BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q80WG5 (810 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6O00-A nrPDB 1666 0.0 4R6F-A nrPDB 74 3e-13 6HLU-A nrPDB 72 1e-12 5XJX-C nrPDB 58 2e-08 6HKW-A nrPDB 56 7e-08 4QDH-A nrPDB 55 1e-07 4ECN-A nrPDB 55 1e-07 5ZSN-B nrPDB 51 2e-06 4PUF-A nrPDB 50 3e-06 2XOT-A nrPDB 49 7e-06 3T6Q-A nrPDB 49 9e-06 5LFN-A nrPDB 48 2e-05 3B2D-A nrPDB 47 5e-05 3RG1-A nrPDB 46 6e-05 5Y31-B nrPDB 45 1e-04 2Z7X-B nrPDB 45 1e-04 5MX0-A nrPDB 45 2e-04 5YQ5-A nrPDB 44 2e-04 4R08-A nrPDB 44 3e-04 1OGQ-A nrPDB 44 4e-04 1XCD-A nrPDB 43 5e-04 3ULU-A nrPDB 42 0.001 3G06-A nrPDB 42 0.001 6GFF-I nrPDB 41 0.003 3J0A-A nrPDB 39 0.006 3CIG-A nrPDB 38 0.016 3CVR-A nrPDB 38 0.017 2FT3-A nrPDB 37 0.025 3A7C-A nrPDB 37 0.035 3A79-B nrPDB 36 0.053 5Y3M-A nrPDB 36 0.082 2V9T-B nrPDB 35 0.11 5Y3K-A nrPDB 34 0.20 4AY9-X nrPDB 34 0.23 5D3I-A nrPDB 34 0.33 5GY2-A nrPDB 32 1.0 3V44-A nrPDB 32 1.1 1XWD-C nrPDB 32 1.1 5KH1-A nrPDB 32 1.3 2Z80-A nrPDB 32 1.4 3G04-C nrPDB 32 1.4 2Z7X-A nrPDB 31 2.0 3TSR-E nrPDB 31 2.2 3OT5-A nrPDB 31 2.4 5YXM-A nrPDB 30 2.9 1DCE-A nrPDB 30 3.0 1M9S-A nrPDB 30 4.1 1JL5-A nrPDB 29 8.0 3WPI-A nrPDB 29 8.7 2BNH-A nrPDB 29 9.1 >6O00-A nrPDB Length = 820 Score = 1666 bits (4315), Expect = 0.0, Method: Compositional matrix adjust. Identities = 810/810 (100%), Positives = 810/810 (100%) Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60 Query: 61 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW Sbjct: 61 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120 Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE Sbjct: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180 Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA Sbjct: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240 Query: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE 300 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE Sbjct: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE 300 Query: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES Sbjct: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360 Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL Sbjct: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420 Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA Sbjct: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480 Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL Sbjct: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540 Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR Sbjct: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600 Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 Query: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK Sbjct: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780 Query: 781 RSGLVVEEDLFSTLPPEVKERLWRADKEQA 810 RSGLVVEEDLFSTLPPEVKERLWRADKEQA Sbjct: 781 RSGLVVEEDLFSTLPPEVKERLWRADKEQA 810 >4R6F-A nrPDB Length = 331 Score = 73.9 bits (180), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 124/266 (46%), Gaps = 30/266 (11%) Query: 533 RYIVIDG--------LRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIV 583 RY+ + G L+EL L L L +N L LPQ V + +L L+++N + Sbjct: 66 RYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLP 125 Query: 584 LNSLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTI-------EEIISF 635 +++ +LT L L ++ I + L NL ++L NNL + I Sbjct: 126 QGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFL 185 Query: 636 QHLHRLTCLKLWYNHIAYIPIQI-GNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLS 693 + L LT L L N IP ++ +LT+L L L+ N I I Q+ L L+LS Sbjct: 186 KGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLS 245 Query: 694 HNNLTFL-----PAD----IGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVL 743 HNNL L P + L NL L +++N + +P E+F+ L L+L NN L Sbjct: 246 HNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQL 305 Query: 744 QSLPSRVGE-LTNLTQIELRGNRLEC 768 SLP V E LTNL + L N+L+ Sbjct: 306 TSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 33.9 bits (76), Expect = 0.33, Method: Compositional matrix adjust. Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 2/71 (2%) Query: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLF 791 +R L LG N L + S + ELTNL + L N+LE LP + E L + L + + Sbjct: 64 NVRYLALGGNKLHDI-SALKELTNLGWLNLSNNQLETLPQGVFE-KLTNLTTLNLSNNQL 121 Query: 792 STLPPEVKERL 802 ++LP V ERL Sbjct: 122 TSLPQGVFERL 132 >6HLU-A nrPDB Length = 974 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 97/314 (30%), Positives = 150/314 (47%), Gaps = 37/314 (11%) Query: 465 IAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI-PLWIYSLKTLEELHL 523 +A L L LWL+ AP + ++L L + I +I PL SLK+L EL L Sbjct: 131 LASLNSLSMLWLFGNKISDIAPLESL--KSLTELQLSSNQITDIAPL--ASLKSLTELSL 186 Query: 524 TGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG-----VHLQKLSI-NNE 577 +GN ++ I L LK L L L SN +TD+ L +LS+ +N+ Sbjct: 187 SGNNISD------IAPLESLKSLTELSLSSN------QITDIAPLASLKSLTELSLSSNQ 234 Query: 578 GTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637 + + L SLK +LTEL+L R + I + SL +L E+ L N I +I Sbjct: 235 ISDIAPLESLK---SLTELQLSRNQISDIA-PLESLKSLTELQLSSNQ---ITDIAPLAS 287 Query: 638 LHRLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNN 696 L LT L+L N I+ I P++ +L +L +L+LN N+I I L L L+LS N Sbjct: 288 LKSLTELQLSRNQISDIAPLE--SLNSLSKLWLNGNQITDI-APLASLNSLTELELSSNQ 344 Query: 697 LTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756 +T + A + L++L L +++N+I + P N + P + L +L Sbjct: 345 ITDI-APLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISP--LASLNSL 401 Query: 757 TQIELRGNRLECLP 770 T ++R N ++ LP Sbjct: 402 TGFDVRRNPIKRLP 415 >5XJX-C nrPDB Length = 433 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 128/289 (44%), Gaps = 26/289 (8%) Query: 533 RYIVIDGLRELKRLKVLRLKSNLSKLPQVV----TDVGVHLQKLSINNEGTKLIVLNSLK 588 R V + L LK LK L L + PQ + +G LQ L + G + + L Sbjct: 94 RSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG 153 Query: 589 KMVNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLW 647 + NL L+L + L IP S L+ +DL N L I F L L+ L L Sbjct: 154 NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL--TGSIPGFV-LPALSVLDLN 210 Query: 648 YNHI-AYIPIQIGNLTNLERLYLNRNKIEK-IPTQLFYCRKLRYLDLSHNNLTF-LPADI 704 N + +P + + +L ++ L+RN++ IP + +L LDLS+N L+ P+ + Sbjct: 211 QNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSL 270 Query: 705 GLLQNLQNLAVTANR--IEALPPELFQC-RKLRALHLGN-NVLQSLPSRVGELTNLTQIE 760 L +LQ L + N +P F+ + L L L N N+ S+P + L +L + Sbjct: 271 QGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLH 330 Query: 761 LRGNRLECLPVELGECPLLKR-----SGLVVEEDLFSTLPPEVKERLWR 804 L GN L GE PL R S L + ++ + P ++ +WR Sbjct: 331 LEGNNLT------GEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWR 373 Score = 35.4 bits (80), Expect = 0.10, Method: Compositional matrix adjust. Identities = 79/282 (28%), Positives = 114/282 (40%), Gaps = 36/282 (12%) Query: 464 SIAQLTGLKELWLYHTAAKIEA--PA-LAFLRENLRALHIKFTD-IKEIPLWIYSLKTLE 519 S+ +L LK L+ Y + PA L L +L+ L ++ + IP + +L L+ Sbjct: 100 SLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLK 159 Query: 520 EL-----HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSI 574 L HL G++ NR+ GLR L L RL ++ G L LS+ Sbjct: 160 VLDLHKNHLNGSIPLSFNRF---SGLRSLD-LSGNRLTGSIP---------GFVLPALSV 206 Query: 575 NNEGTKLIVLNSLKKMVNLTELELIRCDLER------IPHSIFSLHNLQEIDLKDNNLKT 628 + L+ + + L I+ DL R IP SI L+ L +DL N L Sbjct: 207 LDLNQNLLTGPVPPTLTSCGSL--IKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSG 264 Query: 629 IEEIISFQHLHRLTCLKLWYNHIAYIPI---QIGNLTNLERLYLNRNKIE-KIPTQLFYC 684 S Q L+ L L L N I L NL L L+ I+ IP L Sbjct: 265 PFPS-SLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL 323 Query: 685 RKLRYLDLSHNNLTF-LPADIGLLQNLQNLAVTANRIEALPP 725 LR L L NNLT +P + +++L L + N + P Sbjct: 324 NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVP 365 >6HKW-A nrPDB Length = 363 Score = 55.8 bits (133), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 119/240 (49%), Gaps = 28/240 (11%) Query: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVN---L 593 I+G LK++K L L+ NL K + + ++ L++L + + N +KK+ N L Sbjct: 94 IEGFEVLKKVKTLCLRQNLIKCIENLEELQ-SLRELDLYD--------NQIKKIENLEAL 144 Query: 594 TELEL--IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 TELE+ I +L R + L L+++ L +N + IE + +LH+L L+L N I Sbjct: 145 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE---NLSNLHQLQMLELGSNRI 201 Query: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711 I I LTNLE L+L +NKI K+ L L L + N LT + LQNL Sbjct: 202 RAIE-NIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKIEG----LQNLV 255 Query: 712 NLA---VTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 NL ++ N IE + L KL L + +N ++ + + + LT L + + N LE Sbjct: 256 NLRELYLSHNGIEVIEG-LENNNKLTMLDIASNRIKKIEN-ISHLTELQEFWMNDNLLES 313 >4QDH-A nrPDB Length = 438 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/194 (31%), Positives = 89/194 (45%), Gaps = 19/194 (9%) Query: 594 TELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652 T LEL L+ +PH +F L L ++ L NNL TI+ + F +L RL CL L +N IA Sbjct: 38 TRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEM-FVNLSRLQCLSLSHNSIA 96 Query: 653 YI--PIQIGNLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFLPADIG---- 705 Q LTNL+ L L+ NK++ + F +L+ LDLS+N+ F IG Sbjct: 97 QAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFS 156 Query: 706 ---LLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVG-------ELTN 755 L LQ+L++ N I +R L N + + G L+ Sbjct: 157 FVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSG 216 Query: 756 LTQIELRGNRLECL 769 L +++L N L L Sbjct: 217 LLKLDLSQNNLHIL 230 >4ECN-A nrPDB Length = 876 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 96/215 (44%), Gaps = 21/215 (9%) Query: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 +LE P S SL + ++ L D + + +F +LT LKL YN I IP Sbjct: 559 NLEEFPASA-SLQKMVKLGLLDCVHNKVRHLEAFGTNVKLTDLKLDYNQIEEIPEDFCAF 617 Query: 662 TN-LERLYLNRNKIEKIPTQLFYCRK---LRYLDLSHNNLTFLPADIGLLQ------NLQ 711 T+ +E L + NK++ IP +F + + +D S+N + +I N Sbjct: 618 TDQVEGLGFSHNKLKYIP-NIFNAKSVYVMGSVDFSYNKIGSEGRNISCSMDDYKGINAS 676 Query: 712 NLAVTANRIEALPPELFQCRK-LRALHLGNNVLQSLPS-----RVGELTN---LTQIELR 762 + ++ N I+ P ELF + + L NN++ S+P + G N LT I+LR Sbjct: 677 TVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLR 736 Query: 763 GNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPE 797 N+L L + L S + V + FS+ P + Sbjct: 737 FNKLTSLSDDFRATTLPYLSNMDVSYNCFSSFPTQ 771 Score = 35.4 bits (80), Expect = 0.089, Method: Compositional matrix adjust. Identities = 77/395 (19%), Positives = 141/395 (35%), Gaps = 116/395 (29%) Query: 423 NAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479 N +D ++ L+ ++ +PD ++DL EL+ L + + S AQ LK W Sbjct: 489 NLKDLTDVELYNCPNMTQLPDFLYDLPELQSLNIACNRGI----SAAQ---LKADWTRLA 541 Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539 + P ++ ++ + +++E P SA Sbjct: 542 DDEDTGPK-------IQIFYMGYNNLEEFP-----------------ASAS--------- 568 Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELI 599 L+++ +L +L N + HL+ N V LT+L+L Sbjct: 569 LQKMVKLGLLDCVHNKVR----------HLEAFGTN---------------VKLTDLKLD 603 Query: 600 RCDLERIPHSIFSLHN-LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658 +E IP + + ++ + N LK I I + + ++ + + YN I I Sbjct: 604 YNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNAKSVYVMGSVDFSYNKIGSEGRNI 663 Query: 659 G------NLTNLERLYLNRNKIEKIPTQLFYCRK-------------------------- 686 N + L+ N+I+K PT+LF Sbjct: 664 SCSMDDYKGINASTVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKDGN 723 Query: 687 ------LRYLDLSHNNLTFLPADI--GLLQNLQNLAVTANRIEALPPELFQCRKLRALHL 738 L +DL N LT L D L L N+ V+ N + P + +L+A + Sbjct: 724 YKNTYLLTTIDLRFNKLTSLSDDFRATTLPYLSNMDVSYNCFSSFPTQPLNSSQLKAFGI 783 Query: 739 -------GNNVLQSLPSRVGELTNLTQIELRGNRL 766 GN +L+ P+ + +L Q+++ N + Sbjct: 784 RHQRDAEGNRILRQWPTGITTCPSLIQLQIGSNDI 818 >5ZSN-B nrPDB Length = 823 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 118/260 (45%), Gaps = 37/260 (14%) Query: 527 LSAENNRYIVID--GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVL 584 L NNR ++ EL++L+VL + SN + Q I + +L Sbjct: 525 LDFSNNRLDLLHSTAFEELRKLEVLDISSN-----------SHYFQSEGITH------ML 567 Query: 585 NSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI------EEIISFQHL 638 N K + L +L + D+ +L+ ++ + N+L + + F++L Sbjct: 568 NFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNL 627 Query: 639 HRLTCLKLWYNHIAYIPIQI--GNLTNLERLYLNRNKIEK-IPTQLFYCRKLRYLDLSHN 695 +L L + N ++++P + G NL+ L L +N ++ I +L Y + L LDLSHN Sbjct: 628 LKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHN 687 Query: 696 NLTFLPADIG-LLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQ-----SLPS 748 LT +P + ++L+NL + N+I +L Q +LR L L +N +Q S P Sbjct: 688 QLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPE 747 Query: 749 RVGELTNLTQIELRGNRLEC 768 V L NL + L NR C Sbjct: 748 NV--LNNLKMLLLHHNRFLC 765 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 108/429 (25%), Positives = 169/429 (39%), Gaps = 98/429 (22%) Query: 438 IPDTVFD-LVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAPALAFLR--E 493 IP FD L EL+VL+L +PP + L+EL L E FL Sbjct: 259 IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLP 318 Query: 494 NLRALHIKFTDIKEIPLWIY-----------SLKTLEELHLTGNLSAENNRYIVIDGLRE 542 NL L + F L +Y SLK+L+ L + G + E + + L Sbjct: 319 NLIQLDLSFN----FELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSF-QLSPLHN 373 Query: 543 LKRLKVLRLKSNLSKLPQV----------VTDVGVHLQKLSINNEGTKLIVLNSLKKMVN 592 L+ L+VL L +N K+ + V D+ V+ I+ G L+ S + Sbjct: 374 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVN----KISPSGDSLVPRGSSNARTS 429 Query: 593 --------LTELELIRCDLE----RIPHSIFSLHNLQE--------IDLKDNNLKTIEEI 632 L +L R D R + S ++QE +DL N++ I+ Sbjct: 430 VESYEPQVLEQLYYFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKSS 489 Query: 633 ISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692 FQHL L CL L N I+ LN ++ + + +LRYLD Sbjct: 490 -DFQHLSFLKCLNLSGNLISQT--------------LNGSEFQPLA-------ELRYLDF 527 Query: 693 SHNNLTFLPAD-IGLLQNLQNLAVTAN----RIEALPPELFQCRKLRALH---LGNNVLQ 744 S+N L L + L+ L+ L +++N + E + L + L+ L + +N + Sbjct: 528 SNNRLDLLHSTAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS 587 Query: 745 SLPSRVGELTNLTQIELRGNRLECL--------------PVELGECPLLKRSGLVVEEDL 790 S SR E +L +E RGN L+ L ++L E + K S + + Sbjct: 588 SSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGV 647 Query: 791 FSTLPPEVK 799 F +PP +K Sbjct: 648 FDGMPPNLK 656 Score = 30.4 bits (67), Expect = 3.5, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 39/185 (21%) Query: 609 SIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLY 668 + +L L+ + LKDNN+ T+ ++ LT L L+ N IA IQ + NL +L Sbjct: 177 AFLNLTKLKVLSLKDNNVTTVPTVLP----STLTELYLYNNMIA--EIQEDDFNNLNQLQ 230 Query: 669 LNRNKIEKIPTQLFYCRKLRYLDLSHN--NLTFLPADIGLLQNLQNLAVTANRIEALPPE 726 + LDLS N P +N L + N +AL Sbjct: 231 I--------------------LDLSGNCPRCYNAPFPCTPCKNNSPLQIPVNAFDAL--- 267 Query: 727 LFQCRKLRALHLGNNVLQSLPSR-VGELTNLTQIELRGNRLECLPVELGECPLLKRSGLV 785 +L+ L L +N LQ +P R + NL +++L N L E+G+ L + Sbjct: 268 ----TELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQN---FLAKEIGDAKFLHFLPNL 320 Query: 786 VEEDL 790 ++ DL Sbjct: 321 IQLDL 325 >4PUF-A nrPDB Length = 637 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/188 (30%), Positives = 95/188 (50%), Gaps = 18/188 (9%) Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673 +N E+ LK L TI I Q +T L L N + +P + N++ LY N N+ Sbjct: 50 NNKTELRLKILGLTTIPAYIPEQ----ITTLILDNNELKSLPENLQG--NIKTLYANSNQ 103 Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKL 733 + IP L ++ ++LS N +T LP L LQ+L + N+I LP L + +L Sbjct: 104 LTSIPATL--PDTIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPE--EL 157 Query: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK--RSGLVVEEDLF 791 R L + +N +++LP+ + + +T + ++ N L LP L P LK +G L Sbjct: 158 RYLSVYDNSIRTLPAHLP--SEITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLP 213 Query: 792 STLPPEVK 799 ++LPPE++ Sbjct: 214 ASLPPELQ 221 >2XOT-A nrPDB Length = 361 Score = 49.3 bits (116), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/119 (34%), Positives = 61/119 (51%), Gaps = 7/119 (5%) Query: 589 KMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLW 647 ++ NL L L L I F + NL+ +DL N+L T++E + F L L L L+ Sbjct: 62 RLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFL-FSDLQALEVLLLY 120 Query: 648 YNHIAYIPIQ-IGNLTNLERLYLNRNKIEKIPTQLF----YCRKLRYLDLSHNNLTFLP 701 NHI + ++ L++LYL++N+I + P +L KL LDLS N L LP Sbjct: 121 NNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLP 179 >3T6Q-A nrPDB Length = 606 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 48/161 (29%), Positives = 75/161 (46%), Gaps = 9/161 (5%) Query: 586 SLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEE--IISFQHLHRLT 642 + +++NLT L+L RC + I F S H L + L N L + E + + L L Sbjct: 52 TFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLF 111 Query: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP-TQLFYCRKLRYLDLSHNNLTFLP 701 ++ + I +IP+ N LE LYL N I I + F KL+ LD +N + +L Sbjct: 112 FIQTGISSIDFIPLH--NQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLS 169 Query: 702 A-DIGLLQNLQNLA--VTANRIEALPPELFQCRKLRALHLG 739 D+ LQ NL+ + N I + P F ++L+ G Sbjct: 170 KEDMSSLQQATNLSLNLNGNDIAGIEPGAFDSAVFQSLNFG 210 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 36/62 (58%), Gaps = 1/62 (1%) Query: 663 NLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIE 721 ++E + L ++ I + F+C L+ LDL+ +L+ LP+ + L L+ L ++AN+ E Sbjct: 255 SVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFE 314 Query: 722 AL 723 L Sbjct: 315 NL 316 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 80/310 (25%), Positives = 126/310 (40%), Gaps = 64/310 (20%) Query: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGN-------LSAENN---RYIVIDGLRELK 544 L+ L + T + E+P + L TL++L L+ N +SA N ++ I G K Sbjct: 280 LQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKG--NTK 337 Query: 545 RLKV----LRLKSNLSKLPQVVTDVGV------------HLQKLSINNEGTKLIVLNSLK 588 RL++ L NL +L D+ HLQ L+++ + + K Sbjct: 338 RLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFK 397 Query: 589 K--MVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646 + + L +L R ++ +LH L+ ++L + L E + F L L L L Sbjct: 398 ECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQL-FDGLPALQHLNL 456 Query: 647 WYNHIAYIPIQIGN----LTNLERLYLNRNKIEKIPTQLFYCRKL-RYLDLSHNNLTFLP 701 NH IQ N L LE L L+ + I F K+ ++DLSHN LT Sbjct: 457 QGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLT--- 513 Query: 702 ADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHL---GNNVLQSLPSRVGELTNLTQ 758 ++ IEAL L+ ++L N++ LPS + L+ Sbjct: 514 ---------------SSSIEAL-------SHLKGIYLNLASNHISIILPSLLPILSQQRT 551 Query: 759 IELRGNRLEC 768 I LR N L+C Sbjct: 552 INLRQNPLDC 561 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 51/177 (28%), Positives = 71/177 (40%), Gaps = 32/177 (18%) Query: 479 TAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVID 538 T A E P L L +L +K D + ++ LK L H ++S+E + D Sbjct: 393 TEAFKECPQLELL--DLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQ----LFD 446 Query: 539 GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL 598 GL L+ L + G H K +I NSL+ + L L L Sbjct: 447 GLPALQHLNL----------------QGNHFPKGNIQKT-------NSLQTLGRLEILVL 483 Query: 599 IRCDLERI-PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI 654 CDL I H+ SL + +DL N L T I + HL + L L NHI+ I Sbjct: 484 SFCDLSSIDQHAFTSLKMMNHVDLSHNRL-TSSSIEALSHLKGIY-LNLASNHISII 538 >5LFN-A nrPDB Length = 337 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 75/279 (26%), Positives = 110/279 (39%), Gaps = 71/279 (25%) Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVL----------NSLKKMVNLTELELIRCDLER 605 S L V+ D V LQK+ +E TKL+ L NS + M NL L L C + Sbjct: 9 SDLQHVICD-KVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIRE 67 Query: 606 IPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI-GNLTN 663 + F L L + L N+++ + +F L LT L L +N + +P + L N Sbjct: 68 VAAGAFRGLKQLIYLYLSHNDIRVLR-AGAFDDLTELTYLYLDHNKVTELPRGLLSPLVN 126 Query: 664 LERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLLQNLQNLA-------- 714 L L LN NKI ++ F K LR+L LS N L+ L G L +++NLA Sbjct: 127 LFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQP--GALDDVENLAKFHVDRNQ 184 Query: 715 -------------------VTANRIEALPPELFQC------------------------- 730 ++ N ++++P FQ Sbjct: 185 LSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLG 244 Query: 731 -RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 L+ +HL NN L LPS +L + L N +C Sbjct: 245 VTTLKHVHLENNRLNQLPSNF-PFDSLETLALTNNPWKC 282 >3B2D-A nrPDB Length = 603 Score = 46.6 bits (109), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 45/161 (27%), Positives = 78/161 (48%), Gaps = 9/161 (5%) Query: 586 SLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEE--IISFQHLHRLT 642 + +++NLT L+L RC + I F S H L + L N L + E + + L L Sbjct: 49 TFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLF 108 Query: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP-TQLFYCRKLRYLDLSHNNLTFLP 701 ++ +++ +IP+ NL NLE LYL N I I + F R L+ LD +N + ++ Sbjct: 109 LIQTGISNLEFIPVH--NLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYIS 166 Query: 702 -ADIGLLQNLQNLAV--TANRIEALPPELFQCRKLRALHLG 739 D+ L+ NL++ N ++ + F ++L+ G Sbjct: 167 REDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFG 207 Score = 33.1 bits (74), Expect = 0.54, Method: Compositional matrix adjust. Identities = 91/361 (25%), Positives = 143/361 (39%), Gaps = 79/361 (21%) Query: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI--EAPALAFLR-- 492 GI FD + L P++++ + Q + + LWL T I E + A L+ Sbjct: 190 GIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLG-TFEDIDDEDISSAMLKGL 248 Query: 493 -----ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLK 547 E+L +F+DI ++ L+EL LT + + G++ L LK Sbjct: 249 CEMSVESLNLQEHRFSDISSTTFQCFT--QLQELDLTAT-----HLKGLPSGMKGLNLLK 301 Query: 548 VLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKL-IVLNSLKKMVNLTELELIRCDLER 605 L L N +L Q+ L L I KL + + L+K+ NL L+L D+E Sbjct: 302 KLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEA 361 Query: 606 IPHSIFSLHNL---QEIDLKDNNLKTIE----------EIIS--------------FQHL 638 L NL Q ++L N ++ E++ FQ+L Sbjct: 362 SDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNL 421 Query: 639 HRLTCLKLWY--------NHIAYIPI-----------QIGNLT---------NLERLYLN 670 H L L L Y + +A +P+ Q G +T +LE L L+ Sbjct: 422 HFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILS 481 Query: 671 RNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQN--LAVTANRIEALPPEL 727 + I Q F+ K+ ++DLSHN+LT I L +L+ L + AN I + P L Sbjct: 482 SCGLLSIDQQAFHSLGKMSHVDLSHNSLTC--DSIDSLSHLKGIYLNLAANSINIISPRL 539 Query: 728 F 728 Sbjct: 540 L 540 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 56/124 (45%), Gaps = 21/124 (16%) Query: 664 LERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEA 722 +E L L ++ I + F C +L+ LDL+ +L LP+ + L L+ L ++ N + Sbjct: 253 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQ 312 Query: 723 LP----------PELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE---CL 769 L L+ ++ LHLG L+ +L NL ++L N +E C Sbjct: 313 LCQISAANFPSLTHLYIRGNVKKLHLGVGCLE-------KLGNLQTLDLSHNDIEASDCC 365 Query: 770 PVEL 773 ++L Sbjct: 366 SLQL 369 >3RG1-A nrPDB Length = 612 Score = 46.2 bits (108), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 78/164 (47%), Gaps = 9/164 (5%) Query: 586 SLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEE--IISFQHLHRLT 642 + +++NL L+L RC + + F S H L I L N L + E + + L L Sbjct: 51 TFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLF 110 Query: 643 CLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP-TQLFYCRKLRYLDLSHNNLTFLP 701 + +++ +IP+ NL NLE L+L N I I + F + L+ LD +N + ++ Sbjct: 111 LTQTGISNLEFIPVH--NLENLESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYIS 168 Query: 702 -ADIGLLQNLQNLAV--TANRIEALPPELFQCRKLRALHLGNNV 742 D L+ NL++ N I+ + P F + ++L G ++ Sbjct: 169 RKDTNSLEQATNLSLNFNGNDIKGIEPGAFISKIFQSLKFGGSL 212 Score = 33.5 bits (75), Expect = 0.37, Method: Compositional matrix adjust. Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 11/132 (8%) Query: 605 RIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL-- 661 + PHS F +LH L+ ++L L T + + L L L L N I NL Sbjct: 414 KAPHSPFQNLHLLRVLNLSHCLLDTSNQHL-LAGLQDLRHLNLQGNSFQDGSISKTNLLQ 472 Query: 662 --TNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQN--LAVT 716 +LE L L+ + I Q F+ R + +LDLSHN+LT D L +L+ L + Sbjct: 473 MVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDA--LSHLKGLYLNMA 530 Query: 717 ANRIEALPPELF 728 +N I +PP L Sbjct: 531 SNNIRIIPPHLL 542 Score = 29.3 bits (64), Expect = 6.5, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 55/115 (47%), Gaps = 18/115 (15%) Query: 664 LERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEA 722 +E + L +++ + + F C +++ LDL+ +L LP+ I + +L+ L + AN + Sbjct: 255 VESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQ 314 Query: 723 LPP----------ELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767 L +L+ +R L LG L+ +L NL +++L + +E Sbjct: 315 LCQINAASFPSLRDLYIKGNMRKLDLGTRCLE-------KLENLQKLDLSHSDIE 362 >5Y31-B nrPDB Length = 544 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/131 (30%), Positives = 64/131 (48%), Gaps = 18/131 (13%) Query: 681 LFYCRKLRYLDLSHNNLTFLPAD--IGLLQNLQNLAVTANRIEALPPELFQC-RKLRALH 737 + L+ L + N+ + D IGL +L+ L + N I+++ F+ + L L Sbjct: 67 FLFTPSLQLLLFTSNSFDVISDDAFIGL-PHLEYLFIENNNIKSISRHTFRGLKSLIHLS 125 Query: 738 LGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVELGECPL------LKRSGLVVEEDL 790 L NN LQ+LP + + L +LT ++LRGN C +C L L + V ED+ Sbjct: 126 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC------DCKLKWLVEWLGHTNATV-EDI 178 Query: 791 FSTLPPEVKER 801 + PPE K+R Sbjct: 179 YCEGPPEYKKR 189 >2Z7X-B nrPDB Length = 520 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 69/122 (56%), Gaps = 16/122 (13%) Query: 659 GNLTNLERLYLNRN------KIEKIPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNL 710 G+LT LE L L N KI ++ TQ+ + L+ LD+S N++++ D ++L Sbjct: 345 GHLTELETLILQMNQLKELSKIAEMTTQM---KSLQQLDISQNSVSYDEKKGDCSWTKSL 401 Query: 711 QNLAVTANRIEALPPELFQC--RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 +L +++N L +F+C +++ L L +N ++S+P +V +L L ++ + N+L+ Sbjct: 402 LSLNMSSN---ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKS 458 Query: 769 LP 770 +P Sbjct: 459 VP 460 Score = 35.8 bits (81), Expect = 0.067, Method: Compositional matrix adjust. Identities = 27/88 (30%), Positives = 50/88 (56%), Gaps = 4/88 (4%) Query: 639 HRLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNN 696 + T L + N+I+ + I +L+ L L ++ N+I+ + +F + ++L YLDLSHN Sbjct: 21 QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 80 Query: 697 LTFLPADIGLLQNLQNLAVTANRIEALP 724 L + + NL++L ++ N +ALP Sbjct: 81 LVKISCHPTV--NLKHLDLSFNAFDALP 106 >5MX0-A nrPDB Length = 362 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 111/247 (44%), Gaps = 45/247 (18%) Query: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKT-LEELHLTGN-LSAENNRYIVIDGLRELKR 545 L F+ ++ ++ + I I ++ T L + L GN ++++ V LR L+R Sbjct: 86 LPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLER 145 Query: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 L + +NL+++P + L++L +++ + N+L+ + NLT L L +++ Sbjct: 146 LYLDH--NNLTRMPGPLPRS---LRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQE 200 Query: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLE 665 + S+ L +L +DL YNH+ +P G + LE Sbjct: 201 VGSSMRGLRSLILLDLS-------------------------YNHLRKVP--DGLPSALE 233 Query: 666 RLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTA------N 718 +LY+ N + +P F KL Y+ LSHN+LT + GL N N + N Sbjct: 234 QLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLT----NNGLASNTFNSSSLLELDLSYN 289 Query: 719 RIEALPP 725 +++ +PP Sbjct: 290 QLQKIPP 296 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 74/145 (51%), Gaps = 13/145 (8%) Query: 604 ERIPHSIFS-LHNLQEIDLKDNNLKTIEEII--SFQHLHRLTCLKLWYNHIAYIPIQ-IG 659 +++ +FS L +L+ + L NNL + + S + LH L +N I+ +P + Sbjct: 130 DKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELH------LDHNQISRVPNNALE 183 Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANR 719 L NL LYL N+I+++ + + R L LDLS+N+L +P GL L+ L + N Sbjct: 184 GLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD--GLPSALEQLYMEHNN 241 Query: 720 IEALPPELFQ-CRKLRALHLGNNVL 743 + +P F+ KL + L +N L Sbjct: 242 VYTVPDSYFRGAPKLLYVRLSHNSL 266 >5YQ5-A nrPDB Length = 430 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 58/267 (21%) Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT---AAKIEAPALAFL 491 L IP+ + +L L+ I VT S T LKE+ L H + KI+ A L Sbjct: 81 LKTIPNIPMHIQQL-YLQFNEIEAVTAN-SFINATHLKEINLSHNKIKSQKIDYGVFAKL 138 Query: 492 RENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRL----- 546 NL LH++ +++E P + K+LE L L G + +DGL L L Sbjct: 139 -PNLLQLHLEHNNLEEFPFPL--PKSLERL-LLGYNEISKLQTNAMDGLVNLTMLDLCYN 194 Query: 547 ----------------KVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKM 590 K+++L ++L + + L LS+ N I K+ Sbjct: 195 YLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKL 254 Query: 591 VNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 L L + L+ IP++IF+L N+ E+ + N LK Sbjct: 255 PKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQ---------------------- 292 Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKI 677 YIP NLE LYL N+IEK+ Sbjct: 293 AFYIP------RNLEHLYLQNNEIEKM 313 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 118/240 (49%), Gaps = 26/240 (10%) Query: 494 NLRALHIKFTDIKEIPLWIYSLKT-LEELHLTGN-LSAENNRYIVIDGLRELKRLKVLRL 551 +++ L+++F +I+ + + T L+E++L+ N + ++ Y V L L +L + Sbjct: 90 HIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEH- 148 Query: 552 KSNLSKLPQVVTDVGVHLQKLSIN-NEGTKLIVLNSLKKMVNLTELELIRCDLER--IPH 608 +NL + P + L++L + NE +KL N++ +VNLT L+L L + Sbjct: 149 -NNLEEFPFPLPKS---LERLLLGYNEISKLQT-NAMDGLVNLTMLDLCYNYLHDSLLKD 203 Query: 609 SIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLER 666 IF+ + L +++L N L+++ + L L L N I+ IP + L L Sbjct: 204 KIFAKMEKLMQLNLCSNRLESMPPGLP----SSLMYLSLENNSISSIPEKYFDKLPKLHT 259 Query: 667 LYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT---FLPADIGLLQNLQNLAVTANRIEAL 723 L ++ NK++ IP +F + L + HN L ++P +NL++L + N IE + Sbjct: 260 LRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIP------RNLEHLYLQNNEIEKM 313 >4R08-A nrPDB Length = 811 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 8/142 (5%) Query: 635 FQHLHRLTCLKLWYNHIAYIPIQIG-NL-TNLERLYLNRNKIEKIP-TQLFYCRKLRYLD 691 F+ L LT L L N + +IP + NL +L L++N N ++ T L +L LD Sbjct: 613 FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLD 672 Query: 692 LSHNNLTFLPADIG-LLQNLQNLAVTANRIEALPPE-LFQCRKLRALHLGNNVLQSLPSR 749 L N L FL + +L+ L ++ NRI LP L + L+ L L +N+L+++ Sbjct: 673 LRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 732 Query: 750 VGEL---TNLTQIELRGNRLEC 768 E T L+ +EL GN EC Sbjct: 733 ALETKTTTKLSMLELHGNPFEC 754 Score = 33.1 bits (74), Expect = 0.46, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 94/213 (44%), Gaps = 28/213 (13%) Query: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN----HIAYIPIQ 657 + IPH ++ +DL +N L + + L L L L YN IA + Sbjct: 503 EFSAIPH-------VKYLDLTNNRLD-FDNASALTELSDLEVLDLSYNSHYFRIAGVTHH 554 Query: 658 ---IGNLTNLERLYLNRNKIEKIPTQL-FYCRKLRYLDLSHNNLTFLPAD-----IGLLQ 708 I N TNL+ L L+ N I + + + L L S N L L D I + + Sbjct: 555 LEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFK 614 Query: 709 NLQNLA---VTANRIEALPPELFQC--RKLRALHLGNNVLQSLP-SRVGELTNLTQIELR 762 L+NL ++ NR++ +P E F L LH+ +N+L+ + + + L ++LR Sbjct: 615 GLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLR 674 Query: 763 GNRLECLPVELGECPLLKRSGLVVEEDLFSTLP 795 GN+L L L + R+ L++ + S LP Sbjct: 675 GNKLLFLTDSLSDFTSSLRT-LLLSHNRISHLP 706 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 123/315 (39%), Gaps = 66/315 (20%) Query: 522 HLTGNLSAENNRYIVIDG-LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTK 580 H GN ++N + DG LK L+ L L+ N +LPQ+ + + L +LS+ Sbjct: 80 HQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDN--QLPQIPSGLPESLTELSLIQNNIY 137 Query: 581 LIVLNSLKKMVNLTELELI-------RCDLERIPHSIF-SLHN----------------- 615 I + +++NL L L C+ I +F +L N Sbjct: 138 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK 197 Query: 616 ----LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN-------HIAYIPIQIG----- 659 L+++ L + +K I E F+ L LT L L N +P G Sbjct: 198 LPSSLRKLFLSNTQIKYISE-EDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINI 256 Query: 660 ------NLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPAD---IGLLQN 709 NLT L L L+ + KI F L+ LDL N L A + +L Sbjct: 257 DRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPR 316 Query: 710 LQNLAVTANRIEALPPELFQCRK-------LRALHLGNNVLQSLPSR----VGELTNLTQ 758 L+ L ++ N I+ P+ + LRALHL V Q L + +L NL+ Sbjct: 317 LEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLST 376 Query: 759 IELRGNRLECLPVEL 773 I L N ++ + +L Sbjct: 377 INLGINFIKQIDFKL 391 >1OGQ-A nrPDB Length = 313 Score = 43.5 bits (101), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 52/169 (30%), Positives = 77/169 (45%), Gaps = 10/169 (5%) Query: 606 IPHSIFSLHNLQEIDLKDNNLKTI--EEIISFQHLHRLTCLKLWYNHI-AYIPIQIGNLT 662 +P SI SL NL I N + + SF L T + + N + IP NL Sbjct: 141 LPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKL--FTSMTISRNRLTGKIPPTFANL- 197 Query: 663 NLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI- 720 NL + L+RN +E + LF K + + L+ N+L F +GL +NL L + NRI Sbjct: 198 NLAFVDLSRNMLEGDASVLFGSDKNTQKIHLAKNSLAFDLGKVGLSKNLNGLDLRNNRIY 257 Query: 721 EALPPELFQCRKLRALHLG-NNVLQSLPSRVGELTNLTQIELRGNRLEC 768 LP L Q + L +L++ NN+ +P + G L N+ C Sbjct: 258 GTLPQGLTQLKFLHSLNVSFNNLCGEIP-QGGNLQRFDVSAYANNKCLC 305 Score = 38.1 bits (87), Expect = 0.016, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 56/147 (38%), Gaps = 26/147 (17%) Query: 654 IPIQIGNLTNLERLYLN--RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711 IP + NL L LY+ N + IP + +L YL ++H N++ Sbjct: 68 IPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVS------------- 114 Query: 712 NLAVTANRIEALPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRLE-CL 769 A+P L Q + L L N L +LP + L NL I GNR+ + Sbjct: 115 ---------GAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAI 165 Query: 770 PVELGECPLLKRSGLVVEEDLFSTLPP 796 P G L S + L +PP Sbjct: 166 PDSYGSFSKLFTSMTISRNRLTGKIPP 192 Score = 37.0 bits (84), Expect = 0.032, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 113/284 (39%), Gaps = 58/284 (20%) Query: 438 IPDTVFDLVELEVLKLELIPDVT--IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495 IP ++ +L L L + I ++ IPP+IA+LT L L++ HT Sbjct: 68 IPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVS------------- 114 Query: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555 IP ++ +KTL L + Y + G L ++ Sbjct: 115 ----------GAIPDFLSQIKTLVTLDFS---------YNALSG----------TLPPSI 145 Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLE-RIPHSIFSLH 614 S LP + VG+ I G S K+ T + + R L +IP + +L Sbjct: 146 SSLPNL---VGITFDGNRI--SGAIPDSYGSFSKL--FTSMTISRNRLTGKIPPTFANL- 197 Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674 NL +DL N L+ ++ F + L N +A+ ++G NL L L N+I Sbjct: 198 NLAFVDLSRNMLEGDASVL-FGSDKNTQKIHLAKNSLAFDLGKVGLSKNLNGLDLRNNRI 256 Query: 675 -EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTA 717 +P L + L L++S NNL +I NLQ V+A Sbjct: 257 YGTLPQGLTQLKFLHSLNVSFNNLC---GEIPQGGNLQRFDVSA 297 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 48/167 (28%), Positives = 74/167 (44%), Gaps = 9/167 (5%) Query: 606 IPHSIFSLHNLQEIDLKDNNLK-TIEEIISFQHLHRLTCLKLWYNHI-AYIPIQIGNLTN 663 IP +I L L + + N+ I + +S + L L YN + +P I +L N Sbjct: 93 IPPAIAKLTQLHYLYITHTNVSGAIPDFLS--QIKTLVTLDFSYNALSGTLPPSISSLPN 150 Query: 664 LERLYLNRNKIEK-IPTQLFYCRKL-RYLDLSHNNLTF-LPADIGLLQNLQNLAVTANRI 720 L + + N+I IP KL + +S N LT +P L NL + ++ N + Sbjct: 151 LVGITFDGNRISGAIPDSYGSFSKLFTSMTISRNRLTGKIPPTFANL-NLAFVDLSRNML 209 Query: 721 EALPPELFQCRK-LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766 E LF K + +HL N L +VG NL ++LR NR+ Sbjct: 210 EGDASVLFGSDKNTQKIHLAKNSLAFDLGKVGLSKNLNGLDLRNNRI 256 >1XCD-A nrPDB Length = 329 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 139/314 (44%), Gaps = 49/314 (15%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA-AKIEAPALAFLRENLRA 497 PDT L++L+ K+ I D L L L L + +KI A A L + L Sbjct: 52 PDTA--LLDLQNNKITEIKDG----DFKNLKNLHTLILINNKISKISPGAFAPLVK-LER 104 Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 L++ +KE+P + KTL+EL + N R V +GL ++ Sbjct: 105 LYLSKNQLKELPEKMP--KTLQELRVHEN-EITKVRKSVFNGLNQM-------------- 147 Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQ 617 +V ++G + K S G + + M L+ + + ++ IP + +L Sbjct: 148 ---IVVELGTNPLKSSGIENG-------AFQGMKKLSYIRIADTNITTIPQGLPP--SLT 195 Query: 618 EIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYLNRNKIEK 676 E+ L N + ++ S + L+ L L L +N I+ + + N +L L+LN NK+ K Sbjct: 196 ELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK 254 Query: 677 IPTQLFYCRKLRYLDLSHNNLT------FLPADIGLLQ-NLQNLAVTANRIE--ALPPEL 727 +P L + ++ + L +NN++ F P + + +++ +N ++ + P Sbjct: 255 VPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPST 314 Query: 728 FQCRKLR-ALHLGN 740 F+C +R A+ LGN Sbjct: 315 FRCVYVRAAVQLGN 328 Score = 42.4 bits (98), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 11/201 (5%) Query: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII 633 INN+ +K I + +V L L L + L+ +P + LQE+ + +N + + + + Sbjct: 84 INNKISK-ISPGAFAPLVKLERLYLSKNQLKELPEKMPK--TLQELRVHENEITKVRKSV 140 Query: 634 SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLFYCRKLRYL 690 F L+++ ++L N + I+ G +++L R I IP L L L Sbjct: 141 -FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGL--PPSLTEL 197 Query: 691 DLSHNNLTFL-PADIGLLQNLQNLAVTANRIEALP-PELFQCRKLRALHLGNNVLQSLPS 748 L N +T + A + L NL L ++ N I A+ L LR LHL NN L +P Sbjct: 198 HLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 257 Query: 749 RVGELTNLTQIELRGNRLECL 769 + + + + L N + + Sbjct: 258 GLADHKYIQVVYLHNNNISAI 278 >3ULU-A nrPDB Length = 694 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/161 (29%), Positives = 77/161 (47%), Gaps = 8/161 (4%) Query: 591 VNLTELELIRCDLERIPHSIFSLHN-LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN 649 N+T L L L R+P + F+ ++ L +D+ N + +E + Q L L L L +N Sbjct: 35 TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELC-QKLPMLKVLNLQHN 93 Query: 650 HIAYIPIQ-IGNLTNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLL 707 ++ + + TNL L+L N I+KI F +K L LDLSHN L+ + Sbjct: 94 ELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQ 153 Query: 708 QNLQNLAVTA-NRIEALPPE---LFQCRKLRALHLGNNVLQ 744 + + N+I+AL E +F L+ L L +N ++ Sbjct: 154 LENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK 194 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 10/76 (13%) Query: 685 RKLRYLDLSHNNLTFL------PADIGLLQNLQNLAV---TANRIEALPPELFQ-CRKLR 734 KL LDL HNNL L I L+ L +L + +N + +P E+F+ +L+ Sbjct: 514 EKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELK 573 Query: 735 ALHLGNNVLQSLPSRV 750 + LG N L +LP+ V Sbjct: 574 IIDLGLNNLNTLPASV 589 >3G06-A nrPDB Length = 622 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 21/164 (12%) Query: 615 NLQEIDLKDNNLKTIEEIIS-----FQHLHRLTCLKLWYNHIAYIPIQIGNLTNLE---- 665 LQE+ + DN L ++ + S + + ++LT L + + + + + L +L Sbjct: 142 GLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPS 201 Query: 666 ---RLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEA 722 +L+ N++ +P L+ L +S N LT LP L L+ L V+ NR+ + Sbjct: 202 ELYKLWAYNNRLTSLPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTS 255 Query: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766 LP L +L + N L LP + L++ T + L GN L Sbjct: 256 LP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPL 296 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 19/142 (13%) Query: 645 KLWY--NHIAYIPIQIGNLTNLERLYLNRNKIEKIPT-QLFYCRKLRYLDLSHNNLTFLP 701 KLW N + +P+ L+ L ++ N++ +P C+ Y +N LT LP Sbjct: 125 KLWIFGNQLTSLPVLP---PGLQELSVSDNQLASLPALPSELCKLWAY----NNQLTSLP 177 Query: 702 ADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761 L LQ L+V+ N++ +LP + KL A NN L SLP+ + L ++ + Sbjct: 178 M---LPSGLQELSVSDNQLASLPTLPSELYKLWAY---NNRLTSLPALP---SGLKELIV 228 Query: 762 RGNRLECLPVELGECPLLKRSG 783 GNRL LPV E L SG Sbjct: 229 SGNRLTSLPVLPSELKELMVSG 250 Score = 29.3 bits (64), Expect = 6.4, Method: Compositional matrix adjust. Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 15/80 (18%) Query: 695 NNLTFLPADIGLLQNLQNLAVTANRIEA---LPPELFQCRKLRALHLGNNVLQSLPSRVG 751 NNLT LPA L L+ L V+ N++ + LPP L + L + +N L LP+ Sbjct: 71 NNLTSLPA---LPPELRTLEVSGNQLTSLPVLPPGLLE------LSIFSNPLTHLPALP- 120 Query: 752 ELTNLTQIELRGNRLECLPV 771 + L ++ + GN+L LPV Sbjct: 121 --SGLCKLWIFGNQLTSLPV 138 >6GFF-I nrPDB Length = 618 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 104/390 (26%), Positives = 156/390 (40%), Gaps = 58/390 (14%) Query: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505 V +VL L +P V +PP L + I A L F LR L + +I Sbjct: 14 VSCQVLGLLQVPSV-LPPDTETLD-----LSGNQLRSILASPLGFYTA-LRHLDLSTNEI 66 Query: 506 KEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN--LSKLPQVV 562 + P +L LE L L N A + GL L R+ L L N S L + + Sbjct: 67 SFLQPGAFQALTHLEHLSLAHNRLAMAT-ALSAGGLGPLPRVTSLDLSGNSLYSGLLERL 125 Query: 563 TDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL---IRCDLE--------RIPH--- 608 L LS+ + ++ + M L +L+L + D+E R+ H Sbjct: 126 LGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNL 185 Query: 609 --------SIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 S FSL L+ +DL N+++ + Q +LT L L N + + P + Sbjct: 186 SRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP----D 241 Query: 661 LTNLERL-YLN-RNKIEKIPTQLFYCRKLRY----------LDLSHNNLTFLPADIGLLQ 708 L L RL YLN N + ++PT K + L N + P L Sbjct: 242 LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP-----LS 296 Query: 709 NLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPS-RVGELTNLTQIELRGNRL 766 L NL ++ N IE +P + L L+L N L++ + R+G L L ++L N L Sbjct: 297 QLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 356 Query: 767 ECLPVELGECPLLKRSGLVVEEDLFSTLPP 796 E L ELG L L+++ + LPP Sbjct: 357 ETL--ELGARALGSLRTLLLQGNALRDLPP 384 Score = 38.1 bits (87), Expect = 0.016, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 126/289 (43%), Gaps = 36/289 (12%) Query: 532 NRYIVIDGLRELKRLKVLRLKSNLSKLPQVVT--DVGVHLQKLSINNEGTKLIVLN---- 585 N+ + L L RL L L +NL +LP G+H +EG + L+ Sbjct: 234 NKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIH-----APSEGWSALPLSAPSG 288 Query: 586 --SLKKMVNLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 S + + L L+L ++E IP S L +L ++L N L+T E + L L Sbjct: 289 NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA----RRLGSLP 344 Query: 643 CLKLW-YNHIAYIPIQIG--NLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLT 698 CL L +H A +++G L +L L L N + +P F L+ L+L N ++ Sbjct: 345 CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 404 Query: 699 FL-----PADIGL-----LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNN-VLQSLP 747 P G + +L++L++ N IE L F L L L +N L+ Sbjct: 405 PCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVAT 464 Query: 748 SRVGEL-TNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLP 795 +G L +L + L+GN L L V+L LKR L + E+ S LP Sbjct: 465 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKR--LNLAENRLSHLP 511 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 88/198 (44%), Gaps = 18/198 (9%) Query: 587 LKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646 L + L L+L LE + +L +L+ + L+ N L+ + +F +L L L L Sbjct: 340 LGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPY-TFANLASLQRLNL 398 Query: 647 WYNHIAYIP----------IQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN- 695 N ++ + +T+L L L N+IE + F L LDLS N Sbjct: 399 QGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNP 458 Query: 696 NLTFLPADIGLLQ-NLQNLAVTANRIEALPPEL--FQCRKLRALHLGNNVLQSLPSRVGE 752 L +G L+ +L+ LA+ N + L +L F C L+ L+L N L LP+ + Sbjct: 459 GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC--LKRLNLAENRLSHLPAWT-Q 515 Query: 753 LTNLTQIELRGNRLECLP 770 +L ++LR N LP Sbjct: 516 AVSLEVLDLRNNSFSLLP 533 >3J0A-A nrPDB Length = 844 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 73/272 (26%), Positives = 118/272 (43%), Gaps = 31/272 (11%) Query: 543 LKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLI---VLNSLKKMVNLTELELI 599 LK LKVL L N K+ ++ + L L + N L+ ++ + + ++L Sbjct: 289 LKDLKVLNLAYN--KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQ 346 Query: 600 RCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658 + + I F L LQ +DL+DN L TI I S + L N + +P +I Sbjct: 347 KNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF------LSGNKLVTLP-KI 399 Query: 659 GNLTNLERLYLNRNKIEKIPTQLFYCR--KLRYLDLSHNNLTFLPADIGLLQN--LQNLA 714 NL ++L+ N++E + F R L+ L L+ N + D +N L+ L Sbjct: 400 NLTANL--IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLF 457 Query: 715 VTANRIE-----ALPPELFQ-CRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNRLE 767 + N ++ L ++F+ L+ L+L +N L SLP V LT L + L NRL Sbjct: 458 LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 517 Query: 768 C-----LPVELGECPLLKRSGLVVEEDLFSTL 794 LP L + + L D+F +L Sbjct: 518 VLSHNDLPANLEILDISRNQLLAPNPDVFVSL 549 >3CIG-A nrPDB Length = 697 Score = 38.1 bits (87), Expect = 0.016, Method: Compositional matrix adjust. Identities = 52/160 (32%), Positives = 74/160 (46%), Gaps = 8/160 (5%) Query: 592 NLTELELIRCDLERIPHSIFSLHN-LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 N+T L L L R+P + F+ ++ L +D N++ +E + Q L L L L +N Sbjct: 26 NITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELC-QILPLLKVLNLQHNE 84 Query: 651 IAYIPIQIGNL-TNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLLQ 708 ++ I Q TNL L L N I KI + F +K L LDLSHN L+ G+ Sbjct: 85 LSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQL 144 Query: 709 NLQNLAVTA-NRIEALPP---ELFQCRKLRALHLGNNVLQ 744 + A N+I AL E LR L L +N L+ Sbjct: 145 ENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLK 184 Score = 30.0 bits (66), Expect = 4.4, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 13/102 (12%) Query: 593 LTELELIRCDLERI---PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN 649 L L L R L+ + P L NL +DL +NN+ I E + + L L L +N Sbjct: 456 LQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDL-LEGLENLEILDFQHN 514 Query: 650 HIAYI--------PIQ-IGNLTNLERLYLNRNKIEKIPTQLF 682 ++A + P+ + L++L L L N +++IP +F Sbjct: 515 NLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVF 556 >3CVR-A nrPDB Length = 571 Score = 38.1 bits (87), Expect = 0.017, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 82/191 (42%), Gaps = 54/191 (28%) Query: 593 LTELELIRCDLERIP--------------HSIFSL----HNLQEIDLKDNNLKTIEEI-I 633 +EL+L R +L +P +++ SL +L+ +D DN L T+ E+ Sbjct: 61 FSELQLNRLNLSSLPDNLPPQITVLEITQNALISLPELPASLEYLDACDNRLSTLPELPA 120 Query: 634 SFQHL----HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRY 689 S +HL ++LT L + YI LT L L PT L Sbjct: 121 SLKHLDVDNNQLTMLPELPALLEYINADNNQLTMLPEL----------PT------SLEV 164 Query: 690 LDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPE------------LFQCRKLRALH 737 L + +N LTFLP L ++L+ L V+ N +E+LP F+CR+ R H Sbjct: 165 LSVRNNQLTFLPE---LPESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRITH 221 Query: 738 LGNNVLQSLPS 748 + N+L P+ Sbjct: 222 IPENILSLDPT 232 >2FT3-A nrPDB Length = 332 Score = 37.4 bits (85), Expect = 0.025, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 88/203 (43%), Gaps = 9/203 (4%) Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627 HL L + N I + + L +L + + L IP ++ S +L E+ + DN ++ Sbjct: 79 HLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDNRIR 136 Query: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL--NRNKIEKIPTQLFYCR 685 + + + F L + C+++ N + + G L+ YL + K+ IP L Sbjct: 137 KVPKGV-FSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDL--PE 193 Query: 686 KLRYLDLSHNNLTFLP-ADIGLLQNLQNLAVTANRIEALP-PELFQCRKLRALHLGNNVL 743 L L L HN + + D+ L L + N+I + L LR LHL NN L Sbjct: 194 TLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKL 253 Query: 744 QSLPSRVGELTNLTQIELRGNRL 766 +P+ + +L L + L N + Sbjct: 254 SRVPAGLPDLKLLQVVYLHTNNI 276 Score = 35.4 bits (80), Expect = 0.098, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 83/182 (45%), Gaps = 26/182 (14%) Query: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE--E 631 + N G + + LK L L + L IP + L E+ L N ++ IE + Sbjct: 159 LENSGFEPGAFDGLK----LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIELED 212 Query: 632 IISFQHLHRLTCLKLWYNHIAYIPIQIGNLT---NLERLYLNRNKIEKIPTQLFYCRKLR 688 ++ + L+RL L +N I I + G+L+ L L+L+ NK+ ++P L + L+ Sbjct: 213 LLRYSKLYRLG---LGHNQIRMI--ENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQ 267 Query: 689 YLDLSHNNLT------FLPADIGLLQNLQN-LAVTANRIE--ALPPELFQCRKLR-ALHL 738 + L NN+T F P G+ + N +++ N + + P F+C R A+ Sbjct: 268 VVYLHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQF 327 Query: 739 GN 740 GN Sbjct: 328 GN 329 Score = 28.9 bits (63), Expect = 9.2, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 68/160 (42%), Gaps = 22/160 (13%) Query: 491 LRENLRALHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRY--IVIDGLR-ELKRL 546 L +L L I I+++P ++S L+ + + + GN EN+ + DGL+ R+ Sbjct: 121 LPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGN-PLENSGFEPGAFDGLKLNYLRI 179 Query: 547 KVLRLKSNLSKLPQVVTDVGV-----------------HLQKLSINNEGTKLIVLNSLKK 589 +L LP+ + ++ + L +L + + ++I SL Sbjct: 180 SEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSF 239 Query: 590 MVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629 + L EL L L R+P + L LQ + L NN+ + Sbjct: 240 LPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKV 279 >3A7C-A nrPDB Length = 580 Score = 37.0 bits (84), Expect = 0.035, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 62/137 (45%), Gaps = 28/137 (20%) Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL----TFLPADIGLLQ-------- 708 L NL L ++RN +P + K+R+L+LS + T +P + +L Sbjct: 412 LKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDS 471 Query: 709 ------NLQNLAVTANRIEALP-PELFQCRKLRALHLGNNVLQSLPSRV-GELTNLTQIE 760 LQ L ++ N+++ LP LF L + + +N L+S+P + LT+L +I Sbjct: 472 FSLFLPRLQELYISRNKLKTLPDASLFPV--LLVMKIASNQLKSVPDGIFDRLTSLQKIW 529 Query: 761 LRGNRLECLPVELGECP 777 L N +C CP Sbjct: 530 LHTNPWDC------SCP 540 >3A79-B nrPDB Length = 562 Score = 36.2 bits (82), Expect = 0.053, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 16/122 (13%) Query: 659 GNLTNLERLYLNRNKIE---KIPTQLFYCRKLRYLDLSHNNL-------TFLPADIGLLQ 708 L L+ L L RN ++ K+ L LD+S N+L T A+ L+ Sbjct: 374 STLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVL 433 Query: 709 NLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 NL + +T + LPP K++ L L NN + S+P V L L ++ + N+L+ Sbjct: 434 NLSSNMLTGSVFRCLPP------KVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKS 487 Query: 769 LP 770 +P Sbjct: 488 VP 489 Score = 36.2 bits (82), Expect = 0.055, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 29/43 (67%) Query: 686 KLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELF 728 K++ LDL +N + +P D+ LQ LQ L V +N+++++P +F Sbjct: 451 KVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPDGVF 493 Score = 33.1 bits (74), Expect = 0.51, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 29/162 (17%) Query: 654 IPIQIGNLTNLERLYLNRNKIEK--IPTQLFYCRKLRYLDLSHNNLT-----FLPADIGL 706 + + N+++LE L ++ N + + + L+LS N LT LP + + Sbjct: 395 VALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKV 454 Query: 707 LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNR 765 L +L N NRI ++P ++ + L+ L++ +N L+S+P V LT+L I L N Sbjct: 455 L-DLHN-----NRIMSIPKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNP 508 Query: 766 LECLPVELGECPLL--------KRSGLVVEEDLFSTLPPEVK 799 +C CP + K SG VV S P K Sbjct: 509 WDC------TCPGIRYLSEWINKHSG-VVRNSAGSVAPDSAK 543 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 10/90 (11%) Query: 640 RLTCLKLWYNHIAYIPI-QIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHN-- 695 R L L N I+ + + I L+ L L L+ N+I + +F + + L YLD+SHN Sbjct: 53 RTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRL 112 Query: 696 -NLTFLPADIGLLQNLQNLAVTANRIEALP 724 N++ P + +L++L ++ N + LP Sbjct: 113 QNISCCP-----MASLRHLDLSFNDFDVLP 137 >5Y3M-A nrPDB Length = 801 Score = 35.8 bits (81), Expect = 0.082, Method: Compositional matrix adjust. Identities = 56/190 (29%), Positives = 83/190 (43%), Gaps = 43/190 (22%) Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI--AYIPIQIGNLTNLERLYLNRNKIE- 675 +DL NNL TI++ + F L RL CL+L +N I A Q LT+L L L+ NK++ Sbjct: 455 LDLSRNNLVTIQQEM-FTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDL 513 Query: 676 -------KIP----------TQLFYCR-------------KLRYLDLSHNNLTFLPADIG 705 ++P +Q F + LRYL L+HN + + Sbjct: 514 YHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKL 573 Query: 706 LLQNLQNLAVTANRIEALPPE--LFQC-----RKLRALHLGNNVLQS-LPSRVGEL-TNL 756 +L+ L + N + + E L+ C R L L L N L + LP + L +L Sbjct: 574 SSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSL 633 Query: 757 TQIELRGNRL 766 Q+ LR N L Sbjct: 634 RQLRLRDNNL 643 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 48/167 (28%), Positives = 71/167 (42%), Gaps = 38/167 (22%) Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL-TNLERLYLN 670 L NL ++DL +N HLH L +P + NL +L +L L Sbjct: 604 GLRNLVQLDLSEN------------HLHTL------------LPRHLDNLPKSLRQLRLR 639 Query: 671 RNKIEKIP-TQLFYCRKLRYLDLSHNNLTF-----LPADIGLLQNLQNLAVTANRIEALP 724 N + + L +L LDL+ N L LP I LQ L V++N I + Sbjct: 640 DNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGI----RLQKLDVSSNSIGFVI 695 Query: 725 PELF-QCRKLRALHLGNNVLQSL-PSRVGELTNLTQI-ELRGNRLEC 768 P F + +L L+L N L+++ PS G L +I ++ N L C Sbjct: 696 PGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHC 742 >2V9T-B nrPDB Length = 220 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 24/68 (35%), Positives = 39/68 (57%), Gaps = 2/68 (2%) Query: 664 LERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPAD-IGLLQNLQNLAVTANRIE 721 + + L +N I+ IP F +KLR +DLS+N ++ L D L++L +L + N+I Sbjct: 34 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 93 Query: 722 ALPPELFQ 729 LP LF+ Sbjct: 94 ELPKSLFE 101 >5Y3K-A nrPDB Length = 802 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 56/190 (29%), Positives = 81/190 (42%), Gaps = 43/190 (22%) Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI--AYIPIQIGNLTNLERLYLNRNKIE- 675 +DL NNL T++ + F L RL CL+L +N I A Q LT+L+ L L+ NK++ Sbjct: 456 LDLSRNNLVTVQPEM-FAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDL 514 Query: 676 -------KIP----------TQLFYCRK-------------LRYLDLSHNNLTFLPADIG 705 ++P +Q F R LRYL L+HN + + Sbjct: 515 YHGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQL 574 Query: 706 LLQNLQNLAVTANRIEALPPE------LFQC-RKLRALHLGNNVLQS-LPSRVGELT-NL 756 +L L + N + + E FQ R L L L N L + LP +G L +L Sbjct: 575 CSTSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSL 634 Query: 757 TQIELRGNRL 766 + LR N L Sbjct: 635 QLLRLRNNYL 644 >4AY9-X nrPDB Length = 350 Score = 34.3 bits (77), Expect = 0.23, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 96/203 (47%), Gaps = 44/203 (21%) Query: 553 SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS 612 SNL KL ++ + +L L IN E + + + NL L + ++ +P + Sbjct: 76 SNLPKLHEIRIEKANNL--LYINPE--------AFQNLPNLQYLLISNTGIKHLP-DVHK 124 Query: 613 LHNLQEI--DLKDN-NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669 +H+LQ++ D++DN N+ TIE R + + L + + L+L Sbjct: 125 IHSLQKVLLDIQDNINIHTIE---------RNSFVGLSFESVI--------------LWL 161 Query: 670 NRNKIEKIPTQLFYCRKLRYLDLS-HNNLTFLPADI--GLLQNLQNLAVTANRIEALPP- 725 N+N I++I F +L L+LS +NNL LP D+ G + L ++ RI +LP Sbjct: 162 NKNGIQEIHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVI-LDISRTRIHSLPSY 220 Query: 726 ELFQCRKLRALHLGNNVLQSLPS 748 L +KLRA N L+ LP+ Sbjct: 221 GLENLKKLRARSTYN--LKKLPT 241 >5D3I-A nrPDB Length = 568 Score = 33.9 bits (76), Expect = 0.33, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 5/87 (5%) Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 L NL L ++RN +P + K+R+L+LS + + I Q L+ L V+ N + Sbjct: 390 LKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIP--QTLEVLDVSNNNL 447 Query: 721 EALPPELFQCRKLRALHLGNNVLQSLP 747 ++ LF R L+ L++ N L++LP Sbjct: 448 DSF--SLFLPR-LQELYISRNKLKTLP 471 >5GY2-A nrPDB Length = 455 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 3/72 (4%) Query: 586 SLKKMVNLTELELIRCDLER--IPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 + + NL L L +C+L+ + + F L +L+ + L+DNN+K I+ F ++ R Sbjct: 98 AFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFH 157 Query: 643 CLKLWYNHIAYI 654 L L +N + I Sbjct: 158 VLDLTFNKVKSI 169 >3V44-A nrPDB Length = 407 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 3/72 (4%) Query: 586 SLKKMVNLTELELIRCDLER--IPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 + + NL L L +C+L+ + + F L +L+ + L+DNN+K I+ F ++ R Sbjct: 98 AFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFH 157 Query: 643 CLKLWYNHIAYI 654 L L +N + I Sbjct: 158 VLDLTFNKVKSI 169 >1XWD-C nrPDB Length = 252 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 94/204 (46%), Gaps = 46/204 (22%) Query: 553 SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS 612 SNL KL ++ + +L L IN E + + + NL L + ++ +P + Sbjct: 76 SNLPKLHEIRIEKANNL--LYINPE--------AFQNLPNLQYLLISNTGIKHLP-DVHK 124 Query: 613 LHNLQEI--DLKDN-NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669 +H+LQ++ D++DN N+ TIE R + + L + + L+L Sbjct: 125 IHSLQKVLLDIQDNINIHTIE---------RNSFVGLSFESVI--------------LWL 161 Query: 670 NRNKIEKIPTQLFYCRKLRYLDLS-HNNLTFLPADIGLLQNLQN---LAVTANRIEALPP 725 N+N I++I F +L L+LS +NNL LP D+ L ++ RI +LP Sbjct: 162 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDV--FHGASGPVILDISRTRIHSLPS 219 Query: 726 -ELFQCRKLRALHLGNNVLQSLPS 748 L +KLRA N L+ LP+ Sbjct: 220 YGLENLKKLRARSTYN--LKKLPT 241 >5KH1-A nrPDB Length = 591 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 75/311 (24%), Positives = 122/311 (39%), Gaps = 59/311 (18%) Query: 385 LYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLR--------QRLT---KNAQDKLELHLF 433 L S F+ + + S L EW ++++ QRL +N + L+L Sbjct: 18 LISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNLDLSEL 77 Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493 L+ +P+ + + + K L +P S+ QL IE PAL + Sbjct: 78 GLTTLPEIPPGIKSINISKNNLSLISPLPASLTQLN-------VSYNRLIELPALPQGLK 130 Query: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553 L A H + + +P+ +L+ELH++ NN+ + L EL L+ L + Sbjct: 131 LLNASHNQLITLPTLPI------SLKELHVS------NNQLCSLPVLPEL--LETLDVSC 176 Query: 554 N-LSKLP------QVVTDVGVHLQKL-----------SINNEGTKLIVLNSLKKMVNLTE 595 N L+ LP Q ++ +G L +L +I+N T + L NL Sbjct: 177 NGLAVLPPLPFSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPE-----NLRN 231 Query: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP 655 + IP SI +L N ID+ DN L + + Q L RLT ++ Y Sbjct: 232 GYFDINQISHIPESILNLRNECSIDISDNPLSS----HALQSLQRLTSSPDYHGPQIYFS 287 Query: 656 IQIGNLTNLER 666 + G L R Sbjct: 288 MSDGQQNTLHR 298 Score = 29.6 bits (65), Expect = 6.1, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 25/180 (13%) Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT----NLERLYLNRNKIEKI 677 K+N ++ + I+FQ L ++CL+ ++ + + L ++ + +++N + I Sbjct: 45 KNNRIQEEQRDIAFQRL--VSCLQNQETNLDLSELGLTTLPEIPPGIKSINISKNNLSLI 102 Query: 678 PTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALH 737 L L++S+N L LPA L Q L+ L + N++ LP L+ LH Sbjct: 103 SP---LPASLTQLNVSYNRLIELPA---LPQGLKLLNASHNQLITLPTLPI---SLKELH 153 Query: 738 LGNNVLQSLPSRVGELTNLTQIELRG-NRLECLPVELGECPLLKRSGLVVEEDLFSTLPP 796 + NN L SLP + EL + G L LP L E + +L S LPP Sbjct: 154 VSNNQLCSLPV-LPELLETLDVSCNGLAVLPPLPFSLQEISAIG--------NLLSELPP 204 >2Z80-A nrPDB Length = 353 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 96/252 (38%), Gaps = 50/252 (19%) Query: 567 VHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNN 625 V+LQ L + + G I +S + +L L+L L + S F L +L ++L N Sbjct: 76 VNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135 Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ---IGNLTNLERLYLNRNKIEKIP---- 678 KT+ E F HL +L L++ N + IQ LT LE L ++ + ++ Sbjct: 136 YKTLGETSLFSHLTKLQILRV-GNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSL 194 Query: 679 --------------------------TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL-- 710 T C +LR DL + F G +L Sbjct: 195 KSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDL--DTFHFSELSTGETNSLIK 252 Query: 711 ----QNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNR 765 +N+ +T + + L Q L L N L+S+P + LT+L +I L N Sbjct: 253 KFTFRNVKITDESLFQVMKLLNQISGLLELEFSRNQLKSVPDGIFDRLTSLQKIWLHTNP 312 Query: 766 LECLPVELGECP 777 +C CP Sbjct: 313 WDC------SCP 318 >3G04-C nrPDB Length = 239 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 72/172 (41%), Gaps = 23/172 (13%) Query: 553 SNLSKLPQVVTDVGVHLQKLSI---------------NNEGTKLIVLNSLKKMVNLTELE 597 SNL + ++ + V LQ+L N I ++LK++ L L Sbjct: 52 SNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLG 111 Query: 598 LIRCDLERIPH--SIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT-CLKLWYNHIAYI 654 + L+ P ++S +++ DN T + +FQ L T LKL+ N + Sbjct: 112 IFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSV 171 Query: 655 PIQIGNLTNLERLYLNRNK----IEKIPTQLFYCRKLRYLDLSHNNLTFLPA 702 N T L+ +YLN+NK I+K Y LD+S ++T LP+ Sbjct: 172 QGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGP-SLLDVSQTSVTALPS 222 >2Z7X-A nrPDB Length = 549 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 5/113 (4%) Query: 567 VHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNN 625 V+LQ L + + G I +S + +L L+L L + S F L +L ++L N Sbjct: 50 VNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 109 Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ---IGNLTNLERLYLNRNKIE 675 KT+ E F HL +L L++ N + IQ LT LE L ++ + ++ Sbjct: 110 YKTLGETSLFSHLTKLQILRVG-NMDTFTKIQRKDFAGLTFLEELEIDASDLQ 161 >3TSR-E nrPDB Length = 457 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 70/160 (43%), Gaps = 16/160 (10%) Query: 483 IEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRE 542 ++ P + +L+ + +P + SL TL ELHL N + ++ +GL++ Sbjct: 76 LQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQD 135 Query: 543 LK-RLKVLRLK-SNLSKLP----QVVTDVGVHLQKLSINNE-----GTKLIVLNSLKKMV 591 + RL+ L+L+ NL+ V V ++L ++N G +++ Sbjct: 136 PQCRLEKLQLEYCNLTATSCEPLASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSAC 195 Query: 592 NLTELELIRCDL-----ERIPHSIFSLHNLQEIDLKDNNL 626 L L+L C + + + + S +LQE+DL N L Sbjct: 196 QLESLKLENCGITAANCKDLCDVVASKASLQELDLSSNKL 235 >3OT5-A nrPDB Length = 403 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 33/151 (21%), Positives = 62/151 (41%), Gaps = 12/151 (7%) Query: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179 A ++ +L H L N + FP ++ ++ SP T +A + E Sbjct: 131 GLATFYQQKMLGHVEAGLRTWNKYSPFPEEMNR--QLTGVMADIHFSP-TKQAKENLLAE 187 Query: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQR-TKSRIEQGIVDRSETGVLDKKEGE 238 DP F N ++D +TV +D P+L+ +R+ R E GE Sbjct: 188 GKDPATIFVTGNTAIDALKTTVQKDYHH--PILENLGDNRLILMTAHRREN------LGE 239 Query: 239 QAKALFEKVKKFRTHVEEGDIVYRLYMRQTI 269 + +FE V++ E+ ++VY +++ + Sbjct: 240 PMQGMFEAVREIVESREDTELVYPMHLNPAV 270 >5YXM-A nrPDB Length = 203 Score = 30.4 bits (67), Expect = 2.9, Method: Compositional matrix adjust. Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 8/81 (9%) Query: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLW--YNHIAY 653 L L ++E+I S+ + NL+ + L N +K IE + + T +LW YN IA Sbjct: 58 LALSTNNIEKI-SSLSGMENLRILSLGRNLIKKIENLDAVAD----TLEELWISYNQIAS 112 Query: 654 IPIQIGNLTNLERLYLNRNKI 674 + I L NL LY++ NKI Sbjct: 113 LS-GIEKLVNLRVLYMSNNKI 132 >1DCE-A nrPDB Length = 567 Score = 30.4 bits (67), Expect = 3.0, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 1/56 (1%) Query: 689 YLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQ 744 +LDLSHN L LP + L+ L+ L + N +E + + +L+ L L NN LQ Sbjct: 467 HLDLSHNRLRALPPALAALRCLEVLQASDNALENVDG-VANLPRLQELLLCNNRLQ 521 >1M9S-A nrPDB Length = 605 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 26/63 (41%), Positives = 32/63 (50%), Gaps = 2/63 (3%) Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 L LE LYL NKI I T L KL L L N ++ + GL + LQNL ++ N I Sbjct: 130 LPQLESLYLGNNKITDI-TVLSRLTKLDTLSLEDNQISDIVPLAGLTK-LQNLYLSKNHI 187 Query: 721 EAL 723 L Sbjct: 188 SDL 190 >1JL5-A nrPDB Length = 454 Score = 29.3 bits (64), Expect = 8.0, Method: Compositional matrix adjust. Identities = 70/278 (25%), Positives = 116/278 (41%), Gaps = 60/278 (21%) Query: 539 GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL 598 G E + + V RL+ L + +L +NN G L+SL ++ E + Sbjct: 53 GNGEQREMAVSRLRDCLDR----------QAHELELNNLG-----LSSLPELPPHLESLV 97 Query: 599 IRC----DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI 654 C +L +P S+ SL + +NNLK + ++ L L + N + + Sbjct: 98 ASCNSLTELPELPQSLKSLL------VDNNNLKALSDLPPL-----LEYLGVSNNQLEKL 146 Query: 655 PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP------------A 702 P ++ N + L+ + ++ N ++K+P L ++ +N L LP A Sbjct: 147 P-ELQNSSFLKIIDVDNNSLKKLPD---LPPSLEFIAAGNNQLEELPELQNLPFLTAIYA 202 Query: 703 DIGLLQNLQNLA------VTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756 D L+ L +L V N I PEL L ++ NN+L++LP L L Sbjct: 203 DNNSLKKLPDLPLSLESIVAGNNILEELPELQNLPFLTTIYADNNLLKTLPDLPPSLEAL 262 Query: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTL 794 +R N L LP EL + + L V E++FS L Sbjct: 263 N---VRDNYLTDLP-ELPQS----LTFLDVSENIFSGL 292 >3WPI-A nrPDB Length = 803 Score = 28.9 bits (63), Expect = 8.7, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 34/79 (43%), Gaps = 22/79 (27%) Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP 678 +DL NNL TI+ + F L RL CL L +N IA Q N Sbjct: 457 MDLSRNNLVTIKPEM-FVQLSRLQCLSLSHNSIA----QAVN-----------------G 494 Query: 679 TQLFYCRKLRYLDLSHNNL 697 +Q L+ LDLSHN L Sbjct: 495 SQFLPLTNLQVLDLSHNKL 513 >2BNH-A nrPDB Length = 457 Score = 28.9 bits (63), Expect = 9.1, Method: Compositional matrix adjust. Identities = 35/160 (21%), Positives = 70/160 (43%), Gaps = 16/160 (10%) Query: 483 IEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRE 542 +++P + +L+ + +P + SL TL ELHL+ N + ++ +GL + Sbjct: 76 LQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEGLLD 135 Query: 543 ----LKRLKV--LRLKSNLSKLPQVVTDVGVHLQKLSINNE-----GTKLIVLNSLKKMV 591 L++L++ RL + + V L++L+++N G +++ Sbjct: 136 PQCHLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSAC 195 Query: 592 NLTELELIRCDL-----ERIPHSIFSLHNLQEIDLKDNNL 626 L L L C L + + + S +L+E+DL N L Sbjct: 196 QLETLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGL 235 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6O00-A nrPDB 1389 0.0 5XJX-C nrPDB 213 3e-55 6HLU-A nrPDB 211 8e-55 1XCD-A nrPDB 200 2e-51 5YQ5-A nrPDB 185 5e-47 4R6F-A nrPDB 179 4e-45 5MX0-A nrPDB 174 2e-43 4ECN-A nrPDB 172 4e-43 5ZSN-B nrPDB 162 6e-40 6HKW-A nrPDB 156 3e-38 5LFN-A nrPDB 149 3e-36 4R08-A nrPDB 148 1e-35 4QDH-A nrPDB 141 1e-33 3RG1-A nrPDB 137 3e-32 1OGQ-A nrPDB 136 3e-32 3B2D-A nrPDB 136 3e-32 3T6Q-A nrPDB 133 3e-31 4PUF-A nrPDB 132 7e-31 3G06-A nrPDB 123 3e-28 5Y31-B nrPDB 100 2e-21 3ULU-A nrPDB 100 3e-21 2XOT-A nrPDB 99 7e-21 2Z7X-B nrPDB 99 1e-20 Sequences not found previously or not previously below threshold: 3WPI-A nrPDB 138 9e-33 5Y3M-A nrPDB 131 9e-31 6GFF-I nrPDB 123 3e-28 2FT3-A nrPDB 117 2e-26 3CIG-A nrPDB 117 2e-26 5Y3K-A nrPDB 115 1e-25 3J0A-A nrPDB 103 4e-22 3A7C-A nrPDB 102 6e-22 1JL5-A nrPDB 102 6e-22 5GY2-A nrPDB 91 2e-18 5D3I-A nrPDB 90 4e-18 3V44-A nrPDB 89 8e-18 3A79-B nrPDB 89 1e-17 2Z7X-A nrPDB 84 3e-16 2Z80-A nrPDB 81 2e-15 3CVR-A nrPDB 80 4e-15 1M9S-A nrPDB 75 1e-13 5KH1-A nrPDB 74 3e-13 2V9T-B nrPDB 74 3e-13 4AY9-X nrPDB 71 2e-12 1XWD-C nrPDB 68 2e-11 5YXM-A nrPDB 62 1e-09 3TSR-E nrPDB 60 5e-09 2BNH-A nrPDB 57 2e-08 3G04-C nrPDB 55 9e-08 1DCE-A nrPDB 54 2e-07 4PEQ-B nrPDB 52 7e-07 2IFG-A nrPDB 49 6e-06 4PBW-B nrPDB 48 1e-05 6ICZ-o nrPDB 47 3e-05 5LJ5-W nrPDB 45 8e-05 4PBV-A nrPDB 45 9e-05 2Q4G-W nrPDB 44 2e-04 3JB9-j nrPDB 44 3e-04 6J5T-G nrPDB 44 4e-04 4WYK-A nrPDB 39 0.009 1KOH-A nrPDB 39 0.011 4K17-A nrPDB 38 0.014 2P1O-B nrPDB 37 0.026 1PU7-A nrPDB 34 0.30 4NUY-A nrPDB 34 0.32 3OT5-A nrPDB 33 0.59 3DIN-A nrPDB 30 3.2 2FJI-1 nrPDB 30 6.0 5YFP-C nrPDB 29 6.4 1GVH-A nrPDB 29 7.1 6MDV-A nrPDB 29 7.6 1LNS-A nrPDB 29 8.6 5A08-A nrPDB 29 8.9 >6O00-A nrPDB Length = 820 Score = 1389 bits (3595), Expect = 0.0, Method: Composition-based stats. Identities = 810/810 (100%), Positives = 810/810 (100%) Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60 Query: 61 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW Sbjct: 61 TKDSCNDSFRGWAASSPEPTYPNSTVLPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120 Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE Sbjct: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180 Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA Sbjct: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240 Query: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE 300 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE Sbjct: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIE 300 Query: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES Sbjct: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360 Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL Sbjct: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420 Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA Sbjct: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480 Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL Sbjct: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540 Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR Sbjct: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600 Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 Query: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK Sbjct: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780 Query: 781 RSGLVVEEDLFSTLPPEVKERLWRADKEQA 810 RSGLVVEEDLFSTLPPEVKERLWRADKEQA Sbjct: 781 RSGLVVEEDLFSTLPPEVKERLWRADKEQA 810 >5XJX-C nrPDB Length = 433 Score = 213 bits (542), Expect = 3e-55, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 132/294 (44%), Gaps = 18/294 (6%) Query: 528 SAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVT----DVGVHLQKLSINNEGTKLIV 583 + + R V + L LK LK L L + PQ + +G LQ L + G + Sbjct: 89 TCDPQRSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPI 148 Query: 584 LNSLKKMVNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 + L + NL L+L + L IP S L+ +DL N L I F L L+ Sbjct: 149 PDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLT--GSIPGFV-LPALS 205 Query: 643 CLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIEK-IPTQLFYCRKLRYLDLSHNNLTF- 699 L L N + +P + + +L ++ L+RN++ IP + +L LDLS+N L+ Sbjct: 206 VLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGP 265 Query: 700 LPADIGLLQNLQNLAVTANR--IEALPPELFQC-RKLRALHLGN-NVLQSLPSRVGELTN 755 P+ + L +LQ L + N +P F+ + L L L N N+ S+P + L + Sbjct: 266 FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNS 325 Query: 756 LTQIELRGNRLEC-LPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRADKE 808 L + L GN L +P+E + S L + ++ + P ++ +WR ++ Sbjct: 326 LRVLHLEGNNLTGEIPLEFRDVK--HLSELRLNDNSLTGPVPFERDTVWRMRRK 377 Score = 83.2 bits (204), Expect = 4e-16, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 84/240 (35%), Gaps = 26/240 (10%) Query: 435 LSGIPDTVFDLVELEVLKLELIPD-VTIPPSIAQLTGLKELWLYHTAAKIEAPAL----- 488 L IPD + +L L+VL L +IP S + +GL+ L L P Sbjct: 145 LGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPAL 204 Query: 489 -----------AFLRE------NLRALHIKFTDIK-EIPLWIYSLKTLEELHLTGNLSAE 530 + +L + + + IP I L L L L+ Sbjct: 205 SVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLS-YNRLS 263 Query: 531 NNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKM 590 + GL L+ L + + +P+ +L L ++N + + SL ++ Sbjct: 264 GPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRL 323 Query: 591 VNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN 649 +L L L +L IP + +L E+ L DN+L L+L+ N Sbjct: 324 NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRRKLRLYNN 383 >6HLU-A nrPDB Length = 974 Score = 211 bits (538), Expect = 8e-55, Method: Composition-based stats. Identities = 98/364 (26%), Positives = 162/364 (44%), Gaps = 29/364 (7%) Query: 445 LVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTD 504 L L +L L+ I P +A L L LWL+ AP + ++L L + Sbjct: 112 LNSLSMLWLDRNQITDIAP-LASLNSLSMLWLFGNKISDIAPLESL--KSLTELQLSSNQ 168 Query: 505 IKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTD 564 I +I + SLK+L EL L+GN ++ I L LK L L L SN + Sbjct: 169 ITDIA-PLASLKSLTELSLSGNNISD------IAPLESLKSLTELSLSSNQITDIAPLAS 221 Query: 565 VGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDN 624 + L +LS+++ I L+ + +LTEL+L R + I + SL +L E+ L N Sbjct: 222 LK-SLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDI-APLESLKSLTELQLSSN 277 Query: 625 NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYC 684 + I + S L LT L+L N I+ I + +L +L +L+LN N+I I L Sbjct: 278 QITDIAPLAS---LKSLTELQLSRNQISDIAP-LESLNSLSKLWLNGNQITDI-APLASL 332 Query: 685 RKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQ 744 L L+LS N +T + A + L++L L +++N+I + P N + Sbjct: 333 NSLTELELSSNQITDI-APLASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISD 391 Query: 745 SLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVE-------EDLFSTLPPE 797 P + L +LT ++R N ++ LP + + ++ + PPE Sbjct: 392 ISP--LASLNSLTGFDVRRNPIKRLPETITGFDMEILWNDFSSSGFITFFDNPLESPPPE 449 Query: 798 VKER 801 + ++ Sbjct: 450 IVKQ 453 Score = 142 bits (358), Expect = 5e-34, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 117/284 (41%), Gaps = 35/284 (12%) Query: 503 TDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVV 562 I +I + SL +L L L + N+ I L L L +L L N + Sbjct: 101 NQITDIS-PLASLNSLSMLWL------DRNQITDIAPLASLNSLSMLWLFGNKISDIAPL 153 Query: 563 TDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLK 622 + L +L +++ I L + +LTEL L ++ I + SL +L E+ L Sbjct: 154 ESLK-SLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDI-APLESLKSLTELSLS 209 Query: 623 DNNLKTIEEIISFQ-------------------HLHRLTCLKLWYNHIAYIPIQIGNLTN 663 N + I + S + L LT L+L N I+ I + +L + Sbjct: 210 SNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQISDIAP-LESLKS 268 Query: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEAL 723 L L L+ N+I I L + L L LS N ++ + A + L +L L + N+I + Sbjct: 269 LTELQLSSNQITDI-APLASLKSLTELQLSRNQISDI-APLESLNSLSKLWLNGNQITDI 326 Query: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767 P L L L +N + + + + L +L+ + L N++ Sbjct: 327 APLASL-NSLTELELSSNQITDI-APLASLKSLSTLWLSSNQIS 368 Score = 94.8 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 58/227 (25%), Positives = 107/227 (47%), Gaps = 8/227 (3%) Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600 L + S+L + Q+ ++G+ L+ + +K L+ +++ + + Sbjct: 18 ENLYFQGAMGSMSDLDVIRQIEQELGMQLEPVDKLKWYSKGYKLDKDQRVTAIGLYDCGS 77 Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660 L+RI + SL +L E+ L N + I + S L+ L+ L L N I I + + Sbjct: 78 DTLDRIIQPLESLKSLSELSLSSNQITDISPLAS---LNSLSMLWLDRNQITDIAP-LAS 133 Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 L +L L+L NKI I L + L L LS N +T + A + L++L L+++ N I Sbjct: 134 LNSLSMLWLFGNKISDI-APLESLKSLTELQLSSNQITDI-APLASLKSLTELSLSGNNI 191 Query: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767 + P L + L L L +N + + + + L +LT++ L N++ Sbjct: 192 SDIAP-LESLKSLTELSLSSNQITDI-APLASLKSLTELSLSSNQIS 236 >1XCD-A nrPDB Length = 329 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 76/314 (24%), Positives = 138/314 (43%), Gaps = 49/314 (15%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA-KIEAPALAFLRENLRA 497 PDT L++L+ K+ I D L L L L + KI A A L + L Sbjct: 52 PDTA--LLDLQNNKITEIKDG----DFKNLKNLHTLILINNKISKISPGAFAPLVK-LER 104 Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 L++ +KE+P + KTL+EL + N R V +GL ++ Sbjct: 105 LYLSKNQLKELPEKMP--KTLQELRVHEN-EITKVRKSVFNGLNQM-------------- 147 Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQ 617 +V ++G + K S G + + M L+ + + ++ IP + +L Sbjct: 148 ---IVVELGTNPLKSSGIENG-------AFQGMKKLSYIRIADTNITTIPQGLP--PSLT 195 Query: 618 EIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI-QIGNLTNLERLYLNRNKIEK 676 E+ L N + ++ S + L+ L L L +N I+ + + N +L L+LN NK+ K Sbjct: 196 ELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK 254 Query: 677 IPTQLFYCRKLRYLDLSHNNLT------FLPADIGLLQ-NLQNLAVTANRIE--ALPPEL 727 +P L + ++ + L +NN++ F P + + +++ +N ++ + P Sbjct: 255 VPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPST 314 Query: 728 FQCRKLR-ALHLGN 740 F+C +R A+ LGN Sbjct: 315 FRCVYVRAAVQLGN 328 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 54/237 (22%), Positives = 99/237 (41%), Gaps = 11/237 (4%) Query: 548 VLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERI 606 +L L++N ++++ +L L + N I + +V L L L + L+ + Sbjct: 56 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 115 Query: 607 PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLER 666 P + LQE+ + +N + + + F L+++ ++L N + I+ G +++ Sbjct: 116 PEKMP--KTLQELRVHENEITKVRK-SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKK 172 Query: 667 LY---LNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL-PADIGLLQNLQNLAVTANRIEA 722 L + I IP L L L L N +T + A + L NL L ++ N I A Sbjct: 173 LSYIRIADTNITTIPQGL--PPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 230 Query: 723 LPPE-LFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778 + L LR LHL NN L +P + + + + L N + + P Sbjct: 231 VDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPG 287 >5YQ5-A nrPDB Length = 430 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 117/299 (39%), Gaps = 61/299 (20%) Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA---AKIEAPALAFL 491 L IP+ + +L L+ I VT S T LKE+ L H KI+ A L Sbjct: 81 LKTIPNIPMHIQQL-YLQFNEIEAVTAN-SFINATHLKEINLSHNKIKSQKIDYGVFAKL 138 Query: 492 RENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRL----- 546 NL LH++ +++E P + K+LE L L G + +DGL L L Sbjct: 139 -PNLLQLHLEHNNLEEFPFPLP--KSLERL-LLGYNEISKLQTNAMDGLVNLTMLDLCYN 194 Query: 547 ----------------KVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKM 590 K+++L ++L + + L LS+ N I K+ Sbjct: 195 YLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKL 254 Query: 591 VNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 L L + L+ IP++IF+L N+ E+ + N LK Sbjct: 255 PKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLK----------------------Q 292 Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQN 709 YIP NLE LYL N+IEK+ + C + L H LT++ D L+ Sbjct: 293 AFYIPR------NLEHLYLQNNEIEKMNLTVM-CPSIDPLHYHH--LTYIRVDQNKLKE 342 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 61/253 (24%), Positives = 114/253 (45%), Gaps = 14/253 (5%) Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDL--ERIPHSIF 611 ++ + + ++ +H+Q+L + + + NS +L E+ L + ++I + +F Sbjct: 76 CDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVF 135 Query: 612 -SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYL 669 L NL ++ L+ NNL E F L L L YN I+ + + L NL L L Sbjct: 136 AKLPNLLQLHLEHNNL----EEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDL 191 Query: 670 NRNKI--EKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPE 726 N + + ++F KL L+L N L +P GL +L L++ N I ++P + Sbjct: 192 CYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPP--GLPSSLMYLSLENNSISSIPEK 249 Query: 727 LF-QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLV 785 F + KL L + +N LQ +P + L N+ ++ + N+L+ L Sbjct: 250 YFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNE 309 Query: 786 VEEDLFSTLPPEV 798 +E+ + + P + Sbjct: 310 IEKMNLTVMCPSI 322 >4R6F-A nrPDB Length = 331 Score = 179 bits (455), Expect = 4e-45, Method: Composition-based stats. Identities = 87/279 (31%), Positives = 130/279 (46%), Gaps = 22/279 (7%) Query: 512 IYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQ 570 I S++ ++ L L+ N+ I L+EL L L L +N L LPQ V + +L Sbjct: 53 IKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLT 112 Query: 571 KLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTI 629 L+++N + +++ +LT L L ++ I + L NL ++L NNL + Sbjct: 113 TLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARL 172 Query: 630 -------EEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRNKIEKIPTQL 681 I + L LT L L N IP + +LT+L L L+ N I I Q+ Sbjct: 173 WKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQM 232 Query: 682 F-YCRKLRYLDLSHNNLTFL-----PAD----IGLLQNLQNLAVTANRIEALPPELFQ-C 730 L L+LSHNNL L P + L NL L +++N + +P E+F+ Sbjct: 233 LEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDL 292 Query: 731 RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLEC 768 L L+L NN L SLP V E LTNL + L N+L+ Sbjct: 293 TSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 115/273 (42%), Gaps = 28/273 (10%) Query: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505 + L KL I + +LT L L L + + + NL L++ + Sbjct: 68 LALGGNKLHDISA------LKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQL 121 Query: 506 KEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKL------ 558 +P ++ L +L L+L+ N + N +++GL L L + +NL++L Sbjct: 122 TSLPQGVFERLASLTTLNLS-NNNIANINDQMLEGLTNLTTLNLSH--NNLARLWKHANP 178 Query: 559 --PQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHN 615 P +L L++++ G I K + +LT L L ++ I + L N Sbjct: 179 GGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTN 238 Query: 616 LQEIDLKDNNLKTI-------EEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERL 667 L ++L NNL + I + L LT L L N IP + +LT+L L Sbjct: 239 LTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTL 298 Query: 668 YLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTF 699 L+ N++ +P +F L+ L+LS+N L Sbjct: 299 NLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 55.5 bits (132), Expect = 1e-07, Method: Composition-based stats. Identities = 31/99 (31%), Positives = 51/99 (51%), Gaps = 3/99 (3%) Query: 692 LSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVG 751 +++N+ I L N++ LA+ N++ + L + L L+L NN L++LP V Sbjct: 47 IANNSDIKSVQGIQYLPNVRYLALGGNKLHDI-SALKELTNLGWLNLSNNQLETLPQGVF 105 Query: 752 E-LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEED 789 E LTNLT + L N+L LP + E L + L + + Sbjct: 106 EKLTNLTTLNLSNNQLTSLPQGVFE-RLASLTTLNLSNN 143 >5MX0-A nrPDB Length = 362 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 133/313 (42%), Gaps = 55/313 (17%) Query: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKT-LEELHLTGN-LSAENNRYIVIDGLRELKR 545 L F+ ++ ++ + I I ++ T L + L GN ++++ V LR L+R Sbjct: 86 LPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLER 145 Query: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 L + +NL+++P + L++L +++ + N+L+ + NLT L L +++ Sbjct: 146 LYLDH--NNLTRMPGPLPR---SLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQE 200 Query: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLE 665 + S+ L +L +DL YNH+ +P + + LE Sbjct: 201 VGSSMRGLRSLILLDLS-------------------------YNHLRKVPDGL--PSALE 233 Query: 666 RLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFLPADIGLLQNLQN------LAVTAN 718 +LY+ N + +P F KL Y+ LSHN+LT + GL N N L ++ N Sbjct: 234 QLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLT----NNGLASNTFNSSSLLELDLSYN 289 Query: 719 RIEALPPELFQCRKLRALHLGNNVLQSLP-------SRVGELTNLTQIELRGNRLECLPV 771 +++ +PP L L+L N + V + L + L GN ++ + Sbjct: 290 QLQKIPP---VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIKRSAM 346 Query: 772 ELGECPLLKRSGL 784 L+ + L Sbjct: 347 PADAPLCLRLASL 359 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 106/248 (42%), Gaps = 13/248 (5%) Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER--IPHSIF 611 ++ + + V ++ + N I L + L + + +F Sbjct: 78 CDNRNLKYLPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVF 137 Query: 612 S-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYL 669 S L +L+ + L NNL + + L L L +N I+ +P + L NL LYL Sbjct: 138 SKLRHLERLYLDHNNLTRMPGPLP----RSLRELHLDHNQISRVPNNALEGLENLTALYL 193 Query: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQ 729 N+I+++ + + R L LDLS+N+L +P GL L+ L + N + +P F+ Sbjct: 194 QHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD--GLPSALEQLYMEHNNVYTVPDSYFR 251 Query: 730 C-RKLRALHLGNNVLQS--LPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 KL + L +N L + L S ++L +++L N+L+ +P L G + Sbjct: 252 GAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRI 311 Query: 787 EEDLFSTL 794 E S+ Sbjct: 312 NEFSISSF 319 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 56/242 (23%), Positives = 99/242 (40%), Gaps = 13/242 (5%) Query: 531 NNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKL--IVLNSLK 588 +NR + + V + ++ + + V D L ++++ + Sbjct: 79 DNRNLKYLPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFS 138 Query: 589 KMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648 K+ +L L L +L R+P + +L+E+ L N + + + + L LT L L + Sbjct: 139 KLRHLERLYLDHNNLTRMPGPLP--RSLRELHLDHNQISRVPN-NALEGLENLTALYLQH 195 Query: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI-GLL 707 N I + + L +L L L+ N + K+P L L L + HNN+ +P Sbjct: 196 NEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGL--PSALEQLYMEHNNVYTVPDSYFRGA 253 Query: 708 QNLQNLAVTANRIE--ALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNR 765 L + ++ N + L F L L L N LQ +P TNL + L+GNR Sbjct: 254 PKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIP---PVNTNLENLYLQGNR 310 Query: 766 LE 767 + Sbjct: 311 IN 312 Score = 89.8 bits (221), Expect = 5e-18, Method: Composition-based stats. Identities = 50/193 (25%), Positives = 89/193 (46%), Gaps = 14/193 (7%) Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI-- 651 T + +L+ +P F ++ + ++N + +I+E F + L + L N I Sbjct: 74 TAMYCDNRNLKYLP---FVPSRMKYVYFQNNQITSIQE-GVFDNATGLLWIALHGNQITS 129 Query: 652 AYIPIQ-IGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPAD-IGLLQN 709 + + L +LERLYL+ N + ++P L R LR L L HN ++ +P + + L+N Sbjct: 130 DKVGRKVFSKLRHLERLYLDHNNLTRMPGPL--PRSLRELHLDHNQISRVPNNALEGLEN 187 Query: 710 LQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769 L L + N I+ + + R L L L N L+ +P + + L Q+ + N + + Sbjct: 188 LTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLP--SALEQLYMEHNNVYTV 245 Query: 770 PVEL--GECPLLK 780 P G LL Sbjct: 246 PDSYFRGAPKLLY 258 Score = 89.4 bits (220), Expect = 6e-18, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 48/289 (16%) Query: 436 SGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495 G+ D L+ + + ++ D ++L L+ L+L H L +L Sbjct: 108 EGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPG---PLPRSL 164 Query: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555 R LH+ I +P + L L+ L L L+ N Sbjct: 165 RELHLDHNQISRVPN---------------------------NALEGLENLTALYLQHNE 197 Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVN-LTELELIRCDLERIPHSIF-SL 613 + L L ++ + + + + L +L + ++ +P S F Sbjct: 198 IQEVGSSMRGLRSLILLDLSYNHLRKVP----DGLPSALEQLYMEHNNVYTVPDSYFRGA 253 Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673 L + L N+L + + L L L YN + IP TNLE LYL N+ Sbjct: 254 PKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVN---TNLENLYLQGNR 310 Query: 674 IEKIPTQLF-------YCRKLRYLDLSHNNL--TFLPADIGLLQNLQNL 713 I + F KL+ L L N + + +PAD L L +L Sbjct: 311 INEFSISSFCTVVDVVNFSKLQVLRLDGNEIKRSAMPADAPLCLRLASL 359 >4ECN-A nrPDB Length = 876 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 81/370 (21%), Positives = 142/370 (38%), Gaps = 35/370 (9%) Query: 458 DVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKT 517 + P + + + L T + F+ + ++ L I ++ Sbjct: 407 AINRNPEMKPIKKDSRISLKDTQIGNLTNRITFISKAIQRL--TKLQIIYFANSPFTYDN 464 Query: 518 LEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS--NLSKLPQVVTDVGVHLQKLSIN 575 + N LK L + L + N+++LP + D+ LQ L+I Sbjct: 465 IAVDWEDANSDYAKQYENEELSWSNLKDLTDVELYNCPNMTQLPDFLYDLPE-LQSLNIA 523 Query: 576 -NEGTKLIVLNS-LKKM-------VNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNL 626 N G L + ++ + + +LE P S SL + ++ L D Sbjct: 524 CNRGISAAQLKADWTRLADDEDTGPKIQIFYMGYNNLEEFPASA-SLQKMVKLGLLDCVH 582 Query: 627 KTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCR 685 + + +F +LT LKL YN I IP T+ +E L + NK++ IP +F + Sbjct: 583 NKVRHLEAFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIP-NIFNAK 641 Query: 686 K---LRYLDLSHNNLTFLPADIGLLQ------NLQNLAVTANRIEALPPELFQCRK-LRA 735 + +D S+N + +I N + ++ N I+ P ELF + Sbjct: 642 SVYVMGSVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQKFPTELFATGSPIST 701 Query: 736 LHLGNNVLQSLPSR-----VGELTN---LTQIELRGNRLECLPVELGECPLLKRSGLVVE 787 + L NN++ S+P G N LT I+LR N+L L + L S + V Sbjct: 702 IILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLSDDFRATTLPYLSNMDVS 761 Query: 788 EDLFSTLPPE 797 + FS+ P + Sbjct: 762 YNCFSSFPTQ 771 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 72/394 (18%), Positives = 145/394 (36%), Gaps = 56/394 (14%) Query: 351 YSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNE 410 Y+ + EE S+S++ D+ + ++ Y+ + FL ++ E + + N Sbjct: 476 YAKQYENEELSWSNLKDLTD--------VELYNCPNMTQLPDFLYDLPELQSLNIACNRG 527 Query: 411 WTLDKLRQRLTKNAQD-----KLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPS- 464 + +L+ T+ A D K+++ + + + +++KL L+ V Sbjct: 528 ISAAQLKADWTRLADDEDTGPKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVRH 587 Query: 465 ---IAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEEL 521 L +L L + + + + L +K IP I++ K+ + Sbjct: 588 LEAFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIP-NIFNAKS---V 643 Query: 522 HLTGNLSAENNR--------YIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLS 573 ++ G++ N+ +D + + V + + K P + G + + Sbjct: 644 YVMGSVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQKFPTELFATGSPISTII 703 Query: 574 INNEGTKLIVLNSLK-KMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEI 632 ++N I NSLK K N L L IDL+ N L ++ + Sbjct: 704 LSNNLMTSIPENSLKPKDGNYKNTYL-----------------LTTIDLRFNKLTSLSDD 746 Query: 633 ISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR------NKI-EKIPTQLFYCR 685 L L+ + + YN + P Q N + L+ + N+I + PT + C Sbjct: 747 FRATTLPYLSNMDVSYNCFSSFPTQPLNSSQLKAFGIRHQRDAEGNRILRQWPTGITTCP 806 Query: 686 KLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANR 719 L L + N++ + D L L L + N Sbjct: 807 SLIQLQIGSNDIRKV--DEKLTPQLYILDIADNP 838 >5ZSN-B nrPDB Length = 823 Score = 162 bits (410), Expect = 6e-40, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 138/333 (41%), Gaps = 37/333 (11%) Query: 472 KELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN 531 + L L + + L+ L++ I + L + L EL L N Sbjct: 474 QTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQ-TLNGSEFQPLAELR---YLDFSN 529 Query: 532 NRYIVID--GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKK 589 NR ++ EL++L+VL + SN + Q I + +LN K Sbjct: 530 NRLDLLHSTAFEELRKLEVLDISSN-----------SHYFQSEGITH------MLNFTKN 572 Query: 590 MVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI------EEIISFQHLHRLTC 643 + L +L + D+ +L+ ++ + N+L + + F++L +L Sbjct: 573 LKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEE 632 Query: 644 LKLWYNHIAYIPIQ--IGNLTNLERLYLNRNKIEK-IPTQLFYCRKLRYLDLSHNNLTFL 700 L + N ++++P G NL+ L L +N ++ I +L Y + L LDLSHN LT + Sbjct: 633 LDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTV 692 Query: 701 PADIG-LLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVGE---LTN 755 P + ++L+NL + N+I +L Q +LR L L +N +Q + L N Sbjct: 693 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNN 752 Query: 756 LTQIELRGNRLECLPVELGECPLLKRSGLVVEE 788 L + L NR C + ++ + + + Sbjct: 753 LKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPY 785 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 98/414 (23%), Positives = 153/414 (36%), Gaps = 66/414 (15%) Query: 438 IPDTVFD-LVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAPALAFLR--E 493 IP FD L EL+VL+L +PP + L+EL L E FL Sbjct: 259 IPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLP 318 Query: 494 NLRALHIKFTDIKEIPLWIY-----------SLKTLEELHLTGNLSAENNRYIVIDGLRE 542 NL L + F L +Y SLK+L+ L + G + + + + L Sbjct: 319 NLIQLDLSFN----FELQVYRASMNLSQAFSSLKSLKILRIRGYV-FKELKSFQLSPLHN 373 Query: 543 LKRLKVLRLKSNLSKLPQV-VTDVGVHLQKLSINNEGTK-----LIVLNSLKKMVNLTEL 596 L+ L+VL L +N K+ + + L+ + ++ L+ S ++ Sbjct: 374 LQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGSSNARTSVESY 433 Query: 597 ELI---------------RCDLERIPHSIFSLHNL-----QEIDLKDNNLKTIEEIISFQ 636 E C + S S+ Q +DL N++ I+ FQ Sbjct: 434 EPQVLEQLYYFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKS-SDFQ 492 Query: 637 HLHRLTCLKLWYNHIAYI--PIQIGNLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLS 693 HL L CL L N I+ + L L L + N+++ + + F RKL LD+S Sbjct: 493 HLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDIS 552 Query: 694 HNNLTFLPADIGLLQN-------LQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSL 746 N+ F I + N LQ L + N I + + LR L N L L Sbjct: 553 SNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVL 612 Query: 747 PSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKE 800 ++L N L+ L E + K S + +F +PP +K Sbjct: 613 WRDGDN----RYLQLFKNLLK-----LEELDISKNSLSFLPSGVFDGMPPNLKN 657 Score = 89.0 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 81/392 (20%), Positives = 133/392 (33%), Gaps = 80/392 (20%) Query: 465 IAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS-LKTLEELHL 523 LT LK L L L L L++ I EI ++ L L+ L L Sbjct: 178 FLNLTKLKVLSLKDNNVTTVPTV---LPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDL 234 Query: 524 TGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIV 583 +GN N ++ ++P D L+ L +++ + + Sbjct: 235 SGNCPRCYNAPFPCTP----------CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVP 284 Query: 584 LNSLKKMVNLTELELIRCDL-ERIPHSIFS--LHNLQEIDLKDN-----NLKTIEEIISF 635 K + NL EL+L + L + I + F L NL ++DL N ++ +F Sbjct: 285 PRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAF 344 Query: 636 QHLHRLTCLKLWYNHIAYIP----IQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYL 690 L L L++ + + NL NLE L L N I+ +F ++L+ + Sbjct: 345 SSLKSLKILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI 404 Query: 691 DLSHNNL-------------------------------------------------TFLP 701 DLS N + +F Sbjct: 405 DLSVNKISPSGDSLVPRGSSNARTSVESYEPQVLEQLYYFRYDKYARSCRFKNKEASFTS 464 Query: 702 ADIGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVL-QSLP-SRVGELTNLTQ 758 + Q L ++ N I + FQ L+ L+L N++ Q+L S L L Sbjct: 465 VQESCYKYGQTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRY 524 Query: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDL 790 ++ NRL+ L E L K L + + Sbjct: 525 LDFSNNRLDLLHSTAFE-ELRKLEVLDISSNS 555 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 102/247 (41%), Gaps = 21/247 (8%) Query: 445 LVELEVLKLELIP-DVTIPPSIAQLTGLKELWLYHTAAKIEAP------ALAFLRENLRA 497 L EL L D+ + +L L+ L + + ++ + L+ Sbjct: 519 LAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK 578 Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNL-----SAENNRYIVIDGLRELKRLKVLRLK 552 L + DI ++L L GN +NRY+ + + L +L+ L + Sbjct: 579 LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQL--FKNLLKLEELDIS 636 Query: 553 SN-LSKLPQVVTD-VGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 N LS LP V D + +L+ LS+ G K + L+ + NL L+L L +P + Sbjct: 637 KNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERL 696 Query: 611 FS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN---LTNLER 666 + +L+ + LK+N ++++ + Q +L L L N I I L NL+ Sbjct: 697 SNCSRSLKNLILKNNQIRSLTKY-FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKM 755 Query: 667 LYLNRNK 673 L L+ N+ Sbjct: 756 LLLHHNR 762 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 98/308 (31%), Gaps = 55/308 (17%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 + +N + + EIP I + T L + L L + Sbjct: 20 VSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISP------ASFHRLVHLVEID 73 Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHS- 609 + N V + L S I S + L L L L IP Sbjct: 74 FRCNC---------VPIRLGSKSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL 124 Query: 610 ---------------------IFSLHNLQEIDLKDNNLKTIEEIIS-------FQHLHRL 641 + L N++ + L N +S F +L +L Sbjct: 125 PPSLQLLSLEANNIFSIRKEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKL 184 Query: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFL 700 L L N++ +P + + L LYL N I +I F +L+ LDLS N Sbjct: 185 KVLSLKDNNVTTVPTVL--PSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCY 242 Query: 701 PADIGLLQNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSLPSR-VGELTNLTQ 758 A N +P F +L+ L L +N LQ +P R + NL + Sbjct: 243 NAPFPCTP------CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQE 296 Query: 759 IELRGNRL 766 ++L N L Sbjct: 297 LDLSQNFL 304 Score = 59.7 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 50/256 (19%), Positives = 81/256 (31%), Gaps = 52/256 (20%) Query: 586 SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLK 645 +L N ++ L IP I + + + N++ I SF L L + Sbjct: 17 TLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTI--NHIPDISPA-SFHRLVHLVEID 73 Query: 646 LWYN---------------HIAYIPIQIGNLTNLERLYLNRNKIEKIP------------ 678 N + P LT L+ LYL+ N++ +IP Sbjct: 74 FRCNCVPIRLGSKSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSL 133 Query: 679 ----------TQLFYCRKLRYLDLSHN---------NLTFLPADIGLLQNLQNLAVTANR 719 QL + L L N + + L L+ L++ N Sbjct: 134 EANNIFSIRKEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNN 193 Query: 720 IEALPPELFQCRKLRALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRLECLPVELGECPL 778 + +P L L L+L NN++ + L L ++L GN C P Sbjct: 194 VTTVPTVL--PSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPC 251 Query: 779 LKRSGLVVEEDLFSTL 794 S L + + F L Sbjct: 252 KNNSPLQIPVNAFDAL 267 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 29/142 (20%), Positives = 56/142 (39%), Gaps = 10/142 (7%) Query: 444 DLVELEVLKLELIPDVTIPPSIAQLT--GLKELWLYHTAAKIEAPALAFLRENLRALHIK 501 +L++LE L + +P + LK L L K +NL L + Sbjct: 626 NLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLS 685 Query: 502 FTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQ 560 + +P + + ++L+ L L N +Y + D + L+ L L SN ++ Q Sbjct: 686 HNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQ----LRYLDLSSNKIQMIQ 741 Query: 561 V---VTDVGVHLQKLSINNEGT 579 +V +L+ L +++ Sbjct: 742 KTSFPENVLNNLKMLLLHHNRF 763 >6HKW-A nrPDB Length = 363 Score = 156 bits (395), Expect = 3e-38, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 134/292 (45%), Gaps = 13/292 (4%) Query: 514 SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLS 573 ++T+ ++ + R I+G LK++K L L+ NL K + + ++ L++L Sbjct: 71 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ-SLRELD 129 Query: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII 633 + + K I +L+ + L L++ L I + L L+++ L +N + IE Sbjct: 130 LYDNQIKKI--ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKIE--- 183 Query: 634 SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLS 693 + +LH+L L+L N I I I LTNLE L+L +NKI K+ L L L + Sbjct: 184 NLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQ-NLDALTNLTVLSMQ 241 Query: 694 HNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGEL 753 N LT + + L NL+ L ++ N IE + L KL L + +N ++ + + L Sbjct: 242 SNRLTKI-EGLQNLVNLRELYLSHNGIEVIE-GLENNNKLTMLDIASNRIKKI-ENISHL 298 Query: 754 TNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRA 805 T L + + N LE +L E + V E P+ + ++ A Sbjct: 299 TELQEFWMNDNLLESWS-DLDELKGARSLETVYLERNPLQKDPQYRRKVMLA 349 Score = 113 bits (282), Expect = 4e-25, Method: Composition-based stats. Identities = 76/279 (27%), Positives = 121/279 (43%), Gaps = 21/279 (7%) Query: 472 KELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN 531 +++ L H + + ++ L ++ IK I + L++L EL L N Sbjct: 82 EDVDLNHYRIGKIEGFE--VLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDN----- 133 Query: 532 NRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV 591 + I+ L L L++L + NL + + V D L+KL + N I +L + Sbjct: 134 -QIKKIENLEALTELEILDISFNLLRNIEGV-DKLTRLKKLFLVNNKISKI--ENLSNLH 189 Query: 592 NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 L LEL + I +I +L NL+ + L N + + + L LT L + N + Sbjct: 190 QLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL---QNLDALTNLTVLSMQSNRL 245 Query: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711 I + NL NL LYL+ N IE I L KL LD++ N + + +I L LQ Sbjct: 246 TKI-EGLQNLVNLRELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQ 302 Query: 712 NLAVTANRIEALP--PELFQCRKLRALHLGNNVLQSLPS 748 + N +E+ EL R L ++L N LQ P Sbjct: 303 EFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQ 341 Score = 66.3 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 113/251 (45%), Gaps = 29/251 (11%) Query: 416 LRQRLTKNAQD--------KLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQ 467 LRQ L K ++ +L+L+ + I + + L ELE+L + I + + Sbjct: 108 LRQNLIKCIENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNIEG-VDK 165 Query: 468 LTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNL 527 LT LK+L+L + ENL LH ++ + L ++ +E + NL Sbjct: 166 LTRLKKLFLVNNKISKI--------ENLSNLH----QLQMLELGSNRIRAIENIDTLTNL 213 Query: 528 SA---ENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVL 584 + N+ + L L L VL ++SN + + ++ V+L++L +++ G ++I Sbjct: 214 ESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL-VNLRELYLSHNGIEVI-- 270 Query: 585 NSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644 L+ LT L++ +++I +I L LQE + DN L++ ++ + L + Sbjct: 271 EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETV 329 Query: 645 KLWYNHIAYIP 655 L N + P Sbjct: 330 YLERNPLQKDP 340 >5LFN-A nrPDB Length = 337 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 72/279 (25%), Positives = 108/279 (38%), Gaps = 67/279 (24%) Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVL----------NSLKKMVNLTELELIRCDL 603 S L V+ D V LQK+ +E TKL+ L NS + M NL L L C + Sbjct: 7 CHSDLQHVICD-KVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQI 65 Query: 604 ERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNL 661 + F L L + L N+++ + +F L LT L L +N + +P + L Sbjct: 66 REVAAGAFRGLKQLIYLYLSHNDIRVLRA-GAFDDLTELTYLYLDHNKVTELPRGLLSPL 124 Query: 662 TNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPAD----------------- 703 NL L LN NKI ++ F K LR+L LS N L+ L Sbjct: 125 VNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQ 184 Query: 704 --------IGLLQNLQNLAVTANRIEALPPELFQC------------------------- 730 + L+ ++ L ++ N ++++P FQ Sbjct: 185 LSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLG 244 Query: 731 -RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 L+ +HL NN L LPS +L + L N +C Sbjct: 245 VTTLKHVHLENNRLNQLPSN-FPFDSLETLALTNNPWKC 282 Score = 109 bits (273), Expect = 5e-24, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 119/289 (41%), Gaps = 13/289 (4%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRAL 498 P +L+ + + + IP K L L + A NL +L Sbjct: 2 PQNCHCHSDLQHVICDKVGLQKIP---KVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSL 58 Query: 499 HIKFTDIKEIPLWIY-SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 H++ I+E+ + LK L L+L+ + R D L EL L + + +++ Sbjct: 59 HLQHCQIREVAAGAFRGLKQLIYLYLS-HNDIRVLRAGAFDDLTELTYLYLDH--NKVTE 115 Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERI-PHSIFSLHNL 616 LP+ + V+L L +NN + + + + +L L L L + P ++ + NL Sbjct: 116 LPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENL 175 Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL--TNLERLYLNRNKI 674 + + N L + + L + LKL +N + IP LE L+L+ + Sbjct: 176 AKFHVDRNQLSSYPSA-ALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNL 234 Query: 675 EKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEA 722 EK F L+++ L +N L LP++ +L+ LA+T N + Sbjct: 235 EKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPF-DSLETLALTNNPWKC 282 >4R08-A nrPDB Length = 811 Score = 148 bits (373), Expect = 1e-35, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 117/314 (37%), Gaps = 38/314 (12%) Query: 472 KELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN 531 K L L + P ++ L++ + S + L N Sbjct: 462 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNA----QVLSGTEFSAIPHVKYLDLTN 517 Query: 532 NRYIV--IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKK 589 NR L EL L+VL L N + + + + L ++ Sbjct: 518 NRLDFDNASALTELSDLEVLDLSYN-----------SHYFRIAGVTHH------LEFIQN 560 Query: 590 MVNLTELELIRCDLERIPHS-IFSLHNLQEIDLKDNNLKTI------EEIISFQHLHRLT 642 NL L L ++ + +L E+ N L + I F+ L LT Sbjct: 561 FTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLT 620 Query: 643 CLKLWYNHIAYIPIQ--IGNLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTF 699 L L N + +IP + + +L L++N N ++ L +L LDL N L F Sbjct: 621 RLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLF 680 Query: 700 LPADIG-LLQNLQNLAVTANRIEALPPE-LFQCRKLRALHLGNNVLQSLPSRVGE---LT 754 L + +L+ L ++ NRI LP L + L+ L L +N+L+++ E T Sbjct: 681 LTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTT 740 Query: 755 NLTQIELRGNRLEC 768 L+ +EL GN EC Sbjct: 741 KLSMLELHGNPFEC 754 Score = 109 bits (273), Expect = 4e-24, Method: Composition-based stats. Identities = 89/446 (19%), Positives = 150/446 (33%), Gaps = 96/446 (21%) Query: 444 DLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAA--KIEAPALAFLRENLRALHI 500 +L +L L L I + + LK L L +I + A + L L + Sbjct: 263 NLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDL 322 Query: 501 KFTDIK-------EIPLWIYSLKTLEELHLTG-----------------------NLSAE 530 F IK I L +L LHL G NL Sbjct: 323 SFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGIN 382 Query: 531 NNRYIVIDGLRELKRLKVLRLKSNLS---------------------------------- 556 + I + L+++ L N Sbjct: 383 FIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPH 442 Query: 557 ------KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 P + + + L ++ I N + + ++ L L ++ Sbjct: 443 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGT 502 Query: 611 --FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN----HIAYIPIQI---GNL 661 ++ +++ +DL +N L + + L L L L YN IA + + N Sbjct: 503 EFSAIPHVKYLDLTNNRLDF-DNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNF 561 Query: 662 TNLERLYLNRNKIEKIPTQL-FYCRKLRYLDLSHNNLTFLPAD--------IGLLQNLQN 712 TNL+ L L+ N I + + + L L S N L L D L+NL Sbjct: 562 TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTR 621 Query: 713 LAVTANRIEALPPELFQC--RKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNRLECL 769 L ++ NR++ +P E F L LH+ +N+L+ + + + L ++LRGN+L L Sbjct: 622 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFL 681 Query: 770 PVELGECPLLKRSGLVVEEDLFSTLP 795 L + R+ L + + S LP Sbjct: 682 TDSLSDFTSSLRTLL-LSHNRISHLP 706 Score = 98.3 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 73/343 (21%), Positives = 126/343 (36%), Gaps = 32/343 (9%) Query: 453 LELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI-PLW 511 ++ + L L+EL L + L E+L L + +I I Sbjct: 87 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIP---SGLPESLTELSLIQNNIYNITKEG 143 Query: 512 IYSLKTLEELHLTGNLSAENN--RYIVIDG-LRELKRLKVLRLKSNLSKLPQVVTDVGVH 568 I L L+ L+L N + + DG L + L + + L V + Sbjct: 144 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTN--LELLSLSFNSLSHVPPKLPSS 201 Query: 569 LQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKT 628 L+KL ++N K I K ++NLT L+L + Sbjct: 202 LRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP------CDGGASIN 255 Query: 629 IEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRNKIEK-IPTQLFY--C 684 I+ +FQ+L +L L L + I N+ +L+ L L N + I + F Sbjct: 256 IDRF-AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTML 314 Query: 685 RKLRYLDLSHNNLTF-------LPADIGLLQNLQNLAVTANRIEALPPELFQC----RKL 733 +L LDLS N + + + L +L+ L + + L + FQ L Sbjct: 315 PRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNL 374 Query: 734 RALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRLECLPVELGE 775 ++LG N ++ + ++ +NL I L NR+ L + + Sbjct: 375 STINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQ 417 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 98/248 (39%), Gaps = 24/248 (9%) Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNL 616 +L +V VG ++ +L +++ I S + + NLT++ L + + + + Sbjct: 31 RLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQS- 89 Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676 N L + +F +L L L L N + IP + +L L L +N I Sbjct: 90 -------NGLNITD--GAFLNLKNLRELLLEDNQLPQIPSGL--PESLTELSLIQNNIYN 138 Query: 677 I-PTQLFYCRKLRYLDLSHN--------NLTFLPADIGLLQNLQNLAVTANRIEALPPEL 727 I + L+ L L+ N L NL+ L+++ N + +PP+L Sbjct: 139 ITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL 198 Query: 728 FQCRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 LR L L N ++ + + L NLT ++L GN C P + + + Sbjct: 199 --PSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINI 256 Query: 787 EEDLFSTL 794 + F L Sbjct: 257 DRFAFQNL 264 Score = 75.9 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 94/267 (35%), Gaps = 50/267 (18%) Query: 440 DTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALH 499 D L EL L++ + + IA +T L NL+ L+ Sbjct: 523 DNASALTELSDLEVLDLSYNSHYFRIAGVTH--HLEFIQNFT------------NLKVLN 568 Query: 500 IKFTDIKEIPLWI-YSLKTLEELHLTGN------LSAENNRYIVIDGLRELKRLKVLRLK 552 + +I + K+L EL +GN +N + GL+ L RL L L Sbjct: 569 LSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLD-LSLN 627 Query: 553 SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS 612 + ++ L +L IN+ K L++ L L+L L + S+ Sbjct: 628 RLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSD 687 Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN-LTNLERLYLNR 671 + L L L +N I+++P + +++L+ L L+ Sbjct: 688 FTS------------------------SLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSS 723 Query: 672 NKIEKIPTQLFYCR---KLRYLDLSHN 695 N ++ I + KL L+L N Sbjct: 724 NLLKTINKSALETKTTTKLSMLELHGN 750 Score = 31.6 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 23/51 (45%), Gaps = 3/51 (5%) Query: 716 TANRIEALPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNR 765 + R++ +P + + + L L +N + + L NLT+I L N Sbjct: 28 SNRRLQEVPQTV--GKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNP 76 >4QDH-A nrPDB Length = 438 Score = 141 bits (356), Expect = 1e-33, Method: Composition-based stats. Identities = 61/194 (31%), Positives = 89/194 (45%), Gaps = 19/194 (9%) Query: 594 TELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652 T LEL L+ +PH +F L L ++ L NNL TI+ + F +L RL CL L +N IA Sbjct: 38 TRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEM-FVNLSRLQCLSLSHNSIA 96 Query: 653 YI--PIQIGNLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFLPADIGL--- 706 Q LTNL+ L L+ NK++ + F +L+ LDLS+N+ F IG Sbjct: 97 QAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFS 156 Query: 707 ----LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVG-------ELTN 755 L LQ+L++ N I +R L N + + G L+ Sbjct: 157 FVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSG 216 Query: 756 LTQIELRGNRLECL 769 L +++L N L L Sbjct: 217 LLKLDLSQNNLHIL 230 Score = 102 bits (255), Expect = 6e-22, Method: Composition-based stats. Identities = 81/371 (21%), Positives = 139/371 (37%), Gaps = 64/371 (17%) Query: 436 SGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495 +GIP + L ELE KL+ +P +LT L +L L P + L Sbjct: 31 TGIPSSATRL-ELESNKLQSLPHGV----FDKLTQLTKLSLSRNNLVTIKPEMFVNLSRL 85 Query: 496 RALHIKFTDIKEI--PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553 + L + I + L L+ L L+ N EL +L+ L L Sbjct: 86 QCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHN----KLDLYHWKSFSELPQLQALDLSY 141 Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSL 613 N P + +G + + + + L L L D+ S + Sbjct: 142 NSQ--PFSMKGIGHNF---------------SFVTHLSMLQSLSLAHNDIHTRVSSHLNS 184 Query: 614 HNLQEIDLKDNNLKTIEEIIS-----FQHLHRLTCLKLWYNHIAYI-PIQIGN------- 660 ++++ +D N + + + FQ L L L L N++ + P + N Sbjct: 185 NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKL 244 Query: 661 ------------------LTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFL- 700 L NLE L L N+++ + L L+ LD+S N++ + Sbjct: 245 LSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVV 304 Query: 701 PADIGLLQNLQNLAVTANRIEALPPELFQC--RKLRALHLGNNVLQSLPSRVGE-LTNLT 757 PA L L+ + ++ N ++ + F L+ L L N L+S+P + + LT+L Sbjct: 305 PAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPDGIFDRLTSLQ 364 Query: 758 QIELRGNRLEC 768 +I L N +C Sbjct: 365 KIWLHTNPWDC 375 Score = 102 bits (254), Expect = 7e-22, Method: Composition-based stats. Identities = 76/349 (21%), Positives = 131/349 (37%), Gaps = 47/349 (13%) Query: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555 + + +P I S T EL + ++ + V D L +L +L + ++NL Sbjct: 17 TEIRCNSKGLTSVPTGIPSSATRLEL---ESNKLQSLPHGVFDKLTQLTKLSL--SRNNL 71 Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNS-LKKMVNLTELELIRCDLERIPHSIFS-L 613 + + LQ LS+++ V S + NL L+L L+ FS L Sbjct: 72 VTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSEL 131 Query: 614 HNLQEIDLKDNN----LKTIEEIISFQ-HLHRLTCLKLWYNHIAYIPIQIGNLTNLERLY 668 LQ +DL N+ +K I SF HL L L L +N I N ++ L Sbjct: 132 PQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLD 191 Query: 669 LNRNKIEKIPTQ-------LFYCRKLRYLDLSHNNLTFLPA------------------- 702 + N + ++ + L LDLS NNL L Sbjct: 192 FSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNY 251 Query: 703 -------DIGLLQNLQNLAVTANRIEALPPE-LFQCRKLRALHLGNNVLQSLPSRVGELT 754 + L NL+ L + N+++AL L L+ L + +N + S+ L Sbjct: 252 LSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALA 311 Query: 755 -NLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERL 802 L ++ L N L+ + ++ L ++ + ++P + +RL Sbjct: 312 VELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPDGIFDRL 360 Score = 70.5 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 112/333 (33%), Gaps = 87/333 (26%) Query: 427 KLELHLFMLSGIPDTVFD-LVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIE 484 +LEL L +P VFD L +L L L VTI P L+ L+ L L H + Sbjct: 39 RLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQA 98 Query: 485 APALAFLR-ENLRALHIKFTDIKEIPLWIYS----------------------------- 514 FL NL+ L + + +S Sbjct: 99 VNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFV 158 Query: 515 --LKTLEELHLTGN---------LSAENNRYIVIDG----------------LRELKRLK 547 L L+ L L N L++ + R++ G + L L Sbjct: 159 THLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLL 218 Query: 548 VLRLKSNLSKL--PQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 L L N + PQ + ++ L+ LS+ + SL + NL L+L L+ Sbjct: 219 KLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKA 278 Query: 606 IPHSIFS-------------------------LHNLQEIDLKDNNLKTIEEIISFQHLHR 640 + + L+E++L N LKT++ + Sbjct: 279 LTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMN 338 Query: 641 LTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRN 672 L L L N + +P LT+L++++L+ N Sbjct: 339 LKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN 371 >3WPI-A nrPDB Length = 803 Score = 138 bits (348), Expect = 9e-33, Method: Composition-based stats. Identities = 93/385 (24%), Positives = 148/385 (38%), Gaps = 48/385 (12%) Query: 424 AQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAA- 481 Q L LH P+T L LE L L+ T+ S L L L L Sbjct: 248 GQKSLHLH-------PETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLY 300 Query: 482 -KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKT-------LEELHLTGNLSAENNR 533 I LR L++ F K++ L + L+EL++ G + Sbjct: 301 ESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNG-IFFRLLN 359 Query: 534 YIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIV---LNSLKK 589 + L +L +L L L+ N +++ + L+ + +++ + ++ Sbjct: 360 KYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEE 419 Query: 590 MVNLTELELIRCDLERIPHSIFSLHNLQ--------EIDLKDNNLKTIEEIISFQHLHRL 641 + + EL+ D P S + N +DL NNL TI+ + F L RL Sbjct: 420 ADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEM-FVQLSRL 478 Query: 642 TCLKLWYNHIAYI--PIQIGNLTNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLT 698 CL L +N IA Q LTNL+ L L+ NK++ + F +L+ LDLS+N+ Sbjct: 479 QCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQP 538 Query: 699 FLPADIGL-------LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVG 751 F IG L LQ+L++ N I +R L N + + G Sbjct: 539 FSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGG 598 Query: 752 -------ELTNLTQIELRGNRLECL 769 L+ L +++L N L L Sbjct: 599 LYLHFFQGLSGLLKLDLSQNNLHIL 623 Score = 92.1 bits (227), Expect = 8e-19, Method: Composition-based stats. Identities = 81/430 (18%), Positives = 153/430 (35%), Gaps = 65/430 (15%) Query: 417 RQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWL 476 R L ++L L ++ +P LV L + V S+A L L+ L++ Sbjct: 96 RTFLAMRTLEELNLSYNGITTVPRLPSSLVNLSLS--HTNILVLDANSLAGLYSLRVLFM 153 Query: 477 YHT---------AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNL 527 A K+ AL L L L +K+ ++ ++P + +LE L ++ NL Sbjct: 154 DGNCYYKNPCTGAVKVTPGALLGL-SQLTHLSLKYNNLTKVPRQLPP--SLEYLLVSYNL 210 Query: 528 SAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVV-----------------TDVGVHLQ 570 + + L +L L+VL + N + HL+ Sbjct: 211 IV----KLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLE 266 Query: 571 KLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERI--PHSIF-SLHNLQEIDLKDN--- 624 L + + + + + +V L+ L+L L + F +L L++++L N Sbjct: 267 GLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRK 326 Query: 625 --NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ------IGNLTNLERLYLNRNKIEK 676 + + SF++L L L + N I + + + +L L L+L N I + Sbjct: 327 KVSFARLHLASSFKNLVSLQELNM--NGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQ 384 Query: 677 IPTQLFYC-RKLRYLDLSHNNLTF----LPADIGLLQNLQNLAVTANRIEALPPELFQCR 731 +F R LR++DLS N ++ A + + + + P + Sbjct: 385 AQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASK 444 Query: 732 KLR--------ALHLGNNVLQSL-PSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782 + L N L ++ P +L+ L + L N + PL Sbjct: 445 NFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQ 504 Query: 783 GLVVEEDLFS 792 L + + Sbjct: 505 VLDLSHNKLD 514 Score = 84.4 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 115/293 (39%), Gaps = 27/293 (9%) Query: 498 LHIKFTDIKEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556 + + ++ I P L L+ L L+ N A+ L L+VL L N Sbjct: 457 MDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLP---LTNLQVLDLSHNKL 513 Query: 557 KLPQ-VVTDVGVHLQKLSINNEGTKLIVLN------SLKKMVNLTELELIRCDLERIPHS 609 L LQ L ++ + + + L L L D+ S Sbjct: 514 DLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSS 573 Query: 610 IFSLHNLQEIDLKDNNLKTIEEIIS-----FQHLHRLTCLKLWYNHIAYI-PIQIGNLTN 663 + ++++ +D N + + + FQ L L L L N++ + P + NL Sbjct: 574 HLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPK 633 Query: 664 LERLYLNR-NKIEKIPT-QLFYCRKLRYLDLSHNNLTFLPADIGLLQN---LQNLAVTAN 718 +L R N + L + L LDL+ N L L G L N LQ L V++N Sbjct: 634 SLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQ--GTLPNGTLLQKLDVSSN 691 Query: 719 RIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVGE--LTNLTQIELRGNRLEC 768 I ++ P F +L+ ++L +N+L+++ + LT +++R N L C Sbjct: 692 SIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMQLTVLDVRSNPLHC 744 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 45/213 (21%), Positives = 80/213 (37%), Gaps = 28/213 (13%) Query: 567 VHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNL 626 ++ +LS+ + + + + NL +L L L + Sbjct: 42 SNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWN---------CPPTGLSPLHFSC--H 90 Query: 627 KTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR-NKIEKIPTQLFYCR 685 TIE +F + L L L YN I +P ++L L L+ N + L Sbjct: 91 MTIEP-RTFLAMRTLEELNLSYNGITTVPR---LPSSLVNLSLSHTNILVLDANSLAGLY 146 Query: 686 KLRYLDLSHN---------NLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRAL 736 LR L + N + P + L L +L++ N + +P +L L L Sbjct: 147 SLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQL--PPSLEYL 204 Query: 737 HLGNNVLQSL-PSRVGELTNLTQIELRGNRLEC 768 + N++ L P + +LT+L +++ GN C Sbjct: 205 LVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRC 237 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 48/250 (19%), Positives = 95/250 (38%), Gaps = 18/250 (7%) Query: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA----KIEAPALAFLR- 492 +P T +++L KL D+ S ++L L+ L L + + K +F+ Sbjct: 498 LPLTNLQVLDLSHNKL----DLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTH 553 Query: 493 -ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAE--NNRYIVIDGLRELKRLKVL 549 L++L + DI + ++ L +GN + + + + L L L Sbjct: 554 LSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKL 613 Query: 550 RLKSNLSKL--PQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIP 607 L N + PQ + ++ L+ LS+ + SL + NL L+L L+ + Sbjct: 614 DLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALT 673 Query: 608 HSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL--TNL 664 LQ++D+ N++ ++ F L + L +N + + L Sbjct: 674 QGTLPNGTLLQKLDVSSNSIVSVVPA-FFALAVELKEVNLSHNILKTVDRSWFGPIVMQL 732 Query: 665 ERLYLNRNKI 674 L + N + Sbjct: 733 TVLDVRSNPL 742 >3RG1-A nrPDB Length = 612 Score = 137 bits (344), Expect = 3e-32, Method: Composition-based stats. Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%) Query: 552 KSNLSKLPQVVTDVGVHLQK-LSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 + + + + D + + L + I + +++NL L+L RC + + Sbjct: 16 YNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDT 75 Query: 611 F-SLHNLQEIDLKDNNLKTIEE--IISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERL 667 F S H L I L N L + E + + L L + +++ +IP+ NL NLE L Sbjct: 76 FQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVH--NLENLESL 133 Query: 668 YLNRNKIEKIP-TQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAV--TANRIEAL 723 +L N I I + F + L+ LD +N + ++ D L+ NL++ N I+ + Sbjct: 134 HLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGI 193 Query: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761 P F + ++L G ++ + + + + L + L Sbjct: 194 EPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWL 231 Score = 98.6 bits (244), Expect = 9e-21, Method: Composition-based stats. Identities = 73/375 (19%), Positives = 136/375 (36%), Gaps = 38/375 (10%) Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494 G+ D + + L+ + + T T ++EL L + + + Sbjct: 247 FEGLCDMSVESINLQKHRFSDLSSST----FRCFTRVQELDLTAAHLNGLPSGIEGMN-S 301 Query: 495 LRALHIKFTDIKEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553 L+ L + ++ + S +L +L++ GN+ + ++ L L++L + Sbjct: 302 LKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDI 361 Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL--IRCDLERIPHSIF 611 S + HLQ L+++ + + K+ L L++ ++ Sbjct: 362 EASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQ 421 Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL----TNLERL 667 +LH L+ ++L L T + + L L L L N I NL +LE L Sbjct: 422 NLHLLRVLNLSHCLLDTSNQHL-LAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEIL 480 Query: 668 YLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPE 726 L+ + I Q F R + +LDLSHN+LT D L + +N I +PP Sbjct: 481 ILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGLYLNMASNNIRIIPPH 540 Query: 727 LFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 L + L+ + I L N L+C + K + + Sbjct: 541 L----------------------LPALSQQSIINLSHNPLDCTCSNIHFITWYKENLHKL 578 Query: 787 EED--LFSTLPPEVK 799 E+ PP ++ Sbjct: 579 EDSEETTCANPPSLR 593 Score = 82.1 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 77/361 (21%), Positives = 139/361 (38%), Gaps = 31/361 (8%) Query: 431 HLFMLSG-------IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI 483 HLF+ IP + +E L I + +P + LK L + A Sbjct: 108 HLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLPENFPT-QNLKVLDFQNNAIHY 166 Query: 484 EAPALAFLRENLRALHIKFT--DIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR 541 + E L + F DIK I + K + L G+L N +I+ GL+ Sbjct: 167 ISRKDTNSLEQATNLSLNFNGNDIKGIEPGAFISKIFQSLKFGGSL----NLFIIFKGLQ 222 Query: 542 ELKRLKVLRLKSNLSKLPQVVTDVG------VHLQKLSINNEGTKLIVLNSLKKMVNLTE 595 L+ L L + Q +T + ++ +++ + ++ + + E Sbjct: 223 N-STLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQE 281 Query: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN--HIAY 653 L+L L +P I +++L+++ L N+ + +I + L L + N + Sbjct: 282 LDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINA-ASFPSLRDLYIKGNMRKLDL 340 Query: 654 IPIQIGNLTNLERLYLNRNKIEK---IPTQLFYCRKLRYLDLSHNN-LTFLPADIGLLQN 709 + L NL++L L+ + IE QL R L+YL+LS+N L Sbjct: 341 GTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQ 400 Query: 710 LQNLAVTANRIEALPPELF--QCRKLRALHLGNNVLQSLPSR-VGELTNLTQIELRGNRL 766 L+ L V + P LR L+L + +L + + L +L + L+GN Sbjct: 401 LELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQHLLAGLQDLRHLNLQGNSF 460 Query: 767 E 767 + Sbjct: 461 Q 461 >1OGQ-A nrPDB Length = 313 Score = 136 bits (343), Expect = 3e-32, Method: Composition-based stats. Identities = 65/244 (26%), Positives = 100/244 (40%), Gaps = 13/244 (5%) Query: 534 YIVIDGLRELKRLKVLRLK--SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV 591 Y + L L L L + +NL L L I + + + L ++ Sbjct: 66 YPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQIK 125 Query: 592 NLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLKTI--EEIISFQHLHRLTCLKLWY 648 L L+ L +P SI SL NL I N + + SF L T + + Sbjct: 126 TLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKL--FTSMTISR 183 Query: 649 NHI-AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFLPADIGL 706 N + IP NL NL + L+RN +E + LF + + + L+ N+L F +GL Sbjct: 184 NRLTGKIPPTFANL-NLAFVDLSRNMLEGDASVLFGSDKNTQKIHLAKNSLAFDLGKVGL 242 Query: 707 LQNLQNLAVTANRI-EALPPELFQCRKLRALHLG-NNVLQSLPSRVGELTNLTQIELRGN 764 +NL L + NRI LP L Q + L +L++ NN+ +P + G L N Sbjct: 243 SKNLNGLDLRNNRIYGTLPQGLTQLKFLHSLNVSFNNLCGEIP-QGGNLQRFDVSAYANN 301 Query: 765 RLEC 768 + C Sbjct: 302 KCLC 305 Score = 67.1 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 89/243 (36%), Gaps = 15/243 (6%) Query: 438 IPDTVFDLVELEVLKLELIPD--VTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495 IP ++ +L L L + I + IPP+IA+LT L L++ HT P + L Sbjct: 68 IPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQIKTL 127 Query: 496 RALHIKFTDIK-EIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554 L + + +P I SL L + GN + +L + + N Sbjct: 128 VTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAI-PDSYGSFSKL--FTSMTISRN 184 Query: 555 LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLH 614 T ++L + ++ + N ++ L + L + Sbjct: 185 RLTGKIPPTFANLNLAFVDLSRNMLEGDASVLFGSDKNTQKIHLAKNSLAFDLGKVGLSK 244 Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLN--- 670 NL +DL++N + L L L + +N++ IP NL+R ++ Sbjct: 245 NLNGLDLRNNRIYGTLP-QGLTQLKFLHSLNVSFNNLCGEIPQG----GNLQRFDVSAYA 299 Query: 671 RNK 673 NK Sbjct: 300 NNK 302 Score = 58.6 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 7/149 (4%) Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN--RNKIEKIPTQLFYCRKLRYLDLSHNN 696 + L L IP + NL L LY+ N + IP + +L YL ++H N Sbjct: 53 NNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTN 112 Query: 697 LTF-LPADIGLLQNLQNLAVTANRIE-ALPPELFQCRKLRALHLGNNVL-QSLPSRVGEL 753 ++ +P + ++ L L + N + LPP + L + N + ++P G Sbjct: 113 VSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSF 172 Query: 754 TNL-TQIELRGNRLE-CLPVELGECPLLK 780 + L T + + NRL +P L Sbjct: 173 SKLFTSMTISRNRLTGKIPPTFANLNLAF 201 >3B2D-A nrPDB Length = 603 Score = 136 bits (343), Expect = 3e-32, Method: Composition-based stats. Identities = 50/218 (22%), Positives = 93/218 (42%), Gaps = 10/218 (4%) Query: 552 KSNLSKLPQVVTDVGVHLQK-LSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 + + + D + + L + I + +++NLT L+L RC + I Sbjct: 14 YNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDT 73 Query: 611 F-SLHNLQEIDLKDNNLKTIEE--IISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERL 667 F S H L + L N L + E + + L L ++ +++ +IP+ NL NLE L Sbjct: 74 FQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVH--NLENLESL 131 Query: 668 YLNRNKIEKIP-TQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAV--TANRIEAL 723 YL N I I + F R L+ LD +N + ++ D+ L+ NL++ N ++ + Sbjct: 132 YLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI 191 Query: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761 F ++L+ G S+ + + + L Sbjct: 192 ELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWL 229 Score = 98.3 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 81/377 (21%), Positives = 142/377 (37%), Gaps = 40/377 (10%) Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493 ML G+ + + + L+ + I T T L+EL L T K + L Sbjct: 244 MLKGLCEMSVESLNLQEHRFSDISSTT----FQCFTQLQELDLTATHLKGLPSGMKGLN- 298 Query: 494 NLRALHIKFTDIKEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 L+ L + ++ + + +L L++ GN+ + ++ L L+ L + Sbjct: 299 LLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHND 358 Query: 553 SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL--IRCDLERIPHSI 610 S + HLQ L++++ + + K+ L L+L R + Sbjct: 359 IEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPF 418 Query: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL----TNLER 666 +LH LQ ++L L T + + L L L L NH I NL +LE Sbjct: 419 QNLHFLQVLNLTYCFLDTSNQHL-LAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEV 477 Query: 667 LYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPP 725 L L+ + I Q F K+ ++DLSHN+LT I L +L+ + Sbjct: 478 LILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLT--CDSIDSLSHLKGI------------ 523 Query: 726 ELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784 L+L N + + P + L+ + I L N L+C + K + Sbjct: 524 ---------YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLH 574 Query: 785 VV--EEDLFSTLPPEVK 799 + E+ PP ++ Sbjct: 575 KLEGSEETTCANPPSLR 591 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 76/417 (18%), Positives = 148/417 (35%), Gaps = 82/417 (19%) Query: 431 HLFMLSG-------IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAK- 482 HLF++ IP + +E L I + P LK L + A Sbjct: 106 HLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFP-ARNLKVLDFQNNAIHY 164 Query: 483 IEAPALAFLRENL-RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR 541 I + L + + +L+ ++K I L + + L+ G N ++ +GL+ Sbjct: 165 ISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGG----TPNLSVIFNGLQ 220 Query: 542 E-------LKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLT 594 L + + + S + + + ++ ++ L++ I + + L Sbjct: 221 NSTTQSLWLGTFEDIDDEDISSAMLKGLCEM--SVESLNLQEHRFSDISSTTFQCFTQLQ 278 Query: 595 ELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEI---------------------- 632 EL+L L+ +P + L+ L+++ L N+ + +I Sbjct: 279 ELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHL 338 Query: 633 --ISFQHLHRLTCLKLWYNHIAY---IPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRK 686 + L L L L +N I +Q+ NL++L+ L L+ N+ + +Q F C + Sbjct: 339 GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQ 398 Query: 687 LRYLDLSHNNLTFLPAD--------------------------IGLLQNLQNLAVTANRI 720 L LDL+ L + L L++L + N Sbjct: 399 LELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 458 Query: 721 EA---LPPELFQC-RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVE 772 + L Q L L L + L S+ + L ++ ++L N L C ++ Sbjct: 459 QDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSID 515 Score = 59.0 bits (141), Expect = 8e-09, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 84/242 (34%), Gaps = 15/242 (6%) Query: 464 SIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTD--IKEIPLWIYSLKTLEEL 521 + L+ L+ L L H L L + FT I +L L+ L Sbjct: 368 QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVL 427 Query: 522 HLTGNLSAENNRYIVIDGLRELKRLKVL-RLKSNLSKLPQVVTDVGVHLQKLSINNEGTK 580 +LT + + ++ GL L+ L + + + + L+ L +++ G Sbjct: 428 NLT-YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLL 486 Query: 581 LIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640 I + + ++ ++L L S ++L N++ I + L + Sbjct: 487 SIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPI-LSQ 545 Query: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI----PTQLFYCRKLRYLDLSHNN 696 + + L +N + +N+ L + + K+ T LR + LS Sbjct: 546 QSTINLSHNPL------DCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVK 599 Query: 697 LT 698 L+ Sbjct: 600 LS 601 >3T6Q-A nrPDB Length = 606 Score = 133 bits (335), Expect = 3e-31, Method: Composition-based stats. Identities = 52/211 (24%), Positives = 90/211 (42%), Gaps = 9/211 (4%) Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHNL 616 L ++ + + L + I + +++NLT L+L RC + I F S H L Sbjct: 24 LNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRL 83 Query: 617 QEIDLKDNNLKTIEE--IISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674 + L N L + E + + L L ++ + I +IP+ N LE LYL N I Sbjct: 84 DTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLH--NQKTLESLYLGSNHI 141 Query: 675 EKIP-TQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLA--VTANRIEALPPELFQC 730 I + F KL+ LD +N + +L D+ LQ NL+ + N I + P F Sbjct: 142 SSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIEPGAFDS 201 Query: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761 ++L+ G + + + + + + L Sbjct: 202 AVFQSLNFGGTQNLLVIFKGLKNSTIQSLWL 232 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 130/321 (40%), Gaps = 18/321 (5%) Query: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 L+ L + T + E+P + L TL++L L+ N EN I L L +K Sbjct: 278 SGLQELDLTATHLSELPSGLVGLSTLKKLVLSAN-KFENLCQISASNFPSLTHL---SIK 333 Query: 553 SNLSKLPQVVT--DVGVHLQKLSINNE--GTKLIVLNSLKKMVNLTELELIRCDLERIPH 608 N +L + +L++L ++++ T L+ + +L L L + + Sbjct: 334 GNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKT 393 Query: 609 SIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLER 666 F L+ +DL LK + FQ+LH L L L ++ + Q L L+ Sbjct: 394 EAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQH 453 Query: 667 LYLNRNKIEKIP----TQLFYCRKLRYLDLSHNNLTFL-PADIGLLQNLQNLAVTANRIE 721 L L N K L +L L LS +L+ + L+ + ++ ++ NR+ Sbjct: 454 LNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLT 513 Query: 722 ALPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780 + E K L+L +N + + PS + L+ I LR N L+C + K Sbjct: 514 SSSIEALSHLKGIYLNLASNHISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYK 573 Query: 781 RSGLVVE--EDLFSTLPPEVK 799 + +E ED PP ++ Sbjct: 574 ENMQKLEDTEDTLCENPPLLR 594 >4PUF-A nrPDB Length = 637 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 58/188 (30%), Positives = 95/188 (50%), Gaps = 18/188 (9%) Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673 +N E+ LK L TI I Q +T L L N + +P + N++ LY N N+ Sbjct: 50 NNKTELRLKILGLTTIPAYIPEQ----ITTLILDNNELKSLPENLQ--GNIKTLYANSNQ 103 Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKL 733 + IP L ++ ++LS N +T LP L LQ+L + N+I LP L + +L Sbjct: 104 LTSIPATL--PDTIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPE--EL 157 Query: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK--RSGLVVEEDLF 791 R L + +N +++LP+ + + +T + ++ N L LP L P LK +G L Sbjct: 158 RYLSVYDNSIRTLPAHLP--SEITHLNVQSNSLTALPETL--PPGLKTLEAGENALTSLP 213 Query: 792 STLPPEVK 799 ++LPPE++ Sbjct: 214 ASLPPELQ 221 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 111/282 (39%), Gaps = 34/282 (12%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 L+ N L +K + IP +I T L N ++ + ++ L Sbjct: 48 LKNNKTELRLKILGLTTIPAYIPEQITTLIL---DNNELKSLPENLQGNIKTL------- 97 Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVN-LTELELIRCDLERIPHS 609 +N ++L + + +Q++ ++ + +++ + L L+L + +P + Sbjct: 98 -YANSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSALQSLDLFHNKISCLPEN 152 Query: 610 IFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669 + L+ + + DN+++T+ + +T L + N + +P + L+ L Sbjct: 153 LP--EELRYLSVYDNSIRTLPAHLP----SEITHLNVQSNSLTALPETL--PPGLKTLEA 204 Query: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQ 729 N + +P L +L+ LD+S N +T LP L + L V+ N + LP L Sbjct: 205 GENALTSLPASL--PPELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLPENLPA 260 Query: 730 CRKLRALHLGNNVLQSLPSRVGELTNL----TQIELRGNRLE 767 L+ + N L LP + T+I + N Sbjct: 261 A--LQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVEYNPFS 300 Score = 107 bits (266), Expect = 3e-23, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 19/264 (7%) Query: 532 NRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV 591 NR + +R+ + L+ + L + + + L ++N K + N Sbjct: 36 NREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPENLQG--- 92 Query: 592 NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 N+ L L IP ++ +QE++L N + + E + L L L++N I Sbjct: 93 NIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP----SALQSLDLFHNKI 146 Query: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711 + +P + L L + N I +P L ++ +L++ N+LT LP L L+ Sbjct: 147 SCLPENL--PEELRYLSVYDNSIRTLPAHL--PSEITHLNVQSNSLTALPE--TLPPGLK 200 Query: 712 NLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771 L N + +LP L +L+ L + N + LP + +T +++ N L LP Sbjct: 201 TLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPE 256 Query: 772 ELGECPLLKRSGLVVEEDLFSTLP 795 L + ++ L +LP Sbjct: 257 NLPAALQIMQASRNNLVRLPESLP 280 Score = 60.5 bits (145), Expect = 3e-09, Method: Composition-based stats. Identities = 32/226 (14%), Positives = 75/226 (33%), Gaps = 52/226 (23%) Query: 436 SGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495 + +PDT+ ++ EL + ++ +P+ + L+ L L+H L E L Sbjct: 109 ATLPDTIQEM-ELSINRITELPERLP-------SALQSLDLFHNKISCLP---ENLPEEL 157 Query: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555 R L + I+ +P + S ++ L Sbjct: 158 RYLSVYDNSIRTLPAHLPS--------------------------------EITHLNVQS 185 Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHN 615 + L + + L+ L + L L++ + + +P ++ Sbjct: 186 NSLTALPETLPPGLKTLEAGENALTSLPA---SLPPELQVLDVSKNQITVLPETLP--PT 240 Query: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 + +D+ N L + E + L ++ N++ +P + + Sbjct: 241 ITTLDVSRNALTNLPENLP----AALQIMQASRNNLVRLPESLPHF 282 Score = 32.8 bits (73), Expect = 0.58, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 26/58 (44%), Gaps = 2/58 (3%) Query: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKE 800 L ++P+ + E +T + L N L+ LP L + + +TLP ++E Sbjct: 62 LTTIPAYIPE--QITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQE 117 >5Y3M-A nrPDB Length = 801 Score = 131 bits (330), Expect = 9e-31, Method: Composition-based stats. Identities = 94/402 (23%), Positives = 154/402 (38%), Gaps = 47/402 (11%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAPALAFLR--ENL 495 PDT L LE L L+ + L L+ L L L Sbjct: 256 PDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQL 315 Query: 496 RALHIKFTDIKEIPL-------WIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKV 548 R L++ F K++ SL +LE+L + G + + I + L L +L+ Sbjct: 316 RRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHG-IFFRSLTNITLQSLTRLPKLQS 374 Query: 549 LRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLI--VLNSLKKMVNLTEL-----ELIR 600 L L+ N +++ + L + +++ +L ++ + E+ L Sbjct: 375 LHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLPRGLAP 434 Query: 601 CDLERIPH-SIFSLHNLQ-EIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI--PI 656 L+ + NL +DL NNL TI++ + F L RL CL+L +N I+ Sbjct: 435 GPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEM-FTRLSRLQCLRLSHNSISQAVNGS 493 Query: 657 QIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGL-------LQ 708 Q LT+L L L+ NK++ + F +L LDLS+N+ F +G L Sbjct: 494 QFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLP 553 Query: 709 NLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRV-------GELTNLTQIEL 761 +L+ L++ N I + + LRAL N L + + L NL Q++L Sbjct: 554 SLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDL 613 Query: 762 RGNRLEC--------LPVELGECPLLKRSGLVVEEDLFSTLP 795 N L LP L + L + + LP Sbjct: 614 SENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLP 655 Score = 119 bits (298), Expect = 6e-27, Method: Composition-based stats. Identities = 77/331 (23%), Positives = 131/331 (39%), Gaps = 35/331 (10%) Query: 498 LHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556 L + ++ I +++ L L+ L L+ N ++ L L+ VL L N Sbjct: 455 LDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLR---VLDLSHNKL 511 Query: 557 KLPQV--VTDVGVHLQKLSINNE------GTKLIVLNSLKKMVNLTELELIRCDLERIPH 608 L T++ L+ L ++ L+ + ++ +L L L + Sbjct: 512 DLYHGRSFTELPQ-LEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVS 570 Query: 609 SIFSLHNLQEIDLKDNNLKTIEEII-----SFQHLHRLTCLKLWYNHI-AYIPIQIGNLT 662 S +L+ +D N+L + F+ L L L L NH+ +P + NL Sbjct: 571 QKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLP 630 Query: 663 -NLERLYLNRNKIEKIPTQ-LFYCRKLRYLDLSHNNL-----TFLPADIGLLQNLQNLAV 715 +L +L L N + L +L LDL+ N L LP I LQ L V Sbjct: 631 KSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIR----LQKLDV 686 Query: 716 TANRIEALPPELF-QCRKLRALHLGNNVLQSL-PSRVGELTN-LTQIELRGNRLECLPVE 772 ++N I + P F + +L L+L N L+++ PS G L L +++ N L C Sbjct: 687 SSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHCACGA 746 Query: 773 LGECPLLKRSGLV--VEEDLFSTLPPEVKER 801 LL+R V + + P +++ R Sbjct: 747 AFVDFLLERQEAVPGLSRRVTCGSPGQLQGR 777 Score = 114 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 88/390 (22%), Positives = 148/390 (37%), Gaps = 41/390 (10%) Query: 444 DLVELEVLKLE-------LIPDVTIPPSIAQLTGLKELWL----YHTAAKIEAPALAFLR 492 DL +L L L + + S L L++L + + + I +L L Sbjct: 311 DLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLP 370 Query: 493 ENLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551 + L++LH++ I + L I+ + +L + L+ N + G R++V RL Sbjct: 371 K-LQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALG-EVDSRVEVWRL 428 Query: 552 KSNLSKLPQVVTDVGVHLQ------KLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 L+ P + L ++ I ++ L L L + + Sbjct: 429 PRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQ 488 Query: 606 --IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN--- 660 L +L+ +DL N L + SF L +L L L YN + +G+ Sbjct: 489 AVNGSQFVPLTSLRVLDLSHNKLD-LYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLS 547 Query: 661 ----LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPAD-------IGLLQN 709 L +L L L N I +Q LR LD S N+L+ + A+ L+N Sbjct: 548 FVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRN 607 Query: 710 LQNLAVTANRIEALPPELFQC--RKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNRL 766 L L ++ N + L P + LR L L +N L S + L L ++L GN+L Sbjct: 608 LVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQL 667 Query: 767 ECLPVELGECPLLKRSGLVVEEDLFSTLPP 796 + L P ++ L V + + P Sbjct: 668 KALSNG-SLPPGIRLQKLDVSSNSIGFVIP 696 Score = 91.7 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 75/408 (18%), Positives = 145/408 (35%), Gaps = 83/408 (20%) Query: 458 DVTIPPSIAQLTGLKELWLYHT---------AAKIEAPALAFLRENLRALHIKFTDIKEI 508 V P L L+ L++ A ++ AL L NL L +K+ ++ E+ Sbjct: 135 LVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLG-NLTHLSLKYNNLTEV 193 Query: 509 PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKL---------- 558 P + +L+ L L+ N + + L L L+VL + N + Sbjct: 194 PRRLPP--SLDTLLLSYNHIVT----LAPEDLANLTALRVLDVGGNCRRCDHARNPCREC 247 Query: 559 ----PQVVTDVGVHLQK---LSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI- 610 P++ D HL + L + + + + + + L L+L L Sbjct: 248 PKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTT 307 Query: 611 --FSLHNLQEIDLKDN--------NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IG 659 L L+ ++L N +L S L +L +++ + I +Q + Sbjct: 308 IFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLT 367 Query: 660 NLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTF------------------- 699 L L+ L+L N I + +F L ++DLS N ++ Sbjct: 368 RLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWR 427 Query: 700 -----LPADIGLLQN---------LQNLAVTANRIEALPPELF-QCRKLRALHLGNNVLQ 744 P + + + L ++ N + + E+F + +L+ L L +N + Sbjct: 428 LPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSIS 487 Query: 745 SL--PSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790 S+ LT+L ++L N+L+ L L + L + + Sbjct: 488 QAVNGSQFVPLTSLRVLDLSHNKLD-LYHGRSFTELPQLEALDLSYNS 534 Score = 80.9 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 101/250 (40%), Gaps = 18/250 (7%) Query: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAP------ALAFL 491 +P T +++L KL D+ S +L L+ L L + + + Sbjct: 496 VPLTSLRVLDLSHNKL----DLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQ 551 Query: 492 RENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAE--NNRYIVIDGLRELKRLKVL 549 +LR L + I S +L L +GN ++ + + + L+ L L Sbjct: 552 LPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQL 611 Query: 550 RLKSNL--SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIP 607 L N + LP+ + ++ L++L + + +SL + L L+L L+ + Sbjct: 612 DLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALS 671 Query: 608 H-SIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI-PIQIGNLT-NL 664 + S+ LQ++D+ N++ + F RL L L N + + P G+L L Sbjct: 672 NGSLPPGIRLQKLDVSSNSIGFVIP-GFFVRATRLIELNLSANALKTVDPSWFGSLAGTL 730 Query: 665 ERLYLNRNKI 674 + L ++ N + Sbjct: 731 KILDVSANPL 740 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 89/245 (36%), Gaps = 46/245 (18%) Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELI-------------RCDLERIPHSIFSLH 614 ++ LS+ + + + + NL L L C + P++ ++ Sbjct: 43 NVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVP 102 Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN-- 672 L+E++L N + T+ + S L+ + + P L L LY++ N Sbjct: 103 TLEELNLSYNGITTVPALPSSLVSLSLSHTSI----LVLGPTHFTGLHALRFLYMDGNCY 158 Query: 673 -------KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEAL-P 724 +E P L L +L L +NNLT +P L +L L ++ N I L P Sbjct: 159 YMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPR--RLPPSLDTLLLSYNHIVTLAP 216 Query: 725 PELFQCRKLRALHLGN---------NVLQSLPSRVG--------ELTNLTQIELRGNRLE 767 +L LR L +G N + P L+ L + L+ + L Sbjct: 217 EDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLY 276 Query: 768 CLPVE 772 L + Sbjct: 277 KLEKD 281 Score = 67.1 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 57/275 (20%), Positives = 90/275 (32%), Gaps = 63/275 (22%) Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELI 599 L L+VL LK N G+ I N+ + L EL L Sbjct: 62 FVHLSNLRVLNLKWNC-------PPAGLSPMHFPCR----MTIEPNTFLAVPTLEELNLS 110 Query: 600 RCDLERIPHSIF---------------------SLHNLQEIDLKDN-------NLKTIEE 631 + +P LH L+ + + N Sbjct: 111 YNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVA 170 Query: 632 IISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYL 690 + L LT L L YN++ +P ++ +L+ L L+ N I + P L LR L Sbjct: 171 PGALLGLGNLTHLSLKYNNLTEVPRRL--PPSLDTLLLSYNHIVTLAPEDLANLTALRVL 228 Query: 691 DLSHN----------------NLTFL-PADIGLLQNLQNLAVTANRIEALPPELFQC-RK 732 D+ N N L P L L+ L + + + L + F+ + Sbjct: 229 DVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGR 288 Query: 733 LRALHLGNNVL---QSLPSRVGELTNLTQIELRGN 764 L+ L L N L + + +LT L ++ L N Sbjct: 289 LQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFN 323 Score = 64.7 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 51/220 (23%), Positives = 78/220 (35%), Gaps = 48/220 (21%) Query: 592 NLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 N+T L LI + + S F L NL+ ++LK N +H + + N Sbjct: 43 NVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWN-----CPPAGLSPMHFPCRMTIEPNT 97 Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQ---------------------LFYCRKLRY 689 +P LE L L+ N I +P LR+ Sbjct: 98 FLAVP-------TLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRF 150 Query: 690 LDLSHN---------NLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGN 740 L + N L P + L NL +L++ N + +P L L L L Sbjct: 151 LYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRL--PPSLDTLLLSY 208 Query: 741 NVLQSL-PSRVGELTNLTQIELRGN--RLECLPVELGECP 777 N + +L P + LT L +++ GN R + ECP Sbjct: 209 NHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECP 248 >3G06-A nrPDB Length = 622 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 75/327 (22%), Positives = 127/327 (38%), Gaps = 66/327 (20%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 L ++ L I ++ +P L+TLE ++GN +L L VL Sbjct: 59 LPAHITTLVIPDNNLTSLPALPPELRTLE---VSGN---------------QLTSLPVL- 99 Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVN-LTELELIRCDLERIPHS 609 L +LSI + L L + + L +L + L +P Sbjct: 100 ---------------PPGLLELSIFSN-----PLTHLPALPSGLCKLWIFGNQLTSLP-- 137 Query: 610 IFSLHNLQEIDLKDNNLKTIEEIIS-----FQHLHRLTCLKLWYNHIAYIPIQIGNLTNL 664 + LQE+ + DN L ++ + S + + ++LT L + + + + + L +L Sbjct: 138 VLP-PGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASL 196 Query: 665 E-------RLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTA 717 +L+ N++ +P L+ L +S N LT LP L L+ L V+ Sbjct: 197 PTLPSELYKLWAYNNRLTSLPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSG 250 Query: 718 NRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL-ECLPVELGEC 776 NR+ +LP L +L + N L LP + L++ T + L GN L E L E Sbjct: 251 NRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREI 307 Query: 777 P-LLKRSGLVVEEDLFSTLPPEVKERL 802 SG ++ D+ P L Sbjct: 308 TSAPGYSGPIIRFDMAGASAPRETRAL 334 Score = 37.4 bits (85), Expect = 0.028, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 44/113 (38%), Gaps = 18/113 (15%) Query: 435 LSGIPDTVFDLVELEV--LKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLR 492 L+ +P L EL V +L +P + + LKEL + +L L Sbjct: 213 LTSLPALPSGLKELIVSGNRLTSLPVLP--------SELKELMVSGNRLT----SLPMLP 260 Query: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545 L +L + + +P + L + ++L GN +E + LRE+ Sbjct: 261 SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERT----LQALREITS 309 Score = 31.2 bits (69), Expect = 2.0, Method: Composition-based stats. Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 5/59 (8%) Query: 713 LAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771 L V + + LP L + L + +N L SLP+ E L +E+ GN+L LPV Sbjct: 45 LNVGESGLTTLPDCL--PAHITTLVIPDNNLTSLPALPPE---LRTLEVSGNQLTSLPV 98 >6GFF-I nrPDB Length = 618 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 95/383 (24%), Positives = 140/383 (36%), Gaps = 50/383 (13%) Query: 449 EVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI 508 +VL L +P V P + + L L + + LR L + +I + Sbjct: 17 QVLGLLQVPSVLPPDT-------ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFL 69 Query: 509 PLWIY-SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL--SKLPQVVTDV 565 + +L LE L L N A GL L R+ L L N S L + + Sbjct: 70 QPGAFQALTHLEHLSLAHNRLAMATALSA-GGLGPLPRVTSLDLSGNSLYSGLLERLLGE 128 Query: 566 GVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDN 624 L LS+ + ++ + M L +L+L L I F L L ++L N Sbjct: 129 APSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN 188 Query: 625 NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT--NLERLYLNRNKIEKIPTQLF 682 +L I + L +L L L N I L L L NK+ P L Sbjct: 189 SLTCISDF----SLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD-LA 243 Query: 683 YCRKLRYLDLSHN--NLTFLPADIGL-------------------------LQNLQNLAV 715 +L YL+LS+N L P L L NL + Sbjct: 244 ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDL 303 Query: 716 TANRIEALPPELFQ-CRKLRALHLGNNVLQSLPS-RVGELTNLTQIELRGNRLECLPVEL 773 + N IE +P + L L+L N L++ + R+G L L ++L N LE L EL Sbjct: 304 SYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL--EL 361 Query: 774 GECPLLKRSGLVVEEDLFSTLPP 796 G L L+++ + LPP Sbjct: 362 GARALGSLRTLLLQGNALRDLPP 384 Score = 119 bits (297), Expect = 6e-27, Method: Composition-based stats. Identities = 90/416 (21%), Positives = 145/416 (34%), Gaps = 84/416 (20%) Query: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479 L +N+ +L H F +P + ++L L I D + L L L L Sbjct: 137 LAENSLTRLTRHTF--RDMP--ALEQLDLHSNVLMDIEDG----AFEGLPRLTHLNLSRN 188 Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLK--TLEELHLTGNLSAENNRYIVI 537 + + F + LR L + I+ L L L N + + Sbjct: 189 SLTCIS---DFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN------KLLHF 239 Query: 538 DGLRELKRLKVLRLKSNLSKLPQVVT---------------------------DVGVHLQ 570 L L RL L L +NL +LP L Sbjct: 240 PDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 299 Query: 571 KLSINNEGTKLIVLNSLKKMVNLTEL------------------------ELIRCDLERI 606 L ++ +LI + L+ + +L L +L LE + Sbjct: 300 NLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL 359 Query: 607 PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP----------I 656 +L +L+ + L+ N L+ + F +L L L L N ++ + Sbjct: 360 ELGARALGSLRTLLLQGNALRDLPPYT-FANLASLQRLNLQGNRVSPCGGPDEPGPSGCV 418 Query: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN-NLTFLPADIGLLQ-NLQNLA 714 +T+L L L N+IE + F L LDLS N L +G L+ +L+ LA Sbjct: 419 AFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLA 478 Query: 715 VTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770 + N + L +L L+ L+L N L LP+ + +L ++LR N LP Sbjct: 479 LQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPA-WTQAVSLEVLDLRNNSFSLLP 533 Score = 100 bits (248), Expect = 3e-21, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 98/251 (39%), Gaps = 11/251 (4%) Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHNL 616 L QV + + + L ++ + I+ + L L L+L ++ + F +L +L Sbjct: 21 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL 80 Query: 617 QEIDLKDNNLKTIEEI--ISFQHLHRLTCLKLWYNHI--AYIPIQIGNLTNLERLYLNRN 672 + + L N L + L R+T L L N + + +G +L L L N Sbjct: 81 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAEN 140 Query: 673 KIEKIPTQLFY-CRKLRYLDLSHNNLTFLPAD-IGLLQNLQNLAVTANRIEALPPELFQC 730 + ++ F L LDL N L + L L +L ++ N + + F Sbjct: 141 SLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD--FSL 198 Query: 731 RKLRALHLGNNVLQSLPSRVGELTN--LTQIELRGNRLECLPVELGECPLLKRSGLVVEE 788 ++LR L L N +++ + LT ++LR N+L P L+ + Sbjct: 199 QQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLI 258 Query: 789 DLFSTLPPEVK 799 L + P + K Sbjct: 259 RLPTGPPQDSK 269 Score = 98.3 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 96/281 (34%), Gaps = 22/281 (7%) Query: 445 LVELEVLKLELIPDVTIPPSI-AQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFT 503 L +L L L IP S LT L L L + L L + Sbjct: 295 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 354 Query: 504 DIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVT 563 ++ + L +L +L L L GN R + L L+ L L+ N Sbjct: 355 ALETLELGARALGSLRTLLLQGN----ALRDLPPYTFANLASLQRLNLQGNRVSPCGGPD 410 Query: 564 DVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKD 623 + G + + +L L L+ ++E + F L E+DL Sbjct: 411 EPGPS--------------GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSS 456 Query: 624 NNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFY 683 N + L L L N + + + + L+RL L N++ +P Sbjct: 457 NPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPA-WTQ 515 Query: 684 CRKLRYLDLSHNNLTFLPADI--GLLQNLQNLAVTANRIEA 722 L LDL +N+ + LP GL +L+ L + N + Sbjct: 516 AVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC 556 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 105/260 (40%), Gaps = 17/260 (6%) Query: 428 LELHLFMLSGIPDTVF-DLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAK-IE 484 L+L + IPD+ L L L L T + L L L L H A + +E Sbjct: 301 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLE 360 Query: 485 APALAFLRENLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGNLSA-----ENNRYIVID 538 A A +LR L ++ ++++P + + +L +L+ L+L GN + + Sbjct: 361 LGARAL--GSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCV 418 Query: 539 GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV-NLTELE 597 + L+ L L N +L + + L +L +++ + +L + +L L Sbjct: 419 AFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLA 478 Query: 598 LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ 657 L L + + L+ ++L +N L + ++ L L L N + +P Sbjct: 479 LQGNGLMVLQVDLPCFICLKRLNLAENRLS---HLPAWTQAVSLEVLDLRNNSFSLLPGS 535 Query: 658 I--GNLTNLERLYLNRNKIE 675 G T+L RLYL N + Sbjct: 536 AMGGLETSLRRLYLQGNPLS 555 >2FT3-A nrPDB Length = 332 Score = 117 bits (294), Expect = 2e-26, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 116/303 (38%), Gaps = 49/303 (16%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA-KIEAPALAFLRENLRA 497 PDT L++L+ + + L L L L + KI A + LR+ L+ Sbjct: 54 PDTT--LLDLQNNDISELR----KDDFKGLQHLYALVLVNNKISKIHEKAFSPLRK-LQK 106 Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 L+I + EIP + S +L EL + N V GLR + Sbjct: 107 LYISKNHLVEIPPNLPS--SLVELRIHDN-RIRKVPKGVFSGLRNM-------------- 149 Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQ 617 ++G + + S + + L L + L IP + L Sbjct: 150 ---NCIEMGGNPLENSGFE-------PGAFDGL-KLNYLRISEAKLTGIPKDLP--ETLN 196 Query: 618 EIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI-QIGNLTNLERLYLNRNKIEK 676 E+ L N ++ I E+ +L L L +N I I + L L L+L+ NK+ + Sbjct: 197 ELHLDHNKIQAI-ELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSR 255 Query: 677 IPTQLFYCRKLRYLDLSHNNLT------FLPADIGLLQNLQN-LAVTANRIE--ALPPEL 727 +P L + L+ + L NN+T F P G+ + N +++ N + + P Sbjct: 256 VPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNNPVPYWEVQPAT 315 Query: 728 FQC 730 F+C Sbjct: 316 FRC 318 Score = 112 bits (281), Expect = 4e-25, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 104/281 (37%), Gaps = 40/281 (14%) Query: 492 RENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551 +LR + +K +P I TL +L N R GL+ L L Sbjct: 32 HCHLRVVQCSDLGLKAVPKEISPDTTLLDLQ---NNDISELRKDDFKGLQHLYAL----- 83 Query: 552 KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF 611 + N I + + L +L + + L IP ++ Sbjct: 84 ---------------------VLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLP 122 Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA---YIPIQIGNLTNLERLY 668 S +L E+ + DN ++ + + F L + C+++ N + + P L L L Sbjct: 123 S--SLVELRIHDNRIRKVPK-GVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLR 178 Query: 669 LNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAVTANRIEALPPE- 726 ++ K+ IP L L L L HN + + D+ L L + N+I + Sbjct: 179 ISEAKLTGIPKDL--PETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGS 236 Query: 727 LFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767 L LR LHL NN L +P+ + +L L + L N + Sbjct: 237 LSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNIT 277 Score = 109 bits (272), Expect = 6e-24, Method: Composition-based stats. Identities = 58/228 (25%), Positives = 100/228 (43%), Gaps = 12/228 (5%) Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS-LHNL 616 L V ++ L + N + + K + +L L L+ + +I FS L L Sbjct: 45 LKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKL 104 Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRNKIE 675 Q++ + N+L I + L L++ N I +P L N+ + + N +E Sbjct: 105 QKLYISKNHLVEIPPNLP----SSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLE 160 Query: 676 --KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALP-PELFQCRK 732 F KL YL +S LT +P D L + L L + N+I+A+ +L + K Sbjct: 161 NSGFEPGAFDGLKLNYLRISEAKLTGIPKD--LPETLNELHLDHNKIQAIELEDLLRYSK 218 Query: 733 LRALHLGNNVLQSLPS-RVGELTNLTQIELRGNRLECLPVELGECPLL 779 L L LG+N ++ + + + L L ++ L N+L +P L + LL Sbjct: 219 LYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLL 266 Score = 74.8 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 7/172 (4%) Query: 634 SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDL 692 F L ++ + +P +I T L L L N I ++ F + L L L Sbjct: 28 PFGCHCHLRVVQCSDLGLKAVPKEISPDTTL--LDLQNNDISELRKDDFKGLQHLYALVL 85 Query: 693 SHNNLTFL-PADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVG 751 +N ++ + L+ LQ L ++ N + +PP L L L + +N ++ +P V Sbjct: 86 VNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNL--PSSLVELRIHDNRIRKVPKGVF 143 Query: 752 E-LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERL 802 L N+ IE+ GN LE E G LK + L + E + +P ++ E L Sbjct: 144 SGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETL 195 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 44/118 (37%), Gaps = 28/118 (23%) Query: 436 SGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAK------------- 482 SG FD ++L L++ IP + + L EL L H + Sbjct: 162 SGFEPGAFDGLKLNYLRISEAKLTGIPKDLPE--TLNELHLDHNKIQAIELEDLLRYSKL 219 Query: 483 ------------IEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528 IE +L+FL LR LH+ + +P + LK L+ ++L N Sbjct: 220 YRLGLGHNQIRMIENGSLSFL-PTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNI 276 >3CIG-A nrPDB Length = 697 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 92/449 (20%), Positives = 161/449 (35%), Gaps = 78/449 (17%) Query: 396 EVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL 455 ++S N L++ + T+ KL L NAQ L + + +T + L +L Sbjct: 177 DLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLA 236 Query: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI-PLWIYS 514 + T S + T L +L L + +LR L +++ +I+ + P Y Sbjct: 237 TSESTF--SGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYG 294 Query: 515 LKTLEELHLTGNLSAENNRYIVID-----GLRELKRLKVLRLK-SNLSKLPQVVTDVGVH 568 L L L L + ++ + LK L+ L + +N+ V Sbjct: 295 LSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVS 354 Query: 569 LQKLSINNEGTKL--IVLNSLKKMVN--LTELELIRCDLERIPHSIFS-LHNLQEIDLKD 623 L+ LS++ T L + + + + L L L + + +I + FS L L+ +DL Sbjct: 355 LKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGL 414 Query: 624 NNLKTIEEIISFQHLHRLTCLKLWYNHIAYI---------------------------PI 656 N ++ ++ L + + L YN + P Sbjct: 415 NEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPS 474 Query: 657 QIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPAD---------IGL 706 L NL L L+ N I I L L LD HNNL L + Sbjct: 475 PFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKG 534 Query: 707 LQNLQNLAVTANRIEALPPELFQC-------------------------RKLRALHLGNN 741 L +L L + +N ++ +P +F+ LR+L+L N Sbjct: 535 LSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKN 594 Query: 742 VLQSLPSRVG--ELTNLTQIELRGNRLEC 768 ++ S+ V NL +++R N +C Sbjct: 595 LITSVEKDVFGPPFQNLNSLDMRFNPFDC 623 Score = 98.3 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 63/324 (19%), Positives = 114/324 (35%), Gaps = 49/324 (15%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 L N+ L++ ++ +P ++ + + G S + L LK L + Sbjct: 23 LPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQH 82 Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 + LS++ +L +L + + I N K NL +L+L L Sbjct: 83 --NELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGT 140 Query: 611 ---------------------------FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 +L+++DL N LK FQ + +L Sbjct: 141 GVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSP-GCFQTIGKLFA 199 Query: 644 LKLWYNHIA-YIPIQIG---NLTNLERLYLNRNKIEKIPTQLFYC---RKLRYLDLSHNN 696 L L + ++ ++ + T+++ L L N++ F L LDLS+NN Sbjct: 200 LLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNN 259 Query: 697 LTFLP-ADIGLLQNLQNLAVTANRIEAL-PPELFQCRKLRALHL------GNNVLQSLPS 748 L + L +L+ L++ N I+ L P + LR L L + L S P+ Sbjct: 260 LHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPN 319 Query: 749 ----RVGELTNLTQIELRGNRLEC 768 L L + + N + Sbjct: 320 IDDFSFQWLKYLEYLNMDDNNIPS 343 Score = 93.2 bits (230), Expect = 4e-19, Method: Composition-based stats. Identities = 85/378 (22%), Positives = 134/378 (35%), Gaps = 56/378 (14%) Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502 ++ L+ +L I D T T L EL L + ++NL L + Sbjct: 75 LKVLNLQHNELSQISDQT----FVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSH 130 Query: 503 TDIKEIPLWI------------YSLKTL----EELHLTGN-----LSAENNRYIVIDG-- 539 + L K L EEL GN L +N Sbjct: 131 NGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGC 190 Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDV-----GVHLQKLSINNEGTKLIVLNSLKKM--VN 592 + + +L L L +N P + + +Q LS+ N ++ + N Sbjct: 191 FQTIGKLFAL-LLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTN 249 Query: 593 LTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN-- 649 LT+L+L +L + + FS L +L+ + L+ NN++ + SF L L L L Sbjct: 250 LTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSP-RSFYGLSNLRYLSLKRAFT 308 Query: 650 ----HIAYIPI----QIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSH--NNLT 698 +A P L LE L ++ N I + F L+YL LS +L Sbjct: 309 KQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQ 368 Query: 699 FLPADIGLL---QNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQS--LPSRVGE 752 L + + L L +T N I + F +LR L LG N ++ Sbjct: 369 TLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRG 428 Query: 753 LTNLTQIELRGNRLECLP 770 L N+ +I L N+ L Sbjct: 429 LRNIFEIYLSYNKYLQLS 446 Score = 62.0 bits (149), Expect = 9e-10, Method: Composition-based stats. Identities = 30/128 (23%), Positives = 56/128 (43%), Gaps = 6/128 (4%) Query: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFL-PA 702 + + +IP + +N+ L L N++ ++P F +L LD N+++ L P Sbjct: 10 DCSHLKLTHIPDDL--PSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPE 67 Query: 703 DIGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSR-VGELTNLTQIE 760 +L L+ L + N + + + F C L L L +N + + S NL +++ Sbjct: 68 LCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLD 127 Query: 761 LRGNRLEC 768 L N L Sbjct: 128 LSHNGLSS 135 >5Y3K-A nrPDB Length = 802 Score = 115 bits (287), Expect = 1e-25, Method: Composition-based stats. Identities = 79/398 (19%), Positives = 133/398 (33%), Gaps = 83/398 (20%) Query: 440 DTVFDLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAPALAFLR--ENLR 496 DT L LE L L+ + P L L L L + LR Sbjct: 257 DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLR 316 Query: 497 ALHIKFTDIKEIPLWIYSLK-------TLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 L++ F K++ +L +L+EL + G + + + L L L+ L Sbjct: 317 RLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHG-IFFRSLSQKTLQPLARLPMLQRL 375 Query: 550 RLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVL------------------------ 584 L+ N +++ + L+ + +++ V Sbjct: 376 YLQMNFINQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKKVWLTSRDLTPG 435 Query: 585 --------NSLKKMVNLTE-LELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIIS 634 + + NL+ L+L R +L + +F+ L LQ + L N++ Sbjct: 436 PLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQ 495 Query: 635 FQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSH 694 F L L L L +N +L L + +L LDLS+ Sbjct: 496 FVPLTSLQVLDLSHN----------------KLDLYHGR------SFTELPRLEALDLSY 533 Query: 695 NNLTFLPADIGL-------LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLP 747 N+ F +G L L+ L++ N I + + L AL N L + Sbjct: 534 NSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSGNSLSQMW 593 Query: 748 SRV-------GELTNLTQIELRGNRLEC-LPVELGECP 777 + L +L +++L NRL LP LG P Sbjct: 594 AEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLP 631 Score = 110 bits (276), Expect = 2e-24, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 122/339 (35%), Gaps = 28/339 (8%) Query: 487 ALAFLRENLRA-LHIKFTDIKEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELK 544 +NL L + ++ + P L L+ L L+ N ++ L Sbjct: 444 DFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVP---LT 500 Query: 545 RLKVLRLKSNLSKLPQV--VTDVGVHLQKLSINNEGTK------LIVLNSLKKMVNLTEL 596 L+VL L N L T++ L+ L ++ L+ + ++ L L Sbjct: 501 SLQVLDLSHNKLDLYHGRSFTELPR-LEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYL 559 Query: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII-----SFQHLHRLTCLKLWYNHI 651 L + +L +D N+L + FQ L L L L N + Sbjct: 560 SLAHNGIHSRVSQQLCSTSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRL 619 Query: 652 -AYIPIQIGNLT-NLERLYLNRNKIEKIPTQ-LFYCRKLRYLDLSHNNLTFLP-ADIGLL 707 +P +GNL +L+ L L N + L L LDL+ N L L + Sbjct: 620 HTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSG 679 Query: 708 QNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVGEL--TNLTQIELRGN 764 LQ L V+ N I + P F +LR L+L N L+++ +L +++ N Sbjct: 680 TQLQRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSAN 739 Query: 765 RLECLPVELGECPLLKRSGLV--VEEDLFSTLPPEVKER 801 L C LL+ V + + P +++ R Sbjct: 740 PLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGR 778 Score = 104 bits (259), Expect = 2e-22, Method: Composition-based stats. Identities = 73/358 (20%), Positives = 137/358 (38%), Gaps = 30/358 (8%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAK--IEAPALAFLRENLR 496 P +++ L++ I + GL+ + L +E A + + Sbjct: 365 PLARLPMLQRLYLQMNFINQAQLGI-FKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGK 423 Query: 497 ALHIKFTDIKEIPLWIYS----LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 + + D+ PL S + + + L T +LS N + + +L RL+ LRL Sbjct: 424 KVWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLS 483 Query: 553 SNLSKLPQVVTDV--GVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCD----LERI 606 N + LQ L +++ L S ++ L L+L + + Sbjct: 484 HNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRGV 543 Query: 607 PHSIF---SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ------ 657 H++ L L+ + L N + + L L N ++ + + Sbjct: 544 GHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCS--TSLWALDFSGNSLSQMWAEGDLYLR 601 Query: 658 -IGNLTNLERLYLNRNKI-EKIPTQLFYCRK-LRYLDLSHNNLTFLP-ADIGLLQNLQNL 713 L +L RL L++N++ +P L K L+ L L +N L F + + LL NL+ L Sbjct: 602 FFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETL 661 Query: 714 AVTANRIEALPPE-LFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRLECL 769 + N+++AL L +L+ L + N + +P T L ++ L N L + Sbjct: 662 DLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTV 719 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 122/308 (39%), Gaps = 37/308 (12%) Query: 451 LKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAPALAFLR-ENLRALHIKFTDIKEI 508 L L VT+ P AQL+ L+ L L H + F+ +L+ L + + Sbjct: 456 LDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLD-- 513 Query: 509 PLWIYSLKTLEELHLTGNLSAE-NNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV 567 +Y ++ EL L N++ + G+ NLS + Q+ T Sbjct: 514 ---LYHGRSFTELPRLEALDLSYNSQPFSMRGVGH-----------NLSFVAQLPT---- 555 Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHS-------IFSLHNLQEID 620 L+ LS+ + G V L +L L+ L ++ L +L +D Sbjct: 556 -LRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLD 613 Query: 621 LKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYLNRNKIEKI-P 678 L N L T+ L L+L N++A+ + L NLE L L N+++ + Sbjct: 614 LSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSN 673 Query: 679 TQLFYCRKLRYLDLSHNNLTF-LPADIGLLQNLQNLAVTANRIEALPPEL--FQCRKLRA 735 L +L+ LD+S N++ F +P L L+ L ++AN + + P F L Sbjct: 674 GSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEV 733 Query: 736 LHLGNNVL 743 L + N L Sbjct: 734 LDVSANPL 741 Score = 92.1 bits (227), Expect = 9e-19, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 95/300 (31%), Gaps = 30/300 (10%) Query: 422 KNAQDKLELHLFMLSGI-PDTVFDLVELEVLKL--ELIPDVTIPPSIAQLTGLKELWLYH 478 KN L+L L + P+ L L+ L+L I LT L+ L L H Sbjct: 450 KNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSH 509 Query: 479 TAAKIEAPALAFLRENLRALHIKFTDIKEIPLW--------IYSLKTLEELHLTGNLSAE 530 + L AL + + + + + L TL L L N Sbjct: 510 NKLDLYHGRSFTELPRLEALDLSYNS-QPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHS 568 Query: 531 NNRYIVIDGLRELKRLKVLRLKSNL-------SKLPQVVTDVGVHLQKLSINNEGTKLIV 583 + L L N L L +L ++ ++ Sbjct: 569 RVSQQLCS-----TSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLL 623 Query: 584 LNSLKKMVN-LTELELIRCDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRL 641 +L + L L L L S +L NL+ +DL N LK + +L Sbjct: 624 PCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSG-TQL 682 Query: 642 TCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFY--CRKLRYLDLSHNNLT 698 L + N I ++ P T L L L+ N + + F L LD+S N L Sbjct: 683 QRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLH 742 Score = 82.1 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 75/370 (20%), Positives = 127/370 (34%), Gaps = 57/370 (15%) Query: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT-------------AAKIEAPALAFLR 492 + L ++ + D AQL+ L++L L IE Sbjct: 47 LSLLSNRIHHLHD----SDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTF-LAV 101 Query: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 L L++ + I +P SL +L L T L + + LR L K Sbjct: 102 PTLEELNLSYNGITTVPALPSSLVSL-ILSRTNILQLDPTSLTGLHALRFLYMDGNCYYK 160 Query: 553 SNLSKLPQVVTDVGV---HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERI-PH 608 + + +V + +L LS+ + +L L L + + P Sbjct: 161 NPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPR---SLPPSLEYLLLSYNHIVTLAPE 217 Query: 609 SIFSLHNLQEIDLKDN----NLKTIEEIIS-----------FQHLHRLTCLKLWYNHIAY 653 + +L L+ +D+ N + + F HL RL L L + + Sbjct: 218 DLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQ 277 Query: 654 I-PIQIGNLTNLERLYLNRNKIEKIPTQ---LFYCRKLRYLDLSHN---NLTF----LPA 702 + P L NL L L+ N + T+ +LR L+LS N ++F L Sbjct: 278 LNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAP 337 Query: 703 DIGLLQNLQNLAVTANRIEALPPELFQC----RKLRALHLGNNVLQSLPSRVGE-LTNLT 757 G L +LQ L + +L + Q L+ L+L N + + + L Sbjct: 338 SFGSLLSLQELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLR 397 Query: 758 QIELRGNRLE 767 I+L NR+ Sbjct: 398 YIDLSDNRIS 407 Score = 79.8 bits (195), Expect = 5e-15, Method: Composition-based stats. Identities = 50/212 (23%), Positives = 85/212 (40%), Gaps = 28/212 (13%) Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627 ++ LS+ + + + ++ NL +L L P + +H + ++ N Sbjct: 43 NVTSLSLLSNRIHHLHDSDFAQLSNLQKLNL---KWNCPPAGLSPMHFPCHMTIEPNT-- 97 Query: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR-NKIEKIPTQLFYCRK 686 F + L L L YN I +P ++L L L+R N ++ PT L Sbjct: 98 -------FLAVPTLEELNLSYNGITTVP---ALPSSLVSLILSRTNILQLDPTSLTGLHA 147 Query: 687 LRYLDLSHN---------NLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALH 737 LR+L + N L P + L NL +L++ N + +P L L L Sbjct: 148 LRFLYMDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSL--PPSLEYLL 205 Query: 738 LGNNVLQSL-PSRVGELTNLTQIELRGNRLEC 768 L N + +L P + LT L +++ GN C Sbjct: 206 LSYNHIVTLAPEDLANLTALRVLDVGGNCRRC 237 >3J0A-A nrPDB Length = 844 Score = 103 bits (256), Expect = 4e-22, Method: Composition-based stats. Identities = 75/377 (19%), Positives = 134/377 (35%), Gaps = 38/377 (10%) Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA--PALAFLRENLRALHI 500 F L EL + L V L L L L + P+ L +L+++ Sbjct: 97 FHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLN-SLKSIDF 155 Query: 501 KFTDI---KEIPLWIYSLKTLEELHLTGNLSAENNRYI---VIDGLRELKRLKVLRLKSN 554 I E L KTL L N ++ R + L++L + N Sbjct: 156 SSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGN 214 Query: 555 -------------LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV--NLTELELI 599 +SK + H+ K N+ + ++ L+L Sbjct: 215 GWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLS 274 Query: 600 RCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI-PIQ 657 + + +F +L +L+ ++L N + I + +F L L L L YN + + Sbjct: 275 HGFVFSLNSRVFETLKDLKVLNLAYNKINKIADE-AFYGLDNLQVLNLSYNLLGELYSSN 333 Query: 658 IGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVT 716 L + + L +N I I Q F + KL+ LDL N LT I + ++ ++ ++ Sbjct: 334 FYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT----IHFIPSIPDIFLS 389 Query: 717 ANRIEALPPELFQCRKLRALHLGNNVLQSLP--SRVGELTNLTQIELRGNRLECLPVELG 774 N++ LP + HL N L++L + + +L + L NR + Sbjct: 390 GNKLVTLPKINLTANLI---HLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQT 446 Query: 775 ECPLLKRSGLVVEEDLF 791 L + E++ Sbjct: 447 PSENPSLEQLFLGENML 463 Score = 99.0 bits (245), Expect = 7e-21, Method: Composition-based stats. Identities = 71/273 (26%), Positives = 119/273 (43%), Gaps = 27/273 (9%) Query: 540 LRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELEL 598 LK LKVL L N ++K+ +LQ L+++ + ++ + + ++L Sbjct: 286 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 345 Query: 599 IRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ 657 + + I F L LQ +DL+DN L TI I S + + L N + +P + Sbjct: 346 QKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS------IPDIFLSGNKLVTLP-K 398 Query: 658 IGNLTNLERLYLNRNKIEKIPTQLFYC--RKLRYLDLSHNNLTFLPADIGLLQN--LQNL 713 I NL ++L+ N++E + F L+ L L+ N + D +N L+ L Sbjct: 399 INLTANL--IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQL 456 Query: 714 AVTANRIE-----ALPPELFQC-RKLRALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRL 766 + N ++ L ++F+ L+ L+L +N L SLP V LT L + L NRL Sbjct: 457 FLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 516 Query: 767 EC-----LPVELGECPLLKRSGLVVEEDLFSTL 794 LP L + + L D+F +L Sbjct: 517 TVLSHNDLPANLEILDISRNQLLAPNPDVFVSL 549 Score = 81.3 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 114/321 (35%), Gaps = 35/321 (10%) Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502 ++ L K+ I D + L L+ L L + + + + + ++ Sbjct: 292 LKVLNLAYNKINKIAD----EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQK 347 Query: 503 TDIKEIPLWIYS-LKTLEELHLTGN----LSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 I I + L+ L+ L L N + + + +L L + L +NL Sbjct: 348 NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIH 407 Query: 558 LPQVVTDVGV---------HLQKLSINNEGTKLIVLNSL-KKMVNLTELELIRCDLE--- 604 L + + HLQ L +N + + +L +L L L+ Sbjct: 408 LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 467 Query: 605 --RIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661 + +F L +LQ + L N L ++ F HL L L L N + + Sbjct: 468 ETELCWDVFEGLSHLQVLYLNHNYLNSLPP-GVFSHLTALRGLSLNSNRLTVLSHND-LP 525 Query: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL---TFLPADIGLLQNLQNLAVTA- 717 NLE L ++RN++ + L LD++HN L I L + N+ + Sbjct: 526 ANLEILDISRNQL--LAPNPDVFVSLSVLDITHNKFICECELSTFINWLNH-TNVTIAGP 582 Query: 718 -NRIEALPPELFQCRKLRALH 737 I + P+ F L +L Sbjct: 583 PADIYCVYPDSFSGVSLFSLS 603 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 74/361 (20%), Positives = 125/361 (34%), Gaps = 38/361 (10%) Query: 457 PDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLW---IY 513 P + L L+ L L + P +L L + F + + L Sbjct: 61 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 120 Query: 514 SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLS 573 +LK L L L+ N + L LK + + L ++ G L S Sbjct: 121 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 180 Query: 574 INNEGTKLIV-------LNSLKKMVNLTELELIRC----DLERIPHSIFSLHNLQEIDLK 622 + V +N + MV L L++ D+ + S + L Sbjct: 181 LAANSLYSRVSVDWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 239 Query: 623 DN--------NLKTIEEIISFQHLHRLTC--LKLWYNHIAYI-PIQIGNLTNLERLYLNR 671 + + + +F L R + L L + + + L +L+ L L Sbjct: 240 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 299 Query: 672 NKIEKIPTQLFY-CRKLRYLDLSHNNLTFL-PADIGLLQNLQNLAVTANRIEALPPELFQ 729 NKI KI + FY L+ L+LS+N L L ++ L + + + N I + + F+ Sbjct: 300 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK 359 Query: 730 -CRKLRALHLGNNVLQ------SLPS---RVGELTNLTQIELRGNRLECLPVELGECPLL 779 KL+ L L +N L S+P +L L +I L N + L +L Sbjct: 360 FLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDIL 419 Query: 780 K 780 Sbjct: 420 Y 420 Score = 72.4 bits (176), Expect = 8e-13, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 91/265 (34%), Gaps = 37/265 (13%) Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER--IPHSIF-SLHNLQEIDLKDN 624 +L+ L + + + ++ + + +L EL L C L + F +L L +DL N Sbjct: 74 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 133 Query: 625 NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL---TNLERLYLNRNKIEKIPT-- 679 ++++ SF L+ L + N I + L L N + + Sbjct: 134 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVD 193 Query: 680 -----QLFYCRKLRYLDLSHNN----LTFLPADIGLLQNLQNLAVTA---------NRIE 721 F L LD+S N +T ++ +L + + I+ Sbjct: 194 WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIK 253 Query: 722 ALPPELFQC---RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVE----- 772 F +R L L + + SL SRV E L +L + L N++ + E Sbjct: 254 DPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGL 313 Query: 773 --LGECPLLKRSGLVVEEDLFSTLP 795 L L + F LP Sbjct: 314 DNLQVLNLSYNLLGELYSSNFYGLP 338 Score = 55.9 bits (133), Expect = 8e-08, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 84/243 (34%), Gaps = 31/243 (12%) Query: 429 ELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI----- 483 EL+ G+P + ++L+ + +I D T L L+ L L A Sbjct: 328 ELYSSNFYGLPKVAY--IDLQKNHIAIIQDQT----FKFLEKLQTLDLRDNALTTIHFIP 381 Query: 484 EAPALAFLRENLRAL----------HIKFTDIKEIPLWIYSLKT--LEELHLTGNLSAEN 531 P + L L H+ ++ + + + L+ L+ L L N + Sbjct: 382 SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 441 Query: 532 NRYIVID---GLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 + L +L + + + ++L V + HLQ L +N+ + Sbjct: 442 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFS 501 Query: 589 KMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648 + L L L L + H+ NL+ +D+ N L + L+ L + + Sbjct: 502 HLTALRGLSLNSNRLTVLSHNDLP-ANLEILDISRNQLL----APNPDVFVSLSVLDITH 556 Query: 649 NHI 651 N Sbjct: 557 NKF 559 >3A7C-A nrPDB Length = 580 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 67/371 (18%), Positives = 144/371 (38%), Gaps = 53/371 (14%) Query: 445 LVELEVLKLELIPDVTI-PPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFT 503 L L L+++ + S+ + + L L+ + + A + ++R L ++ T Sbjct: 173 LTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDT 232 Query: 504 DIKEI---PLWIYSLKT-LEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN----- 554 ++ PL + + + +++L G++ + + ++ LR + L + Sbjct: 233 NLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGL 292 Query: 555 -------------LSKLPQVVTDVGVHLQ------------------KLSINNEGTKLIV 583 L K+ V Q ++++ N L+ Sbjct: 293 GDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVP 352 Query: 584 LNSLKKMVNLTELELIRC----DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIIS-FQHL 638 + + + +L L+L + + + +LQ + L N+L+++++ L Sbjct: 353 CSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTL 412 Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 LT L + N +P + L L+ I + T + + L LD+S+NNL Sbjct: 413 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCI--PQTLEVLDVSNNNLD 470 Query: 699 FLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGE-LTNLT 757 L LQ L ++ N+++ LP L + + +N L+S+P + + LT+L Sbjct: 471 SFSL---FLPRLQELYISRNKLKTLPD-ASLFPVLLVMKIASNQLKSVPDGIFDRLTSLQ 526 Query: 758 QIELRGNRLEC 768 +I L N +C Sbjct: 527 KIWLHTNPWDC 537 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Query: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAVTANRIEALPPELFQC-RK 732 IP+ L ++ LDLS N +T++ D+ NLQ L + ++RI + + F Sbjct: 44 TSIPSGL--TAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 101 Query: 733 LRALHLGNNVLQSLPSR-VGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 L L L +N L SL S G L++L + L GN + L V L L + Sbjct: 102 LEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRI 156 Score = 57.0 bits (136), Expect = 4e-08, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%) Query: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLE 604 +K L L N ++ + +LQ L + + I ++ + +L L+L L Sbjct: 54 MKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLS 113 Query: 605 RIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY----NHIAYIPIQIG 659 + S F L +L+ ++L N +T+ F +L L L++ + I I Sbjct: 114 SLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRID--FA 171 Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYL-DLSHNNLT 698 LT+L L +I+ + + + + L+ + D+ H L Sbjct: 172 GLTSLNEL-----EIKALSLRNYQSQSLKSIRDIHHLTLH 206 Score = 53.2 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 7/119 (5%) Query: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFLPAD-IGLL 707 IP + ++ L L+ NKI I L C L+ L L + + + D L Sbjct: 42 SFTSIPSGLT--AAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 99 Query: 708 QNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSL--PSRVGELTNLTQIELRG 763 +L++L ++ N + +L F L+ L+L N Q+L S LTNL + + Sbjct: 100 GSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGN 158 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 42/99 (42%), Gaps = 3/99 (3%) Query: 698 TFLPADIGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVG-ELTN 755 +F GL +++L ++ N+I + + C L+ L L ++ + ++ L + Sbjct: 42 SFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 101 Query: 756 LTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTL 794 L ++L N L L PL L + + + TL Sbjct: 102 LEHLDLSDNHLSSLSSSWFG-PLSSLKYLNLMGNPYQTL 139 >1JL5-A nrPDB Length = 454 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 133/336 (39%), Gaps = 44/336 (13%) Query: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELH-----------LTGNLSAENNRYIV 536 L L +L +L + E+P SLK+L + L L NN+ Sbjct: 86 LPELPPHLESLVASCNSLTELPELPQSLKSLLVDNNNLKALSDLPPLLEYLGVSNNQLEK 145 Query: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTEL 596 + L+ LK++ + +N K + D+ L+ ++ N + + L+ + LT + Sbjct: 146 LPELQNSSFLKIIDVDNNSLK---KLPDLPPSLEFIAAGNNQLEELPE--LQNLPFLTAI 200 Query: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI 656 L+++P SL ++ + NN+ +EE+ Q+L LT + N + +P Sbjct: 201 YADNNSLKKLPDLPLSLESI----VAGNNI--LEELPELQNLPFLTTIYADNNLLKTLPD 254 Query: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVT 716 +LE L + N + +P + L +LD+S N + L L NL L + Sbjct: 255 ---LPPSLEALNVRDNYLTDLPE---LPQSLTFLDVSENIFSGLSE---LPPNLYYLNAS 305 Query: 717 ANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL--------TQIELRGN--RL 766 +N I +L L L++ NN L LP+ L L EL N +L Sbjct: 306 SNEIRSLCD---LPPSLEELNVSNNKLIELPALPPRLERLIASFNHLAEVPELPQNLKQL 362 Query: 767 ECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERL 802 L E P + S + + PE+ + L Sbjct: 363 HVEYNPLREFPDIPESVEDLRMNSHLAEVPELPQNL 398 Score = 86.3 bits (212), Expect = 5e-17, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 126/310 (40%), Gaps = 43/310 (13%) Query: 502 FTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQ- 560 +++ E+P+ ++K+ E + G E + + V RL+ L + Sbjct: 20 SSNLTEMPVEAENVKSKTEY----YNAWSEWERNAPPGNGEQREMAVSRLRDCLDRQAHE 75 Query: 561 ---------VVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF 611 + ++ HL+ L + + + +L L + +L+ + + Sbjct: 76 LELNNLGLSSLPELPPHLESLVASCNSLTELP----ELPQSLKSLLVDNNNLKAL-SDLP 130 Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671 L L+ + + +N L+ + E+ + L + + N + +P +LE + Sbjct: 131 PL--LEYLGVSNNQLEKLPELQNSSFLK---IIDVDNNSLKKLPD---LPPSLEFIAAGN 182 Query: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCR 731 N++E++P L L + +N+L LP L +L+++ N +E LP EL Sbjct: 183 NQLEELPE-LQNLPFLTAIYADNNSLKKLPD---LPLSLESIVAGNNILEELP-ELQNLP 237 Query: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLF 791 L ++ NN+L++LP +L + +R N L LP L V E++F Sbjct: 238 FLTTIYADNNLLKTLPDLPP---SLEALNVRDNYLTDLPELPQSLTFL-----DVSENIF 289 Query: 792 ST---LPPEV 798 S LPP + Sbjct: 290 SGLSELPPNL 299 Score = 37.0 bits (84), Expect = 0.031, Method: Composition-based stats. Identities = 43/194 (22%), Positives = 76/194 (39%), Gaps = 29/194 (14%) Query: 434 MLSGIPDTVFDLVELEV--LKLELIPDVTIPPSIAQLT-----GLKEL--WLYH-TAAKI 483 +L +PD L L V L +P++ + ++ GL EL LY+ A+ Sbjct: 248 LLKTLPDLPPSLEALNVRDNYLTDLPELPQSLTFLDVSENIFSGLSELPPNLYYLNASSN 307 Query: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543 E +L L +L L++ + E+P LE L + N AE Sbjct: 308 EIRSLCDLPPSLEELNVSNNKLIELP---ALPPRLERLIASFNHLAEVPELP-------- 356 Query: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDL 603 + LK L ++ N + D+ ++ L +N+ ++ L NL +L + L Sbjct: 357 QNLKQLHVEYNPLR---EFPDIPESVEDLRMNSHLAEVPELPQ-----NLKQLHVETNPL 408 Query: 604 ERIPHSIFSLHNLQ 617 P S+ +L+ Sbjct: 409 REFPDIPESVEDLR 422 >5Y31-B nrPDB Length = 544 Score = 100 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 42/156 (26%), Positives = 71/156 (45%), Gaps = 7/156 (4%) Query: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPAD-IGLL 707 + IP + ++ L R+ +I F + L+ L + N+ + D L Sbjct: 37 NARSIPRTV--PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL 94 Query: 708 QNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNR 765 +L+ L + N I+++ F+ + L L L NN LQ+LP + + L +LT ++LRGN Sbjct: 95 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 154 Query: 766 LECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKER 801 C L + V ED++ PPE K+R Sbjct: 155 FNCDCKLKWLVEWLGHTNATV-EDIYCEGPPEYKKR 189 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 49/107 (45%), Gaps = 2/107 (1%) Query: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 + + ++S +++ + LQ L + +I ++ + +L L + +++ Sbjct: 50 ISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS 109 Query: 606 IPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 I F L +L + L +NNL+T+ + I F+ L LT + L N Sbjct: 110 ISRHTFRGLKSLIHLSLANNNLQTLPKDI-FKGLDSLTNVDLRGNSF 155 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 46/119 (38%), Gaps = 3/119 (2%) Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLH 614 + V + LS G I S +L L + I F L Sbjct: 36 ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP 95 Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRN 672 +L+ + +++NN+K+I +F+ L L L L N++ +P L +L + L N Sbjct: 96 HLEYLFIENNNIKSI-SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 153 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 42/114 (36%), Gaps = 2/114 (1%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 + ++ +L + EI + +L L + S + GL L+ L + Sbjct: 45 VPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE- 103 Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLE 604 +N+ + + L LS+ N + + + K + +LT ++L Sbjct: 104 -NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 156 >3ULU-A nrPDB Length = 694 Score = 100 bits (249), Expect = 3e-21, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 98/252 (38%), Gaps = 38/252 (15%) Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNL 616 KL QV D+ ++ L++ + + + + + L Sbjct: 25 KLTQVPDDLPTNITVLNLTHNQLRRLPAANFTR-----------------------YSQL 61 Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI-QIGNLTNLERLYLNRNKIE 675 +D+ N + +E + Q L L L L +N ++ + TNL L+L N I+ Sbjct: 62 TSLDVGFNTISKLEPELC-QKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQ 120 Query: 676 KIPTQLF-YCRKLRYLDLSHNNLTFLPADIGL-LQNLQNLAVTANRIEALPPE---LFQC 730 KI F + L LDLSHN L+ + L+NLQ L ++ N+I+AL E +F Sbjct: 121 KIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN 180 Query: 731 RKLRALHLGNNVLQSL-PSRVGELTNLTQIELRGNRL-------ECLPVELGECPLLKRS 782 L+ L L +N ++ P + L + L +L CL + L S Sbjct: 181 SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLS 240 Query: 783 GLVVEEDLFSTL 794 + +T Sbjct: 241 NSQLSTTSNTTF 252 Score = 95.6 bits (236), Expect = 9e-20, Method: Composition-based stats. Identities = 84/355 (23%), Positives = 151/355 (42%), Gaps = 33/355 (9%) Query: 445 LVELEVLKLELIPDVTI-PPSIAQLTGLKELWLYHTAAKIEAPALAFLR---------EN 494 L +LE LE + S+ L ++ L L + K + + + Sbjct: 281 LPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKC 340 Query: 495 LRALHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKR--LKVLRL 551 L L+++ DI I +++ L L+ L L+ S + R + + L L +L L Sbjct: 341 LEHLNMEDNDIPGIKSNMFTGLINLKYLSLS--NSFTSLRTLTNETFVSLAHSPLHILNL 398 Query: 552 KSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHS 609 N +SK+ HL+ L + NE + + + + N+ E+ L ++ + Sbjct: 399 TKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRN 458 Query: 610 IFSL-HNLQEIDLKDNNLKTIEEII-SFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLER 666 F+L +LQ + L+ LK ++ FQ L LT L L N+IA I + L LE Sbjct: 459 SFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEI 518 Query: 667 LYLNRNKIEKIPTQ---------LFYCRKLRYLDLSHNNLTFLPADI-GLLQNLQNLAVT 716 L L N + ++ L L L+L N +P ++ L L+ + + Sbjct: 519 LDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLG 578 Query: 717 ANRIEALPPELFQCR-KLRALHLGNNVLQSLPSRVGE--LTNLTQIELRGNRLEC 768 N + LP +F + L++L+L N++ S+ +V NLT++++R N +C Sbjct: 579 LNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDC 633 Score = 90.9 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 71/347 (20%), Positives = 131/347 (37%), Gaps = 36/347 (10%) Query: 444 DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFT 503 ++ + LKL +PD T + L L H + A L +L + F Sbjct: 17 EVADCSHLKLTQVPDDLP-------TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN 69 Query: 504 DIKEI-PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVV 562 I ++ P L L+ L+L + L L ++ +++ K+ Sbjct: 70 TISKLEPELCQKLPMLKVLNLQ-HNELSQLSDKTFAFCTNLTELHLM--SNSIQKIKNNP 126 Query: 563 TDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPH---SIFSLHNLQEI 619 +L L +++ G L + ++ NL EL L ++ + IF+ +L+++ Sbjct: 127 FVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKL 186 Query: 620 DLKDNNLKTIEEIISFQHLHRLTCL-----KLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674 +L N +K F + RL L +L + + +++ N T++ L L+ +++ Sbjct: 187 ELSSNQIKEFSP-GCFHAIGRLFGLFLNNVQLGPSLTEKLCLELAN-TSIRNLSLSNSQL 244 Query: 675 EKIPTQLFYC---RKLRYLDLSHNNLTFLPAD-IGLLQNLQNLAVTANRIEALPPELFQC 730 F L LDLS+NNL + D L L+ + N I+ L Sbjct: 245 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHG 304 Query: 731 -RKLRALHLGNN------VLQSLPS----RVGELTNLTQIELRGNRL 766 +R L+L + L SLP L L + + N + Sbjct: 305 LFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 351 Score = 86.7 bits (213), Expect = 4e-17, Method: Composition-based stats. Identities = 73/362 (20%), Positives = 136/362 (37%), Gaps = 42/362 (11%) Query: 469 TGLKELWLYHTAAKIEAPA--LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN 526 T ++ L L ++ + L NL L + + ++ + + L Sbjct: 232 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLN-----VVGNDSFAWLPQLEY 286 Query: 527 --LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV----------HLQKLSI 574 L N +++ L L ++ L LK + +K + + L+ L++ Sbjct: 287 FFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNM 346 Query: 575 NNEGTKLIVLNSLKKMVNLTELELIR--CDLERIPHSIF---SLHNLQEIDLKDNNLKTI 629 + I N ++NL L L L + + F + L ++L N + I Sbjct: 347 EDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKI 406 Query: 630 EEIISFQHLHRLTCLKLWYNHIAY--IPIQIGNLTNLERLYLNRNK-IEKIPTQLFYCRK 686 E +F L L L L N I + L N+ +YL+ NK ++ Sbjct: 407 ES-DAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 465 Query: 687 LRYLDLSH---NNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNV 742 L+ L L N+ P+ L+NL L ++ N I + ++ + KL L L +N Sbjct: 466 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 525 Query: 743 LQSLPSR---------VGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFST 793 L L + L++L + L N + +PVE+ + L + + + + +T Sbjct: 526 LARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFK-DLFELKIIDLGLNNLNT 584 Query: 794 LP 795 LP Sbjct: 585 LP 586 Score = 77.1 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 52/283 (18%), Positives = 94/283 (33%), Gaps = 20/283 (7%) Query: 462 PPSIAQLTG--LKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKE--IPLWIYSLKT 517 + L L L L +L L + +I + L+ Sbjct: 382 NETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLEN 441 Query: 518 LEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNE 577 + E++L+ + L+RL + R+ +L L ++N Sbjct: 442 IFEIYLS-YNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNN 500 Query: 578 GTKLIVLNSLKKMVNLTELELIRCDLERI---------PHSIFSLHNLQEIDLKDNNLKT 628 I + L+ + L L+L +L R+ + + L +L ++L+ N Sbjct: 501 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 560 Query: 629 IEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLNRNKIEKIPTQLFYC--R 685 I + F+ L L + L N++ +P N +L+ L L +N I + ++F R Sbjct: 561 I-PVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFR 619 Query: 686 KLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELF 728 L LD+ N I N N I L Sbjct: 620 NLTELDMRFNPFDCTCESIAWFVNWINET--HTNIPELSSHYL 660 >2XOT-A nrPDB Length = 361 Score = 99.0 bits (245), Expect = 7e-21, Method: Composition-based stats. Identities = 52/185 (28%), Positives = 82/185 (44%), Gaps = 16/185 (8%) Query: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP 655 L + L +P S+ S L +DL NNL + + L L L L +NH+ +I Sbjct: 23 LSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIS 80 Query: 656 IQ-IGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPAD-IGLLQNLQN 712 + + NL L L+ N + + LF + L L L +N++ + + + LQ Sbjct: 81 SEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQK 140 Query: 713 LAVTANRIEALPPELF----QCRKLRALHLGNNVLQSLPSRVGELTNL-----TQIELRG 763 L ++ N+I P EL + KL L L +N L+ LP + +L L + L Sbjct: 141 LYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLP--LTDLQKLPAWVKNGLYLHN 198 Query: 764 NRLEC 768 N LEC Sbjct: 199 NPLEC 203 Score = 77.8 bits (190), Expect = 2e-14, Method: Composition-based stats. Identities = 46/179 (25%), Positives = 74/179 (41%), Gaps = 33/179 (18%) Query: 553 SNLSKL-PQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF 611 +NLS+L + +L L +++ I + + NL L+ Sbjct: 49 NNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLD-------------- 94 Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-IGNLTNLERLYLN 670 L N+L T++E + F L L L L+ NHI + ++ L++LYL+ Sbjct: 95 ---------LSSNHLHTLDEFL-FSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLS 144 Query: 671 RNKIEKIPTQLF----YCRKLRYLDLSHNNLTFLP-ADIGLLQNL--QNLAVTANRIEA 722 +N+I + P +L KL LDLS N L LP D+ L L + N +E Sbjct: 145 QNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLEC 203 Score = 62.4 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 63/165 (38%), Gaps = 10/165 (6%) Query: 445 LVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTD 504 L++L L + P LT L L L H + NLR L + Sbjct: 43 LLDLSHNNLSRLRAEWTPTR---LTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNH 99 Query: 505 IKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTD 564 + + +++S E+ L N + + +L++L + + + +S+ P + Sbjct: 100 LHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQ--NQISRFPVELIK 157 Query: 565 VGVHLQK---LSINNEGTKLIVLNSLKKMVNLTE--LELIRCDLE 604 G L K L +++ K + L L+K+ + L L LE Sbjct: 158 DGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLE 202 Score = 62.4 bits (150), Expect = 8e-10, Method: Composition-based stats. Identities = 36/174 (20%), Positives = 63/174 (36%), Gaps = 20/174 (11%) Query: 491 LRENLRALHIKFTDIKEI-----PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545 L L + ++ + P + +L +L H N + + + Sbjct: 37 LPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISS-------EAFVPVPN 89 Query: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLE 604 L+ L L SN L L + + L+ L + N ++ N+ + M L +L L + + Sbjct: 90 LRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQIS 149 Query: 605 RIPHSI----FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC--LKLWYNHIA 652 R P + L L +DL N LK + + Q L L L N + Sbjct: 150 RFPVELIKDGNKLPKLMLLDLSSNKLKKL-PLTDLQKLPAWVKNGLYLHNNPLE 202 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 7/136 (5%) Query: 667 LYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIG--LLQNLQNLAVTANRIEALP 724 L ++ ++ +P L LDLSHNNL+ L A+ L NL +L ++ N + + Sbjct: 23 LSCSKQQLPNVPQSL--PSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIS 80 Query: 725 PELFQC-RKLRALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRLECLPVELGECPLLKRS 782 E F LR L L +N L +L + +L L + L N + + E + + Sbjct: 81 SEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFE-DMAQLQ 139 Query: 783 GLVVEEDLFSTLPPEV 798 L + ++ S P E+ Sbjct: 140 KLYLSQNQISRFPVEL 155 >2Z7X-B nrPDB Length = 520 Score = 98.6 bits (244), Expect = 1e-20, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 86/180 (47%), Gaps = 14/180 (7%) Query: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY-IPIQIGNLT 662 + + IFS N++ + + ++ + L N + + G+LT Sbjct: 292 QSYIYEIFSNMNIKNFTVSG---TRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLT 348 Query: 663 NLERLYLNRNKIE---KIPTQLFYCRKLRYLDLSHNNLTFL--PADIGLLQNLQNLAVTA 717 LE L L N+++ KI + L+ LD+S N++++ D ++L +L +++ Sbjct: 349 ELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSS 408 Query: 718 NRIEALPPELFQC--RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775 N L +F+C +++ L L +N ++S+P +V +L L ++ + N+L+ +P + + Sbjct: 409 N---ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIFD 465 Score = 54.3 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 64/182 (35%), Gaps = 14/182 (7%) Query: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554 L + + T E + + I + ++K L+ L + N Sbjct: 326 FLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIA-EMTTQMKSLQQLDISQN 384 Query: 555 LSKLPQVVTDVG--VHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFS 612 + D L L++++ + L + L+L ++ IP + Sbjct: 385 SVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP--PRIKVLDLHSNKIKSIPKQVVK 442 Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERL--YLN 670 L LQE+++ N LK++ + F L L + L N + ++ L +LN Sbjct: 443 LEALQELNVASNQLKSVPD-GIFDRLTSLQKIWLHTN------PWDCSCPRIDYLSRWLN 495 Query: 671 RN 672 +N Sbjct: 496 KN 497 Score = 46.6 bits (109), Expect = 5e-05, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 62/172 (36%), Gaps = 14/172 (8%) Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI--EAPALAFL 491 ML + F ++ L T+ + LT L+ L L K + + Sbjct: 317 MLCPSKISPFLHLDFSNNLLTD----TVFENCGHLTELETLILQMNQLKELSKIAEMTTQ 372 Query: 492 RENLRALHIKFTDIKEIPLW--IYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 ++L+ L I + K+L L+++ N+ + + R+KVL Sbjct: 373 MKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP------PRIKVL 426 Query: 550 RLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRC 601 L SN K LQ+L++ + K + ++ +L ++ L Sbjct: 427 DLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTN 478 Score = 45.1 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 46/111 (41%), Gaps = 3/111 (2%) Query: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCD 602 ++ +L + N +S+L L+ L I++ + + ++ K L L+L Sbjct: 21 QKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 80 Query: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653 L +I S NL+ +DL N + F ++ +L L L H+ Sbjct: 81 LVKI--SCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEK 129 Score = 32.4 bits (72), Expect = 0.73, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 31/69 (44%), Gaps = 1/69 (1%) Query: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPS-IAQLTGLKELWLYHTAAKIEAP 486 L+LH + IP V L L+ L + ++P +LT L+++WL+ P Sbjct: 426 LDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCP 485 Query: 487 ALAFLRENL 495 + +L L Sbjct: 486 RIDYLSRWL 494 >5GY2-A nrPDB Length = 455 Score = 90.6 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 56/312 (17%), Positives = 118/312 (37%), Gaps = 33/312 (10%) Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI--EAPALAFL 491 +LSG +E+ VL+ I + + L L K E L F Sbjct: 119 VLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQ 178 Query: 492 RENLRALHIKFTDIKEIPLWI---------YSLKTLEELHLTGNLSAENNRYIVIDGL-- 540 ++ L + ++++ + + ++ L L+GN E+ D + Sbjct: 179 GKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG 238 Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQ----------KLSINNEGTKLIVLNSLKKM 590 +++ L + + S + ++ ++ + Sbjct: 239 TKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHF 298 Query: 591 VNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN 649 +L +L L + ++ +I + F L +L +++L N L +I+ + F++L +L L L YN Sbjct: 299 TDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRM-FENLDKLEVLDLSYN 357 Query: 650 HIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLL 707 HI + L NL+ L L+ N+++ +P +F L+ + L N P D Sbjct: 358 HIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN-----PWDCSCP 412 Query: 708 Q-NLQNLAVTAN 718 + + + + N Sbjct: 413 RIDYLSRWLNKN 424 Score = 90.2 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 75/349 (21%), Positives = 113/349 (32%), Gaps = 66/349 (18%) Query: 445 LVELEVLKLELIPDVTIPPS---IAQLTGLKELWLYHTAAKIEAPALAFLR-ENLRALHI 500 L LEVL L S LT L+ L L K PA FL L + Sbjct: 102 LANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDL 161 Query: 501 KFTDIKEI---PLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 F +K I L + K L L+ + N Y L + + Sbjct: 162 TFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEY-------------WLGWEKCGN- 207 Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLN-SLKKM--VNLTELELIRC--------DLERI 606 + L ++ G K + + + L L Sbjct: 208 -----PFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFK 262 Query: 607 PHSIFSLHNLQEIDLKDNNLKTIEEIIS----FQHLHRLTCLKLWYNHIAYIPIQ-IGNL 661 F+ L+ +K +L + F H L L L N I I L Sbjct: 263 DPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGL 322 Query: 662 TNLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRI 720 T+L +L L++N + I +++F KL LDLS+N++ L Sbjct: 323 THLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGD------------------ 364 Query: 721 EALPPELFQCRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLEC 768 L+ L L N L+S+P + + LT+L +I L N +C Sbjct: 365 ----QSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDC 409 Score = 69.8 bits (169), Expect = 5e-12, Method: Composition-based stats. Identities = 59/333 (17%), Positives = 108/333 (32%), Gaps = 65/333 (19%) Query: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586 S L++L+ LKV + L + L L ++ + + Sbjct: 40 NSIAELNETSFSRLQDLQFLKVEQQTPGLV-IRNNTFRGLSSLIILKLDYNQFLQLETGA 98 Query: 587 LKKMVNLTELELIRCDLE-RIPHSIF--SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 + NL L L +C+L+ + F L +L+ + L+DNN+K I+ F ++ R Sbjct: 99 FNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHV 158 Query: 644 LKLWYNHIAYIPIQI---GNLTNLERLYLNRNKIEKIPT---------QLFYCRKLRYLD 691 L L +N + I + + L L+ ++ + F + LD Sbjct: 159 LDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLD 218 Query: 692 LSHNNLTFLPA---------------------DIGLL-------------------QNLQ 711 LS N A ++G ++ Sbjct: 219 LSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVK 278 Query: 712 NLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRLECL 769 ++ ++I AL +F L L L N + + LT+L ++ L N L + Sbjct: 279 TCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSI 338 Query: 770 -------PVELGECPLLKRSGLVVEEDLFSTLP 795 +L L + + F LP Sbjct: 339 DSRMFENLDKLEVLDLSYNHIRALGDQSFLGLP 371 >5D3I-A nrPDB Length = 568 Score = 90.2 bits (222), Expect = 4e-18, Method: Composition-based stats. Identities = 69/403 (17%), Positives = 143/403 (35%), Gaps = 54/403 (13%) Query: 445 LVELEVLKLELIPDVTI-PPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFT 503 L L L+++ + S+ + + L L+ + + A + ++R L ++ T Sbjct: 151 LTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDT 210 Query: 504 DIKEI---PLWIYSLKT-LEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN----- 554 ++ PL + + + +++L G++ + + ++ LR + L + Sbjct: 211 NLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGL 270 Query: 555 -------------LSKLPQVVTDVGVHLQ------------------KLSINNEGTKLIV 583 L K+ V Q ++++ N L+ Sbjct: 271 GDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVP 330 Query: 584 LNSLKKMVNLTELELIRC----DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIIS-FQHL 638 + + + +L L+L + + + +LQ + L N+L+++++ L Sbjct: 331 CSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTL 390 Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698 LT L + N +P + L L+ I + T + + L LD+S+NNL Sbjct: 391 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCI--PQTLEVLDVSNNNLD 448 Query: 699 FLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 L LQ L ++ N+++ LP L N V ++G L Sbjct: 449 SFSL---FLPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLET 505 Query: 759 IELRGNRLECLPVELG---ECPLLKRSGLVVEEDLFSTLPPEV 798 +E N C L E P L + + + PP + Sbjct: 506 LEAGDNHFVCSCELLSFTMETPALAQILVDWPDSYLCDSPPRL 548 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Query: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAVTANRIEALPPELFQC-RK 732 IP+ L ++ LDLS N +T++ D+ NLQ L + ++RI + + F Sbjct: 22 TSIPSGL--TAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 79 Query: 733 LRALHLGNNVLQSLPSR-VGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 L L L +N L SL S G L++L + L GN + L V L L + Sbjct: 80 LEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRI 134 Score = 57.0 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 67/160 (41%), Gaps = 14/160 (8%) Query: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLE 604 +K L L N ++ + +LQ L + + I ++ + +L L+L L Sbjct: 32 MKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLS 91 Query: 605 RIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY----NHIAYIPIQIG 659 + S F L +L+ ++L N +T+ F +L L L++ + I I Sbjct: 92 SLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRID--FA 149 Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYL-DLSHNNLT 698 LT+L L +I+ + + + + L+ + D+ H L Sbjct: 150 GLTSLNEL-----EIKALSLRNYQSQSLKSIRDIHHLTLH 184 Score = 53.6 bits (127), Expect = 4e-07, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 7/119 (5%) Query: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFLPAD-IGLL 707 IP + ++ L L+ NKI I L C L+ L L + + + D L Sbjct: 20 SFTSIPSGLT--AAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 77 Query: 708 QNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSL--PSRVGELTNLTQIELRG 763 +L++L ++ N + +L F L+ L+L N Q+L S LTNL + + Sbjct: 78 GSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGN 136 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 42/99 (42%), Gaps = 3/99 (3%) Query: 698 TFLPADIGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVG-ELTN 755 +F GL +++L ++ N+I + + C L+ L L ++ + ++ L + Sbjct: 20 SFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 79 Query: 756 LTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTL 794 L ++L N L L PL L + + + TL Sbjct: 80 LEHLDLSDNHLSSLSSSWFG-PLSSLKYLNLMGNPYQTL 117 >3V44-A nrPDB Length = 407 Score = 89.0 bits (219), Expect = 8e-18, Method: Composition-based stats. Identities = 57/337 (16%), Positives = 106/337 (31%), Gaps = 58/337 (17%) Query: 489 AFLRENLRALHIKFTDIKEIPLWIYS--------------------------LKTLEELH 522 L ++ + + I E+ +S L +L L Sbjct: 26 PELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILK 85 Query: 523 LTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLI 582 L +GL L+ L + + + + L L+ L + + K I Sbjct: 86 L-DYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKI 144 Query: 583 -VLNSLKKMVNLTELELIRCDLERIPHS---IFSLHNLQEIDLKDNNLKTIEEI------ 632 + M L+L ++ I F + + L L+ + E Sbjct: 145 QPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEK 204 Query: 633 -ISFQHLHRLTCLKLWYNHIAY-IPIQIGNL---TNLERLYLNR--NKIEKIPTQLFYCR 685 + +T L L N + + + T ++ L L+ N F Sbjct: 205 CGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDP 264 Query: 686 -----------KLRYLDLSHNNLTFLPADI-GLLQNLQNLAVTANRIEALPPELFQC-RK 732 ++ DLS + + L + +L+ L + N I + F Sbjct: 265 DNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTH 324 Query: 733 LRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLEC 768 L+ L L N L+S+P + + LT+L +I L N +C Sbjct: 325 LKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDC 361 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 57/308 (18%), Positives = 103/308 (33%), Gaps = 41/308 (13%) Query: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586 S L++L+ LKV + L + L L ++ + + Sbjct: 40 NSIAELNETSFSRLQDLQFLKVEQQTPGLV-IRNNTFRGLSSLIILKLDYNQFLQLETGA 98 Query: 587 LKKMVNLTELELIRCDLE-RIPHSIF--SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 + NL L L +C+L+ + F L +L+ + L+DNN+K I+ F ++ R Sbjct: 99 FNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHV 158 Query: 644 LKLWYNHIAYIPIQI---GNLTNLERLYLNRNKIEKIPT---------QLFYCRKLRYLD 691 L L +N + I + + L L+ ++ + F + LD Sbjct: 159 LDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLD 218 Query: 692 LSHNNLTFLPAD------IGLLQNLQNLAVTANRIEALPPELFQ-----------CRKLR 734 LS N A G L+ + N + F+ ++ Sbjct: 219 LSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVK 278 Query: 735 ALHLGNNVLQSLPSRVG-ELTNLTQIELRGNRLECLPVE-------LGECPLLKRSGLVV 786 L + + +L V T+L Q+ L N + + L E L V Sbjct: 279 TCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSV 338 Query: 787 EEDLFSTL 794 + +F L Sbjct: 339 PDGIFDRL 346 Score = 64.4 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 96/254 (37%), Gaps = 30/254 (11%) Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKI--EAPALAFL 491 +LSG +E+ VL+ I + + L L K E L F Sbjct: 119 VLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQ 178 Query: 492 RENLRALHIKFTDIKEIPLWI---------YSLKTLEELHLTGNLSAENNRYIVIDGLRE 542 ++ L + ++++ + + ++ L L+GN E+ D + Sbjct: 179 GKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG 238 Query: 543 LKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMV--NLTELELIR 600 +++ L L ++ + S + K + K + + +L + Sbjct: 239 -TKIQSLILSNSYN-------------MGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSK 284 Query: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ-I 658 + + S+FS +L+++ L N + I++ +F L L L L N + +P Sbjct: 285 SKIFALLKSVFSHFTDLEQLTLAQNEINKIDD-NAFWGLTHLKELALDTNQLKSVPDGIF 343 Query: 659 GNLTNLERLYLNRN 672 LT+L++++L+ N Sbjct: 344 DRLTSLQKIWLHTN 357 >3A79-B nrPDB Length = 562 Score = 88.6 bits (218), Expect = 1e-17, Method: Composition-based stats. Identities = 77/438 (17%), Positives = 148/438 (33%), Gaps = 69/438 (15%) Query: 397 VSENKLRQLNLNNEWTLDKLR-QRLTKNAQDKLELHLFM--------------LSGIPDT 441 +S+N + +L + + L +LR RL+ N L+ H+F+ L I Sbjct: 59 LSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCC 118 Query: 442 VFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYH-TAAKIEAPALAFLRENLRALHI 500 + L + + LT L L L +++ +A L + L + Sbjct: 119 PMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDL 178 Query: 501 KFTDIK--EIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKL 558 IK E T+ L N + ++ L L+ + N +L Sbjct: 179 VSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRL 238 Query: 559 PQVVTDVGVHLQKLSINNE-------------GTKLIVLNSLKKMVNLT----------- 594 ++++ L++ + + NLT Sbjct: 239 MTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFT 298 Query: 595 -------ELELIR--CDL----ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641 L + + + +S+F+ N++ + + D + S Sbjct: 299 YSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSS---F 355 Query: 642 TCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRK---LRYLDLSHNNL 697 T L N + L L+ L L RN ++ + L LD+S N+L Sbjct: 356 TFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSL 415 Query: 698 TFLPAD--IGLLQNLQNLAVTANRIEALPPELFQC--RKLRALHLGNNVLQSLPSRVGEL 753 D +++ L +++N L +F+C K++ L L NN + S+P V L Sbjct: 416 NSHAYDRTCAWAESILVLNLSSN---MLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHL 472 Query: 754 TNLTQIELRGNRLECLPV 771 L ++ + N+L+ +P Sbjct: 473 QALQELNVASNQLKSVPD 490 Score = 76.3 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 592 NLTELELIRCDLER-IPHSIFSLHNLQEIDLKDNNL-KTIEEIISFQHLHRLTCLKLWYN 649 + T L + + +L LQ + L+ N L + + +++ L L + N Sbjct: 354 SFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLN 413 Query: 650 HIA--YIPIQIGNLTNLERLYLNRNKIEKIPTQLFY--CRKLRYLDLSHNNLTFLPADIG 705 + ++ L L+ N + +F K++ LDL +N + +P D+ Sbjct: 414 SLNSHAYDRTCAWAESILVLNLSSNMLTG---SVFRCLPPKVKVLDLHNNRIMSIPKDVT 470 Query: 706 LLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNR 765 LQ LQ L V +N+++++P +F LT+L I L N Sbjct: 471 HLQALQELNVASNQLKSVPDGVFD----------------------RLTSLQYIWLHDNP 508 Query: 766 LEC 768 +C Sbjct: 509 WDC 511 Score = 59.4 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 50/242 (20%), Positives = 91/242 (37%), Gaps = 37/242 (15%) Query: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER 605 L+ + SN + L V D+ + LS++ + + + + L L L + Sbjct: 32 LESMVDYSNRN-LTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRS 90 Query: 606 IPHSIFSLHN-LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI--QIGNLT 662 + +F + L+ +D+ N L+ I + L L L +N +P+ + GNLT Sbjct: 91 LDFHVFLFNQDLEYLDVSHNRLQNISCCP----MASLRHLDLSFNDFDVLPVCKEFGNLT 146 Query: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEA 722 L L L+ R+L L ++H +L+ + L + + I+ Sbjct: 147 KLTFLGLS----------AAKFRQLDLLPVAHLHLSCIL-----------LDLVSYHIKG 185 Query: 723 LPPELFQ--CRKLRALHLGNNVLQSLP-----SRVGELTNLTQIELRGNRLECLPVELGE 775 E Q + L N L S+ + +G L L+ I+L + L L E Sbjct: 186 GETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQ-LSNIKLNDENCQRLMTFLSE 244 Query: 776 CP 777 Sbjct: 245 LT 246 Score = 43.2 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 25/137 (18%), Positives = 44/137 (32%), Gaps = 6/137 (4%) Query: 467 QLTGLKELWLYHTAAK--IEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLT 524 L L+ L L K + + +L L + + L L Sbjct: 375 TLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVL- 433 Query: 525 GNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVL 584 NLS+ V L ++KVL L +N LQ+L++ + K + Sbjct: 434 -NLSSNMLTGSVFRCLP--PKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPD 490 Query: 585 NSLKKMVNLTELELIRC 601 ++ +L + L Sbjct: 491 GVFDRLTSLQYIWLHDN 507 >2Z7X-A nrPDB Length = 549 Score = 83.6 bits (205), Expect = 3e-16, Method: Composition-based stats. Identities = 56/283 (19%), Positives = 116/283 (40%), Gaps = 16/283 (5%) Query: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 E+L + I + + TL + GN A +N ++ G E ++ L + Sbjct: 238 ESLFQVMKLLNQISGLLELEFDDCTLNGV---GNFRASDNDRVIDPGKVETLTIRRLHIP 294 Query: 553 S-NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRC----DLERIP 607 L + + ++++++ N L+ + + +L L+L + + Sbjct: 295 RFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNS 354 Query: 608 HSIFSLHNLQEIDLKDNNLKTIEEII-SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLER 666 + +LQ + L+ N+L ++E+ + L LT + + N +P ++ Sbjct: 355 ACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKY 414 Query: 667 LYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPE 726 L L+ +I + + + L LD+S+ L L L+ L ++ N++ LP Sbjct: 415 LNLSSTRIHSVTGCI--PKTLEILDVSN---NNLNLFSLNLPQLKELYISRNKLMTLPD- 468 Query: 727 LFQCRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLEC 768 L L + N L+S+P + + LT+L +I L N +C Sbjct: 469 ASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTNPWDC 511 Score = 62.8 bits (151), Expect = 6e-10, Method: Composition-based stats. Identities = 49/255 (19%), Positives = 102/255 (40%), Gaps = 15/255 (5%) Query: 544 KRLKVLRLKSNLSKLPQVVT-DVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCD 602 + +K L L +N V+LQ L + + G I +S + +L L+L Sbjct: 26 EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY 85 Query: 603 LERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY-NHIAYIPI-QIG 659 L + S F L +L ++L N KT+ E F HL +L L++ + I Sbjct: 86 LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFA 145 Query: 660 NLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLS-HNNLTFLPADIGLLQNLQNLAVTA 717 LT LE L ++ + ++ P L + + +L L ++ L + + +++ L + Sbjct: 146 GLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRD 205 Query: 718 NRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRG--NRLECLPV-ELG 774 ++ + N++++ R ++T+ + ++ N++ L E Sbjct: 206 TDLDTFHFSELSTGE------TNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFD 259 Query: 775 ECPLLKRSGLVVEED 789 +C L ++ Sbjct: 260 DCTLNGVGNFRASDN 274 Score = 57.4 bits (137), Expect = 3e-08, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 51/122 (41%), Gaps = 7/122 (5%) Query: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFLPAD-I 704 + IP + ++ L L+ N+I I + L C L+ L L+ N + + D Sbjct: 13 SSGSLNSIPSGLT--EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 70 Query: 705 GLLQNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSLPSR--VGELTNLTQIEL 761 L +L++L ++ N + L F+ L L+L N ++L LT L + + Sbjct: 71 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 130 Query: 762 RG 763 Sbjct: 131 GN 132 >2Z80-A nrPDB Length = 353 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 101/264 (38%), Gaps = 39/264 (14%) Query: 544 KRLKVLRLKSNLSKLPQVVT-DVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCD 602 + +K L L +N V+LQ L + + G I +S + +L L+L Sbjct: 52 EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY 111 Query: 603 LERIPHSIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY-NHIAYIPI-QIG 659 L + S F L +L ++L N KT+ E F HL +L L++ + I Sbjct: 112 LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFA 171 Query: 660 NLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLS-HNNLTFLPADIGLLQNLQNLAVTA 717 LT LE L ++ + ++ P L + + +L L ++ L + + +++ L + Sbjct: 172 GLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRD 231 Query: 718 NRIEA--------------LPPELFQC------------------RKLRALHLGNNVLQS 745 ++ + F+ L L N L+S Sbjct: 232 TDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFSRNQLKS 291 Query: 746 LPSRVGE-LTNLTQIELRGNRLEC 768 +P + + LT+L +I L N +C Sbjct: 292 VPDGIFDRLTSLQKIWLHTNPWDC 315 Score = 60.9 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 5/120 (4%) Query: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP-ADIGLLQNLQNLAVTANRIEALPPELF 728 + + IP+ L ++ LDLS+N +T++ +D+ NLQ L +T+N I + + F Sbjct: 39 SSGSLNSIPSGL--TEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 96 Query: 729 QC-RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786 L L L N L +L S + L++LT + L GN + L L K L V Sbjct: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156 Score = 57.8 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 51/122 (41%), Gaps = 7/122 (5%) Query: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTFLPAD-I 704 + IP + ++ L L+ N+I I + L C L+ L L+ N + + D Sbjct: 39 SSGSLNSIPSGLT--EAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 96 Query: 705 GLLQNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVLQSLPSR--VGELTNLTQIEL 761 L +L++L ++ N + L F+ L L+L N ++L LT L + + Sbjct: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156 Query: 762 RG 763 Sbjct: 157 GN 158 >3CVR-A nrPDB Length = 571 Score = 79.8 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 26/205 (12%) Query: 569 LQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLH-NLQEIDLKDNNLK 627 +L +N + N +T LE+ + L +P L +L+ +D DN L Sbjct: 61 FSELQLNRLNLSSLPDNL---PPQITVLEITQNALISLPE----LPASLEYLDACDNRLS 113 Query: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKL 687 T+ E+ + L L + N + +P LE + + N++ +P L Sbjct: 114 TLPELPA-----SLKHLDVDNNQLTMLPE---LPALLEYINADNNQLTMLPE---LPTSL 162 Query: 688 RYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALP----PELFQCRKLRALHLGNNVL 743 L + +N LTFLP L ++L+ L V+ N +E+LP N + Sbjct: 163 EVLSVRNNQLTFLPE---LPESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRI 219 Query: 744 QSLPSRVGELTNLTQIELRGNRLEC 768 +P + L I L N L Sbjct: 220 THIPENILSLDPTCTIILEDNPLSS 244 Score = 63.2 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 38/154 (24%), Positives = 57/154 (37%), Gaps = 30/154 (19%) Query: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTAN 718 + L LNR + +P L ++ L+++ N L LP L +L+ L N Sbjct: 56 CLINQFSELQLNRLNLSSLPDNL--PPQITVLEITQNALISLPE---LPASLEYLDACDN 110 Query: 719 RIEALPPELFQCRKLRALHLGNNVLQSLPSRVGEL-----------------TNLTQIEL 761 R+ LP L+ L + NN L LP L T+L + + Sbjct: 111 RLSTLPE---LPASLKHLDVDNNQLTMLPELPALLEYINADNNQLTMLPELPTSLEVLSV 167 Query: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFSTLP 795 R N+L LP L V +L +LP Sbjct: 168 RNNQLTFLPELPESLEAL-----DVSTNLLESLP 196 Score = 35.1 bits (79), Expect = 0.14, Method: Composition-based stats. Identities = 21/156 (13%), Positives = 56/156 (35%), Gaps = 18/156 (11%) Query: 435 LSGIPDTVFDL--VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLR 492 LS +P+ L ++++ +L ++P++ + L L Sbjct: 112 LSTLPELPASLKHLDVDNNQLTMLPELPALLEYINADNNQLTML------------PELP 159 Query: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 +L L ++ + +P ++LE L ++ NL V + E + + Sbjct: 160 TSLEVLSVRNNQLTFLPE---LPESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRE 216 Query: 553 SNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 + ++ +P+ + + + + + + SL Sbjct: 217 NRITHIPENILSLDPTC-TIILEDNPLSSRIRESLS 251 >1M9S-A nrPDB Length = 605 Score = 75.1 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 52/191 (27%), Positives = 83/191 (43%), Gaps = 10/191 (5%) Query: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII 633 I + + + ++ + N+T+L L L I + +L NL + L +N +K + + Sbjct: 48 IIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDI-KPLTNLKNLGWLFLDENKIKDLSSLK 106 Query: 634 SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLS 693 + L L+ +N I+ I + +L LE LYL NKI I T L KL L L Sbjct: 107 DLKKLKSLSL---EHNGISDI-NGLVHLPQLESLYLGNNKITDI-TVLSRLTKLDTLSLE 161 Query: 694 HNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGEL 753 N ++ + GL + LQNL ++ N I L L + L L L + L + Sbjct: 162 DNQISDIVPLAGLTK-LQNLYLSKNHISDL-RALAGLKNLDVLELFSQEC--LNKPINHQ 217 Query: 754 TNLTQIELRGN 764 +NL N Sbjct: 218 SNLVVPNTVKN 228 Score = 65.9 bits (159), Expect = 7e-11, Method: Composition-based stats. Identities = 43/199 (21%), Positives = 75/199 (37%), Gaps = 26/199 (13%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRAL 498 PD F + LK + + D L + ++ ++ K N+ L Sbjct: 16 PDDAFAETIKDNLKKKSVTDAVTQNE---LNSIDQIIANNSDIKSVQGIQYL--PNVTKL 70 Query: 499 HIKFTDIKEIPLWIYSLKTLEELHLTGN----------------LSAENNRYIVIDGLRE 542 + + +I + +LK L L L N LS E+N I+GL Sbjct: 71 FLNGNKLTDIK-PLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVH 129 Query: 543 LKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCD 602 L +L+ L L +N V++ + L LS+ + IV L + L L L + Sbjct: 130 LPQLESLYLGNNKITDITVLSRL-TKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSKNH 186 Query: 603 LERIPHSIFSLHNLQEIDL 621 + + ++ L NL ++L Sbjct: 187 ISDL-RALAGLKNLDVLEL 204 Score = 47.4 bits (111), Expect = 3e-05, Method: Composition-based stats. Identities = 33/156 (21%), Positives = 62/156 (39%), Gaps = 29/156 (18%) Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAV----- 715 L +++++ N + I+ + + Y + L L+ N LT + L+NL L + Sbjct: 42 LNSIDQIIANNSDIKSVQ-GIQYLPNVTKLFLNGNKLTDIKPLTN-LKNLGWLFLDENKI 99 Query: 716 -----------------TANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 N I + L +L +L+LGNN + + + + LT L Sbjct: 100 KDLSSLKDLKKLKSLSLEHNGISDI-NGLVHLPQLESLYLGNNKITDI-TVLSRLTKLDT 157 Query: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTL 794 + L N++ + G L K L + ++ S L Sbjct: 158 LSLEDNQISDIVPLAG---LTKLQNLYLSKNHISDL 190 >5KH1-A nrPDB Length = 591 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 77/217 (35%), Gaps = 40/217 (18%) Query: 570 QKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLH-NLQEIDLKDNNLKT 628 L ++ G + + + + + +L I L +L ++++ N L Sbjct: 70 TNLDLSELGLTTLPEIP----PGIKSINISKNNLSLIS----PLPASLTQLNVSYNRLIE 121 Query: 629 IEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLR 688 + + L L +N + +P +L+ L+++ N++ +P L Sbjct: 122 LPALP-----QGLKLLNASHNQLITLP---TLPISLKELHVSNNQLCSLPV---LPELLE 170 Query: 689 YLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALH----------- 737 LD+S N L LP L +LQ ++ N + LPP + A+ Sbjct: 171 TLDVSCNGLAVLPP---LPFSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPE 227 Query: 738 ------LGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 N + +P + L N I++ N L Sbjct: 228 NLRNGYFDINQISHIPESILNLRNECSIDISDNPLSS 264 Score = 65.1 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 103/273 (37%), Gaps = 36/273 (13%) Query: 444 DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFT 503 E + +++ + +E L +++ L + +++++I Sbjct: 40 HWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNL--DLSELGLTTLPEIPPGIKSINISKN 97 Query: 504 DIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVT 563 ++ I +L +L++ NR I + L + LK+L N + Sbjct: 98 NLSLIS---PLPASLTQLNV------SYNRLIELPALPQ--GLKLLNASHNQLIT---LP 143 Query: 564 DVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKD 623 + + L++L ++N + L ++ L L++ L +P FS LQEI Sbjct: 144 TLPISLKELHVSNNQLCSLP--VLPEL--LETLDVSCNGLAVLPPLPFS---LQEISAIG 196 Query: 624 NNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFY 683 N L + + H + + N + IP NL Y + N+I IP + Sbjct: 197 NLLSELPPLP-----HNIHSIWAIDNMLTDIP---YLPENLRNGYFDINQISHIPESILN 248 Query: 684 CRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVT 716 R +D+S N L+ LQ+LQ L + Sbjct: 249 LRNECSIDISDNPLSS-----HALQSLQRLTSS 276 Score = 62.4 bits (150), Expect = 8e-10, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 105/305 (34%), Gaps = 51/305 (16%) Query: 385 LYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLR--------QRLT---KNAQDKLELHLF 433 L S F+ + + S L EW ++++ QRL +N + L+L Sbjct: 18 LISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNLDLSEL 77 Query: 434 MLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLT--------------GLKELWLYHT 479 L+ +P+ + + + K L +P S+ QL GLK L H Sbjct: 78 GLTTLPEIPPGIKSINISKNNLSLISPLPASLTQLNVSYNRLIELPALPQGLKLLNASHN 137 Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539 L L +L+ LH+ + +P+ L+TL N V+ Sbjct: 138 QLI----TLPTLPISLKELHVSNNQLCSLPVLPELLETL---------DVSCNGLAVLPP 184 Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELI 599 L L+ S + L + + ++ + + I NL Sbjct: 185 LP-----FSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLP----ENLRNGYFD 235 Query: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659 + IP SI +L N ID+ DN L + + Q L RLT ++ Y + G Sbjct: 236 INQISHIPESILNLRNECSIDISDNPLSS----HALQSLQRLTSSPDYHGPQIYFSMSDG 291 Query: 660 NLTNL 664 L Sbjct: 292 QQNTL 296 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 43/199 (21%), Positives = 75/199 (37%), Gaps = 28/199 (14%) Query: 605 RIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI------ 658 + H L ++ T + +L T K N I I Sbjct: 7 EFMLPTNNNHRLISNSFSTYSIDTSRAYEN--YLTHWTEWK--NNRIQEEQRDIAFQRLV 62 Query: 659 -GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTA 717 L L+ + +P ++ +++S NNL+ + L +L L V+ Sbjct: 63 SCLQNQETNLDLSELGLTTLPE---IPPGIKSINISKNNLSLISP---LPASLTQLNVSY 116 Query: 718 NRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECP 777 NR+ LP + L+ L+ +N L +LP+ +L ++ + N+L LPV P Sbjct: 117 NRLIELPA---LPQGLKLLNASHNQLITLPTLPI---SLKELHVSNNQLCSLPV----LP 166 Query: 778 LLKRSGLVVEEDLFSTLPP 796 L + L V + + LPP Sbjct: 167 ELLET-LDVSCNGLAVLPP 184 >2V9T-B nrPDB Length = 220 Score = 73.6 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 36/147 (24%), Positives = 58/147 (39%), Gaps = 30/147 (20%) Query: 650 HIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNLTFL-PADIGLL 707 + IP + + + L +N I+ IP F +KLR +DLS+N ++ L P L Sbjct: 22 GLTEIPTNL--PETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGL 79 Query: 708 QNLQNLAVTANRIEALPPELFQCR-------------------------KLRALHLGNNV 742 ++L +L + N+I LP LF+ L L L +N Sbjct: 80 RSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNK 139 Query: 743 LQSLPSR-VGELTNLTQIELRGNRLEC 768 LQ++ L + + L N C Sbjct: 140 LQTIAKGTFSPLRAIQTMHLAQNPFIC 166 Score = 63.2 bits (152), Expect = 5e-10, Method: Composition-based stats. Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 5/137 (3%) Query: 491 LRENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 L E + + ++ IK IP +S K L + L+ N GLR L L + Sbjct: 30 LPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS-NNQISELAPDAFQGLRSLNSLVL- 87 Query: 550 RLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHS 609 + +++LP+ + + LQ L +N + +++ + + NL L L L+ I Sbjct: 88 -YGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKG 146 Query: 610 IFS-LHNLQEIDLKDNN 625 FS L +Q + L N Sbjct: 147 TFSPLRAIQTMHLAQNP 163 Score = 56.3 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 5/102 (4%) Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLL-QNLQNLAVTANRIEALPPELFQC-R 731 + +IPT L + + L N + +P + L+ + ++ N+I L P+ FQ R Sbjct: 23 LTEIPTNL--PETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLR 80 Query: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRG-NRLECLPVE 772 L +L L N + LP + E Q+ L N++ CL V+ Sbjct: 81 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 122 Score = 46.3 bits (108), Expect = 6e-05, Method: Composition-based stats. Identities = 28/181 (15%), Positives = 56/181 (30%), Gaps = 34/181 (18%) Query: 436 SGIPDTVFDLVE-LEVLKLELIPDVTIPP-SIAQLTGLKELWLYHTAAKIEAPALAFLRE 493 G+ + +L E + ++LE IPP + + L+ + L + AP Sbjct: 21 KGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLR 80 Query: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553 +L +L + I E+P ++ +L L R L Sbjct: 81 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDL------------- 127 Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELI------RCDLERIP 607 +L LS+ + + I + + + + L C L+ + Sbjct: 128 -------------HNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLA 174 Query: 608 H 608 Sbjct: 175 D 175 >4AY9-X nrPDB Length = 350 Score = 70.9 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 10/187 (5%) Query: 569 LQKLSINNEGTKLIVL-NSLKKMVNLTELELIR-CDLERIPHSIF-SLHNLQEIDLKDNN 625 L+K+ I+ ++ + + L E+ + + +L I F +L NLQ + + + Sbjct: 56 LEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTG 115 Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLER--LYLNRNKIEKIPTQLFY 683 +K + ++ L ++ +I I + E L+LN+N I++I F Sbjct: 116 IKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFN 175 Query: 684 CRKLRYLDLS-HNNLTFLPADI-GLLQNLQNLAVTANRIEALPP-ELFQCRKLRALHLGN 740 +L L+LS +NNL LP D+ L ++ RI +LP L +KLRA N Sbjct: 176 GTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYN 235 Query: 741 NVLQSLP 747 L+ LP Sbjct: 236 --LKKLP 240 Score = 56.3 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 48/217 (22%), Positives = 88/217 (40%), Gaps = 31/217 (14%) Query: 491 LRENLRALHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 L N L T ++ I +S LE++ ++ N E V L +L +++ Sbjct: 28 LPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIE 87 Query: 550 RLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIV----LNSLKKM-------VNLTELE- 597 + + L P+ ++ +LQ L I+N G K + ++SL+K+ +N+ +E Sbjct: 88 KANNLLYINPEAFQNLP-NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIER 146 Query: 598 --------------LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 L + ++ I +S F+ L E++L DNN F Sbjct: 147 NSFVGLSFESVILWLNKNGIQEIHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVI 206 Query: 644 LKLWYNHIAYIPIQIGNLTNLERLYLNRN-KIEKIPT 679 L + I +P L NL++L ++K+PT Sbjct: 207 LDISRTRIHSLPS--YGLENLKKLRARSTYNLKKLPT 241 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 35/222 (15%), Positives = 66/222 (29%), Gaps = 47/222 (21%) Query: 452 KLELIPDVTI-------PPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTD 504 KL I P + L NL+ L I T Sbjct: 80 KLHEIRIEKANNLLYINPEAFQNL------------------------PNLQYLLISNTG 115 Query: 505 IKEIPLWIYSLKTLEE--LHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVV 562 IK +P ++ + +L++ L + N++ GL + L N + Sbjct: 116 IKHLPD-VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWL--NKNGIQEIHNS 172 Query: 563 TDVGVHLQKLSI-NNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDL 621 G L +L++ +N + + + L++ R + +P + L NL+++ Sbjct: 173 AFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPS--YGLENLKKL-- 228 Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663 + + L L L P N Sbjct: 229 ------RARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFAN 264 Score = 30.8 bits (68), Expect = 2.5, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 42/104 (40%), Gaps = 7/104 (6%) Query: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPAD-IGLLQNLQNLAVTANRI-EALPPELF-Q 729 K+ +IP+ L R L L + +L+ + ++ N + E + ++F Sbjct: 20 KVTEIPSDL--PRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSN 77 Query: 730 CRKLRALHL--GNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771 KL + + NN+L P L NL + + ++ LP Sbjct: 78 LPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 >1XWD-C nrPDB Length = 252 Score = 67.8 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 10/187 (5%) Query: 569 LQKLSINNEGTKLIVL-NSLKKMVNLTELELIR-CDLERIPHSIF-SLHNLQEIDLKDNN 625 L+K+ I+ ++ + + L E+ + + +L I F +L NLQ + + + Sbjct: 56 LEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTG 115 Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLER--LYLNRNKIEKIPTQLFY 683 +K + ++ L ++ +I I + E L+LN+N I++I F Sbjct: 116 IKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFN 175 Query: 684 CRKLRYLDLS-HNNLTFLPADI-GLLQNLQNLAVTANRIEALPP-ELFQCRKLRALHLGN 740 +L L+LS +NNL LP D+ L ++ RI +LP L +KLRA N Sbjct: 176 GTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYN 235 Query: 741 NVLQSLP 747 L+ LP Sbjct: 236 --LKKLP 240 Score = 52.8 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 87/217 (40%), Gaps = 31/217 (14%) Query: 491 LRENLRALHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 L N L T ++ I +S LE++ ++ N E V L +L +++ Sbjct: 28 LPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIE 87 Query: 550 RLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIV----LNSLKKM-------VNLTELE- 597 + + L P+ ++ +LQ L I+N G K + ++SL+K+ +N+ +E Sbjct: 88 KANNLLYINPEAFQNLP-NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIER 146 Query: 598 --------------LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 L + ++ I + F+ L E++L DNN F Sbjct: 147 NSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVI 206 Query: 644 LKLWYNHIAYIPIQIGNLTNLERLYLNRN-KIEKIPT 679 L + I +P L NL++L ++K+PT Sbjct: 207 LDISRTRIHSLPS--YGLENLKKLRARSTYNLKKLPT 241 Score = 39.7 bits (91), Expect = 0.006, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 63/181 (34%), Gaps = 33/181 (18%) Query: 462 PPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE- 520 P + L NL+ L I T IK +P ++ + +L++ Sbjct: 97 PEAFQNL------------------------PNLQYLLISNTGIKHLPD-VHKIHSLQKV 131 Query: 521 -LHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSI-NNEG 578 L + N++ GL + L N + G L +L++ +N Sbjct: 132 LLDIQDNINIHTIERNSFVGLSFESVILWL--NKNGIQEIHNCAFNGTQLDELNLSDNNN 189 Query: 579 TKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDN-NLKTIEEIISFQH 637 + + + L++ R + +P + L NL+++ + NLK + + Sbjct: 190 LEELPNDVFHGASGPVILDISRTRIHSLPS--YGLENLKKLRARSTYNLKKLPTLEKLVA 247 Query: 638 L 638 L Sbjct: 248 L 248 Score = 30.1 bits (66), Expect = 4.2, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 42/104 (40%), Gaps = 7/104 (6%) Query: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPAD-IGLLQNLQNLAVTANRI-EALPPELF-Q 729 K+ +IP+ L R L L + +L+ + ++ N + E + ++F Sbjct: 20 KVTEIPSDL--PRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSN 77 Query: 730 CRKLRALHL--GNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771 KL + + NN+L P L NL + + ++ LP Sbjct: 78 LPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 >5YXM-A nrPDB Length = 203 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 6/120 (5%) Query: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662 +E++ ++ +L + + L NN++ I S + L L L N I I Sbjct: 42 IEKMDATLSTLKACKHLALSTNNIEKI---SSLSGMENLRILSLGRNLIKKIENLDAVAD 98 Query: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT--FLPADIGLLQNLQNLAVTANRI 720 LE L+++ N+I + + + LR L +S+N +T + L L++L + N + Sbjct: 99 TLEELWISYNQIASL-SGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPL 157 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 4/113 (3%) Query: 516 KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSIN 575 TL L +L+ N I L ++ L++L L NL K + + V L++L I+ Sbjct: 47 ATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVADTLEELWIS 106 Query: 576 NEGTKLIVLNSLKKMVNLTELELIRCDLERIPH--SIFSLHNLQEIDLKDNNL 626 L+ ++K+VNL L + + + +L L+++ L N L Sbjct: 107 YNQIAS--LSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPL 157 Score = 49.3 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 56/127 (44%), Gaps = 8/127 (6%) Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKL 733 IEK+ L + ++L LS NN+ + + ++NL+ L++ N I+ + L Sbjct: 42 IEKMDATLSTLKACKHLALSTNNIEKIS-SLSGMENLRILSLGRNLIKKIENLDAVADTL 100 Query: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFST 793 L + N + SL S + +L NL + + N++ GE K + L EDL Sbjct: 101 EELWISYNQIASL-SGIEKLVNLRVLYMSNNKIT----NWGEID--KLAALDKLEDLLLA 153 Query: 794 LPPEVKE 800 P + Sbjct: 154 GNPLYND 160 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 34/153 (22%), Positives = 58/153 (37%), Gaps = 20/153 (13%) Query: 457 PDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLK 516 P + +++ L K L L + + ENLR L + IK+I Sbjct: 41 PIEKMDATLSTLKACKHLALSTNNIEKISSLSGM--ENLRILSLGRNLIKKIENLDAVAD 98 Query: 517 TLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV----------- 565 TLEEL ++ N A + G+ +L L+VL + +N + + Sbjct: 99 TLEELWISYNQIAS------LSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLL 152 Query: 566 -GVHLQKLSINNEGTKLIVLNSLKKMVNLTELE 597 G L N T + +K++ NL +L+ Sbjct: 153 AGNPLYNDYKENNATSEYRIEVVKRLPNLKKLD 185 >3TSR-E nrPDB Length = 457 Score = 59.7 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 71/381 (18%), Positives = 143/381 (37%), Gaps = 61/381 (16%) Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR------ 496 +++V L+ L + I ++ L EL L + + + L+ Sbjct: 26 YEVVRLDDCGLTEVRCKDISSAVQANPALTELSLRTNELGD--GGVGLVLQGLQNPTCKI 83 Query: 497 -ALHIKFTDIKE-----IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR----ELKRL 546 L ++ + E +P + SL TL ELHL N + ++ +GL+ L++L Sbjct: 84 QKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKL 143 Query: 547 KVLRLKSNLSKLPQV--VTDVGVHLQKLSINNEGTKLIVLNSL-KKMVN----LTELELI 599 ++ + + V V ++L ++N + L + + + L L+L Sbjct: 144 QLEYCNLTATSCEPLASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLE 203 Query: 600 RCDLE-----RIPHSIFSLHNLQEIDLKDNNL--KTIEEIISFQHLH--RLTCLKLWYNH 650 C + + + S +LQE+DL N L I + L +L L LW Sbjct: 204 NCGITAANCKDLCDVVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECD 263 Query: 651 I-----AYIPIQIGNLTNLERLYLNRNKIEKIPTQLF------YCRKLRYLDLSHNNLT- 698 I + + +L+ L L N+++ +L +L L + +LT Sbjct: 264 ITAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTA 323 Query: 699 -FLPADIGLL---QNLQNLAVTANRIE-----------ALPPELFQCRKLRALHLGNNVL 743 P +L ++L L +++N + + P + + L + N+ Sbjct: 324 ASCPYFCSVLTKSRSLLELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNSGC 383 Query: 744 QSLPSRVGELTNLTQIELRGN 764 SL + + +L +++L N Sbjct: 384 SSLANVLLANRSLRELDLSNN 404 Score = 49.3 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 78/208 (37%), Gaps = 36/208 (17%) Query: 595 ELELIRCDLER-----IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC----LK 645 + L C L I ++ + L E+ L+ N L + Q L TC L Sbjct: 28 VVRLDDCGLTEVRCKDISSAVQANPALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLS 87 Query: 646 LWYNHIAY-----IPIQIGNLTNLERLYLNRN-----KIEKIPTQLFYCR-KLRYLDLSH 694 L + +P + +L+ L L+LN N ++ + L + +L L L + Sbjct: 88 LQNCGLTEAGCGILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEY 147 Query: 695 NNLTF-----LPADIGLLQNLQNLAVTANRI---------EALPPELFQCRKLRALH--L 738 NLT L + + + + + L ++ N + + L Q L+ + + Sbjct: 148 CNLTATSCEPLASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGI 207 Query: 739 GNNVLQSLPSRVGELTNLTQIELRGNRL 766 + L V +L +++L N+L Sbjct: 208 TAANCKDLCDVVASKASLQELDLSSNKL 235 Score = 38.9 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 85/239 (35%), Gaps = 30/239 (12%) Query: 434 MLSGIPDTVFDL--VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491 + G+ D+ L ++LE + + +A L+EL L A A Sbjct: 186 LCQGLKDSACQLESLKLENCGITAANCKDLCDVVASKASLQELDLSSNKLG-NAGIAALC 244 Query: 492 RENLR-----------ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540 L I K++ + + ++L+EL L N + ++ + L Sbjct: 245 PGLLLPSCKLRTLWLWECDITAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESL 304 Query: 541 RE----LKRLKVLRLKSNLSKLPQ--VVTDVGVHLQKLSINNEGTKLIVLNSLKKM---- 590 E L+ L + + P V L +L +++ + L K Sbjct: 305 LEPGCQLESLWIKTCSLTAASCPYFCSVLTKSRSLLELQMSSNPLGDEGVQELCKALSQP 364 Query: 591 -VNLTELELIRCDL-----ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTC 643 L EL L CD+ + + + + +L+E+DL +N + + + L + +C Sbjct: 365 DTVLRELWLGDCDVTNSGCSSLANVLLANRSLRELDLSNNCMGGPGVLQLLESLKQPSC 423 >2BNH-A nrPDB Length = 457 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 65/362 (17%), Positives = 117/362 (32%), Gaps = 62/362 (17%) Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA----LAFLREN 494 P + L+ L +P ++ L L+EL L +A L Sbjct: 79 PTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLG-DAGLRLLCEGLLDPQ 137 Query: 495 --LRALHIKFTDIKEIP-LWIYSL----KTLEELHLTGNLSAENNRYIVIDGL-RELKRL 546 L L +++ + + S+ + L+EL ++ N E ++ GL +L Sbjct: 138 CHLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQL 197 Query: 547 KVLRLKSNLSKLPQ-----VVTDVGVHLQKLSINNEG-----TKLIVLNSLKKMVNLTEL 596 + LRL++ + L++L + + G + L L L Sbjct: 198 ETLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTL 257 Query: 597 ELIRCDL-----ERIPHSIFSLHNLQEIDLKDNNL----KTIEEIISFQHLHRLTCLKLW 647 L CD+ + + + L+E+ L N L + Q +L L + Sbjct: 258 WLWECDITASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVK 317 Query: 648 YNHI-----AYIPIQIGNLTNLERLYLNRNKI------EKIPTQLFYCRKLRYLDLSHNN 696 + ++ + + +L L L+ NK+ E LR L Sbjct: 318 SCSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDSGIQELCQALSQPGTTLRVL-----C 372 Query: 697 LTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756 L +L +L + R LR L L NN + P + L +L Sbjct: 373 LGDCEVTNSGCSSLASLLLAN-------------RSLRELDLSNNCVGD-PGVLQLLGSL 418 Query: 757 TQ 758 Q Sbjct: 419 EQ 420 Score = 57.0 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 77/380 (20%), Positives = 142/380 (37%), Gaps = 59/380 (15%) Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA------PALAFLRENLR 496 +++V L+ L I ++ L EL L + + ++ Sbjct: 26 YEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCK-IQ 84 Query: 497 ALHIKFTDIKE-----IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR----ELKRLK 547 L ++ + E +P + SL TL ELHL+ N + ++ +GL L++L+ Sbjct: 85 KLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQ 144 Query: 548 VLRLKSNLSKLPQV--VTDVGVHLQKLSINNE-----GTKLIVLNSLKKMVNLTELELIR 600 + + + + V L++L+++N G +++ L L L Sbjct: 145 LEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLETLRLEN 204 Query: 601 CDLE-----RIPHSIFSLHNLQEIDLKDNNL--KTIEEIIS--FQHLHRLTCLKLWY--- 648 C L + + S +L+E+DL N L I E+ RL L LW Sbjct: 205 CGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLWLWECDI 264 Query: 649 --NHIAYIPIQIGNLTNLERLYLNRNKIEK------IPTQLFYCRKLRYLDLSHNNLT-- 698 + + + L+ L L NK+ + L +L L + +LT Sbjct: 265 TASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKSCSLTAA 324 Query: 699 ---FLPADIGLLQNLQNLAVTANR-----IEALPPELFQ-CRKLRALHLG-----NNVLQ 744 + + ++L L +++N+ I+ L L Q LR L LG N+ Sbjct: 325 CCQHVSLMLTQNKHLLELQLSSNKLGDSGIQELCQALSQPGTTLRVLCLGDCEVTNSGCS 384 Query: 745 SLPSRVGELTNLTQIELRGN 764 SL S + +L +++L N Sbjct: 385 SLASLLLANRSLRELDLSNN 404 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 40/200 (20%), Positives = 72/200 (36%), Gaps = 31/200 (15%) Query: 598 LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH----RLTCLKLWYNHIAY 653 L + I ++ + +L E+ L+ N L + Q L ++ L L + Sbjct: 36 LTEEHCKDIGSALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTE 95 Query: 654 -----IPIQIGNLTNLERLYLNRN-----KIEKIPTQLFYCR-KLRYLDLSHNNLTF--- 699 +P + +L L L+L+ N + + L + L L L + LT Sbjct: 96 AGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASC 155 Query: 700 --LPADIGLLQNLQNLAVTANRI---------EALPPELFQCRKLRALH--LGNNVLQSL 746 L + + + L+ L V+ N I + L Q LR + L + L Sbjct: 156 EPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLETLRLENCGLTPANCKDL 215 Query: 747 PSRVGELTNLTQIELRGNRL 766 V +L +++L N L Sbjct: 216 CGIVASQASLRELDLGSNGL 235 Score = 37.0 bits (84), Expect = 0.037, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 58/169 (34%), Gaps = 22/169 (13%) Query: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI--EKI 677 L D + ++ + RL L H I + +L L L N++ + Sbjct: 10 QLSDARWTELLPLLQQYEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRTNELGDAGV 69 Query: 678 PTQLFYCR----KLRYLDLSHNNLTF-----LPADIGLLQNLQNLAVTANRIEAL----- 723 L + K++ L L + +LT LP+ + L L+ L ++ N + Sbjct: 70 HLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLL 129 Query: 724 ------PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766 P + +L L + L S + L ++ + N + Sbjct: 130 CEGLLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDI 178 >3G04-C nrPDB Length = 239 Score = 55.5 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 42/201 (20%), Positives = 85/201 (42%), Gaps = 15/201 (7%) Query: 587 LKKMVNL----TELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRL 641 ++++ +L L+LI L IP FS L N+ I + + E SF +L ++ Sbjct: 23 IQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKV 82 Query: 642 TCLKLWYNH-IAYI-PIQIGNLTNLERLYLNRNKIEKIP--TQLFYCRKLRYLDLSHNN- 696 T +++ + YI P + L L+ L + ++ P T+++ L+++ N Sbjct: 83 THIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPY 142 Query: 697 LTFLPADI--GLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNV-LQSLPSRVGE- 752 +T +P + GL L + N ++ F KL A++L N L + Sbjct: 143 MTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGG 202 Query: 753 -LTNLTQIELRGNRLECLPVE 772 + + +++ + LP + Sbjct: 203 VYSGPSLLDVSQTSVTALPSK 223 >1DCE-A nrPDB Length = 567 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 43/105 (40%), Gaps = 8/105 (7%) Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP 678 + L +L + + L +T L L +N + +P + L LE L + N +E + Sbjct: 446 LHLAHKDLTVLCHLE---QLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENV- 501 Query: 679 TQLFYCRKLRYLDLSHNNL---TFLPADIGLLQNLQNLAVTANRI 720 + +L+ L L +N L + + + L L + N + Sbjct: 502 DGVANLPRLQELLLCNNRLQQSAAIQPLVSCPR-LVLLNLQGNSL 545 Score = 49.0 bits (115), Expect = 9e-06, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 61/143 (42%), Gaps = 7/143 (4%) Query: 534 YIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNL 593 + + + ++ + L+S V+ ++ L + ++ L VL L++++ + Sbjct: 408 FSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHK--DLTVLCHLEQLLLV 465 Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653 T L+L L +P ++ +L L+ + DN L+ ++ +L RL L L N + Sbjct: 466 THLDLSHNRLRALPPALAALRCLEVLQASDNALENVD---GVANLPRLQELLLCNNRLQQ 522 Query: 654 IP--IQIGNLTNLERLYLNRNKI 674 + + L L L N + Sbjct: 523 SAAIQPLVSCPRLVLLNLQGNSL 545 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 7/138 (5%) Query: 655 PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714 P++ L +L +L N + K+ +R L L+H +LT L LL + +L Sbjct: 416 PMRAAYLDDLRSKFLLENSVLKM-----EYADVRVLHLAHKDLTVLCHLEQLLL-VTHLD 469 Query: 715 VTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELG 774 ++ NR+ ALPP L R L L +N L+++ V L L ++ L NRL+ Sbjct: 470 LSHNRLRALPPALAALRCLEVLQASDNALENV-DGVANLPRLQELLLCNNRLQQSAAIQP 528 Query: 775 ECPLLKRSGLVVEEDLFS 792 + L ++ + Sbjct: 529 LVSCPRLVLLNLQGNSLC 546 Score = 37.8 bits (86), Expect = 0.020, Method: Composition-based stats. Identities = 36/152 (23%), Positives = 61/152 (40%), Gaps = 12/152 (7%) Query: 413 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLK 472 +D +R + + K L +L + ++ VL L D+T+ + QL + Sbjct: 414 VDPMRAAYLDDLRSKFLLENSVLK------MEYADVRVLHLAH-KDLTVLCHLEQLLLVT 466 Query: 473 ELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENN 532 L L H + PALA LR L L ++ + + +L L+EL L N Sbjct: 467 HLDLSHNRLRALPPALAALR-CLEVLQASDNALENVD-GVANLPRLQELLLCNNRL---Q 521 Query: 533 RYIVIDGLRELKRLKVLRLKSNLSKLPQVVTD 564 + I L RL +L L+ N + + + Sbjct: 522 QSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQE 553 >4PEQ-B nrPDB Length = 456 Score = 52.4 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 103/336 (30%), Gaps = 49/336 (14%) Query: 470 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKE-----IPLWIYSLKTLEELHLT 524 L+ L + L L LR LH+ + + + + + E Sbjct: 86 SLQNCCLTEAGCGVLPGVLRSL-PTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQL 144 Query: 525 GNLSAENNRYIVIDG-LRELKRLKVLRLKSN------LSKLPQVVTDVGVHLQKLSINNE 577 S + LR + LK L + +N + L + + + L+ L + N Sbjct: 145 EYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENC 204 Query: 578 GTKLIVLNSLKKMV----NLTELELIRCDLERI------PHSIFSLHNLQEIDLKDNNLK 627 G L +V +L +L+L L P + L+ + L + +L Sbjct: 205 GLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLT 264 Query: 628 TIEEIISFQHLHR---LTCLKLWYNHIAYIPIQI------GNLTNLERLYLNRNKIEK-- 676 + L L L L N + Q+ LE L++ Sbjct: 265 VSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAAC 324 Query: 677 ---IPTQLFYCRKLRYLDLSHNNLTFLPADIGLL------QNLQNLA-----VTANRIEA 722 + L + L L LS N L + L+ L +T + Sbjct: 325 CQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGG 384 Query: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758 L L LR L L NN L P + L +L Q Sbjct: 385 LASLLLASPSLRELDLSNNGLGD-PGVLQLLGSLEQ 419 Score = 51.3 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 125/366 (34%), Gaps = 106/366 (28%) Query: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELK-RLKVLRLKSNL------SKL 558 K+I + + +L EL L N + +V+ GL+ +++ L L++ L Sbjct: 41 KDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVL 100 Query: 559 PQVVTDVGVHLQKLSINNE-----GTKLIVLNSLKKMVNLTELELIRCDL-----ERIPH 608 P V+ + L++L +++ G +L+ L L +L+L C L E + Sbjct: 101 PGVLRSLPT-LRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAA 159 Query: 609 SIFSLHNLQEIDLKDNNLKTIEEIISFQHLH----RLTCLKLWYNHI-----AYIPIQIG 659 + + +L+E+ + +N++ + L +L LKL + + + Sbjct: 160 VLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVA 219 Query: 660 NLTNLERLYLNRNKI-----EKIPTQLFYCRK---------------------------- 686 + +L+ L L N++ ++ L Sbjct: 220 SQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKE 279 Query: 687 -LRYLDLSHNNLTFLPADIGLLQ------NLQNLAVTANRI-----EALPPELFQCRKLR 734 L+ L L+ N+L A + L++L V + + L Q + L Sbjct: 280 ALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLL 339 Query: 735 ALHLGNN-------------------VLQSLPSRVGELTN---------------LTQIE 760 L L +N VL+ L ELTN L +++ Sbjct: 340 ELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELD 399 Query: 761 LRGNRL 766 L N L Sbjct: 400 LSNNGL 405 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 47/208 (22%), Positives = 81/208 (38%), Gaps = 36/208 (17%) Query: 595 ELELIRCDLER-----IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH----RLTCLK 645 + L C L I ++ + +L E+ L+ N L ++ Q L ++ L Sbjct: 27 VVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLS 86 Query: 646 LWYNHIAY-----IPIQIGNLTNLERLYLNRN-----KIEKIPTQLFYCR-KLRYLDLSH 694 L + +P + +L L L+L+ N + + L R +L L L + Sbjct: 87 LQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEY 146 Query: 695 NNLTF-----LPADIGLLQNLQNLAVTANRI-----EALPPELFQCR-KLRALHLGN--- 740 +LT L A + ++L+ L V+ N I +AL L + +L L L N Sbjct: 147 CSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGL 206 Query: 741 --NVLQSLPSRVGELTNLTQIELRGNRL 766 + L V +L ++L NRL Sbjct: 207 TAANCKDLCGIVASQASLKDLDLGSNRL 234 >2IFG-A nrPDB Length = 347 Score = 49.3 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 47/130 (36%), Gaps = 2/130 (1%) Query: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI- 654 L R H + NL E+ +++ E+ + L L L + + + ++ Sbjct: 13 LRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVA 72 Query: 655 PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714 P L RL L+ N +E + + L+ L LS N L + LQ + Sbjct: 73 PDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLH-CSCALRWLQRWEEEG 131 Query: 715 VTANRIEALP 724 + + L Sbjct: 132 LGGVPEQKLQ 141 Score = 42.8 bits (99), Expect = 6e-04, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 41/109 (37%), Gaps = 5/109 (4%) Query: 524 TGNLSAENNRYIVIDGLREL---KRLKVLRLKS--NLSKLPQVVTDVGVHLQKLSINNEG 578 G+ R +D L L + L L +++ +L L L+ L+I G Sbjct: 8 HGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSG 67 Query: 579 TKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627 + + ++ L+ L L LE + +LQE+ L N L Sbjct: 68 LRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLH 116 Score = 41.2 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 3/91 (3%) Query: 681 LFYCRKLRYLDLSHNN--LTFLPADIGLLQNLQNLAVTANRIEALPPELFQ-CRKLRALH 737 L L L + + D+ L L+NL + + + + P+ F +L L+ Sbjct: 27 LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLN 86 Query: 738 LGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 L N L+SL + + +L ++ L GN L C Sbjct: 87 LSFNALESLSWKTVQGLSLQELVLSGNPLHC 117 Score = 37.0 bits (84), Expect = 0.033, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 27/63 (42%) Query: 464 SIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHL 523 + L L+ L + + + AP L L++ F ++ + +L+EL L Sbjct: 51 DLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVL 110 Query: 524 TGN 526 +GN Sbjct: 111 SGN 113 >4PBW-B nrPDB Length = 283 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 47/108 (43%), Gaps = 13/108 (12%) Query: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIE 721 T+++ ++RN I I + + L+ L N + D+ L LQ L + + + Sbjct: 41 TSIQITDISRN-ITSIH--IENWKNLQTL----NAV-----DMELYTGLQRLTIRNSGLR 88 Query: 722 ALPPELF-QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 + P F + LR + L N L +L ++ + L + L N +C Sbjct: 89 NIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERNPFQC 136 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 41/106 (38%), Gaps = 15/106 (14%) Query: 591 VNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH 650 ++ ++ R + I I + NLQ ++ D L T L L + + Sbjct: 41 TSIQITDISRN-ITSIH--IENWKNLQTLNAVDMELYT-----------GLQRLTIRNSG 86 Query: 651 IAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN 695 + I P +L + L+ N++ + QLF +L L L N Sbjct: 87 LRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERN 132 >6ICZ-o nrPDB Length = 255 Score = 47.0 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 30/106 (28%), Positives = 41/106 (38%), Gaps = 4/106 (3%) Query: 665 ERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALP 724 L L KI I + +D S N + L LL+ L+ L V NRI + Sbjct: 22 RELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKL-DGFPLLRRLKTLLVNNNRICRIG 80 Query: 725 PELFQC-RKLRALHLGNNVLQSLP--SRVGELTNLTQIELRGNRLE 767 L Q L L L NN L L + L +LT + + N + Sbjct: 81 EGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVT 126 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 6/107 (5%) Query: 595 ELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI 654 EL+L + I + +L ID DN ++ ++ F L RL L + N I I Sbjct: 23 ELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLD---GFPLLRRLKTLLVNNNRICRI 79 Query: 655 PIQI-GNLTNLERLYLNRNKIEKIP--TQLFYCRKLRYLDLSHNNLT 698 + L L L L N + ++ L + L YL + N +T Sbjct: 80 GEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVT 126 Score = 38.6 bits (88), Expect = 0.012, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 44/131 (33%), Gaps = 27/131 (20%) Query: 527 LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNS 586 + +N +DG L+RLK L + +N + +G L Sbjct: 47 IDFSDNEIRKLDGFPLLRRLKTLLVNNN------RICRIGEGLD---------------- 84 Query: 587 LKKMVNLTELELIRCDLERIP--HSIFSLHNLQEIDLKDNNLKTIEEIISFQ--HLHRLT 642 + + LTEL L L + + SL +L + + N + + + + ++ Sbjct: 85 -QALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVR 143 Query: 643 CLKLWYNHIAY 653 L + Sbjct: 144 VLDFQKVKLKE 154 >5LJ5-W nrPDB Length = 238 Score = 45.5 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 33/208 (15%), Positives = 72/208 (34%), Gaps = 14/208 (6%) Query: 563 TDVGVHLQKLSINNEGTKLIVLNSLKKMVN-LTELELIRCDLERIPHSIFSLHNLQEIDL 621 D V L+ L + + + +SLK + L+L DL IP + ++ + L Sbjct: 25 VDKCVILRDLQLETDSES--MPSSLKHLTKPTHILDLTNNDLIMIP-DLSRRDDIHTLLL 81 Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPT-- 679 NN+ ++ + ++ LT + L+ L L N++ + Sbjct: 82 GRNNIVEVDGRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYR 141 Query: 680 --QLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALH 737 L L LD + + + + + A+ + + + ++ Sbjct: 142 EHVLRLVPHLETLDFQNVTAEERKSAMSFPRQADGDTLGPVN-TAIRDNGSRDKTMEIMN 200 Query: 738 LGNNVLQ-----SLPSRVGELTNLTQIE 760 L + + L ++ E T+L +I Sbjct: 201 LVVSKMTVERRNELKKQLAEATSLEEIA 228 >4PBV-A nrPDB Length = 268 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 28/114 (24%), Positives = 46/114 (40%), Gaps = 13/114 (11%) Query: 656 IQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAV 715 GNL L +RN I I + + L+ L N + D+ L LQ L + Sbjct: 20 PDDGNLFPLLEGQDSRN-ITSIH--IENWKNLQTL----NAV-----DMELYTGLQRLTI 67 Query: 716 TANRIEALPPELF-QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 + + + P F + LR + L N L +L ++ + L + L N +C Sbjct: 68 RNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERNPFQC 121 Score = 38.6 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 37/95 (38%), Gaps = 14/95 (14%) Query: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI-PIQIGN 660 ++ I I + NLQ ++ D L T L L + + + I P Sbjct: 36 NITSIH--IENWKNLQTLNAVDMELYT-----------GLQRLTIRNSGLRNIQPRAFAK 82 Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN 695 +L + L+ N++ + QLF +L L L N Sbjct: 83 NPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERN 117 >2Q4G-W nrPDB Length = 461 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 83/235 (35%), Gaps = 37/235 (15%) Query: 590 MVNLTELELIRCDLER-----IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH----R 640 + + L C L I ++ L E++L+ N L + Q L + Sbjct: 27 LQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86 Query: 641 LTCLKLWYNHI-----AYIPIQIGNLTNLERLYLNRN-----KIEKIPTQLFYCR-KLRY 689 + L L + + + L L+ L+L+ N ++ + L + +L Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146 Query: 690 LDLSHNNLTF-----LPADIGLLQNLQNLAVTANRI---------EALPPE--LFQCRKL 733 L L + +L+ L + + + + L V+ N I + L + KL Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206 Query: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEE 788 + + ++ + L V +L ++ L N+L + + CP L + Sbjct: 207 ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMA-ELCPGLLHPSSRLRT 260 Score = 39.3 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 113/366 (30%), Gaps = 83/366 (22%) Query: 483 IEAPALAFLRENLRALHIKFTDIKEIP-------LWIYSLKTLEELHLTGNLSAENNRYI 535 + + + L L+++ ++ ++ L S K +++L L + Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK-IQKLSLQNCCLTGAGCGV 104 Query: 536 VIDGLRELKRLKVLRLKSNL------SKLPQVVTDVGVHLQKLSINNEGTKL----IVLN 585 + LR L L+ L L NL L + + D L+KL + + + Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164 Query: 586 SLKKMVNLTELELIRCDLERIPHSI------FSLHNLQEIDLKDNNLKT--IEEIISFQH 637 L+ + EL + D+ + S L+ + L+ + + ++ Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224 Query: 638 LHR-LTCLKLWYNHIAYI------PIQIGNLTNLERLYLNRNKIE-----KIPTQLFYCR 685 L L L N + + P + + L L++ I + L Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284 Query: 686 KLRYLDLSHNNLTFLPADIGLLQ------NLQNLAVTANRI-----EALPPELFQCRKLR 734 L+ L L+ N L A + L++L V + L Q R L Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344 Query: 735 ALHLGNNVLQSL-----------PSRVGEL-----------------------TNLTQIE 760 L + NN L+ P V + +L +++ Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404 Query: 761 LRGNRL 766 L N L Sbjct: 405 LSNNCL 410 Score = 30.5 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 57/170 (33%), Gaps = 22/170 (12%) Query: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI--EKI 677 +L D + ++ + RL L I + L L L N++ + Sbjct: 14 ELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGV 73 Query: 678 PTQLFYCR----KLRYLDLSHNNLT-----FLPADIGLLQNLQNLAVTAN-----RIEAL 723 L + K++ L L + LT L + + L LQ L ++ N ++ L Sbjct: 74 HCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLL 133 Query: 724 PPELFQCR------KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767 L + +L L + L S + + ++ + N + Sbjct: 134 CEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183 >3JB9-j nrPDB Length = 239 Score = 43.9 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 41/198 (20%), Positives = 69/198 (34%), Gaps = 29/198 (14%) Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN-LTNLERLYLNRNKIEKI 677 ID DN++ + +F + RL L N I I IG L NL+ L L +N +++I Sbjct: 46 IDFTDNDI---RYLGNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEI 102 Query: 678 P--TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRA 735 L C +L L N + + L + +++ L Sbjct: 103 ADLDPLASCPQLTNLSCIDNPVA--------QKQYYRLYL-----------IWRIPSLHI 143 Query: 736 LHLG---NNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFS 792 L N G++ N T+I ++ +L + Sbjct: 144 LDFERVRRNERLRAEEVFGQIQNPTEIASSIMGVKSRVFDLAAL-VQSHPEANSPITTGY 202 Query: 793 TLPPEVKERLWRADKEQA 810 TL PE +E++ A K + Sbjct: 203 TLTPEEREKIKEAIKNAS 220 Score = 42.8 bits (99), Expect = 6e-04, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 49/138 (35%), Gaps = 11/138 (7%) Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLK-VLRLKSNLS 556 + + + ++P +I LK EL L + +I+ L L+ + + N Sbjct: 1 MRLNAEFLSQVPSFISPLKE-TELDLRWY------QIPIIENLGVLRDVHDAIDFTDNDI 53 Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIP--HSIFSLH 614 + + LQ L N I + K + NL L L + L+ I + S Sbjct: 54 RYLGNFPRMKR-LQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCP 112 Query: 615 NLQEIDLKDNNLKTIEEI 632 L + DN + + Sbjct: 113 QLTNLSCIDNPVAQKQYY 130 Score = 42.0 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 29/71 (40%), Gaps = 1/71 (1%) Query: 584 LNSLKKMVNLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLT 642 L + +M L L + I I L NL+ + L N+L+ I ++ +LT Sbjct: 56 LGNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLT 115 Query: 643 CLKLWYNHIAY 653 L N +A Sbjct: 116 NLSCIDNPVAQ 126 >6J5T-G nrPDB Length = 852 Score = 43.6 bits (101), Expect = 4e-04, Method: Composition-based stats. Identities = 51/273 (18%), Positives = 104/273 (38%), Gaps = 19/273 (6%) Query: 528 SAENNRYIVIDGLRELKRLKVLRLKSNLSKLP--QVVTDVGV--HLQKLSINNEGTKLIV 583 + + K L+VL + ++ P +++ ++ HL LS++N + Sbjct: 543 EVNKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQF 602 Query: 584 LNSLKKMVNLTELELIRCD-LERIPHSIFSLHNLQEIDLKDNNLK--TIEEIISFQHLHR 640 S++ + NL L+ C L+++ I L +D+ + + I S L Sbjct: 603 PRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEV 662 Query: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKI-PTQLFYCRKL-RYLDLSHNNLT 698 L K ++ ++ NLTNL +L L+ + ++I +L L + + +S N Sbjct: 663 LLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYD 722 Query: 699 FLPADIGL-------LQNLQNLAVTANRIEALPPELF--QCRKLRALHLGNNVLQSLPSR 749 D+ L L++ ++ P L + LR + + + L + Sbjct: 723 SYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQEP 782 Query: 750 VGELTNLTQIELRGNRLECLPVELGECPLLKRS 782 N T + G L L + +L++S Sbjct: 783 FWGNEN-THWRIEGLMLSSLSDLDMDWEVLQQS 814 >4WYK-A nrPDB Length = 461 Score = 38.9 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 28/67 (41%), Gaps = 4/67 (5%) Query: 588 KKMVNLTELELIRCDLERI---PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644 + + L L L L R+ + NL+ ++L N LK+ E+ + L L L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 226 Query: 645 KLWYNHI 651 L N + Sbjct: 227 WLDGNSL 233 Score = 37.0 bits (84), Expect = 0.032, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 30/67 (44%), Gaps = 6/67 (8%) Query: 659 GNLTNLERLYLNRNKIEK---IPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNL 713 N+ L L L+ N++ + + + + L+ L+LS N L I L+ L+ L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 226 Query: 714 AVTANRI 720 + N + Sbjct: 227 WLDGNSL 233 Score = 35.1 bits (79), Expect = 0.12, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 50/130 (38%), Gaps = 12/130 (9%) Query: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL--QNLAVTANRIEALPPEL-- 727 N+++ P Q+ + + + + +L QN+ V NR + L Sbjct: 108 NELK--PEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRI 165 Query: 728 --FQCRKLRALHLGNNVLQSLPSR---VGELTNLTQIELRGNRLECLPVELGECPLLKRS 782 +L +L+L NN L L V + NL + L GN L+ EL + LK Sbjct: 166 IEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKGLKLE 224 Query: 783 GLVVEEDLFS 792 L ++ + Sbjct: 225 ELWLDGNSLC 234 Score = 33.9 bits (76), Expect = 0.31, Method: Composition-based stats. Identities = 25/118 (21%), Positives = 50/118 (42%), Gaps = 16/118 (13%) Query: 685 RKLRYLDLSHNNLTFL---PADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHL--- 738 +L L+LS+N L L + + NL+ L ++ N +++ EL + + L+ L Sbjct: 171 PELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKGLKLEELWLD 229 Query: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPP 796 GN++ + + ++ + + R +L L P+ +TLPP Sbjct: 230 GNSLCDTFRDQSTYISAIRE---RFPKLLRLDGHELPPPIAFDVEA------PTTLPP 278 Score = 32.8 bits (73), Expect = 0.55, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 26/65 (40%), Gaps = 4/65 (6%) Query: 637 HLHRLTCLKLWYNHIAYIPIQ---IGNLTNLERLYLNRNKIEKIPTQL-FYCRKLRYLDL 692 ++ L L L N + + + NL+ L L+ N+++ KL L L Sbjct: 169 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWL 228 Query: 693 SHNNL 697 N+L Sbjct: 229 DGNSL 233 >1KOH-A nrPDB Length = 277 Score = 38.6 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 29/68 (42%), Gaps = 4/68 (5%) Query: 588 KKMVNLTELELIRCDLERI---PHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644 + + L L L L R+ + NL+ ++L N LK+ E+ + L L L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 225 Query: 645 KLWYNHIA 652 L N ++ Sbjct: 226 WLDGNSLS 233 Score = 36.6 bits (83), Expect = 0.038, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 6/103 (5%) Query: 625 NLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK---IPTQL 681 +LK + + L + A + I N+ L L L+ N++ + + + + Sbjct: 133 DLKGLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIV 192 Query: 682 FYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNLAVTANRIEA 722 L+ L+LS N L I L+ L+ L + N + Sbjct: 193 QKAPNLKILNLSGNELKSERELDKIKGLK-LEELWLDGNSLSD 234 Score = 33.9 bits (76), Expect = 0.28, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 54/150 (36%), Gaps = 15/150 (10%) Query: 571 KLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQE--------IDLK 622 + IN+ +LN LK + +L+LI L L+ ID+ Sbjct: 93 SIIINSSAPPHTILNELKP-EQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVV 151 Query: 623 DNNLKTIEEIIS--FQHLHRLTCLKLWYNHIAYIPIQ---IGNLTNLERLYLNRNKIEKI 677 N ++ + +++ L L L N + + + NL+ L L+ N+++ Sbjct: 152 LNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSE 211 Query: 678 PTQL-FYCRKLRYLDLSHNNLTFLPADIGL 706 KL L L N+L+ D Sbjct: 212 RELDKIKGLKLEELWLDGNSLSDTFRDQST 241 Score = 33.2 bits (74), Expect = 0.42, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 52/130 (40%), Gaps = 12/130 (9%) Query: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL--QNLAVTANRIEALPPEL-- 727 N+++ P Q+ + + + + +L QN+ V NR ++ L Sbjct: 107 NELK--PEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSSMAATLRI 164 Query: 728 --FQCRKLRALHLGNNVLQSLPSR---VGELTNLTQIELRGNRLECLPVELGECPLLKRS 782 +L +L+L NN L L V + NL + L GN L+ EL + LK Sbjct: 165 IEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKGLKLE 223 Query: 783 GLVVEEDLFS 792 L ++ + S Sbjct: 224 ELWLDGNSLS 233 Score = 32.0 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 54/135 (40%), Gaps = 20/135 (14%) Query: 672 NKIEKIPTQLF----YCRKLRYLDLSHNNLTFL---PADIGLLQNLQNLAVTANRIEALP 724 N+ + L +L L+LS+N L L + + NL+ L ++ N +++ Sbjct: 153 NRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKS-E 211 Query: 725 PELFQCRKLRALHL---GNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKR 781 EL + + L+ L GN++ + + ++ + + R +L L P+ Sbjct: 212 RELDKIKGLKLEELWLDGNSLSDTFRDQSTYISAIRE---RFPKLLRLDGHELPPPIAFD 268 Query: 782 SGLVVEEDLFSTLPP 796 +TLPP Sbjct: 269 VEA------PTTLPP 277 >4K17-A nrPDB Length = 669 Score = 38.2 bits (87), Expect = 0.014, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 78/238 (32%), Gaps = 46/238 (19%) Query: 568 HLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDL---------ERIPHSIFSLHNLQE 618 +L S+ + G + + K L L L + L + + + + L Sbjct: 283 NLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTH 342 Query: 619 IDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT---------------- 662 +DL N L+ L + N I ++ + + Sbjct: 343 LDLSGNALRG-------DDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCL 395 Query: 663 ---NLERLYLNRNKIEKIPTQLFYCRK----LRYLDLSHNNLTFLPADIGLLQNLQNLAV 715 NL R + K +++P L ++LS L+ P + L L LA Sbjct: 396 AVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLS--PEPLKAL--LLGLAC 451 Query: 716 TANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773 ++ + +L C L G + L + E+ N+T +++ N LE L Sbjct: 452 NH-SLKGVSLDLSNCELGHCLRSGGAQV--LEGCIAEIHNITSLDISDNGLESDLSTL 506 Score = 35.9 bits (81), Expect = 0.076, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 61/163 (37%), Gaps = 27/163 (16%) Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLLQN 709 +A+ P + NL L + + Q K L++L+LS +L+ P + L Sbjct: 271 LAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLS--PKGVNSLCQ 328 Query: 710 LQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQ-----SLPSRVGELTNLTQIELRGN 764 +++AN + L L L N L+ + + + + + ++L Sbjct: 329 ----SLSANPLT--------ASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNT 376 Query: 765 --RLECLPVELGECPLLKRSGLVVEEDLFS-----TLPPEVKE 800 LE + L L + L + +FS +PP K+ Sbjct: 377 ECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQ 419 Score = 33.5 bits (75), Expect = 0.34, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 57/146 (39%), Gaps = 28/146 (19%) Query: 494 NLRALHIKFT----DIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVL 549 N+ +L I D+ + +W+ ++++ L L N +K Sbjct: 488 NITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN----------------FNNMKSK 531 Query: 550 RLKSNLSKLPQVVTDVGVHLQKLSINNEGTK---LIVLNSLKKMVNLTELELIRCDLERI 606 L L L Q++ D LQ LS+ + K I++N+L +LT++++ + + Sbjct: 532 NLTPVLDNLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMGDM 591 Query: 607 PHSIFSL-----HNLQEIDLKDNNLK 627 + + L+ + NN+ Sbjct: 592 GAKMLAKALQINTKLRTVIWDKNNIT 617 Score = 31.6 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 32/157 (20%), Positives = 57/157 (36%), Gaps = 34/157 (21%) Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI-----EKIPTQ 680 + +E F L LKL + I + LE L L + +K+ Sbjct: 212 IAALEYNQWFTKLSS-KDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGA 270 Query: 681 LFYCRK--LRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHL 738 L + L ++L+ N+L + ++ + + LP L+ L+L Sbjct: 271 LAHNPNSGLHTINLAGNSLED-----------RGVSSLSIQFAKLPKG------LKHLNL 313 Query: 739 G---------NNVLQSLPSRVGELTNLTQIELRGNRL 766 N++ QSL + + LT ++L GN L Sbjct: 314 SKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNAL 350 Score = 31.2 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 41/263 (15%), Positives = 89/263 (33%), Gaps = 41/263 (15%) Query: 431 HLFMLSGIPDTVFDLVELEV----LKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAP 486 H++ P+T+ L +L L++ + + L H K P Sbjct: 357 HMYNFLAQPNTIVHL-DLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPP 415 Query: 487 AL--------AFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHL------TGNLSAENN 532 + A ++ NL + +K + L + +L+ + L G+ Sbjct: 416 SFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGG 475 Query: 533 RYIVIDGLRELKRLKVLRLKSN--LSKLPQVVTDVGV--HLQKLSINNEGTKLIVLNSLK 588 ++ + E+ + L + N S L ++ + +Q L++ + N Sbjct: 476 AQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTP 535 Query: 589 KMVNL-----------TELELIRCDLER----IPHSIFSLHNLQEIDLKDNNLKTIEEII 633 + NL L L L+ I +++ S +L ++D+ N + + + Sbjct: 536 VLDNLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMGDMGAKM 595 Query: 634 SFQHLHRLTCLKL---WYNHIAY 653 + L T L+ N+I Sbjct: 596 LAKALQINTKLRTVIWDKNNITA 618 >2P1O-B nrPDB Length = 594 Score = 37.4 bits (85), Expect = 0.026, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 69/184 (37%), Gaps = 30/184 (16%) Query: 592 NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651 NL EL+L D++ + S L N+ + +SF L RL Sbjct: 157 NLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERL---------- 206 Query: 652 AYIPIQIGNLTNLERLYLNRN-KIEKIPTQLFYCRKLRYL-------DLSHNNLTFLPAD 703 + NL+ L LNR +EK+ T L +L L ++ + + L Sbjct: 207 ------VTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGLSVA 260 Query: 704 IGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLG-----NNVLQSLPSRVGELTNLT 757 + + L+ L+ + + A LP C +L L+L + L L + +L L Sbjct: 261 LSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLW 320 Query: 758 QIEL 761 ++ Sbjct: 321 VLDY 324 >1PU7-A nrPDB Length = 218 Score = 33.9 bits (76), Expect = 0.30, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 38/115 (33%), Gaps = 14/115 (12%) Query: 536 VIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTE 595 V+D LK LK L L N L + VL SL+ + N Sbjct: 1 VLDSFEILKALKSLDLLKNAPAWWWPNALKFEALLGAVLTQNTKFEAVLKSLENLKNAFI 60 Query: 596 LE----LIRCDLERI----------PHSIFSLHNLQEIDLKDNNLKTIEEIISFQ 636 LE + + I P ++ + IDL N LK + +F+ Sbjct: 61 LENDDEINLKKIAYIEFSKLAECVRPSGFYNQKAKRLIDLSGNILKDFQSFENFK 115 >4NUY-A nrPDB Length = 899 Score = 33.5 bits (75), Expect = 0.32, Method: Composition-based stats. Identities = 32/193 (16%), Positives = 63/193 (32%), Gaps = 20/193 (10%) Query: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDL 603 K LK + LK L L++ + GT+ L L L + Sbjct: 341 KALKTVMLKDKSYDLIDEKDFPDKALREAVMAQVGTRKGDLERFNG-----TLRLDNPAI 395 Query: 604 ERIPHSIFSLHNLQEIDLKD-NNLKTIEEIISFQHLHR--------LTCLKLWYNH---- 650 + + + L ++DL + + ++ + ++ L K Sbjct: 396 QSL-EGLNKFKKLAQLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKKDNKEEPAT 454 Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPT-QLFYCRKLRYLDLSHNNLTFLPADIGLLQN 709 I + +++ LT L+ L L+ E + L +D+S N L P Sbjct: 455 IPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTENRQIF 514 Query: 710 LQNLAVTANRIEA 722 L+ +N + + Sbjct: 515 DTMLSTISNHVGS 527 Score = 29.7 bits (65), Expect = 5.6, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 24/63 (38%), Gaps = 3/63 (4%) Query: 450 VLKLELIPDVTIPP---SIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK 506 K TIPP ++ LTGLKEL L + A A +L + I + Sbjct: 444 YKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLD 503 Query: 507 EIP 509 P Sbjct: 504 LAP 506 >3OT5-A nrPDB Length = 403 Score = 32.8 bits (73), Expect = 0.59, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 62/150 (41%), Gaps = 12/150 (8%) Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180 A ++ +L H L N + FP ++ ++ SP T +A + E Sbjct: 132 LATFYQQKMLGHVEAGLRTWNKYSPFPEEMNR--QLTGVMADIHFSP-TKQAKENLLAEG 188 Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRT-KSRIEQGIVDRSETGVLDKKEGEQ 239 DP F N ++D +TV +D P+L+ +R+ R E GE Sbjct: 189 KDPATIFVTGNTAIDALKTTVQKDYHH--PILENLGDNRLILMTAHRREN------LGEP 240 Query: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTI 269 + +FE V++ E+ ++VY +++ + Sbjct: 241 MQGMFEAVREIVESREDTELVYPMHLNPAV 270 >3DIN-A nrPDB Length = 871 Score = 30.5 bits (67), Expect = 3.2, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 4/99 (4%) Query: 160 LLKCFDSPWTTRALSETVVEESDP--KPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKS 217 LL+ F S + ++ +EE P P SK+ ++ KK ++ + T+ + Sbjct: 590 LLRIFGSEQIGKVMNILKIEEGQPIQHPMLSKLIENIQKKVEGINFSIRKTLMEMDDVLD 649 Query: 218 RIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256 + + + + +L+K E K +FE V T VEE Sbjct: 650 KQRRAVYSLRDQILLEKDYDEYLKDIFEDV--VSTRVEE 686 >2FJI-1 nrPDB Length = 399 Score = 29.7 bits (65), Expect = 6.0, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 29/45 (64%) Query: 370 NDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLD 414 N ++ +++++ L +KR ++S++SE +Q+N N+++ +D Sbjct: 77 NQAKILVGVVERFSDLLTKRQKNWISKISEEIKKQINYNHKYDID 121 >5YFP-C nrPDB Length = 805 Score = 29.3 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 29/45 (64%) Query: 370 NDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLD 414 N ++ +++++ L +KR ++S++SE +Q+N N+++ +D Sbjct: 483 NQAKILVGVVERFSDLLTKRQKNWISKISEEIKKQINYNHKYDID 527 >1GVH-A nrPDB Length = 396 Score = 29.3 bits (64), Expect = 7.1, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 31/60 (51%), Gaps = 9/60 (15%) Query: 205 VEATVPMLQRTKSRIEQGIVDRSET---------GVLDKKEGEQAKALFEKVKKFRTHVE 255 V+AT+P+L T ++ DR T + +++ G+Q +ALF + + +++E Sbjct: 10 VKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNAIAAYASNIE 69 >6MDV-A nrPDB Length = 802 Score = 29.3 bits (64), Expect = 7.6, Method: Composition-based stats. Identities = 12/94 (12%), Positives = 38/94 (40%), Gaps = 12/94 (12%) Query: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVG-----------VHLQKLSINNEGTKLIVLN 585 ++ L +L++L++ +L + P+++ + L+KL+++ + + Sbjct: 396 LEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTGLEKLNLSGLNRQTLDGI 455 Query: 586 SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEI 619 + + +LT ++ L + L + Sbjct: 456 DVNSITHLTSFDISHNSL-DLSEKSEDRKLLMTL 488 >1LNS-A nrPDB Length = 763 Score = 28.9 bits (63), Expect = 8.6, Method: Composition-based stats. Identities = 39/206 (18%), Positives = 71/206 (34%), Gaps = 26/206 (12%) Query: 386 YSKRFAVFLSEVSENKLRQLNLNNEWTLD-KLRQRLTKNAQDKLELHLFMLSGIPDTVFD 444 YSK F VF ++ ENK NE +D +L LT N +LEL L + Sbjct: 582 YSKDFNVFKKDLFENKA------NEAVIDLELPSMLTINGPVELELRLKLNDTKGFLSAQ 635 Query: 445 LVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTD 504 +++ K ++ K L + L + + + FT+ Sbjct: 636 ILDFGQKKRLEDK--------VRVKDFKVLDRGRNFMLDDLVELPLVESPYQLVTKGFTN 687 Query: 505 IKEIP-LWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVT 563 ++ L + LK E + L + L++ LR+ + V Sbjct: 688 LQNQSLLTVSDLKADEWFTIKFELQPT---------IYHLEKADKLRVILYSTDFEHTVR 738 Query: 564 DVGVHLQKLSINNEGTKLIVLNSLKK 589 D ++ ++ +I + S+K Sbjct: 739 DNRKVTYEIDLSQSKL-IIPIESVKN 763 >5A08-A nrPDB Length = 434 Score = 28.9 bits (63), Expect = 8.9, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 44/104 (42%), Gaps = 14/104 (13%) Query: 101 LDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFL----ACSNFW-------FKFPRT 149 + + Y + Y N +++K F + LL ++ NF+ F+F Sbjct: 192 MSKENIQYAEVESYHNMCRFYSKEFYHHPLLSKYKYVWRLEPNVNFYCKINYDVFQFMNK 251 Query: 150 SSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGS 193 + K+ FV L +DSP T L + ++ + P + +NG+ Sbjct: 252 NDKIYGFV---LNLYDSPQTIETLWTSTMDFVEEHPNYLNVNGA 292 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.318 0.130 0.358 Lambda K H 0.267 0.0399 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,220,748 Number of Sequences: 36641 Number of extensions: 1160806 Number of successful extensions: 5275 Number of sequences better than 10.0: 81 Number of HSP's better than 10.0 without gapping: 64 Number of HSP's successfully gapped in prelim test: 79 Number of HSP's that attempted gapping in prelim test: 3045 Number of HSP's gapped (non-prelim): 462 length of query: 810 length of database: 10,336,785 effective HSP length: 105 effective length of query: 705 effective length of database: 6,489,480 effective search space: 4575083400 effective search space used: 4575083400 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 63 (28.9 bits)