BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q86Z14 (1044 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5VAQ-A nrPDB 1985 0.0 5WI9-A nrPDB 962 0.0 5W21-A nrPDB 871 0.0 3VKK-A nrPDB 320 2e-87 1WCG-A nrPDB 295 6e-80 5YJ7-A nrPDB 290 3e-78 3WBE-A nrPDB 286 4e-77 3VIK-A nrPDB 277 2e-74 2RGL-A nrPDB 270 2e-72 4GXP-A nrPDB 268 9e-72 5CG0-A nrPDB 266 4e-71 1CBG-A nrPDB 262 6e-70 3PTM-A nrPDB 261 8e-70 2E40-A nrPDB 261 8e-70 4JIE-A nrPDB 261 2e-69 3WQ4-A nrPDB 259 5e-69 3ZJ8-A nrPDB 253 2e-67 2DGA-A nrPDB 253 3e-67 5JBO-A nrPDB 253 4e-67 3AIW-A nrPDB 250 2e-66 4A3Y-A nrPDB 249 3e-66 5OGZ-A nrPDB 248 7e-66 1V02-A nrPDB 248 1e-65 4MDP-A nrPDB 247 2e-65 3AHY-A nrPDB 246 3e-65 5IDI-A nrPDB 246 5e-65 5BWF-A nrPDB 244 1e-64 2CBU-A nrPDB 244 1e-64 3AHX-A nrPDB 233 3e-61 1E55-A nrPDB 231 1e-60 1BGG-A nrPDB 230 2e-60 1QOX-A nrPDB 228 1e-59 1W9D-M nrPDB 224 1e-58 4PTW-A nrPDB 212 7e-55 4ZEN-A nrPDB 207 3e-53 5XGZ-A nrPDB 206 5e-53 5GNX-A nrPDB 202 7e-52 5NS7-A nrPDB 199 8e-51 5WKA-A nrPDB 193 3e-49 2Z1S-A nrPDB 193 3e-49 3ZJK-A nrPDB 192 6e-49 5DT5-A nrPDB 192 6e-49 1GNX-A nrPDB 190 2e-48 5YHS-A nrPDB 189 5e-48 5AYI-A nrPDB 189 8e-48 4HZ6-A nrPDB 188 9e-48 3W53-A nrPDB 169 7e-42 4IPN-B nrPDB 153 4e-37 4F66-A nrPDB 151 1e-36 2XHY-A nrPDB 144 3e-34 5NAV-A nrPDB 138 1e-32 4GZE-A nrPDB 131 2e-30 4B3K-A nrPDB 126 5e-29 1PBG-A nrPDB 118 1e-26 4R27-A nrPDB 108 9e-24 1VFF-A nrPDB 96 1e-19 1QVB-A nrPDB 72 1e-12 3WDP-P nrPDB 70 4e-12 4HA4-A nrPDB 61 2e-09 1GOW-A nrPDB 48 2e-05 3ZPX-A nrPDB 32 1.7 2D7R-A nrPDB 31 2.7 >5VAQ-A nrPDB Length = 954 Score = 1985 bits (5143), Expect = 0.0, Method: Compositional matrix adjust. Identities = 952/954 (99%), Positives = 952/954 (99%) Query: 30 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI 89 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI Sbjct: 1 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI 60 Query: 90 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY 149 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY Sbjct: 61 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY 120 Query: 150 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW 209 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW Sbjct: 121 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW 180 Query: 210 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV 269 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV Sbjct: 181 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV 240 Query: 270 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGW 329 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEP RSENTMDIFKCQQSMVSVLGW Sbjct: 241 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQQSMVSVLGW 300 Query: 330 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG 389 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG Sbjct: 301 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG 360 Query: 390 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL 449 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL Sbjct: 361 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL 420 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS Sbjct: 421 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 480 Query: 510 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL 569 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL Sbjct: 481 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL 540 Query: 570 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSE 629 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTG LSAVNRQALRYYRCVVSE Sbjct: 541 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGQLSAVNRQALRYYRCVVSE 600 Query: 630 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI 689 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI Sbjct: 601 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI 660 Query: 690 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP Sbjct: 661 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 720 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA Sbjct: 721 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 780 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV Sbjct: 781 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 840 Query: 870 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 929 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY Sbjct: 841 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 900 Query: 930 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT 983 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT Sbjct: 901 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT 954 >5WI9-A nrPDB Length = 470 Score = 962 bits (2487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 457/457 (100%), Positives = 457/457 (100%) Query: 52 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD 111 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD Sbjct: 1 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD 60 Query: 112 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG 171 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG Sbjct: 61 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG 120 Query: 172 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD 231 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD Sbjct: 121 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD 180 Query: 232 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 291 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH Sbjct: 181 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 240 Query: 292 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 351 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV Sbjct: 241 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 300 Query: 352 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR 411 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR Sbjct: 301 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR 360 Query: 412 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA Sbjct: 361 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 420 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF Sbjct: 421 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 457 Score = 173 bits (439), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 130/483 (26%), Positives = 208/483 (43%), Gaps = 69/483 (14%) Query: 510 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL 569 + ES + FP +F WG+ L+ V S + +W+ + L V Sbjct: 19 VNESQLFLYDTFPKNFFWGIGTGALQ---VEGSWKKDGKGPSIWDHFIHTHLKNVSSTN- 74 Query: 570 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSE 629 ++ ++K L L + V+ Y+F++ W + P G ++ N + L+YY ++ Sbjct: 75 ----GSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 130 Query: 630 GLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLW 688 + I +VTLY H LP L GW N + + F YA CFQ GD VK W Sbjct: 131 LVLRNIEPIVTLY-----HWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYW 185 Query: 689 ITINEPNRLS--------DIYNRSGN--DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAV 738 ITI+ P ++ GN Y HNL+ AH+ W Y+ FRP Q+G + Sbjct: 186 ITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWL 245 Query: 739 SLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL 798 S++L + W EP ++ + + WFA P+ GDYP MR+ + Sbjct: 246 SITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLF------- 298 Query: 799 SSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSS 858 S LP +EAE+ ++GT DF A + F + L + ++ Sbjct: 299 --SVLPIFSEAEKHEMRGTADFFAFSFGPNNF-----------------KPLNTMAKMGQ 339 Query: 859 PTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG--IDDQALEDDRLRKYYLGKYLQEVLK 916 L +R+ L W++ Y + I I +G D + +D Y + +L +VL+ Sbjct: 340 NVSL-----NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQ 394 Query: 917 AYLIDKVRIKGYYAFKLA-----EEKSKPRFGFFTSDF-------KAKSSIQFYNKVISS 964 A +D++R+ GY A+ L ++ R G F DF K KSS +Y ++I Sbjct: 395 AIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 454 Query: 965 RGF 967 GF Sbjct: 455 NGF 457 >5W21-A nrPDB Length = 981 Score = 871 bits (2251), Expect = 0.0, Method: Compositional matrix adjust. Identities = 452/965 (46%), Positives = 621/965 (64%), Gaps = 44/965 (4%) Query: 55 GDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI 114 GDG W++ P E+ TFP F W +G+ A Q EG W++ GKG SIWD F Sbjct: 36 GDGAQTWARFSR-PPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFT 94 Query: 115 HTHL------KNVSSTNGS------------SDSYIFLEKDLSALDFIGVSFYQFSISWP 156 H L +N S G+ SDSY + +D AL +GV+ Y+FSISW Sbjct: 95 HHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWA 154 Query: 157 RLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIID 216 R+ P+G V N +GL+YY LL+ L ++P+VTLYHWDLP LQ+ YGGW N + D Sbjct: 155 RVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALAD 214 Query: 217 IFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA 276 F DYA CF+ FG +VKYWITI NPY+VAWHGY TG APG +G+ Y V HNL+ A Sbjct: 215 HFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLA 274 Query: 277 HSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHG 336 H+KVWH YNT FRP Q G +SI L SHWI P R + I +CQ+S+ VLGWFA P+ Sbjct: 275 HAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTD-HSIKECQKSLDFVLGWFAKPVFI 333 Query: 337 DGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPN-NFKPLNTMAKMGQNVSLN 395 DGDYPE M+ L S+LP F+E+EK ++GTADFFA FGP +F+ L+ K Q S N Sbjct: 334 DGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPN 393 Query: 396 LREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 LR+ L+WI LE+N+P+I I ENGWF K +D +Y +K F+ + L+AI+LD + V Sbjct: 394 LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVI 453 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF-SLKEST 514 GYTAWSL+DGFEW Y+IRRGLFYVDF S+ K PKSSA +Y+++I +NGF L E+ Sbjct: 454 GYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQ 513 Query: 515 PDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPA 574 P ++G FPCDF+WGV ++ ++ ++ S QF+D ++Y+W+ ++ L +V+GV K R + Sbjct: 514 P-LEGTFPCDFAWGVVDNYIQVDTTLS--QFTDLNVYLWDVHHSKRLIKVDGVVTKKRKS 570 Query: 575 QCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLG 634 C DF I+ Q+ +L M VTH+RF+LDWA +LP GN S VN L+YYRC+ SE +++ Sbjct: 571 YCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVN 630 Query: 635 ISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP 694 I+ +V L+ P + GLP L W NP TA AF YA LCFQELG VKLWIT+NEP Sbjct: 631 ITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEP 690 Query: 695 NRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYA 754 Y R N TY A HNLL AHALAW +Y+ +FR +Q G +S++L ADW EPA P++ Sbjct: 691 ------YTR--NMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFS 742 Query: 755 DSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLL 814 AER L+F+I W AEP+F +GDYP MR+++ + ++ LP TE E++L+ Sbjct: 743 QKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQR-----NNFLLPYFTEDEKKLI 797 Query: 815 KGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLR 874 +GT DF AL+H+TT V E+ +Y+ ++Q + DIT L+SP+++AV+PWG+RK+L Sbjct: 798 QGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLN 857 Query: 875 WVRRNYGDMDIYITASGIDDQA-LEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKL 933 W++ YGD+ +YI ++GIDD EDD+LR YY+ Y+ E LKA+++D + + GY+A+ Sbjct: 858 WLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSF 917 Query: 934 AEEKSKPRFGFF---TSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLF 990 +++ PRFG + F+ K+S++ Y K+I S GFP + R +E T CT C F Sbjct: 918 -NDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFC-PEEFTVCTECSF 975 Query: 991 LVQKK 995 +K Sbjct: 976 FHTRK 980 >3VKK-A nrPDB Length = 469 Score = 320 bits (821), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 177/466 (37%), Positives = 253/466 (54%), Gaps = 37/466 (7%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNGSSDSYIFLEK 136 FP F W T A QVEG W DGKGP +WD F H + V + + + SY E+ Sbjct: 2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEE 61 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 DL + +G++ Y+FS+SW RL PDG N KG+ YY+ ++D L+ + PIVTLYH+ Sbjct: 62 DLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHF 121 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP L+++ GGW ++ II+ F+ YA +CF FGDRVK WITI+ +++ Y GM Sbjct: 122 DLPQTLEDQ-GGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINQANVLSVMSYDLGMFP 180 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG Y HNLIKAH++ WH+Y++ FR QKG +S++L + W+EP + D Sbjct: 181 PGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQ 240 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV----------LPIFSEAEKHEMRGT 366 ++++ L FA PI DGDYPE ++ ++ S+ LP F+E EK ++GT Sbjct: 241 EAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGT 300 Query: 367 ADFFAFSFGPNNFKPL--NTMAKMG---------------QNVS------LNLREALNWI 403 ADFFA + N ++G +NV + + L +I Sbjct: 301 ADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYI 360 Query: 404 KLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL 463 K YNNP I I ENG+ +DT + ++ +AI+LD++ + Y AWSLL Sbjct: 361 KDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLL 420 Query: 464 DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 D FEW Y+ R GLF+VDF + R P +SA Y +IIR NG Sbjct: 421 DNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466 Score = 266 bits (679), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 164/474 (34%), Positives = 250/474 (52%), Gaps = 38/474 (8%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F W + + E + VW+ ++ RV + +T C + Sbjct: 3 FPAGFGWAAATAAYQVEGGWDA---DGKGPCVWDTFTHQGGERV--FKNQTGDVACGSYT 57 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ L+ + ++ +THYRF+L W+ +LP G +N++ + YY ++ + LK G++ +VT Sbjct: 58 LWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVT 117 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GWL+ + E+F YA CF GD VK WITIN+ N LS + Sbjct: 118 LY-----HFDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINQANVLSVM 172 Query: 701 -YNRS---------GNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 Y+ G Y AAHNL+ AHA +W YD FR Q+G VSLSL A W EPA Sbjct: 173 SYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPA 232 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIAS-KHRRGLSSSALPRLTEA 809 +P + S AA+R + F + FA+P+F GDYP ++ IAS ++G SS LP TE Sbjct: 233 DPNSVSDQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEE 292 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYD--SDRDIQFLQDITRLSSPTRLAVIPW 867 E++++KGT DF A+ ++TTR + +++ D +I+F D + + + V+PW Sbjct: 293 EKKMIKGTADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPS-WKNVDWIYVVPW 351 Query: 868 GVRKLLRWVRRNYGDMDIYITASGI--DDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRI 925 GV KLL++++ Y + IYIT +G D A DD R Y + QE+ KA +DKV + Sbjct: 352 GVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNL 411 Query: 926 KGYYAFKLAE-----EKSKPRFGFFTSDFKAK-------SSIQFYNKVISSRGF 967 + Y A+ L + + RFG F DF+ +S + Y K+I + G Sbjct: 412 QVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465 >1WCG-A nrPDB Length = 464 Score = 295 bits (756), Expect = 6e-80, Method: Compositional matrix adjust. Identities = 174/460 (37%), Positives = 255/460 (55%), Gaps = 42/460 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV-SSTNG--SSDSYIFLEKD 137 FPK+F +G T + Q+EG W +DGKG +IWD +HT + + TNG + DSY ++D Sbjct: 5 FPKDFMFGTSTASYQIEGGWNEDGKGENIWDRLVHTSPEVIKDGTNGDIACDSYHKYKED 64 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + + + FY+FSISW R+ P G++ KG+ YY+ L++ L+ +I P+VT+YHWD Sbjct: 65 VAIIKDLNLKFYRFSISWARIAPSGVMNSLEPKGIAYYNNLINELIKNDIIPLVTMYHWD 124 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP LQ+ GGW N + D F +YA F FGDRVK+WIT + P V GY +AP Sbjct: 125 LPQYLQD-LGGWVNPIMSDYFKEYARVLFTYFGDRVKWWITFNEPIAVC-KGYSIKAYAP 182 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 Y GH + AH K + Y F+P Q G +SI++ + P +E+ DI Sbjct: 183 NLNLKTTGHYLAGHTQLIAHGKAYRLYEEMFKPTQNGKISISISGVFFMPKNAESDDDIE 242 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGTA 367 +++ GWF +P++ GDYP M+K + +S LP F++ E ++GTA Sbjct: 243 TAERANQFERGWFGHPVY-KGDYPPIMKKWVDQKSKEEGLPWSKLPKFTKDEIKLLKGTA 301 Query: 368 DFFAF--------SFG--PN-NFKPLNTM------AKMGQN-------VSLNLREALNWI 403 DF+A +FG PN NF P + A + N V LR+ L W+ Sbjct: 302 DFYALNHYSSRLVTFGSDPNPNFNPDASYVTSVDEAWLKPNETPYIIPVPEGLRKLLIWL 361 Query: 404 KLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL 463 K EY NP++LI ENG+ D ++ +D I +KN+L+ LQA+ D+ V GYT WSLL Sbjct: 362 KNEYGNPQLLITENGYGDDGQL--DDFEKISYLKNYLNATLQAMYEDKCNVIGYTVWSLL 419 Query: 464 DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 D FEW Y+I GL +DFN Q+ R + S Y+K ++ Sbjct: 420 DNFEWFYGYSIHFGLVKIDFNDPQRTRTKRESYTYFKNVV 459 Score = 224 bits (571), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 141/444 (31%), Positives = 221/444 (49%), Gaps = 55/444 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATG------NRLLHRV-EGVRLKTR 572 +FP DF +G + + + E WN G +RL+H E ++ T Sbjct: 4 KFPKDFMFGTSTASYQIEGG-------------WNEDGKGENIWDRLVHTSPEVIKDGTN 50 Query: 573 -PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGL 631 C + K+ + ++ + + YRF++ WA + P+G ++++ + + YY +++E + Sbjct: 51 GDIACDSYHKYKEDVAIIKDLNLKFYRFSISWARIAPSGVMNSLEPKGIAYYNNLINELI 110 Query: 632 KLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITI 691 K I +VT+Y H LP+ L GW+NP ++ F+ YA + F GD VK WIT Sbjct: 111 KNDIIPLVTMY-----HWDLPQYLQDLGGWVNPIMSDYFKEYARVLFTYFGDRVKWWITF 165 Query: 692 NEPNRLSDIY---------NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSL 742 NEP + Y N Y A H L+AH A+RLY+ F+P+Q G +S+S+ Sbjct: 166 NEPIAVCKGYSIKAYAPNLNLKTTGHYLAGHTQLIAHGKAYRLYEEMFKPTQNGKISISI 225 Query: 743 HADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRR-GLSSS 801 + P N +D AER QFE WF P++K GDYP M++++ K + GL S Sbjct: 226 SGVFFMPKNAESDDDIETAERANQFERGWFGHPVYK-GDYPPIMKKWVDQKSKEEGLPWS 284 Query: 802 ALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTR 861 LP+ T+ E +LLKGT DF ALNH+++R V + SD + F D + ++S Sbjct: 285 KLPKFTKDEIKLLKGTADFYALNHYSSRLVT--------FGSDPNPNFNPDASYVTSVDE 336 Query: 862 ----------LAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYL 911 + +P G+RKLL W++ YG+ + IT +G D DD + YL YL Sbjct: 337 AWLKPNETPYIIPVPEGLRKLLIWLKNEYGNPQLLITENGYGDDGQLDDFEKISYLKNYL 396 Query: 912 QEVLKAYLIDKVRIKGYYAFKLAE 935 L+A DK + GY + L + Sbjct: 397 NATLQAMYEDKCNVIGYTVWSLLD 420 >5YJ7-A nrPDB Length = 518 Score = 290 bits (741), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 167/470 (35%), Positives = 248/470 (52%), Gaps = 41/470 (8%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF--IHTHLKNVSSTNGSSDSYIFLEKD 137 FP+ F WG T A Q+EG+ +DG+GPS+WD F I + N + + + D Y ++D Sbjct: 30 AFPEGFLWGAATAAYQIEGAAAEDGRGPSMWDTFSKIPGKIDNGDTGDVACDHYHRYKED 89 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FS+SW R+ P+G + N KG+++Y L + L+ I P VTLYHWD Sbjct: 90 VKLMKGMGLKSYRFSVSWSRVLPEGTGAI-NPKGMEFYQNLTNELIANGIVPTVTLYHWD 148 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP AL K GGW N+ F YA FQ GDRVK W T++ P+ A GYG G HAP Sbjct: 149 LPEALS-KNGGWLNEDTAVAFGQYADVMFQALGDRVKLWFTLNEPWTTAIAGYGQGGHAP 207 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G K Y GHN + H+ Y ++ Q G + L + W EP D Sbjct: 208 GLKNMAENPYMAGHNQLLGHAAAVKVYREKYQEKQGGKIGAVLSTEWKEP-LCHTQEDKD 266 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSF--- 374 ++S++ L WFA+PI+ GDYPE M++++ +P F+E +K +++G+ADFF + Sbjct: 267 AAERSLIWYLAWFADPIY-KGDYPEEMKERVGDRMPAFTEQQKQDLKGSADFFGINHYAT 325 Query: 375 ----GP-------NNFKPLNTMAKMGQN-----------VSLNLREALNWIKLEYNNPRI 412 GP N F LN M V +R L WIK Y++P + Sbjct: 326 NLLQGPTEKIGAENYFSDLNGWIMMDPRWAVGDASWLSVVPWGMRRLLRWIKHRYDDPVV 385 Query: 413 LIAENGWFT--DSRVKTE----DTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 + ENG +S + E D + ++ +++++ +AI D+++V GY WSLLD F Sbjct: 386 YVTENGLSVPNESAMTPEAALNDKMRVDYLQGYVAEMWKAINYDKVKVAGYYHWSLLDNF 445 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPD 516 EW D Y +R GL VD+ K ++R K SA YK +I + +S + PD Sbjct: 446 EWSDGYKVRFGLVQVDY--KTQKRTLKESAKVYKDMIAK--YSGDTAPPD 491 Score = 229 bits (585), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 154/494 (31%), Positives = 250/494 (50%), Gaps = 60/494 (12%) Query: 501 QIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRL 560 ++ E F+ K++ FP F WG + + E A+ P + W+ T +++ Sbjct: 17 ELTAEEVFASKDTA------FPEGFLWGAATAAYQIEGAAAE-DGRGPSM--WD-TFSKI 66 Query: 561 LHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQAL 620 +++ T C + K+ ++++ M + YRF++ W+ VLP G A+N + + Sbjct: 67 PGKID--NGDTGDVACDHYHRYKEDVKLMKGMGLKSYRFSVSWSRVLPEGT-GAINPKGM 123 Query: 621 RYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQE 680 +Y+ + +E + GI VTLY H LPE L GWLN TA AF YA + FQ Sbjct: 124 EFYQNLTNELIANGIVPTVTLY-----HWDLPEALSKNGGWLNEDTAVAFGQYADVMFQA 178 Query: 681 LGDLVKLWITINEPNRLSDI-YNRSGN---------DTYGAAHNLLVAHALAWRLYDRQF 730 LGD VKLW T+NEP + Y + G+ + Y A HN L+ HA A ++Y ++ Sbjct: 179 LGDRVKLWFTLNEPWTTAIAGYGQGGHAPGLKNMAENPYMAGHNQLLGHAAAVKVYREKY 238 Query: 731 RPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYI 790 + Q G + L +W EP + AAER L + +AWFA+P++K GDYP M+E + Sbjct: 239 QEKQGGKIGAVLSTEWKEPLC-HTQEDKDAAERSLIWYLAWFADPIYK-GDYPEEMKERV 296 Query: 791 ASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMH--EQLAGSRYDSDRDIQ 848 + +P TE +++ LKG+ DF +NH+ T + E++ Y SD + Sbjct: 297 GDR---------MPAFTEQQKQDLKGSADFFGINHYATNLLQGPTEKIGAENYFSDLNGW 347 Query: 849 FLQDIT-RLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID--------DQALED 899 + D + + L+V+PWG+R+LLRW++ Y D +Y+T +G+ +A + Sbjct: 348 IMMDPRWAVGDASWLSVVPWGMRRLLRWIKHRYDDPVVYVTENGLSVPNESAMTPEAALN 407 Query: 900 DRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFKA--- 951 D++R YL Y+ E+ KA DKV++ GYY + L + + K RFG D+K Sbjct: 408 DKMRVDYLQGYVAEMWKAINYDKVKVAGYYHWSLLDNFEWSDGYKVRFGLVQVDYKTQKR 467 Query: 952 --KSSIQFYNKVIS 963 K S + Y +I+ Sbjct: 468 TLKESAKVYKDMIA 481 >3WBE-A nrPDB Length = 489 Score = 286 bits (731), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 170/477 (35%), Positives = 255/477 (53%), Gaps = 57/477 (11%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKD 137 +FP+ F +G + A Q EG+ K+DG+G +IWD F HT + + S+ + + D Y E+D Sbjct: 17 SFPEGFVFGTASAAYQYEGAVKEDGRGQTIWDTFAHTFGKITDFSNADVAVDQYHRFEED 76 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FSI+W R++P+G+ V N G+ +Y+ L+DAL+ + I+P VTLYHWD Sbjct: 77 IQLMADMGMDAYRFSIAWSRIYPNGVGQV-NQAGIDHYNKLIDALLAKGIQPYVTLYHWD 135 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP AL++KY GW + I+D F YA CF+ FGDRVK+WIT++ P+ VA GY G+ AP Sbjct: 136 LPQALEDKYKGWLDRQIVDDFAAYAETCFREFGDRVKHWITLNQPHTVAIQGYDAGLQAP 195 Query: 258 G----------EKGNLAAV-YTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIE 306 G + GN Y V H+ I AH+ Y T ++ Q G L I W E Sbjct: 196 GRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAAAASIYRTKYKATQNGQLGIAFDVMWFE 255 Query: 307 PNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGT 366 P S T+DI +++ LGWFA+P GDYP MR ++ LP F+ E ++G Sbjct: 256 P-MSNTTIDIEAAKRAQEFQLGWFADPFFF-GDYPATMRARVGERLPRFTADEAAVVKGA 313 Query: 367 ADFFAFSFGP------NNFKPL-----NTMAKMGQNVSL--------------------- 394 DF + NN + NT+A G VSL Sbjct: 314 LDFVGINHYTTYYTRHNNTNIIGTLLNNTLADTG-TVSLPFKNGKPIGDRANSIWLYIVP 372 Query: 395 -NLREALNWIKLEYNNPRILIAENGW------FTDSRVKTEDTTAIYMMKNFLSQVLQAI 447 +R +N++K YN+P + I ENG F + +D+ I ++L+ + +I Sbjct: 373 RGMRSLMNYVKERYNSPPVYITENGMDDSNNPFISIKDALKDSKRIKYHNDYLTNLAASI 432 Query: 448 RLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504 + D V GY AWSLLD +EW Y+ R GL++VD+ K R PK+S ++K +++ Sbjct: 433 KEDGCDVRGYFAWSLLDNWEWAAGYSSRFGLYFVDYKDNLK-RYPKNSVQWFKALLK 488 Score = 186 bits (472), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 131/459 (28%), Positives = 221/459 (48%), Gaps = 92/459 (20%) Query: 574 AQCTDFVN----------IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYY 623 + TDF N ++ ++++A M + YRF++ W+ + P G + VN+ + +Y Sbjct: 55 GKITDFSNADVAVDQYHRFEEDIQLMADMGMDAYRFSIAWSRIYPNG-VGQVNQAGIDHY 113 Query: 624 RCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELG 682 ++ L GI VTLY H LP+ L GWL+ + F AYA CF+E G Sbjct: 114 NKLIDALLAKGIQPYVTLY-----HWDLPQALEDKYKGWLDRQIVDDFAAYAETCFREFG 168 Query: 683 DLVKLWITINEPNRLS------------------DIYNRSGN---DTYGAAHNLLVAHAL 721 D VK WIT+N+P+ ++ +Y ++GN + Y AH+ ++AHA Sbjct: 169 DRVKHWITLNQPHTVAIQGYDAGLQAPGRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAA 228 Query: 722 AWRLYDRQFRPSQRGAVSLSLHADWAEP-ANPYADSHWRAAERFLQFEIAWFAEPLFKTG 780 A +Y +++ +Q G + ++ W EP +N D AA+R +F++ WFA+P F G Sbjct: 229 AASIYRTKYKATQNGQLGIAFDVMWFEPMSNTTIDI--EAAKRAQEFQLGWFADPFF-FG 285 Query: 781 DYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHE--QLAG 838 DYPA MR + + LPR T E ++KG +DF +NH+TT + H + G Sbjct: 286 DYPATMRARVGER---------LPRFTADEAAVVKGALDFVGINHYTTYYTRHNNTNIIG 336 Query: 839 SRYDSDRDIQFLQDITRLSSPTR-------------LAVIPWGVRKLLRWVRRNYGDMDI 885 + ++ L D +S P + L ++P G+R L+ +V+ Y + Sbjct: 337 TLLNNT-----LADTGTVSLPFKNGKPIGDRANSIWLYIVPRGMRSLMNYVKERYNSPPV 391 Query: 886 YITASGIDD---------QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE 936 YIT +G+DD AL+D + KY+ YL + + D ++GY+A+ L + Sbjct: 392 YITENGMDDSNNPFISIKDALKDSKRIKYH-NDYLTNLAASIKEDGCDVRGYFAWSLLDN 450 Query: 937 -----KSKPRFGFFTSDFK------AKSSIQFYNKVISS 964 RFG + D+K K+S+Q++ ++ + Sbjct: 451 WEWAAGYSSRFGLYFVDYKDNLKRYPKNSVQWFKALLKT 489 >3VIK-A nrPDB Length = 487 Score = 277 bits (708), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 167/464 (35%), Positives = 245/464 (52%), Gaps = 46/464 (9%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNGSSDSYIFLEK 136 TFP F G T + Q+EG+W ++GKGP+IWD H H V ++ + + DSY ++ Sbjct: 11 TFPDEFKLGAATASYQIEGAWDENGKGPNIWDTLTHEHPDYVVDGATGDIADDSYHLYKE 70 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 D+ L +G Y+FSISW R+ P+G + N G+ YY+ L++ L+ IEP+VT+YHW Sbjct: 71 DVKILKELGAQVYRFSISWARVLPEGHDNIVNQDGIDYYNNLINELLANGIEPMVTMYHW 130 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGT--GM 254 DLP ALQ+ GGW N + +YA F+ FGDRVK W+T ++P L GY + GM Sbjct: 131 DLPQALQD-LGGWPNLVLAKYSENYARVLFKNFGDRVKLWLTFNSP-LTFMDGYASEIGM 188 Query: 255 HAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTM 314 AP Y H +I AH++++H Y+ FR Q G + I+L +W EP + + Sbjct: 189 -APSINTPGIGDYLAAHTVIHAHARIYHLYDQEFRAEQGGKVGISLNINWCEP-ATNSAE 246 Query: 315 DIFKCQQSMVSVLGWFANPIHG-DGDYPEGMRKKLF----------SVLPIFSEAEKHEM 363 D C+ LG +A+PI +GDYP ++ ++ S LP F+ E + Sbjct: 247 DRASCENYQQFNLGLYAHPIFTEEGDYPAVLKDRVSRNSADEGYTDSRLPQFTAEEVEYI 306 Query: 364 RGTADFFAFSF--------GPNNFKP---LNTMAKMGQN-------------VSLNLREA 399 RGT DF +F G ++P ++ + Q+ V R+ Sbjct: 307 RGTHDFLGINFYTALLGKSGVEGYEPSRYRDSGVILTQDAAWPISASSWLKVVPWGFRKE 366 Query: 400 LNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTA 459 LNWIK EYNNP + I ENG F+D DT ++ L ++L+AI D + V GYTA Sbjct: 367 LNWIKNEYNNPPVFITENG-FSDYG-GLNDTGRVHYYTEHLKEMLKAIHEDGVNVIGYTA 424 Query: 460 WSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 WSL+D FEW Y+ + G++ VDF + R PK SA +I+ Sbjct: 425 WSLMDNFEWLRGYSEKFGIYAVDFEDPARPRIPKESAKVLAEIM 468 Score = 218 bits (554), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 136/413 (32%), Positives = 213/413 (51%), Gaps = 34/413 (8%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 K+ +++L + YRF++ WA VLP G+ + VN+ + YY +++E L GI MVT+Y Sbjct: 69 KEDVKILKELGAQVYRFSISWARVLPEGHDNIVNQDGIDYYNNLINELLANGIEPMVTMY 128 Query: 643 YPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIY- 701 H LP+ L GW N A+ + YA + F+ GD VKLW+T N P D Y Sbjct: 129 -----HWDLPQALQDLGGWPNLVLAKYSENYARVLFKNFGDRVKLWLTFNSPLTFMDGYA 183 Query: 702 ---------NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANP 752 N G Y AAH ++ AHA + LYD++FR Q G V +SL+ +W EPA Sbjct: 184 SEIGMAPSINTPGIGDYLAAHTVIHAHARIYHLYDQEFRAEQGGKVGISLNINWCEPATN 243 Query: 753 YADSHWRAAERFLQFEIAWFAEPLF-KTGDYPAAMREYIA-SKHRRGLSSSALPRLTEAE 810 A+ + E + QF + +A P+F + GDYPA +++ ++ + G + S LP+ T E Sbjct: 244 SAEDR-ASCENYQQFNLGLYAHPIFTEEGDYPAVLKDRVSRNSADEGYTDSRLPQFTAEE 302 Query: 811 RRLLKGTVDFCALNHFTTRFVMH--EQLAGSRYDSDRDIQFLQDIT-RLSSPTRLAVIPW 867 ++GT DF +N +T E SRY D + QD +S+ + L V+PW Sbjct: 303 VEYIRGTHDFLGINFYTALLGKSGVEGYEPSRY-RDSGVILTQDAAWPISASSWLKVVPW 361 Query: 868 GVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKG 927 G RK L W++ Y + ++IT +G D +D R +Y ++L+E+LKA D V + G Sbjct: 362 GFRKELNWIKNEYNNPPVFITENGFSDYGGLNDTGRVHYYTEHLKEMLKAIHEDGVNVIG 421 Query: 928 YYAFKLAEE-----KSKPRFGFFTSDFK-------AKSSIQFYNKVISSRGFP 968 Y A+ L + +FG + DF+ K S + +++++R P Sbjct: 422 YTAWSLMDNFEWLRGYSEKFGIYAVDFEDPARPRIPKESAKVLAEIMNTRKIP 474 >2RGL-A nrPDB Length = 481 Score = 270 bits (691), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 163/470 (34%), Positives = 252/470 (53%), Gaps = 51/470 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKD 137 FPK F +G T A QVEG G+GPSIWD F HT + NG ++D Y ++D Sbjct: 19 AFPKRFVFGTVTSAYQVEGMAASGGRGPSIWDAFAHTPGNVAGNQNGDVATDQYHRYKED 78 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + + Y+FSISW R+FPDG V N +G+ YY+ L++ L+ + I P V LYH+D Sbjct: 79 VNLMKSLNFDAYRFSISWSRIFPDGEGRV-NQEGVAYYNNLINYLLQKGITPYVNLYHYD 137 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LPLAL++KYGGW N + D+F +YA +CF+ FG+RVK+W T + P +VA GY G + P Sbjct: 138 LPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNEPRIVALLGYDQGTNPP 197 Query: 258 GEKGNLAA-------VYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRS 310 AA Y V HN + +H+ Y T ++ Q+G + I L +W E S Sbjct: 198 KRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQGKVGIVLDFNWYEA-LS 256 Query: 311 ENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFF 370 +T D Q++ +GW+ +P+ +G YP+ M+ + LP F+ + ++G+AD+ Sbjct: 257 NSTEDQAAAQRARDFHIGWYLDPLI-NGHYPQIMQDLVKDRLPKFTPEQARLVKGSADYI 315 Query: 371 A-----------------------------FSFGPNNFKPLNTMAKMG--QNVSLNLREA 399 + F N KP+ A V + Sbjct: 316 GINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNG-KPIGPQANSNWLYIVPWGMYGC 374 Query: 400 LNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVLQAIRLDEIRVF 455 +N+IK +Y NP ++I ENG + + + DTT ++ +++L+Q+ +AI + V Sbjct: 375 VNYIKQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVHFYRSYLTQLKKAID-EGANVA 433 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 GY AWSLLD FEW YT + G+ YVDFN+ ER PK+SA++++ +++ Sbjct: 434 GYFAWSLLDNFEWLSGYTSKFGIVYVDFNT--LERHPKASAYWFRDMLKH 481 Score = 164 bits (416), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 124/468 (26%), Positives = 216/468 (46%), Gaps = 65/468 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD-F 579 FP F +G S + E +A+S +W+A H V TD + Sbjct: 20 FPKRFVFGTVTSAYQVEGMAASGGRGPS---IWDA----FAHTPGNVAGNQNGDVATDQY 72 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ + ++ + YRF++ W+ + P G VN++ + YY +++ L+ GI+ V Sbjct: 73 HRYKEDVNLMKSLNFDAYRFSISWSRIFPDGE-GRVNQEGVAYYNNLINYLLQKGITPYV 131 Query: 640 TLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 LY H LP L GWLN A+ F YA CF+ G+ VK W T NEP ++ Sbjct: 132 NLY-----HYDLPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNEPRIVA 186 Query: 699 DI-YNRSGN----------------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLS 741 + Y++ N + Y AHN L++HA A Y +++ +Q+G V + Sbjct: 187 LLGYDQGTNPPKRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQGKVGIV 246 Query: 742 LHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSS 801 L +W E + + AA+R F I W+ +PL G YP M++ + + Sbjct: 247 LDFNWYEALSNSTEDQ-AAAQRARDFHIGWYLDPLI-NGHYPQIMQDLVKDR-------- 296 Query: 802 ALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQL---AGSRYDSDRDIQFL-----QDI 853 LP+ T + RL+KG+ D+ +N +T ++ +QL + Y +D + ++ + I Sbjct: 297 -LPKFTPEQARLVKGSADYIGINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNGKPI 355 Query: 854 TRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID-------DQALEDDRLRKYY 906 ++ L ++PWG+ + ++++ YG+ + IT +G+D DQ L D R ++ Sbjct: 356 GPQANSNWLYIVPWGMYGCVNYIKQKYGNPTVVITENGMDQPANLSRDQYLR-DTTRVHF 414 Query: 907 LGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDF 949 YL ++ KA + + + GY+A+ L + +FG DF Sbjct: 415 YRSYLTQLKKA-IDEGANVAGYFAWSLLDNFEWLSGYTSKFGIVYVDF 461 >4GXP-A nrPDB Length = 467 Score = 268 bits (685), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 159/462 (34%), Positives = 244/462 (52%), Gaps = 43/462 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT ++KN + + + D Y ++D+ Sbjct: 13 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 72 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ +GV Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ + I P VT++HWDL Sbjct: 73 EIIEKLGVKAYRFSISWPRILPEGTGRV-NQKGLDFYNRIIDTLLEKGITPFVTIFHWDL 131 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ K GG N I D F +Y+ F+ FGDRVK WIT + P A GYG+G APG Sbjct: 132 PFALQLK-GGLLNREIADWFAEYSRVLFENFGDRVKNWITFNEPLCSAIPGYGSGTFAPG 190 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + + + +TVGHN++ AH + + + G + I L + P + + D Sbjct: 191 RQ-STSEPWTVGHNILVAHGRAVKVFRETVK---DGKIGIVLNGDFTYPWDAADPADKEA 246 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ + WFA+PI+ GDYP MRK+L LP F+ E+ + G+ DF+ + +N Sbjct: 247 AERRLEFFTAWFADPIY-LGDYPASMRKQLGDRLPTFTPEERALVHGSNDFYGMNHYTSN 305 Query: 379 F-----KPLNTMAKMG-----------------------QNVSLNLREALNWIKLEYNNP 410 + P + +G + + R+ L WI Y P Sbjct: 306 YIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETAMPWLRPCAAGFRDFLVWISKRYGYP 365 Query: 411 RILIAENGWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 I + ENG D V + D I +K ++ ++ A+ LD + V GY WSLLD F Sbjct: 366 PIYVTENGAAFDDVVSEDGRVHDQNRIDYLKAYIGAMVTAVELDGVNVKGYFVWSLLDNF 425 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 EW + Y+ R G+ YVD+++++ R K S ++Y +++ NG Sbjct: 426 EWAEGYSKRFGIVYVDYSTQK--RIVKDSGYWYSNVVKNNGL 465 Score = 191 bits (486), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 142/482 (29%), Positives = 224/482 (46%), Gaps = 62/482 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + E SP + +W+ + + G T C + Sbjct: 12 KFPEGFLWGVATASYQIEG---SPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 65 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ V YRF++ W +LP G VN++ L +Y ++ L+ GI+ V Sbjct: 66 NRWKEDIEIIEKLGVKAYRFSISWPRILPEGT-GRVNQKGLDFYNRIIDTLLEKGITPFV 124 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 T++ H LP L G LN A+ F Y+ + F+ GD VK WIT NEP L Sbjct: 125 TIF-----HWDLPFALQLKGGLLNREIADWFAEYSRVLFENFGDRVKNWITFNEP--LCS 177 Query: 700 IYNRSGNDTYG-----------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAE 748 G+ T+ HN+LVAH A +++ + G + + L+ D+ Sbjct: 178 AIPGYGSGTFAPGRQSTSEPWTVGHNILVAHGRAVKVFRETVK---DGKIGIVLNGDFTY 234 Query: 749 PANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE 808 P + + AAER L+F AWFA+P++ GDYPA+MR+ + + LP T Sbjct: 235 PWDAADPADKEAAERRLEFFTAWFADPIY-LGDYPASMRKQLGDR---------LPTFTP 284 Query: 809 AERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPW- 867 ER L+ G+ DF +NH+T+ ++ H S D+ ++ L + + +PW Sbjct: 285 EERALVHGSNDFYGMNHYTSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETAMPWL 344 Query: 868 -----GVRKLLRWVRRNYGDMDIYITASG--IDDQALEDDRL----RKYYLGKYLQEVLK 916 G R L W+ + YG IY+T +G DD ED R+ R YL Y+ ++ Sbjct: 345 RPCAAGFRDFLVWISKRYGYPPIYVTENGAAFDDVVSEDGRVHDQNRIDYLKAYIGAMVT 404 Query: 917 AYLIDKVRIKGYYA------FKLAEEKSKPRFGFFTSDFK-----AKSSIQFYNKVISSR 965 A +D V +KGY+ F+ AE SK RFG D+ K S +Y+ V+ + Sbjct: 405 AVELDGVNVKGYFVWSLLDNFEWAEGYSK-RFGIVYVDYSTQKRIVKDSGYWYSNVVKNN 463 Query: 966 GF 967 G Sbjct: 464 GL 465 >5CG0-A nrPDB Length = 489 Score = 266 bits (680), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 157/467 (33%), Positives = 238/467 (50%), Gaps = 46/467 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTH---LKNVSSTNGSSDSYIFLEKD 137 FP +F +G T + Q+EG+W +DGKG +IWD+ +H ++++S+ + ++DSY ++D Sbjct: 5 FPDDFLFGTATASYQIEGAWDEDGKGENIWDYMVHNTPEVIRDLSNGDIAADSYHNYKRD 64 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FS+SW R+ P G+ N G+ +Y+ +D ++ NI P++TLYHWD Sbjct: 65 VEMMRELGLDAYRFSLSWARILPTGMANEVNPAGIAFYNNYIDEMLKYNITPLITLYHWD 124 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP LQE GG+ N I D F DYA F+ FGDRVK +IT + P + + GYG+ AP Sbjct: 125 LPQKLQE-LGGFANPLISDWFEDYARVVFENFGDRVKMFITFNEPREICFEGYGSATKAP 183 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 Y NL+ AH+K ++ Y+ FRP Q G IT+ +W P + D Sbjct: 184 ILNATAMGAYLCAKNLVTAHAKAYYLYDREFRPVQGGQCGITISVNWFGP-ATPTPEDEM 242 Query: 318 KCQQSMVSVLGWFANPI-HGDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGT 366 + G +A+PI +G +P+ + K+ +S LP F+E EK +RGT Sbjct: 243 AAELRRQGEWGIYAHPIFSAEGGFPKELSDKIAEKSAQQGYPWSRLPEFTEEEKAFVRGT 302 Query: 367 ADFF------AFSFGPNNFKPLNTMAKMGQNVSLN-------LREALNWIKLE------- 406 +DFF AF K + + +V L+ A W+ L Sbjct: 303 SDFFGVNHYTAFLVSATERKGPYPVPSLLDDVDTGSWADDSWLKSASAWLTLAPNSIHTA 362 Query: 407 -------YNNPRILIAENGWFTDSRVKTE--DTTAIYMMKNFLSQVLQAIRLDEIRVFGY 457 YN P I ENGW TD + D I + + +L + D I + GY Sbjct: 363 LTHLNNLYNKPVFYITENGWSTDESRENSLIDDDRIQYYRASMESLLNCLD-DGINLKGY 421 Query: 458 TAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504 AWSL+D FEW + Y R GL+ VDF+ + R P+ +A YK II+ Sbjct: 422 MAWSLMDNFEWMEGYIERFGLYEVDFSDPARTRTPRKAAFVYKHIIK 468 Score = 185 bits (470), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 142/469 (30%), Positives = 216/469 (46%), Gaps = 60/469 (12%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATG------NRLLHRVEGV--RL 569 Q +FP DF +G + + E W+ G + ++H V L Sbjct: 2 QRRFPDDFLFGTATASYQIEGA-------------WDEDGKGENIWDYMVHNTPEVIRDL 48 Query: 570 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSE 629 + N K+ +EM+ + + YRF+L WA +LPTG + VN + +Y + E Sbjct: 49 SNGDIAADSYHNYKRDVEMMRELGLDAYRFSLSWARILPTGMANEVNPAGIAFYNNYIDE 108 Query: 630 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI 689 LK I+ ++TLY H LP+ L G+ NP ++ F+ YA + F+ GD VK++I Sbjct: 109 MLKYNITPLITLY-----HWDLPQKLQELGGFANPLISDWFEDYARVVFENFGDRVKMFI 163 Query: 690 TINEPNRL----------SDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 T NEP + + I N + Y A NL+ AHA A+ LYDR+FRP Q G Sbjct: 164 TFNEPREICFEGYGSATKAPILNATAMGAYLCAKNLVTAHAKAYYLYDREFRPVQGGQCG 223 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKH-RRG 797 +++ +W PA P + AAE Q E +A P+F G +P + + IA K ++G Sbjct: 224 ITISVNWFGPATPTPEDE-MAAELRRQGEWGIYAHPIFSAEGGFPKELSDKIAEKSAQQG 282 Query: 798 LSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAG-----SRYDSDRDIQFLQD 852 S LP TE E+ ++GT DF +NH+T V + G S D D D D Sbjct: 283 YPWSRLPEFTEEEKAFVRGTSDFFGVNHYTAFLVSATERKGPYPVPSLLD-DVDTGSWAD 341 Query: 853 ITRLSSPTR-LAVIPWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKY 905 + L S + L + P + L + Y YIT +G ++ ++DDR++ Y Sbjct: 342 DSWLKSASAWLTLAPNSIHTALTHLNNLYNKPVFYITENGWSTDESRENSLIDDDRIQYY 401 Query: 906 YLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDF 949 + E L L D + +KGY A+ L + E RFG + DF Sbjct: 402 ---RASMESLLNCLDDGINLKGYMAWSLMDNFEWMEGYIERFGLYEVDF 447 >1CBG-A nrPDB Length = 490 Score = 262 bits (669), Expect = 6e-70, Method: Compositional matrix adjust. Identities = 173/491 (35%), Positives = 251/491 (51%), Gaps = 61/491 (12%) Query: 66 NFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS-T 124 +F+ +N S F F +G + A Q EG+ +DGKGPSIWD F H + + + T Sbjct: 10 DFSDLNRS------CFAPGFVFGTASSAFQYEGAAFEDGKGPSIWDTFTHKYPEKIKDRT 63 Query: 125 NG--SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDA 181 NG + D Y ++D+ + + + Y+FSISWPR+ P G ++ N +G+ YY+ L++ Sbjct: 64 NGDVAIDEYHRYKEDIGIMKDMNLDAYRFSISWPRVLPKGKLSGGVNREGINYYNNLINE 123 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 ++ ++P VTL+HWD+P AL+++Y G+ I+D F DYA CF+ FGDRVK+WIT++ Sbjct: 124 VLANGMQPYVTLFHWDVPQALEDEYRGFLGRNIVDDFRDYAELCFKEFGDRVKHWITLNE 183 Query: 242 PYLVAWHGYGTGMHAPGEKGNLAAV-----------YTVGHNLIKAHSKVWHNYNTHFRP 290 P+ V+ + Y G APG + + Y H + AH+ Y T ++ Sbjct: 184 PWGVSMNAYAYGTFAPGRCSDWLKLNCTGGDSGREPYLAAHYQLLAHAAAARLYKTKYQA 243 Query: 291 HQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS 350 Q G + ITL SHW EP E D+ ++ + +LGWF +P+ G YPE MR + Sbjct: 244 SQNGIIGITLVSHWFEPASKEKA-DVDAAKRGLDFMLGWFMHPL-TKGRYPESMRYLVRK 301 Query: 351 VLPIFSEAEKHEMRGTADFFAFSFG-----------PN-----------------NFKPL 382 LP FS E E+ G+ DF ++ PN N KPL Sbjct: 302 RLPKFSTEESKELTGSFDFLGLNYYSSYYAAKAPRIPNARPAIQTDSLINATFEHNGKPL 361 Query: 383 NTMAKMGQNV--SLNLREALNWIKLEYNNPRILIAENG--WFTDSRVKTE----DTTAIY 434 MA +R+ L ++K YNNP I I ENG F D + + DT I Sbjct: 362 GPMAASSWLCIYPQGIRKLLLYVKNHYNNPVIYITENGRNEFNDPTLSLQESLLDTPRID 421 Query: 435 MMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKS 494 L VL AI D + V GY AWSL D EW YT+R GL +VDF + K R PK Sbjct: 422 YYYRHLYYVLTAIG-DGVNVKGYFAWSLFDNMEWDSGYTVRFGLVFVDFKNNLK-RHPKL 479 Query: 495 SAHYYKQIIRE 505 SAH++K +++ Sbjct: 480 SAHWFKSFLKK 490 Score = 162 bits (410), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 135/414 (32%), Positives = 209/414 (50%), Gaps = 65/414 (15%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAMVTL 641 K+ + ++ M + YRF++ W VLP G LS VNR+ + YY +++E L G+ VTL Sbjct: 76 KEDIGIMKDMNLDAYRFSISWPRVLPKGKLSGGVNREGINYYNNLINEVLANGMQPYVTL 135 Query: 642 YYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINE------- 693 + H +P+ L G+L + + F+ YA LCF+E GD VK WIT+NE Sbjct: 136 F-----HWDVPQALEDEYRGFLGRNIVDDFRDYAELCFKEFGDRVKHWITLNEPWGVSMN 190 Query: 694 --------PNRLSD------IYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 P R SD SG + Y AAH L+AHA A RLY +++ SQ G + Sbjct: 191 AYAYGTFAPGRCSDWLKLNCTGGDSGREPYLAAHYQLLAHAAAARLYKTKYQASQNGIIG 250 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 ++L + W EPA+ + AA+R L F + WF PL K G YP +MR Y+ K Sbjct: 251 ITLVSHWFEPASK-EKADVDAAKRGLDFMLGWFMHPLTK-GRYPESMR-YLVRKR----- 302 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHE-QLAGSR----YDSDRDIQFLQD-- 852 LP+ + E + L G+ DF LN++++ + ++ +R DS + F + Sbjct: 303 ---LPKFSTEESKELTGSFDFLGLNYYSSYYAAKAPRIPNARPAIQTDSLINATFEHNGK 359 Query: 853 -ITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG----------IDDQALEDDR 901 + +++ + L + P G+RKLL +V+ +Y + IYIT +G + + L+ R Sbjct: 360 PLGPMAASSWLCIYPQGIRKLLLYVKNHYNNPVIYITENGRNEFNDPTLSLQESLLDTPR 419 Query: 902 LRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDFK 950 + YY ++L VL A + D V +KGY+A+ L + RFG DFK Sbjct: 420 IDYYY--RHLYYVLTA-IGDGVNVKGYFAWSLFDNMEWDSGYTVRFGLVFVDFK 470 >3PTM-A nrPDB Length = 505 Score = 261 bits (668), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 170/477 (35%), Positives = 261/477 (54%), Gaps = 59/477 (12%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS-TNG--SSDSYIFLEK 136 +FPK F +G + + Q EG + G+GPSIWD F H H + ++ +NG +SDSY ++ Sbjct: 33 SFPKGFIFGTASSSYQYEGGAAEGGRGPSIWDTFTHQHPEKIADRSNGDVASDSYHLYKE 92 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIVTLYH 195 D+ + +G+ Y+FSISW R+ P+G + N +G++YY+ L++ L+ + ++P +TL+H Sbjct: 93 DVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNKEGIKYYNNLINELLSKGVQPFITLFH 152 Query: 196 WDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMH 255 WD P AL++KY G+ + II+ F DYA CF+ FGDRVK WIT + P+ +GY TG+ Sbjct: 153 WDSPQALEDKYNGFLSPNIINDFKDYAEICFKEFGDRVKNWITFNEPWTFCSNGYATGLF 212 Query: 256 APG-----EKGNLAA------VYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHW 304 APG EKGN + YT H+ + AH++ Y ++ QKG + ITL SHW Sbjct: 213 APGRCSPWEKGNCSVGDSGREPYTACHHQLLAHAETVRLYKAKYQALQKGKIGITLVSHW 272 Query: 305 IEP-NRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEM 363 P +RS++ D K +++ + GWF +P+ GDYP MR + + LP F++ + + Sbjct: 273 FVPFSRSKSNNDAAK--RAIDFMFGWFMDPLI-RGDYPLSMRGLVGNRLPQFTKEQSKLV 329 Query: 364 RGTADFFAFSFGPNNF-------KPLNTMAKMGQNVSLN--------------------- 395 +G DF ++ N+ LN +L Sbjct: 330 KGAFDFIGLNYYTANYADNLPPSNGLNNSYTTDSRANLTGVRNGIPIGPQAASPWLYVYP 389 Query: 396 --LREALNWIKLEYNNPRILIAENGW--FTDSRVK-----TEDTTAIYMMKNFLSQVLQA 446 R+ L ++K Y NP + I ENG F + + +D Y K+ LS +L A Sbjct: 390 QGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLPLQEALKDDARIEYYHKHLLS-LLSA 448 Query: 447 IRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 IR D V GY AWSLLD FEW + YT+R G+ +VD+N +K R PK+SAH++K+ + Sbjct: 449 IR-DGANVKGYFAWSLLDNFEWSNGYTVRFGINFVDYNDGRK-RYPKNSAHWFKKFL 503 Score = 182 bits (461), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 125/395 (31%), Positives = 206/395 (52%), Gaps = 62/395 (15%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNL-SAVNRQALRYYRCVVSEGLKLGISAMVTL 641 K+ + ++ M + YRF++ W +LP G+L VN++ ++YY +++E L G+ +TL Sbjct: 91 KEDVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNKEGIKYYNNLINELLSKGVQPFITL 150 Query: 642 YYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP-NRLSD 699 + H P+ L +G+L+P+ F+ YA +CF+E GD VK WIT NEP S+ Sbjct: 151 F-----HWDSPQALEDKYNGFLSPNIINDFKDYAEICFKEFGDRVKNWITFNEPWTFCSN 205 Query: 700 IY--------------------NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 Y SG + Y A H+ L+AHA RLY +++ Q+G + Sbjct: 206 GYATGLFAPGRCSPWEKGNCSVGDSGREPYTACHHQLLAHAETVRLYKAKYQALQKGKIG 265 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 ++L + W P + + S+ AA+R + F WF +PL + GDYP +M RGL Sbjct: 266 ITLVSHWFVPFS-RSKSNNDAAKRAIDFMFGWFMDPLIR-GDYPLSM---------RGLV 314 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSR-------YDSDRDIQFLQD 852 + LP+ T+ + +L+KG DF LN++T + + L S DS ++ +++ Sbjct: 315 GNRLPQFTKEQSKLVKGAFDFIGLNYYTANYA--DNLPPSNGLNNSYTTDSRANLTGVRN 372 Query: 853 ---ITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD---------QALEDD 900 I ++ L V P G R LL +V+ NYG+ +YIT +G+D+ +AL+DD Sbjct: 373 GIPIGPQAASPWLYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLPLQEALKDD 432 Query: 901 RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE 935 +YY K+L +L A + D +KGY+A+ L + Sbjct: 433 ARIEYY-HKHLLSLLSA-IRDGANVKGYFAWSLLD 465 >2E40-A nrPDB Length = 465 Score = 261 bits (668), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 162/460 (35%), Positives = 239/460 (51%), Gaps = 40/460 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 PK+F WG T A Q+EGS KDG+ PSIWD F + + SS + ++DSY +D+ Sbjct: 9 LPKSFVWGYATAAYQIEGSPDKDGREPSIWDTFCKAPGKIADGSSGDVATDSYNRWREDV 68 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVT-VANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 L GV Y+FS+SW R+ P G + N G+++Y TL++ LV I P VTLYHWD Sbjct: 69 QLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTLYHWD 128 Query: 198 LPLALQEKYGGWKN-DTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP AL ++YGGW N + I F +YA CF+ FGD V+ WIT + P++++ GYG G+ A Sbjct: 129 LPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISVMGYGNGIFA 188 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG N + V H++I AH+ Y F+ Q G + ITL SHW+ P + Sbjct: 189 PGHVSNTEP-WIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIP-YDDTDASK 246 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 ++M LG FANPI+ G+YP ++K L LP F+ E ++G++DFF + Sbjct: 247 EATLRAMEFKLGRFANPIY-KGEYPPRIKKILGDRLPEFTPEEIELVKGSSDFFGLNTYT 305 Query: 377 NNF----------------------KPLNTMAKMG--QNVSLNLREALNWIKLEYNNPRI 412 + L T + MG Q R LN++ Y+ P + Sbjct: 306 THLVQDGGSDELAGFVKTGHTRADGTQLGTQSDMGWLQTYGPGFRWLLNYLWKAYDKP-V 364 Query: 413 LIAENGWFTDS------RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 + ENG+ +DT +++ +LQA+ D V GY WSLLD F Sbjct: 365 YVTENGFPVKGENDLPVEQAVDDTDRQAYYRDYTEALLQAVTEDGADVRGYFGWSLLDNF 424 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 EW + Y +R G+ +VD+ +++ R PK SA + + +E+ Sbjct: 425 EWAEGYKVRFGVTHVDYETQK--RTPKKSAEFLSRWFKEH 462 Score = 162 bits (409), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 121/401 (30%), Positives = 202/401 (50%), Gaps = 52/401 (12%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAMVTL 641 ++ +++L V YRF+L W+ ++P G S VN +++YR ++ E +K GI+ VTL Sbjct: 65 REDVQLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTL 124 Query: 642 YYPTHAHLGLPEPLLHA-DGWLNPSTA-EAFQAYAGLCFQELGDLVKLWITINEP----- 694 Y H LP+ L GWLN A + F YA LCF+ GDLV+ WIT NEP Sbjct: 125 Y-----HWDLPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISV 179 Query: 695 ----NRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 N + + S + + +H++++AHA A +LY +F+ Q G + ++L + W P Sbjct: 180 MGYGNGIFAPGHVSNTEPWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIPY 239 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + D+ A R ++F++ FA P++K G+YP +++ + + LP T E Sbjct: 240 DD-TDASKEATLRAMEFKLGRFANPIYK-GEYPPRIKKILGDR---------LPEFTPEE 288 Query: 811 RRLLKGTVDFCALNHFTTRFVMH---EQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPW 867 L+KG+ DF LN +TT V ++LAG + D T+L + + + + Sbjct: 289 IELVKGSSDFFGLNTYTTHLVQDGGSDELAGFV----KTGHTRADGTQLGTQSDMGWLQT 344 Query: 868 ---GVRKLLRWVRRNYGDMDIYITASGI-----DDQALE---DDRLRKYYLGKYLQEVLK 916 G R LL ++ + Y D +Y+T +G +D +E DD R+ Y Y + +L+ Sbjct: 345 YGPGFRWLLNYLWKAY-DKPVYVTENGFPVKGENDLPVEQAVDDTDRQAYYRDYTEALLQ 403 Query: 917 AYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFKAK 952 A D ++GY+ + L + E K RFG D++ + Sbjct: 404 AVTEDGADVRGYFGWSLLDNFEWAEGYKVRFGVTHVDYETQ 444 >4JIE-A nrPDB Length = 503 Score = 261 bits (666), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 162/467 (34%), Positives = 239/467 (51%), Gaps = 49/467 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKD 137 FP+ F +G A QVEG K+ G+GPSIWD FI + N ++ + + D Y ++D Sbjct: 37 AFPEGFVFGTAASAYQVEGMAKQGGRGPSIWDAFIEKPGTIPNNATADVTVDEYHRYKED 96 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + +G Y+FSISW R+FP+G V N +G+ YY+ L+D +V + I+P LYH+D Sbjct: 97 VNIMKNMGFDAYRFSISWSRIFPNGTGMV-NQEGVDYYNRLIDYMVKKGIKPYANLYHYD 155 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LPLAL E+Y GW + I++ F DYA +CFQ FGDRVK W T + P VA GY G HAP Sbjct: 156 LPLALHEQYLGWLSPNIVEAFADYADFCFQTFGDRVKDWFTFNEPRCVAALGYDNGFHAP 215 Query: 258 GEKGNLAA-------VYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRS 310 G A Y H+LI +H+ Y ++ +QKG + I L W EP Sbjct: 216 GRCSGCDAGGNSTTEPYLAAHHLILSHAAAVKRYREKYQLYQKGRIGILLDFVWYEPFSD 275 Query: 311 ENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFF 370 N + LGWF +PI G YP M + + +P FS+ E ++ + D+ Sbjct: 276 SNADRAAAQRARDFH-LGWFLDPII-HGRYPYSMLEIVKDRMPTFSDEESRMVKDSIDYV 333 Query: 371 AFSF---------GPNNFKPLNTM-------------AKMGQN--------VSLNLREAL 400 + GP N P + +G V + +A+ Sbjct: 334 GINHYTSFYMKDPGPWNLTPTSYQDDWHVGFAYERNGVPIGAQANSYWLYIVPWGINKAV 393 Query: 401 NWIKLEYNNPRILIAENGWFTDSRVK----TEDTTAIYMMKNFLSQVLQAIRLDEIRVFG 456 ++K Y NP ++++ENG V DT I +N+++++ +AI D +V G Sbjct: 394 TYVKETYGNPTMILSENGMDQPGNVSITQGVHDTVRIRYYRNYITELKKAID-DGAKVIG 452 Query: 457 YTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 Y AWSLLD FEW+ YT R G+ YVD+ K +R PK SA ++K ++ Sbjct: 453 YFAWSLLDNFEWRLGYTSRFGIVYVDY--KTLKRYPKDSAFWFKNML 497 Score = 161 bits (407), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 122/442 (27%), Positives = 209/442 (47%), Gaps = 70/442 (15%) Query: 571 TRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEG 630 T ++ K+ + ++ M YRF++ W+ + P G VN++ + YY ++ Sbjct: 82 TADVTVDEYHRYKEDVNIMKNMGFDAYRFSISWSRIFPNGT-GMVNQEGVDYYNRLIDYM 140 Query: 631 LKLGISAMVTLYYPTHAHLGLPEPLLHAD--GWLNPSTAEAFQAYAGLCFQELGDLVKLW 688 +K GI LY H LP LH GWL+P+ EAF YA CFQ GD VK W Sbjct: 141 VKKGIKPYANLY-----HYDLPL-ALHEQYLGWLSPNIVEAFADYADFCFQTFGDRVKDW 194 Query: 689 ITINEPNRLS-----------------DIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFR 731 T NEP ++ D S + Y AAH+L+++HA A + Y +++ Sbjct: 195 FTFNEPRCVAALGYDNGFHAPGRCSGCDAGGNSTTEPYLAAHHLILSHAAAVKRYREKYQ 254 Query: 732 PSQRGAVSLSLHADWAEPANPYADSH--WRAAERFLQFEIAWFAEPLFKTGDYPAAMREY 789 Q+G + + L W E P++DS+ AA+R F + WF +P+ G YP +M E Sbjct: 255 LYQKGRIGILLDFVWYE---PFSDSNADRAAAQRARDFHLGWFLDPIIH-GRYPYSMLEI 310 Query: 790 IASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHE----QLAGSRYDSDR 845 + + +P ++ E R++K ++D+ +NH+T+ F M + L + Y D Sbjct: 311 VKDR---------MPTFSDEESRMVKDSIDYVGINHYTS-FYMKDPGPWNLTPTSYQDDW 360 Query: 846 DIQFLQD-----ITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD------ 894 + F + I ++ L ++PWG+ K + +V+ YG+ + ++ +G+D Sbjct: 361 HVGFAYERNGVPIGAQANSYWLYIVPWGINKAVTYVKETYGNPTMILSENGMDQPGNVSI 420 Query: 895 -QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSD 948 Q + D +YY Y+ E+ KA + D ++ GY+A+ L + RFG D Sbjct: 421 TQGVHDTVRIRYYR-NYITELKKA-IDDGAKVIGYFAWSLLDNFEWRLGYTSRFGIVYVD 478 Query: 949 FKA-----KSSIQFYNKVISSR 965 +K K S ++ ++SS+ Sbjct: 479 YKTLKRYPKDSAFWFKNMLSSK 500 >3WQ4-A nrPDB Length = 507 Score = 259 bits (661), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 157/473 (33%), Positives = 252/473 (53%), Gaps = 54/473 (11%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT---HLKNVSSTNGSSDSYIFLEK 136 +FP F +G + A Q EG+ K+ GKGP+IWD F H + N S+ + + D Y ++ Sbjct: 38 SFPDGFVFGAASSAYQFEGAAKEGGKGPNIWDTFTHEFPGKISNGSTGDVADDFYHRYKE 97 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIVTLYH 195 D+ L FIG+ ++ SISW R+ P G ++ N +G+ +Y+ +++ L+ + I+P +T++H Sbjct: 98 DVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQPFITIFH 157 Query: 196 WDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMH 255 WDLP AL+++YGG+ + I++ F D+A CF+ FGDRVK+WIT++ P+ ++ GY G+ Sbjct: 158 WDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPWSYSYGGYDAGLL 217 Query: 256 APGE---------KGNLAA-VYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWI 305 APG KGN Y V HNL+ +H+ Y ++ +QKG + ITL ++W+ Sbjct: 218 APGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQKGQIGITLVTYWM 277 Query: 306 EPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRG 365 P S + D Q+++ + GWF P+ G+YP+ MR+ + LP F++ + ++G Sbjct: 278 IP-YSNSKADKDAAQRALDFMYGWFIEPLS-FGEYPKSMRRLVGKRLPRFTKEQAMLVKG 335 Query: 366 TADFFAFSFGPNNFKPLNTMAKMGQNVSL------------------------------- 394 + DF ++ N+ LN N+S Sbjct: 336 SFDFLGLNYYIANYV-LNVPTSNSVNLSYTTDSLSNQTAFRNGVAIGRPTGVPAFFMYPK 394 Query: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVLQAIRLD 450 L++ L + K +YN+P I I ENG ++ V TE D +Y L + AI Sbjct: 395 GLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDPQRVYFYNQHLLSLKNAIAAG 454 Query: 451 EIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 ++V GY W+ LD FEW YT R G+ YVDF K R PK SA ++K+ + Sbjct: 455 -VKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLK-RYPKHSALWFKKFL 505 Score = 174 bits (440), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 135/476 (28%), Positives = 219/476 (46%), Gaps = 71/476 (14%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD- 578 FP F +G S + E A P+++ + H G D Sbjct: 38 SFPDGFVFGAASSAYQFEGAAKEGG-KGPNIW------DTFTHEFPGKISNGSTGDVADD 90 Query: 579 -FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGIS 636 + K+ +++L + + +R ++ WA VLP G LS VN++ + +Y V+++ L GI Sbjct: 91 FYHRYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQ 150 Query: 637 AMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINE-- 693 +T++ H LP+ L G+L+P F+ +A LCF+E GD VK WIT+NE Sbjct: 151 PFITIF-----HWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPW 205 Query: 694 -------------PNRLSDIY-----NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQR 735 P R S SG + Y HNLL++HA A +LY +++ Q+ Sbjct: 206 SYSYGGYDAGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQK 265 Query: 736 GAVSLSLHADWAEP-ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKH 794 G + ++L W P +N AD AA+R L F WF EPL G+YP +MR + + Sbjct: 266 GQIGITLVTYWMIPYSNSKADKD--AAQRALDFMYGWFIEPL-SFGEYPKSMRRLVGKR- 321 Query: 795 RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGS-----RYDSDRDIQF 849 LPR T+ + L+KG+ DF LN++ +V++ + S DS + Sbjct: 322 --------LPRFTKEQAMLVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTA 373 Query: 850 LQDITRLSSPTRLAVI---PWGVRKLLRWVRRNYGDMDIYITASGIDD-------QALED 899 ++ + PT + P G++ LL + + Y D IYIT +G+ D + ++D Sbjct: 374 FRNGVAIGRPTGVPAFFMYPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKD 433 Query: 900 DRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFK 950 + R Y+ ++L LK + V++KGY+ + + RFG DFK Sbjct: 434 PQ-RVYFYNQHLLS-LKNAIAAGVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFK 487 >3ZJ8-A nrPDB Length = 532 Score = 253 bits (647), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 157/487 (32%), Positives = 241/487 (49%), Gaps = 52/487 (10%) Query: 64 NPNFTPVNESQLFLYD-TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIH---THLK 119 N + PV S++ ++ FP++F +G G A Q EG++ + +GPSIWD F + Sbjct: 25 NSHLIPVTRSKIVVHRRDFPQDFIFGAGGSAYQCEGAYNEGNRGPSIWDTFTQRSPAKIS 84 Query: 120 NVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDG-IVTVANAKGLQYYSTL 178 + S+ N + + Y ++D+ + G+ Y+FSISW R+ P G + N G+++Y Sbjct: 85 DGSNGNQAINCYHMYKEDIKIMKQTGLESYRFSISWSRVLPGGRLAAGVNKDGVKFYHDF 144 Query: 179 LDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWIT 238 +D L+ I+P VTL+HWDLP AL+++YGG+ + I+D F +YA +CF FGD++KYW T Sbjct: 145 IDELLANGIKPSVTLFHWDLPQALEDEYGGFLSHRIVDDFCEYAEFCFWEFGDKIKYWTT 204 Query: 239 IHNPYLVAWHGYGTGMHAPGEKGN------LAAVYTVGHNLIKAHSKVWHNYNTHFRPHQ 292 + P+ A +GY G APG G Y V HN++ AH Y F+ Q Sbjct: 205 FNEPHTFAVNGYALGEFAPGRGGKGDEGDPAIEPYVVTHNILLAHKAAVEEYRNKFQKCQ 264 Query: 293 KGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVL 352 +G + I L S W+EP S+ DI ++++ +LGWF P+ GDYP+ MR+ + L Sbjct: 265 EGEIGIVLNSMWMEP-LSDVQADIDAQKRALDFMLGWFLEPL-TTGDYPKSMRELVKGRL 322 Query: 353 PIFSEAEKHEMRGTADFFAFSFG----------------------------PNNFKPLNT 384 P FS + +++G DF ++ N KP+ Sbjct: 323 PKFSADDSEKLKGCYDFIGMNYYTATYVTNAVKSNSEKLSYETDDQVTKTFERNQKPIGH 382 Query: 385 MAKMG--QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKT------EDTTAIYMM 436 G V L + L + K Y+ P + + E+G +++ K D Sbjct: 383 ALYGGWQHVVPWGLYKLLVYTKETYHVPVLYVTESGMVEENKTKILLSEARRDAERTDYH 442 Query: 437 KNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSA 496 + L+ V AI D + V GY WS D FEW Y R G+ +VD+ K ER PK SA Sbjct: 443 QKHLASVRDAID-DGVNVKGYFVWSFFDNFEWNLGYICRYGIIHVDY--KSFERYPKESA 499 Query: 497 HYYKQII 503 +YK I Sbjct: 500 IWYKNFI 506 Score = 165 bits (418), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 134/489 (27%), Positives = 217/489 (44%), Gaps = 66/489 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP DF +G S + E + +W+ R ++ + C + Sbjct: 43 FPQDFIFGAGGSAYQCEGAYNEGNRGPS---IWDTFTQRSPAKISDGSNGNQAINC--YH 97 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGISAMV 639 K+ ++++ + + YRF++ W+ VLP G L+A VN+ +++Y + E L GI V Sbjct: 98 MYKEDIKIMKQTGLESYRFSISWSRVLPGGRLAAGVNKDGVKFYHDFIDELLANGIKPSV 157 Query: 640 TLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 TL+ H LP+ L G+L+ + F YA CF E GD +K W T NEP+ + Sbjct: 158 TLF-----HWDLPQALEDEYGGFLSHRIVDDFCEYAEFCFWEFGDKIKYWTTFNEPHTFA 212 Query: 699 -DIY-------NRSGN--------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSL 742 + Y R G + Y HN+L+AH A Y +F+ Q G + + L Sbjct: 213 VNGYALGEFAPGRGGKGDEGDPAIEPYVVTHNILLAHKAAVEEYRNKFQKCQEGEIGIVL 272 Query: 743 HADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSA 802 ++ W EP + + A +R L F + WF EPL TGDYP +MRE + + Sbjct: 273 NSMWMEPLSD-VQADIDAQKRALDFMLGWFLEPL-TTGDYPKSMRELVKGR--------- 321 Query: 803 LPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGS-RYDSDRDIQFLQDITRLSSPTR 861 LP+ + + LKG DF +N++T +V + + S + + D Q + R P Sbjct: 322 LPKFSADDSEKLKGCYDFIGMNYYTATYVTNAVKSNSEKLSYETDDQVTKTFERNQKPIG 381 Query: 862 LA-------VIPWGVRKLLRWVRRNYGDMDIYITASGIDDQ--------ALEDDRLRKYY 906 A V+PWG+ KLL + + Y +Y+T SG+ ++ D R Y Sbjct: 382 HALYGGWQHVVPWGLYKLLVYTKETYHVPVLYVTESGMVEENKTKILLSEARRDAERTDY 441 Query: 907 LGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQ 956 K+L V A + D V +KGY+ + + R+G D+K+ K S Sbjct: 442 HQKHLASVRDA-IDDGVNVKGYFVWSFFDNFEWNLGYICRYGIIHVDYKSFERYPKESAI 500 Query: 957 FYNKVISSR 965 +Y I+ + Sbjct: 501 WYKNFIAGK 509 >2DGA-A nrPDB Length = 565 Score = 253 bits (647), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 159/487 (32%), Positives = 250/487 (51%), Gaps = 54/487 (11%) Query: 65 PNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS- 123 P FT + Q+ D F K+F +G T A Q+EG+W +DGKGPS WDHF HT+ + +S Sbjct: 58 PVFTKLKPWQIPKRDWFDKDFLFGASTSAYQIEGAWNEDGKGPSTWDHFCHTYPERISDM 117 Query: 124 TNG--SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 181 TNG +++SY E+D+ AL +G+ Y+FSISW R+ PDG V N G+ YY+ L+++ Sbjct: 118 TNGDVAANSYHLYEEDVKALKDMGMKVYRFSISWSRILPDGTGKV-NQAGIDYYNKLINS 176 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 L+ +I P VT++HWD P AL++KYGG+ N I+D + +A CF+ FGDRVK W T + Sbjct: 177 LIDNDIVPYVTIWHWDTPQALEDKYGGFLNRQIVDDYKQFAEVCFKNFGDRVKNWFTFNE 236 Query: 242 PYLVAWHGYGTGMHAPG-----------EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRP 290 P+ YG G+HAPG E +L YT GH+++ AH++ + + Sbjct: 237 PHTYCCFSYGEGIHAPGRCSPGMDCAVPEGDSLREPYTAGHHILLAHAEAVQLFKARYNM 296 Query: 291 HQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS 350 H + + EP + ++ +D ++S+ +GWF P+ GDYP MR + Sbjct: 297 HGDSKIGMAFDVMGYEPYQ-DSFLDDQARERSIDYNMGWFLEPVV-RGDYPFSMRSLIGD 354 Query: 351 VLPIFSEAEKHEMRGTADFFAFSF-----------GPNNFKPLN---------TMAKMGQ 390 LP+F++ E+ ++ + D ++ P+ LN T G Sbjct: 355 RLPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDMSPDFTPTLNTDDAYASSETTGSDGN 414 Query: 391 NVS------------LNLREALNWIKLEYNNPRILIAENGWF-TDSRVKTEDTTAIYMMK 437 ++ L + L +K +Y NP + I ENG + D + Sbjct: 415 DIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPVFITENGIADVEGDESMPDPLDDWKRL 474 Query: 438 NFLSQVLQAIR--LDE-IRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKS 494 ++L + + A++ +D+ V G+ W L+D FEW Y+ R GL Y+D N K RK K Sbjct: 475 DYLQRHISAVKDAIDQGADVRGHFTWGLIDNFEWSLGYSSRFGLVYIDKNDGNK-RKLKK 533 Query: 495 SAHYYKQ 501 SA ++ + Sbjct: 534 SAKWFSK 540 Score = 124 bits (312), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 107/417 (25%), Positives = 187/417 (44%), Gaps = 73/417 (17%) Query: 571 TRPAQCTDFVN----------IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQAL 620 T P + +D N ++ ++ L M + YRF++ W+ +LP G VN+ + Sbjct: 109 TYPERISDMTNGDVAANSYHLYEEDVKALKDMGMKVYRFSISWSRILPDGT-GKVNQAGI 167 Query: 621 RYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQ 679 YY +++ + I VT++ H P+ L G+LN + ++ +A +CF+ Sbjct: 168 DYYNKLINSLIDNDIVPYVTIW-----HWDTPQALEDKYGGFLNRQIVDDYKQFAEVCFK 222 Query: 680 ELGDLVKLWITINEPN---------------RLS---DIYNRSGN---DTYGAAHNLLVA 718 GD VK W T NEP+ R S D G+ + Y A H++L+A Sbjct: 223 NFGDRVKNWFTFNEPHTYCCFSYGEGIHAPGRCSPGMDCAVPEGDSLREPYTAGHHILLA 282 Query: 719 HALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHW--RAAERFLQFEIAWFAEPL 776 HA A +L+ ++ + ++ E PY DS +A ER + + + WF EP+ Sbjct: 283 HAEAVQLFKARYNMHGDSKIGMAFDVMGYE---PYQDSFLDDQARERSIDYNMGWFLEPV 339 Query: 777 FKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQL 836 + GDYP +MR I + LP T+ E+ L + D LN++T+RF H + Sbjct: 340 VR-GDYPFSMRSLIGDR---------LPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDM 389 Query: 837 A----------GSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIY 886 + + S+ DI ++ + + P G+ LL ++ YG+ ++ Sbjct: 390 SPDFTPTLNTDDAYASSETTGSDGNDIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPVF 449 Query: 887 ITASGIDDQALE-------DDRLRKYYLGKYLQEVLKAYLIDK-VRIKGYYAFKLAE 935 IT +GI D + DD R YL +++ V A ID+ ++G++ + L + Sbjct: 450 ITENGIADVEGDESMPDPLDDWKRLDYLQRHISAVKDA--IDQGADVRGHFTWGLID 504 >5JBO-A nrPDB Length = 485 Score = 253 bits (645), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 161/474 (33%), Positives = 231/474 (48%), Gaps = 51/474 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKD 137 + PK+F WG T A Q+EG+ K+ G+GPSIWD + H + NG + D Y ++D Sbjct: 7 SLPKDFEWGFATAAYQIEGAVKEGGRGPSIWDTYCHLEPSRTNGANGDVACDHYHRYDED 66 Query: 138 LSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 L G Y+FS+SW R+ P G + N +G+Q+YS L+DAL+ R + P VTLYHW Sbjct: 67 FDLLTKYGAKAYRFSLSWSRIIPLGGRLDPINEEGIQFYSNLIDALLKRGVTPWVTLYHW 126 Query: 197 DLPLALQEKYGGWKNDTIIDI-FNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMH 255 DLP AL ++YGGW N + + F YA CF+ FGDRVK WITI+ P++ + +GY TG + Sbjct: 127 DLPQALHDRYGGWLNVKEVQLDFERYARLCFERFGDRVKNWITINEPWIQSIYGYATGSN 186 Query: 256 APG---------EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIE 306 APG E + G I +H++ Y+ FR QKG + I+L + E Sbjct: 187 APGRSSINKHSTEGDTTTEPWLAGKAQIMSHARAVAVYSKDFRASQKGQIGISLNGDYYE 246 Query: 307 PNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMR-G 365 P S + D ++ M +GW+ANPI DYP MRK+L LP + A+ + G Sbjct: 247 PWDSSDPRDKEAAERRMEFHIGWYANPIFLKKDYPASMRKQLGDRLPALTPADFAILNAG 306 Query: 366 TADFFAFSFGPNNFK-----PLNTMAKMG-----------------------QNVSLNLR 397 DF+ ++ + F P+ +G ++ R Sbjct: 307 ETDFYGMNYYTSQFARHYEGPVPKTDFLGAIHEHQENKDGSPVGEESGIFWLRSCPDMFR 366 Query: 398 EALNWIKLEYNNPRILIAENGWFTDSRVK------TEDTTAIYMMKNFLSQVLQAIRLDE 451 + L + Y P I I ENG K D I + L + +AI D Sbjct: 367 KHLARVHGLYGKP-IYITENGCPCPGEDKMTCEEAINDPFRIQYFDSHLDSISKAISQDG 425 Query: 452 IRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 + V GY AW+LLD EW D Y R G+ Y D+ + + R PK SA K + + Sbjct: 426 VVVKGYFAWALLDNLEWSDGYGPRFGVTYTDYTTLK--RTPKKSALVLKDMFAD 477 Score = 170 bits (431), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 138/472 (29%), Positives = 209/472 (44%), Gaps = 65/472 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 P DF WG + + E +W+ + R G C + Sbjct: 8 LPKDFEWGFATAAYQIEGAVKEGGRGPS---IWDTYCHLEPSRTNGANGDV---ACDHYH 61 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGN-LSAVNRQALRYYRCVVSEGLKLGISAMV 639 + ++L + YRF+L W+ ++P G L +N + +++Y ++ LK G++ V Sbjct: 62 RYDEDFDLLTKYGAKAYRFSLSWSRIIPLGGRLDPINEEGIQFYSNLIDALLKRGVTPWV 121 Query: 640 TLYYPTHAHLGLPEPLLHA-DGWLNPSTAE-AFQAYAGLCFQELGDLVKLWITINEPNRL 697 TLY H LP+ L GWLN + F+ YA LCF+ GD VK WITINEP Sbjct: 122 TLY-----HWDLPQALHDRYGGWLNVKEVQLDFERYARLCFERFGDRVKNWITINEPWIQ 176 Query: 698 SDIYNRSGNDTYG-------------------AAHNLLVAHALAWRLYDRQFRPSQRGAV 738 S +G++ G A +++HA A +Y + FR SQ+G + Sbjct: 177 SIYGYATGSNAPGRSSINKHSTEGDTTTEPWLAGKAQIMSHARAVAVYSKDFRASQKGQI 236 Query: 739 SLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL 798 +SL+ D+ EP + AAER ++F I W+A P+F DYPA+MR+ + + Sbjct: 237 GISLNGDYYEPWDSSDPRDKEAAERRMEFHIGWYANPIFLKKDYPASMRKQLGDR----- 291 Query: 799 SSSALPRLTEAERRLLK-GTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLS 857 LP LT A+ +L G DF +N++T++F H + + D I Q+ + Sbjct: 292 ----LPALTPADFAILNAGETDFYGMNYYTSQFARHYEGPVPKTDFLGAIHEHQE-NKDG 346 Query: 858 SPTR-------LAVIPWGVRKLLRWVRRNYGDMDIYITASGI-----DDQALED---DRL 902 SP L P RK L V YG IYIT +G D E+ D Sbjct: 347 SPVGEESGIFWLRSCPDMFRKHLARVHGLYG-KPIYITENGCPCPGEDKMTCEEAINDPF 405 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDF 949 R Y +L + KA D V +KGY+A+ L + + PRFG +D+ Sbjct: 406 RIQYFDSHLDSISKAISQDGVVVKGYFAWALLDNLEWSDGYGPRFGVTYTDY 457 >3AIW-A nrPDB Length = 564 Score = 250 bits (639), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 159/488 (32%), Positives = 249/488 (51%), Gaps = 56/488 (11%) Query: 65 PNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS- 123 P FT + Q+ D F K+F +G T A Q+EG+W +DGKGPS WDHF HT+ + +S Sbjct: 58 PVFTKLKPWQIPKRDWFSKDFLFGASTSAYQIEGAWNEDGKGPSTWDHFCHTYPERISDG 117 Query: 124 TNG--SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 181 TNG +++SY E+D+ AL +G+ Y+FSISW R+ P+G N KG+ YY+ L+++ Sbjct: 118 TNGDVAANSYHMYEEDVKALKDMGMKVYRFSISWSRILPNG-TGKPNQKGIDYYNNLINS 176 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 L+ I P VT++HWD P AL++KYGG+ + I++ + +A CFQ FGDRVK W T + Sbjct: 177 LIRHGIVPYVTIWHWDTPQALEDKYGGFLDKQIVNDYKYFAELCFQSFGDRVKNWFTFNE 236 Query: 242 PYLVAWHGYGTGMHAPG-----------EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRP 290 P+ YG G+HAPG E +L YT GH+++ AH++ + H+ Sbjct: 237 PHTYCCFSYGEGIHAPGRCSPGLDCAVPEGDSLREPYTAGHHILLAHAEAVELFKAHYNK 296 Query: 291 HQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS 350 H + + EP + ++ +D ++S+ +GWF P+ GDYP MR + Sbjct: 297 HGDSKIGMAFDVMGYEPYQ-DSFLDDQARERSIDYNMGWFLEPVV-RGDYPFSMRSLIGD 354 Query: 351 VLPIFSEAEKHEMRGTADFFAFSFGPNNFKP-----------LNTMAKMGQNVSL----- 394 LP+F++ E+ ++ + D ++ + F LNT + + Sbjct: 355 RLPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDISSDYTPTLNTDDAYASSETTGSDGN 414 Query: 395 ----------------NLREALNWIKLEYNNPRILIAENGWFTDSRVKTE--DTTAIYMM 436 L + L +K +Y NP I I ENG D E D + Sbjct: 415 EIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPIFITENG-IADVEGDPEMPDPLDDWKR 473 Query: 437 KNFLSQVLQAIR--LDE-IRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPK 493 ++L + + A++ +D+ V G+ W L+D FEW Y+ R GL Y+D K RK K Sbjct: 474 LDYLQRHISAVKDAIDQGADVRGHFTWGLIDNFEWGSGYSSRFGLVYIDKEDGNK-RKLK 532 Query: 494 SSAHYYKQ 501 SA ++ + Sbjct: 533 KSAKWFAK 540 Score = 128 bits (321), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 106/395 (26%), Positives = 179/395 (45%), Gaps = 63/395 (15%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 ++ ++ L M + YRF++ W+ +LP G N++ + YY +++ ++ GI VT++ Sbjct: 131 EEDVKALKDMGMKVYRFSISWSRILPNGT-GKPNQKGIDYYNNLINSLIRHGIVPYVTIW 189 Query: 643 YPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN------ 695 H P+ L G+L+ ++ +A LCFQ GD VK W T NEP+ Sbjct: 190 -----HWDTPQALEDKYGGFLDKQIVNDYKYFAELCFQSFGDRVKNWFTFNEPHTYCCFS 244 Query: 696 ---------RLS---DIYNRSGN---DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL 740 R S D G+ + Y A H++L+AHA A L+ + + + Sbjct: 245 YGEGIHAPGRCSPGLDCAVPEGDSLREPYTAGHHILLAHAEAVELFKAHYNKHGDSKIGM 304 Query: 741 SLHADWAEPANPYADSHW--RAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL 798 + E PY DS +A ER + + + WF EP+ + GDYP +MR I + Sbjct: 305 AFDVMGYE---PYQDSFLDDQARERSIDYNMGWFLEPVVR-GDYPFSMRSLIGDR----- 355 Query: 799 SSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDS-DRDIQFLQDITRLS 857 LP T+ E+ L + D LN++T+RF H ++ + + D + T S Sbjct: 356 ----LPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDISSDYTPTLNTDDAYASSETTGS 411 Query: 858 SPTRLAVI---------PWGVRKLLRWVRRNYGDMDIYITASGIDDQALE-------DDR 901 + I P G+ LL ++ YG+ I+IT +GI D + DD Sbjct: 412 DGNEIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPIFITENGIADVEGDPEMPDPLDDW 471 Query: 902 LRKYYLGKYLQEVLKAYLIDK-VRIKGYYAFKLAE 935 R YL +++ V A ID+ ++G++ + L + Sbjct: 472 KRLDYLQRHISAVKDA--IDQGADVRGHFTWGLID 504 >4A3Y-A nrPDB Length = 540 Score = 249 bits (637), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 162/499 (32%), Positives = 250/499 (50%), Gaps = 79/499 (15%) Query: 71 NESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV-SSTNG--S 127 N++ FP +F G G+ A Q+EG + G+GPSIWD F H + TNG + Sbjct: 12 NDATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPSIWDTFTHRRPDMIRGGTNGDVA 71 Query: 128 SDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRN 186 DSY ++D++ L +G+ Y+FSISW R+ P G ++ N +G+ YY+ L+D L+ Sbjct: 72 VDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNLIDGLLANG 131 Query: 187 IEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVA 246 I+P VTL+HWD+P AL+++YGG+ + I+D F +YA CF FGDRVK+W+T++ P+ + Sbjct: 132 IKPFVTLFHWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWMTLNEPWTFS 191 Query: 247 WHGYGTGMHAPGEKGNLAAVY----TVGHNLIKAHSKV------------WHN------- 283 HGY TG++APG +G + + TV H + W Sbjct: 192 VHGYATGLYAPG-RGRTSPEHVNHPTVQHRCSTVAPQCICSTGNPGTEPYWVTHHLLLAH 250 Query: 284 ------YNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGD 337 Y F+ Q+G + I+ + W+EP + D+ +++ +LGWF PI Sbjct: 251 AAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGWFMEPITS- 309 Query: 338 GDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSF--------------GPNNFKPLN 383 GDYP+ M+K + S LP FS + ++G+ DF ++ G NNF N Sbjct: 310 GDYPKSMKKFVGSRLPKFSPEQSKMLKGSYDFVGLNYYTASYVTNASTNSSGSNNFS-YN 368 Query: 384 TMAKMGQNVSLN-------------------LREALNWIKLEYNNPRILIAENGW----- 419 T + N +R+ L + K YN P I + ENG Sbjct: 369 TDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIYVTENGVDDVKN 428 Query: 420 --FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRG 477 T S + +D+ + +++ + V QA+ D + V GY AWSLLD FEW + Y +R G Sbjct: 429 TNLTLSEAR-KDSMRLKYLQDHIFNVRQAMN-DGVNVKGYFAWSLLDNFEWGEGYGVRFG 486 Query: 478 LFYVDFNSKQKERKPKSSA 496 + ++D+N R PK SA Sbjct: 487 IIHIDYND-NFARYPKDSA 504 Score = 171 bits (434), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 142/496 (28%), Positives = 225/496 (45%), Gaps = 86/496 (17%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 + FP DF G S + E A +W+ +R R + +R T Sbjct: 19 RSDFPADFIMGTGSSAYQIEGGARDGGRGPS---IWDTFTHR---RPDMIRGGTNGDVAV 72 Query: 578 DFVNI-KKQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGI 635 D ++ K+ + +L + + YRF++ W+ VLP G LS VN++ + YY ++ L GI Sbjct: 73 DSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNLIDGLLANGI 132 Query: 636 SAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP 694 VTL+ H +P+ L G+L+P + F YA LCF E GD VK W+T+NEP Sbjct: 133 KPFVTLF-----HWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWMTLNEP 187 Query: 695 -------------------------------NRLSDI-------YNRSGNDTYGAAHNLL 716 +R S + G + Y H+LL Sbjct: 188 WTFSVHGYATGLYAPGRGRTSPEHVNHPTVQHRCSTVAPQCICSTGNPGTEPYWVTHHLL 247 Query: 717 VAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPL 776 +AHA A LY +F+ Q G + +S W EP + + S AA R L F + WF EP+ Sbjct: 248 LAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGWFMEPI 307 Query: 777 FKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQL 836 +GDYP +M++++ S+ LP+ + + ++LKG+ DF LN++T +V + Sbjct: 308 -TSGDYPKSMKKFVGSR---------LPKFSPEQSKMLKGSYDFVGLNYYTASYVTNAST 357 Query: 837 AGS-----RYDSDRDIQFLQD-----ITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIY 886 S Y++D + + D I S L + P G+RK+L + ++ Y IY Sbjct: 358 NSSGSNNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIY 417 Query: 887 ITASGIDD--------QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE--- 935 +T +G+DD D +R YL ++ V +A + D V +KGY+A+ L + Sbjct: 418 VTENGVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQA-MNDGVNVKGYFAWSLLDNFE 476 Query: 936 --EKSKPRFGFFTSDF 949 E RFG D+ Sbjct: 477 WGEGYGVRFGIIHIDY 492 >5OGZ-A nrPDB Length = 456 Score = 248 bits (634), Expect = 7e-66, Method: Compositional matrix adjust. Identities = 165/455 (36%), Positives = 244/455 (53%), Gaps = 37/455 (8%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKD 137 TFPK+F WG T A Q+EG++ +DGKG SIWD F HT ++ + + + + D Y E+D Sbjct: 5 TFPKDFIWGSATAAYQIEGAYNEDGKGESIWDRFSHTPGNIADGHTGDVACDHYHRYEED 64 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + IG+ Y+FSISWPR+FP+G + N KGL +Y L + L+ I P +TLYHWD Sbjct: 65 IKIMKEIGIKSYRFSISWPRIFPEGTGKL-NQKGLDFYKRLTNLLLENGIMPAITLYHWD 123 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP LQ+K GGWKN D F +Y+ F+ GD V W T + P +V+ G+ G+HAP Sbjct: 124 LPQKLQDK-GGWKNRDTTDYFTEYSEVIFKNLGDIVPIWFTHNEPGVVSLLGHFLGIHAP 182 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G K +L V HNL+ +H K + Q G +++ L H+ SE DI Sbjct: 183 GIK-DLRTSLEVSHNLLLSHGKAVKLFREMNIDAQIG-IALNLSYHY---PASEKAEDIE 237 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRK--KLFSVLPIFSEAEKHEMRGTADFFAFS-- 373 + S W+ +P+ G YPE K K + F E + + DF AF+ Sbjct: 238 AAELSFSLAGRWYLDPVL-KGRYPENALKLYKKKGIELSFPEDDLKLISQPIDFIAFNNY 296 Query: 374 ------FGPNN---FKPLNTMAKMGQNVSL-------NLREALNWIKLEYNNPRILIAEN 417 + P++ F P N++ + + + L + L + +Y P I+I+EN Sbjct: 297 SSEFIKYDPSSESGFSPANSILEKFEKTDMGWIIYPEGLYDLLMLLDRDYGKPNIVISEN 356 Query: 418 G-WFTD---SRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYT 473 G F D S K EDT I +K++L+Q +AI+ D + + Y WSLLD FEW Y Sbjct: 357 GAAFKDEIGSNGKIEDTKRIQYLKDYLTQAHRAIQ-DGVNLKAYYLWSLLDNFEWAYGYN 415 Query: 474 IRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 R G+ +V+F++ ERK K S ++YK++I+ NGF Sbjct: 416 KRFGIVHVNFDT--LERKIKDSGYWYKEVIKNNGF 448 Score = 139 bits (349), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 124/474 (26%), Positives = 215/474 (45%), Gaps = 58/474 (12%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP DF WG + + E + + +W+ + + +G T C + Sbjct: 6 FPKDFIWGSATAAYQIEGAYNEDGKGES---IWDRFSHTPGNIADG---HTGDVACDHYH 59 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ ++++ + + YRF++ W + P G +N++ L +Y+ + + L+ GI +T Sbjct: 60 RYEEDIKIMKEIGIKSYRFSISWPRIFPEGT-GKLNQKGLDFYKRLTNLLLENGIMPAIT 118 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GW N T + F Y+ + F+ LGD+V +W T NEP +S + Sbjct: 119 LY-----HWDLPQKLQDKGGWKNRDTTDYFTEYSEVIFKNLGDIVPIWFTHNEPGVVSLL 173 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRG-AVSLSLHADWAEPA 750 + G G +HNLL++H A +L+ +Q G A++LS H +E A Sbjct: 174 GHFLGIHAPGIKDLRTSLEVSHNLLLSHGKAVKLFREMNIDAQIGIALNLSYHYPASEKA 233 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPA-AMREYIASKHRRGLSSSALPRLTEA 809 AAE W+ +P+ K G YP A++ Y ++G+ S E Sbjct: 234 EDI-----EAAELSFSLAGRWYLDPVLK-GRYPENALKLY----KKKGIELS----FPED 279 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 + +L+ +DF A N++++ F+ ++ + S + I L+ + + + P G+ Sbjct: 280 DLKLISQPIDFIAFNNYSSEFIKYDPSSESGFSPANSI--LEKFEK--TDMGWIIYPEGL 335 Query: 870 RKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKV 923 LL + R+YG +I I+ +G I +D R YL YL + +A + D V Sbjct: 336 YDLLMLLDRDYGKPNIVISENGAAFKDEIGSNGKIEDTKRIQYLKDYLTQAHRA-IQDGV 394 Query: 924 RIKGYYAFKLAEE-----KSKPRFG-----FFTSDFKAKSSIQFYNKVISSRGF 967 +K YY + L + RFG F T + K K S +Y +VI + GF Sbjct: 395 NLKAYYLWSLLDNFEWAYGYNKRFGIVHVNFDTLERKIKDSGYWYKEVIKNNGF 448 >1V02-A nrPDB Length = 565 Score = 248 bits (632), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 167/476 (35%), Positives = 238/476 (50%), Gaps = 58/476 (12%) Query: 79 DTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK-NVSSTNG--SSDSYIFLE 135 D FP +F +G T A Q+EG+W +DGKGPS WDHF H + V +NG ++DSY Sbjct: 74 DWFPPSFLFGAATSAYQIEGAWNEDGKGPSTWDHFCHNFPEWIVDRSNGDVAADSYHMYA 133 Query: 136 KDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIVTLY 194 +D+ L +G+ Y+FSISWPR+ P G + N K ++YY+ L+D L+ IEP +T++ Sbjct: 134 EDVRLLKEMGMDAYRFSISWPRILPKGTLAGGINEKRVEYYNKLIDLLLENGIEPYITIF 193 Query: 195 HWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGM 254 HWD P AL + YGG+ ++ II + D+A CF+ FG VK W+T + P YGTG+ Sbjct: 194 HWDTPQALVDAYGGFLDERIIKDYTDFAKVCFEKFGKTVKNWLTFNEPETFCSVSYGTGV 253 Query: 255 HAPGE----------KGN-LAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSH 303 APG GN L+ Y V HNL++AH++ YN + + G + + L Sbjct: 254 LAPGRCSPGVSCAVPTGNSLSEPYIVAHNLLRAHAETVDIYNKYHK-GADGRIGLALNVF 312 Query: 304 WIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEM 363 P + +D ++SM LGWF P+ GDYP MR +P F E E+ ++ Sbjct: 313 GRVP-YTNTFLDQQAQERSMDKCLGWFLEPVV-RGDYPFSMRVSARDRVPYFKEKEQEKL 370 Query: 364 RGTADFFAFSF-----------GPNNFKPLNT----------------MAKMGQNVSLN- 395 G+ D ++ PNN LNT + N +N Sbjct: 371 VGSYDMIGINYYTSTFSKHIDLSPNNSPVLNTDDAYASQETKGPDGNAIGPPTGNAWINM 430 Query: 396 ----LREALNWIKLEYNNPRILIAENGWFTDSR------VKTEDTTAIYMMKNFLSQVLQ 445 L + L +K +Y NP + I ENG + V ED T + ++ LS + Q Sbjct: 431 YPKGLHDILMTMKNKYGNPPMYITENGMGDIDKGDLPKPVALEDHTRLDYIQRHLSVLKQ 490 Query: 446 AIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQ 501 +I L V GY AWSLLD FEW YT R G+ YVD ER K SA + ++ Sbjct: 491 SIDLG-ADVRGYFAWSLLDNFEWSSGYTERFGIVYVD-RENGCERTMKRSARWLQE 544 Score = 127 bits (319), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 106/395 (26%), Positives = 186/395 (47%), Gaps = 63/395 (15%) Query: 584 KQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGISAMVTLY 642 + + +L M + YRF++ W +LP G L+ +N + + YY ++ L+ GI +T++ Sbjct: 134 EDVRLLKEMGMDAYRFSISWPRILPKGTLAGGINEKRVEYYNKLIDLLLENGIEPYITIF 193 Query: 643 YPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIY 701 H P+ L+ A G+L+ + + +A +CF++ G VK W+T NEP + Sbjct: 194 -----HWDTPQALVDAYGGFLDERIIKDYTDFAKVCFEKFGKTVKNWLTFNEPETFCSVS 248 Query: 702 NRSG---------------------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL 740 +G ++ Y AHNLL AHA +Y++ + G + L Sbjct: 249 YGTGVLAPGRCSPGVSCAVPTGNSLSEPYIVAHNLLRAHAETVDIYNK-YHKGADGRIGL 307 Query: 741 SLHADWAEP-ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 +L+ P N + D +A ER + + WF EP+ + GDYP +MR ++++ R Sbjct: 308 ALNVFGRVPYTNTFLDQ--QAQERSMDKCLGWFLEPVVR-GDYPFSMR--VSARDR---- 358 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDS-DRDIQFLQDITR--- 855 +P E E+ L G+ D +N++T+ F H L+ + + D + T+ Sbjct: 359 ---VPYFKEKEQEKLVGSYDMIGINYYTSTFSKHIDLSPNNSPVLNTDDAYASQETKGPD 415 Query: 856 ---LSSPTRLAVI---PWGVRKLLRWVRRNYGDMDIYITASGIDD---------QALEDD 900 + PT A I P G+ +L ++ YG+ +YIT +G+ D ALE D Sbjct: 416 GNAIGPPTGNAWINMYPKGLHDILMTMKNKYGNPPMYITENGMGDIDKGDLPKPVALE-D 474 Query: 901 RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE 935 R Y+ ++L VLK + ++GY+A+ L + Sbjct: 475 HTRLDYIQRHLS-VLKQSIDLGADVRGYFAWSLLD 508 >4MDP-A nrPDB Length = 499 Score = 247 bits (631), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 157/470 (33%), Positives = 229/470 (48%), Gaps = 50/470 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF--IHTHLKNVSSTNGSSDSYIFLEKD 137 + P +F WG T A Q+EGS +DG+GPSIWD F I + + SS + DSY ++D Sbjct: 25 SLPPDFKWGFATAAYQIEGSVNEDGRGPSIWDTFCAIPGKIADGSSGAVACDSYKRTKED 84 Query: 138 LSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 ++ L +G + Y+FSISW R+ P G N KG+ +Y +D L+ I P +TL+HW Sbjct: 85 IALLKELGANSYRFSISWSRIIPLGGRNDPINQKGIDHYVKFVDDLIEAGITPFITLFHW 144 Query: 197 DLPLALQEKYGGWKN-DTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMH 255 DLP AL ++YGG+ N + F +YA F+ + K+WIT + P+ A GY TG Sbjct: 145 DLPDALDKRYGGFLNKEEFAADFENYARIMFKAI-PKCKHWITFNEPWCSAILGYNTGYF 203 Query: 256 APGEKGNLAAV---------YTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIE 306 APG + + + VGHN++ AH++ Y F+P Q G + ITL Sbjct: 204 APGHTSDRSKSPVGDSAREPWIVGHNILIAHARAVKAYREDFKPTQGGEIGITLNGDATL 263 Query: 307 PNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGT 366 P E+ DI C + + + WFA+PI+ G YP+ MRK+L LP F+ E ++G+ Sbjct: 264 PWDPEDPADIEACDRKIEFAISWFADPIYF-GKYPDSMRKQLGDRLPEFTPEEVALVKGS 322 Query: 367 ADFFAFSFGPNNFKPLNTMAKMGQNVSLNL----------------------------RE 398 DF+ + N+ T + NL R+ Sbjct: 323 NDFYGMNHYTANYIKHKTGVPPEDDFLGNLETLFYNKYGDCIGPETQSFWLRPHAQGFRD 382 Query: 399 ALNWIKLEYNNPRILIAENGWFTDSRVKT------EDTTAIYMMKNFLSQVLQAIRLDEI 452 LNW+ Y P+I + ENG ED + +++ + A+ D Sbjct: 383 LLNWLSKRYGYPKIYVTENGTSLKGENDMPLEQVLEDDFRVKYFNDYVRAMAAAVAEDGC 442 Query: 453 RVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI 502 V GY AWSLLD FEW + Y R G+ YVD+ + QK R PK SA K + Sbjct: 443 NVRGYLAWSLLDNFEWAEGYETRFGVTYVDYANDQK-RYPKKSAKSLKPL 491 Score = 158 bits (399), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 121/472 (25%), Positives = 203/472 (43%), Gaps = 65/472 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 P DF WG + + E + + A ++ G C + Sbjct: 25 SLPPDFKWGFATAAYQIEGSVNEDGRGPSIWDTFCAIPGKIADGSSGA------VACDSY 78 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAM 638 K+ + +L + YRF++ W+ ++P G + +N++ + +Y V + ++ GI+ Sbjct: 79 KRTKEDIALLKELGANSYRFSISWSRIIPLGGRNDPINQKGIDHYVKFVDDLIEAGITPF 138 Query: 639 VTLYYPTHAHLGLPEPL-LHADGWLNPST-AEAFQAYAGLCFQELGDLVKLWITINEP-- 694 +TL+ H LP+ L G+LN A F+ YA + F+ + K WIT NEP Sbjct: 139 ITLF-----HWDLPDALDKRYGGFLNKEEFAADFENYARIMFKAIPK-CKHWITFNEPWC 192 Query: 695 -----------------NRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGA 737 +R S + + HN+L+AHA A + Y F+P+Q G Sbjct: 193 SAILGYNTGYFAPGHTSDRSKSPVGDSAREPWIVGHNILIAHARAVKAYREDFKPTQGGE 252 Query: 738 VSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRG 797 + ++L+ D P +P + A +R ++F I+WFA+P++ G YP +MR+ + + Sbjct: 253 IGITLNGDATLPWDPEDPADIEACDRKIEFAISWFADPIY-FGKYPDSMRKQLGDR---- 307 Query: 798 LSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYD--SDRDIQFLQDITR 855 LP T E L+KG+ DF +NH+T ++ H+ D + + F Sbjct: 308 -----LPEFTPEEVALVKGSNDFYGMNHYTANYIKHKTGVPPEDDFLGNLETLFYNKYGD 362 Query: 856 LSSPTR----LAVIPWGVRKLLRWVRRNYGDMDIYITASGID---------DQALEDDRL 902 P L G R LL W+ + YG IY+T +G +Q LEDD Sbjct: 363 CIGPETQSFWLRPHAQGFRDLLNWLSKRYGYPKIYVTENGTSLKGENDMPLEQVLEDD-F 421 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDF 949 R Y Y++ + A D ++GY A+ L + E + RFG D+ Sbjct: 422 RVKYFNDYVRAMAAAVAEDGCNVRGYLAWSLLDNFEWAEGYETRFGVTYVDY 473 >3AHY-A nrPDB Length = 473 Score = 246 bits (629), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 155/464 (33%), Positives = 228/464 (49%), Gaps = 43/464 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 PK+F WG T A Q+EG+ +DG+GPSIWD F K ++G + DSY +D+ Sbjct: 9 LPKDFQWGFATAAYQIEGAVDQDGRGPSIWDTFCAQPGKIADGSSGVTACDSYNRTAEDI 68 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + L +G Y+FSISW R+ P+G A N G+ +Y +D L+ I P +TL+HWD Sbjct: 69 ALLKSLGAKSYRFSISWSRIIPEGGRGDAVNQAGIDHYVKFVDDLLDAGITPFITLFHWD 128 Query: 198 LPLALQEKYGGWKNDTIIDI-FNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP L ++YGG N T + F +YA F+ +V+ WIT + P A GYG+G A Sbjct: 129 LPEGLHQRYGGLLNRTEFPLDFENYARVMFRAL-PKVRNWITFNEPLCSAIPGYGSGTFA 187 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQ-KGWLSITLGSHWIEPNRSENTMD 315 PG + + + +TVGHN++ AH + Y F+P G + I L + P + + D Sbjct: 188 PGRQ-STSEPWTVGHNILVAHGRAVKAYRDDFKPASGDGQIGIVLNGDFTYPWDAADPAD 246 Query: 316 IFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 ++ + WFA+PI+ GDYP MRK+L LP F+ E+ + G+ DF+ + Sbjct: 247 KEAAERRLEFFTAWFADPIYL-GDYPASMRKQLGDRLPTFTPEERALVHGSNDFYGMNHY 305 Query: 376 PNNF-----------------------KPLNTMAKMGQN-----VSLNLREALNWIKLEY 407 +N+ K N + Q+ + R+ L WI Y Sbjct: 306 TSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETQSPWLRPCAAGFRDFLVWISKRY 365 Query: 408 NNPRILIAENGWFTDSRVK------TEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWS 461 P I + ENG ED + ++ ++ A+ LD + V GY AWS Sbjct: 366 GYPPIYVTENGTSIKGESDLPKEKILEDDFRVKYYNEYIRAMVTAVELDGVNVKGYFAWS 425 Query: 462 LLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 L+D FEW D Y R G+ YVD+ + QK R PK SA K + E Sbjct: 426 LMDNFEWADGYVTRFGVTYVDYENGQK-RFPKKSAKSLKPLFDE 468 Score = 166 bits (421), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 129/447 (28%), Positives = 201/447 (44%), Gaps = 59/447 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 P DF WG + + E + A ++ GV C + Sbjct: 9 LPKDFQWGFATAAYQIEGAVDQDGRGPSIWDTFCAQPGKIADGSSGV------TACDSYN 62 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAMV 639 + + +L + YRF++ W+ ++P G AVN+ + +Y V + L GI+ + Sbjct: 63 RTAEDIALLKSLGAKSYRFSISWSRIIPEGGRGDAVNQAGIDHYVKFVDDLLDAGITPFI 122 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEA--FQAYAGLCFQELGDLVKLWITINEPNRL 697 TL+ H LPE L G L T F+ YA + F+ L V+ WIT NEP L Sbjct: 123 TLF-----HWDLPEGLHQRYGGLLNRTEFPLDFENYARVMFRALPK-VRNWITFNEP--L 174 Query: 698 SDIYNRSGNDTYG-----------AAHNLLVAHALAWRLYDRQFRP-SQRGAVSLSLHAD 745 G+ T+ HN+LVAH A + Y F+P S G + + L+ D Sbjct: 175 CSAIPGYGSGTFAPGRQSTSEPWTVGHNILVAHGRAVKAYRDDFKPASGDGQIGIVLNGD 234 Query: 746 WAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPR 805 + P + + AAER L+F AWFA+P++ GDYPA+MR+ + + LP Sbjct: 235 FTYPWDAADPADKEAAERRLEFFTAWFADPIY-LGDYPASMRKQLGDR---------LPT 284 Query: 806 LTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDS--DRDIQFLQDITRLSSPTRLA 863 T ER L+ G+ DF +NH+T+ ++ H S D+ + D+ F P + Sbjct: 285 FTPEERALVHGSNDFYGMNHYTSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETQS 344 Query: 864 VIPW------GVRKLLRWVRRNYGDMDIYITASGID---------DQALEDDRLRKYYLG 908 PW G R L W+ + YG IY+T +G ++ LEDD KYY Sbjct: 345 --PWLRPCAAGFRDFLVWISKRYGYPPIYVTENGTSIKGESDLPKEKILEDDFRVKYY-N 401 Query: 909 KYLQEVLKAYLIDKVRIKGYYAFKLAE 935 +Y++ ++ A +D V +KGY+A+ L + Sbjct: 402 EYIRAMVTAVELDGVNVKGYFAWSLMD 428 >5IDI-A nrPDB Length = 452 Score = 246 bits (627), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 160/451 (35%), Positives = 246/451 (54%), Gaps = 33/451 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT ++KN + + + D Y ++D+ Sbjct: 4 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 63 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ IG Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ +NI P +T+YHWDL Sbjct: 64 EIIEKIGAKAYRFSISWPRILPEGTGKV-NQKGLDFYNRIIDTLLEKNITPFITIYHWDL 122 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P +LQ K GGW N I D F +Y+ F+ FGDRVK+WIT++ ++VA G+ G+HAPG Sbjct: 123 PFSLQLK-GGWANRDIADWFAEYSRVLFENFGDRVKHWITLNELWVVAIVGHLYGVHAPG 181 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K A +TV HNL++AH+K + + G + I + + EP SE DI Sbjct: 182 MKDIYVAFHTV-HNLLRAHAK---SVKVFRETVKDGKIGIVFNNGYFEP-ASEREEDIRA 236 Query: 319 CQ-QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFS---- 373 + + F NPI+ G+YP+ + + LP E + E++ DF + Sbjct: 237 ARFMHQFNNYPLFLNPIY-RGEYPDLVLEFAREYLPRNYEDDMEEIKQEIDFVGLNYYSG 295 Query: 374 ----FGPNNFKPLNTMAKMGQNVSLN---LREALNWI----KLEYNNPRILIAENGWFTD 422 + PN+ ++ + + ++ + E + WI K EYN + I NG D Sbjct: 296 HMVKYDPNSPARVSFVERNLPKTAMGWEIVPEGIYWILKGVKEEYNPQEVYITGNGAAFD 355 Query: 423 SRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 V K D I ++ + QV +AI+ D + + GY WSLLD FEW + Y+ R G+ Sbjct: 356 DVVSEGGKVHDQNRIDYLRAHIEQVWRAIQ-DGVPLKGYFVWSLLDNFEWAEGYSKRFGI 414 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 YVD+N+++ R K S ++Y +I+ NG + Sbjct: 415 VYVDYNTQK--RIIKDSGYWYSNVIKNNGLT 443 Score = 140 bits (353), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 127/477 (26%), Positives = 217/477 (45%), Gaps = 66/477 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + + SP + +W+ + + G T C + Sbjct: 3 KFPEGFLWGVATASYQ---IEGSPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 56 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ YRF++ W +LP G VN++ L +Y ++ L+ I+ + Sbjct: 57 NRWKEDIEIIEKIGAKAYRFSISWPRILPEGT-GKVNQKGLDFYNRIIDTLLEKNITPFI 115 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINE------ 693 T+Y H LP L GW N A+ F Y+ + F+ GD VK WIT+NE Sbjct: 116 TIY-----HWDLPFSLQLKGGWANRDIADWFAEYSRVLFENFGDRVKHWITLNELWVVAI 170 Query: 694 PNRLSDIYNRSGNDTYGA---AHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 L ++ D Y A HNLL AHA + +++ + G + + + + EPA Sbjct: 171 VGHLYGVHAPGMKDIYVAFHTVHNLLRAHAKSVKVFRETVKD---GKIGIVFNNGYFEPA 227 Query: 751 NPYADSHWRAAERFLQF-EIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + + RAA QF F P+++ G+YP + E+ + LPR E Sbjct: 228 SE-REEDIRAARFMHQFNNYPLFLNPIYR-GEYPDLVLEF---------AREYLPRNYED 276 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLA--VIPW 867 + +K +DF LN+++ V ++ + +R + F++ R T + ++P Sbjct: 277 DMEEIKQEIDFVGLNYYSGHMVKYDPNSPAR------VSFVE---RNLPKTAMGWEIVPE 327 Query: 868 GVRKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLID 921 G+ +L+ V+ Y ++YIT +G DD E D+ R YL ++++V +A + D Sbjct: 328 GIYWILKGVKEEYNPQEVYITGNGAAFDDVVSEGGKVHDQNRIDYLRAHIEQVWRA-IQD 386 Query: 922 KVRIKGYYA------FKLAEEKSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGF 967 V +KGY+ F+ AE SK RFG D+ K S +Y+ VI + G Sbjct: 387 GVPLKGYFVWSLLDNFEWAEGYSK-RFGIVYVDYNTQKRIIKDSGYWYSNVIKNNGL 442 >5BWF-A nrPDB Length = 485 Score = 244 bits (624), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 157/463 (33%), Positives = 224/463 (48%), Gaps = 42/463 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 PK+F WG T A Q+EG+ KDG+GPSIWD F K T+G + DSY +D+ Sbjct: 22 LPKDFQWGFATAAYQIEGAIDKDGRGPSIWDTFCAIPGKIADGTSGVTACDSYNRTAEDI 81 Query: 139 SALDFIGVSFYQFSISWPRLFPD-GIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + L +G Y+FSISW R+ P G N G+ +Y+ +D L+ I P +TL+HWD Sbjct: 82 ALLKSLGAKSYRFSISWSRIIPKGGRDDPVNQLGIDHYAQFVDDLLEAGITPFITLFHWD 141 Query: 198 LPLALQEKYGGWKNDTIIDI-FNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP L ++YGG N T + F +YA F+ +V+ WIT + P A GYG+G A Sbjct: 142 LPEELHQRYGGLLNRTEFPLDFENYARVMFKAL-PKVRNWITFNEPLCSAIPGYGSGTFA 200 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG + + + VGHNL+ AH + Y F+ G + I L + P S + +D Sbjct: 201 PGRQ-STTEPWIVGHNLLVAHGRAVKVYRDEFKDLNDGQIGIVLNGDFTYPWDSSDPLDR 259 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 ++ + W+A+PI+ GDYP MRK+L LP F+ EK + G+ DF+ + Sbjct: 260 EAAERRLEFFTAWYADPIYL-GDYPASMRKQLGDRLPEFTPEEKAFVLGSNDFYGMNHYT 318 Query: 377 NNFKPLNTMA----------------KMGQNVS------------LNLREALNWIKLEYN 408 +N+ T K GQ + R+ L WI YN Sbjct: 319 SNYIRHRTSPATADDTVGNVDVLFYNKEGQCIGPETESSWLRPCPAGFRDFLVWISKRYN 378 Query: 409 NPRILIAENGWFTDSRVK------TEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSL 462 P+I + ENG ED + ++ + A LD + V GY AWSL Sbjct: 379 YPKIYVTENGTSLKGENDLPKEKILEDDFRVNYYNEYIRAMFTAATLDGVNVKGYFAWSL 438 Query: 463 LDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 +D FEW D Y R G+ YVD+ + Q +R PK SA K + E Sbjct: 439 MDNFEWADGYVTRFGVTYVDYENGQ-QRFPKKSAKSLKPLFDE 480 Score = 160 bits (406), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 121/444 (27%), Positives = 197/444 (44%), Gaps = 54/444 (12%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 P DF WG + + E + A ++ GV C + Sbjct: 22 LPKDFQWGFATAAYQIEGAIDKDGRGPSIWDTFCAIPGKIADGTSGV------TACDSYN 75 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAMV 639 + + +L + YRF++ W+ ++P G VN+ + +Y V + L+ GI+ + Sbjct: 76 RTAEDIALLKSLGAKSYRFSISWSRIIPKGGRDDPVNQLGIDHYAQFVDDLLEAGITPFI 135 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEA--FQAYAGLCFQELGDLVKLWITINEPNRL 697 TL+ H LPE L G L T F+ YA + F+ L V+ WIT NEP L Sbjct: 136 TLF-----HWDLPEELHQRYGGLLNRTEFPLDFENYARVMFKALPK-VRNWITFNEP--L 187 Query: 698 SDIYNRSGNDTYG-----------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADW 746 G+ T+ HNLLVAH A ++Y +F+ G + + L+ D+ Sbjct: 188 CSAIPGYGSGTFAPGRQSTTEPWIVGHNLLVAHGRAVKVYRDEFKDLNDGQIGIVLNGDF 247 Query: 747 AEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRL 806 P + AAER L+F AW+A+P++ GDYPA+MR+ + + LP Sbjct: 248 TYPWDSSDPLDREAAERRLEFFTAWYADPIY-LGDYPASMRKQLGDR---------LPEF 297 Query: 807 TEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL------QDITRLSSPT 860 T E+ + G+ DF +NH+T+ ++ H + D+ ++ L Q I + + Sbjct: 298 TPEEKAFVLGSNDFYGMNHYTSNYIRHRTSPATADDTVGNVDVLFYNKEGQCIGPETESS 357 Query: 861 RLAVIPWGVRKLLRWVRRNYGDMDIYITASGID---------DQALEDDRLRKYYLGKYL 911 L P G R L W+ + Y IY+T +G ++ LEDD R Y +Y+ Sbjct: 358 WLRPCPAGFRDFLVWISKRYNYPKIYVTENGTSLKGENDLPKEKILEDD-FRVNYYNEYI 416 Query: 912 QEVLKAYLIDKVRIKGYYAFKLAE 935 + + A +D V +KGY+A+ L + Sbjct: 417 RAMFTAATLDGVNVKGYFAWSLMD 440 >2CBU-A nrPDB Length = 468 Score = 244 bits (623), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 158/451 (35%), Positives = 243/451 (53%), Gaps = 33/451 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT ++KN + + + D Y ++D+ Sbjct: 28 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 87 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ +GV Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ + I P VT+YHWDL Sbjct: 88 EIIEKLGVKAYRFSISWPRILPEGTGRV-NQKGLDFYNRIIDTLLEKGITPFVTIYHWDL 146 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ K GGW N I D F +Y+ F+ FGDRVK WIT++ P++VA G+ G+HAPG Sbjct: 147 PFALQLK-GGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPG 205 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + A V HNL++AH++ + + G + I + + EP SE DI Sbjct: 206 MRDIYVAFRAV-HNLLRAHARAVKVFRETVK---DGKIGIVFNNGYFEP-ASEKEEDIRA 260 Query: 319 CQ-QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFS---- 373 + + F NPI+ GDYPE + + LP + + E++ DF + Sbjct: 261 VRFMHQFNNYPLFLNPIY-RGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSG 319 Query: 374 ----FGPNNFKPLNTMAKMGQNVSLN---LREALNWI----KLEYNNPRILIAENGWFTD 422 F P+ ++ + + ++ + E + WI K EYN P + I ENG D Sbjct: 320 HLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFD 379 Query: 423 SRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 V + D I +K + Q +AI+ + + + GY WSLLD FEW + Y+ R G+ Sbjct: 380 DVVSEDGRVHDQNRIDYLKAHIGQAWKAIQ-EGVPLKGYFVWSLLDNFEWAEGYSKRFGI 438 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 YVD+++++ R K S ++Y +++ NG Sbjct: 439 VYVDYSTQK--RIVKDSGYWYSNVVKNNGLE 467 Score = 142 bits (359), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 127/476 (26%), Positives = 216/476 (45%), Gaps = 64/476 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + + SP + +W+ + + G T C + Sbjct: 27 KFPEGFLWGVATASYQ---IEGSPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 80 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ V YRF++ W +LP G VN++ L +Y ++ L+ GI+ V Sbjct: 81 NRWKEDIEIIEKLGVKAYRFSISWPRILPEGT-GRVNQKGLDFYNRIIDTLLEKGITPFV 139 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP----- 694 T+Y H LP L GW N A+ F Y+ + F+ GD VK WIT+NEP Sbjct: 140 TIY-----HWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAI 194 Query: 695 -NRLSDIYNRSGNDTY---GAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 L ++ D Y A HNLL AHA A +++ + G + + + + EPA Sbjct: 195 VGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVK---DGKIGIVFNNGYFEPA 251 Query: 751 NPYADSHWRAAERFLQF-EIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + + RA QF F P+++ GDYP + E+ + LP + Sbjct: 252 SE-KEEDIRAVRFMHQFNNYPLFLNPIYR-GDYPELVLEF---------AREYLPENYKD 300 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQ-DITRLSSPTRLAVIPWG 868 + ++ +DF LN+++ V + D+ + F++ D+ + + ++P G Sbjct: 301 DMSEIQEKIDFVGLNYYSGHLVKFDP------DAPAKVSFVERDLPK--TAMGWEIVPEG 352 Query: 869 VRKLLRWVRRNYGDMDIYITASG--IDDQALEDDRL----RKYYLGKYLQEVLKAYLIDK 922 + +L+ V+ Y ++YIT +G DD ED R+ R YL ++ + KA + + Sbjct: 353 IYWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKA-IQEG 411 Query: 923 VRIKGYYA------FKLAEEKSKPRFGFFTSDFK-----AKSSIQFYNKVISSRGF 967 V +KGY+ F+ AE SK RFG D+ K S +Y+ V+ + G Sbjct: 412 VPLKGYFVWSLLDNFEWAEGYSK-RFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGL 466 >3AHX-A nrPDB Length = 453 Score = 233 bits (595), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 158/448 (35%), Positives = 230/448 (51%), Gaps = 36/448 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FPK+F +G T A Q+EG++K+D KG SIWD F H NG + D Y ++D+ Sbjct: 6 FPKDFIFGTATAAYQIEGAYKEDEKGESIWDRFSHIPGNVAKMHNGDIACDHYHRYKEDV 65 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +G+ Y+FSI+WPR+FP G + N KG+Q+Y L+D L+ +IEP +T+YHWDL Sbjct: 66 QLLKSLGIKSYRFSIAWPRIFPKGFGEI-NQKGIQFYRDLIDELIKNDIEPAITIYHWDL 124 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P LQ+ GGW N + D + DYA F+ FGDRVK WIT + P++ ++ GY G+HAPG Sbjct: 125 PQKLQD-IGGWANPQVADYYVDYANLLFREFGDRVKTWITHNEPWVASYLGYALGVHAPG 183 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K ++ HN++ +H K Y Q G + ITL N S + DI Sbjct: 184 IK-DMKMALLAAHNILLSHFKAVKAYR---ELEQDGQIGITLNLSTCYSN-SADEEDIAA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKH---EMRGTADFFAFSFG 375 +S WF + G YPE M K+FS I E K E+ T+DF ++ Sbjct: 239 AHRSDGWNNRWFLDAAL-KGTYPEDM-IKIFSDTNIMPELPKELFTEVFETSDFLGINYY 296 Query: 376 PNNFKPLNTMAKMG-QNVSLN--------------LREALNWIKLEYNNPRILIAENGWF 420 N+ A +G ++V+++ L + L I +Y N + I ENG Sbjct: 297 TRQVVKNNSEAFIGAESVAMDNPKTEMGWEIYPQGLYDLLTRIHRDYGNIDLYITENGAA 356 Query: 421 TDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRR 476 + V K ED + + + L AI + + GY WS +D FEW + Y R Sbjct: 357 FNDMVNRDGKVEDENRLDYLYTHFAAALSAIEAG-VPLKGYYIWSFMDNFEWAEGYEKRF 415 Query: 477 GLFYVDFNSKQKERKPKSSAHYYKQIIR 504 G+ +V N K +ER K SA++YK++I Sbjct: 416 GIVHV--NYKTQERTIKKSAYWYKELIE 441 Score = 132 bits (332), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 119/474 (25%), Positives = 209/474 (44%), Gaps = 67/474 (14%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGV-RLKTRPAQCTD 578 +FP DF +G + + E + + +W+ R H V ++ C Sbjct: 5 RFPKDFIFGTATAAYQIEGAYKEDEKGES---IWD----RFSHIPGNVAKMHNGDIACDH 57 Query: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638 + K+ +++L + + YRF++ W + P G +N++ +++YR ++ E +K I Sbjct: 58 YHRYKEDVQLLKSLGIKSYRFSIAWPRIFPKG-FGEINQKGIQFYRDLIDELIKNDIEPA 116 Query: 639 VTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 +T+Y H LP+ L GW NP A+ + YA L F+E GD VK WIT NEP S Sbjct: 117 ITIY-----HWDLPQKLQDIGGWANPQVADYYVDYANLLFREFGDRVKTWITHNEPWVAS 171 Query: 699 DIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 + G G AAHN+L++H A + Y R+ + ++L+L ++ Sbjct: 172 YLGYALGVHAPGIKDMKMALLAAHNILLSHFKAVKAY-RELEQDGQIGITLNLSTCYSNS 230 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 A+ + AA R + WF + K G YP M + + ++ +P L + Sbjct: 231 AD---EEDIAAAHRSDGWNNRWFLDAALK-GTYPEDMIKIFS-------DTNIMPELPKE 279 Query: 810 ERRLLKGTVDFCALNHFTTRFVMH--EQLAGSRYDSDRDIQFLQDITRLSSPTRLA--VI 865 + T DF +N++T + V + E G+ + + + T + + Sbjct: 280 LFTEVFETSDFLGINYYTRQVVKNNSEAFIGA-----------ESVAMDNPKTEMGWEIY 328 Query: 866 PWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYLQEVLKAYL 919 P G+ LL + R+YG++D+YIT +G ++ +D R YL + L A + Sbjct: 329 PQGLYDLLTRIHRDYGNIDLYITENGAAFNDMVNRDGKVEDENRLDYLYTHFAAALSA-I 387 Query: 920 IDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 V +KGYY + + E + RFG ++K K S +Y ++I Sbjct: 388 EAGVPLKGYYIWSFMDNFEWAEGYEKRFGIVHVNYKTQERTIKKSAYWYKELIE 441 >1E55-A nrPDB Length = 512 Score = 231 bits (589), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 169/512 (33%), Positives = 248/512 (48%), Gaps = 79/512 (15%) Query: 70 VNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNG 126 ++ S++ D FP +F +G T A Q+EG+W +DGKG S WDHF H H + + S+++ Sbjct: 13 LSPSEIPQRDWFPSDFTFGAATSAYQIEGAWNEDGKGESNWDHFCHNHPERILDGSNSDI 72 Query: 127 SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLR 185 ++SY + D+ L +G+ Y+FSISWPR+ P G N G++YY L++ L+ Sbjct: 73 GANSYHMYKTDVRLLKEMGMDAYRFSISWPRILPKGTKEGGINPDGIKYYRNLINLLLEN 132 Query: 186 NIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDY---ATYCFQMFGDRVKYWITIHNP 242 IEP VT++HWD+P AL+EKYGG+ + + I DY A CF FGD+VK W+T ++P Sbjct: 133 GIEPYVTIFHWDVPQALEEKYGGFLDKSHKSIVEDYTYFAKVCFDNFGDKVKNWLTFNDP 192 Query: 243 YLVAWHGYGTGMHAPGE----------KGN-LAAVYTVGHNLIKAHSKVWHNYNTHF-RP 290 YGTG+ APG GN L YT GHN++ AH++ YN H+ R Sbjct: 193 QTFTSFSYGTGVFAPGRCSPGLDCAYPTGNSLVEPYTAGHNILLAHAEAVDLYNKHYKRD 252 Query: 291 HQKGWLS------ITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGM 344 + L+ + G+ +++ E + DI LGWF P+ GDYP M Sbjct: 253 DTRIGLAFDVMGRVPYGTSFLDKQAEERSWDI---------NLGWFLEPVV-RGDYPFSM 302 Query: 345 RKKLFSVLPIFSEAEKHEMRGTADFFAFSF-----------GPNNFKPLNTM-AKMGQNV 392 R LP F + +K ++ G+ + ++ PN LNT A Q V Sbjct: 303 RSLARERLPFFKDEQKEKLAGSYNMLGLNYYTSRFSKNIDISPNYSPVLNTDDAYASQEV 362 Query: 393 S--------------------LNLREALNWIKLEYNNPRILIAENGWFTDSRVKT----- 427 + L++ L +K +Y NP I I ENG D K Sbjct: 363 NGPDGKPIGPPMGNPWIYMYPEGLKDLLMIMKNKYGNPPIYITENG-IGDVDTKETPLPM 421 Query: 428 ----EDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDF 483 D + ++ ++ + ++I L V GY AWSLLD FEW +T R G+ YVD Sbjct: 422 EAALNDYKRLDYIQRHIATLKESIDLGS-NVQGYFAWSLLDNFEWFAGFTERYGIVYVDR 480 Query: 484 NSKQKERKPKSSAHYYKQIIRENGFSLKESTP 515 N+ R K SA + K+ S K TP Sbjct: 481 NNNCT-RYMKESAKWLKEFNTAKKPSKKILTP 511 Score = 124 bits (312), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 106/401 (26%), Positives = 180/401 (44%), Gaps = 68/401 (16%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGISAMVTL 641 K + +L M + YRF++ W +LP G +N ++YYR +++ L+ GI VT+ Sbjct: 81 KTDVRLLKEMGMDAYRFSISWPRILPKGTKEGGINPDGIKYYRNLINLLLENGIEPYVTI 140 Query: 642 YYPTHAHLGLPEPLLHADGWL----NPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697 + H +P+ L G + S E + +A +CF GD VK W+T N+P Sbjct: 141 F-----HWDVPQALEEKYGGFLDKSHKSIVEDYTYFAKVCFDNFGDKVKNWLTFNDPQTF 195 Query: 698 S------------------DIYNRSGN---DTYGAAHNLLVAHALAWRLYDRQFRPSQRG 736 + D +GN + Y A HN+L+AHA A LY++ ++ R Sbjct: 196 TSFSYGTGVFAPGRCSPGLDCAYPTGNSLVEPYTAGHNILLAHAEAVDLYNKHYK---RD 252 Query: 737 AVSLSLHADWAEPANPYADSHW--RAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKH 794 + L D PY S +A ER + WF EP+ + GDYP +MR Sbjct: 253 DTRIGLAFDVMGRV-PYGTSFLDKQAEERSWDINLGWFLEPVVR-GDYPFSMRS------ 304 Query: 795 RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAG--SRYDSDRDIQFLQD 852 L+ LP + ++ L G+ + LN++T+RF + ++ S + D Q+ Sbjct: 305 ---LARERLPFFKDEQKEKLAGSYNMLGLNYYTSRFSKNIDISPNYSPVLNTDDAYASQE 361 Query: 853 IT-----RLSSPTR---LAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD---------- 894 + + P + + P G++ LL ++ YG+ IYIT +GI D Sbjct: 362 VNGPDGKPIGPPMGNPWIYMYPEGLKDLLMIMKNKYGNPPIYITENGIGDVDTKETPLPM 421 Query: 895 QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE 935 +A +D R Y+ +++ LK + ++GY+A+ L + Sbjct: 422 EAALNDYKRLDYIQRHIA-TLKESIDLGSNVQGYFAWSLLD 461 >1BGG-A nrPDB Length = 448 Score = 230 bits (586), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 156/450 (34%), Positives = 231/450 (51%), Gaps = 37/450 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FP++F WG T A Q+EG++++DG+G SIWD F HT K + NG + DSY E+D+ Sbjct: 6 FPQDFMWGTATAAYQIEGAYQEDGRGLSIWDTFAHTPGKVFNGDNGNVACDSYHRYEEDI 65 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FS+SWPR+FP+G V N +GL YY ++D L IEP TLYHWDL Sbjct: 66 RLMKELGIRTYRFSVSWPRIFPNGDGEV-NQEGLDYYHRVVDLLNDNGIEPFCTLYHWDL 124 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ+ GGW N I F +A F+ F ++++W+T + P+ +A+ G+HAPG Sbjct: 125 PQALQDA-GGWGNRRTIQAFVQFAETMFREFHGKIQHWLTFNEPWCIAFLSNMLGVHAPG 183 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 NL VGH+L+ AH + G + I W P S + D Sbjct: 184 LT-NLQTAIDVGHHLLVAHGLSVRRFR---ELGTSGQIGIAPNVSWAVP-YSTSEEDKAA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRK---KLFSVLPIFSEAEKHEMRGTADFFA---F 372 C +++ WF PI+ G YP+ + + + +PI + + + D + Sbjct: 239 CARTISLHSDWFLQPIY-QGSYPQFLVDWFAEQGATVPI-QDGDMDIIGEPIDMIGINYY 296 Query: 373 SFGPNNFKP-----LNTMAKMGQNV--------SLNLREALNWIKLEYNNPRILIAENGW 419 S N F P + MG V S L E L++++ +Y N I I ENG Sbjct: 297 SMSVNRFNPEAGFLQSEEINMGLPVTDIGWPVESRGLYEVLHYLQ-KYGNIDIYITENGA 355 Query: 420 FTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRR 476 + V K +D I M+ L QV + I D + V GY AWSLLD FEW + Y +R Sbjct: 356 CINDEVVNGKVQDDRRISYMQQHLVQVHRTIH-DGLHVKGYMAWSLLDNFEWAEGYNMRF 414 Query: 477 GLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 G+ +VDF + + R PK S ++Y+ ++ N Sbjct: 415 GMIHVDF--RTQVRTPKESYYWYRNVVSNN 442 Score = 137 bits (344), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 120/470 (25%), Positives = 213/470 (45%), Gaps = 58/470 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 QFP DF WG + + E + Q L +W+ + G C + Sbjct: 5 QFPQDFMWGTATAAYQIEG---AYQEDGRGLSIWDTFAHTPGKVFNG---DNGNVACDSY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ + ++ + + YRF++ W + P G+ VN++ L YY VV GI Sbjct: 59 HRYEEDIRLMKELGIRTYRFSVSWPRIFPNGD-GEVNQEGLDYYHRVVDLLNDNGIEPFC 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+ L A GW N T +AF +A F+E ++ W+T NEP ++ Sbjct: 118 TLY-----HWDLPQALQDAGGWGNRRTIQAFVQFAETMFREFHGKIQHWLTFNEPWCIAF 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + N G G H+LLVAH L+ R + R+ S G + ++ + WA P Sbjct: 173 LSNMLGVHAPGLTNLQTAIDVGHHLLVAHGLSVRRF-RELGTS--GQIGIAPNVSWAVPY 229 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + + A R + WF +P+++ G YP + ++ A + + +P + + + Sbjct: 230 STSEEDK-AACARTISLHSDWFLQPIYQ-GSYPQFLVDWFAEQ------GATVP-IQDGD 280 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 ++ +D +N+++ AG + +I +T + P G+ Sbjct: 281 MDIIGEPIDMIGINYYSMSVNRFNPEAG--FLQSEEINMGLPVTDIGWPVESR----GLY 334 Query: 871 KLLRWVRRNYGDMDIYITASG--IDDQA----LEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 ++L ++++ YG++DIYIT +G I+D+ ++DDR R Y+ ++L +V + + D + Sbjct: 335 EVLHYLQK-YGNIDIYITENGACINDEVVNGKVQDDR-RISYMQQHLVQVHRT-IHDGLH 391 Query: 925 IKGYYAFKLAE-----EKSKPRFGFFTSDFKA-----KSSIQFYNKVISS 964 +KGY A+ L + E RFG DF+ K S +Y V+S+ Sbjct: 392 VKGYMAWSLLDNFEWAEGYNMRFGMIHVDFRTQVRTPKESYYWYRNVVSN 441 >1QOX-A nrPDB Length = 449 Score = 228 bits (580), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 155/457 (33%), Positives = 229/457 (50%), Gaps = 39/457 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP +F WG+ T A Q+EG++ +DG+G SIWD F HT +KN + N + DSY +E+D+ Sbjct: 5 FPSDFKWGVATAAYQIEGAYNEDGRGMSIWDTFAHTPGKVKNGDNGNVACDSYHRVEEDV 64 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +GV Y+FSISWPR+ P G V N GL YY L+D L+ IEP TLYHWDL Sbjct: 65 QLLKDLGVKVYRFSISWPRVLPQGTGEV-NRAGLDYYHRLVDELLANGIEPFCTLYHWDL 123 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ++ GGW + ID F +YA F+ G ++K WIT + P+ +A+ G+HAPG Sbjct: 124 PQALQDQ-GGWGSRITIDAFAEYAELMFKELGGKIKQWITFNEPWCMAFLSNYLGVHAPG 182 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQ-KGWLSITLGSHWIEPNRSENTMDIF 317 K +L V H+L+ AH + T FR G + I + W P R D+ Sbjct: 183 NK-DLQLAIDVSHHLLVAHGRA----VTLFRELGISGEIGIAPNTSWAVPYRRTKE-DME 236 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRK--KLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 C + W+ +PI+ G+YP+ M + P + + + DF ++ Sbjct: 237 ACLRVNGWSGDWYLDPIYF-GEYPKFMLDWYENLGYKPPIVDGDMELIHQPIDFIGINYY 295 Query: 376 PNNFKPLNTMAKMG----QNVSL--------------NLREALNWIKLEYNNPRILIAEN 417 ++ N G + +S+ L + L + +Y NP + I EN Sbjct: 296 TSSMNRYNPGEAGGMLSSEAISMGAPKTDIGWEIYAEGLYDLLRYTADKYGNPTLYITEN 355 Query: 418 GWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYT 473 G + + + D I + L Q +AI D I + GY WSL+D FEW + Y Sbjct: 356 GACYNDGLSLDGRIHDQRRIDYLAMHLIQASRAIE-DGINLKGYMEWSLMDNFEWAEGYG 414 Query: 474 IRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 +R GL +VD+++ R PK S ++YK +I L Sbjct: 415 MRFGLVHVDYDTLV--RTPKDSFYWYKGVISRGWLDL 449 Score = 138 bits (348), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 128/472 (27%), Positives = 207/472 (43%), Gaps = 62/472 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP DF WGV + + E + + +W+ + G C + Sbjct: 5 FPSDFKWGVATAAYQIEGAYNEDGRG---MSIWDTFAHTPGKVKNG---DNGNVACDSYH 58 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 +++ +++L + V YRF++ W VLP G VNR L YY +V E L GI T Sbjct: 59 RVEEDVQLLKDLGVKVYRFSISWPRVLPQGT-GEVNRAGLDYYHRLVDELLANGIEPFCT 117 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GW + T +AF YA L F+ELG +K WIT NEP ++ + Sbjct: 118 LY-----HWDLPQALQDQGGWGSRITIDAFAEYAELMFKELGGKIKQWITFNEPWCMAFL 172 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 N G G +H+LLVAH A L+ R+ S G + ++ + WA P Sbjct: 173 SNYLGVHAPGNKDLQLAIDVSHHLLVAHGRAVTLF-RELGIS--GEIGIAPNTSWAVPYR 229 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 + A R + W+ +P++ G+YP M ++ + + P + + + Sbjct: 230 RTKEDM-EACLRVNGWSGDWYLDPIY-FGEYPKFMLDWYENLGYK-------PPIVDGDM 280 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL--QDITRLSSPTRLA--VIPW 867 L+ +DF +N++T+ +RY+ L + I+ + T + + Sbjct: 281 ELIHQPIDFIGINYYTSSM--------NRYNPGEAGGMLSSEAISMGAPKTDIGWEIYAE 332 Query: 868 GVRKLLRWVRRNYGDMDIYITASGI---DDQALED---DRLRKYYLGKYLQEVLKAYLID 921 G+ LLR+ YG+ +YIT +G D +L+ D+ R YL +L + +A + D Sbjct: 333 GLYDLLRYTADKYGNPTLYITENGACYNDGLSLDGRIHDQRRIDYLAMHLIQASRA-IED 391 Query: 922 KVRIKGYYAFKLAE-----EKSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 + +KGY + L + E RFG D+ K S +Y VIS Sbjct: 392 GINLKGYMEWSLMDNFEWAEGYGMRFGLVHVDYDTLVRTPKDSFYWYKGVIS 443 >1W9D-M nrPDB Length = 501 Score = 224 bits (572), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 148/474 (31%), Positives = 226/474 (47%), Gaps = 64/474 (13%) Query: 88 GIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG----SSDSYIFLEKDLSALDF 143 G+ + A Q+EG+ G+G +IWD F H + +G + DS+ + +KD+ LD Sbjct: 32 GVASSAYQIEGTI---GRGLNIWDGFTHRYPNKSGPDHGNGDTTCDSFSYWQKDIDVLDE 88 Query: 144 IGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLAL 202 + + Y+FSI+W R+ P G + N KG+ YY L+ L+ + I P VTL+HWDLP L Sbjct: 89 LNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLFHWDLPQTL 148 Query: 203 QEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGE--- 259 Q++Y G+ + IID F DYA CF+ FGD VKYW+TI+ Y V GYG+ + APG Sbjct: 149 QDEYEGFLDPQIIDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSP 208 Query: 260 -------KGNLAA-VYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSE 311 GN + Y V H+ + AH+KV Y ++ HQ G + T+ + W P Sbjct: 209 TVDPSCYAGNSSTEPYIVAHHQLLAHAKVVDLYRKNYT-HQGGKIGPTMITRWFLPYNDT 267 Query: 312 NTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFA 371 + I ++ LGWF P+ +G YP+ M + LP FS E + ++G+ DF Sbjct: 268 DRHSIAATERMKEFFLGWFMGPLT-NGTYPQIMIDTVGERLPSFSPEESNLVKGSYDFLG 326 Query: 372 FSF--------GPNNFKPLNTMAKMGQNVSLNLREA------------------------ 399 ++ PN N A M L A Sbjct: 327 LNYYFTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYP 386 Query: 400 ------LNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVL----QAIRL 449 +++ K +Y NP I + ENG T + Y ++L L + I+ Sbjct: 387 KGIYSVMDYFKNKYYNPLIYVTENGISTPGDENRNQSMLDYTRIDYLCSHLCFLNKVIKE 446 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 ++ V GY AW+L D +E+ +T+R GL Y+D+N+ +R K S +Y+ I Sbjct: 447 KDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDWNN-VTDRDLKKSGQWYQSFI 499 Score = 148 bits (374), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 130/470 (27%), Positives = 204/470 (43%), Gaps = 73/470 (15%) Query: 550 LYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPT 609 L +W+ +R ++ G C F +K +++L + T YRF++ W+ ++P Sbjct: 48 LNIWDGFTHRYPNK-SGPDHGNGDTTCDSFSYWQKDIDVLDELNATGYRFSIAWSRIIPR 106 Query: 610 GNLS-AVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTA 667 G S VN + + YY ++S +K GI+ VTL+ H LP+ L +G+L+P Sbjct: 107 GKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLF-----HWDLPQTLQDEYEGFLDPQII 161 Query: 668 EAFQAYAGLCFQELGDLVKLWITINE---------------PNRLSDIYNRS---GNDT- 708 + F+ YA LCF+E GD VK W+TIN+ P R S + S GN + Sbjct: 162 DDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSPTVDPSCYAGNSST 221 Query: 709 --YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQ 766 Y AH+ L+AHA LY + + Q G + ++ W P N A ER + Sbjct: 222 EPYIVAHHQLLAHAKVVDLYRKNYT-HQGGKIGPTMITRWFLPYNDTDRHSIAATERMKE 280 Query: 767 FEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHF 826 F + WF PL G YP M + + + LP + E L+KG+ DF LN++ Sbjct: 281 FFLGWFMGPL-TNGTYPQIMIDTVGER---------LPSFSPEESNLVKGSYDFLGLNYY 330 Query: 827 TTRFVM----------HEQL--AGSRYD----SDRDIQFLQDITRLSSPTRLAVIPWGVR 870 T++ H + AG++ S I L + + S + P G+ Sbjct: 331 FTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYPKGIY 390 Query: 871 KLLRWVRRNYGDMDIYITASGIDDQALED------DRLRKYYLGKYLQEVLKAYLIDKVR 924 ++ + + Y + IY+T +GI E+ D R YL +L + K V Sbjct: 391 SVMDYFKNKYYNPLIYVTENGISTPGDENRNQSMLDYTRIDYLCSHLCFLNKVIKEKDVN 450 Query: 925 IKGYYAFKLAEEKS-----KPRFGFF------TSDFKAKSSIQFYNKVIS 963 +KGY A+ L + RFG +D K S Q+Y IS Sbjct: 451 VKGYLAWALGDNYEFNKGFTVRFGLSYIDWNNVTDRDLKKSGQWYQSFIS 500 >4PTW-A nrPDB Length = 452 Score = 212 bits (539), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 146/452 (32%), Positives = 221/452 (48%), Gaps = 39/452 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP++F WG T + Q+EG++ +DGKG SIWD F HT ++N + + + D Y +D+ Sbjct: 7 FPEDFIWGAATSSYQIEGAFNEDGKGESIWDRFSHTPGKIENGDTGDIACDHYHLYREDI 66 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + IG+ Y+FS SWPR+ P+G V N KGL +Y L+D L+ NI P++TLYHWDL Sbjct: 67 ELMKEIGIRSYRFSTSWPRILPEGKGRV-NQKGLDFYKRLVDNLLKANIRPMITLYHWDL 125 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ+K GGW N F +YA F+ F V W+T + P++VA+ G+ G HAPG Sbjct: 126 PQALQDK-GGWTNRDTAKYFAEYARLMFEEFNGLVDLWVTHNEPWVVAFEGHAFGNHAPG 184 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K + V H+L+ +H + P G + ITL P ++ D+ Sbjct: 185 TK-DFKTALQVAHHLLLSHGMAVDIFREEDLP---GEIGITLNLTPAYP-AGDSEKDVKA 239 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSE--AEKHEMRGTADFFAFSF-- 374 + WF +P+ G YPE + L F+ + + DF ++ Sbjct: 240 ASLLDDYINAWFLSPVF-KGSYPEELHHIYEQNLGAFTTQPGDMDIISRDIDFLGINYYS 298 Query: 375 --------GPNNFKPLNTMAKMGQNVSLN---------LREALNWIKLEYNNPRILIAEN 417 G N F + KM S L + L + EY + + I EN Sbjct: 299 RMVVRHKPGDNLFNA--EVVKMEDRPSTEMGWEIYPQGLYDILVRVNKEYTDKPLYITEN 356 Query: 418 GWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYT 473 G D ++ K D I + + Q +A++ D + + GY WSL+D FEW Y+ Sbjct: 357 GAAFDDKLTEEGKIHDEKRINYLGDHFKQAYKALK-DGVPLRGYYVWSLMDNFEWAYGYS 415 Query: 474 IRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 R GL YVD+ + + R K SA +Y+++I + Sbjct: 416 KRFGLIYVDYENGNR-RFLKDSALWYREVIEK 446 Score = 148 bits (374), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 130/472 (27%), Positives = 213/472 (45%), Gaps = 62/472 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVR-LKTRPAQCTDF 579 FP DF WG S + E + + +W+ R H + T C + Sbjct: 7 FPEDFIWGAATSSYQIEGAFNEDGKGES---IWD----RFSHTPGKIENGDTGDIACDHY 59 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ +E++ + + YRF+ W +LP G VN++ L +Y+ +V LK I M+ Sbjct: 60 HLYREDIELMKEIGIRSYRFSTSWPRILPEGK-GRVNQKGLDFYKRLVDNLLKANIRPMI 118 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+ L GW N TA+ F YA L F+E LV LW+T NEP ++ Sbjct: 119 TLY-----HWDLPQALQDKGGWTNRDTAKYFAEYARLMFEEFNGLVDLWVTHNEPWVVAF 173 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + GN G AH+LL++H +A ++ + P + G ++L+L PA Sbjct: 174 EGHAFGNHAPGTKDFKTALQVAHHLLLSHGMAVDIFREEDLPGEIG-ITLNL-----TPA 227 Query: 751 NPYADSH--WRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE 808 P DS +AA + AWF P+FK G YP + +I ++ ++ Sbjct: 228 YPAGDSEKDVKAASLLDDYINAWFLSPVFK-GSYPEELH-HIYEQNLGAFTTQP------ 279 Query: 809 AERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWG 868 + ++ +DF +N+++ V H+ D+ + + ++ R S+ + P G Sbjct: 280 GDMDIISRDIDFLGINYYSRMVVRHKPG-----DNLFNAEVVKMEDRPSTEMGWEIYPQG 334 Query: 869 VRKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLIDK 922 + +L V + Y D +YIT +G DD+ E+ D R YLG + ++ KA L D Sbjct: 335 LYDILVRVNKEYTDKPLYITENGAAFDDKLTEEGKIHDEKRINYLGDHFKQAYKA-LKDG 393 Query: 923 VRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------AKSSIQFYNKVIS 963 V ++GYY + L + RFG D++ K S +Y +VI Sbjct: 394 VPLRGYYVWSLMDNFEWAYGYSKRFGLIYVDYENGNRRFLKDSALWYREVIE 445 >4ZEN-A nrPDB Length = 485 Score = 207 bits (526), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 152/478 (31%), Positives = 225/478 (47%), Gaps = 56/478 (11%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FP F WG + A QVEG+W +DGKG S+WD F + TNG + D Y ++D+ Sbjct: 16 FPPEFLWGAASAAYQVEGAWNEDGKGLSVWDVFAKQPGRTFKGTNGDVAVDHYHRYQEDV 75 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + + +G+ Y+FS+SW R+FPDG V N KGL +Y L++ L IEPIVTLYHWD+ Sbjct: 76 ALMAEMGLKAYRFSVSWSRVFPDGNGAV-NEKGLDFYDRLIEELRNHGIEPIVTLYHWDV 134 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P AL + YG W++ IID F+ YA FQ FGDRVKYW+T++ + GY G+H PG Sbjct: 135 PQALMDAYGAWESRRIIDDFDRYAVTLFQRFGDRVKYWVTLNEQNIFISFGYRLGLHPPG 194 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K ++ +Y H A++KV ++ H+ P K S + +R EN + Sbjct: 195 VK-DMKRMYEANHIANLANAKVIQSFR-HYVPDGKIGPSFAYSPMYPYDSRPENVLAFEN 252 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS--VLPIFSEAEKHEMRGT-ADFFAFSF- 374 ++ W+ + ++ G YP+ L S + P + + ++ DF ++ Sbjct: 253 AEEFQNH---WWMD-VYAWGMYPQAAWNYLESQGLEPTVAPGDWELLQAAKPDFMGVNYY 308 Query: 375 --------GPNNFKP--LNTMAKMGQNVS--------------------------LNLRE 398 P+ +NT K G + S + LR Sbjct: 309 QTTTVEHNPPDGVGEGVMNTTGKKGTSTSSGIPGLFKTVRNPHVDTTNWDWAIDPVGLRI 368 Query: 399 ALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIR---LDEIRVF 455 L I Y P ILI ENG ++ D ++L + +Q I+ D + V Sbjct: 369 GLRRIANRYQLP-ILITENGLGEFDTLEPGDIVNDDYRIDYLRRHVQEIQRAITDGVDVL 427 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYV---DFNSKQKERKPKSSAHYYKQIIRENGFSL 510 GY AWS D W + Y R G YV D + K R K S ++Y+++I NG L Sbjct: 428 GYCAWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKKSFYWYQRVIETNGAEL 485 Score = 102 bits (253), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 126/494 (25%), Positives = 199/494 (40%), Gaps = 75/494 (15%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP +F WG + + E + L VW+ + +G + Sbjct: 16 FPPEFLWGAASAAYQVEGAWNE---DGKGLSVWDVFAKQPGRTFKGT---NGDVAVDHYH 69 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ + ++A M + YRF++ W+ V P GN AVN + L +Y ++ E GI +VT Sbjct: 70 RYQEDVALMAEMGLKAYRFSVSWSRVFPDGN-GAVNEKGLDFYDRLIEELRNHGIEPIVT 128 Query: 641 LYYPTHAHLGLPEPLLHADG-WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 LY H +P+ L+ A G W + + F YA FQ GD VK W+T+NE N Sbjct: 129 LY-----HWDVPQALMDAYGAWESRRIIDDFDRYAVTLFQRFGDRVKYWVTLNEQNIFIS 183 Query: 700 IYNRSG---------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 R G Y A H +A+A + + R + P + S + P Sbjct: 184 FGYRLGLHPPGVKDMKRMYEANHIANLANAKVIQSF-RHYVPDGKIGPSFAY-----SPM 237 Query: 751 NPYAD--SHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE 808 PY + A E +F+ W+ + ++ G YP A Y+ S+ GL + P E Sbjct: 238 YPYDSRPENVLAFENAEEFQNHWWMD-VYAWGMYPQAAWNYLESQ---GLEPTVAPGDWE 293 Query: 809 AERRLLKGTVDFCALNHFTTRFVMHEQLAG-----SRYDSDRDIQFLQDITRLSSPTR-- 861 L DF +N++ T V H G + I L R Sbjct: 294 L---LQAAKPDFMGVNYYQTTTVEHNPPDGVGEGVMNTTGKKGTSTSSGIPGLFKTVRNP 350 Query: 862 --------LAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD-QALE-----DDRLRKYYL 907 A+ P G+R LR + Y + I IT +G+ + LE +D R YL Sbjct: 351 HVDTTNWDWAIDPVGLRIGLRRIANRY-QLPILITENGLGEFDTLEPGDIVNDDYRIDYL 409 Query: 908 GKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFF--------TSDFK--AK 952 +++QE+ +A + D V + GY A+ + S + R+GF D + K Sbjct: 410 RRHVQEIQRA-ITDGVDVLGYCAWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKK 468 Query: 953 SSIQFYNKVISSRG 966 S +Y +VI + G Sbjct: 469 KSFYWYQRVIETNG 482 >5XGZ-A nrPDB Length = 457 Score = 206 bits (523), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 132/456 (28%), Positives = 223/456 (48%), Gaps = 32/456 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGS--SDSYIFLEKDL 138 FP +F WG+ T + Q+EG+ + DG+ PSIWD F + G+ +D Y +D+ Sbjct: 10 FPPDFQWGVATSSYQIEGAVEADGRSPSIWDTFCARPGAIADGSTGAIANDHYHRYREDI 69 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + + +GV+ Y+FSI+WPR+ PDG V N G+ +Y L+D+L+ + IEP TLYHWD+ Sbjct: 70 AIMKQLGVNAYRFSIAWPRILPDGRGRV-NQAGVDFYERLVDSLLEQGIEPYATLYHWDM 128 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P +Q W + ++D F +Y + DRVKYW+T++ P+++++ GYG G HAPG Sbjct: 129 P-QVQHDRTPWYDRGVVDAFVEYTDVITRRLSDRVKYWMTLNEPWVISFLGYGAGEHAPG 187 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + + H+++ AH K + K I L +W+ S++ D Sbjct: 188 LR-DKELYLRAAHHVLLAHGKAMPVIRANGNAQTKA--GIVLNLNWVN-AASDSPEDQAA 243 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ WFA P++ +G YPE + + L + + DF A ++ Sbjct: 244 ARRYDQFFNRWFAEPLY-NGRYPEELLEWYGRDLVPVQPGDFDIITTPTDFLAVNYYART 302 Query: 379 FKPLNTMAKM---------GQNVSLN-------LREALNWIKLEYNNPRILIAENGWFTD 422 + M G+ +++ L LNW+ +Y P + + ENG D Sbjct: 303 TVKAGSTDPMLQVDFVRPPGEYTAMDWEVYPQGLYNILNWLHTDYAPPALYVTENGAAYD 362 Query: 423 SRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 +V + +D + ++ +AI+ I + GY WSL+D FEW + R G+ Sbjct: 363 DQVSAAGEVDDPQRLAYLEGHFEAAYRAIQAG-IPLKGYFVWSLMDNFEWGRGFEKRFGI 421 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKEST 514 +VD+ ++Q R K S ++ Q+ R NG ++T Sbjct: 422 VFVDYATQQ--RIIKRSGKWFSQVTRANGLPAPQTT 455 Score = 121 bits (303), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 119/486 (24%), Positives = 206/486 (42%), Gaps = 57/486 (11%) Query: 513 STPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTR 572 ST + +FP DF WGV S + E + S +W+ R +G T Sbjct: 2 STQNEPHRFPPDFQWGVATSSYQIEGAVEADGRSPS---IWDTFCARPGAIADG---STG 55 Query: 573 PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 + ++ + ++ ++ V YRF++ W +LP G VN+ + +Y +V L+ Sbjct: 56 AIANDHYHRYREDIAIMKQLGVNAYRFSIAWPRILPDGR-GRVNQAGVDFYERLVDSLLE 114 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI TLY H +P+ W + +AF Y + + L D VK W+T+N Sbjct: 115 QGIEPYATLY-----HWDMPQVQHDRTPWYDRGVVDAFVEYTDVITRRLSDRVKYWMTLN 169 Query: 693 EPNRLSDIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLH 743 EP +S + +G G AAH++L+AH A + + + L+L Sbjct: 170 EPWVISFLGYGAGEHAPGLRDKELYLRAAHHVLLAHGKAMPVIRANGNAQTKAGIVLNL- 228 Query: 744 ADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSAL 803 +W A+ + AA R+ QF WFAEPL+ G YP + E+ L Sbjct: 229 -NWVNAASDSPEDQ-AAARRYDQFFNRWFAEPLYN-GRYPEELLEWYGRD---------L 276 Query: 804 PRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLA 863 + + ++ DF A+N++ V AGS D + F++ ++ Sbjct: 277 VPVQPGDFDIITTPTDFLAVNYYARTTVK----AGST-DPMLQVDFVRPPGEYTA-MDWE 330 Query: 864 VIPWGVRKLLRWVRRNYGDMDIYITASGI--DDQALE----DDRLRKYYLGKYLQEVLKA 917 V P G+ +L W+ +Y +Y+T +G DDQ DD R YL + + +A Sbjct: 331 VYPQGLYNILNWLHTDYAPPALYVTENGAAYDDQVSAAGEVDDPQRLAYLEGHFEAAYRA 390 Query: 918 YLIDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDFKAKSSI-----QFYNKVISSRGF 967 + + +KGY+ + L + + RFG D+ + I +++++V + G Sbjct: 391 -IQAGIPLKGYFVWSLMDNFEWGRGFEKRFGIVFVDYATQQRIIKRSGKWFSQVTRANGL 449 Query: 968 PFENSS 973 P ++ Sbjct: 450 PAPQTT 455 >5GNX-A nrPDB Length = 467 Score = 202 bits (514), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 142/459 (30%), Positives = 222/459 (48%), Gaps = 45/459 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG T A Q+EGS DG G SIWD F HT ++K+ + + + D Y +D+ Sbjct: 14 FPEGFLWGAATAAYQIEGSSMADGAGESIWDRFSHTPGNMKDGDTGDVACDHYNRWREDI 73 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + + + Y+FS+SW R+ P G + N KGL +Y L+D L+ IEP+ TLYHWDL Sbjct: 74 ELMKRLNLQAYRFSVSWSRVIPQGRGAI-NPKGLAFYDRLVDGLLEAGIEPLATLYHWDL 132 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P AL ++ GGW N I D F DY F+ F RVK W TI+ P+++ GY G APG Sbjct: 133 PAALDDR-GGWLNPDIADWFADYGQVLFEKFKGRVKTWGTINQPWVIVDGGYLHGALAPG 191 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPN--RSENTMDI 316 + AV GHN+++AH FR +G + I L IEP S+ D Sbjct: 192 HRSAYEAV-IAGHNVLRAHGAA----VRRFREVGEGQIGIVLN---IEPKYPASDKPEDE 243 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSF-- 374 +++ + WF +P+ G G YPE + + F + + + D+ ++ Sbjct: 244 AARRRAEAQMNRWFLDPLMGRG-YPEELTDVYGAAWREFPKEDFELIAEPTDWMGLNWYT 302 Query: 375 ------GPNNFKPLNTMAKMGQNVSLN---------LREALNWIKLEYNNP-RILIAENG 418 P+ + + + Q+ L + L W+ + +++ ENG Sbjct: 303 RAVPENAPDAWPTRSRPVRQTQHAHTETGWEVYPPALTDTLVWLSEQTGGKLPLMVTENG 362 Query: 419 --WF-----TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 W+ D R+ D ++ ++ + + AI + + GY AWSLLD EW Sbjct: 363 SAWYDPPHAIDGRI--HDPMRVHYLQTHIKALHDAIG-KGVDLRGYMAWSLLDNLEWSLG 419 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 Y+ R G+ +V+F + +ER K S Y ++I+ +G L Sbjct: 420 YSKRFGIVHVNFAT--QERTIKDSGLLYAEVIKTHGDVL 456 Score = 110 bits (275), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 120/475 (25%), Positives = 197/475 (41%), Gaps = 62/475 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WG + + E + + + +W+ + + +G T C + Sbjct: 13 RFPEGFLWGAATAAYQIEGSSMADGAGES---IWDRFSHTPGNMKDG---DTGDVACDHY 66 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ +E++ R+ + YRF++ W+ V+P G A+N + L +Y +V L+ GI + Sbjct: 67 NRWREDIELMKRLNLQAYRFSVSWSRVIPQGR-GAINPKGLAFYDRLVDGLLEAGIEPLA 125 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP L GWLNP A+ F Y + F++ VK W TIN+P + D Sbjct: 126 TLY-----HWDLPAALDDRGGWLNPDIADWFADYGQVLFEKFKGRVKTWGTINQPWVIVD 180 Query: 700 ---------IYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 +RS + A HN+L AH A R+FR G + + L+ EP Sbjct: 181 GGYLHGALAPGHRSAYEAVIAGHNVLRAHGAA----VRRFREVGEGQIGIVLN---IEPK 233 Query: 751 NPYADS-HWRAAERFLQFEI-AWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTE 808 P +D AA R + ++ WF +PL G YP + + + R + Sbjct: 234 YPASDKPEDEAARRRAEAQMNRWFLDPLMGRG-YPEELTDVYGAAWR---------EFPK 283 Query: 809 AERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWG 868 + L+ D+ LN +T + E + R ++ Q + T V P Sbjct: 284 EDFELIAEPTDWMGLNWYTR--AVPENAPDAWPTRSRPVRQTQ---HAHTETGWEVYPPA 338 Query: 869 VRKLLRWV-RRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAY---LID 921 + L W+ + G + + +T +G D D R+ YLQ +KA + Sbjct: 339 LTDTLVWLSEQTGGKLPLMVTENGSAWYDPPHAIDGRIHDPMRVHYLQTHIKALHDAIGK 398 Query: 922 KVRIKGYYAFKLAEEKS-----KPRFG-----FFTSDFKAKSSIQFYNKVISSRG 966 V ++GY A+ L + RFG F T + K S Y +VI + G Sbjct: 399 GVDLRGYMAWSLLDNLEWSLGYSKRFGIVHVNFATQERTIKDSGLLYAEVIKTHG 453 >5NS7-A nrPDB Length = 454 Score = 199 bits (505), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 143/455 (31%), Positives = 219/455 (48%), Gaps = 56/455 (12%) Query: 85 FFWGIGTGALQVEGSWKKDGKGPSIWDHF--IHTHLKNVSSTNGSSDSYIFLEKDLSALD 142 F WG+ T + Q+EG+ + G+GPSIWD F I + N + + + D Y +DL + Sbjct: 23 FTWGVSTSSYQIEGAANQGGRGPSIWDTFSKIPGAVANGDNGDVACDHYHRYNEDLDLMK 82 Query: 143 FIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLAL 202 ++GV Y+FSI+WPR+ P G + N +G+ +Y L+D + R I P TLYHWDLP +L Sbjct: 83 WLGVGAYRFSIAWPRVIPSGYGAL-NKEGMDFYDRLIDGALERGITPWPTLYHWDLPQSL 141 Query: 203 QEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGN 262 Q+K GGW N F +Y+ + F DR+K WITI+ P+ AW G+ G+ APG K + Sbjct: 142 QDK-GGWNNRDCAYWFAEYSQKMAEAFSDRLKNWITINEPFCSAWLGHLYGVMAPGIK-D 199 Query: 263 LAAVYTVGHNLIKAH-----------SKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSE 311 L H+L+ H S++ +F P +ITLG E Sbjct: 200 LKTGINASHHLLLGHGLATKAIREVSSELKVGITLNFTP------AITLG---------E 244 Query: 312 NTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFA 371 ++ D + + WF +P+ YPE + K +PI + + D+ Sbjct: 245 SSEDKLAVELADGFDNRWFGDPVF-KAKYPEDIVKAFGKEVPIHP-GDMEIISTPLDYLG 302 Query: 372 FSFGPNNFKPLNTMAK----------------MGQNV-SLNLREALNWIKLEYNNPRILI 414 ++ + AK MG V + + E L + EY I I Sbjct: 303 LNYYFRQTVEYDATAKPLPYKQVTAPNVERTGMGWEVHAQSFTELLERVSKEYKPKEIFI 362 Query: 415 AENGWFTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 ENG D V K +D + ++ L + A + + + GY AWSL+D FEW Sbjct: 363 TENGSAWDDEVVDGKVDDPNRVSYLERHLDAMFAA-KNKGVPISGYFAWSLIDNFEWAYG 421 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 Y R G+ YVD+ +++ R PKSSA+YY++ I+E+ Sbjct: 422 YAKRFGIIYVDYQTQK--RIPKSSAYYYQKRIKES 454 Score = 99.0 bits (245), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 116/474 (24%), Positives = 198/474 (41%), Gaps = 81/474 (17%) Query: 525 FSWGVTESVLKPESVAS----SPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 F+WGV+ S + E A+ P D + A N C + Sbjct: 23 FTWGVSTSSYQIEGAANQGGRGPSIWDTFSKIPGAVANG----------DNGDVACDHYH 72 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 + L+++ + V YRF++ W V+P+G A+N++ + +Y ++ L+ GI+ T Sbjct: 73 RYNEDLDLMKWLGVGAYRFSIAWPRVIPSG-YGALNKEGMDFYDRLIDGALERGITPWPT 131 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP---NRL 697 LY H LP+ L GW N A F Y+ + D +K WITINEP L Sbjct: 132 LY-----HWDLPQSLQDKGGWNNRDCAYWFAEYSQKMAEAFSDRLKNWITINEPFCSAWL 186 Query: 698 SDIYN------RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 +Y + A+H+LL+ H LA + R+ + ++L+ PA Sbjct: 187 GHLYGVMAPGIKDLKTGINASHHLLLGHGLATKAI-REVSSELKVGITLNF-----TPAI 240 Query: 752 PYADSHWR--AAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 +S A E F+ WF +P+FK YP + + + +P + Sbjct: 241 TLGESSEDKLAVELADGFDNRWFGDPVFKA-KYPEDIVKAFGKE---------VP-IHPG 289 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSP-TRLAVIPWG 868 + ++ +D+ LN++ + V ++ A + + + Q +++P + W Sbjct: 290 DMEIISTPLDYLGLNYYFRQTVEYDATA-------KPLPYKQ----VTAPNVERTGMGWE 338 Query: 869 VR-----KLLRWVRRNYGDMDIYITASGI--DDQALE---DDRLRKYYLGKYLQEVLKAY 918 V +LL V + Y +I+IT +G DD+ ++ DD R YL ++L + A Sbjct: 339 VHAQSFTELLERVSKEYKPKEIFITENGSAWDDEVVDGKVDDPNRVSYLERHLDAMFAA- 397 Query: 919 LIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVI 962 V I GY+A+ L + RFG D++ KSS +Y K I Sbjct: 398 KNKGVPISGYFAWSLIDNFEWAYGYAKRFGIIYVDYQTQKRIPKSSAYYYQKRI 451 >5WKA-A nrPDB Length = 473 Score = 193 bits (491), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 154/486 (31%), Positives = 222/486 (45%), Gaps = 63/486 (12%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FP F WG T A Q+EG+ +DG+ PSIWD F T K V+ G + D Y E+DL Sbjct: 2 FPDGFVWGTSTAAYQIEGAVAEDGRTPSIWDTFSRTKGKVVNGDTGDVACDHYHRWEEDL 61 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +GV Y+FS++WPR+ PD + AN KGL +Y L+D L RNI P+ T+YHWDL Sbjct: 62 DLLAELGVQAYRFSVAWPRIHPD-VTGPANQKGLDFYQRLIDGLRDRNIIPLPTMYHWDL 120 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P AL+++ GGW F DYA + D + W T + P+ AW GYG G HAPG Sbjct: 121 PQALEDE-GGWIVRDTALRFADYAATVLEKL-DGIDKWTTFNEPWTSAWLGYGYGHHAPG 178 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 AA H L+ V RPH + L++ LG + P +E+ D+ Sbjct: 179 RTDIGAAAAATHHLLLAHGLGV--QAARAIRPHVEIGLTLNLGV--LRPGTTED-QDVEA 233 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMR---GTADFFAFSF- 374 ++ + + +P+ G+YP M + P F + ++ DF +F Sbjct: 234 TWRADGNQNRIWLDPLF-KGEYPADMIEHYSRWTPGFHTVQNGDLEIISSPIDFLGVNFY 292 Query: 375 GPNNF----------------------------------KPLNTMAKMGQNVSLN-LREA 399 GP P MG V LRE Sbjct: 293 GPGTVMNVGREDAARAAGFNVGPRPESDEDNHLRCIGVETPGRPKTAMGWEVDATALREL 352 Query: 400 LNWIKLEYNNPRILIAENGW----FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 L IK EY + + I ENG + ++ +D I + + L L AI D + + Sbjct: 353 LVRIKNEYTDIPLYITENGAAYHDYVNASGDVKDPERITYLNDHLEACLGAID-DGVNLQ 411 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTP 515 GY WSLLD FEW Y+ R G+ ++D+++ + R PK+S +Y+ ++ NG P Sbjct: 412 GYFIWSLLDNFEWGFGYSRRFGIVWIDYDTGR--RIPKASYRWYQGVVATNGL------P 463 Query: 516 DVQGQF 521 D+ G Sbjct: 464 DLDGHL 469 Score = 90.1 bits (222), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 122/489 (24%), Positives = 205/489 (41%), Gaps = 68/489 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F WG + + + E + + +W+ T +R +V V T C + Sbjct: 2 FPDGFVWGTSTAAYQIEGAVAEDGRTPS---IWD-TFSRTKGKV--VNGDTGDVACDHYH 55 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ L++LA + V YRF++ W + P A N++ L +Y+ ++ G+ Sbjct: 56 RWEEDLDLLAELGVQAYRFSVAWPRIHPDVTGPA-NQKGLDFYQRLID-----GLRDRNI 109 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 + PT H LP+ L GW+ TA F YA ++L D + W T NEP + + Sbjct: 110 IPLPTMYHWDLPQALEDEGGWIVRDTALRFADYAATVLEKL-DGIDKWTTFNEPWTSAWL 168 Query: 701 -----YNRSGNDTYGAAHNLLVAHALAWRL---YDRQFRPSQRGAVSLSLHADWAEPA-- 750 ++ G GAA LA L R RP + L+L+ P Sbjct: 169 GYGYGHHAPGRTDIGAAAAATHHLLLAHGLGVQAARAIRPHVE--IGLTLNLGVLRPGTT 226 Query: 751 -NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + ++ WRA Q I + +PLFK G+YPA M E+ S+ G + + Sbjct: 227 EDQDVEATWRADGN--QNRI--WLDPLFK-GEYPADMIEHY-SRWTPGFHT-----VQNG 275 Query: 810 ERRLLKGTVDFCALNHFTTRFVMH---EQLA-------GSRYDSDRDIQF----LQDITR 855 + ++ +DF +N + VM+ E A G R +SD D ++ R Sbjct: 276 DLEIISSPIDFLGVNFYGPGTVMNVGREDAARAAGFNVGPRPESDEDNHLRCIGVETPGR 335 Query: 856 LSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGK 909 + V +R+LL ++ Y D+ +YIT +G ++ D R YL Sbjct: 336 PKTAMGWEVDATALRELLVRIKNEYTDIPLYITENGAAYHDYVNASGDVKDPERITYLND 395 Query: 910 YLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYN 959 +L+ L A + D V ++GY+ + L + RFG D+ K+S ++Y Sbjct: 396 HLEACLGA-IDDGVNLQGYFIWSLLDNFEWGFGYSRRFGIVWIDYDTGRRIPKASYRWYQ 454 Query: 960 KVISSRGFP 968 V+++ G P Sbjct: 455 GVVATNGLP 463 >2Z1S-A nrPDB Length = 454 Score = 193 bits (491), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 133/453 (29%), Positives = 217/453 (47%), Gaps = 37/453 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FP F WG T + Q+EG + G+ PSIWD F K + G + D + ++D+ Sbjct: 14 FPATFMWGTSTSSYQIEGGTDEGGRTPSIWDTFCQIPGKVIGGDCGDVACDHFHHFKEDV 73 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G Y+FS++WPR+ P + N +GL +Y LLD + L + P++TLYHWDL Sbjct: 74 QLMKQLGFLHYRFSVAWPRIMP--AAGIINEEGLLFYEHLLDEIELAGLIPMLTLYHWDL 131 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ++++ GGW I F YA+ FG+R+ +W TI+ PY + GYGTG HAPG Sbjct: 132 PQWIEDE-GGWTQRETIQHFKTYASVIMDRFGERINWWNTINEPYCASILGYGTGEHAPG 190 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + N +T H+++ H N H G + ITL ++ SE D+ Sbjct: 191 HE-NWREAFTAAHHILMCHGIA---SNLHKEKGLTGKIGITLNMEHVDA-ASERPEDVAA 245 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRK---KLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 + + WFA P+ +G YPE M + + L + ++ DF ++ Sbjct: 246 AIRRDGFINRWFAEPLF-NGKYPEDMVEWYGTYLNGLDFVQPGDMELIQQPGDFLGINYY 304 Query: 376 PNNFKPLNTMAKMGQNVSLNLREA---LNW-----------IKLEYNNPR---ILIAENG 418 + A + Q +++ E + W ++E + + ILI ENG Sbjct: 305 TRSIIRSTNDASLLQVEQVHMEEPVTDMGWEIHPESFYKLLTRIEKDFSKGLPILITENG 364 Query: 419 WFTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIR 475 + + EDT ++ L + I + ++ GY WS LD FEW Y+ R Sbjct: 365 AAMRDELVNGQIEDTGRQRYIEEHLKACHRFIE-EGGQLKGYFVWSFLDNFEWAWGYSKR 423 Query: 476 RGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 G+ ++++ + +ER PK SA ++KQ++ +NGF Sbjct: 424 FGIVHINYET--QERTPKQSALWFKQMMAKNGF 454 Score = 113 bits (282), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 113/475 (23%), Positives = 212/475 (44%), Gaps = 62/475 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F WG + S + E + +W+ T ++ +V G C F Sbjct: 14 FPATFMWGTSTSSYQIEGGTDEGGRTPS---IWD-TFCQIPGKVIGGDCGD--VACDHFH 67 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 + K+ ++++ ++ HYRF++ W ++P + +N + L +Y ++ E G+ M+T Sbjct: 68 HFKEDVQLMKQLGFLHYRFSVAWPRIMPAAGI--INEEGLLFYEHLLDEIELAGLIPMLT 125 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ + GW T + F+ YA + G+ + W TINEP S + Sbjct: 126 LY-----HWDLPQWIEDEGGWTQRETIQHFKTYASVIMDRFGERINWWNTINEPYCASIL 180 Query: 701 YNRSGN---------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 +G + + AAH++L+ H +A L+ + G + ++L+ + + A+ Sbjct: 181 GYGTGEHAPGHENWREAFTAAHHILMCHGIASNLHKEK---GLTGKIGITLNMEHVDAAS 237 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 + AA R F WFAEPLF G YP M E+ G + L + + Sbjct: 238 ERPEDV-AAAIRRDGFINRWFAEPLF-NGKYPEDMVEWY------GTYLNGLDFVQPGDM 289 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLA--VIPWGV 869 L++ DF +N++T + R +D + ++ + T + + P Sbjct: 290 ELIQQPGDFLGINYYTRSII--------RSTNDASLLQVEQVHMEEPVTDMGWEIHPESF 341 Query: 870 RKLLRWVRRNYGD-MDIYITASG--IDDQALEDDRLRKYYLGKYLQEVLKA---YLIDKV 923 KLL + +++ + I IT +G + D+ L + ++ +Y++E LKA ++ + Sbjct: 342 YKLLTRIEKDFSKGLPILITENGAAMRDE-LVNGQIEDTGRQRYIEEHLKACHRFIEEGG 400 Query: 924 RIKGYYA------FKLAEEKSKPRFG-----FFTSDFKAKSSIQFYNKVISSRGF 967 ++KGY+ F+ A SK RFG + T + K S ++ ++++ GF Sbjct: 401 QLKGYFVWSFLDNFEWAWGYSK-RFGIVHINYETQERTPKQSALWFKQMMAKNGF 454 >3ZJK-A nrPDB Length = 431 Score = 192 bits (488), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 140/442 (31%), Positives = 217/442 (49%), Gaps = 42/442 (9%) Query: 83 KNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKDLSA 140 + F WG+ T A Q+EG+ ++DG+GPSIWD F +++ S+ + D Y E+D++ Sbjct: 6 EKFLWGVATSAYQIEGATQEDGRGPSIWDAFAQRPGAIRDGSTGEPACDHYRRYEEDIAL 65 Query: 141 LDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPL 200 + +GV Y+FS++WPR+ P+G + N KGL +Y L+D L+ I P +TLYHWDLPL Sbjct: 66 MQSLGVRAYRFSVAWPRILPEGRGRI-NPKGLAFYDRLVDRLLASGITPFLTLYHWDLPL 124 Query: 201 ALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEK 260 AL+E+ GGW++ F +YA + DRV ++ T++ P+ A+ G+ TG HAPG + Sbjct: 125 ALEER-GGWRSRETAFAFAEYAEAVARALADRVPFFATLNEPWCSAFLGHWTGEHAPGLR 183 Query: 261 GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQ 320 NL A H+L+ H ++ + + + E + + D + + Sbjct: 184 -NLEAALRAAHHLLLGHGLAVEALRAAG--ARRVGIVLNFAPAYGEDPEAVDVADRYHNR 240 Query: 321 QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSE-----AEKHEMRGTADFFAFSFG 375 +F +PI G G YPE + V PI S A + G + Sbjct: 241 --------FFLDPILGKG-YPESPFRDPPPV-PILSRDLELVARPLDFLGVNYYAPVRVA 290 Query: 376 PNN-------FKPLNTMAKMGQNV-SLNLREALNWIKLEYNNPRILIAENG------WFT 421 P P MG V L L + E P + + ENG W Sbjct: 291 PGTGTLPVRYLPPEGPATAMGWEVYPEGLHHLLKRLGREVPWP-LYVTENGAAYPDLWTG 349 Query: 422 DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYV 481 ++ V ED + ++ + L+A R + + + GY WSL+D FEW YT R GL+YV Sbjct: 350 EAVV--EDPERVAYLEAHVEAALRA-REEGVDLRGYFVWSLMDNFEWAFGYTRRSGLYYV 406 Query: 482 DFNSKQKERKPKSSAHYYKQII 503 DF S++ R PK SA +Y++ I Sbjct: 407 DFPSQR--RIPKRSALWYRERI 426 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 112/452 (24%), Positives = 183/452 (40%), Gaps = 66/452 (14%) Query: 525 FSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKK 584 F WGV S + E A+ P +W+A R +G T C + ++ Sbjct: 8 FLWGVATSAYQIEG-ATQEDGRGPS--IWDAFAQRPGAIRDG---STGEPACDHYRRYEE 61 Query: 585 QLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYP 644 + ++ + V YRF++ W +LP G +N + L +Y +V L GI+ +TLY Sbjct: 62 DIALMQSLGVRAYRFSVAWPRILPEGR-GRINPKGLAFYDRLVDRLLASGITPFLTLY-- 118 Query: 645 THAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRS 704 H LP L GW + TA AF YA + L D V + T+NEP + + + + Sbjct: 119 ---HWDLPLALEERGGWRSRETAFAFAEYAEAVARALADRVPFFATLNEPWCSAFLGHWT 175 Query: 705 GNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYA- 754 G G AAH+LL+ H LA + + ++R + L+ + E +P A Sbjct: 176 GEHAPGLRNLEAALRAAHHLLLGHGLA--VEALRAAGARRVGIVLNFAPAYGE--DPEAV 231 Query: 755 DSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLL 814 D R RF F +P+ G Y S R L R E L+ Sbjct: 232 DVADRYHNRF-------FLDPILGKG--------YPESPFRDPPPVPILSRDLE----LV 272 Query: 815 KGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLR 874 +DF +N++ V G+ R + T + V P G+ LL+ Sbjct: 273 ARPLDFLGVNYYAPVRVA----PGTGTLPVRYLPPEGPATAMG----WEVYPEGLHHLLK 324 Query: 875 WVRRNYGDMDIYITASGI------DDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGY 928 + R +Y+T +G +A+ +D R YL +++ L+A + V ++GY Sbjct: 325 RLGREV-PWPLYVTENGAAYPDLWTGEAVVEDPERVAYLEAHVEAALRARE-EGVDLRGY 382 Query: 929 YAFKLAEE-----KSKPRFGFFTSDFKAKSSI 955 + + L + R G + DF ++ I Sbjct: 383 FVWSLMDNFEWAFGYTRRSGLYYVDFPSQRRI 414 >5DT5-A nrPDB Length = 471 Score = 192 bits (488), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 141/460 (30%), Positives = 215/460 (46%), Gaps = 40/460 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 F NF +G T + Q+EG+ + G+ PSIWD F T K NG + D Y E+D+ Sbjct: 26 FAPNFVFGTATSSYQIEGAHDEGGRTPSIWDTFCDTDGKVFEKHNGDVACDHYHRFEEDI 85 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +GV Y+FSI+WPR+FP N +G+ +Y TL L I+P VTLYHWDL Sbjct: 86 QHIKQLGVDTYRFSIAWPRIFPSK--GQFNPEGMAFYKTLATRLQEEGIKPAVTLYHWDL 143 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P+ E+ GGW N +D F D+A CF+ V WIT + P+ + Y G HAPG Sbjct: 144 PMWAHEE-GGWVNRDSVDWFLDFARVCFEELDGIVDSWITHNEPWCAGFLSYHLGQHAPG 202 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 AV V H+++ +H K F +++ L + ++++ D Sbjct: 203 HTDMNEAVRAV-HHMLLSHGKAVEMLKGEFNSATPIGITLNLAPKYA---KTDSINDQIA 258 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRK---KLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 + WF +PI G YP M K + + DFF +F Sbjct: 259 MNNADGYANRWFLDPIF-KGQYPVDMMNLFSKYVHTYDFIHAGDLATISTPCDFFGINFY 317 Query: 376 PNNFKPLNTMAK--------------MGQNVSLN-LREALNWIKLEYNNPRILIAENGWF 420 N + + MG +++ + ++ + ++ EY + I I ENG Sbjct: 318 SRNLVEFSAASDFLHKDAYSDYDKTGMGWDIAPSEFKDLIRRLRAEYTDLPIYITENGAA 377 Query: 421 TDSRV---KTEDTTAIYMMKNFLSQVLQAIRL--DE-IRVFGYTAWSLLDGFEWQDAYTI 474 D ++ K D I ++++Q LQA+ DE + + GY WSLLD FEW Y Sbjct: 378 FDDQLVDGKIHDQNRI----DYVAQHLQAVSDLNDEGMNIAGYYLWSLLDNFEWSFGYDK 433 Query: 475 RRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKEST 514 R G+ YVDF++ +ER K SAH+Y +I+ + +L + Sbjct: 434 RFGIIYVDFDT--QERIWKDSAHWYANVIQTHKAALPQEA 471 Score = 102 bits (253), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 104/415 (25%), Positives = 179/415 (43%), Gaps = 51/415 (12%) Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 C + ++ ++ + ++ V YRF++ W + P+ N + + +Y+ + + + GI Sbjct: 75 CDHYHRFEEDIQHIKQLGVDTYRFSIAWPRIFPSK--GQFNPEGMAFYKTLATRLQEEGI 132 Query: 636 SAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 VTLY H LP GW+N + + F +A +CF+EL +V WIT NEP Sbjct: 133 KPAVTLY-----HWDLPMWAHEEGGWVNRDSVDWFLDFARVCFEELDGIVDSWITHNEPW 187 Query: 696 RLSDIYNRSG---------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADW 746 + G N+ A H++L++H A + +F + ++L+L + Sbjct: 188 CAGFLSYHLGQHAPGHTDMNEAVRAVHHMLLSHGKAVEMLKGEFNSATPIGITLNLAPKY 247 Query: 747 AEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRL 806 A+ + A+ + WF +P+FK G YP M + SK+ + Sbjct: 248 AKTDSINDQIAMNNADGYAN---RWFLDPIFK-GQYPVDMMN-LFSKYVH-----TYDFI 297 Query: 807 TEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIP 866 + + DF +N ++ V E A S + +D D T + + P Sbjct: 298 HAGDLATISTPCDFFGINFYSRNLV--EFSAASDF-LHKDAYSDYDKTGMG----WDIAP 350 Query: 867 WGVRKLLRWVRRNYGDMDIYITASG--IDDQALE---DDRLRKYYLGKYLQEVLKAYLID 921 + L+R +R Y D+ IYIT +G DDQ ++ D+ R Y+ ++LQ V + L D Sbjct: 351 SEFKDLIRRLRAEYTDLPIYITENGAAFDDQLVDGKIHDQNRIDYVAQHLQAV--SDLND 408 Query: 922 K-VRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSR 965 + + I GYY + L + RFG DF K S +Y VI + Sbjct: 409 EGMNIAGYYLWSLLDNFEWSFGYDKRFGIIYVDFDTQERIWKDSAHWYANVIQTH 463 >1GNX-A nrPDB Length = 479 Score = 190 bits (483), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 144/473 (30%), Positives = 218/473 (46%), Gaps = 65/473 (13%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT--HLKNVSSTNGSSDSYIFLEKD 137 TFP+ F WG T + Q+EG+ +DG+ PSIWD + T ++N + + ++D Y +D Sbjct: 17 TFPEGFLWGSATASYQIEGAAAEDGRTPSIWDTYARTPGRVRNGDTGDVATDHYHRWRED 76 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + +G+ Y+FS++WPR+ P G A KGL +Y L D L+ + I+P+ TLYHWD Sbjct: 77 VALMAELGLGAYRFSLAWPRIQPTG-RGPALQKGLDFYRRLADELLAKGIQPVATLYHWD 135 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP L E GGW + F +YA GDRVK W T++ P+ A+ GYG+G+HAP Sbjct: 136 LPQEL-ENAGGWPERATAERFAEYAAIAADALGDRVKTWTTLNEPWCSAFLGYGSGVHAP 194 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEP-NRSENTMDI 316 G +AA+ H+L H + S+TL H + P S+ D Sbjct: 195 GRTDPVAAL-RAAHHLNLGHGLAVQALRDRLPADAQ--CSVTLNIHHVRPLTDSDADADA 251 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVL------------------------ 352 + ++ + + F P+ G YPE + K + Sbjct: 252 VRRIDALANRV--FTGPML-QGAYPEDLVKDTAGLTDWSFVRDGDLRLAHQKLDFLGVNY 308 Query: 353 ---PIFSEAE-------------KHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLN- 395 + SEA+ H AD AF +P MG V + Sbjct: 309 YSPTLVSEADGSGTHNSDGHGRSAHSPWPGADRVAF------HQPPGETTAMGWAVDPSG 362 Query: 396 LREALNWIKLEYNNPRILIAENGW----FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDE 451 L E L + ++ ++I ENG + D D I +++ L+ V +AI+ D Sbjct: 363 LYELLRRLSSDFPALPLVITENGAAFHDYADPEGNVNDPERIAYVRDHLAAVHRAIK-DG 421 Query: 452 IRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504 V GY WSLLD FEW Y+ R G YVD+ + R PK+SA +Y ++ R Sbjct: 422 SDVRGYFLWSLLDNFEWAHGYSKRFGAVYVDYPTGT--RIPKASARWYAEVAR 472 Score = 100 bits (249), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 129/496 (26%), Positives = 209/496 (42%), Gaps = 68/496 (13%) Query: 513 STPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTR 572 + PD FP F WG + + E A+ + +W+ T R RV T Sbjct: 10 TAPDAALTFPEGFLWGSATASYQIEGAAAEDGRTP---SIWD-TYARTPGRVRNG--DTG 63 Query: 573 PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 + ++ + ++A + + YRF+L W + PTG A+ ++ L +YR + E L Sbjct: 64 DVATDHYHRWREDVALMAELGLGAYRFSLAWPRIQPTGRGPAL-QKGLDFYRRLADELLA 122 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI + TLY H LP+ L +A GW +TAE F YA + LGD VK W T+N Sbjct: 123 KGIQPVATLY-----HWDLPQELENAGGWPERATAERFAEYAAIAADALGDRVKTWTTLN 177 Query: 693 EPNRLSDIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLH 743 EP + + SG G AAH+L + H LA + + + +V+L++H Sbjct: 178 EPWCSAFLGYGSGVHAPGRTDPVAALRAAHHLNLGHGLAVQALRDRLPADAQCSVTLNIH 237 Query: 744 ADWAEPANPYADS--HWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSS 801 P DS A R F P+ + G YP + K GL+ Sbjct: 238 H-----VRPLTDSDADADAVRRIDALANRVFTGPMLQ-GAYPEDL-----VKDTAGLTDW 286 Query: 802 ALPRLTEAERRLLKGTVDFCALNHFTTRFVM------------HEQLAGSRYDSDRDIQF 849 + R + + RL +DF +N+++ V H + A S + + F Sbjct: 287 SFVR--DGDLRLAHQKLDFLGVNYYSPTLVSEADGSGTHNSDGHGRSAHSPWPGADRVAF 344 Query: 850 LQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLR 903 Q ++ AV P G+ +LLR + ++ + + IT +G D + +D R Sbjct: 345 HQPPGETTA-MGWAVDPSGLYELLRRLSSDFPALPLVITENGAAFHDYADPEGNVNDPER 403 Query: 904 KYYLGKYLQEVLKAYLIDKVRIKGYY------AFKLAEEKSKPRFGFFTSDFKA-----K 952 Y+ +L V +A + D ++GY+ F+ A SK RFG D+ K Sbjct: 404 IAYVRDHLAAVHRA-IKDGSDVRGYFLWSLLDNFEWAHGYSK-RFGAVYVDYPTGTRIPK 461 Query: 953 SSIQFYNKVISSRGFP 968 +S ++Y +V + P Sbjct: 462 ASARWYAEVARTGVLP 477 >5YHS-A nrPDB Length = 475 Score = 189 bits (480), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 140/477 (29%), Positives = 223/477 (46%), Gaps = 57/477 (11%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 FP +F +G + + QVEG+W +DGKG + WD F K + TNG + D Y ++D+ Sbjct: 3 FPHDFLFGAASASYQVEGAWNEDGKGVTNWDEFSKIPGKTYNGTNGDIAVDHYHRYKEDV 62 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FSISW R+ P G V N KG+++Y+ L+D + I P VTLYHWDL Sbjct: 63 RLMAEMGLESYRFSISWARILPTGDGKV-NEKGIEFYNNLIDECLKYGIVPFVTLYHWDL 121 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 PL L EK GGW N + F YA CF+ FGDRVK+WIT + + GY G H PG Sbjct: 122 PLPL-EKDGGWTNKRTAEAFVKYAETCFKAFGDRVKHWITFNETVMFCGLGYLKGAHPPG 180 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + ++ + H + AH+K Y + + G + L ++ ++ + +I Sbjct: 181 IQNDVPKYFQATHYVFYAHAKTVAVYKQLKQYGEIGITHVFLPAYSVDDQKE----NIQA 236 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV--LPIFSEAEKHEMRGTADFFAFSFGP 376 + W+ +PI G+YP + ++L P ++ E ++ A+ F G Sbjct: 237 ANHANEYETYWYYDPIL-KGEYPSYVVQQLKEKGWTPNWTVEELEIIKQNAEENDF-IGL 294 Query: 377 NNFKPL---------------------------------------NTMAKMGQNVS-LNL 396 N ++P+ T K G +S Sbjct: 295 NYYQPIRVERYDMDIKSEEHSRENSTLAPGNPSFDGFYRTVKMDDKTYTKWGWEISPEGF 354 Query: 397 REALNWIKLEYNNPRILIAENGWFTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIR 453 E L+ +K Y + ++ + ENG + + + D I ++ L + +AI + I Sbjct: 355 LEGLHMLKARYGDIKMYVTENGLGDEDPIIDGEIVDVPRIKFIEAHLKVMKRAIE-EGIN 413 Query: 454 VFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 + GY AWS++D W + Y + G +VD N K RK K S H+YK+++ G L Sbjct: 414 LKGYYAWSVIDLLSWLNGYKKQYGFIFVDHNDNLK-RKKKLSFHWYKRVVETRGEEL 469 Score = 140 bits (352), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 128/498 (25%), Positives = 214/498 (42%), Gaps = 84/498 (16%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD- 578 +FP DF +G + + E WN G + + E ++ + T+ Sbjct: 2 KFPHDFLFGAASASYQVEGA-------------WNEDGKGVTNWDEFSKIPGKTYNGTNG 48 Query: 579 ------FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 + K+ + ++A M + YRF++ WA +LPTG+ VN + + +Y ++ E LK Sbjct: 49 DIAVDHYHRYKEDVRLMAEMGLESYRFSISWARILPTGD-GKVNEKGIEFYNNLIDECLK 107 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI VTLY H LP PL GW N TAEAF YA CF+ GD VK WIT N Sbjct: 108 YGIVPFVTLY-----HWDLPLPLEKDGGWTNKRTAEAFVKYAETCFKAFGDRVKHWITFN 162 Query: 693 EPNRLSDIYNRSG-------NDT---YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSL 742 E + G ND + A H + AHA +Y + + + G + L Sbjct: 163 ETVMFCGLGYLKGAHPPGIQNDVPKYFQATHYVFYAHAKTVAVYKQLKQYGEIGITHVFL 222 Query: 743 HADWAEPANPYAD--SHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSS 800 PA D + +AA ++E W+ +P+ K G+YP+ + + + K Sbjct: 223 ------PAYSVDDQKENIQAANHANEYETYWYYDPILK-GEYPSYVVQQLKEK------- 268 Query: 801 SALPRLTEAERRLLKGTV---DFCALNHF----TTRFVM------HEQLAGSRYDSDRDI 847 P T E ++K DF LN++ R+ M H + + + Sbjct: 269 GWTPNWTVEELEIIKQNAEENDFIGLNYYQPIRVERYDMDIKSEEHSRENSTLAPGNPSF 328 Query: 848 QFLQDITRLSSPTRL----AVIPWGVRKLLRWVRRNYGDMDIYITASGI-DDQALEDDRL 902 ++ T + P G + L ++ YGD+ +Y+T +G+ D+ + D + Sbjct: 329 DGFYRTVKMDDKTYTKWGWEISPEGFLEGLHMLKARYGDIKMYVTENGLGDEDPIIDGEI 388 Query: 903 RKYYLGKYLQ---EVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF----- 949 K+++ +V+K + + + +KGYYA+ + + S K ++GF D Sbjct: 389 VDVPRIKFIEAHLKVMKRAIEEGINLKGYYAWSVIDLLSWLNGYKKQYGFIFVDHNDNLK 448 Query: 950 -KAKSSIQFYNKVISSRG 966 K K S +Y +V+ +RG Sbjct: 449 RKKKLSFHWYKRVVETRG 466 >5AYI-A nrPDB Length = 457 Score = 189 bits (479), Expect = 8e-48, Method: Compositional matrix adjust. Identities = 138/448 (30%), Positives = 215/448 (47%), Gaps = 34/448 (7%) Query: 79 DTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEK 136 + FP +F WG T A Q+EG+ ++DG+G SIWD F HT K T G + DSY + Sbjct: 4 ERFPADFVWGAATAAYQIEGAVREDGRGVSIWDTFSHTPGKIADGTTGDVACDSYHRYGE 63 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 D+ L+ +G++ Y+FSI+WPR+ P G + N GL +YS ++DAL+ ++P VTLYHW Sbjct: 64 DIGLLNALGMNAYRFSIAWPRIVPLGAGPI-NQAGLDHYSRMVDALLGAGLQPFVTLYHW 122 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP L+++ GW + +F +YA + GDRV +W T++ P+ A GY G+HA Sbjct: 123 DLPQPLEDRL-GWGSRATATVFAEYADIVVRQLGDRVTHWATLNEPWCSAMLGYYLGVHA 181 Query: 257 PGEKGNLAAVYTVGHNLIKAHS-KVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMD 315 PG +L HNL+ H V +P Q G I L P S++ D Sbjct: 182 PGHT-DLKRGLEASHNLLLGHGLAVQAMRAAAPQPLQIG---IVLQLTPTYPA-SDSPED 236 Query: 316 IFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 + ++ V WF +P+ G G YP+ M + P + + ++ D+ ++ Sbjct: 237 VAAARRFDGFVNRWFLDPLAGRG-YPQDMLDYYGAAAPQANPEDLTQIAAPLDWLGVNYY 295 Query: 376 PNNFKPLNTMAKMGQNVSLN------------LREALNWIKLEYNNP----RILIAENGW 419 A + Q L+ E L I L +N + I ENG Sbjct: 296 ERMRAVDAPDASLPQAQRLDDPDLPHTADREVYPEGLYDILLRLHNDYPFRPLYITENGC 355 Query: 420 FTDSRVKTE----DTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIR 475 + + D + L+Q+ +A+ + + GY AWSLLD FEW ++R Sbjct: 356 ALHDEIAEDGGIHDGQRQAFFEAHLAQLQRALAAG-VPLKGYFAWSLLDNFEWAMGLSMR 414 Query: 476 RGLFYVDFNSKQKERKPKSSAHYYKQII 503 G+ Y +F + ER+ K S ++ + I Sbjct: 415 YGICYTNFET--LERRIKDSGYWLRDFI 440 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 116/432 (26%), Positives = 184/432 (42%), Gaps = 53/432 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP DF WG + + E + +W+ + +G T C + Sbjct: 5 RFPADFVWGAATAAYQIEGAVREDGRG---VSIWDTFSHTPGKIADGT---TGDVACDSY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 + + +L + + YRF++ W ++P G +N+ L +Y +V L G+ V Sbjct: 59 HRYGEDIGLLNALGMNAYRFSIAWPRIVPLGA-GPINQAGLDHYSRMVDALLGAGLQPFV 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+PL GW + +TA F YA + ++LGD V W T+NEP + Sbjct: 118 TLY-----HWDLPQPLEDRLGWGSRATATVFAEYADIVVRQLGDRVTHWATLNEPWCSAM 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWR-LYDRQFRPSQRGAVSLSLHADWAEP 749 + G G A+HNLL+ H LA + + +P Q G V L L P Sbjct: 173 LGYYLGVHAPGHTDLKRGLEASHNLLLGHGLAVQAMRAAAPQPLQIGIV-LQL-----TP 226 Query: 750 ANPYADS--HWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT 807 P +DS AA RF F WF +PL G YP M +Y +A P+ Sbjct: 227 TYPASDSPEDVAAARRFDGFVNRWFLDPLAGRG-YPQDMLDYY---------GAAAPQAN 276 Query: 808 EAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPW 867 + + +D+ +N++ + A S Q L D + R V P Sbjct: 277 PEDLTQIAAPLDWLGVNYYERMRAVDAPDA-----SLPQAQRLDDPDLPHTADR-EVYPE 330 Query: 868 GVRKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLID 921 G+ +L + +Y +YIT +G + D+ ED D R+ + +L ++ +A L Sbjct: 331 GLYDILLRLHNDYPFRPLYITENGCALHDEIAEDGGIHDGQRQAFFEAHLAQLQRA-LAA 389 Query: 922 KVRIKGYYAFKL 933 V +KGY+A+ L Sbjct: 390 GVPLKGYFAWSL 401 >4HZ6-A nrPDB Length = 444 Score = 188 bits (478), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 136/452 (30%), Positives = 210/452 (46%), Gaps = 36/452 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF--IHTHLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG T + Q+EG+W +DGKG SIWD F I +KN S + + D Y E+DL Sbjct: 5 FPEGFLWGAATSSYQIEGAWNEDGKGESIWDRFTRIPGKIKNGDSGDVACDHYHRYEQDL 64 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FSI+W R+ PD + N +GL +Y L++ L R+I P+ TLYHWDL Sbjct: 65 DLMRQLGLKTYRFSIAWARIQPDSSRQI-NQRGLDFYRRLVEGLHKRDILPMATLYHWDL 123 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ++++ GGW + F +Y GD++ W+T + P + W GY G+ APG Sbjct: 124 PQWVEDE-GGWLSRESASRFAEYTHALVAALGDQIPLWVTHNEPMVTVWAGYHMGLFAPG 182 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K V H+L+ +H + + + + ITL + I P +E D+ Sbjct: 183 LKDPTLGG-RVAHHLLLSHGQALQAFRALSPAGSQ--MGITLNFNTIYPVSAE-PADVEA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ F P+ G Y + ++ + + + DF G N Sbjct: 239 ARRMHSFQNELFLEPLI-RGQYNQATLMAYPNLPEFIAPEDMQTISAPIDF----LGVNY 293 Query: 379 FKPL-----------------NTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENG-W 419 + P+ + + MG ++ L + L I Y I I ENG Sbjct: 294 YNPMRVKSSPQPPGIEVVQVESPVTAMGWEIAPEGLYDLLMGITRTYGKLPIYITENGAA 353 Query: 420 FTDSRVKTEDTTAIYMMKNFLSQVLQAIR--LDEIRVFGYTAWSLLDGFEWQDAYTIRRG 477 F D ++ + F + A R D + + GY AWSLLD FEW + Y+ R G Sbjct: 354 FDDQPDQSGQVNDPQRVGYFQGHIGAARRALADGVDLRGYYAWSLLDNFEWAEGYSKRFG 413 Query: 478 LFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 + YVDF ++Q R K SA +Y+ +I NG Sbjct: 414 IIYVDFETQQ--RTLKQSAQWYRDVIANNGLE 443 Score = 115 bits (287), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 132/488 (27%), Positives = 204/488 (41%), Gaps = 89/488 (18%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWN--ATGNRLLHRVEGVRLKTRPAQ-- 575 +FP F WG S + E WN G + R + K + Sbjct: 4 KFPEGFLWGAATSSYQIEGA-------------WNEDGKGESIWDRFTRIPGKIKNGDSG 50 Query: 576 ---CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 C + ++ L+++ ++ + YRF++ WA + P + +N++ L +YR +V K Sbjct: 51 DVACDHYHRYEQDLDLMRQLGLKTYRFSIAWARIQPDSS-RQINQRGLDFYRRLVEGLHK 109 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 I M TLY H LP+ + GWL+ +A F Y LGD + LW+T N Sbjct: 110 RDILPMATLY-----HWDLPQWVEDEGGWLSRESASRFAEYTHALVAALGDQIPLWVTHN 164 Query: 693 EPN-------RLSDIYNRSGNDTYGA--AHNLLVAHALAWRLYDRQFRP--SQRGAVSLS 741 EP + + T G AH+LL++H A + + R P SQ G ++L+ Sbjct: 165 EPMVTVWAGYHMGLFAPGLKDPTLGGRVAHHLLLSHGQALQAF-RALSPAGSQMG-ITLN 222 Query: 742 LHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSS 801 + + A P AD AA R F+ F EPL + G Y A ++ Sbjct: 223 FNTIYPVSAEP-ADV--EAARRMHSFQNELFLEPLIR-GQYNQATL----------MAYP 268 Query: 802 ALPRLTEAE-RRLLKGTVDFCALNHFT-TRFVMHEQLAGSRYDSDRDIQFLQDITRLSSP 859 LP E + + +DF +N++ R Q G ++ ++ SP Sbjct: 269 NLPEFIAPEDMQTISAPIDFLGVNYYNPMRVKSSPQPPGI------------EVVQVESP 316 Query: 860 TRL---AVIPWGVRKLLRWVRRNYGDMDIYITASG--IDDQALE----DDRLRKYYLGKY 910 + P G+ LL + R YG + IYIT +G DDQ + +D R Y + Sbjct: 317 VTAMGWEIAPEGLYDLLMGITRTYGKLPIYITENGAAFDDQPDQSGQVNDPQRVGYFQGH 376 Query: 911 LQEVLKAYLIDKVRIKGYYA------FKLAEEKSKPRFGFFTSDFKA-----KSSIQFYN 959 + +A L D V ++GYYA F+ AE SK RFG DF+ K S Q+Y Sbjct: 377 IGAARRA-LADGVDLRGYYAWSLLDNFEWAEGYSK-RFGIIYVDFETQQRTLKQSAQWYR 434 Query: 960 KVISSRGF 967 VI++ G Sbjct: 435 DVIANNGL 442 >3W53-A nrPDB Length = 506 Score = 169 bits (427), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 140/471 (29%), Positives = 204/471 (43%), Gaps = 56/471 (11%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTN--GSSDSYIFLEKD 137 +PK F WG T A Q+EG+ GK S+WD F N + D Y +D Sbjct: 44 AWPKEFLWGSATAAAQIEGAGHSYGKEDSVWDAFARKEGAIAGGENLEVAVDHYHRYRED 103 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FS SW R+ P G N +GL +YS L+D L+ I P +TLYHWD Sbjct: 104 VQLMRELGLDSYRFSTSWARVVPGG--RTVNPEGLDFYSRLVDELLENGILPWLTLYHWD 161 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP AL+E+ GGW N F +YA + GDRVK+W T + P + GY G HAP Sbjct: 162 LPQALEER-GGWTNRETSYKFLEYAETVHEKLGDRVKHWTTFNEPLCSSLIGYAAGEHAP 220 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G + AA+ V H + AH R + ITL PN + +D+ Sbjct: 221 GRQEPQAALAAVHHQHL-AHGLA----TARLRELGAEHIGITLNLTNAVPNNPGDPVDLE 275 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKL--FSVLPIFSEAEKHEMRGTADFFAFSF- 374 ++ + +P+ G YPE + + + + + + + DF + Sbjct: 276 AARRVDALWNRMYLDPVL-RGSYPEDLLEDVQGLGLAEVIEAGDLEIISQPIDFLGVNHY 334 Query: 375 -------------GPNNFKPLNT--------------------MAKMGQNVS-LNLREAL 400 P P ++ MG V+ LR L Sbjct: 335 HDDNVSGHPLPAGQPQPVVPTDSPKSSPFVGSEYVTFPARDLPRTAMGWEVNPEGLRVLL 394 Query: 401 NWIKLEYNN-PRILIAENGW-FTDSRVK---TEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 N + +Y N P + I ENG +TD+ + ED + N L V++AI D + V Sbjct: 395 NRLNQDYANLPSLYITENGASYTDTVTEAGTVEDPEREEYILNHLDAVVRAI-ADGVDVR 453 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 GY WSLLD FEW Y R G+ +VD+ ++ R K+S Y +I N Sbjct: 454 GYFVWSLLDNFEWAWGYAKRFGIIHVDYQTQV--RTIKNSGKAYAGLIAAN 502 Score = 110 bits (274), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 123/486 (25%), Positives = 207/486 (42%), Gaps = 71/486 (14%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 +P +F WG + + E S D VW+A + G L+ + Sbjct: 45 WPKEFLWGSATAAAQIEGAGHSYGKEDS---VWDAFARKEGAIAGGENLEV---AVDHYH 98 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ ++++ + + YRF+ WA V+P G VN + L +Y +V E L+ GI +T Sbjct: 99 RYREDVQLMRELGLDSYRFSTSWARVVPGGR--TVNPEGLDFYSRLVDELLENGILPWLT 156 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GW N T+ F YA ++LGD VK W T NEP S I Sbjct: 157 LY-----HWDLPQALEERGGWTNRETSYKFLEYAETVHEKLGDRVKHWTTFNEPLCSSLI 211 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 +G G A H+ +AH LA + R + ++L+ A P N Sbjct: 212 GYAAGEHAPGRQEPQAALAAVHHQHLAHGLA----TARLRELGAEHIGITLNLTNAVPNN 267 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA-E 810 P AA R + +P+ + G YP + E + +GL L + EA + Sbjct: 268 PGDPVDLEAARRVDALWNRMYLDPVLR-GSYPEDLLEDV-----QGL---GLAEVIEAGD 318 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSR------YDSDRDIQFL---------QDITR 855 ++ +DF +NH+ V L + DS + F+ +D+ R Sbjct: 319 LEIISQPIDFLGVNHYHDDNVSGHPLPAGQPQPVVPTDSPKSSPFVGSEYVTFPARDLPR 378 Query: 856 LSSPTRLAVIPWGVRKLLRWVRRNYGDM-DIYITASG------IDDQALEDDRLRKYYLG 908 + V P G+R LL + ++Y ++ +YIT +G + + +D R+ Y+ Sbjct: 379 TA--MGWEVNPEGLRVLLNRLNQDYANLPSLYITENGASYTDTVTEAGTVEDPEREEYIL 436 Query: 909 KYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFY 958 +L V++A + D V ++GY+ + L + RFG D++ K+S + Y Sbjct: 437 NHLDAVVRA-IADGVDVRGYFVWSLLDNFEWAWGYAKRFGIIHVDYQTQVRTIKNSGKAY 495 Query: 959 NKVISS 964 +I++ Sbjct: 496 AGLIAA 501 >4IPN-B nrPDB Length = 487 Score = 153 bits (386), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 141/478 (29%), Positives = 212/478 (44%), Gaps = 60/478 (12%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSS-------DSYIF 133 FP +F WG A QVEG++ +DGKG S+ D L + D Y Sbjct: 20 FPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEATENPTEDNLKLIGIDFYHK 79 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTL 193 ++D+S +G + ++ SI+W R+FP G N GL+YY L D L IEP+VTL Sbjct: 80 YKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGLKYYDELFDELHAHGIEPLVTL 139 Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGT- 252 H++ PL L KY GW + +I + +A + + D+VKYW+T + V + + Sbjct: 140 SHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYKDKVKYWLTFNEVNSVLELPFTSG 199 Query: 253 GMHAPGEKGNLAAVYTVGHNLIKAHS---KVWHNYNTHFRPHQKGWLSITLGSHWIEPNR 309 G+ P E + +Y H+ + A S K+ N+ F+ G + + + ++ + PN Sbjct: 200 GIDIPKENLSKQELYQAIHHELVASSLVTKIAREINSEFK---VGCMVLAMPAYPMTPNP 256 Query: 310 SENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSE--AEKHEM--RG 365 D++ + L + + +H G YP K+ F I E AE E+ Sbjct: 257 K----DVWATHE--YENLNYLFSDVHVRGYYP-NYAKRYFKENDINIEFAAEDAELLKNY 309 Query: 366 TADFFAFSF---------------GPNNF-----KPLNTMAKMGQNVS-LNLREALNWIK 404 T DF +FS+ G N P ++ G + + LR LN Sbjct: 310 TVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESSEWGWQIDPIGLRIILNRYY 369 Query: 405 LEYNNPRILIAENGW-FTDSRVKTE-------DTTAIYMMKNFLSQVLQAIRLDEIRVFG 456 Y P + I ENG D +K E D I MK L QV +A++ D + + G Sbjct: 370 DRYQIP-LFIVENGLGAKDQLIKDELNNLTVQDDYRIQYMKEHLLQVAEALQ-DGVEIMG 427 Query: 457 YTAWSLLDGFEWQDAYTIRR-GLFYVDFN---SKQKERKPKSSAHYYKQIIRENGFSL 510 YT+W +D A +R GL YVD N S R K S +YK++I NG SL Sbjct: 428 YTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGSGTLNRYKKMSFTWYKEVIESNGESL 485 Score = 68.9 bits (167), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 112/494 (22%), Positives = 191/494 (38%), Gaps = 79/494 (15%) Query: 521 FPCDFSWG------VTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPA 574 FP DF WG E + S Q P + AT N ++ + + Sbjct: 20 FPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEATENPTEDNLKLIGI----- 74 Query: 575 QCTDFVN-IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKL 633 DF + K+ + + + M +R ++ W+ + P G+ N L+YY + E Sbjct: 75 ---DFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGLKYYDELFDELHAH 131 Query: 634 GISAMVTL-YYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI +VTL +Y T +L GW++ ++ +A + D VK W+T N Sbjct: 132 GIEPLVTLSHYETPLYLA-----RKYHGWVDRRMIHFYEKFARTVLERYKDKVKYWLTFN 186 Query: 693 EPNRLSDI-----------YNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLS 741 E N + ++ N S + Y A H+ LVA +L ++ + G + L+ Sbjct: 187 EVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREINSEFKVGCMVLA 246 Query: 742 LHADWAEPANPYADSHWRAAERFLQFE-IAWFAEPLFKTGDYPAAMREYIASKHRRGLSS 800 + A P P W E +E + + + G YP + Y + Sbjct: 247 MP---AYPMTPNPKDVWATHE----YENLNYLFSDVHVRGYYPNYAKRYFK-------EN 292 Query: 801 SALPRLTEAERRLLKG-TVDFCALNHFTTRFVMHEQLAGSRYDSDRD--IQFLQDITRLS 857 + LLK TVDF + +++ + + + ++Y+S I L + S Sbjct: 293 DINIEFAAEDAELLKNYTVDFLSFSYYMS---VTQSALPTQYNSGEGNIIGGLVNPYLES 349 Query: 858 SPTRLAVIPWGVRKLL-RWVRRNYGDMDIYITASGIDDQALED--------DRLRKYYLG 908 S + P G+R +L R+ R + I G DQ ++D D R Y+ Sbjct: 350 SEWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDELNNLTVQDDYRIQYMK 409 Query: 909 KYLQEVLKAYLIDKVRIKGYYAF------KLAEEKSKPRFGFFTSDFK----------AK 952 ++L +V +A L D V I GY ++ ++ + R+G D K Sbjct: 410 EHLLQVAEA-LQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGSGTLNRYKK 468 Query: 953 SSIQFYNKVISSRG 966 S +Y +VI S G Sbjct: 469 MSFTWYKEVIESNG 482 >4F66-A nrPDB Length = 480 Score = 151 bits (382), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 132/487 (27%), Positives = 217/487 (44%), Gaps = 76/487 (15%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI---HTHLKNVSS---------TNGSS 128 P+NF WG A Q+EG W++ GKG S+ D H + +++ + + Sbjct: 7 LPENFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITAGVLEGKYYPNHEAI 66 Query: 129 DSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIE 188 D Y ++D+ +G ++ SI+W R+FP G N GLQ+Y L D + IE Sbjct: 67 DFYHHYKEDVKLFAEMGFKCFRTSIAWTRIFPKGDEAEPNEAGLQFYDDLFDECLKYGIE 126 Query: 189 PIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN------- 241 P+VTL H++LP L +YGG+ N +ID F +A CF+ + D+VKYW+T + Sbjct: 127 PVVTLSHFELPYHLVTEYGGFTNRKVIDFFVHFAEVCFRRYKDKVKYWMTFNEINNQANY 186 Query: 242 -----PYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHS---KVWHNYNTHFRPHQK 293 P+ + Y G A +Y H + A + K+ H N + Sbjct: 187 QEDFAPFTNSGIVYKEG------DDREAIMYQAAHYELVASARAVKIGHAINPNLN---- 236 Query: 294 GWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRK--KLFSV 351 + + I P N DI Q++M +FA+ +H G YPE + K + ++ Sbjct: 237 --IGCMVAMCPIYPATC-NPKDILMAQKAMQKRY-YFAD-VHVHGFYPEHIFKYWERKAI 291 Query: 352 LPIFSEAEKHEM-RGTADFFAFSF----------GPNNFKPLNTMAKMGQNVSL------ 394 F+E +K ++ GT D+ FS+ N + + +N + Sbjct: 292 KVDFTERDKKDLFEGTVDYIGFSYYMSFVIDAHRENNPYYDYLETEDLVKNPYVKASDWD 351 Query: 395 ------NLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVL 444 LR ALNW Y+ P + I ENG+ +V+ + D I + + +++ Sbjct: 352 WQIDPQGLRYALNWFTDMYHLP-LFIVENGFGAIDQVEADGMVHDDYRIDYLGAHIKEMI 410 Query: 445 QAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRR-GLFYVDFNSKQK---ERKPKSSAHYYK 500 +A+ D + + GYT W +D +R G YVD + + K +R PK S ++YK Sbjct: 411 KAVDEDGVELMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDEGKGTLKRSPKLSFNWYK 470 Query: 501 QIIRENG 507 ++I NG Sbjct: 471 EVIASNG 477 Score = 96.7 bits (239), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 106/424 (25%), Positives = 181/424 (42%), Gaps = 59/424 (13%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 K+ +++ A M +R ++ W + P G+ + N L++Y + E LK GI +VTL Sbjct: 73 KEDVKLFAEMGFKCFRTSIAWTRIFPKGDEAEPNEAGLQFYDDLFDECLKYGIEPVVTL- 131 Query: 643 YPTHAHLGLPEPLL-HADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL---- 697 +H LP L+ G+ N + F +A +CF+ D VK W+T NE N Sbjct: 132 ----SHFELPYHLVTEYGGFTNRKVIDFFVHFAEVCFRRYKDKVKYWMTFNEINNQANYQ 187 Query: 698 --------SDIYNRSGND----TYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHAD 745 S I + G+D Y AAH LVA A A ++ P+ +++ Sbjct: 188 EDFAPFTNSGIVYKEGDDREAIMYQAAHYELVASARAVKI-GHAINPNLNIGCMVAMCPI 246 Query: 746 WAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPR 805 + NP A++ +Q + +FA+ + G YP + +Y K + Sbjct: 247 YPATCNP---KDILMAQKAMQ-KRYYFAD-VHVHGFYPEHIFKYWERK-------AIKVD 294 Query: 806 LTEAERR-LLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAV 864 TE +++ L +GTVD+ +++ + + + YD +++ +S + Sbjct: 295 FTERDKKDLFEGTVDYIGFSYYMSFVIDAHRENNPYYDYLETEDLVKNPYVKASDWDWQI 354 Query: 865 IPWGVRKLLRWVRRNYGDMDIYITASGID--DQALED----DRLRKYYLGKYLQEVLKAY 918 P G+R L W Y + ++I +G DQ D D R YLG +++E++KA Sbjct: 355 DPQGLRYALNWFTDMY-HLPLFIVENGFGAIDQVEADGMVHDDYRIDYLGAHIKEMIKAV 413 Query: 919 LIDKVRIKGYYAFKLAEEKS------KPRFGFFTSD----------FKAKSSIQFYNKVI 962 D V + GY + + S + R+GF D K S +Y +VI Sbjct: 414 DEDGVELMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDEGKGTLKRSPKLSFNWYKEVI 473 Query: 963 SSRG 966 +S G Sbjct: 474 ASNG 477 >2XHY-A nrPDB Length = 479 Score = 144 bits (362), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 129/484 (26%), Positives = 212/484 (43%), Gaps = 64/484 (13%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI---HTHLKNVSS---------TNGS 127 T PK+F WG A QVEG W K GKGPSI D H + ++ + + Sbjct: 7 TLPKDFLWGGAVAAHQVEGGWNKGGKGPSICDVLTGGAHGVPREITKEVLPGKYYPNHEA 66 Query: 128 SDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNI 187 D Y ++D+ +G ++ SI+W R+FP G N +GL++Y + D L+ NI Sbjct: 67 VDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPKGDEAQPNEEGLKFYDDMFDELLKYNI 126 Query: 188 EPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWIT---IHNP-- 242 EP++TL H+++PL L ++YG W N ++D F +A F+ + +VKYW+T I+N Sbjct: 127 EPVITLSHFEMPLHLVQQYGSWTNRKVVDFFVRFAEVVFERYKHKVKYWMTFNEINNQRN 186 Query: 243 YLVAWHGY-GTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLG 301 + GY +G+ + +Y V H+ A S + P K + L Sbjct: 187 WRAPLFGYCCSGVVYTEHENPEETMYQVLHHQFVA-SALAVKAARRINPEMK--VGCMLA 243 Query: 302 SHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGM----RKKLFSVLPIFSE 357 + P S N D+ Q+SM + + G YP + ++ F++ + Sbjct: 244 MVPLYP-YSCNPDDVMFAQESMRER--YVFTDVQLRGYYPSYVLNEWERRGFNIK--MED 298 Query: 358 AEKHEMR-GTADFFAFSFGPNNFKPLNTMAKMGQNVS----------------------L 394 + +R GT D+ FS+ N + G +S + Sbjct: 299 GDLDVLREGTCDYLGFSYYMTN--AVKAEGGTGDAISGFEGSVPNPYVKASDWGWQIDPV 356 Query: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVLQAIRLD 450 LR AL + Y P + I ENG+ +V+ + D I ++ + ++ +A+ D Sbjct: 357 GLRYALCELYERYQRP-LFIVENGFGAYDKVEEDGSINDDYRIDYLRAHIEEMKKAVTYD 415 Query: 451 EIRVFGYTAWSLLDGFEWQDA-YTIRRGLFYV---DFNSKQKERKPKSSAHYYKQIIREN 506 + + GYT W +D + Y+ R G YV D + R K S ++YK++I N Sbjct: 416 GVDLMGYTPWGCIDCVSFTTGQYSKRYGFIYVNKHDDGTGDMSRSRKKSFNWYKEVIASN 475 Query: 507 GFSL 510 G L Sbjct: 476 GEKL 479 Score = 75.9 bits (185), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 102/441 (23%), Positives = 179/441 (40%), Gaps = 78/441 (17%) Query: 575 QCTDFV-NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKL 633 + DF + K+ +++ A M +R ++ W + P G+ + N + L++Y + E LK Sbjct: 65 EAVDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPKGDEAQPNEEGLKFYDDMFDELLKY 124 Query: 634 GISAMVTLYYPTHAHLGLPEPLLHADG-WLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 I ++TL +H +P L+ G W N + F +A + F+ VK W+T N Sbjct: 125 NIEPVITL-----SHFEMPLHLVQQYGSWTNRKVVDFFVRFAEVVFERYKHKVKYWMTFN 179 Query: 693 EPNRLSD-------------IYNRSGN---DTYGAAHNLLVAHALAWRLYDRQFRPSQRG 736 E N + +Y N Y H+ VA ALA + R+ P + Sbjct: 180 EINNQRNWRAPLFGYCCSGVVYTEHENPEETMYQVLHHQFVASALAVKA-ARRINPEMKV 238 Query: 737 AVSLSLHADWAEPANP----YADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIAS 792 L++ + NP +A R F ++ G YP+ Y+ + Sbjct: 239 GCMLAMVPLYPYSCNPDDVMFAQESMRERYVFTDVQL---------RGYYPS----YVLN 285 Query: 793 K-HRRGLSSSALPRLTEAERRLLK-GTVDFCALNHFTTRFVMHEQLAG---SRYDSDRDI 847 + RRG + ++ + + +L+ GT D+ +++ T V E G S ++ Sbjct: 286 EWERRGFNI----KMEDGDLDVLREGTCDYLGFSYYMTNAVKAEGGTGDAISGFEGSVPN 341 Query: 848 QFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID--DQALED----DR 901 +++ +S + P G+R L + Y ++I +G D+ ED D Sbjct: 342 PYVK-----ASDWGWQIDPVGLRYALCELYERY-QRPLFIVENGFGAYDKVEEDGSINDD 395 Query: 902 LRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS------KPRFGFF--------TS 947 R YL +++E+ KA D V + GY + + S R+GF T Sbjct: 396 YRIDYLRAHIEEMKKAVTYDGVDLMGYTPWGCIDCVSFTTGQYSKRYGFIYVNKHDDGTG 455 Query: 948 DF--KAKSSIQFYNKVISSRG 966 D K S +Y +VI+S G Sbjct: 456 DMSRSRKKSFNWYKEVIASNG 476 >5NAV-A nrPDB Length = 477 Score = 138 bits (348), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 123/469 (26%), Positives = 210/469 (44%), Gaps = 52/469 (11%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG---SSDSYIFLEKD 137 FP+ F WG T Q EG++ K + +++D++ T + + G +S+ Y + D Sbjct: 20 FPEGFVWGAATSGPQTEGNFHKQHQ--NVFDYWFATEPEQFDAGVGPDTASNFYNDYDHD 77 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 L+ + GV + SI W RL D NA G+ +Y+ ++D+++ +I P + L+H+D Sbjct: 78 LALMAQAGVQGLRTSIQWTRLIDDFETASLNADGVAFYNHVIDSMLAHHITPYINLHHFD 137 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP+AL +KY GW++ ++++F +A CF++FGDRV +W T + P +V Y G H P Sbjct: 138 LPVALYDKYHGWESKHVVELFVKFAEQCFKLFGDRVDHWYTFNEPKVVVDGQYLYGWHYP 197 Query: 258 GEKGNLAAVYTVGHNLIKAHSK-VWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 AV V +N+ A +K V + RP Q+ + + L + S++ D+ Sbjct: 198 QVINGPKAV-QVAYNMNLASAKTVARFHELSVRPEQQIGIILNLTPAYAA---SDDPADL 253 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 + + + F +P G +PE + ++L ++ + +A E+ A S G Sbjct: 254 AAAEFAELWSNNLFLDPA-VLGHFPEKLVERL-TMDGVLWDATPTELAIIAANPVDSLGV 311 Query: 377 NNFKPLNT-----------------------MAKMGQNVSLN-------LREALNWIKLE 406 N + P M NV + + I+ Sbjct: 312 NYYHPFRVQRPDISPKSLQPWMPDIYFKEYDMPGRMMNVDRGWEIYPQAMTDIARNIQKN 371 Query: 407 YNNPRILIAENGW-------FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTA 459 Y N +I+ENG F D + +D I MK L+ + + I GY Sbjct: 372 YGNIPWMISENGMGVAGEERFLDKQGVVQDDYRIDFMKEHLTALAKGIAAGS-NCQGYFV 430 Query: 460 WSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 WS +D + W AY R GL D +++ K K SA ++ ++ NGF Sbjct: 431 WSGIDCWSWNHAYHNRYGLIRNDIHTQTKTL--KKSAKWFAELGERNGF 477 Score = 67.8 bits (164), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 100/447 (22%), Positives = 173/447 (38%), Gaps = 69/447 (15%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYV---WNATGNRLLHRVEGVRLKTRPAQC 576 +FP F WG S + E F H V W AT E P Sbjct: 19 EFPEGFVWGAATSGPQTEG-----NFHKQHQNVFDYWFAT------EPEQFDAGVGPDTA 67 Query: 577 TDFVN-IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 ++F N L ++A+ V R ++ W ++ +++N + +Y V+ L I Sbjct: 68 SNFYNDYDHDLALMAQAGVQGLRTSIQWTRLIDDFETASLNADGVAFYNHVIDSMLAHHI 127 Query: 636 SAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP 694 + + L+ H LP L GW + E F +A CF+ GD V W T NEP Sbjct: 128 TPYINLH-----HFDLPVALYDKYHGWESKHVVELFVKFAEQCFKLFGDRVDHWYTFNEP 182 Query: 695 NRLSD---IYN------RSGNDTYGAAHNLLVAHA-LAWRLYDRQFRPSQRGAVSLSLHA 744 + D +Y +G A+N+ +A A R ++ RP Q+ + L+L Sbjct: 183 KVVVDGQYLYGWHYPQVINGPKAVQVAYNMNLASAKTVARFHELSVRPEQQIGIILNLTP 242 Query: 745 DWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALP 804 +A +P AD AA F + ++ LF PA + + R L Sbjct: 243 AYAASDDP-AD---LAAAEFAEL----WSNNLFLD---PAVLGHFPEKLVERLTMDGVLW 291 Query: 805 RLTEAERRLLKGT-VDFCALNHFTTRFVMHEQLAGSRYDSDRDIQ-FLQDI--TRLSSPT 860 T E ++ VD +N++ V + S + +Q ++ DI P Sbjct: 292 DATPTELAIIAANPVDSLGVNYYHPFRVQRPDI------SPKSLQPWMPDIYFKEYDMPG 345 Query: 861 RL-------AVIPWGVRKLLRWVRRNYGDMDIYITASG---------IDDQALEDDRLRK 904 R+ + P + + R +++NYG++ I+ +G +D Q + D R Sbjct: 346 RMMNVDRGWEIYPQAMTDIARNIQKNYGNIPWMISENGMGVAGEERFLDKQGVVQDDYRI 405 Query: 905 YYLGKYLQEVLKAYLIDKVRIKGYYAF 931 ++ ++L + K + +GY+ + Sbjct: 406 DFMKEHLTALAKG-IAAGSNCQGYFVW 431 >4GZE-A nrPDB Length = 481 Score = 131 bits (329), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 132/482 (27%), Positives = 217/482 (45%), Gaps = 60/482 (12%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF-IHTHLKNVSSTNG-----------S 127 FP+ F WG A Q+EG +K+ GKG S D + T+ + T+G + Sbjct: 10 AFPEGFLWGGAVAAHQLEGGYKEGGKGLSTADIMTLGTNERPREITDGVVAGKYYPNHQA 69 Query: 128 SDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNI 187 D Y +D+ +G ++ SI+W R+FP+G + N GLQ+Y L D + I Sbjct: 70 IDFYHRYPEDIELFAEMGFKCFRTSIAWTRIFPNGDESEPNEAGLQFYDDLFDECLKNGI 129 Query: 188 EPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWIT---IHNPYL 244 +P+VTL H+++P L ++YGGW+N +I + ++A CF+ + D+V YW+T I+N Sbjct: 130 QPVVTLAHFEMPYHLVKQYGGWRNRKLIQFYLNFAKVCFERYRDKVTYWMTFNEINNQTN 189 Query: 245 VAWHG---YGTG-MHAPGEKGNLAAVYTVGHNLIKAHSKVW--HNYNTHFRPHQKGWLSI 298 G +G +H PGE + L+ + + V H N F+ + Sbjct: 190 FESDGAMLTDSGIIHQPGENRERWMYQAAHYELVASAAAVQLGHQINPDFQ------IGC 243 Query: 299 TLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV---LPIF 355 + I P + D+ Q++M + +FA+ +H +G YP+ +R + S L I Sbjct: 244 MIAMCPIYP-LTAAPADVLFAQRAMQTRF-YFAD-VHCNGTYPQWLRNRFESEHFNLDIT 300 Query: 356 SEAEKHEMRGTADFFAFSF---------GPNNFKPLNTMAKMG---------QNVSLNLR 397 +E K GT D+ FS+ G + + + K Q + LR Sbjct: 301 AEDLKILQAGTVDYIGFSYYMSFTVKDTGKLAYNEEHDLVKNPYVKASDWGWQVDPVGLR 360 Query: 398 EALNWIKLEYNNPRILIAENGW-FTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIR 453 A+NW Y+ P + I ENG D + + D I + + L Q+ A+ D + Sbjct: 361 YAMNWFTDRYHLP-LFIVENGLGAIDKKTADNQIHDDYRIDYLTDHLRQIKLAVLEDGVD 419 Query: 454 VFGYTAWSLLDGFEWQDAYTIRR-GLFYVDFN---SKQKERKPKSSAHYYKQIIRENGFS 509 + GYT W +D +R G YVD N S +R K S +++ +I NG Sbjct: 420 LIGYTPWGCIDLVAASTGQMSKRYGFIYVDENDDGSGSLKRYKKDSFTWFQHVIATNGAE 479 Query: 510 LK 511 ++ Sbjct: 480 IE 481 Score = 92.4 bits (228), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 112/438 (25%), Positives = 188/438 (42%), Gaps = 66/438 (15%) Query: 575 QCTDFVN-IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKL 633 Q DF + + +E+ A M +R ++ W + P G+ S N L++Y + E LK Sbjct: 68 QAIDFYHRYPEDIELFAEMGFKCFRTSIAWTRIFPNGDESEPNEAGLQFYDDLFDECLKN 127 Query: 634 GISAMVTLYYPTHAHLGLPEPLL-HADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI +VTL AH +P L+ GW N + + +A +CF+ D V W+T N Sbjct: 128 GIQPVVTL-----AHFEMPYHLVKQYGGWRNRKLIQFYLNFAKVCFERYRDKVTYWMTFN 182 Query: 693 EPNR----------LSD--IYNRSGND----TYGAAHNLLVAHALAWRLYDRQFRPSQRG 736 E N L+D I ++ G + Y AAH LVA A A +L Q P + Sbjct: 183 EINNQTNFESDGAMLTDSGIIHQPGENRERWMYQAAHYELVASAAAVQL-GHQINPDFQI 241 Query: 737 AVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRR 796 +++ + A P AD + A+R +Q +FA+ + G YP +R S+H Sbjct: 242 GCMIAMCPIYPLTAAP-ADVLF--AQRAMQTRF-YFAD-VHCNGTYPQWLRNRFESEHFN 296 Query: 797 GLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRL 856 L E + L GTVD+ +++ + V + Y+ + D+ +++ Sbjct: 297 ------LDITAEDLKILQAGTVDYIGFSYYMSFTV--KDTGKLAYNEEHDL--VKNPYVK 346 Query: 857 SSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGI--------DDQALEDDRLRKYYLG 908 +S V P G+R + W Y + ++I +G+ D+Q +D R+ YL Sbjct: 347 ASDWGWQVDPVGLRYAMNWFTDRY-HLPLFIVENGLGAIDKKTADNQIHDDYRID--YLT 403 Query: 909 KYLQEVLKAYLIDKVRIKGYYAFKLAE------EKSKPRFGFFTSDFK----------AK 952 +L+++ A L D V + GY + + + R+GF D K Sbjct: 404 DHLRQIKLAVLEDGVDLIGYTPWGCIDLVAASTGQMSKRYGFIYVDENDDGSGSLKRYKK 463 Query: 953 SSIQFYNKVISSRGFPFE 970 S ++ VI++ G E Sbjct: 464 DSFTWFQHVIATNGAEIE 481 >4B3K-A nrPDB Length = 479 Score = 126 bits (317), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 72/208 (34%), Positives = 111/208 (53%), Gaps = 6/208 (2%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTH---LKNVSSTNGSSDSYIFLEK 136 FPK F+WG T Q EG + K + +++D++ + + +SD+Y +E Sbjct: 2 AFPKEFWWGGATSGPQSEGRFAKQHR--NLFDYWYEEEPDLFYDYVGPDTASDAYHQIES 59 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 DL+ L +G + Y+ SI W RL D N GL YY+ ++DA + I P++ L+H+ Sbjct: 60 DLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRVIDACLANGIRPVINLHHF 119 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP+AL + YGGW++ ++D+F ++ CF+ FGDRVK W + P +V Y H Sbjct: 120 DLPIALYQAYGGWESKHVVDLFVAFSKVCFEQFGDRVKDWFVHNEPMVVVEGSYLMQFHY 179 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNY 284 P AV V +NL A +KV Y Sbjct: 180 PAIVDGKKAV-QVAYNLALATAKVIQAY 206 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 77/325 (23%), Positives = 125/325 (38%), Gaps = 38/325 (11%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYV---WNATGNRLLHRVEGVRLKTRPAQCT 577 FP +F WG S + E +F+ H + W L + G P + Sbjct: 3 FPKEFWWGGATSGPQSEG-----RFAKQHRNLFDYWYEEEPDLFYDYVG------PDTAS 51 Query: 578 D-FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS 636 D + I+ L +LA + YR ++ W ++ + +N L YY V+ L GI Sbjct: 52 DAYHQIESDLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRVIDACLANGIR 111 Query: 637 AMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP- 694 ++ L+ H LP L A GW + + F A++ +CF++ GD VK W NEP Sbjct: 112 PVINLH-----HFDLPIALYQAYGGWESKHVVDLFVAFSKVCFEQFGDRVKDWFVHNEPM 166 Query: 695 -----NRLSDIYNRS---GNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADW 746 + L + + G A+NL +A A + Y R G + L+ Sbjct: 167 VVVEGSYLMQFHYPAIVDGKKAVQVAYNLALATAKVIQAYRRGPAELSDGRIGTILNLTP 226 Query: 747 AEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRL 806 A PA S A F W + + + E +A + G+ + P Sbjct: 227 AYPA-----SQSEADMAAAHFAELWNNDLFMEAAVHGKFPEELVAVLKKDGVLWQSTP-- 279 Query: 807 TEAERRLLKGTVDFCALNHFTTRFV 831 E + + VD+ LN + + V Sbjct: 280 -EELALIAENRVDYLGLNFYHPKRV 303 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 10/111 (9%) Query: 403 IKLEYNNPRILIAENGW-------FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 ++ Y+N ++ENG + D + +D I +K L+ + + I F Sbjct: 352 MRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTYLHKGIEAGS-NCF 410 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 GY W+ +DG+ W +AY R GL V+ N + R+PK+SA+++K++ N Sbjct: 411 GYHVWTPIDGWSWLNAYKNRYGL--VENNIHTQVRRPKASAYWFKKVATHN 459 >1PBG-A nrPDB Length = 468 Score = 118 bits (296), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 73/201 (36%), Positives = 107/201 (53%), Gaps = 5/201 (2%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLS 139 T PK+F +G T A Q EG+ DGKGP WD ++ + + +SD Y DL Sbjct: 4 TLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEP--ASDFYHKYPVDLE 61 Query: 140 ALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLP 199 + GV+ + SI+W R+FP G V N KG+++Y L R++EP VTL+H+D P Sbjct: 62 LAEEYGVNGIRISIAWSRIFPTGYGEV-NEKGVEFYHKLFAECHKRHVEPFVTLHHFDTP 120 Query: 200 LALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGE 259 AL G + N I+ F DYA +CF+ F + V YW T + + Y G PG Sbjct: 121 EALHSN-GDFLNRENIEHFIDYAAFCFEEFPE-VNYWTTFNEIGPIGDGQYLVGKFPPGI 178 Query: 260 KGNLAAVYTVGHNLIKAHSKV 280 K +LA V+ HN++ +H++ Sbjct: 179 KYDLAKVFQSHHNMMVSHARA 199 Score = 82.4 bits (202), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 100/423 (23%), Positives = 169/423 (39%), Gaps = 58/423 (13%) Query: 585 QLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYP 644 LE+ V R ++ W+ + PTG VN + + +Y + +E K + VTL+ Sbjct: 59 DLELAEEYGVNGIRISIAWSRIFPTG-YGEVNEKGVEFYHKLFAECHKRHVEPFVTLH-- 115 Query: 645 THAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRS 704 H PE L +LN E F YA CF+E + V W T NE + D Sbjct: 116 ---HFDTPEALHSNGDFLNRENIEHFIDYAAFCFEEFPE-VNYWTTFNEIGPIGDGQYLV 171 Query: 705 GN----------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYA 754 G + + HN++V+HA A +LY + + G V +P NP A Sbjct: 172 GKFPPGIKYDLAKVFQSHHNMMVSHARAVKLYKDKGYKGEIGVVHALPTKYPYDPENP-A 230 Query: 755 DSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRL- 813 D E + + A L G Y E + H + L E + L Sbjct: 231 DVRAAELEDIIHNKFILDATYL---GHYSDKTMEGV--NHILAENGGELDLRDEDFQALD 285 Query: 814 -LKGTVDFCALNHFTTRFVMH-----EQLAGSRYDSDRDIQFLQDITRLSSPTRLA---- 863 K DF +N++ + ++ E + + + ++ + R +P + Sbjct: 286 AAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRVAPDYVPRTDW 345 Query: 864 ---VIPWGVRKLLRWVRRNYGDM-DIYITASG-------IDDQALEDDRLRKYYLGKYLQ 912 + P G+ + V+ +Y + IYIT +G +D+ +D R+ Y+ ++L Sbjct: 346 DWIIYPEGLYDQIMRVKNDYPNYKKIYITENGLGYKDEFVDNTVYDDGRID--YVKQHL- 402 Query: 913 EVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDFKA-----KSSIQFYNKVI 962 EVL + D +KGY+ + L + S + R+G F DF K S +Y K+ Sbjct: 403 EVLSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDTQERYPKKSAHWYKKLA 462 Query: 963 SSR 965 ++ Sbjct: 463 ETQ 465 Score = 65.1 bits (157), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/113 (40%), Positives = 62/113 (54%), Gaps = 11/113 (9%) Query: 396 LREALNWIKLEYNN-PRILIAENGW-----FTDSRVKTEDTTAIYMMKNFLSQVLQAIRL 449 L + + +K +Y N +I I ENG F D+ V D I +K L + AI Sbjct: 354 LYDQIMRVKNDYPNYKKIYITENGLGYKDEFVDNTVY--DDGRIDYVKQHLEVLSDAI-A 410 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI 502 D V GY WSL+D F W + Y R GLFYVDF++ +ER PK SAH+YK++ Sbjct: 411 DGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDT--QERYPKKSAHWYKKL 461 >4R27-A nrPDB Length = 434 Score = 108 bits (271), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 111/444 (25%), Positives = 187/444 (42%), Gaps = 48/444 (10%) Query: 77 LYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIW--DHFIHTHLKNVSSTNGSSDSYIFL 134 + + FP++F WG+ T QVEG + +W +H T S + D Y Sbjct: 3 MTNPFPQDFLWGVATAGHQVEG----NNVNSDVWFLEHLPGTIFAEPSGD--AVDHYHRY 56 Query: 135 EKDLSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTL 193 +D++ + +G + Y+FS+ W R+ P +G +VA L +Y +L+A + P+VT Sbjct: 57 REDIALIAGLGFTSYRFSVEWARIEPEEGHFSVA---ALDHYKRVLEACREHGLTPVVTF 113 Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAW--HGYG 251 +H+ PL L + GGW+ + ++F Y GD + T++ P L W +G Sbjct: 114 HHFASPLWLL-RSGGWEGERTPELFARYCGRVMAHLGDLIGVACTLNEPNL-PWLLESFG 171 Query: 252 TGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSE 311 G AP +G + L S V F + G ++ L +H + Sbjct: 172 IGGEAPENRGKVPMWAAAAQRLGVDASTV---APFQFCSTEAG-FNVKLAAH-------K 220 Query: 312 NTMDIFKCQQSMVSVLGW-FAN----PIHGDGDYPEGMRKKLFSVLPIFSEAEK-HEMRG 365 + K + + V GW AN + G + +R+ V F EA + + G Sbjct: 221 AATEAIKAHRPDLRV-GWTLANSDIQSVPGGEEIAAQVRR---DVNERFLEASRGDDFVG 276 Query: 366 TADFFAFSFGPNNFKPLN---TMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTD 422 + +GP+ P + +MG+ + EA +++ ENG T+ Sbjct: 277 IQTYGRTVYGPDGHAPAPEGVAVNQMGEEIYPQALEATIREAWRVAGIPVMVTENGLATE 336 Query: 423 SRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVD 482 +DT + ++ + V + D I V GY AW+ D FEW Y + GL VD Sbjct: 337 -----DDTQRVAYLRTAVDGVASCL-ADGIDVRGYIAWTAFDNFEWIFGYGPKFGLIAVD 390 Query: 483 FNSKQKERKPKSSAHYYKQIIREN 506 ++ +ER PK SA + R+ Sbjct: 391 RST--QERTPKESARWLGNFARQQ 412 Score = 65.9 bits (159), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 23/177 (12%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD-F 579 FP DF WGV + + E ++ + VW L + G D + Sbjct: 7 FPQDFLWGVATAGHQVEG-------NNVNSDVW------FLEHLPGTIFAEPSGDAVDHY 53 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPT-GNLSAVNRQALRYYRCVVSEGLKLGISAM 638 ++ + ++A + T YRF+++WA + P G+ S AL +Y+ V+ + G++ + Sbjct: 54 HRYREDIALIAGLGFTSYRFSVEWARIEPEEGHFSVA---ALDHYKRVLEACREHGLTPV 110 Query: 639 VTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 VT + H P LL + GW T E F Y G LGDL+ + T+NEPN Sbjct: 111 VTFH-----HFASPLWLLRSGGWEGERTPELFARYCGRVMAHLGDLIGVACTLNEPN 162 >1VFF-A nrPDB Length = 423 Score = 95.5 bits (236), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 110/440 (25%), Positives = 191/440 (43%), Gaps = 56/440 (12%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSS-DSYIFLEKDLS 139 FP+ F +G T + Q+EG+ + + D + + + + +G + + + D+ Sbjct: 5 FPEMFLFGTATSSHQIEGNNRWN-------DWWYYEQIGKLPYRSGKACNHWELYRDDIQ 57 Query: 140 ALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLP 199 + +G + Y+FSI W RLFP+ N Y ++D L+ R I P+VTL+H+ P Sbjct: 58 LMTSLGYNAYRFSIEWSRLFPEE--NKFNEDAFMKYREIIDLLLTRGITPLVTLHHFTSP 115 Query: 200 LALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGE 259 L +K GG+ + + + Y ++ ++VK T + P + GY T P Sbjct: 116 LWFMKK-GGFLREENLKHWEKYIEKVAELL-EKVKLVATFNEPMVYVMMGYLTAYWPPFI 173 Query: 260 KGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKC 319 + A + V NL+KAH+ + + F+ + I L + E +R K Sbjct: 174 RSPFKA-FKVAANLLKAHAIAYELLHGKFKVGIVKNIPIILPASDKERDR--------KA 224 Query: 320 QQSMVSVLGW-FANPIHGDGDYPEGMRKKLFSVLPI-FSEAE--------KHEMRGTADF 369 + ++ W F + I G + +F I S+A+ E+R T + Sbjct: 225 AEKADNLFNWHFLDAIWS------GKYRGVFKTYRIPQSDADFIGVNYYTASEVRHTWNP 278 Query: 370 FAFSFGPNNFKPLNTMAKMG-----QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSR 424 F F +MG + + + L++A Y P + I ENG T Sbjct: 279 LKFFFEVKLADISERKTQMGWSVYPKGIYMALKKASR-----YGRP-LYITENGIAT--- 329 Query: 425 VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFN 484 +D + + L V +AI D + V GY WS +D +EW++ + R GL VD+ Sbjct: 330 --LDDEWRVEFIIQHLQYVHKAIE-DGLDVRGYFYWSFMDNYEWKEGFGPRFGLVEVDYQ 386 Query: 485 SKQKERKPKSSAHYYKQIIR 504 + ER+P+ SA+ Y +I R Sbjct: 387 T--FERRPRKSAYVYGEIAR 404 Score = 74.7 bits (182), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 100/409 (24%), Positives = 168/409 (41%), Gaps = 67/409 (16%) Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 C + + ++++ + YRF+++W+ + P N N A YR ++ L GI Sbjct: 46 CNHWELYRDDIQLMTSLGYNAYRFSIEWSRLFPEEN--KFNEDAFMKYREIIDLLLTRGI 103 Query: 636 SAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 + +VTL+ H P + G+L + ++ Y EL + VKL T NEP Sbjct: 104 TPLVTLH-----HFTSPLWFMKKGGFLREENLKHWEKYIEKV-AELLEKVKLVATFNEPM 157 Query: 696 RLSDI---------YNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADW 746 + + RS + A NLL AHA+A+ L +F+ + + L A Sbjct: 158 VYVMMGYLTAYWPPFIRSPFKAFKVAANLLKAHAIAYELLHGKFKVGIVKNIPIILPASD 217 Query: 747 AEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRL 806 E +AAE+ A+ LF A I S RG+ + Sbjct: 218 KERDR-------KAAEK---------ADNLFNWHFLDA-----IWSGKYRGVFKTY---- 252 Query: 807 TEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIP 866 R+ + DF +N++T V H + + L DI+ + +V P Sbjct: 253 -----RIPQSDADFIGVNYYTASEVRHTWNPLKFFFEVK----LADISERKTQMGWSVYP 303 Query: 867 WGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIK 926 G+ L+ R YG +YIT +GI A DD R ++ ++LQ V KA + D + ++ Sbjct: 304 KGIYMALKKASR-YG-RPLYITENGI---ATLDDEWRVEFIIQHLQYVHKA-IEDGLDVR 357 Query: 927 GYYAFKLAE-----EKSKPRFGFFTSDF-----KAKSSIQFYNKVISSR 965 GY+ + + E PRFG D+ + + S Y ++ S+ Sbjct: 358 GYFYWSFMDNYEWKEGFGPRFGLVEVDYQTFERRPRKSAYVYGEIARSK 406 >1QVB-A nrPDB Length = 481 Score = 72.4 bits (176), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 111/491 (22%), Positives = 188/491 (38%), Gaps = 86/491 (17%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSD-------SYIF 133 FPK+F G + Q E S W ++H +N ++ S D + Sbjct: 3 FPKDFMIGYSSSPFQFEAGIPGSEDPNSDWWVWVHDP-ENTAAGLVSGDFPENGPGYWNL 61 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTV--------------------------- 166 + D + +GV+ + + W R+FP V Sbjct: 62 NQNDHDLAEKLGVNTIRVGVEWSRIFPKPTFNVKVPVERDENGSIVHVDVDDKAVERLDE 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKY-----------GGWKNDTI 214 AN + + +Y + V R + I+ LYHW LPL L GW N+ Sbjct: 122 LANKEAVNHYVEMYKDWVERGRKLILNLYHWPLPLWLHNPIMVRRMGPDRAPSGWLNEES 181 Query: 215 IDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYG--TGMHAPGEKGNLAAVYTVGHN 272 + F YA Y G+ W T++ P +V GY G PG +L A N Sbjct: 182 VVEFAKYAAYIAWKMGELPVMWSTMNEPNVVYEQGYMFVKGGFPPGYL-SLEAADKARRN 240 Query: 273 LIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFAN 332 +I+AH++ + N + K + + W E E ++F +S S L +F + Sbjct: 241 MIQAHARAYDN----IKRFSKKPVGLIYAFQWFE--LLEGPAEVFDKFKS--SKLYYFTD 292 Query: 333 PIHGDG-----DYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG----PNNFKPL- 382 + +Y + +L + + +++ +G P P Sbjct: 293 IVSKGSSIINVEYRRDLANRLDWLGVNYYSRLVYKIVDDKPIILHGYGFLCTPGGISPAE 352 Query: 383 NTMAKMG-----QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMK 437 N + G + + L L+E N ++ +++ ENG +DSR + Y++ Sbjct: 353 NPCSDFGWEVYPEGLYLLLKELYNRYGVD-----LIVTENG-VSDSR---DALRPAYLVS 403 Query: 438 NFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAH 497 + S V +A + I V GY WSL D +EW + + GL VDF +K++ +P SA Sbjct: 404 HVYS-VWKAAN-EGIPVKGYLHWSLTDNYEWAQGFRQKFGLVMVDFKTKKRYLRP--SAL 459 Query: 498 YYKQIIRENGF 508 +++I NG Sbjct: 460 VFREIATHNGI 470 Score = 57.0 bits (136), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 118/526 (22%), Positives = 204/526 (38%), Gaps = 129/526 (24%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPH--LYVWNATGNRLLHRVE----GVRLKTRP 573 +FP DF G + S + E A P DP+ +VW +H E G+ P Sbjct: 2 KFPKDFMIGYSSSPFQFE--AGIPGSEDPNSDWWVW-------VHDPENTAAGLVSGDFP 52 Query: 574 AQCTDFVNIKKQLEMLA-RMKVTHYRFALDWASVLP--------------TGNLSAV--- 615 + N+ + LA ++ V R ++W+ + P G++ V Sbjct: 53 ENGPGYWNLNQNDHDLAEKLGVNTIRVGVEWSRIFPKPTFNVKVPVERDENGSIVHVDVD 112 Query: 616 -----------NRQALRYYRCVVSEGLKLGISAMVTLY-YPTHAHLGLP------EPLLH 657 N++A+ +Y + + ++ G ++ LY +P L P P Sbjct: 113 DKAVERLDELANKEAVNHYVEMYKDWVERGRKLILNLYHWPLPLWLHNPIMVRRMGPDRA 172 Query: 658 ADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD---IYNRSG--------N 706 GWLN + F YA ++G+L +W T+NEPN + + ++ + G Sbjct: 173 PSGWLNEESVVEFAKYAAYIAWKMGELPVMWSTMNEPNVVYEQGYMFVKGGFPPGYLSLE 232 Query: 707 DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQ 766 A N++ AHA R YD R S++ V L W E AE F + Sbjct: 233 AADKARRNMIQAHA---RAYDNIKRFSKK-PVGLIYAFQWFELLE-------GPAEVFDK 281 Query: 767 FEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHF 826 F+ + L+ D + I ++RR L++ +D+ +N++ Sbjct: 282 FK----SSKLYYFTDIVSKGSSIINVEYRRDLANR----------------LDWLGVNYY 321 Query: 827 TTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLA------------VIPWGVRKLLR 874 +R V + D+ I L L +P ++ V P G+ LL+ Sbjct: 322 -SRLVY-------KIVDDKPI-ILHGYGFLCTPGGISPAENPCSDFGWEVYPEGLYLLLK 372 Query: 875 WVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLA 934 + YG +D+ +T +G+ D D LR YL ++ V KA + + +KGY + L Sbjct: 373 ELYNRYG-VDLIVTENGVSDSR---DALRPAYLVSHVYSVWKA-ANEGIPVKGYLHWSLT 427 Query: 935 E-----EKSKPRFGFFTSDFKAKS-----SIQFYNKVISSRGFPFE 970 + + + +FG DFK K S + ++ + G P E Sbjct: 428 DNYEWAQGFRQKFGLVMVDFKTKKRYLRPSALVFREIATHNGIPDE 473 >3WDP-P nrPDB Length = 473 Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 114/487 (23%), Positives = 181/487 (37%), Gaps = 104/487 (21%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSD------SYIFL 134 FPKNF +G Q E + S W ++H +N++S S D +Y L Sbjct: 4 FPKNFMFGYSWSGFQFEMG-LPGSEVESDWWVWVHDK-ENIASGLVSGDLPENGPAYWHL 61 Query: 135 EK-DLSALDFIGVSFYQFSISWPRLFPD---------------GIVTV------------ 166 K D + +G+ + I W R+FP I++V Sbjct: 62 YKQDHDIAEKLGMDCIRGGIEWARIFPKPTFDVKVDVEKDEEGNIISVDVPESTIKELEK 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQE-----KYG------GWKNDTI 214 AN + L++Y + R I+ LYHW LPL + + K G GW ++ Sbjct: 122 IANMEALEHYRKIYSDWKERGKTFILNLYHWPLPLWIHDPIAVRKLGPDAAPAGWLDEKT 181 Query: 215 IDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLI 274 + F +A + D V W T++ P +V GY NLA+ + G Sbjct: 182 VVEFVKFAAFVAYHLDDLVDMWSTMNEPNVVYNQGYI----------NLASGFPPGFLSF 231 Query: 275 KAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPI 334 +A K N + +G++ SE ++ + + W Sbjct: 232 EAAEKAKFNL-----------IQAHIGAYDAIKEYSEKSVGV-------IYAFAWHDPLA 273 Query: 335 HGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN--FKPL---------N 383 D E +RKK + + I K + G + +G + PL Sbjct: 274 EEYKDEVEEIRKKDYEFVTILHSKGKLDWIGVNYYSRLVYGAKDGHLVPLPGYGFMSERG 333 Query: 384 TMAKMGQNVS--------LNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYM 435 AK G+ S L L ++ Y P I I ENG D + Sbjct: 334 GFAKSGRPASDFGWEMYPEGLENLLKYLNNAYELPMI-ITENG-----MADAADRYRPHY 387 Query: 436 MKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSS 495 + + L V A++ + V GY WSL D +EW + +R GL YVDF +K++ +P S Sbjct: 388 LVSHLKAVYNAMK-EGADVRGYLHWSLTDNYEWAQGFRMRFGLVYVDFETKKRYLRP--S 444 Query: 496 AHYYKQI 502 A +++I Sbjct: 445 ALVFREI 451 Score = 57.0 bits (136), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 101/431 (23%), Positives = 171/431 (39%), Gaps = 117/431 (27%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLP--------------TGNLSAV------------- 615 K+ ++ ++ + R ++WA + P GN+ +V Sbjct: 63 KQDHDIAEKLGMDCIRGGIEWARIFPKPTFDVKVDVEKDEEGNIISVDVPESTIKELEKI 122 Query: 616 -NRQALRYYRCVVSEGLKLGISAMVTLYY---PTHAHLGLPEPLLHAD----GWLNPSTA 667 N +AL +YR + S+ + G + ++ LY+ P H + L D GWL+ T Sbjct: 123 ANMEALEHYRKIYSDWKERGKTFILNLYHWPLPLWIHDPIAVRKLGPDAAPAGWLDEKTV 182 Query: 668 EAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRS----------GNDTYGAAH---- 713 F +A L DLV +W T+NEPN +YN+ G ++ AA Sbjct: 183 VEFVKFAAFVAYHLDDLVDMWSTMNEPNV---VYNQGYINLASGFPPGFLSFEAAEKAKF 239 Query: 714 NLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP-ANPYADSHWRAAERFLQFEIAWF 772 NL+ AH A YD S++ +V + W +P A Y D Sbjct: 240 NLIQAHIGA---YDAIKEYSEK-SVGVIYAFAWHDPLAEEYKDE---------------- 279 Query: 773 AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVM 832 E + K DY E++ H KG +D+ +N++ +R V Sbjct: 280 VEEIRKK-DY-----EFVTILHS-------------------KGKLDWIGVNYY-SRLVY 313 Query: 833 HEQ------LAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIY 886 + L G + S+R R +S + P G+ LL+++ Y ++ + Sbjct: 314 GAKDGHLVPLPGYGFMSER--GGFAKSGRPASDFGWEMYPEGLENLLKYLNNAY-ELPMI 370 Query: 887 ITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPR 941 IT +G+ D A DR R +YL +L+ V A + + ++GY + L + + + R Sbjct: 371 ITENGMADAA---DRYRPHYLVSHLKAVYNA-MKEGADVRGYLHWSLTDNYEWAQGFRMR 426 Query: 942 FGFFTSDFKAK 952 FG DF+ K Sbjct: 427 FGLVYVDFETK 437 >4HA4-A nrPDB Length = 489 Score = 61.2 bits (147), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 117/514 (22%), Positives = 198/514 (38%), Gaps = 110/514 (21%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPH--LYVW-NATGNRLLHRVEGVRLKTRPAQCT 577 FP DF +G +++ + E +P DP+ Y W + N V G + P Sbjct: 4 FPKDFLFGWSQAGFQSE--MGTPGSEDPNSDWYAWVHDRENIAAGLVSGDFPENGPGY-- 59 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA----------------------- 614 + N +K + M +T R ++W+ + P Sbjct: 60 -WGNYRKFHDAAQAMGLTAARIGVEWSRIFPRPTFDVKVDAEVKGDDVLSVYVSEGALEQ 118 Query: 615 ----VNRQALRYYRCVVSEGLKLGISAMVTLY-YPTHAHLGLPEPLLHAD-----GWLNP 664 NR A+ +YR + S+ GI+ ++ LY +P L P + + GWL+ Sbjct: 119 LDKMANRDAINHYREMFSDLRSRGITFILNLYHWPLPLWLHDPIAIRRGNLSAPSGWLDV 178 Query: 665 STAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYG-----------AAH 713 T F ++ +L DLV ++ T+NEPN + + + + A Sbjct: 179 RTVIEFAKFSAYVAWKLDDLVYMYSTMNEPNVVWGLGYAAVKSGFPPGYLCLECAGRAMK 238 Query: 714 NLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFA 773 NL+ AHA R YD +++ + ++D+ P D+ AAER +F+ W Sbjct: 239 NLVQAHA---RAYDAVKAITKKPVGVIYANSDF----TPLTDADREAAER-AKFDNRW-- 288 Query: 774 EPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVM- 832 + A +R +L + R LKG +D+ +N++T + V Sbjct: 289 ------AFFDAVVRG----------------QLGGSTRDDLKGRLDWIGVNYYTRQVVRA 326 Query: 833 ----HEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLR--WVRRNYGDMDIY 886 +E + G Y + + R S P G+ +L+ W R + + + Sbjct: 327 RGSGYEIVPG--YGHGCEPNGVSPAGRPCSDFGWEFYPEGLYNVLKEYWDRYH---LPLL 381 Query: 887 ITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS-----KPR 941 +T +GI D E D R YYL ++ +V +A L D V + GY + LA+ R Sbjct: 382 VTENGIAD---EGDYQRPYYLVSHVYQVHRA-LQDGVNVIGYLHWSLADNYEWASGFSKR 437 Query: 942 FGFFTSDFKAK-----SSIQFYNKVISSRGFPFE 970 FG D+ K S Y ++ SR E Sbjct: 438 FGLLMVDYSTKRLHWRPSAFIYREIAKSRAITDE 471 Score = 51.6 bits (122), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 59/115 (51%), Gaps = 12/115 (10%) Query: 412 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 +L+ ENG + D Y + + + QV +A++ D + V GY WSL D +EW Sbjct: 380 LLVTENGIADEG-----DYQRPYYLVSHVYQVHRALQ-DGVNVIGYLHWSLADNYEWASG 433 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLK----ESTPDVQGQFP 522 ++ R GL VD+++K+ +P SA Y++I + + + S P ++G P Sbjct: 434 FSKRFGLLMVDYSTKRLHWRP--SAFIYREIAKSRAITDEIEHLNSVPPLRGLSP 486 Score = 48.1 bits (113), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 91/247 (36%), Gaps = 46/247 (18%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSD-------SYI 132 TFPK+F +G Q E S W ++H +N+++ S D + Sbjct: 3 TFPKDFLFGWSQAGFQSEMGTPGSEDPNSDWYAWVHDR-ENIAAGLVSGDFPENGPGYWG 61 Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFP--------------DGIVTV------------ 166 K A +G++ + + W R+FP D +++V Sbjct: 62 NYRKFHDAAQAMGLTAARIGVEWSRIFPRPTFDVKVDAEVKGDDVLSVYVSEGALEQLDK 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYG----------GWKNDTII 215 AN + +Y + L R I I+ LYHW LPL L + GW + + Sbjct: 122 MANRDAINHYREMFSDLRSRGITFILNLYHWPLPLWLHDPIAIRRGNLSAPSGWLDVRTV 181 Query: 216 DIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA-PGEKGNLAAVYTVGHNLI 274 F ++ Y D V + T++ P +V GY P L NL+ Sbjct: 182 IEFAKFSAYVAWKLDDLVYMYSTMNEPNVVWGLGYAAVKSGFPPGYLCLECAGRAMKNLV 241 Query: 275 KAHSKVW 281 +AH++ + Sbjct: 242 QAHARAY 248 >1GOW-A nrPDB Length = 489 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 82/367 (22%), Positives = 142/367 (38%), Gaps = 66/367 (17%) Query: 615 VNRQALRYYRCVVSEGLKLGISAMVTLY-YPTHAHLGLPEPLLHAD-----GWLNPSTAE 668 N+ AL +YR + + G+ + +Y +P L P + D GWL+ T Sbjct: 122 ANKDALNHYREIFKDLKSRGLYFIQNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVY 181 Query: 669 AFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYG-----------AAHNLLV 717 F ++ + DLV + T+NEPN + + + A +N++ Sbjct: 182 EFARFSAYTAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQ 241 Query: 718 AHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLF 777 AHA R YD S++ + ++ + P D A E WF Sbjct: 242 AHA---RAYDGIKSVSKKPVGIIYANSSF----QPLTDKDMEAVEMAENDNRWWF----- 289 Query: 778 KTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQ-- 835 + A +R I + + + R LKG +D+ +N++T V + Sbjct: 290 ----FDAIIRGEITRGNEKIV------------RDDLKGRLDWIGVNYYTRTVVKRTEKG 333 Query: 836 ---LAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLR--WVRRNYGDMDIYITAS 890 L G + +R+ L + +S P G+ +L W R + + +Y+T + Sbjct: 334 YVSLGGYGHGCERNSVSLAGLP--TSDFGWEFFPEGLYDVLTKYWNRYH---LYMYVTEN 388 Query: 891 GIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS-----KPRFGFF 945 GI D A D R YYL ++ +V +A + ++GY + LA+ RFG Sbjct: 389 GIADDA---DYQRPYYLVSHVYQVHRA-INSGADVRGYLHWSLADNYEWASGFSMRFGLL 444 Query: 946 TSDFKAK 952 D+ K Sbjct: 445 KVDYNTK 451 Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 8/91 (8%) Query: 412 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 + + ENG D+ D Y + + + QV +AI V GY WSL D +EW Sbjct: 383 MYVTENGIADDA-----DYQRPYYLVSHVYQVHRAIN-SGADVRGYLHWSLADNYEWASG 436 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQI 502 +++R GL VD+N+K+ +P SA Y++I Sbjct: 437 FSMRFGLLKVDYNTKRLYWRP--SALVYREI 465 Score = 35.0 bits (79), Expect = 0.16, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 35/86 (40%), Gaps = 10/86 (11%) Query: 167 ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKY----------GGWKNDTIID 216 AN L +Y + L R + I +YHW LPL L + GW + + Sbjct: 122 ANKDALNHYREIFKDLKSRGLYFIQNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVY 181 Query: 217 IFNDYATYCFQMFGDRVKYWITIHNP 242 F ++ Y F D V + T++ P Sbjct: 182 EFARFSAYTAWKFDDLVDEYSTMNEP 207 >3ZPX-A nrPDB Length = 458 Score = 31.6 bits (70), Expect = 1.7, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 18/32 (56%) Query: 245 VAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA 276 + ++GY G HA G NLA Y HN+I A Sbjct: 168 IGFYGYSGGAHATGWAANLAGSYAPEHNIIGA 199 >2D7R-A nrPDB Length = 570 Score = 31.2 bits (69), Expect = 2.7, Method: Compositional matrix adjust. Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 9/60 (15%) Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF--------SLKESTPDVQ 518 +W D IRR V N +Q P + A Q RENGF SL S PD++ Sbjct: 40 DWHDKEAIRRDAQRVG-NGEQGRPYPMTDAERVDQAYRENGFNIYVSDKISLNRSLPDIR 98 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5VAQ-A nrPDB 1328 0.0 5W21-A nrPDB 1093 0.0 5WI9-A nrPDB 661 0.0 4GXP-A nrPDB 596 e-170 5YJ7-A nrPDB 571 e-163 2DGA-A nrPDB 569 e-162 3WBE-A nrPDB 569 e-162 3ZJ8-A nrPDB 569 e-162 3AIW-A nrPDB 566 e-161 3WQ4-A nrPDB 561 e-160 2CBU-A nrPDB 556 e-158 3AHY-A nrPDB 554 e-158 1V02-A nrPDB 554 e-158 2RGL-A nrPDB 550 e-156 4MDP-A nrPDB 550 e-156 3PTM-A nrPDB 550 e-156 5BWF-A nrPDB 549 e-156 3VKK-A nrPDB 549 e-156 3AHX-A nrPDB 546 e-155 5JBO-A nrPDB 546 e-155 4A3Y-A nrPDB 546 e-155 4PTW-A nrPDB 546 e-155 1QOX-A nrPDB 545 e-155 5IDI-A nrPDB 543 e-154 5OGZ-A nrPDB 541 e-154 2E40-A nrPDB 539 e-153 1BGG-A nrPDB 539 e-153 1CBG-A nrPDB 533 e-151 1E55-A nrPDB 529 e-150 5XGZ-A nrPDB 529 e-150 4HZ6-A nrPDB 527 e-150 3VIK-A nrPDB 526 e-149 4JIE-A nrPDB 524 e-148 1WCG-A nrPDB 520 e-147 5AYI-A nrPDB 518 e-147 2Z1S-A nrPDB 512 e-145 5GNX-A nrPDB 510 e-144 5DT5-A nrPDB 504 e-143 5CG0-A nrPDB 503 e-142 5NS7-A nrPDB 499 e-141 3W53-A nrPDB 495 e-140 1GNX-A nrPDB 487 e-137 4ZEN-A nrPDB 483 e-136 5YHS-A nrPDB 482 e-136 5WKA-A nrPDB 482 e-136 1W9D-M nrPDB 467 e-131 3ZJK-A nrPDB 465 e-131 2XHY-A nrPDB 446 e-125 4F66-A nrPDB 429 e-120 4IPN-B nrPDB 421 e-117 1PBG-A nrPDB 418 e-117 4GZE-A nrPDB 417 e-116 5NAV-A nrPDB 416 e-116 4B3K-A nrPDB 408 e-114 1VFF-A nrPDB 367 e-101 4HA4-A nrPDB 362 e-100 1QVB-A nrPDB 353 3e-97 4R27-A nrPDB 341 1e-93 3WDP-P nrPDB 337 2e-92 1GOW-A nrPDB 307 2e-83 Sequences not found previously or not previously below threshold: 3NCO-A nrPDB 46 8e-05 6D8G-A nrPDB 42 0.001 4EKJ-A nrPDB 40 0.006 4JKL-A nrPDB 39 0.015 4IM4-A nrPDB 39 0.015 5NQA-A nrPDB 38 0.019 3AZS-A nrPDB 38 0.021 5Z19-A nrPDB 37 0.033 1CEO-A nrPDB 37 0.051 4UCF-A nrPDB 36 0.058 5H4R-A nrPDB 36 0.089 3NJ3-A nrPDB 36 0.11 3AYR-A nrPDB 35 0.13 5D8Z-A nrPDB 35 0.17 6BJW-A nrPDB 35 0.18 4UOQ-A nrPDB 35 0.20 5BX9-A nrPDB 35 0.21 5J7Z-A nrPDB 35 0.24 6ECA-A nrPDB 34 0.45 6FCG-A nrPDB 33 0.49 4YMX-A nrPDB 33 0.65 6ETZ-A nrPDB 33 0.67 6CXS-A nrPDB 33 1.0 3CMG-A nrPDB 32 1.7 3ZMS-C nrPDB 32 1.7 4B3J-A nrPDB 31 2.0 5T99-A nrPDB 31 2.6 5XZO-A nrPDB 31 2.6 3ZPX-A nrPDB 31 2.7 5E0C-A nrPDB 31 2.8 6GL0-A nrPDB 31 3.1 5KH2-A nrPDB 31 3.6 5Z1B-A nrPDB 31 3.8 1OY5-A nrPDB 30 4.2 3L5H-A nrPDB 30 4.2 1W3H-A nrPDB 30 5.0 4IEH-A nrPDB 30 5.0 3CFV-B nrPDB 30 5.5 1XC6-A nrPDB 30 6.0 5Y1U-A nrPDB 30 7.5 4V2X-A nrPDB 30 8.6 4XX6-A nrPDB 29 9.4 >5VAQ-A nrPDB Length = 954 Score = 1328 bits (3438), Expect = 0.0, Method: Composition-based stats. Identities = 952/954 (99%), Positives = 952/954 (99%) Query: 30 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI 89 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI Sbjct: 1 MSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGI 60 Query: 90 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY 149 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY Sbjct: 61 GTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFY 120 Query: 150 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW 209 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW Sbjct: 121 QFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGW 180 Query: 210 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV 269 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV Sbjct: 181 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTV 240 Query: 270 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGW 329 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEP RSENTMDIFKCQQSMVSVLGW Sbjct: 241 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQQSMVSVLGW 300 Query: 330 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG 389 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG Sbjct: 301 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMG 360 Query: 390 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL 449 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL Sbjct: 361 QNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRL 420 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS Sbjct: 421 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 480 Query: 510 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL 569 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL Sbjct: 481 LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRL 540 Query: 570 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSE 629 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTG LSAVNRQALRYYRCVVSE Sbjct: 541 KTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGQLSAVNRQALRYYRCVVSE 600 Query: 630 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI 689 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI Sbjct: 601 GLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWI 660 Query: 690 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP Sbjct: 661 TINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 720 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA Sbjct: 721 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 780 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV Sbjct: 781 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 840 Query: 870 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 929 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY Sbjct: 841 RKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 900 Query: 930 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT 983 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT Sbjct: 901 AFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENT 954 >5W21-A nrPDB Length = 981 Score = 1093 bits (2826), Expect = 0.0, Method: Composition-based stats. Identities = 444/964 (46%), Positives = 614/964 (63%), Gaps = 42/964 (4%) Query: 55 GDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI 114 GDG W++ P E+ TFP F W +G+ A Q EG W++ GKG SIWD F Sbjct: 36 GDGAQTWARFSR-PPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFT 94 Query: 115 HTHLK------------------NVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWP 156 H L ++ + +SDSY + +D AL +GV+ Y+FSISW Sbjct: 95 HHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWA 154 Query: 157 RLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIID 216 R+ P+G V N +GL+YY LL+ L ++P+VTLYHWDLP LQ+ YGGW N + D Sbjct: 155 RVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALAD 214 Query: 217 IFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA 276 F DYA CF+ FG +VKYWITI NPY+VAWHGY TG APG +G+ Y V HNL+ A Sbjct: 215 HFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLA 274 Query: 277 HSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHG 336 H+KVWH YNT FRP Q G +SI L SHWI P R + I +CQ+S+ VLGWFA P+ Sbjct: 275 HAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTD-HSIKECQKSLDFVLGWFAKPVFI 333 Query: 337 DGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPN-NFKPLNTMAKMGQNVSLN 395 DGDYPE M+ L S+LP F+E+EK ++GTADFFA FGP +F+ L+ K Q S N Sbjct: 334 DGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPN 393 Query: 396 LREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 LR+ L+WI LE+N+P+I I ENGWF K +D +Y +K F+ + L+AI+LD + V Sbjct: 394 LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVI 453 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTP 515 GYTAWSL+DGFEW Y+IRRGLFYVDF S+ K PKSSA +Y+++I +NGF Sbjct: 454 GYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQ 513 Query: 516 DVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQ 575 ++G FPCDF+WGV ++ ++ ++ S QF+D ++Y+W+ ++ L +V+GV K R + Sbjct: 514 PLEGTFPCDFAWGVVDNYIQVDTTLS--QFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSY 571 Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 C DF I+ Q+ +L M VTH+RF+LDWA +LP GN S VN L+YYRC+ SE +++ I Sbjct: 572 CVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNI 631 Query: 636 SAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 + +V L+ P + GLP L W NP TA AF YA LCFQELG VKLWIT+NEP Sbjct: 632 TPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPY 691 Query: 696 RLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYAD 755 N TY A HNLL AHALAW +Y+ +FR +Q G +S++L ADW EPA P++ Sbjct: 692 TR--------NMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQ 743 Query: 756 SHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLK 815 AER L+F+I W AEP+F +GDYP MR+++ + ++ LP TE E++L++ Sbjct: 744 KDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQR-----NNFLLPYFTEDEKKLIQ 798 Query: 816 GTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRW 875 GT DF AL+H+TT V E+ +Y+ ++Q + DIT L+SP+++AV+PWG+RK+L W Sbjct: 799 GTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNW 858 Query: 876 VRRNYGDMDIYITASGIDDQA-LEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLA 934 ++ YGD+ +YI ++GIDD EDD+LR YY+ Y+ E LKA+++D + + GY+A+ Sbjct: 859 LKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFN 918 Query: 935 EEKSKPRFGFF---TSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFL 991 + ++ PRFG + F+ K+S++ Y K+I S GFP + R +E T CT C F Sbjct: 919 D-RTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFC-PEEFTVCTECSFF 976 Query: 992 VQKK 995 +K Sbjct: 977 HTRK 980 >5WI9-A nrPDB Length = 470 Score = 661 bits (1705), Expect = 0.0, Method: Composition-based stats. Identities = 457/458 (99%), Positives = 457/458 (99%) Query: 52 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD 111 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD Sbjct: 1 GFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWD 60 Query: 112 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG 171 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG Sbjct: 61 HFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG 120 Query: 172 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD 231 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD Sbjct: 121 LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGD 180 Query: 232 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 291 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH Sbjct: 181 RVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 240 Query: 292 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 351 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV Sbjct: 241 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 300 Query: 352 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR 411 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR Sbjct: 301 LPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPR 360 Query: 412 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA Sbjct: 361 ILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 420 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF Sbjct: 421 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFE 458 Score = 412 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 130/498 (26%), Positives = 210/498 (42%), Gaps = 72/498 (14%) Query: 496 AHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNA 555 A + K N + ES + FP +F WG+ L+ E +W+ Sbjct: 8 AIWSKN---PNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPS---IWDH 61 Query: 556 TGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAV 615 + L V + ++ ++K L L + V+ Y+F++ W + P G ++ Sbjct: 62 FIHTHLKNVSSTNGSS-----DSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA 116 Query: 616 NRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYA 674 N + L+YY ++ + I +VTLY H LP L GW N + + F YA Sbjct: 117 NAKGLQYYSTLLDALVLRNIEPIVTLY-----HWDLPLALQEKYGGWKNDTIIDIFNDYA 171 Query: 675 GLCFQELGDLVKLWITINEPNRLSDIYNRSGNDT----------YGAAHNLLVAHALAWR 724 CFQ GD VK WITI+ P ++ +G Y HNL+ AH+ W Sbjct: 172 TYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWH 231 Query: 725 LYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPA 784 Y+ FRP Q+G +S++L + W EP ++ + + WFA P+ GDYP Sbjct: 232 NYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPE 291 Query: 785 AMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSD 844 MR+ + S LP +EAE+ ++GT DF A + Sbjct: 292 GMRKKLFS---------VLPIFSEAEKHEMRGTADFFAFSF-----------------GP 325 Query: 845 RDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG--IDDQALEDDRL 902 + + L + ++ L +R+ L W++ Y + I I +G D + +D Sbjct: 326 NNFKPLNTMAKMGQNVSL-----NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTT 380 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEK-----SKPRFGFFTSDF-------K 950 Y + +L +VL+A +D++R+ GY A+ L + R G F DF K Sbjct: 381 AIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERK 440 Query: 951 AKSSIQFYNKVISSRGFP 968 KSS +Y ++I GF Sbjct: 441 PKSSAHYYKQIIRENGFE 458 >4GXP-A nrPDB Length = 467 Score = 596 bits (1538), Expect = e-170, Method: Composition-based stats. Identities = 157/464 (33%), Positives = 238/464 (51%), Gaps = 43/464 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT KN + + + D Y ++D+ Sbjct: 13 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 72 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ +GV Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ + I P VT++HWDL Sbjct: 73 EIIEKLGVKAYRFSISWPRILPEGTGRV-NQKGLDFYNRIIDTLLEKGITPFVTIFHWDL 131 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ K GG N I D F +Y+ F+ FGDRVK WIT + P A GYG+G APG Sbjct: 132 PFALQLK-GGLLNREIADWFAEYSRVLFENFGDRVKNWITFNEPLCSAIPGYGSGTFAPG 190 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + + + +TVGHN++ AH + + + G + I L + P + + D Sbjct: 191 RQ-STSEPWTVGHNILVAHGRAVKVFRETVK---DGKIGIVLNGDFTYPWDAADPADKEA 246 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ + WFA+PI+ GDYP MRK+L LP F+ E+ + G+ DF+ + +N Sbjct: 247 AERRLEFFTAWFADPIYL-GDYPASMRKQLGDRLPTFTPEERALVHGSNDFYGMNHYTSN 305 Query: 379 FKP--------------------------LNTMAKMGQ--NVSLNLREALNWIKLEYNNP 410 + + M + R+ L WI Y P Sbjct: 306 YIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETAMPWLRPCAAGFRDFLVWISKRYGYP 365 Query: 411 RILIAENGWFTDS----RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 I + ENG D + D I +K ++ ++ A+ LD + V GY WSLLD F Sbjct: 366 PIYVTENGAAFDDVVSEDGRVHDQNRIDYLKAYIGAMVTAVELDGVNVKGYFVWSLLDNF 425 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 EW + Y+ R G+ YVD+++++ R K S ++Y +++ NG Sbjct: 426 EWAEGYSKRFGIVYVDYSTQK--RIVKDSGYWYSNVVKNNGLED 467 Score = 540 bits (1391), Expect = e-153, Method: Composition-based stats. Identities = 137/481 (28%), Positives = 220/481 (45%), Gaps = 56/481 (11%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + E SP + +W+ + + G T C + Sbjct: 12 KFPEGFLWGVATASYQIEG---SPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 65 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ V YRF++ W +LP G VN++ L +Y ++ L+ GI+ V Sbjct: 66 NRWKEDIEIIEKLGVKAYRFSISWPRILPEGT-GRVNQKGLDFYNRIIDTLLEKGITPFV 124 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 T++ H LP L G LN A+ F Y+ + F+ GD VK WIT NEP + Sbjct: 125 TIF-----HWDLPFALQLKGGLLNREIADWFAEYSRVLFENFGDRVKNWITFNEPLCSAI 179 Query: 700 IYNRSGN---------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 SG + + HN+LVAH A +++ + G + + L+ D+ P Sbjct: 180 PGYGSGTFAPGRQSTSEPWTVGHNILVAHGRAVKVFRETVK---DGKIGIVLNGDFTYPW 236 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + + AAER L+F AWFA+P++ GDYPA+MR+ + + LP T E Sbjct: 237 DAADPADKEAAERRLEFFTAWFADPIY-LGDYPASMRKQLGDR---------LPTFTPEE 286 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQD------ITRLSSPTRLAV 864 R L+ G+ DF +NH+T+ ++ H S D+ ++ L I ++ L Sbjct: 287 RALVHGSNDFYGMNHYTSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETAMPWLRP 346 Query: 865 IPWGVRKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAY 918 G R L W+ + YG IY+T +G DD ED D+ R YL Y+ ++ A Sbjct: 347 CAAGFRDFLVWISKRYGYPPIYVTENGAAFDDVVSEDGRVHDQNRIDYLKAYIGAMVTAV 406 Query: 919 LIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFP 968 +D V +KGY+ + L + RFG D+ K S +Y+ V+ + G Sbjct: 407 ELDGVNVKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLE 466 Query: 969 F 969 Sbjct: 467 D 467 >5YJ7-A nrPDB Length = 518 Score = 571 bits (1471), Expect = e-163, Method: Composition-based stats. Identities = 162/470 (34%), Positives = 242/470 (51%), Gaps = 41/470 (8%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKD 137 FP+ F WG T A Q+EG+ +DG+GPS+WD F K N + + + D Y ++D Sbjct: 30 AFPEGFLWGAATAAYQIEGAAAEDGRGPSMWDTFSKIPGKIDNGDTGDVACDHYHRYKED 89 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FS+SW R+ P+G + N KG+++Y L + L+ I P VTLYHWD Sbjct: 90 VKLMKGMGLKSYRFSVSWSRVLPEGTGAI-NPKGMEFYQNLTNELIANGIVPTVTLYHWD 148 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP AL K GGW N+ F YA FQ GDRVK W T++ P+ A GYG G HAP Sbjct: 149 LPEAL-SKNGGWLNEDTAVAFGQYADVMFQALGDRVKLWFTLNEPWTTAIAGYGQGGHAP 207 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G K Y GHN + H+ Y ++ Q G + L + W EP D Sbjct: 208 GLKNMAENPYMAGHNQLLGHAAAVKVYREKYQEKQGGKIGAVLSTEWKEP-LCHTQEDKD 266 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP- 376 ++S++ L WFA+PI+ GDYPE M++++ +P F+E +K +++G+ADFF + Sbjct: 267 AAERSLIWYLAWFADPIY-KGDYPEEMKERVGDRMPAFTEQQKQDLKGSADFFGINHYAT 325 Query: 377 -------------NNFKPLNTMAKMGQN-----------VSLNLREALNWIKLEYNNPRI 412 N F LN M V +R L WIK Y++P + Sbjct: 326 NLLQGPTEKIGAENYFSDLNGWIMMDPRWAVGDASWLSVVPWGMRRLLRWIKHRYDDPVV 385 Query: 413 LIAENGWFTDS------RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 + ENG + D + ++ +++++ +AI D+++V GY WSLLD F Sbjct: 386 YVTENGLSVPNESAMTPEAALNDKMRVDYLQGYVAEMWKAINYDKVKVAGYYHWSLLDNF 445 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPD 516 EW D Y +R GL VD+ +++ R K SA YK +I + +S + PD Sbjct: 446 EWSDGYKVRFGLVQVDYKTQK--RTLKESAKVYKDMIAK--YSGDTAPPD 491 Score = 506 bits (1303), Expect = e-143, Method: Composition-based stats. Identities = 150/487 (30%), Positives = 234/487 (48%), Gaps = 54/487 (11%) Query: 508 FSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGV 567 + +E FP F WG + + E A+ +W+ G Sbjct: 18 LTAEEVFASKDTAFPEGFLWGAATAAYQIEGAAAEDGRGPS---MWDTFSKIPGKIDNG- 73 Query: 568 RLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVV 627 T C + K+ ++++ M + YRF++ W+ VLP G A+N + + +Y+ + Sbjct: 74 --DTGDVACDHYHRYKEDVKLMKGMGLKSYRFSVSWSRVLPEGT-GAINPKGMEFYQNLT 130 Query: 628 SEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKL 687 +E + GI VTLY H LPE L GWLN TA AF YA + FQ LGD VKL Sbjct: 131 NELIANGIVPTVTLY-----HWDLPEALSKNGGWLNEDTAVAFGQYADVMFQALGDRVKL 185 Query: 688 WITINEPNRLSDIYNRSG----------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGA 737 W T+NEP + G + Y A HN L+ HA A ++Y +++ Q G Sbjct: 186 WFTLNEPWTTAIAGYGQGGHAPGLKNMAENPYMAGHNQLLGHAAAVKVYREKYQEKQGGK 245 Query: 738 VSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRG 797 + L +W EP + AAER L + +AWFA+P++K GDYP M+E + + Sbjct: 246 IGAVLSTEWKEPLC-HTQEDKDAAERSLIWYLAWFADPIYK-GDYPEEMKERVGDR---- 299 Query: 798 LSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMH--EQLAGSRYDSDRDIQFLQDITR 855 +P TE +++ LKG+ DF +NH+ T + E++ Y SD + + D Sbjct: 300 -----MPAFTEQQKQDLKGSADFFGINHYATNLLQGPTEKIGAENYFSDLNGWIMMDPRW 354 Query: 856 -LSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG--------IDDQALEDDRLRKYY 906 + + L+V+PWG+R+LLRW++ Y D +Y+T +G + +A +D++R Y Sbjct: 355 AVGDASWLSVVPWGMRRLLRWIKHRYDDPVVYVTENGLSVPNESAMTPEAALNDKMRVDY 414 Query: 907 LGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQ 956 L Y+ E+ KA DKV++ GYY + L + K RFG D+K K S + Sbjct: 415 LQGYVAEMWKAINYDKVKVAGYYHWSLLDNFEWSDGYKVRFGLVQVDYKTQKRTLKESAK 474 Query: 957 FYNKVIS 963 Y +I+ Sbjct: 475 VYKDMIA 481 >2DGA-A nrPDB Length = 565 Score = 569 bits (1467), Expect = e-162, Method: Composition-based stats. Identities = 154/489 (31%), Positives = 242/489 (49%), Gaps = 56/489 (11%) Query: 65 PNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVS-- 122 P FT + Q+ D F K+F +G T A Q+EG+W +DGKGPS WDHF HT+ + +S Sbjct: 58 PVFTKLKPWQIPKRDWFDKDFLFGASTSAYQIEGAWNEDGKGPSTWDHFCHTYPERISDM 117 Query: 123 -STNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 181 + + +++SY E+D+ AL +G+ Y+FSISW R+ PDG V N G+ YY+ L+++ Sbjct: 118 TNGDVAANSYHLYEEDVKALKDMGMKVYRFSISWSRILPDGTGKV-NQAGIDYYNKLINS 176 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 L+ +I P VT++HWD P AL++KYGG+ N I+D + +A CF+ FGDRVK W T + Sbjct: 177 LIDNDIVPYVTIWHWDTPQALEDKYGGFLNRQIVDDYKQFAEVCFKNFGDRVKNWFTFNE 236 Query: 242 PYLVAWHGYGTGMHAPGEK-----------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRP 290 P+ YG G+HAPG +L YT GH+++ AH++ + + Sbjct: 237 PHTYCCFSYGEGIHAPGRCSPGMDCAVPEGDSLREPYTAGHHILLAHAEAVQLFKARYNM 296 Query: 291 HQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS 350 H + + EP + ++ +D ++S+ +GWF P+ GDYP MR + Sbjct: 297 HGDSKIGMAFDVMGYEPYQ-DSFLDDQARERSIDYNMGWFLEPV-VRGDYPFSMRSLIGD 354 Query: 351 VLPIFSEAEKHEMRGTADFFAFSFGPNNFKPL--------------------NTMAKMGQ 390 LP+F++ E+ ++ + D ++ + F T G Sbjct: 355 RLPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDMSPDFTPTLNTDDAYASSETTGSDGN 414 Query: 391 NV------------SLNLREALNWIKLEYNNPRILIAENGWFTDS-----RVKTEDTTAI 433 ++ L + L +K +Y NP + I ENG +D + Sbjct: 415 DIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPVFITENGIADVEGDESMPDPLDDWKRL 474 Query: 434 YMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPK 493 ++ +S V AI V G+ W L+D FEW Y+ R GL Y+D N K RK K Sbjct: 475 DYLQRHISAVKDAIDQ-GADVRGHFTWGLIDNFEWSLGYSSRFGLVYIDKNDGNK-RKLK 532 Query: 494 SSAHYYKQI 502 SA ++ + Sbjct: 533 KSAKWFSKF 541 Score = 473 bits (1218), Expect = e-133, Method: Composition-based stats. Identities = 118/539 (21%), Positives = 211/539 (39%), Gaps = 80/539 (14%) Query: 482 DFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVAS 541 D + K P A + + LK + F DF +G + S + E + Sbjct: 39 DDDDKAMAGTPSKPAEPIGPVFTK----LKPWQIPKRDWFDKDFLFGASTSAYQIEGAWN 94 Query: 542 SPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFAL 601 W+ + R+ + + ++ ++ L M + YRF++ Sbjct: 95 EDGKGPS---TWDHFCHTYPERIS--DMTNGDVAANSYHLYEEDVKALKDMGMKVYRFSI 149 Query: 602 DWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DG 660 W+ +LP G VN+ + YY +++ + I VT++ H P+ L G Sbjct: 150 SWSRILPDGT-GKVNQAGIDYYNKLINSLIDNDIVPYVTIW-----HWDTPQALEDKYGG 203 Query: 661 WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSG--------------- 705 +LN + ++ +A +CF+ GD VK W T NEP+ G Sbjct: 204 FLNRQIVDDYKQFAEVCFKNFGDRVKNWFTFNEPHTYCCFSYGEGIHAPGRCSPGMDCAV 263 Query: 706 ------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWR 759 + Y A H++L+AHA A +L+ ++ + ++ EP + Sbjct: 264 PEGDSLREPYTAGHHILLAHAEAVQLFKARYNMHGDSKIGMAFDVMGYEPYQDSFLDD-Q 322 Query: 760 AAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVD 819 A ER + + + WF EP+ + GDYP +MR I + LP T+ E+ L + D Sbjct: 323 ARERSIDYNMGWFLEPVVR-GDYPFSMRSLIGDR---------LPMFTKEEQEKLASSCD 372 Query: 820 FCALNHFTTRFVMHEQLAGSRYD----------SDRDIQFLQDITRLSSPTRLAVIPWGV 869 LN++T+RF H ++ S+ DI ++ + + P G+ Sbjct: 373 IMGLNYYTSRFSKHVDMSPDFTPTLNTDDAYASSETTGSDGNDIGPITGTYWIYMYPKGL 432 Query: 870 RKLLRWVRRNYGDMDIYITASGIDDQALE-------DDRLRKYYLGKYLQEVLKAYLIDK 922 LL ++ YG+ ++IT +GI D + DD R YL +++ V A + Sbjct: 433 TDLLLIMKEKYGNPPVFITENGIADVEGDESMPDPLDDWKRLDYLQRHISAVKDA-IDQG 491 Query: 923 VRIKGYYAFKLAEE-----KSKPRFGFFTSD------FKAKSSIQFYNKVISSRGFPFE 970 ++G++ + L + RFG D K K S ++++K P Sbjct: 492 ADVRGHFTWGLIDNFEWSLGYSSRFGLVYIDKNDGNKRKLKKSAKWFSKF---NSVPKP 547 >3WBE-A nrPDB Length = 489 Score = 569 bits (1466), Expect = e-162, Method: Composition-based stats. Identities = 163/482 (33%), Positives = 247/482 (51%), Gaps = 55/482 (11%) Query: 75 LFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYI 132 +FP+ F +G + A Q EG+ K+DG+G +IWD F HT K + S+ + + D Y Sbjct: 12 GLTRGSFPEGFVFGTASAAYQYEGAVKEDGRGQTIWDTFAHTFGKITDFSNADVAVDQYH 71 Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVT 192 E+D+ + +G+ Y+FSI+W R++P+G+ V N G+ +Y+ L+DAL+ + I+P VT Sbjct: 72 RFEEDIQLMADMGMDAYRFSIAWSRIYPNGVGQV-NQAGIDHYNKLIDALLAKGIQPYVT 130 Query: 193 LYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGT 252 LYHWDLP AL++KY GW + I+D F YA CF+ FGDRVK+WIT++ P+ VA GY Sbjct: 131 LYHWDLPQALEDKYKGWLDRQIVDDFAAYAETCFREFGDRVKHWITLNQPHTVAIQGYDA 190 Query: 253 GMHAPGEK-----------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLG 301 G+ APG + Y V H+ I AH+ Y T ++ Q G L I Sbjct: 191 GLQAPGRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAAAASIYRTKYKATQNGQLGIAFD 250 Query: 302 SHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKH 361 W EP S T+DI +++ LGWFA+P GDYP MR ++ LP F+ E Sbjct: 251 VMWFEP-MSNTTIDIEAAKRAQEFQLGWFADPFFF-GDYPATMRARVGERLPRFTADEAA 308 Query: 362 EMRGTADFFAFSFGPNNFKPLNTMAKMG-------------------------------- 389 ++G DF + + N +G Sbjct: 309 VVKGALDFVGINHYTTYYTRHNNTNIIGTLLNNTLADTGTVSLPFKNGKPIGDRANSIWL 368 Query: 390 QNVSLNLREALNWIKLEYNNPRILIAENGW------FTDSRVKTEDTTAIYMMKNFLSQV 443 V +R +N++K YN+P + I ENG F + +D+ I ++L+ + Sbjct: 369 YIVPRGMRSLMNYVKERYNSPPVYITENGMDDSNNPFISIKDALKDSKRIKYHNDYLTNL 428 Query: 444 LQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 +I+ D V GY AWSLLD +EW Y+ R GL++VD+ K R PK+S ++K ++ Sbjct: 429 AASIKEDGCDVRGYFAWSLLDNWEWAAGYSSRFGLYFVDYKDNLK-RYPKNSVQWFKALL 487 Query: 504 RE 505 + Sbjct: 488 KT 489 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 125/498 (25%), Positives = 216/498 (43%), Gaps = 74/498 (14%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 +G FP F +G + + E +W+ + + Sbjct: 15 RGSFPEGFVFGTASAAYQYEGAVKEDGRG---QTIWDTFAHTFGKITD---FSNADVAVD 68 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637 + ++ ++++A M + YRF++ W+ + P G + VN+ + +Y ++ L GI Sbjct: 69 QYHRFEEDIQLMADMGMDAYRFSIAWSRIYPNG-VGQVNQAGIDHYNKLIDALLAKGIQP 127 Query: 638 MVTLYYPTHAHLGLPEPLLHAD-GWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 VTLY H LP+ L GWL+ + F AYA CF+E GD VK WIT+N+P+ Sbjct: 128 YVTLY-----HWDLPQALEDKYKGWLDRQIVDDFAAYAETCFREFGDRVKHWITLNQPHT 182 Query: 697 LSDIYN---------------------RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQR 735 ++ SG + Y AH+ ++AHA A +Y +++ +Q Sbjct: 183 VAIQGYDAGLQAPGRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAAAASIYRTKYKATQN 242 Query: 736 GAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHR 795 G + ++ W EP + AA+R +F++ WFA+P F GDYPA MR + + Sbjct: 243 GQLGIAFDVMWFEPMS-NTTIDIEAAKRAQEFQLGWFADPFF-FGDYPATMRARVGER-- 298 Query: 796 RGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL----- 850 LPR T E ++KG +DF +NH+TT + H + + Sbjct: 299 -------LPRFTADEAAVVKGALDFVGINHYTTYYTRHNNTNIIGTLLNNTLADTGTVSL 351 Query: 851 -----QDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQA--------L 897 + I ++ L ++P G+R L+ +V+ Y +YIT +G+DD Sbjct: 352 PFKNGKPIGDRANSIWLYIVPRGMRSLMNYVKERYNSPPVYITENGMDDSNNPFISIKDA 411 Query: 898 EDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK-- 950 D R Y YL + + D ++GY+A+ L + RFG + D+K Sbjct: 412 LKDSKRIKYHNDYLTNLAASIKEDGCDVRGYFAWSLLDNWEWAAGYSSRFGLYFVDYKDN 471 Query: 951 ----AKSSIQFYNKVISS 964 K+S+Q++ ++ + Sbjct: 472 LKRYPKNSVQWFKALLKT 489 >3ZJ8-A nrPDB Length = 532 Score = 569 bits (1466), Expect = e-162, Method: Composition-based stats. Identities = 156/494 (31%), Positives = 239/494 (48%), Gaps = 52/494 (10%) Query: 58 RAIWSKNPNFTPVNESQLFL-YDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHT 116 + N + PV S++ + FP++F +G G A Q EG++ + +GPSIWD F Sbjct: 19 ASTEHTNSHLIPVTRSKIVVHRRDFPQDFIFGAGGSAYQCEGAYNEGNRGPSIWDTFTQR 78 Query: 117 ---HLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGI-VTVANAKGL 172 + + S+ N + + Y ++D+ + G+ Y+FSISW R+ P G N G+ Sbjct: 79 SPAKISDGSNGNQAINCYHMYKEDIKIMKQTGLESYRFSISWSRVLPGGRLAAGVNKDGV 138 Query: 173 QYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDR 232 ++Y +D L+ I+P VTL+HWDLP AL+++YGG+ + I+D F +YA +CF FGD+ Sbjct: 139 KFYHDFIDELLANGIKPSVTLFHWDLPQALEDEYGGFLSHRIVDDFCEYAEFCFWEFGDK 198 Query: 233 VKYWITIHNPYLVAWHGYGTGMHAPGEK------GNLAAVYTVGHNLIKAHSKVWHNYNT 286 +KYW T + P+ A +GY G APG Y V HN++ AH Y Sbjct: 199 IKYWTTFNEPHTFAVNGYALGEFAPGRGGKGDEGDPAIEPYVVTHNILLAHKAAVEEYRN 258 Query: 287 HFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRK 346 F+ Q+G + I L S W+EP S+ DI ++++ +LGWF P+ GDYP+ MR+ Sbjct: 259 KFQKCQEGEIGIVLNSMWMEP-LSDVQADIDAQKRALDFMLGWFLEPLTT-GDYPKSMRE 316 Query: 347 KLFSVLPIFSEAEKHEMRGTADFFAFSFGP----------------------------NN 378 + LP FS + +++G DF ++ N Sbjct: 317 LVKGRLPKFSADDSEKLKGCYDFIGMNYYTATYVTNAVKSNSEKLSYETDDQVTKTFERN 376 Query: 379 FKPLNTMAKMGQN--VSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKT------EDT 430 KP+ G V L + L + K Y+ P + + E+G +++ K D Sbjct: 377 QKPIGHALYGGWQHVVPWGLYKLLVYTKETYHVPVLYVTESGMVEENKTKILLSEARRDA 436 Query: 431 TAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKER 490 + L+ V AI D + V GY WS D FEW Y R G+ +VD+ K ER Sbjct: 437 ERTDYHQKHLASVRDAID-DGVNVKGYFVWSFFDNFEWNLGYICRYGIIHVDY--KSFER 493 Query: 491 KPKSSAHYYKQIIR 504 PK SA +YK I Sbjct: 494 YPKESAIWYKNFIA 507 Score = 476 bits (1225), Expect = e-134, Method: Composition-based stats. Identities = 130/502 (25%), Positives = 211/502 (42%), Gaps = 66/502 (13%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 + FP DF +G S + E + +W+ R ++ + C Sbjct: 40 RRDFPQDFIFGAGGSAYQCEGAYNEGNRGPS---IWDTFTQRSPAKISDGSNGNQAINC- 95 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGIS 636 + K+ ++++ + + YRF++ W+ VLP G L+A VN+ +++Y + E L GI Sbjct: 96 -YHMYKEDIKIMKQTGLESYRFSISWSRVLPGGRLAAGVNKDGVKFYHDFIDELLANGIK 154 Query: 637 AMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 VTL+ H LP+ L G+L+ + F YA CF E GD +K W T NEP+ Sbjct: 155 PSVTLF-----HWDLPQALEDEYGGFLSHRIVDDFCEYAEFCFWEFGDKIKYWTTFNEPH 209 Query: 696 RLSDIYNRSGN----------------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 + G + Y HN+L+AH A Y +F+ Q G + Sbjct: 210 TFAVNGYALGEFAPGRGGKGDEGDPAIEPYVVTHNILLAHKAAVEEYRNKFQKCQEGEIG 269 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 + L++ W EP + + A +R L F + WF EPL TGDYP +MRE + + Sbjct: 270 IVLNSMWMEPLSD-VQADIDAQKRALDFMLGWFLEPL-TTGDYPKSMRELVKGR------ 321 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL--------Q 851 LP+ + + LKG DF +N++T +V + + S S + + Sbjct: 322 ---LPKFSADDSEKLKGCYDFIGMNYYTATYVTNAVKSNSEKLSYETDDQVTKTFERNQK 378 Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQ--------ALEDDRLR 903 I V+PWG+ KLL + + Y +Y+T SG+ ++ D R Sbjct: 379 PIGHALYGGWQHVVPWGLYKLLVYTKETYHVPVLYVTESGMVEENKTKILLSEARRDAER 438 Query: 904 KYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK-----AKS 953 Y K+L V A + D V +KGY+ + + R+G D+K K Sbjct: 439 TDYHQKHLASVRDA-IDDGVNVKGYFVWSFFDNFEWNLGYICRYGIIHVDYKSFERYPKE 497 Query: 954 SIQFYNKVISSRGFPFENSSSR 975 S +Y I+ + R Sbjct: 498 SAIWYKNFIAGKSTTSPAKRRR 519 >3AIW-A nrPDB Length = 564 Score = 566 bits (1460), Expect = e-161, Method: Composition-based stats. Identities = 153/489 (31%), Positives = 241/489 (49%), Gaps = 56/489 (11%) Query: 65 PNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVS-- 122 P FT + Q+ D F K+F +G T A Q+EG+W +DGKGPS WDHF HT+ + +S Sbjct: 58 PVFTKLKPWQIPKRDWFSKDFLFGASTSAYQIEGAWNEDGKGPSTWDHFCHTYPERISDG 117 Query: 123 -STNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 181 + + +++SY E+D+ AL +G+ Y+FSISW R+ P+G N KG+ YY+ L+++ Sbjct: 118 TNGDVAANSYHMYEEDVKALKDMGMKVYRFSISWSRILPNGTGK-PNQKGIDYYNNLINS 176 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 L+ I P VT++HWD P AL++KYGG+ + I++ + +A CFQ FGDRVK W T + Sbjct: 177 LIRHGIVPYVTIWHWDTPQALEDKYGGFLDKQIVNDYKYFAELCFQSFGDRVKNWFTFNE 236 Query: 242 PYLVAWHGYGTGMHAPGEK-----------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRP 290 P+ YG G+HAPG +L YT GH+++ AH++ + H+ Sbjct: 237 PHTYCCFSYGEGIHAPGRCSPGLDCAVPEGDSLREPYTAGHHILLAHAEAVELFKAHYNK 296 Query: 291 HQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS 350 H + + EP + ++ +D ++S+ +GWF P+ GDYP MR + Sbjct: 297 HGDSKIGMAFDVMGYEPYQ-DSFLDDQARERSIDYNMGWFLEPV-VRGDYPFSMRSLIGD 354 Query: 351 VLPIFSEAEKHEMRGTADFFAFSFGPNNFKPL--------------------NTMAKMGQ 390 LP+F++ E+ ++ + D ++ + F T G Sbjct: 355 RLPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDISSDYTPTLNTDDAYASSETTGSDGN 414 Query: 391 NV------------SLNLREALNWIKLEYNNPRILIAENGWFT-----DSRVKTEDTTAI 433 + L + L +K +Y NP I I ENG + +D + Sbjct: 415 EIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPIFITENGIADVEGDPEMPDPLDDWKRL 474 Query: 434 YMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPK 493 ++ +S V AI V G+ W L+D FEW Y+ R GL Y+D K RK K Sbjct: 475 DYLQRHISAVKDAIDQ-GADVRGHFTWGLIDNFEWGSGYSSRFGLVYIDKEDGNK-RKLK 532 Query: 494 SSAHYYKQI 502 SA ++ + Sbjct: 533 KSAKWFAKF 541 Score = 469 bits (1206), Expect = e-132, Method: Composition-based stats. Identities = 112/496 (22%), Positives = 198/496 (39%), Gaps = 73/496 (14%) Query: 516 DVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQ 575 + F DF +G + S + E + W+ + R+ Sbjct: 69 PKRDWFSKDFLFGASTSAYQIEGAWNEDGKGPS---TWDHFCHTYPERIS--DGTNGDVA 123 Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 + ++ ++ L M + YRF++ W+ +LP G N++ + YY +++ ++ GI Sbjct: 124 ANSYHMYEEDVKALKDMGMKVYRFSISWSRILPNGT-GKPNQKGIDYYNNLINSLIRHGI 182 Query: 636 SAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP 694 VT++ H P+ L G+L+ ++ +A LCFQ GD VK W T NEP Sbjct: 183 VPYVTIW-----HWDTPQALEDKYGGFLDKQIVNDYKYFAELCFQSFGDRVKNWFTFNEP 237 Query: 695 NRLSDIYNRSG---------------------NDTYGAAHNLLVAHALAWRLYDRQFRPS 733 + G + Y A H++L+AHA A L+ + Sbjct: 238 HTYCCFSYGEGIHAPGRCSPGLDCAVPEGDSLREPYTAGHHILLAHAEAVELFKAHYNKH 297 Query: 734 QRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASK 793 + ++ EP +A ER + + + WF EP+ + GDYP +MR I + Sbjct: 298 GDSKIGMAFDVMGYEPYQDSFLDD-QARERSIDYNMGWFLEPVVR-GDYPFSMRSLIGDR 355 Query: 794 HRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYD----------S 843 LP T+ E+ L + D LN++T+RF H ++ S Sbjct: 356 ---------LPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDISSDYTPTLNTDDAYASS 406 Query: 844 DRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALE----- 898 + +I ++ + + P G+ LL ++ YG+ I+IT +GI D + Sbjct: 407 ETTGSDGNEIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPIFITENGIADVEGDPEMPD 466 Query: 899 --DDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSD--- 948 DD R YL +++ V A + ++G++ + L + RFG D Sbjct: 467 PLDDWKRLDYLQRHISAVKDA-IDQGADVRGHFTWGLIDNFEWGSGYSSRFGLVYIDKED 525 Query: 949 ---FKAKSSIQFYNKV 961 K K S +++ K Sbjct: 526 GNKRKLKKSAKWFAKF 541 >3WQ4-A nrPDB Length = 507 Score = 561 bits (1447), Expect = e-160, Method: Composition-based stats. Identities = 152/476 (31%), Positives = 249/476 (52%), Gaps = 52/476 (10%) Query: 76 FLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIH---THLKNVSSTNGSSDSYI 132 F +FP F +G + A Q EG+ K+ GKGP+IWD F H + N S+ + + D Y Sbjct: 34 FNRTSFPDGFVFGAASSAYQFEGAAKEGGKGPNIWDTFTHEFPGKISNGSTGDVADDFYH 93 Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLLDALVLRNIEPIV 191 ++D+ L FIG+ ++ SISW R+ P G ++ N +G+ +Y+ +++ L+ + I+P + Sbjct: 94 RYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQPFI 153 Query: 192 TLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYG 251 T++HWDLP AL+++YGG+ + I++ F D+A CF+ FGDRVK+WIT++ P+ ++ GY Sbjct: 154 TIFHWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPWSYSYGGYD 213 Query: 252 TGMHAPGEK----------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLG 301 G+ APG + Y V HNL+ +H+ Y ++ +QKG + ITL Sbjct: 214 AGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQKGQIGITLV 273 Query: 302 SHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKH 361 ++W+ P S + D Q+++ + GWF P+ G+YP+ MR+ + LP F++ + Sbjct: 274 TYWMIP-YSNSKADKDAAQRALDFMYGWFIEPLSF-GEYPKSMRRLVGKRLPRFTKEQAM 331 Query: 362 EMRGTADFFAFSFGPNNFK---PLNTMAKMGQNV-------------------------- 392 ++G+ DF ++ N+ P + + Sbjct: 332 LVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTAFRNGVAIGRPTGVPAFFM 391 Query: 393 -SLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVLQAI 447 L++ L + K +YN+P I I ENG ++ V TE D +Y L + AI Sbjct: 392 YPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDPQRVYFYNQHLLSLKNAI 451 Query: 448 RLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 ++V GY W+ LD FEW YT R G+ YVDF K R PK SA ++K+ + Sbjct: 452 AA-GVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLK-RYPKHSALWFKKFL 505 Score = 480 bits (1237), Expect = e-135, Method: Composition-based stats. Identities = 130/492 (26%), Positives = 220/492 (44%), Gaps = 69/492 (14%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 + FP F +G S + E A +W+ + ++ T Sbjct: 36 RTSFPDGFVFGAASSAYQFEGAAKEGGKGP---NIWDTFTHEFPGKIS--NGSTGDVADD 90 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNL-SAVNRQALRYYRCVVSEGLKLGIS 636 + K+ +++L + + +R ++ WA VLP G L VN++ + +Y V+++ L GI Sbjct: 91 FYHRYKEDVKVLKFIGLDGFRMSISWARVLPRGKLSGGVNKEGIAFYNNVINDLLSKGIQ 150 Query: 637 AMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 +T++ H LP+ L G+L+P F+ +A LCF+E GD VK WIT+NEP Sbjct: 151 PFITIF-----HWDLPQALEDEYGGFLSPHIVNDFRDFAELCFKEFGDRVKHWITMNEPW 205 Query: 696 RLSDIYN--------------------RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQR 735 S SG + Y HNLL++HA A +LY +++ Q+ Sbjct: 206 SYSYGGYDAGLLAPGRCSAFMAFCPKGNSGTEPYIVTHNLLLSHAAAVKLYKEKYQAYQK 265 Query: 736 GAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHR 795 G + ++L W P + + + AA+R L F WF EPL G+YP +MR + + Sbjct: 266 GQIGITLVTYWMIPYS-NSKADKDAAQRALDFMYGWFIEPL-SFGEYPKSMRRLVGKR-- 321 Query: 796 RGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGS-----RYDSDRDIQFL 850 LPR T+ + L+KG+ DF LN++ +V++ + S DS + Sbjct: 322 -------LPRFTKEQAMLVKGSFDFLGLNYYIANYVLNVPTSNSVNLSYTTDSLSNQTAF 374 Query: 851 QDITRLSSPTRLA---VIPWGVRKLLRWVRRNYGDMDIYITASGIDD------QALEDDR 901 ++ + PT + + P G++ LL + + Y D IYIT +G+ D + D Sbjct: 375 RNGVAIGRPTGVPAFFMYPKGLKDLLVYTKEKYNDPVIYITENGMGDNNNVTTEEGIKDP 434 Query: 902 LRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------ 950 R Y+ ++L + A + V++KGY+ + + RFG DFK Sbjct: 435 QRVYFYNQHLLSLKNA-IAAGVKVKGYFTWAFLDNFEWLSGYTQRFGIVYVDFKDGLKRY 493 Query: 951 AKSSIQFYNKVI 962 K S ++ K + Sbjct: 494 PKHSALWFKKFL 505 >2CBU-A nrPDB Length = 468 Score = 556 bits (1432), Expect = e-158, Method: Composition-based stats. Identities = 156/452 (34%), Positives = 235/452 (51%), Gaps = 33/452 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT KN + + + D Y ++D+ Sbjct: 28 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 87 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ +GV Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ + I P VT+YHWDL Sbjct: 88 EIIEKLGVKAYRFSISWPRILPEGTGRV-NQKGLDFYNRIIDTLLEKGITPFVTIYHWDL 146 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ K GGW N I D F +Y+ F+ FGDRVK WIT++ P++VA G+ G+HAPG Sbjct: 147 PFALQLK-GGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAIVGHLYGVHAPG 205 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + A + HNL++AH++ + + G + I + + EP SE DI Sbjct: 206 MRDIYVA-FRAVHNLLRAHARAVKVFRETVK---DGKIGIVFNNGYFEP-ASEKEEDIRA 260 Query: 319 CQQSMVSVLG-WFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPN 377 + F NPI+ GDYPE + + LP + + E++ DF ++ Sbjct: 261 VRFMHQFNNYPLFLNPIY-RGDYPELVLEFAREYLPENYKDDMSEIQEKIDFVGLNYYSG 319 Query: 378 NFKPLNTMAK--------------MGQN-VSLNLREALNWIKLEYNNPRILIAENGWFTD 422 + + A MG V + L +K EYN P + I ENG D Sbjct: 320 HLVKFDPDAPAKVSFVERDLPKTAMGWEIVPEGIYWILKKVKEEYNPPEVYITENGAAFD 379 Query: 423 S----RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 + D I +K + Q +AI+ + + + GY WSLLD FEW + Y+ R G+ Sbjct: 380 DVVSEDGRVHDQNRIDYLKAHIGQAWKAIQ-EGVPLKGYFVWSLLDNFEWAEGYSKRFGI 438 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 YVD+++++ R K S ++Y +++ NG Sbjct: 439 VYVDYSTQK--RIVKDSGYWYSNVVKNNGLED 468 Score = 509 bits (1312), Expect = e-144, Method: Composition-based stats. Identities = 121/476 (25%), Positives = 209/476 (43%), Gaps = 60/476 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + E SP + +W+ + + G T C + Sbjct: 27 KFPEGFLWGVATASYQIEG---SPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 80 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ V YRF++ W +LP G VN++ L +Y ++ L+ GI+ V Sbjct: 81 NRWKEDIEIIEKLGVKAYRFSISWPRILPEGT-GRVNQKGLDFYNRIIDTLLEKGITPFV 139 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 T+Y H LP L GW N A+ F Y+ + F+ GD VK WIT+NEP ++ Sbjct: 140 TIY-----HWDLPFALQLKGGWANREIADWFAEYSRVLFENFGDRVKNWITLNEPWVVAI 194 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + + G G A HNLL AHA A +++ + G + + + + EPA Sbjct: 195 VGHLYGVHAPGMRDIYVAFRAVHNLLRAHARAVKVFRETVK---DGKIGIVFNNGYFEPA 251 Query: 751 NPYADSHWRAAERFLQFEIA-WFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + + RA QF F P+++ GDYP + E+ + LP + Sbjct: 252 SE-KEEDIRAVRFMHQFNNYPLFLNPIYR-GDYPELVLEF---------AREYLPENYKD 300 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 + ++ +DF LN+++ V + A ++ + + ++P G+ Sbjct: 301 DMSEIQEKIDFVGLNYYSGHLVKFDPDAPAKVS-------FVERDLPKTAMGWEIVPEGI 353 Query: 870 RKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLIDKV 923 +L+ V+ Y ++YIT +G DD ED D+ R YL ++ + KA + + V Sbjct: 354 YWILKKVKEEYNPPEVYITENGAAFDDVVSEDGRVHDQNRIDYLKAHIGQAWKA-IQEGV 412 Query: 924 RIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPF 969 +KGY+ + L + RFG D+ K S +Y+ V+ + G Sbjct: 413 PLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYSTQKRIVKDSGYWYSNVVKNNGLED 468 >3AHY-A nrPDB Length = 473 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 151/464 (32%), Positives = 223/464 (48%), Gaps = 43/464 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 PK+F WG T A Q+EG+ +DG+GPSIWD F K ++G + DSY +D+ Sbjct: 9 LPKDFQWGFATAAYQIEGAVDQDGRGPSIWDTFCAQPGKIADGSSGVTACDSYNRTAEDI 68 Query: 139 SALDFIGVSFYQFSISWPRLFPDG-IVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + L +G Y+FSISW R+ P+G N G+ +Y +D L+ I P +TL+HWD Sbjct: 69 ALLKSLGAKSYRFSISWSRIIPEGGRGDAVNQAGIDHYVKFVDDLLDAGITPFITLFHWD 128 Query: 198 LPLALQEKYGGWKND-TIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP L ++YGG N F +YA F+ +V+ WIT + P A GYG+G A Sbjct: 129 LPEGLHQRYGGLLNRTEFPLDFENYARVMFRAL-PKVRNWITFNEPLCSAIPGYGSGTFA 187 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH-QKGWLSITLGSHWIEPNRSENTMD 315 PG + + + +TVGHN++ AH + Y F+P G + I L + P + + D Sbjct: 188 PGRQ-STSEPWTVGHNILVAHGRAVKAYRDDFKPASGDGQIGIVLNGDFTYPWDAADPAD 246 Query: 316 IFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 ++ + WFA+PI+ GDYP MRK+L LP F+ E+ + G+ DF+ + Sbjct: 247 KEAAERRLEFFTAWFADPIYL-GDYPASMRKQLGDRLPTFTPEERALVHGSNDFYGMNHY 305 Query: 376 PNNFKPLN----------------------------TMAKMGQNVSLNLREALNWIKLEY 407 +N+ T + + + R+ L WI Y Sbjct: 306 TSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETQSPWLRPCAAGFRDFLVWISKRY 365 Query: 408 NNPRILIAENGWFTDSRVKT------EDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWS 461 P I + ENG ED + ++ ++ A+ LD + V GY AWS Sbjct: 366 GYPPIYVTENGTSIKGESDLPKEKILEDDFRVKYYNEYIRAMVTAVELDGVNVKGYFAWS 425 Query: 462 LLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 L+D FEW D Y R G+ YVD+ + QK R PK SA K + E Sbjct: 426 LMDNFEWADGYVTRFGVTYVDYENGQK-RFPKKSAKSLKPLFDE 468 Score = 477 bits (1227), Expect = e-134, Method: Composition-based stats. Identities = 127/474 (26%), Positives = 206/474 (43%), Gaps = 60/474 (12%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 P DF WG + + E +W+ + +G + C + Sbjct: 9 LPKDFQWGFATAAYQIEGAVDQDGRGPS---IWDTFCAQPGKIADG---SSGVTACDSYN 62 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAMV 639 + + +L + YRF++ W+ ++P G AVN+ + +Y V + L GI+ + Sbjct: 63 RTAEDIALLKSLGAKSYRFSISWSRIIPEGGRGDAVNQAGIDHYVKFVDDLLDAGITPFI 122 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPST--AEAFQAYAGLCFQELGDLVKLWITINEPNRL 697 TL+ H LPE L G L T F+ YA + F+ L V+ WIT NEP Sbjct: 123 TLF-----HWDLPEGLHQRYGGLLNRTEFPLDFENYARVMFRALP-KVRNWITFNEPLCS 176 Query: 698 SDIYNRSGN---------DTYGAAHNLLVAHALAWRLYDRQFRP-SQRGAVSLSLHADWA 747 + SG + + HN+LVAH A + Y F+P S G + + L+ D+ Sbjct: 177 AIPGYGSGTFAPGRQSTSEPWTVGHNILVAHGRAVKAYRDDFKPASGDGQIGIVLNGDFT 236 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT 807 P + + AAER L+F AWFA+P++ GDYPA+MR+ + + LP T Sbjct: 237 YPWDAADPADKEAAERRLEFFTAWFADPIY-LGDYPASMRKQLGDR---------LPTFT 286 Query: 808 EAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQD------ITRLSSPTR 861 ER L+ G+ DF +NH+T+ ++ H S D+ ++ L I + Sbjct: 287 PEERALVHGSNDFYGMNHYTSNYIRHRSSPASADDTVGNVDVLFTNKQGNCIGPETQSPW 346 Query: 862 LAVIPWGVRKLLRWVRRNYGDMDIYITASGID--------DQALEDDRLRKYYLGKYLQE 913 L G R L W+ + YG IY+T +G + + +D R Y +Y++ Sbjct: 347 LRPCAAGFRDFLVWISKRYGYPPIYVTENGTSIKGESDLPKEKILEDDFRVKYYNEYIRA 406 Query: 914 VLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------AKSSIQ 956 ++ A +D V +KGY+A+ L + RFG D++ K S + Sbjct: 407 MVTAVELDGVNVKGYFAWSLMDNFEWADGYVTRFGVTYVDYENGQKRFPKKSAK 460 >1V02-A nrPDB Length = 565 Score = 554 bits (1428), Expect = e-158, Method: Composition-based stats. Identities = 167/519 (32%), Positives = 247/519 (47%), Gaps = 61/519 (11%) Query: 48 RAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGP 107 R+ F + I S++ ++ ++ D FP +F +G T A Q+EG+W +DGKGP Sbjct: 43 RSNLSFRPRAQTISSESAGIHRLSPWEIPRRDWFPPSFLFGAATSAYQIEGAWNEDGKGP 102 Query: 108 SIWDHFIHTHLK---NVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIV 164 S WDHF H + + S+ + ++DSY +D+ L +G+ Y+FSISWPR+ P G + Sbjct: 103 STWDHFCHNFPEWIVDRSNGDVAADSYHMYAEDVRLLKEMGMDAYRFSISWPRILPKGTL 162 Query: 165 TVA-NAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYAT 223 N K ++YY+ L+D L+ IEP +T++HWD P AL + YGG+ ++ II + D+A Sbjct: 163 AGGINEKRVEYYNKLIDLLLENGIEPYITIFHWDTPQALVDAYGGFLDERIIKDYTDFAK 222 Query: 224 YCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGN-----------LAAVYTVGHN 272 CF+ FG VK W+T + P YGTG+ APG L+ Y V HN Sbjct: 223 VCFEKFGKTVKNWLTFNEPETFCSVSYGTGVLAPGRCSPGVSCAVPTGNSLSEPYIVAHN 282 Query: 273 LIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFAN 332 L++AH++ YN + G + + L P + +D ++SM LGWF Sbjct: 283 LLRAHAETVDIYN-KYHKGADGRIGLALNVFGRVP-YTNTFLDQQAQERSMDKCLGWFLE 340 Query: 333 PIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG-----------PNNFKP 381 P+ GDYP MR +P F E E+ ++ G+ D ++ PNN Sbjct: 341 PV-VRGDYPFSMRVSARDRVPYFKEKEQEKLVGSYDMIGINYYTSTFSKHIDLSPNNSPV 399 Query: 382 LNTMAKMGQNV---------------------SLNLREALNWIKLEYNNPRILIAENGWF 420 LNT L + L +K +Y NP + I ENG Sbjct: 400 LNTDDAYASQETKGPDGNAIGPPTGNAWINMYPKGLHDILMTMKNKYGNPPMYITENGMG 459 Query: 421 TDSRVKT------EDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTI 474 + ED T + ++ LS + Q+I L V GY AWSLLD FEW YT Sbjct: 460 DIDKGDLPKPVALEDHTRLDYIQRHLSVLKQSIDL-GADVRGYFAWSLLDNFEWSSGYTE 518 Query: 475 RRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKES 513 R G+ YVD + ER K SA + ++ NG + K Sbjct: 519 RFGIVYVDRENGC-ERTMKRSARWLQEF---NGAAKKVE 553 Score = 463 bits (1191), Expect = e-130, Method: Composition-based stats. Identities = 113/528 (21%), Positives = 205/528 (38%), Gaps = 78/528 (14%) Query: 489 ERKPKSSAHYYKQIIRENGFSLKESTP---DVQGQFPCDFSWGVTESVLKPESVASSPQF 545 +R+ S Q I + +P + FP F +G S + E + Sbjct: 41 KRRSNLSFRPRAQTISSESAGIHRLSPWEIPRRDWFPPSFLFGAATSAYQIEGAWNEDGK 100 Query: 546 SDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWAS 605 W+ + + V + + + +L M + YRF++ W Sbjct: 101 GPS---TWDHFCHNFPEWI--VDRSNGDVAADSYHMYAEDVRLLKEMGMDAYRFSISWPR 155 Query: 606 VLPTGNL-SAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLH-ADGWLN 663 +LP G L +N + + YY ++ L+ GI +T++ H P+ L+ G+L+ Sbjct: 156 ILPKGTLAGGINEKRVEYYNKLIDLLLENGIEPYITIF-----HWDTPQALVDAYGGFLD 210 Query: 664 PSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSG------------------ 705 + + +A +CF++ G VK W+T NEP + +G Sbjct: 211 ERIIKDYTDFAKVCFEKFGKTVKNWLTFNEPETFCSVSYGTGVLAPGRCSPGVSCAVPTG 270 Query: 706 ---NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAE 762 ++ Y AHNLL AHA +Y+ ++ G + L+L+ P +A E Sbjct: 271 NSLSEPYIVAHNLLRAHAETVDIYN-KYHKGADGRIGLALNVFGRVP-YTNTFLDQQAQE 328 Query: 763 RFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCA 822 R + + WF EP+ + GDYP +MR + +P E E+ L G+ D Sbjct: 329 RSMDKCLGWFLEPVVR-GDYPFSMR---------VSARDRVPYFKEKEQEKLVGSYDMIG 378 Query: 823 LNHFTTRFVMHEQLAGSRYD----------SDRDIQFLQDITRLSSPTRLAVIPWGVRKL 872 +N++T+ F H L+ + + I + + + P G+ + Sbjct: 379 INYYTSTFSKHIDLSPNNSPVLNTDDAYASQETKGPDGNAIGPPTGNAWINMYPKGLHDI 438 Query: 873 LRWVRRNYGDMDIYITASGIDD--------QALEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 L ++ YG+ +YIT +G+ D +D R Y+ ++L VLK + Sbjct: 439 LMTMKNKYGNPPMYITENGMGDIDKGDLPKPVALEDHTRLDYIQRHL-SVLKQSIDLGAD 497 Query: 925 IKGYYAFKLAEE-----KSKPRFGFFTSDFKA------KSSIQFYNKV 961 ++GY+A+ L + RFG D + K S ++ + Sbjct: 498 VRGYFAWSLLDNFEWSSGYTERFGIVYVDRENGCERTMKRSARWLQEF 545 >2RGL-A nrPDB Length = 481 Score = 550 bits (1418), Expect = e-156, Method: Composition-based stats. Identities = 160/485 (32%), Positives = 253/485 (52%), Gaps = 50/485 (10%) Query: 65 PNFTPVNES-QLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS 123 + P FPK F +G T A QVEG G+GPSIWD F HT + Sbjct: 3 ADVVPKPNWLGGLSRAAFPKRFVFGTVTSAYQVEGMAASGGRGPSIWDAFAHTPGNVAGN 62 Query: 124 --TNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDA 181 + ++D Y ++D++ + + Y+FSISW R+FPDG V N +G+ YY+ L++ Sbjct: 63 QNGDVATDQYHRYKEDVNLMKSLNFDAYRFSISWSRIFPDGEGRV-NQEGVAYYNNLINY 121 Query: 182 LVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 L+ + I P V LYH+DLPLAL++KYGGW N + D+F +YA +CF+ FG+RVK+W T + Sbjct: 122 LLQKGITPYVNLYHYDLPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNE 181 Query: 242 PYLVAWHGYGTGMHAPGEKGNLAA-------VYTVGHNLIKAHSKVWHNYNTHFRPHQKG 294 P +VA GY G + P AA Y V HN + +H+ Y T ++ Q+G Sbjct: 182 PRIVALLGYDQGTNPPKRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQG 241 Query: 295 WLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPI 354 + I L +W E S +T D Q++ +GW+ +P+ +G YP+ M+ + LP Sbjct: 242 KVGIVLDFNWYE-ALSNSTEDQAAAQRARDFHIGWYLDPLI-NGHYPQIMQDLVKDRLPK 299 Query: 355 FSEAEKHEMRGTADFFAFSFGPNNF----------------------------KPLNTMA 386 F+ + ++G+AD+ + ++ KP+ A Sbjct: 300 FTPEQARLVKGSADYIGINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNGKPIGPQA 359 Query: 387 KMGQ--NVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFL 440 V + +N+IK +Y NP ++I ENG + + + DTT ++ +++L Sbjct: 360 NSNWLYIVPWGMYGCVNYIKQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVHFYRSYL 419 Query: 441 SQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYK 500 +Q+ +AI + V GY AWSLLD FEW YT + G+ YVDFN+ ER PK+SA++++ Sbjct: 420 TQLKKAID-EGANVAGYFAWSLLDNFEWLSGYTSKFGIVYVDFNT--LERHPKASAYWFR 476 Query: 501 QIIRE 505 +++ Sbjct: 477 DMLKH 481 Score = 480 bits (1235), Expect = e-135, Method: Composition-based stats. Identities = 119/489 (24%), Positives = 218/489 (44%), Gaps = 66/489 (13%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 + FP F +G S + E +A+S +W+A + + + Sbjct: 17 RAAFPKRFVFGTVTSAYQVEGMAASGGRGPS---IWDAFAHTPGNVAGN---QNGDVATD 70 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637 + K+ + ++ + YRF++ W+ + P G VN++ + YY +++ L+ GI+ Sbjct: 71 QYHRYKEDVNLMKSLNFDAYRFSISWSRIFPDGE-GRVNQEGVAYYNNLINYLLQKGITP 129 Query: 638 MVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 V LY H LP L GWLN A+ F YA CF+ G+ VK W T NEP Sbjct: 130 YVNLY-----HYDLPLALEKKYGGWLNAKMADLFTEYADFCFKTFGNRVKHWFTFNEPRI 184 Query: 697 LSDIYNRSG-----------------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 ++ + G + Y AHN L++HA A Y +++ +Q+G V Sbjct: 185 VALLGYDQGTNPPKRCTKCAAGGNSATEPYIVAHNFLLSHAAAVARYRTKYQAAQQGKVG 244 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 + L +W E + + AA+R F I W+ +PL G YP M++ + + Sbjct: 245 IVLDFNWYEALSNSTE-DQAAAQRARDFHIGWYLDPLI-NGHYPQIMQDLVKDR------ 296 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQL---AGSRYDSDRDIQFL-----Q 851 LP+ T + RL+KG+ D+ +N +T ++ +QL + Y +D + ++ + Sbjct: 297 ---LPKFTPEQARLVKGSADYIGINQYTASYMKGQQLMQQTPTSYSADWQVTYVFAKNGK 353 Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQA------LEDDRLRKY 905 I ++ L ++PWG+ + ++++ YG+ + IT +G+D A D R + Sbjct: 354 PIGPQANSNWLYIVPWGMYGCVNYIKQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVH 413 Query: 906 YLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSI 955 + YL ++ KA + + + GY+A+ L + +FG DF K+S Sbjct: 414 FYRSYLTQLKKA-IDEGANVAGYFAWSLLDNFEWLSGYTSKFGIVYVDFNTLERHPKASA 472 Query: 956 QFYNKVISS 964 ++ ++ Sbjct: 473 YWFRDMLKH 481 >4MDP-A nrPDB Length = 499 Score = 550 bits (1417), Expect = e-156, Method: Composition-based stats. Identities = 154/483 (31%), Positives = 227/483 (46%), Gaps = 50/483 (10%) Query: 70 VNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGS 127 V + P +F WG T A Q+EGS +DG+GPSIWD F K + SS + Sbjct: 15 VPRGSHMASMSLPPDFKWGFATAAYQIEGSVNEDGRGPSIWDTFCAIPGKIADGSSGAVA 74 Query: 128 SDSYIFLEKDLSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRN 186 DSY ++D++ L +G + Y+FSISW R+ P G N KG+ +Y +D L+ Sbjct: 75 CDSYKRTKEDIALLKELGANSYRFSISWSRIIPLGGRNDPINQKGIDHYVKFVDDLIEAG 134 Query: 187 IEPIVTLYHWDLPLALQEKYGGWKN-DTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLV 245 I P +TL+HWDLP AL ++YGG+ N + F +YA F+ + K+WIT + P+ Sbjct: 135 ITPFITLFHWDLPDALDKRYGGFLNKEEFAADFENYARIMFKAI-PKCKHWITFNEPWCS 193 Query: 246 AWHGYGTGMHAPGEK---------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWL 296 A GY TG APG + + VGHN++ AH++ Y F+P Q G + Sbjct: 194 AILGYNTGYFAPGHTSDRSKSPVGDSAREPWIVGHNILIAHARAVKAYREDFKPTQGGEI 253 Query: 297 SITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFS 356 ITL P E+ DI C + + + WFA+PI+ G YP+ MRK+L LP F+ Sbjct: 254 GITLNGDATLPWDPEDPADIEACDRKIEFAISWFADPIYF-GKYPDSMRKQLGDRLPEFT 312 Query: 357 EAEKHEMRGTADFFAFSFGPNNFKPLNTMAK----------------------------M 388 E ++G+ DF+ + N+ T Sbjct: 313 PEEVALVKGSNDFYGMNHYTANYIKHKTGVPPEDDFLGNLETLFYNKYGDCIGPETQSFW 372 Query: 389 GQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVK------TEDTTAIYMMKNFLSQ 442 + + R+ LNW+ Y P+I + ENG ED + +++ Sbjct: 373 LRPHAQGFRDLLNWLSKRYGYPKIYVTENGTSLKGENDMPLEQVLEDDFRVKYFNDYVRA 432 Query: 443 VLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI 502 + A+ D V GY AWSLLD FEW + Y R G+ YVD+ + ++R PK SA K + Sbjct: 433 MAAAVAEDGCNVRGYLAWSLLDNFEWAEGYETRFGVTYVDYAN-DQKRYPKKSAKSLKPL 491 Query: 503 IRE 505 Sbjct: 492 FDS 494 Score = 473 bits (1217), Expect = e-133, Method: Composition-based stats. Identities = 121/485 (24%), Positives = 209/485 (43%), Gaps = 71/485 (14%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 P DF WG + + E + +W+ +G + C + Sbjct: 25 SLPPDFKWGFATAAYQIEGSVNEDGRGPS---IWDTFCAIPGKIADG---SSGAVACDSY 78 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAM 638 K+ + +L + YRF++ W+ ++P G + +N++ + +Y V + ++ GI+ Sbjct: 79 KRTKEDIALLKELGANSYRFSISWSRIIPLGGRNDPINQKGIDHYVKFVDDLIEAGITPF 138 Query: 639 VTLYYPTHAHLGLPEPL-LHADGWLNPST-AEAFQAYAGLCFQELGDLVKLWITINEPNR 696 +TL+ H LP+ L G+LN A F+ YA + F+ + K WIT NEP Sbjct: 139 ITLF-----HWDLPDALDKRYGGFLNKEEFAADFENYARIMFKAIP-KCKHWITFNEPWC 192 Query: 697 LSDIYNRSG-------------------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGA 737 + + +G + + HN+L+AHA A + Y F+P+Q G Sbjct: 193 SAILGYNTGYFAPGHTSDRSKSPVGDSAREPWIVGHNILIAHARAVKAYREDFKPTQGGE 252 Query: 738 VSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRG 797 + ++L+ D P +P + A +R ++F I+WFA+P++ G YP +MR+ + + Sbjct: 253 IGITLNGDATLPWDPEDPADIEACDRKIEFAISWFADPIY-FGKYPDSMRKQLGDR---- 307 Query: 798 LSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL------Q 851 LP T E L+KG+ DF +NH+T ++ H+ D +++ L Sbjct: 308 -----LPEFTPEEVALVKGSNDFYGMNHYTANYIKHKTGVPPEDDFLGNLETLFYNKYGD 362 Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID---------DQALEDDRL 902 I + L G R LL W+ + YG IY+T +G +Q LEDD Sbjct: 363 CIGPETQSFWLRPHAQGFRDLLNWLSKRYGYPKIYVTENGTSLKGENDMPLEQVLEDD-F 421 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------A 951 R Y Y++ + A D ++GY A+ L + + RFG D+ Sbjct: 422 RVKYFNDYVRAMAAAVAEDGCNVRGYLAWSLLDNFEWAEGYETRFGVTYVDYANDQKRYP 481 Query: 952 KSSIQ 956 K S + Sbjct: 482 KKSAK 486 >3PTM-A nrPDB Length = 505 Score = 550 bits (1417), Expect = e-156, Method: Composition-based stats. Identities = 162/501 (32%), Positives = 253/501 (50%), Gaps = 60/501 (11%) Query: 54 SGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHF 113 +G A ++ N P +FPK F +G + + Q EG + G+GPSIWD F Sbjct: 12 AGSAAAPFAYNSAGEP-----PVSRRSFPKGFIFGTASSSYQYEGGAAEGGRGPSIWDTF 66 Query: 114 IHTHLKNV---SSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGI-VTVANA 169 H H + + S+ + +SDSY ++D+ + +G+ Y+FSISW R+ P+G N Sbjct: 67 THQHPEKIADRSNGDVASDSYHLYKEDVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNK 126 Query: 170 KGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMF 229 +G++YY+ L++ L+ + ++P +TL+HWD P AL++KY G+ + II+ F DYA CF+ F Sbjct: 127 EGIKYYNNLINELLSKGVQPFITLFHWDSPQALEDKYNGFLSPNIINDFKDYAEICFKEF 186 Query: 230 GDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLA-----------AVYTVGHNLIKAHS 278 GDRVK WIT + P+ +GY TG+ APG YT H+ + AH+ Sbjct: 187 GDRVKNWITFNEPWTFCSNGYATGLFAPGRCSPWEKGNCSVGDSGREPYTACHHQLLAHA 246 Query: 279 KVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDG 338 + Y ++ QKG + ITL SHW P S + + ++++ + GWF +P+ G Sbjct: 247 ETVRLYKAKYQALQKGKIGITLVSHWFVPF-SRSKSNNDAAKRAIDFMFGWFMDPLI-RG 304 Query: 339 DYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFK------------------ 380 DYP MR + + LP F++ + ++G DF ++ N+ Sbjct: 305 DYPLSMRGLVGNRLPQFTKEQSKLVKGAFDFIGLNYYTANYADNLPPSNGLNNSYTTDSR 364 Query: 381 ----------PLNTMAKMGQ--NVSLNLREALNWIKLEYNNPRILIAENGWFTDS----- 423 P+ A R+ L ++K Y NP + I ENG + Sbjct: 365 ANLTGVRNGIPIGPQAASPWLYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLP 424 Query: 424 -RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVD 482 + +D I L +L AIR D V GY AWSLLD FEW + YT+R G+ +VD Sbjct: 425 LQEALKDDARIEYYHKHLLSLLSAIR-DGANVKGYFAWSLLDNFEWSNGYTVRFGINFVD 483 Query: 483 FNSKQKERKPKSSAHYYKQII 503 +N +K R PK+SAH++K+ + Sbjct: 484 YNDGRK-RYPKNSAHWFKKFL 503 Score = 483 bits (1243), Expect = e-136, Method: Composition-based stats. Identities = 133/500 (26%), Positives = 227/500 (45%), Gaps = 72/500 (14%) Query: 513 STPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTR 572 P + FP F +G S + E A+ +W+ ++ ++ Sbjct: 26 EPPVSRRSFPKGFIFGTASSSYQYEGGAAEGGRGPS---IWDTFTHQHPEKI--ADRSNG 80 Query: 573 PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNL-SAVNRQALRYYRCVVSEGL 631 + K+ + ++ M + YRF++ W +LP G+L VN++ ++YY +++E L Sbjct: 81 DVASDSYHLYKEDVRLMKDMGMDAYRFSISWTRILPNGSLRGGVNKEGIKYYNNLINELL 140 Query: 632 KLGISAMVTLYYPTHAHLGLPEPLLHAD-GWLNPSTAEAFQAYAGLCFQELGDLVKLWIT 690 G+ +TL+ H P+ L G+L+P+ F+ YA +CF+E GD VK WIT Sbjct: 141 SKGVQPFITLF-----HWDSPQALEDKYNGFLSPNIINDFKDYAEICFKEFGDRVKNWIT 195 Query: 691 INEPNRLSDIYNR---------------------SGNDTYGAAHNLLVAHALAWRLYDRQ 729 NEP SG + Y A H+ L+AHA RLY + Sbjct: 196 FNEPWTFCSNGYATGLFAPGRCSPWEKGNCSVGDSGREPYTACHHQLLAHAETVRLYKAK 255 Query: 730 FRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREY 789 ++ Q+G + ++L + W P + + S+ AA+R + F WF +PL + GDYP +MR Sbjct: 256 YQALQKGKIGITLVSHWFVPFS-RSKSNNDAAKRAIDFMFGWFMDPLIR-GDYPLSMRGL 313 Query: 790 IASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAG-----SRYDSD 844 + ++ LP+ T+ + +L+KG DF LN++T + + + DS Sbjct: 314 VGNR---------LPQFTKEQSKLVKGAFDFIGLNYYTANYADNLPPSNGLNNSYTTDSR 364 Query: 845 RDIQFLQ---DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD------- 894 ++ ++ I ++ L V P G R LL +V+ NYG+ +YIT +G+D+ Sbjct: 365 ANLTGVRNGIPIGPQAASPWLYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLP 424 Query: 895 -QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSD 948 Q D R Y K+L +L A + D +KGY+A+ L + RFG D Sbjct: 425 LQEALKDDARIEYYHKHLLSLLSA-IRDGANVKGYFAWSLLDNFEWSNGYTVRFGINFVD 483 Query: 949 FK------AKSSIQFYNKVI 962 + K+S ++ K + Sbjct: 484 YNDGRKRYPKNSAHWFKKFL 503 >5BWF-A nrPDB Length = 485 Score = 549 bits (1415), Expect = e-156, Method: Composition-based stats. Identities = 153/463 (33%), Positives = 219/463 (47%), Gaps = 42/463 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG--SSDSYIFLEKDL 138 PK+F WG T A Q+EG+ KDG+GPSIWD F K T+G + DSY +D+ Sbjct: 22 LPKDFQWGFATAAYQIEGAIDKDGRGPSIWDTFCAIPGKIADGTSGVTACDSYNRTAEDI 81 Query: 139 SALDFIGVSFYQFSISWPRLFPDG-IVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + L +G Y+FSISW R+ P G N G+ +Y+ +D L+ I P +TL+HWD Sbjct: 82 ALLKSLGAKSYRFSISWSRIIPKGGRDDPVNQLGIDHYAQFVDDLLEAGITPFITLFHWD 141 Query: 198 LPLALQEKYGGWKND-TIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP L ++YGG N F +YA F+ +V+ WIT + P A GYG+G A Sbjct: 142 LPEELHQRYGGLLNRTEFPLDFENYARVMFKAL-PKVRNWITFNEPLCSAIPGYGSGTFA 200 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG + + + VGHNL+ AH + Y F+ G + I L + P S + +D Sbjct: 201 PGRQ-STTEPWIVGHNLLVAHGRAVKVYRDEFKDLNDGQIGIVLNGDFTYPWDSSDPLDR 259 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 ++ + W+A+PI+ GDYP MRK+L LP F+ EK + G+ DF+ + Sbjct: 260 EAAERRLEFFTAWYADPIYL-GDYPASMRKQLGDRLPEFTPEEKAFVLGSNDFYGMNHYT 318 Query: 377 NNFKPLNTMAK----------------------------MGQNVSLNLREALNWIKLEYN 408 +N+ T + R+ L WI YN Sbjct: 319 SNYIRHRTSPATADDTVGNVDVLFYNKEGQCIGPETESSWLRPCPAGFRDFLVWISKRYN 378 Query: 409 NPRILIAENGWFTDSRVKT------EDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSL 462 P+I + ENG ED + ++ + A LD + V GY AWSL Sbjct: 379 YPKIYVTENGTSLKGENDLPKEKILEDDFRVNYYNEYIRAMFTAATLDGVNVKGYFAWSL 438 Query: 463 LDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 +D FEW D Y R G+ YVD+ + Q+ R PK SA K + E Sbjct: 439 MDNFEWADGYVTRFGVTYVDYENGQQ-RFPKKSAKSLKPLFDE 480 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 124/480 (25%), Positives = 205/480 (42%), Gaps = 59/480 (12%) Query: 514 TPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRP 573 P P DF WG + + E +W+ +G T Sbjct: 15 VPRGSHMLPKDFQWGFATAAYQIEGAIDKDGRGPS---IWDTFCAIPGKIADGTSGVT-- 69 Query: 574 AQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLK 632 C + + + +L + YRF++ W+ ++P G VN+ + +Y V + L+ Sbjct: 70 -ACDSYNRTAEDIALLKSLGAKSYRFSISWSRIIPKGGRDDPVNQLGIDHYAQFVDDLLE 128 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPST--AEAFQAYAGLCFQELGDLVKLWIT 690 GI+ +TL+ H LPE L G L T F+ YA + F+ L V+ WIT Sbjct: 129 AGITPFITLF-----HWDLPEELHQRYGGLLNRTEFPLDFENYARVMFKALP-KVRNWIT 182 Query: 691 INEPNRLSDIYNRSGN---------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLS 741 NEP + SG + + HNLLVAH A ++Y +F+ G + + Sbjct: 183 FNEPLCSAIPGYGSGTFAPGRQSTTEPWIVGHNLLVAHGRAVKVYRDEFKDLNDGQIGIV 242 Query: 742 LHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSS 801 L+ D+ P + AAER L+F AW+A+P++ GDYPA+MR+ + + Sbjct: 243 LNGDFTYPWDSSDPLDREAAERRLEFFTAWYADPIY-LGDYPASMRKQLGDR-------- 293 Query: 802 ALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFL------QDITR 855 LP T E+ + G+ DF +NH+T+ ++ H + D+ ++ L Q I Sbjct: 294 -LPEFTPEEKAFVLGSNDFYGMNHYTSNYIRHRTSPATADDTVGNVDVLFYNKEGQCIGP 352 Query: 856 LSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID--------DQALEDDRLRKYYL 907 + + L P G R L W+ + Y IY+T +G + + +D R Y Sbjct: 353 ETESSWLRPCPAGFRDFLVWISKRYNYPKIYVTENGTSLKGENDLPKEKILEDDFRVNYY 412 Query: 908 GKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------AKSSIQ 956 +Y++ + A +D V +KGY+A+ L + RFG D++ K S + Sbjct: 413 NEYIRAMFTAATLDGVNVKGYFAWSLMDNFEWADGYVTRFGVTYVDYENGQQRFPKKSAK 472 >3VKK-A nrPDB Length = 469 Score = 549 bits (1415), Expect = e-156, Method: Composition-based stats. Identities = 176/467 (37%), Positives = 250/467 (53%), Gaps = 37/467 (7%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNGSSDSYIFLEK 136 FP F W T A QVEG W DGKGP +WD F H + V + + + SY E+ Sbjct: 2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEE 61 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 DL + +G++ Y+FS+SW RL PDG N KG+ YY+ ++D L+ + PIVTLYH+ Sbjct: 62 DLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHF 121 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP L+++ GGW ++ II+ F+ YA +CF FGDRVK WITI+ +++ Y GM Sbjct: 122 DLPQTLEDQ-GGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINQANVLSVMSYDLGMFP 180 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG Y HNLIKAH++ WH+Y++ FR QKG +S++L + W+EP + D Sbjct: 181 PGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQ 240 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGT 366 ++++ L FA PI DGDYPE ++ ++ S LP F+E EK ++GT Sbjct: 241 EAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGT 300 Query: 367 ADFFAFSFGPNNFKPL--NTMAKMG---------------------QNVSLNLREALNWI 403 ADFFA + N ++G V + + L +I Sbjct: 301 ADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYI 360 Query: 404 KLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL 463 K YNNP I I ENG+ +DT + ++ +AI+LD++ + Y AWSLL Sbjct: 361 KDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLL 420 Query: 464 DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 D FEW Y+ R GLF+VDF + R P +SA Y +IIR NG Sbjct: 421 DNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLEA 467 Score = 503 bits (1295), Expect = e-142, Method: Composition-based stats. Identities = 163/476 (34%), Positives = 247/476 (51%), Gaps = 38/476 (7%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F W + + E + VW+ ++ RV + +T C + Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGP---CVWDTFTHQGGERV--FKNQTGDVACGSYT 57 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ L+ + ++ +THYRF+L W+ +LP G +N++ + YY ++ + LK G++ +VT Sbjct: 58 LWEEDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVT 117 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GWL+ + E+F YA CF GD VK WITIN+ N LS + Sbjct: 118 LY-----HFDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINQANVLSVM 172 Query: 701 YNRS----------GNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 G Y AAHNL+ AHA +W YD FR Q+G VSLSL A W EPA Sbjct: 173 SYDLGMFPPGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPA 232 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIAS-KHRRGLSSSALPRLTEA 809 +P + S AA+R + F + FA+P+F GDYP ++ IAS ++G SS LP TE Sbjct: 233 DPNSVSDQEAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEE 292 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYD--SDRDIQFLQDITRLSSPTRLAVIPW 867 E++++KGT DF A+ ++TTR + +++ D +I+F D + + + V+PW Sbjct: 293 EKKMIKGTADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSW-KNVDWIYVVPW 351 Query: 868 GVRKLLRWVRRNYGDMDIYITASGI--DDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRI 925 GV KLL++++ Y + IYIT +G D A DD R Y + QE+ KA +DKV + Sbjct: 352 GVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNL 411 Query: 926 KGYYAFKLAEE-----KSKPRFGFFTSDFK-------AKSSIQFYNKVISSRGFPF 969 + Y A+ L + RFG F DF+ +S + Y K+I + G Sbjct: 412 QVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLEA 467 >3AHX-A nrPDB Length = 453 Score = 546 bits (1408), Expect = e-155, Method: Composition-based stats. Identities = 150/453 (33%), Positives = 225/453 (49%), Gaps = 35/453 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVS--STNGSSDSYIFLEKDL 138 FPK+F +G T A Q+EG++K+D KG SIWD F H + + + D Y ++D+ Sbjct: 6 FPKDFIFGTATAAYQIEGAYKEDEKGESIWDRFSHIPGNVAKMHNGDIACDHYHRYKEDV 65 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +G+ Y+FSI+WPR+FP G + N KG+Q+Y L+D L+ +IEP +T+YHWDL Sbjct: 66 QLLKSLGIKSYRFSIAWPRIFPKGFGEI-NQKGIQFYRDLIDELIKNDIEPAITIYHWDL 124 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P LQ+ GGW N + D + DYA F+ FGDRVK WIT + P++ ++ GY G+HAPG Sbjct: 125 PQKLQD-IGGWANPQVADYYVDYANLLFREFGDRVKTWITHNEPWVASYLGYALGVHAPG 183 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K ++ HN++ +H K Y Q G + ITL + S + DI Sbjct: 184 IK-DMKMALLAAHNILLSHFKAVKAYREL---EQDGQIGITLNLSTCY-SNSADEEDIAA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS--VLPIFSEAEKHEMRGTADFFAFSFGP 376 +S WF + G YPE M K ++P + E+ T+DF ++ Sbjct: 239 AHRSDGWNNRWFLDAAL-KGTYPEDMIKIFSDTNIMPELPKELFTEVFETSDFLGINYYT 297 Query: 377 NNFKP--------------LNTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFT 421 N +MG + L + L I +Y N + I ENG Sbjct: 298 RQVVKNNSEAFIGAESVAMDNPKTEMGWEIYPQGLYDLLTRIHRDYGNIDLYITENGAAF 357 Query: 422 DSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRG 477 + V K ED + + + L AI + + GY WS +D FEW + Y R G Sbjct: 358 NDMVNRDGKVEDENRLDYLYTHFAAALSAIEA-GVPLKGYYIWSFMDNFEWAEGYEKRFG 416 Query: 478 LFYVDFNSKQKERKPKSSAHYYKQII-RENGFS 509 + +V++ + +ER K SA++YK++I R N Sbjct: 417 IVHVNYKT--QERTIKKSAYWYKELIERSNKLE 447 Score = 487 bits (1254), Expect = e-137, Method: Composition-based stats. Identities = 115/475 (24%), Positives = 201/475 (42%), Gaps = 58/475 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP DF +G + + E + + +W+ + + ++ C + Sbjct: 5 RFPKDFIFGTATAAYQIEGAYKEDEKGES---IWDRFSHIPGNVA---KMHNGDIACDHY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +++L + + YRF++ W + P G +N++ +++YR ++ E +K I + Sbjct: 59 HRYKEDVQLLKSLGIKSYRFSIAWPRIFPKG-FGEINQKGIQFYRDLIDELIKNDIEPAI 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 T+Y H LP+ L GW NP A+ + YA L F+E GD VK WIT NEP S Sbjct: 118 TIY-----HWDLPQKLQDIGGWANPQVADYYVDYANLLFREFGDRVKTWITHNEPWVASY 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + G G AAHN+L++H A + Y Q G + ++L+ Sbjct: 173 LGYALGVHAPGIKDMKMALLAAHNILLSHFKAVKAYREL---EQDGQIGITLNLSTCYS- 228 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 N + AA R + WF + K G YP M + + ++ +P L + Sbjct: 229 NSADEEDIAAAHRSDGWNNRWFLDAALK-GTYPEDMIKIFSD-------TNIMPELPKEL 280 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 + T DF +N++T + V + A +S + + + P G+ Sbjct: 281 FTEVFETSDFLGINYYTRQVVKNNSEAFIGAESVA-------MDNPKTEMGWEIYPQGLY 333 Query: 871 KLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 LL + R+YG++D+YIT +G ++ +D R YL + L A + V Sbjct: 334 DLLTRIHRDYGNIDLYITENGAAFNDMVNRDGKVEDENRLDYLYTHFAAALSA-IEAGVP 392 Query: 925 IKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVI-SSRGFP 968 +KGYY + + + RFG ++K K S +Y ++I S Sbjct: 393 LKGYYIWSFMDNFEWAEGYEKRFGIVHVNYKTQERTIKKSAYWYKELIERSNKLE 447 >5JBO-A nrPDB Length = 485 Score = 546 bits (1408), Expect = e-155, Method: Composition-based stats. Identities = 158/475 (33%), Positives = 229/475 (48%), Gaps = 51/475 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKD 137 + PK+F WG T A Q+EG+ K+ G+GPSIWD + H N ++ + + D Y ++D Sbjct: 7 SLPKDFEWGFATAAYQIEGAVKEGGRGPSIWDTYCHLEPSRTNGANGDVACDHYHRYDED 66 Query: 138 LSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 L G Y+FS+SW R+ P G + N +G+Q+YS L+DAL+ R + P VTLYHW Sbjct: 67 FDLLTKYGAKAYRFSLSWSRIIPLGGRLDPINEEGIQFYSNLIDALLKRGVTPWVTLYHW 126 Query: 197 DLPLALQEKYGGWKNDTIID-IFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMH 255 DLP AL ++YGGW N + F YA CF+ FGDRVK WITI+ P++ + +GY TG + Sbjct: 127 DLPQALHDRYGGWLNVKEVQLDFERYARLCFERFGDRVKNWITINEPWIQSIYGYATGSN 186 Query: 256 APGE---------KGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIE 306 APG + G I +H++ Y+ FR QKG + I+L + E Sbjct: 187 APGRSSINKHSTEGDTTTEPWLAGKAQIMSHARAVAVYSKDFRASQKGQIGISLNGDYYE 246 Query: 307 PNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEM-RG 365 P S + D ++ M +GW+ANPI DYP MRK+L LP + A+ + G Sbjct: 247 PWDSSDPRDKEAAERRMEFHIGWYANPIFLKKDYPASMRKQLGDRLPALTPADFAILNAG 306 Query: 366 TADFFAFSFGPNNF--------------------------KPLNTMAKMGQ--NVSLNLR 397 DF+ ++ + F P+ + + + R Sbjct: 307 ETDFYGMNYYTSQFARHYEGPVPKTDFLGAIHEHQENKDGSPVGEESGIFWLRSCPDMFR 366 Query: 398 EALNWIKLEYNNPRILIAENGWFTDSRVK------TEDTTAIYMMKNFLSQVLQAIRLDE 451 + L + Y P I I ENG K D I + L + +AI D Sbjct: 367 KHLARVHGLYGKP-IYITENGCPCPGEDKMTCEEAINDPFRIQYFDSHLDSISKAISQDG 425 Query: 452 IRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 + V GY AW+LLD EW D Y R G+ Y D+ + +R PK SA K + + Sbjct: 426 VVVKGYFAWALLDNLEWSDGYGPRFGVTYTDYTT--LKRTPKKSALVLKDMFADR 478 Score = 470 bits (1209), Expect = e-132, Method: Composition-based stats. Identities = 138/493 (27%), Positives = 211/493 (42%), Gaps = 68/493 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 P DF WG + + E +W+ + R G C + Sbjct: 7 SLPKDFEWGFATAAYQIEGAVKEGGRGPS---IWDTYCHLEPSRTNGA---NGDVACDHY 60 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLP-TGNLSAVNRQALRYYRCVVSEGLKLGISAM 638 + ++L + YRF+L W+ ++P G L +N + +++Y ++ LK G++ Sbjct: 61 HRYDEDFDLLTKYGAKAYRFSLSWSRIIPLGGRLDPINEEGIQFYSNLIDALLKRGVTPW 120 Query: 639 VTLYYPTHAHLGLPEPLLHA-DGWLNPSTAE-AFQAYAGLCFQELGDLVKLWITINEPNR 696 VTLY H LP+ L GWLN + F+ YA LCF+ GD VK WITINEP Sbjct: 121 VTLY-----HWDLPQALHDRYGGWLNVKEVQLDFERYARLCFERFGDRVKNWITINEPWI 175 Query: 697 LSDIYNRSGNDTYG-------------------AAHNLLVAHALAWRLYDRQFRPSQRGA 737 S +G++ G A +++HA A +Y + FR SQ+G Sbjct: 176 QSIYGYATGSNAPGRSSINKHSTEGDTTTEPWLAGKAQIMSHARAVAVYSKDFRASQKGQ 235 Query: 738 VSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRG 797 + +SL+ D+ EP + AAER ++F I W+A P+F DYPA+MR+ + + Sbjct: 236 IGISLNGDYYEPWDSSDPRDKEAAERRMEFHIGWYANPIFLKKDYPASMRKQLGDR---- 291 Query: 798 LSSSALPRLTEAERRLL-KGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQ----- 851 LP LT A+ +L G DF +N++T++F H + + D I Q Sbjct: 292 -----LPALTPADFAILNAGETDFYGMNYYTSQFARHYEGPVPKTDFLGAIHEHQENKDG 346 Query: 852 -DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG--------IDDQALEDDRL 902 + S L P RK L V YG IYIT +G + + +D Sbjct: 347 SPVGEESGIFWLRSCPDMFRKHLARVHGLYGK-PIYITENGCPCPGEDKMTCEEAINDPF 405 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----K 952 R Y +L + KA D V +KGY+A+ L + PRFG +D+ K Sbjct: 406 RIQYFDSHLDSISKAISQDGVVVKGYFAWALLDNLEWSDGYGPRFGVTYTDYTTLKRTPK 465 Query: 953 SSIQFYNKVISSR 965 S + + R Sbjct: 466 KSALVLKDMFADR 478 >4A3Y-A nrPDB Length = 540 Score = 546 bits (1406), Expect = e-155, Method: Composition-based stats. Identities = 153/515 (29%), Positives = 251/515 (48%), Gaps = 73/515 (14%) Query: 62 SKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--- 118 +++ N++ FP +F G G+ A Q+EG + G+GPSIWD F H Sbjct: 3 TQSSAVIDSNDATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPSIWDTFTHRRPDMI 62 Query: 119 KNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYST 177 + ++ + + DSY ++D++ L +G+ Y+FSISW R+ P G ++ N +G+ YY+ Sbjct: 63 RGGTNGDVAVDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNN 122 Query: 178 LLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWI 237 L+D L+ I+P VTL+HWD+P AL+++YGG+ + I+D F +YA CF FGDRVK+W+ Sbjct: 123 LIDGLLANGIKPFVTLFHWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRVKHWM 182 Query: 238 TIHNPYLVAWHGYGTGMHAPGE----------------------------KGNLAAVYTV 269 T++ P+ + HGY TG++APG Y V Sbjct: 183 TLNEPWTFSVHGYATGLYAPGRGRTSPEHVNHPTVQHRCSTVAPQCICSTGNPGTEPYWV 242 Query: 270 GHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGW 329 H+L+ AH+ Y F+ Q+G + I+ + W+EP + D+ +++ +LGW Sbjct: 243 THHLLLAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALDFMLGW 302 Query: 330 FANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNF---------- 379 F PI GDYP+ M+K + S LP FS + ++G+ DF ++ ++ Sbjct: 303 FMEPITS-GDYPKSMKKFVGSRLPKFSPEQSKMLKGSYDFVGLNYYTASYVTNASTNSSG 361 Query: 380 --------------------KPLNTMAKMGQNV--SLNLREALNWIKLEYNNPRILIAEN 417 P+ + + +R+ L + K YN P I + EN Sbjct: 362 SNNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYTKKTYNVPLIYVTEN 421 Query: 418 GWFTDSRVKT------EDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA 471 G +D+ + +++ + V QA+ D + V GY AWSLLD FEW + Sbjct: 422 GVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQAMN-DGVNVKGYFAWSLLDNFEWGEG 480 Query: 472 YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 Y +R G+ ++D+N R PK SA + +N Sbjct: 481 YGVRFGIIHIDYNDN-FARYPKDSAVWLMNSFHKN 514 Score = 467 bits (1202), Expect = e-131, Method: Composition-based stats. Identities = 139/520 (26%), Positives = 222/520 (42%), Gaps = 92/520 (17%) Query: 508 FSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGV 567 ++T + FP DF G S + E A +W+ +R + G Sbjct: 9 IDSNDATRISRSDFPADFIMGTGSSAYQIEGGARDGGRGPS---IWDTFTHRRPDMIRG- 64 Query: 568 RLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNL-SAVNRQALRYYRCV 626 + K+ + +L + + YRF++ W+ VLP G L VN++ + YY + Sbjct: 65 -GTNGDVAVDSYHLYKEDVNILKNLGLDAYRFSISWSRVLPGGRLSGGVNKEGINYYNNL 123 Query: 627 VSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLV 685 + L GI VTL+ H +P+ L G+L+P + F YA LCF E GD V Sbjct: 124 IDGLLANGIKPFVTLF-----HWDVPQALEDEYGGFLSPRIVDDFCEYAELCFWEFGDRV 178 Query: 686 KLWITINEPN---------------------------------------RLSDIYNRSGN 706 K W+T+NEP + N G Sbjct: 179 KHWMTLNEPWTFSVHGYATGLYAPGRGRTSPEHVNHPTVQHRCSTVAPQCICSTGNP-GT 237 Query: 707 DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQ 766 + Y H+LL+AHA A LY +F+ Q G + +S W EP + + S AA R L Sbjct: 238 EPYWVTHHLLLAHAAAVELYKNKFQRGQEGQIGISHATQWMEPWDENSASDVEAAARALD 297 Query: 767 FEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHF 826 F + WF EP+ +GDYP +M++++ S+ LP+ + + ++LKG+ DF LN++ Sbjct: 298 FMLGWFMEPI-TSGDYPKSMKKFVGSR---------LPKFSPEQSKMLKGSYDFVGLNYY 347 Query: 827 TTRFVMHEQLAGSR-----YDSDRDIQFLQD-----ITRLSSPTRLAVIPWGVRKLLRWV 876 T +V + S Y++D + + D I S L + P G+RK+L + Sbjct: 348 TASYVTNASTNSSGSNNFSYNTDIHVTYETDRNGVPIGPQSGSDWLLIYPEGIRKILVYT 407 Query: 877 RRNYGDMDIYITASGIDD--------QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGY 928 ++ Y IY+T +G+DD D +R YL ++ V +A + D V +KGY Sbjct: 408 KKTYNVPLIYVTENGVDDVKNTNLTLSEARKDSMRLKYLQDHIFNVRQA-MNDGVNVKGY 466 Query: 929 YAFKLAEE-----KSKPRFGFFTSDFK------AKSSIQF 957 +A+ L + RFG D+ K S + Sbjct: 467 FAWSLLDNFEWGEGYGVRFGIIHIDYNDNFARYPKDSAVW 506 >4PTW-A nrPDB Length = 452 Score = 546 bits (1406), Expect = e-155, Method: Composition-based stats. Identities = 142/456 (31%), Positives = 215/456 (47%), Gaps = 35/456 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDL 138 FP++F WG T + Q+EG++ +DGKG SIWD F HT +N + + + D Y +D+ Sbjct: 7 FPEDFIWGAATSSYQIEGAFNEDGKGESIWDRFSHTPGKIENGDTGDIACDHYHLYREDI 66 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + IG+ Y+FS SWPR+ P+G V N KGL +Y L+D L+ NI P++TLYHWDL Sbjct: 67 ELMKEIGIRSYRFSTSWPRILPEGKGRV-NQKGLDFYKRLVDNLLKANIRPMITLYHWDL 125 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ+K GGW N F +YA F+ F V W+T + P++VA+ G+ G HAPG Sbjct: 126 PQALQDK-GGWTNRDTAKYFAEYARLMFEEFNGLVDLWVTHNEPWVVAFEGHAFGNHAPG 184 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K + V H+L+ +H + P G + ITL P ++ D+ Sbjct: 185 TK-DFKTALQVAHHLLLSHGMAVDIFREEDLP---GEIGITLNLTPAYP-AGDSEKDVKA 239 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFS--EAEKHEMRGTADFFAFSFGP 376 + WF +P+ G YPE + L F+ + + DF ++ Sbjct: 240 ASLLDDYINAWFLSPVF-KGSYPEELHHIYEQNLGAFTTQPGDMDIISRDIDFLGINYYS 298 Query: 377 NNFKPL----------------NTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGW 419 +MG + L + L + EY + + I ENG Sbjct: 299 RMVVRHKPGDNLFNAEVVKMEDRPSTEMGWEIYPQGLYDILVRVNKEYTDKPLYITENGA 358 Query: 420 FTDS----RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIR 475 D K D I + + Q +A++ D + + GY WSL+D FEW Y+ R Sbjct: 359 AFDDKLTEEGKIHDEKRINYLGDHFKQAYKALK-DGVPLRGYYVWSLMDNFEWAYGYSKR 417 Query: 476 RGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLK 511 GL YVD+ + + R K SA +Y+++I + Sbjct: 418 FGLIYVDYENGNR-RFLKDSALWYREVIEKGQVEAN 452 Score = 496 bits (1277), Expect = e-140, Method: Composition-based stats. Identities = 124/469 (26%), Positives = 205/469 (43%), Gaps = 56/469 (11%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP DF WG S + E + + +W+ + G T C + Sbjct: 7 FPEDFIWGAATSSYQIEGAFNEDGKGES---IWDRFSHTPGKIENG---DTGDIACDHYH 60 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ +E++ + + YRF+ W +LP G VN++ L +Y+ +V LK I M+T Sbjct: 61 LYREDIELMKEIGIRSYRFSTSWPRILPEGK-GRVNQKGLDFYKRLVDNLLKANIRPMIT 119 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GW N TA+ F YA L F+E LV LW+T NEP ++ Sbjct: 120 LY-----HWDLPQALQDKGGWTNRDTAKYFAEYARLMFEEFNGLVDLWVTHNEPWVVAFE 174 Query: 701 YNRSGNDTY---------GAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 + GN AH+LL++H +A ++ + P G + ++L+ A PA Sbjct: 175 GHAFGNHAPGTKDFKTALQVAHHLLLSHGMAVDIFREEDLP---GEIGITLNLTPAYPAG 231 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 ++ +AA + AWF P+FK G YP + + + Sbjct: 232 D-SEKDVKAASLLDDYINAWFLSPVFK-GSYPEELHHIYEQNLGAFTT-------QPGDM 282 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRK 871 ++ +DF +N+++ V H+ D+ + + ++ R S+ + P G+ Sbjct: 283 DIISRDIDFLGINYYSRMVVRHKPG-----DNLFNAEVVKMEDRPSTEMGWEIYPQGLYD 337 Query: 872 LLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLIDKVRI 925 +L V + Y D +YIT +G DD+ E+ D R YLG + ++ KA L D V + Sbjct: 338 ILVRVNKEYTDKPLYITENGAAFDDKLTEEGKIHDEKRINYLGDHFKQAYKA-LKDGVPL 396 Query: 926 KGYYAFKLAEE-----KSKPRFGFFTSDFK------AKSSIQFYNKVIS 963 +GYY + L + RFG D++ K S +Y +VI Sbjct: 397 RGYYVWSLMDNFEWAYGYSKRFGLIYVDYENGNRRFLKDSALWYREVIE 445 >1QOX-A nrPDB Length = 449 Score = 545 bits (1404), Expect = e-155, Method: Composition-based stats. Identities = 151/456 (33%), Positives = 224/456 (49%), Gaps = 37/456 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDL 138 FP +F WG+ T A Q+EG++ +DG+G SIWD F HT K N + N + DSY +E+D+ Sbjct: 5 FPSDFKWGVATAAYQIEGAYNEDGRGMSIWDTFAHTPGKVKNGDNGNVACDSYHRVEEDV 64 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +GV Y+FSISWPR+ P G V N GL YY L+D L+ IEP TLYHWDL Sbjct: 65 QLLKDLGVKVYRFSISWPRVLPQGTGEV-NRAGLDYYHRLVDELLANGIEPFCTLYHWDL 123 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ++ GGW + ID F +YA F+ G ++K WIT + P+ +A+ G+HAPG Sbjct: 124 PQALQDQ-GGWGSRITIDAFAEYAELMFKELGGKIKQWITFNEPWCMAFLSNYLGVHAPG 182 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K +L V H+L+ AH + + G + I + W P R D+ Sbjct: 183 NK-DLQLAIDVSHHLLVAHGRAVTLFREL---GISGEIGIAPNTSWAVPYRRTK-EDMEA 237 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV--LPIFSEAEKHEMRGTADFFAFSFGP 376 C + W+ +PI+ G+YP+ M ++ P + + + DF ++ Sbjct: 238 CLRVNGWSGDWYLDPIYF-GEYPKFMLDWYENLGYKPPIVDGDMELIHQPIDFIGINYYT 296 Query: 377 NNFKPLN-----------------TMAKMGQNVS-LNLREALNWIKLEYNNPRILIAENG 418 ++ N +G + L + L + +Y NP + I ENG Sbjct: 297 SSMNRYNPGEAGGMLSSEAISMGAPKTDIGWEIYAEGLYDLLRYTADKYGNPTLYITENG 356 Query: 419 WFTDS----RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTI 474 + + D I + L Q +AI D I + GY WSL+D FEW + Y + Sbjct: 357 ACYNDGLSLDGRIHDQRRIDYLAMHLIQASRAIE-DGINLKGYMEWSLMDNFEWAEGYGM 415 Query: 475 RRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 R GL +VD+++ R PK S ++YK +I L Sbjct: 416 RFGLVHVDYDT--LVRTPKDSFYWYKGVISRGWLDL 449 Score = 496 bits (1278), Expect = e-140, Method: Composition-based stats. Identities = 122/470 (25%), Positives = 195/470 (41%), Gaps = 54/470 (11%) Query: 519 GQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTD 578 FP DF WGV + + E + + +W+ + G C Sbjct: 3 HMFPSDFKWGVATAAYQIEGAYNEDGRG---MSIWDTFAHTPGKVKNG---DNGNVACDS 56 Query: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638 + +++ +++L + V YRF++ W VLP G VNR L YY +V E L GI Sbjct: 57 YHRVEEDVQLLKDLGVKVYRFSISWPRVLPQGT-GEVNRAGLDYYHRLVDELLANGIEPF 115 Query: 639 VTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 TLY H LP+ L GW + T +AF YA L F+ELG +K WIT NEP ++ Sbjct: 116 CTLY-----HWDLPQALQDQGGWGSRITIDAFAEYAELMFKELGGKIKQWITFNEPWCMA 170 Query: 699 DIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 + N G G +H+LLVAH A L+ G + ++ + WA P Sbjct: 171 FLSNYLGVHAPGNKDLQLAIDVSHHLLVAHGRAVTLFREL---GISGEIGIAPNTSWAVP 227 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 A R + W+ +P++ G+YP M ++ + + P + + Sbjct: 228 YR-RTKEDMEACLRVNGWSGDWYLDPIY-FGEYPKFMLDWYENLGYK-------PPIVDG 278 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 + L+ +DF +N++T+ + S I + + + G+ Sbjct: 279 DMELIHQPIDFIGINYYTSSMNRYNPGEAGGMLSSEAIS----MGAPKTDIGWEIYAEGL 334 Query: 870 RKLLRWVRRNYGDMDIYITASG--IDDQALED----DRLRKYYLGKYLQEVLKAYLIDKV 923 LLR+ YG+ +YIT +G +D D D+ R YL +L + +A + D + Sbjct: 335 YDLLRYTADKYGNPTLYITENGACYNDGLSLDGRIHDQRRIDYLAMHLIQASRA-IEDGI 393 Query: 924 RIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 +KGY + L + RFG D+ K S +Y VIS Sbjct: 394 NLKGYMEWSLMDNFEWAEGYGMRFGLVHVDYDTLVRTPKDSFYWYKGVIS 443 >5IDI-A nrPDB Length = 452 Score = 543 bits (1399), Expect = e-154, Method: Composition-based stats. Identities = 159/452 (35%), Positives = 237/452 (52%), Gaps = 33/452 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDL 138 FP+ F WG+ T + Q+EGS DG G SIW F HT KN + + + D Y ++D+ Sbjct: 4 FPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDI 63 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 ++ IG Y+FSISWPR+ P+G V N KGL +Y+ ++D L+ +NI P +T+YHWDL Sbjct: 64 EIIEKIGAKAYRFSISWPRILPEGTGKV-NQKGLDFYNRIIDTLLEKNITPFITIYHWDL 122 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P +LQ K GGW N I D F +Y+ F+ FGDRVK+WIT++ ++VA G+ G+HAPG Sbjct: 123 PFSLQLK-GGWANRDIADWFAEYSRVLFENFGDRVKHWITLNELWVVAIVGHLYGVHAPG 181 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K A +TV HNL++AH+K + + G + I + + EP SE DI Sbjct: 182 MKDIYVAFHTV-HNLLRAHAKSVKVFRETVK---DGKIGIVFNNGYFEP-ASEREEDIRA 236 Query: 319 CQQSMVSVLG-WFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPN 377 + F NPI+ G+YP+ + + LP E + E++ DF ++ Sbjct: 237 ARFMHQFNNYPLFLNPIY-RGEYPDLVLEFAREYLPRNYEDDMEEIKQEIDFVGLNYYSG 295 Query: 378 NFKPLN--------------TMAKMGQN-VSLNLREALNWIKLEYNNPRILIAENGWFTD 422 + + MG V + L +K EYN + I NG D Sbjct: 296 HMVKYDPNSPARVSFVERNLPKTAMGWEIVPEGIYWILKGVKEEYNPQEVYITGNGAAFD 355 Query: 423 SRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 V K D I ++ + QV +AI+ D + + GY WSLLD FEW + Y+ R G+ Sbjct: 356 DVVSEGGKVHDQNRIDYLRAHIEQVWRAIQ-DGVPLKGYFVWSLLDNFEWAEGYSKRFGI 414 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 YVD+N+++ R K S ++Y +I+ NG + Sbjct: 415 VYVDYNTQK--RIIKDSGYWYSNVIKNNGLTD 444 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 119/476 (25%), Positives = 209/476 (43%), Gaps = 60/476 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WGV + + E SP + +W+ + + G T C + Sbjct: 3 KFPEGFLWGVATASYQIEG---SPLADGAGMSIWHTFSHTPGNVKNG---DTGDVACDHY 56 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ +E++ ++ YRF++ W +LP G VN++ L +Y ++ L+ I+ + Sbjct: 57 NRWKEDIEIIEKIGAKAYRFSISWPRILPEGT-GKVNQKGLDFYNRIIDTLLEKNITPFI 115 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 T+Y H LP L GW N A+ F Y+ + F+ GD VK WIT+NE ++ Sbjct: 116 TIY-----HWDLPFSLQLKGGWANRDIADWFAEYSRVLFENFGDRVKHWITLNELWVVAI 170 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + + G G HNLL AHA + +++ + G + + + + EPA Sbjct: 171 VGHLYGVHAPGMKDIYVAFHTVHNLLRAHAKSVKVFRETVK---DGKIGIVFNNGYFEPA 227 Query: 751 NPYADSHWRAAERFLQFEIA-WFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + + RAA QF F P+++ G+YP + E+ + LPR E Sbjct: 228 SER-EEDIRAARFMHQFNNYPLFLNPIYR-GEYPDLVLEF---------AREYLPRNYED 276 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 + +K +DF LN+++ V ++ + +R + + ++P G+ Sbjct: 277 DMEEIKQEIDFVGLNYYSGHMVKYDPNSPARVS-------FVERNLPKTAMGWEIVPEGI 329 Query: 870 RKLLRWVRRNYGDMDIYITASG--IDDQALE----DDRLRKYYLGKYLQEVLKAYLIDKV 923 +L+ V+ Y ++YIT +G DD E D+ R YL ++++V +A + D V Sbjct: 330 YWILKGVKEEYNPQEVYITGNGAAFDDVVSEGGKVHDQNRIDYLRAHIEQVWRA-IQDGV 388 Query: 924 RIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPF 969 +KGY+ + L + RFG D+ K S +Y+ VI + G Sbjct: 389 PLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYNTQKRIIKDSGYWYSNVIKNNGLTD 444 >5OGZ-A nrPDB Length = 456 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 159/455 (34%), Positives = 227/455 (49%), Gaps = 37/455 (8%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS--TNGSSDSYIFLEKD 137 TFPK+F WG T A Q+EG++ +DGKG SIWD F HT + + D Y E+D Sbjct: 5 TFPKDFIWGSATAAYQIEGAYNEDGKGESIWDRFSHTPGNIADGHTGDVACDHYHRYEED 64 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + IG+ Y+FSISWPR+FP+G N KGL +Y L + L+ I P +TLYHWD Sbjct: 65 IKIMKEIGIKSYRFSISWPRIFPEGTGK-LNQKGLDFYKRLTNLLLENGIMPAITLYHWD 123 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP LQ+K GGWKN D F +Y+ F+ GD V W T + P +V+ G+ G+HAP Sbjct: 124 LPQKLQDK-GGWKNRDTTDYFTEYSEVIFKNLGDIVPIWFTHNEPGVVSLLGHFLGIHAP 182 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G K +L V HNL+ +H K + + + I L + P SE DI Sbjct: 183 GIK-DLRTSLEVSHNLLLSHGKAVKLFREM---NIDAQIGIALNLSYHYP-ASEKAEDIE 237 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPI--FSEAEKHEMRGTADFFAFSFG 375 + S W+ +P+ G YPE K F E + + DF AF+ Sbjct: 238 AAELSFSLAGRWYLDPVL-KGRYPENALKLYKKKGIELSFPEDDLKLISQPIDFIAFNNY 296 Query: 376 PNNFKPLNT-----------------MAKMGQNVSL-NLREALNWIKLEYNNPRILIAEN 417 + F + MG + L + L + +Y P I+I+EN Sbjct: 297 SSEFIKYDPSSESGFSPANSILEKFEKTDMGWIIYPEGLYDLLMLLDRDYGKPNIVISEN 356 Query: 418 GWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYT 473 G + K EDT I +K++L+Q +AI+ D + + Y WSLLD FEW Y Sbjct: 357 GAAFKDEIGSNGKIEDTKRIQYLKDYLTQAHRAIQ-DGVNLKAYYLWSLLDNFEWAYGYN 415 Query: 474 IRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 R G+ +V+F++ ERK K S ++YK++I+ NGF Sbjct: 416 KRFGIVHVNFDT--LERKIKDSGYWYKEVIKNNGF 448 Score = 496 bits (1278), Expect = e-140, Method: Composition-based stats. Identities = 115/473 (24%), Positives = 204/473 (43%), Gaps = 54/473 (11%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 FP DF WG + + E + + +W+ + + +G T C + Sbjct: 5 TFPKDFIWGSATAAYQIEGAYNEDGKGES---IWDRFSHTPGNIADG---HTGDVACDHY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ ++++ + + YRF++ W + P G +N++ L +Y+ + + L+ GI + Sbjct: 59 HRYEEDIKIMKEIGIKSYRFSISWPRIFPEGT-GKLNQKGLDFYKRLTNLLLENGIMPAI 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+ L GW N T + F Y+ + F+ LGD+V +W T NEP +S Sbjct: 118 TLY-----HWDLPQKLQDKGGWKNRDTTDYFTEYSEVIFKNLGDIVPIWFTHNEPGVVSL 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + + G G +HNLL++H A +L+ +Q + ++L+ + PA Sbjct: 173 LGHFLGIHAPGIKDLRTSLEVSHNLLLSHGKAVKLFREMNIDAQ---IGIALNLSYHYPA 229 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + A+ AAE W+ +P+ K G YP + K E + Sbjct: 230 SEKAE-DIEAAELSFSLAGRWYLDPVLK-GRYPENALKLYKKKGIEL-------SFPEDD 280 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 +L+ +DF A N++++ F+ ++ + S + I + + P G+ Sbjct: 281 LKLISQPIDFIAFNNYSSEFIKYDPSSESGFSPANSILE----KFEKTDMGWIIYPEGLY 336 Query: 871 KLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 LL + R+YG +I I+ +G I +D R YL YL + +A + D V Sbjct: 337 DLLMLLDRDYGKPNIVISENGAAFKDEIGSNGKIEDTKRIQYLKDYLTQAHRA-IQDGVN 395 Query: 925 IKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGF 967 +K YY + L + RFG +F K S +Y +VI + GF Sbjct: 396 LKAYYLWSLLDNFEWAYGYNKRFGIVHVNFDTLERKIKDSGYWYKEVIKNNGF 448 >2E40-A nrPDB Length = 465 Score = 539 bits (1390), Expect = e-153, Method: Composition-based stats. Identities = 164/463 (35%), Positives = 239/463 (51%), Gaps = 44/463 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDL 138 PK+F WG T A Q+EGS KDG+ PSIWD F K + SS + ++DSY +D+ Sbjct: 9 LPKSFVWGYATAAYQIEGSPDKDGREPSIWDTFCKAPGKIADGSSGDVATDSYNRWREDV 68 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVT-VANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 L GV Y+FS+SW R+ P G + N G+++Y TL++ LV I P VTLYHWD Sbjct: 69 QLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTLYHWD 128 Query: 198 LPLALQEKYGGWKN-DTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 LP AL ++YGGW N + I F +YA CF+ FGD V+ WIT + P++++ GYG G+ A Sbjct: 129 LPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISVMGYGNGIFA 188 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG N + V H++I AH+ Y F+ Q G + ITL SHW+ P + Sbjct: 189 PGHVSNTE-PWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIPYD-DTDASK 246 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 ++M LG FANPI+ G+YP ++K L LP F+ E ++G++DFF + Sbjct: 247 EATLRAMEFKLGRFANPIY-KGEYPPRIKKILGDRLPEFTPEEIELVKGSSDFFGLNTYT 305 Query: 377 NNFKP----------------------LNTMAKMGQ--NVSLNLREALNWIKLEYNNPRI 412 + L T + MG R LN++ Y+ P + Sbjct: 306 THLVQDGGSDELAGFVKTGHTRADGTQLGTQSDMGWLQTYGPGFRWLLNYLWKAYDKP-V 364 Query: 413 LIAENGWFTDSRVK------TEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGF 466 + ENG+ +DT +++ +LQA+ D V GY WSLLD F Sbjct: 365 YVTENGFPVKGENDLPVEQAVDDTDRQAYYRDYTEALLQAVTEDGADVRGYFGWSLLDNF 424 Query: 467 EWQDAYTIRRGLFYVDFNSKQKERKPKSSA----HYYKQIIRE 505 EW + Y +R G+ +VD+ +++ R PK SA ++K+ I E Sbjct: 425 EWAEGYKVRFGVTHVDYETQK--RTPKKSAEFLSRWFKEHIEE 465 Score = 455 bits (1170), Expect = e-128, Method: Composition-based stats. Identities = 127/481 (26%), Positives = 218/481 (45%), Gaps = 61/481 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 + P F WG + + E +W+ +G + + Sbjct: 8 KLPKSFVWGYATAAYQIEGSPDKDGREPS---IWDTFCKAPGKIADG---SSGDVATDSY 61 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLS-AVNRQALRYYRCVVSEGLKLGISAM 638 ++ +++L V YRF+L W+ ++P G S VN +++YR ++ E +K GI+ Sbjct: 62 NRWREDVQLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPF 121 Query: 639 VTLYYPTHAHLGLPEPLLHA-DGWLN-PSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 VTLY H LP+ L GWLN + F YA LCF+ GDLV+ WIT NEP Sbjct: 122 VTLY-----HWDLPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWV 176 Query: 697 LSDIYNRSG---------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747 +S + +G + + +H++++AHA A +LY +F+ Q G + ++L + W Sbjct: 177 ISVMGYGNGIFAPGHVSNTEPWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWL 236 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT 807 P + D+ A R ++F++ FA P++K G+YP +++ + + LP T Sbjct: 237 IPYDD-TDASKEATLRAMEFKLGRFANPIYK-GEYPPRIKKILGDR---------LPEFT 285 Query: 808 EAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPT---RLAV 864 E L+KG+ DF LN +TT V + + + D T+L + + L Sbjct: 286 PEEIELVKGSSDFFGLNTYTTHLVQ-DGGSDELAGFVKTGHTRADGTQLGTQSDMGWLQT 344 Query: 865 IPWGVRKLLRWVRRNYGDMDIYITASGI-----DDQALE---DDRLRKYYLGKYLQEVLK 916 G R LL ++ + Y D +Y+T +G +D +E DD R+ Y Y + +L+ Sbjct: 345 YGPGFRWLLNYLWKAY-DKPVYVTENGFPVKGENDLPVEQAVDDTDRQAYYRDYTEALLQ 403 Query: 917 AYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSI----QFYNKVI 962 A D ++GY+ + L + K RFG D++ K S +++ + I Sbjct: 404 AVTEDGADVRGYFGWSLLDNFEWAEGYKVRFGVTHVDYETQKRTPKKSAEFLSRWFKEHI 463 Query: 963 S 963 Sbjct: 464 E 464 >1BGG-A nrPDB Length = 448 Score = 539 bits (1390), Expect = e-153, Method: Composition-based stats. Identities = 150/452 (33%), Positives = 225/452 (49%), Gaps = 35/452 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDL 138 FP++F WG T A Q+EG++++DG+G SIWD F HT K N + N + DSY E+D+ Sbjct: 6 FPQDFMWGTATAAYQIEGAYQEDGRGLSIWDTFAHTPGKVFNGDNGNVACDSYHRYEEDI 65 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FS+SWPR+FP+G V N +GL YY ++D L IEP TLYHWDL Sbjct: 66 RLMKELGIRTYRFSVSWPRIFPNGDGEV-NQEGLDYYHRVVDLLNDNGIEPFCTLYHWDL 124 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ALQ+ GGW N I F +A F+ F ++++W+T + P+ +A+ G+HAPG Sbjct: 125 PQALQDA-GGWGNRRTIQAFVQFAETMFREFHGKIQHWLTFNEPWCIAFLSNMLGVHAPG 183 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 NL VGH+L+ AH + G + I W P S + D Sbjct: 184 LT-NLQTAIDVGHHLLVAHGLSVRRFREL---GTSGQIGIAPNVSWAVP-YSTSEEDKAA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV--LPIFSEAEKHEMRGTADFFAFSFGP 376 C +++ WF PI+ G YP+ + + + + D ++ Sbjct: 239 CARTISLHSDWFLQPIY-QGSYPQFLVDWFAEQGATVPIQDGDMDIIGEPIDMIGINYYS 297 Query: 377 NNFKPLN---------------TMAKMGQNV-SLNLREALNWIKLEYNNPRILIAENGWF 420 + N + +G V S L E L++++ +Y N I I ENG Sbjct: 298 MSVNRFNPEAGFLQSEEINMGLPVTDIGWPVESRGLYEVLHYLQ-KYGNIDIYITENGAC 356 Query: 421 TDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRG 477 + V K +D I M+ L QV + I D + V GY AWSLLD FEW + Y +R G Sbjct: 357 INDEVVNGKVQDDRRISYMQQHLVQVHRTIH-DGLHVKGYMAWSLLDNFEWAEGYNMRFG 415 Query: 478 LFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 + +VDF + + R PK S ++Y+ ++ N Sbjct: 416 MIHVDFRT--QVRTPKESYYWYRNVVSNNWLE 445 Score = 478 bits (1230), Expect = e-135, Method: Composition-based stats. Identities = 112/473 (23%), Positives = 201/473 (42%), Gaps = 56/473 (11%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 QFP DF WG + + E L +W+ + G C + Sbjct: 5 QFPQDFMWGTATAAYQIEGAYQEDGRG---LSIWDTFAHTPGKVFNG---DNGNVACDSY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ + ++ + + YRF++ W + P G+ VN++ L YY VV GI Sbjct: 59 HRYEEDIRLMKELGIRTYRFSVSWPRIFPNGD-GEVNQEGLDYYHRVVDLLNDNGIEPFC 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+ L A GW N T +AF +A F+E ++ W+T NEP ++ Sbjct: 118 TLY-----HWDLPQALQDAGGWGNRRTIQAFVQFAETMFREFHGKIQHWLTFNEPWCIAF 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + N G G H+LLVAH L+ R + G + ++ + WA P Sbjct: 173 LSNMLGVHAPGLTNLQTAIDVGHHLLVAHGLSVRRFREL---GTSGQIGIAPNVSWAVPY 229 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + ++ A R + WF +P+++ G YP + ++ A + A + + + Sbjct: 230 S-TSEEDKAACARTISLHSDWFLQPIYQ-GSYPQFLVDWFAEQ-------GATVPIQDGD 280 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 ++ +D +N+++ AG + + + + V G+ Sbjct: 281 MDIIGEPIDMIGINYYSMSVNRFNPEAGFLQSEEIN------MGLPVTDIGWPVESRGLY 334 Query: 871 KLLRWVRRNYGDMDIYITASG--IDDQAL---EDDRLRKYYLGKYLQEVLKAYLIDKVRI 925 ++L ++++ YG++DIYIT +G I+D+ + D R Y+ ++L +V + + D + + Sbjct: 335 EVLHYLQK-YGNIDIYITENGACINDEVVNGKVQDDRRISYMQQHLVQVHR-TIHDGLHV 392 Query: 926 KGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFP 968 KGY A+ L + RFG DF+ K S +Y V+S+ Sbjct: 393 KGYMAWSLLDNFEWAEGYNMRFGMIHVDFRTQVRTPKESYYWYRNVVSNNWLE 445 >1CBG-A nrPDB Length = 490 Score = 533 bits (1373), Expect = e-151, Method: Composition-based stats. Identities = 167/493 (33%), Positives = 249/493 (50%), Gaps = 61/493 (12%) Query: 64 NPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV-- 121 +F+ +N S F F +G + A Q EG+ +DGKGPSIWD F H + + + Sbjct: 8 FDDFSDLNRS------CFAPGFVFGTASSAFQYEGAAFEDGKGPSIWDTFTHKYPEKIKD 61 Query: 122 -SSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVA-NAKGLQYYSTLL 179 ++ + + D Y ++D+ + + + Y+FSISWPR+ P G ++ N +G+ YY+ L+ Sbjct: 62 RTNGDVAIDEYHRYKEDIGIMKDMNLDAYRFSISWPRVLPKGKLSGGVNREGINYYNNLI 121 Query: 180 DALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITI 239 + ++ ++P VTL+HWD+P AL+++Y G+ I+D F DYA CF+ FGDRVK+WIT+ Sbjct: 122 NEVLANGMQPYVTLFHWDVPQALEDEYRGFLGRNIVDDFRDYAELCFKEFGDRVKHWITL 181 Query: 240 HNPYLVAWHGYGTGMHAPGEKGNL-----------AAVYTVGHNLIKAHSKVWHNYNTHF 288 + P+ V+ + Y G APG + Y H + AH+ Y T + Sbjct: 182 NEPWGVSMNAYAYGTFAPGRCSDWLKLNCTGGDSGREPYLAAHYQLLAHAAAARLYKTKY 241 Query: 289 RPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL 348 + Q G + ITL SHW EP E D+ ++ + +LGWF +P+ G YPE MR + Sbjct: 242 QASQNGIIGITLVSHWFEPASKEK-ADVDAAKRGLDFMLGWFMHPL-TKGRYPESMRYLV 299 Query: 349 FSVLPIFSEAEKHEMRGTADFFAFSFGPNNF----------------------------K 380 LP FS E E+ G+ DF ++ + + K Sbjct: 300 RKRLPKFSTEESKELTGSFDFLGLNYYSSYYAAKAPRIPNARPAIQTDSLINATFEHNGK 359 Query: 381 PLNTMAKMGQNV--SLNLREALNWIKLEYNNPRILIAENG--WFTDSRVKTE----DTTA 432 PL MA +R+ L ++K YNNP I I ENG F D + + DT Sbjct: 360 PLGPMAASSWLCIYPQGIRKLLLYVKNHYNNPVIYITENGRNEFNDPTLSLQESLLDTPR 419 Query: 433 IYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKP 492 I L VL AI D + V GY AWSL D EW YT+R GL +VDF + K R P Sbjct: 420 IDYYYRHLYYVLTAIG-DGVNVKGYFAWSLFDNMEWDSGYTVRFGLVFVDFKNNLK-RHP 477 Query: 493 KSSAHYYKQIIRE 505 K SAH++K +++ Sbjct: 478 KLSAHWFKSFLKK 490 Score = 450 bits (1159), Expect = e-126, Method: Composition-based stats. Identities = 138/493 (27%), Positives = 224/493 (45%), Gaps = 72/493 (14%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 F F +G S + E A +W+ ++ +++ ++ Sbjct: 19 FAPGFVFGTASSAFQYEGAAFEDGKGPS---IWDTFTHKYPEKIK--DRTNGDVAIDEYH 73 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNL-SAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ + ++ M + YRF++ W VLP G L VNR+ + YY +++E L G+ V Sbjct: 74 RYKEDIGIMKDMNLDAYRFSISWPRVLPKGKLSGGVNREGINYYNNLINEVLANGMQPYV 133 Query: 640 TLYYPTHAHLGLPEPLLHAD-GWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 TL+ H +P+ L G+L + + F+ YA LCF+E GD VK WIT+NEP +S Sbjct: 134 TLF-----HWDVPQALEDEYRGFLGRNIVDDFRDYAELCFKEFGDRVKHWITLNEPWGVS 188 Query: 699 D---------------------IYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGA 737 SG + Y AAH L+AHA A RLY +++ SQ G Sbjct: 189 MNAYAYGTFAPGRCSDWLKLNCTGGDSGREPYLAAHYQLLAHAAAARLYKTKYQASQNGI 248 Query: 738 VSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRG 797 + ++L + W EPA+ + AA+R L F + WF PL K G YP +MR + + Sbjct: 249 IGITLVSHWFEPAS-KEKADVDAAKRGLDFMLGWFMHPLTK-GRYPESMRYLVRKR---- 302 Query: 798 LSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQ-----LAGSRYDSDRDIQFL-- 850 LP+ + E + L G+ DF LN++++ + + DS + F Sbjct: 303 -----LPKFSTEESKELTGSFDFLGLNYYSSYYAAKAPRIPNARPAIQTDSLINATFEHN 357 Query: 851 -QDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD--------QALEDDR 901 + + +++ + L + P G+RKLL +V+ +Y + IYIT +G ++ Q D Sbjct: 358 GKPLGPMAASSWLCIYPQGIRKLLLYVKNHYNNPVIYITENGRNEFNDPTLSLQESLLDT 417 Query: 902 LRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK------ 950 R Y ++L VL A + D V +KGY+A+ L + RFG DFK Sbjct: 418 PRIDYYYRHLYYVLTA-IGDGVNVKGYFAWSLFDNMEWDSGYTVRFGLVFVDFKNNLKRH 476 Query: 951 AKSSIQFYNKVIS 963 K S ++ + Sbjct: 477 PKLSAHWFKSFLK 489 >1E55-A nrPDB Length = 512 Score = 529 bits (1364), Expect = e-150, Method: Composition-based stats. Identities = 155/504 (30%), Positives = 238/504 (47%), Gaps = 63/504 (12%) Query: 70 VNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK---NVSSTNG 126 ++ S++ D FP +F +G T A Q+EG+W +DGKG S WDHF H H + + S+++ Sbjct: 13 LSPSEIPQRDWFPSDFTFGAATSAYQIEGAWNEDGKGESNWDHFCHNHPERILDGSNSDI 72 Query: 127 SSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGI-VTVANAKGLQYYSTLLDALVLR 185 ++SY + D+ L +G+ Y+FSISWPR+ P G N G++YY L++ L+ Sbjct: 73 GANSYHMYKTDVRLLKEMGMDAYRFSISWPRILPKGTKEGGINPDGIKYYRNLINLLLEN 132 Query: 186 NIEPIVTLYHWDLPLALQEKYGGWKNDT---IIDIFNDYATYCFQMFGDRVKYWITIHNP 242 IEP VT++HWD+P AL+EKYGG+ + + I++ + +A CF FGD+VK W+T ++P Sbjct: 133 GIEPYVTIFHWDVPQALEEKYGGFLDKSHKSIVEDYTYFAKVCFDNFGDKVKNWLTFNDP 192 Query: 243 YLVAWHGYGTGMHAPGEKGN-----------LAAVYTVGHNLIKAHSKVWHNYNTHFRPH 291 YGTG+ APG L YT GHN++ AH++ YN H++ Sbjct: 193 QTFTSFSYGTGVFAPGRCSPGLDCAYPTGNSLVEPYTAGHNILLAHAEAVDLYNKHYKRD 252 Query: 292 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 351 + + P + +D ++S LGWF P+ GDYP MR Sbjct: 253 -DTRIGLAFDVMGRVP-YGTSFLDKQAEERSWDINLGWFLEPV-VRGDYPFSMRSLARER 309 Query: 352 LPIFSEAEKHEMRGTADFFAFSFGPNNF------------------------------KP 381 LP F + +K ++ G+ + ++ + F KP Sbjct: 310 LPFFKDEQKEKLAGSYNMLGLNYYTSRFSKNIDISPNYSPVLNTDDAYASQEVNGPDGKP 369 Query: 382 LNTMAKMGQNV--SLNLREALNWIKLEYNNPRILIAENGWFTDS--------RVKTEDTT 431 + L++ L +K +Y NP I I ENG D Sbjct: 370 IGPPMGNPWIYMYPEGLKDLLMIMKNKYGNPPIYITENGIGDVDTKETPLPMEAALNDYK 429 Query: 432 AIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERK 491 + ++ ++ + ++I L V GY AWSLLD FEW +T R G+ YVD N+ R Sbjct: 430 RLDYIQRHIATLKESIDL-GSNVQGYFAWSLLDNFEWFAGFTERYGIVYVDRNNNC-TRY 487 Query: 492 PKSSAHYYKQIIRENGFSLKESTP 515 K SA + K+ S K TP Sbjct: 488 MKESAKWLKEFNTAKKPSKKILTP 511 Score = 444 bits (1142), Expect = e-124, Method: Composition-based stats. Identities = 116/520 (22%), Positives = 211/520 (40%), Gaps = 81/520 (15%) Query: 500 KQIIRENGFS-LKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGN 558 ++ +NG L S + FP DF++G S + E + + + W+ + Sbjct: 2 ARVGSQNGVQMLSPSEIPQRDWFPSDFTFGAATSAYQIEGAWNEDGKGESN---WDHFCH 58 Query: 559 RLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGN-LSAVNR 617 R+ + + K + +L M + YRF++ W +LP G +N Sbjct: 59 NHPERI--LDGSNSDIGANSYHMYKTDVRLLKEMGMDAYRFSISWPRILPKGTKEGGINP 116 Query: 618 QALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-DGWLN---PSTAEAFQAY 673 ++YYR +++ L+ GI VT++ H +P+ L G+L+ S E + + Sbjct: 117 DGIKYYRNLINLLLENGIEPYVTIF-----HWDVPQALEEKYGGFLDKSHKSIVEDYTYF 171 Query: 674 AGLCFQELGDLVKLWITINEPNRLSDIYNRSG---------------------NDTYGAA 712 A +CF GD VK W+T N+P + +G + Y A Sbjct: 172 AKVCFDNFGDKVKNWLTFNDPQTFTSFSYGTGVFAPGRCSPGLDCAYPTGNSLVEPYTAG 231 Query: 713 HNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF 772 HN+L+AHA A LY++ ++ + L+ P +A ER + WF Sbjct: 232 HNILLAHAEAVDLYNKHYKRD-DTRIGLAFDVMGRVPYGTSF-LDKQAEERSWDINLGWF 289 Query: 773 AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVM 832 EP+ + GDYP +MR L+ LP + ++ L G+ + LN++T+RF Sbjct: 290 LEPVVR-GDYPFSMRS---------LARERLPFFKDEQKEKLAGSYNMLGLNYYTSRFSK 339 Query: 833 HEQLAGSRYD----------SDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGD 882 + ++ + + + + I + + P G++ LL ++ YG+ Sbjct: 340 NIDISPNYSPVLNTDDAYASQEVNGPDGKPIGPPMGNPWIYMYPEGLKDLLMIMKNKYGN 399 Query: 883 MDIYITASGIDD----------QALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFK 932 IYIT +GI D +A +D R Y+ +++ LK + ++GY+A+ Sbjct: 400 PPIYITENGIGDVDTKETPLPMEAALNDYKRLDYIQRHI-ATLKESIDLGSNVQGYFAWS 458 Query: 933 LAEE-----KSKPRFGFFTSDFKA------KSSIQFYNKV 961 L + R+G D K S ++ + Sbjct: 459 LLDNFEWFAGFTERYGIVYVDRNNNCTRYMKESAKWLKEF 498 >5XGZ-A nrPDB Length = 457 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 132/458 (28%), Positives = 218/458 (47%), Gaps = 32/458 (6%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSS--DSYIFLEKDL 138 FP +F WG+ T + Q+EG+ + DG+ PSIWD F + G+ D Y +D+ Sbjct: 10 FPPDFQWGVATSSYQIEGAVEADGRSPSIWDTFCARPGAIADGSTGAIANDHYHRYREDI 69 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + + +GV+ Y+FSI+WPR+ PDG V N G+ +Y L+D+L+ + IEP TLYHWD+ Sbjct: 70 AIMKQLGVNAYRFSIAWPRILPDGRGRV-NQAGVDFYERLVDSLLEQGIEPYATLYHWDM 128 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ++ W + ++D F +Y + DRVKYW+T++ P+++++ GYG G HAPG Sbjct: 129 PQVQHDRT-PWYDRGVVDAFVEYTDVITRRLSDRVKYWMTLNEPWVISFLGYGAGEHAPG 187 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + H+++ AH K + K I L +W+ S++ D Sbjct: 188 LRDK-ELYLRAAHHVLLAHGKAMPVIRANGNAQTKA--GIVLNLNWVN-AASDSPEDQAA 243 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ WFA P++ +G YPE + + L + + DF A ++ Sbjct: 244 ARRYDQFFNRWFAEPLY-NGRYPEELLEWYGRDLVPVQPGDFDIITTPTDFLAVNYYART 302 Query: 379 FK---------------PLNTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTD 422 P M V L LNW+ +Y P + + ENG D Sbjct: 303 TVKAGSTDPMLQVDFVRPPGEYTAMDWEVYPQGLYNILNWLHTDYAPPALYVTENGAAYD 362 Query: 423 SRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGL 478 +V + +D + ++ +AI+ I + GY WSL+D FEW + R G+ Sbjct: 363 DQVSAAGEVDDPQRLAYLEGHFEAAYRAIQA-GIPLKGYFVWSLMDNFEWGRGFEKRFGI 421 Query: 479 FYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPD 516 +VD+ ++Q R K S ++ Q+ R NG ++T + Sbjct: 422 VFVDYATQQ--RIIKRSGKWFSQVTRANGLPAPQTTLE 457 Score = 490 bits (1262), Expect = e-138, Method: Composition-based stats. Identities = 117/486 (24%), Positives = 202/486 (41%), Gaps = 57/486 (11%) Query: 513 STPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTR 572 ST + +FP DF WGV S + E + S +W+ R +G T Sbjct: 2 STQNEPHRFPPDFQWGVATSSYQIEGAVEADGRSPS---IWDTFCARPGAIADG---STG 55 Query: 573 PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 + ++ + ++ ++ V YRF++ W +LP G VN+ + +Y +V L+ Sbjct: 56 AIANDHYHRYREDIAIMKQLGVNAYRFSIAWPRILPDGR-GRVNQAGVDFYERLVDSLLE 114 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI TLY H +P+ W + +AF Y + + L D VK W+T+N Sbjct: 115 QGIEPYATLY-----HWDMPQVQHDRTPWYDRGVVDAFVEYTDVITRRLSDRVKYWMTLN 169 Query: 693 EPNRLSDIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLH 743 EP +S + +G G AAH++L+AH A + + + L+L+ Sbjct: 170 EPWVISFLGYGAGEHAPGLRDKELYLRAAHHVLLAHGKAMPVIRANGNAQTKAGIVLNLN 229 Query: 744 ADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSAL 803 W A+ + AA R+ QF WFAEPL+ G YP + E+ L Sbjct: 230 --WVNAASDSPE-DQAAARRYDQFFNRWFAEPLY-NGRYPEELLEWYGRD---------L 276 Query: 804 PRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLA 863 + + ++ DF A+N++ V D + F++ + Sbjct: 277 VPVQPGDFDIITTPTDFLAVNYYARTTVK-----AGSTDPMLQVDFVRPPGEY-TAMDWE 330 Query: 864 VIPWGVRKLLRWVRRNYGDMDIYITASG--IDDQ----ALEDDRLRKYYLGKYLQEVLKA 917 V P G+ +L W+ +Y +Y+T +G DDQ DD R YL + + +A Sbjct: 331 VYPQGLYNILNWLHTDYAPPALYVTENGAAYDDQVSAAGEVDDPQRLAYLEGHFEAAYRA 390 Query: 918 YLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGF 967 + + +KGY+ + L + + RFG D+ K S +++++V + G Sbjct: 391 -IQAGIPLKGYFVWSLMDNFEWGRGFEKRFGIVFVDYATQQRIIKRSGKWFSQVTRANGL 449 Query: 968 PFENSS 973 P ++ Sbjct: 450 PAPQTT 455 >4HZ6-A nrPDB Length = 444 Score = 527 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 130/450 (28%), Positives = 204/450 (45%), Gaps = 30/450 (6%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI--HTHLKNVSSTNGSSDSYIFLEKDL 138 FP+ F WG T + Q+EG+W +DGKG SIWD F +KN S + + D Y E+DL Sbjct: 5 FPEGFLWGAATSSYQIEGAWNEDGKGESIWDRFTRIPGKIKNGDSGDVACDHYHRYEQDL 64 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FSI+W R+ PD N +GL +Y L++ L R+I P+ TLYHWDL Sbjct: 65 DLMRQLGLKTYRFSIAWARIQPD-SSRQINQRGLDFYRRLVEGLHKRDILPMATLYHWDL 123 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ++++ GGW + F +Y GD++ W+T + P + W GY G+ APG Sbjct: 124 PQWVEDE-GGWLSRESASRFAEYTHALVAALGDQIPLWVTHNEPMVTVWAGYHMGLFAPG 182 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 K V H+L+ +H + + + ITL + I P +E D+ Sbjct: 183 LKDPTLGG-RVAHHLLLSHGQALQAFRALSPAGS--QMGITLNFNTIYPVSAE-PADVEA 238 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 ++ F P+ G Y + ++ + + + DF ++ Sbjct: 239 ARRMHSFQNELFLEPLI-RGQYNQATLMAYPNLPEFIAPEDMQTISAPIDFLGVNYYNPM 297 Query: 379 FKPLNT-------------MAKMGQNV-SLNLREALNWIKLEYNNPRILIAENGWFTDSR 424 + + MG + L + L I Y I I ENG D + Sbjct: 298 RVKSSPQPPGIEVVQVESPVTAMGWEIAPEGLYDLLMGITRTYGKLPIYITENGAAFDDQ 357 Query: 425 ----VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFY 480 + D + + + +A+ D + + GY AWSLLD FEW + Y+ R G+ Y Sbjct: 358 PDQSGQVNDPQRVGYFQGHIGAARRAL-ADGVDLRGYYAWSLLDNFEWAEGYSKRFGIIY 416 Query: 481 VDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 VDF ++Q R K SA +Y+ +I NG Sbjct: 417 VDFETQQ--RTLKQSAQWYRDVIANNGLED 444 Score = 474 bits (1221), Expect = e-134, Method: Composition-based stats. Identities = 113/476 (23%), Positives = 187/476 (39%), Gaps = 61/476 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WG S + E + + +W+ G + C + Sbjct: 4 KFPEGFLWGAATSSYQIEGAWNEDGKGES---IWDRFTRIPGKIKNG---DSGDVACDHY 57 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ L+++ ++ + YRF++ WA + P + +N++ L +YR +V K I M Sbjct: 58 HRYEQDLDLMRQLGLKTYRFSIAWARIQPDSSR-QINQRGLDFYRRLVEGLHKRDILPMA 116 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+ + GWL+ +A F Y LGD + LW+T NEP Sbjct: 117 TLY-----HWDLPQWVEDEGGWLSRESASRFAEYTHALVAALGDQIPLWVTHNEPMVTVW 171 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 G G AH+LL++H A + + + ++L+ + + A Sbjct: 172 AGYHMGLFAPGLKDPTLGGRVAHHLLLSHGQALQAFRALSPAGSQMGITLNFNTIYPVSA 231 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRL-TEA 809 P + AA R F+ F EPL + G Y A ++ LP Sbjct: 232 EP---ADVEAARRMHSFQNELFLEPLIR-GQYNQATL----------MAYPNLPEFIAPE 277 Query: 810 ERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGV 869 + + + +DF +N++ V + + + + P G+ Sbjct: 278 DMQTISAPIDFLGVNYYNPMRVKSSPQPPG--------IEVVQVESPVTAMGWEIAPEGL 329 Query: 870 RKLLRWVRRNYGDMDIYITASG--IDDQ----ALEDDRLRKYYLGKYLQEVLKAYLIDKV 923 LL + R YG + IYIT +G DDQ +D R Y ++ +A L D V Sbjct: 330 YDLLMGITRTYGKLPIYITENGAAFDDQPDQSGQVNDPQRVGYFQGHIGAARRA-LADGV 388 Query: 924 RIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPF 969 ++GYYA+ L + RFG DF+ K S Q+Y VI++ G Sbjct: 389 DLRGYYAWSLLDNFEWAEGYSKRFGIIYVDFETQQRTLKQSAQWYRDVIANNGLED 444 >3VIK-A nrPDB Length = 487 Score = 526 bits (1354), Expect = e-149, Method: Composition-based stats. Identities = 158/469 (33%), Positives = 235/469 (50%), Gaps = 44/469 (9%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK---NVSSTNGSSDSYIFLEK 136 TFP F G T + Q+EG+W ++GKGP+IWD H H + ++ + + DSY ++ Sbjct: 11 TFPDEFKLGAATASYQIEGAWDENGKGPNIWDTLTHEHPDYVVDGATGDIADDSYHLYKE 70 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 D+ L +G Y+FSISW R+ P+G + N G+ YY+ L++ L+ IEP+VT+YHW Sbjct: 71 DVKILKELGAQVYRFSISWARVLPEGHDNIVNQDGIDYYNNLINELLANGIEPMVTMYHW 130 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGM-H 255 DLP ALQ+ GGW N + +YA F+ FGDRVK W+T ++P GY + + Sbjct: 131 DLPQALQD-LGGWPNLVLAKYSENYARVLFKNFGDRVKLWLTFNSPLTF-MDGYASEIGM 188 Query: 256 APGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMD 315 AP Y H +I AH++++H Y+ FR Q G + I+L +W EP + + D Sbjct: 189 APSINTPGIGDYLAAHTVIHAHARIYHLYDQEFRAEQGGKVGISLNINWCEP-ATNSAED 247 Query: 316 IFKCQQSMVSVLGWFANPIHG-DGDYPEGMRKKLF----------SVLPIFSEAEKHEMR 364 C+ LG +A+PI +GDYP ++ ++ S LP F+ E +R Sbjct: 248 RASCENYQQFNLGLYAHPIFTEEGDYPAVLKDRVSRNSADEGYTDSRLPQFTAEEVEYIR 307 Query: 365 GTADFFAFSFGPNNFKPLN------------------------TMAKMGQNVSLNLREAL 400 GT DF +F + + + V R+ L Sbjct: 308 GTHDFLGINFYTALLGKSGVEGYEPSRYRDSGVILTQDAAWPISASSWLKVVPWGFRKEL 367 Query: 401 NWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460 NWIK EYNNP + I ENG+ DT ++ L ++L+AI D + V GYTAW Sbjct: 368 NWIKNEYNNPPVFITENGFSDYGG--LNDTGRVHYYTEHLKEMLKAIHEDGVNVIGYTAW 425 Query: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 SL+D FEW Y+ + G++ VDF + R PK SA +I+ Sbjct: 426 SLMDNFEWLRGYSEKFGIYAVDFEDPARPRIPKESAKVLAEIMNTRKIP 474 Score = 491 bits (1265), Expect = e-139, Method: Composition-based stats. Identities = 144/484 (29%), Positives = 228/484 (47%), Gaps = 37/484 (7%) Query: 511 KESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLK 570 ++ D FP +F G + + E +W+ + V V Sbjct: 2 DVASSDTVYTFPDEFKLGAATASYQIEGAWDENGKGP---NIWDTLTHEHPDYV--VDGA 56 Query: 571 TRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEG 630 T + K+ +++L + YRF++ WA VLP G+ + VN+ + YY +++E Sbjct: 57 TGDIADDSYHLYKEDVKILKELGAQVYRFSISWARVLPEGHDNIVNQDGIDYYNNLINEL 116 Query: 631 LKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWIT 690 L GI MVT+Y H LP+ L GW N A+ + YA + F+ GD VKLW+T Sbjct: 117 LANGIEPMVTMY-----HWDLPQALQDLGGWPNLVLAKYSENYARVLFKNFGDRVKLWLT 171 Query: 691 INEPNRLSDIY----------NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL 740 N P D Y N G Y AAH ++ AHA + LYD++FR Q G V + Sbjct: 172 FNSPLTFMDGYASEIGMAPSINTPGIGDYLAAHTVIHAHARIYHLYDQEFRAEQGGKVGI 231 Query: 741 SLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLF-KTGDYPAAMREYIASKH-RRGL 798 SL+ +W EPA A+ + E + QF + +A P+F + GDYPA +++ ++ G Sbjct: 232 SLNINWCEPATNSAE-DRASCENYQQFNLGLYAHPIFTEEGDYPAVLKDRVSRNSADEGY 290 Query: 799 SSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMH--EQLAGSRYDSDRDIQFLQDITRL 856 + S LP+ T E ++GT DF +N +T E SRY I + Sbjct: 291 TDSRLPQFTAEEVEYIRGTHDFLGINFYTALLGKSGVEGYEPSRYRDSGVILTQDAAWPI 350 Query: 857 SSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLK 916 S+ + L V+PWG RK L W++ Y + ++IT +G D +D R +Y ++L+E+LK Sbjct: 351 SASSWLKVVPWGFRKELNWIKNEYNNPPVFITENGFSDYGGLNDTGRVHYYTEHLKEMLK 410 Query: 917 AYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK-------AKSSIQFYNKVISS 964 A D V + GY A+ L + +FG + DF+ K S + +++++ Sbjct: 411 AIHEDGVNVIGYTAWSLMDNFEWLRGYSEKFGIYAVDFEDPARPRIPKESAKVLAEIMNT 470 Query: 965 RGFP 968 R P Sbjct: 471 RKIP 474 >4JIE-A nrPDB Length = 503 Score = 524 bits (1349), Expect = e-148, Method: Composition-based stats. Identities = 159/483 (32%), Positives = 244/483 (50%), Gaps = 49/483 (10%) Query: 68 TPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTN 125 + ++ FP+ F +G A QVEG K+ G+GPSIWD FI N ++ + Sbjct: 25 PEIYDAGGLSRRAFPEGFVFGTAASAYQVEGMAKQGGRGPSIWDAFIEKPGTIPNNATAD 84 Query: 126 GSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLR 185 + D Y ++D++ + +G Y+FSISW R+FP+G V N +G+ YY+ L+D +V + Sbjct: 85 VTVDEYHRYKEDVNIMKNMGFDAYRFSISWSRIFPNGTGMV-NQEGVDYYNRLIDYMVKK 143 Query: 186 NIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLV 245 I+P LYH+DLPLAL E+Y GW + I++ F DYA +CFQ FGDRVK W T + P V Sbjct: 144 GIKPYANLYHYDLPLALHEQYLGWLSPNIVEAFADYADFCFQTFGDRVKDWFTFNEPRCV 203 Query: 246 AWHGYGTGMHAPGEK-------GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSI 298 A GY G HAPG + Y H+LI +H+ Y ++ +QKG + I Sbjct: 204 AALGYDNGFHAPGRCSGCDAGGNSTTEPYLAAHHLILSHAAAVKRYREKYQLYQKGRIGI 263 Query: 299 TLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEA 358 L W EP S++ D Q++ LGWF +PI G YP M + + +P FS+ Sbjct: 264 LLDFVWYEPF-SDSNADRAAAQRARDFHLGWFLDPII-HGRYPYSMLEIVKDRMPTFSDE 321 Query: 359 EKHEMRGTADFFAFSFGPNNF----------------------------KPLNTMAKMGQ 390 E ++ + D+ + + + P+ A Sbjct: 322 ESRMVKDSIDYVGINHYTSFYMKDPGPWNLTPTSYQDDWHVGFAYERNGVPIGAQANSYW 381 Query: 391 --NVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKT----EDTTAIYMMKNFLSQVL 444 V + +A+ ++K Y NP ++++ENG V DT I +N+++++ Sbjct: 382 LYIVPWGINKAVTYVKETYGNPTMILSENGMDQPGNVSITQGVHDTVRIRYYRNYITELK 441 Query: 445 QAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504 +AI D +V GY AWSLLD FEW+ YT R G+ YVD+ + +R PK SA ++K ++ Sbjct: 442 KAID-DGAKVIGYFAWSLLDNFEWRLGYTSRFGIVYVDYKT--LKRYPKDSAFWFKNMLS 498 Query: 505 ENG 507 Sbjct: 499 SKK 501 Score = 459 bits (1180), Expect = e-129, Method: Composition-based stats. Identities = 123/490 (25%), Positives = 215/490 (43%), Gaps = 66/490 (13%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 + FP F +G S + E +A +W+A + T Sbjct: 35 RRAFPEGFVFGTAASAYQVEGMAKQGGRGPS---IWDAFIEKPGTIPNNA---TADVTVD 88 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637 ++ K+ + ++ M YRF++ W+ + P G VN++ + YY ++ +K GI Sbjct: 89 EYHRYKEDVNIMKNMGFDAYRFSISWSRIFPNGT-GMVNQEGVDYYNRLIDYMVKKGIKP 147 Query: 638 MVTLYYPTHAHLGLPEPLLHAD-GWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 LY H LP L GWL+P+ EAF YA CFQ GD VK W T NEP Sbjct: 148 YANLY-----HYDLPLALHEQYLGWLSPNIVEAFADYADFCFQTFGDRVKDWFTFNEPRC 202 Query: 697 LSDIYNRSGND-----------------TYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 ++ + +G Y AAH+L+++HA A + Y +++ Q+G + Sbjct: 203 VAALGYDNGFHAPGRCSGCDAGGNSTTEPYLAAHHLILSHAAAVKRYREKYQLYQKGRIG 262 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 + L W EP + A+R F + WF +P+ G YP +M E + + Sbjct: 263 ILLDFVWYEPFSDSNADRAA-AQRARDFHLGWFLDPII-HGRYPYSMLEIVKDR------ 314 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHE---QLAGSRYDSDRDIQFLQ----- 851 +P ++ E R++K ++D+ +NH+T+ ++ L + Y D + F Sbjct: 315 ---MPTFSDEESRMVKDSIDYVGINHYTSFYMKDPGPWNLTPTSYQDDWHVGFAYERNGV 371 Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQA------LEDDRLRKY 905 I ++ L ++PWG+ K + +V+ YG+ + ++ +G+D D +R Sbjct: 372 PIGAQANSYWLYIVPWGINKAVTYVKETYGNPTMILSENGMDQPGNVSITQGVHDTVRIR 431 Query: 906 YLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSI 955 Y Y+ E+ KA + D ++ GY+A+ L + RFG D+K K S Sbjct: 432 YYRNYITELKKA-IDDGAKVIGYFAWSLLDNFEWRLGYTSRFGIVYVDYKTLKRYPKDSA 490 Query: 956 QFYNKVISSR 965 ++ ++SS+ Sbjct: 491 FWFKNMLSSK 500 >1WCG-A nrPDB Length = 464 Score = 520 bits (1340), Expect = e-147, Method: Composition-based stats. Identities = 165/462 (35%), Positives = 248/462 (53%), Gaps = 42/462 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK---NVSSTNGSSDSYIFLEKD 137 FPK+F +G T + Q+EG W +DGKG +IWD +HT + + ++ + + DSY ++D Sbjct: 5 FPKDFMFGTSTASYQIEGGWNEDGKGENIWDRLVHTSPEVIKDGTNGDIACDSYHKYKED 64 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + + + FY+FSISW R+ P G++ KG+ YY+ L++ L+ +I P+VT+YHWD Sbjct: 65 VAIIKDLNLKFYRFSISWARIAPSGVMNSLEPKGIAYYNNLINELIKNDIIPLVTMYHWD 124 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP LQ+ GGW N + D F +YA F FGDRVK+WIT + P V GY +AP Sbjct: 125 LPQYLQD-LGGWVNPIMSDYFKEYARVLFTYFGDRVKWWITFNEPIAVC-KGYSIKAYAP 182 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 Y GH + AH K + Y F+P Q G +SI++ + P +E+ DI Sbjct: 183 NLNLKTTGHYLAGHTQLIAHGKAYRLYEEMFKPTQNGKISISISGVFFMPKNAESDDDIE 242 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGTA 367 +++ GWF +P++ GDYP M+K + +S LP F++ E ++GTA Sbjct: 243 TAERANQFERGWFGHPVY-KGDYPPIMKKWVDQKSKEEGLPWSKLPKFTKDEIKLLKGTA 301 Query: 368 DFFAFSFGPN-----------NFKPLNTMAKMGQN-------------VSLNLREALNWI 403 DF+A + + NF P + V LR+ L W+ Sbjct: 302 DFYALNHYSSRLVTFGSDPNPNFNPDASYVTSVDEAWLKPNETPYIIPVPEGLRKLLIWL 361 Query: 404 KLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL 463 K EY NP++LI ENG+ D + +D I +KN+L+ LQA+ D+ V GYT WSLL Sbjct: 362 KNEYGNPQLLITENGYGDDG--QLDDFEKISYLKNYLNATLQAMYEDKCNVIGYTVWSLL 419 Query: 464 DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 D FEW Y+I GL +DFN Q+ R + S Y+K ++ Sbjct: 420 DNFEWFYGYSIHFGLVKIDFNDPQRTRTKRESYTYFKNVVST 461 Score = 481 bits (1238), Expect = e-136, Method: Composition-based stats. Identities = 139/472 (29%), Positives = 224/472 (47%), Gaps = 35/472 (7%) Query: 517 VQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQC 576 + +FP DF +G + + + E + + +W+ + ++ C Sbjct: 1 MDYKFPKDFMFGTSTASYQIEGGWNEDGKGE---NIWDRLVHTSPEVIK--DGTNGDIAC 55 Query: 577 TDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS 636 + K+ + ++ + + YRF++ WA + P+G ++++ + + YY +++E +K I Sbjct: 56 DSYHKYKEDVAIIKDLNLKFYRFSISWARIAPSGVMNSLEPKGIAYYNNLINELIKNDII 115 Query: 637 AMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 +VT+Y H LP+ L GW+NP ++ F+ YA + F GD VK WIT NEP Sbjct: 116 PLVTMY-----HWDLPQYLQDLGGWVNPIMSDYFKEYARVLFTYFGDRVKWWITFNEPIA 170 Query: 697 LSDIY---------NRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747 + Y N Y A H L+AH A+RLY+ F+P+Q G +S+S+ + Sbjct: 171 VCKGYSIKAYAPNLNLKTTGHYLAGHTQLIAHGKAYRLYEEMFKPTQNGKISISISGVFF 230 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASK-HRRGLSSSALPRL 806 P N +D AER QFE WF P++K GDYP M++++ K GL S LP+ Sbjct: 231 MPKNAESDDDIETAERANQFERGWFGHPVYK-GDYPPIMKKWVDQKSKEEGLPWSKLPKF 289 Query: 807 TEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPT--RLAV 864 T+ E +LLKGT DF ALNH+++R V ++ D D L + Sbjct: 290 TKDEIKLLKGTADFYALNHYSSRLVTFGSDPNPNFNPDASYVTSVDEAWLKPNETPYIIP 349 Query: 865 IPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 +P G+RKLL W++ YG+ + IT +G D DD + YL YL L+A DK Sbjct: 350 VPEGLRKLLIWLKNEYGNPQLLITENGYGDDGQLDDFEKISYLKNYLNATLQAMYEDKCN 409 Query: 925 IKGYYAFKLAEE-----KSKPRFGFFTSDFK-------AKSSIQFYNKVISS 964 + GY + L + FG DF + S ++ V+S+ Sbjct: 410 VIGYTVWSLLDNFEWFYGYSIHFGLVKIDFNDPQRTRTKRESYTYFKNVVST 461 >5AYI-A nrPDB Length = 457 Score = 518 bits (1335), Expect = e-147, Method: Composition-based stats. Identities = 130/448 (29%), Positives = 207/448 (46%), Gaps = 32/448 (7%) Query: 79 DTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS--TNGSSDSYIFLEK 136 + FP +F WG T A Q+EG+ ++DG+G SIWD F HT K + + DSY + Sbjct: 4 ERFPADFVWGAATAAYQIEGAVREDGRGVSIWDTFSHTPGKIADGTTGDVACDSYHRYGE 63 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 D+ L+ +G++ Y+FSI+WPR+ P G N GL +YS ++DAL+ ++P VTLYHW Sbjct: 64 DIGLLNALGMNAYRFSIAWPRIVPLGAG-PINQAGLDHYSRMVDALLGAGLQPFVTLYHW 122 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP L+++ GW + +F +YA + GDRV +W T++ P+ A GY G+HA Sbjct: 123 DLPQPLEDRL-GWGSRATATVFAEYADIVVRQLGDRVTHWATLNEPWCSAMLGYYLGVHA 181 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG +L HNL+ H Q + I L P S++ D+ Sbjct: 182 PGHT-DLKRGLEASHNLLLGHGLAVQAMRAA--APQPLQIGIVLQLTPTYP-ASDSPEDV 237 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP 376 ++ V WF +P+ G G YP+ M + P + + ++ D+ ++ Sbjct: 238 AAARRFDGFVNRWFLDPLAGRG-YPQDMLDYYGAAAPQANPEDLTQIAAPLDWLGVNYYE 296 Query: 377 NNFKPLNTMAKMGQN----------------VSLNLREALNWIKLEYNNPRILIAENGWF 420 A + Q L + L + +Y + I ENG Sbjct: 297 RMRAVDAPDASLPQAQRLDDPDLPHTADREVYPEGLYDILLRLHNDYPFRPLYITENGCA 356 Query: 421 TDSRVK----TEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRR 476 + D + L+Q+ +A+ + + GY AWSLLD FEW ++R Sbjct: 357 LHDEIAEDGGIHDGQRQAFFEAHLAQLQRALAA-GVPLKGYFAWSLLDNFEWAMGLSMRY 415 Query: 477 GLFYVDFNSKQKERKPKSSAHYYKQIIR 504 G+ Y +F + ER+ K S ++ + I Sbjct: 416 GICYTNFET--LERRIKDSGYWLRDFIA 441 Score = 459 bits (1181), Expect = e-129, Method: Composition-based stats. Identities = 114/469 (24%), Positives = 189/469 (40%), Gaps = 57/469 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP DF WG + + E + +W+ + +G T C + Sbjct: 5 RFPADFVWGAATAAYQIEGAVREDGRG---VSIWDTFSHTPGKIADGT---TGDVACDSY 58 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 + + +L + + YRF++ W ++P G +N+ L +Y +V L G+ V Sbjct: 59 HRYGEDIGLLNALGMNAYRFSIAWPRIVPLG-AGPINQAGLDHYSRMVDALLGAGLQPFV 117 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP+PL GW + +TA F YA + ++LGD V W T+NEP + Sbjct: 118 TLY-----HWDLPQPLEDRLGWGSRATATVFAEYADIVVRQLGDRVTHWATLNEPWCSAM 172 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + G G A+HNLL+ H LA + Q + + L PA Sbjct: 173 LGYYLGVHAPGHTDLKRGLEASHNLLLGHGLAVQAMRAA--APQPLQIGIVLQLTPTYPA 230 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + + AA RF F WF +PL G YP M +Y +A P+ + Sbjct: 231 SDSPE-DVAAARRFDGFVNRWFLDPLAGRG-YPQDMLDYYG---------AAAPQANPED 279 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 + +D+ +N++ + A S Q L D + R V P G+ Sbjct: 280 LTQIAAPLDWLGVNYYERMRAVDAPDA-----SLPQAQRLDDPDLPHTADR-EVYPEGLY 333 Query: 871 KLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVR 924 +L + +Y +YIT +G I + D R+ + +L ++ +A L V Sbjct: 334 DILLRLHNDYPFRPLYITENGCALHDEIAEDGGIHDGQRQAFFEAHLAQLQRA-LAAGVP 392 Query: 925 IKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 +KGY+A+ L + R+G ++F+ K S + I+ Sbjct: 393 LKGYFAWSLLDNFEWAMGLSMRYGICYTNFETLERRIKDSGYWLRDFIA 441 >2Z1S-A nrPDB Length = 454 Score = 512 bits (1319), Expect = e-145, Method: Composition-based stats. Identities = 129/453 (28%), Positives = 213/453 (47%), Gaps = 37/453 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSS--TNGSSDSYIFLEKDL 138 FP F WG T + Q+EG + G+ PSIWD F K + + + D + ++D+ Sbjct: 14 FPATFMWGTSTSSYQIEGGTDEGGRTPSIWDTFCQIPGKVIGGDCGDVACDHFHHFKEDV 73 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G Y+FS++WPR+ P + N +GL +Y LLD + L + P++TLYHWDL Sbjct: 74 QLMKQLGFLHYRFSVAWPRIMP--AAGIINEEGLLFYEHLLDEIELAGLIPMLTLYHWDL 131 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P ++++ GGW I F YA+ FG+R+ +W TI+ PY + GYGTG HAPG Sbjct: 132 PQWIEDE-GGWTQRETIQHFKTYASVIMDRFGERINWWNTINEPYCASILGYGTGEHAPG 190 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + N +T H+++ H + + G + ITL ++ SE D+ Sbjct: 191 HE-NWREAFTAAHHILMCHGIASNLHKEK---GLTGKIGITLNMEHVD-AASERPEDVAA 245 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV---LPIFSEAEKHEMRGTADFFAFSFG 375 + + WFA P+ +G YPE M + + L + ++ DF ++ Sbjct: 246 AIRRDGFINRWFAEPLF-NGKYPEDMVEWYGTYLNGLDFVQPGDMELIQQPGDFLGINYY 304 Query: 376 PNNFKPL---------------NTMAKMGQNV-SLNLREALNWIKLEYNN-PRILIAENG 418 + + MG + + + L I+ +++ ILI ENG Sbjct: 305 TRSIIRSTNDASLLQVEQVHMEEPVTDMGWEIHPESFYKLLTRIEKDFSKGLPILITENG 364 Query: 419 WFTDSR---VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIR 475 + EDT ++ L + I ++ GY WS LD FEW Y+ R Sbjct: 365 AAMRDELVNGQIEDTGRQRYIEEHLKACHRFIEEGG-QLKGYFVWSFLDNFEWAWGYSKR 423 Query: 476 RGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 G+ ++++ + +ER PK SA ++KQ++ +NGF Sbjct: 424 FGIVHINYET--QERTPKQSALWFKQMMAKNGF 454 Score = 450 bits (1158), Expect = e-126, Method: Composition-based stats. Identities = 104/472 (22%), Positives = 201/472 (42%), Gaps = 56/472 (11%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F WG + S + E + +W+ + G C F Sbjct: 14 FPATFMWGTSTSSYQIEGGTDEGGRTPS---IWDTFCQIPGKVIGG---DCGDVACDHFH 67 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 + K+ ++++ ++ HYRF++ W ++P +N + L +Y ++ E G+ M+T Sbjct: 68 HFKEDVQLMKQLGFLHYRFSVAWPRIMP--AAGIINEEGLLFYEHLLDEIELAGLIPMLT 125 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ + GW T + F+ YA + G+ + W TINEP S + Sbjct: 126 LY-----HWDLPQWIEDEGGWTQRETIQHFKTYASVIMDRFGERINWWNTINEPYCASIL 180 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 +G G AAH++L+ H +A L+ + G + ++L+ + + A+ Sbjct: 181 GYGTGEHAPGHENWREAFTAAHHILMCHGIASNLHKEK---GLTGKIGITLNMEHVDAAS 237 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 + AA R F WFAEPLF G YP M E+ G + L + + Sbjct: 238 ERPE-DVAAAIRRDGFINRWFAEPLF-NGKYPEDMVEWY------GTYLNGLDFVQPGDM 289 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRK 871 L++ DF +N++T + A S ++ + + + + P K Sbjct: 290 ELIQQPGDFLGINYYTRSIIRSTNDA-----SLLQVEQVH-MEEPVTDMGWEIHPESFYK 343 Query: 872 LLRWVRRNYGD-MDIYITASG--IDDQAL---EDDRLRKYYLGKYLQEVLKAYLIDKVRI 925 LL + +++ + I IT +G + D+ + +D R+ Y+ ++L+ + ++ + ++ Sbjct: 344 LLTRIEKDFSKGLPILITENGAAMRDELVNGQIEDTGRQRYIEEHLKACHR-FIEEGGQL 402 Query: 926 KGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGF 967 KGY+ + + RFG +++ K S ++ ++++ GF Sbjct: 403 KGYFVWSFLDNFEWAWGYSKRFGIVHINYETQERTPKQSALWFKQMMAKNGF 454 >5GNX-A nrPDB Length = 467 Score = 510 bits (1313), Expect = e-144, Method: Composition-based stats. Identities = 138/457 (30%), Positives = 211/457 (46%), Gaps = 37/457 (8%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDL 138 FP+ F WG T A Q+EGS DG G SIWD F HT K+ + + + D Y +D+ Sbjct: 14 FPEGFLWGAATAAYQIEGSSMADGAGESIWDRFSHTPGNMKDGDTGDVACDHYNRWREDI 73 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + + + Y+FS+SW R+ P G + N KGL +Y L+D L+ IEP+ TLYHWDL Sbjct: 74 ELMKRLNLQAYRFSVSWSRVIPQGRGAI-NPKGLAFYDRLVDGLLEAGIEPLATLYHWDL 132 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P AL ++ GGW N I D F DY F+ F RVK W TI+ P+++ GY G APG Sbjct: 133 PAALDDR-GGWLNPDIADWFADYGQVLFEKFKGRVKTWGTINQPWVIVDGGYLHGALAPG 191 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + AV GHN+++AH FR +G + I L P S+ D Sbjct: 192 HRSAYEAV-IAGHNVLRAHGAAVR----RFREVGEGQIGIVLNIEPKYP-ASDKPEDEAA 245 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNN 378 +++ + WF +P+ G G YPE + + F + + + D+ ++ Sbjct: 246 RRRAEAQMNRWFLDPLMGRG-YPEELTDVYGAAWREFPKEDFELIAEPTDWMGLNWYTRA 304 Query: 379 FKPLNTMA----------------KMGQNV-SLNLREALNWIKLEY-NNPRILIAENGWF 420 A + G V L + L W+ + +++ ENG Sbjct: 305 VPENAPDAWPTRSRPVRQTQHAHTETGWEVYPPALTDTLVWLSEQTGGKLPLMVTENGSA 364 Query: 421 TDSR-----VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIR 475 + D ++ ++ + + AI + + GY AWSLLD EW Y+ R Sbjct: 365 WYDPPHAIDGRIHDPMRVHYLQTHIKALHDAIG-KGVDLRGYMAWSLLDNLEWSLGYSKR 423 Query: 476 RGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKE 512 G+ +V+F + +ER K S Y ++I+ +G L Sbjct: 424 FGIVHVNFAT--QERTIKDSGLLYAEVIKTHGDVLNT 458 Score = 450 bits (1157), Expect = e-126, Method: Composition-based stats. Identities = 114/474 (24%), Positives = 192/474 (40%), Gaps = 60/474 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WG + + E + + + +W+ + + +G T C + Sbjct: 13 RFPEGFLWGAATAAYQIEGSSMADGAGES---IWDRFSHTPGNMKDG---DTGDVACDHY 66 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ +E++ R+ + YRF++ W+ V+P G A+N + L +Y +V L+ GI + Sbjct: 67 NRWREDIELMKRLNLQAYRFSVSWSRVIPQGR-GAINPKGLAFYDRLVDGLLEAGIEPLA 125 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP L GWLNP A+ F Y + F++ VK W TIN+P + D Sbjct: 126 TLY-----HWDLPAALDDRGGWLNPDIADWFADYGQVLFEKFKGRVKTWGTINQPWVIVD 180 Query: 700 IYNRSG---------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 G + A HN+L AH A R+FR G + + L+ + PA Sbjct: 181 GGYLHGALAPGHRSAYEAVIAGHNVLRAHGAAV----RRFREVGEGQIGIVLNIEPKYPA 236 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + + A R WF +PL G YP + + + R + + Sbjct: 237 SDKPE-DEAARRRAEAQMNRWFLDPLMGRG-YPEELTDVYGAAWR---------EFPKED 285 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 L+ D+ LN +T + E + R ++ Q + T V P + Sbjct: 286 FELIAEPTDWMGLNWYTR--AVPENAPDAWPTRSRPVRQTQ---HAHTETGWEVYPPALT 340 Query: 871 KLLRWVRR-NYGDMDIYITASG---IDDQALED----DRLRKYYLGKYLQEVLKAYLIDK 922 L W+ G + + +T +G D D D +R +YL +++ + A + Sbjct: 341 DTLVWLSEQTGGKLPLMVTENGSAWYDPPHAIDGRIHDPMRVHYLQTHIKALHDA-IGKG 399 Query: 923 VRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRG 966 V ++GY A+ L + RFG +F K S Y +VI + G Sbjct: 400 VDLRGYMAWSLLDNLEWSLGYSKRFGIVHVNFATQERTIKDSGLLYAEVIKTHG 453 >5DT5-A nrPDB Length = 471 Score = 504 bits (1298), Expect = e-143, Method: Composition-based stats. Identities = 137/457 (29%), Positives = 207/457 (45%), Gaps = 34/457 (7%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVS--STNGSSDSYIFLEKDL 138 F NF +G T + Q+EG+ + G+ PSIWD F T K + + + D Y E+D+ Sbjct: 26 FAPNFVFGTATSSYQIEGAHDEGGRTPSIWDTFCDTDGKVFEKHNGDVACDHYHRFEEDI 85 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +GV Y+FSI+WPR+FP N +G+ +Y TL L I+P VTLYHWDL Sbjct: 86 QHIKQLGVDTYRFSIAWPRIFPS--KGQFNPEGMAFYKTLATRLQEEGIKPAVTLYHWDL 143 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P+ E+ GGW N +D F D+A CF+ V WIT + P+ + Y G HAPG Sbjct: 144 PMWAHEE-GGWVNRDSVDWFLDFARVCFEELDGIVDSWITHNEPWCAGFLSYHLGQHAPG 202 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 AV V H+++ +H K F + ITL ++++ D Sbjct: 203 HTDMNEAVRAV-HHMLLSHGKAVEMLKGEFNSAT--PIGITLNLAPKY-AKTDSINDQIA 258 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRK---KLFSVLPIFSEAEKHEMRGTADFFAFSFG 375 + WF +PI G YP M K + + DFF +F Sbjct: 259 MNNADGYANRWFLDPIF-KGQYPVDMMNLFSKYVHTYDFIHAGDLATISTPCDFFGINFY 317 Query: 376 PNNFKPLNTMAK--------------MGQNVSLN-LREALNWIKLEYNNPRILIAENGWF 420 N + + MG +++ + ++ + ++ EY + I I ENG Sbjct: 318 SRNLVEFSAASDFLHKDAYSDYDKTGMGWDIAPSEFKDLIRRLRAEYTDLPIYITENGAA 377 Query: 421 TDSR---VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRG 477 D + K D I + L V + + + + GY WSLLD FEW Y R G Sbjct: 378 FDDQLVDGKIHDQNRIDYVAQHLQAVSD-LNDEGMNIAGYYLWSLLDNFEWSFGYDKRFG 436 Query: 478 LFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKEST 514 + YVDF++ +ER K SAH+Y +I+ + +L + Sbjct: 437 IIYVDFDT--QERIWKDSAHWYANVIQTHKAALPQEA 471 Score = 440 bits (1133), Expect = e-123, Method: Composition-based stats. Identities = 103/476 (21%), Positives = 184/476 (38%), Gaps = 55/476 (11%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +F +F +G S + E + +W+ + E C + Sbjct: 25 KFAPNFVFGTATSSYQIEGAHDEGGRTPS---IWDTFCDTDGKVFE---KHNGDVACDHY 78 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 ++ ++ + ++ V YRF++ W + P + N + + +Y+ + + + GI V Sbjct: 79 HRFEEDIQHIKQLGVDTYRFSIAWPRIFP--SKGQFNPEGMAFYKTLATRLQEEGIKPAV 136 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP GW+N + + F +A +CF+EL +V WIT NEP Sbjct: 137 TLY-----HWDLPMWAHEEGGWVNRDSVDWFLDFARVCFEELDGIVDSWITHNEPWCAGF 191 Query: 700 IYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 + G G A H++L++H A + +F + ++L+L +A+ Sbjct: 192 LSYHLGQHAPGHTDMNEAVRAVHHMLLSHGKAVEMLKGEFNSATPIGITLNLAPKYAKTD 251 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + A + WF +P+FK G YP M + + + Sbjct: 252 SINDQI---AMNNADGYANRWFLDPIFK-GQYPVDMMNLFSK------YVHTYDFIHAGD 301 Query: 811 RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVR 870 + DF +N ++ V + + + +D D + + P + Sbjct: 302 LATISTPCDFFGINFYSRNLV---EFSAASDFLHKDAYSDYD----KTGMGWDIAPSEFK 354 Query: 871 KLLRWVRRNYGDMDIYITASG--IDDQALE---DDRLRKYYLGKYLQEVLKAYLIDKVRI 925 L+R +R Y D+ IYIT +G DDQ ++ D+ R Y+ ++LQ V + + I Sbjct: 355 DLIRRLRAEYTDLPIYITENGAAFDDQLVDGKIHDQNRIDYVAQHLQAV-SDLNDEGMNI 413 Query: 926 KGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPFEN 971 GYY + L + RFG DF K S +Y VI + Sbjct: 414 AGYYLWSLLDNFEWSFGYDKRFGIIYVDFDTQERIWKDSAHWYANVIQTHKAALPQ 469 >5CG0-A nrPDB Length = 489 Score = 503 bits (1295), Expect = e-142, Method: Composition-based stats. Identities = 152/473 (32%), Positives = 232/473 (49%), Gaps = 46/473 (9%) Query: 77 LYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNV---SSTNGSSDSYIF 133 FP +F +G T + Q+EG+W +DGKG +IWD+ +H + + S+ + ++DSY Sbjct: 1 QQRRFPDDFLFGTATASYQIEGAWDEDGKGENIWDYMVHNTPEVIRDLSNGDIAADSYHN 60 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTL 193 ++D+ + +G+ Y+FS+SW R+ P G+ N G+ +Y+ +D ++ NI P++TL Sbjct: 61 YKRDVEMMRELGLDAYRFSLSWARILPTGMANEVNPAGIAFYNNYIDEMLKYNITPLITL 120 Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTG 253 YHWDLP LQE GG+ N I D F DYA F+ FGDRVK +IT + P + + GYG+ Sbjct: 121 YHWDLPQKLQE-LGGFANPLISDWFEDYARVVFENFGDRVKMFITFNEPREICFEGYGSA 179 Query: 254 MHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENT 313 AP Y NL+ AH+K ++ Y+ FRP Q G IT+ +W P + Sbjct: 180 TKAPILNATAMGAYLCAKNLVTAHAKAYYLYDREFRPVQGGQCGITISVNWFGP-ATPTP 238 Query: 314 MDIFKCQQSMVSVLGWFANPIHG-DGDYPEGMRKKL----------FSVLPIFSEAEKHE 362 D + G +A+PI +G +P+ + K+ +S LP F+E EK Sbjct: 239 EDEMAAELRRQGEWGIYAHPIFSAEGGFPKELSDKIAEKSAQQGYPWSRLPEFTEEEKAF 298 Query: 363 MRGTADFFAFSFGPNNFKPLN------TMAKMGQNVSLN--------------------- 395 +RGT+DFF + + + +V Sbjct: 299 VRGTSDFFGVNHYTAFLVSATERKGPYPVPSLLDDVDTGSWADDSWLKSASAWLTLAPNS 358 Query: 396 LREALNWIKLEYNNPRILIAENGWFTDSRVKTE--DTTAIYMMKNFLSQVLQAIRLDEIR 453 + AL + YN P I ENGW TD + D I + + +L + D I Sbjct: 359 IHTALTHLNNLYNKPVFYITENGWSTDESRENSLIDDDRIQYYRASMESLLNCLD-DGIN 417 Query: 454 VFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 + GY AWSL+D FEW + Y R GL+ VDF+ + R P+ +A YK II+ Sbjct: 418 LKGYMAWSLMDNFEWMEGYIERFGLYEVDFSDPARTRTPRKAAFVYKHIIKHR 470 Score = 448 bits (1152), Expect = e-126, Method: Composition-based stats. Identities = 136/486 (27%), Positives = 210/486 (43%), Gaps = 45/486 (9%) Query: 518 QGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCT 577 Q +FP DF +G + + E + +W+ + + L Sbjct: 2 QRRFPDDFLFGTATASYQIEGAWDEDGKGE---NIWDYMVHNTPEVIR--DLSNGDIAAD 56 Query: 578 DFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637 + N K+ +EM+ + + YRF+L WA +LPTG + VN + +Y + E LK I+ Sbjct: 57 SYHNYKRDVEMMRELGLDAYRFSLSWARILPTGMANEVNPAGIAFYNNYIDEMLKYNITP 116 Query: 638 MVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697 ++TLY H LP+ L G+ NP ++ F+ YA + F+ GD VK++IT NEP + Sbjct: 117 LITLY-----HWDLPQKLQELGGFANPLISDWFEDYARVVFENFGDRVKMFITFNEPREI 171 Query: 698 SDIYNRSGND----------TYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747 S Y A NL+ AHA A+ LYDR+FRP Q G +++ +W Sbjct: 172 CFEGYGSATKAPILNATAMGAYLCAKNLVTAHAKAYYLYDREFRPVQGGQCGITISVNWF 231 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKH-RRGLSSSALPR 805 PA P + AAE Q E +A P+F G +P + + IA K ++G S LP Sbjct: 232 GPATPTPEDEM-AAELRRQGEWGIYAHPIFSAEGGFPKELSDKIAEKSAQQGYPWSRLPE 290 Query: 806 LTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRY----DSDRDIQFLQDITRLSSPTR 861 TE E+ ++GT DF +NH+T V + G D D D + L S + Sbjct: 291 FTEEEKAFVRGTSDFFGVNHYTAFLVSATERKGPYPVPSLLDDVDTGSWADDSWLKSASA 350 Query: 862 L-AVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALED----DRLRKYYLGKYLQEVLK 916 + P + L + Y YIT +G + D R Y ++ +L Sbjct: 351 WLTLAPNSIHTALTHLNNLYNKPVFYITENGWSTDESRENSLIDDDRIQYYRASMESLLN 410 Query: 917 AYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFK-------AKSSIQFYNKVISS 964 L D + +KGY A+ L + RFG + DF + + Y +I Sbjct: 411 -CLDDGINLKGYMAWSLMDNFEWMEGYIERFGLYEVDFSDPARTRTPRKAAFVYKHIIKH 469 Query: 965 RGFPFE 970 R +E Sbjct: 470 RVVDYE 475 >5NS7-A nrPDB Length = 454 Score = 499 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 138/445 (31%), Positives = 209/445 (46%), Gaps = 34/445 (7%) Query: 83 KNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDLSA 140 F WG+ T + Q+EG+ + G+GPSIWD F N + + + D Y +DL Sbjct: 21 DMFTWGVSTSSYQIEGAANQGGRGPSIWDTFSKIPGAVANGDNGDVACDHYHRYNEDLDL 80 Query: 141 LDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPL 200 + ++GV Y+FSI+WPR+ P G N +G+ +Y L+D + R I P TLYHWDLP Sbjct: 81 MKWLGVGAYRFSIAWPRVIPSGYGA-LNKEGMDFYDRLIDGALERGITPWPTLYHWDLPQ 139 Query: 201 ALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEK 260 +LQ+K GGW N F +Y+ + F DR+K WITI+ P+ AW G+ G+ APG K Sbjct: 140 SLQDK-GGWNNRDCAYWFAEYSQKMAEAFSDRLKNWITINEPFCSAWLGHLYGVMAPGIK 198 Query: 261 GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQ 320 +L H+L+ H + + ITL E++ D + Sbjct: 199 -DLKTGINASHHLLLGHGLATKAIRE---VSSELKVGITLNFTPAI-TLGESSEDKLAVE 253 Query: 321 QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFK 380 + WF +P+ YPE + K +PI + + D+ ++ Sbjct: 254 LADGFDNRWFGDPVF-KAKYPEDIVKAFGKEVPI-HPGDMEIISTPLDYLGLNYYFRQTV 311 Query: 381 PLNTMAK----------------MGQNV-SLNLREALNWIKLEYNNPRILIAENGWFTDS 423 + AK MG V + + E L + EY I I ENG D Sbjct: 312 EYDATAKPLPYKQVTAPNVERTGMGWEVHAQSFTELLERVSKEYKPKEIFITENGSAWDD 371 Query: 424 RV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFY 480 V K +D + ++ L + A + + + GY AWSL+D FEW Y R G+ Y Sbjct: 372 EVVDGKVDDPNRVSYLERHLDAMFAA-KNKGVPISGYFAWSLIDNFEWAYGYAKRFGIIY 430 Query: 481 VDFNSKQKERKPKSSAHYYKQIIRE 505 VD+ +++ R PKSSA+YY++ I+E Sbjct: 431 VDYQTQK--RIPKSSAYYYQKRIKE 453 Score = 435 bits (1120), Expect = e-122, Method: Composition-based stats. Identities = 109/463 (23%), Positives = 187/463 (40%), Gaps = 57/463 (12%) Query: 525 FSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKK 584 F+WGV+ S + E A+ +W+ G C + + Sbjct: 23 FTWGVSTSSYQIEGAANQGGRGPS---IWDTFSKIPGAVANG---DNGDVACDHYHRYNE 76 Query: 585 QLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYP 644 L+++ + V YRF++ W V+P+G A+N++ + +Y ++ L+ GI+ TLY Sbjct: 77 DLDLMKWLGVGAYRFSIAWPRVIPSG-YGALNKEGMDFYDRLIDGALERGITPWPTLY-- 133 Query: 645 THAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRS 704 H LP+ L GW N A F Y+ + D +K WITINEP + + + Sbjct: 134 ---HWDLPQSLQDKGGWNNRDCAYWFAEYSQKMAEAFSDRLKNWITINEPFCSAWLGHLY 190 Query: 705 GNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYAD 755 G G A+H+LL+ H LA + S V ++L+ A ++ Sbjct: 191 GVMAPGIKDLKTGINASHHLLLGHGLATKAIRE---VSSELKVGITLNFTPAITLGESSE 247 Query: 756 SHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLK 815 A E F+ WF +P+FK YP + + + + + ++ Sbjct: 248 -DKLAVELADGFDNRWFGDPVFKA-KYPEDIVKAFGKE----------VPIHPGDMEIIS 295 Query: 816 GTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRW 875 +D+ LN++ + V ++ A + + + V +LL Sbjct: 296 TPLDYLGLNYYFRQTVEYDATAKP-----LPYKQVTAPNVERTGMGWEVHAQSFTELLER 350 Query: 876 VRRNYGDMDIYITASGI--DDQALE---DDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYA 930 V + Y +I+IT +G DD+ ++ DD R YL ++L + A V I GY+A Sbjct: 351 VSKEYKPKEIFITENGSAWDDEVVDGKVDDPNRVSYLERHLDAMF-AAKNKGVPISGYFA 409 Query: 931 FKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 + L + RFG D++ KSS +Y K I Sbjct: 410 WSLIDNFEWAYGYAKRFGIIYVDYQTQKRIPKSSAYYYQKRIK 452 >3W53-A nrPDB Length = 506 Score = 495 bits (1274), Expect = e-140, Method: Composition-based stats. Identities = 137/471 (29%), Positives = 195/471 (41%), Gaps = 56/471 (11%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTN--GSSDSYIFLEKD 137 +PK F WG T A Q+EG+ GK S+WD F N + D Y +D Sbjct: 44 AWPKEFLWGSATAAAQIEGAGHSYGKEDSVWDAFARKEGAIAGGENLEVAVDHYHRYRED 103 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + +G+ Y+FS SW R+ P G N +GL +YS L+D L+ I P +TLYHWD Sbjct: 104 VQLMRELGLDSYRFSTSWARVVPGGRT--VNPEGLDFYSRLVDELLENGILPWLTLYHWD 161 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP AL+E+ GGW N F +YA + GDRVK+W T + P + GY G HAP Sbjct: 162 LPQALEER-GGWTNRETSYKFLEYAETVHEKLGDRVKHWTTFNEPLCSSLIGYAAGEHAP 220 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G + A H+ AH R + ITL PN + +D+ Sbjct: 221 GRQEP-QAALAAVHHQHLAHGLA----TARLRELGAEHIGITLNLTNAVPNNPGDPVDLE 275 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKL--FSVLPIFSEAEKHEMRGTADFFAFSFG 375 ++ + +P+ G YPE + + + + + + + DF + Sbjct: 276 AARRVDALWNRMYLDPVL-RGSYPEDLLEDVQGLGLAEVIEAGDLEIISQPIDFLGVNHY 334 Query: 376 --------------PNNFKPLN--------------------TMAKMGQNV-SLNLREAL 400 P P + MG V LR L Sbjct: 335 HDDNVSGHPLPAGQPQPVVPTDSPKSSPFVGSEYVTFPARDLPRTAMGWEVNPEGLRVLL 394 Query: 401 NWIKLEYNN-PRILIAENGWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 N + +Y N P + I ENG V ED + N L V++AI D + V Sbjct: 395 NRLNQDYANLPSLYITENGASYTDTVTEAGTVEDPEREEYILNHLDAVVRAI-ADGVDVR 453 Query: 456 GYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 GY WSLLD FEW Y R G+ +VD+ + + R K+S Y +I N Sbjct: 454 GYFVWSLLDNFEWAWGYAKRFGIIHVDYQT--QVRTIKNSGKAYAGLIAAN 502 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 113/484 (23%), Positives = 192/484 (39%), Gaps = 65/484 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 +P +F WG + + E S D VW+A + G L+ + Sbjct: 45 WPKEFLWGSATAAAQIEGAGHSYGKEDS---VWDAFARKEGAIAGGENLE---VAVDHYH 98 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ ++++ + + YRF+ WA V+P G VN + L +Y +V E L+ GI +T Sbjct: 99 RYREDVQLMRELGLDSYRFSTSWARVVPGGRT--VNPEGLDFYSRLVDELLENGILPWLT 156 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 LY H LP+ L GW N T+ F YA ++LGD VK W T NEP S I Sbjct: 157 LY-----HWDLPQALEERGGWTNRETSYKFLEYAETVHEKLGDRVKHWTTFNEPLCSSLI 211 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 +G G A H+ +AH LA + ++L+ A P N Sbjct: 212 GYAAGEHAPGRQEPQAALAAVHHQHLAHGLATARLRELGAEH----IGITLNLTNAVPNN 267 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 P AA R + +P+ + G YP + E + + + + Sbjct: 268 PGDPVDLEAARRVDALWNRMYLDPVLR-GSYPEDLLEDVQGLGLAEV-------IEAGDL 319 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSP------------ 859 ++ +DF +NH+ V L + + + S Sbjct: 320 EIISQPIDFLGVNHYHDDNVSGHPLPAGQPQPVVPTDSPKSSPFVGSEYVTFPARDLPRT 379 Query: 860 -TRLAVIPWGVRKLLRWVRRNYGDMD-IYITASGID------DQALEDDRLRKYYLGKYL 911 V P G+R LL + ++Y ++ +YIT +G + +D R+ Y+ +L Sbjct: 380 AMGWEVNPEGLRVLLNRLNQDYANLPSLYITENGASYTDTVTEAGTVEDPEREEYILNHL 439 Query: 912 QEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKV 961 V++A + D V ++GY+ + L + RFG D++ K+S + Y + Sbjct: 440 DAVVRA-IADGVDVRGYFVWSLLDNFEWAWGYAKRFGIIHVDYQTQVRTIKNSGKAYAGL 498 Query: 962 ISSR 965 I++ Sbjct: 499 IAAN 502 >1GNX-A nrPDB Length = 479 Score = 487 bits (1254), Expect = e-137, Method: Composition-based stats. Identities = 135/467 (28%), Positives = 206/467 (44%), Gaps = 51/467 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKD 137 TFP+ F WG T + Q+EG+ +DG+ PSIWD + T + N + + ++D Y +D Sbjct: 17 TFPEGFLWGSATASYQIEGAAAEDGRTPSIWDTYARTPGRVRNGDTGDVATDHYHRWRED 76 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + +G+ Y+FS++WPR+ P G A KGL +Y L D L+ + I+P+ TLYHWD Sbjct: 77 VALMAELGLGAYRFSLAWPRIQPTGRG-PALQKGLDFYRRLADELLAKGIQPVATLYHWD 135 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP L+ GGW + F +YA GDRVK W T++ P+ A+ GYG+G+HAP Sbjct: 136 LPQELENA-GGWPERATAERFAEYAAIAADALGDRVKTWTTLNEPWCSAFLGYGSGVHAP 194 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G + A H+L H S+TL H + P +++ D Sbjct: 195 GRTDPV-AALRAAHHLNLGHGLAVQALRDRLPA--DAQCSVTLNIHHVRP-LTDSDADAD 250 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLP--IFSEAEKHEMRGTADFFAFSFG 375 ++ F P+ G YPE + K + + + DF ++ Sbjct: 251 AVRRIDALANRVFTGPML-QGAYPEDLVKDTAGLTDWSFVRDGDLRLAHQKLDFLGVNYY 309 Query: 376 --------------------------------PNNFKPLNTMAKMGQNVSL-NLREALNW 402 +P MG V L E L Sbjct: 310 SPTLVSEADGSGTHNSDGHGRSAHSPWPGADRVAFHQPPGETTAMGWAVDPSGLYELLRR 369 Query: 403 IKLEYNNPRILIAENGWFT----DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYT 458 + ++ ++I ENG D D I +++ L+ V +AI+ D V GY Sbjct: 370 LSSDFPALPLVITENGAAFHDYADPEGNVNDPERIAYVRDHLAAVHRAIK-DGSDVRGYF 428 Query: 459 AWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRE 505 WSLLD FEW Y+ R G YVD+ + R PK+SA +Y ++ R Sbjct: 429 LWSLLDNFEWAHGYSKRFGAVYVDYPTGT--RIPKASARWYAEVART 473 Score = 456 bits (1173), Expect = e-128, Method: Composition-based stats. Identities = 120/493 (24%), Positives = 202/493 (40%), Gaps = 62/493 (12%) Query: 513 STPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTR 572 + PD FP F WG + + E A+ + +W+ G T Sbjct: 10 TAPDAALTFPEGFLWGSATASYQIEGAAAEDGRTPS---IWDTYARTPGRVRNG---DTG 63 Query: 573 PAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLK 632 + ++ + ++A + + YRF+L W + PTG A+ ++ L +YR + E L Sbjct: 64 DVATDHYHRWREDVALMAELGLGAYRFSLAWPRIQPTGRGPAL-QKGLDFYRRLADELLA 122 Query: 633 LGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITIN 692 GI + TLY H LP+ L +A GW +TAE F YA + LGD VK W T+N Sbjct: 123 KGIQPVATLY-----HWDLPQELENAGGWPERATAERFAEYAAIAADALGDRVKTWTTLN 177 Query: 693 EPNRLSDIYNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLH 743 EP + + SG G AAH+L + H LA + + S++L+ Sbjct: 178 EPWCSAFLGYGSGVHAPGRTDPVAALRAAHHLNLGHGLAVQALRDRLPA--DAQCSVTLN 235 Query: 744 ADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSAL 803 P +D+ A R F P+ + G YP + + GL+ + Sbjct: 236 IHHVRPLTD-SDADADAVRRIDALANRVFTGPMLQ-GAYPEDLVK-----DTAGLTDWSF 288 Query: 804 PRLTEAERRLLKGTVDFCALNHFTTRFVM------------HEQLAGSRYDSDRDIQFLQ 851 R + + RL +DF +N+++ V H + A S + + F Q Sbjct: 289 VR--DGDLRLAHQKLDFLGVNYYSPTLVSEADGSGTHNSDGHGRSAHSPWPGADRVAFHQ 346 Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKY 905 ++ AV P G+ +LLR + ++ + + IT +G D + +D R Sbjct: 347 PPGE-TTAMGWAVDPSGLYELLRRLSSDFPALPLVITENGAAFHDYADPEGNVNDPERIA 405 Query: 906 YLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSI 955 Y+ +L V +A + D ++GY+ + L + RFG D+ K+S Sbjct: 406 YVRDHLAAVHRA-IKDGSDVRGYFLWSLLDNFEWAHGYSKRFGAVYVDYPTGTRIPKASA 464 Query: 956 QFYNKVISSRGFP 968 ++Y +V + P Sbjct: 465 RWYAEVARTGVLP 477 >4ZEN-A nrPDB Length = 485 Score = 483 bits (1244), Expect = e-136, Method: Composition-based stats. Identities = 144/480 (30%), Positives = 222/480 (46%), Gaps = 58/480 (12%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKD 137 FP F WG + A QVEG+W +DGKG S+WD F + ++ + + D Y ++D Sbjct: 15 PFPPEFLWGAASAAYQVEGAWNEDGKGLSVWDVFAKQPGRTFKGTNGDVAVDHYHRYQED 74 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 ++ + +G+ Y+FS+SW R+FPDG V N KGL +Y L++ L IEPIVTLYHWD Sbjct: 75 VALMAEMGLKAYRFSVSWSRVFPDGNGAV-NEKGLDFYDRLIEELRNHGIEPIVTLYHWD 133 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 +P AL + YG W++ IID F+ YA FQ FGDRVKYW+T++ + GY G+H P Sbjct: 134 VPQALMDAYGAWESRRIIDDFDRYAVTLFQRFGDRVKYWVTLNEQNIFISFGYRLGLHPP 193 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317 G K ++ +Y H A++KV ++ H+ P G + + + P S ++ Sbjct: 194 GVK-DMKRMYEANHIANLANAKVIQSFR-HYVP--DGKIGPSFAYSPMYPYDS-RPENVL 248 Query: 318 KCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS--VLPIFSEAEKHEMRGTA-DFFAFSF 374 + + W+ + ++ G YP+ L S + P + + ++ DF ++ Sbjct: 249 AFENAEEFQNHWWMD-VYAWGMYPQAAWNYLESQGLEPTVAPGDWELLQAAKPDFMGVNY 307 Query: 375 GPNNFKPLNTMAKMGQNV-------------------------------------SLNLR 397 N +G+ V + LR Sbjct: 308 YQTTTVEHNPPDGVGEGVMNTTGKKGTSTSSGIPGLFKTVRNPHVDTTNWDWAIDPVGLR 367 Query: 398 EALNWIKLEYNNPRILIAENGWFTDSRVK----TEDTTAIYMMKNFLSQVLQAIRLDEIR 453 L I Y P ILI ENG ++ D I ++ + ++ +AI D + Sbjct: 368 IGLRRIANRYQLP-ILITENGLGEFDTLEPGDIVNDDYRIDYLRRHVQEIQRAIT-DGVD 425 Query: 454 VFGYTAWSLLDGFEWQDAYTIRRGLFYV---DFNSKQKERKPKSSAHYYKQIIRENGFSL 510 V GY AWS D W + Y R G YV D + K R K S ++Y+++I NG L Sbjct: 426 VLGYCAWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKKSFYWYQRVIETNGAEL 485 Score = 433 bits (1115), Expect = e-121, Method: Composition-based stats. Identities = 116/495 (23%), Positives = 197/495 (39%), Gaps = 73/495 (14%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP +F WG + + E + L VW+ + +G + Sbjct: 16 FPPEFLWGAASAAYQVEGAWNEDGKG---LSVWDVFAKQPGRTFKGT---NGDVAVDHYH 69 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ + ++A M + YRF++ W+ V P GN AVN + L +Y ++ E GI +VT Sbjct: 70 RYQEDVALMAEMGLKAYRFSVSWSRVFPDGN-GAVNEKGLDFYDRLIEELRNHGIEPIVT 128 Query: 641 LYYPTHAHLGLPEPLLHADG-WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 LY H +P+ L+ A G W + + F YA FQ GD VK W+T+NE N Sbjct: 129 LY-----HWDVPQALMDAYGAWESRRIIDDFDRYAVTLFQRFGDRVKYWVTLNEQNIFIS 183 Query: 700 IYNRSGNDT---------YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 R G Y A H +A+A + + G + S P Sbjct: 184 FGYRLGLHPPGVKDMKRMYEANHIANLANAKVIQSFRHYVP---DGKIGPSFAYSPMYPY 240 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + + + A E +F+ W+ + ++ G YP A Y+ S+ P + + Sbjct: 241 DSRPE-NVLAFENAEEFQNHWWMD-VYAWGMYPQAAWNYLESQGLE-------PTVAPGD 291 Query: 811 RRLLK-GTVDFCALNHFTTRFVMHEQLA-------------GSRYDSDRDIQF--LQDIT 854 LL+ DF +N++ T V H G+ S F +++ Sbjct: 292 WELLQAAKPDFMGVNYYQTTTVEHNPPDGVGEGVMNTTGKKGTSTSSGIPGLFKTVRNPH 351 Query: 855 RLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDD------QALEDDRLRKYYLG 908 ++ A+ P G+R LR + Y + I IT +G+ + + +D R YL Sbjct: 352 VDTTNWDWAIDPVGLRIGLRRIANRY-QLPILITENGLGEFDTLEPGDIVNDDYRIDYLR 410 Query: 909 KYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFK----------AKS 953 +++QE+ +A + D V + GY A+ + + R+GF + K Sbjct: 411 RHVQEIQRA-ITDGVDVLGYCAWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKK 469 Query: 954 SIQFYNKVISSRGFP 968 S +Y +VI + G Sbjct: 470 SFYWYQRVIETNGAE 484 >5YHS-A nrPDB Length = 475 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 138/476 (28%), Positives = 218/476 (45%), Gaps = 55/476 (11%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDL 138 FP +F +G + + QVEG+W +DGKG + WD F K N ++ + + D Y ++D+ Sbjct: 3 FPHDFLFGAASASYQVEGAWNEDGKGVTNWDEFSKIPGKTYNGTNGDIAVDHYHRYKEDV 62 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 + +G+ Y+FSISW R+ P G V N KG+++Y+ L+D + I P VTLYHWDL Sbjct: 63 RLMAEMGLESYRFSISWARILPTGDGKV-NEKGIEFYNNLIDECLKYGIVPFVTLYHWDL 121 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 PL L+ K GGW N + F YA CF+ FGDRVK+WIT + + GY G H PG Sbjct: 122 PLPLE-KDGGWTNKRTAEAFVKYAETCFKAFGDRVKHWITFNETVMFCGLGYLKGAHPPG 180 Query: 259 EKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFK 318 + ++ + H + AH+K Y + Q G + IT + +I Sbjct: 181 IQNDVPKYFQATHYVFYAHAKTVAVYK---QLKQYGEIGITHVFLPAYSVD-DQKENIQA 236 Query: 319 CQQSMVSVLGWFANPIHGDGDYPEGMRKKLFS--VLPIFSEAEKHEMRGTA---DFFAFS 373 + W+ +PI G+YP + ++L P ++ E ++ A DF + Sbjct: 237 ANHANEYETYWYYDPIL-KGEYPSYVVQQLKEKGWTPNWTVEELEIIKQNAEENDFIGLN 295 Query: 374 FG--------------------PNNFKPLNT---------------MAKMGQNVSL-NLR 397 + + P N K G +S Sbjct: 296 YYQPIRVERYDMDIKSEEHSRENSTLAPGNPSFDGFYRTVKMDDKTYTKWGWEISPEGFL 355 Query: 398 EALNWIKLEYNNPRILIAENGWFTDSRV---KTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454 E L+ +K Y + ++ + ENG + + + D I ++ L + +AI + I + Sbjct: 356 EGLHMLKARYGDIKMYVTENGLGDEDPIIDGEIVDVPRIKFIEAHLKVMKRAIE-EGINL 414 Query: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 GY AWS++D W + Y + G +VD N K RK K S H+YK+++ G L Sbjct: 415 KGYYAWSVIDLLSWLNGYKKQYGFIFVDHNDNLK-RKKKLSFHWYKRVVETRGEEL 469 Score = 437 bits (1123), Expect = e-122, Method: Composition-based stats. Identities = 117/490 (23%), Positives = 202/490 (41%), Gaps = 68/490 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP DF +G + + E + + W+ G + Sbjct: 2 KFPHDFLFGAASASYQVEGAWNEDGKGVTN---WDEFSKIPGKTYNGT---NGDIAVDHY 55 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 K+ + ++A M + YRF++ WA +LPTG+ VN + + +Y ++ E LK GI V Sbjct: 56 HRYKEDVRLMAEMGLESYRFSISWARILPTGD-GKVNEKGIEFYNNLIDECLKYGIVPFV 114 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TLY H LP PL GW N TAEAF YA CF+ GD VK WIT NE Sbjct: 115 TLY-----HWDLPLPLEKDGGWTNKRTAEAFVKYAETCFKAFGDRVKHWITFNETVMFCG 169 Query: 700 IYNRSGNDT----------YGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 + G + A H + AHA +Y + + G + ++ A Sbjct: 170 LGYLKGAHPPGIQNDVPKYFQATHYVFYAHAKTVAVYKQLKQY---GEIGITHVFLPAYS 226 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 + + + +AA ++E W+ +P+ K G+YP+ + + + K P T Sbjct: 227 VDDQKE-NIQAANHANEYETYWYYDPILK-GEYPSYVVQQLKEK-------GWTPNWTVE 277 Query: 810 ERRLLKGTV---DFCALNHFTTRFV----------MHEQLAGSRYDSDRDIQFLQDITRL 856 E ++K DF LN++ V H + + + ++ Sbjct: 278 ELEIIKQNAEENDFIGLNYYQPIRVERYDMDIKSEEHSRENSTLAPGNPSFDGFYRTVKM 337 Query: 857 S----SPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQ-----ALEDDRLRKYYL 907 + + P G + L ++ YGD+ +Y+T +G+ D+ D R ++ Sbjct: 338 DDKTYTKWGWEISPEGFLEGLHMLKARYGDIKMYVTENGLGDEDPIIDGEIVDVPRIKFI 397 Query: 908 GKYLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSD------FKAKSSIQ 956 +L+ + +A + + + +KGYYA+ + + K ++GF D K K S Sbjct: 398 EAHLKVMKRA-IEEGINLKGYYAWSVIDLLSWLNGYKKQYGFIFVDHNDNLKRKKKLSFH 456 Query: 957 FYNKVISSRG 966 +Y +V+ +RG Sbjct: 457 WYKRVVETRG 466 >5WKA-A nrPDB Length = 473 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 145/491 (29%), Positives = 213/491 (43%), Gaps = 73/491 (14%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK--NVSSTNGSSDSYIFLEKDL 138 FP F WG T A Q+EG+ +DG+ PSIWD F T K N + + + D Y E+DL Sbjct: 2 FPDGFVWGTSTAAYQIEGAVAEDGRTPSIWDTFSRTKGKVVNGDTGDVACDHYHRWEEDL 61 Query: 139 SALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDL 198 L +GV Y+FS++WPR+ PD + AN KGL +Y L+D L RNI P+ T+YHWDL Sbjct: 62 DLLAELGVQAYRFSVAWPRIHPD-VTGPANQKGLDFYQRLIDGLRDRNIIPLPTMYHWDL 120 Query: 199 PLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPG 258 P AL+++ GGW F DYA + D + W T + P+ AW GYG G HAPG Sbjct: 121 PQALEDE-GGWIVRDTALRFADYAATVLEKL-DGIDKWTTFNEPWTSAWLGYGYGHHAPG 178 Query: 259 EKG-----NLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENT 313 + H L ++ + + +TL + P +E+ Sbjct: 179 RTDIGAAAAATHHLLLAHGLGVQAARAIRPHVE---------IGLTLNLGVLRPGTTED- 228 Query: 314 MDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSE---AEKHEMRGTADFF 370 D+ ++ + + +P+ G+YP M + P F + + DF Sbjct: 229 QDVEATWRADGNQNRIWLDPLF-KGEYPADMIEHYSRWTPGFHTVQNGDLEIISSPIDFL 287 Query: 371 AFS-FGPNNF----------------------------------KPLNTMAKMGQNVS-L 394 + +GP P MG V Sbjct: 288 GVNFYGPGTVMNVGREDAARAAGFNVGPRPESDEDNHLRCIGVETPGRPKTAMGWEVDAT 347 Query: 395 NLREALNWIKLEYNNPRILIAENGWFTDS----RVKTEDTTAIYMMKNFLSQVLQAIRLD 450 LRE L IK EY + + I ENG +D I + + L L AI D Sbjct: 348 ALRELLVRIKNEYTDIPLYITENGAAYHDYVNASGDVKDPERITYLNDHLEACLGAID-D 406 Query: 451 EIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSL 510 + + GY WSLLD FEW Y+ R G+ ++D+++ + R PK+S +Y+ ++ NG Sbjct: 407 GVNLQGYFIWSLLDNFEWGFGYSRRFGIVWIDYDTGR--RIPKASYRWYQGVVATNGL-- 462 Query: 511 KESTPDVQGQF 521 PD+ G Sbjct: 463 ----PDLDGHL 469 Score = 444 bits (1142), Expect = e-124, Method: Composition-based stats. Identities = 116/488 (23%), Positives = 197/488 (40%), Gaps = 64/488 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP F WG + + + E + + +W+ V G T C + Sbjct: 2 FPDGFVWGTSTAAYQIEGAVAEDGRTPS---IWDTFSRTKGKVVNG---DTGDVACDHYH 55 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 ++ L++LA + V YRF++ W + P N++ L +Y+ ++ I + T Sbjct: 56 RWEEDLDLLAELGVQAYRFSVAWPRIHPDVT-GPANQKGLDFYQRLIDGLRDRNIIPLPT 114 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDI 700 +Y H LP+ L GW+ TA F YA ++L D + W T NEP + + Sbjct: 115 MY-----HWDLPQALEDEGGWIVRDTALRFADYAATVLEKL-DGIDKWTTFNEPWTSAWL 168 Query: 701 YNRSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPAN 751 G+ G A H+LL+AH L + RP + L+L+ P Sbjct: 169 GYGYGHHAPGRTDIGAAAAATHHLLLAHGLGVQAARA-IRPH--VEIGLTLNLGVLRPGT 225 Query: 752 PYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAER 811 D A R + + +PLFK G+YPA M E+ S+ G + + + Sbjct: 226 TE-DQDVEATWRADGNQNRIWLDPLFK-GEYPADMIEHY-SRWTPGFHT-----VQNGDL 277 Query: 812 RLLKGTVDFCALNHFTTRFVMHEQ----------LAGSRYDSDRDIQ----FLQDITRLS 857 ++ +DF +N + VM+ G R +SD D ++ R Sbjct: 278 EIISSPIDFLGVNFYGPGTVMNVGREDAARAAGFNVGPRPESDEDNHLRCIGVETPGRPK 337 Query: 858 SPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASG------IDDQALEDDRLRKYYLGKYL 911 + V +R+LL ++ Y D+ +YIT +G ++ D R YL +L Sbjct: 338 TAMGWEVDATALRELLVRIKNEYTDIPLYITENGAAYHDYVNASGDVKDPERITYLNDHL 397 Query: 912 QEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKV 961 + L A + D V ++GY+ + L + RFG D+ K+S ++Y V Sbjct: 398 EACLGA-IDDGVNLQGYFIWSLLDNFEWGFGYSRRFGIVWIDYDTGRRIPKASYRWYQGV 456 Query: 962 ISSRGFPF 969 +++ G P Sbjct: 457 VATNGLPD 464 >1W9D-M nrPDB Length = 501 Score = 467 bits (1201), Expect = e-131, Method: Composition-based stats. Identities = 144/475 (30%), Positives = 223/475 (46%), Gaps = 64/475 (13%) Query: 88 GIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVS----STNGSSDSYIFLEKDLSALDF 143 G+ + A Q+EG+ G+G +IWD F H + + + + DS+ + +KD+ LD Sbjct: 32 GVASSAYQIEGTI---GRGLNIWDGFTHRYPNKSGPDHGNGDTTCDSFSYWQKDIDVLDE 88 Query: 144 IGVSFYQFSISWPRLFPDGIVT-VANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLAL 202 + + Y+FSI+W R+ P G + N KG+ YY L+ L+ + I P VTL+HWDLP L Sbjct: 89 LNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLFHWDLPQTL 148 Query: 203 QEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGN 262 Q++Y G+ + IID F DYA CF+ FGD VKYW+TI+ Y V GYG+ + APG Sbjct: 149 QDEYEGFLDPQIIDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSP 208 Query: 263 L-----------AAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSE 311 Y V H+ + AH+KV Y ++ HQ G + T+ + W P Sbjct: 209 TVDPSCYAGNSSTEPYIVAHHQLLAHAKVVDLYRKNYT-HQGGKIGPTMITRWFLPYNDT 267 Query: 312 NTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFA 371 + I ++ LGWF P+ +G YP+ M + LP FS E + ++G+ DF Sbjct: 268 DRHSIAATERMKEFFLGWFMGPL-TNGTYPQIMIDTVGERLPSFSPEESNLVKGSYDFLG 326 Query: 372 FSFG--------PNNFKPLNTMAKMGQNV------------------------------S 393 ++ PN N A M Sbjct: 327 LNYYFTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYP 386 Query: 394 LNLREALNWIKLEYNNPRILIAENGWFTDSRVKTE----DTTAIYMMKNFLSQVLQAIRL 449 + +++ K +Y NP I + ENG T D T I + + L + + I+ Sbjct: 387 KGIYSVMDYFKNKYYNPLIYVTENGISTPGDENRNQSMLDYTRIDYLCSHLCFLNKVIKE 446 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504 ++ V GY AW+L D +E+ +T+R GL Y+D+N+ +R K S +Y+ I Sbjct: 447 KDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDWNN-VTDRDLKKSGQWYQSFIS 500 Score = 417 bits (1072), Expect = e-116, Method: Composition-based stats. Identities = 126/492 (25%), Positives = 198/492 (40%), Gaps = 79/492 (16%) Query: 528 GVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLE 587 GV S + E L +W+ +R ++ G C F +K ++ Sbjct: 32 GVASSAYQIEGTI------GRGLNIWDGFTHRYPNK-SGPDHGNGDTTCDSFSYWQKDID 84 Query: 588 MLARMKVTHYRFALDWASVLPTGNLSA-VNRQALRYYRCVVSEGLKLGISAMVTLYYPTH 646 +L + T YRF++ W+ ++P G S VN + + YY ++S +K GI+ VTL+ Sbjct: 85 VLDELNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLF---- 140 Query: 647 AHLGLPEPLLHAD-GWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSG 705 H LP+ L G+L+P + F+ YA LCF+E GD VK W+TIN+ + S Sbjct: 141 -HWDLPQTLQDEYEGFLDPQIIDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSA 199 Query: 706 ---------------------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHA 744 + Y AH+ L+AHA LY + + Q G + ++ Sbjct: 200 LDAPGRCSPTVDPSCYAGNSSTEPYIVAHHQLLAHAKVVDLYRKNYT-HQGGKIGPTMIT 258 Query: 745 DWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALP 804 W P N A ER +F + WF PL G YP M + + + LP Sbjct: 259 RWFLPYNDTDRHSIAATERMKEFFLGWFMGPL-TNGTYPQIMIDTVGER---------LP 308 Query: 805 RLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYD----------------SDRDIQ 848 + E L+KG+ DF LN++ T++ + + S I Sbjct: 309 SFSPEESNLVKGSYDFLGLNYYFTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIG 368 Query: 849 FLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALED------DRL 902 L + + S + P G+ ++ + + Y + IY+T +GI E+ D Sbjct: 369 PLFEKDKADSTDNIYYYPKGIYSVMDYFKNKYYNPLIYVTENGISTPGDENRNQSMLDYT 428 Query: 903 RKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTS------DFKA 951 R YL +L + K V +KGY A+ L + RFG D Sbjct: 429 RIDYLCSHLCFLNKVIKEKDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDWNNVTDRDL 488 Query: 952 KSSIQFYNKVIS 963 K S Q+Y IS Sbjct: 489 KKSGQWYQSFIS 500 >3ZJK-A nrPDB Length = 431 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 137/443 (30%), Positives = 208/443 (46%), Gaps = 40/443 (9%) Query: 83 KNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL--KNVSSTNGSSDSYIFLEKDLSA 140 + F WG+ T A Q+EG+ ++DG+GPSIWD F ++ S+ + D Y E+D++ Sbjct: 6 EKFLWGVATSAYQIEGATQEDGRGPSIWDAFAQRPGAIRDGSTGEPACDHYRRYEEDIAL 65 Query: 141 LDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPL 200 + +GV Y+FS++WPR+ P+G + N KGL +Y L+D L+ I P +TLYHWDLPL Sbjct: 66 MQSLGVRAYRFSVAWPRILPEGRGRI-NPKGLAFYDRLVDRLLASGITPFLTLYHWDLPL 124 Query: 201 ALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEK 260 AL+E+ GGW++ F +YA + DRV ++ T++ P+ A+ G+ TG HAPG + Sbjct: 125 ALEER-GGWRSRETAFAFAEYAEAVARALADRVPFFATLNEPWCSAFLGHWTGEHAPGLR 183 Query: 261 GNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQ 320 NL A H+L+ H + I L P E+ + Sbjct: 184 -NLEAALRAAHHLLLGHGLAVEALR----AAGARRVGIVLN---FAPAYGEDPEAVDVAD 235 Query: 321 QSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG----- 375 + +F +PI G G YPE + +PI S + + DF ++ Sbjct: 236 R---YHNRFFLDPILGKG-YPESPFRDPPP-VPILS-RDLELVARPLDFLGVNYYAPVRV 289 Query: 376 --------PNNFKPLNTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTDS--- 423 P MG V L L + E P + + ENG Sbjct: 290 APGTGTLPVRYLPPEGPATAMGWEVYPEGLHHLLKRLGREVPWP-LYVTENGAAYPDLWT 348 Query: 424 -RVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVD 482 ED + ++ + L+A R + + + GY WSL+D FEW YT R GL+YVD Sbjct: 349 GEAVVEDPERVAYLEAHVEAALRA-REEGVDLRGYFVWSLMDNFEWAFGYTRRSGLYYVD 407 Query: 483 FNSKQKERKPKSSAHYYKQIIRE 505 F + R PK SA +Y++ I Sbjct: 408 F--PSQRRIPKRSALWYRERIAR 428 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 109/466 (23%), Positives = 182/466 (39%), Gaps = 69/466 (14%) Query: 523 CDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNI 582 F WGV S + E +W+A R +G T C + Sbjct: 6 EKFLWGVATSAYQIEGATQEDGRGPS---IWDAFAQRPGAIRDG---STGEPACDHYRRY 59 Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 ++ + ++ + V YRF++ W +LP G +N + L +Y +V L GI+ +TLY Sbjct: 60 EEDIALMQSLGVRAYRFSVAWPRILPEGR-GRINPKGLAFYDRLVDRLLASGITPFLTLY 118 Query: 643 YPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYN 702 H LP L GW + TA AF YA + L D V + T+NEP + + + Sbjct: 119 -----HWDLPLALEERGGWRSRETAFAFAEYAEAVARALADRVPFFATLNEPWCSAFLGH 173 Query: 703 RSGNDTYG---------AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPY 753 +G G AAH+LL+ H LA R + V + L+ A +P Sbjct: 174 WTGEHAPGLRNLEAALRAAHHLLLGHGLAVEA----LRAAGARRVGIVLNFAPAYGEDP- 228 Query: 754 ADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRL 813 A + ++ +F +P+ G YP S R L R + L Sbjct: 229 -----EAVDVADRYHNRFFLDPILGKG-YPE-------SPFRDPPPVPILSR----DLEL 271 Query: 814 LKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLL 873 + +DF +N++ V G+ R + ++ V P G+ LL Sbjct: 272 VARPLDFLGVNYYAPVRV----APGTGTLPVRYL----PPEGPATAMGWEVYPEGLHHLL 323 Query: 874 RWVRRNYGDMDIYITASGID------DQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKG 927 + + R +Y+T +G +A+ +D R YL +++ L+A + V ++G Sbjct: 324 KRLGREV-PWPLYVTENGAAYPDLWTGEAVVEDPERVAYLEAHVEAALRAR-EEGVDLRG 381 Query: 928 YYAFKLAEE-----KSKPRFGFFTSDFK-----AKSSIQFYNKVIS 963 Y+ + L + R G + DF K S +Y + I+ Sbjct: 382 YFVWSLMDNFEWAFGYTRRSGLYYVDFPSQRRIPKRSALWYRERIA 427 >2XHY-A nrPDB Length = 479 Score = 446 bits (1147), Expect = e-125, Method: Composition-based stats. Identities = 124/485 (25%), Positives = 203/485 (41%), Gaps = 56/485 (11%) Query: 75 LFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI---HTHLKNVSS-------- 123 + T PK+F WG A QVEG W K GKGPSI D H + ++ Sbjct: 2 IVKKLTLPKDFLWGGAVAAHQVEGGWNKGGKGPSICDVLTGGAHGVPREITKEVLPGKYY 61 Query: 124 -TNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDAL 182 + + D Y ++D+ +G ++ SI+W R+FP G N +GL++Y + D L Sbjct: 62 PNHEAVDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPKGDEAQPNEEGLKFYDDMFDEL 121 Query: 183 VLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNP 242 + NIEP++TL H+++PL L ++YG W N ++D F +A F+ + +VKYW+T + Sbjct: 122 LKYNIEPVITLSHFEMPLHLVQQYGSWTNRKVVDFFVRFAEVVFERYKHKVKYWMTFNEI 181 Query: 243 -----YLVAWHGY-GTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWL 296 + GY +G+ + +Y V H+ A + P + Sbjct: 182 NNQRNWRAPLFGYCCSGVVYTEHENPEETMYQVLHHQFVASALAVKAAR-RINPEM--KV 238 Query: 297 SITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV--LPI 354 L + P S N D+ Q+SM + + G YP + + Sbjct: 239 GCMLAMVPLYP-YSCNPDDVMFAQESMRE--RYVFTDVQLRGYYPSYVLNEWERRGFNIK 295 Query: 355 FSEAEKHEMR-GTADFFAFSFGPNNF-------------------KPLNTMAKMGQNVSL 394 + + +R GT D+ FS+ N P + G + Sbjct: 296 MEDGDLDVLREGTCDYLGFSYYMTNAVKAEGGTGDAISGFEGSVPNPYVKASDWGWQIDP 355 Query: 395 -NLREALNWIKLEYNNPRILIAENGWFTDSRVK----TEDTTAIYMMKNFLSQVLQAIRL 449 LR AL + Y P + I ENG+ +V+ D I ++ + ++ +A+ Sbjct: 356 VGLRYALCELYERYQRP-LFIVENGFGAYDKVEEDGSINDDYRIDYLRAHIEEMKKAVTY 414 Query: 450 DEIRVFGYTAWSLLDGFEWQDA-YTIRRGLFYV---DFNSKQKERKPKSSAHYYKQIIRE 505 D + + GYT W +D + Y+ R G YV D + R K S ++YK++I Sbjct: 415 DGVDLMGYTPWGCIDCVSFTTGQYSKRYGFIYVNKHDDGTGDMSRSRKKSFNWYKEVIAS 474 Query: 506 NGFSL 510 NG L Sbjct: 475 NGEKL 479 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 96/491 (19%), Positives = 175/491 (35%), Gaps = 65/491 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKT----RPAQ 575 P DF WG + + E + V + + + L Sbjct: 7 TLPKDFLWGGAVAAHQVEGGWNKGGKGPSICDVLTGGAHGVPREITKEVLPGKYYPNHEA 66 Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 + + K+ +++ A M +R ++ W + P G+ + N + L++Y + E LK I Sbjct: 67 VDFYGHYKEDIKLFAEMGFKCFRTSIAWTRIFPKGDEAQPNEEGLKFYDDMFDELLKYNI 126 Query: 636 SAMVTLYYPTHAHLGLPEPLLHADG-WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEP 694 ++TL +H +P L+ G W N + F +A + F+ VK W+T NE Sbjct: 127 EPVITL-----SHFEMPLHLVQQYGSWTNRKVVDFFVRFAEVVFERYKHKVKYWMTFNEI 181 Query: 695 N------------RLSDIYN----RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAV 738 N S + Y H+ VA ALA + R P + Sbjct: 182 NNQRNWRAPLFGYCCSGVVYTEHENPEETMYQVLHHQFVASALAVKAARR-INPEMKVGC 240 Query: 739 SLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL 798 L++ + NP D A E + + + G YP+ + + Sbjct: 241 MLAMVPLYPYSCNP--DDVMFAQESMRE---RYVFTDVQLRGYYPSYVLNEWERRGFNI- 294 Query: 799 SSSALPRLTEAERRLLK-GTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLS 857 ++ + + +L+ GT D+ +++ T V E G + + + Sbjct: 295 ------KMEDGDLDVLREGTCDYLGFSYYMTNAVKAEGGTGDAISGFE--GSVPNPYVKA 346 Query: 858 SPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID------DQALEDDRLRKYYLGKYL 911 S + P G+R L + Y ++I +G + +D R YL ++ Sbjct: 347 SDWGWQIDPVGLRYALCELYERY-QRPLFIVENGFGAYDKVEEDGSINDDYRIDYLRAHI 405 Query: 912 QEVLKAYLIDKVRIKGYYAFKLAE------EKSKPRFGFFTSD----------FKAKSSI 955 +E+ KA D V + GY + + + R+GF + K S Sbjct: 406 EEMKKAVTYDGVDLMGYTPWGCIDCVSFTTGQYSKRYGFIYVNKHDDGTGDMSRSRKKSF 465 Query: 956 QFYNKVISSRG 966 +Y +VI+S G Sbjct: 466 NWYKEVIASNG 476 >4F66-A nrPDB Length = 480 Score = 429 bits (1104), Expect = e-120, Method: Composition-based stats. Identities = 126/481 (26%), Positives = 209/481 (43%), Gaps = 58/481 (12%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI---HTHLKNVSST---------NGSS 128 P+NF WG A Q+EG W++ GKG S+ D H + +++ + + Sbjct: 7 LPENFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITAGVLEGKYYPNHEAI 66 Query: 129 DSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIE 188 D Y ++D+ +G ++ SI+W R+FP G N GLQ+Y L D + IE Sbjct: 67 DFYHHYKEDVKLFAEMGFKCFRTSIAWTRIFPKGDEAEPNEAGLQFYDDLFDECLKYGIE 126 Query: 189 PIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWH 248 P+VTL H++LP L +YGG+ N +ID F +A CF+ + D+VKYW+T + A + Sbjct: 127 PVVTLSHFELPYHLVTEYGGFTNRKVIDFFVHFAEVCFRRYKDKVKYWMTFNEINNQANY 186 Query: 249 G------YGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGS 302 +G+ A +Y H + A ++ + + + Sbjct: 187 QEDFAPFTNSGIVYKEGDDREAIMYQAAHYELVASARAVKIGHAINPNL---NIGCMVAM 243 Query: 303 HWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKK--LFSVLPIFSEAEK 360 I P + N DI Q++M +FA+ +H G YPE + K ++ F+E +K Sbjct: 244 CPIYP-ATCNPKDILMAQKAMQKRY-YFAD-VHVHGFYPEHIFKYWERKAIKVDFTERDK 300 Query: 361 HEM-RGTADFFAFSFGPNNF---------------------KPLNTMAKMGQNVSL-NLR 397 ++ GT D+ FS+ + P + + LR Sbjct: 301 KDLFEGTVDYIGFSYYMSFVIDAHRENNPYYDYLETEDLVKNPYVKASDWDWQIDPQGLR 360 Query: 398 EALNWIKLEYNNPRILIAENGWFTDSRVK----TEDTTAIYMMKNFLSQVLQAIRLDEIR 453 ALNW Y+ P + I ENG+ +V+ D I + + ++++A+ D + Sbjct: 361 YALNWFTDMYHLP-LFIVENGFGAIDQVEADGMVHDDYRIDYLGAHIKEMIKAVDEDGVE 419 Query: 454 VFGYTAWSLLDGFEWQDAYT-IRRGLFYVDFNS---KQKERKPKSSAHYYKQIIRENGFS 509 + GYT W +D R G YVD + +R PK S ++YK++I NG Sbjct: 420 LMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDEGKGTLKRSPKLSFNWYKEVIASNGDD 479 Query: 510 L 510 + Sbjct: 480 I 480 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 114/495 (23%), Positives = 199/495 (40%), Gaps = 63/495 (12%) Query: 516 DVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKT---- 571 + + P +F WG + + E V A + + + L+ Sbjct: 2 NAMSKLPENFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITAGVLEGKYYP 61 Query: 572 RPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGL 631 + + K+ +++ A M +R ++ W + P G+ + N L++Y + E L Sbjct: 62 NHEAIDFYHHYKEDVKLFAEMGFKCFRTSIAWTRIFPKGDEAEPNEAGLQFYDDLFDECL 121 Query: 632 KLGISAMVTLYYPTHAHLGLPEPLL-HADGWLNPSTAEAFQAYAGLCFQELGDLVKLWIT 690 K GI +VTL +H LP L+ G+ N + F +A +CF+ D VK W+T Sbjct: 122 KYGIEPVVTL-----SHFELPYHLVTEYGGFTNRKVIDFFVHFAEVCFRRYKDKVKYWMT 176 Query: 691 INE------------PNRLSDIYNRSGND----TYGAAHNLLVAHALAWRLYDRQFRPSQ 734 NE P S I + G+D Y AAH LVA A A ++ P+ Sbjct: 177 FNEINNQANYQEDFAPFTNSGIVYKEGDDREAIMYQAAHYELVASARAVKI-GHAINPNL 235 Query: 735 RGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKH 794 +++ + NP A++ +Q + +FA+ + G YP + +Y K Sbjct: 236 NIGCMVAMCPIYPATCNP---KDILMAQKAMQ-KRYYFAD-VHVHGFYPEHIFKYWERKA 290 Query: 795 RRGLSSSALPRLTEAE-RRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDI 853 + TE + + L +GTVD+ +++ + + + YD +++ Sbjct: 291 IK-------VDFTERDKKDLFEGTVDYIGFSYYMSFVIDAHRENNPYYDYLETEDLVKNP 343 Query: 854 TRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID--DQALED----DRLRKYYL 907 +S + P G+R L W Y + ++I +G DQ D D R YL Sbjct: 344 YVKASDWDWQIDPQGLRYALNWFTDMY-HLPLFIVENGFGAIDQVEADGMVHDDYRIDYL 402 Query: 908 GKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS------KPRFGFFTSD----------FKA 951 G +++E++KA D V + GY + + S + R+GF D Sbjct: 403 GAHIKEMIKAVDEDGVELMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDEGKGTLKRSP 462 Query: 952 KSSIQFYNKVISSRG 966 K S +Y +VI+S G Sbjct: 463 KLSFNWYKEVIASNG 477 >4IPN-B nrPDB Length = 487 Score = 421 bits (1082), Expect = e-117, Method: Composition-based stats. Identities = 127/474 (26%), Positives = 203/474 (42%), Gaps = 52/474 (10%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSST-------NGSSDSYIF 133 FP +F WG A QVEG++ +DGKG S+ D L + D Y Sbjct: 20 FPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEATENPTEDNLKLIGIDFYHK 79 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTL 193 ++D+S +G + ++ SI+W R+FP G N GL+YY L D L IEP+VTL Sbjct: 80 YKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGLKYYDELFDELHAHGIEPLVTL 139 Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGT- 252 H++ PL L KY GW + +I + +A + + D+VKYW+T + V + + Sbjct: 140 SHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYKDKVKYWLTFNEVNSVLELPFTSG 199 Query: 253 GMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSEN 312 G+ P E + +Y H+ + A S V + G + + + ++ + P N Sbjct: 200 GIDIPKENLSKQELYQAIHHELVASSLVTKIAREINSEFKVGCMVLAMPAYPMTP----N 255 Query: 313 TMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLF--SVLPIFSEAEKHEMR-GTADF 369 D++ + L + + +H G YP ++ + F+ + ++ T DF Sbjct: 256 PKDVWATHEYE--NLNYLFSDVHVRGYYPNYAKRYFKENDINIEFAAEDAELLKNYTVDF 313 Query: 370 FAFSFG--------PNNF------------KPLNTMAKMGQNVSL-NLREALNWIKLEYN 408 +FS+ P + P ++ G + LR LN Y Sbjct: 314 LSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESSEWGWQIDPIGLRIILNRYYDRYQ 373 Query: 409 NPRILIAENGWFTDSR--------VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460 + I ENG + + +D I MK L QV +A++ D + + GYT+W Sbjct: 374 -IPLFIVENGLGAKDQLIKDELNNLTVQDDYRIQYMKEHLLQVAEALQ-DGVEIMGYTSW 431 Query: 461 SLLDGFEWQDAY-TIRRGLFYVDFNS---KQKERKPKSSAHYYKQIIRENGFSL 510 +D A + R GL YVD N R K S +YK++I NG SL Sbjct: 432 GCIDCVSMSTAQLSKRYGLIYVDRNDDGSGTLNRYKKMSFTWYKEVIESNGESL 485 Score = 377 bits (968), Expect = e-104, Method: Composition-based stats. Identities = 108/493 (21%), Positives = 188/493 (38%), Gaps = 77/493 (15%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSD------PHLYVWNATGNRLLHRVEGVRLKTRPA 574 FP DF WG + + E + P + AT N ++ + + Sbjct: 20 FPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEATENPTEDNLKLIGI----- 74 Query: 575 QCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLG 634 + K+ + + + M +R ++ W+ + P G+ N L+YY + E G Sbjct: 75 --DFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGLKYYDELFDELHAHG 132 Query: 635 ISAMVTLYYPTHAHLGLPEPL-LHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINE 693 I +VTL +H P L GW++ ++ +A + D VK W+T NE Sbjct: 133 IEPLVTL-----SHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYKDKVKYWLTFNE 187 Query: 694 PNRLSDIYNRSG-----------NDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSL 742 N + ++ SG + Y A H+ LVA +L ++ + G + L++ Sbjct: 188 VNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREINSEFKVGCMVLAM 247 Query: 743 HADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSA 802 A P P W E + F++ + G YP + Y + Sbjct: 248 P---AYPMTPNPKDVWATHE--YENLNYLFSD-VHVRGYYPNYAKRYFKE-------NDI 294 Query: 803 LPRLTEAERRLLKG-TVDFCALNHFTTRFVMHEQLAGSRYDSDRD--IQFLQDITRLSSP 859 + LLK TVDF + +++ + + ++Y+S I L + SS Sbjct: 295 NIEFAAEDAELLKNYTVDFLSFSYYMSVT---QSALPTQYNSGEGNIIGGLVNPYLESSE 351 Query: 860 TRLAVIPWGVRKLLRWVRRNYGDMDIYITASGID--DQALED--------DRLRKYYLGK 909 + P G+R +L Y + ++I +G+ DQ ++D D R Y+ + Sbjct: 352 WGWQIDPIGLRIILNRYYDRY-QIPLFIVENGLGAKDQLIKDELNNLTVQDDYRIQYMKE 410 Query: 910 YLQEVLKAYLIDKVRIKGYYAFKLAEEKS------KPRFGFFTSDFK----------AKS 953 +L +V +A L D V I GY ++ + S R+G D K Sbjct: 411 HLLQVAEA-LQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGSGTLNRYKKM 469 Query: 954 SIQFYNKVISSRG 966 S +Y +VI S G Sbjct: 470 SFTWYKEVIESNG 482 >1PBG-A nrPDB Length = 468 Score = 418 bits (1075), Expect = e-117, Method: Composition-based stats. Identities = 128/480 (26%), Positives = 200/480 (41%), Gaps = 59/480 (12%) Query: 77 LYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEK 136 + T PK+F +G T A Q EG+ DGKGP WD ++ + + +SD Y Sbjct: 1 MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEP--ASDFYHKYPV 58 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 DL + GV+ + SI+W R+FP G V N KG+++Y L R++EP VTL+H+ Sbjct: 59 DLELAEEYGVNGIRISIAWSRIFPTGYGEV-NEKGVEFYHKLFAECHKRHVEPFVTLHHF 117 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 D P AL G + N I+ F DYA +CF+ F + V YW T + + Y G Sbjct: 118 DTPEALHSN-GDFLNRENIEHFIDYAAFCFEEFPE-VNYWTTFNEIGPIGDGQYLVGKFP 175 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 PG K +LA V+ HN++ +H++ Y KG + + P EN D+ Sbjct: 176 PGIKYDLAKVFQSHHNMMVSHARAVKLYKDK---GYKGEIGVVHALPTKYPYDPENPADV 232 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPI------FSEAEKHEM---RGTA 367 + + + + + G Y + + + +L + + + + Sbjct: 233 RAAELEDIIHNKFILDATYL-GHYSDKTMEGVNHILAENGGELDLRDEDFQALDAAKDLN 291 Query: 368 DFFAFSFGPNNF---------------------------------KPLNTMAKMGQNVSL 394 DF ++ +++ + Sbjct: 292 DFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRVAPDYVPRTDWDWIIYP 351 Query: 395 -NLREALNWIKLEYNN-PRILIAENGWFTDSR---VKTEDTTAIYMMKNFLSQVLQAIRL 449 L + + +K +Y N +I I ENG D I +K L + AI Sbjct: 352 EGLYDQIMRVKNDYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVKQHLEVLSDAI-A 410 Query: 450 DEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFS 509 D V GY WSL+D F W + Y R GLFYVDF++ +ER PK SAH+YK++ Sbjct: 411 DGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDT--QERYPKKSAHWYKKLAETQVIE 468 Score = 374 bits (960), Expect = e-103, Method: Composition-based stats. Identities = 103/489 (21%), Positives = 183/489 (37%), Gaps = 64/489 (13%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 P DF +G + + E + W+ +E T + Sbjct: 4 TLPKDFIFGGATAAYQAEGATHTDGKGPV---AWDKY-------LEDNYWYTAEPASDFY 53 Query: 580 VNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMV 639 LE+ V R ++ W+ + PTG VN + + +Y + +E K + V Sbjct: 54 HKYPVDLELAEEYGVNGIRISIAWSRIFPTG-YGEVNEKGVEFYHKLFAECHKRHVEPFV 112 Query: 640 TLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 TL+ H PE L +LN E F YA CF+E + V W T NE + D Sbjct: 113 TLH-----HFDTPEALHSNGDFLNRENIEHFIDYAAFCFEEFPE-VNYWTTFNEIGPIGD 166 Query: 700 IYNRSGN----------DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEP 749 G + + HN++V+HA A +LY + +G + + P Sbjct: 167 GQYLVGKFPPGIKYDLAKVFQSHHNMMVSHARAVKLYKDK---GYKGEIGVVHALPTKYP 223 Query: 750 ANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 +P + RAAE + + + G Y E + H + L E Sbjct: 224 YDPENPADVRAAELEDIIHNKFILDATY-LGHYSDKTMEGVN--HILAENGGELDLRDED 280 Query: 810 ERRL--LKGTVDFCALNHFTTRFVMH-----EQLAGSRYDSDRDIQFLQDITR------- 855 + L K DF +N++ + ++ E + + + ++ + R Sbjct: 281 FQALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRVAPDYV 340 Query: 856 LSSPTRLAVIPWGVRKLLRWVRRNYGD-MDIYITASGID--DQALED---DRLRKYYLGK 909 + + P G+ + V+ +Y + IYIT +G+ D+ +++ D R Y+ + Sbjct: 341 PRTDWDWIIYPEGLYDQIMRVKNDYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVKQ 400 Query: 910 YLQEVLKAYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSDFKA-----KSSIQFYN 959 +L EVL + D +KGY+ + L + + R+G F DF K S +Y Sbjct: 401 HL-EVLSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDTQERYPKKSAHWYK 459 Query: 960 KVISSRGFP 968 K+ ++ Sbjct: 460 KLAETQVIE 468 >4GZE-A nrPDB Length = 481 Score = 417 bits (1073), Expect = e-116, Method: Composition-based stats. Identities = 123/489 (25%), Positives = 206/489 (42%), Gaps = 56/489 (11%) Query: 71 NESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFI---HTHLKNVSSTNGS 127 + + FP+ F WG A Q+EG +K+ GKG S D + + ++ + Sbjct: 1 SNAMTIKGRAFPEGFLWGGAVAAHQLEGGYKEGGKGLSTADIMTLGTNERPREITDGVVA 60 Query: 128 S---------DSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTL 178 D Y +D+ +G ++ SI+W R+FP+G + N GLQ+Y L Sbjct: 61 GKYYPNHQAIDFYHRYPEDIELFAEMGFKCFRTSIAWTRIFPNGDESEPNEAGLQFYDDL 120 Query: 179 LDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWIT 238 D + I+P+VTL H+++P L ++YGGW+N +I + ++A CF+ + D+V YW+T Sbjct: 121 FDECLKNGIQPVVTLAHFEMPYHLVKQYGGWRNRKLIQFYLNFAKVCFERYRDKVTYWMT 180 Query: 239 IHNPYLVAWHG------YGTG-MHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 291 + +G +H PGE Y H + A + + Sbjct: 181 FNEINNQTNFESDGAMLTDSGIIHQPGENRERWM-YQAAHYELVASAAAVQLGHQINPDF 239 Query: 292 QKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSV 351 Q + + I P + D+ Q++M + +FA+ +H +G YP+ +R + S Sbjct: 240 Q---IGCMIAMCPIYP-LTAAPADVLFAQRAMQTRF-YFAD-VHCNGTYPQWLRNRFESE 293 Query: 352 ---LPIFSEAEKHEMRGTADFFAFSFGPNNF-----------------KPLNTMAKMGQN 391 L I +E K GT D+ FS+ + P + G Sbjct: 294 HFNLDITAEDLKILQAGTVDYIGFSYYMSFTVKDTGKLAYNEEHDLVKNPYVKASDWGWQ 353 Query: 392 VSL-NLREALNWIKLEYNNPRILIAENGWFTDSR----VKTEDTTAIYMMKNFLSQVLQA 446 V LR A+NW Y+ P + I ENG + + D I + + L Q+ A Sbjct: 354 VDPVGLRYAMNWFTDRYHLP-LFIVENGLGAIDKKTADNQIHDDYRIDYLTDHLRQIKLA 412 Query: 447 IRLDEIRVFGYTAWSLLDGFEWQDAY-TIRRGLFYVDFNS---KQKERKPKSSAHYYKQI 502 + D + + GYT W +D + R G YVD N +R K S +++ + Sbjct: 413 VLEDGVDLIGYTPWGCIDLVAASTGQMSKRYGFIYVDENDDGSGSLKRYKKDSFTWFQHV 472 Query: 503 IRENGFSLK 511 I NG ++ Sbjct: 473 IATNGAEIE 481 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 114/493 (23%), Positives = 190/493 (38%), Gaps = 65/493 (13%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWN-ATGNRLLHRVEGVRLKT---RPAQC 576 FP F WG + + E + T R +GV Sbjct: 11 FPEGFLWGGAVAAHQLEGGYKEGGKGLSTADIMTLGTNERPREITDGVVAGKYYPNHQAI 70 Query: 577 TDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS 636 + + +E+ A M +R ++ W + P G+ S N L++Y + E LK GI Sbjct: 71 DFYHRYPEDIELFAEMGFKCFRTSIAWTRIFPNGDESEPNEAGLQFYDDLFDECLKNGIQ 130 Query: 637 AMVTLYYPTHAHLGLPEPL-LHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 +VTL AH +P L GW N + + +A +CF+ D V W+T NE N Sbjct: 131 PVVTL-----AHFEMPYHLVKQYGGWRNRKLIQFYLNFAKVCFERYRDKVTYWMTFNEIN 185 Query: 696 RL------------SDIYNRSGND----TYGAAHNLLVAHALAWRLYDRQFRPSQRGAVS 739 S I ++ G + Y AAH LVA A A +L Q P + Sbjct: 186 NQTNFESDGAMLTDSGIIHQPGENRERWMYQAAHYELVASAAAVQL-GHQINPDFQIGCM 244 Query: 740 LSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLS 799 +++ + A P + A+R +Q +FA+ + G YP +R S+H Sbjct: 245 IAMCPIYPLTAAP---ADVLFAQRAMQTRF-YFAD-VHCNGTYPQWLRNRFESEHFN--- 296 Query: 800 SSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSP 859 L E + L GTVD+ +++ + V + + + +++ +S Sbjct: 297 ---LDITAEDLKILQAGTVDYIGFSYYMSFTVKDT----GKLAYNEEHDLVKNPYVKASD 349 Query: 860 TRLAVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALED---DRLRKYYLGKYLQE 913 V P G+R + W Y + ++I +G ID + ++ D R YL +L++ Sbjct: 350 WGWQVDPVGLRYAMNWFTDRY-HLPLFIVENGLGAIDKKTADNQIHDDYRIDYLTDHLRQ 408 Query: 914 VLKAYLIDKVRIKGYYAFKLAE------EKSKPRFGFFTSDFK----------AKSSIQF 957 + A L D V + GY + + + R+GF D K S + Sbjct: 409 IKLAVLEDGVDLIGYTPWGCIDLVAASTGQMSKRYGFIYVDENDDGSGSLKRYKKDSFTW 468 Query: 958 YNKVISSRGFPFE 970 + VI++ G E Sbjct: 469 FQHVIATNGAEIE 481 >5NAV-A nrPDB Length = 477 Score = 416 bits (1070), Expect = e-116, Method: Composition-based stats. Identities = 119/468 (25%), Positives = 206/468 (44%), Gaps = 50/468 (10%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSST---NGSSDSYIFLEKD 137 FP+ F WG T Q EG++ K + +++D++ T + + + +S+ Y + D Sbjct: 20 FPEGFVWGAATSGPQTEGNFHKQHQ--NVFDYWFATEPEQFDAGVGPDTASNFYNDYDHD 77 Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 L+ + GV + SI W RL D NA G+ +Y+ ++D+++ +I P + L+H+D Sbjct: 78 LALMAQAGVQGLRTSIQWTRLIDDFETASLNADGVAFYNHVIDSMLAHHITPYINLHHFD 137 Query: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257 LP+AL +KY GW++ ++++F +A CF++FGDRV +W T + P +V Y G H P Sbjct: 138 LPVALYDKYHGWESKHVVELFVKFAEQCFKLFGDRVDHWYTFNEPKVVVDGQYLYGWHYP 197 Query: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNT-HFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 AV V +N+ A +K ++ RP Q + I L S++ D+ Sbjct: 198 QVINGPKAV-QVAYNMNLASAKTVARFHELSVRPEQ--QIGIILNLTPAY-AASDDPADL 253 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKL--FSVLPIFSEAEKHEMRG-TADFFAFS 373 + + + F +P G +PE + ++L VL + E + D + Sbjct: 254 AAAEFAELWSNNLFLDPAVL-GHFPEKLVERLTMDGVLWDATPTELAIIAANPVDSLGVN 312 Query: 374 FG-----------PNNFKPLNTM--------------AKMGQNVSLN-LREALNWIKLEY 407 + P + +P G + + + I+ Y Sbjct: 313 YYHPFRVQRPDISPKSLQPWMPDIYFKEYDMPGRMMNVDRGWEIYPQAMTDIARNIQKNY 372 Query: 408 NNPRILIAENGW-------FTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460 N +I+ENG F D + +D I MK L+ + + I GY W Sbjct: 373 GNIPWMISENGMGVAGEERFLDKQGVVQDDYRIDFMKEHLTALAKGIAA-GSNCQGYFVW 431 Query: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF 508 S +D + W AY R GL D +++ K K SA ++ ++ NGF Sbjct: 432 SGIDCWSWNHAYHNRYGLIRNDIHTQTK--TLKKSAKWFAELGERNGF 477 Score = 353 bits (907), Expect = 2e-97, Method: Composition-based stats. Identities = 94/484 (19%), Positives = 174/484 (35%), Gaps = 61/484 (12%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP F WG S + E F H V++ E P ++F Sbjct: 19 EFPEGFVWGAATSGPQTEG-----NFHKQHQNVFDYWFAT---EPEQFDAGVGPDTASNF 70 Query: 580 VN-IKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAM 638 N L ++A+ V R ++ W ++ +++N + +Y V+ L I+ Sbjct: 71 YNDYDHDLALMAQAGVQGLRTSIQWTRLIDDFETASLNADGVAFYNHVIDSMLAHHITPY 130 Query: 639 VTLYYPTHAHLGLPEPLLHA-DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697 + L+ H LP L GW + E F +A CF+ GD V W T NEP + Sbjct: 131 INLH-----HFDLPVALYDKYHGWESKHVVELFVKFAEQCFKLFGDRVDHWYTFNEPKVV 185 Query: 698 SDIYNRSGND---------TYGAAHNLLVAHALAWRLYDR-QFRPSQRGAVSLSLHADWA 747 D G A+N+ +A A + RP Q+ + L+L +A Sbjct: 186 VDGQYLYGWHYPQVINGPKAVQVAYNMNLASAKTVARFHELSVRPEQQIGIILNLTPAYA 245 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT 807 +P + AAE + F +P G +P + E + L T Sbjct: 246 ASDDP---ADLAAAEFAELWSNNLFLDPAV-LGHFPEKLVERL-------TMDGVLWDAT 294 Query: 808 EAERRLL-KGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPT----RL 862 E ++ VD +N++ V ++ + ++ Sbjct: 295 PTELAIIAANPVDSLGVNYYHPFRVQRPDISPKSLQPWMPDIYFKEYDMPGRMMNVDRGW 354 Query: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASGI---------DDQALEDDRLRKYYLGKYLQE 913 + P + + R +++NYG++ I+ +G+ D Q + D R ++ ++L Sbjct: 355 EIYPQAMTDIARNIQKNYGNIPWMISENGMGVAGEERFLDKQGVVQDDYRIDFMKEHLTA 414 Query: 914 VLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVIS 963 + K + +GY+ + + R+G +D K S +++ ++ Sbjct: 415 LAK-GIAAGSNCQGYFVWSGIDCWSWNHAYHNRYGLIRNDIHTQTKTLKKSAKWFAELGE 473 Query: 964 SRGF 967 GF Sbjct: 474 RNGF 477 >4B3K-A nrPDB Length = 479 Score = 408 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 119/466 (25%), Positives = 202/466 (43%), Gaps = 47/466 (10%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLK---NVSSTNGSSDSYIFLEK 136 FPK F+WG T Q EG + K + +++D++ + + +SD+Y +E Sbjct: 2 AFPKEFWWGGATSGPQSEGRFAKQHR--NLFDYWYEEEPDLFYDYVGPDTASDAYHQIES 59 Query: 137 DLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW 196 DL+ L +G + Y+ SI W RL D N GL YY+ ++DA + I P++ L+H+ Sbjct: 60 DLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRVIDACLANGIRPVINLHHF 119 Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHA 256 DLP+AL + YGGW++ ++D+F ++ CF+ FGDRVK W + P +V Y H Sbjct: 120 DLPIALYQAYGGWESKHVVDLFVAFSKVCFEQFGDRVKDWFVHNEPMVVVEGSYLMQFHY 179 Query: 257 PGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDI 316 P AV V +NL A +KV Y G + L P S++ D+ Sbjct: 180 PAIVDGKKAV-QVAYNLALATAKVIQAYRRGPAELSDGRIGTILNLTPAYP-ASQSEADM 237 Query: 317 FKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIF--SEAEKHEMRGT-ADFFAFS 373 + + F G +PE + L ++ + E + D+ + Sbjct: 238 AAAHFAELWNNDLFMEAA-VHGKFPEELVAVLKKDGVLWQSTPEELALIAENRVDYLGLN 296 Query: 374 FG-------PNNFKPLNTM------------------AKMGQNVSL-NLREALNWIKLEY 407 F P+ ++ G + + + ++ Y Sbjct: 297 FYHPKRVKAPDAIPVISPSWSPEWYYDPYLMPGRRMNVDKGWEIYPEAVYDIAIKMRDHY 356 Query: 408 NNPRILIAENGWFT-------DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460 +N ++ENG D + +D I +K L+ + + I FGY W Sbjct: 357 DNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTYLHKGIEA-GSNCFGYHVW 415 Query: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIREN 506 + +DG+ W +AY R GL V+ N + R+PK+SA+++K++ N Sbjct: 416 TPIDGWSWLNAYKNRYGL--VENNIHTQVRRPKASAYWFKKVATHN 459 Score = 348 bits (892), Expect = 1e-95, Method: Composition-based stats. Identities = 95/490 (19%), Positives = 174/490 (35%), Gaps = 56/490 (11%) Query: 521 FPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFV 580 FP +F WG S + E + + W L + G + Sbjct: 3 FPKEFWWGGATSGPQSEGRFAKQHRN--LFDYWYEEEPDLFYDYVG-----PDTASDAYH 55 Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 I+ L +LA + YR ++ W ++ + +N L YY V+ L GI ++ Sbjct: 56 QIESDLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRVIDACLANGIRPVIN 115 Query: 641 LYYPTHAHLGLPEPL-LHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSD 699 L+ H LP L GW + + F A++ +CF++ GD VK W NEP + + Sbjct: 116 LH-----HFDLPIALYQAYGGWESKHVVDLFVAFSKVCFEQFGDRVKDWFVHNEPMVVVE 170 Query: 700 IYNR---------SGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPA 750 G A+NL +A A + Y R G + L+ A PA Sbjct: 171 GSYLMQFHYPAIVDGKKAVQVAYNLALATAKVIQAYRRGPAELSDGRIGTILNLTPAYPA 230 Query: 751 NPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAE 810 + +++ AA + F E G +P + + L + T E Sbjct: 231 SQ-SEADMAAAHFAELWNNDLFMEAAV-HGKFPEELVAVLKK-------DGVLWQSTPEE 281 Query: 811 RRLLK-GTVDFCALNHFTTRFVMHEQ----LAGSRYDSDRDIQFLQDITRLSSPTRLAVI 865 L+ VD+ LN + + V ++ S +L R++ + Sbjct: 282 LALIAENRVDYLGLNFYHPKRVKAPDAIPVISPSWSPEWYYDPYLMPGRRMNVDKGWEIY 341 Query: 866 PWGVRKLLRWVRRNYGDMDIYITASGI---------DDQALEDDRLRKYYLGKYLQEVLK 916 P V + +R +Y ++ +++ +G+ D+ D R +L ++L + K Sbjct: 342 PEAVYDIAIKMRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTYLHK 401 Query: 917 AYLIDKVRIKGYYAFKLAE-----EKSKPRFGFFTSD-----FKAKSSIQFYNKVISSRG 966 + GY+ + + K R+G ++ + K+S ++ KV + Sbjct: 402 -GIEAGSNCFGYHVWTPIDGWSWLNAYKNRYGLVENNIHTQVRRPKASAYWFKKVATHNR 460 Query: 967 FPFENSSSRC 976 Sbjct: 461 LISLEVMEEF 470 >1VFF-A nrPDB Length = 423 Score = 367 bits (942), Expect = e-101, Method: Composition-based stats. Identities = 111/441 (25%), Positives = 190/441 (43%), Gaps = 44/441 (9%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG-SSDSYIFLEKDLS 139 FP+ F +G T + Q+EG+ + + D + + + + +G + + + D+ Sbjct: 5 FPEMFLFGTATSSHQIEGNNRWN-------DWWYYEQIGKLPYRSGKACNHWELYRDDIQ 57 Query: 140 ALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLP 199 + +G + Y+FSI W RLFP+ N Y ++D L+ R I P+VTL+H+ P Sbjct: 58 LMTSLGYNAYRFSIEWSRLFPE--ENKFNEDAFMKYREIIDLLLTRGITPLVTLHHFTSP 115 Query: 200 LALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGE 259 L +K GG+ + + + Y ++ ++VK T + P + GY T P Sbjct: 116 LWFMKK-GGFLREENLKHWEKYIEKVAELL-EKVKLVATFNEPMVYVMMGYLTAYWPPFI 173 Query: 260 KGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKC 319 + A + V NL+KAH+ + + F+ + I L + S+ D Sbjct: 174 RSPFKA-FKVAANLLKAHAIAYELLHGKFKVGIVKNIPIILPA-------SDKERDRKAA 225 Query: 320 QQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAE--------KHEMRGTADFFA 371 +++ F + I G Y G+ K +P S+A+ E+R T + Sbjct: 226 EKADNLFNWHFLDAIWS-GKY-RGVFKTY--RIPQ-SDADFIGVNYYTASEVRHTWNPLK 280 Query: 372 FSFGPNNFKPLNTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDT 430 F F +MG +V + AL Y P + I ENG T +D Sbjct: 281 FFFEVKLADISERKTQMGWSVYPKGIYMALKK-ASRYGRP-LYITENGIAT-----LDDE 333 Query: 431 TAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKER 490 + + L V +AI D + V GY WS +D +EW++ + R GL VD+ + ER Sbjct: 334 WRVEFIIQHLQYVHKAIE-DGLDVRGYFYWSFMDNYEWKEGFGPRFGLVEVDYQT--FER 390 Query: 491 KPKSSAHYYKQIIRENGFSLK 511 +P+ SA+ Y +I R + Sbjct: 391 RPRKSAYVYGEIARSKEIKDE 411 Score = 339 bits (871), Expect = 3e-93, Method: Composition-based stats. Identities = 101/483 (20%), Positives = 178/483 (36%), Gaps = 82/483 (16%) Query: 517 VQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQC 576 + +FP F +G S + E + W G C Sbjct: 1 MPLKFPEMFLFGTATSSHQIEG--------NNRWNDWWYYEQI------GKLPYRSGKAC 46 Query: 577 TDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS 636 + + ++++ + YRF+++W+ + P + N A YR ++ L GI+ Sbjct: 47 NHWELYRDDIQLMTSLGYNAYRFSIEWSRLFPE--ENKFNEDAFMKYREIIDLLLTRGIT 104 Query: 637 AMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 +VTL+ H P + G+L + ++ Y + L + VKL T NEP Sbjct: 105 PLVTLH-----HFTSPLWFMKKGGFLREENLKHWEKYIEKVAE-LLEKVKLVATFNEPMV 158 Query: 697 LSDIYN---------RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747 + RS + A NLL AHA+A+ L +F+ + + L A Sbjct: 159 YVMMGYLTAYWPPFIRSPFKAFKVAANLLKAHAIAYELLHGKFKVGIVKNIPIILPAS-- 216 Query: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLT 807 + +AAE+ F + + S RG+ + Sbjct: 217 -----DKERDRKAAEKADNLFNWHFLDAI--------------WSGKYRGVFKTY----- 252 Query: 808 EAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPW 867 R+ + DF +N++T V H + + L DI+ + +V P Sbjct: 253 ----RIPQSDADFIGVNYYTASEVRHTWNPLKFFFEVK----LADISERKTQMGWSVYPK 304 Query: 868 GVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKG 927 G+ L+ YG +YIT +GI A DD R ++ ++LQ V KA + D + ++G Sbjct: 305 GIYMALKKAS-RYG-RPLYITENGI---ATLDDEWRVEFIIQHLQYVHKA-IEDGLDVRG 358 Query: 928 YYAFKLAEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPFENSSSRCS 977 Y+ + + PRFG D++ + S Y ++ S+ E R Sbjct: 359 YFYWSFMDNYEWKEGFGPRFGLVEVDYQTFERRPRKSAYVYGEIARSKEIKDE-LLKRYG 417 Query: 978 QTQ 980 + Sbjct: 418 LPE 420 >4HA4-A nrPDB Length = 489 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 107/503 (21%), Positives = 185/503 (36%), Gaps = 79/503 (15%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDS-------YI 132 TFPK+F +G Q E S W ++H +N+++ S D + Sbjct: 3 TFPKDFLFGWSQAGFQSEMGTPGSEDPNSDWYAWVHDR-ENIAAGLVSGDFPENGPGYWG 61 Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTV-------------------------- 166 K A +G++ + + W R+FP V Sbjct: 62 NYRKFHDAAQAMGLTAARIGVEWSRIFPRPTFDVKVDAEVKGDDVLSVYVSEGALEQLDK 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYG----------GWKNDTII 215 AN + +Y + L R I I+ LYHW LPL L + GW + + Sbjct: 122 MANRDAINHYREMFSDLRSRGITFILNLYHWPLPLWLHDPIAIRRGNLSAPSGWLDVRTV 181 Query: 216 DIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGT--GMHAPGEKGNLAAVYTVGHNL 273 F ++ Y D V + T++ P +V GY PG L NL Sbjct: 182 IEFAKFSAYVAWKLDDLVYMYSTMNEPNVVWGLGYAAVKSGFPPGY-LCLECAGRAMKNL 240 Query: 274 IKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGW-FAN 332 ++AH++ + + K + + + P D +++ W F + Sbjct: 241 VQAHARAYDA----VKAITKKPVGVIYANSDFTPL---TDADREAAERAK-FDNRWAFFD 292 Query: 333 PIH---GDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG----PNNFKPLN-T 384 + G + ++ +L + + + RG+ +G PN P Sbjct: 293 AVVRGQLGGSTRDDLKGRLDWIGVNYYTRQVVRARGSGYEIVPGYGHGCEPNGVSPAGRP 352 Query: 385 MAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQV 443 + G L L Y+ P +L+ ENG + D Y + + + QV Sbjct: 353 CSDFGWEFYPEGLYNVLKEYWDRYHLP-LLVTENGIADEG-----DYQRPYYLVSHVYQV 406 Query: 444 LQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503 +A++ D + V GY WSL D +EW ++ R GL VD+++K+ +P SA Y++I Sbjct: 407 HRALQ-DGVNVIGYLHWSLADNYEWASGFSKRFGLLMVDYSTKRLHWRP--SAFIYREIA 463 Query: 504 RENGFSLK----ESTPDVQGQFP 522 + + + S P ++G P Sbjct: 464 KSRAITDEIEHLNSVPPLRGLSP 486 Score = 354 bits (908), Expect = 1e-97, Method: Composition-based stats. Identities = 111/514 (21%), Positives = 187/514 (36%), Gaps = 108/514 (21%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 FP DF +G +++ + E +P DP+ W A + + G+ P + Sbjct: 3 TFPKDFLFGWSQAGFQSE--MGTPGSEDPNSD-WYAWVHDRENIAAGLVSGDFPENGPGY 59 Query: 580 V-NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA------------------------ 614 N +K + M +T R ++W+ + P Sbjct: 60 WGNYRKFHDAAQAMGLTAARIGVEWSRIFPRPTFDVKVDAEVKGDDVLSVYVSEGALEQL 119 Query: 615 ---VNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA-----------DG 660 NR A+ +YR + S+ GI+ ++ LY H LP L G Sbjct: 120 DKMANRDAINHYREMFSDLRSRGITFILNLY-----HWPLPLWLHDPIAIRRGNLSAPSG 174 Query: 661 WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYG---------- 710 WL+ T F ++ +L DLV ++ T+NEPN + + + + Sbjct: 175 WLDVRTVIEFAKFSAYVAWKLDDLVYMYSTMNEPNVVWGLGYAAVKSGFPPGYLCLECAG 234 Query: 711 -AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEI 769 A NL+ AHA A YD +++ + ++D+ P D+ AAER +F+ Sbjct: 235 RAMKNLVQAHARA---YDAVKAITKKPVGVIYANSDF----TPLTDADREAAERA-KFDN 286 Query: 770 AWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTR 829 W + A +R + R LKG +D+ +N++T + Sbjct: 287 RW--------AFFDAVVRGQLGGSTR----------------DDLKGRLDWIGVNYYTRQ 322 Query: 830 FVMHEQLA---GSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIY 886 V Y + + R S P G+ +L+ Y + + Sbjct: 323 VVRARGSGYEIVPGYGHGCEPNGVSPAGRPCSDFGWEFYPEGLYNVLKEYWDRY-HLPLL 381 Query: 887 ITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPR 941 +T +GI D+ D R YYL ++ +V +A L D V + GY + LA+ R Sbjct: 382 VTENGIADEG---DYQRPYYLVSHVYQVHRA-LQDGVNVIGYLHWSLADNYEWASGFSKR 437 Query: 942 FGFFTSDFKAKS-----SIQFYNKVISSRGFPFE 970 FG D+ K S Y ++ SR E Sbjct: 438 FGLLMVDYSTKRLHWRPSAFIYREIAKSRAITDE 471 >1QVB-A nrPDB Length = 481 Score = 353 bits (905), Expect = 3e-97, Method: Composition-based stats. Identities = 107/490 (21%), Positives = 179/490 (36%), Gaps = 78/490 (15%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDS-------YIF 133 FPK+F G + Q E S W ++H +N ++ S D + Sbjct: 3 FPKDFMIGYSSSPFQFEAGIPGSEDPNSDWWVWVHD-PENTAAGLVSGDFPENGPGYWNL 61 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTV--------------------------- 166 + D + +GV+ + + W R+FP V Sbjct: 62 NQNDHDLAEKLGVNTIRVGVEWSRIFPKPTFNVKVPVERDENGSIVHVDVDDKAVERLDE 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKY-----------GGWKNDTI 214 AN + + +Y + V R + I+ LYHW LPL L GW N+ Sbjct: 122 LANKEAVNHYVEMYKDWVERGRKLILNLYHWPLPLWLHNPIMVRRMGPDRAPSGWLNEES 181 Query: 215 IDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYG--TGMHAPGEKGNLAAVYTVGHN 272 + F YA Y G+ W T++ P +V GY G PG +L A N Sbjct: 182 VVEFAKYAAYIAWKMGELPVMWSTMNEPNVVYEQGYMFVKGGFPPGY-LSLEAADKARRN 240 Query: 273 LIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFAN 332 +I+AH++ + N + K + + W E E ++F +S S L +F + Sbjct: 241 MIQAHARAYDNI----KRFSKKPVGLIYAFQWFE--LLEGPAEVFDKFKS--SKLYYFTD 292 Query: 333 PIHGDG-----DYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFG----PNNFKPL- 382 + +Y + +L + + +++ +G P P Sbjct: 293 IVSKGSSIINVEYRRDLANRLDWLGVNYYSRLVYKIVDDKPIILHGYGFLCTPGGISPAE 352 Query: 383 NTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLS 441 N + G V L L + Y +++ ENG D + + + Sbjct: 353 NPCSDFGWEVYPEGLYLLLKELYNRYGV-DLIVTENGVSDS-----RDALRPAYLVSHVY 406 Query: 442 QVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQ 501 V +A + I V GY WSL D +EW + + GL VDF +K++ +P SA +++ Sbjct: 407 SVWKAAN-EGIPVKGYLHWSLTDNYEWAQGFRQKFGLVMVDFKTKKRYLRP--SALVFRE 463 Query: 502 IIRENGFSLK 511 I NG + Sbjct: 464 IATHNGIPDE 473 Score = 323 bits (829), Expect = 2e-88, Method: Composition-based stats. Identities = 103/516 (19%), Positives = 187/516 (36%), Gaps = 109/516 (21%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 +FP DF G + S + E+ + + +VW + + G+ P + Sbjct: 2 KFPKDFMIGYSSSPFQFEAGIPGSEDPNSDWWVW---VHDPENTAAGLVSGDFPENGPGY 58 Query: 580 VNIKK-QLEMLARMKVTHYRFALDWASVLPTGNLSA------------------------ 614 N+ + ++ ++ V R ++W+ + P + Sbjct: 59 WNLNQNDHDLAEKLGVNTIRVGVEWSRIFPKPTFNVKVPVERDENGSIVHVDVDDKAVER 118 Query: 615 ----VNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHA------------ 658 N++A+ +Y + + ++ G ++ LY H LP L + Sbjct: 119 LDELANKEAVNHYVEMYKDWVERGRKLILNLY-----HWPLPLWLHNPIMVRRMGPDRAP 173 Query: 659 DGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTY--------- 709 GWLN + F YA ++G+L +W T+NEPN + + + Sbjct: 174 SGWLNEESVVEFAKYAAYIAWKMGELPVMWSTMNEPNVVYEQGYMFVKGGFPPGYLSLEA 233 Query: 710 --GAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQF 767 A N++ AHA A YD R S++ V L W E AE F +F Sbjct: 234 ADKARRNMIQAHARA---YDNIKRFSKKP-VGLIYAFQWFELLE-------GPAEVFDKF 282 Query: 768 EIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFT 827 + + L+ D + I ++RR L +D+ +N+++ Sbjct: 283 K----SSKLYYFTDIVSKGSSIINVEYRRD----------------LANRLDWLGVNYYS 322 Query: 828 T---RFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMD 884 + V + + Y + S V P G+ LL+ + YG +D Sbjct: 323 RLVYKIVDDKPIILHGYGFLCTPGGISPAENPCSDFGWEVYPEGLYLLLKELYNRYG-VD 381 Query: 885 IYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSK 939 + +T +G+ D D LR YL ++ V KA + + +KGY + L + + Sbjct: 382 LIVTENGVSDSR---DALRPAYLVSHVYSVWKAA-NEGIPVKGYLHWSLTDNYEWAQGFR 437 Query: 940 PRFGFFTSDFKAKS-----SIQFYNKVISSRGFPFE 970 +FG DFK K S + ++ + G P E Sbjct: 438 QKFGLVMVDFKTKKRYLRPSALVFREIATHNGIPDE 473 >4R27-A nrPDB Length = 434 Score = 341 bits (874), Expect = 1e-93, Method: Composition-based stats. Identities = 103/454 (22%), Positives = 182/454 (40%), Gaps = 42/454 (9%) Query: 76 FLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNG-SSDSYIFL 134 + + FP++F WG+ T QVEG+ S H + +G + D Y Sbjct: 2 PMTNPFPQDFLWGVATAGHQVEGNN-----VNSDVWFLEHLPGTIFAEPSGDAVDHYHRY 56 Query: 135 EKDLSALDFIGVSFYQFSISWPRLFP-DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTL 193 +D++ + +G + Y+FS+ W R+ P +G +VA L +Y +L+A + P+VT Sbjct: 57 REDIALIAGLGFTSYRFSVEWARIEPEEGHFSVA---ALDHYKRVLEACREHGLTPVVTF 113 Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWH-GYGT 252 +H+ PL L + GGW+ + ++F Y GD + T++ P L +G Sbjct: 114 HHFASPLWLL-RSGGWEGERTPELFARYCGRVMAHLGDLIGVACTLNEPNLPWLLESFGI 172 Query: 253 GMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSEN 312 G AP +G + L S V F + G ++ L +H + Sbjct: 173 GGEAPENRGKVPMWAAAAQRLGVDASTVA---PFQFCSTEAG-FNVKLAAH-------KA 221 Query: 313 TMDIFKCQQSMVSVLGWFA-----NPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTA 367 + K + + +GW + G + +R+ + S + + G Sbjct: 222 ATEAIKAHRPDL-RVGWTLANSDIQSVPGGEEIAAQVRRDVNERFLEASRGD--DFVGIQ 278 Query: 368 DFFAFSFGPNNFKPLNT---MAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSR 424 + +GP+ P + +MG+ + EA +++ ENG T+ Sbjct: 279 TYGRTVYGPDGHAPAPEGVAVNQMGEEIYPQALEATIREAWRVAGIPVMVTENGLATED- 337 Query: 425 VKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFN 484 DT + ++ + V + D I V GY AW+ D FEW Y + GL VD + Sbjct: 338 ----DTQRVAYLRTAVDGVASCL-ADGIDVRGYIAWTAFDNFEWIFGYGPKFGLIAVDRS 392 Query: 485 SKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQ 518 + +ER PK SA + R+ + + Sbjct: 393 T--QERTPKESARWLGNFARQQAPAEAPQPAKLA 424 Score = 253 bits (646), Expect = 3e-67, Method: Composition-based stats. Identities = 90/467 (19%), Positives = 159/467 (34%), Gaps = 64/467 (13%) Query: 516 DVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQ 575 + FP DF WGV + + E ++ + VW L H + + Sbjct: 2 PMTNPFPQDFLWGVATAGHQVEG-------NNVNSDVWF-----LEHLPGTIFAEPSGDA 49 Query: 576 CTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGI 635 + ++ + ++A + T YRF+++WA + P + AL +Y+ V+ + G+ Sbjct: 50 VDHYHRYREDIALIAGLGFTSYRFSVEWARIEPE--EGHFSVAALDHYKRVLEACREHGL 107 Query: 636 SAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPN 695 + +VT + H P LL + GW T E F Y G LGDL+ + T+NEPN Sbjct: 108 TPVVTFH-----HFASPLWLLRSGGWEGERTPELFARYCGRVMAHLGDLIGVACTLNEPN 162 Query: 696 RLSDI--YNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPY 753 + + G + A A A RL + S + A+ Sbjct: 163 LPWLLESFGIGGEAPENRGKVPMWA-AAAQRLGVDASTVAPFQFCSTEAGFNVKLAAHKA 221 Query: 754 ADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRL 813 A +A + W + + +++ + E Sbjct: 222 ATEAIKAHR--PDLRVGWTLAN-----------SDIQSVPGGEEIAAQVRRDVNERFLEA 268 Query: 814 LKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLL 873 +G DF + + D + + P + + Sbjct: 269 SRGD-DFVGIQTYGRTV------------YGPDGHAPAPEGVAVNQMGEEIYPQALEATI 315 Query: 874 RWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKL 933 R R G + + +T +G+ A EDD R YL + V + L D + ++GY A+ Sbjct: 316 REAWRVAG-IPVMVTENGL---ATEDDTQRVAYLRTAVDGVA-SCLADGIDVRGYIAWTA 370 Query: 934 AEE-----KSKPRFGFFTSDFKA-----KSSIQFYNKVISSRGFPFE 970 + P+FG D K S ++ + P E Sbjct: 371 FDNFEWIFGYGPKFGLIAVDRSTQERTPKESARWLGNFARQQA-PAE 416 >3WDP-P nrPDB Length = 473 Score = 337 bits (864), Expect = 2e-92, Method: Composition-based stats. Identities = 105/498 (21%), Positives = 173/498 (34%), Gaps = 108/498 (21%) Query: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSD-------SYIF 133 FPKNF +G Q E + S W ++H +N++S S D + Sbjct: 4 FPKNFMFGYSWSGFQFEMGLP-GSEVESDWWVWVHDK-ENIASGLVSGDLPENGPAYWHL 61 Query: 134 LEKDLSALDFIGVSFYQFSISWPRLFPDGIVTV--------------------------- 166 ++D + +G+ + I W R+FP V Sbjct: 62 YKQDHDIAEKLGMDCIRGGIEWARIFPKPTFDVKVDVEKDEEGNIISVDVPESTIKELEK 121 Query: 167 -ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKY-----------GGWKNDTI 214 AN + L++Y + R I+ LYHW LPL + + GW ++ Sbjct: 122 IANMEALEHYRKIYSDWKERGKTFILNLYHWPLPLWIHDPIAVRKLGPDAAPAGWLDEKT 181 Query: 215 IDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGY--GTGMHAPGEKGNLAAVYTVGHN 272 + F +A + D V W T++ P +V GY PG + A N Sbjct: 182 VVEFVKFAAFVAYHLDDLVDMWSTMNEPNVVYNQGYINLASGFPPGF-LSFEAAEKAKFN 240 Query: 273 LIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFAN 332 LI+AH + + + + + + W +P E Sbjct: 241 LIQAHIGAYDAI----KEYSEKSVGVIYAFAWHDPLAEE--------------------- 275 Query: 333 PIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGP--NNFKPL-------- 382 D E +RKK + + I K + G + +G + PL Sbjct: 276 ----YKDEVEEIRKKDYEFVTILHSKGKLDWIGVNYYSRLVYGAKDGHLVPLPGYGFMSE 331 Query: 383 --------NTMAKMGQNVSL-NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAI 433 + G + L L ++ Y P I I ENG D Sbjct: 332 RGGFAKSGRPASDFGWEMYPEGLENLLKYLNNAYELPMI-ITENGMA-----DAADRYRP 385 Query: 434 YMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPK 493 + + + L V A++ + V GY WSL D +EW + +R GL YVDF +K++ +P Sbjct: 386 HYLVSHLKAVYNAMK-EGADVRGYLHWSLTDNYEWAQGFRMRFGLVYVDFETKKRYLRP- 443 Query: 494 SSAHYYKQIIRENGFSLK 511 SA +++I + + Sbjct: 444 -SALVFREIATQKEIPEE 460 Score = 317 bits (812), Expect = 2e-86, Method: Composition-based stats. Identities = 100/511 (19%), Positives = 183/511 (35%), Gaps = 113/511 (22%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVW-NATGNRLLHRVEGVRLKTRPAQCTD 578 +FP +F +G + S + E + + +VW + N V G + PA Sbjct: 3 KFPKNFMFGYSWSGFQFE-MGLPGSEVESDWWVWVHDKENIASGLVSGDLPENGPAY--- 58 Query: 579 FVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA------------------------ 614 + K+ ++ ++ + R ++WA + P Sbjct: 59 WHLYKQDHDIAEKLGMDCIRGGIEWARIFPKPTFDVKVDVEKDEEGNIISVDVPESTIKE 118 Query: 615 ----VNRQALRYYRCVVSEGLKLGISAMVTLY-YPTHAHLGLPEPLLHAD------GWLN 663 N +AL +YR + S+ + G + ++ LY +P + P + GWL+ Sbjct: 119 LEKIANMEALEHYRKIYSDWKERGKTFILNLYHWPLPLWIHDPIAVRKLGPDAAPAGWLD 178 Query: 664 PSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYN-------RSGNDTYGAAH--- 713 T F +A L DLV +W T+NEPN + + G ++ AA Sbjct: 179 EKTVVEFVKFAAFVAYHLDDLVDMWSTMNEPNVVYNQGYINLASGFPPGFLSFEAAEKAK 238 Query: 714 -NLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF 772 NL+ AH A YD S++ +V + W +P Sbjct: 239 FNLIQAHIGA---YDAIKEYSEK-SVGVIYAFAWHDPLAEEYKDEVEE------------ 282 Query: 773 AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVM 832 + DY E++ H KG +D+ +N+++ Sbjct: 283 ----IRKKDY-----EFVTILHS-------------------KGKLDWIGVNYYSRLVYG 314 Query: 833 HEQL---AGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITA 889 + Y + R +S + P G+ LL+++ Y ++ + IT Sbjct: 315 AKDGHLVPLPGYGFMSERGGFAKSGRPASDFGWEMYPEGLENLLKYLNNAY-ELPMIITE 373 Query: 890 SGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRFGF 944 +G+ D A DR R +YL +L+ V A + + ++GY + L + + RFG Sbjct: 374 NGMADAA---DRYRPHYLVSHLKAVYNA-MKEGADVRGYLHWSLTDNYEWAQGFRMRFGL 429 Query: 945 FTSDFKAKS-----SIQFYNKVISSRGFPFE 970 DF+ K S + ++ + + P E Sbjct: 430 VYVDFETKKRYLRPSALVFREIATQKEIPEE 460 >1GOW-A nrPDB Length = 489 Score = 307 bits (786), Expect = 2e-83, Method: Composition-based stats. Identities = 97/513 (18%), Positives = 175/513 (34%), Gaps = 103/513 (20%) Query: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDF 579 FP F +G +++ + E +P DP+ W + + G+ P + Sbjct: 3 SFPNSFRFGWSQAGFQSE--MGTPGSEDPNTD-WYKWVHDPENMAAGLVSGDLPENGPGY 59 Query: 580 V-NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSA------------------------ 614 N K + +M + R +W+ P Sbjct: 60 WGNYKTFHDNAQKMGLKIARLNSEWSRQFPNPLPRPQNFDESKQDVTEVEINENELKRLD 119 Query: 615 --VNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLH-----------ADGW 661 N+ AL +YR + + G+ + +Y H LP L GW Sbjct: 120 EYANKDALNHYREIFKDLKSRGLYFIQNMY-----HWPLPLWLHDPIRVRRGDFTGPSGW 174 Query: 662 LNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYG----------- 710 L+ T F ++ + DLV + T+NEPN + + + Sbjct: 175 LSTRTVYEFARFSAYTAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGYLSFELSRR 234 Query: 711 AAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIA 770 A +N++ AHA A YD S++ + ++ + P D A E Sbjct: 235 AMYNIIQAHARA---YDGIKSVSKKPVGIIYANSSF----QPLTDKDMEAVEMAENDNRW 287 Query: 771 WFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRF 830 WF + + +R I + + + R LKG +D+ +N++T Sbjct: 288 WFFDAI---------IRGEITRGNEKIV------------RDDLKGRLDWIGVNYYTRTV 326 Query: 831 VMHEQ---LAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYI 887 V + ++ Y + + +S P G+ +L Y + +Y+ Sbjct: 327 VKRTEKGYVSLGGYGHGCERNSVSLAGLPTSDFGWEFFPEGLYDVLTKYWNRY-HLYMYV 385 Query: 888 TASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEE-----KSKPRF 942 T +GI D A D R YYL ++ +V +A + ++GY + LA+ RF Sbjct: 386 TENGIADDA---DYQRPYYLVSHVYQVHRA-INSGADVRGYLHWSLADNYEWASGFSMRF 441 Query: 943 GFFTSDFKAKS-----SIQFYNKVISSRGFPFE 970 G D+ K S Y ++ ++ E Sbjct: 442 GLLKVDYNTKRLYWRPSALVYREIATNGAITDE 474 Score = 298 bits (763), Expect = 8e-81, Method: Composition-based stats. Identities = 91/507 (17%), Positives = 169/507 (33%), Gaps = 100/507 (19%) Query: 80 TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSD-------SYI 132 +FP +F +G Q E + W ++H +N+++ S D + Sbjct: 3 SFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHD-PENMAAGLVSGDLPENGPGYWG 61 Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTV-------------------------- 166 + +G+ + + W R FP+ + Sbjct: 62 NYKTFHDNAQKMGLKIARLNSEWSRQFPNPLPRPQNFDESKQDVTEVEINENELKRLDEY 121 Query: 167 ANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKY----------GGWKNDTIID 216 AN L +Y + L R + I +YHW LPL L + GW + + Sbjct: 122 ANKDALNHYREIFKDLKSRGLYFIQNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVY 181 Query: 217 IFNDYATYCFQMFGDRVKYWITIHNPY--LVAWHGYGTGMHAPGEKGNLAAVYTVGHNLI 274 F ++ Y F D V + T++ P + PG + +N+I Sbjct: 182 EFARFSAYTAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGY-LSFELSRRAMYNII 240 Query: 275 KAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPI 334 +AH++ + + K + I + +P ++ + + WF + I Sbjct: 241 QAHARAYDGI----KSVSKKPVGIIYANSSFQPLTDKDMEAVEMAENDNRW---WFFDAI 293 Query: 335 HGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLN----------- 383 G+ G K + +++G D+ ++ Sbjct: 294 I-RGEITRGNEKIVRD-----------DLKGRLDWIGVNYYTRTVVKRTEKGYVSLGGYG 341 Query: 384 -------------TMAKMGQN-VSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTED 429 + G L + L Y+ + + ENG D+ D Sbjct: 342 HGCERNSVSLAGLPTSDFGWEFFPEGLYDVLTKYWNRYHL-YMYVTENGIADDA-----D 395 Query: 430 TTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKE 489 Y + + + QV +AI V GY WSL D +EW +++R GL VD+N+K+ Sbjct: 396 YQRPYYLVSHVYQVHRAINS-GADVRGYLHWSLADNYEWASGFSMRFGLLKVDYNTKRLY 454 Query: 490 RKPKSSAHYYKQIIRENGFSLKESTPD 516 +P SA Y++I + + + Sbjct: 455 WRP--SALVYREIATNGAITDEIEHLN 479 >3NCO-A nrPDB Length = 320 Score = 46.1 bits (108), Expect = 8e-05, Method: Composition-based stats. Identities = 17/118 (14%), Positives = 36/118 (30%), Gaps = 14/118 (11%) Query: 130 SYIFLEKD--LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNI 187 S+ +D + G + I W + + L ++D + ++ Sbjct: 37 SWGVYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDRVKHVVDVALKNDL 96 Query: 188 EPIVTLYHWDLPLALQEKYGGWKND---TIIDIFNDYATYCFQMFGDRVKYWITIHNP 242 I+ +H++ +KYG + + F DY F + P Sbjct: 97 VVIINCHHFEELYQAPDKYGPVLVEIWKQVAQAFKDYPDKLFFEI---------FNEP 145 Score = 36.5 bits (83), Expect = 0.057, Method: Composition-based stats. Identities = 21/143 (14%), Positives = 44/143 (30%), Gaps = 25/143 (17%) Query: 560 LLHRVEGVRLKTRPAQCTDFVNIKKQ--LEMLARMKVTHYRFALDWASVLPTGNLSAVNR 617 + H + P + + + +++ R + W++ + +++ Sbjct: 20 IGHGINMGNALEAPVEG-SWGVYIEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDK 78 Query: 618 QALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADG------WLNPSTAEAFQ 671 L + VV LK + ++ + H G W A+AF+ Sbjct: 79 FFLDRVKHVVDVALKNDLVVIINCH-----HFEELYQAPDKYGPVLVEIW--KQVAQAFK 131 Query: 672 AYAGLCFQELGDLVKLWITINEP 694 Y F E+ NEP Sbjct: 132 DYPDKLFFEI---------FNEP 145 >6D8G-A nrPDB Length = 886 Score = 42.2 bits (98), Expect = 0.001, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 40/148 (27%), Gaps = 17/148 (11%) Query: 828 TRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAV-IPWGVRKLLRWVRRNYGDMDIY 886 + + GS ++ + + DI + G K L +N+ + Sbjct: 464 STRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWYGGDLTGFEKFLAQQHQNHPTHPMI 523 Query: 887 ITASGIDDQALEDD------RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKP 940 ++ G Y KYL E L D I G + + S Sbjct: 524 VSEYGAGSDKRLHSLHPRAFDFSIEYQQKYL-EHYLPVLEDTPYICGGTHWNFIDFSSAL 582 Query: 941 R---------FGFFTSDFKAKSSIQFYN 959 R G +D K +Y Sbjct: 583 RDESMPRINNKGLVYADRTPKDVYHYYQ 610 Score = 38.4 bits (88), Expect = 0.016, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 55/169 (32%), Gaps = 25/169 (14%) Query: 348 LFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVS--------LNLREA 399 L + L + E T F + N +G N+ + Sbjct: 451 LANRLERVLKEEDSTRISTMAFHGSNSY-NETGLSKITDIVGWNLYQGWYGGDLTGFEKF 509 Query: 400 LNWIKLEYNNPRILIAENGWFTDSRV----KTEDTTAIYMMKNFLSQVLQAIRLDEIRVF 455 L + ++++E G +D R+ +I + +L + + D + Sbjct: 510 LAQQHQNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYL-EHYLPVLEDTPYIC 568 Query: 456 GYTAWSLLDGFEWQDAYTIRR----GLFYVDFNSKQKERKPKSSAHYYK 500 G T W+ +D ++ R GL Y D R PK HYY+ Sbjct: 569 GGTHWNFIDFSSALRDESMPRINNKGLVYAD-------RTPKDVYHYYQ 610 >4EKJ-A nrPDB Length = 500 Score = 39.9 bits (92), Expect = 0.006, Method: Composition-based stats. Identities = 28/125 (22%), Positives = 46/125 (36%), Gaps = 32/125 (25%) Query: 142 DFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYS-----TLLDALVLRNIEPIV----- 191 D +G + +F +F D + TV G Y L DAL+ + I+P + Sbjct: 52 DELGFRYIRFHA----IFHDVLGTVKVQDGKIVYDWTKIDQLYDALLAKGIKPFIELGFT 107 Query: 192 ---------TLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFG-DRVKYWI--TI 239 T+++W K G W +ID F + +G + V+ W Sbjct: 108 PEAMKTSDQTIFYWKG-NTSHPKLGPW--RDLIDAFVHHLR---ARYGVEEVRTWFFEVW 161 Query: 240 HNPYL 244 + P L Sbjct: 162 NEPNL 166 Score = 34.5 bits (78), Expect = 0.27, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 44/174 (25%), Gaps = 32/174 (18%) Query: 591 RMKVTHYRFALDWASVLPTGNLSAVNRQALRYYR-----CVVSEGLKLGISAMVTL-YYP 644 + + RF + + + Y + L GI + L + P Sbjct: 53 ELGFRYIRFHA----IFHDVLGTVKVQDGKIVYDWTKIDQLYDALLAKGIKPFIELGFTP 108 Query: 645 --------THAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG-DLVKLWI--TINE 693 T + W +AF + G + V+ W NE Sbjct: 109 EAMKTSDQTIFYWKGNTSHPKLGPW--RDLIDAFVHHLR---ARYGVEEVRTWFFEVWNE 163 Query: 694 PNRLSDIYNRSGNDTYGAAHNLLV-AHALAWRLYDRQFRPSQRGAVSLSLHADW 746 PN AA+ L A A + D R + ++ Sbjct: 164 PNLDGFW-----EKADQAAYFELYDVTARAIKAIDPSLRVGGPATAGAAWVPEF 212 >4JKL-A nrPDB Length = 602 Score = 38.8 bits (89), Expect = 0.015, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 57/196 (29%), Gaps = 40/196 (20%) Query: 778 KTGDYPAAMREYIASKHRRGLSSSAL-PRLTEAERRLLKGTVDFCALNHFTTRFVMHEQL 836 DY + + + + + + +R + VD LN + +V H L Sbjct: 418 GAHDYFEPLVKLYKDLDPQKRPVTLVNILMATPDRDQVMDLVDVVCLNRYYGWYVDHGDL 477 Query: 837 AGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQA 896 + G+RK L + + D I IT G D Sbjct: 478 TNAE--------------------------VGIRKELLEWQDKFPDKPIIITEYGADTLP 511 Query: 897 LEDDRLRKYYLGKY---LQEVLKAYLIDKV-RIKGYYAFKLAE---EKSKPRF-----GF 944 Y ++ E+ D + + G + A+ R G Sbjct: 512 GLHSTWNIPYTEEFQCDFYEMSHRVF-DGIPNLVGEQVWNFADFETNLMILRVQGNHKGL 570 Query: 945 FTSDFKAKSSIQFYNK 960 F+ + + K ++ + K Sbjct: 571 FSRNRQPKQVVKEFKK 586 Score = 36.1 bits (82), Expect = 0.076, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 57/179 (31%), Gaps = 29/179 (16%) Query: 339 DYPEGMRKKLFSVLPI----------FSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKM 388 DY E + K + P + ++ ++ D + + + Sbjct: 421 DYFEPLVKLYKDLDPQKRPVTLVNILMATPDRDQVMDLVDVVCLNRYYGWYVDHGDLT-- 478 Query: 389 GQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNF---LSQVLQ 445 N + +R+ L + ++ + I+I E G D+ T I + F ++ Sbjct: 479 --NAEVGIRKELLEWQDKFPDKPIIITEYGA--DTLPGLHSTWNIPYTEEFQCDFYEMSH 534 Query: 446 AIRLDEIRVFGYTAWSLLD---GFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQ 501 + + G W+ D +GLF + R+PK +K+ Sbjct: 535 RVFDGIPNLVGEQVWNFADFETNLMILRVQGNHKGLF-------SRNRQPKQVVKEFKK 586 Score = 29.9 bits (66), Expect = 6.1, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 38/131 (29%), Gaps = 30/131 (22%) Query: 585 QLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCV----VSEGLKLGISAMVT 640 L +L M +R + + + +R + + E V Sbjct: 316 DLNLLKDMGANSFRTS-----------HYPYSEEMMRLADRMGVLVIDEV------PAVG 358 Query: 641 LYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDL--VKLWITINEPNRLS 698 L+ +A L L W T A + + + V +W+ NEP Sbjct: 359 LFQNFNASLDL--SPKDNGTWNLMQTKAAHEQAIQELVKRDKNHPSVVMWVVANEP---- 412 Query: 699 DIYNRSGNDTY 709 + +G Y Sbjct: 413 -ASHEAGAHDY 422 >4IM4-A nrPDB Length = 336 Score = 38.8 bits (89), Expect = 0.015, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 45/121 (37%), Gaps = 8/121 (6%) Query: 586 LEMLARMKVTHYRFALDW-ASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYP 644 +E + M R + W + P + ++ L VV+ L G+ A++ L++ Sbjct: 42 IEKVREMGFNAVRVPVTWDTHIGPAPDY-KIDEAWLNRVEEVVNYVLDCGMYAIINLHHD 100 Query: 645 THAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRS 704 +P + ++ A F++ D + L+ T+NEP + Sbjct: 101 NT--WIIPTYANEQR--SKEKLVKVWEQIATR-FKDYDDHL-LFETMNEPREVGSPMEWM 154 Query: 705 G 705 G Sbjct: 155 G 155 Score = 38.0 bits (87), Expect = 0.022, Method: Composition-based stats. Identities = 17/112 (15%), Positives = 48/112 (42%), Gaps = 10/112 (8%) Query: 138 LSALDFIGVSFYQFSISW-PRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYH- 195 + + +G + + ++W + P + + L +++ ++ + I+ L+H Sbjct: 42 IEKVREMGFNAVRVPVTWDTHIGPAPDYKI-DEAWLNRVEEVVNYVLDCGMYAIINLHHD 100 Query: 196 --WDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLV 245 W +P E+ + ++ ++ AT F+ + D + + T++ P V Sbjct: 101 NTWIIPTYANEQRS---KEKLVKVWEQIATR-FKDYDDHL-LFETMNEPREV 147 >5NQA-A nrPDB Length = 578 Score = 38.4 bits (88), Expect = 0.019, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 37/119 (31%), Gaps = 9/119 (7%) Query: 693 EPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANP 752 E + S + + A N L A A ++ +++ + + Sbjct: 353 EIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEH-------FYNRNPPARKEA 405 Query: 753 YADSHWRA--AERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEA 809 Y D R ER W+ + +F P + + RG+SS L + Sbjct: 406 YGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPD 464 >3AZS-A nrPDB Length = 317 Score = 38.0 bits (87), Expect = 0.021, Method: Composition-based stats. Identities = 19/154 (12%), Positives = 42/154 (27%), Gaps = 42/154 (27%) Query: 104 GKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWP------- 156 G+G +I + D + + G S + I W Sbjct: 13 GRGINIGNAL--EAPNEGDWGVVIKD------EFFDIIKEAGFSHVRIPIRWSTHAYAFP 64 Query: 157 --RLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW-----DLPLALQEKYGGW 209 ++ V +++ + R + ++ ++H+ D + W Sbjct: 65 PYKIMDRFFKRV---------DEVINGALKRGLAVVINIHHYEELMNDPEEHKERFLALW 115 Query: 210 KNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPY 243 I D + DY F ++ P+ Sbjct: 116 --KQIADRYKDYPETLFFEI---------LNEPH 138 >5Z19-A nrPDB Length = 627 Score = 37.2 bits (85), Expect = 0.033, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 51/142 (35%), Gaps = 20/142 (14%) Query: 367 ADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVK 426 DF + + + + + R+ ++ K + N + E + TD+ Sbjct: 490 CDFICLNRYYGWYISGGPEIEEAEEL---FRDEMDRWKAKELNVPFVFTE--FGTDTMAG 544 Query: 427 TEDTTAI----YMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVD 482 +I K +L + E V G AW+ D + G+ VD Sbjct: 545 LHKLPSIMWSEEYQKEYLEMNFRVFDSYEF-VQGELAWNFAD-------FQTTEGIMRVD 596 Query: 483 FNSK---QKERKPKSSAHYYKQ 501 N K ++R+PK++A +K Sbjct: 597 GNHKGVFTRDRQPKAAAVVFKD 618 >1CEO-A nrPDB Length = 343 Score = 36.8 bits (84), Expect = 0.051, Method: Composition-based stats. Identities = 12/99 (12%), Positives = 32/99 (32%), Gaps = 3/99 (3%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 +K +E +A H R D+ + N+ L Y + K + ++ ++ Sbjct: 31 EKDIETIAEAGFDHVRLPFDYPIIESDDNVGEYKEDGLSYIDRCLEWCKKYNLGLVLDMH 90 Query: 643 YPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQEL 681 + + + + +P+ + F + Sbjct: 91 HAPGYRF---QDFKTSTLFEDPNQQKRFVDIWRFLAKRY 126 Score = 34.9 bits (79), Expect = 0.21, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 24/61 (39%) Query: 135 EKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLY 194 EKD+ + G + +P + D V GL Y L+ N+ ++ ++ Sbjct: 31 EKDIETIAEAGFDHVRLPFDYPIIESDDNVGEYKEDGLSYIDRCLEWCKKYNLGLVLDMH 90 Query: 195 H 195 H Sbjct: 91 H 91 >4UCF-A nrPDB Length = 689 Score = 36.5 bits (83), Expect = 0.058, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 44/142 (30%), Gaps = 47/142 (33%) Query: 134 LEKDLSALDFIGVSFYQFSI-SWPRLFPDGIVTVANAKG---LQYYSTLLDALVLRNI-- 187 + D+ + GV+ I SW ++ P +G + +D L I Sbjct: 36 WDDDIRLMKKAGVNLVSVGIFSWAKIEP--------EEGKYDFDWLDRAIDKLGKAGIAV 87 Query: 188 -------EP--IVTLYHWDLPLALQEKYGG---WKN-----DTIIDIFNDYA----TYCF 226 P +T H P L + G W +F +YA Sbjct: 88 DLASATASPPMWLTQAH---PEVLWKDERGDTVWPGAREHWRPTSPVFREYALNLCRRMA 144 Query: 227 QMFGDRVKYWITIHNPYLVAWH 248 + + NPY+VAWH Sbjct: 145 EHYKG---------NPYVVAWH 157 Score = 35.7 bits (81), Expect = 0.11, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 36/134 (26%), Gaps = 24/134 (17%) Query: 582 IKKQLEMLARMKVTHYRFAL-DWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS---A 637 + ++ + V + WA + P + + + K GI+ A Sbjct: 36 WDDDIRLMKKAGVNLVSVGIFSWAKIEPEEGKYDF-----DWLDRAIDKLGKAGIAVDLA 90 Query: 638 MVTLYYPTHAHLGLPEPL-LHADG---WLN-----PSTAEAFQAYA----GLCFQELGDL 684 T P PE L G W T+ F+ YA + Sbjct: 91 SATASPPMWLTQAHPEVLWKDERGDTVWPGAREHWRPTSPVFREYALNLCRRMAEHYKGN 150 Query: 685 --VKLWITINEPNR 696 V W NE Sbjct: 151 PYVVAWHVSNEYGC 164 >5H4R-A nrPDB Length = 396 Score = 36.1 bits (82), Expect = 0.089, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 48/128 (37%), Gaps = 17/128 (13%) Query: 583 KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLY 642 K+ ++ + + R + W + TG+ ++++ L + VV +K + ++ ++ Sbjct: 83 KQMIDTVKKAGFNTIRIPVSWHN-HVTGSNFTISKRWLDRVQQVVDYAMKNKMYVIINIH 141 Query: 643 YPTHAHLGLP--EPLLH-----ADGWLNPSTAEAFQAYAG-LCFQEL------GDLVKLW 688 + P + L W A F+ Y L F+ + G + W Sbjct: 142 HDIMPGYYYPNSQHLQTSIKYVKSIWT--QVATRFKNYNDHLIFEAVNQPRLTGSRFEWW 199 Query: 689 ITINEPNR 696 + +N P Sbjct: 200 LDMNNPEC 207 Score = 35.3 bits (80), Expect = 0.16, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 43/125 (34%), Gaps = 21/125 (16%) Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197 + + G + + +SW G + + L ++D + + I+ ++H Sbjct: 86 IDTVKKAGFNTIRIPVSWHNHV-TGSNFTISKRWLDRVQQVVDYAMKNKMYVIINIHHDI 144 Query: 198 LP-------LALQEKY----GGWKNDTIIDIFNDYAT-YCFQMF------GDRVKYWITI 239 +P LQ W + F +Y F+ G R ++W+ + Sbjct: 145 MPGYYYPNSQHLQTSIKYVKSIWT--QVATRFKNYNDHLIFEAVNQPRLTGSRFEWWLDM 202 Query: 240 HNPYL 244 +NP Sbjct: 203 NNPEC 207 >3NJ3-A nrPDB Length = 341 Score = 35.7 bits (81), Expect = 0.11, Method: Composition-based stats. Identities = 44/318 (13%), Positives = 86/318 (27%), Gaps = 88/318 (27%) Query: 194 YHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTG 253 +H LP + + W + ++++ D+ F RVK W ++ V+ G Sbjct: 105 WHNQLPGWITGRE--WTKEELLNVLEDHIKTVVSHFKGRVKIWDVVNE--AVSDSG---- 156 Query: 254 MHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENT 313 Y G I W + + Sbjct: 157 -----------------------------TYRESVWYKTIGPEYIEKAFRWTKEADPD-- 185 Query: 314 MDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFS 373 +++ + I+ ++ M K+L + + D+ + Sbjct: 186 --------AILIYNDYSIEEINAKSNFVYNMIKELKEKGV---PVDGIGFQMHIDYRGLN 234 Query: 374 FGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAI 433 + + R L +I I E D R+ + Sbjct: 235 YD-------------------SFRRNLERFAKL--GLQIYITE----MDVRIPLSGSE-D 268 Query: 434 YMMKNFLSQVLQA--IRLDEIRVFGYTAWSLLDGFEWQDAYTIRRG---LFYVDFNSKQK 488 Y +K + I LD V W D + W + G LF ++N Sbjct: 269 YYLKKQAEICAKIFDICLDNPAVKAIQFWGFTDKYSWVPGFFKGYGKALLFDENYN---- 324 Query: 489 ERKPKSSAHYYKQIIREN 506 PK + K+++ + Sbjct: 325 ---PKPCYYAIKEVLEKK 339 Score = 31.1 bits (69), Expect = 2.8, Method: Composition-based stats. Identities = 9/51 (17%), Positives = 16/51 (31%), Gaps = 1/51 (1%) Query: 643 YPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINE 693 + H LP + + W + + VK+W +NE Sbjct: 101 HTLVWHNQLPGWITGRE-WTKEELLNVLEDHIKTVVSHFKGRVKIWDVVNE 150 >3AYR-A nrPDB Length = 376 Score = 35.3 bits (80), Expect = 0.13, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 60/172 (34%), Gaps = 31/172 (18%) Query: 569 LKTRPAQCTDFVNIKKQ-----------------LEMLARMKVTHYRFALDWASVLPTGN 611 T AQC +++N +K ++L + +R W+ Sbjct: 34 GNTMDAQCIEYLNYEKDQTASETCWGNPKTTEDMFKVLIDNQFNVFRIPTTWSGHFGEAP 93 Query: 612 LSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAH-----LGLPEPLLHADGWLNPST 666 ++ + L+ VV K G ++ L++ T H L + +L W Sbjct: 94 DYKIDEKWLKRVHEVVDYPYKNGAFVILNLHHETWNHAFSETLDTAKEILEKI-W--SQI 150 Query: 667 AEAFQAYAG-LCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLV 717 AE F+ Y L F+ L + K N+ ++ G D A + + + Sbjct: 151 AEEFKDYDEHLIFEGLNEPRK-----NDTPVEWTGGDQEGWDAVNAMNAVFL 197 >5D8Z-A nrPDB Length = 347 Score = 34.9 bits (79), Expect = 0.17, Method: Composition-based stats. Identities = 20/147 (13%), Positives = 43/147 (29%), Gaps = 14/147 (9%) Query: 554 NATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLS 613 + T N + + +R + W + Sbjct: 39 DGTCNASGAWPPLTQYYGADGAGQMKHFVDDD-------GFNVFRLPVGWQFITDGVAGG 91 Query: 614 AVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAY 673 ++ Y +V L G S +V ++ + ++ G N A + + Sbjct: 92 DIDEDNWAEYDALVQACLDAGASCIVDVHNYARFN----GEIIGQGGPTNQDFAALWSSI 147 Query: 674 AGLCFQELGDLVKLWITINEPNRLSDI 700 A D + ++ +NEP+ + DI Sbjct: 148 AAKYADN--DKI-IFGVMNEPHDVPDI 171 Score = 29.5 bits (65), Expect = 8.2, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 53/164 (32%), Gaps = 24/164 (14%) Query: 84 NFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDF 143 F +G G+ +G+ G P L +G+ F++ D Sbjct: 31 GFDFGCGS-----DGTCNASGAWP---------PLTQYYGADGAGQMKHFVDDD------ 70 Query: 144 IGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQ 203 G + ++ + W + + Y L+ A + IV ++++ Sbjct: 71 -GFNVFRLPVGWQFITDGVAGGDIDEDNWAEYDALVQACLDAGASCIVDVHNYARFNGEI 129 Query: 204 EKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAW 247 GG N +++ A D++ + ++ P+ V Sbjct: 130 IGQGGPTNQDFAALWSSIAAKYADN--DKI-IFGVMNEPHDVPD 170 >6BJW-A nrPDB Length = 635 Score = 34.9 bits (79), Expect = 0.18, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 40/123 (32%), Gaps = 21/123 (17%) Query: 853 ITRLSSPTRLAVIPWGVRKLLRWVRRNYGDM--DIYITASGIDDQALEDDRLRKYYLGKY 910 L V G+RK L ++G + + T G D + D Y +Y Sbjct: 506 YGWYFGGPDLEVSEIGLRKEL----SDWGKLGKPVMFTEYGADTVSGLHDTTSVMYTEEY 561 Query: 911 ---LQEVLKAYLIDKVRIKGYYAFKLAE----------EKSKPRFGFFTSDFKAKSSIQF 957 E+ + + G A+ A+ + +K G FT D K K + Sbjct: 562 QVEYYEMNNKVFDEFDFVVGEQAWNFADFATSQSLLRVQGNKK--GLFTRDRKPKMVAHY 619 Query: 958 YNK 960 + Sbjct: 620 FRN 622 >4UOQ-A nrPDB Length = 695 Score = 34.9 bits (79), Expect = 0.20, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 49/160 (30%), Gaps = 30/160 (18%) Query: 583 KKQLEMLARMKVTHYRFAL-DWASVL-PTGNLSAVNRQALRYYRCVVSEGLKLGI---SA 637 + + ++ + V A+ WA++ GN + V+ + K GI A Sbjct: 40 DEDIRLMKQAGVNIVSLAIFSWANIETSDGNFE------FDWLDRVIDKLYKAGIAVDLA 93 Query: 638 MVTLYYPTHAHLGLPEPL-LHADG---WLN-----PSTAEAFQAYAGLCFQELGDLVKLW 688 T P PE L G W T+ F+ YA +E+ + K Sbjct: 94 SATASPPMWLTSAHPEVLRRDEQGHVIWPGARQHWRPTSPTFRTYALRLCREMAEHYKD- 152 Query: 689 ITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDR 728 N + N G HN A + + Sbjct: 153 ---NPAIVSWHVGNEYG------CHNYFDYSDDAVQAFRE 183 Score = 34.9 bits (79), Expect = 0.21, Method: Composition-based stats. Identities = 23/142 (16%), Positives = 42/142 (29%), Gaps = 34/142 (23%) Query: 135 EKDLSALDFIGVSFYQFSI-SWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNI------ 187 ++D+ + GV+ +I SW + + N + + ++D L I Sbjct: 40 DEDIRLMKQAGVNIVSLAIFSWANI----ETSDGNFE-FDWLDRVIDKLYKAGIAVDLAS 94 Query: 188 ---EP--IVTLYHWDLPLALQEKYGG---WKN-----DTIIDIFNDYA----TYCFQMFG 230 P +T H P L+ G W F YA + + Sbjct: 95 ATASPPMWLTSAH---PEVLRRDEQGHVIWPGARQHWRPTSPTFRTYALRLCREMAEHYK 151 Query: 231 DR--VKYWITIHNPYLVAWHGY 250 D + W + + Y Sbjct: 152 DNPAIVSWHVGNEYGCHNYFDY 173 >5BX9-A nrPDB Length = 416 Score = 34.9 bits (79), Expect = 0.21, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 51/158 (32%), Gaps = 14/158 (8%) Query: 581 NIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVT 640 KQ++ L + + R L W + +A ++ L +V + + ++ Sbjct: 34 RYNKQIDRLQDLGLEWVRLDLHWDRL-----ETAEDQYQLASLDQLVKDLEARQLKSVFY 88 Query: 641 LYYPTHAHLGLPE--PLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLS 698 L P P P E F + Q V W NEPN + Sbjct: 89 LVGSARFITTAPFYSPFQDQYP---PRDPEVFARRMAMLSQRYP-SVAAWQVWNEPNLIG 144 Query: 699 DIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRG 736 ++ + Y LL A +A R+ D + G Sbjct: 145 FWRPKADPEGYA---KLLQASTIALRMVDPEKPVVSAG 179 >5J7Z-A nrPDB Length = 500 Score = 34.5 bits (78), Expect = 0.24, Method: Composition-based stats. Identities = 33/262 (12%), Positives = 68/262 (25%), Gaps = 53/262 (20%) Query: 584 KQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYY 643 + +++L R R + +++P ++ L VV G ++ Sbjct: 83 QDIDILVRHGFNTVRLGTSFDALMPQ--RGQIDEAYLDRLTGVVDALTARG------MHV 134 Query: 644 PTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYN- 702 H +G+ + + W EPN +Y Sbjct: 135 LLDNHQDGLSKAWGGNGFPE---------------WAIESRPREW----EPNPGFPLYYL 175 Query: 703 -----RSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL-SLHADWAEP------- 749 ++ +G H L A + + G + + L+ W Sbjct: 176 MPSLNAGWDEVWGNTHGALDHLGTALGALAERV-EGKPGVMGIELLNEPWPGSRFLSCFP 234 Query: 750 -ANPYADSHWRAAE-------RFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSS 801 P D ++AA R I + EP M + + ++ Sbjct: 235 NGCPDFDRTYQAAMQKLTDAVRAQNPTIPVYWEPNVTW---NQMMPSNLFAPPVTPALTT 291 Query: 802 ALPRLTEAERRLLKGTVDFCAL 823 A + + + L Sbjct: 292 ADVVFAPHDYCIPSQLAIYLGL 313 >6ECA-A nrPDB Length = 627 Score = 33.8 bits (76), Expect = 0.45, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 41/104 (39%), Gaps = 15/104 (14%) Query: 868 GVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLK--AYLIDKVR- 924 G+R + ++ + T G D +A + +Y EVLK + + D Sbjct: 512 GLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQVEVLKMFSRVFDDYDF 571 Query: 925 IKGYYAFKLAE----------EKSKPRFGFFTSDFKAKSSIQFY 958 IKG + LA+ +K G FT D + K++ FY Sbjct: 572 IKGEQVWNLADFQTVEGNMRVNGNKK--GIFTRDRQPKAAAFFY 613 >6FCG-A nrPDB Length = 430 Score = 33.4 bits (75), Expect = 0.49, Method: Composition-based stats. Identities = 30/197 (15%), Positives = 68/197 (34%), Gaps = 25/197 (12%) Query: 773 AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVM 832 + L K GD + +I S P+ + L VD+ +++ + Sbjct: 192 LQALKKKGDLSKDL--WITSSDNFASWGGGDPQYHVEDLTKLIEAVDYLSVHTYPMHDTH 249 Query: 833 HEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITA--- 889 + + + + ++ L+ I + + + + +++ + I+I Sbjct: 250 YNPIFWGVFGDETELSSLKRIDIAMNRAKTYAVSQS-DSVASYIKSLGINKPIHIGETGW 308 Query: 890 ----SGI--DDQALEDDRLRKYYLGKYLQE-VLKAYLIDKVRIKGYY-----AFKLAEE- 936 +G + D ++ +++E +A + Y+ +K A Sbjct: 309 ASFSNGYYGAKGSKATDEYKEAIFYNHIREWTNEANMS-----CFYFEAFDEPWKDAHNS 363 Query: 937 -KSKPRFGFFTSDFKAK 952 S+ FG FT D KAK Sbjct: 364 GGSENHFGLFTVDGKAK 380 >4YMX-A nrPDB Length = 260 Score = 33.0 bits (74), Expect = 0.65, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 39/98 (39%), Gaps = 9/98 (9%) Query: 815 KGTVDFCALNHFTTR--FVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKL 872 K +VDF L ++ +R V+ S++D + I S + P K Sbjct: 114 KKSVDFSDL-YYDSRQVVVVKNDSPISKFDDLKVKTIAVQIGTTSEEAAKKI-PNVKLKQ 171 Query: 873 LRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKY 910 L V + D+ +G D + +D + K YL +Y Sbjct: 172 LNRVSDEFMDL-----QNGRCDAIVVEDTVAKAYLKEY 204 >6ETZ-A nrPDB Length = 989 Score = 33.0 bits (74), Expect = 0.67, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 68/228 (29%), Gaps = 48/228 (21%) Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW- 196 L + ++ + S +P +A A L +Y L L E W Sbjct: 332 LRLMKQHNINAIRTSH-----YPPHPQFLALADQLGFYVVLECDLETHGFESAG----WA 382 Query: 197 ----DLPLA---LQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHG 249 D P L ++ ++ ++A+ G + G Sbjct: 383 QNPSDDPQWEDALVDRM-----RRTVERDKNHASVVMWSLG---------NE------AG 422 Query: 250 YGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNR 309 G + A H S+ Y+ + + L IEP Sbjct: 423 TGRNLAAMSRWTKDRDPSRPIHYEGDWSSEHVDVYSRMYASQAET----ALIGQGIEPAL 478 Query: 310 SENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKK--LFSVLPIF 355 ++ +D +++M VL + +H G+ P GM + LF P Sbjct: 479 NDAALD--ARRRAMPFVLCEY---VHAMGNGPGGMSEYQALFEKYPRL 521 >6CXS-A nrPDB Length = 602 Score = 32.6 bits (73), Expect = 1.0, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 32/105 (30%), Gaps = 15/105 (14%) Query: 869 VRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLI--DKV-RI 925 + L+ I T G D A D + + +Y E KA DK Sbjct: 488 LEDELKGWEERCPKTPIMFTEYGADTVAGLHDTVPVMFTEEYQVEYYKANHEVMDKCKNF 547 Query: 926 KGYYAFKLAE----------EKSKPRFGFFTSDFKAKSSIQFYNK 960 G + A+ + +K G FT + K K + Sbjct: 548 VGEQVWNFADFATSQGIIRVQGNKK--GIFTRERKPKMIAHSLRE 590 >3CMG-A nrPDB Length = 667 Score = 31.8 bits (71), Expect = 1.7, Method: Composition-based stats. Identities = 10/67 (14%), Positives = 20/67 (29%), Gaps = 29/67 (43%) Query: 133 FLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYST---LLDALVLRNI-- 187 E+D++ + +GV+ + L +Y + D + I Sbjct: 305 HHEEDVALMREMGVNAIR---------------------LAHYPQATYMYDLMDKHGIVT 343 Query: 188 ---EPIV 191 P V Sbjct: 344 WAEIPFV 350 Score = 30.7 bits (68), Expect = 3.2, Method: Composition-based stats. Identities = 3/18 (16%), Positives = 9/18 (50%) Query: 581 NIKKQLEMLARMKVTHYR 598 + ++ + ++ M V R Sbjct: 305 HHEEDVALMREMGVNAIR 322 >3ZMS-C nrPDB Length = 509 Score = 31.8 bits (71), Expect = 1.7, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 17/44 (38%), Gaps = 5/44 (11%) Query: 887 ITASGIDDQALE-----DDRLRKYYLGKYLQEVLKAYLIDKVRI 925 ++ SG +D E R+ YL K+L +A + Sbjct: 356 VSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPL 399 Score = 31.8 bits (71), Expect = 1.8, Method: Composition-based stats. Identities = 3/24 (12%), Positives = 8/24 (33%) Query: 431 TAIYMMKNFLSQVLQAIRLDEIRV 454 ++ L QA++ + Sbjct: 376 RRQAYLRKHLLAHHQALQAKGAPL 399 >4B3J-A nrPDB Length = 736 Score = 31.4 bits (70), Expect = 2.0, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 35/115 (30%), Gaps = 21/115 (18%) Query: 177 TLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYW 236 + D + PIV G+ +I F + A M G+ V Sbjct: 504 RVFDYTLAIGKTPIV-----------VNDSRGFFTSRVIGTFVNEA---LAMLGEGV--- 546 Query: 237 ITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPH 291 P + G G AP + + + H + A K + ++PH Sbjct: 547 ----EPASIEQAGSQAGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPH 597 >5T99-A nrPDB Length = 822 Score = 31.1 bits (69), Expect = 2.6, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 17/38 (44%), Gaps = 5/38 (13%) Query: 115 HTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFS 152 H + ++ N +D E+ L + +GV+ + S Sbjct: 316 HDNGPMGAAVNVRAD-----ERKLQIMKEMGVNAIRTS 348 >5XZO-A nrPDB Length = 335 Score = 31.1 bits (69), Expect = 2.6, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 19/45 (42%) Query: 197 DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 +LP + W N+T+ + ++ FGD+ W ++ Sbjct: 91 ELPTWVTNPTTNWTNETLSKVLQNHVYTLVSHFGDQCYSWDVVNE 135 >3ZPX-A nrPDB Length = 458 Score = 31.1 bits (69), Expect = 2.7, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 37/98 (37%), Gaps = 14/98 (14%) Query: 245 VAWHGYGTGMHAPGEKGNLAAVYTVGHNLI-KAHSKVWHNYNTHFRPHQKGWL------- 296 + ++GY G HA G NLA Y HN+I A+ + + F KG Sbjct: 168 IGFYGYSGGAHATGWAANLAGSYAPEHNIIGAAYGGLPASARDTFNFLNKGAFAGFAIAG 227 Query: 297 --SITLGS----HWIEPNRSENTMDIFKCQQSMVSVLG 328 + L +I+ + +FK +S +G Sbjct: 228 VSGLALAYPDVETYIQSRLNAKGEKVFKQVRSRGFCIG 265 >5E0C-A nrPDB Length = 537 Score = 31.1 bits (69), Expect = 2.8, Method: Composition-based stats. Identities = 11/86 (12%), Positives = 27/86 (31%), Gaps = 6/86 (6%) Query: 569 LKTRPAQCTDFVNI------KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRY 622 T A D ++ ++ +A R + W + + +N Sbjct: 24 GNTFDAVGDDETAWGNPRVTRELIKTIADEGYKSIRIPVTWENQMGNAPDYTINEDFFSR 83 Query: 623 YRCVVSEGLKLGISAMVTLYYPTHAH 648 V+ L+ + M+ L++ + Sbjct: 84 VEQVIDWALEEDLYVMLNLHHDSWLW 109 >6GL0-A nrPDB Length = 331 Score = 30.7 bits (68), Expect = 3.1, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 41/115 (35%), Gaps = 22/115 (19%) Query: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYH-- 195 + + +G + ++W +G + A L + + + + I+ ++H Sbjct: 45 IDEIAKMGFKTLRLPVTWKFHIGEGPDYLIEANWLDKVEAIANFALENEMYVIINIHHDE 104 Query: 196 -WDLPLA-----LQEKYGG-WKNDTIIDIFNDYATY-CFQMFGDRVKYWITIHNP 242 W LP ++++ W I + F Y Y F+ T++ P Sbjct: 105 TWILPTYEKADEVKDELSKVWT--QIANRFKTYGDYLIFE----------TLNEP 147 Score = 29.5 bits (65), Expect = 7.0, Method: Composition-based stats. Identities = 17/116 (14%), Positives = 38/116 (32%), Gaps = 16/116 (13%) Query: 586 LEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPT 645 ++ +A+M R + W + G + L + + L+ + ++ +++ Sbjct: 45 IDEIAKMGFKTLRLPVTWKFHIGEGPDYLIEANWLDKVEAIANFALENEMYVIINIHHDE 104 Query: 646 HAHLGLP-----EPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNR 696 LP + + + A F+ Y E T+NEP Sbjct: 105 T--WILPTYEKADEVKDELSKVWTQIANRFKTYGDYLIFE---------TLNEPRH 149 >5KH2-A nrPDB Length = 272 Score = 30.7 bits (68), Expect = 3.6, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 22/54 (40%), Gaps = 6/54 (11%) Query: 139 SALDFIGVSF---YQFSIS-WPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIE 188 A + +GV Y FS W R PD V +++Y + L N++ Sbjct: 77 KAANKLGVKVITVYAFSTENWTR--PDQEVKFIMNLPVEFYDNYVPELHANNVK 128 >5Z1B-A nrPDB Length = 692 Score = 30.7 bits (68), Expect = 3.8, Method: Composition-based stats. Identities = 15/107 (14%), Positives = 32/107 (29%), Gaps = 33/107 (30%) Query: 884 DIYITASGID---------DQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYA---- 930 + T G D + ++ R YY A + ++ + ++ Sbjct: 593 PVMFTEYGADTIEGIHGTHGEMFSEEFQRDYY----------ARINAEIDKRPWFIGEQL 642 Query: 931 FKLAE--------EKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPF 969 + A+ R G T D + K + + + + G P Sbjct: 643 WNFADFATFQGIIRVEGNRKGILTRDRQPKMAAHWLRERWA--GIPD 687 >1OY5-A nrPDB Length = 257 Score = 30.3 bits (67), Expect = 4.2, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 14/38 (36%) Query: 852 DITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITA 889 D + + P + + +V NYG + IT Sbjct: 53 DDVPYGGLPGMVLKPEPIYEAYDYVVENYGKPFVLITE 90 >3L5H-A nrPDB Length = 589 Score = 30.3 bits (67), Expect = 4.2, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 17/45 (37%), Gaps = 10/45 (22%) Query: 916 KAYLIDKVRIKGYYAFK-LAEEKSKPRFGFFTSDFKAKSSIQFYN 959 + D KGY + +EE S G D +K+ +Y Sbjct: 277 RCMKEDG---KGY--WSDWSEEAS----GITYEDRPSKAPSFWYK 312 >1W3H-A nrPDB Length = 359 Score = 30.3 bits (67), Expect = 5.0, Method: Composition-based stats. Identities = 10/53 (18%), Positives = 19/53 (35%), Gaps = 8/53 (15%) Query: 192 TL-YH--WDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHN 241 TL +H + LP + ++ F + F +VK W ++ Sbjct: 92 TLVWHPSYQLPNWASDSNANFR-----QDFARHIDTVAAHFAGQVKSWDVVNE 139 >4IEH-A nrPDB Length = 169 Score = 30.3 bits (67), Expect = 5.0, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 38/132 (28%), Gaps = 27/132 (20%) Query: 550 LYVWNATGNRLLHRVEGVRLK----TRPAQCTDFVN-IKKQLEMLA-RMKVTHY----RF 599 + EG + T DF ++ ++ ++ +T + RF Sbjct: 33 WDAGDDVEENRTEAPEGTESEVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRF 92 Query: 600 ----------ALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHL 649 ++W ++ V + +S + I+ +T Y H H Sbjct: 93 ATVVEELFRDGVNWGRIVAFFEFGGV--MCVESVNREMSPLVDN-IALWMTEYLNRHLH- 148 Query: 650 GLPEPLLHADGW 661 + GW Sbjct: 149 ---TWIQDNGGW 157 >3CFV-B nrPDB Length = 414 Score = 29.9 bits (66), Expect = 5.5, Method: Composition-based stats. Identities = 8/41 (19%), Positives = 12/41 (29%) Query: 546 SDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQL 586 D L +W+ N V T C F + + Sbjct: 250 DDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 290 >1XC6-A nrPDB Length = 971 Score = 29.9 bits (66), Expect = 6.0, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 22/77 (28%), Gaps = 11/77 (14%) Query: 590 ARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGIS------AMVTLYY 643 + F +DWA + GN + + + + + GI + Sbjct: 46 KALGFNCVSFYVDWALL--EGNPGHYSAEGIFDLQPFFDAAKEAGIYLLARPGPYINAEV 103 Query: 644 PTHAHLGLPEPLLHADG 660 G P L DG Sbjct: 104 SGG---GFPGWLQRVDG 117 >5Y1U-A nrPDB Length = 456 Score = 29.5 bits (65), Expect = 7.5, Method: Composition-based stats. Identities = 8/41 (19%), Positives = 12/41 (29%) Query: 546 SDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQL 586 D L +W+ N V T C F + + Sbjct: 279 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 319 >4V2X-A nrPDB Length = 597 Score = 29.5 bits (65), Expect = 8.6, Method: Composition-based stats. Identities = 16/120 (13%), Positives = 39/120 (32%), Gaps = 25/120 (20%) Query: 135 EKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLY 194 + + + G + ++W + + L ++ + ++ ++ L+ Sbjct: 92 RELIEQIADEGYKSIRIPVTWENRIGGAPDYPIDPQFLNRVDQVVQWALEEDLYVMINLH 151 Query: 195 HWDLPLALQE---KYGG--------WKNDTIIDIFNDY-ATYCFQMFGDRVKYWITIHNP 242 H D L + E Y G W + + + F DY F+ ++ P Sbjct: 152 H-DSWLWIYEMEHNYNGVMVKYRSLW--EQLSNHFKDYPTKLMFES----------VNEP 198 >4XX6-A nrPDB Length = 321 Score = 29.1 bits (64), Expect = 9.4, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 21/66 (31%), Gaps = 12/66 (18%) Query: 422 DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEW------QDAYTIR 475 S+ E Y + V+ A + G T W + D + W + Y + Sbjct: 248 PSQADIEQQARDY------ATVVNACKAQGAACVGITTWGITDLYSWIPSTYPGEGYALL 301 Query: 476 RGLFYV 481 YV Sbjct: 302 FDDNYV 307 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.146 0.493 Lambda K H 0.267 0.0451 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 50,449,933 Number of Sequences: 36641 Number of extensions: 2530103 Number of successful extensions: 8284 Number of sequences better than 10.0: 116 Number of HSP's better than 10.0 without gapping: 134 Number of HSP's successfully gapped in prelim test: 47 Number of HSP's that attempted gapping in prelim test: 6086 Number of HSP's gapped (non-prelim): 437 length of query: 1044 length of database: 10,336,785 effective HSP length: 107 effective length of query: 937 effective length of database: 6,416,198 effective search space: 6011977526 effective search space used: 6011977526 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 65 (29.5 bits)