYLTLPGNPFIYYGEEIGMRGQGPH--EVIREPF 355 Query: 553 LWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKH 612 W + T A + +V ++ + SLLN Y L RN P G K Sbjct: 356 QWYNGSGEGETYWEPAMYNDGFTSVEQEEKNLDSLLNHYRRLIHFRNENPVFYTG---KI 412 Query: 613 SVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNG--ETQQN 670 + N + A+ D L V HN +++ + +LF +G E Sbjct: 413 EIINGGL-----NVVAFRRYNDKRDLYVYHNLVNRPVKIKVASGNWTLLFNSGDKEITPV 467 Query: 671 TDSDSYTLKLGGYASVVFK 689 D++ + Y ++V + Sbjct: 468 EDNNKLMYTIPAYTTIVLE 486 Score = 191 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 69/142 (48%), Positives = 86/142 (60%), Gaps = 9/142 (6%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYL--------NQLGVKALWLSPIHPCMS 110 + Y++ + SF DSDGDG GDL G+ +KLDYL LGV +WL PI S Sbjct: 3 KHGTYYEIFVRSFYDSDGDGIGDLKGIIEKLDYLNDGDPETIADLGVNGIWLMPIFKSPS 62 Query: 111 YHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSE 170 YHGYDVTDY K+NP GT DF +LV AH RGIK+ +D +NHT HPWF +AS Sbjct: 63 YHGYDVTDYYKINPDYGTLEDFHKLVEAAHQRGIKVIIDLPINHTSERHPWFLKASRDKN 122 Query: 171 SPYRNYYSFSEDPKTDIAAGKI 192 S YR+YY ++ P TD K+ Sbjct: 123 SEYRDYYVWAG-PDTDTKETKL 143 >4HOX-A nrPDB Length = 559 Score = 256 bits (655), Expect = 2e-68, Method: Composition-based stats. Identities = 106/473 (22%), Positives = 160/473 (33%), Gaps = 95/473 (20%) Query: 293 TSNASFWPSGTKYGASSSSEKLALNKDFKLTNAGNP-------ANIMFDSQQITYFHSHF 345 TS+ W +K G ++ +D K +A N + D + Y+ +F Sbjct: 105 TSDQHAWFVQSKSGKNNPYRDYYFWRDGKDGHAPNNYPSFFGGSAWEKDDKSGQYYLHYF 164 Query: 346 CTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEE-NPR 404 DLN+ Q + D + W+ +GV GLR D V + + + Sbjct: 165 -AKQQPDLNWD------NPKVRQDLYDMLRFWLDKGVSGLRFDTVATYSKIPNFPDLSQQ 217 Query: 405 FLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYD-KVAPYYKGLPALFEFSFWYRL----- 458 LK F E+ K + ++ M EVLS YD A G+P F+ R Sbjct: 218 QLKNFAEEYTKGPKIHDYVNE--MNREVLSHYDIATAGEIFGVPLDKSIKFFDRRRNELN 275 Query: 459 ----------------EWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRT 502 W + T F K + Q Y A L NHD R Sbjct: 276 IAFTFDLIRLDRDADERWRRKDWTLSQFRKIVDKVDQTAGEYG---WNAFFLDNHDNPRA 332 Query: 503 SSKLGKSADKC-----KLAAAVLLTSAGHPYIYYGEELGLY------------------- 538 S G + K A + LT P+IY G ELG+ Sbjct: 333 VSHFGDDRPQWREHAAKALATLTLTQRATPFIYQGSELGMTNYPFKKIDDFDDVEVKGFW 392 Query: 539 ----------------GTKDNGDEYVRSPMLWGDSYTTNYTDK-TDATVSKNVKTVA--D 579 + + R+P W S +T ++ N K + D Sbjct: 393 QDYVETGKVKAEEFLQNVRQTSRDNSRTPFQWDASKNAGFTSGTPWLKINPNYKEINSAD 452 Query: 580 QQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLL 639 Q + +S+ N Y L +R+ PAL G+ N S + A+ T EK L Sbjct: 453 QINNPNSVFNYYRKLINIRHDIPALTYGSYIDLDPDNNS-------VYAYTRTLGAEKYL 505 Query: 640 VIHNFGGTAMQLPLTDK--IEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 V+ NF M L I KV+ N + + + L+L + S ++KL Sbjct: 506 VVINFKEEVMHYTLPGDLSINKVITENN-SHTIVNKNDRQLRLEPWQSGIYKL 557 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 54/143 (37%), Positives = 85/143 (59%), Gaps = 5/143 (3%) Query: 48 TASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 A P W + + YQ+ SF D++GDG GDLNG+ + LDYL +LG+ A+W++P + Sbjct: 1 NALPTWW----KQAVFYQVYPRSFKDTNGDGIGDLNGIIENLDYLKKLGIDAIWINPHYD 56 Query: 108 CMS-YHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEAS 166 + +GYD+ DY K+ + GT DFDRL++E R +++ +D V+NHT H WF ++ Sbjct: 57 SPNTDNGYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDIVINHTSDQHAWFVQSK 116 Query: 167 SSSESPYRNYYSFSEDPKTDIAA 189 S +PYR+YY + + Sbjct: 117 SGKNNPYRDYYFWRDGKDGHAPN 139 >5H2T-A nrPDB Length = 601 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 80/381 (20%), Positives = 145/381 (38%), Gaps = 76/381 (19%) Query: 329 ANIMFDS-QQITYFHSHFCTDWFADLNYGPVDQAGESPAYQA-IADAAKGWIARGVDGLR 386 +N +D + Y+H F DLNY ++PA Q + + + W+ G+DG R Sbjct: 165 SNWTYDPVRGQYYWHRFFSHQ--PDLNY-------DNPAVQEAMLEVLRFWLDLGIDGFR 215 Query: 387 LDAVKHIYHSE-TSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKG 445 LDAV ++Y E T+ EN + + + A + D ++ E +++ Y G Sbjct: 216 LDAVPYLYAREGTNCENLPETHAYLKRVRAEVDR--LYPDRVLLAEA-NQWPADVVEYFG 272 Query: 446 LP--------ALFEFSFWYRL--------------------------EWGINNSTGCYFA 471 P F F R+ +WGI Sbjct: 273 DPATGGDECHMAFHFPVMPRIFMAVRREQRYPISEIMAQTPKIPENCQWGIFLRNHDELT 332 Query: 472 KDILSYQQK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPY 528 ++++ +++ YA Y D K + R + L ++ +L A+LL+ G P Sbjct: 333 LEMVTDEERDYMYAEYAKD--PRMKANIGIRRRLAPLLDNDRNQLELFTALLLSLPGSPV 390 Query: 529 IYYGEELGLYGTKDNGD-EYVRSPMLWGDSYTTNYTDKTDAT----------VSKNVKTV 577 +YYG+E+G+ GD + VR+PM W ++ A V Sbjct: 391 LYYGDEIGMGDNIWLGDRDSVRTPMQWTPDRNAGFSRCDPARLYLPVIMDPIYGYQAVNV 450 Query: 578 ADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEK 637 QQ + SLLN + +R +P G+ + N S + A+ +++ Sbjct: 451 EAQQRNPGSLLNWTRKMIEIRKRHPVFGLGSYVELPASNPS-------VLAFVREYGDDR 503 Query: 638 LLVIHNFGGTAMQLPLTDKIE 658 +L ++N + P +++ Sbjct: 504 VLCVNNLS----RFPQPVELD 520 Score = 193 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 63/165 (38%), Positives = 91/165 (55%), Gaps = 8/165 (4%) Query: 48 TASPDTWDETKRAD-------ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKAL 100 PDT+ K D + Y++L+ F+DS+ DG GDL G+ +LDYL LG+ + Sbjct: 6 DPIPDTFTHEKPRDPYWYKHAVFYEVLVRGFSDSNDDGTGDLRGLINRLDYLQWLGIDCI 65 Query: 101 WLSPIHPCM-SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH 159 WL PI+ GYD++DYTK+ P+ G DF LV EAH RGI++ D VMNHT H Sbjct: 66 WLLPIYQSPLRDGGYDISDYTKILPEFGDLGDFVELVDEAHRRGIRVIADLVMNHTSDQH 125 Query: 160 PWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYN 204 PWF + + + PY ++Y +S+ A I + T+ Y+ Sbjct: 126 PWFQASRTDPDGPYGDFYMWSDTDDKYPDARIIFVDTEVSNWTYD 170 >3GBE-A nrPDB Length = 558 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 90/433 (20%), Positives = 145/433 (33%), Gaps = 94/433 (21%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + D + Y+ +F DLN+ Q + + W+ +GV GLR D Sbjct: 147 SAWQKDEKTNQYYLHYF-AKQQPDLNWD------NPKVRQDLYAMLRFWLDKGVSGLRFD 199 Query: 389 AVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFY-----MIGEVLSEYD-KVAPY 442 V T + P F + + + + + + + M EVLS YD A Sbjct: 200 TV------ATYSKIPDFPNLTQQQLKNFAAEYTKGPNIHRYVNEMNKEVLSHYDIATAGE 253 Query: 443 YKGLPALFEFSFWYRL---------------------EWGINNSTGCYFAKDILSYQQKY 481 G+P F+ R W + F + I + + Sbjct: 254 IFGVPLDQSIKFFDRRRDELNIAFTFDLIRLDRDSDQRWRRKDWKLSQFRQIIDNVDRTA 313 Query: 482 ANYRSDYIEATKLSNHDEDRTSSKLGKSADKC-----KLAAAVLLTSAGHPYIYYGEELG 536 Y A L NHD R S G + K A + LT P+IY G ELG Sbjct: 314 GEYG---WNAFFLDNHDNPRAVSHFGDDRPQWREPSAKALATLTLTQRATPFIYQGSELG 370 Query: 537 LY-----------------------------------GTKDNGDEYVRSPMLWGDSYTTN 561 + + + R+P W S Sbjct: 371 MTNYPFKAIDEFDDIEVKGFWHDYVETGKVKADEFLQNVRLTSRDNSRTPFQWDGSKNAG 430 Query: 562 YTD-KTDATVSKNVKTVAD--QQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNES 618 +T K V+ N + + Q S+ N Y L ++R+ PAL G T N+S Sbjct: 431 FTSGKPWFKVNPNYQEINAVSQVTQPDSVFNYYRQLIKIRHDIPALTYGTYTDLDPANDS 490 Query: 619 QEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIE-KVLFVNGETQQNTDSDSYT 677 + A+ + EK LV+ NF M+ L D + + + ++ ++ + Sbjct: 491 -------VYAYTRSLGAEKYLVVVNFKEQMMRYKLPDNLSIEKVIIDSNSKNVVKKNDSL 543 Query: 678 LKLGGYASVVFKL 690 L+L + S V+KL Sbjct: 544 LELKPWQSGVYKL 556 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 52/138 (37%), Positives = 86/138 (62%), Gaps = 1/138 (0%) Query: 53 TWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-Y 111 T + + + YQ+ SF D++GDG GD+NG+ +KLDYL LG+ A+W++P + + Sbjct: 1 TIPKWWKEAVFYQVYPRSFKDTNGDGIGDINGIIEKLDYLKALGIDAIWINPHYDSPNTD 60 Query: 112 HGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSES 171 +GYD+ DY K+ + GT DFDRL++E R +++ +D V+NHT + WF ++ SS ++ Sbjct: 61 NGYDIRDYRKIMKEYGTMEDFDRLISEMKKRNMRLMIDVVINHTSDQNEWFVKSKSSKDN 120 Query: 172 PYRNYYSFSEDPKTDIAA 189 PYR YY + + + Sbjct: 121 PYRGYYFWKDAKEGQAPN 138 >4LXF-A nrPDB Length = 620 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 99/450 (22%), Positives = 164/450 (36%), Gaps = 83/450 (18%) Query: 300 PSGTKYGASSSSEKLALNKDFKLTNAGNPANIMFDS-QQITYFHSHFCTDWFADLNYGPV 358 P G Y S +SE+ + + +N FD ++ Y+H F DLNY Sbjct: 178 PYGDYYVWSDTSERYTDARIIFVDT--EESNWSFDPVRRQFYWHRFFSHQ--PDLNY--- 230 Query: 359 DQAGESPAYQA-IADAAKGWIARGVDGLRLDAVKHIYHSE-TSEENPRFLKMFYEDMNAY 416 ++PA Q + D + W+ G+DG RLDAV +++ E T+ EN + +A+ Sbjct: 231 ----DNPAVQEAMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCEN-------LPETHAF 279 Query: 417 YKQKGHTDDFYMIGEVL----SEYDKVAPYYKGLP--------ALFEFSFWYRL------ 458 K+ D G VL +++ Y G P F F R+ Sbjct: 280 LKRVRKVVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRR 339 Query: 459 --------------------EWGINNSTGCYFAKDILSYQQK---YANYRSDYIEATKLS 495 +WGI ++++ +++ YA Y D K + Sbjct: 340 ESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKD--PRMKAN 397 Query: 496 NHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGD-EYVRSPMLW 554 R + L ++ +L A+LL+ G P +YYG+E+G+ GD + VR PM W Sbjct: 398 VGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQW 457 Query: 555 GDSYTTNYTDK----------TDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPAL 604 ++ D V Q+ + SLLN ++ +R +PA Sbjct: 458 TPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAF 517 Query: 605 AEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEK----V 660 A G + N S + +A D + +L ++N + L + V Sbjct: 518 AVGAFQELGGSNPSVLAYVRQVAG----DDGDTVLCVNNLSRFPQPIELDLQQWTNYTPV 573 Query: 661 LFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 Y L L G+ F+L Sbjct: 574 ELTGHVEFPRIGQVPYLLTLPGHGFYWFQL 603 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 63/164 (38%), Positives = 90/164 (54%), Gaps = 5/164 (3%) Query: 42 GQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALW 101 G AL A P + + Y++L+ +F D+ DG GDL G+ +LDYL LG+ +W Sbjct: 51 GSAAALPADPTWFKHA----VFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIW 106 Query: 102 LSPIHPCM-SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 L P + GYD+ D+ KV P+ GT DF LV AH RGI+I D VMNHT +HP Sbjct: 107 LPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHP 166 Query: 161 WFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYN 204 WF E+ + PY +YY +S+ + A I + T+E ++ Sbjct: 167 WFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESNWSFD 210 >5DO8-B nrPDB Length = 555 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 77/425 (18%), Positives = 143/425 (33%), Gaps = 84/425 (19%) Query: 331 IMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAV 390 D + Y+ H + DLN+ Q + + K W+ +G+DG R+D + Sbjct: 147 WELDEKTGEYY-LHLFSKKQPDLNWE------NPKLRQDVYNMMKFWLDKGIDGFRMDVI 199 Query: 391 KHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFY--MIGEVLSEYDKVA-------- 440 I + + P Y D + +F M EV S+YD + Sbjct: 200 NFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMNQEVTSKYDVMTVGEMPGAS 259 Query: 441 ---------PYYKGLPALFEFSFW-----YRLEWGINNSTGCYFAKDILSYQQKYANYRS 486 P + +F F +W + +++ +Q + Sbjct: 260 TTDAQIYTNPANNEVDMIFTFEHMNLDSDSDNKWDLKPIYLPDLKENMSEWQ---VALQE 316 Query: 487 DYIEATKLSNHDEDRTSSKLGKS----ADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKD 542 + + +NHD+ R S+ G K+ A L G PYIY GEE+G+ Sbjct: 317 NGWNSLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGTPYIYQGEEIGMTNVHF 376 Query: 543 ----------------------------------NGDEYVRSPMLWGDSYTTNYTDK-TD 567 G + R+P W +S +T Sbjct: 377 ETLDDYRDIETLNMYKERKEQGHSHESIMQSIYTKGRDNARTPYQWDNSENAGFTTGTPW 436 Query: 568 ATVSKNVKTVADQQ--ADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKP 625 V+ + +++ + S+ Y +L +LR T + GN +E+ Sbjct: 437 LKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNYRLLLPKDEA------- 489 Query: 626 IAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYAS 685 I A+ +NEKL+V+ NF + + ++ + + TL+ Y + Sbjct: 490 IFAYERYTENEKLVVLCNFTEEEQVISDETILNEIQKGSVLVNNVPNIIEGTLR--PYEA 547 Query: 686 VVFKL 690 +V+++ Sbjct: 548 IVYQI 552 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 53/133 (39%), Positives = 85/133 (63%), Gaps = 1/133 (0%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM-SYHG 113 + + + YQ+ SF DS+GDG GD+ G+ +KLDYL +LGV +WLSP++ +G Sbjct: 4 KDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDNG 63 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD+ DY K+ + G + FD+L+ H+R +K+ +D V+NHT H WF E+ S ++PY Sbjct: 64 YDIRDYQKIYEEYGDMATFDQLLQGLHDRDMKLVMDLVVNHTSDEHKWFEESRKSKDNPY 123 Query: 174 RNYYSFSEDPKTD 186 R+YY + E+ + + Sbjct: 124 RDYYFWREENEIN 136 >2ZIC-A nrPDB Length = 543 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 82/417 (19%), Positives = 137/417 (32%), Gaps = 78/417 (18%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + +D + Y+ HF + DLN+ + Q I D WI +G+ G R+D Sbjct: 142 SAWQYDDKSDQYY-LHFFSKKQPDLNWENAN------LRQKIYDMMNFWIDKGIGGFRMD 194 Query: 389 AVKHIYH--SETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKG- 445 + I ++ N L + ++MNA D +GE ++A Y Sbjct: 195 VIDMIGKIPAQHIVSNGPKLHAYLKEMNA---ASFGQHDLLTVGETWGATPEIAKQYSNP 251 Query: 446 ----LPALFEFSFWYRL------EWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS 495 L +F+F +W K I + Q + + + Sbjct: 252 VNHELSMVFQFEHIGLQHKPEAPKWDYVKELNVPALKTIFNKWQTELELGQGW-NSLFWN 310 Query: 496 NHDEDRTSSKLGK----SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN-------- 543 NHD R S G K A +L G PYIY GEE+G+ Sbjct: 311 NHDLPRVLSIWGNTGKYREKSAKALAILLHLMRGTPYIYQGEEIGMTNYPFKDLNELDDI 370 Query: 544 --------------------------GDEYVRSPMLWGDSYTTNYT--DKTDATVSKNVK 575 G + R+PM W S ++ DKT V+ N K Sbjct: 371 ESLNYAKEAFTNGKSMETIMDSIRMIGRDNARTPMQWDASQNAGFSTADKTWLPVNPNYK 430 Query: 576 TVADQ--QADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTK 633 + Q +++S+ Y L +LR L + + + + A+ Sbjct: 431 DINVQAALKNSNSIFYTYQQLIQLRKENDWLVDADFELLPTAD--------KVFAYLRKV 482 Query: 634 DNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 E+ L++ N L + ++ L N N + KL + + K+ Sbjct: 483 REERYLIVVNVSDQEEVLEIDVDKQETLISN----TNESAALANHKLQPWDAFCIKI 535 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 58/171 (33%), Positives = 89/171 (52%), Gaps = 6/171 (3%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM-SYHG 113 YQ+ SF D++GDG GDL G+T KLDYL +LGV A+WLSP++ +G Sbjct: 3 KHWWHKATVYQIYPKSFMDTNGDGIGDLKGITSKLDYLQKLGVMAIWLSPVYDSPMDDNG 62 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD+ +Y + G +D D L+T+A RGIKI +D V+NHT H WF EA +S Sbjct: 63 YDIANYEAIADIFGNMADMDNLLTQAKMRGIKIIMDLVVNHTSDEHAWFIEAREHPDSSE 122 Query: 174 RNYYSFSEDP---KTDIAAGKIAMIT--QEGAAGYNAAEWFQVSDETAAVK 219 R+YY + + P ++ + + + + ++ E A ++ Sbjct: 123 RDYYIWCDQPNDLESIFGGSAWQYDDKSDQYYLHFFSKKQPDLNWENANLR 173 >5BRQ-A nrPDB Length = 568 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 103/478 (21%), Positives = 157/478 (32%), Gaps = 104/478 (21%) Query: 293 TSNASFWPSGTKYGASSSSEKLALNKDFKLTNAGNPANIM---------FDSQQITYF-H 342 TS W G + + KD K N P N F ++ Y+ H Sbjct: 113 TSTEHRWFKEAASGKENLYRDFYIWKDMK-PNGAPPTNWESKFGGSAWEFHAESGQYYLH 171 Query: 343 SHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEEN 402 + T ADLN+ + + + W +G+DG RLD + I + Sbjct: 172 LYDVTQ--ADLNWENEA------VRKKVYEMMHFWFEKGIDGFRLDVINVISKDQ----- 218 Query: 403 PRFLKMFYEDMNAYYKQKGHTDDFY--MIGEVLSEYDKVA-----------------PYY 443 RF D +Y +F M EV S+YD + P Sbjct: 219 -RFPDDDEGDGRRFYTDGPRVHEFLNEMNREVFSKYDSMTVGEMSSTTIADCIRYTNPES 277 Query: 444 KGLPALFEFSFWYRLEWGINNSTGCYF----AKDILSYQQKYANYRSDYIEATKLSNHDE 499 + L +F F F K ILS Q N + A NHD+ Sbjct: 278 RELDMVFNFHHLKADYPNGEKWALADFDFLKLKKILSEWQTEMNKGGGW-NALFWCNHDQ 336 Query: 500 DRTSSKLGKS----ADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNG----------- 544 R S+ G K+ A + G PYIY GEELG+ K + Sbjct: 337 PRIVSRYGDDGKYRKKSAKMLATAIHMLQGTPYIYQGEELGMTNPKFDDISLYRDVESLN 396 Query: 545 -----------------------DEYVRSPMLWGDSYTTNYTDK-TDATVSKNVKTVADQ 580 + R+P+ W +T V N K + + Sbjct: 397 MYRILKEAGKPEAEIIEILKAKSRDNSRTPVQWNGEENAGFTAGTPWIPVPDNYKEINAE 456 Query: 581 QA--DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKL 638 +A D S+ Y L LR + + G+ + + + A+ +EKL Sbjct: 457 EALNDPDSIFYHYKKLNELRKEFDIITTGDYQLILEDD-------QELYAYLRNGADEKL 509 Query: 639 LVIHNFGGTAMQLPLTDKI-----EKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 LVI+NF G + L D I + + ++ +T +T+K Y S+V+ L Sbjct: 510 LVINNFYGKETEFQLPDDIDIEGYDAKVLISNDTDLPESFKRFTVK--PYQSIVYHLA 565 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 52/126 (41%), Positives = 84/126 (66%), Gaps = 1/126 (0%) Query: 57 TKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM-SYHGYD 115 + + YQ+ SF D+ G+G GD+ G+ +KLDY+ +L +WL+PI+ + +GYD Sbjct: 14 WWKKAVVYQIYPKSFKDTTGNGVGDIRGIIEKLDYIKELACDVIWLTPIYQSPQNDNGYD 73 Query: 116 VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRN 175 ++DY ++ + GT +DF+ L+ EAH RGIK+ +D V+NHT T H WF EA+S E+ YR+ Sbjct: 74 ISDYYSIHEEYGTMADFEELLEEAHKRGIKVIMDLVVNHTSTEHRWFKEAASGKENLYRD 133 Query: 176 YYSFSE 181 +Y + + Sbjct: 134 FYIWKD 139 >5WCZ-A nrPDB Length = 586 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 84/432 (19%), Positives = 144/432 (33%), Gaps = 94/432 (21%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + +D Y+ +F + DLN+ + + D + W+ RGVDG R+D Sbjct: 172 SAWTYDEGTGQYYLHYF-SKKQPDLNWENEA------VRREVYDVMRFWMDRGVDGWRMD 224 Query: 389 AVKHIYHSETSEE----------------NPRFLKMFYEDMNAYYKQKGHTDDFYMIGEV 432 + I + N L F ++MN ++ D +GE Sbjct: 225 VIGSISKYTDFPDYETDHSRSYIVGRYHSNGPRLHEFIQEMN---REVLSHYDCMTVGEA 281 Query: 433 LSEYDKVAPYY-----KGLPALFEFSFWYRLEWGINNSTGCYFAK--DILSYQQKYANYR 485 + A Y + L +F F ++ N+ G + K D+++ ++ ++ Sbjct: 282 NGSDIEEAKKYTDASRQELNMIFTFEHM-DIDKEQNSPNGKWQIKPFDLIALKKTMTRWQ 340 Query: 486 SDY----IEATKLSNHDEDRTSSKLGKSADK----CKLAAAVLLTSAGHPYIYYGEELGL 537 + NHD+ R S+ G K A VL G P+IY GEE+G+ Sbjct: 341 TGLMNVGWNTLYFENHDQPRVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGM 400 Query: 538 YGTKDN-----------------------------------GDEYVRSPMLWGDSYTTNY 562 + G ++ R+PM W + Sbjct: 401 VNSDMPLEMYDDLEIKNAYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGF 460 Query: 563 TDK-TDATVSKNVK--TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQ 619 T V+ + V + D S+ Y L +LR Y + G+ + Sbjct: 461 TAGDPWIPVNSRYQDINVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDP-- 518 Query: 620 EKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLT----DKIEKVLFVNGETQQNTDSDS 675 + ++ EKLLV+ N + KVL N Q+ D S Sbjct: 519 -----QVFSYLREYRGEKLLVVVNLSEEKALFEAPPELIHERWKVLISN-YPQERADLKS 572 Query: 676 YTLKLGGYASVV 687 +LK Y +V+ Sbjct: 573 ISLK--PYEAVM 582 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 76/242 (31%), Positives = 123/242 (50%), Gaps = 24/242 (9%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM-SYHG 113 E + + YQ+ SF D++GDG+GDL GV QKLDY+ LG +WLSP+ +G Sbjct: 27 GEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGADVIWLSPVFDSPQDDNG 86 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD++DY + + GT D +L+ E H RG+KI +D V+NHT H WF E+ S ++PY Sbjct: 87 YDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNHTSDEHAWFAESRKSKDNPY 146 Query: 174 RNYYSFSEDPKTD----------IAAGKIAMITQEG--AAGYNAAEWFQVSDETAAVKG- 220 R+YY + +DPK D + G Y + + ++ E AV+ Sbjct: 147 RDYYLW-KDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYLHYFSKKQPDLNWENEAVRRE 205 Query: 221 ---LLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGEDICKKFYDKGNNIY 277 +++F +D + V+ + +K D PD TD+++ G +++ G ++ Sbjct: 206 VYDVMRFWMDRGVDGWRMDVIGSISKY-TDFPDYETDHSRSYIVG-----RYHSNGPRLH 259 Query: 278 EL 279 E Sbjct: 260 EF 261 >2ZE0-A nrPDB Length = 555 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 82/422 (19%), Positives = 138/422 (32%), Gaps = 79/422 (18%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + +D + Y+ H DLN+ S QA+ + W+ +G+DG R+D Sbjct: 147 SAWQYDERTGQYY-LHIFDVKQPDLNWE------NSEVRQALYEMVNWWLDKGIDGFRID 199 Query: 389 AVKHIYHSETSEE--NPRFLK------------MFYEDMNAYYKQKGHTDDFYMIGEVLS 434 A+ HI + NP+ LK E + +Q D +GE Sbjct: 200 AISHIKKKPGLPDLPNPKGLKYVPSFAGHMNQPGIMEYLRELKEQTFARYDIMTVGEANG 259 Query: 435 EYDKVAPYYKG-----LPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYI 489 A + G +F+F E + S K L+ QK R Sbjct: 260 VTVDEAEQWVGEENGVFNMIFQFEHLGLWERRADGSIDVRRLKRTLTKWQKGLENRG--W 317 Query: 490 EATKLSNHDEDRTSSKLGKSA----DKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN-- 543 A L NHD R+ S G + K A+ G P+IY G+E+G+ + + Sbjct: 318 NALFLENHDLPRSVSTWGNDRDYWAESAKALGALYFFMQGTPFIYQGQEIGMTNVRFDDI 377 Query: 544 --------------------------------GDEYVRSPMLWGDSYTTNYTDK-TDATV 570 G + R+PM W + +T V Sbjct: 378 RDYRDVSALRLYELERAKGRTHEEAMTIIWKTGRDNSRTPMQWSGASNAGFTTGTPWIKV 437 Query: 571 SKNVK--TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAA 628 ++N + V ++ D +S+ + Y + +LR G + S I A Sbjct: 438 NENYRTINVEAERRDPNSVWSFYRQMIQLRKANELFVYGTYDLLLENHPS-------IYA 490 Query: 629 WYMTKDNEKLLVIHNFGGTAMQLPLTDKI--EKVLFVNGETQQNTDSDSYTLKLGGYASV 686 + T ++ LV+ N L ++ ++ KL Y + Sbjct: 491 YTRTLGRDRALVVVNLSDRPSLYRYDGFRLQSSDLALSNYPV-RPHKNATRFKLKPYEAR 549 Query: 687 VF 688 V+ Sbjct: 550 VY 551 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 55/136 (40%), Positives = 85/136 (62%), Gaps = 1/136 (0%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-YHG 113 + ++YQ+ SF D++GDG GDL G+ +KLDYL +LGV +W+ PI+ + +G Sbjct: 3 KTWWKEGVAYQIYPRSFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNADNG 62 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD++DY + + GT DFD L+ +AH RG+K+ LD V+NHT HPWF E+ SS ++P Sbjct: 63 YDISDYYAIMDEFGTMDDFDELLAQAHRRGLKVILDLVINHTSDEHPWFIESRSSRDNPK 122 Query: 174 RNYYSFSEDPKTDIAA 189 R++Y + + Sbjct: 123 RDWYIWRDGKDGREPN 138 >5ZCD-A nrPDB Length = 555 Score = 245 bits (624), Expect = 7e-65, Method: Composition-based stats. Identities = 83/426 (19%), Positives = 144/426 (33%), Gaps = 80/426 (18%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + FD + Y+ H + DLN+ + + W+ +G+DG R+D Sbjct: 147 SAWEFDEKTKEYY-MHVFSKKQPDLNWENE------KVRHELYEMVNWWLDKGIDGFRVD 199 Query: 389 AVKHIYHSETSEENPRFLK-MFYEDMNAYYKQKGHTD-------------DFYMIGEVL- 433 A+ HI + P K + + + G + D +G+ Sbjct: 200 AISHIKKVAGFPDLPNPEKLDYVPSFEGHMNRPGIQEHLKELKEKTFAKYDIMTVGQANG 259 Query: 434 ----SEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYI 489 S + VA +F+F + G K IL+ Q + + Sbjct: 260 VTSDSADEWVAEDGGNFNMIFQFEHMGLWDKGEEKPLDLIELKTILTNWQNGLEKINGW- 318 Query: 490 EATKLSNHDEDRTSSKLGK---SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN--- 543 A L NHD+ R+ +K G + K AA+ G P+IY G+ELG+ K + Sbjct: 319 NALYLENHDQIRSVNKFGSTAYRVESAKCLAALYFLMKGTPFIYQGQELGMTNVKFDSID 378 Query: 544 -------------------------------GDEYVRSPMLWGDSYTTNYTDK-TDATVS 571 G + R+PM W ++ V+ Sbjct: 379 DYDDVGMINYYRIQREKGDSHDEIMKVIWETGRDNSRTPMQWNTEKNAGFSTGNPWMKVN 438 Query: 572 KNVK--TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAW 629 N V +Q++D +S+LN Y L ++R + L G ++ I A+ Sbjct: 439 PNYVDINVEEQKSDKNSVLNFYKQLIKIRKQHDVLVYGTYKLL-------AEEDSAIYAY 491 Query: 630 YMTKDNEKLLVIHNFGGTAMQLPLTDKIE----KVLFVNGETQQNTDSDSYTLKLGGYAS 685 T + + +VI N + +VL N +N + TL Y + Sbjct: 492 TRTLEGKTAVVICNMSPNNQTFEFPSESSFTNIEVLIHNYPLDKNETLEQCTLH--PYET 549 Query: 686 VVFKLG 691 V+ + Sbjct: 550 RVYLIS 555 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 57/136 (41%), Positives = 85/136 (62%), Gaps = 1/136 (0%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY-HG 113 + + ++YQ+ SF DS+GDG GD+ GV KLDYL+ LG+ +W+ PI+ + +G Sbjct: 3 KKWWKEAVAYQIYPRSFMDSNGDGIGDIQGVISKLDYLSDLGIDVIWICPIYQSPNDDNG 62 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD++DY + GT DFD L+ E H+RG+K+ +D V+NHT HPWF E+ S+ E+PY Sbjct: 63 YDISDYKDIMKDFGTMEDFDELLDEVHHRGMKLIMDLVINHTSDEHPWFLESRSAKENPY 122 Query: 174 RNYYSFSEDPKTDIAA 189 R+YY + E Sbjct: 123 RDYYIWHEGKDGKEPN 138 >3ZO9-A nrPDB Length = 593 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 88/426 (20%), Positives = 152/426 (35%), Gaps = 85/426 (19%) Query: 329 ANIMFDS-QQITYFHSHFCTDWFADLNYGPVDQAGESPAYQA-IADAAKGWIARGVDGLR 386 +N FD ++ Y+H F DLNY ++PA Q + D + W+ G+DG R Sbjct: 178 SNWTFDPVRRQFYWHRFFSHQ--PDLNY-------DNPAVQEAMLDVLRFWLDLGIDGFR 228 Query: 387 LDAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAP 441 LDAV +++ E + E FLK + ++ Y + + +++ Sbjct: 229 LDAVPYLFEREGTNCENLPETHAFLKRCRKAIDDEYPGRVLLAEA-------NQWPADVV 281 Query: 442 YYKGLP--------ALFEFSFWYRL--------------------------EWGINNSTG 467 Y G P F F R+ +WGI Sbjct: 282 AYFGDPDTGGDECHMAFHFPLMPRIFMAVRRESRFPISEILAQTPPIPDTAQWGIFLRNH 341 Query: 468 CYFAKDILSYQQK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSA 524 ++++ +++ YA Y D K + R + L ++ +L A+LL+ Sbjct: 342 DELTLEMVTDEERDYMYAEYAKD--PRMKANVGIRRRLAPLLENDRNQIELFTALLLSLP 399 Query: 525 GHPYIYYGEELGLYGTKDNGD-EYVRSPMLWGDSYTTNYTDKTD----------ATVSKN 573 G P +YYG+E+G+ GD + VR+PM W ++ T A + Sbjct: 400 GSPVLYYGDEIGMGDIIWLGDRDSVRTPMQWTPDRNAGFSKATPGRLYLPPNQDAVYGYH 459 Query: 574 VKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTK 633 V Q + SLLN ++ +R+ + A A G + N S I + Sbjct: 460 SVNVEAQLDSSSSLLNWTRNMLAVRSRHDAFAVGTFRELGGSNPSVLA---YIREVTRQQ 516 Query: 634 DN-----EKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSD----SYTLKLGGYA 684 + + +L ++N + L + T Y L L G+ Sbjct: 517 GDGGAKTDAVLCVNNLSRFPQPIELNLQQWAGYIPVEMTGYVEFPSIGQLPYLLTLPGHG 576 Query: 685 SVVFKL 690 F+L Sbjct: 577 FYWFQL 582 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 90/164 (54%), Gaps = 3/164 (1%) Query: 37 EPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLG 96 P E A T DT + + Y++L+ +F DS+ DG GDL G+T+KLDY+ LG Sbjct: 17 HPNAEDFGHARTLPTDT--NWFKHAVFYEVLVRAFYDSNADGIGDLRGLTEKLDYIKWLG 74 Query: 97 VKALWLSPIHPCM-SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 V LWL P + GYD+ D+ KV P+ GT DF L+ AH RGI+I D VMNHT Sbjct: 75 VDCLWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITDLVMNHT 134 Query: 156 GTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEG 199 H WF E+ + + PY ++Y +S+ A I + T+E Sbjct: 135 SDQHEWFQESRHNPDGPYGDFYVWSDTSDRYPDARIIFVDTEES 178 >5YKB-A nrPDB Length = 571 Score = 240 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 82/368 (22%), Positives = 128/368 (34%), Gaps = 64/368 (17%) Query: 329 ANIMFDSQQ-ITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRL 387 +N D Q Y+H F + DLNY + + AA+ W+ G+DG R+ Sbjct: 159 SNWTLDEQAGKYYWHRFFASQ--PDLNYD------NPKVVEELHGAARFWLDLGLDGFRV 210 Query: 388 DAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPY 442 DAV ++ E + E LK F ++ Y + + + E + EY Sbjct: 211 DAVPYLIEREGTSCENLPETHEILKGFRAMVDREYPGRLLLAEAFQWPEEVVEYFGTEAE 270 Query: 443 YKGLPALFEFSFWYRL--------------------------EWGINNSTGCYFAKDILS 476 + F F RL +W I ++++ Sbjct: 271 PE-FHMCFNFPVMPRLYMSLKREDTSSIREIMGRLPKIPSFGQWCIFLRNHDELTLEMVT 329 Query: 477 YQQK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGE 533 ++ YA Y D K++ R + L + +L VLL G P +YYG+ Sbjct: 330 DDERAFMYAAYAPDA--RMKINVGIRRRLAPLLDNDRRRIELLNTVLLALPGSPVLYYGD 387 Query: 534 ELGL-YGTKDNGDEYVRSPMLWGDSYTTNYTDKTD----------ATVSKNVKTVADQQA 582 E+G+ VR+PM W + ++ V Q Sbjct: 388 EIGMGDDLGLPDRNGVRTPMQWNAGTSGGFSTAQPSDCFFPPIQDPVYGFGRVNVQSQLQ 447 Query: 583 DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIH 642 D SLL LR +PA A G++T N + I A+ D E LL++ Sbjct: 448 DPSSLLKWTARQLELRRAHPAFAHGDLTFIETGNPA-------ILAFTRQYDGETLLIVS 500 Query: 643 NFGGTAMQ 650 NF G A Sbjct: 501 NFAGNAQA 508 Score = 181 bits (460), Expect = 7e-46, Method: Composition-based stats. Identities = 60/157 (38%), Positives = 82/157 (52%), Gaps = 11/157 (7%) Query: 48 TASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 A P+ + ++ + Y+L + +F D +GDG GD G+T +LDYL LGV LWL P P Sbjct: 5 QAHPEWY----KSAVFYELSVRTFQDGNGDGKGDFPGLTSRLDYLKNLGVDCLWLLPWFP 60 Query: 108 CM-SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEAS 166 GYDV DY ++P LGT DF + EAH RG+ + D V NHT + HPWF A Sbjct: 61 SPLRDDGYDVADYRGIHPDLGTLDDFKVFLREAHARGLWVIGDLVTNHTSSDHPWFQAAR 120 Query: 167 SSSESP------YRNYYSFSEDPKTDIAAGKIAMITQ 197 P Y +YY +S++ K I T+ Sbjct: 121 RGPTLPDGSPNEYHDYYVWSDEGKEYADTRIIFTDTE 157 >1SMA-A nrPDB Length = 588 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 79/355 (22%), Positives = 128/355 (36%), Gaps = 68/355 (19%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHSETSEENPRFL 406 D FA + + P + + D A WI +DG RLD I H +F Sbjct: 287 DTFAFVPHMPKLNTAHPEVKRYLLDVATYWIREFDIDGWRLDVANEIDH--------QFW 338 Query: 407 KMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNST 466 + F + + A D Y++GE+ + +P L F + + + ++ Sbjct: 339 REFRQAVKAL------KPDVYILGEIWHD---------AMPWLRGDQFDAVMNYPLADAA 383 Query: 467 GCYFAKDILSYQQ-------KYANYRSDYIEATK--LSNHDEDRTSSKLGKSADKCKLAA 517 +FAK+ +S + +Y EA L +HD R + G K KL Sbjct: 384 LRFFAKEDMSASEFADRLMHVLHSYPKQVNEAAFNLLGSHDTPRLLTVCGGDVRKVKLLF 443 Query: 518 AVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTV 577 LT G P IYYG+E+G+ G D R M+W Sbjct: 444 LFQLTFTGSPCIYYGDEIGMTGGNDP---ECRKCMVWDP--------------------- 479 Query: 578 ADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEK 637 + L L LR Y AL G++ + +E + T NE Sbjct: 480 ---EKQNKELYEHVKQLIALRKQYRALRRGDVAFLTADDEVNH------LVYAKTDGNET 530 Query: 638 LLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTL--KLGGYASVVFKL 690 +++I N A ++P+ VN T + +++ TL L Y V++ + Sbjct: 531 VMIIINRSNEAAEIPMPIDARGKWLVNLLTGERFAAEAETLCVSLPPYGFVLYAV 585 Score = 161 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 41/149 (27%), Positives = 65/149 (43%), Gaps = 20/149 (13%) Query: 55 DETKRADISYQLLLYSFADSDGDGY-------------------GDLNGVTQKLDYLNQL 95 + + + YQ+ FA+ + GDL G+ LDYL L Sbjct: 129 PDWVKDTVWYQIFPERFANGNPAISPKGARPWGSEDPTPTSFFGGDLQGIIDHLDYLADL 188 Query: 96 GVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 G+ ++L+PI S H YD DY +++P G + LV H +GI++ LD V NH Sbjct: 189 GITGIYLTPIFRAPSNHKYDTADYFEIDPHFGDKETLKTLVKRCHEKGIRVMLDAVFNHC 248 Query: 156 GTAHPWFTEASSSS-ESPYRNYYSFSEDP 183 G F + + S Y++++ E P Sbjct: 249 GYEFAPFQDVLKNGAASRYKDWFHIREFP 277 >5X7U-A nrPDB Length = 549 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 81/411 (19%), Positives = 138/411 (33%), Gaps = 68/411 (16%) Query: 329 ANIMFDSQQ-ITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRL 387 +N +D + Y+H F DLNY Q I D W+ GVDGLRL Sbjct: 150 SNWTWDQEAGKYYWHRFFSHQ--PDLNYD------NPKVQQEILDIVGYWLDMGVDGLRL 201 Query: 388 DAVKHIYHSE-TSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGL 446 DAV ++Y E T+ EN F + + + + + ++ E + V Y+ Sbjct: 202 DAVPYLYEREGTNCENLPETHEFLKKLRKFVDD--NWPNRMLLAEANQWPEDVVAYFGNG 259 Query: 447 P---ALFEFSFWYRL--------------------------EWGINNSTGCYFAKDILSY 477 + F R+ +W + ++++ Sbjct: 260 DECHMAYHFPIMPRMYMALRREDRHPITEILRRTPPIPETCQWALFLRNHDELTLEMVTD 319 Query: 478 QQK---YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEE 534 +++ Y Y D +L+ R + L S + +L +L T G P IYYG+E Sbjct: 320 EERDYMYHEYAKD--PRMRLNLGIRRRLAPLLDNSERRIQLMHLLLFTLPGTPIIYYGDE 377 Query: 535 LGLYGTKDNGD-EYVRSPMLWGDSYTTNYTDKTD----------ATVSKNVKTVADQQAD 583 +G+ GD + VR+PM W ++ + V Q+ Sbjct: 378 IGMGDNVYLGDRDGVRTPMQWSGDRNAGFSRANPQALYLPPIRDPVFTYEAVNVEAQEQV 437 Query: 584 THSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 SLLN ++R YP G++ N + + A+ + +L N Sbjct: 438 PTSLLNWMKRTIQIRKKYPVFGRGSIRFLQPSN-------RAVLAYIRQYQDTTILCACN 490 Query: 644 FGGTAMQLPLT-DKIEKVLFVNGETQQNTDSDS---YTLKLGGYASVVFKL 690 L + + V + Y L G + F+L Sbjct: 491 LSRFCQAAELDLSDFKGLYPVELYGKTVFPQIGELPYLLTFGPHVFYWFEL 541 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 58/146 (39%), Positives = 83/146 (56%), Gaps = 1/146 (0%) Query: 55 DETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM-SYHG 113 + I Y++ + F DS+ DG GD+ G+T KLDY+ LGV A+WL P + G Sbjct: 5 PTWYKDAIIYEVGVRCFFDSNNDGSGDIPGLTAKLDYIESLGVTAIWLLPFYASPLKDGG 64 Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 YD++DY ++P GT DF + EAH RGI++ + V+NHT H WF EA S+ SPY Sbjct: 65 YDISDYRSLHPDFGTIEDFKVFLDEAHRRGIRVITELVLNHTSDQHQWFREARSNPNSPY 124 Query: 174 RNYYSFSEDPKTDIAAGKIAMITQEG 199 R+YY +S+ A I + T+ Sbjct: 125 RDYYVWSDTDDKYKDARIIFIDTERS 150 >1M53-A nrPDB Length = 570 Score = 234 bits (597), Expect = 1e-61, Method: Composition-based stats. Identities = 90/430 (20%), Positives = 145/430 (33%), Gaps = 89/430 (20%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + D++ Y+ +F DLN+ + + + W+ +GV G+R D Sbjct: 161 SAWQKDAKSGQYYLHYFARQ-QPDLNWD------NPKVREDLYAMLRFWLDKGVSGMRFD 213 Query: 389 AVKHIYHSETSEE-NPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYD-KVAPYYKGL 446 V P K F E + + M +VLS YD A G+ Sbjct: 214 TVATYSKIPGFPNLTPEQQKNFAEQYTMGPNIHRYIQE--MNRKVLSRYDVATAGEIFGV 271 Query: 447 PAL------------FEFSFWYRL---------EWGINNSTGCYFAKDILSYQQKYANYR 485 P +F + L W + + F + I Y Sbjct: 272 PLDRSSQFFDRRRHELNMAFMFDLIRLDRDSNERWRHKSWSLSQFRQIISKMDVTVGKYG 331 Query: 486 SDYIEATKLSNHDEDRTSSKLGKSADKC-----KLAAAVLLTSAGHPYIYYGEELGLY-- 538 L NHD R S G + K A + LT P+IY G ELG+ Sbjct: 332 ---WNTFFLDNHDNPRAVSHFGDDRPQWREASAKALATITLTQRATPFIYQGSELGMTNY 388 Query: 539 ---------------------------------GTKDNGDEYVRSPMLWGDSYTTNYTD- 564 + + R+P W D+ +T Sbjct: 389 PFRQLNEFDDIEVKGFWQDYVQSGKVTATEFLDNVRLTSRDNSRTPFQWNDTLNAGFTRG 448 Query: 565 KTDATVSKNVKTVADQQADT--HSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKD 622 K ++ N + ++ +T S+LN Y + +LR+ PAL G + + + Sbjct: 449 KPWFHINPNYVEINAEREETREDSVLNYYKKMIQLRHHIPALVYGAYQDLNPQDNT---- 504 Query: 623 YKPIAAWYMTKDNEKLLVIHNFGGTAMQ--LPLTDKIEKVLFVNGETQQNTDSDSYTLKL 680 + A+ T NE+ LV+ NF ++ LP D IE+V+ QQ S +L L Sbjct: 505 ---VYAYTRTLGNERYLVVVNFKEYPVRYTLPANDAIEEVVI--DTQQQAAAPHSTSLSL 559 Query: 681 GGYASVVFKL 690 + + V+KL Sbjct: 560 SPWQAGVYKL 569 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 50/143 (34%), Positives = 83/143 (58%), Gaps = 5/143 (3%) Query: 48 TASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 + P W + + YQ+ SF D++ DG GD+ G+ +KLDYL LG+ A+W++P + Sbjct: 14 SEYPAWW----KEAVFYQIYPRSFKDTNDDGIGDIRGIIEKLDYLKSLGIDAIWINPHYD 69 Query: 108 CMS-YHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEAS 166 + +GYD+++Y ++ + GT DFD LV E R +++ +D V+NHT HPWF ++ Sbjct: 70 SPNTDNGYDISNYRQIMKEYGTMEDFDSLVAEMKKRNMRLMIDVVINHTSDQHPWFIQSK 129 Query: 167 SSSESPYRNYYSFSEDPKTDIAA 189 S +PYR+YY + + Sbjct: 130 SDKNNPYRDYYFWRDGKDNQPPN 152 >1J0H-A nrPDB Length = 588 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 131/377 (34%), Gaps = 77/377 (20%) Query: 335 SQQITYFHSHFC---------TDWFADLNYGPVDQAGESPAYQAIADAAKGWI-ARGVDG 384 S+ +FH H D FA + P + + D A WI +DG Sbjct: 265 SKYKDWFHIHEFPLQTEPRPNYDTFAFVPQMPKLNTANPEVKRYLLDVATYWIREFDIDG 324 Query: 385 LRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYK 444 RLD I H F + F +++ A D Y++GE+ + Sbjct: 325 WRLDVANEIDH--------EFWREFRQEVKAL------KPDVYILGEIWHD--------- 361 Query: 445 GLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQ-------KYANYRSDYIEATK--LS 495 +P L F + + + +FAK+ +S +Q +Y ++ EA L Sbjct: 362 AMPWLRGDQFDAVMNYPFTDGVLRFFAKEEISARQFANQMMHVLHSYPNNVNEAAFNLLG 421 Query: 496 NHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWG 555 +HD R + G K KL LT G P IYYG+E+G+ G D R M+W Sbjct: 422 SHDTSRILTVCGGDIRKVKLLFLFQLTFTGSPCIYYGDEIGMTGGNDP---ECRKCMVWD 478 Query: 556 DSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVY 615 L L LR Y +L G ++ Sbjct: 479 PM------------------------QQNKELHQHVKQLIALRKQYRSLRRGEISFLHAD 514 Query: 616 NESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDS 675 +E YK T +E +LVI N +P+ VN T + +++ Sbjct: 515 DEMNYLIYK------KTDGDETVLVIINRSDQKADIPIPLDARGTWLVNLLTGERFAAEA 568 Query: 676 YTL--KLGGYASVVFKL 690 TL L Y V++ + Sbjct: 569 ETLCTSLPPYGFVLYAI 585 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 42/149 (28%), Positives = 66/149 (44%), Gaps = 20/149 (13%) Query: 55 DETKRADISYQLLLYSFADSDGDGY-------------------GDLNGVTQKLDYLNQL 95 + + + YQ+ FA+ + GDL G+ LDYL L Sbjct: 129 PDWVKDTVWYQIFPERFANGNPSISPEGSRPWGSEDPTPTSFFGGDLQGIIDHLDYLVDL 188 Query: 96 GVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 G+ ++L+PI S H YD DY +V+P G + L+ H +GI++ LD V NH Sbjct: 189 GITGIYLTPIFRSPSNHKYDTADYFEVDPHFGDKETLKTLIDRCHEKGIRVMLDAVFNHC 248 Query: 156 GTAHPWFTEASSSSE-SPYRNYYSFSEDP 183 G F + + E S Y++++ E P Sbjct: 249 GYEFAPFQDVWKNGESSKYKDWFHIHEFP 277 >4GI8-A nrPDB Length = 557 Score = 223 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 80/426 (18%), Positives = 135/426 (31%), Gaps = 81/426 (19%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 + D Y+ + DLN+ + + + W+ +GV G+R D Sbjct: 148 SAWEKDPVTGQYYLHYLGRQ-QPDLNWD------TPKLREELYAMLRFWLDKGVSGMRFD 200 Query: 389 AVKHIYHSETSEE-NPRFLKMFY------EDMNAYYKQKGHT----DDFYMIGEVLSEYD 437 V + + P +K F +++ Y ++ D GE+ Sbjct: 201 TVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHEKVFDHYDAVTAGEIFGAPL 260 Query: 438 KVAPYY-----KGLPALFEFSFW----YRLEWGINNSTGCYFAKDILSYQQKYANYRSDY 488 P + K L F F W T F + I Y Sbjct: 261 NQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYG--- 317 Query: 489 IEATKLSNHDEDRTSSKLGKSADKC-----KLAAAVLLTSAGHPYIYYGEELGL------ 537 L NHD R S G + K A V LT G P+I+ G+ELG+ Sbjct: 318 WNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTPFIFQGDELGMTNYPFK 377 Query: 538 -----------------------------YGTKDNGDEYVRSPMLWGDSYTTNYTD-KTD 567 + R+P W DS +T K Sbjct: 378 TLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPW 437 Query: 568 ATVSKNVKTVADQQA--DTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKP 625 V+ N + + D S+ + Y +L +R+ PAL+ G+ N Sbjct: 438 LKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSYRDIDPSNAD------- 490 Query: 626 IAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIE-KVLFVNGETQQNTDSDSYTLKLGGYA 684 + A+ ++D E LV+ NF L D + + + + + +L+L + Sbjct: 491 VYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQ 550 Query: 685 SVVFKL 690 S ++K+ Sbjct: 551 SGIYKV 556 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 55/159 (34%), Positives = 91/159 (57%), Gaps = 7/159 (4%) Query: 57 TKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-YHGYD 115 ++ + YQ+ SF D++GDG GD G+T+KLDYL LG+ A+W++P + + +GYD Sbjct: 6 WWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYD 65 Query: 116 VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRN 175 ++DY +V + GT DFDRL+ E RG+++ +D V+NH+ H WF + +S ++PYR+ Sbjct: 66 ISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDNPYRD 125 Query: 176 YYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDE 214 YY + + G +A E V+ + Sbjct: 126 YYFWRDGKDGHEPN------NYPSFFGGSAWEKDPVTGQ 158 >4CGT-A nrPDB Length = 678 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 87/362 (24%), Positives = 138/362 (38%), Gaps = 51/362 (14%) Query: 340 YFHSHFCTDWFADLN------YGPVDQAGESPAY-QAIADAAKGWIARGVDGLRLDAVKH 392 YFH + +D+ + N Y D + + DA K W+ GVDG+R+DAVKH Sbjct: 168 YFHHNGGSDFSSLENGIYKNLYDLADFNHNNATIDKYFKDAIKLWLDMGVDGIRVDAVKH 227 Query: 393 IYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEF 452 + + K + + A+ + + +G S+ D K +L +F Sbjct: 228 MPLG--------WQKSWMSSIYAHKPVFTFGE--WFLGSAASDADNTDFANKSGMSLLDF 277 Query: 453 SFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADK 512 F + ++T +A D + +Y + T + NHD DR + + + Sbjct: 278 RFNSAVRNVFRDNTSNMYALDSM-INSTATDYNQVNDQVTFIDNHDMDRFKTSAVNN-RR 335 Query: 513 CKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSK 572 + A A LTS G P IYYG E L G NGD R+ M TT + Sbjct: 336 LEQALAFTLTSRGVPAIYYGTEQYLTG---NGDPDNRAKMPSFSKSTTAF---------- 382 Query: 573 NVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMT 632 N+ L LR + PA+A G+ + + N+ + K + + Sbjct: 383 ----------------NVISKLAPLRKSNPAIAYGSTQQRWINNDVYVYERKFGKSVAVV 426 Query: 633 KDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFK 689 N L + G + LP TD + VL N T N +++TL G A + Sbjct: 427 AVNRNLSTSASITGLSTSLPTGSYTDVLGGVLNGNNITSTNGSINNFTLAAGATAVWQYT 486 Query: 690 LG 691 Sbjct: 487 TA 488 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 102/305 (33%), Gaps = 69/305 (22%) Query: 50 SPDTWDETKRA---DISYQLLLYSFADSDGDGY------------------GDLNGVTQK 88 PDT K++ D+ YQ+ F D + GD G+ K Sbjct: 1 DPDTAVTNKQSFSTDVIYQVFTDRFLDGNPSNNPTGAAYDATCSNLKLYCGGDWQGLINK 60 Query: 89 LD--YLNQLGVKALWLS-PIHPC-----------MSYHGYDVTDYTKVNPQLGTESDFDR 134 ++ Y + LGV ALW+S P+ +YHGY D+ K NP GT +DF Sbjct: 61 INDNYFSDLGVTALWISQPVENIFATINYSGVTNTAYHGYWARDFKKTNPYFGTMADFQN 120 Query: 135 LVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS------ESPYRNYYSFSEDPKTDIA 188 L+T AH +GIKI +D+ NHT A + + Y+ + Sbjct: 121 LITTAHAKGIKIVIDFAPNHTSPADAENGRLYDNGTLVGGYTNDTNGYFHHNGGSDFSSL 180 Query: 189 AGKIAMITQEGAAGYNAAE-------------WFQVSDETAAVKGLLKFTLDWSN----- 230 I A +N W + + V + L W Sbjct: 181 ENGI-YKNLYDLADFNHNNATIDKYFKDAIKLWLDMGVDGIRVDAVKHMPLGWQKSWMSS 239 Query: 231 --APSPILVVST----GTKADEDNPDTGTDNAKYLY---YGEDICKKFYDKGNNIYELTV 281 A P+ +D DN D + L + + F D +N+Y L Sbjct: 240 IYAHKPVFTFGEWFLGSAASDADNTDFANKSGMSLLDFRFNSAVRNVFRDNTSNMYALDS 299 Query: 282 DFEST 286 ST Sbjct: 300 MINST 304 >1V3M-A nrPDB Length = 686 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 106/454 (23%), Positives = 175/454 (38%), Gaps = 75/454 (16%) Query: 251 TGTDNAKYL-YYGEDICKKFYDKGNNIYELTVDFESTWGLLIRTSNA-------SFWPSG 302 +G +N Y Y+ D + K N Y DF++ LI T++A F P+ Sbjct: 90 SGVNNTAYHGYWARD-----FKKTNPAYGTMQDFKN----LIDTAHAHNIKVIIDFAPNH 140 Query: 303 TKYGASSSSEKLALNKDFKLTNAGNP-ANIMFDSQQITYFHSHFCTDWFADLN------Y 355 T + +SS+ + ++ +L + GN D+Q + FH + TD+ N Y Sbjct: 141 T---SPASSDDPSFAENGRLYDNGNLLGGYTNDTQNL--FHHYGGTDFSTIENGIYKNLY 195 Query: 356 GPVDQAGESPAYQ-AIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMN 414 D + + + DA K W+ GVDG+R+DAVKH+ + K F +N Sbjct: 196 DLADLNHNNSSVDVYLKDAIKMWLDLGVDGIRVDAVKHMPFG--------WQKSFMATIN 247 Query: 415 AYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDI 474 Y + F + E+ EY + A +L ++ F + ++T + Sbjct: 248 NYKPVFTFGEWFLGVNEISPEYHQFANE--SGMSLLDYRFAQKARQVFRDNTDNMYGLKA 305 Query: 475 LSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEE 534 + + +Y + T + NHD +R + G K + A A LTS G P IYYG E Sbjct: 306 M-LEGSEVDYAQVNDQVTFIDNHDMERFHTSNG-DRRKLEQALAFTLTSRGVPAIYYGSE 363 Query: 535 LGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSL 594 + G D D R P +++ T A + L Sbjct: 364 QYMSGGNDP-DNRARLP---------SFSTTTTA-------------------YQVIQKL 394 Query: 595 TRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLP-- 652 LR + PA+A G+ + + N+ + K + N + + G LP Sbjct: 395 APLRKSNPAIAYGSTHERWINNDVIIYERKFGNNVAVVAINRNMNTPASITGLVTSLPRG 454 Query: 653 -LTDKIEKVLFVNGET-QQNTDSDSYTLKLGGYA 684 D + +L N T + ++TL GG A Sbjct: 455 SYNDVLGGILNGNTLTVGAGGAASNFTLAPGGTA 488 Score = 125 bits (314), Expect = 6e-29, Method: Composition-based stats. Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 38/160 (23%) Query: 50 SPDTWDETKR---ADISYQLLLYSFADSDGDGY------------------GDLNGVTQK 88 +PDT K+ D+ YQ+ F+D + GD G+ K Sbjct: 1 APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGSCTNLRLYCGGDWQGIINK 60 Query: 89 LD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNPQLGTESDFDR 134 ++ YL +G+ A+W+S P+ S YHGY D+ K NP GT DF Sbjct: 61 INDGYLTGMGITAIWISQPVENIYSVINYSGVNNTAYHGYWARDFKKTNPAYGTMQDFKN 120 Query: 135 LVTEAHNRGIKIYLDYVMNHTGT---AHPWFTEASSSSES 171 L+ AH IK+ +D+ NHT P F E ++ Sbjct: 121 LIDTAHAHNIKVIIDFAPNHTSPASSDDPSFAENGRLYDN 160 >1A47-A nrPDB Length = 683 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 87/359 (24%), Positives = 134/359 (37%), Gaps = 65/359 (18%) Query: 340 YFHSHFCTDW-------------FADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 YFH + TD+ ADLN + A K W+ G+DG+R Sbjct: 175 YFHHYGGTDFSSYEDGIYRNLFDLADLNQQNSTIDS------YLKSAIKVWLDMGIDGIR 228 Query: 387 LDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGL 446 LDAVKH+ + K F + + +Y + F E+ + + + Sbjct: 229 LDAVKHMPFG--------WQKNFMDSILSYRPVFTFGEWFLGTNEI--DVNNTYFANESG 278 Query: 447 PALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKL 506 +L +F F ++ ++T + D + Q ++Y T + NHD DR + Sbjct: 279 MSLLDFRFSQKVRQVFRDNTDTMYGLDSM-IQSTASDYNFINDMVTFIDNHDMDRFYN-- 335 Query: 507 GKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKT 566 G S + A A LTS G P IYYG E + G NGD Y R+ M ++ TT Y Sbjct: 336 GGSTRPVEQALAFTLTSRGVPAIYYGTEQYMTG---NGDPYNRAMMTSFNTSTTAY---- 388 Query: 567 DATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPI 626 N+ L LR + PA+A G + + N+ + K Sbjct: 389 ----------------------NVIKKLAPLRKSNPAIAYGTTQQRWINNDVYIYERKFG 426 Query: 627 AAWYMTKDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGET-QQNTDSDSYTLKLG 681 + N L +N G LP TD + +L N + + +TL G Sbjct: 427 NNVALVAINRNLSTSYNITGLYTALPAGTYTDVLGGLLNGNSISVASDGSVTPFTLSAG 485 Score = 112 bits (281), Expect = 4e-25, Method: Composition-based stats. Identities = 38/137 (27%), Positives = 57/137 (41%), Gaps = 33/137 (24%) Query: 55 DETKRADISYQLLLYSFADSDGDGY------------------GDLNGVTQKLD--YLNQ 94 D+ YQ++ F D + GD G+ K++ YL Sbjct: 9 VVNYSTDVIYQIVTDRFVDGNTSNNPTGDLYDPTHTSLKKYFGGDWQGIINKINDGYLTG 68 Query: 95 LGVKALWLS-PIHP------------CMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHN 141 +GV A+W+S P+ SYHGY D+ + NP G+ +DF L+ AH Sbjct: 69 MGVTAIWISQPVENIYAVLPDSTFGGSTSYHGYWARDFKRTNPYFGSFTDFQNLINTAHA 128 Query: 142 RGIKIYLDYVMNHTGTA 158 IK+ +D+ NHT A Sbjct: 129 HNIKVIIDFAPNHTSPA 145 >1EO7-A nrPDB Length = 686 Score = 211 bits (538), Expect = 7e-55, Method: Composition-based stats. Identities = 104/461 (22%), Positives = 173/461 (37%), Gaps = 75/461 (16%) Query: 251 TGTDNAKYL-YYGEDICKKFYDKGNNIYELTVDFESTWGLLIRTSNAS-------FWPSG 302 +G +N Y Y+ D + K N Y DF++ LI ++A F P+ Sbjct: 90 SGVNNTAYHGYWARD-----FKKTNPAYGTIADFQN----LIAAAHAKNIKVIIDFAPNH 140 Query: 303 TKYGASSSSEKLALNKDFKLTNAGNP-ANIMFDSQQITYFHSHFCTDWFADLN------Y 355 T + +SS++ + ++ +L + G D+Q + FH + TD+ N Y Sbjct: 141 T---SPASSDQPSFAENGRLYDNGTLLGGYTNDTQNL--FHHNGGTDFSTTENGIYKNLY 195 Query: 356 GPVDQAGESPAYQ-AIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMN 414 D + + DA K W+ G+DG+R+ AVKH+ + K F +N Sbjct: 196 DLADLNHNNSTVDVYLKDAIKMWLDLGIDGIRMAAVKHMPFG--------WQKSFMAAVN 247 Query: 415 AYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDI 474 Y F + EV E K A +L +F F ++ ++T + Sbjct: 248 NYKPVFTFGAWFLGVNEVSPENHKFANE--SGMSLLDFRFAQKVRQVFRDNTDNMYGLKA 305 Query: 475 LSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEE 534 + + A+Y + T + NHD +R + K + A A LTS G P IYYG E Sbjct: 306 M-LEGSAADYAQVDDQVTFIDNHDMERFHASNAN-RRKLEQALAFTLTSRGVPAIYYGTE 363 Query: 535 LGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSL 594 + G D D R P +++ T A + L Sbjct: 364 QYMSGGTDP-DNRARIP---------SFSTSTTA-------------------YQVIQKL 394 Query: 595 TRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLP-- 652 LR + PA+A G+ + + N+ + K + + N L + G LP Sbjct: 395 APLRKSNPAIAYGSTQERWINNDVLIYERKFGSNVAVVAVNRNLNAPASISGLVTSLPQG 454 Query: 653 -LTDKIEKVLFVNGET-QQNTDSDSYTLKLGGYASVVFKLG 691 D + +L N + + ++TL GG A + Sbjct: 455 SYNDVLGGLLNGNTLSVGSGGAASNFTLAAGGTAVWQYTAA 495 Score = 125 bits (314), Expect = 6e-29, Method: Composition-based stats. Identities = 48/160 (30%), Positives = 70/160 (43%), Gaps = 38/160 (23%) Query: 50 SPDTWDETKR---ADISYQLLLYSFADSDG---------DGY---------GDLNGVTQK 88 +PDT K+ D+ YQ+ F+D + DG GD G+ K Sbjct: 1 APDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGTCTNLRLYCGGDWQGIINK 60 Query: 89 LD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNPQLGTESDFDR 134 ++ YL +GV A+W+S P+ S YHGY D+ K NP GT +DF Sbjct: 61 INDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGYWARDFKKTNPAYGTIADFQN 120 Query: 135 LVTEAHNRGIKIYLDYVMNHTGT---AHPWFTEASSSSES 171 L+ AH + IK+ +D+ NHT P F E ++ Sbjct: 121 LIAAAHAKNIKVIIDFAPNHTSPASSDQPSFAENGRLYDN 160 >1CYG-A nrPDB Length = 680 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 84/359 (23%), Positives = 133/359 (37%), Gaps = 64/359 (17%) Query: 340 YFHSHFCTDW-------------FADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 YFH + T + ADLN+ + + DA K WI G+DG+R Sbjct: 170 YFHHNGGTTFSSLEDGIYRNLFDLADLNH------QNPVIDRYLKDAVKMWIDMGIDGIR 223 Query: 387 LDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGL 446 +DAVKH+ + K ++++ Y + F EV + A Sbjct: 224 MDAVKHMPFG--------WQKSLMDEIDNYRPVFTFGEWFLSENEVDANNHYFANE--SG 273 Query: 447 PALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKL 506 +L +F F +L + N++ ++ + + Q + Y + T + NHD DR Sbjct: 274 MSLLDFRFGQKLRQVLRNNSDNWYGFNQM-IQDTASAYDEVLDQVTFIDNHDMDRFMID- 331 Query: 507 GKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKT 566 G K +A AVLLTS G P IYYG E + G NGD R M + T Y Sbjct: 332 GGDPRKVDMALAVLLTSRGVPNIYYGTEQYMTG---NGDPNNRKMMSSFNKNTRAYQ--- 385 Query: 567 DATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPI 626 + L+ LR PALA G+ + + + + + Sbjct: 386 -----------------------VIQKLSSLRRNNPALAYGDTEQRWINGDVYVYERQFG 422 Query: 627 AAWYMTKDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGET-QQNTDSDSYTLKLG 681 + N ++ G LP TD++ +L N N +++ L G Sbjct: 423 KDVVLVAVNRSSSSNYSITGLFTALPAGTYTDQLGGLLDGNTIQVGSNGSVNAFDLGPG 481 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 44/130 (33%), Positives = 62/130 (47%), Gaps = 31/130 (23%) Query: 60 ADISYQLLLYSFADSDGDGY------------------GDLNGVTQKLD--YLNQLGVKA 99 +D+ YQ+++ F D + GD G+ K++ YL +GV A Sbjct: 11 SDVVYQIVVDRFVDGNTSNNPSGALFSSGCTNLRKYCGGDWQGIINKINDGYLTDMGVTA 70 Query: 100 LWLS-PIHP----------CMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL 148 +W+S P+ SYHGY D+ K NP GT SDF RLV AH +GIK+ + Sbjct: 71 IWISQPVENVFSVMNDASGSASYHGYWARDFKKPNPFFGTLSDFQRLVDAAHAKGIKVII 130 Query: 149 DYVMNHTGTA 158 D+ NHT A Sbjct: 131 DFAPNHTSPA 140 >1EA9-C nrPDB Length = 583 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 117/347 (33%), Gaps = 56/347 (16%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFL 406 D FA P + + AA+ WI G+DG RLD + H +F Sbjct: 284 DTFAFEPLMPKLNTEHPDVKEYLLKAAEYWIRETGIDGWRLDVANEVSH--------QFW 335 Query: 407 KMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNST 466 + F + K D Y++GEV E + A+ + F + + Sbjct: 336 REFRRVV------KQANPDAYILGEVWHES-SIWLEGDQFDAVMNYPFTNAVLDFFIHQI 388 Query: 467 GCYFAKDILSYQQKYANYRSDYIEATK--LSNHDEDRTSSKLGKSADKCKLAAAVLLTSA 524 + ++ A Y E L +HD R ++ K KLA T Sbjct: 389 ADAEKFSFM-LGKQLAGYPRQASEVMFNLLDSHDTARLLTQADGDKRKMKLAVLFQFTYF 447 Query: 525 GHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADT 584 G P IYYG+E+GL G D G R M W ++ Sbjct: 448 GTPCIYYGDEVGLDGGHDPG---CRKCMEWDETKH------------------------D 480 Query: 585 HSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN- 643 L Y ++ RLR + AL G + S++ A+ D + +LV+ N Sbjct: 481 KDLFAFYQTVIRLRQAHAALRTGTFKFLTAEKNSRQ------IAYLREDDQDTILVVMNN 534 Query: 644 -FGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFK 689 G + LP+ L+ + T+KL Y V K Sbjct: 535 DKAGHTLTLPVRHAQWTHLWQDDVLT--AAHGQLTVKLPAYGFAVLK 579 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 26/192 (13%) Query: 29 ITDPAPEPEPPVEGQW--TALTASPDTWDETKRADISYQLLLYSFADSDGDG-------- 78 +T+P P+ E + P W + I YQ+ FA+ D Sbjct: 100 LTEPPANPDRLFEYPFINPVDVFQPPAWV---KDAIFYQIFPERFANGDTRNDPEGTLPW 156 Query: 79 -----------YGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLG 127 GDL GV LD+L++LGV A++ +P+ + H YD DY +++PQ G Sbjct: 157 GSADPTPSCFFGGDLQGVIDHLDHLSKLGVNAVYFTPLFKATTNHKYDTEDYFQIDPQFG 216 Query: 128 TESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDPKTD 186 + +LV H RGI++ LD V NH+G P F + + E S Y++++ P + Sbjct: 217 DKDTLKKLVDLCHERGIRVLLDAVFNHSGRTFPPFVDVLKNGEKSKYKDWFHIRSLP-LE 275 Query: 187 IAAGKIAMITQE 198 + G T Sbjct: 276 VVDGIPTYDTFA 287 >1JL8-A nrPDB Length = 585 Score = 191 bits (486), Expect = 7e-49, Method: Composition-based stats. Identities = 66/348 (18%), Positives = 118/348 (33%), Gaps = 68/348 (19%) Query: 353 LNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 + P + + + D A+ W+ +G+DG RL+ + H+ F + F Sbjct: 290 VPAMPKLRTENPEVKEYLFDVARFWMEQGIDGWRLNVANEVDHA--------FWREFR-- 339 Query: 413 MNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAK 472 K D ++GE+ + L F + + S +FA Sbjct: 340 ----RLVKSLNPDALIVGEIWHD---------ASGWLMGDQFDSVMNYLFRESVIRFFAT 386 Query: 473 DIL---SYQQKYANYRSDYIEA------TKLSNHDEDRTSSKLGKSADKCKLAAAVLLTS 523 + + + R Y E L +HD +R + G + K +LA +T Sbjct: 387 GEIHAERFDAELTRARMLYPEQAAQGLWNLLDSHDTERFLTSCGGNEAKFRLAVLFQMTY 446 Query: 524 AGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQAD 583 G P IYYG+E+G+ G D R PM+W +++ Sbjct: 447 LGTPLIYYGDEIGMAGATDPD---CRRPMIW------------------------EEKEQ 479 Query: 584 THSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 L Y L RLR+ +L GN+ ++ + A+ T ++ + V+ N Sbjct: 480 NRGLFEFYKELIRLRHRLASLTRGNVRSWHADKQAN------LYAFVRTVQDQHVGVVLN 533 Query: 644 FGGTAMQ--LPLTDKIEKVLFVNGETQQN-TDSDSYTLKLGGYASVVF 688 G L + + K ++ L L Y ++ Sbjct: 534 NRGEKQTVLLQVPESGGKTWLDCLTGEEVHGKQGQLKLTLRPYQGMIL 581 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 56/177 (31%), Positives = 77/177 (43%), Gaps = 21/177 (11%) Query: 33 APEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDG-------------- 78 A + V + T E + + YQ+ FA+ D Sbjct: 103 AERSKAGVFQYAYIHRSEVFTTPEWAKEAVIYQIFPERFANGDPSNDPPGTEQWAKDARP 162 Query: 79 ------YGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDF 132 GDL GV +L YL +LGV AL+ +PI S+H YD DY ++PQ G F Sbjct: 163 RHDSFYGGDLKGVIDRLPYLEELGVTALYFTPIFASPSHHKYDTADYLAIDPQFGDLPTF 222 Query: 133 DRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSE-SPYRNYYSFSEDPKTDIA 188 RLV EAH RGIKI LD V NH G F + E S Y++++ + P + + Sbjct: 223 RRLVDEAHRRGIKIILDAVFNHAGDQFFAFRDVLQKGEQSRYKDWFFIEDFPVSKTS 279 >3AXH-A nrPDB Length = 589 Score = 188 bits (476), Expect = 9e-48, Method: Composition-based stats. Identities = 55/148 (37%), Positives = 83/148 (56%), Gaps = 2/148 (1%) Query: 45 TALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSP 104 T +A P+T + + YQ+ SF DS+ DG+GD+ G+ KL+Y+ +LG A+W+SP Sbjct: 2 TISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISP 61 Query: 105 IHPCM-SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFT 163 + GYD+ +Y KV P GT D L+ + H G+K D V+NH + H WF Sbjct: 62 FYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFK 121 Query: 164 EASSSSESPYRNYYSFSEDPKTDIAAGK 191 E+ SS +P R+++ + PK A GK Sbjct: 122 ESRSSKTNPKRDWFFWRP-PKGYDAEGK 148 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 79/441 (17%), Positives = 145/441 (32%), Gaps = 97/441 (21%) Query: 329 ANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIAD-AAKGWIARGVDGLRL 387 + FD + ++ FC+ DLN+ D +AI + A W+ GVDG R+ Sbjct: 162 SAWTFDEKTQEFYLRLFCS-TQPDLNWENEDC------RKAIYESAVGYWLDHGVDGFRI 214 Query: 388 DA------------VKHIYHSETSEE------NPRFLKMFYEDMNAYYKQKGH-TDDFYM 428 D + + T + N + F+++MN + + + + Sbjct: 215 DVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMT 274 Query: 429 IGEVLSEYDKVAPYY-----KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQ-QKYA 482 +G + D+ Y L LF FS + F + Sbjct: 275 VGAMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELF 334 Query: 483 NY--RSDYIEATKLSNHDEDRTSSKLGKSADK-----CKLAAAVLLTSAGHPYIYYGEEL 535 Y +D L NHD+ R+ ++ G + K KL + +L G Y+Y G+EL Sbjct: 335 RYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQEL 394 Query: 536 G--------------------------------------LYGTKDNGDEYVRSPMLWG-D 556 G L ++ R+PM W + Sbjct: 395 GQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSRE 454 Query: 557 SYTTNYTD---KTDATVSKNVK---TVADQQADTHSLLNIYFSLTRLRNTY-PALAEG-N 608 ++ K ++ + + V D+ D +S+LN + + R + G + Sbjct: 455 EPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYD 514 Query: 609 MTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLT-DKIEKVLFVNGET 667 + N K + ++ +N+ L NF A + D L Sbjct: 515 FEFIDLDN-------KKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYP 567 Query: 668 QQNTDSDSYTLKLGGYASVVF 688 ++ D+ S TLK + ++ Sbjct: 568 KKEVDASSRTLK--PWEGRIY 586 >2WC7-A nrPDB Length = 488 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 75/345 (21%), Positives = 126/345 (36%), Gaps = 70/345 (20%) Query: 357 PVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAY 416 P + I + A+ W+ G+DG RLD I + P F + F + Sbjct: 179 PEFNHDNPEVREYIMEIAEYWLKFGIDGWRLDVPFEI-------KTPGFWQEFRD----- 226 Query: 417 YKQKGHTDDFYMIGEVLSE---------YDKVAPYYKGLPAL-FEFSFWYRLEWGINNST 466 + K + Y++GEV + +D V Y P + F LE + Sbjct: 227 -RTKAINPEAYIVGEVWGDSRQWLDGTQFDGVMNYLFAGPTIAFAAGDRVVLEQVQSRDY 285 Query: 467 GCY---FAKDILSYQQKYANYRSDYIEATKLS---NHDEDRTSSKLGKSADKCKLAAAVL 520 Y FA + + Q+ I+ T+L+ +HD R + G +L+ +L Sbjct: 286 QPYPPLFAAEYATKIQEVLQLYPWEIQLTQLNLLASHDTARLMTIAGGDIASVELSTLLL 345 Query: 521 LTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQ 580 LT G P IYYG+E+GL G D D+ ++ +Q Sbjct: 346 LTFPGAPSIYYGDEVGLPGGIDP-----------------------DSRRGFPLEANWNQ 382 Query: 581 QADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLV 640 + + N + L +R TYPAL G+ + + T E+L++ Sbjct: 383 E-----IFNTHRQLITIRQTYPALRTGDYQVL--------YAQGQLYLFARTLGTEELII 429 Query: 641 IHNFGGTAMQ-----LPLTDKIEKVLFVNGETQQNTDSDSYTLKL 680 N G ++ L + K+L+ E + N + + L L Sbjct: 430 AINAGTSSATANVDVASLHTQPNKLLYGTAEAEWNGEEGTQQLSL 474 Score = 154 bits (388), Expect = 2e-37, Method: Composition-based stats. Identities = 49/182 (26%), Positives = 73/182 (40%), Gaps = 25/182 (13%) Query: 55 DETKRADISYQLLLYSFADS----------------------DGDGYGDLNGVTQKLDYL 92 + + + YQ+ FA S G GDL G+ + LDY+ Sbjct: 6 PDWVKHAVFYQIFPDRFARSKQPRKRLLQEARWEDWDSMPTLQGYKGGDLWGIMEDLDYI 65 Query: 93 NQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVM 152 LG+ A++ +PI S H Y DY +V+P LG F L+ AH R IK+ LD V Sbjct: 66 QNLGINAIYFTPIFQSASNHRYHTHDYYQVDPMLGGNEAFKELLDAAHQRNIKVVLDGVF 125 Query: 153 NHTGTAHPWFTEA-SSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQV 211 NH+ +F + + SP+ N++ P + G AG A F Sbjct: 126 NHSSRGFFFFHDVLENGPHSPWVNWFKIEGWPLSPYNGE--FPANYVGWAGNRALPEFNH 183 Query: 212 SD 213 + Sbjct: 184 DN 185 >5M99-B nrPDB Length = 505 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 86/353 (24%), Positives = 127/353 (35%), Gaps = 75/353 (21%) Query: 330 NIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDA 389 + +S+ ++ DLN+ + + WI++GVDG R+DA Sbjct: 136 HWKINSKGQKVWYFGLFGYNMPDLNHDSQ------KVREEVKKIVDFWISKGVDGFRIDA 189 Query: 390 VKHIYH---SETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGL 446 KHIY + +E+ + + F + + + D ++GEV S Sbjct: 190 AKHIYGWSWDDGIQESAEYFEWFRDYVLS------KKPDAILVGEVFS---GNTYDLSLY 240 Query: 447 PA-LFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSK 505 P +F F+ Y + G L NHD R S Sbjct: 241 PIPVFNFALMYSIRNYPEGQDG-------------MIENNWVEESFLFLENHDLHRFFSH 287 Query: 506 LGKSADK--------CKLAAA----VLLTSAGHPYIYYGEELGLYGTKDNG---DEYVRS 550 L + K K AA ++ T G P IYYG E+G G K +G DE VR Sbjct: 288 LQEHYKKFSESDYEFIKKRAALWYFLIFTLKGSPVIYYGGEIGTRGFKWHGPVYDEPVRE 347 Query: 551 PMLWGDSYTTNYTDKTDATVSKNVK--------------------TVADQQADTHSLLNI 590 PM W S T V KN +V +Q+ D SLLN Sbjct: 348 PMQWYASGTGEGQTFWTKEVYKNAGITFGNADVDGCIYDDPYDGFSVEEQENDPKSLLNF 407 Query: 591 YFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 + R + A+ G+ T +D+K + A+Y NEKLLV+ N Sbjct: 408 IRFILNFRKDHDAILNGDQTIF--------RDWKNLIAFYRESSNEKLLVVLN 452 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 56/120 (46%), Positives = 80/120 (66%), Gaps = 1/120 (0%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTK 121 + Y++ + S DSDGDG GD+NGV+QK+DYL +LG+ A+W P + +SYHGYD+TDY Sbjct: 6 VVYEIFIRSLYDSDGDGVGDINGVSQKVDYLRKLGIDAVWFMPFNEAVSYHGYDITDYYN 65 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFS 180 V GT D + ++ H GIK+ +D V+NHT HPWF +A +++ SPY +YY S Sbjct: 66 VEKDYGTMEDLENMIQVLHENGIKVIMDLVINHTSDEHPWFKDAVENTTSSPYWDYYIMS 125 >1LWJ-A nrPDB Length = 441 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 116/316 (36%), Gaps = 37/316 (11%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSE 400 F+ + DLNY + + + GVDG R DA KH+ +T E Sbjct: 145 FYRGLFGPFSPDLNYD------NPQVFDEMKRLVLHLLDMGVDGFRFDAAKHM--RDTIE 196 Query: 401 ENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEW 460 +N RF K F D+ + + E+ +E V + + + F + ++ Sbjct: 197 QNVRFWKYFLSDLKGIF-----------LAEIWAEARMVDEHGRIFGYMLNFDTSHCIKE 245 Query: 461 GINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGK-SADKCKLAAAV 519 + + I + A DY+ SNHD R +S G S +K KL+ ++ Sbjct: 246 AVWKENTRVLIESI-----ERAVIAKDYLPVNFTSNHDMSRLASFEGGFSKEKIKLSISI 300 Query: 520 LLTSAGHPYIYYGEELGLYGT-KDNGDEYVRSPMLWGDSY-TTNYTDKTDATVSKNVK-- 575 L T G P ++YG+ELG+ G + E V P W +S T + Sbjct: 301 LFTLPGVPLVFYGDELGMKGVYQKPNTEVVLDPFPWNESMCVEGQTFWKWPAYNGPFSGI 360 Query: 576 TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDN 635 +V Q+ D S+L+ TR R + + + + + D Sbjct: 361 SVEYQKRDPDSILSHTLGWTRFRKENQWIDRAKLEFLCKED--------KFLVYRLYDDQ 412 Query: 636 EKLLVIHNFGGTAMQL 651 L V HN G + Sbjct: 413 HSLKVFHNLSGEEVVF 428 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 47/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTK 121 I YQ+ + SF D + DG GD G+ + YL +LG+ +WL P+ +S+HGYDV D+ Sbjct: 2 IGYQIYVRSFRDGNLDGVGDFRGLKNAVSYLKELGIDFVWLMPVFSSISFHGYDVVDFYS 61 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSE 181 + G+E +F ++ H+ GIK+ LD ++HTG H WF +A + YR+YY ++ Sbjct: 62 FKAEYGSEREFKEMIEAFHDSGIKVVLDLPIHHTGFLHTWFQKALK-GDPHYRDYYVWAN 120 Query: 182 DPKTDIAAGK 191 +TD+ + Sbjct: 121 -KETDLDERR 129 >6AIJ-A nrPDB Length = 708 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 131/362 (36%), Gaps = 65/362 (17%) Query: 341 FHSHFCTDW-------------FADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRL 387 FH + TD+ AD+N+ A W+ GVDG+R Sbjct: 196 FHHNGGTDFSTIEDGIYKNLYDLADINHNNNAMDA------YFKSAIDLWLGMGVDGIRF 249 Query: 388 DAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLP 447 DAVKH+ F+ Y + + T + +G ++ D + + Sbjct: 250 DAVKHMPFGWQKS----FVSSIYGGDHPVF-----TFGEWYLGADQTDGDNIKFANESGM 300 Query: 448 ALFEFSFWYRLEWGINNSTGCY-FAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKL 506 L +F + + + T ++L+ + +Y ++ T + NHD DR Sbjct: 301 NLLDFEYAQEVREVFRDKTETMKDLYEVLASTESQYDYINN--MVTFIDNHDMDRFQVA- 357 Query: 507 GKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKT 566 G + A A+ LTS G P IYYG E + G +GD R+ M ++ TT Y Sbjct: 358 GSGTRATEQALALTLTSRGVPAIYYGTEQYMTG---DGDPNNRAMMTSFNTGTTAY---- 410 Query: 567 DATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPI 626 + +L LR + PA+A G T+ V N+ + K Sbjct: 411 ----------------------KVIQALAPLRKSNPAIAYGTTTERWVNNDVLIIERKFG 448 Query: 627 AAWYMTKDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGET-QQNTDSDSYTLKLGG 682 ++ + N + G LP +D + +L N T ++TL GG Sbjct: 449 SSAALVAINRNSSAAYPISGLLSSLPAGTYSDVLNGLLNGNSITVGSGGAVTNFTLAAGG 508 Query: 683 YA 684 A Sbjct: 509 TA 510 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 52/163 (31%), Positives = 72/163 (44%), Gaps = 38/163 (23%) Query: 40 VEGQWTALTASPDTWDETK---RADISYQLLLYSFADSD------GDGY----------- 79 + G T ASPDT + K D+ YQ++ FAD D GD + Sbjct: 12 LAGFATVAQASPDTSVDNKVNFSTDVIYQIVTDRFADGDRTNNPAGDAFSGDRSNLKLYF 71 Query: 80 -GDLNGVTQKLD--YLNQLGVKALWLS-PIHPCMS-----------YHGYDVTDYTKVNP 124 GD G+ K++ YL +GV ALW+S P+ S YHGY D+ + N Sbjct: 72 GGDWQGIIDKINDGYLTGMGVTALWISQPVENITSVIKYSGVNNTSYHGYWARDFKQTND 131 Query: 125 QLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGT---AHPWFTE 164 G +DF L+ AH IK+ +D+ NHT +P F E Sbjct: 132 AFGDFADFQNLIDTAHAHNIKVVIDFAPNHTSPADRDNPGFAE 174 >1QHO-A nrPDB Length = 686 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 102/476 (21%), Positives = 155/476 (32%), Gaps = 105/476 (22%) Query: 247 DNPDT--GTDNAKYLYYGEDICKKFY--------------DKGNNIYELTVDFESTWGLL 290 DN DT GTDN Y Y K+ D N ++ VDF Sbjct: 76 DNLDTLAGTDNTGYHGYWTRDFKQIEEHFGNWTTFDTLVNDAHQNGIKVIVDFVPNHSTP 135 Query: 291 IRTSNASFWPSGTKYGASSSSEKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWF 350 + ++++F G Y N G FD YFH + + Sbjct: 136 FKANDSTFAEGGALY------------------NNGTYMGNYFDDATKGYFHHNGDISNW 177 Query: 351 ADL------NYGPV-------DQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSE 397 D N+ Q + DAA +A G DGLR+DAVKH Sbjct: 178 DDRYEAQWKNFTDPAGFSLADLSQENGTIAQYLTDAAVQLVAHGADGLRIDAVKHF---- 233 Query: 398 TSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPA-------LF 450 N F K + + D +++GE + A + + + + Sbjct: 234 ----NSGFSKSLADKL-------YQKKDIFLVGEWYGDDPGTANHLEKVRYANNSGVNVL 282 Query: 451 EFSFWYRLEWGINNSTGCYF-AKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKS 509 +F + T + ++++ Y+ + I T + NHD R S Sbjct: 283 DFDLNTVIRNVFGTFTQTMYDLNNMVNQTGNEYKYKENLI--TFIDNHDMSRFLSVNSNK 340 Query: 510 ADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDAT 569 A+ A A +LTS G P IYYG E + G D Y R M D+ TT + + Sbjct: 341 AN-LHQALAFILTSRGTPSIYYGTEQYMAGGNDP---YNRGMMPAFDTTTTAFKE----- 391 Query: 570 VSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAW 629 +L LR A+ G T+ + N+ + K Sbjct: 392 ---------------------VSTLAGLRRNNAAIQYGTTTQRWINNDVYIYERKFFNDV 430 Query: 630 YMTKDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGETQQNTDSDSYTLKLGG 682 + N ++ G LP D + +L NG + N S+TL G Sbjct: 431 VLVAINRNTQSSYSISGLQTALPNGSYADYLSGLLGGNGISVSNGSVASFTLAPGA 486 Score = 118 bits (295), Expect = 9e-27, Method: Composition-based stats. Identities = 43/131 (32%), Positives = 61/131 (46%), Gaps = 30/131 (22%) Query: 57 TKRADISYQLLLYSFADSDGDGY---------------------GDLNGVTQKLDYLNQL 95 + + D+ YQ+++ F D D GDL GV QKL YL QL Sbjct: 5 SVKGDVIYQIIIDRFYDGDTTNNNPAKSYGLYDPTKSKWKMYWGGDLEGVRQKLPYLKQL 64 Query: 96 GVKALWLSPIHPCMS---------YHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 GV +WLSP+ + YHGY D+ ++ G + FD LV +AH GIK+ Sbjct: 65 GVTTIWLSPVLDNLDTLAGTDNTGYHGYWTRDFKQIEEHFGNWTTFDTLVNDAHQNGIKV 124 Query: 147 YLDYVMNHTGT 157 +D+V NH+ Sbjct: 125 IVDFVPNHSTP 135 >5OT1-A nrPDB Length = 765 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 78/399 (19%), Positives = 137/399 (34%), Gaps = 93/399 (23%) Query: 326 GNPA--NIMFDSQQITYFHSHFCTDW-------FADLNY-----GPVDQAGESPAYQAIA 371 GNPA ++ + Y+ F W A + + P + + Sbjct: 427 GNPAFLDVWEKGNESPYWDWFFVKKWPFKLGDGSAYVGWWGFGSLPKLNTANQEVREYLI 486 Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 AA WI G DG+R+D + T F+ ++ K+K D Y++GE Sbjct: 487 GAALHWIEFGFDGIRVDVPNEVLDPGT----------FFPELRKAVKEK--KPDAYLVGE 534 Query: 432 VL---------SEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYA 482 + +D + Y G L ++ G Y+A SY + Sbjct: 535 IWTLSPEWVKGDRFDSLMNYALGRDILLNYAKGLLSGESAMKMMGRYYA----SYGENVV 590 Query: 483 NYRSDYIEATKLSNHDEDRTSSKLGK----------SADKCKLAAAVLLTSAGHPYIYYG 532 + + +HD R + LG S + KL + +L G P + G Sbjct: 591 AMGFNLV-----DSHDTSRVLTDLGGGKLGDTPSNESIQRLKLLSTLLYALPGTPVTFQG 645 Query: 533 EELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYF 592 +E GL G K + DE R P+ W +LN Y Sbjct: 646 DERGLLGDKGHYDEQ-RYPIQWD--------------------------TVNEDVLNHYR 678 Query: 593 SLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLP 652 +L LR PAL M ++ + A++ +E L+V +++ A+ L Sbjct: 679 ALAELRKRVPALRSSAMRFYTAKGG--------VMAFFRGHHDEVLVVANSWKKPAL-LE 729 Query: 653 LTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 L + KV++ + + T+++ ++ + G Sbjct: 730 LPEGEWKVIWPEDFSPE---LLRGTVEVPAIGIIILERG 765 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 50/199 (25%), Positives = 84/199 (42%), Gaps = 45/199 (22%) Query: 56 ETKRADISYQLLLYSFADSDGDG------------------------------------- 78 E I+YQ+ F + + Sbjct: 286 EWVSNGITYQIFPDRFNNGNKSNDALALDHDELILNQVNPGQPILSNWSDPITPLHCCHQ 345 Query: 79 --YGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLV 136 GD+ G+T+KLDYL LGV ++++PI S HGYD DY +++P+ GTE + + Sbjct: 346 YFGGDIKGITEKLDYLQSLGVTIIYINPIFLSGSAHGYDTYDYYRLDPKFGTEDELREFL 405 Query: 137 TEAHNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYYSFSEDPKTDIAAGKIAMI 195 EAH RG+++ D+V NH G +P F + +ESPY +++ + P + G Sbjct: 406 DEAHRRGMRVIFDFVPNHCGIGNPAFLDVWEKGNESPYWDWFFVKKWP-FKLGDGS---- 460 Query: 196 TQEGAAGYNAAEWFQVSDE 214 G G+ + +++ Sbjct: 461 AYVGWWGFGSLPKLNTANQ 479 >4JCM-A nrPDB Length = 702 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 129/354 (36%), Gaps = 55/354 (15%) Query: 340 YFHSHFCTDWFADLN--YGP-----VDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKH 392 YF+++ +D+ N Y S + + ++ + W+ G+DG+R+DAV H Sbjct: 193 YFYNYGGSDFSDYENSIYRNLYDLASLNQQHSFIDKYLKESIQLWLDTGIDGIRVDAVAH 252 Query: 393 IYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEF 452 + + K F + Y + + G S + G+ AL +F Sbjct: 253 MPLG--------WQKAFISSVYDYNPVFTFGE--WFTGAQGSNHYHHFVNNSGMSAL-DF 301 Query: 453 SFWYRLEWGINNSTGCYF-AKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSAD 511 + + + N G D+L+ Q +Y + T + NHD DR + G+ Sbjct: 302 RYAQVAQDVLRNQKGTMHDIYDMLASTQ--LDYERPQDQVTFIDNHDIDRF-TVEGRDTR 358 Query: 512 KCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVS 571 + A LLTS G P IYYG E + G GD R M D TT Y Sbjct: 359 TTDIGLAFLLTSRGVPAIYYGTENYMTG---KGDPGNRKMMESFDQTTTAYQ-------- 407 Query: 572 KNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYM 631 + L LR A+A G+ + + ++ + + + Sbjct: 408 ------------------VIQKLAPLRQENKAVAYGSTKERWINDDVLIYERSFNGDYLL 449 Query: 632 TKDNEKLLVIHNFGGTAMQLP---LTDKIEKVLFVNGET-QQNTDSDSYTLKLG 681 N+ + + G ++P D ++ +L ++N DS+ L G Sbjct: 450 VAINKNVNQAYTISGLLTEMPAQVYHDVLDSLLDGQSLAVKENGTVDSFLLGPG 503 Score = 119 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 43/145 (29%), Positives = 63/145 (43%), Gaps = 29/145 (20%) Query: 42 GQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGY------------------GDLN 83 G+ A A+ D + ++ Y ++ F D D D GD Sbjct: 24 GEVHASNATNDLSNVNYAEEVIYHIVTDRFKDGDPDNNPQGQLFSNGCSDLTKYCGGDWQ 83 Query: 84 GVTQKLD--YLNQLGVKALWLSP----IHP-----CMSYHGYDVTDYTKVNPQLGTESDF 132 G+ +++ YL +G+ ALW+SP + SYHGY D+ K NP G DF Sbjct: 84 GIIDEIESGYLPDMGITALWISPPVENVFDLHPEGFSSYHGYWARDFKKTNPFFGDFDDF 143 Query: 133 DRLVTEAHNRGIKIYLDYVMNHTGT 157 RL+ AH IK+ +D+V NHT Sbjct: 144 SRLIETAHAHDIKVVIDFVPNHTSP 168 >4E2O-A nrPDB Length = 454 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 87/394 (22%), Positives = 143/394 (36%), Gaps = 78/394 (19%) Query: 319 DFKLTNAGNPANIMFDSQQITYFH----SHFCTDWFADLN---YGPVDQAGESPAYQ-AI 370 DF + G + D + +FH D N YG D A E+P + + Sbjct: 113 DFVANHVGYNHPWLHDPTKKDWFHPKKEIFDWNDQTQLENGWVYGLPDLAQENPEVKTYL 172 Query: 371 ADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 DAAK WI +DG RLD V+H+ S F + F +++ + K DF+++ Sbjct: 173 IDAAKWWIKETDIDGYRLDTVRHVPKS--------FWQEFAKEVKSVKK------DFFLL 218 Query: 430 GEVLSEYDK-VAPYYK-GLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSD 487 GEV S+ + +A Y K G+ ++ + ++ + ++ Y Sbjct: 219 GEVWSDDPRYIADYGKYGIDGFVDYPLYGAVKQSLARR-DASLRPLYDVWEYNKTFYDRP 277 Query: 488 YIEATKLSNHDEDRT----SSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN 543 Y+ + L NHD R + KLA L T+ G P +YYG E+ + G +D Sbjct: 278 YLLGSFLDNHDTVRFTKLAIDNRNNPISRIKLAMTYLFTAPGIPIMYYGTEIAMNGGQDP 337 Query: 544 GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPA 603 + R M D +AD +++ + LR P+ Sbjct: 338 DN---RRLM--------------------------DFRADPE-IIDYLKKIGPLRQELPS 367 Query: 604 LAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAM-------QLPLTDK 656 L G+ T + +A +E ++ N QLP + Sbjct: 368 LRRGDFTLL--------YEKDGMAVLKRQYQDETTVIAINNTSETQHVHLTNDQLPKNKE 419 Query: 657 IEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKL 690 + L + D D Y L L + V+KL Sbjct: 420 LRGFLLDDLV---RGDEDGYDLVLDRETAEVYKL 450 Score = 142 bits (359), Expect = 4e-34, Method: Composition-based stats. Identities = 47/138 (34%), Positives = 71/138 (51%), Gaps = 21/138 (15%) Query: 56 ETKRADISYQLLLYSFADSDGDG-------------YGDLNGVTQKLDYLNQLGVKALWL 102 T + + Y +++ F + D GDL GVT KLDY+ ++G A+WL Sbjct: 5 RTWQDEAIYFIMVDRFNNMDPTNDQNVNVNDPKGYFGGDLKGVTAKLDYIKEMGFTAIWL 64 Query: 103 SPIHPCM--SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 +PI M YHGY + D+ +V+P GT D LV EAH R +K+ LD+V NH G HP Sbjct: 65 TPIFKNMPGGYHGYWIEDFYQVDPHFGTLGDLKTLVKEAHKRDMKVILDFVANHVGYNHP 124 Query: 161 WFTEASSSSESPYRNYYS 178 W + + ++++ Sbjct: 125 WLHDPTK------KDWFH 136 >5A2B-A nrPDB Length = 497 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 81/355 (22%), Positives = 137/355 (38%), Gaps = 68/355 (19%) Query: 319 DFKLTNAGNPANIMFDSQQITYFHS-----HFCTDWFADLNY--GPVDQAGESPAYQ-AI 370 DF + + G + D + +FH ++ + + G D A E+P + + Sbjct: 146 DFVVNHTGYNHPWLNDPAKKDWFHEKKDIFNWANQQEVENGWLFGLPDLAQENPEVKTYL 205 Query: 371 ADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMI 429 D AK WI +DG RLD VKH+ K F+++ K DF+++ Sbjct: 206 FDVAKWWIQETDIDGYRLDTVKHVP------------KWFWDEFAKEV--KSVKQDFFLL 251 Query: 430 GEVLSEYDK-VAPYYK-GLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSD 487 GEV + + VA Y K G+ AL +F F Y+ I ++ +++ A Y Sbjct: 252 GEVWHDDPRYVAEYGKHGIDALIDFPF-YKEASTIFSNVDQSLEPLYNVWKRNVAFYERP 310 Query: 488 YIEATKLSNHDEDRTSSKLGKSA----DKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN 543 Y+ T L NHD R + ++ + KL L ++ G P +YYG E+ L G +D Sbjct: 311 YLLGTFLDNHDTVRFTRLALQNRINPVTRLKLGLTYLFSAPGIPIMYYGTEIALDGGEDP 370 Query: 544 GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPA 603 + R M N +T L++ L LR P+ Sbjct: 371 DN---RRLM--------------------NFRT-------DKELIDYVTKLGELRAKLPS 400 Query: 604 LAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIE 658 L G+ + +A + T + E ++ N ++ L ++E Sbjct: 401 LRRGDFELL--------YEKDGMALFKRTYEKETTVIAINNTSKTQKVTLDGELE 447 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 47/142 (33%), Positives = 73/142 (51%), Gaps = 21/142 (14%) Query: 56 ETKRADISYQLLLYSFADSDGD-------------GYGDLNGVTQKLDYLNQLGVKALWL 102 T + + Y +++ F + + GDL G+ KLDY+ ++G A+WL Sbjct: 38 RTWQDERIYFIMVDRFNNGNPKNDYEVDVHDPKAYHGGDLQGIIDKLDYIKEMGFTAIWL 97 Query: 103 SPIH--PCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 +PI YHGY + D+ KV GT DF RLV EAH R +K+ LD+V+NHTG HP Sbjct: 98 TPIFANEKGGYHGYWIEDFYKVEEHFGTLDDFKRLVKEAHKRDMKVILDFVVNHTGYNHP 157 Query: 161 WFTEASSSSESPYRNYYSFSED 182 W + + ++++ +D Sbjct: 158 WLNDPAK------KDWFHEKKD 173 >6A0L-A nrPDB Length = 471 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 112/340 (32%), Gaps = 67/340 (19%) Query: 355 YGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMN 414 Y P A D A+ WI +G+DG RLD I N F + F Sbjct: 189 YLPKWNAYNPEVRHHHLDVARYWIDQGIDGWRLDVPYFI--------NHTFWREFR---- 236 Query: 415 AYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYR-LEWGINNSTGCYFAKD 473 KG ++D Y++ E E+ + +G A ++ R L G G + Sbjct: 237 --TAVKGKSEDLYIVAE---EWRSPVEWLQGDTADGTMNYTARDLILGFTADGGIDASAL 291 Query: 474 ILSYQQKYANYRSDYIEATK--LSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYY 531 +A + + L +HD +R ++ + L+ A+L + G P +YY Sbjct: 292 AAGLNALHAEIPAGFHRGMLNLLGSHDTERVLTRHAGDVEAALLSYALLFSLEGAPMVYY 351 Query: 532 GEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIY 591 G+E+GL G D G R M W + LL+ Sbjct: 352 GDEVGLTGDNDPG---CRGAMPWNEESW------------------------NTRLLDGI 384 Query: 592 FSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQL 651 + R PA+ G T ++ ++ A + +E+ VI + G Sbjct: 385 RTFAAFRAHQPAMRRGRQTAVALDADT--------IAIVRSGGDERAAVIVHRG------ 430 Query: 652 PLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 E + D+ T+ LG + Sbjct: 431 ------EGTTVDTASIPELAPLDADTVVLGPLGTASLATA 464 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 50/180 (27%), Positives = 77/180 (42%), Gaps = 24/180 (13%) Query: 53 TWDETKRADISYQLLLYSFADSDG----------------DGY--GDLNGVTQKLDYLNQ 94 T + + YQ+ FA++D D + GDL G+ LD++ Sbjct: 23 TAPDWLADAVFYQIFPERFANADPSLDPQNVVPWGSTPTPDNFFGGDLQGIIDHLDHIVA 82 Query: 95 LGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNH 154 LG AL+L+PI + H YD DY ++ +LGT F L+ E RGI+I LD V+NH Sbjct: 83 LGANALYLTPIFEADTNHRYDAKDYFSIDHRLGTLETFHALMAECRARGIRIVLDAVLNH 142 Query: 155 TGTAHPWFTE-ASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSD 213 G H F + + ++S Y N++S P T +G + + Sbjct: 143 CGDGHWAFADVVENEADSAYVNWFSVEGFPVTAHPT-----PNYRTCSGCYYLPKWNAYN 197 >3M07-A nrPDB Length = 618 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 40/158 (25%), Positives = 59/158 (37%), Gaps = 11/158 (6%) Query: 12 WLSMLMAFMT-------ACSDDKNITDPAPEPEPP-VEGQWTALTASPDTWDET-KRADI 62 W ++ +A +T SD + DPA + V G + TW T + Sbjct: 74 WFTLDVAGVTPGTEYNFVLSDGMVVPDPASRAQKTDVNGPSYVVDPGSYTWRNTGWKGSR 133 Query: 63 SYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYT 120 Q ++Y G KL YL +LGV + + P+ GYD Sbjct: 134 WEQAVVYEMHTGTFTPEGTFRAAIAKLPYLAELGVTVIEVMPVAQFGGERGWGYDGVLLY 193 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 + GT DF + AH G+ + LD V+NH G Sbjct: 194 APHSAYGTPDDFKAFIDAAHGYGLSVVLDIVLNHFGPE 231 Score = 63.6 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 63/359 (17%), Positives = 101/359 (28%), Gaps = 66/359 (18%) Query: 354 NYGPVDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVK------------HIYHSETSE 400 +G + I +A W+ +DGLR DA+ I + Sbjct: 250 PWGNGIAYDVDAVRRYIIEAPLYWLTEYHLDGLRFDAIDQIEDSSARHVLVEIAQRIRED 309 Query: 401 ENPRFLKMFYEDMNAYYKQKGHTDDF---YMIGEVLSEYDKVAPYYKGLPALFEFSFWYR 457 R + + ED D E ++ +F Sbjct: 310 ITDRPIHLTTEDSRNIISLHPRDQDGNAPLFTAEWNDDFHNAVH-------VFATGETQA 362 Query: 458 LEWGINNSTGCYFAKDILSYQQKYANY--------------RSDYIEATKLSNHDE---- 499 ++ + A+ + + + NHD+ Sbjct: 363 YYNDFADAPEKHLARALAEGFAYQGEISPQTGEPRGVKSTGQPPVAFVDFIQNHDQVGNR 422 Query: 500 ---DRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELG-----LYGTKDNGDE--YVR 549 DR + G A++ K+ A LL S P ++ GEE G L+ T +GD VR Sbjct: 423 AQGDRLITLAG--AERTKVLLATLLLSPHIPLLFMGEEYGESRPFLFFTDFHGDLARAVR 480 Query: 550 --SPMLWGDSYTTNYTDKTDATVSKNVKTVADQQ--ADTHSLLNIYFSLTRLRNTY--PA 603 + D N D + K QQ + + L L LR + P Sbjct: 481 EGRAKEFADHAGENVPDPNAPETFQRSKLNWKQQHSEEGKAWLAFTRELLLLRQKHIVPL 540 Query: 604 LAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLF 662 L+ + IA + L + N A + L D K LF Sbjct: 541 LS----AARESSGTVLQTAPGFIAVSWRFPGG-TLSLALNIS--ATTVLLPDLPGKTLF 592 >5BN7-A nrPDB Length = 616 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 110/324 (33%), Gaps = 72/324 (22%) Query: 350 FADLNYGPVDQAGESPAYQAIADAAKGWIAR--GVDGLRLDAVKHIYHSETSEENPRFLK 407 L+Y + Y+ + W+ +DG RLD V + + + N + + Sbjct: 300 LPKLDYQSESLV--NEIYRGEDSIVRHWLKAPWNMDGWRLDVVHMLGEAGGARNNMQHVA 357 Query: 408 MFYEDMNAYYKQKGHTDDFYMIGE--------VLSEYDKVAPYYKGLPALFEFSFWYRLE 459 E K + Y++GE + ++ + A Y+G F F Sbjct: 358 GITE------AAKETQPEAYIVGEHFGDARQWLQADVEDAAMNYRG----FTFPL----- 402 Query: 460 WGINNSTGCYFAKDILSYQQKYA---NYRSDYIEA------TKLSNHDEDRTSSKLGKSA 510 WG +T + + Q A NYR+ +L +HD R + LG+ Sbjct: 403 WGFLANTDISYDPQQIDAQTCMAWMDNYRAGLSHQQQLRMFNQLDSHDTARFKTLLGRDI 462 Query: 511 DKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATV 570 + LA L T G P IYYG+E+GL G D + R P W Sbjct: 463 ARLPLAVVWLFTWPGVPCIYYGDEVGLDG---KNDPFCRKPFPW---------------- 503 Query: 571 SKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 + +L +Y + LR AL G + + + Sbjct: 504 --------QVEKQDTALFALYQRMIALRKKSQALRHGGCQVLYAEDN--------VVVFV 547 Query: 631 MTKDNEKLLVIHNFGGTAMQLPLT 654 + +++LV N G A ++ L Sbjct: 548 RVLNQQRVLVAINR-GEACEVVLP 570 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 61/207 (29%), Positives = 86/207 (41%), Gaps = 54/207 (26%) Query: 51 PDTWDETKRADISYQLLLYSFA-------------------------DSD--------GD 77 PD + I YQ+ FA D D G Sbjct: 115 PDIGPQWAADQIFYQIFPDRFARSLPREAEQDHVYYHHAAGQEIILRDWDEPVTAQAGGS 174 Query: 78 GY--GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRL 135 + GDL+G+++KL YL +LGV AL+L+P+ S H YD DY V+PQ G + RL Sbjct: 175 TFYGGDLDGISEKLPYLKKLGVTALYLNPVFKAPSVHKYDTEDYRHVDPQFGGDGALLRL 234 Query: 136 VTEAHNRGIKIYLDYVMNHTGTAHPWFTE-------ASSSSESPYRNYYSFSEDPKTDIA 188 G+++ LD V NH+G +H WF A + ESP+R++YSFS+D Sbjct: 235 RHNTQQLGMRLVLDGVFNHSGDSHAWFDRHNRGTGGACHNPESPWRDWYSFSDDG----- 289 Query: 189 AGKIAMITQEGAAGYNAAEWFQVSDET 215 T GY + E+ Sbjct: 290 -------TALDWLGYASLPKLDYQSES 309 >3HJE-A nrPDB Length = 704 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 55/168 (32%), Positives = 77/168 (45%), Gaps = 20/168 (11%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPC--MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNR 142 + +LDY +LGV L+LSP+ S HGYDV DY +N +LG E ++ RL+ EA ++ Sbjct: 17 IRNRLDYFVELGVTHLYLSPVLKARPGSTHGYDVVDYNTINDELGGEEEYIRLIDEAKSK 76 Query: 143 GIKIYLDYVMNHTGTAHP-W--FTEASSSSESPYRNYYSFSED------PKTDIAAGKIA 193 G+ I D V NH H W S Y NY+ F E+ P KI Sbjct: 77 GLGIIQDIVPNHMAVHHTNWRLMDVLKKGRHSRYYNYFDFYEEEEKIRIPILGDRNFKIT 136 Query: 194 MITQEGAAGYNAAEWFQVSDETAA----VKGLLKFT----LDWSNAPS 233 + E Y F ++DE ++ LLK +DW + PS Sbjct: 137 YVNDEPYLDY-YGNLFPINDEGRNYLNDIEKLLKVQYYELVDWRDYPS 183 Score = 33.9 bits (76), Expect = 0.25, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 45/150 (30%), Gaps = 21/150 (14%) Query: 378 IARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEV--LSE 435 ++ VDG R+D + ++ E N + + IGE Sbjct: 212 LSFEVDGYRIDHIDGLFKPEEY---------LRRLKNKIGNKHIFVEKILSIGEKLRWDF 262 Query: 436 YDKVAPY-YKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKL 494 D Y + L ++ N + + ++K I+ Sbjct: 263 IDGTTGYDFLNYSNLLFTDNEDKMTEIYKNILDIDLDELVKETKKKI-------IDTLF- 314 Query: 495 SNHDEDRTSSKLGKSADKCKLAAAVLLTSA 524 HD +R S LG + ++ K + L Sbjct: 315 -KHDIERISMMLGVNYEEIKEFLSCLKVYR 343 >4AEF-A nrPDB Length = 645 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 111/293 (37%), Gaps = 51/293 (17%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSE 400 + S F LN+ + I + W +GVDG R+D + Sbjct: 370 YESFFSVWIMPRLNHD------NPKVREFIKNVILFWTNKGVDGFRMDVAHGVP------ 417 Query: 401 ENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSE-----YDKV--APYYKGLPALFEFS 453 P K E + + Y+IGEV+ + +DK Y+ A+ F Sbjct: 418 --PEVWKEVREALPK---------EKYLIGEVMDDARLWLFDKFHGVMNYRLYDAILRF- 465 Query: 454 FWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKC 513 +G T F ++ Y ++Y+ L NHD +R +G K Sbjct: 466 ------FGYEEITAEEFLNELELLSSYYG--PAEYLMYNFLDNHDVERFLDIVG-DKRKY 516 Query: 514 KLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKN 573 A L+T G P ++YG+E+GL G G E R+PMLW + D + + Sbjct: 517 VCALVFLMTYKGIPSLFYGDEIGLRGINLQGMESSRAPMLWNEEE-------WDQRILEI 569 Query: 574 VKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSV----YNESQEKD 622 KT+ + + +LL F + + + +M + ++ Y+ S+ K+ Sbjct: 570 TKTLVKIRKNNKALLFGNFVPVKFKRKFMVYKREHMGERTIVAINYSNSRVKE 622 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 61/215 (28%), Positives = 100/215 (46%), Gaps = 27/215 (12%) Query: 42 GQWTALTASPDTWDETKRADISYQLLLYSFADS----------DGDGYGDLNGVTQKLDY 91 GQ+ A S + + + YQ++ FA S D GDL G+ +K+D+ Sbjct: 189 GQFKARPFSIE-FPTWVIDRVFYQIMPDKFARSRKIQGIAYPKDKYWGGDLIGIKEKIDH 247 Query: 92 LNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYV 151 L LG+ A++L+PI ++YHGYD+ DY V +LG + F L++E IK+ LD V Sbjct: 248 LVNLGINAIYLTPIFSSLTYHGYDIVDYFHVARRLGGDRAFVDLLSELKRFDIKVILDGV 307 Query: 152 MNHTGTAHPWFTEASSSSES-PYRNYYSFSEDPKTDIAAGKIAMIT---QEGA-----AG 202 +HT HP+F + E+ ++N+Y + P +I +E G Sbjct: 308 FHHTSFFHPYFQDVVRKGENSSFKNFYRIIKFPVVSKEFLQILHSKSSWEEKYKKIKSLG 367 Query: 203 YNAAEWFQV------SDETAAVKGLLK-FTLDWSN 230 +N +F V + + V+ +K L W+N Sbjct: 368 WNYESFFSVWIMPRLNHDNPKVREFIKNVILFWTN 402 >1EHA-A nrPDB Length = 558 Score = 154 bits (390), Expect = 9e-38, Method: Composition-based stats. Identities = 50/186 (26%), Positives = 78/186 (41%), Gaps = 15/186 (8%) Query: 22 ACSDDKNITDPAPEPEPP-VEGQWTALTASPDTWDET---KRADISYQLLLYSFADSDGD 77 D I DPA +P V G + S + +ET K I Y++ + +F Sbjct: 59 VLDDASEIPDPASRYQPEGVHGPSQIIQESKEFNNETFLKKEDLIIYEIHVGTFTPE--- 115 Query: 78 GYGDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRL 135 G GV +KLDYL LG+ A+ + PI P GYD V G F +L Sbjct: 116 --GTFEGVIRKLDYLKDLGITAIEIMPIAQFPGKRDWGYDGVYLYAVQNSYGGPEGFRKL 173 Query: 136 VTEAHNRGIKIYLDYVMNHTGTAHPWFTEA----SSSSESPYRNYYSFSEDPKTDIAAGK 191 V EAH +G+ + LD V NH G + + S ++P+ ++F + ++ Sbjct: 174 VDEAHKKGLGVILDVVYNHVGPEGNYMVKLGPYFSQKYKTPWGLTFNFDDAESDEVRKFI 233 Query: 192 IAMITQ 197 + + Sbjct: 234 LENVEY 239 Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 88/292 (30%), Gaps = 42/292 (14%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHSET 398 YF + T W N+ D A + I + + WI VDG RLDAV I + Sbjct: 206 YFSQKYKTPWGLTFNF---DDAESDEVRKFILENVEYWIKEYNVDGFRLDAVHAIIDTSP 262 Query: 399 SEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRL 458 L+ + ++ Y + D V + + Y + +F Sbjct: 263 K----HILEEIADVVHKYNRIVIAESDLNDPRVVNPK--EKVGYNIDAQWVDDFHHSIHA 316 Query: 459 EWGINNS---TGCYFAKDILSYQQKYANYRSDYIE------------------ATKLSNH 497 T DI+ + Y Y + NH Sbjct: 317 YLTGERQGYYTDFGNLDDIVKSYKDVFVYDGKYSNFRRKTHGEPVGELDGCNFVVYIQNH 376 Query: 498 DE-------DRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRS 550 D+ +R + + K+AAA+ L S P I+ GEE G ++ S Sbjct: 377 DQVGNRGKGERIIKLV--DRESYKIAAALYLLSPYIPMIFMGEEYGEENPFYFFSDFSDS 434 Query: 551 PMLWGDSYTTNYTDKTDATVSKNVKTVADQQ--ADTHSLLNIYFSLTRLRNT 600 ++ G + D A + + + Y L ++R Sbjct: 435 KLIQGVREGRKKENGQDTDPQDESTFNASKLSWKIDEEIFSFYKILIKMRKE 486 >4AEE-A nrPDB Length = 696 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 52/162 (32%), Positives = 77/162 (47%), Gaps = 18/162 (11%) Query: 55 DETKRADISYQLLLYSFADSDGDG-----------------YGDLNGVTQKLDYLNQLGV 97 + YQ+ + SF + D + GDL G+ + +D+L LGV Sbjct: 220 PRWYMGTVYYQIFIDSFDNGDPNNDPPNRIKKTVPREYGYYGGDLAGIMKHIDHLEDLGV 279 Query: 98 KALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGT 157 + ++L+PI SYH YD DY ++ LGT DF++LV H+R IKI LD M+HT Sbjct: 280 ETIYLTPIFSSTSYHRYDTIDYKSIDKYLGTMEDFEKLVQVLHSRKIKIVLDITMHHTNP 339 Query: 158 AHPWFTEASSSSES-PYRNYYSFSEDPKTDIAAGKIAMITQE 198 + F +A E+ PY +SF P +I + I E Sbjct: 340 CNELFVKALREGENSPYWEMFSFLSPPPKEIVELMLKYIDGE 381 Score = 141 bits (356), Expect = 9e-34, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 109/322 (33%), Gaps = 57/322 (17%) Query: 337 QITYFHSHFCTDW---FADLN-YGPVDQAGESP-AYQAIADAAKGWIARGVDGLRLDAVK 391 + Y +F + A N + ++P D K WI +G+DG R+D Sbjct: 386 RELYKLDYFRNNKPFYEAFFNIWLMAKFNHDNPRTVDYFIDITKFWIDKGIDGFRIDVAM 445 Query: 392 HIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFE 451 I++S ++K +YE + Y DF ++GE L+E ++ Y + Sbjct: 446 GIHYS--------WMKQYYEYIKNTY------PDFLVLGE-LAENPRIYMDYFDSAMNYY 490 Query: 452 FSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSAD 511 F I + +Y++ + L +HD R S + + Sbjct: 491 LRKAILELLIYKRIDLNEFISRINNVYAYIPHYKALSL-YNMLGSHDVPRIKSMVQNN-K 548 Query: 512 KCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVS 571 KL ++ G P IYYG+E+GL G +D + R PM+W Sbjct: 549 LLKLMYVLIFALPGSPVIYYGDEIGLEGGRDPDN---RRPMIWDRGNW------------ 593 Query: 572 KNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYM 631 L L R+ + ++ G E + Sbjct: 594 ------------DLELYEHIKKLIRIYKSCRSMRHGYF--------LVENLGSNLLFIKR 633 Query: 632 TKDNEKLLVIHNFGGTAMQLPL 653 +NE+++ + N + + L Sbjct: 634 WINNEEIIFLLNVSSKDISVDL 655 >2Z1K-A nrPDB Length = 475 Score = 148 bits (373), Expect = 9e-36, Method: Composition-based stats. Identities = 59/211 (27%), Positives = 83/211 (39%), Gaps = 38/211 (18%) Query: 57 TKRADISYQLLLYSFADS---------------------DGDGYGDLNGVTQKLDYLNQL 95 YQ+ F + G G L GV +KL YL L Sbjct: 3 WYEGAFFYQIFPDRFFRAGPPGRPAPAGPFEPWEAPPTLRGFKGGTLWGVAEKLPYLLDL 62 Query: 96 GVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 GV+A++L+P+ + H Y DY +V+P LG L+ AH G+++ LD V NHT Sbjct: 63 GVEAIYLNPVFASTANHRYHTVDYFQVDPILGGNEALRHLLEVAHAHGVRVILDGVFNHT 122 Query: 156 GTAHPWFTEASSSSE-SPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDE 214 G F + E SPYR++Y P A E G +V E Sbjct: 123 GRGFFAFQHLMENGEQSPYRDWYHVKGFPLKAYTA----HPNYEAWWGNPELPKLKV--E 176 Query: 215 TAAVKGLL--------KFTLD-WS-NAPSPI 235 T AV+ L +F +D W + P+ I Sbjct: 177 TPAVREYLLAVAEHWIRFGVDGWRLDVPNEI 207 Score = 144 bits (364), Expect = 9e-35, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 108/295 (36%), Gaps = 59/295 (20%) Query: 354 NYGPVDQAGESP-AYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 N E+P + + A+ WI GVDG RLD I +P F + F + Sbjct: 167 NPELPKLKVETPAVREYLLAVAEHWIRFGVDGWRLDVPNEIP-------DPTFWREFRQ- 218 Query: 413 MNAYYKQKGHTDDFYMIGEVLSE---------YDKVAPYYKGLPALFEFSFWYRLEWGIN 463 + KG + Y++GE+ E +D V Y A+ F L+ + Sbjct: 219 -----RVKGANPEAYIVGEIWEEADFWLQGDMFDAVMNYPLAR-AVLGFVGGEALDRDLA 272 Query: 464 NSTGCYFAKDIL------SYQQKYANYRSDYIEA--TKLSNHDEDRTSSKLGKSADKCKL 515 TG + + + + YR + + A L++HD R S + S ++ +L Sbjct: 273 AQTGLGRIEPLQALAFSHRLEDLFGRYRPEVVRAQMNLLTSHDTPRLLSLMRGSVERARL 332 Query: 516 AAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVK 575 A A+L G+P +YYGEE+G+ G KD + R M+W ++ Sbjct: 333 ALALLFLLPGNPTVYYGEEVGMAGGKDPEN---RGGMVWEEARW---------------- 373 Query: 576 TVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 L L RLR +PAL + + P A Sbjct: 374 --------QKDLRETVKRLARLRKEHPALRTAPYLRIYAQDGHLAFARGPYLAVV 420 >5Z0U-A nrPDB Length = 626 Score = 144 bits (364), Expect = 9e-35, Method: Composition-based stats. Identities = 58/188 (30%), Positives = 81/188 (43%), Gaps = 31/188 (16%) Query: 48 TASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQ-LGVKALWLSPIH 106 W + AD Y L F GDL G+ QKL Y+ + LG L+L+PI Sbjct: 163 PTEKKAWGSSVYADPGYDNSLVFFG-------GDLAGIDQKLGYIKKTLGANILYLNPIF 215 Query: 107 PCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAH--NRGIK--IYLDYVMNHTGTAHPWF 162 + H YD DY V+P G S L+ + H G K + LD V NHTG +HPWF Sbjct: 216 KAPTNHKYDTQDYMAVDPAFGDNSTLQTLINDIHSTANGPKGYLILDGVFNHTGDSHPWF 275 Query: 163 TE--------ASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDE 214 + A S SP+ NYY+F P + G+N+ + Sbjct: 276 DKYNNFSSQGAYESQSSPWYNYYTFYTWPD-----------SYASFLGFNSLPKLNYGNS 324 Query: 215 TAAVKGLL 222 +AV+G++ Sbjct: 325 GSAVRGVI 332 Score = 144 bits (364), Expect = 1e-34, Method: Composition-based stats. Identities = 72/345 (20%), Positives = 119/345 (34%), Gaps = 70/345 (20%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIA--RGVDGLRLDAVKHIYHSET 398 + S + LNYG A Y AK ++ VDG RLDA +++ H Sbjct: 307 YASFLGFNSLPKLNYGNSGSAVRGVIYNNSNSVAKTYLNPPYSVDGWRLDAAQYVDHQIW 366 Query: 399 SE---------ENPRFLKMFYEDMNAYYKQKGHTD---DFYMIGEVLSEYDKVAPYYKGL 446 SE N + ++ + N + Q D +F + +SE+ Y Sbjct: 367 SEFRNAVKGVNSNAAIIGEYWGNANPWTAQGNQWDAATNFDGFTQPVSEWITGKDYQNNS 426 Query: 447 PALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEAT--KLSNHDEDRTSS 504 ++ F L ANY ++ ++ LSNHD R ++ Sbjct: 427 ASISTTQFDSWLR-------------------GTRANYPTNVQQSMMNFLSNHDITRFAT 467 Query: 505 KLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTD 564 + G K LA +T G P IYYG+E G+ G D + R W Sbjct: 468 RSGGDLWKTYLALIFQMTYVGTPTIYYGDEYGMQGGADPDN---RRSFDW---------- 514 Query: 565 KTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYK 624 Q ++S + + L +RN YPAL G+ D Sbjct: 515 --------------SQATPSNSAVALTQKLITIRNQYPALRTGSFMTLITD------DTN 554 Query: 625 PIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQ 669 I ++ + ++ V+ N ++ + + ++ NG T Sbjct: 555 KIYSYGRFDNVNRIAVVLN--NDSVSHTVNVPVWQLSMPNGSTVT 597 >3UER-A nrPDB Length = 655 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 47/139 (33%), Positives = 60/139 (43%), Gaps = 12/139 (8%) Query: 53 TWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIH---PCM 109 W + + Y FA G L GV ++LDYL LGVK L L P+ Sbjct: 89 DWLQRPEM-VGYVAYTDRFA-------GTLKGVEERLDYLEGLGVKYLHLMPLLRPREGE 140 Query: 110 SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSS 169 + GY V DY V P LGT D L RGI + LD V+NH H W +A + Sbjct: 141 NDGGYAVQDYRAVRPDLGTMDDLSALARALRGRGISLVLDLVLNHVAREHAWAQKAR-AG 199 Query: 170 ESPYRNYYSFSEDPKTDIA 188 + YR Y+ D + A Sbjct: 200 DPKYRAYFHLFPDRRGPDA 218 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 59/437 (13%), Positives = 116/437 (26%), Gaps = 100/437 (22%) Query: 328 PANIMFDSQQITY-----FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGV 382 P N +D + + + W DLN+ + D RGV Sbjct: 232 PGNFSWDEEIGEGEGGWVWTTFNSYQW--DLNW------ANPDVFLEFVDIILYLANRGV 283 Query: 383 DGLRLDAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYD 437 + RLDA+ I+ + E + + + L Y Sbjct: 284 EVFRLDAIAFIWKRLGTDCQNQPEVHHLTRALRAAARIVAPAVAFKAEAIVAPADLIHYL 343 Query: 438 KV-APYYKGLPALFEFSFW--------------------------------------YRL 458 A + K + S + Sbjct: 344 GTRAHHGKVSDMAYHNSLMVQLWSSLASRNTRLFEEALRAFPPKPTSTTWGLYVRCHDDI 403 Query: 459 EWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS---------NHDEDRTSS----- 504 W I++ + +++ +++ S + N D + S Sbjct: 404 GWAISDEDAARAGLNGAAHRHFLSDFYSGQFPGSFARGLVFQYNPVNGDRRISGSAASLA 463 Query: 505 ------------KLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPM 552 ++ + + L V+L G P +Y G+EL L D +P Sbjct: 464 GLEAALETGDPGRIEDAVRRLLLLHTVILGFGGVPLLYMGDELALLNDYAFEDVPEHAP- 522 Query: 553 LWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNI-YFSLTRLRNTYPALAEGNMTK 611 D+ + A + V + + +N L R+R P L Sbjct: 523 ---DNRWVHRPQMDWAL----AERVRQEPSSPAGRVNTGLRHLLRVRRDTPQL------H 569 Query: 612 HSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTD--KIEKVLFVNGETQQ 669 S+ ++ ++ ++NF + LP + + + Sbjct: 570 ASIESQVLPSPDSRALLLRRDHPLGGMVQVYNFSEETVMLPSHVLRDVLGDHVQDRLSGS 629 Query: 670 NTDSDSYTLKLGGYASV 686 D T++L GY ++ Sbjct: 630 AFRLDRPTVRLEGYRAL 646 >3VM7-A nrPDB Length = 492 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 54/190 (28%), Positives = 76/190 (40%), Gaps = 37/190 (19%) Query: 49 ASPDTWDETKRADISYQLLLYSFADSDGD------------GYGDLNGVTQKLDYLNQLG 96 A+PD W R+ YQ+L FA DG G+ G+ +LDY+ +G Sbjct: 22 ATPDEW----RSRSIYQVLTDRFARGDGSPDAPCDTGARKYCGGNYRGLISQLDYIQGMG 77 Query: 97 VKALWLSPI-------HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLD 149 ++W+SPI YHGY TD +N GTE D L E H RG+ + +D Sbjct: 78 FDSVWISPITKQFEDDWNGAPYHGYWQTDLYALNEHFGTEEDLRALADELHARGMFLMVD 137 Query: 150 YVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEG------AAGY 203 V+NH G W +A+S S + + S +I Q G Sbjct: 138 VVINHNG----WPGDAASIDYSQFNPFNS----SDYYHPPCEINYDDQTSVEQCWLYTGA 189 Query: 204 NAAEWFQVSD 213 NA + D Sbjct: 190 NALPDLKTED 199 Score = 70.9 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 46/241 (19%), Positives = 75/241 (31%), Gaps = 44/241 (18%) Query: 328 PANIMFDSQQ--ITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWI-----AR 380 P I +D Q + + + DL + + Q D WI Sbjct: 169 PCEINYDDQTSVEQCW-LYTGANALPDL------KTEDPHVSQVHND----WIADLVSKY 217 Query: 381 GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVA 440 +DGLR+D KH+ N Y +GEV Sbjct: 218 SIDGLRIDTTKHVDKPAIGSFNDA-------------------AGVYAVGEVYHGDPAYT 258 Query: 441 -PYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDE 499 PY + + F +Y L + +G ++ + + + + + T NHD Sbjct: 259 CPYQDWVDGVLNFPVYYPLIDAFKSPSGTMWSL-VDNINKVFQTCNDPRLLGTFSENHDI 317 Query: 500 DRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYT 559 R +S + K A + G P +Y G+E G D + LW + Sbjct: 318 PRFAS-YTQDLALAKNVLAFTILFDGIPIVYAGQEQQYSGDSDPYNREA----LWLSGFN 372 Query: 560 T 560 T Sbjct: 373 T 373 >6IRT-A nrPDB Length = 647 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 125/334 (37%), Gaps = 50/334 (14%) Query: 369 AIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYM 428 + DA + W+ GVDG ++ EN + F + KG ++D + Sbjct: 344 KVKDALEFWLQAGVDGFQV----------RDIENLKDASSFLAEWQNIT--KGFSEDRLL 391 Query: 429 IGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGC--YFAKDILSYQQKYANYRS 486 I S + + +L E + L + +G K +++ +Y N Sbjct: 392 IAGTNSSD------LQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVT---QYLNATG 442 Query: 487 DYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDE 546 + + LS + R + A +L +L T G P YG+E+GL G Sbjct: 443 NRWCSWSLS---QARLLTSF-LPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQP 498 Query: 547 YVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAE 606 MLW +S ++ D A VS N+ TV Q D SLL+++ L+ R+ +L Sbjct: 499 MEAPVMLWDES---SFPDIPGA-VSANM-TVKGQSEDPGSLLSLFRRLSDQRSKERSLLH 553 Query: 607 GNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFG-----------GTAMQLPLTD 655 G+ S + I W NE+ LV+ NFG L Sbjct: 554 GDFHAFSAG----PGLFSYIRHW---DQNERFLVVLNFGDVGLSAGLQASDLPASASLPA 606 Query: 656 KIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFK 689 K + +L ++ + + LKL + ++ + Sbjct: 607 KADLLLSTQPGREEGSPLELERLKLEPHEGLLLR 640 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 34/106 (32%), Positives = 54/106 (50%), Gaps = 2/106 (1%) Query: 75 DGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDR 134 G G G+L G+ +LDYL+ L VK L L PIH TD +++P G++ DFD Sbjct: 249 QGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDD-VAQTDLLQIDPNFGSKEDFDS 307 Query: 135 LVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 L+ A + I++ LD N+ G + WF+ + + ++ F Sbjct: 308 LLQSAKKKSIRVILDLTPNYRG-ENSWFSTQVDTVATKVKDALEFW 352 >2BHU-A nrPDB Length = 602 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 38/143 (26%), Positives = 56/143 (39%), Gaps = 14/143 (9%) Query: 25 DDKNITDPAPEPEPP-VEGQWTALTASPDTWDET-----KRAD-ISYQLLLYSFADSDGD 77 D DP P V G+ + W + K AD + Y++ + +F Sbjct: 84 DGVPTPDPYARFLPDGVHGEAEVVDFGTFDWTDADWHGIKLADCVFYEVHVGTFTPE--- 140 Query: 78 GYGDLNGVTQKLDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRL 135 G +KL YL +LGV A+ + P+ GYD + G D L Sbjct: 141 --GTYRAAAEKLPYLKELGVTAIQVMPLAAFDGQRGWGYDGAAFYAPYAPYGRPEDLMAL 198 Query: 136 VTEAHNRGIKIYLDYVMNHTGTA 158 V AH G+ ++LD V NH G + Sbjct: 199 VDAAHRLGLGVFLDVVYNHFGPS 221 Score = 37.8 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 78/236 (33%), Gaps = 33/236 (13%) Query: 324 NAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWI-ARGV 382 N P+ S +YF F + W L+Y E + + A+ W+ Sbjct: 216 NHFGPSGNYLSSYAPSYFTDRFSSAWGMGLDY------AEPHMRRYVTGNARMWLRDYHF 269 Query: 383 DGLRLDAVKHIYHSETS---EENPRFLKMFYEDMNAYYKQKGHTDDFYMI----GEVLSE 435 DGLRLDA ++ + E + + + + D + G + Sbjct: 270 DGLRLDATPYMTDDSETHILTELAQEIHELGGTHLLLAEDHRNLPDLVTVNHLDGIWTDD 329 Query: 436 YDKVA---------PYYKGLPALFE-FSFWYRLEWGINNSTGCYFAKDILSYQQKYANYR 485 + YY G E ++ R W ++ A Sbjct: 330 FHHETRVTLTGEQEGYYAGYRGGAEALAYTIRRGWRYEGQFWAVKGEEHERGHPSDALEA 389 Query: 486 SDYIEATKLSNHDE-------DRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEE 534 +++ + NHD+ +R G + + + AAA+LLT P ++ G+E Sbjct: 390 PNFVYC--IQNHDQIGNRPLGERLHQSDGVTLHEYRGAAALLLTLPMTPLLFQGQE 443 >2DH2-A nrPDB Length = 424 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 125/334 (37%), Gaps = 50/334 (14%) Query: 369 AIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYM 428 + DA + W+ GVDG ++ EN + F + KG ++D + Sbjct: 123 KVKDALEFWLQAGVDGFQV----------RDIENLKDASSFLAEWQNIT--KGFSEDRLL 170 Query: 429 IGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGC--YFAKDILSYQQKYANYRS 486 I S + + +L E + L + +G K +++ +Y N Sbjct: 171 IAGTNSSD------LQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVT---QYLNATG 221 Query: 487 DYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDE 546 + + LS + R + A +L +L T G P YG+E+GL G Sbjct: 222 NRWCSWSLS---QARLLTSF-LPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQP 277 Query: 547 YVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAE 606 MLW +S ++ D A VS N+ TV Q D SLL+++ L+ R+ +L Sbjct: 278 MEAPVMLWDES---SFPDIPGA-VSANM-TVKGQSEDPGSLLSLFRRLSDQRSKERSLLH 332 Query: 607 GNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFG-----------GTAMQLPLTD 655 G+ S + I W NE+ LV+ NFG L Sbjct: 333 GDFHAFSAG----PGLFSYIRHW---DQNERFLVVLNFGDVGLSAGLQASDLPASASLPA 385 Query: 656 KIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFK 689 K + +L ++ + + LKL + ++ + Sbjct: 386 KADLLLSTQPGREEGSPLELERLKLEPHEGLLLR 419 Score = 99.4 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 34/106 (32%), Positives = 54/106 (50%), Gaps = 2/106 (1%) Query: 75 DGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDR 134 G G G+L G+ +LDYL+ L VK L L PIH TD +++P G++ DFD Sbjct: 28 QGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDD-VAQTDLLQIDPNFGSKEDFDS 86 Query: 135 LVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 L+ A + I++ LD N+ G + WF+ + + ++ F Sbjct: 87 LLQSAKKKSIRVILDLTPNYRG-ENSWFSTQVDTVATKVKDALEFW 131 >3UEQ-A nrPDB Length = 632 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 15/143 (10%) Query: 46 ALTASPDTWDETKR-ADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSP 104 A +PD K+ + Y + FA GDL G+ K+ Y +LG+ L L P Sbjct: 89 ARENNPDWILSNKQVGGVCY---VDLFA-------GDLKGLKDKIPYFQELGLTYLHLMP 138 Query: 105 IHPCM---SYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPW 161 + C S GY V+ Y VNP LGT D ++ H GI +D++ NHT H W Sbjct: 139 LFKCPEGKSDGGYAVSSYRDVNPALGTIGDLREVIAALHEAGISAVVDFIFNHTSNEHEW 198 Query: 162 FTEASSSSESPYRNYYSFSEDPK 184 + ++ + + N+Y D + Sbjct: 199 -AQRCAAGDPLFDNFYYIFPDRR 220 Score = 74.8 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 65/409 (15%), Positives = 110/409 (26%), Gaps = 93/409 (22%) Query: 346 CTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHS-ETSEENPR 404 + DLNY ++A+A GVD LR+DAV I+ TS EN Sbjct: 254 FNSFQWDLNY------SNPWVFRAMAGEMLFLANLGVDILRMDAVAFIWKQMGTSCENLP 307 Query: 405 FLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEF-SFWYRLEWGIN 463 NA + + E + D+V Y + L W Sbjct: 308 QAHALIRAFNAVMRIAA--PAVFFKSEAIVHPDQVVQYIGQDECQIGYNPLQMALLWNTL 365 Query: 464 NSTGCYFAKDILSYQQKYANYRS--------------------------DYIEATKLSNH 497 + L+Y+ + + Y L+ Sbjct: 366 ATREVNLLHQALTYRHNLPEHTAWVNYVRSHDDIGWTFADEDAAYLGISGYDHRQFLNRF 425 Query: 498 DEDRTSSKLGKSA-------------------------------DKCKLAAAVLLTSAGH 526 +R + D+ KL ++ L++ G Sbjct: 426 FVNRFDGSFARGVPFQYNPSTGDCRVSGTAAALVGLAQDDPHAVDRIKLLYSIALSTGGL 485 Query: 527 PYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHS 586 P IY G+E+G D W + D A + + + Q+ D + Sbjct: 486 PLIYLGDEVGTLNDDD-----------WSQDSNKS-DDSRWAHRPRYNEALYAQRNDPST 533 Query: 587 ----LLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIH 642 + + +R + P G + + N K I + N LL Sbjct: 534 AAGQIYQDLRHMIAVRQSNPRFDGGRLVTFNTNN-------KHIIGYIR---NNALLAFG 583 Query: 643 NFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLG 691 NF + + T S + L L Y + ++ Sbjct: 584 NFSEYPQTVTAHTLQAMPFKAHDLIGGKTVSLNQDLTLQPYQVMWLEIA 632 >3CZE-A nrPDB Length = 644 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 11/123 (8%) Query: 64 YQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM---SYHGYDVTDYT 120 Y FA G L GV +++ YL +LGV+ L L P + G+ V+DY Sbjct: 94 YSAYADRFA-------GTLQGVAERVPYLQELGVRYLHLLPFLRARAGDNDGGFAVSDYG 146 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFS 180 +V P LG+ D L + GI + D+V+NHT H W +A+ + ++ Y +YY Sbjct: 147 QVEPSLGSNDDLVALTSRLREAGISLCADFVLNHTADDHAW-AQAARAGDARYLDYYHHF 205 Query: 181 EDP 183 D Sbjct: 206 ADR 208 Score = 58.6 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 53/177 (29%), Gaps = 22/177 (12%) Query: 512 KCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVS 571 + L A+ L G P IY G+EL + D+ R + Sbjct: 473 RLVLLYAIALAMPGVPLIYMGDELAMVNDPGYRDDPHRQ------------HEGRWLHRP 520 Query: 572 KNVKTVADQQADTHSLLNI-YFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 +A Q+ D SL Y L L AL G + D + + A Sbjct: 521 AMDWQLAAQRHDAKSLSGTVYRRLRGLIRQRAAL--GALAADQALASIALNDPR-VFALT 577 Query: 631 MTKDNEKLLVIHNFGGTAMQLPLT---DKIEKVLFVNGETQQNTDSDSYTLKLGGYA 684 + + +HNF + + L +L ++ ++ L Y Sbjct: 578 R---GDSFIALHNFSDQLLDVELAAIGVDGWTLLAIDDAIGGAAARGDGSIVLPPYG 631 Score = 30.1 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 28/74 (37%), Gaps = 9/74 (12%) Query: 328 PANIMF-DSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 P N + D + + + W DLN+ + +A A GV+ R Sbjct: 227 PGNFTWVDDTAQWMWTTFYPYQW--DLNW------SNPAVFGDMALAMLRLANLGVEAFR 278 Query: 387 LDAVKHIYHSETSE 400 LD+ +++ ++ Sbjct: 279 LDSTAYLWKRIGTD 292 >2WPG-A nrPDB Length = 637 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 38/129 (29%), Positives = 61/129 (47%), Gaps = 11/129 (8%) Query: 58 KRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCM---SYHGY 114 ++ + Y + FA G L GV +++ YL +LGV+ L L P + G+ Sbjct: 89 QQDMLGYSAYVDRFA-------GTLRGVAERVPYLQELGVRYLHLLPFLRARAGDNDGGF 141 Query: 115 DVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYR 174 V+DY +V P LG+ D L I + D+V+NHT H W +A+ + ++ Y Sbjct: 142 AVSDYGQVEPALGSNDDLVALTARLRAANISLCADFVLNHTADDHAW-AQAARAGDTRYL 200 Query: 175 NYYSFSEDP 183 +YY D Sbjct: 201 DYYHHFADR 209 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 39/175 (22%), Positives = 55/175 (31%), Gaps = 26/175 (14%) Query: 515 LAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNV 574 L AV L G P IY G+EL L D+ R + Sbjct: 477 LLYAVSLAMPGVPLIYMGDELALPNDTAYLDDAQRR------------HEGRWLHRPAMA 524 Query: 575 KTVADQQADTHSLLNIY----FSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 +A Q+ D +L +L RLR PALA + S + A Sbjct: 525 WELAAQRHDASTLAGTVYTRLRALIRLRAGLPALA------ATQSLGSVALGDARLFALT 578 Query: 631 MTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYT-LKLGGYA 684 + L +HNF + + LT + V + +T L L Y Sbjct: 579 R---GDSFLAVHNFSDVPLPVDLTQTGHALWAVLDTDGTGDAPEPHTELLLPAYG 630 Score = 33.9 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 30/74 (40%), Gaps = 9/74 (12%) Query: 328 PANIMF-DSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 P N + D + + + + W DLN+ GE A+ + A GV+ R Sbjct: 228 PGNFTWVDETRQWMWTTFYPYQW--DLNWSNPAVFGEMAL--AMLELAN----LGVEAFR 279 Query: 387 LDAVKHIYHSETSE 400 LD+ +++ + Sbjct: 280 LDSTAYLWKRPGTN 293 >2TAA-A nrPDB Length = 478 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 43/170 (25%), Positives = 61/170 (35%), Gaps = 34/170 (20%) Query: 49 ASPDTWDETKRADISYQLLLYSFADSDGDGY------------GDLNGVTQKLDYLNQLG 96 A+P W R+ Y LL FA +DG G G+ KLDY+ +G Sbjct: 1 ATPADW----RSQSIYFLLTDRFARTDGSTTATCNTADQKYCGGTWQGIIDKLDYIQGMG 56 Query: 97 VKALWLSPIHP--------CMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL 148 A+W++P+ +Y GY TD +N GT D L + H RG+ + + Sbjct: 57 FTAIWITPVTAQLPQDCAYGDAYTGYWQTDIYSLNENYGTADDLKALSSALHERGMYLMV 116 Query: 149 DYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQE 198 D V NH G +Y F D + E Sbjct: 117 DVVANHMGYD----------GAGSSVDYSVFKPFSSQDYFHPFCFIQNYE 156 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 48/223 (21%), Positives = 76/223 (34%), Gaps = 37/223 (16%) Query: 338 ITYFHSHFCTDWFADLNYGPVDQAGES----PAYQAIADAAKG-WIA--------RGVDG 384 YFH + D G++ P D K W +DG Sbjct: 143 QDYFHPFCFIQNYEDQTQVEDCWLGDNTVSLPDLDTTKDVVKNEWYDWVGSLVSNYSIDG 202 Query: 385 LRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVA-PYY 443 LR+D VKH+ K F+ N Y IGEVL PY Sbjct: 203 LRIDTVKHV------------QKDFWPGYNKA-------AGVYCIGEVLDGDPAYTCPYQ 243 Query: 444 KGLPALFEFSFWYRLEWGINNSTG-CYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRT 502 + + + +Y L +++G ++++ + + + T + NHD R Sbjct: 244 NVMDGVLNYPIYYPLLNAFKSTSGSMDDLYNMINTVKS--DCPDSTLLGTFVENHDNPRF 301 Query: 503 SSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGD 545 +S K AA ++ + G P IY G+E G D + Sbjct: 302 AS-YTNDIALAKNVAAFIILNDGLPIIYAGQEQHYAGGNDPAN 343 >4AYS-A nrPDB Length = 648 Score = 118 bits (296), Expect = 8e-27, Method: Composition-based stats. Identities = 45/125 (36%), Positives = 59/125 (47%), Gaps = 11/125 (8%) Query: 62 ISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIH---PCMSYHGYDVTD 118 + Y + FA G L GV ++L+YL LGV L L P+ + GY V D Sbjct: 92 VGYVAYVDRFA-------GTLRGVGERLEYLEGLGVTYLHLLPLLRPRDGENDGGYAVQD 144 Query: 119 YTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYS 178 Y V P LGT D L E RGI + LD V+NH H W A ++ E+ YR+Y+ Sbjct: 145 YRSVRPDLGTIDDLSALARELRGRGISLVLDLVLNHVAEEHEWAVRA-TAGEAAYRDYFH 203 Query: 179 FSEDP 183 D Sbjct: 204 IFPDR 208 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 32/206 (15%), Positives = 58/206 (28%), Gaps = 32/206 (15%) Query: 492 TKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKD--------- 542 L D +R + + L AV+L G P +Y G+EL L D Sbjct: 458 LALETGDAERV----NDALARLLLLHAVMLGFGGVPLLYMGDELALLNDTDFAAVPAHAA 513 Query: 543 NGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYP 602 + R M W + T V+ + + L +R P Sbjct: 514 DNRWVHRPQMDWELVASAQADAATGQPVTPAGR-----------MFAGLRHLLAVRRRTP 562 Query: 603 ALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPL-TDKIE-KV 660 L + + + + LL ++NF + P + + Sbjct: 563 HL-HASTESRPLPSPD-----PCVLLLRREHPTGVLLQVYNFSEHHITFPTWPLQEQLGA 616 Query: 661 LFVNGETQQNTDSDSYTLKLGGYASV 686 + + + L L Y ++ Sbjct: 617 VAHDLLGESQFHLGGPDLALEPYRAL 642 Score = 35.9 bits (81), Expect = 0.055, Method: Composition-based stats. Identities = 19/157 (12%), Positives = 49/157 (31%), Gaps = 15/157 (9%) Query: 328 PANIMFDSQQITY-FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLR 386 P N ++ + + + + + W D+N+G ++ D RGV+ R Sbjct: 227 PGNFTWNGEAGGWVWTTFNRSQW--DVNWG------NPAVFREYLDLILTLANRGVEVFR 278 Query: 387 LDAVKHIYHSETS-----EENPRFLKMFYEDMNAYYKQKGHTDDFYM-IGEVLSEYDKVA 440 LDA+ ++ + E R + + G+++ Sbjct: 279 LDAIAFLWKRLGTDCQNQPEVHRLTHALRAATRIVAPAVAFKAEAIVAPGDLIHYLGSRD 338 Query: 441 PYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSY 477 + + + S +L + + + ++ Sbjct: 339 HHGRVSDMAYHNSLMVQLWSSLASRDTRLLTAALAAF 375 >3DHU-A nrPDB Length = 449 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 41/149 (27%), Positives = 67/149 (44%), Gaps = 23/149 (15%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHG----- 113 R ++ Y + + +++++ G+ GVT L + LG LWL PI+P + Sbjct: 11 RNEMIYSVFVRNYSEA-----GNFAGVTADLQRIKDLGTDILWLLPINPIGEVNRKGTLG 65 Query: 114 --YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGT------AHP-WFTE 164 Y + DY +NP+ GT +DF L AH G+K+ LD V NHT HP WF Sbjct: 66 SPYAIKDYRGINPEYGTLADFKALTDRAHELGMKVMLDIVYNHTSPDSVLATEHPEWFYH 125 Query: 165 ASSSS-ESPYRNYYSFSEDPKTDIAAGKI 192 + + + +S+ D ++ Sbjct: 126 DADGQLTNKVGD---WSDVKDLDYGHHEL 151 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 73/219 (33%), Gaps = 20/219 (9%) Query: 324 NAGNPANIMFDSQQITYFHSHFC--TDWFADLNYGPVDQAGESPAYQAIADAAKGWIARG 381 N +P +++ ++H T+ D + G +Q D W Sbjct: 107 NHTSPDSVLATEHPEWFYHDADGQLTNKVGDWSDVKDLDYGHHELWQYQIDTLLYWSQF- 165 Query: 382 VDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIG---EVLSEYD- 437 VDG R D + F + +NA Y + + G E+ S+ Sbjct: 166 VDGYRCDVAPLVPLD--------FWLEARKQVNAKYPETLWLAESAGSGFIEELRSQGYT 217 Query: 438 --KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS 495 + Y+ +++ + + + D+L Q A + +Y++ L Sbjct: 218 GLSDSELYQAFDMTYDYDVFGDFKDYWQGRSTVERYVDLLQRQD--ATFPGNYVKMRFLE 275 Query: 496 NHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEE 534 NHD R S + A+ + G P IY G+E Sbjct: 276 NHDNARMMSLMHSKAEAVN-NLTWIFMQRGIPLIYNGQE 313 >5ZCR-A nrPDB Length = 728 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 45/148 (30%), Positives = 67/148 (45%), Gaps = 13/148 (8%) Query: 81 DLNGVTQKLDYLNQLGVKALWLSPIHPC--MSYHGYDVTDYTKVNPQLGTESDFDRLVTE 138 + LDY +LGV L+LSPI S HGYDV D++++N +LG E + +LV E Sbjct: 15 TFYDTIENLDYFKELGVSHLYLSPILKARPGSTHGYDVVDHSEINEELGGEEGYFKLVKE 74 Query: 139 AHNRGIKIYLDYVMNHTGTAHP-W--FTEASSSSESPYRNYYSFSEDPKTDIA--AGKIA 193 A +RG++I D V NH H W S S Y NY+ +D K + ++ Sbjct: 75 AKSRGLEIIQDIVPNHMAVHHTNWRLMDLLKSWKNSKYYNYFDHYDDDKIILPILEDELD 134 Query: 194 MITQEGAAGYNAAEW------FQVSDET 215 + +G ++DE Sbjct: 135 TVIDKGLIKLQKDNIEYRGLVLPINDEG 162 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 24/197 (12%), Positives = 58/197 (29%), Gaps = 36/197 (18%) Query: 428 MIGEVLSEYDKVAPYYK-----GLPALFEFSFWYRLEWGINNSTGCYFAKD----ILSYQ 478 ++ E+ E+++ Y+ + E+ F+ L K+ ++ Sbjct: 473 VLSEIPKEWEERVKYWHDLLRPNIDKNDEYRFYQTLVGSYEGFDNKERIKNHIIKVIREA 532 Query: 479 QKYANYRSDYIEAT-----KLSNH-DEDRTSSKLGKSADKC--------KLAAAVLLTSA 524 + + + + +E + + + K +A + S Sbjct: 533 KVHTTWENPNLEYEKKVLGFIDEVFENSSFRNDFDNFEKKIVYFGYMKSLVATTLKFLSP 592 Query: 525 GHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADT 584 G P IY G E+ + D + + + N+ + +D Sbjct: 593 GVPDIYQGTEVWRFLLTDPDNRMA-------------VDFRKLRELLNNLTEKNLELSDP 639 Query: 585 HSLLNIYFSLTRLRNTY 601 + + L +LR Y Sbjct: 640 RTKMLYVKKLLQLRREY 656 >3EDF-A nrPDB Length = 601 Score = 114 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 40/141 (28%), Positives = 62/141 (43%), Gaps = 31/141 (21%) Query: 60 ADISYQLLLYSFADSDGDGYGDLNGV--------------------TQKLDYLNQLGVKA 99 D YQ++ FA+ D ++ G+ LDY+ LG Sbjct: 106 GDAIYQIMPDRFANGDPSND-NVAGMREQADRRHGGGRHGGDIRGTIDHLDYIAGLGFTQ 164 Query: 100 LWLSPI----HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT 155 LW +P+ SYHGY TD+ +++P+ G+ DF RL TEA RG+ + D V++H Sbjct: 165 LWPTPLVENDAAAYSYHGYAATDHYRIDPRYGSNEDFVRLSTEARKRGMGLIQDVVLSHI 224 Query: 156 GTAHPWFTEASSSSESPYRNY 176 G H W + P ++ Sbjct: 225 GKHHWWMKDL------PTPDW 239 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 55/324 (16%), Positives = 99/324 (30%), Gaps = 56/324 (17%) Query: 346 CTDWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPR 404 + DLN A + WI G+ GLR+D + + Sbjct: 274 FVEGMPDLNQTNPLVA------NYLIQNNIWWIEYAGLSGLRIDTYGY--------SDGA 319 Query: 405 FLKMFYEDMNAYYKQKGHTDDFYMIG-EVLSEYDKVAPYYKG----------LPALFEFS 453 FL + + A Y + M+G E + VA + +G LP+L +F Sbjct: 320 FLTEYTRRLMAEYPRLN------MVGQEWSTRVPVVARWQRGKANFDGYTSHLPSLMDFP 373 Query: 454 FWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKC 513 + ++ + ++ Y NHD R S G+ D+ Sbjct: 374 LVDAMRNALSKTGEENGLNEVYETLSLDYLYPEPQNLVLFGGNHDMARMFSAAGEDFDRW 433 Query: 514 KLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYV-RSPML--WGDSYTTNYTDKTDATV 570 ++ L+T P Y G+E+ + T D+ R W ++ Sbjct: 434 RMNLVFLMTMPRIPQFYSGDEILMTSTVKGRDDASYRRDFPGGWAGDKANAFSGAG---- 489 Query: 571 SKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWY 630 + QQ L+ L R P + G + + ++ Sbjct: 490 ------LTSQQRAAQDLV---RKLANWRKNQPVIHNGRLMHFGPEENTWV--------YF 532 Query: 631 MTKDNEKLLVIHNFGGTAMQLPLT 654 +++++V N M LP Sbjct: 533 RYNKDKRIMVAMNNNDKPMTLPTA 556 >5H05-A nrPDB Length = 640 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 23/115 (20%) Query: 63 SYQLLLYSFADSDG-----------DGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSY 111 YQ+++ SF + D GDL G+ LDY+ LG+ A+WL+PI + Sbjct: 16 IYQVMVESFVNGDDAIGHGTGYGTSHHKGDLQGIIDSLDYIESLGMNAIWLTPIFDSIPV 75 Query: 112 HGYD------------VTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNH 154 G D ++Y V+P+ GT LV +AH +G+ ++ D V H Sbjct: 76 EGQDHWADRLDATGYFTSNYFAVDPRFGTMEQAKELVEKAHEKGLYVFFDGVFGH 130 Score = 86.3 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 61/361 (16%), Positives = 110/361 (30%), Gaps = 40/361 (11%) Query: 353 LNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYE 411 L G + + + A WI +DG RLD + + + Sbjct: 143 LPVGENNPVSYPESLAFYQEVATFWIEELKIDGWRLDQAYQVPTEAWTAIRASVDEASKS 202 Query: 412 DMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY---KGLPAL---FEFSFWYRLEWGINNS 465 K + YM+ ++ + + + +G PAL F+F YR+ + Sbjct: 203 VTYVNSKGEAVNPLGYMVAQIWNNENYIKETGYGAEGEPALCSAFDFPVRYRVVETFAAN 262 Query: 466 TGCYFAKDILSYQQKYANYRSDYI----EATKLSNHDEDRTSSKLGKSA----------D 511 K + + N Y L NHD R L + + Sbjct: 263 ENGIGNKG-GKWLDEGMNLHRLYPSHAQPNLMLGNHDLVRFGDLLQRGNIASPEQAEYWE 321 Query: 512 KCKLAAAVLLTSAGHPYIYYGEELG--LYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDAT 569 + K A + +G +YYGEE+G L G ++ ++ +T A Sbjct: 322 RHKAALSFQAAYSGPITLYYGEEIGDELEGYAQKVEQDCAV-----QGLCDDHVARTSAN 376 Query: 570 VSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAW 629 + + ++Q D L LR +PAL+ G T + Sbjct: 377 IDGLTVNLNEKQRDLKQ---YVSQLMTLRAAHPALSRGERTNIVANETVYIDHKQA---- 429 Query: 630 YMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTD--SDSYTLKLGGYASVV 687 D +V ++L +D V+ T + + Y + L + + Sbjct: 430 --DDDALIYMVSTTADQDTVELKASDIASDGQLVDLLTGKVHSAINGEYQISLAPFEAKF 487 Query: 688 F 688 Sbjct: 488 L 488 >4U33-A nrPDB Length = 723 Score = 112 bits (280), Expect = 6e-25, Method: Composition-based stats. Identities = 41/179 (22%), Positives = 63/179 (35%), Gaps = 43/179 (24%) Query: 53 TWDETKRADI--SYQLLLYSFADSDGDG---YGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 W + A Y++ S D DG +G +L + +G ++L PIHP Sbjct: 244 VWVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHP 303 Query: 108 CMSYH---------------------GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 H G D + V+P LGT DFD V+ A + G+++ Sbjct: 304 IGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEV 363 Query: 147 YLDYVMNHTGTAHPWFTEASSS-----------SESPYRNY-----YSFSEDPKTDIAA 189 LD + HPW E +E+P + Y +F DP+ Sbjct: 364 ALDLALQ-CAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDE 421 Score = 38.2 bits (87), Expect = 0.014, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 67/276 (24%), Gaps = 51/276 (18%) Query: 353 LNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 LN+ + Y + + W+ GV R+D + P F Sbjct: 409 LNFDNDPEG----LYDEVLRVVQHWVNHGVKFFRVDNPH--------TKPPNFWAWLIAQ 456 Query: 413 MNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAK 472 + K D + E + A Y F S+ Y W F Sbjct: 457 V------KTVDPDVLFLSEAFT---PPARQYGLAKLGFTQSYSY-FTWRTTKWELTEFGN 506 Query: 473 DILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPY--IY 530 I + A+YR + G + A + P +Y Sbjct: 507 QI----AELADYRRPNLFVNTPD--ILHAVLQHNGPGMFAIRAVLAATM----SPAWGMY 556 Query: 531 YGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNI 590 G EL + + A SL Sbjct: 557 CGYEL----------------FEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQPF 600 Query: 591 YFSLTRLRNTYPALAE-GNMTKHSVYNESQEKDYKP 625 L +R +PA + + H V N++ K Sbjct: 601 ITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKF 636 >2AAA-A nrPDB Length = 484 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 34/122 (27%), Positives = 47/122 (38%), Gaps = 20/122 (16%) Query: 57 TKRADISYQLLLYSFADSDGDGY------------GDLNGVTQKLDYLNQLGVKALWLSP 104 + R Y LL F +D G G+ LDY+ +G A+W+SP Sbjct: 5 SWRTQSIYFLLTDRFGRTDNSTTATCNTGNEIYCGGSWQGIIDHLDYIEGMGFTAIWISP 64 Query: 105 I--------HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTG 156 I +YHGY VN GT + L H RG+ + +D V +H G Sbjct: 65 ITEQLPQDTADGEAYHGYWQQKIYDVNSNFGTADNLKSLSDALHARGMYLMVDVVPDHMG 124 Query: 157 TA 158 A Sbjct: 125 YA 126 Score = 62.4 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 53/297 (17%), Positives = 95/297 (31%), Gaps = 58/297 (19%) Query: 382 VDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVA- 440 VDGLR+D+V + ++ Y +GE+ + Sbjct: 200 VDGLRIDSVLEVQPD-------------------FFPGYNKASGVYCVGEIDNGNPASDC 240 Query: 441 PYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED 500 PY K L + + +++L + +S+G + + ++ + + NHD Sbjct: 241 PYQKVLDGVLNYPIYWQLLYAFESSSGSI-SNLYNMIKSVASDCSDPTLLGNFIENHDNP 299 Query: 501 RTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTT 560 R + K + K + + S G P +Y GEE G K + W Y T Sbjct: 300 RFA-KYTSDYSQAKNVLSYIFLSDGIPIVYAGEEQHYAGGKVPYNREA----TWLSGYDT 354 Query: 561 NYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQE 620 + T + N L + + N++ Sbjct: 355 SAELYTWI-----------------ATTNAIRKLA---------IAADSAYITYANDAFY 388 Query: 621 KDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYT 677 D IA T ++ + V+ N G + LT L +G T ++YT Sbjct: 389 TDSNTIAMAKGTSGSQVITVLSNKGSSGSSYTLT------LSGSGYTSGTKLIEAYT 439 >5CIM-A nrPDB Length = 698 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 41/173 (23%), Positives = 63/173 (36%), Gaps = 43/173 (24%) Query: 53 TWDETKRADI--SYQLLLYSFADSDGDG---YGDLNGVTQKLDYLNQLGVKALWLSPIHP 107 W + A Y++ S D +G +G + L + ++G ++L PIHP Sbjct: 219 VWVDRPEARFSSWYEMFPRSTGGWDAEGRPVHGTFATAAEALPRIARMGFDVVYLPPIHP 278 Query: 108 CMSYH---------------------GYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 H G D + V+PQLGT DFD V A + G+++ Sbjct: 279 IGKVHRKGRNNSVTAAPGDVGSPWAIGSDEGGHDAVHPQLGTIEDFDEFVASARDLGLEV 338 Query: 147 YLDYVMNHTGTAHPWFTEASSS-----------SESPYRNY-----YSFSEDP 183 LD + HPW E +E+P + Y +F DP Sbjct: 339 ALDLALQ-CAPDHPWAREHPEWFTVLPDGSIAYAENPPKKYQDIYPLNFDNDP 390 Score = 45.1 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 82/299 (27%), Gaps = 64/299 (21%) Query: 353 LNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYED 412 LN+ YQ + + WI+ GV+ R+D + P F Sbjct: 384 LNFDNDPAG----IYQEVLRVVRFWISHGVNIFRVDNPH--------TKPPNFWAWLIGQ 431 Query: 413 MNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYK-GLPALFEFSFWYRLEWGINNSTGCYFA 471 + K D + E + ++ K G + + W +W Sbjct: 432 I------KNENPDVLFLSEAFTRPARLYGLAKLGFTQSYTYFTWRTSKW----------- 474 Query: 472 KDILSYQQKYANYRSDYIEATKLSNHDE-DRTSSKLGKSADKCKLAAAVLLTSAGHPY-- 528 ++ + Q+ A ++ D + G + A + P Sbjct: 475 -ELTEFGQEIAAKADIARPNLFVNTPDILHESLQHGGPGMFAIRAVLAATMG----PAWG 529 Query: 529 IYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLL 588 +Y G EL G E + A SL Sbjct: 530 VYSGYELFENQPVRPGSEE----------------YLNSEKYELRPRDFESALARGESLE 573 Query: 589 NIYFSLTRLRNTYPALAE-GNMTKHSVYNESQEKDYKPIAAWYMTK--DNEKLLVIHNF 644 L +R +PAL E + H V N++ + A+ + +LV+ Sbjct: 574 PFLTRLNEIRRLHPALRELRTIRFHHVDNDA-------LLAYSKFDPGTGDTVLVVVTL 625 >1IV8-A nrPDB Length = 720 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 47/179 (26%), Positives = 68/179 (37%), Gaps = 27/179 (15%) Query: 78 GYGDLNGVTQKLDYLNQLGVKALWLSPIHPC--MSYHGYDVTDYTKVNPQLGTESDFDRL 135 +GD V L Y LGV L+LSP+ S HGYDV D++++N +LG E ++ RL Sbjct: 15 NFGD---VIDNLWYFKDLGVSHLYLSPVLMASPGSNHGYDVIDHSRINDELGGEKEYRRL 71 Query: 136 VTEAHNRGIKIYLDYVMNHTGTAH-PW--FTEASSSSESPYRNYYSFSEDPK-------- 184 + AH G+ I D V NH W +S Y Y+ F + Sbjct: 72 IETAHTIGLGIIQDIVPNHMAVNSLNWRLMDVLKMGKKSKYYTYFDFFPEDDKIRLPILG 131 Query: 185 ------TDIAAGKIAMITQEGAAGYNAAEWFQVSDETAAVKGLLKFT----LDWSNAPS 233 KI E Y +++ + L+ + W N PS Sbjct: 132 EDLDTVISKGLLKIVKDGDEYFLEY-FKWKLPLTEVGNDIYDTLQKQNYTLMSWKNPPS 189 Score = 35.9 bits (81), Expect = 0.066, Method: Composition-based stats. Identities = 51/276 (18%), Positives = 90/276 (32%), Gaps = 27/276 (9%) Query: 400 EENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLE 459 E P K E+ ++ K +D Y +VL V +Y+G F F R++ Sbjct: 458 SEFPEEWKNKVEEWHSIINPKVSRNDEYRYYQVL-----VGSFYEG----FSNDFKERIK 508 Query: 460 WGINNSTGCYFAKDILSYQQKYANYR-SDYIEATKLSNHDEDRTSSKLGKSADKCKL--- 515 + S Q K R + +E T N D ++ K + + Sbjct: 509 QHMIKSVREAKINTSWRNQNKEYENRVMELVEETFT-NKDFIKSFMKFESKIRRIGMIKS 567 Query: 516 --AAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKN 573 A+ + SAG P Y G E+ Y D + R P+ + + K K Sbjct: 568 LSLVALKIMSAGIPDFYQGTEIWRYLLTDPDN---RVPVDFKKLHEILEKSK------KF 618 Query: 574 VKTVADQQADTHSLLNIYFSLTRLRNTYPA-LAEGNMTKHSVYNES-QEKDYKPIAAWYM 631 K + + D + + + L LR +G + + I Sbjct: 619 EKNMLESMDDGRIKMYLTYKLLSLRKQLAEDFLKGEYKGLDLEEGLCGFIRFNKILVIIK 678 Query: 632 TKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGET 667 TK + + G + ++I+K + +N Sbjct: 679 TKGSVNYKLKLEEGAIYTDVLTGEEIKKEVQINELP 714 Score = 35.5 bits (80), Expect = 0.076, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 73/208 (35%), Gaps = 33/208 (15%) Query: 322 LTNAGNPANIMFDS-QQITY----FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG 376 LT GN ++D+ Q+ Y + + F D+N + +Q Sbjct: 163 LTEVGND---IYDTLQKQNYTLMSWKNPPSYRRFFDVNTLIGVNVEKDHVFQESHSKI-- 217 Query: 377 WIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDD-FYMIGE---V 432 + VDG R+D + +Y E + D+ + K K + E + Sbjct: 218 -LDLDVDGYRIDHIDGLYDPE----------KYINDLRSIIKNKIIIVEKILGFQEELKL 266 Query: 433 LSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEAT 492 S+ + LF F+ I +S F + +S + ++ I+ Sbjct: 267 NSDGTTGYDFLNYSNLLFNFN------QEIMDSIYENFTAEKISISESIKKIKAQIIDEL 320 Query: 493 KLSNHDEDRTSSKLGKSADKCKLAAAVL 520 +++ R +S+LG S D + + + Sbjct: 321 F--SYEVKRLASQLGISYDILRDYLSCI 346 >4GKL-A nrPDB Length = 422 Score = 105 bits (263), Expect = 6e-23, Method: Composition-based stats. Identities = 35/148 (23%), Positives = 63/148 (42%), Gaps = 19/148 (12%) Query: 59 RADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHG----- 113 + I Y+ ++ G + + L+ L +G+ +WL PIHP Sbjct: 4 KNLIIYEAFARAYPGEKGKK---FLSLEKDLERLKGMGINTVWLMPIHPTGVEGRKGTLG 60 Query: 114 --YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA------HP-WFTE 164 Y + DY +++ +GT+ DF + V AH + + +D V+NH HP WF Sbjct: 61 SPYAIRDYYEIDLLIGTKGDFKKFVKRAHELNMYVLMDMVLNHAAVDNVLVKKHPEWFLR 120 Query: 165 ASSSSESPYRNYYSFSEDPKTDIAAGKI 192 + +P R +S+ D + G++ Sbjct: 121 DENG--NPTRKVPDWSDVVDFDYSNGEL 146 Score = 96.0 bits (237), Expect = 5e-20, Method: Composition-based stats. Identities = 54/337 (16%), Positives = 102/337 (30%), Gaps = 65/337 (19%) Query: 347 TDWFADLNYGPVDQAGESPAYQAIADAAKGWIA-RGVDGLRLDAVKHIYHSETSEENPRF 405 T D + + + + + W+ VDG R D + F Sbjct: 127 TRKVPDWSDVVDFDYSNGELREYMINMMRYWVEEFDVDGFRCDVAGLVPLD--------F 178 Query: 406 LKMFYEDMNAYYKQKG--HTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGIN 463 ++++ + T D YM Y+ +++ +YR I Sbjct: 179 WLQARKNLDPVKRLIWISETHDPYM--------------YQAFDITYDYDGYYRFRDFIE 224 Query: 464 NSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTS 523 D L Q Y YI+ L NHD+ R + L S + A L T Sbjct: 225 GKNSLREYIDFLRMQDHM--YPRGYIKMRFLENHDQPRVAKFL--SRESLMHWIAFLFTV 280 Query: 524 AGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQAD 583 G P ++ G+E L D +EY P+ + Sbjct: 281 KGVPLVHNGQEYALKEDLDIFNEYT-LPIP----------------------------GE 311 Query: 584 THSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 + + +++ L R + G M + + + ++ N +L + N Sbjct: 312 ENEIFSLHRKLAHYRYKTNVFSNGEMIFI------RNDQPERVISYLWRHGNRFILCVLN 365 Query: 644 FGGTAMQLPLT-DKIEKVLFVNGETQQNTDSDSYTLK 679 + L I + + ++ + N D ++K Sbjct: 366 PLLENTSVTLDFSGIWENICIHSKNVFNDDIVRVSVK 402 >2YA2-A nrPDB Length = 708 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 47/211 (22%), Positives = 70/211 (33%), Gaps = 49/211 (23%) Query: 24 SDDKNITDPAPEPEPPVEGQWTA----LTASPDTWDETKRADISYQLLLYSFADSDG--- 76 SDD I D + LT +T+ + Y+ + F Sbjct: 112 SDDSKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAK 171 Query: 77 ---DGYGDLNGVTQKLDYLNQLGVKALWLSPI-----------HPCMSY---------HG 113 +G +KLDYL LGV + L P+ H +S G Sbjct: 172 DLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWG 231 Query: 114 YDVTDYTKVNPQLGT--------ESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEA 165 YD +Y + + ++F L+ E H RG+ LD V NHT + Sbjct: 232 YDPQNYFSLTGMYSSDPKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDLF---- 287 Query: 166 SSSSESPYRNYYSFSE---DPKTDIAAGKIA 193 E NYY F + P+T G++ Sbjct: 288 ----EDLEPNYYHFMDADGTPRTSFGGGRLG 314 Score = 52.4 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 52/398 (13%), Positives = 110/398 (27%), Gaps = 82/398 (20%) Query: 341 FHSHFCTDWFADLNYGPVDQ-AGESPAYQAIADAAKGWIA-RGVDGLRLDAVKHIYHSET 398 ++ D ++G + + D+ K + VDG R D H Sbjct: 294 YYHFMDADGTPRTSFGGGRLGTTHHMTKRLLIDSIKYLVDTYKVDGFRFD--MMGDHDAA 351 Query: 399 SEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEY--DKVAPYYKGL-PALFEFSFW 455 S E AY + + M+GE Y D+ P + Sbjct: 352 SIE------------EAYKAARALNPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTV 399 Query: 456 YRLEWGINNSTGCYFA------------KDILSYQQKYANYRSDY------IEATKLSNH 497 I N+ + +D+ + + +++ ++ H Sbjct: 400 AVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAH 459 Query: 498 DEDRTSSKLGKSA--------------DKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDN 543 D+ + +S + +L ++LT+ G P+I+ G+E G K Sbjct: 460 DDLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRT--KQF 517 Query: 544 GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLN-------------- 589 + R+P+ ++ + + D+ +N Sbjct: 518 RNPAYRTPVAEDKVPNKSHLLRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYP 577 Query: 590 -------IYFSLTRLRNTYPALAEGNMTK-------HSVYNESQEKDYKPIAAWYMTKDN 635 L LR + A ++ +V ++ + + + +T N Sbjct: 578 ENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPN 637 Query: 636 -EKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTD 672 + V N A + L + +N Sbjct: 638 GDIYAVFVNADEKAREFNLGTAFAHLRNAEVLADENQA 675 >4OKD-A nrPDB Length = 840 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 33/129 (25%), Positives = 50/129 (38%), Gaps = 30/129 (23%) Query: 62 ISYQLLLYSFADSDGDGY---GDLNGVTQKLDYLNQLGVKALWLSPIHPC---------- 108 + Y+ + F G G G+ ++LDYL LGV A+ L P+ Sbjct: 225 VIYEAHVRGFTAHASSGVAAPGTYAGMVERLDYLKSLGVNAIELLPVFEFNELEYYSQIP 284 Query: 109 ------MSYHGYDVTDYTKVN-----------PQLGTESDFDRLVTEAHNRGIKIYLDYV 151 ++ GY +Y P + +F +LV E H RGI++ LD V Sbjct: 285 GSDQYRFNFWGYSTVNYFSPMGRFSAAVGQGAPARASCDEFKQLVKECHRRGIEVILDVV 344 Query: 152 MNHTGTAHP 160 NHT + Sbjct: 345 FNHTAEGNE 353 Score = 36.6 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 41/161 (25%), Gaps = 28/161 (17%) Query: 509 SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDA 568 + + LL S G P I G+E YG NG+ T D+ Sbjct: 634 RQRQMRNLTGALLLSCGVPMINMGDE---YGHSKNGNNN---------------TYCHDS 675 Query: 569 TVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNM----TKHSVYNESQEKDY- 623 + N D H L R PAL D+ Sbjct: 676 EL--NYLRWDQLAEDPHGFNRFVRLLIHFRRATPALQRTTFVNDKDIQWHGELPNTPDWT 733 Query: 624 --KPIAAWYMTKD-NEKLLVIHNFGGTAMQLPLTDKIEKVL 661 + A+ + L V N L L +V Sbjct: 734 DTSRLVAFTLHDGKGGGLYVAFNTSHLPKLLQLPKWGGRVW 774 Score = 35.5 bits (80), Expect = 0.092, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 13/37 (35%), Gaps = 1/37 (2%) Query: 356 GPVDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVK 391 G + Q I D K W+ VDG R D Sbjct: 384 GNTLNCNQPVVRQFILDCLKHWVTEYHVDGFRFDLAS 420 >1BF2-A nrPDB Length = 750 Score = 101 bits (252), Expect = 1e-21, Method: Composition-based stats. Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 27/144 (18%) Query: 43 QWTALTASPDTWDETKRADISYQLLLYSFADSD----GDGYGDLNGVTQKLDYLNQLGVK 98 T T + T ++ D+ Y++ + F + D G G K YL LGV Sbjct: 163 PSTQSTGTKPT--RAQKDDVIYEVHVRGFTEQDTSIPAQYRGTYYGAGLKASYLASLGVT 220 Query: 99 ALWLSPIHPCMS--------------YHGYDVTDYTKVNPQL-------GTESDFDRLVT 137 A+ P+ + Y GY +Y + + G ++F +V Sbjct: 221 AVEFLPVQETQNDANDVVPNSDANQNYWGYMTENYFSPDRRYAYNKAAGGPTAEFQAMVQ 280 Query: 138 EAHNRGIKIYLDYVMNHTGTAHPW 161 HN GIK+Y+D V NHT W Sbjct: 281 AFHNAGIKVYMDVVYNHTAEGGTW 304 Score = 38.2 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 51/411 (12%), Positives = 99/411 (24%), Gaps = 66/411 (16%) Query: 339 TYFHSHFCTDWFADLNYGPVDQAGESPAYQAIA-DAAKGWIA-RGVDGLRLDAVKHIYH- 395 TY+ +F D + + Q + D+ W GVDG R D + + Sbjct: 324 TYYELTSGNQYFYDNTGIGANFNTYNTVAQNLIVDSLAYWANTMGVDGFRFDLASVLGNS 383 Query: 396 --------SETSEENPRF----------LKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYD 437 S + N + + + G D + E + Sbjct: 384 CLNGAYTASAPNCPNGGYNFDAADSNVAINRILREFTVRPAAGGSGLDLF--AEPWA-IG 440 Query: 438 KVAPYYKGLP-----ALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANY----RSDY 488 + G P F R S Y +D + + RS + Sbjct: 441 GNSYQLGGFPQGWSEWNGLFRDSLRQAQNELGSMTIYVTQDANDFSGSSNLFQSSGRSPW 500 Query: 489 IEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGL---YGTKDNGD 545 + HD + A + G Y + G+ G + Sbjct: 501 NSINFIDVHDGMTLKDVYSCNGANNSQAWPYGPSDGGTSTNYSWD-QGMSAGTGAAVDQR 559 Query: 546 EYVRSPMLW------GDSYTTNYTDKTDATVSKNVKTVADQQA--------DTHSLLNIY 591 R+ M + + N + D + Sbjct: 560 RAARTGMAFEMLSAGTPLMQGGDEYLRTLQCNNNAYNLDSSANWLTYSWTTDQSNFYTFA 619 Query: 592 FSLTRLRNTYPALA---------------EGNMTKHSVYNESQEKDYKPIAAWYMTKDNE 636 L R +PAL G + + +N + D+ Sbjct: 620 QRLIAFRKAHPALRPSSWYSGSQLTWYQPSGAVADSNYWNNTSNYAIAYAINGPSLGDSN 679 Query: 637 KLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVV 687 + V +N +++ L + + + + T G +++ Sbjct: 680 SIYVAYNGWSSSVTFTLPAPPSGTQWYRVTDTCDWNDGASTFVAPGSETLI 730 >3FAW-A nrPDB Length = 877 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 46/209 (22%), Positives = 72/209 (34%), Gaps = 47/209 (22%) Query: 21 TACSDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFA-DSDGDG- 78 T D K T A P G A + ++ + Y+ + F D DG Sbjct: 231 TVNDDIK--TAKAAFVNPSQLGPQNLSFAKIANFKG-RQDAVIYEAHVRDFTSDQSLDGK 287 Query: 79 ----YGDLNGVTQKLDYLNQLGVKALWLSPIH---------PCMS----------YHGYD 115 G ++KLDYL +LGV + L P+ S GYD Sbjct: 288 LKNQLGTFAAFSEKLDYLQKLGVTHIQLLPVLSYFYVNEMDKSRSTAYTSSDNNYNWGYD 347 Query: 116 VTDYTKVNPQL--------GTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASS 167 Y ++ ++ +L+ + H RG+ + LD V NHT + + Sbjct: 348 PQSYFALSGMYSEKPKDPSARIAELKQLIHDIHKRGMGVILDVVYNHTAKTYLF------ 401 Query: 168 SSESPYRNYYSFSED---PKTDIAAGKIA 193 E NYY F + P+ G++ Sbjct: 402 --EDIEPNYYHFMNEDGSPRESFGGGRLG 428 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 61/421 (14%), Positives = 120/421 (28%), Gaps = 84/421 (19%) Query: 341 FHSHFCTDWFADLNYGPVDQ-AGESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHSET 398 ++ D ++G + + + + D+ K VDG R D H Sbjct: 408 YYHFMNEDGSPRESFGGGRLGTTHAMSRRVLVDSIKYLTSEFKVDGFRFD--MMGDHDAA 465 Query: 399 SEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEY---------DKVAPYYKGLPAL 449 + E AY + K + MIGE + + K + Sbjct: 466 AIEL------------AYKEAKAINPNMIMIGEGWRTFQGDQGKPVKPADQDWMKSTDTV 513 Query: 450 --FEFSFWYRLEWGINNSTGCYFAK----------DILSYQQKYANYRSDYIEATKLSNH 497 F L+ G N F + Q S ++ H Sbjct: 514 GVFSDDIRNSLKSGFPNEGTPAFITGGPQSLQGIFKNIKAQPGNFEADSPGDVVQYIAAH 573 Query: 498 DEDRTSSKLGKSA------------DKCKLAAAVLLTSAGHPYIYYGEELG--------- 536 D + KS + +L ++LTS G +I+ G+E G Sbjct: 574 DNLTLHDVIAKSINKDPKVAEEDIHRRLRLGNVMILTSQGTAFIHSGQEYGRTKRLLNPD 633 Query: 537 -LYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLN-----I 590 + D+ + + Y D D++ + N A + ++ Sbjct: 634 YMTKVSDDKLPNKATLIEAVKEYPYFIHDSYDSSDAINHFDWAAATDNNKHPISTKTQAY 693 Query: 591 YFSLTRLRNTYPALA-------EGNMTKHSVYNESQEKDYKPIAAWYMTKD-NEKLLVIH 642 L LR + A + ++ + + K+ + A+ + V Sbjct: 694 TAGLITLRRSTDAFRKLSKAEIDREVSLITEVGQGDIKEKDLVIAYQTIDSKGDIYAVFV 753 Query: 643 NFGGTAMQLPLTDKIEKVL-----------FVNGETQQNT-DSDSYTLKLGGYASVVFKL 690 N A + L +K + +L + + + +L + ++V K+ Sbjct: 754 NADSKARNVLLGEKYKHLLKGQVIVDADQAGIKPISTPRGVHFEKDSLLIDPLTAIVIKV 813 Query: 691 G 691 G Sbjct: 814 G 814 >4CN6-A nrPDB Length = 695 Score = 93.6 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 37/165 (22%), Positives = 57/165 (34%), Gaps = 40/165 (24%) Query: 63 SYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYH---------- 112 Y+ S + +G ++L + +G ++L PIHP + H Sbjct: 234 WYEFFPRS-EGTPHTPHGTFRTAARRLPAIAAMGFDVVYLPPIHPIGTTHRKGRNNTLSA 292 Query: 113 -GYDV----------TDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPW 161 G DV + ++P LGT DFD VTEA G++I LD+ + HPW Sbjct: 293 TGDDVGVPWAIGSPEGGHDSIHPALGTLDDFDHFVTEAGKLGLEIALDFALQ-CSPDHPW 351 Query: 162 FTEASSSSESPYRNYYSFSED---------PKTDIAAGKIAMITQ 197 + ++ D PK IA Sbjct: 352 VH--------KHPEWFHHRPDGTIAHAENPPKKYQDIYPIAFDAD 388 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 73/279 (26%), Gaps = 61/279 (21%) Query: 373 AAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEV 432 + W+ GV R+D + F + D+N G D + Sbjct: 399 ILRHWMDHGVRIFRVDNPH--------TKPVAFWERVIADIN------GTDPDVIFLAAA 444 Query: 433 LSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEAT 492 + +A L + F + +T + + + A+Y Sbjct: 445 FTRPAMMA-------TLAQIGFQQSYTYFTWRNTKQELTEYLTELSGEAASYMRPN---F 494 Query: 493 KLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDE------ 546 + D + G ++ A + T + IY G EL G E Sbjct: 495 FANTPDILHAYLQHGG-RPAFEVRAVLAATLSPTWGIYSGYELCENTPLREGSEEYLDSE 553 Query: 547 -YVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALA 605 Y P W + T + L +R PAL Sbjct: 554 KYQLKPRDWTRAAREGTTIAP-----------------------LVTRLNTIRRENPALR 590 Query: 606 EGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNF 644 D + + A+ + + +LV+ N Sbjct: 591 ------QLRDLHFHPTDKEEVIAYSKRQGSNTVLVVVNL 623 >2VNC-A nrPDB Length = 718 Score = 90.2 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 34/154 (22%), Positives = 58/154 (37%), Gaps = 27/154 (17%) Query: 59 RADISYQLLLYSFA----DSDGDGYGDLNGVTQK--LDYLNQLGVKALWLSPIHPC---- 108 + + Y++ + F D + G G+ + + YL LG+ + L P+ Sbjct: 172 KDTVIYEVHVKGFTKLRLDLPENIRGTYEGLASEQMISYLKDLGITTVELMPVFHFIDQR 231 Query: 109 -------MSYHGYDVTDYTKVNPQL-------GTESDFDRLVTEAHNRGIKIYLDYVMNH 154 +Y GYD ++ + G F ++V E HN GI++ +D V NH Sbjct: 232 FLTDKGLTNYWGYDPINFFSPECRYSSTGCLGGQVLSFKKMVNELHNAGIEVIIDVVYNH 291 Query: 155 TGTA-HPWFTEASSSSESPYRNYYSFSEDPKTDI 187 T H T + ++ YY D K Sbjct: 292 TAEGNHLGPTLSFRGIDN--TAYYMLQPDNKRYY 323 Score = 52.4 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 59/397 (14%), Positives = 101/397 (25%), Gaps = 72/397 (18%) Query: 327 NPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWI-ARGVDGL 385 N A M Y+ T G Q + D+ + W+ VDG Sbjct: 309 NTAYYMLQPDNKRYYLDFTGT--------GNTLNLSHPRVIQMVLDSLRYWVTEMHVDGF 360 Query: 386 RLDAVKHIYHSETSEE--NPRFLKMFYEDMNAYYKQKGHTDDF-----------YMIGEV 432 R D + S N F+ + + + + K D Y E Sbjct: 361 RFDLAAALARELYSVNMLNTFFIALQQDPILSQVKLIAEPWDVGQGGYQVGNFPYQWAEW 420 Query: 433 LSEYD---------KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYAN 483 +Y + PY + L Y ++ Y + + Sbjct: 421 NGKYRDSIRRFWRGEALPYSEIANRLLGSPDIYLGNNKTPFASINYVTSHDGFTLEDLVS 480 Query: 484 YRSDYIEATKLSNHD--EDRTSSKLGK------------SADKCKLAAAVLLTSAGHPYI 529 Y + EA +N D + S G + + LL S G P I Sbjct: 481 YNQKHNEANGFNNQDGMNENYSWNCGAEGPTNDQNVVICREKQKRNFMITLLVSQGTPMI 540 Query: 530 YYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLN 589 G+EL R+ + + T + L Sbjct: 541 LGGDEL------------SRT----QRGNNNAFCQDNEITWFD-----WNLDERKSKFLE 579 Query: 590 IYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKL-----LVIHNF 644 + + +PA + KD D + LVI Sbjct: 580 FVKKMIQFYRAHPAFRRERYFQGKKLFGMPLKDVTFYTLEGREVDEKTWSSPTQLVIFVL 639 Query: 645 GGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLG 681 G+ M + E++ + N + ++ +K Sbjct: 640 EGSVMD-EINMYGERIADDSFLIILNANPNNVKVKFP 675 >3K1D-A nrPDB Length = 722 Score = 85.6 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 9/101 (8%) Query: 64 YQLLLYSFADSDGDGYGDLNGVTQKL-DYLNQLGVKALWLSPI--HPCMSYHGYDVTDYT 120 Y++ L S+ + ++L DY+ G + L P+ HP GY VT Y Sbjct: 249 YEVHLGSWRPGL-----SYRQLARELTDYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYY 303 Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPW 161 + GT DF LV H GI + +D+V H W Sbjct: 304 APTSRFGTPDDFRALVDALHQAGIGVIVDWVPAHF-PKDAW 343 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 46/337 (13%), Positives = 96/337 (28%), Gaps = 61/337 (18%) Query: 341 FHSHFCTDWFADLNYGP-VDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHSET 398 + H L++G V G + A W+ +DGLR+DAV + + + Sbjct: 353 LYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYWLQEFHIDGLRVDAVASMLYLDY 412 Query: 399 SEENPRFLK------------MFYEDMNAYYKQKGHTDDFYMIGE---VLSEYDKVAPY- 442 S + F ++MNA I E S + Sbjct: 413 SRPEGGWTPNVHGGRENLEAVQFLQEMNA--TAHKVAPGIVTIAEESTPWSGVTRPTNIG 470 Query: 443 YKGLPALFEFSFWYR-LEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED- 500 G + + + L++ + + +++ YA + +Y+ +HDE Sbjct: 471 GLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSMLYA-FSENYVLPL---SHDEVV 526 Query: 501 --------RTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPM 552 R A + A G ++ G+E G + + + Sbjct: 527 HGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQEFGQRA-----EWSEQRGL 581 Query: 553 LWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKH 612 W ++ + + + + + +PAL + T Sbjct: 582 DWFQLDENGFS---------------------NGIQRLVRDINDIYRCHPALWSLDTTPE 620 Query: 613 SVYNESQEKDYKPIAAWYMTKDNEKLL-VIHNFGGTA 648 + ++ + +L + NF G Sbjct: 621 GYSWIDANDSANNVLSFMRYGSDGSVLACVFNFAGAE 657 >5E70-A nrPDB Length = 612 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 31/115 (26%), Positives = 46/115 (40%), Gaps = 6/115 (5%) Query: 63 SYQLLLYSFAD-SDGDGYGDLNGVTQKL-DYLNQLGVKALWLSPI--HPCMSYHGYDVTD 118 Y++ L S+ +D + + + +L Y +G L L PI HP GY T Sbjct: 129 IYEVHLGSWRRHTDNNFWLSYRELADQLVPYAKWMGFTHLELLPINEHPFDGSWGYQPTG 188 Query: 119 YTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPY 173 + GT DF + AH G+ + LD+V H T F A + Y Sbjct: 189 LYAPTRRFGTRDDFRYFIDAAHAAGLNVILDWVPGHFPTDD--FALAEFDGTNLY 241 Score = 49.0 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 70/208 (33%), Gaps = 24/208 (11%) Query: 360 QAGESPAYQAIADAAKGWIA-RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYK 418 G + A WI G+D LR+DAV + + + S + ++ + Sbjct: 260 NYGRREVSNFLVGNALYWIERFGIDALRVDAVASMIYRDYSRKEGEWIPNEFGGRENLEA 319 Query: 419 QKGHTDDFYMIGEVLSEYDKVAPYYKGLPAL------FEFSFWYRLEWGINNSTGCYFAK 472 + + ++GE +S +A P + FWY+ G + T Y Sbjct: 320 IEFLRNTNRILGEQVSGAVTMAEESTDFPGVSRPQDMGGLGFWYKWNLGWMHDTLDYMKL 379 Query: 473 DILSYQQKYANYRSDYIEATKLSN------HDED-----RTSSKLGKSADK----CKLAA 517 D + Y+Q + + + I N HDE ++ A + + Sbjct: 380 DPV-YRQYHHDKLTFGILYNYTENFVLPLSHDEVVHGKKSILDRMPGDAWQKFANLRAYY 438 Query: 518 AVLLTSAGHPYIYYGEELGLYGTKDNGD 545 + G ++ G E G + N D Sbjct: 439 GWMWAFPGKKLLFMGNEFA-QGREWNHD 465 >1E3X-A nrPDB Length = 483 Score = 81.3 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 81/222 (36%), Gaps = 37/222 (16%) Query: 71 FADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP--CMSYHGYDVTDYTK------- 121 + +DG + L ++L+ +G+ A+W+ P + S +GY D Sbjct: 12 YTPNDGQHWKRLQ---NDAEHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQK 68 Query: 122 --VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNY--- 176 V + GT+S+ + H+R +++Y D V+NH A + RN Sbjct: 69 GTVRTKYGTKSELQDAIGSLHSRNVQVYGDVVLNHKAGADATEDVTAVEVNPANRNQETS 128 Query: 177 --YSFSEDPKTDIAAGKIAMITQE-GAAGYNAAEWFQVSDETAAVKGLLKFT-----LDW 228 Y + ++ A+W DE+ + + KF DW Sbjct: 129 EEYQIKAWTDFRFPGRGNTYSDFKWHWYHFDGADW----DESRKISRIFKFRGEGKAWDW 184 Query: 229 ----SNAPSPILVVSTGTKADEDNPDTGTDNAKY-LYYGEDI 265 N L+ + D D+PD + K+ ++Y ++ Sbjct: 185 EVSSENGNYDYLMYA---DVDYDHPDVVAETKKWGIWYANEL 223 Score = 59.7 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 44/231 (19%), Positives = 79/231 (34%), Gaps = 25/231 (10%) Query: 312 EKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIA 371 E +++ FK G + S+ Y + + AD++Y D E+ + Sbjct: 165 ESRKISRIFKFRGEGKAWDWEVSSENGNYDYLMY-----ADVDYDHPDVVAETKKWGIWY 219 Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 +DG R+DA KHI S FL+ + + + + + + + E Sbjct: 220 AN-----ELSLDGFRIDAAKHIKFS--------FLRDWVQAVR-----QATGKEMFTVAE 261 Query: 432 VLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 Y + + F L + + ++ D+ + Sbjct: 262 YWQNNAGKLENYLNKTSFNQSVFDVPLHFNLQAASSQGGGYDMRKLLNGTVVSKHPLKSV 321 Query: 492 TKLSNHDEDRTSSKLGKSADKCK-LAAAVLLTSA-GHPYIYYGEELGLYGT 540 T + NHD S K LA A +LT G+P ++YG+ G G Sbjct: 322 TFVDNHDTQPGQSLESTVQTWFKPLAYAFILTRESGYPQVFYGDMYGTKGD 372 >1MXD-A nrPDB Length = 435 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 52/140 (37%), Gaps = 23/140 (16%) Query: 74 SDGDGYGDLNG-VTQKLDYLNQLGVKALWLSPIHPCMS---YHGYDVTDYTK-------- 121 D G G + K+ + G+ A+WL P MS GYD DY Sbjct: 18 WDVPGGGIWWDHIRSKIPEWYEAGISAIWLPPPSKGMSGGYSMGYDPYDYFDLGEYYQKG 77 Query: 122 -VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH-PWFTEASSSSESPYRNYYSF 179 V + G++ + RL+ AH GIK+ D V+NH W +P+ Y++ Sbjct: 78 TVETRFGSKEELVRLIQTAHAYGIKVIADVVINHRAGGDLEW---------NPFVGDYTW 128 Query: 180 SEDPKTDIAAGKIAMITQEG 199 ++ K + Sbjct: 129 TDFSKVASGKYTANYLDFHP 148 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 32/155 (20%), Positives = 58/155 (37%), Gaps = 31/155 (20%) Query: 381 GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLS-EYDKV 439 G DG R D VK Y + + + + +GE D + Sbjct: 191 GFDGWRFDYVKG-YGAWVVRDWLNWWGG------------------WAVGEYWDTNVDAL 231 Query: 440 APY-YKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHD 498 + Y+ +F+F +Y+++ +N+ + + Q + R + T ++NHD Sbjct: 232 LSWAYESGAKVFDFPLYYKMDEAFDNNNIPALVYALQNGQTVVS--RDPFKAVTFVANHD 289 Query: 499 EDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGE 533 D +K A A +LT G P I+Y + Sbjct: 290 TDIIWNKY--------PAYAFILTYEGQPVIFYRD 316 >3BH4-A nrPDB Length = 483 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 81/222 (36%), Gaps = 37/222 (16%) Query: 71 FADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHP--CMSYHGYDVTDYTK------- 121 + +DG + L ++L+ +G+ A+W+ P + S +GY D Sbjct: 12 YTPNDGQHWKRLQ---NDAEHLSDIGITAVWIPPAYKGLSQSDNGYGPYDLYDLGEFQQK 68 Query: 122 --VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNY--- 176 V + GT+S+ + H+R +++Y D V+NH A + RN Sbjct: 69 GTVRTKYGTKSELQDAIGSLHSRNVQVYGDVVLNHKAGADATEDVTAVEVNPANRNQETS 128 Query: 177 --YSFSEDPKTDIAAGKIAMITQE-GAAGYNAAEWFQVSDETAAVKGLLKFT-----LDW 228 Y + ++ A+W DE+ + + KF DW Sbjct: 129 EEYQIKAWTDFRFPGRGNTYSDFKWHWYHFDGADW----DESRKISRIFKFRGEGKAWDW 184 Query: 229 ----SNAPSPILVVSTGTKADEDNPDTGTDNAKY-LYYGEDI 265 N L+ + D D+PD + K+ ++Y ++ Sbjct: 185 EVSSENGNYDYLMYA---DVDYDHPDVVAETKKWGIWYANEL 223 Score = 59.4 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 80/234 (34%), Gaps = 25/234 (10%) Query: 312 EKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIA 371 E +++ FK G + S+ Y + + AD++Y D E+ + Sbjct: 165 ESRKISRIFKFRGEGKAWDWEVSSENGNYDYLMY-----ADVDYDHPDVVAETKKWGIWY 219 Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 +DG R+DA KHI S FL+ + + + + + + + E Sbjct: 220 AN-----ELSLDGFRIDAAKHIKFS--------FLRDWVQAVR-----QATGKEMFTVAE 261 Query: 432 VLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 Y + + F L + + ++ D+ R Sbjct: 262 YWQNNAGKLENYLNKTSFNQSVFDVPLHFNLQAASSQGGGYDMRRLLDGTVVSRHPEKAV 321 Query: 492 TKLSNHDEDRTSSKLGKSADKCK-LAAAVLLTSA-GHPYIYYGEELGLYGTKDN 543 T + NHD S K LA A +LT G+P ++YG+ G GT Sbjct: 322 TFVENHDTQPGQSLESTVQTWFKPLAYAFILTRESGYPQVFYGDMYGTKGTSPK 375 >6JEQ-A nrPDB Length = 675 Score = 80.2 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 61/165 (36%), Gaps = 46/165 (27%) Query: 40 VEGQWTAL----TASPDTWDETKR-------ADISYQLLLYSFADSDGDGY---GDLNGV 85 V G TA+ + +P+ W+ ++ + Y+L + + G G G+ Sbjct: 124 VNGTKTAILDLRSTNPEGWENDQKPPLASPTDAVIYELHVRDLSIHPQSGIREKGKFLGL 183 Query: 86 TQK-----------LDYLNQLGVKALWLSPIHPCMS-------------YHGYDVTDYTK 121 T++ LD++ LGV + L PI+ GYD +Y Sbjct: 184 TEEGTRGPNGIPTGLDHITGLGVTHVQLLPIYDYSQESVDESRLDEPHYNWGYDPQNYNV 243 Query: 122 VNPQLGTES--------DFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 T+ + RL+ + H RG+++ +D V NH Sbjct: 244 PEGSYSTDPHNPAARILELKRLIQKLHARGLRVIMDVVYNHVYDG 288 Score = 66.7 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 111/350 (31%), Gaps = 47/350 (13%) Query: 340 YFHSHFCTDWFADLNYGPVDQAGESPA-YQAIADAAKGWI-ARGVDGLRLDAVKHIYHSE 397 Y+ + F+D + + A E P + I ++ W+ +DG R D + I Sbjct: 300 YYLRYKADRTFSDGTFCGNECASERPIMRKYIIESILHWVREYHIDGFRFDLMGMIDIET 359 Query: 398 TSEENPRFLK----------MFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLP 447 +E R + + + + + + D+ + + D + KG Sbjct: 360 MNEIRRRLDEIDPTILTIGEGWMMETVLPKELRANQDNAEKLPGIGMFNDGMRDAVKGDI 419 Query: 448 ALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED------R 501 +F+ + G + A I Q + HD Sbjct: 420 FIFDRKGFISGGDGFEDGVKRGVAGGINYGGQLRQFAVEPVQSVNYVECHDNHTLWDKIE 479 Query: 502 TSSKLGKSADKC---KLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSY 558 S+ ++ +LA+A++LTS G P+++ G+E ++R+ Sbjct: 480 LSTPGASDEERRAMHRLASAIVLTSQGIPFLHAGQE------------FMRT-------- 519 Query: 559 TTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNES 618 + + + N A + + SL LR +PA + + Sbjct: 520 KGGVENSYKSPIEVNWLDWERCAAHQDDV-SYMRSLIALRKAHPAFRLKTADEIRAHLRF 578 Query: 619 QEKDYKPIAAWYMTKD----NEKLLVIHNFGGTAMQLPLT-DKIEKVLFV 663 + +A + L V++N A+ L L +V F Sbjct: 579 EAAPPHTVAFTLRDHAGGDPDRHLYVLYNANPGALSLELPALGPWEVRFG 628 >5GQY-A nrPDB Length = 793 Score = 79.4 bits (194), Expect = 5e-15, Method: Composition-based stats. Identities = 24/73 (32%), Positives = 34/73 (46%), Gaps = 3/73 (4%) Query: 85 VTQKL-DYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHN 141 + +KL Y+ +G + L PI HP GY VT + + G DF V + H Sbjct: 317 LAEKLIPYVKDMGYTHIELLPIAEHPFDGSWGYQVTGFYSPTSRFGRPEDFMYFVDKCHE 376 Query: 142 RGIKIYLDYVMNH 154 GI + LD+V H Sbjct: 377 NGIGVILDWVPGH 389 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 92/313 (29%), Gaps = 52/313 (16%) Query: 360 QAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYE-----DM 413 G + W + VDG+R+DAV + + + ++ Y + Sbjct: 425 NYGRHEVRNFLVANVLFWFDKYHVDGIRVDAVASMLYRNYLRKEGEWIANEYGGDEHIEA 484 Query: 414 NAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKD 473 ++ ++ Y G +LS ++ + K +++ + L+W + + Sbjct: 485 VSFIREVNTLLFEYFPG-ILSIAEESTEWEKVSRPVYDGGLGFNLKWDMGWMHDMLDYFN 543 Query: 474 ILSYQQKYAN----------YRSDYIEATKLS--NHDEDRTSSKLGKSADK----CKLAA 517 I Y ++Y Y +++ A H + K+ + + Sbjct: 544 IDPYFRQYHQNNVTFSMLYYYNENFMLALSHDEIVHGKSNMLGKMPGDEWQKYANVRALF 603 Query: 518 AVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTV 577 + T G ++ E G W + + + + Sbjct: 604 TYMYTHPGKKTMFMSMEFG----------------QWSEWNVWGDLEWHLLQYEPHQQ-- 645 Query: 578 ADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKD--N 635 L + L L PAL + H + + ++ D N Sbjct: 646 ---------LKQFFTDLNALYQQEPALYTHDFEYHGFEWIDCNDNTHSVVSFLRRSDDPN 696 Query: 636 EKLLVIHNFGGTA 648 + L+V+ NF Sbjct: 697 DSLVVVCNFTPQP 709 >4UZU-A nrPDB Length = 513 Score = 79.0 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 39/170 (22%), Positives = 66/170 (38%), Gaps = 25/170 (14%) Query: 80 GDLNG-VTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------VNPQLG 127 G L V + + L+ LG+ ALWL P + S Y YD+ D + V + G Sbjct: 20 GTLWTKVANEANNLSSLGITALWLPPAYKGTSRSDVGYGVYDLYDLGEFNQKGTVRTKYG 79 Query: 128 TESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH--PWFTEASSSSESPYRNY---YSFSED 182 T++ + + + AH G+++Y D V +H G A W + + Y Sbjct: 80 TKAQYLQAIQAAHAAGMQVYADVVFDHKGGADGTEWVDAVEVNPSDRNQEISGTYQIQAW 139 Query: 183 PKTDIAAGKIAMITQE-GAAGYNAAEWFQVSDETAAVKGLLKFT---LDW 228 K D + + ++ +W DE+ + + KF DW Sbjct: 140 TKFDFPGRGNTYSSFKWRWYHFDGVDW----DESRKLSRIYKFRGKAWDW 185 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 44/218 (20%), Positives = 76/218 (34%), Gaps = 35/218 (16%) Query: 326 GNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDG 384 G + D++ Y + + ADL+ + + K ++ +DG Sbjct: 180 GKAWDWEVDTEFGNYDYLMY-----ADLDMD------HPEVVTELKNWGKWYVNTTNIDG 228 Query: 385 LRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYY- 443 RLDAVKHI F+ D +Y + + + +GE S Y Sbjct: 229 FRLDAVKHIKF------------SFFPDWLSYVRSQTGKP-LFTVGEYWSYDINKLHNYI 275 Query: 444 ---KGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED 500 G +LF+ L ++ A D+ + + T + NHD + Sbjct: 276 TKTDGTMSLFDAP----LHNKFYTASKSGGAFDMRTLMTNTLMKDQPTLAVTFVDNHDTE 331 Query: 501 RTSSKLG-KSADKCKLAAAVLLT-SAGHPYIYYGEELG 536 + LA A +LT G+P ++YG+ G Sbjct: 332 PGQALQSWVDPWFKPLAYAFILTRQEGYPCVFYGDYYG 369 >3QGV-A nrPDB Length = 435 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 49/131 (37%), Gaps = 22/131 (16%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIHPCMS---YHGYDVTDYTK---------VNPQLGTE 129 + + QK+ G+ A+W+ P M GYD D+ V + G++ Sbjct: 27 WDTIRQKIPEWYDAGISAIWIPPASKGMGGAYSMGYDPYDFFDLGEYDQKGTVETRFGSK 86 Query: 130 SDFDRLVTEAHNRGIKIYLDYVMNHTGTAH-PWFTEASSSSESPYRNYYSFSEDPKTDIA 188 + ++ AH G+K+ D V+NH W +P+ N Y++++ K Sbjct: 87 QELVNMINTAHAYGMKVIADIVINHRAGGDLEW---------NPFVNDYTWTDFSKVASG 137 Query: 189 AGKIAMITQEG 199 + Sbjct: 138 KYTANYLDFHP 148 Score = 50.5 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 32/155 (20%), Positives = 57/155 (36%), Gaps = 31/155 (20%) Query: 381 GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLS-EYDKV 439 G+D R D VK Y ++ + + +GE D V Sbjct: 191 GIDAWRFDYVKG-YAPWVVKDWLNWWGG------------------WAVGEYWDTNVDAV 231 Query: 440 APY-YKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHD 498 + Y +F+F+ +Y+++ +N + + Q + R + T ++NHD Sbjct: 232 LNWAYSSGAKVFDFALYYKMDEAFDNKNIPALVSALQNGQTVVS--RDPFKAVTFVANHD 289 Query: 499 EDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGE 533 D +K A A +LT G P I+Y + Sbjct: 290 TDIIWNKY--------PAYAFILTYEGQPTIFYRD 316 >1BLI-A nrPDB Length = 483 Score = 77.8 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 27/101 (26%), Positives = 45/101 (44%), Gaps = 14/101 (13%) Query: 71 FADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK---- 121 + +DG + L + YL + G+ A+W+ P + S Y YD+ D + Sbjct: 14 YMPNDGQHWKRLQNDSA---YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQK 70 Query: 122 --VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 V + GT+ + + H+R I +Y D V+NH G A Sbjct: 71 GTVRTKYGTKGELQSAIKSLHSRDINVYGDVVINHKGGADA 111 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 77/231 (33%), Gaps = 27/231 (11%) Query: 312 EKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIA 371 E LN+ +K G + ++ Y + + AD++Y D A E + Sbjct: 167 ESRKLNRIYKFQ--GKAWDWEVSNEFGNYDYLMY-----ADIDYDHPDVAAEIKRWGTWY 219 Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 +DG RLDAVKHI F D + ++K + + + E Sbjct: 220 AN-----ELQLDGFRLDAVKHIKF------------SFLRDWVNHVREKTGK-EMFTVAE 261 Query: 432 VLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 S Y F L + + ++ D+ + Sbjct: 262 YWSYDLGALENYLNKTNFNHSVFDVPLHYQFHAASTQGGGYDMRKLLNGTVVSKHPLKSV 321 Query: 492 TKLSNHDEDRTSSKLGKSADKCK-LAAAVLLTSA-GHPYIYYGEELGLYGT 540 T + NHD S K LA A +LT G+P ++YG+ G G Sbjct: 322 TFVDNHDTQPGQSLESTVQTWFKPLAYAFILTRESGYPQVFYGDMYGTKGD 372 >1BPL-A nrPDB Length = 189 Score = 76.3 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 27/101 (26%), Positives = 45/101 (44%), Gaps = 14/101 (13%) Query: 71 FADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK---- 121 + +DG + L + YL + G+ A+W+ P + S Y YD+ D + Sbjct: 14 YMPNDGQHWKRLQNDSA---YLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQK 70 Query: 122 --VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 V + GT+ + + H+R I +Y D V+NH G A Sbjct: 71 GTVRTKYGTKGELQSAIKSLHSRDINVYGDVVINHKGGADA 111 >2WSK-A nrPDB Length = 657 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 64/184 (34%), Gaps = 34/184 (18%) Query: 31 DPAPEPEPPVEGQWTALTASPDTWDETKR-----ADISYQLLLYSFA----DSDGDGYGD 81 +P + + + D D+ + I Y+ + + + G Sbjct: 116 EPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGT 175 Query: 82 LNGVTQK--LDYLNQLGVKALWLSPIHPCMS-----------YHGYDVTDYTKVNPQLG- 127 + ++YL QLG+ AL L P+ S Y GY+ ++P Sbjct: 176 YKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYAC 235 Query: 128 ----TESDFDRLVTEAHNRGIKIYLDYVMNHTGT---AHPWFTEASSSSESPYRNYYSFS 180 +F + H GI++ LD V+NH+ P F + ++ R+YY Sbjct: 236 SPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLF--SLRGIDN--RSYYWIR 291 Query: 181 EDPK 184 ED Sbjct: 292 EDGD 295 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 49/374 (13%), Positives = 96/374 (25%), Gaps = 75/374 (20%) Query: 337 QITYFHSHFCTDWFADLNY---GPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKH 392 + Y+ N+ G + + W+ VDG R D Sbjct: 285 RSYYWIREDGDYH----NWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAV 340 Query: 393 IYHSETSEENPRFLKMF-----YEDMNAYYKQKGHTDDFYMIG-------EVLSEYDKVA 440 + + ++ + + Y +G E + A Sbjct: 341 MGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPGGYQVGNFPPLFAEWNDHFRDAA 400 Query: 441 --PYYKGLPALFEFSFWYRLEWGINNSTGC--------------YFAKDILSYQQKY--- 481 + L F+ + + G + +D + + K+ Sbjct: 401 RRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEA 460 Query: 482 -ANYRSDYIEATKLSNHDEDRTSSKLG---KSADKCKLAAAVLLTSAGHPYIYYGEELGL 537 D +NH ++ L + D LL S G P + G+E Sbjct: 461 NGEENRDGTNNNYSNNHGKEGLGGSLDLVERRRDSIHALLTTLLLSQGTPMLLAGDE--- 517 Query: 538 YGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRL 597 +G +G+ A N T D + L +L L Sbjct: 518 HGHSQHGNNN--------------------AYCQDNQLTWLDWSQASSGLTAFTAALIHL 557 Query: 598 RNTYPALA------EGNMTKHSVYNESQEK---DYKPIAAWYMTKDNEKLLVIHNFGGTA 648 R PAL EG+ + +Q +++ +++ L+ N Sbjct: 558 RKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEV 617 Query: 649 MQLPLTDKIEKVLF 662 ++ L + Sbjct: 618 TEIVLPAGEWHAIP 631 >2D3L-A nrPDB Length = 485 Score = 75.5 bits (184), Expect = 7e-14, Method: Composition-based stats. Identities = 33/136 (24%), Positives = 50/136 (36%), Gaps = 19/136 (13%) Query: 71 FADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK---- 121 + +DG+ + LN L G+ A+W+ P S Y YD+ D + Sbjct: 16 YLPNDGNHWNRLNSDASNL---KSKGITAVWIPPAWKGASQNDVGYGAYDLYDLGEFNQK 72 Query: 122 --VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTG--TAHPWFTEASSSSESPYRNY- 176 V + GT S VT N GI++Y D VMNH G A + + + Sbjct: 73 GTVRTKYGTRSQLQAAVTSLKNNGIQVYGDVVMNHKGGADATEMVRAVEVNPNNRNQEVT 132 Query: 177 --YSFSEDPKTDIAAG 190 Y+ + D Sbjct: 133 GEYTIEAWTRFDFPGR 148 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 44/237 (18%), Positives = 81/237 (34%), Gaps = 30/237 (12%) Query: 317 NKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG 376 N+ +K G + D++ Y + + AD++ + + Sbjct: 175 NRIYKFRGHGKAWDWEVDTENGNYDYLMY-----ADIDMD------HPEVVNELRNWGVW 223 Query: 377 WIA-RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSE 435 + G+DG R+DAVKHI + F D + + + + + E Sbjct: 224 YTNTLGLDGFRIDAVKHIKY------------SFTRDWINHVRSATGK-NMFAVAEFWKN 270 Query: 436 YDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS 495 Y F L + + N++ D+ + R T + Sbjct: 271 DLGAIENYLQKTNWNHSVFDVPLHYNLYNASKSGGNYDMRNIFNGTVVQRHPSHAVTFVD 330 Query: 496 NHD-EDRTSSKLGKSADKCKLAAAVLLT-SAGHPYIYYGEELGLYGTKDNGDEYVRS 550 NHD + + + LA A+ LT G+P ++YG+ YG +G +RS Sbjct: 331 NHDSQPEEALESFVEEWFKPLAYALTLTREQGYPSVFYGD---YYGIPTHGVPAMRS 384 >6GXV-A nrPDB Length = 484 Score = 74.0 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 40/194 (20%), Positives = 73/194 (37%), Gaps = 19/194 (9%) Query: 80 GDLNG-VTQKLDYLNQLGVKALWLSPIHPCMS--------YHGYDVTDYTK---VNPQLG 127 G L + +L +G+ +W P + S Y YD+ ++ + V + G Sbjct: 21 GTLWTKMGSDASHLKSIGITGVWFPPAYKGQSQSDVGYGVYDMYDLGEFNQKGTVRTKYG 80 Query: 128 TESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRN-----YYSFSED 182 T++ +T HN GI+ Y D V+NH A T ++ RN Y+ S Sbjct: 81 TKAQLQSAITSLHNNGIQAYGDVVLNHRMGADATETISAVEVNPSNRNQVTSGAYNISAW 140 Query: 183 PKTDIAAGKIAMITQEGAAGY-NAAEWFQVSDETAAVKGLLKFTLDWS-NAPSPILVVST 240 + + + + Y + +W Q + + + DW ++ + Sbjct: 141 TDFEFPGRGNTYSSFKWHSYYFDGVDWDQSRQLSGKIYQIQGKAWDWEVDSENGNYDYLM 200 Query: 241 GTKADEDNPDTGTD 254 G D D+PD T+ Sbjct: 201 GADIDYDHPDVQTE 214 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 40/218 (18%), Positives = 72/218 (33%), Gaps = 34/218 (15%) Query: 326 GNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIA-RGVDG 384 G + DS+ Y + AD++Y + + K ++ +DG Sbjct: 182 GKAWDWEVDSENGNYDYLMG-----ADIDYD------HPDVQTEVKNWGKWFVNTLNLDG 230 Query: 385 LRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYK 444 +RLDAVKHI + + K + + +GE + Y+ Sbjct: 231 VRLDAVKHIKFD------------YMSSWLSSVKSTTGKSNLFAVGEYWNTSLGALENYE 278 Query: 445 G----LPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED 500 +LF+ + N G Y+ D+ + T + NHD + Sbjct: 279 NKTNWSMSLFDVPLHMNFQAAANG--GGYY--DMRNLLNNTMMKNHPIQAVTFVDNHDTE 334 Query: 501 --RTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELG 536 + K A +L G+P ++YG+ G Sbjct: 335 PGQALQSWVSDWFKPLAYATILTRQEGYPCVFYGDYYG 372 >1AVA-A nrPDB Length = 403 Score = 72.5 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 2/97 (2%) Query: 65 QLLLYSFA-DSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVN 123 Q+L F +S G N + K+D + G+ +WL P ++ GY ++ Sbjct: 1 QVLFQGFNWESWKHNGGWYNFLMGKVDDIAAAGITHVWLPPASQSVAEQGYMPGRLYDLD 60 Query: 124 -PQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH 159 + G ++ L+ H +G+K D V+NH H Sbjct: 61 ASKYGNKAQLKSLIGALHGKGVKAIADIVINHRTAEH 97 Score = 52.8 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 40/202 (19%), Positives = 61/202 (30%), Gaps = 35/202 (17%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWI--ARGVDGLRLDAVK---------HIYHS 396 D AD P + + + W+ G DG R D K +I S Sbjct: 138 DTGADFGAAPDIDHLNLRVQKELVEWLN-WLKADIGFDGWRFDFAKGYSADVAKIYIDRS 196 Query: 397 ETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWY 456 E S + E+++ DKV KG F+F+ Sbjct: 197 EPSFAVAEIWTSLAYGGDGKPNLNQDQHR----QELVNWVDKVG--GKGPATTFDFTTKG 250 Query: 457 RLE-------WGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKS 509 L W + + G A ++ + T + NHD T Sbjct: 251 ILNVAVEGELWRLRGTDGK--APGMIGWW--------PAKAVTFVDNHDTGSTQHMWPFP 300 Query: 510 ADKCKLAAAVLLTSAGHPYIYY 531 +D+ A +LT G P I+Y Sbjct: 301 SDRVMQGYAYILTHPGTPCIFY 322 >2DIE-A nrPDB Length = 485 Score = 72.5 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 14/97 (14%) Query: 73 DSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------ 121 +DG+ + L L G+ A+W+ P S Y YD+ D + Sbjct: 18 PNDGNHWNRLRDDAANL---KSKGITAVWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGT 74 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTA 158 V + GT S VT N GI++Y D VMNH G A Sbjct: 75 VRTKYGTRSQLQGAVTSLKNNGIQVYGDVVMNHKGGA 111 Score = 49.7 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 40/228 (17%), Positives = 77/228 (33%), Gaps = 37/228 (16%) Query: 317 NKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG 376 NK +K G + D + Y + + AD++ + + Sbjct: 175 NKIYKFRGTGKAWDWEVDIENGNYDYLMY-----ADIDMD------HPEVINELRNWGVW 223 Query: 377 WIA-RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSE 435 + +DG R+DAVKHI + + D + + + + E Sbjct: 224 YTNTLNLDGFRIDAVKHIKY------------SYTRDWLTHVRNTTGKP-MFAVAEFWKN 270 Query: 436 YDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS 495 Y + F L + + N++ D+ + + T + Sbjct: 271 DLAAIENYLNKTSWNHSVFDVPLHYNLYNASNSGGYFDMRNILNGSVVQKHPIHAVTFVD 330 Query: 496 NHDEDRTSSKLGKSADKC------KLAAAVLLT-SAGHPYIYYGEELG 536 NHD S+ G++ + LA A++LT G+P ++YG+ G Sbjct: 331 NHD-----SQPGEALESFVQSWFKPLAYALILTREQGYPSVFYGDYYG 373 >3BCF-A nrPDB Length = 599 Score = 72.1 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 28/120 (23%), Positives = 47/120 (39%), Gaps = 13/120 (10%) Query: 48 TASPDTWDETKRADISY-QLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIH 106 PD Y ++ +A + N + ++ L + G A+WL P + Sbjct: 114 PQIPDQEVNHTILQAFYWEMNTGEYATEHPEEANLWNLLAERAPELAEAGFTAVWLPPAN 173 Query: 107 PCM------SYHGYDVTDYTK------VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNH 154 M Y YD+ D + V + GT+ + + + HN IK+Y D V+NH Sbjct: 174 KGMAGIHDVGYGTYDLWDLGEFDQKGTVRTKYGTKGELENAIDALHNNDIKVYFDAVLNH 233 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 61/203 (30%), Gaps = 26/203 (12%) Query: 342 HSHFCTDWFADLNY-----GPVDQAGESPAYQAIADAAKG--WI--ARGVDGLRLDAVKH 392 + W N+ D E+ A Q D WI DG RLDAVKH Sbjct: 297 YLFDEKSWDWTYNWDEDYLMGADVDYENEAVQN--DVIDWGQWIINNIDFDGFRLDAVKH 354 Query: 393 IYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEF 452 I + RF+ + + D + +GE E + + Sbjct: 355 IDY--------RFIDKWMSAVQN-----SSNRDVFFVGEAWVEDVDDLKGFLDTVGNPDL 401 Query: 453 SFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADK 512 + L + + T + NHD DR S Sbjct: 402 RVFDFPLRSFFVDMLNGAYMADLRNAGLVNSPGYENRAVTFVDNHDTDRDEGSYTVSIYS 461 Query: 513 CK-LAAAVLLT-SAGHPYIYYGE 533 K A A +LT + G P +Y+ + Sbjct: 462 RKYQAYAYILTRAEGVPTVYWKD 484 >3WN6-A nrPDB Length = 404 Score = 72.1 bits (175), Expect = 9e-13, Method: Composition-based stats. Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 2/97 (2%) Query: 65 QLLLYSFA-DSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVN 123 Q+L F +S + G N + K+D + G+ +WL P + GY ++ Sbjct: 2 QVLFQGFNWESWKENGGWYNFLMGKVDDIAAAGITHVWLPPPSHSVGEQGYMPGRLYDLD 61 Query: 124 -PQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH 159 + G E+ L+ H +G+++ D V+NH H Sbjct: 62 ASKYGNEAQLKSLIEAFHGKGVQVIADIVINHRTAEH 98 Score = 51.7 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 61/199 (30%), Gaps = 28/199 (14%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGW-IARGVDGLRLDAVKH-------IYHSETS 399 D AD P + + + G D RLD K IY T Sbjct: 138 DTGADFAAAPDIDHLNKRVQRELIGWLDWLKMDIGFDAWRLDFAKGYSADMAKIYIDATE 197 Query: 400 EENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLE 459 + + M K + D E+++ D+V A F+F+ L Sbjct: 198 PSFA--VAEIWTSMANGGDGKPNYDQNAHRQELVNWVDRVGGANSNATA-FDFTTKGILN 254 Query: 460 -------WGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADK 512 W + G A ++ + T + NHD T +DK Sbjct: 255 VAVEGELWRLRGEDGK--APGMIGWW--------PAKATTFVDNHDTGSTQHLWPFPSDK 304 Query: 513 CKLAAAVLLTSAGHPYIYY 531 A +LT G+P I+Y Sbjct: 305 VMQGYAYILTHPGNPCIFY 323 >3WDH-A nrPDB Length = 710 Score = 71.3 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 42/127 (33%), Gaps = 32/127 (25%) Query: 60 ADISYQLLLYSFADSDGDGY---GDLNGVTQK-----------LDYLNQLGVKALWLSPI 105 I Y++ + F G G G+T++ L Y+ QLGV + L P+ Sbjct: 221 DAIIYEMHIRDFTIHHESGVRQKGKYVGLTERGTTGPNGTLTGLSYIKQLGVTHVQLMPV 280 Query: 106 HPCMS----------YHGYDVTDYTKVNPQLGTESD--------FDRLVTEAHNRGIKIY 147 GY+ Y T+ D R + GI++ Sbjct: 281 QDFEGVDELQPLKMYNWGYNTVHYNAPEGSYATDPDDPYARIIELKRAIRAFQQEGIRVI 340 Query: 148 LDYVMNH 154 LD V NH Sbjct: 341 LDVVYNH 347 Score = 64.4 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 54/345 (15%), Positives = 100/345 (28%), Gaps = 76/345 (22%) Query: 356 GPVDQAGESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMN 414 G + + I D+ W+ GVDG R D + I +T + R + Sbjct: 380 GNDLASERKMVKKFIIDSVTYWLKEYGVDGFRFD-LMGILDIDTMNDVRRAIDEI----- 433 Query: 415 AYYKQKGHTDDFYMIGEVL-------SEYDKVAPYYKGLPAL--FEFSFWYRLEWGINNS 465 ++GE SE K P + F F ++ + Sbjct: 434 --------DPTVIILGEGWDLATPLPSEKKTTIANAKHTPRIAYFNDRFRDYVKGSTFDI 485 Query: 466 TGCYFAKDILSYQQKYANYRSDYIE--------ATKLSNHDEDRTSSKLGK--------- 508 FA SY++ I + HD K+ Sbjct: 486 HERGFALGDCSYKEAVIGAIRGSIHLFFSPRQSVNYVECHDNHTLWDKMAVANAHESEYI 545 Query: 509 SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDA 568 + KLA A++L S G P+++ G+E D Sbjct: 546 RRKRQKLATAIVLLSQGIPFLHSGQEFYRTKKGVENSYN-----------------SPDE 588 Query: 569 TVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDY----K 624 + + + D ++ L LR + G + + + Sbjct: 589 VNQVDWNEKSRWEEDVREIM----KLIELRKKH-----GAFRFLTADQVRRHMKFYDTHP 639 Query: 625 PIAAWYMTKDN-----EKLLVIHNFGGTAMQLPLTDKIEKVLFVN 664 + A+ + ++++V+++ LPL D KV+F + Sbjct: 640 SVIAYQLVDVGVYGPWKQIVVVYHNEEKKAMLPLADGKWKVMFSS 684 >2GJP-A nrPDB Length = 485 Score = 69.8 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 32/140 (22%), Positives = 47/140 (33%), Gaps = 19/140 (13%) Query: 73 DSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------ 121 +DG + L L G+ A+W+ P S Y YD+ D + Sbjct: 18 PNDGQHWNRLRDDASNL---RNRGITAIWIPPAWKGTSQNDVGYGAYDLYDLGEFNQKGT 74 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNY----- 176 V + GT S + + N G+++Y D VMNH G A + RN Sbjct: 75 VRTKYGTRSQLESAIHALKNNGVQVYGDVVMNHKGGADATENVLAVEVNPNNRNQEISGD 134 Query: 177 YSFSEDPKTDIAAGKIAMIT 196 Y+ K D Sbjct: 135 YTIEAWTKFDFPGRGNTYSD 154 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 41/223 (18%), Positives = 75/223 (33%), Gaps = 27/223 (12%) Query: 317 NKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKG 376 N+ +K G + DS+ Y + + AD++ + + Sbjct: 175 NRIYKFRGDGKAWDWEVDSENGNYDYLMY-----ADVDMD------HPEVVNELRRWGEW 223 Query: 377 WIA-RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSE 435 + +DG R+DAVKHI +S F + + + + + + E Sbjct: 224 YTNTLNLDGFRIDAVKHIKYS--------FTRDWLTHVRN-----ATGKEMFAVAEFWKN 270 Query: 436 YDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLS 495 Y F L + + N++ D+ + T + Sbjct: 271 DLGALENYLNKTNWNHSVFDVPLHYNLYNASNSGGNYDMAKLLNGTVVQKHPMHAVTFVD 330 Query: 496 NHDEDRTSSKLGKSADKCK-LAAAVLLT-SAGHPYIYYGEELG 536 NHD S + K LA A++LT G+P ++YG+ G Sbjct: 331 NHDSQPGESLESFVQEWFKPLAYALILTREQGYPSVFYGDYYG 373 >3BSH-A nrPDB Length = 414 Score = 69.8 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 35/76 (46%), Gaps = 1/76 (1%) Query: 80 GDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVN-PQLGTESDFDRLVTE 138 G N + K+D + GV +WL P +S GY ++ + G ++ L+ Sbjct: 18 GWYNMMMGKVDDIAAAGVTHVWLPPPSHSVSNEGYMPGRLYDIDASKYGNAAELKSLIGA 77 Query: 139 AHNRGIKIYLDYVMNH 154 H +G++ D V+NH Sbjct: 78 LHGKGVQAIADIVINH 93 Score = 55.1 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 62/200 (31%), Gaps = 30/200 (15%) Query: 348 DWFADLNYGPVDQAGESPAYQAIADAAKGWI--ARGVDGLRLDAVKHIYHSETSEENPRF 405 D AD P + + + W+ G D RLD + +P Sbjct: 139 DTGADFAAAPDIDHLNDRVQRELKEWL-LWLKSDLGFDAWRLDFAR--------GYSPEM 189 Query: 406 LKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLP------------ALFEFS 453 K++ + + D+ G+ YD+ A + +F+F+ Sbjct: 190 AKVYIDGTSPSLAVAEVWDNMATGGDGKPNYDQDAHRQNLVNWVDKVGGAASAGMVFDFT 249 Query: 454 FWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIE--ATKLSNHDEDRTSSKLGKSAD 511 L + ++ Q K + T + NHD T + +D Sbjct: 250 TKGILNAAVEGE-----LWRLIDPQGKAPGVMGWWPAKAVTFVDNHDTGSTQAMWPFPSD 304 Query: 512 KCKLAAAVLLTSAGHPYIYY 531 K A +LT G P I+Y Sbjct: 305 KVMQGYAYILTHPGIPCIFY 324 >2E8Y-A nrPDB Length = 718 Score = 69.0 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 44/127 (34%), Gaps = 32/127 (25%) Query: 60 ADISYQLLLYSFADSDGDG--------------YGDLNGVTQKLDYLNQLGVKALWLSPI 105 + Y+ L F+ + G NG + L Y+ +LGV + L P+ Sbjct: 214 DAVIYETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPV 273 Query: 106 HPCMS----------YHGYDVTDYTKVNPQLGT--------ESDFDRLVTEAHNRGIKIY 147 + GY+ + + +++ +++ H G+++ Sbjct: 274 NDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVI 333 Query: 148 LDYVMNH 154 LD V NH Sbjct: 334 LDVVFNH 340 Score = 65.5 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 65/392 (16%), Positives = 122/392 (31%), Gaps = 54/392 (13%) Query: 330 NIMFDSQQITYFHSHF-CTDWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRL 387 N F+ YF H C G + A + IAD W+ VDG R Sbjct: 346 NSPFEKTVPGYFFRHDECGKPSNGTGVGNDIASERRMARKFIADCVVYWLEEYNVDGFRF 405 Query: 388 D--------AVKHIYHSETSEENPRFL-KMFYE-------DMNAYYKQKGHTDDFYMIGE 431 D V ++ T + L ++ + A + Sbjct: 406 DLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAALANAPRMPGIGFFND 465 Query: 432 VLSEYDKVAPYYKGLP--ALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYI 489 + + K ++ AL + GI S+G I+ + NY + Sbjct: 466 MFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALAPIVPEPSQSINYVESHD 525 Query: 490 EATKLSNHDEDRTSSKLGKSADKCK--LAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEY 547 T + S + + LA A++L + G P+I+ G+E Sbjct: 526 NHTFWDK--MSFALPQENDSRKRSRQRLAVAIILLAQGVPFIHSGQEFFRTKQGVENS-- 581 Query: 548 VRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEG 607 DS + D++ ++ L LR +PA Sbjct: 582 ----YQSSDSIN---------------QLDWDRRETFKEDVHYIRRLISLRKAHPAFRLR 622 Query: 608 NMTKHSVYNESQEKDYKPIAAWYMTKDNE-----KLLVIHNFGGTAMQLPLTDKIEKVLF 662 + + E + + A+ + +E ++VIH+ +++ L + I L Sbjct: 623 SAADIQRHLECL-TLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLL 681 Query: 663 VN--GETQQNTDSDSYTLKLGGYASVVFKLGN 692 + G + T+ T+ + G +V+ L + Sbjct: 682 CDPSGFQEDPTEIKK-TVAVNGIGTVILYLAS 712 >1UD8-A nrPDB Length = 480 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 57/153 (37%), Gaps = 20/153 (13%) Query: 73 DSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS-----YHGYDVTDYTK------ 121 ++DG + L+ L + G+ A+W+ P + S Y YD+ D + Sbjct: 16 ENDGQHWNRLHDDAAAL---SDAGITAIWIPPAYKGNSQADVGYGAYDLYDLGEFNQKGT 72 Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHT--GTAHPWFTEASSSSESPYRN---Y 176 V + GT++ +R + + I +Y D VMNH + + +++ Sbjct: 73 VRTKYGTKAQLERAIGSLKSNDINVYGDVVMNHKMGADFTEAVQAVQVNPTNRWQDISGA 132 Query: 177 YSFSEDPKTDIAAGKIAMITQE-GAAGYNAAEW 208 Y+ D + A + +N +W Sbjct: 133 YTIDAWTGFDFSGRNNAYSDFKWRWFHFNGVDW 165 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 35/215 (16%), Positives = 67/215 (31%), Gaps = 27/215 (12%) Query: 330 NIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIAR-GVDGLRLD 388 N D + Y + F + D + +DG RLD Sbjct: 183 NWRVDEENGNYDYLLGSNIDF-----------SHPEVQDELKDWGSWFTDELDLDGYRLD 231 Query: 389 AVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPA 448 A+KHI TS+ +++ + + D +++GE + +Y Sbjct: 232 AIKHIPFWYTSD----WVRHQRNEAD---------QDLFVVGEYWKDDVGALEFYLDEMN 278 Query: 449 LFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED--RTSSKL 506 F L + ++ + D+ + + T + NHD + Sbjct: 279 WEMSLFDVPLNYNFYRASQQGGSYDMRNILRGSLVEAHPMHAVTFVDNHDTQPGESLESW 338 Query: 507 GKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTK 541 K A +L G+P ++YG+ G+ Sbjct: 339 VADWFKPLAYATILTREGGYPNVFYGDYYGIPNDN 373 >2WAN-A nrPDB Length = 921 Score = 65.9 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 45/131 (34%), Gaps = 30/131 (22%) Query: 55 DETKRADISYQLLLYSF---ADSDGDGYGDLNGVTQK-----------LDYLNQLGVKAL 100 ++ Y+ + F A+S G T+ +D L +LG+ + Sbjct: 427 PANPVDEVIYEAHVRDFSIDANSGMKNKGKYLAFTEHGTKGPDHVKTGIDSLKELGITTV 486 Query: 101 WLSPIHPCMS---------YHGYDVTDYTKVNPQLGT-------ESDFDRLVTEAHNRGI 144 L P+ S GYD +Y T ++ +L+ H + I Sbjct: 487 QLQPVEEFNSIDETQPDTYNWGYDPRNYNVPEGAYATTPEGTARITELKQLIQSLHQQRI 546 Query: 145 KIYLDYVMNHT 155 + +D V NHT Sbjct: 547 GVNMDVVYNHT 557 Score = 65.9 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 57/386 (14%), Positives = 109/386 (28%), Gaps = 50/386 (12%) Query: 308 SSSSEKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNY------GPVDQA 361 S +++ +N D + + FD Y++ NY G Sbjct: 540 SLHQQRIGVNMDVVYNHTFDVMVSDFDKIVPQYYYRTDSNG-----NYTNGSGCGNEFAT 594 Query: 362 GESPAYQAIADAAKGWI-ARGVDGLRLDAVKHIYHS-------------ETSEENPRFLK 407 A + + D+ W+ VDG R D + + Sbjct: 595 EHPMAQKFVLDSVNYWVNEYHVDGFRFDLMALLGKDTMAKISNELHAINPGIVLYGEPWT 654 Query: 408 MFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTG 467 +++ IG F+ + + + Sbjct: 655 GGTSGLSSDQLVTKGQQKGLGIGVFNDNIRNGLDGNVFDKTAQGFATGDPNQVDVIKNGV 714 Query: 468 CYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHP 527 +D S + NY + + T S +LA AV+ TS G P Sbjct: 715 IGSIQDFTSAPSETINYVTSHDNMTLWDKILASNPSDTEADRIKMDELAHAVVFTSQGVP 774 Query: 528 YIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSL 587 ++ GEE + TK D +SY + ++A + Sbjct: 775 FMQGGEE--MLRTKGGND----------NSYNAGDSVNQFDW---------SRKAQFKDV 813 Query: 588 LNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDN----EKLLVIHN 643 + + S+ LRN +PA + E +A N + ++V++N Sbjct: 814 FDYFSSMIHLRNQHPAFRMTTADQIKQNLTFLESPTNTVAFELKNYANHDTWKNIIVMYN 873 Query: 644 FGGTAMQLPLTDKIEKVLFVNGETQQ 669 T+ L L ++ + + + Sbjct: 874 PNKTSQTLNLPSGDWTIVGLGDQIGE 899 >5CLW-A nrPDB Length = 668 Score = 64.8 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 2/87 (2%) Query: 89 LDYLNQLGVKALWLSPI--HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 L + LG + L I H + GY +T + + + G+ + LV AH+ GI + Sbjct: 192 LPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGSPEELQELVDTAHSMGIIV 251 Query: 147 YLDYVMNHTGTAHPWFTEASSSSESPY 173 LD V +H ++S Y Sbjct: 252 LLDVVHSHASKNSADGLNMFDGTDSCY 278 Score = 38.6 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 97/305 (31%), Gaps = 36/305 (11%) Query: 256 AKYLYYGEDICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLA 315 A Y ++ ++ + G N +L E + SF+ + ++YG+ ++L Sbjct: 182 ASYKHFTCNVLPRIKGLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGSPEELQELV 241 Query: 316 -------------LNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAG 362 + N+ + N MFD YFHS DL + A Sbjct: 242 DTAHSMGIIVLLDVVHSHASKNSADGLN-MFDGTDSCYFHS--GPRGTHDL-WDSRLFAY 297 Query: 363 ES-PAYQAIADAAKGWIAR-GVDGLRLDAVKHI---YHSETSEENPRFLKMFYEDMNAYY 417 S + + + W+ DG R D V + +H + + + F ++ Sbjct: 298 SSWEVLRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYSEYFGLQVDEDA 357 Query: 418 KQKGHTDDFYMIGEVLSEYDKVAPYYKGLPAL----------FEFSFWYRL--EWGINNS 465 + +++ + + +A G+PAL F++ + +W Sbjct: 358 LTYLMLAN-HLVHTLCPDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLK 416 Query: 466 TGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSK-LGKSADKCKLAAAVLLTSA 524 ++ N R +HD+ K L ++ + + + Sbjct: 417 EFKDEDWNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMSVLTP 476 Query: 525 GHPYI 529 P I Sbjct: 477 FTPVI 481 >1TMQ-A nrPDB Length = 471 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 63/200 (31%), Gaps = 25/200 (12%) Query: 352 DLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYE 411 DLN G + D I GV G R+DA KH+ + S + + Sbjct: 155 DLNQGSDY------VRGVLIDYMNHMIDLGVAGFRVDAAKHMSPGDLSVIFSGLKNLNTD 208 Query: 412 DMNAYYKQKGHTDDFY-MIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYF 470 A + + + GE +S+ Y G + EF F L Sbjct: 209 YGFADGARPFIYQEVIDLGGEAISK-----NEYTGFGCVLEFQFGVSLGNAFQGGNQ--- 260 Query: 471 AKDILSYQQKYANYRSDYIEATKLSNHDEDRTSS---KLGKSADKCKLAAAVLLTSAGHP 527 K++ ++ ++ + NHD RT K+ K+A A +L Sbjct: 261 LKNLANWGPEWG-LLEGLDAVVFVDNHDNQRTGGSQILTYKNPKPYKMAIAFMLAHP--- 316 Query: 528 YIYYGEELGLYGTKDNGDEY 547 YG + ++ Sbjct: 317 ---YGTTRIMSSFDFTDNDQ 333 Score = 39.3 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 8/81 (9%) Query: 82 LNGVTQKLD-YLNQLGVKALWLSPIHPCMSYHG------YDVTDYTKVNPQLGTESDFDR 134 N + + + +L G + +SP + + G Y Y +N + G ES F Sbjct: 21 WNDIADECERFLQPQGFGGVQISPPNEYLVADGRPWWERYQPVSYI-INTRSGDESAFTD 79 Query: 135 LVTEAHNRGIKIYLDYVMNHT 155 + ++ G++IY+D V+NH Sbjct: 80 MTRRCNDAGVRIYVDAVINHM 100 >3AMK-A nrPDB Length = 702 Score = 59.4 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 45/124 (36%), Gaps = 5/124 (4%) Query: 58 KRADISYQLLLYSFADSDGDGYGDLNGVTQK-LDYLNQLGVKALWLSPI--HPCMSYHGY 114 A Y+ + + L + + L I H + GY Sbjct: 178 PDAPRIYEAHVG--MSGEEPEVSTYREFADNVLPRIRANNYNTVQLMAIMEHSYYASFGY 235 Query: 115 DVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYR 174 VT++ V+ + GT D LV +AH+ G+++ +D V +H ++ + Sbjct: 236 HVTNFFAVSSRSGTPEDLKYLVDKAHSLGLRVLMDVVHSHASNNVTDGLNGYDVGQNTHE 295 Query: 175 NYYS 178 +Y+ Sbjct: 296 SYFH 299 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 51/174 (29%), Gaps = 24/174 (13%) Query: 341 FHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGV-DGLRLDAV-KHIYHSET 398 +H + + F N+ + + + W+ + DG R D V +YH Sbjct: 305 YHKLWDSRLFNYANW---------EVLRFLLSNLRYWMDEFMFDGFRFDGVTSMLYHHHG 355 Query: 399 SEENPRF-LKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPAL-------- 449 + K ++ +++ ++L E VA G+P L Sbjct: 356 INKGFTGNYKEYFSLDTDVDAIVYMMLANHLMHKLLPEATIVAEDVSGMPVLCRPVDEGG 415 Query: 450 --FEFSFWYRL--EWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDE 499 F+F + W + Q N R +HD+ Sbjct: 416 VGFDFRLAMAIPDRWIDYLKNKEDRKWSMSEIVQTLTNRRYTEKCIAYAESHDQ 469 >1GJU-A nrPDB Length = 637 Score = 58.6 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 54/159 (33%), Gaps = 37/159 (23%) Query: 55 DETKRADISYQLLLYSFADSDGDGYG-----DLNGVTQK---------LDYLNQLGVKAL 100 + + + Y L + A + G G D+ G + L ++ LG A+ Sbjct: 78 PDWIKRSVVYGSLPRTTAAYNHKGSGYYEENDVLGFREAGTFFKMMLLLPFVKSLGADAI 137 Query: 101 WLSPIHPCMSYHG-------YDVTDYTKVNPQLGTE--------SDFDRLVTEAHNRGIK 145 +L P+ Y V + +++ + +F V H GI+ Sbjct: 138 YLLPVSRMSDLFKKGDAPSPYSVKNPMELDERYHDPLLEPFKVDEEFKAFVEACHILGIR 197 Query: 146 IYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPK 184 + LD++ ++ E P +++ + + + Sbjct: 198 VILDFIP------RTAARDSDLIREHP--DWFYWIKVEE 228 Score = 52.8 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 46/301 (15%), Positives = 88/301 (29%), Gaps = 51/301 (16%) Query: 358 VDQAGESPAYQAIADAAKGWIAR-GVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAY 416 + ++ +A + + G+DG RLD K + + Sbjct: 354 PGKEPNRELWEYLAGVIPHYQKKYGIDGARLD------------MGHALPKELLDLI--I 399 Query: 417 YKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILS 476 K + F MI E L A G + S W ++ Sbjct: 400 KNVKEYDPAFVMIAEELDMEKDKASKEAGYDVILGSS------WYFAGRVEEIGKLPDIA 453 Query: 477 YQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGH-PYIYYGEEL 535 + S D R +++ S K KLA V PY+ G+E+ Sbjct: 454 EELVLPFLASVETP-------DTPRIATRKYASKMK-KLAPFVTYFLPNSIPYVNTGQEI 505 Query: 536 G----LYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIY 591 G + D D +R + D + + D + +LN Sbjct: 506 GEKQPMNLGLDT-DPNLRKVLSPTDEFFGKLA------FFDHYVLHWD--SPDRGVLNFI 556 Query: 592 FSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQL 651 L ++R+ + + + K + + K+ +K+++ N G ++ Sbjct: 557 KKLIKVRHE--------FLDFVLNGKFENLTTKDLVMYSYEKNGQKIVIAANVGKEPKEI 608 Query: 652 P 652 Sbjct: 609 T 609 >1BPL-B nrPDB Length = 294 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 41/193 (21%), Positives = 64/193 (33%), Gaps = 20/193 (10%) Query: 350 FADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMF 409 +AD++Y D A E + +DG RLDAVKHI F Sbjct: 9 YADIDYDHPDVAAEIKRWGTWYAN-----ELQLDGFRLDAVKHIKF------------SF 51 Query: 410 YEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCY 469 D + ++K + + + E Y F L + + ++ Sbjct: 52 LRDWVNHVREKTGK-EMFTVAEYWQNDLGALENYLNKTNFNHSVFDVPLHYQFHAASTQG 110 Query: 470 FAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCK-LAAAVLLTSA-GHP 527 D+ + T + NHD S K LA A +LT G+P Sbjct: 111 GGYDMRKLLNSTVVSKHPLKAVTFVDNHDTQPGQSLESTVQTWFKPLAYAFILTRESGYP 170 Query: 528 YIYYGEELGLYGT 540 ++YG+ G G Sbjct: 171 QVFYGDMYGTKGD 183 >3VM5-A nrPDB Length = 505 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 49/167 (29%), Gaps = 17/167 (10%) Query: 366 AYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDD 425 +AD I GV G R+DA KH++ + ++ N K Sbjct: 175 VRGKVADFMNKLIDMGVAGFRVDACKHMWPGD-------LDNVYRRLNNLNTKWFPGGSR 227 Query: 426 FYMIGEV--LSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYAN 483 ++ EV L Y GL + EF + RL G + Sbjct: 228 PFIFQEVIDLGGEPITTGEYVGLGRVTEFKYGARLGELFRKWNGQ--KLSYTKNWGEGWG 285 Query: 484 YRSDYIEATKLSNHDEDRTSSKLGK------SADKCKLAAAVLLTSA 524 + +D NHD R G K+A +L Sbjct: 286 FMADGNAVVFTDNHDNQRGHGAGGASILTFWDPRLYKMAVGYMLAHP 332 Score = 34.3 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 28/136 (20%), Positives = 51/136 (37%), Gaps = 30/136 (22%) Query: 96 GVKALWLSPIHP---CMSYHGYDVTDYTKVNPQL----GTESDFDRLVTEAHNRGIKIYL 148 G + +SP + S Y ++ L G E++ ++T +N G+ +Y+ Sbjct: 36 GFAGVQISPPNEHILVSSPWRPWWQRYQPISYNLCSRSGGENELRDMITRCNNVGVNVYV 95 Query: 149 DYVMNHT----------GTAHPWFTEASSSSESPYRNYYSF-SEDPKTDIAAGKIAMITQ 197 D V+NH + WF +++ + P Y + D K +G I Sbjct: 96 DAVINHMCGAGGGEGTHSSCGSWFN--ANNKDFPSVPYSNLDFNDGKCKTGSGNIE---- 149 Query: 198 EGAAGYNAAEWFQVSD 213 N + +QV D Sbjct: 150 ------NYGDPYQVRD 159 >1MFU-A nrPDB Length = 491 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 89/283 (31%), Gaps = 36/283 (12%) Query: 366 AYQAIADAAKGWIARGVDGLRLDAVKHIYHSE---TSEENPRFLKMFYEDMNAYYKQKGH 422 IA+ I GV G R+DA KH++ + ++ ++ + + + + Sbjct: 175 VRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLNSNWFPEGSKPFIYQEV 234 Query: 423 TDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYA 482 D + GE + D Y G + EF + +L I G L + Sbjct: 235 ID---LGGEPIKSSD-----YFGNGRVTEFKYGAKLGTVIRKWNGE--KMSYLKNWGEGW 284 Query: 483 NYRSDYIEATKLSNHDEDRTSSKLGK-SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTK 541 + + NHD R S L A K+A +L YG + + Sbjct: 285 GFMPSDRALVFVDNHDNQRGHSILTFWDARLYKMAVGFMLAHP------YGFTRVMSSYR 338 Query: 542 DN-GDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNT 600 E + W N K T++ + D + ++ RN Sbjct: 339 WPRYFENGKDVNDWVGPPNDNGVTKE-VTINPDTTCGNDWVCEHR--WRQIRNMVNFRN- 394 Query: 601 YPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 + +G + N S + A+ N +V +N Sbjct: 395 ---VVDGQPFTNWYDNGSNQ------VAFGR--GNRGFIVFNN 426 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 9/73 (12%) Query: 91 YLNQLGVKALWLSPIHPCMSYH--------GYDVTDYTKVNPQLGTESDFDRLVTEAHNR 142 YL G + +SP + ++ H Y Y K+ + G E +F +VT +N Sbjct: 31 YLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSY-KLCTRSGNEDEFRNMVTRCNNV 89 Query: 143 GIKIYLDYVMNHT 155 G++IY+D V+NH Sbjct: 90 GVRIYVDAVINHM 102 >1UA7-A nrPDB Length = 422 Score = 54.4 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 25/90 (27%), Positives = 37/90 (41%), Gaps = 11/90 (12%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIHPCMS-----------YHGYDVTDYTKVNPQLGTES 130 N + + ++ G A+ SPI+ Y Y T Y N LGTE Sbjct: 16 FNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWLYQPTSYQIGNRYLGTEQ 75 Query: 131 DFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 +F + A GIK+ +D V+NHT + Sbjct: 76 EFKEMCAAAEEYGIKVIVDAVINHTTFDYA 105 Score = 45.5 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 38/223 (17%), Positives = 70/223 (31%), Gaps = 31/223 (13%) Query: 330 NIMFDSQQITYFH-SHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLD 388 N + QI + T L + + + + G DG R D Sbjct: 116 NWTHGNTQIKNWSDRWDVTQNS--LLGLYDWNTQNTQVQSYLKRFLERALNDGADGFRFD 173 Query: 389 AVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPA 448 A KHI ++ + F+ ++ + + GE+L + Y Sbjct: 174 AAKHI----ELPDDGSYGSQFWPNITNTSAE-------FQYGEILQDSASRDAAYANYMD 222 Query: 449 LFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIE---ATKLSNHDE---DRT 502 + ++ + + + N ++Y SD T + +HD D Sbjct: 223 VTASNYGHSIRSALKNRNLGV---------SNISHYASDVSADKLVTWVESHDTYANDDE 273 Query: 503 SSKLGKSADKCKLAAAVLLTSAG-HPYIYYGEELGLYGTKDNG 544 S D +L AV+ + +G P + E G G + G Sbjct: 274 ESTWMSDDD-IRLGWAVIASRSGSTPLFFSRPEGGGNGVRFPG 315 >3DC0-A nrPDB Length = 422 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 11/90 (12%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIHPCMS-----------YHGYDVTDYTKVNPQLGTES 130 N + + ++ G A+ SPI+ Y Y T Y N LG+E Sbjct: 16 FNTLKNNMKDIHDAGYTAIQTSPINQVKEGNKGDKSMGNWYWLYQPTSYQIGNRYLGSEE 75 Query: 131 DFDRLVTEAHNRGIKIYLDYVMNHTGTAHP 160 +F + A G+K+ +D V+NHT + + Sbjct: 76 EFKEMCAAAEEYGVKVIVDAVINHTTSDYA 105 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 26/175 (14%), Positives = 53/175 (30%), Gaps = 26/175 (14%) Query: 329 ANIMFDSQQITYFH-SHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRL 387 +N + QI + T L + + + + G DG R Sbjct: 115 SNWTHGNTQIKNWSDRWDVTQNS--LLGLYDWNTQNTQVQSYLKRFLERALNDGADGFRY 172 Query: 388 DAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLP 447 DA KHI ++ + F+ ++ + + GE+L + Y Sbjct: 173 DAAKHI----ELPDDGNYGSQFWPNITNTSAE-------FQYGEILQDSASRDAAYANYM 221 Query: 448 ALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIE---ATKLSNHDE 499 + ++ + + + N ++Y SD T + +HD Sbjct: 222 NVTASNYGHSIRSALKNRNLSV---------SNISHYASDVSADKLVTWVESHDT 267 >3AIC-A nrPDB Length = 844 Score = 51.3 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 35/84 (41%), Gaps = 13/84 (15%) Query: 85 VTQKLDYLNQLGVKALWLSPIHPCMSY---------HGYDVTDYTKVN----PQLGTESD 131 + + +D + GV ++P + + +GY TD + + GT D Sbjct: 635 IAKNVDKFAEWGVTDFEMAPQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADD 694 Query: 132 FDRLVTEAHNRGIKIYLDYVMNHT 155 + + H++GIK+ D+V + Sbjct: 695 LVKAIKALHSKGIKVMADWVPDQM 718 >5C8B-B nrPDB Length = 514 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 8/107 (7%) Query: 74 SDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMS--YHGYDVTDYTKVNPQLGTESD 131 +D G G + +T L + + P G+D D+TKV+ +LG+ D Sbjct: 13 ADRLGDGTIKSMTDILRTRFDGVYDGVHILPFFTPFDGADAGFDPIDHTKVDERLGSWDD 72 Query: 132 FDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEA-SSSSESPYRNYY 177 L ++ HN I +D ++NH F + + ES Y + Sbjct: 73 VAEL-SKTHN----IMVDAIVNHMSWESKQFQDVLAKGEESEYYPMF 114 >3L2M-A nrPDB Length = 496 Score = 48.6 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 53/325 (16%), Positives = 95/325 (29%), Gaps = 36/325 (11%) Query: 356 GPVDQAGESPAYQAIA-DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMN 414 G +D A E +++ D I GV G R+DA KH+ + L + Sbjct: 164 GLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHM----WPGDIKAVLDKLHNLNT 219 Query: 415 AYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDI 474 ++ F + ++ E + + Y+ G + EF + +L + +G Sbjct: 220 NWFPAGSRPFIFQEVIDLGGEAIQSSEYF-GNGRVTEFKYGAKLGTVVRKWSGE--KMSY 276 Query: 475 LSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGK------SADKCKLAAAVLLTSAGHPY 528 L + + + NHD R G A K+A +L Sbjct: 277 LKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHP---- 332 Query: 529 IYYGEELGLYGTKD-----NGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQAD 583 YG + + NG + W N K V+ N T Sbjct: 333 --YGFTRVMSSYRWARNFVNGQDVN----DWIGPPNNNGVIKE---VTINADTTCGNDWV 383 Query: 584 THSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHN 643 ++ RN + +G + N S + + ++ +N+ + Sbjct: 384 CEHRWRQIRNMVWFRN----VVDGQPFANWWDNGSNQVAFGRGNRGFIVFNNDDWQLSST 439 Query: 644 FGGTAMQLPLTDKIEKVLFVNGETQ 668 D I N T Sbjct: 440 LQTGLPGGTYCDVISGDKVGNSCTG 464 Score = 37.4 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 9/73 (12%) Query: 91 YLNQLGVKALWLSPIHPC--------MSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNR 142 YL G + +SP + + Y Y K+ + G E++F +VT +N Sbjct: 31 YLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSY-KLCTRSGNENEFRDMVTRCNNV 89 Query: 143 GIKIYLDYVMNHT 155 G++IY+D V+NH Sbjct: 90 GVRIYVDAVINHM 102 >5JBE-A nrPDB Length = 854 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 34/83 (40%), Gaps = 9/83 (10%) Query: 82 LNGVTQKLDYLNQLGVKALWLSPIH----PCMSYHGYDVTDYTKV----NP-QLGTESDF 132 N + + + LG+ W++P + GY +TD + NP + G+ + Sbjct: 643 YNVIAKNASLFSDLGITDFWMAPAYTPFGRSRYNEGYSMTDRYNLGTTANPTKYGSGEEL 702 Query: 133 DRLVTEAHNRGIKIYLDYVMNHT 155 + H G+K+ D VMN Sbjct: 703 ANTIAALHKAGLKVQEDIVMNQM 725 Score = 33.6 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 63/216 (29%), Gaps = 24/216 (11%) Query: 304 KYGASSSSEKLALNKDFKLTNAGNPA----NIMFDSQQITYFHSHFCTDWFADLNYGPVD 359 K G S + + +N + K GN + N ++ I + +D +L G Sbjct: 157 KSGTIDSDQVIFVNNNSKDPRKGNTSYADSNYRLMNRTINNQAGNNNSDNSPELLVGNDI 216 Query: 360 QAGESPAYQAIADAAKGWIARG----------VDGLRLDAVKHIYHSETSEENPRFLKMF 409 + + G DG R+DA +I + + Sbjct: 217 DNSNPVVQAENLNWEYFLLNYGKLMGYNPDGNFDGFRVDAADNIDADVLDQ-----MGQL 271 Query: 410 YEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPAL-FEFSFWYRLEWGI----NN 464 DM + +D E KG P L + +Y LE + N Sbjct: 272 MNDMYHTKGNPQNANDHLSYNEGYHSGAAQMLNEKGNPQLYMDSGEFYTLENVLGRANNR 331 Query: 465 STGCYFAKDILSYQQKYANYRSDYIEATKLSNHDED 500 + + +Q + ++NHD+ Sbjct: 332 DNIGNLITNSIVNRQNDTTENEATPNWSFVTNHDQR 367 >1JD7-A nrPDB Length = 453 Score = 46.3 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 66/239 (27%), Gaps = 41/239 (17%) Query: 318 KDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGW 377 +DF + N ++ D ++ D NY A QAI Sbjct: 114 QDFHESCTINNSDYGNDRYRVQNCELVGLADLDTASNYVQNTIAAYINDLQAI------- 166 Query: 378 IARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYD 437 GV G R DA KH+ S+ ++ +N D GE + Sbjct: 167 ---GVKGFRFDASKHVAASD--------IQSLMAKVNGSPVVFQEVID--QGGEAVG--- 210 Query: 438 KVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNH 497 A Y + EF + L N + + S + + + NH Sbjct: 211 --ASEYLSTGLVTEFKYSTELGNTFRNGSLAWL-----SNFGEGWGFMPSSSAVVFVDNH 263 Query: 498 DEDRTSSKLGK-----SADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSP 551 D R G LA +L YG + +GD P Sbjct: 264 DNQRGHGGAGNVITFEDGRLYDLANVFMLAYP------YGYPRVMSSYDFHGDTDAGGP 316 Score = 34.7 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 5/70 (7%) Query: 91 YLNQLGVKALWLSP----IHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKI 146 YL G A+ +SP I + Y Y ++ + G + F +V G+ I Sbjct: 23 YLGPKGYAAVQVSPPNEHITGSQWWTRYQPVSY-ELQSRGGNRAQFIDMVNRCSAAGVDI 81 Query: 147 YLDYVMNHTG 156 Y+D ++NH Sbjct: 82 YVDTLINHMA 91 >1GCY-A nrPDB Length = 527 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 29/76 (38%), Gaps = 13/76 (17%) Query: 96 GVKALWLSPI-----------HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGI 144 G A+W P+ GY D+ K N + G+++ + + G+ Sbjct: 50 GFSAIW-MPVPWRDFSSWSDGSKSGGGEGYFWHDFNK-NGRYGSDAQLRQAASALGGAGV 107 Query: 145 KIYLDYVMNHTGTAHP 160 K+ D V NH +P Sbjct: 108 KVLYDVVPNHMNRGYP 123 Score = 42.8 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 53/176 (30%), Gaps = 39/176 (22%) Query: 380 RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLS----- 434 G G R D F++ + + D+ + +GE+ Sbjct: 185 YGAGGFRFD----------------FVRGYAPERVN-SWMTDSADNSFCVGELWKGPSEY 227 Query: 435 ---EYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 ++ A + + + + + ++ + D + R + Sbjct: 228 PNWDWRNTASWQQIIKDWSDRAKCPVFDFALKERMQNGSIADWKHGLNGNPDPRWREVAV 287 Query: 492 TKLSNHDEDRTSSKLGKSAD------KCKLAAAVLLTSAGHPYIY--------YGE 533 T + NHD + + G + A A +LTS G P +Y YG+ Sbjct: 288 TFVDNHDTGYSPGQNGGQHHWALQDGLIRQAYAYILTSPGTPVVYWDHMYDWGYGD 343 >1QI5-A nrPDB Length = 429 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 29/76 (38%), Gaps = 13/76 (17%) Query: 96 GVKALWLSPI-----------HPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGI 144 G A+W P+ GY D+ K N + G+++ + + G+ Sbjct: 50 GFSAIW-MPVPWRDFSSWSDGSKSGGGEGYFWHDFNK-NGRYGSDAQLRQAASALGGAGV 107 Query: 145 KIYLDYVMNHTGTAHP 160 K+ D V NH +P Sbjct: 108 KVLYDVVPNHMNRGYP 123 Score = 38.9 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 25/176 (14%), Positives = 53/176 (30%), Gaps = 39/176 (22%) Query: 380 RGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLS----- 434 G G R D F++ + + D+ + +GE+ Sbjct: 185 YGAGGFRFD----------------FVRGYAPERVN-SWMTDSADNSFCVGELWKGPSEY 227 Query: 435 ---EYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEA 491 ++ A + + + + + ++ + D + R + Sbjct: 228 PNWDWRNTASWQQIIKDWSDRAKCPVFDFALKERMQNGSIADWKHGLNGNPDPRWREVAV 287 Query: 492 TKLSNHDEDRTSSKLGKSAD------KCKLAAAVLLTSAGHPYIY--------YGE 533 T + NH+ + + G + A A +LTS G P +Y YG+ Sbjct: 288 TFVDNHNTGYSPGQNGGQHHWALQDGLIRQAYAYILTSPGTPVVYWDHMYDWGYGD 343 >4J3X-A nrPDB Length = 905 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 21/149 (14%), Positives = 40/149 (26%), Gaps = 57/149 (38%) Query: 63 SYQLLLYSFADSDG----DGYGDLNGVT-------QKLDYLNQLGVKALWLSPIHPCMS- 110 Y+L + F+ DG D G + L L+ G+ + L P Sbjct: 276 IYELHIRDFSAHDGTVDSDSRGGFRAFAYQASAGMEHLRKLSDAGLTHVHLLPSFHFAGV 335 Query: 111 --------------------------------------YHGYDVTDYTKVNPQLGTESD- 131 GY+ + ++ D Sbjct: 336 DDIKSNWKFVDECELATFPPGSDMQQAAVVAIQEEDPYNWGYNPVLWGVPKGSYASDPDG 395 Query: 132 ------FDRLVTEAHNRGIKIYLDYVMNH 154 + ++V + G+++ +D V NH Sbjct: 396 PSRIIEYRQMVQALNRIGLRVVMDVVYNH 424 Score = 30.1 bits (66), Expect = 3.9, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 26/76 (34%), Gaps = 7/76 (9%) Query: 372 DAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGE 431 D + VDG R D + HI L+ D + K Y+ G Sbjct: 477 DLLNWAVNYKVDGFRFDLMGHIMKRTMMRAKSA-LQSLTTDAHGVDGSK-----IYLYGA 530 Query: 432 VLSEYDKVAPYYKGLP 447 ++ +VA +G+ Sbjct: 531 GW-DFAEVARNQRGIN 545 >5X3I-A nrPDB Length = 743 Score = 33.9 bits (76), Expect = 0.25, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 21/55 (38%), Gaps = 2/55 (3%) Query: 94 QLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL 148 + G+ +W ++ + P G D ++ E H RGIK+ L Sbjct: 339 EQGIT-IWRDAVYAVTEDGSAHRAEDFSYRPD-GAWPDPKAMIDELHARGIKVIL 391 >4H54-A nrPDB Length = 304 Score = 33.6 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 29/79 (36%), Gaps = 9/79 (11%) Query: 107 PCMSYHGYDVTDYTKVNPQLGTESD----FDRLVTEAHNR----GIKIYLDYVMNHTGTA 158 H Y + + + LG + + RL+ AH G ++ L V NH A Sbjct: 42 EITDNHSYGLAQFGRWIDHLGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDA 101 Query: 159 HP-WFTEASSSSESPYRNY 176 H F E S + +Y Sbjct: 102 HFDAFQEGLLSFTAALTDY 120 >5Z01-A nrPDB Length = 323 Score = 33.2 bits (74), Expect = 0.42, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 45/133 (33%), Gaps = 5/133 (3%) Query: 553 LWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRN-----TYPALAEG 607 LWG + + + K + + + L +L + A+ G Sbjct: 191 LWGGNLAMLISLIGTPWMPKIENGILVLEDINEHPFRVERMLLQLYHAGILPRQKAIILG 250 Query: 608 NMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGET 667 + + + + + + + A+ ++ + L+ +FG + L +L E Sbjct: 251 SFSGSTPNDYDAGYNLESVYAFLRSRLSIPLITGLDFGHEQRTVTLPLGAHAILNNTREG 310 Query: 668 QQNTDSDSYTLKL 680 Q T S LK+ Sbjct: 311 TQLTISGHPVLKM 323 >2CKS-A nrPDB Length = 306 Score = 33.2 bits (74), Expect = 0.44, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 30/77 (38%), Gaps = 8/77 (10%) Query: 114 YDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAH-------PWFTEAS 166 Y D + NP+ G +L+ A RG+ + +D+ + G H +F E + Sbjct: 65 YIQEDGYETNPR-GFTDRMHQLIDMATARGLYVIVDWHILTPGDPHYNLDRAKTFFAEIA 123 Query: 167 SSSESPYRNYYSFSEDP 183 S Y + +P Sbjct: 124 QRHASKTNVLYEIANEP 140 >5CQF-A nrPDB Length = 443 Score = 32.8 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 19/57 (33%), Gaps = 2/57 (3%) Query: 320 FKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAG--ESPAYQAIADAA 374 FKLT G N +F + YFHS L++ + Q + Sbjct: 241 FKLTQLGQFPNRVFAPDHVDYFHSLNPAARQRFLDWSRSTNYAGIDPDERQKLFSLI 297 >2HVA-A nrPDB Length = 192 Score = 32.8 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 20/54 (37%), Gaps = 3/54 (5%) Query: 504 SKLGKSADKCK-LAAAVLL--TSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLW 554 ++ G A + +A A L T G P Y G+ G Y R +W Sbjct: 135 TQFGGYAKEADYVAHATQLRTTLEGTPATYQGDVYYCAGYDPPMKPYGRRNEVW 188 >3J9M-AO nrPDB Length = 258 Score = 32.4 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 12/91 (13%), Positives = 34/91 (37%), Gaps = 13/91 (14%) Query: 132 FDRLVTEAHNRGIKIY---------LDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSED 182 + + +A + G+ IY LD+ +H + S + P+ +Y++ + Sbjct: 150 LTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGD-PWYPWYNWKQP 208 Query: 183 PKTDIAAGKIAM---ITQEGAAGYNAAEWFQ 210 P+ +++ + + +E + Sbjct: 209 PERELSRLRRLYQGHLQEESGPPPESMPKMP 239 >3DUG-A nrPDB Length = 408 Score = 32.0 bits (71), Expect = 0.87, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 15/26 (57%) Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKI 146 VN + T + +V EAHN G+K+ Sbjct: 197 DVNAKQFTLEEMKAIVDEAHNHGMKV 222 >4ML9-A nrPDB Length = 286 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 30/93 (32%), Gaps = 8/93 (8%) Query: 122 VNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSE 181 V+ T D +V AH G+ +D + H H + A + E + Sbjct: 139 VHIHKSTLEDLKDVVKYAHKYGL--LVDAYIGHPDDLHTFGISARTPEEVAE------AA 190 Query: 182 DPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDE 214 I I ++T G A E V E Sbjct: 191 KEMEKIGVDMIGLMTGMSYEGTAAGEIHPVIKE 223 >6MDV-A nrPDB Length = 802 Score = 31.6 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 33/142 (23%), Positives = 48/142 (33%), Gaps = 14/142 (9%) Query: 343 SHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEEN 402 + + D G A AI A RGVDGL +D + T EE+ Sbjct: 105 RTGLSKDYPDTPEGNKALAA------AIVKA--FVTDRGVDGLDIDIEHEFTNKRTPEED 156 Query: 403 PRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGI 462 R L +F E K ++ LS + P +KG+ ++ L Sbjct: 157 ARALNVFKEIAQLIGKNGSDKSKLLIMDTTLSV--ENNPIFKGIAEDLDY----LLRQYY 210 Query: 463 NNSTGCYFAKDILSYQQKYANY 484 + G I S +Y NY Sbjct: 211 GSQGGEAEVDTINSDWNQYQNY 232 >1QVB-A nrPDB Length = 481 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 42/105 (40%), Gaps = 3/105 (2%) Query: 144 IKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGY 203 +K D+++ ++ + F SE P +++ + DP+ + AAG ++ E GY Sbjct: 1 MKFPKDFMIGYSSSPFQ-FEAGIPGSEDPNSDWWVWVHDPE-NTAAGLVSGDFPENGPGY 58 Query: 204 NAAEWFQVSDETAAVKGLLKFTLDWSN-APSPILVVSTGTKADED 247 ++ ++WS P P V + DE+ Sbjct: 59 WNLNQNDHDLAEKLGVNTIRVGVEWSRIFPKPTFNVKVPVERDEN 103 >6MRE-A nrPDB Length = 420 Score = 31.2 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 3/37 (8%) Query: 121 KVNPQLGTESDFDRLVTEAHNRGIKIYLDY---VMNH 154 V+ LGTE+ ++T AH G K+ +D VM+H Sbjct: 186 HVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHH 222 >3POC-A nrPDB Length = 666 Score = 30.9 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 36/273 (13%), Positives = 77/273 (28%), Gaps = 29/273 (10%) Query: 363 ESPAYQAIADAAKGWIARGVDGL--RLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQK 420 A + D + I +G++G ++ Y SE E F F +D Sbjct: 285 NPEARKWFGDKYRFLIDQGIEGFWNAMNEPAIFYSSEGLAEAKEFAGEFAKDTEGKIHPW 344 Query: 421 GHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQK 480 I +Y + G + +G N + A + + +++ Sbjct: 345 AMQAKMKDIVNSPEDYKRFYHNVNGKKIRHDKVHNL---FGYNMTRAAGEAFERIDPEKR 401 Query: 481 YANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHP------YIYYGEE 534 + + ++ + H R + +LL P ++Y G + Sbjct: 402 FLMFSR----SSYIGMH---RYGGIWMGDNKSW--WSHILLNLKMLPSLNMCGFMYTGAD 452 Query: 535 LGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSL 594 LG +G D +R T + +Q+ + + S+ Sbjct: 453 LGGFGDDTTRDLLLR---------FLALGVFTPLMRDHAAEGTREQECYQFENIEDFRSV 503 Query: 595 TRLRNTYPALAEGNMTKHSVYNESQEKDYKPIA 627 R K ++ ++ K + Sbjct: 504 INARYRLVPYLYSEYMKAALNDDMYFKPLGFVY 536 >1WB0-A nrPDB Length = 445 Score = 30.9 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 34/91 (37%), Gaps = 9/91 (9%) Query: 18 AFMTACSDDKNITDPAPEPEPPVEGQWT-----ALTASPDTWDETKRADISYQLLLYSFA 72 +F A S D + PA P G +T +W + I Q + Y F Sbjct: 249 SFTLASSSDTRVGAPATGSGTP--GPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFR 306 Query: 73 DSDGDGYGDLNGVTQKLDYL--NQLGVKALW 101 D+ G+ D+ K+ YL LG +W Sbjct: 307 DNQWVGFDDVESFKTKVSYLKQKGLGGAMVW 337 >5WZN-A nrPDB Length = 640 Score = 30.9 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 28/88 (31%), Gaps = 25/88 (28%) Query: 92 LNQLGVKALWLSPIHPCMSYHGYDVT--DYTKVNPQLGTESDFDRLVTEAHNRGIKIYLD 149 L+++G L+L + GYD DY + G L+ H +G D Sbjct: 309 LHEMGAGRLYL--HLDGWAQPGYDNGHPDYLPACREAGGWKGMKSLIDACHEQG-----D 361 Query: 150 YVMNHTGTAHPWFTEASSSSESPYRNYY 177 H YR+YY Sbjct: 362 LFGTH----------------DQYRDYY 373 >4WKA-A nrPDB Length = 377 Score = 30.1 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 34/91 (37%), Gaps = 9/91 (9%) Query: 18 AFMTACSDDKNITDPAPEPEPPVEGQWT-----ALTASPDTWDETKRADISYQLLLYSFA 72 +F A S D + PA P G +T +W + I Q + Y F Sbjct: 249 SFTLASSSDTRVGAPATGSGTP--GPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFR 306 Query: 73 DSDGDGYGDLNGVTQKLDYL--NQLGVKALW 101 D+ G+ D+ K+ YL LG +W Sbjct: 307 DNQWVGFDDVESFKTKVSYLKQKGLGGAMVW 337 >4Q6X-A nrPDB Length = 301 Score = 29.3 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 35/95 (36%), Gaps = 7/95 (7%) Query: 102 LSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYL---DYVMNHTGTA 158 ++ M G+D Y K+ D ++ + GI+ ++ D + N Sbjct: 165 ITGFKDTMKKEGFDEKYYDKIGWDFSGNEDLGKIRDVLESHGIREHIWQGDGITNCLPRD 224 Query: 159 HPWFTEASSSSESPYRNY----YSFSEDPKTDIAA 189 +A S SP Y Y++S D ++ I Sbjct: 225 DNRLKQAISRRYSPTYVYADKVYTWSIDKESSIEN 259 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.129 0.370 Lambda K H 0.267 0.0397 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,107,071 Number of Sequences: 36641 Number of extensions: 1228043 Number of successful extensions: 3649 Number of sequences better than 10.0: 137 Number of HSP's better than 10.0 without gapping: 216 Number of HSP's successfully gapped in prelim test: 37 Number of HSP's that attempted gapping in prelim test: 2564 Number of HSP's gapped (non-prelim): 541 length of query: 692 length of database: 10,336,785 effective HSP length: 104 effective length of query: 588 effective length of database: 6,526,121 effective search space: 3837359148 effective search space used: 3837359148 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 62 (28.5 bits)