BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q7Z4W1 (244 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3D3W-A nrPDB 496 e-141 1CYD-A nrPDB 340 4e-94 4EGF-A nrPDB 162 9e-41 1K2W-A nrPDB 123 6e-29 4MOW-A nrPDB 121 2e-28 4HP8-A nrPDB 121 3e-28 4E6P-A nrPDB 118 2e-27 5U9P-A nrPDB 117 4e-27 4Z9Y-A nrPDB 115 1e-26 3UN1-A nrPDB 115 2e-26 2AE2-A nrPDB 111 3e-25 5ITV-A nrPDB 110 4e-25 3UF0-A nrPDB 109 8e-25 4AVY-A nrPDB 109 9e-25 3O4R-A nrPDB 109 1e-24 5VT6-A nrPDB 108 2e-24 4M8S-A nrPDB 107 7e-24 1Q7C-A nrPDB 105 3e-23 2C07-A nrPDB 104 3e-23 1AE1-A nrPDB 104 4e-23 2PNF-A nrPDB 103 6e-23 2UVD-A nrPDB 103 6e-23 3FTP-A nrPDB 103 8e-23 4IIN-A nrPDB 102 2e-22 4JRO-A nrPDB 102 2e-22 3RSH-A nrPDB 101 2e-22 5OJG-A nrPDB 101 3e-22 4CR6-A nrPDB 101 3e-22 2ZAT-A nrPDB 101 3e-22 3F9I-A nrPDB 100 6e-22 2NM0-A nrPDB 100 6e-22 3OSU-A nrPDB 100 9e-22 2HQ1-A nrPDB 99 1e-21 5T5Q-A nrPDB 99 1e-21 6CI9-A nrPDB 99 1e-21 4NBT-A nrPDB 99 2e-21 3WOH-A nrPDB 98 3e-21 4CQL-A nrPDB 98 3e-21 3EZL-A nrPDB 97 4e-21 3EMK-A nrPDB 97 5e-21 4K6F-A nrPDB 97 7e-21 1GEG-A nrPDB 95 2e-20 4KMS-A nrPDB 95 2e-20 4GKB-A nrPDB 95 3e-20 3OIC-A nrPDB 92 1e-19 2EW8-A nrPDB 91 4e-19 3V2G-A nrPDB 91 4e-19 4BO1-A nrPDB 91 5e-19 2FWM-X nrPDB 91 5e-19 1AHH-A nrPDB 91 6e-19 3LYL-A nrPDB 91 7e-19 3VZS-A nrPDB 90 7e-19 1UZM-A nrPDB 89 2e-18 1GEE-A nrPDB 89 2e-18 3OEC-A nrPDB 89 2e-18 3A28-C nrPDB 88 3e-18 5OVJ-A nrPDB 87 7e-18 5OVL-A nrPDB 87 8e-18 2CFC-A nrPDB 87 8e-18 2Q2Q-A nrPDB 86 1e-17 1DOH-A nrPDB 86 1e-17 5CDY-A nrPDB 86 1e-17 3T7C-A nrPDB 86 1e-17 2PH3-A nrPDB 86 2e-17 2HSD-A nrPDB 85 2e-17 3RWB-A nrPDB 85 3e-17 5EJ2-A nrPDB 85 3e-17 3WYE-A nrPDB 85 4e-17 1H5Q-A nrPDB 84 4e-17 4FC7-A nrPDB 84 5e-17 3AUT-A nrPDB 84 6e-17 5B1Y-A nrPDB 84 6e-17 1NFF-A nrPDB 84 7e-17 3GRP-A nrPDB 83 1e-16 4NBV-A nrPDB 82 2e-16 4CQM-B nrPDB 82 2e-16 3V8B-A nrPDB 82 3e-16 3WTC-A nrPDB 82 3e-16 5YSS-A nrPDB 81 4e-16 4RZH-A nrPDB 81 5e-16 4DBZ-A nrPDB 80 6e-16 2AG5-A nrPDB 80 6e-16 4DMM-A nrPDB 80 1e-15 2B4Q-A nrPDB 79 1e-15 4RZI-B nrPDB 79 2e-15 1O5I-A nrPDB 78 5e-15 4IS3-A nrPDB 77 9e-15 3UVE-A nrPDB 77 9e-15 2BFA-A nrPDB 76 1e-14 2QHX-A nrPDB 76 1e-14 2X9N-A nrPDB 75 3e-14 4RGB-A nrPDB 74 4e-14 4IIV-A nrPDB 74 5e-14 2CDH-G nrPDB 74 7e-14 1X1T-A nrPDB 74 8e-14 3W8F-A nrPDB 74 8e-14 4DA9-A nrPDB 73 1e-13 5O3Z-A nrPDB 73 1e-13 1HXH-A nrPDB 72 2e-13 3ZV3-A nrPDB 71 5e-13 3V2H-A nrPDB 70 9e-13 4JQC-A nrPDB 70 1e-12 5CFZ-A nrPDB 69 1e-12 6NRP-A nrPDB 69 1e-12 4M89-A nrPDB 69 2e-12 1YXM-A nrPDB 69 3e-12 1BDB-A nrPDB 68 3e-12 5JS6-A nrPDB 68 5e-12 1P33-A nrPDB 65 2e-11 2P91-A nrPDB 65 3e-11 4ALL-A nrPDB 64 4e-11 3U5T-A nrPDB 64 4e-11 2BGM-A nrPDB 63 9e-11 5TF4-A nrPDB 63 1e-10 4J3F-A nrPDB 63 1e-10 2PD3-A nrPDB 62 2e-10 3RKU-A nrPDB 62 3e-10 4NK4-A nrPDB 61 4e-10 5JY1-A nrPDB 61 6e-10 3OIG-A nrPDB 60 8e-10 3UCF-A nrPDB 60 1e-09 5YCX-A nrPDB 59 1e-09 1FJH-A nrPDB 59 1e-09 5KOI-A nrPDB 59 2e-09 1W73-A nrPDB 59 2e-09 4ZJU-A nrPDB 59 3e-09 2GDZ-A nrPDB 58 3e-09 3R3S-A nrPDB 58 4e-09 2YW9-A nrPDB 58 5e-09 3K2E-A nrPDB 58 5e-09 4TRR-A nrPDB 57 6e-09 2O23-A nrPDB 57 7e-09 3GRK-A nrPDB 56 1e-08 2DKN-A nrPDB 55 2e-08 3GDF-A nrPDB 55 3e-08 3U4C-A nrPDB 55 3e-08 3PXX-A nrPDB 54 8e-08 5I9N-A nrPDB 53 1e-07 3DWF-A nrPDB 52 3e-07 3KZV-A nrPDB 51 4e-07 4DRY-A nrPDB 50 7e-07 1A27-A nrPDB 50 7e-07 1OAA-A nrPDB 50 7e-07 2NWQ-A nrPDB 50 8e-07 6CGE-A nrPDB 50 1e-06 4Z3K-A nrPDB 49 1e-06 4HWK-A nrPDB 49 2e-06 5IZ4-A nrPDB 49 3e-06 1ENP-A nrPDB 48 5e-06 4HBG-A nrPDB 47 7e-06 5PGZ-A nrPDB 47 8e-06 1E3W-A nrPDB 47 9e-06 5WQO-A nrPDB 45 3e-05 3U9L-A nrPDB 45 4e-05 3OML-A nrPDB 43 1e-04 5ILO-A nrPDB 42 3e-04 3PPI-A nrPDB 40 7e-04 1SNY-A nrPDB 40 7e-04 3E9N-A nrPDB 40 0.001 4Q9N-A nrPDB 39 0.002 2VN8-A nrPDB 39 0.003 2HRB-A nrPDB 38 0.005 5TQV-A nrPDB 37 0.007 5K1S-A nrPDB 37 0.010 1N5D-A nrPDB 36 0.015 2PTG-A nrPDB 36 0.017 3BHI-A nrPDB 35 0.033 4OMU-A nrPDB 32 0.19 4J6F-A nrPDB 32 0.21 5JXW-A nrPDB 32 0.23 4N7R-A nrPDB 32 0.24 5LCX-A nrPDB 32 0.32 1FZE-A nrPDB 31 0.47 4OYR-A nrPDB 31 0.54 3O26-A nrPDB 30 0.91 2NTV-A nrPDB 30 1.1 3H32-A nrPDB 30 1.1 6EHL-A nrPDB 30 1.2 6APH-A nrPDB 30 1.2 1O89-A nrPDB 29 1.5 3F4B-A nrPDB 29 1.8 3NJ4-A nrPDB 29 1.9 5L51-A nrPDB 29 1.9 2ZJ1-A nrPDB 29 1.9 4ZTI-A nrPDB 29 2.1 2HK7-A nrPDB 29 2.2 4Z9P-A nrPDB 29 2.3 3AOE-A nrPDB 28 2.7 5Z9W-A nrPDB 28 3.0 3G1U-A nrPDB 28 3.1 6C54-A nrPDB 28 3.5 3GHG-A nrPDB 28 3.6 3RFT-A nrPDB 28 5.3 2EGG-A nrPDB 27 5.5 3N58-A nrPDB 27 5.8 6GBN-A nrPDB 27 6.6 4F35-D nrPDB 27 7.3 >3D3W-A nrPDB Length = 244 Score = 496 bits (1278), Expect = e-141, Method: Compositional matrix adjust. Identities = 244/244 (100%), Positives = 244/244 (100%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD Sbjct: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR Sbjct: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT Sbjct: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG Sbjct: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 Query: 241 FWAC 244 FWAC Sbjct: 241 FWAC 244 >1CYD-A nrPDB Length = 244 Score = 340 bits (871), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 165/244 (67%), Positives = 197/244 (80%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 M+L +G R LVTGAGKGIGR TV+ALHA+GA+VVAV+RT +DL SL +ECPGIEPVCVD Sbjct: 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVD 60 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 LGDW+ATE+ALG +GPVDLLVNNAA+ ++QPFLEVTKEAFDRSF VNLR+V QVSQ+VAR Sbjct: 61 LGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVAR 120 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 +I RGVPG+IVNVSS + N Y STKGA+ MLTK MA+ELGPHKIRVN+VNPT Sbjct: 121 DMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNPT 180 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 VV+T MG+ +DP A+ + R PL KFAEVE VVN+ILFLLSDRS T+G + V+ G Sbjct: 181 VVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSGGGILVDAG 240 Query: 241 FWAC 244 + A Sbjct: 241 YLAS 244 >4EGF-A nrPDB Length = 266 Score = 162 bits (411), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 101/248 (40%), Positives = 147/248 (59%), Gaps = 9/248 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PGIEPV 57 L L G+R L+TGA KGIG +A A GAR+V R ++LD+ R + V Sbjct: 16 LRLDGKRALITGATKGIGADIARAFAAAGARLVLSGRDVSELDAARRALGEQFGTDVHTV 75 Query: 58 CVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 +DL + +A RA + G +D+LVNNA ++ QP ++ + FD + VNLRA Sbjct: 76 AIDLAEPDAPAELARRAAEAFGGLDVLVNNAGISHPQPVVDTDPQLFDATIAVNLRAPAL 135 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ V + ++A G GAI+ V+S + + +H YC++K L M TKV+A ELGPH IR Sbjct: 136 LASAVGKAMVAAGEGGAIITVASAAALAPLPDHYAYCTSKAGLVMATKVLARELGPHGIR 195 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N+V PTVV+T MGQ W D K+ M+ RIPLG+FA V +A+++L SD + M G Sbjct: 196 ANSVCPTVVLTEMGQRVWGDEAKSAPMIARIPLGRFAVPHEVSDAVVWLASDAASMINGV 255 Query: 234 TLPVEGGF 241 +PV+GG+ Sbjct: 256 DIPVDGGY 263 >1K2W-A nrPDB Length = 256 Score = 123 bits (309), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 81/252 (32%), Positives = 128/252 (50%), Gaps = 14/252 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G+ L+TG+ +GIGR +A GARV +A +A + P + +D+ D Sbjct: 3 LDGKTALITGSARGIGRAFAEAYVREGARVAIADINLEAARATAAEIGPAACAIALDVTD 62 Query: 64 WEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 + +R + + G +D+LVNNAA+ L P +E+T+E++DR F +N+ + + Q VA Sbjct: 63 QASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLFMMQAVA 122 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 R +IA G G I+N++SQ +R VYC+TK A+ LT+ L L H I VNA+ P Sbjct: 123 RAMIAGGRGGKIINMASQAGRRGEALVGVYCATKAAVISLTQSAGLNLIRHGINVNAIAP 182 Query: 180 TVVMTSMG---QATWSDP------HKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 VV A ++D K + + +P G+ E + +FL + + Sbjct: 183 GVVDGEHWDGVDAKFADYENLPRGEKKRQVGAAVPFGRMGRAEDLTGMAIFLATPEADYI 242 Query: 231 TGSTLPVEGGFW 242 T V+GG W Sbjct: 243 VAQTYNVDGGNW 254 >4MOW-A nrPDB Length = 256 Score = 121 bits (304), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 91/250 (36%), Positives = 132/250 (52%), Gaps = 19/250 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV---AVSRTQAD-LDSLVRECPGIEPVCV- 59 LAG+ +VTGA KGIG +AL GA VV A S+ AD + S + E G V V Sbjct: 12 LAGKVAIVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGG-RAVAVG 70 Query: 60 -DLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ +R A+ + G +D+LVNN+ V P +T+E + R F+ N+ V+ Sbjct: 71 GDVSKAADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITEEHYRRQFDTNVFGVLLT 130 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 +Q + L G +I+N+SS + +VY TKGA+D +T V+ALELGP KIRV Sbjct: 131 TQAAVKHL---GEGASIINISSVVTSITPPASAVYSGTKGAVDAITGVLALELGPRKIRV 187 Query: 175 NAVNPTVVMTSMGQAT---WSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 NA+NP +++T + SD +L + PLG+ E + + +FL SD + T Sbjct: 188 NAINPGMIVTEGTHSAGIIGSDLE--AQVLGQTPLGRLGEPNDIASVAVFLASDDARWMT 245 Query: 232 GSTLPVEGGF 241 G L V GG Sbjct: 246 GEHLVVSGGL 255 >4HP8-A nrPDB Length = 247 Score = 121 bits (304), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 78/241 (32%), Positives = 125/241 (51%), Gaps = 3/241 (1%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD--LDSLVRECPGIEPVCVDLG 62 L GR+ LVTGA G+G+ L A GA VV +R D LD + ++ + +D Sbjct: 7 LEGRKALVTGANTGLGQAIAVGLAAAGAEVVCAARRAPDETLDIIAKDGGNASALLIDFA 66 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 D A + + G D+LVNNA + +E ++ +D +VNL+A+ +Q A+ L Sbjct: 67 DPLAAKDSFTDAG-FDILVNNAGIIRRADSVEFSELDWDEVMDVNLKALFFTTQAFAKEL 125 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 +A+G G +VN++S S + Y + K + LTK++A E I VNA+ P + Sbjct: 126 LAKGRSGKVVNIASLLSFQGGIRVPSYTAAKHGVAGLTKLLANEWAAKGINVNAIAPGYI 185 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 T+ +A +D + K +L RIP G++ E + A +FL S + G+ L V+GG+ Sbjct: 186 ETNNTEALRADAARNKAILERIPAGRWGHSEDIAGAAVFLSSAAADYVHGAILNVDGGWL 245 Query: 243 A 243 A Sbjct: 246 A 246 >4E6P-A nrPDB Length = 259 Score = 118 bits (295), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 80/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD-SLVREC-----PGIEPVC 58 L G+ L+TG+ +GIGR +A GA V AD+D R+ P V Sbjct: 6 LEGKSALITGSARGIGRAFAEAYVREGATVAI-----ADIDIERARQAAAEIGPAAYAVQ 60 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +D+ ++ + A+ + G +D+LVNNAA+ L P +E+T+E++++ F +N+ + Sbjct: 61 MDVTRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFT 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 Q AR +IA+G G I+N++SQ +R ++YC+TK A+ LT+ L+L H+I V Sbjct: 121 LQAAARQMIAQGRGGKIINMASQAGRRGEALVAIYCATKAAVISLTQSAGLDLIKHRINV 180 Query: 175 NAVNPTVV-------MTSMGQATWSDPHKAKTML--NRIPLGKFAEVEHVVNAILFLLSD 225 NA+ P VV + ++ + P K L +P G+ E + +FL S Sbjct: 181 NAIAPGVVDGEHWDGVDALFARYENRPRGEKKRLVGEAVPFGRMGTAEDLTGMAIFLASA 240 Query: 226 RSGMTTGSTLPVEGGFW 242 S T V+GG W Sbjct: 241 ESDYIVSQTYNVDGGNW 257 >5U9P-A nrPDB Length = 265 Score = 117 bits (293), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 81/246 (32%), Positives = 118/246 (47%), Gaps = 11/246 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L GRR L+TG+G+GIG + L GA +V R + +L R E D + Sbjct: 18 LDGRRALITGSGRGIGLTLARGLAEAGAAIVINDRNEEKAATLARRFRD-EGFAADHAVF 76 Query: 65 EATERAL---------GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 + E A VG +D+LVNNA + P + + VNL V V+ Sbjct: 77 DVAEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMRVNLDGVFNVA 136 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 Q VAR +IARG G I+N+ S S+ A + Y +TKGA+ MLTK M + + I+ N Sbjct: 137 QAVARHMIARG-HGKIINICSVQSELARPTIAPYAATKGAVRMLTKGMCADWARYGIQAN 195 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 + P T + +A D + + R P G++ +V+ + A +FL S S G TL Sbjct: 196 GLAPGYFETELNRALVDDAAFSDWLCKRTPAGRWGQVDELCGAAIFLASAASDFVNGQTL 255 Query: 236 PVEGGF 241 V+GG Sbjct: 256 FVDGGL 261 >4Z9Y-A nrPDB Length = 253 Score = 115 bits (289), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 75/245 (30%), Positives = 129/245 (52%), Gaps = 6/245 (2%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-----RTQADLDSLVRECPGIEPVCV 59 L G+ L+TG G+G+G L G +V V+ T + +L R + Sbjct: 8 LQGKVALITGCDTGLGQGMAIGLAQAGCDIVGVNIVEPKDTIEKVTALGRRFLSLTADMS 67 Query: 60 DL-GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 ++ G E E+A+ G VD+LVNNA + + +E +++ +D +N+++V +SQ V Sbjct: 68 NVSGHAELVEKAVAEFGHVDILVNNAGIIRREDAIEFSEKNWDDVMNLNIKSVFFMSQTV 127 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 AR I +G G I+N++S S + Y ++K A+ +T++MA E H I VNA+ Sbjct: 128 ARQFIKQGKGGKIINIASMLSFQGGIRVPSYTASKSAVMGVTRLMANEWAKHGINVNAIA 187 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P + T+ Q +D ++K +L+RIP G++ + ++ +FL S S G T+ V+ Sbjct: 188 PGYMATNNTQQLRADEERSKEILDRIPAGRWGLPQDLMGPSVFLASSASDYINGYTIAVD 247 Query: 239 GGFWA 243 GG+ A Sbjct: 248 GGWLA 252 >3UN1-A nrPDB Length = 260 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 86/240 (35%), Positives = 129/240 (53%), Gaps = 25/240 (10%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRT---QADLDSLVRECPGIEPVCVDLGDWEA 66 V++TGA +GIG G V+A RVVA SR+ AD P I V D+ E Sbjct: 31 VVITGASQGIGAGLVRAYRDRNYRVVATSRSIKPSAD--------PDIHTVAGDISKPET 82 Query: 67 TER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 +R + G +D LVNNA V L +PF+E+T+E +D + VN+ ++Q A + Sbjct: 83 ADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFHITQRAAAEM 142 Query: 123 IARGVPGAIVNV-SSQCSQRAVTNHSVYCS-TKGALDMLTKVMALELGPHKIRVNAVNPT 180 + +G G IV++ +S Q V S S TKG L+ +T+ +A+E +RVNAV+P Sbjct: 143 LKQG-SGHIVSITTSLVDQPMVGMPSALASLTKGGLNAVTRSLAMEFSRSGVRVNAVSPG 201 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 V+ T M A + H L+ P+G+ E+ VV+A+L+L + +G TG L V+GG Sbjct: 202 VIKTPMHPA---ETHSTLAGLH--PVGRMGEIRDVVDAVLYL--EHAGFITGEILHVDGG 254 >2AE2-A nrPDB Length = 260 Score = 111 bits (277), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 75/251 (29%), Positives = 121/251 (48%), Gaps = 13/251 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 L G LVTG +GIG G V+ L + GA V SR Q +L+ + + +E D Sbjct: 7 LEGCTALVTGGSRGIGYGIVEELASLGASVYTCSRNQKELNDCLTQWRSKGFKVEASVCD 66 Query: 61 LGDWEATERALGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 L + + +V G +++LVNNA + + + + T E + +N A +S Sbjct: 67 LSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYHLS 126 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 ++A + G +V +SS AV +VY +TKGA+D LT+ +A E IRVN Sbjct: 127 -VLAHPFLKASERGNVVFISSVSGALAVPYEAVYGATKGAMDQLTRCLAFEWAKDNIRVN 185 Query: 176 AVNPTVVMTSMGQATWSDPHKAKT---MLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 V P V+ TS+ + T DP + + +++R L + E + + + FL + TG Sbjct: 186 GVGPGVIATSLVEMTIQDPEQKENLNKLIDRCALRRMGEPKELAAMVAFLCFPAASYVTG 245 Query: 233 STLPVEGGFWA 243 + V+GG A Sbjct: 246 QIIYVDGGLMA 256 >5ITV-A nrPDB Length = 255 Score = 110 bits (276), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 79/257 (30%), Positives = 129/257 (50%), Gaps = 17/257 (6%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG--IEPVC 58 M + L + VL+TG GIG VQA A VV +A +++VR+ + V Sbjct: 1 MIMNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQ 60 Query: 59 VDLGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ D A E A+ + G +D+L+NNA + ++ P E+ +++ +VNL + + Sbjct: 61 TDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLM 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ + ++A G G I+N S A + Y ++KG + LTK MA++ H+IRV Sbjct: 121 SKHALKHMLAAG-KGNIINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDYAKHQIRV 179 Query: 175 NAVNPTVVMTSM--------GQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDR 226 N V P ++ T + + T + K K +N PL + + E + N +LFL SD Sbjct: 180 NCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVN--PLLRLGKPEEIANVMLFLASDL 237 Query: 227 SGMTTGSTLPVEGGFWA 243 S TGS + +GG+ A Sbjct: 238 SSYMTGSAITADGGYTA 254 >3UF0-A nrPDB Length = 273 Score = 109 bits (273), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 83/246 (33%), Positives = 119/246 (48%), Gaps = 7/246 (2%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT---QADLDSLVRECPGIEPVCVDL 61 LAGR +VTGAG GIGR GA V+A RT + D + E V DL Sbjct: 29 LAGRTAVVTGAGSGIGRAIAHGYARAGAHVLAWGRTDGVKEVADEIADGGGSAEAVVADL 88 Query: 62 GDWEATE---RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D E L + VD+LVNNA + P EV+ + VNL A +S+ Sbjct: 89 ADLEGAANVAEELAATRRVDVLVNNAGIIARAPAEEVSLGRWREVLTVNLDAAWVLSRSF 148 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 ++A G G IV ++S S + N + Y ++K A+ LT+ +A E + VNA+ Sbjct: 149 GTAMLAHG-SGRIVTIASMLSFQGGRNVAAYAASKHAVVGLTRALASEWAGRGVGVNALA 207 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P V+T+ A +D +A + RIP G++A E +V +FL SD + G L V+ Sbjct: 208 PGYVVTANTAALRADDERAAEITARIPAGRWATPEDMVGPAVFLASDAASYVHGQVLAVD 267 Query: 239 GGFWAC 244 GG+ A Sbjct: 268 GGWLAS 273 >4AVY-A nrPDB Length = 242 Score = 109 bits (273), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 75/237 (31%), Positives = 119/237 (50%), Gaps = 8/237 (3%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-VRECPGIEPVCVDLGDW 64 AG++VLVTG GIG GA VVA+ D D + P I +D+ D Sbjct: 10 AGQQVLVTGGSSGIGAAIAMQFAELGAEVVALG---LDADGVHAPRHPRIRREELDITDS 66 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 + +R ++ +D+LVNNA ++ + E F+R +NL A + SQ+ L Sbjct: 67 QRLQRLFEALPRLDVLVNNAGISRDRE--EYDLATFERVLRLNLSAAMLASQLARPLLAQ 124 Query: 125 RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMT 184 RG G+I+N++S S + Y ++KGA+ LT+ +A E +IRVNA+ P + T Sbjct: 125 RG--GSILNIASMYSTFGSADRPAYSASKGAIVQLTRSLACEYAAERIRVNAIAPGWIDT 182 Query: 185 SMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 +G +D + ++ R PL ++ E V +A FL + TG+ L V+GG+ Sbjct: 183 PLGAGLKADVEATRRIMQRTPLARWGEAPEVASAAAFLCGPGASFVTGAVLAVDGGY 239 >3O4R-A nrPDB Length = 261 Score = 109 bits (272), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 81/248 (32%), Positives = 126/248 (50%), Gaps = 16/248 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 LA + LVT + GIG + L GA VV SR Q ++D V G + Sbjct: 13 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 72 Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRAVI 112 +G E ER + + G +D+LV+NAAV PF ++VT+E +D++ ++N++A Sbjct: 73 VGKAEDRERLVATAVKLHGGIDILVSNAAV---NPFFGSIMDVTEEVWDKTLDINVKAPA 129 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 +++ V + RG G++V VSS + S Y +K AL LTK +A+EL P I Sbjct: 130 LMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNI 188 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 RVN + P ++ TS + W D K ++M + + + E E + FL S+ + TG Sbjct: 189 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITG 248 Query: 233 STLPVEGG 240 T+ V GG Sbjct: 249 ETVVVGGG 256 >5VT6-A nrPDB Length = 269 Score = 108 bits (269), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 79/244 (32%), Positives = 117/244 (47%), Gaps = 11/244 (4%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS--LVRECPG---IEPVCVD 60 A R VTG G+G + LH G V + D S L+ E + VD Sbjct: 24 AKRVAFVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVD 83 Query: 61 LGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + D+E+ ER L G VD+L+NNA + F+++TK +D +L A+ V++ Sbjct: 84 VADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVTK 143 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 G++ R G IVN+ S R + Y S K + TK +ALE I VN Sbjct: 144 QFIAGMVERRF-GRIVNIGSVNGSRGAFGQANYASAKAGIHGFTKTLALETAKRGITVNT 202 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 V+P + T+M +A D +AK +L +IP+G+ + V I FL SD +G TG+ L Sbjct: 203 VSPGYLATAMVEAVPQDVLEAK-ILPQIPVGRLGRPDEVAALIAFLCSDDAGFVTGADLA 261 Query: 237 VEGG 240 + GG Sbjct: 262 INGG 265 >4M8S-A nrPDB Length = 248 Score = 107 bits (266), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 73/243 (30%), Positives = 124/243 (51%), Gaps = 9/243 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP--GIEPVCVDLG 62 L+G+ LVTGA +GIG L A GA+V+ + +++ ++ G E ++ Sbjct: 6 LSGKIALVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGGEGRVLNSA 65 Query: 63 DWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + E E + + G +D+LVNNA + + + +E +D +VNL++V + S+ V Sbjct: 66 EPETVENLIADIEKTFGKLDILVNNAGITRDNLLMRMKEEEWDDIMQVNLKSVFRASKAV 125 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 RG++ + G I+N++S + Y + K L +K MA E+G I VN V Sbjct: 126 LRGMMKQ-RAGRIINITSVVGVMGNAGQTNYAAAKAGLIGFSKSMAREVGSRGITVNCVA 184 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P + T M +A + + T + LG+F + + + +A+LFL SD++ TG TL V Sbjct: 185 PGFIDTDMTRALPEETRQ--TFTAQTALGRFGDAQDIADAVLFLASDQAKYITGQTLHVN 242 Query: 239 GGF 241 GG Sbjct: 243 GGM 245 >1Q7C-A nrPDB Length = 244 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 74/241 (30%), Positives = 117/241 (48%), Gaps = 8/241 (3%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT----QADLDSLVRECPGIEPVCVDLG 62 G+ LVTGA +GIGR + L A GA+V+ + + QA D L G+ D Sbjct: 5 GKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNVTDPA 64 Query: 63 DWEAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 E+ E+ G VD+LVNNA + + + E ++ E NL +V ++S+ V R Sbjct: 65 SIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMRA 124 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 ++ + G I+ + S + + + K L +K +A E+ I VN V P Sbjct: 125 MMKK-RHGRIITIGSVVGTMGNGGQANFAAAKAGLIGFSKSLAREVASRGITVNVVAPGF 183 Query: 182 VMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + T M +A SD +A +L ++P G+ + + NA+ FL SD + TG TL V GG Sbjct: 184 IETDMTRA-LSDDQRAG-ILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVNGGM 241 Query: 242 W 242 + Sbjct: 242 Y 242 >2C07-A nrPDB Length = 285 Score = 104 bits (260), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 72/239 (30%), Positives = 112/239 (46%), Gaps = 11/239 (4%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP--GIEP--VCVDLGDWEA 66 LVTGAG+GIGR + L + + V+ +SRTQ DS+V E G E D+ E Sbjct: 48 LVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSKKEE 107 Query: 67 TERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 + + VD+LVNNA + FL + + ++ NL ++ ++Q +++ + Sbjct: 108 ISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPISKRM 167 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 I G I+N+SS + Y S+K + TK +A EL I VNA+ P + Sbjct: 168 INNRY-GRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPGFI 226 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + M K +++ IP G+ E V N FL SD+SG G ++GG Sbjct: 227 SSDMTDKI--SEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGL 283 >1AE1-A nrPDB Length = 273 Score = 104 bits (259), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 127/252 (50%), Gaps = 14/252 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR----ECPGIEPVCVD 60 L G LVTG KGIG V+ L GARV SR + +LD + + +E D Sbjct: 19 LKGTTALVTGGSKGIGYAIVEELAGLGARVYTCSRNEKELDECLEIWREKGLNVEGSVCD 78 Query: 61 LGDWEATERALGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 L ++ + +V G +++LVNNA V + + + T++ ++ N A +S Sbjct: 79 LLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAYHLS 138 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 QI A L+ G ++ +SS A+ + S+Y ++KGA++ +TK +A E IRVN Sbjct: 139 QI-AYPLLKASQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACEWAKDNIRVN 197 Query: 176 AVNPTVVMTSMGQ-ATWSDPHKAKTMLNRI---PLGKFAEVEHVVNAILFLLSDRSGMTT 231 +V P V++T + + A +PH+ + + N I P+G+ + + V I FL + T Sbjct: 198 SVAPGVILTPLVETAIKKNPHQKEEIDNFIVKTPMGRAGKPQEVSALIAFLCFPAASYIT 257 Query: 232 GSTLPVEGGFWA 243 G + +GGF A Sbjct: 258 GQIIWADGGFTA 269 >2PNF-A nrPDB Length = 248 Score = 103 bits (258), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 80/251 (31%), Positives = 121/251 (48%), Gaps = 12/251 (4%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP---GIEPV 57 ME+ L G+ LVTG+ +GIGR + L + G+ V+ + ++ E G++ Sbjct: 1 MEIKLQGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAH 60 Query: 58 CVDLGDW------EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 V++ +A E V +D+LVNNA + + FL ++ ++ +VNL Sbjct: 61 GVEMNLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGT 120 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 V+Q R +I + G IVN+SS Y +TK L TK +A EL P Sbjct: 121 FLVTQNSLRKMIKQR-WGRIVNISSVVGFTGNVGQVNYSTTKAGLIGFTKSLAKELAPRN 179 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 + VNAV P + T M A S+ K K +IPLG+F E V N +LFL S+ + T Sbjct: 180 VLVNAVAPGFIETDM-TAVLSEEIKQKYK-EQIPLGRFGSPEEVANVVLFLCSELASYIT 237 Query: 232 GSTLPVEGGFW 242 G + V GG + Sbjct: 238 GEVIHVNGGMF 248 >2UVD-A nrPDB Length = 246 Score = 103 bits (257), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 79/247 (31%), Positives = 116/247 (46%), Gaps = 12/247 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVA-VSRTQADLDSLVRECP--GIEPVCV- 59 L G+ LVTGA +GIGR L GA VV + + + +V E G + + V Sbjct: 1 MLKGKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVR 60 Query: 60 -DLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + E ++ + G VD+LVNNA V + + +E +D NL+ V Sbjct: 61 ADVANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVFLC 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 ++ V+R + R G IVN++S + Y + K + LTK A EL I V Sbjct: 121 TKAVSR-FMMRQRHGRIVNIASVVGVTGNPGQANYVAAKAGVIGLTKTSAKELASRNITV 179 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 NA+ P + T M D + ML IP +F E + + NA+ F SD+S TG T Sbjct: 180 NAIAPGFIATDMTDVL--DENIKAEMLKLIPAAQFGEAQDIANAVTFFASDQSKYITGQT 237 Query: 235 LPVEGGF 241 L V+GG Sbjct: 238 LNVDGGM 244 >3FTP-A nrPDB Length = 270 Score = 103 bits (256), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 80/252 (31%), Positives = 127/252 (50%), Gaps = 15/252 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL--VRECPGIEPVC 58 M+ L + +VTGA +GIGR L GA V+ + T+A + + + G+E Sbjct: 22 MDKTLDKQVAIVTGASRGIGRAIALELARRGAMVIGTATTEAGAEGIGAAFKQAGLEGRG 81 Query: 59 VDLGDWEAT------ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 L +AT E L G +++LVNNA + Q + + + +D + NL+AV Sbjct: 82 AVLNVNDATAVDALVESTLKEFGALNVLVNNAGITQDQLAMRMKDDEWDAVIDTNLKAVF 141 Query: 113 QVSQIVARGLI-ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 ++S+ V R ++ ARG G IVN++S Y + K + +T+ +A E+G Sbjct: 142 RLSRAVLRPMMKARG--GRIVNITSVVGSAGNPGQVNYAAAKAGVAGMTRALAREIGSRG 199 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLN-RIPLGKFAEVEHVVNAILFLLSDRSGMT 230 I VN V P + T M T P + +T L +IPLG+ E + +A+ FL S ++G Sbjct: 200 ITVNCVAPGFIDTDM---TKGLPQEQQTALKTQIPLGRLGSPEDIAHAVAFLASPQAGYI 256 Query: 231 TGSTLPVEGGFW 242 TG+TL V GG + Sbjct: 257 TGTTLHVNGGMF 268 >4IIN-A nrPDB Length = 271 Score = 102 bits (253), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 77/247 (31%), Positives = 120/247 (48%), Gaps = 12/247 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL-DSLVREC--PGIEPVCVDL 61 G+ VL+TGA KGIG + L + G +V R+ A++ D+L E G + + Sbjct: 27 FTGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKF 86 Query: 62 -----GDW-EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ EA + + S G + LVNNA V + +++ E F + NL + + Sbjct: 87 DAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAF-IG 145 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 A ++++ G++VNV+S +R + Y ++KG + ++K A E IR N Sbjct: 146 CREALKVMSKSRFGSVVNVASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGALRNIRFN 205 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 +V P + T M A D KA + N IPL + + V A+ FLLSD S TG TL Sbjct: 206 SVTPGFIETDM-NANLKDELKADYVKN-IPLNRLGSAKEVAEAVAFLLSDHSSYITGETL 263 Query: 236 PVEGGFW 242 V GG + Sbjct: 264 KVNGGLY 270 >4JRO-A nrPDB Length = 271 Score = 102 bits (253), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/246 (30%), Positives = 115/246 (46%), Gaps = 12/246 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV--------AVSRTQADLDSLVRECPGIEP 56 L G+ +VTG +GIGR L GA + A T + E ++ Sbjct: 27 LQGKVAVVTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLVAEHGVEVEAMKA 86 Query: 57 VCVDLGDWEAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D +A ++A+ G VD+LVNNA + + + ++ +D +NL+ + Sbjct: 87 NVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDEWDDVININLKGTFLCT 146 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V+R ++ + G I+N++S + Y ++K + LTK A EL P I VN Sbjct: 147 KAVSRTMMKQ-RAGKIINMASVVGLIGNAGQANYVASKAGVIGLTKTTARELAPRGINVN 205 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 AV P + T M D + ML +IPLG + E + NA+LFL SD S TG TL Sbjct: 206 AVAPGFITTDMTDKL--DEKTKEAMLAQIPLGAYGTTEDIANAVLFLASDASKYITGQTL 263 Query: 236 PVEGGF 241 V+GG Sbjct: 264 SVDGGM 269 >3RSH-A nrPDB Length = 251 Score = 101 bits (252), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 74/243 (30%), Positives = 117/243 (48%), Gaps = 8/243 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVD 60 L G+ LVTGA +GIG+ + L GA+V+ S QA D L G+ + Sbjct: 10 LEGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMALNVTN 69 Query: 61 LGDWEATERAL-GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 EA +A+ G VD+LVNNA + + + +E + E NL ++ ++S+ V Sbjct: 70 PESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLSKAVL 129 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 RG++ + G I+NV S + Y + K + TK MA E+ + VN V P Sbjct: 130 RGMMKK-RQGRIINVGSVVGTMGNAGQANYAAAKAGVIGFTKSMAREVASRGVTVNTVAP 188 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 + T M +A +D + T L ++P G+ + + +A+ FL S + TG TL V G Sbjct: 189 GFIETDMTKA-LNDEQRTAT-LAQVPAGRLGDPREIASAVAFLASPEAAYITGETLHVNG 246 Query: 240 GFW 242 G + Sbjct: 247 GMY 249 >5OJG-A nrPDB Length = 260 Score = 101 bits (251), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 120/252 (47%), Gaps = 14/252 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--ECPGIEPVCVDLG 62 G+ +VT A KGIG + L GA VV SR Q ++D + + G+ V G Sbjct: 8 FEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAG 67 Query: 63 DWEATER-------ALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +T+ L G +++LVNN + LEV+ + +D+ FEVN++A Q+ Sbjct: 68 HIASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQM 127 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 +++V IA+ GAI+ +S + ++ + Y TK L LT+ +A+ L IRV Sbjct: 128 TKLV-HPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRV 186 Query: 175 NAVNPTVVMTSMGQATWS---DPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 N + P V+ T M Q W D K T + I LG+ + + +L SD S T Sbjct: 187 NGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYIT 246 Query: 232 GSTLPVEGGFWA 243 G + + GG A Sbjct: 247 GEMIIIAGGVQA 258 >4CR6-A nrPDB Length = 271 Score = 101 bits (251), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 83/249 (33%), Positives = 125/249 (50%), Gaps = 11/249 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 LAG+ +VTGA GIGR TV+A GA VVA+ L + E PG P+ DL D Sbjct: 13 LAGKAAIVTGAAGGIGRATVEAYLREGASVVAMD-LAPRLAATRYEEPGAIPIACDLADR 71 Query: 65 EATERALGS----VGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 A + A+ +G +D+LV A+ FL+++ +DR +VN+ + A Sbjct: 72 AAIDAAMADAVARLGGLDILVAGGALKGGTGNFLDLSDADWDRYVDVNMTGTFLTCRAGA 131 Query: 120 RGLIARGV-----PGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 R ++A G I+ + S S A + Y + KG + MLT+ MA++L H I V Sbjct: 132 RAMVAAGAGKDGRSARIITIGSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGILV 191 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 N + P V + +S+P A+ +L+ + LG+ E V A +FL D S TGST Sbjct: 192 NMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRPGLPEEVATAAVFLAEDGSSFITGST 251 Query: 235 LPVEGGFWA 243 + ++GG A Sbjct: 252 ITIDGGLSA 260 >2ZAT-A nrPDB Length = 260 Score = 101 bits (251), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/248 (31%), Positives = 121/248 (48%), Gaps = 16/248 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 L + LVT + GIG + L GA VV SR Q ++D V G + Sbjct: 12 LENKVALVTASTDGIGLAIARRLAQDGAHVVVSSRKQENVDRTVATLQGEGLSVTGTVCH 71 Query: 61 LGDWEATER----ALGSVGPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRAVI 112 +G E ER A+ G VD+LV+NAAV PF ++ T+E +D+ VN++A + Sbjct: 72 VGKAEDRERLVAMAVNLHGGVDILVSNAAV---NPFFGNIIDATEEVWDKILHVNVKATV 128 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 +++ V + RG G+++ VSS + N Y +K AL LTK +A+EL P I Sbjct: 129 LMTKAVVPEMEKRG-GGSVLIVSSVGAYHPFPNLGPYNVSKTALLGLTKNLAVELAPRNI 187 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 RVN + P ++ T+ Q W D + + M + + + E + FL S+ + TG Sbjct: 188 RVNCLAPGLIKTNFSQVLWMDKARKEYMKESLRIRRLGNPEDCAGIVSFLCSEDASYITG 247 Query: 233 STLPVEGG 240 T+ V GG Sbjct: 248 ETVVVGGG 255 >3F9I-A nrPDB Length = 249 Score = 100 bits (249), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 70/241 (29%), Positives = 118/241 (48%), Gaps = 8/241 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL---VRECPGIEPVCVDL 61 L G+ L+TGA GIG + LH G++V+ + L SL +++ IE VC +L Sbjct: 12 LTGKTSLITGASSGIGSAIARLLHKLGSKVIISGSNEEKLKSLGNALKDNYTIE-VC-NL 69 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 + E + +D+LV NA + + + + FD+ ++NL+A +++ + Sbjct: 70 ANKEECSNLISKTSNLDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFILNREAIKK 129 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 +I + G I+N+SS + YC++K L +TK ++ E+ I VNAV P Sbjct: 130 MIQKRY-GRIINISSIVGIAGNPGQANYCASKAGLIGMTKSLSYEVATRGITVNAVAPGF 188 Query: 182 VMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + + M +A ++ +IPLG + E V A+ FL S+ + TG TL V GG Sbjct: 189 IKSDMTDKLNEKQREA--IVQKIPLGTYGIPEDVAYAVAFLASNNASYITGQTLHVNGGM 246 Query: 242 W 242 Sbjct: 247 L 247 >2NM0-A nrPDB Length = 253 Score = 100 bits (249), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 73/239 (30%), Positives = 114/239 (47%), Gaps = 16/239 (6%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP-GIEPVCVDLGDWEA 66 R VLVTG +GIG +A G +V R+ E P G V D+ D E Sbjct: 22 RSVLVTGGNRGIGLAIARAFADAGDKVAITYRSG--------EPPEGFLAVKCDITDTEQ 73 Query: 67 TERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 E+A + GPV++L+ NA V Q + +++E F E NL +V + R + Sbjct: 74 VEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRVVKRANRAM 133 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 + R G +V +SS + Y ++K L + +A ELG I N V P V Sbjct: 134 L-RAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITFNVVAPGFV 192 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M + +D +A +++++PLG++A E + + FL SD + TG+ +PV+GG Sbjct: 193 DTDMTK-VLTDEQRAN-IVSQVPLGRYARPEEIAATVRFLASDDASYITGAVIPVDGGL 249 >3OSU-A nrPDB Length = 246 Score = 99.8 bits (247), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 74/244 (30%), Positives = 117/244 (47%), Gaps = 12/244 (4%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSLVRE--CPGIEPVCVDLGDW 64 + LVTGA +GIGR L G V V + ++ +++V E G++ + Sbjct: 5 KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVA 64 Query: 65 EATE------RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 +A E + G +D+LVNNA + + + ++ +D + NL+ V Q Sbjct: 65 DADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKA 124 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 ++ R GAI+N+SS + Y +TK + LTK A EL I VNAV Sbjct: 125 TPQML-RQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVA 183 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P +++ M A SD K + ML +IPL +F + + N + FL SD++ TG T+ V Sbjct: 184 PGFIVSDMTDA-LSDELKEQ-MLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVN 241 Query: 239 GGFW 242 GG + Sbjct: 242 GGMY 245 >2HQ1-A nrPDB Length = 247 Score = 99.4 bits (246), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 14/247 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAV-SRTQADLDSLVRE--CPGIEPVCV-- 59 L G+ +VTG+ +G+G+ L GA +V S LD+ E GI V Sbjct: 3 LKGKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLDATAEEFKAAGINVVVAKG 62 Query: 60 DLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ + E E A+ + G +D+LVNNA + L+++++ +D NL++ + Sbjct: 63 DVKNPEDVENMVKTAMDAFGRIDILVNNAGITRDTLMLKMSEKDWDDVLNTNLKSAYLCT 122 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V++ ++ + G I+N++S + Y ++K L TK +A E I N Sbjct: 123 KAVSK-IMLKQKSGKIINITSIAGIIGNAGQANYAASKAGLIGFTKSIAKEFAAKGIYCN 181 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTM-LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 AV P ++ T M P K K M LN IPL +F E V N + FL SD S TG Sbjct: 182 AVAPGIIKTDMTDVL---PDKVKEMYLNNIPLKRFGTPEEVANVVGFLASDDSNYITGQV 238 Query: 235 LPVEGGF 241 + ++GG Sbjct: 239 INIDGGL 245 >5T5Q-A nrPDB Length = 247 Score = 99.4 bits (246), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 122/252 (48%), Gaps = 19/252 (7%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 M+ R +++TGA GIGR + HA+GA +V + LD+ E + Sbjct: 3 MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATI 62 Query: 61 LGDWEATERALGSV-------GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D + + A +V G +D LV +A + +PF E++ + R+ +NL V Sbjct: 63 KADASSADDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDGVFY 122 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + + R L A +IV ++S + R ++ Y +TKGA+ +T+ ++ EL P K R Sbjct: 123 LCK---RALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAMVSMTRALSRELAP-KTR 178 Query: 174 VNAVNPTVV---MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 VN V+P ++ MTS T D +T L R LGK +E+ V I FL S + Sbjct: 179 VNGVSPGIIETPMTSELLKTRMDETMTQTPLKR--LGKPSEIASV---IAFLCSPAASFV 233 Query: 231 TGSTLPVEGGFW 242 TG T+ V GG + Sbjct: 234 TGETIQVNGGIY 245 >6CI9-A nrPDB Length = 259 Score = 99.4 bits (246), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 76/248 (30%), Positives = 108/248 (43%), Gaps = 18/248 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 L GR +VTG KGIGRG + G VV R Q DLD V + G + V D Sbjct: 7 LEGRSAIVTGGSKGIGRGIAETFANAGVDVVITGRNQDDLDRTVADLSGTRGKVTAVRAD 66 Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + D E R + G +D++ NA + ++T + ++ VN + + + Q Sbjct: 67 VTDPEDARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTVYIVQ 126 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + L A G +V S S Y ++K A + A+EL P KI +NA Sbjct: 127 AALQALTASGHGRVVVTSSITGPITGYPGWSHYGASKAAQLGFLRTAAMELAPKKITINA 186 Query: 177 VNPTVVMT----SMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 V P +MT MGQ M + IP G+ V + NA LF +D + TG Sbjct: 187 VLPGNIMTEGLDEMGQ------DYLDQMASAIPAGRLGSVADIGNAALFFATDEAAYVTG 240 Query: 233 STLPVEGG 240 TL V+GG Sbjct: 241 QTLVVDGG 248 >4NBT-A nrPDB Length = 240 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 75/246 (30%), Positives = 118/246 (47%), Gaps = 20/246 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+ ++TG KG+G+ A GA+V+A DL L P +E + +++ D Sbjct: 4 LEGKVAVITGGAKGLGQAIALAYAEEGAKVIA-----GDLGDLTYSHPNVEGMYLNVTDV 58 Query: 65 EATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 E+ SV G +D+LVNNA + ++T+ +D +VNL+ V ++++V Sbjct: 59 TGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNLTRLVGP 118 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALE--LGPHKIRVNAVN 178 + G G+I+N+SS + Y +TK + LT A E L +RVNA+ Sbjct: 119 QMQTNGY-GSIINISSVVGVFGNIGQANYAATKAGVIGLTMTWAKEFALKGANVRVNAIA 177 Query: 179 PTVVMTSMGQAT---WSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 P +MT + + D A TMLNR+ + E + LFL SD + TG T+ Sbjct: 178 PGYIMTDILKTVPQDLLDKFAALTMLNRL-----GQPEEIAKVALFLASDDASYVTGQTI 232 Query: 236 PVEGGF 241 V GG Sbjct: 233 NVNGGM 238 >3WOH-A nrPDB Length = 251 Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 79/250 (31%), Positives = 112/250 (44%), Gaps = 22/250 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPV------ 57 L+G+ LVTG +G+GR L GA V V + DS +E G IE + Sbjct: 9 LSGKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSD---DSSAKETQGEIERLGGTARS 65 Query: 58 --CVDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 C D+ D E R + +V GPVD+LVNNA + + E +D NL+ Sbjct: 66 YRC-DVSDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGA 124 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 + G I R G+I+N+SS + Y S K L LTK +A EL Sbjct: 125 FLFIKACYFGFI-RKRSGSIINISSVSGVFGSAGQANYASAKAGLIGLTKSIAKELAERN 183 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 +R NAV P ++ T M Q D + L+ +P+ +F + V + FL D S T Sbjct: 184 VRCNAVAPGLIATDMTQDLVDDSKR----LDPVPMRRFGRPDEVAGLVAFLAGDESSYIT 239 Query: 232 GSTLPVEGGF 241 G + V+GG Sbjct: 240 GQVVCVDGGM 249 >4CQL-A nrPDB Length = 261 Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/249 (30%), Positives = 117/249 (46%), Gaps = 20/249 (8%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--ECPGIEP---------VCV 59 LVTGAG GIGR L GA V A +A VR PG + Sbjct: 15 LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQA 74 Query: 60 DLGDWEATERALGSVG-----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + A L V P ++V+ A + + L ++++ +D+ VNL+ V Sbjct: 75 DVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLV 134 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 +Q A+ L++ G G+I+N+SS + + Y ++K + LT+ A ELG H IR Sbjct: 135 TQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRC 194 Query: 175 NAVNPTVVMTSMGQATWSDPHK-AKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N+V P + T M Q P K + IP+G + E V + + FL S+ SG TG+ Sbjct: 195 NSVLPGFIATPMTQKV---PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGT 251 Query: 234 TLPVEGGFW 242 ++ V GG + Sbjct: 252 SVEVTGGLF 260 >3EZL-A nrPDB Length = 256 Score = 97.4 bits (241), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 122/251 (48%), Gaps = 18/251 (7%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQA--------DLDSLVRECPGI 54 + ++ R VTG GIG Q LH G RVVA + D +L + Sbjct: 9 MVMSQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYAS 68 Query: 55 EPVCVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 E ++GDW++T++A VG +D+LVNNA + F ++T+E + + NL + Sbjct: 69 EG---NVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTS 125 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + V++ V G++ RG G I+N+SS Q+ + Y + K + T +A E+ Sbjct: 126 LFNVTKQVIDGMVERGW-GRIINISSVNGQKGQFGQTNYSTAKAGIHGFTMSLAQEVATK 184 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 + VN V+P + T M +A P + ++ IP+ + + + + + +L S+ SG + Sbjct: 185 GVTVNTVSPGYIGTDMVKAI--RPDVLEKIVATIPVRRLGSPDEIGSIVAWLASEESGFS 242 Query: 231 TGSTLPVEGGF 241 TG+ + GG Sbjct: 243 TGADFSLNGGL 253 >3EMK-A nrPDB Length = 246 Score = 97.4 bits (241), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 76/245 (31%), Positives = 120/245 (48%), Gaps = 14/245 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV---DL 61 L GR+ LVTGA G+G +ALHA GA V + L L E E + V +L Sbjct: 5 LTGRKALVTGATGGLGEAIARALHAQGAIVGLHGTREEKLKELAAELG--ERIFVFPANL 62 Query: 62 GDWEATERALG-----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 D EA +ALG +G VD+LVNNA + F+ ++ E +D VNL +V +++ Sbjct: 63 SDREAV-KALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFNLTR 121 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + ++ R G I+N++S + YC++K L +K +A E+ + VN Sbjct: 122 ELTHPMMRR-RNGRIINITSIVGVTGNPGQANYCASKAGLIGFSKSLAQEIASRNVTVNC 180 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 + P + ++M ++ K M N IP+ + + A+++L SD + TG TL Sbjct: 181 IAPGFIESAM-TGKLNEKQKDAIMGN-IPMKRMGVGADIAAAVVYLASDEAAYVTGQTLH 238 Query: 237 VEGGF 241 V GG Sbjct: 239 VNGGM 243 >4K6F-A nrPDB Length = 255 Score = 96.7 bits (239), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 74/245 (30%), Positives = 116/245 (47%), Gaps = 11/245 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAV---SRTQAD--LDSLVRECPGIEPVCV 59 + R +VTG G+G L+ G RVV + T AD L + V Sbjct: 9 MTKRIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPV 68 Query: 60 DLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ D ++ E+ + VGPVD+LVNNA + ++ K +D NL +V ++ Sbjct: 69 DVADHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMT 128 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V G++ RG G IVN+SS + + Y + K + TK +ALE+ + VN Sbjct: 129 KPVCDGMVERGW-GRIVNISSVNGSKGSVGQTNYAAAKAGMHGFTKSLALEIARKGVTVN 187 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 V+P + T M A D K +L +IP G+ + E V + +L S+ +G TGS + Sbjct: 188 TVSPGYLATKMVTAIPQDILDTK-ILPQIPAGRLGKPEEVAALVAYLCSEEAGFVTGSNI 246 Query: 236 PVEGG 240 + GG Sbjct: 247 AINGG 251 >1GEG-A nrPDB Length = 256 Score = 95.1 bits (235), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 111/252 (44%), Gaps = 25/252 (9%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEPVCV--DLGD--- 63 LVTGAG+GIG+ L G V A ++ E G V V D+ D Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 64 -WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 + A E+A ++G D++VNNA VA P +T E D+ + +N++ VI Q Sbjct: 66 VFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGIQAAVEAF 125 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 G G I+N SQ +VY S+K A+ LT+ A +L P I VN P +V Sbjct: 126 KKEGHGGKIINACSQAGHVGNPELAVYSSSKFAVRGLTQTAARDLAPLGITVNGYCPGIV 185 Query: 183 MTSMGQATWSD-------------PHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 T M W++ + RI LG+ +E E V + +L S S Sbjct: 186 KTPM----WAEIDRQVSEAAGKPLGYGTAEFAKRITLGRLSEPEDVAACVSYLASPDSDY 241 Query: 230 TTGSTLPVEGGF 241 TG +L ++GG Sbjct: 242 MTGQSLLIDGGM 253 >4KMS-A nrPDB Length = 249 Score = 95.1 bits (235), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 109/235 (46%), Gaps = 8/235 (3%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERA 70 +VTG +GIG+ T L G VVA + D + E GI+ C ++ D+E +A Sbjct: 14 IVTGGTRGIGKATALELKNKGLTVVANFFSNYDAAKEMEEKYGIKTKCWNVADFEECRQA 73 Query: 71 LGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125 + + PV +LVNNA + + ++ + ++ VNL + +S V + + Sbjct: 74 VKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMSSSVMEQMRNQ 133 Query: 126 GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTS 185 G IVN+SS +Q + Y + K + TK +A E I VN + P + T Sbjct: 134 DY-GRIVNISSINAQAGQVGQTNYSAAKAGIIGFTKALARETASKNITVNCIAPGYIATE 192 Query: 186 MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 M A D ++N IP + + E + A+ FL+ + +G TG T+ + GG Sbjct: 193 MVGAVPEDV--LAKIINSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGG 245 >4GKB-A nrPDB Length = 258 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 88/253 (34%), Positives = 129/253 (50%), Gaps = 15/253 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD---LDSLVRECPGIEPV 57 M+L L + V+VTG GIG L A V +R D LD+L + P + Sbjct: 1 MDLNLQDKVVIVTGGASGIGGAISMRLAEERAIPVVFARHAPDGAFLDALAQRQPRATYL 60 Query: 58 CVDLGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 V+L D +A + + + G +D LVNNA V L+ ++AF S E NL Sbjct: 61 PVELQDDAQCRDAVAQTIATFGRLDGLVNNAGVND-GIGLDAGRDAFVASLERNLIHYYA 119 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ L + GAIVN+SS+ + N S YC++KGA LT+ A+ L H +R Sbjct: 120 MAHYCVPHL--KATRGAIVNISSKTAVTGQGNTSGYCASKGAQLALTREWAVALREHGVR 177 Query: 174 VNAVNPTVVMTSMGQ---ATWSDPH-KAKTMLNRIPLG-KFAEVEHVVNAILFLLSDRSG 228 VNAV P VMT + + AT+ DP K + ++PLG +F + + + +FLLS R+ Sbjct: 178 VNAVIPAEVMTPLYRNWIATFEDPEAKLAEIAAKVPLGRRFTTPDEIADTAVFLLSPRAS 237 Query: 229 MTTGSTLPVEGGF 241 TTG L V+GG+ Sbjct: 238 HTTGEWLFVDGGY 250 >3OIC-A nrPDB Length = 258 Score = 92.4 bits (228), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 69/239 (28%), Positives = 128/239 (53%), Gaps = 10/239 (4%) Query: 11 LVTGAGKGIGRGTVQALHATGARVV---AVSRTQADLDSLVRECPGIEPVCV--DLGD-- 63 LVTG+ +G+G+ L G +V A S+ A + E G++ + V ++G Sbjct: 8 LVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANVGQPA 67 Query: 64 --WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 E ++ + G +D+ VNNAA +L+P +E+ + +D + +N +A++ +Q A+ Sbjct: 68 KIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQEAAK- 126 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 L+ + G IV++SS S R + N++ +K AL+ LT+ +A+EL P +I VNAV+ Sbjct: 127 LMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNAVSGGA 186 Query: 182 VMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + T + + + P G+ E++ +V+ + FL+S ++ M G T+ V+GG Sbjct: 187 IDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTIIVDGG 245 >2EW8-A nrPDB Length = 249 Score = 90.9 bits (224), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 72/244 (29%), Positives = 118/244 (48%), Gaps = 11/244 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARV-----VAVSRTQADLDSLVRECPGIEPVCV 59 L + ++TG GIGR + GA + V +A + +L R ++ Sbjct: 5 LKDKLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRNLGRRVLTVKCDVS 64 Query: 60 DLGDWEAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 GD EA ++ + + G D+LVNNA + L PF E+T E + ++FE+N+ + +++ Sbjct: 65 QPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLMAKAF 124 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G+ G G I+N++S + ++ Y STK A T+ +A +LG I VNA+ Sbjct: 125 VPGMKRNGW-GRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGKDGITVNAIA 183 Query: 179 PTVVMTSMGQATWSDP--HKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 P++V T+ +A+ ML IP + + A FL SD + TG TL Sbjct: 184 PSLVRTATTEASALSAMFDVLPNMLQAIP--RLQVPLDLTGAAAFLASDDASFITGQTLA 241 Query: 237 VEGG 240 V+GG Sbjct: 242 VDGG 245 >3V2G-A nrPDB Length = 271 Score = 90.9 bits (224), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 16/248 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVV-----AVSRTQADLDSLVRECPGIEPV 57 + LAG+ VTG +GIG + L GA V A R QA + + + + Sbjct: 27 ISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRAVAI 86 Query: 58 CVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D D EA E+A+ ++G +D+LVN+A + P E T FD VN RA Sbjct: 87 RADNRDAEAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFDEVMAVNFRAPFV 146 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAV-TNHSVYCSTKGALDMLTKVMALELGPHKI 172 + +R L G G I+ + S ++ S+Y ++K AL LTK +A +LGP I Sbjct: 147 AIRSASRHL---GDGGRIITIGSNLAELVPWPGISLYSASKAALAGLTKGLARDLGPRGI 203 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 VN V+P T M A D A+ RI G + E + + + +L + TG Sbjct: 204 TVNIVHPGSTDTDMNPA---DGDHAEAQRERIATGSYGEPQDIAGLVAWLAGPQGKFVTG 260 Query: 233 STLPVEGG 240 ++L ++GG Sbjct: 261 ASLTIDGG 268 >4BO1-A nrPDB Length = 269 Score = 90.9 bits (224), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 71/249 (28%), Positives = 121/249 (48%), Gaps = 13/249 (5%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVV--AVSRTQADLDSLVRECPGIEP--VC 58 + L G+ LVTGA +GIG+ L GA V+ A S + A+ + + G+E + Sbjct: 23 MSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLV 82 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +D+ E+ L + G ++VNNA + + + + + NL ++ ++ Sbjct: 83 LDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYRL 142 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ V RG+ + G I+N+ S + Y + K L+ T+ +A E+G I V Sbjct: 143 SKAVLRGM-TKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITV 201 Query: 175 NAVNPTVVMTSMGQATWSDPH-KAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 NAV P + T M T P + + +L +IPLG+ + E + + FL SD + TG+ Sbjct: 202 NAVAPGFIDTDM---TRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGA 258 Query: 234 TLPVEGGFW 242 T+PV GG + Sbjct: 259 TVPVNGGMY 267 >2FWM-X nrPDB Length = 250 Score = 90.9 bits (224), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/248 (29%), Positives = 111/248 (44%), Gaps = 19/248 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 +G+ V VTGAGKGIG T A GA+V + + +E +D+ D Sbjct: 5 FSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQ------AFTQEQYPFATEVMDVADA 58 Query: 65 ----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 + +R L +D LVN A + + +++KE + ++F VN+ + Q Sbjct: 59 AQVAQVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMN 118 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 R GAIV V+S + S Y ++K AL L + LEL +R N V+P Sbjct: 119 -QFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPG 177 Query: 181 VVMTSMGQATW-SDPHKAKTMLN-------RIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 T M + W SD + + + IPLGK A + + N ILFL SD + T Sbjct: 178 STDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITL 237 Query: 233 STLPVEGG 240 + V+GG Sbjct: 238 QDIVVDGG 245 >1AHH-A nrPDB Length = 255 Score = 90.5 bits (223), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/248 (30%), Positives = 123/248 (49%), Gaps = 13/248 (5%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLV----RECPGIEPV 57 L L G+ ++TGAG GIG+ GA VV VS AD + V ++ G Sbjct: 6 NLRLDGKCAIITGAGAGIGKEIAITFATAGASVV-VSDINADAANHVVDEIQQLGGQAFA 64 Query: 58 C-VDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 C D+ + + A+ +G VD+LVNNA +PF ++ F R++E+N+ + Sbjct: 65 CRCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPF-DMPMADFRRAYELNVFSFF 123 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 +SQ+VA + G G I+ ++S ++ N + Y S+K A L + MA +LG I Sbjct: 124 HLSQLVAPEMEKNG-GGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNI 182 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 RVN + P ++T ++ + P + ML P+ + + + + NA LFL S + +G Sbjct: 183 RVNGIAPGAILTDALKSVIT-PEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSG 241 Query: 233 STLPVEGG 240 L V GG Sbjct: 242 QILTVSGG 249 >3LYL-A nrPDB Length = 247 Score = 90.5 bits (223), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 115/240 (47%), Gaps = 11/240 (4%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD----SLVRECPGIEPVCVDLGDWEA 66 LVTGA +GIG AL + GA VV + +QA + S+ + + +++ D E+ Sbjct: 9 LVTGASRGIGFEVAHALASKGATVVGTATSQASAEKFENSMKEKGFKARGLVLNISDIES 68 Query: 67 TERALGSVGP----VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 + + +D+LVNNA + + ++++ + NL ++ ++S+ RG+ Sbjct: 69 IQNFFAEIKAENLAIDILVNNAGITRDNLMMRMSEDEWQSVINTNLSSIFRMSKECVRGM 128 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 + + G I+++ S + YC+ K + +K +A E+ I VN V P + Sbjct: 129 MKK-RWGRIISIGSVVGSAGNPGQTNYCAAKAGVIGFSKSLAYEVASRNITVNVVAPGFI 187 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 T M +D K+ + +IP G+ E + + A+ FL S+ + TG TL V GG + Sbjct: 188 ATDMTD-KLTDEQKS-FIATKIPSGQIGEPKDIAAAVAFLASEEAKYITGQTLHVNGGMY 245 >3VZS-A nrPDB Length = 257 Score = 90.1 bits (222), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 71/245 (28%), Positives = 116/245 (47%), Gaps = 16/245 (6%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLVRECPGIEPVCVD-- 60 R VTG GIG Q L G RVVA R + L+ ++ G + + + Sbjct: 15 RIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQ--QKALGFDFIASEGN 72 Query: 61 LGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + DW++T+ A VG VD+L+NNA + F ++T+ +D + NL ++ V++ Sbjct: 73 VADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTK 132 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 V G+ RG G IVN+SS Q+ + Y + K L T +A E+ + VN Sbjct: 133 QVIDGMADRGW-GRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNT 191 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 V+P + T M +A D ++ IP+ + E + + +L S+ SG +TG+ Sbjct: 192 VSPGYIATDMVKAIRQDV--LDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFS 249 Query: 237 VEGGF 241 + GG Sbjct: 250 LNGGL 254 >1UZM-A nrPDB Length = 247 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 112/237 (47%), Gaps = 14/237 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG Q L A G +V R L G+E VD+ D +A Sbjct: 16 RSVLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAPKGLF----GVE---VDVTDSDAV 68 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA +V GPV++LV+NA ++ + +T+E F++ NL +V+Q +R + Sbjct: 69 DRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSM- 127 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G ++ + S + N + Y ++K + + + +A EL + N V P + Sbjct: 128 QRNKFGRMIFIGSVSGLWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAPGYID 187 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 T M +A D + L IP + V + FL S+ + +G+ +PV+GG Sbjct: 188 TDMTRAL--DERIQQGALQFIPAKRVGTPAEVAGVVSFLASEDASYISGAVIPVDGG 242 >1GEE-A nrPDB Length = 261 Score = 88.6 bits (218), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 116/247 (46%), Gaps = 11/247 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-LDSLVRECP--GIEPVCVDL 61 L G+ V++TG+ G+G+ A+VV R++ D +S++ E G E + V Sbjct: 5 LEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAIAVK- 63 Query: 62 GD-------WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 GD + A+ G +D+++NNA + E++ +++ + NL Sbjct: 64 GDVTVESDVINLVQSAIKEFGKLDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGAFLG 123 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ + + + G ++N+SS + Y ++KG + ++T+ +ALE P IRV Sbjct: 124 SREAIKYFVENDIKGTVINMSSVHEKIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRV 183 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 N + P + T + ++DP + + + IP+G E E + +L S + TG T Sbjct: 184 NNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEEIAAVAAWLASSEASYVTGIT 243 Query: 235 LPVEGGF 241 L +GG Sbjct: 244 LFADGGM 250 >3OEC-A nrPDB Length = 317 Score = 88.6 bits (218), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 118/270 (43%), Gaps = 35/270 (12%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS--RTQADLD-------------SLV- 48 L G+ +TGA +G GR L GA +VA+ R Q +LD LV Sbjct: 44 LQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLVE 103 Query: 49 ---RECPGIEPVCVDLGDWEAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSF 104 R + DL +A + AL G +D+LV+N ++ + +T + + Sbjct: 104 EQGRRIIARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDIL 163 Query: 105 EVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164 + NL + V +I RG G+++ VSS R S Y ++K + L +A Sbjct: 164 QTNLIGAWHACRAVLPSMIERGQGGSVIFVSSTVGLRGAPGQSHYAASKHGVQGLMLSLA 223 Query: 165 LELGPHKIRVNAVNPTVVMTSMG--------------QATWSDPHKAKTMLNRIPLGKFA 210 E+G H IRVN+VNP V T M T D + + L +P+ + Sbjct: 224 NEVGRHNIRVNSVNPGAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPI-PWV 282 Query: 211 EVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 E E V NA+ +L SD + G+ +PV+GG Sbjct: 283 EPEDVSNAVAWLASDEARYIHGAAIPVDGG 312 >3A28-C nrPDB Length = 258 Score = 88.2 bits (217), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 79/254 (31%), Positives = 115/254 (45%), Gaps = 29/254 (11%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP-------VCVDLGD 63 +VTG +GIGRG + L A G + Q + + IE V +D+ D Sbjct: 6 MVTGGAQGIGRGISEKLAADGFDIAVADLPQQE-EQAAETIKLIEAADQKAVFVGLDVTD 64 Query: 64 W----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 A + A +G D+LVNNA +A ++P LEVT+E + + VN+ +V Q + Sbjct: 65 KANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAAS 124 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 R GV G I+N +S + + S Y +TK A+ LT+ A EL P VNA P Sbjct: 125 RKFDELGVKGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGHTVNAYAP 184 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGK-FAEV------------EHVVNAILFLLSDR 226 +V T M W + +N P+G+ F E E V + FL S+ Sbjct: 185 GIVGTGM----WEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASEN 240 Query: 227 SGMTTGSTLPVEGG 240 S TG + V+GG Sbjct: 241 SNYVTGQVMLVDGG 254 >5OVJ-A nrPDB Length = 256 Score = 87.0 bits (214), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 105/238 (44%), Gaps = 14/238 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG + L A G +V R D L V D+ D A Sbjct: 25 RSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLF-------GVQCDVTDSAAV 77 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA V GPV++LV NA ++ + +T+E F+ NL + +Q +R + Sbjct: 78 DRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASR-TM 136 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G I+ + S + N + Y + K L + + ++ EL + N V P + Sbjct: 137 QRKRFGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSISRELAKAGVTANVVAPGYID 196 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M +A D L+ IP + E V A+ FL S+ + G+ +PV+GG Sbjct: 197 TEMTRAL--DERIQAGALDFIPAKRVGTAEEVAGAVSFLASEDASYIAGAVIPVDGGM 252 >5OVL-A nrPDB Length = 300 Score = 86.7 bits (213), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 105/237 (44%), Gaps = 14/237 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG + L A G +V R D L V D+ D A Sbjct: 69 RSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLF-------GVQCDVTDSAAV 121 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA V GPV++LV NA ++ + +T+E F+ NL + +Q +R + Sbjct: 122 DRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASR-TM 180 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G I+ + S + N + Y + K L + + ++ EL + N V P + Sbjct: 181 QRKRFGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSISRELAKAGVTANVVAPGYID 240 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 T M +A D L+ IP + E V A+ FL S+ + G+ +PV+GG Sbjct: 241 TEMTRAL--DERIQAGALDFIPAKRVGTAEEVAGAVSFLASEDASYIAGAVIPVDGG 295 >2CFC-A nrPDB Length = 250 Score = 86.7 bits (213), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 74/248 (29%), Positives = 112/248 (45%), Gaps = 13/248 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--------ECPGIEPVCV 59 R +VTGA G G A G RV A+ + L+ R + + Sbjct: 3 RVAIVTGASSGNGLAIATRFLARGDRVAALDLSAETLEETARTHWHAYADKVLRVRADVA 62 Query: 60 DLGDWEATERA-LGSVGPVDLLVNNAAVALLQP--FLEVTK-EAFDRSFEVNLRAVIQVS 115 D GD A A + G +D+LVNNA + L T E FD+ VN+R + Sbjct: 63 DEGDVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLHTTPVEQFDKVMAVNVRGIFLGC 122 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V ++ +G G IVN++S S A S Y ++KGA+ LTK +A++ IR N Sbjct: 123 RAVLPHMLLQGA-GVIVNIASVASLVAFPGRSAYTTSKGAVLQLTKSVAVDYAGSGIRCN 181 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 AV P ++ T M Q P +L RIP + V +A++FL + + G+ L Sbjct: 182 AVCPGMIETPMTQWRLDQPELRDQVLARIPQKEIGTAAQVADAVMFLAGEDATYVNGAAL 241 Query: 236 PVEGGFWA 243 ++G + A Sbjct: 242 VMDGAYTA 249 >2Q2Q-A nrPDB Length = 255 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/256 (30%), Positives = 116/256 (45%), Gaps = 20/256 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV--AVSRTQADLDSLVRECPGIEPVC--VD 60 L G+ LVTG+ GIG G Q L GA +V L + R G++ V D Sbjct: 2 LKGKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPAPALAEIARH--GVKAVHHPAD 59 Query: 61 LGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 L D E G VD+LVNNA + + P + E++D+ +NL AV ++ Sbjct: 60 LSDVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHGTR 119 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + G+ AR G I+N++S T + Y + K + LTKV+ LE + NA Sbjct: 120 LALPGMRARNW-GRIINIASVHGLVGSTGKAAYVAAKHGVVGLTKVVGLETATSNVTCNA 178 Query: 177 VNPTVVMTSMGQ-------ATWSDPHKAKTML--NRIPLGKFAEVEHVVNAILFLLSDRS 227 + P V+T + Q A DP +A+ L + P F EH+ +LFL S+ Sbjct: 179 ICPGWVLTPLVQKQIDDRAANGGDPLQAQHDLLAEKQPSLAFVTPEHLGELVLFLCSEAG 238 Query: 228 GMTTGSTLPVEGGFWA 243 G+ V+GG+ A Sbjct: 239 SQVRGAAWNVDGGWLA 254 >1DOH-A nrPDB Length = 283 Score = 85.9 bits (211), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 121/261 (46%), Gaps = 26/261 (9%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV---AVSRTQADLDSLVRECPGIEPVCV-- 59 L G+ LVTGAG+GIGR L G +V+ A S A+ + G + CV Sbjct: 27 LEGKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVKA 86 Query: 60 DLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 ++G E E A+ G +D++ +N+ V +VT E FDR F +N R V+ Sbjct: 87 NVGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVA 146 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQ-RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 + + L + G ++ + S Q +AV H+VY +KGA++ + MA+++ KI V Sbjct: 147 REAYKHL---EIGGRLILMGSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKITV 203 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVE-----------HVVNAILFLL 223 N V P + T M A + L+ + ++A V+ + + FL Sbjct: 204 NVVAPGGIKTDMYHAVCREYIPNGENLSNEEVDEYAAVQWSPLRRVGLPIDIARVVCFLA 263 Query: 224 SDRSGMTTGSTLPVEGGFWAC 244 S+ G TG + ++GG AC Sbjct: 264 SNDGGWVTGKVIGIDGG--AC 282 >5CDY-A nrPDB Length = 244 Score = 85.9 bits (211), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 116/245 (47%), Gaps = 16/245 (6%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS----LVRECPG-----IEPV 57 G+ LVTGA +GIGR + L GA V+ + ++ ++ L G ++P Sbjct: 5 GKIALVTGASRGIGRAIAELLVERGACVIGTATSEKGAEAISAYLGENGKGLMLNVVDPT 64 Query: 58 CVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 +D AT RA G VD+LVNNA + + + + + + NL +V ++S+ Sbjct: 65 SIDT--VLATIRA--EFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRLSKA 120 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 V R ++ + G I+ + S Y + K + +K +A E+ I VN V Sbjct: 121 VMRAMMKKRF-GRIITIGSVVGTMGNAGQVNYAAAKAGVIGFSKSLAREVASRGITVNVV 179 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + T M + T +D +A +L ++P + + + + +A+ FL SD + +G TL V Sbjct: 180 APGFIETDMTR-TLTDDQRAG-ILAQVPANRLGDAKEIASAVAFLASDEASYISGETLHV 237 Query: 238 EGGFW 242 GG + Sbjct: 238 NGGMY 242 >3T7C-A nrPDB Length = 299 Score = 85.9 bits (211), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 80/269 (29%), Positives = 122/269 (45%), Gaps = 36/269 (13%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLVRECPG- 53 G+ +TGA +G GR L GA ++A+ T DL VR+ Sbjct: 28 GKVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDGVKLPMSTPDDLAETVRQVEAL 87 Query: 54 ---IEPVCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLE-VTKEAFDRSFE 105 I VD+ D++A + A+ +G +D+++ NAA+A L + + + + Sbjct: 88 GRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKTWRDMID 147 Query: 106 VNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMAL 165 VNL +++ ++A G+IV SS R N Y ++K L L + MAL Sbjct: 148 VNLNGAWITARVAIPHIMAGKRGGSIVFTSSIGGLRGAENIGNYIASKHGLHGLMRTMAL 207 Query: 166 ELGPHKIRVNAVNPTVVMTSM--------------GQATWSDPHKAKTMLNRIPLGKFAE 211 ELGP IRVN V P+ V T M T D A ++ +P+ + E Sbjct: 208 ELGPRNIRVNIVCPSSVATPMLLNEPTYRMFRPDLENPTVEDFQVASRQMHVLPI-PYVE 266 Query: 212 VEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + NAILFL+SD + TG +LPV+GG Sbjct: 267 PADISNAILFLVSDDARYITGVSLPVDGG 295 >2PH3-A nrPDB Length = 245 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/246 (29%), Positives = 114/246 (46%), Gaps = 17/246 (6%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE-------CPGIEPVCVD 60 R+ L+TGA +GIGR L G +A+ Q + P + + + Sbjct: 2 RKALITGASRGIGRAIALRLAEDGF-ALAIHYGQNREKAEEVAEEARRRGSPLVAVLGAN 60 Query: 61 LGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 L + EA +A +G +D LVNNA + + + E ++ E NL AV + ++ Sbjct: 61 LLEAEAATALVHQAAEVLGGLDTLVNNAGITRDTLLVRMKDEDWEAVLEANLSAVFRTTR 120 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + L+ + G IVN++S + Y ++K L T+ +A E I VNA Sbjct: 121 EAVK-LMMKARFGRIVNITSVVGILGNPGQANYVASKAGLIGFTRAVAKEYAQRGITVNA 179 Query: 177 VNPTVVMTSMGQATWSDPHKAK-TMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 V P + T M T P + K L +IP G+F E V A+ FL+S+++G TG TL Sbjct: 180 VAPGFIETEM---TERLPQEVKEAYLKQIPAGRFGRPEEVAEAVAFLVSEKAGYITGQTL 236 Query: 236 PVEGGF 241 V+GG Sbjct: 237 CVDGGL 242 >2HSD-A nrPDB Length = 253 Score = 85.1 bits (209), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/244 (31%), Positives = 118/244 (48%), Gaps = 12/244 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-----PVCV 59 L+G+ V++TG +G+G + A GARVV + + RE V + Sbjct: 3 LSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTI 62 Query: 60 DLGDWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTK-EAFDRSFEVNLRAVIQVSQI 117 + DW+ A G VD LVNNA ++ FLE E F + E+NL V + Sbjct: 63 EE-DWQRVVAYAREEFGSVDGLVNNAGISTGM-FLETESVERFRKVVEINLTGVFIGMKT 120 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 V + G G+IVN+SS + S Y ++K + L+K+ A+ELG +IRVN+V Sbjct: 121 VIPAMKDAG-GGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSV 179 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 +P + T M T + + P+G+ E + A++ LLSD S TG+ L V Sbjct: 180 HPGMTYTPMTAET--GIRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAV 237 Query: 238 EGGF 241 +GG+ Sbjct: 238 DGGW 241 >3RWB-A nrPDB Length = 247 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 16/247 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP--VCVDLG 62 LAG+ LVTGA +GIG+ L A GA V+ VS A+ G + + D+ Sbjct: 4 LAGKTALVTGAAQGIGKAIAARLAADGATVI-VSDINAEGAKAAAASIGKKARAIAADIS 62 Query: 63 DWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D + + + G +D+LVNNA++ + +V + + + +VNL V++ Sbjct: 63 DPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRAG 122 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 + A G G +++++S N + Y + KG + T+ +A ELG + I NAV Sbjct: 123 TDQMRAAGKAGRVISIASNTFFAGTPNMAAYVAAKGGVIGFTRALATELGKYNITANAVT 182 Query: 179 PTVVMTSMGQATWSDPHKAK----TMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 P ++ + +A+ PH ML + GK + EH+ + + FL SD + TG T Sbjct: 183 PGLIESDGVKAS---PHNEAFGFVEMLQAMK-GK-GQPEHIADVVSFLASDDARWITGQT 237 Query: 235 LPVEGGF 241 L V+ G Sbjct: 238 LNVDAGM 244 >5EJ2-A nrPDB Length = 308 Score = 84.7 bits (208), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 126/271 (46%), Gaps = 36/271 (13%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLD---SLVR 49 +AG+ ++GA +G GR L GA ++A+ T DL LV+ Sbjct: 35 VAGKVAFISGAARGQGRSHAVRLAQEGADIIAIDICGPIENLAYPHSTPEDLAETADLVK 94 Query: 50 ECPG-IEPVCVDLGDWEATERALGS----VGPVDLLVNNAAVALL-QPFLEVTKEAFDRS 103 + I VD+ D+EA + A+ S +G +D++V NA V + ++ + Sbjct: 95 DLDRRIVTAQVDVRDFEALKSAVDSGVEQLGRLDIIVANAGVGTDGRKLHKIRDNVWQDM 154 Query: 104 FEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVM 163 ++NL V + +++ G G+IV SS ++A N Y + K + L + Sbjct: 155 IDINLTGVWHTVKAGVPHVLSGGRGGSIVLTSSVGGRKAYPNTGHYIAAKHGVIGLMRAF 214 Query: 164 ALELGPHKIRVNAVNPTVVMTS--MGQATW------------SDPHKAKTMLNRIPLGKF 209 A+ELGPH IRVNAV PT V T+ M T+ D M++ +P+ + Sbjct: 215 AVELGPHMIRVNAVLPTQVSTTMVMNDQTFRLFRPDLENPGPDDFAPISQMMHTLPV-PW 273 Query: 210 AEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + NA+LFL SD S TG +LPV+ G Sbjct: 274 VDASDISNAVLFLASDESRYVTGVSLPVDAG 304 >3WYE-A nrPDB Length = 256 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 78/251 (31%), Positives = 114/251 (45%), Gaps = 25/251 (9%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEPVCV--DLGD--- 63 LVTGAG+GIG+ L G V A ++ E G V V D+ D Sbjct: 6 LVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVSDRDQ 65 Query: 64 -WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 + A E+A ++G D++VNNA +A ++P LEVT+E + + VN+ +V Q Sbjct: 66 VFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAAVEAF 125 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 G G I+N +S + + S Y +TK A+ LT+ A +L P I VN P +V Sbjct: 126 KKEGHGGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQTAARDLAPLGITVNGYCPGIV 185 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGK-FAEV------------EHVVNAILFLLSDRSGM 229 T M W + +N P+G+ F E E V + FL S S Sbjct: 186 GTGM----WEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASPDSDY 241 Query: 230 TTGSTLPVEGG 240 TG +L ++GG Sbjct: 242 MTGQSLLIDGG 252 >1H5Q-A nrPDB Length = 265 Score = 84.3 bits (207), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 118/255 (46%), Gaps = 24/255 (9%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE------PVC 58 + ++VTG +GIG +A+ A GA V + R+ AD V E G E Sbjct: 12 FVNKTIIVTGGNRGIGLAFTRAVAAAGANVAVIYRSAADAVE-VTEKVGKEFGVKTKAYQ 70 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + + + + + GP+ L+ NA V++++P E+T E F ++VN+ V Sbjct: 71 CDVSNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVFNT 130 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHS---------VYCSTKGALDMLTKVMAL 165 + VA+ + + G+IV SS SQ + N S Y S+K A L K +A Sbjct: 131 CRAVAKLWLQKQQKGSIVVTSSMSSQ--IINQSSLNGSLTQVFYNSSKAACSNLVKGLAA 188 Query: 166 ELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 E IRVNA++P V T Q D + IPL +FA+ E + + LLSD Sbjct: 189 EWASAGIRVNALSPGYVNTD--QTAHMDKKIRDHQASNIPLNRFAQPEEMTGQAILLLSD 246 Query: 226 RSGMTTGSTLPVEGG 240 + TG ++GG Sbjct: 247 HATYMTGGEYFIDGG 261 >4FC7-A nrPDB Length = 277 Score = 84.0 bits (206), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 11/242 (4%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-----PVCVDL---- 61 +TG G GIG + G V SR+ + + R+ G P+ +D+ Sbjct: 31 FITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPP 90 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 A ++AL G +D+L+N AA L P ++ AF +++ VS+++ Sbjct: 91 AVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEK 150 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 R G IVN+++ R S K A+D +T+ +A+E GP IRVN++ P Sbjct: 151 FF-RDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGP 209 Query: 182 VMTSMGQATWSDPHKA-KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + G P + T + PL + + +++L+L S + TG+ L +GG Sbjct: 210 ISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGG 269 Query: 241 FW 242 W Sbjct: 270 AW 271 >3AUT-A nrPDB Length = 269 Score = 84.0 bits (206), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 113/246 (45%), Gaps = 11/246 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV--AVSRTQADLDSLVR-ECPGIEPVCVDL 61 L + V++TG G+GR A+VV + + LD+ E G + + V Sbjct: 13 LKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAIIVQ- 71 Query: 62 GDWEATER-------ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 GD E A+ G +D+++NNA V P E++ + +++ + NL Sbjct: 72 GDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTGAFLG 131 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ + + + G ++N+SS Y ++KG + ++T+ +ALE P IRV Sbjct: 132 SREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRV 191 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 N + P + T + ++DP + + + IP+G + E V FL S ++ TG T Sbjct: 192 NNIGPGAMNTPINAEKFADPVQRADVESMIPMGYIGKPEEVAAVAAFLASSQASYVTGIT 251 Query: 235 LPVEGG 240 L +GG Sbjct: 252 LFADGG 257 >5B1Y-A nrPDB Length = 270 Score = 84.0 bits (206), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 116/242 (47%), Gaps = 13/242 (5%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE------CPGIEPVCVDLGDW 64 LVTG +GIGR TV G VV +++ADL E P V VD+GD Sbjct: 27 LVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLGSPEAYTVRVDVGDP 86 Query: 65 EATERALGSVGPV----DLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 ++ VG + ++LVN A V L E + ++ + VNL V V++++ Sbjct: 87 DSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVYLVTKLLLP 146 Query: 121 GLIARGVPGAIVNVSSQCSQRA-VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 L+ + +IVNV+S + V Y ++K + LTK +A++L + IRVNAV P Sbjct: 147 -LLRKAKWASIVNVASIAGETGNVVAGVAYSASKAGVIGLTKRLAVQLAGYGIRVNAVAP 205 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS-DRSGMTTGSTLPVE 238 + V T M ++ P K + + + PL + E V AILFL RS TG L + Sbjct: 206 SFVETDMTRSFLDTPEKRERIASLHPLKIILKPEDVAEAILFLADPRRSRGITGHVLSIN 265 Query: 239 GG 240 G Sbjct: 266 AG 267 >1NFF-A nrPDB Length = 260 Score = 83.6 bits (205), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 74/241 (30%), Positives = 116/241 (48%), Gaps = 13/241 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECPGIEPVCVDL-- 61 L G+ LV+G +G+G V+A+ A GA+VV + V +D+ Sbjct: 5 LTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHLDVTQ 64 Query: 62 -GDWEAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 W+A + A+ + G + +LVNNA + + + + R +VNL V + V Sbjct: 65 PAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVV 124 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 + + G G+I+N+SS Y +TK A+ LTK ALELGP IRVN+++P Sbjct: 125 KPMKEAG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVNSIHP 183 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 +V T M D + + LG+ AE V N +++L SD S +TG+ V+G Sbjct: 184 GLVKTPMTDWVPED-------IFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDG 236 Query: 240 G 240 G Sbjct: 237 G 237 >3GRP-A nrPDB Length = 266 Score = 82.8 bits (203), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 114/243 (46%), Gaps = 10/243 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-LDSLVREC-PGIEPVCVDLG 62 L GR+ LVTGA GIG + HA GA +V + T+ D L + + + +L Sbjct: 25 LTGRKALVTGATGGIGEAIARCFHAQGA-IVGLHGTREDKLKEIAADLGKDVFVFSANLS 83 Query: 63 DWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D ++ E A + +D+LVNNA + F+ + + +D VNL A +++ + Sbjct: 84 DRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAASTLTREL 143 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 ++ R G I+N++S + YC+ K L +K +A E+ I VN + Sbjct: 144 IHSMMRRRY-GRIINITSIVGVVGNPGQTNYCAAKAGLIGFSKALAQEIASRNITVNCIA 202 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P + ++M + + + ++ IP+ + E + A ++L SD + TG TL + Sbjct: 203 PGFIKSAMTDKL--NEKQKEAIMAMIPMKRMGIGEEIAFATVYLASDEAAYLTGQTLHIN 260 Query: 239 GGF 241 GG Sbjct: 261 GGM 263 >4NBV-A nrPDB Length = 246 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/245 (30%), Positives = 107/245 (43%), Gaps = 13/245 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVD 60 L GR ++TGA GIG T Q GA VV +R + L + VD Sbjct: 3 LQGRVAIITGAAAGIGFATAQRFAEDGAIVVLCDVQEARVREAAARLAATGATVSAYRVD 62 Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + + + + +V VD+LVNNA + ++T+ FD +VNL+ V +Q Sbjct: 63 VTRRDEVDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNCAQ 122 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 VA GL+ G I+N SS + Y ++K + TK A ELGP +RVNA Sbjct: 123 AVA-GLMTEQGKGVILNASSVVGLYGNFGQTNYAASKFGVIGFTKTWARELGPKGVRVNA 181 Query: 177 VNPTVVMTSMGQATWSDPHKA-KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 V P V T + Q P K M + L + AE + + FL SD + G + Sbjct: 182 VCPGFVNTEILQTV---PDKVLDGMTSSCWLRRLAEPAEIASIYAFLASDDASYVNGVAI 238 Query: 236 PVEGG 240 GG Sbjct: 239 EASGG 243 >4CQM-B nrPDB Length = 244 Score = 82.0 bits (201), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 21/240 (8%) Query: 12 VTGAGKGIGRGTVQALHATGARVVAVSRT-------QADL--DSLVRECPGIEPVCVDLG 62 V G +GIGR Q + G R+ ++R DL D L C + V Sbjct: 14 VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQ-N 72 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 +E E+ LG V + LVN A + + E NL + + R + Sbjct: 73 TFEELEKHLGRV---NFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 129 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 I + G+IVNV S + + SVY ++KG L ++ +A E+ KIRVN V P V Sbjct: 130 IQQ-QGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 188 Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 T M + K + + IPLG+F E V +A++FLL S TG L V+GG Sbjct: 189 HTDM-----TKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE--SPYITGHVLVVDGGLQ 241 >3V8B-A nrPDB Length = 283 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 21/249 (8%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV----DLGDWEA 66 L+TGAG GIGR T AL A G V A+ RT+ +++ + E G + D+ D Sbjct: 32 LITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVGAGGQAIALEADVSDELQ 91 Query: 67 TERALGSV----GPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 A+ + G +D++V NA + + P ++ +D + VNLR + Sbjct: 92 MRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFEWDETIAVNLRGTFLTLHLTVPY 151 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKV--MALELGPHKIRVNAVNP 179 L RG GAIV VSS R T T + V +ALELG H IRVNAV P Sbjct: 152 LKQRG-GGAIVVVSSINGTRTFTTPGATAYTATKAAQVAIVQQLALELGKHHIRVNAVCP 210 Query: 180 TVVMTSMGQATWSDPHKAKTML------NRIPL--GKFAEVEHVVNAILFLLSDRSGMTT 231 + T++ T H+ +T + ++P+ G+ E V I FL+S+R+ T Sbjct: 211 GAIETNISDNT-KLRHEEETAIPVEWPKGQVPITDGQPGRSEDVAELIRFLVSERARHVT 269 Query: 232 GSTLPVEGG 240 GS + ++GG Sbjct: 270 GSPVWIDGG 278 >3WTC-A nrPDB Length = 262 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/260 (25%), Positives = 111/260 (42%), Gaps = 25/260 (9%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE----PVC 58 + L+G+ VTGA +GIG+ L GA V+ + Q L +E + + Sbjct: 4 MSLSGKIAAVTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEVEALGRRAVALT 63 Query: 59 VDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + + L ++G +D++VNNA + ++P L++ ++ F +N++ V+ Sbjct: 64 ADISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLWG 123 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 Q A +G G I+N S Y +TK A+ LT+ A EL I V Sbjct: 124 MQAAATLFKEKGTKGKIINACSIAGHEGYPLLGAYSATKFAVRALTQSAAKELASSGITV 183 Query: 175 NAVNPTVVMTSMGQATWSDPHK-------------AKTMLNRIPLGKFAEVEHVVNAILF 221 N+ P +V T M W K K + I LG+ + V + + Sbjct: 184 NSYCPGIVGTDM----WVTIDKRMAEITGTEIGATYKKYVEGIALGRVETADDVAGFVAY 239 Query: 222 LLSDRSGMTTGSTLPVEGGF 241 L S + TG ++ ++GG Sbjct: 240 LSSSDADYMTGQSVLIDGGL 259 >5YSS-A nrPDB Length = 256 Score = 81.3 bits (199), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 73/254 (28%), Positives = 115/254 (45%), Gaps = 20/254 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV--AVSRTQADLDSLVR--ECPGIEPVCVD 60 L G+ LVTG+ GIG G Q L GA ++ A D++ + + PG D Sbjct: 3 LTGKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDVDAAKDAVAQYGKTPGYH--GAD 60 Query: 61 LGDW----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 L D + A G VD+L+NNA + + P + ++ +NL +V ++ Sbjct: 61 LSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVDKWNAIIAINLSSVFHTTR 120 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + G+ AR G I+N++S A S Y + K + LTK +ALE +I NA Sbjct: 121 LALPGMRARNW-GRIINIASVHGLVASKEKSAYVAAKHGVVGLTKTIALETAQTEITCNA 179 Query: 177 VNPTVVMTSMGQ-------ATWSDPHKAKTML--NRIPLGKFAEVEHVVNAILFLLSDRS 227 + P V+T + Q A ++P A+ L + P +F E + N LFL SD + Sbjct: 180 LCPGWVLTPLVQQQIDKRIAEGAEPEAARDALLAEKQPSREFVTPEQLGNLALFLCSDGA 239 Query: 228 GMTTGSTLPVEGGF 241 G ++GG+ Sbjct: 240 AQVRGVAWNMDGGW 253 >4RZH-A nrPDB Length = 247 Score = 80.9 bits (198), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 116/247 (46%), Gaps = 16/247 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVA-VSRTQADLDSLVRE--CPGIEPVCVDL 61 L + LVTGA +GIG+ T AL ATG +VV +++ D++V E G E + V Sbjct: 4 LTAQVALVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQA 63 Query: 62 GDWEATE------RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 A E L +D+LVNNA + L + E + ++NL V + Sbjct: 64 NVANADEVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLCT 123 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V++ L+ + G I+N++S + Y + K + TK +A EL + VN Sbjct: 124 KAVSK-LMLKQKSGRIINITSVAGMMGNPGQANYSAAKAGVIGFTKTVAKELASRGVTVN 182 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTGST 234 AV P + T M + ++P +L IPL ++ + E V I FL +D + TG T Sbjct: 183 AVAPGFIATDMTENLNAEP-----ILQFIPLARYGQPEEVAGTIRFLATDPAAAYITGQT 237 Query: 235 LPVEGGF 241 V+GG Sbjct: 238 FNVDGGM 244 >4DBZ-A nrPDB Length = 281 Score = 80.5 bits (197), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 76/251 (30%), Positives = 118/251 (47%), Gaps = 22/251 (8%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEP---VCVDLGDWE 65 LVTGA GIG + L G RV +R + L + ++E G+E C D+ Sbjct: 30 LVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGVEADGRTC-DVRSVP 88 Query: 66 ATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV--A 119 E + +V GPVD+LVNNA E+ E + E NL V +V++ V A Sbjct: 89 EIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTKQVLKA 148 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 G++ RG G IVN++S ++ + + + Y ++K + TK + LEL I VNAV P Sbjct: 149 GGMLERGT-GRIVNIASTGGKQGLVHAAPYSASKHGVVGFTKALGLELARTGITVNAVCP 207 Query: 180 TVVMTSMGQAT---WSDPHKAKT------MLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 V T M + +SD + T + R+P+G++ + V + +L+ + Sbjct: 208 GFVETPMAASVREHYSDIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAV 267 Query: 231 TGSTLPVEGGF 241 T L V GG Sbjct: 268 TAQALNVCGGL 278 >2AG5-A nrPDB Length = 246 Score = 80.5 bits (197), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 122/244 (50%), Gaps = 8/244 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+ +++T A +GIG+ A GA+V+A ++ L L + PGI+ +D+ Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL-EKYPGIQTRVLDVTKK 62 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 + ++ V +D+L N A L+ ++ +D S +N+R++ + + ++A Sbjct: 63 KQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLA 122 Query: 125 RGVPGAIVNVSSQCSQ-RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 + G I+N+SS S + V N VY +TK A+ LTK +A + IR N V P V Sbjct: 123 QK-SGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVD 181 Query: 184 TSMGQATWS---DPHKAKT-MLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 T Q +P +A+ L R G+FA E + ++L SD S TG+ + ++G Sbjct: 182 TPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDG 241 Query: 240 GFWA 243 G W+ Sbjct: 242 G-WS 244 >4DMM-A nrPDB Length = 269 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 70/249 (28%), Positives = 109/249 (43%), Gaps = 16/249 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC---- 58 L L R LVTGA +GIGR L A GA+V + A V Sbjct: 24 LPLTDRIALVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAV 83 Query: 59 -VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ E +V G +D+LVNNA + L + ++ + ++NL V Sbjct: 84 KADVSQESEVEALFAAVIERWGRLDVLVNNAGITRDTLLLRMKRDDWQSVLDLNLGGVFL 143 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 S+ A+ ++ + G I+N++S + + Y + K + LTK +A EL I Sbjct: 144 CSRAAAK-IMLKQRSGRIINIASVVGEMGNPGQANYSAAKAGVIGLTKTVAKELASRGIT 202 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTG 232 VNAV P + T M + A+ +L IPLG++ E V + FL +D + TG Sbjct: 203 VNAVAPGFIATDM-----TSELAAEKLLEVIPLGRYGEAAEVAGVVRFLAADPAAAYITG 257 Query: 233 STLPVEGGF 241 + ++GG Sbjct: 258 QVINIDGGL 266 >2B4Q-A nrPDB Length = 276 Score = 79.3 bits (194), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 112/249 (44%), Gaps = 13/249 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ---ADLDSLVRECPGIEPVCVDL 61 LAGR LVTG +GIG+ Q L GARV +R AD + + + + DL Sbjct: 27 LAGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQAIPADL 86 Query: 62 GDWEATER---ALGSVGP-VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI----Q 113 R ALG + +D+LVNNA + +++ ++N+ +V Q Sbjct: 87 SSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFSCIQQ 146 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELGPHKI 172 + ++ R A P ++N+ S A+ + Y +K AL L++++A EL I Sbjct: 147 LLPLLRRSASAEN-PARVINIGSVAGISAMGEQAYAYGPSKAALHQLSRMLAKELVGEHI 205 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 VN + P + M + +DP + IP+G++ E + + L TG Sbjct: 206 NVNVIAPGRFPSRMTRHIANDPQALEADSASIPMGRWGRPEEMAALAISLAGTAGAYMTG 265 Query: 233 STLPVEGGF 241 + +P++GGF Sbjct: 266 NVIPIDGGF 274 >4RZI-B nrPDB Length = 240 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/241 (29%), Positives = 107/241 (44%), Gaps = 8/241 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 + L L + ++VTG +GIG V+ L GA+V + T D E G+ D Sbjct: 2 LSLGLEDKVIVVTGGNRGIGAAIVKLLQEMGAKV---AFTDLATDGGNTEALGVVANVTD 58 Query: 61 LGDWEATERAL-GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 L A + +GPV +V NA + F ++T +D VNL+ V + Sbjct: 59 LESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAYSIKPFI 118 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 G+ R G+IV +SS +R + Y +TK + + K +A E + +R NAV P Sbjct: 119 EGMYERKA-GSIVAISSISGERGNVGQTNYSATKAGVIGMMKSLAREGARYGVRANAVAP 177 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTGSTLPVE 238 + T M A D + T IP +F + E + A+ FLLS S TG L V Sbjct: 178 GFIDTEMTLAIREDIREKIT--KEIPFRRFGKPEEIAWAVAFLLSPVASSYVTGEVLRVN 235 Query: 239 G 239 G Sbjct: 236 G 236 >1O5I-A nrPDB Length = 249 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 109/241 (45%), Gaps = 9/241 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 MEL + + VLV A +GIGR L GA V +R + L G V D Sbjct: 13 MELGIRDKGVLVLAASRGIGRAVADVLSQEGAEVTICARNEELLKR-----SGHRYVVCD 67 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 L + + V VD+LV NA F E+T E F + + +I++ + Sbjct: 68 LR--KDLDLLFEKVKEVDILVLNAGGPKAGFFDELTNEDFKEAIDSLFLNMIKIVRNYLP 125 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 + +G G IV ++S + N S + AL K ++ E+ P+ I VN V P Sbjct: 126 AMKEKGW-GRIVAITSFSVISPIENLYTSNSARMALTGFLKTLSFEVAPYGITVNCVAPG 184 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 T + S+ K K + ++IP+ + A+ E + + + FL S+++ TG T+ V+GG Sbjct: 185 WTETERVKELLSE-EKKKQVESQIPMRRMAKPEEIASVVAFLCSEKASYLTGQTIVVDGG 243 Query: 241 F 241 Sbjct: 244 L 244 >4IS3-A nrPDB Length = 268 Score = 76.6 bits (187), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 107/241 (44%), Gaps = 13/241 (5%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP------VCVDLGDW 64 ++TG +GIG + GA+V TQ ++D+ + + + P DL Sbjct: 29 IITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSR 88 Query: 65 EATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 +A A+G V G +D+++NNA + F V++E F ++N+ V A Sbjct: 89 DAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFN-GAWCAY 147 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 + G I+N +S + Y ++K ++ LT + E+ IRV V P Sbjct: 148 QCMKDAKKGVIINTASVTGIFGSLSGVGYPASKASVIGLTHGLGREIIRKNIRVVGVAPG 207 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 VV T M + P + L +P+ + E E + N LFL SD + T +T+ V+G Sbjct: 208 VVNTDM--TNGNPPEIMEGYLKALPMKRMLEPEEIANVYLFLASDLASGITATTVSVDGA 265 Query: 241 F 241 + Sbjct: 266 Y 266 >3UVE-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 77/273 (28%), Positives = 121/273 (44%), Gaps = 40/273 (14%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAV----------------SRTQADLDSLVRE 50 G+ VTGA +G GR L GA ++AV + T DL Sbjct: 11 GKVAFVTGAARGQGRSHAVRLAQEGADIIAVDICKPIRAGVVDTAIPASTPEDLAETADL 70 Query: 51 CPG----IEPVCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVT-KEAFD 101 G I VD+ D++A + A+ S +G +D++V NA + L+ T +E + Sbjct: 71 VKGHNRRIVTAEVDVRDYDALKAAVDSGVEQLGRLDIIVANAGIGNGGDTLDKTSEEDWT 130 Query: 102 RSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK 161 ++NL V + + +IA G G+I+ SS +A + Y + K + L + Sbjct: 131 EMIDINLAGVWKTVKAGVPHMIAGGRGGSIILTSSVGGLKAYPHTGHYVAAKHGVVGLMR 190 Query: 162 VMALELGPHKIRVNAVNPTVVMTSM--GQATW------------SDPHKAKTMLNRIPLG 207 +ELG H IRVN+V+PT V T M + T+ D M + +P+ Sbjct: 191 AFGVELGQHMIRVNSVHPTHVKTPMLHNEGTFKMFRPDLENPGPDDMAPICQMFHTLPI- 249 Query: 208 KFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + E + NA+LF SD + TG TLP++ G Sbjct: 250 PWVEPIDISNAVLFFASDEARYITGVTLPIDAG 282 >2BFA-A nrPDB Length = 288 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/279 (27%), Positives = 120/279 (43%), Gaps = 53/279 (18%) Query: 11 LVTGAGKGIGRGTVQALHATG-----------ARVVAVSRT------------QADLDSL 47 LVTGA K +GR + LHA G A A+S T QADL ++ Sbjct: 10 LVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNV 69 Query: 48 ----VRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFD-- 101 V G PV + E G D+LVNNA+ P L ++ + Sbjct: 70 ATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPC 129 Query: 102 ----RSFEVNLRAVIQVSQIVARGLIA-------------RGVPGAIVNVSSQCSQRAVT 144 + E + + I LI RG +I+N+ + + + Sbjct: 130 VGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLL 189 Query: 145 NHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP--TVVMTSMGQATWSDPHKAKTMLN 202 +++Y KGAL+ LT+ ALEL P +IRVN V P +V++ M A W + H++K L Sbjct: 190 GYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVW-EGHRSKVPLY 248 Query: 203 RIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + + + V + ++FL S ++ TG+ + V+GG+ Sbjct: 249 Q----RDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGY 283 >2QHX-A nrPDB Length = 328 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/279 (27%), Positives = 120/279 (43%), Gaps = 53/279 (18%) Query: 11 LVTGAGKGIGRGTVQALHATG-----------ARVVAVSRT------------QADLDSL 47 LVTGA K +GR + LHA G A A+S T QADL ++ Sbjct: 50 LVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNV 109 Query: 48 ----VRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFD-- 101 V G PV + E G D+LVNNA+ P L ++ + Sbjct: 110 ATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPC 169 Query: 102 ----RSFEVNLRAVIQVSQIVARGLIA-------------RGVPGAIVNVSSQCSQRAVT 144 + E + + I LI RG +I+N+ + + + Sbjct: 170 VGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLL 229 Query: 145 NHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP--TVVMTSMGQATWSDPHKAKTMLN 202 +++Y KGAL+ LT+ ALEL P +IRVN V P +V++ M A W + H++K L Sbjct: 230 GYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVW-EGHRSKVPLY 288 Query: 203 RIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + + + V + ++FL S ++ TG+ + V+GG+ Sbjct: 289 Q----RDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGY 323 >2X9N-A nrPDB Length = 288 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 118/268 (44%), Gaps = 48/268 (17%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADL-----DSLVRECPGIEPVC-VDLGD- 63 +VTGA K IGR LH TG RVV A+ D L +E VC DL + Sbjct: 27 VVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNS 86 Query: 64 -------WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV-IQVS 115 E + G D+LVNNA+ P ++ E D S N + V QV+ Sbjct: 87 NVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHE--DNS---NGKTVETQVA 141 Query: 116 QIVARGLIA------------RGV-PG------AIVNVSSQCSQRAVTNHSVYCSTKGAL 156 +++ IA +G P +IVN+ + S+Y K AL Sbjct: 142 ELIGTNAIAPFLLTMSFAQRQKGTNPNCTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHAL 201 Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVM--TSMGQATWSDPHKAKTMLNRIPLGKF-AEVE 213 LT+ ALEL P+ IRVN V P V + +MG+ + ++PLG+ A E Sbjct: 202 VGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGE------EEKDKWRRKVPLGRREASAE 255 Query: 214 HVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + +A++FL+S + TGS + V+GG Sbjct: 256 QIADAVIFLVSGSAQYITGSIIKVDGGL 283 >4RGB-A nrPDB Length = 294 Score = 74.3 bits (181), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 77/268 (28%), Positives = 108/268 (40%), Gaps = 31/268 (11%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLVR--E 50 L GR V +TGA +G GR GA +V V T +L+ R E Sbjct: 23 LDGRVVFITGAARGQGRSHAVMCAEQGANIVGVDICEDIDIVPYKLGTYEELEETARLVE 82 Query: 51 CPGIEPVC--VDLGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSF 104 G E + D+ D E + + G +D ++ NA V L P EA Sbjct: 83 KTGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIANAGVVLTNPDERDASEALRLGL 142 Query: 105 EVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTN----HSVYCSTKGALDMLT 160 ++ L V Q+ + RG G ++ SS + +T+ Y ++K A+ L Sbjct: 143 DIMLIGVWNTFQVAIPHMKERGQGGNLIATSSMIALLDLTDGRGGTDAYLTSKLAITGLV 202 Query: 161 KVMALELGPHKIRVNAVNPTVVMTSM-------GQATWSDPHKAKTMLNRIPLGKFAEVE 213 + AL L +IRVN V PT T M + +PH M +P E Sbjct: 203 RSYALMLAADRIRVNGVAPTNCSTPMITENPALFKVIEENPHLVNAMSTALPDFPMIEPR 262 Query: 214 HVVNAILFLLSDRSGMTTGSTLPVEGGF 241 V NAILFL+SD TGS L V+ G Sbjct: 263 DVSNAILFLISDAGRSFTGSVLKVDAGM 290 >4IIV-A nrPDB Length = 267 Score = 74.3 bits (181), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 67/243 (27%), Positives = 105/243 (43%), Gaps = 12/243 (4%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARV-VAVSR----TQADLDSLVRECPGIEPVCVDLG 62 R VLVTGA KGIGR + L A G + V R Q L+++V + D+ Sbjct: 27 RSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNGRLLSFDVA 86 Query: 63 DWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + E E + G +V+NA +A F ++ + +D NL + V Q Sbjct: 87 NREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDSFYNVIQPC 146 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 +I G I+ +SS Y + K + TK +A+EL KI VN + Sbjct: 147 IMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGIIGATKALAIELAKRKITVNCIA 206 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P ++ T M + S +A +M IP+ + + E V +L+SD +G T + + Sbjct: 207 PGLIDTGMIEMEESALKEAMSM---IPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISIN 263 Query: 239 GGF 241 GG Sbjct: 264 GGM 266 >2CDH-G nrPDB Length = 244 Score = 73.6 bits (179), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 108/242 (44%), Gaps = 13/242 (5%) Query: 10 VLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSLVRECPGIEPVCVDLG------ 62 V+VTGA +GIG+ +L G +V V +R+ + + ++ + G Sbjct: 4 VVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITFGGDVSKE 63 Query: 63 -DWEATER-ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 D EA + A+ + G +D++VNNA + + + K +D ++NL V +Q + Sbjct: 64 ADVEAMMKTAIDAWGTIDVVVNNAGITRDTLLIRMKKSQWDEVIDLNLTGVFLCTQAATK 123 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 ++ + G I+N++S + Y + K + +K A E I VN V P Sbjct: 124 -IMMKKRKGRIINIASVVGLIGNIGQANYAAAKAGVIGFSKTAAREGASRNINVNVVCPG 182 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFL-LSDRSGMTTGSTLPVEG 239 + + M D K +L IPLG+ + E+V + FL LS + TG ++G Sbjct: 183 FIASDMTAKLGEDME--KKILGTIPLGRTGQPENVAGLVEFLALSPAASYITGQAFTIDG 240 Query: 240 GF 241 G Sbjct: 241 GI 242 >1X1T-A nrPDB Length = 260 Score = 73.6 bits (179), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 79/263 (30%), Positives = 117/263 (44%), Gaps = 27/263 (10%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC----PGIEPVC- 58 L G+ +VTG+ GIG G AL A GA +V A VR G++ + Sbjct: 1 MLKGKVAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLAAQHGVKVLYD 60 Query: 59 -VDLGDWEAT----ERALGSVGPVDLLVNNAAV---ALLQPFLEVTKEAFDRSFEVNLRA 110 DL EA + A+ +G +D+LVNNA + AL++ F E +D +NL A Sbjct: 61 GADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIEDF---PTEKWDAILALNLSA 117 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 V + + +G G I+N++S A N S Y + K + TKV ALE Sbjct: 118 VFHGTAAALPHMKKQGF-GRIINIASAHGLVASANKSAYVAAKHGVVGFTKVTALETAGQ 176 Query: 171 KIRVNAVNPTVVMT--------SMGQATWSDPHKAKTML--NRIPLGKFAEVEHVVNAIL 220 I NA+ P V T ++ + D A L + P +F E + + Sbjct: 177 GITANAICPGWVRTPLVEKQISALAEKNGVDQETAARELLSEKQPSLQFVTPEQLGGTAV 236 Query: 221 FLLSDRSGMTTGSTLPVEGGFWA 243 FL SD + TG+T+ V+GG+ A Sbjct: 237 FLASDAAAQITGTTVSVDGGWTA 259 >3W8F-A nrPDB Length = 260 Score = 73.6 bits (179), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 76/264 (28%), Positives = 120/264 (45%), Gaps = 29/264 (10%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVV--------AVSRTQADLDSLVRECPGIE 55 L G++ +VTG+ GIG L GA VV + R ++ L+S G++ Sbjct: 1 MLKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLESKF----GVK 56 Query: 56 PVCV--DLGDWEATE----RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109 + DL D +AT +A ++G +D+LVNNA + P E + ++ +NL Sbjct: 57 AYYLNADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIEEFPVDKWNAIIALNLS 116 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 AV A ++ + G I+N++S A N S Y + K + LTKV ALE Sbjct: 117 AVFH-GTAAALPIMQKQGWGRIINIASAHGLVASVNKSAYVAAKHGVVGLTKVTALENAG 175 Query: 170 HKIRVNAVNPTVVMT--------SMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAI 219 I NA+ P V T ++ Q D A + + + P +F E + A Sbjct: 176 KGITCNAICPGWVRTPLVEKQIEAISQQKGIDIEAAARELLAEKQPSLQFVTPEQLGGAA 235 Query: 220 LFLLSDRSGMTTGSTLPVEGGFWA 243 +FL S + TG+TL ++GG+ A Sbjct: 236 VFLSSAAADQMTGTTLSLDGGWTA 259 >4DA9-A nrPDB Length = 280 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 24/242 (9%) Query: 6 AGRRVLVTGAGKGIGRGTVQA-LHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 +G + +TG G G V A L GARV+ + +ADL DL Sbjct: 52 SGFDIAITGIGDAEGVAPVIAELSGLGARVIFL---RADL--------------ADLSSH 94 Query: 65 EAT-ERALGSVGPVDLLVNNAAVALL--QPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 +AT + + G +D LVNNA +A + FL++ E FD VNLR + +Q V + Sbjct: 95 QATVDAVVAEFGRIDCLVNNAGIASIVRDDFLDLKPENFDTIVGVNLRGTVFFTQAVLKA 154 Query: 122 LIARGVPGA--IVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 ++A + I+N++S + YC +K L ++ +AL L I V V P Sbjct: 155 MLASDARASRSIINITSVSAVMTSPERLDYCMSKAGLAAFSQGLALRLAETGIAVFEVRP 214 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 ++ + M A S + +P+ ++ E E + N + L + G TGS + +G Sbjct: 215 GIIRSDM-TAAVSGKYDGLIESGLVPMRRWGEPEDIGNIVAGLAGGQFGFATGSVIQADG 273 Query: 240 GF 241 G Sbjct: 274 GL 275 >5O3Z-A nrPDB Length = 263 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/252 (25%), Positives = 115/252 (45%), Gaps = 24/252 (9%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---------ECPGIEPVCVDL 61 +V G G+ +G + L G V +++ + L G + D Sbjct: 10 VVIGGGQTLGAFLCEGLAQAGYHVAVADLNESNANRLADTINSRYGAGRAYGFKVDATDE 69 Query: 62 GDWEATERALG-SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 EA RA+ + G DLLV +A VA P + FD S +VNL S+ ++ Sbjct: 70 ASVEALARAVDETFGRADLLVYSAGVAKAAPITQFRLTDFDLSLQVNLVGYFLCSREFSK 129 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 +I G+ G I+ ++S+ + ++S Y + K LT+ +AL+L + I V+++ Sbjct: 130 LMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVHSLMLG 189 Query: 181 VVMTS-MGQATWSDPHKAKTM-----------LNRIPLGKFAEVEHVVNAILFLLSDRSG 228 ++ S M Q+ P A+ + ++++PL + + + V+N +LF SD++ Sbjct: 190 NLLKSPMFQSLL--PQYAEKLGITPEEVEPYYVDKVPLKRGCDYQDVLNVLLFYASDKAA 247 Query: 229 MTTGSTLPVEGG 240 TG ++ V GG Sbjct: 248 YCTGQSINVTGG 259 >1HXH-A nrPDB Length = 253 Score = 72.0 bits (175), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 119/247 (48%), Gaps = 24/247 (9%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV----- 59 L G+ LVTG G+G V+ L GA+V +A L E G + V Sbjct: 4 LQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAEL-GERSMFVRHDVS 62 Query: 60 DLGDW----EATERALGSVGPVDLLVNNAAVALLQPFLEVTK-EAFDRSFEVNLRAVIQV 114 DW A +R LG+ +++LVNNA + LL +E + E F R ++N +V Sbjct: 63 SEADWTLVMAAVQRRLGT---LNVLVNNAGI-LLPGDMETGRLEDFSRLLKINTESVFIG 118 Query: 115 SQIVARGLIA-RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP--HK 171 Q +G+ A + G+I+N++S S + ++ Y ++K A+ LT+ AL + Sbjct: 119 CQ---QGIAAMKETGGSIINMASVSSWLPIEQYAGYSASKAAVSALTRAAALSCRKQGYA 175 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPL---GKFAEVEHVVNAILFLLSDRSG 228 IRVN+++P + T M QA+ + +L+ L G+ E + +LFL SD S Sbjct: 176 IRVNSIHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQLVLFLASDESS 235 Query: 229 MTTGSTL 235 + +GS L Sbjct: 236 VMSGSEL 242 >3ZV3-A nrPDB Length = 281 Score = 70.9 bits (172), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 72/255 (28%), Positives = 107/255 (41%), Gaps = 31/255 (12%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD- 63 L G L+TG G+GR V A GARV + ++ L L G V V +GD Sbjct: 3 LTGEVALITGGASGLGRALVDRFVAEGARVAVLDKSAERLREL-EVAHGGNAVGV-VGDV 60 Query: 64 ------WEATERALGSVGPVDLLVNNAAV-----ALLQPFLEVTKEAFDRSFEVNLRAVI 112 A ER L + G +D L+ NA + AL + AFD F VN++ I Sbjct: 61 RSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNVKGYI 120 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + L++ G++V S +Y +TK A+ L + MA EL PH + Sbjct: 121 HAVKACLPALVSS--RGSVVFTISNAGFYPNGGGPLYTATKHAVVGLVRQMAFELAPH-V 177 Query: 173 RVNAVNPTVVMTS--------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 RVN V P + T + + + S A + + +P+G+ +E A +F Sbjct: 178 RVNGVAPGGMNTDLRGPSSLGLSEQSISSVPLADMLKSVLPIGRMPALEEYTGAYVFF-- 235 Query: 225 DRSGMTTGSTLPVEG 239 T G +LP G Sbjct: 236 ----ATRGDSLPATG 246 >3V2H-A nrPDB Length = 281 Score = 70.1 bits (170), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 110/256 (42%), Gaps = 21/256 (8%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-LDSLVRECPGIEPVCV-----DL 61 + ++TG+ GIG + L GA +V D + ++ E G+ V D+ Sbjct: 26 KTAVITGSTSGIGLAIARTLAKAGANIVLNGFGAPDEIRTVTDEVAGLSSGTVLHHPADM 85 Query: 62 GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + V G D+LVNNA V ++ + E +DR VNL + + Sbjct: 86 TKPSEIADMMAMVADRFGGADILVNNAGVQFVEKIEDFPVEQWDRIIAVNLSSSFHTIRG 145 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + +G G I+N++S A S Y + K + LTK +ALE+ + VN++ Sbjct: 146 AIPPMKKKGW-GRIINIASAHGLVASPFKSAYVAAKHGIMGLTKTVALEVAESGVTVNSI 204 Query: 178 NPTVVMTSMGQATWSDPHKAK----------TMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 P V+T + + D + + ML P KF VE V + L+L D + Sbjct: 205 CPGYVLTPLVEKQIPDQARTRGITEEQVINEVMLKGQPTKKFITVEQVASLALYLAGDDA 264 Query: 228 GMTTGSTLPVEGGFWA 243 TG+ + ++GG+ A Sbjct: 265 AQITGTHVSMDGGWTA 280 >4JQC-A nrPDB Length = 282 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 121/260 (46%), Gaps = 33/260 (12%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVV----------AVSRTQADLDS-LVRE 50 FL+G+R+LVTG I G QA+H GA + V A L S +V + Sbjct: 23 FLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQ 82 Query: 51 CPGIEPVCVD-----LGD-WEATERALGSVG--PVDLLVNNAAVALLQPFLEVTKEAFDR 102 C E +D LG W + + S+G P D L + A VT+E F Sbjct: 83 CDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNA-------VTREGFKI 135 Query: 103 SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKV 162 + +++ + + +++ R ++ G A++ +S ++RA+ N++V K +L+ + Sbjct: 136 AHDISSYSFVAMAK-ACRSMLNPG--SALLTLSYLGAERAIPNYNVMGLAKASLEANVRY 192 Query: 163 MALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEVEHVVNAILF 221 MA +GP +RVNA++ + T + + D K + P+ + +E V N+ F Sbjct: 193 MANAMGPEGVRVNAISAGPIRT-LAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAF 251 Query: 222 LLSDRSGMTTGSTLPVEGGF 241 L SD S +G + V+GGF Sbjct: 252 LCSDLSAGISGEVVHVDGGF 271 >5CFZ-A nrPDB Length = 305 Score = 69.3 bits (168), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 121/260 (46%), Gaps = 33/260 (12%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVV----------AVSRTQADLDS-LVRE 50 FL+G+R+LVTG I G QA+H GA + V A L S +V + Sbjct: 46 FLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQ 105 Query: 51 CPGIEPVCVD-----LGD-WEATERALGSVG--PVDLLVNNAAVALLQPFLEVTKEAFDR 102 C E +D LG W + + S+G P D L + A VT+E F Sbjct: 106 CDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNA-------VTREGFKI 158 Query: 103 SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKV 162 + +++ + + +++ R ++ G A++ +S ++RA+ N++V K +L+ + Sbjct: 159 AHDISSYSFVAMAK-ACRSMLNPG--SALLTLSYLGAERAIPNYNVMGLAKASLEANVRY 215 Query: 163 MALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEVEHVVNAILF 221 MA +GP +RVNA++ + T + + D K + P+ + +E V N+ F Sbjct: 216 MANAMGPEGVRVNAISAGPIRT-LAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAF 274 Query: 222 LLSDRSGMTTGSTLPVEGGF 241 L SD S +G + V+GGF Sbjct: 275 LCSDLSAGISGEVVHVDGGF 294 >6NRP-A nrPDB Length = 263 Score = 69.3 bits (168), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/243 (27%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-QADLDSLVRECPGI----EPVCVDLG 62 RR+LVTG+ +GIG+ L G V +R+ QA+ + +V+E + + D+ Sbjct: 25 RRILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQNSHYLMFDVN 84 Query: 63 DWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + + ++ L G +V NA + F +T + +D +L V + + Sbjct: 85 ERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDGFYNVLKPL 144 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 +I G IV +SS Y + K L TK +ALEL KI VN V Sbjct: 145 IMPMIHLRKGGRIVTLSSVSGIMGNRGQVNYSAAKAGLIGATKALALELAKRKITVNCVA 204 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P ++ T M +D K L IPL + +V+ V + + FL SD + T + V Sbjct: 205 PGLIETEM----VTDEVKEHA-LKMIPLQRMGQVDEVASVVKFLCSDEASYVTRQVISVN 259 Query: 239 GGF 241 GG Sbjct: 260 GGL 262 >4M89-A nrPDB Length = 261 Score = 68.6 bits (166), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/262 (29%), Positives = 123/262 (46%), Gaps = 36/262 (13%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVV----------AVSRTQADLDS-LVRE 50 FL G+++L+TG + + I G +A GA + V + A+LDS LV Sbjct: 3 FLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFR 62 Query: 51 CP-----GIEPVCVDLGD-WEATERALGSVG--PVDLLVNNAAVALLQPFLE-VTKEAFD 101 C I V DLG W+ + + S+G P + AL FL+ +++EAF+ Sbjct: 63 CDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKE--------ALSGDFLDSISREAFN 114 Query: 102 RSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK 161 + E++ ++ +++ AR ++ RG AIV +S + RA+ N++V K +L+ + Sbjct: 115 TAHEISAYSLPALAK-AARPMM-RGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIR 172 Query: 162 VMALELGPHKIRVNAVN--PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAI 219 A LG IR N ++ P + + G A + N PL + +E V N Sbjct: 173 FTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHN--PLRRNVTIEEVGNTA 230 Query: 220 LFLLSDRSGMTTGSTLPVEGGF 241 FLLSD S TG V+GG+ Sbjct: 231 AFLLSDLSSGITGEITYVDGGY 252 >1YXM-A nrPDB Length = 303 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 109/253 (43%), Gaps = 19/253 (7%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---------I 54 L G+ +VTG GIG+ V+ L G+ VV SR L S E + Sbjct: 15 LLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARV 74 Query: 55 EPVCVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 P+ ++ + E + L + G ++ LVNN L P ++ + + E NL Sbjct: 75 IPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTG 134 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYC-STKGALDMLTKVMALELGP 169 + + V + + G+IVN+ +A +V+ + + + LTK +ALE Sbjct: 135 TFYMCKAVYSSWM-KEHGGSIVNII--VPTKAGFPLAVHSGAARAGVYNLTKSLALEWAC 191 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 IR+N V P V+ + + ++ + +IP + E V + + FLLS + Sbjct: 192 SGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAA 251 Query: 228 GMTTGSTLPVEGG 240 TG ++ V+GG Sbjct: 252 SFITGQSVDVDGG 264 >1BDB-A nrPDB Length = 277 Score = 68.2 bits (165), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 108/258 (41%), Gaps = 26/258 (10%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD- 63 L G VL+TG G+GR V A GA+V + ++ L L E + V +GD Sbjct: 3 LKGEAVLITGGASGLGRALVDRFVAEGAKVAVLDKSAERLAEL--ETDHGDNVLGIVGDV 60 Query: 64 ------WEATERALGSVGPVDLLVNNAAV-----ALLQPFLEVTKEAFDRSFEVNLRAVI 112 +A R + G +D L+ NA + AL+ E AFD F +N++ I Sbjct: 61 RSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYI 120 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + L+A G ++ S +Y + K A+ L + +A EL P+ + Sbjct: 121 HAVKACLPALVAS--RGNVIFTISNAGFYPNGGGPLYTAAKHAIVGLVRELAFELAPY-V 177 Query: 173 RVNAVNPTVVMTS--------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 RVN V + + MG S A + + +P+G+ EVE A +F + Sbjct: 178 RVNGVGSGGINSDLRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEEYTGAYVFFAT 237 Query: 225 -DRSGMTTGSTLPVEGGF 241 + TG+ L +GG Sbjct: 238 RGDAAPATGALLNYDGGL 255 >5JS6-A nrPDB Length = 274 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 108/227 (47%), Gaps = 14/227 (6%) Query: 24 VQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE----RALGSVGPVDL 79 V+A +GARVV + ++ +L +E PG + D+ + + + G +D Sbjct: 28 VRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDC 87 Query: 80 LVNNAA-VALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQC 138 +VNNA Q E + + F + E+NL ++++ L R G ++N+SS Sbjct: 88 VVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYL--RKSQGNVINISSLV 145 Query: 139 SQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPH 195 Y +TKGA+ +TK +AL+ P+ +RVN ++P + T + + A DP Sbjct: 146 GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPR 205 Query: 196 KA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + ML + PLG+ + V A +FL S+ + TG L V GG Sbjct: 206 ATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIELLVTGG 250 >1P33-A nrPDB Length = 289 Score = 65.1 bits (157), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/282 (27%), Positives = 119/282 (42%), Gaps = 59/282 (20%) Query: 11 LVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSLVRECPGIEP-----VCVDLGD- 63 LVTGA K +G +ALHA G V + R+ AD +L P V DL + Sbjct: 11 LVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNV 70 Query: 64 -WEATERALGSV-------------------GPVDLLVNNAAVALLQPFLEVTKEAFD-- 101 + GSV G D+LVNNA+ P L K+A + Sbjct: 71 ATASFSETDGSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLR--KDAGEGG 128 Query: 102 ------RSFEVNLRAVIQVSQIVARGLIA-------------RGVPGAIVNVSSQCSQRA 142 S EV + + I LI RG +IVN+ + + Sbjct: 129 SSVGDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQP 188 Query: 143 VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP--TVVMTSMGQATWSDPHKAKTM 200 + +++Y K AL+ LT+ ALEL +IRVN V+P +V+ M + D + Sbjct: 189 LLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRR---- 244 Query: 201 LNRIPL-GKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 ++PL + + E V + ++FL S ++ TG+ + V+GG+ Sbjct: 245 --KVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGY 284 >2P91-A nrPDB Length = 285 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 126/253 (49%), Gaps = 21/253 (8%) Query: 5 LAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP---GIEPVC- 58 L G+R L+TG + I G ++ H GA++ A + L+ VRE G + V Sbjct: 19 LEGKRALITGVANERSIAYGIAKSFHREGAQL-AFTYATPKLEKRVREIAKGFGSDLVVK 77 Query: 59 --VDLG-DWEATERALG-SVGPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRA 110 V L D + ++ L + G +D++V++ A A + F ++ ++E F + ++++ + Sbjct: 78 CDVSLDEDIKNLKKFLEENWGSLDIIVHSIAYAPKEEFKGGVIDTSREGFKIAMDISVYS 137 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 +I +++ + + G GAIV +S +++ V +++V K AL+ + +A ++ H Sbjct: 138 LIALTRELLP--LMEGRNGAIVTLSYYGAEKVVPHYNVMGIAKAALESTVRYLAYDIAKH 195 Query: 171 KIRVNAVN--PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 R+NA++ P + + + + T +N P GK +E V + +FL SD + Sbjct: 196 GHRINAISAGPVKTLAAYSITGFHLLMEHTTKVN--PFGKPITIEDVGDTAVFLCSDWAR 253 Query: 229 MTTGSTLPVEGGF 241 TG + V+ G+ Sbjct: 254 AITGEVVHVDNGY 266 >4ALL-A nrPDB Length = 277 Score = 64.3 bits (155), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 112/241 (46%), Gaps = 16/241 (6%) Query: 17 KGIGRGTVQALHATGARVVAV---SRTQADLDSLVREC--PGIEPVCVDLGDWEAT---- 67 + I G + L GA++V R++ +L+ L+ + P +D+ E Sbjct: 39 RSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGF 98 Query: 68 ERALGSVGPVDLLVNNAAVALLQP----FLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 E+ VG +D + ++ A A ++ F E ++E F + +++ ++ V+ A+ L+ Sbjct: 99 EQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAH-EAKKLM 157 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 G G+IV + + AV N++V K +L+ K +AL+LGP IRVNA++ + Sbjct: 158 PEG--GSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIR 215 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243 T + K + R PL + + V +LLSD S TG + V+ GF A Sbjct: 216 TLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHA 275 Query: 244 C 244 Sbjct: 276 I 276 >3U5T-A nrPDB Length = 267 Score = 64.3 bits (155), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 98/240 (40%), Gaps = 13/240 (5%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---ECPGIEPVCV--DLGDWE 65 +VTGA +GIG L + G VV +A V E G + + D+ D Sbjct: 31 IVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEAAGGKALTAQADVSDPA 90 Query: 66 ATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 A R + G VD+LVNNA + L E FDR VNL+ + A+ Sbjct: 91 AVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTFNTLREAAQR 150 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 L V G I+N+S+ ++ +Y + K ++ +T V++ EL I VNAV P Sbjct: 151 LR---VGGRIINMSTSQVGLLHPSYGIYAAAKAGVEAMTHVLSKELRGRDITVNAVAPGP 207 Query: 182 VMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T + SD + + PL + + + A+ FL G L GG Sbjct: 208 TATDLFLEGKSDEVRDR-FAKLAPLERLGTPQDIAGAVAFLAGPDGAWVNGQVLRANGGI 266 >2BGM-A nrPDB Length = 278 Score = 63.2 bits (152), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 50/175 (28%), Positives = 87/175 (49%), Gaps = 11/175 (6%) Query: 75 GPVDLLVNNAAVALLQPF--LEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIV 132 G +D++ N V P+ LE E F R ++N+ V++ AR +I G+IV Sbjct: 91 GKLDIMFGNVGVLSTTPYSILEAGNEDFKRVMDINVYGAFLVAKHAARVMIP-AKKGSIV 149 Query: 133 ---NVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQA 189 ++SS + V++ VY +TK A+ LT + ELG + IRVN V+P +V + + Sbjct: 150 FTASISSFTAGEGVSH--VYTATKHAVLGLTTSLCTELGEYGIRVNCVSPYIVASPLLTD 207 Query: 190 TWS-DPHKAKTMLNRIP--LGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 + D + + + ++ G E V +A+ +L D S +G L ++GG+ Sbjct: 208 VFGVDSSRVEELAHQAANLKGTLLRAEDVADAVAYLAGDESKYVSGLNLVIDGGY 262 >5TF4-A nrPDB Length = 274 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/251 (23%), Positives = 117/251 (46%), Gaps = 16/251 (6%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 L G+R L+ G + I G + + GA + + +A ++ L E G Sbjct: 9 LLYGKRGLILGLANNRSIAWGIAKTASSAGAELAFTYQGEAMKKRVEPLAEEVKGFVCGH 68 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLRA 110 D+ D + + ++ G +D LV+ + L ++++++ F + +++ + Sbjct: 69 CDVSDSASIDAVFNTIEKKWGKLDFLVHAIGFSDKEELSGRYVDISESNFMMTMNISVYS 128 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + +++ A L++ G G+I+ ++ +++ V N++V K AL+ K +A++LGP Sbjct: 129 LTALTK-RAEKLMSDG--GSILTLTYYGAEKVVPNYNVMGVAKAALEASVKYLAVDLGPK 185 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRVNA++ + T + K PL + +E V ++ L+LLSD S Sbjct: 186 HIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDSALYLLSDLSRSV 245 Query: 231 TGSTLPVEGGF 241 TG V+ G+ Sbjct: 246 TGEVHHVDSGY 256 >4J3F-A nrPDB Length = 280 Score = 62.8 bits (151), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/254 (25%), Positives = 124/254 (48%), Gaps = 21/254 (8%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPV---- 57 FLAG+++L+TG + K I G +A+H GA +A + D + + C P Sbjct: 23 FLAGKKILITGLLSNKSIAYGIAKAMHREGAE-LAFTYVGQFKDRVEKLCAEFNPAAVLP 81 Query: 58 CVDLGDWEATER--ALGSV-GPVDLLVNNAAVA----LLQPFLE-VTKEAFDRSFEVNLR 109 C + D E + LG V +D +V++ A A L F++ VT+E F + +++ Sbjct: 82 CDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAY 141 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + +++ R ++ + ++V ++ +++A+ +++ K +L+ + AL LG Sbjct: 142 SFAALAK-EGRSMM-KNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGE 199 Query: 170 HKIRVNAVN--PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 I+VNAV+ P + + G + + M++ PL K ++ V N + FL SD + Sbjct: 200 DGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVS--PLKKNVDIMEVGNTVAFLCSDMA 257 Query: 228 GMTTGSTLPVEGGF 241 TG + V+ G+ Sbjct: 258 TGITGEVVHVDAGY 271 >2PD3-A nrPDB Length = 275 Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 122/254 (48%), Gaps = 22/254 (8%) Query: 4 FLAGRRVLVTGA--GKGIGRGTVQALHATGARVVAVSRTQADLDSLVR----ECPGIEPV 57 FL G++ L+ G K I G Q+ GA +A + L+ VR E Sbjct: 3 FLKGKKGLIVGVANNKSIAYGIAQSCFNQGA-TLAFTYLNESLEKRVRPIAQELNSPYVY 61 Query: 58 CVDLGDWEATERALGSV----GPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLR 109 +D+ E + SV G +D +V++ A A L LE +K AF+ + E+++ Sbjct: 62 ELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVY 121 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 ++I+++ + + L+ G +++ +S S + + +++V K AL+ + +A++LG Sbjct: 122 SLIELTNTL-KPLLNNG--ASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGK 178 Query: 170 HKIRVNAVN--PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 H IRVNA++ P + S G A + K + PL K +E V NA ++LLS S Sbjct: 179 HHIRVNALSAGPIRTLASSGIADFRMILKWNEI--NAPLRKNVSLEEVGNAGMYLLSSLS 236 Query: 228 GMTTGSTLPVEGGF 241 +G V+ G+ Sbjct: 237 SGVSGEVHFVDAGY 250 >3RKU-A nrPDB Length = 287 Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 67/247 (27%), Positives = 111/247 (44%), Gaps = 21/247 (8%) Query: 5 LAGRRVLVTGAGKGIGRGT-VQALHATGA--RVVAVSRTQADLDSLVR----ECPGIEPV 57 LA + VL+TGA GIG+ T ++ L A+ +++ +R L+ L + E P + Sbjct: 31 LAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVH 90 Query: 58 CVDLGDWEAT------ERALGSVGPVDLLVNNAAVALLQPFL-EVTKEAFDRSFEVNLRA 110 L +A E +D+LVNNA AL + ++ E F+ N+ A Sbjct: 91 VAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTA 150 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 +I ++Q V A+ G IVN+ S + A S+YC++K A+ T + EL Sbjct: 151 LINITQAVLPIFQAKN-SGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINT 209 Query: 171 KIRVNAVNPTVVMTSMGQATW-SDPHKAKTML-NRIPLGKFAEVEHVVNAILFLLSDRSG 228 KIRV + P +V T + + +AK + + PL + V + I++ S + Sbjct: 210 KIRVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPL----MADDVADLIVYATSRKQN 265 Query: 229 MTTGSTL 235 TL Sbjct: 266 TVIADTL 272 >4NK4-A nrPDB Length = 301 Score = 61.2 bits (147), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/257 (25%), Positives = 113/257 (43%), Gaps = 30/257 (11%) Query: 5 LAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA------------DLDSLVRE 50 L G+R L+ G I G + LH+ GA++ + ++ D D ++ Sbjct: 39 LKGKRGLIMGVANDHSIAWGIAKVLHSAGAQLAFSYQGESIGKRLKPLALTVDSDFMI-P 97 Query: 51 CPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEV 106 C +P +DL ER +D +V++ A + L P+ +++ F + Sbjct: 98 CNVEDPSSMDL----LFERIKERWETLDFVVHSIAFSDKNELRGPYYNTSRDNF---IQT 150 Query: 107 NLRAVIQVSQIVARG--LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164 L + ++IV R L+ G GA++ ++ S R V N++ K AL+ TK +A Sbjct: 151 MLVSCFSFTEIVRRAAQLMPHG--GAMITLTYGGSMRVVPNYNAMAPAKSALESSTKYLA 208 Query: 165 LELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 + G IR+NA++ V T G + + A PL + +E + N+ L+LLS Sbjct: 209 CDYGGMNIRINAISAGPVRTLAGASISNGRDIAAWSKENSPLKRTVSLEDIGNSALYLLS 268 Query: 225 DRSGMTTGSTLPVEGGF 241 S TG V+ G+ Sbjct: 269 YLSNGVTGEIHYVDCGY 285 >5JY1-A nrPDB Length = 274 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 55/182 (30%), Positives = 77/182 (42%), Gaps = 13/182 (7%) Query: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125 A A+ G +D+LVNNA V LE E D E L + + R Sbjct: 81 AVRSAVEQFGSLDILVNNAFVPTPNVLLE---EKTDEMLEQTLTTSLWATWWAMRAAF-- 135 Query: 126 GVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 VP G IVN S ++ H Y + K + LT+ A E G I VNA+ P Sbjct: 136 -VPMRERRWGRIVNFYSIDTETGAWLHGDYNTAKAGIVGLTRSAASEWGRFNITVNAIAP 194 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVN-AILFLLSDRSGMTTGSTLPVE 238 T + + + +P A+ PLG+ + E + A +F S+ S TG TL V+ Sbjct: 195 TAMGATFFELAAKNPEFAERSAAARPLGRSGDPEQDIGPAAVFFASEMSRFVTGETLHVD 254 Query: 239 GG 240 GG Sbjct: 255 GG 256 >3OIG-A nrPDB Length = 266 Score = 60.1 bits (144), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 69/259 (26%), Positives = 112/259 (43%), Gaps = 24/259 (9%) Query: 1 MELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----- 53 M L GR ++V G + I G ++LH GAR++ + L+ V E G Sbjct: 1 MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLI-FTYAGERLEKSVHELAGTLDRN 59 Query: 54 ---IEPVCVDLGDWEATERALGS----VGPVDLLVNNAAVA----LLQPFLEVTKEAFDR 102 I P C D E E S VG + + + A A L+ +L ++ F Sbjct: 60 DSIILP-CDVTNDAE-IETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLL 117 Query: 103 SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKV 162 + ++ ++ V + AR ++ G G+IV ++ + + N++V K +LD K Sbjct: 118 AHNISSYSLTAVVK-AARPMMTEG--GSIVTLTYLGGELVMPNYNVMGVAKASLDASVKY 174 Query: 163 MALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFL 222 +A +LG IRVN+++ + T + K + R PL + E V + FL Sbjct: 175 LAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFL 234 Query: 223 LSDRSGMTTGSTLPVEGGF 241 SD S TG L V+ GF Sbjct: 235 FSDMSRGITGENLHVDSGF 253 >3UCF-A nrPDB Length = 223 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/189 (26%), Positives = 89/189 (47%), Gaps = 18/189 (9%) Query: 59 VDLGDWEATERALGSVGPVD-LLVNNAAVALLQPFLEV----TKEAFDRSFEVNLRAVIQ 113 +D+ D ++ ++G D L+V + A ++V K AFD F + A Sbjct: 42 LDISDEKSVYHYFETIGAFDHLIVTAGSYAPAGKVVDVEVTQAKYAFDTKFWGAVLAAKH 101 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ + +G G+I S S++ V N V + A++ TKV+A EL P IR Sbjct: 102 GARYLKQG-------GSITLTSGMLSRKVVANTYVKAAINAAIEATTKVLAKELAP--IR 152 Query: 174 VNAVNPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 VNA++P + T + +D A + + +P+GK E + A LF + ++ T Sbjct: 153 VNAISPGLTKTEAYKGMNADDRDAMYQRTQSHLPVGKVGEASDIAMAYLFAI--QNSYMT 210 Query: 232 GSTLPVEGG 240 G+ + V+GG Sbjct: 211 GTVIDVDGG 219 >5YCX-A nrPDB Length = 266 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 118/256 (46%), Gaps = 19/256 (7%) Query: 1 MELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVV---AVSRTQADLDSLVRECPGIE 55 MEL L G+ +V G + I G ++LH GA+++ A R + ++ L G E Sbjct: 3 MEL-LQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQE 61 Query: 56 PV---CVDLGDWEAT---ERALGSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFE 105 + C D E T E VG + + + A A L F++ +++ F + Sbjct: 62 SLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQN 121 Query: 106 VNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMAL 165 ++ ++ V++ A+ ++ G G I+ ++ +R V N++V K +L+ K +A Sbjct: 122 ISAFSLTAVAR-EAKKVMTEG--GNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLAN 178 Query: 166 ELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 +LG H IRVNA++ + T + + + R PL + E V + +FL SD Sbjct: 179 DLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSD 238 Query: 226 RSGMTTGSTLPVEGGF 241 + TG + V+ G+ Sbjct: 239 LARGVTGENIHVDSGY 254 >1FJH-A nrPDB Length = 257 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/260 (23%), Positives = 108/260 (41%), Gaps = 39/260 (15%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVS---------------RTQADLDSLVRECPGI 54 ++++G GIG T + L A G ++V + R QA D L + G+ Sbjct: 4 IVISGCATGIGAATRKVLEAAGHQIVGIDIRDAEVIADLSTAEGRKQAIADVLAKCSKGM 63 Query: 55 EPV--CVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 + + C LG + LG+V V+ A L+ FL K+ A + Sbjct: 64 DGLVLCAGLGPQT---KVLGNVVSVNYF---GATELMDAFLPALKKGHQP-------AAV 110 Query: 113 QVSQIVARGLIARGVPGAI-VNVSSQCSQRAVTNHS-------VYCSTKGALDMLTKVMA 164 +S + + L P A+ + + RA+ H+ Y +K AL + + A Sbjct: 111 VISSVASAHLAFDKNPLALALEAGEEAKARAIVEHAGEQGGNLAYAGSKNALTVAVRKRA 170 Query: 165 LELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEVEHVVNAILFLL 223 G +R+N + P T + QA DP +++ + P+G+ AE + + I FL+ Sbjct: 171 AAWGEAGVRLNTIAPGATETPLLQAGLQDPRYGESIAKFVPPMGRRAEPSEMASVIAFLM 230 Query: 224 SDRSGMTTGSTLPVEGGFWA 243 S + G+ + ++GG A Sbjct: 231 SPAASYVHGAQIVIDGGIDA 250 >5KOI-A nrPDB Length = 293 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 44/147 (29%), Positives = 76/147 (51%), Gaps = 5/147 (3%) Query: 96 TKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGA 155 T+E F R+ ++ + +V+Q A L+ G G+I+ ++ S R + N++V K A Sbjct: 131 TRENFSRTMVISAYSFTEVAQ-RAEKLMKDG--GSILTLTYGGSTRTIPNYNVMGVAKAA 187 Query: 156 LDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNR-IPLGKFAEVEH 214 L+ + + +A + GP IRVNA++ V T G A D + R PL + +++ Sbjct: 188 LEAMVRYLAADYGPQGIRVNAISAGPVRTLAG-AGIGDARAIFSYQRRNSPLRRTVDIDD 246 Query: 215 VVNAILFLLSDRSGMTTGSTLPVEGGF 241 V + ++LLSD S TG V+ G+ Sbjct: 247 VGKSAVYLLSDLSSGVTGEIHFVDSGY 273 >1W73-A nrPDB Length = 302 Score = 58.5 bits (140), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 41/168 (24%), Positives = 78/168 (46%), Gaps = 3/168 (1%) Query: 75 GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNV 134 G ++++NNAA + P ++ A+ ++ L V+ + + LI A +++ Sbjct: 103 GHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSI 162 Query: 135 SSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDP 194 ++ ++ S K ++ ++K +A E G + +R N + P + T G + DP Sbjct: 163 TTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTK-GAFSRLDP 221 Query: 195 HKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 K M+ RIP G+ VE + N FL SD + G+ + +GG Sbjct: 222 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGG 269 >4ZJU-A nrPDB Length = 275 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 111/254 (43%), Gaps = 20/254 (7%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAV---SRTQADLD--------SLVRE 50 LAG+R L+ G I G QALH GA + + + +D LV Sbjct: 13 LLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFP 72 Query: 51 CPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVT-KEAFDRSFEVNLR 109 C +D E + G G V + A L F +VT ++ F + +++ Sbjct: 73 CDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAY 132 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + +++ L AR G ++ ++ Q S+R + N++V K +L+ + +A LG Sbjct: 133 SFVAMARAAKPLLQAR--QGCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGV 190 Query: 170 HKIRVNAVN--PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 IRVNA++ P + + G ++ A + PL + +E V NA LFL S + Sbjct: 191 DGIRVNAISAGPIRTLAASGIKSFRKMLDANEKV--APLKRNVTIEEVGNAALFLCSPWA 248 Query: 228 GMTTGSTLPVEGGF 241 TG L V+ GF Sbjct: 249 SGITGEILYVDAGF 262 >2GDZ-A nrPDB Length = 267 Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 93/200 (46%), Gaps = 22/200 (11%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECPGIEP--- 56 M + G+ LVTGA +GIGR +AL GA+V V +A + EP Sbjct: 1 MAHMVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKT 60 Query: 57 --VCVDLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 + D+ D + + + G +D+LVNNA V ++ ++++ ++NL + Sbjct: 61 LFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVS 112 Query: 111 VIQVSQIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMAL--E 166 VI + + + + G G I+N+SS V VYC++K + T+ AL Sbjct: 113 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 172 Query: 167 LGPHKIRVNAVNPTVVMTSM 186 L +R+NA+ P V T++ Sbjct: 173 LMNSGVRLNAICPGFVNTAI 192 >3R3S-A nrPDB Length = 294 Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 112/249 (44%), Gaps = 18/249 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVV-----AVSRTQADLDSLVRECPGIEPVCV 59 L R+ LVTG GIGR A GA V A + +L+ EC G + V + Sbjct: 47 LKDRKALVTGGDSGIGRAAAIAYAREGADVAINYLPAEEEDAQQVKALIEEC-GRKAVLL 105 Query: 60 --DLGDWEATERAL-----GSVGPVDLLVNNAAVALLQPFL-EVTKEAFDRSFEVNLRAV 111 DL D E+ R+L ++G +D+L A P + ++T E F ++F VN+ A+ Sbjct: 106 PGDLSD-ESFARSLVHKAREALGGLDILALVAGKQTAIPEIKDLTSEQFQQTFAVNVFAL 164 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 ++Q A L+ +G +I+ SS + + + Y +TK A+ ++ +A ++ Sbjct: 165 FWITQ-EAIPLLPKGA--SIITTSSIQAYQPSPHLLDYAATKAAILNYSRGLAKQVAEKG 221 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 IRVN V P + T++ + K + P+ + + + ++L S S T Sbjct: 222 IRVNIVAPGPIWTALQISGGQTQDKIPQFGQQTPMKRAGQPAELAPVYVYLASQESSYVT 281 Query: 232 GSTLPVEGG 240 V GG Sbjct: 282 AEVHGVCGG 290 >2YW9-A nrPDB Length = 261 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/254 (26%), Positives = 114/254 (44%), Gaps = 24/254 (9%) Query: 5 LAGRRVLVTGA--GKGIGRGTVQALHATGARV---VAVSRTQADLDSLVRECPGIEPVCV 59 L+G++ LV G + +G L GA V R + + + L G Sbjct: 6 LSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRA 65 Query: 60 DLGDWEATERALGSV----GPVDLLVNNAAVALLQP----FLEVTKEAFDRSFEVNLRAV 111 D+ E + V G +D LV+ A A + +++ ++ + + EV+ ++ Sbjct: 66 DVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSL 125 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 + V++ A L+ G G IV ++ S++ V ++V K AL+ + +A ELGP Sbjct: 126 VAVAR-RAEPLLREG--GGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKG 182 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI----PLGKFAEVEHVVNAILFLLSDRS 227 +RVNA++ V T A S P K M +R+ PL + E V N LFLLS + Sbjct: 183 VRVNAISAGPVRTV---AARSIPGFTK-MYDRVAQTAPLRRNITQEEVGNLGLFLLSPLA 238 Query: 228 GMTTGSTLPVEGGF 241 TG + V+ G+ Sbjct: 239 SGITGEVVYVDAGY 252 >3K2E-A nrPDB Length = 296 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 123/254 (48%), Gaps = 20/254 (7%) Query: 3 LFLAGRRVLVTGAG--KGIGRGTVQALHATGARV--VAVSRTQADLDSLVRECPGIE-PV 57 + + G++ ++ G K + G +A+ A GA V +S T + E G++ V Sbjct: 26 MLMEGKKGVIIGVANDKSLAWGIAKAVCAQGAEVALTYLSETFKKRVDPLAESLGVKLTV 85 Query: 58 CVDLGDWEATERALGSV----GPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLR 109 D+ D E+ + + G +D +V+ A + L +++ + F S ++ Sbjct: 86 PCDVSDAESVDNMFKVLAEEWGSLDFVVHAVAFSDKNELKGRYVDTSLGNFLTSMHISCY 145 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + ++ A L+ G G+I+ +S +++ V +++V K AL+ K +A++LG Sbjct: 146 SFTYIAS-KAEPLMTNG--GSILTLSYYGAEKVVPHYNVMGVCKAALEASVKYLAVDLGK 202 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI--PLGKFAEVEHVVNAILFLLSDRS 227 +IRVNA++ V T + + SD H T N+ PL + ++ V A L+LLSD Sbjct: 203 QQIRVNAISAGPVRT-LASSGISDFHYILTW-NKYNSPLRRNTTLDDVGGAALYLLSDLG 260 Query: 228 GMTTGSTLPVEGGF 241 TTG T+ V+ G+ Sbjct: 261 RGTTGETVHVDCGY 274 >4TRR-A nrPDB Length = 269 Score = 57.4 bits (137), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 103/256 (40%), Gaps = 18/256 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ----ADLDSLVRECPGIEPVCVD 60 L G+ +VTGA GIG+ L GA V Q A D + + V +D Sbjct: 12 LNGKTAVVTGAASGIGKEIALELAKAGAAVAIADLNQDGANAVADEINKAGGKAIGVAMD 71 Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + + EA + V G VD+LV+NA + ++ P + + + +++ ++ Sbjct: 72 VTNEEAVNTGIDKVAEAFGSVDILVSNAGIQIVNPIENYSFADWKKMQAIHVDGAFLTTK 131 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + + G ++ + S S A S Y + K L L +V+A E H +R + Sbjct: 132 AALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAKHGLLGLARVLAKEGAKHNVRSHV 191 Query: 177 VNPTVVMTSMGQATWSDPHK----------AKTMLNRIPLGKFAEVEHVVNAILFLLSDR 226 V P V T + + K K ML G F V+ V +LFL + Sbjct: 192 VCPGFVRTPLVDKQIPEQAKELGISEEEVIKKVMLGNTVDGVFTTVQDVAQTVLFLSAFP 251 Query: 227 SGMTTGSTLPVEGGFW 242 S TG + V G++ Sbjct: 252 SAALTGQSFIVSHGWF 267 >2O23-A nrPDB Length = 265 Score = 57.0 bits (136), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 99/232 (42%), Gaps = 26/232 (11%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVDLGDWE- 65 ++TG G+G T + L GA V + S +A L C D + Sbjct: 16 VITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQT 75 Query: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVIQVSQIVA 119 A A G G VD+ VN A +A+ + K E F R +VNL V ++VA Sbjct: 76 ALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVA 135 Query: 120 RGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 G + + P G I+N +S + + Y ++KG + +T +A +L P IR Sbjct: 136 -GEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIR 194 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220 V + P + T + S P K L +++P LG AE H+V AI+ Sbjct: 195 VMTIAPGLFGTPL---LTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 243 >3GRK-A nrPDB Length = 293 Score = 56.2 bits (134), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/251 (22%), Positives = 111/251 (44%), Gaps = 16/251 (6%) Query: 4 FLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 L G+R L+ G + I G +A GA + + A ++ L E Sbjct: 28 LLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELGAFVAGH 87 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLRA 110 D+ D + + ++ G +D LV+ + L +++ ++ F + +++ + Sbjct: 88 CDVADAASIDAVFETLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTMLISVYS 147 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + VS+ A L+A G G+I+ ++ +++ + N++V K AL+ K +A++LGP Sbjct: 148 LTAVSR-RAEKLMADG--GSILTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDLGPQ 204 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRVNA++ + T + K PL + ++ V + L+ LSD S Sbjct: 205 NIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLSRSV 264 Query: 231 TGSTLPVEGGF 241 TG + G+ Sbjct: 265 TGEVHHADSGY 275 >2DKN-A nrPDB Length = 255 Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/271 (25%), Positives = 105/271 (38%), Gaps = 63/271 (23%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 + +TG+ GIG + L G V+ + R QAD+++ DL E Sbjct: 4 IAITGSASGIGAALKELLARAGHTVIGIDRGQADIEA-------------DLSTPGGRET 50 Query: 70 ALGSV-----GPVDLLVNNAAVAL---------------LQPFLEVTKEAFDRSFEVNLR 109 A+ +V G +D LV A V + + L+ EA R Sbjct: 51 AVAAVLDRCGGVLDGLVCCAGVGVTAANSGLVVAVNYFGVSALLDGLAEALSRG------ 104 Query: 110 AVIQVSQIVARGLIARGVPGAI----------------VNVSSQCSQRAVTNHSVYCSTK 153 Q V G IA PGA + ++ Q Q H Y +K Sbjct: 105 ---QQPAAVIVGSIAATQPGAAELPMVEAMLAGDEARAIELAEQQGQ----THLAYAGSK 157 Query: 154 GALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEV 212 A+ L + ++ +R+N V P V T + QA+ +DP ++ + PLG+ +E Sbjct: 158 YAVTCLARRNVVDWAGRGVRLNVVAPGAVETPLLQASKADPRYGESTRRFVAPLGRGSEP 217 Query: 213 EHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243 V AI FLL ++ GS L V+GG A Sbjct: 218 REVAEAIAFLLGPQASFIHGSVLFVDGGMDA 248 >3GDF-A nrPDB Length = 267 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 113/255 (44%), Gaps = 20/255 (7%) Query: 2 ELFLAGRRVLVTGAG--KGIGRGTVQALHATGARV--VAVSRTQADLDSL--VRECPGIE 55 +L L G+ V+VTGA KG+G + GA V SR Q +++ + + GI+ Sbjct: 15 QLSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVKELEKTYGIK 74 Query: 56 PVCV--DLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109 + +E+ E+ + V G +D + NA L+ + EA++ +V+L Sbjct: 75 AKAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDGSVEAWNHVVQVDLN 134 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAV--TNHSVYCSTKGALDMLTKVMALEL 167 ++ V RG G++V +S A + Y K + + +A E Sbjct: 135 GTFHCAKAVGHHFKERGT-GSLVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEW 193 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNR-IPLGKFAEVEHVVNAILFLLSDR 226 RVN+++P + T + P + + + + IP+G+ + + A ++ SD Sbjct: 194 RDF-ARVNSISPGYIDTGLSDFV---PKETQQLWHSMIPMGRDGLAKELKGAYVYFASDA 249 Query: 227 SGMTTGSTLPVEGGF 241 S TTG+ L ++GG+ Sbjct: 250 STYTTGADLLIDGGY 264 >3U4C-A nrPDB Length = 281 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 96/255 (37%), Gaps = 20/255 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP---VCVDL 61 ++ R V GA +GIG+ L +V SR +++S+ + P V V Sbjct: 21 MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVKEDILAKHPEASVIVLA 80 Query: 62 GDWEATERALG-------SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 GD G G +D+L+NN F E +F A I Sbjct: 81 GDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCNIEDMTATFTQKTVAYIDA 140 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 + A L+ + G I+N+ + N AL +K ++++L PH I V Sbjct: 141 IK-RASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAALINASKNISIQLAPHNITV 199 Query: 175 NAVNPTVVMTS---------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 N +NP + T M + + S + + + IP+ + E FL S+ Sbjct: 200 NCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGIPMKRVGSAEETAALAAFLASE 259 Query: 226 RSGMTTGSTLPVEGG 240 + TG + +GG Sbjct: 260 EASYITGQQISADGG 274 >3PXX-A nrPDB Length = 287 Score = 53.5 bits (127), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 105/277 (37%), Gaps = 53/277 (19%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDS--LVRECPGIE 55 VLVTG +G GR L GA ++ T DL+ L E G + Sbjct: 13 VLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEKTGRK 72 Query: 56 PVC--VDLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109 VD+ D A R A+ G +D++V NA + L L V +AF +F+V+ Sbjct: 73 AYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPV--QAFADAFDVDFV 130 Query: 110 AVIQV-----------SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSV-YCSTKGALD 157 VI + I+ G +A G I + Y K +D Sbjct: 131 GVINTVHAALPYLTSGASIITTGSVA----GLIAAAQPPGAGGPQGPGGAGYSYAKQLVD 186 Query: 158 MLTKVMALELGPHKIRVNAVNPTVVMTSMGQAT---------WSDPHKAKTML-----NR 203 T +A +L P IR N ++PT V T M + P +A +L Sbjct: 187 SYTLQLAAQLAPQSIRANVIHPTNVNTDMLNSAPMYRQFRPDLEAPSRADALLAFPAMQA 246 Query: 204 IPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 +P + E + NA+ FL SD S TG V+ G Sbjct: 247 MPT-PYVEASDISNAVCFLASDESRYVTGLQFKVDAG 282 >5I9N-A nrPDB Length = 276 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/254 (23%), Positives = 103/254 (40%), Gaps = 17/254 (6%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAV---SRTQADLDSLVRECPGIEPVC 58 FL G+R+L+TG + + I G +A GA + R + + E Sbjct: 3 FLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFP 62 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ D + S+ +D LV++ A P + + D N R + Sbjct: 63 CDVADDAQIDALFASLKTHWDSLDGLVHSIGFA---PREAIAGDFLDGLTRENFRIAHDI 119 Query: 115 SQIVARGLIARGVP-----GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 S L +P +++ +S ++RA+ N++ K AL+ + +A+ LG Sbjct: 120 SAYSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGA 179 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 +RVNA++ + T S + + PL + +E V NA FLLSD + Sbjct: 180 KGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASG 239 Query: 230 TTGSTLPVEGGFWA 243 T + V+ GF A Sbjct: 240 VTAEVMHVDSGFNA 253 >3DWF-A nrPDB Length = 276 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 16/192 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PGIEPVCV 59 L G++V+VTGA KGIGR L GA VV +R++ L +V C + Sbjct: 9 LQGKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGAASAHYIAG 68 Query: 60 DLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 + D E + +G +D+L+ N + F + +S EVN + + +S Sbjct: 69 SMEDMTFAEEFVAEAGNLMGGLDMLILNHVLYNRLTFFHGEIDNVRKSMEVNFHSFVVLS 128 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + A ++ + G+I VSS + + Y ++K ALD + E VN Sbjct: 129 -VAAMPMLMQS-QGSIAVVSSVAGKITYPLIAPYSASKFALDGFFSTLRSEF-----LVN 181 Query: 176 AVNPTVVMTSMG 187 VN ++ + +G Sbjct: 182 KVNVSITLCILG 193 >3KZV-A nrPDB Length = 254 Score = 51.2 bits (121), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 54/192 (28%), Positives = 89/192 (46%), Gaps = 20/192 (10%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGAR--VVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 G+ +LVTG +GIG+ V L + V V+R++A L L +E G V +GD Sbjct: 2 GKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKL-KEKYGDRFFYV-VGDI 59 Query: 65 -------EATERALGSVGPVDLLVNNAAVALLQPFLEVTK---EAFDRSFEVNLRAVIQV 114 + A+ G +D LV NA V L+P V + A+ + +++N +++ + Sbjct: 60 TEDSVLKQLVNAAVKGHGKIDSLVANAGV--LEPVQNVNEIDVNAWKKLYDINFFSIVSL 117 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 I L + G +V VSS ++ Y S+K AL+ +A E +++ Sbjct: 118 VGIALPEL--KKTNGNVVFVSSDACNMYFSSWGAYGSSKAALNHFAMTLANE--ERQVKA 173 Query: 175 NAVNPTVVMTSM 186 AV P +V T M Sbjct: 174 IAVAPGIVDTDM 185 >4DRY-A nrPDB Length = 281 Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 66/237 (27%), Positives = 95/237 (40%), Gaps = 33/237 (13%) Query: 16 GKGIGRGTV---------------QALHATGARVVAVSRTQADLDSLVRECPG-----IE 55 GKG G G + QAL A G VV R LD+ E G + Sbjct: 27 GKGSGEGRIALVTGGGTGVGRGIAQALSAEGYSVVITGRRPDVLDAAAGEIGGRTGNIVR 86 Query: 56 PVCVDLGDWEATERALGSV----GPVDLLVNNAAVALLQ-PFLEVTKEAFDRSFEVNLRA 110 V D+GD + +V +DLLVNNA + P EVT E ++ NL Sbjct: 87 AVVCDVGDPDQVAALFAAVRAEFARLDLLVNNAGSNVPPVPLEEVTFEQWNGIVAANLTG 146 Query: 111 VIQVSQIVARGLIA---RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 +Q R + A RG G I+N S +Q N + Y +TK A+ LTK AL+ Sbjct: 147 AFLCTQHAFRMMKAQTPRG--GRIINNGSISAQTPRPNSAPYTATKHAITGLTKSTALDG 204 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 H I ++ T M + +A + P +EH+ A++++ S Sbjct: 205 RMHDIACGQIDIGNAATDMTARMSTGVLQANGEVAAEPT---IPIEHIAEAVVYMAS 258 >1A27-A nrPDB Length = 289 Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 16/212 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--------ECP--GIEPVCV 59 VL+TG GIG L + ++ V T DL + R CP +E + + Sbjct: 5 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 64 Query: 60 DLGDWE--ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D+ D + A R + G VD+LV NA + LL P + ++A +VN+ +++ Q Sbjct: 65 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 124 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + RG G ++ S + + VYC++K AL+ L + +A+ L P + ++ + Sbjct: 125 FLPDMKRRG-SGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLI 183 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKF 209 V T+ + P + +L+R + F Sbjct: 184 ECGPVHTAFMEKVLGSPEE---VLDRTDIHTF 212 >1OAA-A nrPDB Length = 259 Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 95/208 (45%), Gaps = 26/208 (12%) Query: 12 VTGAGKGIGRG---TVQALHATGARVVAVSRTQADLDSLVRECPGIEP------VCVDLG 62 +TGA +G GR + L + G+ ++ +R+++ L L E +P DLG Sbjct: 11 LTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAADLG 70 Query: 63 DWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTKEA-FDRSFEVNLRAV 111 +R L +V + LL+NNAA + + FL V A + + +NL ++ Sbjct: 71 TEAGVQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNLTSM 130 Query: 112 IQVSQIVARGLI-ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + ++ + G+ +VN+SS C+ + +YC+ K A DML +V+A E Sbjct: 131 LCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAE--EP 188 Query: 171 KIRVNAVNPTVV---MTSMGQATWSDPH 195 +RV + P + M + + T DP Sbjct: 189 SVRVLSYAPGPLDNDMQQLARETSKDPE 216 >2NWQ-A nrPDB Length = 272 Score = 50.1 bits (118), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 42/179 (23%), Positives = 79/179 (44%), Gaps = 10/179 (5%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---IEPVCVDLGDWEA 66 + +TGA G G + G +V R + L +L E + P+ +D+ D A Sbjct: 24 LFITGATSGFGEACARRFAEAGWSLVLTGRREERLQALAGELSAKTRVLPLTLDVRDRAA 83 Query: 67 TERALGSVGPVDL-----LVNNAAVAL-LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 A+ ++ P + L+NNA +AL P + +D + N++ ++ ++++ Sbjct: 84 MSAAVDNL-PEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNIKGLLYSTRLLLP 142 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 LIA G +IVN+ S + VY TK ++ + + +L +RV + P Sbjct: 143 RLIAHGAGASIVNLGSVAGKWPYPGSHVYGGTKAFVEQFSLNLRCDLQGTGVRVTNLEP 201 >6CGE-A nrPDB Length = 328 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 16/212 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--------ECP--GIEPVCV 59 VL+TG GIG L + ++ V T DL + R CP +E + + Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65 Query: 60 DLGDWE--ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D+ D + A R + G VD+LV NA + LL P + ++A +VN+ +++ Q Sbjct: 66 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 125 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + RG G ++ S + + VYC++K AL+ L + +A+ L P + ++ + Sbjct: 126 FLPDMKRRGS-GRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLI 184 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKF 209 V T+ + P + +L+R + F Sbjct: 185 ECGPVHTAFMEKVLGSPEE---VLDRTDIHTF 213 >4Z3K-A nrPDB Length = 275 Score = 49.3 bits (116), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 67/247 (27%), Positives = 114/247 (46%), Gaps = 37/247 (14%) Query: 7 GRRV-LVTGAGKGIGR------------GTVQALHATGARVVAVSRTQADLDSLVRECPG 53 GR V L+TGA +G GR G+V L A A+ + +A+L + E G Sbjct: 20 GRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDE--ALRQLEAELGA---ERSG 74 Query: 54 IEPVCV--DLGDWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTKEA-F 100 + V V DLG ++ LG++ + LL+NNA + + F++++ Sbjct: 75 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 134 Query: 101 DRSFEVNLRAVIQVSQIVARGL-IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + + +NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML Sbjct: 135 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 194 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPHKAKTMLNRIPLGKFAEVEHVV 216 +V+ALE +RV P + T M Q T DP K + GK + + Sbjct: 195 FQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSA 252 Query: 217 NAILFLL 223 +L LL Sbjct: 253 QKLLSLL 259 >4HWK-A nrPDB Length = 288 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 67/247 (27%), Positives = 114/247 (46%), Gaps = 37/247 (14%) Query: 7 GRRV-LVTGAGKGIGR------------GTVQALHATGARVVAVSRTQADLDSLVRECPG 53 GR V L+TGA +G GR G+V L A A+ + +A+L + E G Sbjct: 33 GRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDE--ALRQLEAELGA---ERSG 87 Query: 54 IEPVCV--DLGDWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTKEA-F 100 + V V DLG ++ LG++ + LL+NNA + + F++++ Sbjct: 88 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 147 Query: 101 DRSFEVNLRAVIQVSQIVARGL-IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + + +NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML Sbjct: 148 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 207 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPHKAKTMLNRIPLGKFAEVEHVV 216 +V+ALE +RV P + T M Q T DP K + GK + + Sbjct: 208 FQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSA 265 Query: 217 NAILFLL 223 +L LL Sbjct: 266 QKLLSLL 272 >5IZ4-A nrPDB Length = 271 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 28/194 (14%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPVC----------- 58 ++TG+ GIG T G V + D R+ +E +C Sbjct: 18 VITGSASGIGAATALRFAQAGWSVAI-----GNFDDSTRDAASTVEALCRDAGAQTLIFD 72 Query: 59 VDLGDWEATERALGSVGP----VDLLVNNAAVALLQP---FLEVTKEAFDRSFEVNLRAV 111 D+G A+ V +D L+N A + P F ++ F+R + VNL + Sbjct: 73 ADVGKDADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLIGL 132 Query: 112 IQVSQIVA---RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG 168 Q+++ R + ++VNVSS + Y ++KGA++ LT +A L Sbjct: 133 YQMTRAAVPLLRESASATRSTSVVNVSSLAGLNGTGSSIAYAASKGAVNTLTLSLARNLA 192 Query: 169 PHKIRVNAVNPTVV 182 PH IRVNA+ P +V Sbjct: 193 PH-IRVNALAPGMV 205 >1ENP-A nrPDB Length = 312 Score = 47.8 bits (112), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 84/186 (45%), Gaps = 17/186 (9%) Query: 65 EATERALGSVGPVDLLVNNAAVA--LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 EA E G +D+LV++ A + +P LE +++ + A I S L Sbjct: 118 EAAECVRQDFGSIDILVHSLANGPEVSKPLLETSRKGY--------LAAISASSYSFVSL 169 Query: 123 IARGVP-----GAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELG-PHKIRVN 175 ++ +P GA ++++ S+R + + S K AL+ T+V+A E G IRVN Sbjct: 170 LSHFLPIMNPGGASISLTYIASERIIPGYGGGMSSAKAALESDTRVLAFEAGRKQNIRVN 229 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 ++ + + +A + N P+ K + V NA FL+S + TG+T+ Sbjct: 230 TISAGPLGSRAAKAIGFIDTMIEYSYNNAPIQKTLTADEVGNAAAFLVSPLASAITGATI 289 Query: 236 PVEGGF 241 V+ G Sbjct: 290 YVDNGL 295 >4HBG-A nrPDB Length = 286 Score = 47.0 bits (110), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 61/250 (24%), Positives = 94/250 (37%), Gaps = 64/250 (25%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD-------------SLVREC------ 51 +VTGA +GIG+ Q L G + + T+ ++ S R+C Sbjct: 8 IVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQSGLSYQRQCAIAIDF 67 Query: 52 ---------------------PGIEPVCVDLGD----WEATERALGSVGPVDLLVNNAAV 86 P ++ L D W ER V+LL+N A + Sbjct: 68 KKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYY----VNLLINCAGL 123 Query: 87 ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA--RGVPG--------AIVNVSS 136 + T VN + + ++ I + ++ R P IVN+SS Sbjct: 124 TQESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISS 183 Query: 137 --QCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM-TSMGQATWSD 193 + V SVY ++K AL T+V+A E+ P IR ++P +V T M Q Sbjct: 184 ILHSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQNL--- 240 Query: 194 PHKAKTMLNR 203 P +AK ML R Sbjct: 241 PVEAKEMLER 250 >5PGZ-A nrPDB Length = 276 Score = 47.0 bits (110), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 76/180 (42%), Gaps = 11/180 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI-----EPVCV 59 L G++V+VTGA KGIGR L GA VV +R++ L +V C + + Sbjct: 16 LQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAG 75 Query: 60 DLGDWEATERALGSVGP----VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 + D E+ + G +D+L+ N + R EVN + + +S Sbjct: 76 TMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMS 135 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 A + + G+I +SS + + Y ++K ALD + EL K+ V+ Sbjct: 136 --TAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVS 193 >1E3W-A nrPDB Length = 261 Score = 46.6 bits (109), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 26/232 (11%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---IEP--VCVDLGDWE 65 ++TG G+G T + L GA V + ++ ++ ++ G P V + Sbjct: 14 VITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQA 73 Query: 66 ATERALGSVGPVDLLVNNAAVAL-LQPFLEV-----TKEAFDRSFEVNLRAVIQVSQIVA 119 A A G +D+ VN A +A+ ++ + E T E F R VNL V ++VA Sbjct: 74 ALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIRLVA 133 Query: 120 RGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 G++ + P G I+N +S + + Y ++KG + +T +A +L P IR Sbjct: 134 -GVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIR 192 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220 V + P + T + + P + L +++P LG AE H+V ++ Sbjct: 193 VVTIAPGLFATPL---LTTLPDTVRNFLASQVPFPSRLGDPAEYAHLVQMVI 241 >5WQO-A nrPDB Length = 234 Score = 45.1 bits (105), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 14/189 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRT---QADLDSLV-RECPGIEPVCVDLGDWE 65 VL+ GA +GIG G A GA+V AV+R L +L R ++ V DL + Sbjct: 9 VLIVGASRGIGLGLADAFLQRGAQVFAVARRPQGSPGLQALAERAGERLQAVTGDLNQHD 68 Query: 66 ATERALGSVGP--VDLLVNNAAV--ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 ER +G +D L+ NA + Q E+ E + F N A +++++ ++ G Sbjct: 69 CAERIGEMLGERRIDRLIVNAGIYGPQQQDVAEIDAEQTAQLFLTNAIAPLRLARALS-G 127 Query: 122 LIARGVPGAIVNVSSQCSQRAV---TNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 ++RG G + +SSQ + A+ +Y ++K AL+ L + E + ++ Sbjct: 128 RVSRG--GVVAFMSSQMASLALGLSATMPLYGASKAALNSLVRSWEGEFEELPFSLLLLH 185 Query: 179 PTVVMTSMG 187 P V T MG Sbjct: 186 PGWVRTEMG 194 >3U9L-A nrPDB Length = 324 Score = 44.7 bits (104), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 23/132 (17%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC---- 58 + ++ + +L+TGA G GR T +AL G RV A R D + R +E + Sbjct: 1 MVMSKKIILITGASSGFGRLTAEALAGAGHRVYASMR-----DIVGRNASNVEAIAGFAR 55 Query: 59 ---VDLGDWE-----------ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSF 104 VDL E A ++ +G G +D+L++NA + P T E F + Sbjct: 56 DNDVDLRTLELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELY 115 Query: 105 EVNLRAVIQVSQ 116 ++N+ + +V++ Sbjct: 116 DINVLSTQRVNR 127 >3OML-A nrPDB Length = 613 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 50/197 (25%), Positives = 84/197 (42%), Gaps = 23/197 (11%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVV---------AVSRTQADLDSLVREC- 51 +L GR +VTGAG G+GR GA+VV +Q D +V E Sbjct: 14 KLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIR 73 Query: 52 -PGIEPVCVDLGDWEAT-------ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRS 103 G E V D+ + E A+ + G VD+LVNNA + + ++ +++ ++ Sbjct: 74 KAGGEAVA----DYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLV 129 Query: 104 FEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVM 163 +V+L+ + +Q A + + G I+ SS Y + K L L + Sbjct: 130 NDVHLKGSFKCTQ-AAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTV 188 Query: 164 ALELGPHKIRVNAVNPT 180 A+E + + N + PT Sbjct: 189 AIEGARNNVLCNVIVPT 205 >5ILO-A nrPDB Length = 271 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 83/193 (43%), Gaps = 21/193 (10%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR-----ECPGIEPVCVDL 61 G+ +VTG GIG + L A GA VA+ Q +L+ V+ + + +D+ Sbjct: 15 GKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIKMDV 74 Query: 62 GDW---EAT-ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ--VS 115 + EAT E + G +D++VN A + + R+ VNL +I +S Sbjct: 75 ANKKGVEATYEEIAKTFGNIDIVVNVAGI--------FNDKDVQRTLLVNLGGIINSTLS 126 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK--IR 173 + G G G +VN+SS + VY +TK + T+ +A E + I+ Sbjct: 127 ALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIK 186 Query: 174 VNAVNPTVVMTSM 186 V P MT M Sbjct: 187 FVTVCPGATMTDM 199 >3PPI-A nrPDB Length = 281 Score = 40.4 bits (93), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 104/256 (40%), Gaps = 34/256 (13%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVV----AVSRTQADLDSLVRECPGIEPVCVDLG 62 G +V+G G+G TV+ LHA G VV A + +A D L E V ++ Sbjct: 30 GASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRA---EFVSTNVT 86 Query: 63 DWEATERALGSVGPVDLL----VNNAAVALLQPFLE-----VTKEAFDRSFEVNLRAVIQ 113 ++ A+ + + L V + + Q ++ F ++ ++ L Sbjct: 87 SEDSVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYLNGTYN 146 Query: 114 VSQIVARGLIA-----RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG 168 V+++VA + A G GA+V +S + Y + K + LT A +L Sbjct: 147 VARLVAASIAAAEPRENGERGALVLTASIAGYEGQIGQTAYAAAKAGVIGLTIAAARDLS 206 Query: 169 PHKIRVNAVNP----TVVMTSMGQATWSDPHKAKTMLNRIPLGK-FAEVEHVVNAILFLL 223 IRVN + P T +M S+G+ AK N IP K + +A FLL Sbjct: 207 SAGIRVNTIAPGTMKTPIMESVGEEAL-----AKFAAN-IPFPKRLGTPDEFADAAAFLL 260 Query: 224 SDRSGMTTGSTLPVEG 239 ++ G G + ++G Sbjct: 261 TN--GYINGEVMRLDG 274 >1SNY-A nrPDB Length = 267 Score = 40.4 bits (93), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 103/208 (49%), Gaps = 28/208 (13%) Query: 10 VLVTGAGKGIGRGTVQAL-----HATGARVVAVSRTQA-DLDSLVRECPGIEPVCVDLGD 63 +L+TG +G+G G V+AL +R QA +L+ L + I + +DL + Sbjct: 24 ILITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKELEDLAKNHSNIHILEIDLRN 83 Query: 64 WEATERALGSVGPV------DLLVNNAAVALLQPFLEV--TKEAFDRSFEVNL------- 108 ++A ++ + + V ++L NNA +A + ++E D + + N Sbjct: 84 FDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLD-TLQTNTVVPIMLA 142 Query: 109 RAVIQVSQIVARGLIAR--GV-PGAIVNVSSQC-SQRAVTNHSVYC--STKGALDMLTKV 162 +A + + + A+ ++ GV AI+N+SS S + T+ +Y ++K AL+ TK Sbjct: 143 KACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRTSKSALNAATKS 202 Query: 163 MALELGPHKIRVNAVNPTVVMTSMGQAT 190 ++++L P +I +++P V T MG ++ Sbjct: 203 LSVDLYPQRIMCVSLHPGWVKTDMGGSS 230 >3E9N-A nrPDB Length = 245 Score = 39.7 bits (91), Expect = 0.001, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 100/232 (43%), Gaps = 15/232 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + L + +VTGA G+G V+ L + V A+ R L +L E G+EP+ D+ Sbjct: 1 MSLKKKIAVVTGATGGMGIEIVKDL-SRDHIVYALGRNPEHLAALA-EIEGVEPIESDIV 58 Query: 63 DW---EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 E L ++ VD LV+ AAVA + + ++N+ ++S+ + Sbjct: 59 KEVLEEGGVDKLKNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLL 118 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 L R G ++ ++S +++Y ++K AL L E + IRV+ V+P Sbjct: 119 PAL--RAASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRKEEANNGIRVSTVSP 176 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 T M Q + I + E + + NAI F++ +G TT Sbjct: 177 GPTNTPMLQGLMDS--QGTNFRPEI----YIEPKEIANAIRFVID--AGETT 220 >4Q9N-A nrPDB Length = 298 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 82/180 (45%), Gaps = 7/180 (3%) Query: 65 EATERALGSVGPVDLLVNNAAVA--LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 E E+ G +D+LV++ A + + +P L+ +++ + + + + I S + G Sbjct: 108 EVVEQVKKHFGHIDILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFI--SLLSHFGP 165 Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELGPH-KIRVNAVNPT 180 I + ++++ S RAV + + K AL+ TKV+A E G +RVN ++ Sbjct: 166 IMN-AGASTISLTYLASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAG 224 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + G+A + PL E E V A FL+S + TG TL V+ G Sbjct: 225 PLASRAGKAIGFIERMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHG 284 >2VN8-A nrPDB Length = 375 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 5/77 (6%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G+RVL+ GA G+G +Q + A A V AV D LVR+ + + G + Sbjct: 184 GKRVLILGASGGVGTFAIQVMKAWDAHVTAV--CSQDASELVRKLGADDVIDYKSG---S 238 Query: 67 TERALGSVGPVDLLVNN 83 E L S+ P D +++N Sbjct: 239 VEEQLKSLKPFDFILDN 255 >2HRB-A nrPDB Length = 274 Score = 37.7 bits (86), Expect = 0.005, Method: Compositional matrix adjust. Identities = 54/169 (31%), Positives = 79/169 (46%), Gaps = 21/169 (12%) Query: 7 GRRV-LVTGAGKGIGRGTVQAL--HATGARVVA---VSRTQADLDSLVRECPGIEPVC-- 58 G RV LVTGA +GIG + L +G V+ V+R QA + L E G+ P Sbjct: 1 GSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQ 58 Query: 59 VDLGDWEATERAL-----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 +D+ D ++ RAL G +++LVNNAAVA F FD E+ L+ Sbjct: 59 LDIDDLQSI-RALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFF 113 Query: 114 VSQIVARGLIARGVP-GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK 161 ++ + L+ P G +VN+SS RA N S + + LT+ Sbjct: 114 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTE 162 >5TQV-A nrPDB Length = 233 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 90/204 (44%), Gaps = 12/204 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 + VL+ GA +G+GR V+ G V+A +R A L +L G +D+ E Sbjct: 10 KTVLIVGASRGLGREFVRQYQRDGWNVIATARDDASLAAL--RALGAHAHALDITQPEQI 67 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLE----VTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + L V + P E + + FD N+R +Q+ I+ L+ Sbjct: 68 AALGWKLDGERLDVAVVVSGVYGPRTEGVETIASDDFDTVMHTNVRGPMQLLPILLP-LV 126 Query: 124 --ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 ARGV + + S+ T +Y ++K AL+ + ++ +L+ H ++ ++P Sbjct: 127 EDARGVLAVVSSRMGSISEATGTTGWLYRASKAALNDVLRIASLQT-RHAACIS-LHPGW 184 Query: 182 VMTSMGQATWS-DPHKAKTMLNRI 204 V T MG A + DP + T + R+ Sbjct: 185 VRTDMGGAQAALDPATSVTGMRRV 208 >5K1S-A nrPDB Length = 362 Score = 36.6 bits (83), Expect = 0.010, Method: Compositional matrix adjust. Identities = 19/42 (45%), Positives = 28/42 (66%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 AG VL+TGA G+G +VQ GARV+AV+ ++A + +L Sbjct: 183 AGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQAL 224 >1N5D-A nrPDB Length = 288 Score = 35.8 bits (81), Expect = 0.015, Method: Compositional matrix adjust. Identities = 53/167 (31%), Positives = 75/167 (44%), Gaps = 20/167 (11%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLVRECPGIEPVC--VD 60 R LVTGA KGIG V+ L A V V+R QA + L E G+ P +D Sbjct: 5 RVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAE--GLSPRFHQLD 62 Query: 61 LGDWEATERAL-----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 + D ++ RAL G +D+LVNNAA+A F F E+ ++ + Sbjct: 63 IIDLQSI-RALCDFLRKEYGGLDVLVNNAAIA----FQLDNPTPFHIQAELTMKTNFMGT 117 Query: 116 QIVARGLIARGVP-GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK 161 + V L+ P G +VNVSS RA+ S K + +T+ Sbjct: 118 RNVCTELLPLIKPQGRVVNVSSTEGVRALNECSPELQQKFKSETITE 164 >2PTG-A nrPDB Length = 319 Score = 35.8 bits (81), Expect = 0.017, Method: Compositional matrix adjust. Identities = 50/195 (25%), Positives = 89/195 (45%), Gaps = 25/195 (12%) Query: 65 EATERALGSVGPVDLLVNNAAVA--LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 E E VG +D+LV++ A + +P L+ +++ + A + S L Sbjct: 122 EVAEAVRADVGQIDILVHSLANGPEVTKPLLQTSRKGY--------LAAVSSSSYSFVSL 173 Query: 123 IARGVP-----GAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELGPHK-IRVN 175 + +P G+ + +S S++ + + S K AL+ + +A E G + +RVN Sbjct: 174 LQHFLPLMKEGGSALALSYIASEKVIPGYGGGMSSAKAALESDCRTLAFEAGRARAVRVN 233 Query: 176 AVN----PTVVMTSMGQA---TWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 ++ + +++G+A T+ D + N PL K E + V A LFLLS + Sbjct: 234 CISAGPLKSRAASAIGKAGDKTFIDLAIDYSEAN-APLQKELESDDVGRAALFLLSPLAR 292 Query: 229 MTTGSTLPVEGGFWA 243 TG+TL V+ G A Sbjct: 293 AVTGATLYVDNGLHA 307 >3BHI-A nrPDB Length = 276 Score = 35.0 bits (79), Expect = 0.033, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 76/164 (46%), Gaps = 20/164 (12%) Query: 11 LVTGAGKGIGRGTVQALHA--TGARVVA---VSRTQADLDSLVRECPGIEPVC--VDLGD 63 LVTG KGIG V+ L +G V+ V+R QA + L E G+ P +D+ D Sbjct: 8 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAE--GLSPRFHQLDIDD 65 Query: 64 WEATERAL-----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 ++ RAL G +D+LVNNA +A F F EV ++ ++ V Sbjct: 66 LQSI-RALRDFLRKEYGGLDVLVNNAGIA----FKVADPTPFHIQAEVTMKTNFFGTRDV 120 Query: 119 ARGLIARGVP-GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK 161 L+ P G +VNVSS S RA+ + S K + +T+ Sbjct: 121 CTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITE 164 >4OMU-A nrPDB Length = 283 Score = 32.3 bits (72), Expect = 0.19, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 10/85 (11%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGAR-VVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 LAG+R+L+ GAG + RG ++ + A + +V +RT + L RE + PV Sbjct: 117 LAGKRILILGAGGAV-RGVLEPILAHKPQSLVIANRTVEKAEQLAREFDELGPVVASGFA 175 Query: 64 WEATERALGSVGPVDLLVNNAAVAL 88 W PVD+++N + +L Sbjct: 176 WLQE--------PVDVIINATSASL 192 >4J6F-A nrPDB Length = 382 Score = 32.3 bits (72), Expect = 0.21, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 41/102 (40%), Gaps = 22/102 (21%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 AG VLVTGA G+G +Q A GA +AV+ PG E +D+G Sbjct: 206 AGETVLVTGASGGVGSAIIQLARARGAVPIAVA------------GPGKEAAMLDIGAQA 253 Query: 66 ATERALGSVG----------PVDLLVNNAAVALLQPFLEVTK 97 R G + P+D++ + L L++ + Sbjct: 254 VVTRGQGDLAEAVEAASGGRPIDVVADLVGGPLFNDLLKILR 295 >5JXW-A nrPDB Length = 498 Score = 32.0 bits (71), Expect = 0.23, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 16/55 (29%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC 58 LAG++++V G G+ +G+G Q L GARV+ I+P+C Sbjct: 268 MLAGKKIVVLGYGE-VGKGCAQGLSGVGARVIVTE---------------IDPIC 306 >4N7R-A nrPDB Length = 472 Score = 32.0 bits (71), Expect = 0.24, Method: Compositional matrix adjust. Identities = 19/48 (39%), Positives = 31/48 (64%), Gaps = 2/48 (4%) Query: 9 RVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVRECPGIE 55 R+ V GAGK +G+ ++ L A G +VV V+R++ + ++ E PGIE Sbjct: 209 RMCVIGAGK-MGKLVIKHLMAKGCTKVVVVNRSEERVSAIREEMPGIE 255 >5LCX-A nrPDB Length = 316 Score = 31.6 bits (70), Expect = 0.32, Method: Compositional matrix adjust. Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 14/116 (12%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD----LDSLVRECPGIEPVCV---- 59 R LVTGA KGIG + L G V+ SR + L++E E V Sbjct: 8 RYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQL 67 Query: 60 ---DLGDWEATERALGS-VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 DL A + S G +D+LVNNA V+ ++ +V+ F+ E + +A+ Sbjct: 68 DVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVS--VFNEYIEADFKAL 121 >1FZE-A nrPDB Length = 87 Score = 31.2 bits (69), Expect = 0.47, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 32 ARVVAVSRTQADLDSLVRECPGIEPVC-------VDLGDWEATERALGSVGPVDLL 80 A++V + R + D+D +R C G C VDL D+E ++ L V DLL Sbjct: 32 AQLVDMKRLEVDIDIKIRSCRG---SCSRALAREVDLKDYEDQQKQLEQVIAKDLL 84 >4OYR-A nrPDB Length = 289 Score = 30.8 bits (68), Expect = 0.54, Method: Compositional matrix adjust. Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 12/123 (9%) Query: 129 GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN--AVNP--TVVMT 184 G+IV + S RA+ ++ K AL+ + + +A E G + +R N A P T+ M+ Sbjct: 162 GSIVGMDFDPS-RAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMS 220 Query: 185 SMGQATWSDPHKAKTML------NRIPLG-KFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 ++ + A+ L R P+G + V + LLSD TTG + Sbjct: 221 AIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYA 280 Query: 238 EGG 240 +GG Sbjct: 281 DGG 283 >3O26-A nrPDB Length = 311 Score = 30.0 bits (66), Expect = 0.91, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 68/192 (35%), Gaps = 47/192 (24%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV-----DLG 62 R +VTG KGIG + L + G VV R V + V D+ Sbjct: 13 RCAVVTGGNKGIGFEICKQLSSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQLDVT 72 Query: 63 DWEATERALGS-----VGPVDLLVNNAAVALL---------------------------- 89 D AT +L G +D+LVNNA VA Sbjct: 73 DPIATMSSLADFIKTHFGKLDILVNNAGVAGFSVDADRFKAMISDIGEDSEELVKIYEKP 132 Query: 90 --QPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHS 147 Q + T E + ++N V V++++ L P IVNVSS T Sbjct: 133 EAQELMSETYELAEECLKINYNGVKSVTEVLIPLLQLSDSP-RIVNVSSS------TGSL 185 Query: 148 VYCSTKGALDML 159 Y S + AL++L Sbjct: 186 KYVSNETALEIL 197 >2NTV-A nrPDB Length = 268 Score = 30.0 bits (66), Expect = 1.1, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 57/123 (46%), Gaps = 12/123 (9%) Query: 129 GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN--AVNP--TVVMT 184 G+IV + + RA+ ++ K AL+ + + +A E G + +R N A P T+ M+ Sbjct: 141 GSIVGMDFDPT-RAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMS 199 Query: 185 SMGQATWSDPHKAKTML------NRIPLG-KFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 ++ + + A+ L R P+G + V + LLS+ TTGS + Sbjct: 200 AIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAKTVCALLSEWLPATTGSIIYA 259 Query: 238 EGG 240 +GG Sbjct: 260 DGG 262 >3H32-A nrPDB Length = 197 Score = 30.0 bits (66), Expect = 1.1, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 32 ARVVAVSRTQADLDSLVRECPGIEPVC-------VDLGDWEATERALGSVGPVDLL 80 A++V + R + D+D +R C G C VDL D+E ++ L V DLL Sbjct: 142 AQLVDMKRLEVDIDIKIRSCRG---SCSRALAREVDLKDYEDQQKQLEQVIAKDLL 194 >6EHL-A nrPDB Length = 739 Score = 29.6 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 11/79 (13%) Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-----------P 205 + L K + + G H + + N V+ S+ QA +S KT+L+ I P Sbjct: 207 NFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHP 266 Query: 206 LGKFAEVEHVVNAILFLLS 224 L + A+V++ VN+ LS Sbjct: 267 LARTAKVKNEVNSFKAALS 285 >6APH-A nrPDB Length = 445 Score = 29.6 bits (65), Expect = 1.2, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 21/87 (24%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ LAG+RV+V G G +G+GT + G+ +V V+ I+P+C Sbjct: 221 DVMLAGKRVVVCGFGD-VGKGTAASFRGAGS-IVTVTE--------------IDPICALQ 264 Query: 62 GDWEATERALGSVGPVDLLVNNAAVAL 88 E E V +D +V+NA + + Sbjct: 265 AAMEGYE-----VKQLDTVVDNADIII 286 >1O89-A nrPDB Length = 345 Score = 29.3 bits (64), Expect = 1.5, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 23/39 (58%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 ++VTGA G+G V LH G +VVAVS ++ + L Sbjct: 170 EIVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYL 208 >3F4B-A nrPDB Length = 323 Score = 29.3 bits (64), Expect = 1.8, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 56/136 (41%), Gaps = 24/136 (17%) Query: 129 GAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELG-PHKIRVNAVNPTVVMTSM 186 G++V+++ Q SQ+ V + S K AL+ T+V+A LG + IR+N ++ + + Sbjct: 172 GSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISAGPLKSRA 231 Query: 187 GQA-----------TWSDPHKAKTMLNRI-----------PLGKFAEVEHVVNAILFLLS 224 A S K + I PL K V + FLLS Sbjct: 232 ATAINKFNNNQKNNMNSSGETDKQNYSFIDYAIDYSEKYAPLKKKLLSTDVGSVASFLLS 291 Query: 225 DRSGMTTGSTLPVEGG 240 S TG T+ V+ G Sbjct: 292 KESSAVTGQTIYVDNG 307 >3NJ4-A nrPDB Length = 435 Score = 28.9 bits (63), Expect = 1.9, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%), Gaps = 1/34 (2%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVV 35 ++ +AG+ +V G G +G+G QAL GARV+ Sbjct: 211 DVMIAGKVAVVAGYGD-VGKGCAQALRGFGARVI 243 >5L51-A nrPDB Length = 324 Score = 28.9 bits (63), Expect = 1.9, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 25/98 (25%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD----LDSLVRECPGIEPVCVDLGD 63 R +VTGA KGIG + L + G V+ SR + + L++E + + GD Sbjct: 16 RYAVVTGANKGIGFEICKQLASKGITVILASRDEKRGIEARERLIKE------LGSEFGD 69 Query: 64 WEATER----------AL-----GSVGPVDLLVNNAAV 86 + +++ AL G +D+LVNNA + Sbjct: 70 YVVSQQLDVADPASVAALVDFIKTKFGSLDILVNNAGL 107 >2ZJ1-A nrPDB Length = 495 Score = 28.9 bits (63), Expect = 1.9, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 13/90 (14%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-LDSLVRECPGIEPVCVD 60 + + G++VL+ G G +G+G +A+ GAR VS T+ D +++L G + V V Sbjct: 270 DALIGGKKVLICGYGD-VGKGCAEAMKGQGAR---VSVTEIDPINALQAMMEGFDVVTV- 324 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQ 90 E A+G V N + +L+ Sbjct: 325 -------EEAIGDADIVVTATGNKDIIMLE 347 >4ZTI-A nrPDB Length = 381 Score = 28.9 bits (63), Expect = 2.1, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 11/79 (13%) Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-----------P 205 + L K + + G H + + N V+ S+ QA +S KT+L+ I P Sbjct: 221 NFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHP 280 Query: 206 LGKFAEVEHVVNAILFLLS 224 L + A+V++ VN+ LS Sbjct: 281 LARTAKVKNEVNSFKAALS 299 >2HK7-A nrPDB Length = 269 Score = 28.9 bits (63), Expect = 2.2, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 1/45 (2%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP 52 + +LV GAG G R + AL GA+V +RT+ L ++ P Sbjct: 124 KSILVLGAG-GASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFP 167 >4Z9P-A nrPDB Length = 317 Score = 28.9 bits (63), Expect = 2.3, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 37/80 (46%), Gaps = 11/80 (13%) Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-----------P 205 + L K + + G H + + N V+ S+ QA +S KT+L+ I P Sbjct: 173 NFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHP 232 Query: 206 LGKFAEVEHVVNAILFLLSD 225 L + A+V++ VN+ LS Sbjct: 233 LARTAKVKNEVNSFKAALSS 252 >3AOE-A nrPDB Length = 424 Score = 28.5 bits (62), Expect = 2.7, Method: Compositional matrix adjust. Identities = 21/54 (38%), Positives = 26/54 (48%), Gaps = 5/54 (9%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP 56 L + G RV + G G +G +A H GARVVAV D V GI+P Sbjct: 215 LQVEGARVAIQGFGN-VGNAAARAFHDHGARVVAVQ----DHTGTVYNEAGIDP 263 >5Z9W-A nrPDB Length = 388 Score = 28.5 bits (62), Expect = 3.0, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 11/74 (14%) Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-----------P 205 + L K + + G H + + N V+ S+ QA +S KT+L+ I P Sbjct: 189 NFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHP 248 Query: 206 LGKFAEVEHVVNAI 219 L + A+V++ VN+ Sbjct: 249 LARTAKVKNEVNSF 262 >3G1U-A nrPDB Length = 437 Score = 28.5 bits (62), Expect = 3.1, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 21/34 (61%), Gaps = 1/34 (2%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVV 35 ++ +AG+ V G G +G+G AL A GARVV Sbjct: 207 DVMIAGKTCCVCGYGD-VGKGCAAALRAFGARVV 239 >6C54-A nrPDB Length = 433 Score = 28.1 bits (61), Expect = 3.5, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 11/79 (13%) Query: 157 DMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-----------P 205 + L K + + G H + + N V+ S+ QA +S KT+L+ I P Sbjct: 183 NFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHP 242 Query: 206 LGKFAEVEHVVNAILFLLS 224 L + A+V++ VN+ LS Sbjct: 243 LARTAKVKNEVNSFKAALS 261 >3GHG-A nrPDB Length = 562 Score = 28.1 bits (61), Expect = 3.6, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 32 ARVVAVSRTQADLDSLVRECPGIEPVC-------VDLGDWEATERALGSVGPVDLL 80 A++V + R + D+D +R C G C VDL D+E ++ L V DLL Sbjct: 142 AQLVDMKRLEVDIDIKIRSCRG---SCSRALAREVDLKDYEDQQKQLEQVIAKDLL 194 >3RFT-A nrPDB Length = 267 Score = 27.7 bits (60), Expect = 5.3, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 45/93 (48%), Gaps = 8/93 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 +A +R+LVTGA +GR + L A A ++ + ADL L P E V DL D Sbjct: 1 MAMKRLLVTGAAGQLGRVMRERL-APMAEILRL----ADLSPLDPAGPNEECVQCDLADA 55 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTK 97 A V D +V+ +++ +PF ++ + Sbjct: 56 NAVN---AMVAGCDGIVHLGGISVEKPFEQILQ 85 >2EGG-A nrPDB Length = 297 Score = 27.3 bits (59), Expect = 5.5, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 12/118 (10%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 M + L G+R+LV GAG G L R+ +RT + LVRE Sbjct: 135 MNITLDGKRILVIGAGGGARGIYFSLLSTAAERIDMANRTVEKAERLVREGDERRSAYFS 194 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 L + E + D+++N +V + P +EV + +R LR + VS I+ Sbjct: 195 LAEAET------RLAEYDIIINTTSVG-MHPRVEVQPLSLER-----LRPGVIVSDII 240 >3N58-A nrPDB Length = 464 Score = 27.3 bits (59), Expect = 5.8, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 22/33 (66%), Gaps = 1/33 (3%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARV 34 ++ +AG+ +V G G +G+G+ Q+L GARV Sbjct: 242 DVMMAGKVAVVCGYGD-VGKGSAQSLAGAGARV 273 >6GBN-A nrPDB Length = 438 Score = 27.3 bits (59), Expect = 6.6, Method: Compositional matrix adjust. Identities = 15/57 (26%), Positives = 27/57 (47%), Gaps = 16/57 (28%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC 58 ++ +AG+ +V G G +G+G+ +L GARV+ I+P+C Sbjct: 214 DVMMAGKVAVVAGYGD-VGKGSAASLRGAGARVIVTE---------------IDPIC 254 >4F35-D nrPDB Length = 449 Score = 26.9 bits (58), Expect = 7.3, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 29/70 (41%), Gaps = 1/70 (1%) Query: 82 NNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQR 141 N A+ ALL P EAF S V L +I V+ A L P AIV S Q Sbjct: 365 NTASAALLIPVFATVAEAFGMS-PVLLSVLIAVAASCAFMLPVATPPNAIVFASGHIKQS 423 Query: 142 AVTNHSVYCS 151 + +Y + Sbjct: 424 EMMRVGLYLN 433 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3D3W-A nrPDB 310 2e-85 2PNF-A nrPDB 282 9e-77 1CYD-A nrPDB 275 1e-74 2C07-A nrPDB 265 1e-71 3RSH-A nrPDB 263 4e-71 4JRO-A nrPDB 263 4e-71 3F9I-A nrPDB 260 5e-70 2UVD-A nrPDB 259 9e-70 3EMK-A nrPDB 258 2e-69 3OSU-A nrPDB 256 5e-69 5ITV-A nrPDB 255 1e-68 5CDY-A nrPDB 255 2e-68 3LYL-A nrPDB 255 2e-68 3FTP-A nrPDB 254 2e-68 2HQ1-A nrPDB 254 3e-68 1Q7C-A nrPDB 254 3e-68 4M8S-A nrPDB 249 8e-67 3WOH-A nrPDB 247 4e-66 1AE1-A nrPDB 246 7e-66 3O4R-A nrPDB 244 3e-65 3GRP-A nrPDB 243 7e-65 2AE2-A nrPDB 241 2e-64 4Z9Y-A nrPDB 241 2e-64 1GEE-A nrPDB 241 3e-64 2NM0-A nrPDB 240 4e-64 4BO1-A nrPDB 240 4e-64 4KMS-A nrPDB 239 7e-64 3AUT-A nrPDB 239 7e-64 2ZAT-A nrPDB 238 1e-63 4NBT-A nrPDB 238 1e-63 6NRP-A nrPDB 238 2e-63 4K6F-A nrPDB 237 3e-63 3EZL-A nrPDB 237 4e-63 2PH3-A nrPDB 236 5e-63 4DMM-A nrPDB 235 2e-62 3OEC-A nrPDB 234 2e-62 4HP8-A nrPDB 234 3e-62 4IIN-A nrPDB 233 4e-62 5OVL-A nrPDB 233 5e-62 4CQL-A nrPDB 233 6e-62 5U9P-A nrPDB 232 1e-61 5VT6-A nrPDB 231 2e-61 1O5I-A nrPDB 230 4e-61 4RZH-A nrPDB 230 7e-61 1GEG-A nrPDB 229 1e-60 5OVJ-A nrPDB 228 2e-60 3VZS-A nrPDB 226 6e-60 2CDH-G nrPDB 226 7e-60 6CI9-A nrPDB 225 1e-59 2Q2Q-A nrPDB 225 2e-59 1UZM-A nrPDB 225 2e-59 4NBV-A nrPDB 223 5e-59 2EW8-A nrPDB 223 6e-59 5T5Q-A nrPDB 222 1e-58 1YXM-A nrPDB 221 1e-58 4AVY-A nrPDB 221 2e-58 5OJG-A nrPDB 221 2e-58 4CQM-B nrPDB 220 3e-58 3UVE-A nrPDB 220 3e-58 4IIV-A nrPDB 220 4e-58 3UF0-A nrPDB 220 4e-58 4RZI-B nrPDB 220 6e-58 1K2W-A nrPDB 219 7e-58 3WTC-A nrPDB 219 9e-58 1NFF-A nrPDB 219 1e-57 5YSS-A nrPDB 218 1e-57 3W8F-A nrPDB 217 3e-57 4IS3-A nrPDB 217 3e-57 3V2G-A nrPDB 217 4e-57 1X1T-A nrPDB 216 6e-57 3V2H-A nrPDB 216 7e-57 3WYE-A nrPDB 215 1e-56 3T7C-A nrPDB 215 1e-56 4DBZ-A nrPDB 211 2e-55 4E6P-A nrPDB 211 2e-55 2AG5-A nrPDB 211 2e-55 1AHH-A nrPDB 210 4e-55 2CFC-A nrPDB 210 4e-55 2B4Q-A nrPDB 209 9e-55 5B1Y-A nrPDB 209 1e-54 3RWB-A nrPDB 209 1e-54 4EGF-A nrPDB 208 2e-54 5EJ2-A nrPDB 208 3e-54 3R3S-A nrPDB 207 3e-54 2P91-A nrPDB 207 4e-54 3OIC-A nrPDB 205 1e-53 4FC7-A nrPDB 205 1e-53 2FWM-X nrPDB 204 2e-53 4MOW-A nrPDB 204 2e-53 2HSD-A nrPDB 202 1e-52 3U5T-A nrPDB 201 2e-52 3A28-C nrPDB 201 3e-52 5TF4-A nrPDB 200 4e-52 3OIG-A nrPDB 199 1e-51 3UN1-A nrPDB 198 1e-51 1DOH-A nrPDB 198 2e-51 2YW9-A nrPDB 195 1e-50 3GRK-A nrPDB 195 1e-50 5YCX-A nrPDB 195 2e-50 1H5Q-A nrPDB 194 3e-50 3U4C-A nrPDB 193 4e-50 4ZJU-A nrPDB 193 8e-50 4M89-A nrPDB 193 9e-50 4GKB-A nrPDB 192 1e-49 5KOI-A nrPDB 192 1e-49 4CR6-A nrPDB 191 2e-49 3K2E-A nrPDB 191 3e-49 1HXH-A nrPDB 190 4e-49 3GDF-A nrPDB 189 6e-49 5CFZ-A nrPDB 189 7e-49 5JS6-A nrPDB 189 7e-49 4RGB-A nrPDB 189 7e-49 4ALL-A nrPDB 188 1e-48 4TRR-A nrPDB 188 2e-48 4JQC-A nrPDB 188 3e-48 5I9N-A nrPDB 186 6e-48 4NK4-A nrPDB 183 9e-47 3V8B-A nrPDB 182 1e-46 3ZV3-A nrPDB 181 2e-46 2X9N-A nrPDB 180 5e-46 5JY1-A nrPDB 179 9e-46 4J3F-A nrPDB 179 1e-45 5O3Z-A nrPDB 179 1e-45 1BDB-A nrPDB 178 2e-45 1W73-A nrPDB 178 3e-45 2GDZ-A nrPDB 174 2e-44 2QHX-A nrPDB 172 1e-43 2BFA-A nrPDB 171 2e-43 1P33-A nrPDB 171 2e-43 2PD3-A nrPDB 167 4e-42 2BGM-A nrPDB 165 1e-41 3PXX-A nrPDB 164 3e-41 3OML-A nrPDB 164 3e-41 2O23-A nrPDB 161 2e-40 4DA9-A nrPDB 161 2e-40 1E3W-A nrPDB 159 1e-39 2NWQ-A nrPDB 156 6e-39 3RKU-A nrPDB 156 6e-39 3E9N-A nrPDB 152 1e-37 5IZ4-A nrPDB 149 1e-36 1A27-A nrPDB 149 1e-36 3PPI-A nrPDB 148 2e-36 6CGE-A nrPDB 148 2e-36 4Q9N-A nrPDB 146 6e-36 4DRY-A nrPDB 146 7e-36 2DKN-A nrPDB 146 1e-35 1ENP-A nrPDB 144 3e-35 4HBG-A nrPDB 141 3e-34 3DWF-A nrPDB 138 2e-33 5PGZ-A nrPDB 137 5e-33 5ILO-A nrPDB 136 6e-33 1FJH-A nrPDB 134 4e-32 3UCF-A nrPDB 132 2e-31 3KZV-A nrPDB 131 4e-31 1SNY-A nrPDB 118 2e-27 4Z3K-A nrPDB 117 5e-27 4HWK-A nrPDB 117 6e-27 1OAA-A nrPDB 109 1e-24 5WQO-A nrPDB 104 4e-23 3U9L-A nrPDB 102 2e-22 Sequences not found previously or not previously below threshold: 4NR0-A nrPDB 183 9e-47 2O2S-A nrPDB 140 4e-34 2PTG-A nrPDB 125 2e-29 2HRB-A nrPDB 114 3e-26 3F4B-A nrPDB 112 1e-25 2NTV-A nrPDB 108 2e-24 4OYR-A nrPDB 108 2e-24 2O2Y-A nrPDB 102 1e-22 3BHI-A nrPDB 102 2e-22 1N5D-A nrPDB 102 2e-22 5L51-A nrPDB 100 4e-22 1B15-A nrPDB 98 3e-21 3O26-A nrPDB 91 4e-19 1MG5-A nrPDB 89 1e-18 5TQV-A nrPDB 89 1e-18 5LCX-A nrPDB 75 2e-14 2PK3-A nrPDB 66 1e-11 3SLK-A nrPDB 64 4e-11 3RFT-A nrPDB 61 4e-10 4LIS-A nrPDB 61 4e-10 2Q1W-A nrPDB 58 3e-09 3ORF-A nrPDB 57 5e-09 6BWL-A nrPDB 57 5e-09 1OOE-A nrPDB 54 5e-08 2PZM-A nrPDB 54 5e-08 1UDA-A nrPDB 52 1e-07 1DIR-A nrPDB 52 2e-07 2GN9-A nrPDB 51 5e-07 4G5H-A nrPDB 50 7e-07 1Z45-A nrPDB 50 9e-07 1WVG-A nrPDB 49 1e-06 4PVC-A nrPDB 49 3e-06 1VL0-A nrPDB 47 5e-06 1RKX-A nrPDB 47 9e-06 4J2O-A nrPDB 46 2e-05 1I3M-A nrPDB 46 2e-05 4KTT-E nrPDB 44 5e-05 1GY8-A nrPDB 44 8e-05 3SC6-A nrPDB 43 1e-04 2NNL-D nrPDB 43 1e-04 5K1S-A nrPDB 42 2e-04 5B6K-A nrPDB 42 2e-04 1ZZE-A nrPDB 42 3e-04 6GCS-E nrPDB 42 3e-04 2Z95-A nrPDB 42 3e-04 3ENK-A nrPDB 41 5e-04 3NJ4-A nrPDB 41 5e-04 5F5N-A nrPDB 41 6e-04 5N2I-A nrPDB 41 7e-04 6ACF-A nrPDB 41 7e-04 4KDR-A nrPDB 40 0.001 4KDC-A nrPDB 40 0.001 3SXP-A nrPDB 40 0.001 2C20-A nrPDB 39 0.001 2HUN-A nrPDB 39 0.002 1BXK-A nrPDB 39 0.002 2EXX-A nrPDB 39 0.002 3HFS-A nrPDB 39 0.002 4J6F-A nrPDB 39 0.002 3OND-A nrPDB 39 0.003 2VN8-A nrPDB 38 0.003 1KEU-A nrPDB 38 0.003 1R66-A nrPDB 38 0.005 4G65-A nrPDB 37 0.005 1OC2-A nrPDB 37 0.005 5INT-A nrPDB 37 0.006 6DEB-A nrPDB 37 0.007 3VPX-A nrPDB 37 0.008 1E3J-A nrPDB 37 0.009 3N58-A nrPDB 36 0.012 4K28-A nrPDB 36 0.013 3PVZ-A nrPDB 36 0.013 4EJ6-A nrPDB 36 0.014 2C54-A nrPDB 36 0.017 2GAS-A nrPDB 36 0.017 2HK7-A nrPDB 36 0.021 4WPG-A nrPDB 36 0.022 2GGS-A nrPDB 35 0.030 1LU9-A nrPDB 35 0.030 5ENV-A nrPDB 35 0.032 1O89-A nrPDB 35 0.036 3DFZ-A nrPDB 35 0.041 4EJ0-A nrPDB 34 0.042 1YB5-A nrPDB 34 0.054 1EQ2-A nrPDB 34 0.055 4BKP-A nrPDB 34 0.070 2BKA-A nrPDB 34 0.071 4N18-A nrPDB 34 0.074 3LK7-A nrPDB 34 0.075 4KUG-A nrPDB 34 0.076 2X86-A nrPDB 34 0.080 6GBN-A nrPDB 34 0.080 3X2F-A nrPDB 34 0.084 5UOG-A nrPDB 34 0.087 5JXW-A nrPDB 34 0.089 6C55-A nrPDB 33 0.10 6APH-A nrPDB 33 0.11 6APE-A nrPDB 33 0.11 3DMF-A nrPDB 33 0.11 6G2J-P nrPDB 33 0.11 3WMX-A nrPDB 33 0.14 4EUF-A nrPDB 33 0.14 2QYS-A nrPDB 33 0.15 4J90-A nrPDB 32 0.16 6C6P-A nrPDB 32 0.17 7REQ-A nrPDB 32 0.17 3MOG-A nrPDB 32 0.19 4WOK-A nrPDB 32 0.21 6ACQ-A nrPDB 32 0.24 5YBH-A nrPDB 32 0.27 4B4V-A nrPDB 32 0.28 1DB3-A nrPDB 32 0.30 2EER-A nrPDB 32 0.30 5BUT-A nrPDB 32 0.31 2VWV-A nrPDB 32 0.33 2HMT-A nrPDB 32 0.33 3HDH-A nrPDB 32 0.34 3F6S-A nrPDB 32 0.35 3PEF-A nrPDB 31 0.36 3IP1-A nrPDB 31 0.37 2Q4B-A nrPDB 31 0.38 1RPN-A nrPDB 31 0.38 3H9U-A nrPDB 31 0.38 1F14-A nrPDB 31 0.41 6CU3-A nrPDB 31 0.42 1XDW-A nrPDB 31 0.44 4B4O-A nrPDB 31 0.46 5M65-A nrPDB 31 0.50 4D3S-A nrPDB 31 0.52 2OWO-A nrPDB 31 0.53 4G2N-A nrPDB 31 0.56 5GXF-A nrPDB 30 0.63 4A5O-A nrPDB 30 0.64 4DGK-A nrPDB 30 0.65 3BIC-A nrPDB 30 0.67 2ZJ1-A nrPDB 30 0.67 6F3O-A nrPDB 30 0.68 6BI4-A nrPDB 30 0.68 5YWN-A nrPDB 30 0.69 1QYD-A nrPDB 30 0.73 1C0L-A nrPDB 30 0.77 4OMU-A nrPDB 30 0.80 1JAY-A nrPDB 30 0.84 1EEP-A nrPDB 30 0.84 4FQ8-A nrPDB 30 0.90 1ZCJ-A nrPDB 30 0.92 2DFV-A nrPDB 30 0.93 6BII-A nrPDB 30 1.0 5KIA-A nrPDB 30 1.0 1X74-A nrPDB 30 1.0 4AZW-A nrPDB 30 1.1 4AZV-A nrPDB 30 1.1 5UZH-A nrPDB 30 1.1 2ZSK-A nrPDB 30 1.1 5U9C-A nrPDB 30 1.1 2R5U-A nrPDB 30 1.2 4WKG-A nrPDB 30 1.2 3ZWA-A nrPDB 30 1.2 2RIR-A nrPDB 30 1.2 2D0I-A nrPDB 29 1.4 5GUP-L nrPDB 29 1.4 3H0K-A nrPDB 29 1.4 1MLD-A nrPDB 29 1.5 3D64-A nrPDB 29 1.6 1XRS-A nrPDB 29 1.6 3JTM-A nrPDB 29 1.8 4OQY-A nrPDB 29 1.9 4Y4M-A nrPDB 29 1.9 4MIT-A nrPDB 29 2.0 5TC4-A nrPDB 29 2.2 4WEQ-A nrPDB 29 2.2 5MH6-A nrPDB 29 2.3 3G1U-A nrPDB 29 2.3 4GBJ-A nrPDB 29 2.3 4WLE-A nrPDB 29 2.3 5I1W-A nrPDB 29 2.4 1QYC-A nrPDB 29 2.4 1IM2-A nrPDB 29 2.5 1I84-U nrPDB 29 2.6 1YXY-A nrPDB 29 2.6 2YQ5-A nrPDB 29 2.7 5ZKP-A nrPDB 29 2.7 6BMQ-A nrPDB 29 2.8 4UUP-A nrPDB 29 2.9 5AOV-A nrPDB 28 3.0 4OQZ-A nrPDB 28 3.1 3FBG-A nrPDB 28 3.3 1Z82-A nrPDB 28 3.3 1HE4-A nrPDB 28 3.3 4FSH-A nrPDB 28 3.3 3R9I-A nrPDB 28 3.5 1IE3-A nrPDB 28 3.5 4UUM-A nrPDB 28 3.6 1V71-A nrPDB 28 3.8 1OFI-A nrPDB 28 3.9 4TSK-A nrPDB 28 4.4 3Q7E-A nrPDB 28 4.5 2Y0D-A nrPDB 28 4.9 1DOD-A nrPDB 28 5.1 4U4E-A nrPDB 27 5.3 5NUE-A nrPDB 27 5.4 4DLL-A nrPDB 27 5.5 3UOG-A nrPDB 27 5.7 4E0B-A nrPDB 27 5.7 5VVW-A nrPDB 27 6.1 4XRR-A nrPDB 27 6.1 4OM8-A nrPDB 27 6.3 3RI6-A nrPDB 27 6.5 2DQ4-A nrPDB 27 6.5 5LV5-A nrPDB 27 6.6 5A9T-A nrPDB 27 6.7 1UUF-A nrPDB 27 6.8 2UYY-A nrPDB 27 6.9 4EEZ-A nrPDB 27 7.0 4MLQ-A nrPDB 27 7.1 3DQQ-A nrPDB 27 7.1 4A26-A nrPDB 27 7.2 6IH4-A nrPDB 27 7.3 5XW3-A nrPDB 27 7.5 2OHJ-A nrPDB 27 7.5 6DKH-A nrPDB 27 7.6 5WYK-3B nrPDB 27 7.6 5OCM-A nrPDB 27 7.6 4PZE-A nrPDB 27 7.8 3PII-A nrPDB 27 8.1 5A3V-A nrPDB 27 8.4 3CCF-A nrPDB 27 8.4 1RK2-A nrPDB 27 8.4 2WEK-A nrPDB 27 8.5 4Y4N-A nrPDB 27 8.6 6AZ1-E nrPDB 27 8.9 2X3N-A nrPDB 27 9.1 3KAQ-A nrPDB 27 9.4 1GG0-A nrPDB 27 9.4 5UI4-A nrPDB 27 9.7 >3D3W-A nrPDB Length = 244 Score = 310 bits (796), Expect = 2e-85, Method: Composition-based stats. Identities = 244/244 (100%), Positives = 244/244 (100%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD Sbjct: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR Sbjct: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT Sbjct: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG Sbjct: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 Query: 241 FWAC 244 FWAC Sbjct: 241 FWAC 244 >2PNF-A nrPDB Length = 248 Score = 282 bits (722), Expect = 9e-77, Method: Composition-based stats. Identities = 76/251 (30%), Positives = 116/251 (46%), Gaps = 12/251 (4%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IE 55 ME+ L G+ LVTG+ +GIGR + L + G+ V+ + ++ E Sbjct: 1 MEIKLQGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAH 60 Query: 56 PVCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 V ++L E+ +A V +D+LVNNA + + FL ++ ++ +VNL Sbjct: 61 GVEMNLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGT 120 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 V+Q R +I + G IVN+SS Y +TK L TK +A EL P Sbjct: 121 FLVTQNSLRKMIKQRW-GRIVNISSVVGFTGNVGQVNYSTTKAGLIGFTKSLAKELAPRN 179 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 + VNAV P + T M + +IPLG+F E V N +LFL S+ + T Sbjct: 180 VLVNAVAPGFIETDMTAVL--SEEIKQKYKEQIPLGRFGSPEEVANVVLFLCSELASYIT 237 Query: 232 GSTLPVEGGFW 242 G + V GG + Sbjct: 238 GEVIHVNGGMF 248 >1CYD-A nrPDB Length = 244 Score = 275 bits (704), Expect = 1e-74, Method: Composition-based stats. Identities = 165/244 (67%), Positives = 197/244 (80%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 M+L +G R LVTGAGKGIGR TV+ALHA+GA+VVAV+RT +DL SL +ECPGIEPVCVD Sbjct: 1 MKLNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKECPGIEPVCVD 60 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 LGDW+ATE+ALG +GPVDLLVNNAA+ ++QPFLEVTKEAFDRSF VNLR+V QVSQ+VAR Sbjct: 61 LGDWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVAR 120 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 +I RGVPG+IVNVSS + N Y STKGA+ MLTK MA+ELGPHKIRVN+VNPT Sbjct: 121 DMINRGVPGSIVNVSSMVAHVTFPNLITYSSTKGAMTMLTKAMAMELGPHKIRVNSVNPT 180 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 VV+T MG+ +DP A+ + R PL KFAEVE VVN+ILFLLSDRS T+G + V+ G Sbjct: 181 VVLTDMGKKVSADPEFARKLKERHPLRKFAEVEDVVNSILFLLSDRSASTSGGGILVDAG 240 Query: 241 FWAC 244 + A Sbjct: 241 YLAS 244 >2C07-A nrPDB Length = 285 Score = 265 bits (678), Expect = 1e-71, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 111/244 (45%), Gaps = 11/244 (4%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI----EPVCVDL 61 + LVTGAG+GIGR + L + + V+ +SRTQ DS+V E D+ Sbjct: 43 ENKVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDV 102 Query: 62 GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 E + + VD+LVNNA + FL + + ++ NL ++ ++Q Sbjct: 103 SKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQP 162 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 +++ +I G I+N+SS + Y S+K + TK +A EL I VNA+ Sbjct: 163 ISKRMI-NNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAI 221 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + + M K +++ IP G+ E V N FL SD+SG G + Sbjct: 222 APGFISSDMTDKI--SEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVI 279 Query: 238 EGGF 241 +GG Sbjct: 280 DGGL 283 >3RSH-A nrPDB Length = 251 Score = 263 bits (674), Expect = 4e-71, Method: Composition-based stats. Identities = 66/245 (26%), Positives = 119/245 (48%), Gaps = 8/245 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR-ECPGIEPVCVDL 61 + L G+ LVTGA +GIG+ + L GA+V+ + +++ ++ + + +++ Sbjct: 8 MNLEGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYLGDNGKGMALNV 67 Query: 62 GDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + E+ E L G VD+LVNNA + + + +E + E NL ++ ++S+ Sbjct: 68 TNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLSKA 127 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 V RG++ + G I+NV S + Y + K + TK MA E+ + VN V Sbjct: 128 VLRGMMKK-RQGRIINVGSVVGTMGNAGQANYAAAKAGVIGFTKSMAREVASRGVTVNTV 186 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + T M +A + + L ++P G+ + + +A+ FL S + TG TL V Sbjct: 187 APGFIETDMTKAL--NDEQRTATLAQVPAGRLGDPREIASAVAFLASPEAAYITGETLHV 244 Query: 238 EGGFW 242 GG + Sbjct: 245 NGGMY 249 >4JRO-A nrPDB Length = 271 Score = 263 bits (673), Expect = 4e-71, Method: Composition-based stats. Identities = 72/248 (29%), Positives = 115/248 (46%), Gaps = 12/248 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS-----LVRECPGIEPV 57 + L G+ +VTG +GIGR L GA + + + +E + Sbjct: 25 MTLQGKVAVVTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLVAEHGVEVEAM 84 Query: 58 CVDLGDWEATE----RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 ++ E + +A+ G VD+LVNNA + + + ++ +D +NL+ Sbjct: 85 KANVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDEWDDVININLKGTFL 144 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ V+R ++ + G I+N++S + Y ++K + LTK A EL P I Sbjct: 145 CTKAVSRTMMKQ-RAGKIINMASVVGLIGNAGQANYVASKAGVIGLTKTTARELAPRGIN 203 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VNAV P + T M D + ML +IPLG + E + NA+LFL SD S TG Sbjct: 204 VNAVAPGFITTDMTDKL--DEKTKEAMLAQIPLGAYGTTEDIANAVLFLASDASKYITGQ 261 Query: 234 TLPVEGGF 241 TL V+GG Sbjct: 262 TLSVDGGM 269 >3F9I-A nrPDB Length = 249 Score = 260 bits (664), Expect = 5e-70, Method: Composition-based stats. Identities = 65/239 (27%), Positives = 113/239 (47%), Gaps = 4/239 (1%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPV-CVDLGD 63 L G+ L+TGA GIG + LH G++V+ + L SL + +L + Sbjct: 12 LTGKTSLITGASSGIGSAIARLLHKLGSKVIISGSNEEKLKSLGNALKDNYTIEVCNLAN 71 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 E + +D+LV NA + + + + FD+ ++NL+A +++ + +I Sbjct: 72 KEECSNLISKTSNLDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFILNREAIKKMI 131 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 + G I+N+SS + YC++K L +TK ++ E+ I VNAV P + Sbjct: 132 QK-RYGRIINISSIVGIAGNPGQANYCASKAGLIGMTKSLSYEVATRGITVNAVAPGFIK 190 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 + M + + + ++ +IPLG + E V A+ FL S+ + TG TL V GG Sbjct: 191 SDMTDKL--NEKQREAIVQKIPLGTYGIPEDVAYAVAFLASNNASYITGQTLHVNGGML 247 >2UVD-A nrPDB Length = 246 Score = 259 bits (662), Expect = 9e-70, Method: Composition-based stats. Identities = 77/247 (31%), Positives = 112/247 (45%), Gaps = 12/247 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-----LDSLVRECPGIEPVC 58 L G+ LVTGA +GIGR L GA VV +D + + V Sbjct: 1 MLKGKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVR 60 Query: 59 VDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + E ++ + G VD+LVNNA V + + +E +D NL+ V Sbjct: 61 ADVANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVFLC 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 ++ V+R ++ R G IVN++S + Y + K + LTK A EL I V Sbjct: 121 TKAVSRFMM-RQRHGRIVNIASVVGVTGNPGQANYVAAKAGVIGLTKTSAKELASRNITV 179 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 NA+ P + T M D + ML IP +F E + + NA+ F SD+S TG T Sbjct: 180 NAIAPGFIATDMTDVL--DENIKAEMLKLIPAAQFGEAQDIANAVTFFASDQSKYITGQT 237 Query: 235 LPVEGGF 241 L V+GG Sbjct: 238 LNVDGGM 244 >3EMK-A nrPDB Length = 246 Score = 258 bits (659), Expect = 2e-69, Method: Composition-based stats. Identities = 70/242 (28%), Positives = 116/242 (47%), Gaps = 8/242 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPVCVDLGD 63 L GR+ LVTGA G+G +ALHA GA V + L L E I +L D Sbjct: 5 LTGRKALVTGATGGLGEAIARALHAQGAIVGLHGTREEKLKELAAELGERIFVFPANLSD 64 Query: 64 WEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 EA ++A +G VD+LVNNA + F+ ++ E +D VNL +V +++ + Sbjct: 65 REAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFNLTRELT 124 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 ++ R G I+N++S + YC++K L +K +A E+ + VN + P Sbjct: 125 HPMMRR-RNGRIINITSIVGVTGNPGQANYCASKAGLIGFSKSLAQEIASRNVTVNCIAP 183 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 + ++M + + ++ IP+ + + A+++L SD + TG TL V G Sbjct: 184 GFIESAMTGKL--NEKQKDAIMGNIPMKRMGVGADIAAAVVYLASDEAAYVTGQTLHVNG 241 Query: 240 GF 241 G Sbjct: 242 GM 243 >3OSU-A nrPDB Length = 246 Score = 256 bits (655), Expect = 5e-69, Method: Composition-based stats. Identities = 69/251 (27%), Positives = 114/251 (45%), Gaps = 15/251 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSR-TQADLDSLVRECPG----IE 55 M++ + LVTGA +GIGR L G V ++ +++V E Sbjct: 1 MKMT---KSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSF 57 Query: 56 PVCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 + ++ D + + + G +D+LVNNA + + + ++ +D + NL+ V Sbjct: 58 AIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGV 117 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 Q ++ R GAI+N+SS + Y +TK + LTK A EL Sbjct: 118 FNCIQKATPQML-RQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRG 176 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 I VNAV P +++ M A + ML +IPL +F + + N + FL SD++ T Sbjct: 177 ITVNAVAPGFIVSDMTDALSD--ELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYIT 234 Query: 232 GSTLPVEGGFW 242 G T+ V GG + Sbjct: 235 GQTIHVNGGMY 245 >5ITV-A nrPDB Length = 255 Score = 255 bits (652), Expect = 1e-68, Method: Composition-based stats. Identities = 76/255 (29%), Positives = 127/255 (49%), Gaps = 13/255 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG--IEPVC 58 M + L + VL+TG GIG VQA A VV +A +++VR+ + V Sbjct: 1 MIMNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQ 60 Query: 59 VDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ D A E A+ + G +D+L+NNA + ++ P E+ +++ +VNL + + Sbjct: 61 TDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLM 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ + ++A G G I+N S A + Y ++KG + LTK MA++ H+IRV Sbjct: 121 SKHALKHMLAAGK-GNIINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDYAKHQIRV 179 Query: 175 NAVNPTVVMTSMGQATWSD------PHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 N V P ++ T + + ++ + K PL + + E + N +LFL SD S Sbjct: 180 NCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSS 239 Query: 229 MTTGSTLPVEGGFWA 243 TGS + +GG+ A Sbjct: 240 YMTGSAITADGGYTA 254 >5CDY-A nrPDB Length = 244 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 112/245 (45%), Gaps = 8/245 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-VRECPGIEPVCVDL 61 + G+ LVTGA +GIGR + L GA V+ + ++ +++ + + +++ Sbjct: 1 MSFEGKIALVTGASRGIGRAIAELLVERGACVIGTATSEKGAEAISAYLGENGKGLMLNV 60 Query: 62 GDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D + + L G VD+LVNNA + + + + + + NL +V ++S+ Sbjct: 61 VDPTSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRLSKA 120 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 V R ++ + G I+ + S Y + K + +K +A E+ I VN V Sbjct: 121 VMRAMMKK-RFGRIITIGSVVGTMGNAGQVNYAAAKAGVIGFSKSLAREVASRGITVNVV 179 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + T M + D +L ++P + + + + +A+ FL SD + +G TL V Sbjct: 180 APGFIETDMTRTLTDDQR--AGILAQVPANRLGDAKEIASAVAFLASDEASYISGETLHV 237 Query: 238 EGGFW 242 GG + Sbjct: 238 NGGMY 242 >3LYL-A nrPDB Length = 247 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 61/248 (24%), Positives = 114/248 (45%), Gaps = 11/248 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS----LVRECPGIEPVC 58 + L + LVTGA +GIG AL + GA VV + +QA + + + + Sbjct: 1 MSLNEKVALVTGASRGIGFEVAHALASKGATVVGTATSQASAEKFENSMKEKGFKARGLV 60 Query: 59 VDLGDWEATERALGSVGP----VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +++ D E+ + + +D+LVNNA + + ++++ + NL ++ ++ Sbjct: 61 LNISDIESIQNFFAEIKAENLAIDILVNNAGITRDNLMMRMSEDEWQSVINTNLSSIFRM 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+ RG++ + G I+++ S + YC+ K + +K +A E+ I V Sbjct: 121 SKECVRGMMKKRW-GRIISIGSVVGSAGNPGQTNYCAAKAGVIGFSKSLAYEVASRNITV 179 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 N V P + T M + + +IP G+ E + + A+ FL S+ + TG T Sbjct: 180 NVVAPGFIATDMTDKLTD--EQKSFIATKIPSGQIGEPKDIAAAVAFLASEEAKYITGQT 237 Query: 235 LPVEGGFW 242 L V GG + Sbjct: 238 LHVNGGMY 245 >3FTP-A nrPDB Length = 270 Score = 254 bits (650), Expect = 2e-68, Method: Composition-based stats. Identities = 69/250 (27%), Positives = 121/250 (48%), Gaps = 11/250 (4%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD----SLVRECPGIEP 56 M+ L + +VTGA +GIGR L GA V+ + T+A + + + Sbjct: 22 MDKTLDKQVAIVTGASRGIGRAIALELARRGAMVIGTATTEAGAEGIGAAFKQAGLEGRG 81 Query: 57 VCVDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 +++ D A + + G +++LVNNA + Q + + + +D + NL+AV Sbjct: 82 AVLNVNDATAVDALVESTLKEFGALNVLVNNAGITQDQLAMRMKDDEWDAVIDTNLKAVF 141 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 ++S+ V R ++ + G IVN++S Y + K + +T+ +A E+G I Sbjct: 142 RLSRAVLRPMM-KARGGRIVNITSVVGSAGNPGQVNYAAAKAGVAGMTRALAREIGSRGI 200 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 VN V P + T M + + A + +IPLG+ E + +A+ FL S ++G TG Sbjct: 201 TVNCVAPGFIDTDMTKGLPQEQQTA--LKTQIPLGRLGSPEDIAHAVAFLASPQAGYITG 258 Query: 233 STLPVEGGFW 242 +TL V GG + Sbjct: 259 TTLHVNGGMF 268 >2HQ1-A nrPDB Length = 247 Score = 254 bits (649), Expect = 3e-68, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 111/248 (44%), Gaps = 12/248 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ-----ADLDSLVRECPGIEPV 57 + L G+ +VTG+ +G+G+ L GA +V A + + Sbjct: 1 MQLKGKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLDATAEEFKAAGINVVVA 60 Query: 58 CVDLGDWEATE----RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ + E E A+ + G +D+LVNNA + L+++++ +D NL++ Sbjct: 61 KGDVKNPEDVENMVKTAMDAFGRIDILVNNAGITRDTLMLKMSEKDWDDVLNTNLKSAYL 120 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ V++ ++ + G I+N++S + Y ++K L TK +A E I Sbjct: 121 CTKAVSKIMLKQ-KSGKIINITSIAGIIGNAGQANYAASKAGLIGFTKSIAKEFAAKGIY 179 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 NAV P ++ T M + LN IPL +F E V N + FL SD S TG Sbjct: 180 CNAVAPGIIKTDMTDVLPDKV--KEMYLNNIPLKRFGTPEEVANVVGFLASDDSNYITGQ 237 Query: 234 TLPVEGGF 241 + ++GG Sbjct: 238 VINIDGGL 245 >1Q7C-A nrPDB Length = 244 Score = 254 bits (649), Expect = 3e-68, Method: Composition-based stats. Identities = 67/245 (27%), Positives = 116/245 (47%), Gaps = 8/245 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR-ECPGIEPVCVDL 61 + G+ LVTGA +GIGR + L A GA+V+ + ++ ++ + + +++ Sbjct: 1 MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNV 60 Query: 62 GDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D + E L G VD+LVNNA + + + E ++ E NL +V ++S+ Sbjct: 61 TDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKA 120 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 V R ++ + G I+ + S + + + K L +K +A E+ I VN V Sbjct: 121 VMRAMMKK-RHGRIITIGSVVGTMGNGGQANFAAAKAGLIGFSKSLAREVASRGITVNVV 179 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + T M +A D +L ++P G+ + + NA+ FL SD + TG TL V Sbjct: 180 APGFIETDMTRALSDDQR--AGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHV 237 Query: 238 EGGFW 242 GG + Sbjct: 238 NGGMY 242 >4M8S-A nrPDB Length = 248 Score = 249 bits (637), Expect = 8e-67, Method: Composition-based stats. Identities = 73/244 (29%), Positives = 124/244 (50%), Gaps = 9/244 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP--GIEPVCVDLG 62 L+G+ LVTGA +GIG L A GA+V+ + +++ ++ G E ++ Sbjct: 6 LSGKIALVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGGEGRVLNSA 65 Query: 63 DWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + E E + + G +D+LVNNA + + + +E +D +VNL++V + S+ V Sbjct: 66 EPETVENLIADIEKTFGKLDILVNNAGITRDNLLMRMKEEEWDDIMQVNLKSVFRASKAV 125 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 RG++ + G I+N++S + Y + K L +K MA E+G I VN V Sbjct: 126 LRGMMKQ-RAGRIINITSVVGVMGNAGQTNYAAAKAGLIGFSKSMAREVGSRGITVNCVA 184 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P + T M +A + + T + LG+F + + + +A+LFL SD++ TG TL V Sbjct: 185 PGFIDTDMTRALPEETRQ--TFTAQTALGRFGDAQDIADAVLFLASDQAKYITGQTLHVN 242 Query: 239 GGFW 242 GG Sbjct: 243 GGML 246 >3WOH-A nrPDB Length = 251 Score = 247 bits (631), Expect = 4e-66, Method: Composition-based stats. Identities = 73/246 (29%), Positives = 106/246 (43%), Gaps = 14/246 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-----QADLDSLVRECPGIEPVCV 59 L+G+ LVTG +G+GR L GA V V + + + R Sbjct: 9 LSGKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARSYRC 68 Query: 60 DLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ D E R + +V GPVD+LVNNA + + E +D NL+ Sbjct: 69 DVSDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLFI 128 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + G I R G+I+N+SS + Y S K L LTK +A EL +R N Sbjct: 129 KACYFGFI-RKRSGSIINISSVSGVFGSAGQANYASAKAGLIGLTKSIAKELAERNVRCN 187 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 AV P ++ T M Q D + L+ +P+ +F + V + FL D S TG + Sbjct: 188 AVAPGLIATDMTQDLVDDSKR----LDPVPMRRFGRPDEVAGLVAFLAGDESSYITGQVV 243 Query: 236 PVEGGF 241 V+GG Sbjct: 244 CVDGGM 249 >1AE1-A nrPDB Length = 273 Score = 246 bits (629), Expect = 7e-66, Method: Composition-based stats. Identities = 76/253 (30%), Positives = 126/253 (49%), Gaps = 14/253 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR----ECPGIEPVCV 59 L G LVTG KGIG V+ L GARV SR + +LD + + +E Sbjct: 18 SLKGTTALVTGGSKGIGYAIVEELAGLGARVYTCSRNEKELDECLEIWREKGLNVEGSVC 77 Query: 60 DLGDWEATERALGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 DL ++ + +V G +++LVNNA V + + + T++ ++ N A + Sbjct: 78 DLLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAYHL 137 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 SQI L+ G ++ +SS A+ + S+Y ++KGA++ +TK +A E IRV Sbjct: 138 SQIAYP-LLKASQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACEWAKDNIRV 196 Query: 175 NAVNPTVVMTSMGQ-ATWSDPHKAKTMLNRI---PLGKFAEVEHVVNAILFLLSDRSGMT 230 N+V P V++T + + A +PH+ + + N I P+G+ + + V I FL + Sbjct: 197 NSVAPGVILTPLVETAIKKNPHQKEEIDNFIVKTPMGRAGKPQEVSALIAFLCFPAASYI 256 Query: 231 TGSTLPVEGGFWA 243 TG + +GGF A Sbjct: 257 TGQIIWADGGFTA 269 >3O4R-A nrPDB Length = 261 Score = 244 bits (623), Expect = 3e-65, Method: Composition-based stats. Identities = 79/245 (32%), Positives = 124/245 (50%), Gaps = 10/245 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 LA + LVT + GIG + L GA VV SR Q ++D V G + Sbjct: 13 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 72 Query: 61 LGDWEATERALGS----VGPVDLLVNNAAVALL-QPFLEVTKEAFDRSFEVNLRAVIQVS 115 +G E ER + + G +D+LV+NAAV ++VT+E +D++ ++N++A ++ Sbjct: 73 VGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMT 132 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V + RG G++V VSS + S Y +K AL LTK +A+EL P IRVN Sbjct: 133 KAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 191 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 + P ++ TS + W D K ++M + + + E E + FL S+ + TG T+ Sbjct: 192 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETV 251 Query: 236 PVEGG 240 V GG Sbjct: 252 VVGGG 256 >3GRP-A nrPDB Length = 266 Score = 243 bits (620), Expect = 7e-65, Method: Composition-based stats. Identities = 61/244 (25%), Positives = 110/244 (45%), Gaps = 8/244 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP-GIEPVCVDL 61 L GR+ LVTGA GIG + HA GA V + L + + + +L Sbjct: 23 FKLTGRKALVTGATGGIGEAIARCFHAQGAIVGLHGTREDKLKEIAADLGKDVFVFSANL 82 Query: 62 GDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D ++ ++ + +D+LVNNA + F+ + + +D VNL A +++ Sbjct: 83 SDRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAASTLTRE 142 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + ++ R G I+N++S + YC+ K L +K +A E+ I VN + Sbjct: 143 LIHSMMRR-RYGRIINITSIVGVVGNPGQTNYCAAKAGLIGFSKALAQEIASRNITVNCI 201 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + ++M + + + ++ IP+ + E + A ++L SD + TG TL + Sbjct: 202 APGFIKSAMTDKL--NEKQKEAIMAMIPMKRMGIGEEIAFATVYLASDEAAYLTGQTLHI 259 Query: 238 EGGF 241 GG Sbjct: 260 NGGM 263 >2AE2-A nrPDB Length = 260 Score = 241 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 75/252 (29%), Positives = 121/252 (48%), Gaps = 13/252 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCV 59 L G LVTG +GIG G V+ L + GA V SR Q +L+ + + +E Sbjct: 6 NLEGCTALVTGGSRGIGYGIVEELASLGASVYTCSRNQKELNDCLTQWRSKGFKVEASVC 65 Query: 60 DLGDWEATERALGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 DL + + +V G +++LVNNA + + + + T E + +N A + Sbjct: 66 DLSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYHL 125 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S ++A + G +V +SS AV +VY +TKGA+D LT+ +A E IRV Sbjct: 126 S-VLAHPFLKASERGNVVFISSVSGALAVPYEAVYGATKGAMDQLTRCLAFEWAKDNIRV 184 Query: 175 NAVNPTVVMTSMGQATWSDPHKAK---TMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 N V P V+ TS+ + T DP + + +++R L + E + + + FL + T Sbjct: 185 NGVGPGVIATSLVEMTIQDPEQKENLNKLIDRCALRRMGEPKELAAMVAFLCFPAASYVT 244 Query: 232 GSTLPVEGGFWA 243 G + V+GG A Sbjct: 245 GQIIYVDGGLMA 256 >4Z9Y-A nrPDB Length = 253 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 74/248 (29%), Positives = 129/248 (52%), Gaps = 6/248 (2%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ-----ADLDSLVRECPGIEP 56 L G+ L+TG G+G+G L G +V V+ + + +L R + Sbjct: 5 SFDLQGKVALITGCDTGLGQGMAIGLAQAGCDIVGVNIVEPKDTIEKVTALGRRFLSLTA 64 Query: 57 VCVDL-GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 ++ G E E+A+ G VD+LVNNA + + +E +++ +D +N+++V +S Sbjct: 65 DMSNVSGHAELVEKAVAEFGHVDILVNNAGIIRREDAIEFSEKNWDDVMNLNIKSVFFMS 124 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 Q VAR I +G G I+N++S S + Y ++K A+ +T++MA E H I VN Sbjct: 125 QTVARQFIKQGKGGKIINIASMLSFQGGIRVPSYTASKSAVMGVTRLMANEWAKHGINVN 184 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 A+ P + T+ Q +D ++K +L+RIP G++ + ++ +FL S S G T+ Sbjct: 185 AIAPGYMATNNTQQLRADEERSKEILDRIPAGRWGLPQDLMGPSVFLASSASDYINGYTI 244 Query: 236 PVEGGFWA 243 V+GG+ A Sbjct: 245 AVDGGWLA 252 >1GEE-A nrPDB Length = 261 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 113/251 (45%), Gaps = 9/251 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-----LDSLVRECPGIE 55 M L G+ V++TG+ G+G+ A+VV R++ D L+ + + Sbjct: 1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAI 60 Query: 56 PVCVDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 V D+ + A+ G +D+++NNA + E++ +++ + NL Sbjct: 61 AVKGDVTVESDVINLVQSAIKEFGKLDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGA 120 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 S+ + + + G ++N+SS + Y ++KG + ++T+ +ALE P Sbjct: 121 FLGSREAIKYFVENDIKGTVINMSSVHEKIPWPLFVHYAASKGGMKLMTETLALEYAPKG 180 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 IRVN + P + T + ++DP + + + IP+G E E + +L S + T Sbjct: 181 IRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEEIAAVAAWLASSEASYVT 240 Query: 232 GSTLPVEGGFW 242 G TL +GG Sbjct: 241 GITLFADGGMT 251 >2NM0-A nrPDB Length = 253 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 110/238 (46%), Gaps = 14/238 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG +A G +V R+ + G V D+ D E Sbjct: 22 RSVLVTGGNRGIGLAIARAFADAGDKVAITYRSGEPPE-------GFLAVKCDITDTEQV 74 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 E+A + GPV++L+ NA V Q + +++E F E NL +V + R ++ Sbjct: 75 EQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRVVKRANRAML 134 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G +V +SS + Y ++K L + +A ELG I N V P V Sbjct: 135 -RAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITFNVVAPGFVD 193 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M + + +++++PLG++A E + + FL SD + TG+ +PV+GG Sbjct: 194 TDMTKVLTD--EQRANIVSQVPLGRYARPEEIAATVRFLASDDASYITGAVIPVDGGL 249 >4BO1-A nrPDB Length = 269 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 115/249 (46%), Gaps = 11/249 (4%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPV 57 + L G+ LVTGA +GIG+ L GA V+ + + + + + + Sbjct: 22 SMSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGL 81 Query: 58 CVDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 +D+ E+ L + G ++VNNA + + + + + NL ++ + Sbjct: 82 VLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYR 141 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 +S+ V RG+ + G I+N+ S + Y + K L+ T+ +A E+G I Sbjct: 142 LSKAVLRGM-TKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAIT 200 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VNAV P + T M + + + +L +IPLG+ + E + + FL SD + TG+ Sbjct: 201 VNAVAPGFIDTDMTRELP--EAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGA 258 Query: 234 TLPVEGGFW 242 T+PV GG + Sbjct: 259 TVPVNGGMY 267 >4KMS-A nrPDB Length = 249 Score = 239 bits (611), Expect = 7e-64, Method: Composition-based stats. Identities = 66/237 (27%), Positives = 109/237 (45%), Gaps = 8/237 (3%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 +VTG +GIG+ T L G VVA + D + E GI+ C ++ D+E Sbjct: 12 IAIVTGGTRGIGKATALELKNKGLTVVANFFSNYDAAKEMEEKYGIKTKCWNVADFEECR 71 Query: 69 RALGSVG-----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +A+ + PV +LVNNA + + ++ + ++ VNL + +S V + Sbjct: 72 QAVKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMSSSVMEQMR 131 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 + G IVN+SS +Q + Y + K + TK +A E I VN + P + Sbjct: 132 NQDY-GRIVNISSINAQAGQVGQTNYSAAKAGIIGFTKALARETASKNITVNCIAPGYIA 190 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 T M A D ++N IP + + E + A+ FL+ + +G TG T+ + GG Sbjct: 191 TEMVGAVPEDV--LAKIINSIPKKRLGQPEEIARAVAFLVDENAGFITGETISINGG 245 >3AUT-A nrPDB Length = 269 Score = 239 bits (611), Expect = 7e-64, Method: Composition-based stats. Identities = 64/251 (25%), Positives = 110/251 (43%), Gaps = 9/251 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQA----DLDSLVRECPG-IE 55 M L + V++TG G+GR A+VV D V E G Sbjct: 9 MYTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAI 68 Query: 56 PVCVDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 V D+ E + A+ G +D+++NNA V P E++ + +++ + NL Sbjct: 69 IVQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTGA 128 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 S+ + + + G ++N+SS Y ++KG + ++T+ +ALE P Sbjct: 129 FLGSREAIKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASKGGMKLMTETLALEYAPKG 188 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 IRVN + P + T + ++DP + + + IP+G + E V FL S ++ T Sbjct: 189 IRVNNIGPGAMNTPINAEKFADPVQRADVESMIPMGYIGKPEEVAAVAAFLASSQASYVT 248 Query: 232 GSTLPVEGGFW 242 G TL +GG Sbjct: 249 GITLFADGGMT 259 >2ZAT-A nrPDB Length = 260 Score = 238 bits (609), Expect = 1e-63, Method: Composition-based stats. Identities = 76/245 (31%), Positives = 118/245 (48%), Gaps = 10/245 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60 L + LVT + GIG + L GA VV SR Q ++D V G + Sbjct: 12 LENKVALVTASTDGIGLAIARRLAQDGAHVVVSSRKQENVDRTVATLQGEGLSVTGTVCH 71 Query: 61 LGDWEATERALGS----VGPVDLLVNNAAVALL-QPFLEVTKEAFDRSFEVNLRAVIQVS 115 +G E ER + G VD+LV+NAAV ++ T+E +D+ VN++A + ++ Sbjct: 72 VGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATVLMT 131 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V + RG G+++ VSS + N Y +K AL LTK +A+EL P IRVN Sbjct: 132 KAVVPEMEKRG-GGSVLIVSSVGAYHPFPNLGPYNVSKTALLGLTKNLAVELAPRNIRVN 190 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 + P ++ T+ Q W D + + M + + + E + FL S+ + TG T+ Sbjct: 191 CLAPGLIKTNFSQVLWMDKARKEYMKESLRIRRLGNPEDCAGIVSFLCSEDASYITGETV 250 Query: 236 PVEGG 240 V GG Sbjct: 251 VVGGG 255 >4NBT-A nrPDB Length = 240 Score = 238 bits (609), Expect = 1e-63, Method: Composition-based stats. Identities = 69/243 (28%), Positives = 112/243 (46%), Gaps = 14/243 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+ ++TG KG+G+ A GA+V+A DL L P +E + +++ D Sbjct: 4 LEGKVAVITGGAKGLGQAIALAYAEEGAKVIA-----GDLGDLTYSHPNVEGMYLNVTDV 58 Query: 65 EATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 E+ SV G +D+LVNNA + ++T+ +D +VNL+ V ++++V Sbjct: 59 TGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNLTRLVGP 118 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG--PHKIRVNAVN 178 + G G+I+N+SS + Y +TK + LT A E +RVNA+ Sbjct: 119 QMQTNGY-GSIINISSVVGVFGNIGQANYAATKAGVIGLTMTWAKEFALKGANVRVNAIA 177 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P +MT + + D L + + E + LFL SD + TG T+ V Sbjct: 178 PGYIMTDILKTVPQD--LLDKFAALTMLNRLGQPEEIAKVALFLASDDASYVTGQTINVN 235 Query: 239 GGF 241 GG Sbjct: 236 GGM 238 >6NRP-A nrPDB Length = 263 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 14/243 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-QADLDSLVRECPGI----EPVCVDLG 62 RR+LVTG+ +GIG+ L G V +R+ QA+ + +V+E + + D+ Sbjct: 25 RRILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQNSHYLMFDVN 84 Query: 63 DWEATERA----LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + + ++ + G +V NA + F +T + +D +L V + + Sbjct: 85 ERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDGFYNVLKPL 144 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 +I G IV +SS Y + K L TK +ALEL KI VN V Sbjct: 145 IMPMIHLRKGGRIVTLSSVSGIMGNRGQVNYSAAKAGLIGATKALALELAKRKITVNCVA 204 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P ++ T M + L IPL + +V+ V + + FL SD + T + V Sbjct: 205 PGLIETEMVT-----DEVKEHALKMIPLQRMGQVDEVASVVKFLCSDEASYVTRQVISVN 259 Query: 239 GGF 241 GG Sbjct: 260 GGL 262 >4K6F-A nrPDB Length = 255 Score = 237 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 70/245 (28%), Positives = 112/245 (45%), Gaps = 11/245 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSR-----TQADLDSLVRECPGIEPVCV 59 + R +VTG G+G L+ G RVV L + V Sbjct: 9 MTKRIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPV 68 Query: 60 DLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ D ++ ++ + VGPVD+LVNNA + ++ K +D NL +V ++ Sbjct: 69 DVADHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMT 128 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V G++ RG G IVN+SS + + Y + K + TK +ALE+ + VN Sbjct: 129 KPVCDGMVERGW-GRIVNISSVNGSKGSVGQTNYAAAKAGMHGFTKSLALEIARKGVTVN 187 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 V+P + T M A D K +L +IP G+ + E V + +L S+ +G TGS + Sbjct: 188 TVSPGYLATKMVTAIPQDILDTK-ILPQIPAGRLGKPEEVAALVAYLCSEEAGFVTGSNI 246 Query: 236 PVEGG 240 + GG Sbjct: 247 AINGG 251 >3EZL-A nrPDB Length = 256 Score = 237 bits (605), Expect = 4e-63, Method: Composition-based stats. Identities = 69/249 (27%), Positives = 119/249 (47%), Gaps = 12/249 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLVRECPGIEPV 57 + ++ R VTG GIG Q LH G RVVA R L+ Sbjct: 9 MVMSQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYAS 68 Query: 58 CVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 ++GDW++T++A VG +D+LVNNA + F ++T+E + + NL ++ Sbjct: 69 EGNVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFN 128 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 V++ V G++ RG G I+N+SS Q+ + Y + K + T +A E+ + Sbjct: 129 VTKQVIDGMVERGW-GRIINISSVNGQKGQFGQTNYSTAKAGIHGFTMSLAQEVATKGVT 187 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VN V+P + T M +A P + ++ IP+ + + + + + +L S+ SG +TG+ Sbjct: 188 VNTVSPGYIGTDMVKAIR--PDVLEKIVATIPVRRLGSPDEIGSIVAWLASEESGFSTGA 245 Query: 234 TLPVEGGFW 242 + GG Sbjct: 246 DFSLNGGLH 254 >2PH3-A nrPDB Length = 245 Score = 236 bits (604), Expect = 5e-63, Method: Composition-based stats. Identities = 67/245 (27%), Positives = 108/245 (44%), Gaps = 13/245 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG------IEPVCVDL 61 R+ L+TGA +GIGR L G + + V E + + +L Sbjct: 2 RKALITGASRGIGRAIALRLAEDGFALAIHYGQNREKAEEVAEEARRRGSPLVAVLGANL 61 Query: 62 GDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + EA + +G +D LVNNA + + + E ++ E NL AV + ++ Sbjct: 62 LEAEAATALVHQAAEVLGGLDTLVNNAGITRDTLLVRMKDEDWEAVLEANLSAVFRTTRE 121 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + ++ G IVN++S + Y ++K L T+ +A E I VNAV Sbjct: 122 AVKLMMKA-RFGRIVNITSVVGILGNPGQANYVASKAGLIGFTRAVAKEYAQRGITVNAV 180 Query: 178 NPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPV 237 P + T M + + L +IP G+F E V A+ FL+S+++G TG TL V Sbjct: 181 APGFIETEMTERLPQ--EVKEAYLKQIPAGRFGRPEEVAEAVAFLVSEKAGYITGQTLCV 238 Query: 238 EGGFW 242 +GG Sbjct: 239 DGGLT 243 >4DMM-A nrPDB Length = 269 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 70/249 (28%), Positives = 108/249 (43%), Gaps = 16/249 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC---- 58 L L R LVTGA +GIGR L A GA+V + A V Sbjct: 24 LPLTDRIALVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAV 83 Query: 59 -VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ E +V G +D+LVNNA + L + ++ + ++NL V Sbjct: 84 KADVSQESEVEALFAAVIERWGRLDVLVNNAGITRDTLLLRMKRDDWQSVLDLNLGGVFL 143 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 S+ A+ ++ + G I+N++S + + Y + K + LTK +A EL I Sbjct: 144 CSRAAAKIMLKQ-RSGRIINIASVVGEMGNPGQANYSAAKAGVIGLTKTVAKELASRGIT 202 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTG 232 VNAV P + T M A+ +L IPLG++ E V + FL +D + TG Sbjct: 203 VNAVAPGFIATDMTSEL-----AAEKLLEVIPLGRYGEAAEVAGVVRFLAADPAAAYITG 257 Query: 233 STLPVEGGF 241 + ++GG Sbjct: 258 QVINIDGGL 266 >3OEC-A nrPDB Length = 317 Score = 234 bits (598), Expect = 2e-62, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 117/274 (42%), Gaps = 35/274 (12%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLVR-- 49 L G+ +TGA +G GR L GA +VA+ + +L VR Sbjct: 43 RLQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLV 102 Query: 50 --ECPGIEPVCVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRS 103 + I D+ D + + AL G +D+LV+N ++ + +T + + Sbjct: 103 EEQGRRIIARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDI 162 Query: 104 FEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVM 163 + NL + V +I RG G+++ VSS R S Y ++K + L + Sbjct: 163 LQTNLIGAWHACRAVLPSMIERGQGGSVIFVSSTVGLRGAPGQSHYAASKHGVQGLMLSL 222 Query: 164 ALELGPHKIRVNAVNPTVVMTSMG--------------QATWSDPHKAKTMLNRIPLGKF 209 A E+G H IRVN+VNP V T M T D + + L +P+ + Sbjct: 223 ANEVGRHNIRVNSVNPGAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPI-PW 281 Query: 210 AEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243 E E V NA+ +L SD + G+ +PV+GG A Sbjct: 282 VEPEDVSNAVAWLASDEARYIHGAAIPVDGGQLA 315 >4HP8-A nrPDB Length = 247 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 78/243 (32%), Positives = 125/243 (51%), Gaps = 3/243 (1%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD--LDSLVRECPGIEPVCVD 60 L GR+ LVTGA G+G+ L A GA VV +R D LD + ++ + +D Sbjct: 5 FSLEGRKALVTGANTGLGQAIAVGLAAAGAEVVCAARRAPDETLDIIAKDGGNASALLID 64 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 D A + + G D+LVNNA + +E ++ +D +VNL+A+ +Q A+ Sbjct: 65 FADPLAAKDSFTDAG-FDILVNNAGIIRRADSVEFSELDWDEVMDVNLKALFFTTQAFAK 123 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 L+A+G G +VN++S S + Y + K + LTK++A E I VNA+ P Sbjct: 124 ELLAKGRSGKVVNIASLLSFQGGIRVPSYTAAKHGVAGLTKLLANEWAAKGINVNAIAPG 183 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + T+ +A +D + K +L RIP G++ E + A +FL S + G+ L V+GG Sbjct: 184 YIETNNTEALRADAARNKAILERIPAGRWGHSEDIAGAAVFLSSAAADYVHGAILNVDGG 243 Query: 241 FWA 243 + A Sbjct: 244 WLA 246 >4IIN-A nrPDB Length = 271 Score = 233 bits (596), Expect = 4e-62, Method: Composition-based stats. Identities = 73/249 (29%), Positives = 116/249 (46%), Gaps = 12/249 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD--------LDSLVRECPGI 54 + G+ VL+TGA KGIG + L + G +V R+ A+ L+ + I Sbjct: 25 MQFTGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVI 84 Query: 55 EPVCVDLGDW-EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 + D+ EA + + S G + LVNNA V + +++ E F + NL + Sbjct: 85 KFDAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFI 144 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + + + ++ G++VNV+S +R + Y ++KG + ++K A E IR Sbjct: 145 GCREALKVM-SKSRFGSVVNVASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGALRNIR 203 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N+V P + T M A D KA + IPL + + V A+ FLLSD S TG Sbjct: 204 FNSVTPGFIETDM-NANLKDELKADYV-KNIPLNRLGSAKEVAEAVAFLLSDHSSYITGE 261 Query: 234 TLPVEGGFW 242 TL V GG + Sbjct: 262 TLKVNGGLY 270 >5OVL-A nrPDB Length = 300 Score = 233 bits (595), Expect = 5e-62, Method: Composition-based stats. Identities = 68/238 (28%), Positives = 105/238 (44%), Gaps = 14/238 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG + L A G +V R D L V D+ D A Sbjct: 69 RSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLF-------GVQCDVTDSAAV 121 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA V GPV++LV NA ++ + +T+E F+ NL + +Q +R + Sbjct: 122 DRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASRTM- 180 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G I+ + S + N + Y + K L + + ++ EL + N V P + Sbjct: 181 QRKRFGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSISRELAKAGVTANVVAPGYID 240 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M +A D L+ IP + E V A+ FL S+ + G+ +PV+GG Sbjct: 241 TEMTRAL--DERIQAGALDFIPAKRVGTAEEVAGAVSFLASEDASYIAGAVIPVDGGM 296 >4CQL-A nrPDB Length = 261 Score = 233 bits (595), Expect = 6e-62, Method: Composition-based stats. Identities = 72/249 (28%), Positives = 112/249 (44%), Gaps = 18/249 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----------IEPVC 58 LVTGAG GIGR L GA V A +A VR G Sbjct: 14 ALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQ 73 Query: 59 VDLGDWEATERALGSVGPV-----DLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ + A L V ++V+ A + + L ++++ +D+ VNL+ Sbjct: 74 ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFL 133 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 V+Q A+ L++ G G+I+N+SS + + Y ++K + LT+ A ELG H IR Sbjct: 134 VTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIR 193 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N+V P + T M Q + IP+G + E V + + FL S+ SG TG+ Sbjct: 194 CNSVLPGFIATPMTQKVPQKV--VDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGT 251 Query: 234 TLPVEGGFW 242 ++ V GG + Sbjct: 252 SVEVTGGLF 260 >5U9P-A nrPDB Length = 265 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 9/249 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR----ECPGIEPVC 58 L GRR L+TG+G+GIG + L GA +V R + +L R E + Sbjct: 16 FRLDGRRALITGSGRGIGLTLARGLAEAGAAIVINDRNEEKAATLARRFRDEGFAADHAV 75 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + A+ G +D+LVNNA + P + + VNL V V Sbjct: 76 FDVAEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMRVNLDGVFNV 135 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 +Q VAR +IARG G I+N+ S S+ A + Y +TKGA+ MLTK M + + I+ Sbjct: 136 AQAVARHMIARGH-GKIINICSVQSELARPTIAPYAATKGAVRMLTKGMCADWARYGIQA 194 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 N + P T + +A D + + R P G++ +V+ + A +FL S S G T Sbjct: 195 NGLAPGYFETELNRALVDDAAFSDWLCKRTPAGRWGQVDELCGAAIFLASAASDFVNGQT 254 Query: 235 LPVEGGFWA 243 L V+GG + Sbjct: 255 LFVDGGLTS 263 >5VT6-A nrPDB Length = 269 Score = 231 bits (590), Expect = 2e-61, Method: Composition-based stats. Identities = 77/246 (31%), Positives = 114/246 (46%), Gaps = 11/246 (4%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-----LDSLVRECPGIEPVCVD 60 A R VTG G+G + LH G V + D L + VD Sbjct: 24 AKRVAFVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVD 83 Query: 61 LGDWEATERA----LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 + D+E+ ER L G VD+L+NNA + F+++TK +D +L A+ V++ Sbjct: 84 VADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVTK 143 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 G++ R G IVN+ S R + Y S K + TK +ALE I VN Sbjct: 144 QFIAGMVER-RFGRIVNIGSVNGSRGAFGQANYASAKAGIHGFTKTLALETAKRGITVNT 202 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 V+P + T+M +A D +AK +L +IP+G+ + V I FL SD +G TG+ L Sbjct: 203 VSPGYLATAMVEAVPQDVLEAK-ILPQIPVGRLGRPDEVAALIAFLCSDDAGFVTGADLA 261 Query: 237 VEGGFW 242 + GG Sbjct: 262 INGGMH 267 >1O5I-A nrPDB Length = 249 Score = 230 bits (587), Expect = 4e-61, Method: Composition-based stats. Identities = 68/241 (28%), Positives = 107/241 (44%), Gaps = 9/241 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 MEL + + VLV A +GIGR L GA V +R + L G V D Sbjct: 13 MELGIRDKGVLVLAASRGIGRAVADVLSQEGAEVTICARNEELLKR-----SGHRYVVCD 67 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 L + V VD+LV NA F E+T E F + + +I++ + Sbjct: 68 LRK--DLDLLFEKVKEVDILVLNAGGPKAGFFDELTNEDFKEAIDSLFLNMIKIVRNYLP 125 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 + +G G IV ++S + N S + AL K ++ E+ P+ I VN V P Sbjct: 126 AMKEKGW-GRIVAITSFSVISPIENLYTSNSARMALTGFLKTLSFEVAPYGITVNCVAPG 184 Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 T + S K K + ++IP+ + A+ E + + + FL S+++ TG T+ V+GG Sbjct: 185 WTETERVKELLS-EEKKKQVESQIPMRRMAKPEEIASVVAFLCSEKASYLTGQTIVVDGG 243 Query: 241 F 241 Sbjct: 244 L 244 >4RZH-A nrPDB Length = 247 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 66/247 (26%), Positives = 114/247 (46%), Gaps = 16/247 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSR-----TQADLDSLVRECPGIEPVCV 59 L + LVTGA +GIG+ T AL ATG +VV A + ++ V Sbjct: 4 LTAQVALVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQA 63 Query: 60 DLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 ++ + + ++ + + +D+LVNNA + L + E + ++NL V + Sbjct: 64 NVANADEVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLCT 123 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V++ ++ + G I+N++S + Y + K + TK +A EL + VN Sbjct: 124 KAVSKLMLKQ-KSGRIINITSVAGMMGNPGQANYSAAKAGVIGFTKTVAKELASRGVTVN 182 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTGST 234 AV P + T M + ++P +L IPL ++ + E V I FL +D + TG T Sbjct: 183 AVAPGFIATDMTENLNAEP-----ILQFIPLARYGQPEEVAGTIRFLATDPAAAYITGQT 237 Query: 235 LPVEGGF 241 V+GG Sbjct: 238 FNVDGGM 244 >1GEG-A nrPDB Length = 256 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 76/252 (30%), Positives = 109/252 (43%), Gaps = 17/252 (6%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC----PGIEPVCVDLG 62 + LVTGAG+GIG+ L G V A ++ E V VD+ Sbjct: 2 KKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVS 61 Query: 63 DWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D + A E+A ++G D++VNNA VA P +T E D+ + +N++ VI Q Sbjct: 62 DRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGIQAA 121 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G G I+N SQ +VY S+K A+ LT+ A +L P I VN Sbjct: 122 VEAFKKEGHGGKIINACSQAGHVGNPELAVYSSSKFAVRGLTQTAARDLAPLGITVNGYC 181 Query: 179 PTVVMTSMGQATWSDPHKA---------KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 P +V T M +A RI LG+ +E E V + +L S S Sbjct: 182 PGIVKTPMWAEIDRQVSEAAGKPLGYGTAEFAKRITLGRLSEPEDVAACVSYLASPDSDY 241 Query: 230 TTGSTLPVEGGF 241 TG +L ++GG Sbjct: 242 MTGQSLLIDGGM 253 >5OVJ-A nrPDB Length = 256 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 68/238 (28%), Positives = 105/238 (44%), Gaps = 14/238 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG + L A G +V R D L V D+ D A Sbjct: 25 RSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLF-------GVQCDVTDSAAV 77 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA V GPV++LV NA ++ + +T+E F+ NL + +Q +R + Sbjct: 78 DRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASRTM- 136 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G I+ + S + N + Y + K L + + ++ EL + N V P + Sbjct: 137 QRKRFGRIIFIGSVSGMWGIGNQANYAAAKAGLIGMARSISRELAKAGVTANVVAPGYID 196 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M +A D L+ IP + E V A+ FL S+ + G+ +PV+GG Sbjct: 197 TEMTRAL--DERIQAGALDFIPAKRVGTAEEVAGAVSFLASEDASYIAGAVIPVDGGM 252 >3VZS-A nrPDB Length = 257 Score = 226 bits (577), Expect = 6e-60, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 111/244 (45%), Gaps = 12/244 (4%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLVRECPGIEPVCVDLG 62 R VTG GIG Q L G RVVA R + L+ ++ Sbjct: 15 RIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVA 74 Query: 63 DWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 DW++T+ A VG VD+L+NNA + F ++T+ +D + NL ++ V++ V Sbjct: 75 DWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQV 134 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G+ RG G IVN+SS Q+ + Y + K L T +A E+ + VN V+ Sbjct: 135 IDGMADRGW-GRIVNISSVNGQKGQFGQTNYSTAKAGLHGFTMALAQEVATKGVTVNTVS 193 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P + T M +A D ++ IP+ + E + + +L S+ SG +TG+ + Sbjct: 194 PGYIATDMVKAIRQDV--LDKIVATIPVKRLGLPEEIASICAWLSSEESGFSTGADFSLN 251 Query: 239 GGFW 242 GG Sbjct: 252 GGLH 255 >2CDH-G nrPDB Length = 244 Score = 226 bits (577), Expect = 7e-60, Method: Composition-based stats. Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 13/243 (5%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---ECPGIEPVC--VDLGD 63 V+VTGA +GIG+ +L G +V+ A V E G + + D+ Sbjct: 3 VVVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITFGGDVSK 62 Query: 64 WEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 E A+ + G +D++VNNA + + + K +D ++NL V +Q Sbjct: 63 EADVEAMMKTAIDAWGTIDVVVNNAGITRDTLLIRMKKSQWDEVIDLNLTGVFLCTQAAT 122 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 + ++ + G I+N++S + Y + K + +K A E I VN V P Sbjct: 123 KIMMKK-RKGRIINIASVVGLIGNIGQANYAAAKAGVIGFSKTAAREGASRNINVNVVCP 181 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLL-SDRSGMTTGSTLPVE 238 + + M D K +L IPLG+ + E+V + FL S + TG ++ Sbjct: 182 GFIASDMTAKLGEDME--KKILGTIPLGRTGQPENVAGLVEFLALSPAASYITGQAFTID 239 Query: 239 GGF 241 GG Sbjct: 240 GGI 242 >6CI9-A nrPDB Length = 259 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 77/249 (30%), Positives = 109/249 (43%), Gaps = 12/249 (4%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEP 56 M L GR +VTG KGIGRG + G VV R Q DLD V + G + Sbjct: 3 MFTSLEGRSAIVTGGSKGIGRGIAETFANAGVDVVITGRNQDDLDRTVADLSGTRGKVTA 62 Query: 57 VCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 V D+ D E R + G +D++ NA + ++T + ++ VN + + Sbjct: 63 VRADVTDPEDARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTV 122 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCS-QRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 + Q + L A G G +V SS S Y ++K A + A+EL P K Sbjct: 123 YIVQAALQALTASGH-GRVVVTSSITGPITGYPGWSHYGASKAAQLGFLRTAAMELAPKK 181 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 I +NAV P +MT D M + IP G+ V + NA LF +D + T Sbjct: 182 ITINAVLPGNIMTEGLDEMGQD--YLDQMASAIPAGRLGSVADIGNAALFFATDEAAYVT 239 Query: 232 GSTLPVEGG 240 G TL V+GG Sbjct: 240 GQTLVVDGG 248 >2Q2Q-A nrPDB Length = 255 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 72/254 (28%), Positives = 108/254 (42%), Gaps = 16/254 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT--QADLDSLVRECPGIEPVCVDLG 62 L G+ LVTG+ GIG G Q L GA +V L + R DL Sbjct: 2 LKGKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPAPALAEIARHGVKAVHHPADLS 61 Query: 63 DWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D E G VD+LVNNA + + P + E++D+ +NL AV +++ Sbjct: 62 DVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHGTRLA 121 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G+ AR G I+N++S T + Y + K + LTKV+ LE + NA+ Sbjct: 122 LPGMRARNW-GRIINIASVHGLVGSTGKAAYVAAKHGVVGLTKVVGLETATSNVTCNAIC 180 Query: 179 PTVVMTSMGQATWSD---------PHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 P V+T + Q D + + + P F EH+ +LFL S+ Sbjct: 181 PGWVLTPLVQKQIDDRAANGGDPLQAQHDLLAEKQPSLAFVTPEHLGELVLFLCSEAGSQ 240 Query: 230 TTGSTLPVEGGFWA 243 G+ V+GG+ A Sbjct: 241 VRGAAWNVDGGWLA 254 >1UZM-A nrPDB Length = 247 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 67/238 (28%), Positives = 111/238 (46%), Gaps = 14/238 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R VLVTG +GIG Q L A G +V R G+ V VD+ D +A Sbjct: 16 RSVLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAPK-------GLFGVEVDVTDSDAV 68 Query: 68 ERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +RA +V GPV++LV+NA ++ + +T+E F++ NL +V+Q +R + Sbjct: 69 DRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSM- 127 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183 R G ++ + S + N + Y ++K + + + +A EL + N V P + Sbjct: 128 QRNKFGRMIFIGSVSGLWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAPGYID 187 Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 T M +A D + L IP + V + FL S+ + +G+ +PV+GG Sbjct: 188 TDMTRAL--DERIQQGALQFIPAKRVGTPAEVAGVVSFLASEDASYISGAVIPVDGGM 243 >4NBV-A nrPDB Length = 246 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 72/247 (29%), Positives = 105/247 (42%), Gaps = 11/247 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVC 58 + L GR ++TGA GIG T Q GA VV +A + + Sbjct: 1 MKLQGRVAIITGAAAGIGFATAQRFAEDGAIVVLCDVQEARVREAAARLAATGATVSAYR 60 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 VD+ + + + +V VD+LVNNA + ++T+ FD +VNL+ V Sbjct: 61 VDVTRRDEVDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNC 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 +Q VA GL+ G I+N SS + Y ++K + TK A ELGP +RV Sbjct: 121 AQAVA-GLMTEQGKGVILNASSVVGLYGNFGQTNYAASKFGVIGFTKTWARELGPKGVRV 179 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 NAV P V T + Q M + L + AE + + FL SD + G Sbjct: 180 NAVCPGFVNTEILQTVPD--KVLDGMTSSCWLRRLAEPAEIASIYAFLASDDASYVNGVA 237 Query: 235 LPVEGGF 241 + GG Sbjct: 238 IEASGGM 244 >2EW8-A nrPDB Length = 249 Score = 223 bits (569), Expect = 6e-59, Method: Composition-based stats. Identities = 70/249 (28%), Positives = 111/249 (44%), Gaps = 11/249 (4%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP--VC 58 M L + ++TG GIGR + GA + A G V Sbjct: 1 MTQRLKDKLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRNLGRRVLTVK 60 Query: 59 VDLGDWEATE----RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ E + + + G D+LVNNA + L PF E+T E + ++FE+N+ + + Sbjct: 61 CDVSQPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLM 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 ++ G+ G G I+N++S + ++ Y STK A T+ +A +LG I V Sbjct: 121 AKAFVPGMKRNGW-GRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGKDGITV 179 Query: 175 NAVNPTVVMTSMGQ--ATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 NA+ P++V T+ + A + ML IP + + A FL SD + TG Sbjct: 180 NAIAPSLVRTATTEASALSAMFDVLPNMLQAIP--RLQVPLDLTGAAAFLASDDASFITG 237 Query: 233 STLPVEGGF 241 TL V+GG Sbjct: 238 QTLAVDGGM 246 >5T5Q-A nrPDB Length = 247 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 65/249 (26%), Positives = 114/249 (45%), Gaps = 13/249 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC-- 58 M+ R +++TGA GIGR + HA+GA +V + LD+ E + Sbjct: 3 MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATI 62 Query: 59 -VDLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D + E+ A+ G +D LV +A + +PF E++ + R+ +NL V Sbjct: 63 KADASSADDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDGVFY 122 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + + L +IV ++S + R ++ Y +TKGA+ +T+ ++ EL P R Sbjct: 123 LCKRALPALKEDS---SIVTLASLAAYRGAYVNAHYGATKGAMVSMTRALSRELAPK-TR 178 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VN V+P ++ T M + + + PL + + + + I FL S + TG Sbjct: 179 VNGVSPGIIETPMTSELLK--TRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGE 236 Query: 234 TLPVEGGFW 242 T+ V GG + Sbjct: 237 TIQVNGGIY 245 >1YXM-A nrPDB Length = 303 Score = 221 bits (565), Expect = 1e-58, Method: Composition-based stats. Identities = 60/252 (23%), Positives = 104/252 (41%), Gaps = 17/252 (6%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---------I 54 L G+ +VTG GIG+ V+ L G+ VV SR L S E + Sbjct: 15 LLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARV 74 Query: 55 EPVCVDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 P+ ++ + E + + G ++ LVNN L P ++ + + E NL Sbjct: 75 IPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTG 134 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + + V + G+IVN+ ++ + + + LTK +ALE Sbjct: 135 TFYMCKAVYSSWMKE-HGGSIVNII-VPTKAGFPLAVHSGAARAGVYNLTKSLALEWACS 192 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 IR+N V P V+ + + ++ + +IP + E V + + FLLS + Sbjct: 193 GIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAAS 252 Query: 229 MTTGSTLPVEGG 240 TG ++ V+GG Sbjct: 253 FITGQSVDVDGG 264 >4AVY-A nrPDB Length = 242 Score = 221 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 73/237 (30%), Positives = 117/237 (49%), Gaps = 6/237 (2%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 AG++VLVTG GIG GA VVA+ + P I +D+ D + Sbjct: 10 AGQQVLVTGGSSGIGAAIAMQFAELGAEVVALGLDADGV--HAPRHPRIRREELDITDSQ 67 Query: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125 +R ++ +D+LVNNA ++ + E F+R +NL A + SQ+ L R Sbjct: 68 RLQRLFEALPRLDVLVNNAGISRDR--EEYDLATFERVLRLNLSAAMLASQLARPLLAQR 125 Query: 126 GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTS 185 G G+I+N++S S + Y ++KGA+ LT+ +A E +IRVNA+ P + T Sbjct: 126 G--GSILNIASMYSTFGSADRPAYSASKGAIVQLTRSLACEYAAERIRVNAIAPGWIDTP 183 Query: 186 MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 +G +D + ++ R PL ++ E V +A FL + TG+ L V+GG+ Sbjct: 184 LGAGLKADVEATRRIMQRTPLARWGEAPEVASAAAFLCGPGASFVTGAVLAVDGGYL 240 >5OJG-A nrPDB Length = 260 Score = 221 bits (564), Expect = 2e-58, Method: Composition-based stats. Identities = 75/253 (29%), Positives = 117/253 (46%), Gaps = 14/253 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--------ECPGIE 55 G+ +VT A KGIG + L GA VV SR Q ++D + + GI Sbjct: 7 RFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIA 66 Query: 56 PVCVDLGDWEA-TERALGSVGPVDLLVNNAAVALL-QPFLEVTKEAFDRSFEVNLRAVIQ 113 D + + L G +++LVNN + LEV+ + +D+ FEVN++A Q Sbjct: 67 GHIASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQ 126 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++++V + G GAI+ +S + ++ + Y TK L LT+ +A+ L IR Sbjct: 127 MTKLVHPHIAKEG-GGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIR 185 Query: 174 VNAVNPTVVMTSMGQATW---SDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 VN + P V+ T M Q W D K T + I LG+ + + +L SD S Sbjct: 186 VNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYI 245 Query: 231 TGSTLPVEGGFWA 243 TG + + GG A Sbjct: 246 TGEMIIIAGGVQA 258 >4CQM-B nrPDB Length = 244 Score = 220 bits (562), Expect = 3e-58, Method: Composition-based stats. Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 13/241 (5%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-PVCVDLGDWE 65 + V G +GIGR Q + G R+ ++R + + G D+ Sbjct: 9 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 68 Query: 66 ATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 + + G V+ LVN A + + E NL + + R Sbjct: 69 DVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRT 128 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 +I + G+IVNV S + + SVY ++KG L ++ +A E+ KIRVN V P Sbjct: 129 MI-QQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF 187 Query: 182 VMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 V T M + K + + IPLG+F E V +A++FLL S TG L V+GG Sbjct: 188 VHTDMTKDL-----KEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVDGGL 240 Query: 242 W 242 Sbjct: 241 Q 241 >3UVE-A nrPDB Length = 286 Score = 220 bits (562), Expect = 3e-58, Method: Composition-based stats. Identities = 75/279 (26%), Positives = 118/279 (42%), Gaps = 40/279 (14%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS----------------RTQADL 44 M + G+ VTGA +G GR L GA ++AV T DL Sbjct: 5 MTGRVEGKVAFVTGAARGQGRSHAVRLAQEGADIIAVDICKPIRAGVVDTAIPASTPEDL 64 Query: 45 DSLVRECPG----IEPVCVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLE-V 95 G I VD+ D++A + A+ +G +D++V NA + L+ Sbjct: 65 AETADLVKGHNRRIVTAEVDVRDYDALKAAVDSGVEQLGRLDIIVANAGIGNGGDTLDKT 124 Query: 96 TKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGA 155 ++E + ++NL V + + +IA G G+I+ SS +A + Y + K Sbjct: 125 SEEDWTEMIDINLAGVWKTVKAGVPHMIAGGRGGSIILTSSVGGLKAYPHTGHYVAAKHG 184 Query: 156 LDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQA--------------TWSDPHKAKTML 201 + L + +ELG H IRVN+V+PT V T M D M Sbjct: 185 VVGLMRAFGVELGQHMIRVNSVHPTHVKTPMLHNEGTFKMFRPDLENPGPDDMAPICQMF 244 Query: 202 NRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + +P+ + E + NA+LF SD + TG TLP++ G Sbjct: 245 HTLPI-PWVEPIDISNAVLFFASDEARYITGVTLPIDAG 282 >4IIV-A nrPDB Length = 267 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 63/244 (25%), Positives = 102/244 (41%), Gaps = 12/244 (4%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-----QADLDSLVRECPGIEPVCVDLG 62 R VLVTGA KGIGR + L A G + Q L+++V + D+ Sbjct: 27 RSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNGRLLSFDVA 86 Query: 63 DWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + E E + G +V+NA +A F ++ + +D NL + V Q Sbjct: 87 NREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDSFYNVIQPC 146 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 +I G I+ +SS Y + K + TK +A+EL KI VN + Sbjct: 147 IMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGIIGATKALAIELAKRKITVNCIA 206 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P ++ T M + + K ++ IP+ + + E V +L+SD +G T + + Sbjct: 207 PGLIDTGMIE---MEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISIN 263 Query: 239 GGFW 242 GG Sbjct: 264 GGML 267 >3UF0-A nrPDB Length = 273 Score = 220 bits (561), Expect = 4e-58, Method: Composition-based stats. Identities = 82/248 (33%), Positives = 118/248 (47%), Gaps = 7/248 (2%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT---QADLDSLVRECPGIEPVCV 59 LAGR +VTGAG GIGR GA V+A RT + D + E V Sbjct: 27 FSLAGRTAVVTGAGSGIGRAIAHGYARAGAHVLAWGRTDGVKEVADEIADGGGSAEAVVA 86 Query: 60 DLGDWEATERALGSV---GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 DL D E + VD+LVNNA + P EV+ + VNL A +S+ Sbjct: 87 DLADLEGAANVAEELAATRRVDVLVNNAGIIARAPAEEVSLGRWREVLTVNLDAAWVLSR 146 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 ++A G G IV ++S S + N + Y ++K A+ LT+ +A E + VNA Sbjct: 147 SFGTAMLAHG-SGRIVTIASMLSFQGGRNVAAYAASKHAVVGLTRALASEWAGRGVGVNA 205 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 + P V+T+ A +D +A + RIP G++A E +V +FL SD + G L Sbjct: 206 LAPGYVVTANTAALRADDERAAEITARIPAGRWATPEDMVGPAVFLASDAASYVHGQVLA 265 Query: 237 VEGGFWAC 244 V+GG+ A Sbjct: 266 VDGGWLAS 273 >4RZI-B nrPDB Length = 240 Score = 220 bits (560), Expect = 6e-58, Method: Composition-based stats. Identities = 69/241 (28%), Positives = 106/241 (43%), Gaps = 8/241 (3%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 + L L + ++VTG +GIG V+ L GA+V ++ E G+ D Sbjct: 2 LSLGLEDKVIVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNT---EALGVVANVTD 58 Query: 61 LGDWEATERAL-GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 L A + +GPV +V NA + F ++T +D VNL+ V + Sbjct: 59 LESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAYSIKPFI 118 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 G+ R G+IV +SS +R + Y +TK + + K +A E + +R NAV P Sbjct: 119 EGMYERKA-GSIVAISSISGERGNVGQTNYSATKAGVIGMMKSLAREGARYGVRANAVAP 177 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTGSTLPVE 238 + T M A D + + IP +F + E + A+ FLLS S TG L V Sbjct: 178 GFIDTEMTLAIREDIR--EKITKEIPFRRFGKPEEIAWAVAFLLSPVASSYVTGEVLRVN 235 Query: 239 G 239 G Sbjct: 236 G 236 >1K2W-A nrPDB Length = 256 Score = 219 bits (559), Expect = 7e-58, Method: Composition-based stats. Identities = 78/254 (30%), Positives = 121/254 (47%), Gaps = 14/254 (5%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-PGIEPVCVDL 61 + L G+ L+TG+ +GIGR +A GARV + E P + +D+ Sbjct: 1 MRLDGKTALITGSARGIGRAFAEAYVREGARVAIADINLEAARATAAEIGPAACAIALDV 60 Query: 62 GDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D + +R + G +D+LVNNAA+ L P +E+T+E++DR F +N+ + + Q Sbjct: 61 TDQASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLFMMQA 120 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 VAR +IA G G I+N++SQ +R VYC+TK A+ LT+ L L H I VNA+ Sbjct: 121 VARAMIAGGRGGKIINMASQAGRRGEALVGVYCATKAAVISLTQSAGLNLIRHGINVNAI 180 Query: 178 NPTVVMTSMGQAT---------WSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 P VV K + + +P G+ E + +FL + + Sbjct: 181 APGVVDGEHWDGVDAKFADYENLPRGEKKRQVGAAVPFGRMGRAEDLTGMAIFLATPEAD 240 Query: 229 MTTGSTLPVEGGFW 242 T V+GG W Sbjct: 241 YIVAQTYNVDGGNW 254 >3WTC-A nrPDB Length = 262 Score = 219 bits (558), Expect = 9e-58, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 109/256 (42%), Gaps = 17/256 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVC 58 + L+G+ VTGA +GIG+ L GA V+ + Q L +E + Sbjct: 4 MSLSGKIAAVTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEVEALGRRAVALT 63 Query: 59 VDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ + + L ++G +D++VNNA + ++P L++ ++ F +N++ V+ Sbjct: 64 ADISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLWG 123 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 Q A +G G I+N S Y +TK A+ LT+ A EL I V Sbjct: 124 MQAAATLFKEKGTKGKIINACSIAGHEGYPLLGAYSATKFAVRALTQSAAKELASSGITV 183 Query: 175 NAVNPTVVMTSMGQATWSDPHKA---------KTMLNRIPLGKFAEVEHVVNAILFLLSD 225 N+ P +V T M + K + I LG+ + V + +L S Sbjct: 184 NSYCPGIVGTDMWVTIDKRMAEITGTEIGATYKKYVEGIALGRVETADDVAGFVAYLSSS 243 Query: 226 RSGMTTGSTLPVEGGF 241 + TG ++ ++GG Sbjct: 244 DADYMTGQSVLIDGGL 259 >1NFF-A nrPDB Length = 260 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 76/248 (30%), Positives = 119/248 (47%), Gaps = 13/248 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI-EPVCV 59 M L G+ LV+G +G+G V+A+ A GA+VV + ++ E V + Sbjct: 1 MSGRLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAARYVHL 60 Query: 60 DLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ A + A+ + G + +LVNNA + + + + R +VNL V Sbjct: 61 DVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGI 120 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V + + G G+I+N+SS Y +TK A+ LTK ALELGP IRVN Sbjct: 121 RAVVKPMKEAGR-GSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRVN 179 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 +++P +V T M D + + LG+ AE V N +++L SD S +TG+ Sbjct: 180 SIHPGLVKTPMTDWVPED-------IFQTALGRAAEPVEVSNLVVYLASDESSYSTGAEF 232 Query: 236 PVEGGFWA 243 V+GG A Sbjct: 233 VVDGGTVA 240 >5YSS-A nrPDB Length = 256 Score = 218 bits (557), Expect = 1e-57, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 113/256 (44%), Gaps = 16/256 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ--ADLDSLVRECPGIEPVCVD 60 + L G+ LVTG+ GIG G Q L GA ++ A D++ + D Sbjct: 1 MNLTGKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDVDAAKDAVAQYGKTPGYHGAD 60 Query: 61 LGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 L D + G VD+L+NNA + + P + ++ +NL +V ++ Sbjct: 61 LSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVDKWNAIIAINLSSVFHTTR 120 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + G+ AR G I+N++S A S Y + K + LTK +ALE +I NA Sbjct: 121 LALPGMRARNW-GRIINIASVHGLVASKEKSAYVAAKHGVVGLTKTIALETAQTEITCNA 179 Query: 177 VNPTVVMTSMGQ-------ATWSDPHKAKTML--NRIPLGKFAEVEHVVNAILFLLSDRS 227 + P V+T + Q A ++P A+ L + P +F E + N LFL SD + Sbjct: 180 LCPGWVLTPLVQQQIDKRIAEGAEPEAARDALLAEKQPSREFVTPEQLGNLALFLCSDGA 239 Query: 228 GMTTGSTLPVEGGFWA 243 G ++GG+ A Sbjct: 240 AQVRGVAWNMDGGWVA 255 >3W8F-A nrPDB Length = 260 Score = 217 bits (554), Expect = 3e-57, Method: Composition-based stats. Identities = 72/260 (27%), Positives = 112/260 (43%), Gaps = 21/260 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ----ADLDSLVRECPGIEPVC- 58 L G++ +VTG+ GIG L GA VV Q S + G++ Sbjct: 1 MLKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLESKFGVKAYYL 60 Query: 59 -VDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 DL D +A +A ++G +D+LVNNA + P E + ++ +NL AV Sbjct: 61 NADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIEEFPVDKWNAIIALNLSAVFH 120 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + + +G G I+N++S A N S Y + K + LTKV ALE I Sbjct: 121 GTAAALPIMQKQGW-GRIINIASAHGLVASVNKSAYVAAKHGVVGLTKVTALENAGKGIT 179 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTM----------LNRIPLGKFAEVEHVVNAILFLL 223 NA+ P V T + + + K + + P +F E + A +FL Sbjct: 180 CNAICPGWVRTPLVEKQIEAISQQKGIDIEAAARELLAEKQPSLQFVTPEQLGGAAVFLS 239 Query: 224 SDRSGMTTGSTLPVEGGFWA 243 S + TG+TL ++GG+ A Sbjct: 240 SAAADQMTGTTLSLDGGWTA 259 >4IS3-A nrPDB Length = 268 Score = 217 bits (554), Expect = 3e-57, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 110/251 (43%), Gaps = 14/251 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP---- 56 M L + ++TG +GIG + GA+V TQ ++D+ + + + P Sbjct: 20 MNLV-QDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEV 78 Query: 57 --VCVDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 DL +A A+G V G +D+++NNA + F V++E F ++N+ Sbjct: 79 LGFAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTG 138 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 V + A + G I+N +S + Y ++K ++ LT + E+ Sbjct: 139 VFNGA-WCAYQCMKDAKKGVIINTASVTGIFGSLSGVGYPASKASVIGLTHGLGREIIRK 197 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRV V P VV T M P + L +P+ + E E + N LFL SD + Sbjct: 198 NIRVVGVAPGVVNTDMTNGNP--PEIMEGYLKALPMKRMLEPEEIANVYLFLASDLASGI 255 Query: 231 TGSTLPVEGGF 241 T +T+ V+G + Sbjct: 256 TATTVSVDGAY 266 >3V2G-A nrPDB Length = 271 Score = 217 bits (553), Expect = 4e-57, Method: Composition-based stats. Identities = 76/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-----RTQADLDSLVRECPGIEP 56 + LAG+ VTG +GIG + L GA V R QA + + + Sbjct: 26 SISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRAVA 85 Query: 57 VCVDLGDWEATERA----LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 + D D EA E+A + ++G +D+LVN+A + P E T FD VN RA Sbjct: 86 IRADNRDAEAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFDEVMAVNFRAPF 145 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQR-AVTNHSVYCSTKGALDMLTKVMALELGPHK 171 + +R L G G I+ + S ++ S+Y ++K AL LTK +A +LGP Sbjct: 146 VAIRSASRHL---GDGGRIITIGSNLAELVPWPGISLYSASKAALAGLTKGLARDLGPRG 202 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 I VN V+P T M A D A+ RI G + E + + + +L + T Sbjct: 203 ITVNIVHPGSTDTDMNPA---DGDHAEAQRERIATGSYGEPQDIAGLVAWLAGPQGKFVT 259 Query: 232 GSTLPVEGGFWA 243 G++L ++GG A Sbjct: 260 GASLTIDGGANA 271 >1X1T-A nrPDB Length = 260 Score = 216 bits (551), Expect = 6e-57, Method: Composition-based stats. Identities = 73/260 (28%), Positives = 110/260 (42%), Gaps = 21/260 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE------PV 57 L G+ +VTG+ GIG G AL A GA +V A VR + Sbjct: 1 MLKGKVAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLAAQHGVKVLYD 60 Query: 58 CVDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 DL EA + A+ +G +D+LVNNA + + E +D +NL AV Sbjct: 61 GADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIEDFPTEKWDAILALNLSAVFH 120 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + + +G G I+N++S A N S Y + K + TKV ALE I Sbjct: 121 GTAAALPHMKKQG-FGRIINIASAHGLVASANKSAYVAAKHGVVGFTKVTALETAGQGIT 179 Query: 174 VNAVNPTVVMTSMGQATWS----------DPHKAKTMLNRIPLGKFAEVEHVVNAILFLL 223 NA+ P V T + + S + + + + P +F E + +FL Sbjct: 180 ANAICPGWVRTPLVEKQISALAEKNGVDQETAARELLSEKQPSLQFVTPEQLGGTAVFLA 239 Query: 224 SDRSGMTTGSTLPVEGGFWA 243 SD + TG+T+ V+GG+ A Sbjct: 240 SDAAAQITGTTVSVDGGWTA 259 >3V2H-A nrPDB Length = 281 Score = 216 bits (551), Expect = 7e-57, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 108/256 (42%), Gaps = 21/256 (8%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-LDSLVRECPGIEP-----VCVDL 61 + ++TG+ GIG + L GA +V D + ++ E G+ D+ Sbjct: 26 KTAVITGSTSGIGLAIARTLAKAGANIVLNGFGAPDEIRTVTDEVAGLSSGTVLHHPADM 85 Query: 62 GDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + G D+LVNNA V ++ + E +DR VNL + + Sbjct: 86 TKPSEIADMMAMVADRFGGADILVNNAGVQFVEKIEDFPVEQWDRIIAVNLSSSFHTIRG 145 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 + +G G I+N++S A S Y + K + LTK +ALE+ + VN++ Sbjct: 146 AIPPMKKKGW-GRIINIASAHGLVASPFKSAYVAAKHGIMGLTKTVALEVAESGVTVNSI 204 Query: 178 NPTVVMTSMGQATWSDPHKA----------KTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 P V+T + + D + + ML P KF VE V + L+L D + Sbjct: 205 CPGYVLTPLVEKQIPDQARTRGITEEQVINEVMLKGQPTKKFITVEQVASLALYLAGDDA 264 Query: 228 GMTTGSTLPVEGGFWA 243 TG+ + ++GG+ A Sbjct: 265 AQITGTHVSMDGGWTA 280 >3WYE-A nrPDB Length = 256 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 76/252 (30%), Positives = 115/252 (45%), Gaps = 17/252 (6%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC----PGIEPVCVDLG 62 + LVTGAG+GIG+ L G V A ++ E V VD+ Sbjct: 2 KKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVAVKVDVS 61 Query: 63 DWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D + A E+A ++G D++VNNA +A ++P LEVT+E + + VN+ +V Q Sbjct: 62 DRDQVFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAA 121 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G G I+N +S + + S Y +TK A+ LT+ A +L P I VN Sbjct: 122 VEAFKKEGHGGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQTAARDLAPLGITVNGYC 181 Query: 179 PTVVMTSMGQATWSDPHKA---------KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 P +V T M + ++ K K + I LG+ + E V + FL S S Sbjct: 182 PGIVGTGMWEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASPDSDY 241 Query: 230 TTGSTLPVEGGF 241 TG +L ++GG Sbjct: 242 MTGQSLLIDGGM 253 >3T7C-A nrPDB Length = 299 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 81/275 (29%), Positives = 124/275 (45%), Gaps = 36/275 (13%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLV 48 M + G+ +TGA +G GR L GA ++A+ T DL V Sbjct: 22 MAGKVEGKVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDGVKLPMSTPDDLAETV 81 Query: 49 RECPG----IEPVCVDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFL-EVTKEA 99 R+ I VD+ D++A + A+ +G +D+++ NAA+A L + + Sbjct: 82 RQVEALGRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKT 141 Query: 100 FDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + +VNL +++ ++A G+IV SS R N Y ++K L L Sbjct: 142 WRDMIDVNLNGAWITARVAIPHIMAGKRGGSIVFTSSIGGLRGAENIGNYIASKHGLHGL 201 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMG--------------QATWSDPHKAKTMLNRIP 205 + MALELGP IRVN V P+ V T M T D A ++ +P Sbjct: 202 MRTMALELGPRNIRVNIVCPSSVATPMLLNEPTYRMFRPDLENPTVEDFQVASRQMHVLP 261 Query: 206 LGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + E + NAILFL+SD + TG +LPV+GG Sbjct: 262 I-PYVEPADISNAILFLVSDDARYITGVSLPVDGG 295 >4DBZ-A nrPDB Length = 281 Score = 211 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 70/252 (27%), Positives = 111/252 (44%), Gaps = 20/252 (7%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI----EPVCVDLGDW 64 LVTGA GIG + L G RV +R + L + ++E + D+ Sbjct: 28 VALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGVEADGRTCDVRSV 87 Query: 65 EATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 E + +V GPVD+LVNNA E+ E + E NL V +V++ V + Sbjct: 88 PEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTKQVLK 147 Query: 121 --GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 G++ RG G IVN++S ++ + + + Y ++K + TK + LEL I VNAV Sbjct: 148 AGGMLERGT-GRIVNIASTGGKQGLVHAAPYSASKHGVVGFTKALGLELARTGITVNAVC 206 Query: 179 PTVVMTSMGQATW---------SDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 P V T M + S + R+P+G++ + V + +L+ + Sbjct: 207 PGFVETPMAASVREHYSDIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAA 266 Query: 230 TTGSTLPVEGGF 241 T L V GG Sbjct: 267 VTAQALNVCGGL 278 >4E6P-A nrPDB Length = 259 Score = 211 bits (538), Expect = 2e-55, Method: Composition-based stats. Identities = 76/256 (29%), Positives = 121/256 (47%), Gaps = 14/256 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-PGIEPVCV 59 M L G+ L+TG+ +GIGR +A GA V E P V + Sbjct: 2 MMKRLEGKSALITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEIGPAAYAVQM 61 Query: 60 DLGDWEATERA----LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ ++ + A + G +D+LVNNAA+ L P +E+T+E++++ F +N+ + Sbjct: 62 DVTRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFTL 121 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 Q AR +IA+G G I+N++SQ +R ++YC+TK A+ LT+ L+L H+I VN Sbjct: 122 QAAARQMIAQGRGGKIINMASQAGRRGEALVAIYCATKAAVISLTQSAGLDLIKHRINVN 181 Query: 176 AVNPTVVMTSMGQAT---------WSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDR 226 A+ P VV K + + +P G+ E + +FL S Sbjct: 182 AIAPGVVDGEHWDGVDALFARYENRPRGEKKRLVGEAVPFGRMGTAEDLTGMAIFLASAE 241 Query: 227 SGMTTGSTLPVEGGFW 242 S T V+GG W Sbjct: 242 SDYIVSQTYNVDGGNW 257 >2AG5-A nrPDB Length = 246 Score = 211 bits (538), Expect = 2e-55, Method: Composition-based stats. Identities = 69/243 (28%), Positives = 118/243 (48%), Gaps = 7/243 (2%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G+ +++T A +GIG+ A GA+V+A ++ L L + PGI+ +D+ Sbjct: 3 RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL-EKYPGIQTRVLDVTK 61 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + ++ V +D+L N A L+ ++ +D S +N+R++ + + ++ Sbjct: 62 KKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKML 121 Query: 124 ARGVPGAIVNVSSQCS-QRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182 A+ G I+N+SS S + V N VY +TK A+ LTK +A + IR N V P V Sbjct: 122 AQ-KSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV 180 Query: 183 MTSMG----QATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 T QA + L R G+FA E + ++L SD S TG+ + ++ Sbjct: 181 DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID 240 Query: 239 GGF 241 GG+ Sbjct: 241 GGW 243 >1AHH-A nrPDB Length = 255 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 72/247 (29%), Positives = 119/247 (48%), Gaps = 11/247 (4%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP--GIEPVCV 59 L L G+ ++TGAG GIG+ GA VV + +V E G + Sbjct: 6 NLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFAC 65 Query: 60 --DLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ + + A+ +G VD+LVNNA +PF ++ F R++E+N+ + Sbjct: 66 RCDITSEQELSALADFAISKLGKVDILVNNAGGGGPKPF-DMPMADFRRAYELNVFSFFH 124 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 +SQ+VA + G G I+ ++S ++ N + Y S+K A L + MA +LG IR Sbjct: 125 LSQLVAPEMEKNG-GGVILTITSMAAENKNINMTSYASSKAAASHLVRNMAFDLGEKNIR 183 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VN + P ++T ++ + P + ML P+ + + + + NA LFL S + +G Sbjct: 184 VNGIAPGAILTDALKSVIT-PEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQ 242 Query: 234 TLPVEGG 240 L V GG Sbjct: 243 ILTVSGG 249 >2CFC-A nrPDB Length = 250 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 108/249 (43%), Gaps = 13/249 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP-----VCVDLG 62 R +VTGA G G A G RV A+ + L+ R V D+ Sbjct: 3 RVAIVTGASSGNGLAIATRFLARGDRVAALDLSAETLEETARTHWHAYADKVLRVRADVA 62 Query: 63 DW----EATERALGSVGPVDLLVNNAAVA---LLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D A + G +D+LVNNA + E FD+ VN+R + Sbjct: 63 DEGDVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLHTTPVEQFDKVMAVNVRGIFLGC 122 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + V ++ +G G IVN++S S A S Y ++KGA+ LTK +A++ IR N Sbjct: 123 RAVLPHMLLQGA-GVIVNIASVASLVAFPGRSAYTTSKGAVLQLTKSVAVDYAGSGIRCN 181 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 AV P ++ T M Q P +L RIP + V +A++FL + + G+ L Sbjct: 182 AVCPGMIETPMTQWRLDQPELRDQVLARIPQKEIGTAAQVADAVMFLAGEDATYVNGAAL 241 Query: 236 PVEGGFWAC 244 ++G + A Sbjct: 242 VMDGAYTAI 250 >2B4Q-A nrPDB Length = 276 Score = 209 bits (533), Expect = 9e-55, Method: Composition-based stats. Identities = 62/251 (24%), Positives = 105/251 (41%), Gaps = 11/251 (4%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI---EPVCV 59 LAGR LVTG +GIG+ Q L GARV +R + + Sbjct: 25 FSLAGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQAIPA 84 Query: 60 DLGDWEATERALGSVG----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 DL R ++G +D+LVNNA + +++ ++N+ +V Sbjct: 85 DLSSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFSCI 144 Query: 116 QIVARGL---IARGVPGAIVNVSSQCSQRAVTNHS-VYCSTKGALDMLTKVMALELGPHK 171 Q + L + P ++N+ S A+ + Y +K AL L++++A EL Sbjct: 145 QQLLPLLRRSASAENPARVINIGSVAGISAMGEQAYAYGPSKAALHQLSRMLAKELVGEH 204 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 I VN + P + M + +DP + IP+G++ E + + L T Sbjct: 205 INVNVIAPGRFPSRMTRHIANDPQALEADSASIPMGRWGRPEEMAALAISLAGTAGAYMT 264 Query: 232 GSTLPVEGGFW 242 G+ +P++GGF Sbjct: 265 GNVIPIDGGFH 275 >5B1Y-A nrPDB Length = 270 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 76/243 (31%), Positives = 114/243 (46%), Gaps = 13/243 (5%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE------CPGIEPVCVDLGD 63 LVTG +GIGR TV G VV +++ADL E P V VD+GD Sbjct: 26 ALVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLGSPEAYTVRVDVGD 85 Query: 64 WEATERALGSVG----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 ++ VG +++LVN A V L E + ++ + VNL V V++++ Sbjct: 86 PDSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVYLVTKLLL 145 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVT-NHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 + + +IVNV+S + Y ++K + LTK +A++L + IRVNAV Sbjct: 146 PL-LRKAKWASIVNVASIAGETGNVVAGVAYSASKAGVIGLTKRLAVQLAGYGIRVNAVA 204 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD-RSGMTTGSTLPV 237 P+ V T M ++ P K + + + PL + E V AILFL RS TG L + Sbjct: 205 PSFVETDMTRSFLDTPEKRERIASLHPLKIILKPEDVAEAILFLADPRRSRGITGHVLSI 264 Query: 238 EGG 240 G Sbjct: 265 NAG 267 >3RWB-A nrPDB Length = 247 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 63/243 (25%), Positives = 111/243 (45%), Gaps = 6/243 (2%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPVCVDLG 62 LAG+ LVTGA +GIG+ L A GA V+ + + D+ Sbjct: 3 RLAGKTALVTGAAQGIGKAIAARLAADGATVIVSDINAEGAKAAAASIGKKARAIAADIS 62 Query: 63 DWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D + + + G +D+LVNNA++ + +V + + + +VNL V++ Sbjct: 63 DPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRAG 122 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 + A G G +++++S N + Y + KG + T+ +A ELG + I NAV Sbjct: 123 TDQMRAAGKAGRVISIASNTFFAGTPNMAAYVAAKGGVIGFTRALATELGKYNITANAVT 182 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 P ++ + +A+ + + + GK + EH+ + + FL SD + TG TL V+ Sbjct: 183 PGLIESDGVKASPHNEAFGFVEMLQAMKGK-GQPEHIADVVSFLASDDARWITGQTLNVD 241 Query: 239 GGF 241 G Sbjct: 242 AGM 244 >4EGF-A nrPDB Length = 266 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 101/249 (40%), Positives = 147/249 (59%), Gaps = 9/249 (3%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPV 57 L L G+R L+TGA KGIG +A A GAR+V R ++LD+ R + V Sbjct: 16 LRLDGKRALITGATKGIGADIARAFAAAGARLVLSGRDVSELDAARRALGEQFGTDVHTV 75 Query: 58 CVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 +DL + +A RA + G +D+LVNNA ++ QP ++ + FD + VNLRA Sbjct: 76 AIDLAEPDAPAELARRAAEAFGGLDVLVNNAGISHPQPVVDTDPQLFDATIAVNLRAPAL 135 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ V + ++A G GAI+ V+S + + +H YC++K L M TKV+A ELGPH IR Sbjct: 136 LASAVGKAMVAAGEGGAIITVASAAALAPLPDHYAYCTSKAGLVMATKVLARELGPHGIR 195 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N+V PTVV+T MGQ W D K+ M+ RIPLG+FA V +A+++L SD + M G Sbjct: 196 ANSVCPTVVLTEMGQRVWGDEAKSAPMIARIPLGRFAVPHEVSDAVVWLASDAASMINGV 255 Query: 234 TLPVEGGFW 242 +PV+GG+ Sbjct: 256 DIPVDGGYT 264 >5EJ2-A nrPDB Length = 308 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 74/275 (26%), Positives = 119/275 (43%), Gaps = 36/275 (13%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLV 48 M +AG+ ++GA +G GR L GA ++A+ T DL Sbjct: 31 MTGRVAGKVAFISGAARGQGRSHAVRLAQEGADIIAIDICGPIENLAYPHSTPEDLAETA 90 Query: 49 RECPGIE----PVCVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQP-FLEVTKEA 99 ++ VD+ D+EA + + +G +D++V NA V ++ Sbjct: 91 DLVKDLDRRIVTAQVDVRDFEALKSAVDSGVEQLGRLDIIVANAGVGTDGRKLHKIRDNV 150 Query: 100 FDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + ++NL V + +++ G G+IV SS ++A N Y + K + L Sbjct: 151 WQDMIDINLTGVWHTVKAGVPHVLSGGRGGSIVLTSSVGGRKAYPNTGHYIAAKHGVIGL 210 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMG--------------QATWSDPHKAKTMLNRIP 205 + A+ELGPH IRVNAV PT V T+M D M++ +P Sbjct: 211 MRAFAVELGPHMIRVNAVLPTQVSTTMVMNDQTFRLFRPDLENPGPDDFAPISQMMHTLP 270 Query: 206 LGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + + + NA+LFL SD S TG +LPV+ G Sbjct: 271 V-PWVDASDISNAVLFLASDESRYVTGVSLPVDAG 304 >3R3S-A nrPDB Length = 294 Score = 207 bits (528), Expect = 3e-54, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 100/248 (40%), Gaps = 14/248 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS-----LVRECPG-IEPV 57 L R+ LVTG GIGR A GA V + D+ L+ EC + Sbjct: 46 RLKDRKALVTGGDSGIGRAAAIAYAREGADVAINYLPAEEEDAQQVKALIEECGRKAVLL 105 Query: 58 CVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQP-FLEVTKEAFDRSFEVNLRAVI 112 DL D + ++G +D+L A P ++T E F ++F VN+ A+ Sbjct: 106 PGDLSDESFARSLVHKAREALGGLDILALVAGKQTAIPEIKDLTSEQFQQTFAVNVFALF 165 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 ++Q L +I+ SS + + + Y +TK A+ ++ +A ++ I Sbjct: 166 WITQEAIPLLPK---GASIITTSSIQAYQPSPHLLDYAATKAAILNYSRGLAKQVAEKGI 222 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 RVN V P + T++ + K + P+ + + + ++L S S T Sbjct: 223 RVNIVAPGPIWTALQISGGQTQDKIPQFGQQTPMKRAGQPAELAPVYVYLASQESSYVTA 282 Query: 233 STLPVEGG 240 V GG Sbjct: 283 EVHGVCGG 290 >2P91-A nrPDB Length = 285 Score = 207 bits (527), Expect = 4e-54, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 115/252 (45%), Gaps = 15/252 (5%) Query: 4 FLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRT---QADLDSLVRECPGIEPVC 58 L G+R L+TG + I G ++ H GA++ T + + + + V Sbjct: 18 LLEGKRALITGVANERSIAYGIAKSFHREGAQLAFTYATPKLEKRVREIAKGFGSDLVVK 77 Query: 59 VDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRA 110 D+ E + + G +D++V++ A A + F ++ ++E F + ++++ + Sbjct: 78 CDVSLDEDIKNLKKFLEENWGSLDIIVHSIAYAPKEEFKGGVIDTSREGFKIAMDISVYS 137 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 +I +++ + + G GAIV +S +++ V +++V K AL+ + +A ++ H Sbjct: 138 LIALTRELLPLM--EGRNGAIVTLSYYGAEKVVPHYNVMGIAKAALESTVRYLAYDIAKH 195 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 R+NA++ V T + + P GK +E V + +FL SD + Sbjct: 196 GHRINAISAGPVKTLAAYSITGFHLLMEHTTKVNPFGKPITIEDVGDTAVFLCSDWARAI 255 Query: 231 TGSTLPVEGGFW 242 TG + V+ G+ Sbjct: 256 TGEVVHVDNGYH 267 >3OIC-A nrPDB Length = 258 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 67/244 (27%), Positives = 127/244 (52%), Gaps = 10/244 (4%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECP--GIEPVCV--D 60 + LVTG+ +G+G+ L G +V R++ E G++ + V + Sbjct: 3 QNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKAN 62 Query: 61 LGDW----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 +G E ++ + G +D+ VNNAA +L+P +E+ + +D + +N +A++ +Q Sbjct: 63 VGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQ 122 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 A+ L+ + G IV++SS S R + N++ +K AL+ LT+ +A+EL P +I VNA Sbjct: 123 EAAK-LMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAALEALTRYLAVELSPKQIIVNA 181 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 V+ + T + + + P G+ E++ +V+ + FL+S ++ M G T+ Sbjct: 182 VSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIKDMVDTVEFLVSSKADMIRGQTII 241 Query: 237 VEGG 240 V+GG Sbjct: 242 VDGG 245 >4FC7-A nrPDB Length = 277 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 63/249 (25%), Positives = 108/249 (43%), Gaps = 11/249 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-----PVC 58 L + +TG G GIG + G V SR+ + + R+ G P+ Sbjct: 24 LLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLS 83 Query: 59 VDL----GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +D+ A ++AL G +D+L+N AA L P ++ AF +++ V Sbjct: 84 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 143 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S+++ R G IVN+++ R S K A+D +T+ +A+E GP IRV Sbjct: 144 SRVLYEKFF-RDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRV 202 Query: 175 NAVNPTVV-MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 N++ P + T + T + PL + + +++L+L S + TG+ Sbjct: 203 NSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGA 262 Query: 234 TLPVEGGFW 242 L +GG W Sbjct: 263 VLVADGGAW 271 >2FWM-X nrPDB Length = 250 Score = 204 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 72/250 (28%), Positives = 107/250 (42%), Gaps = 19/250 (7%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + +G+ V VTGAGKGIG T A GA+V + +E +D+ Sbjct: 3 MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFD------QAFTQEQYPFATEVMDVA 56 Query: 63 DWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D +R L +D LVN A + + +++KE + ++F VN+ + Q Sbjct: 57 DAAQVAQVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQT 116 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 R GAIV V+S + S Y ++K AL L + LEL +R N V+ Sbjct: 117 MNQF-RRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVS 175 Query: 179 PTVVMTSMGQATWSDPHKAKTMLN--------RIPLGKFAEVEHVVNAILFLLSDRSGMT 230 P T M + W + + IPLGK A + + N ILFL SD + Sbjct: 176 PGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHI 235 Query: 231 TGSTLPVEGG 240 T + V+GG Sbjct: 236 TLQDIVVDGG 245 >4MOW-A nrPDB Length = 256 Score = 204 bits (520), Expect = 2e-53, Method: Composition-based stats. Identities = 82/247 (33%), Positives = 123/247 (49%), Gaps = 13/247 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ-----ADLDSLVRECPGIEPVCV 59 LAG+ +VTGA KGIG +AL GA VV + A + ++ V Sbjct: 12 LAGKVAIVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGGRAVAVGG 71 Query: 60 DLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ + A+ + G +D+LVNN+ V P +T+E + R F+ N+ V+ + Sbjct: 72 DVSKAADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITEEHYRRQFDTNVFGVLLTT 131 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 Q + L G +I+N+SS + +VY TKGA+D +T V+ALELGP KIRVN Sbjct: 132 QAAVKHL---GEGASIINISSVVTSITPPASAVYSGTKGAVDAITGVLALELGPRKIRVN 188 Query: 176 AVNPTVVMTSMGQ-ATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234 A+NP +++T A +L + PLG+ E + + +FL SD + TG Sbjct: 189 AINPGMIVTEGTHSAGIIGSDLEAQVLGQTPLGRLGEPNDIASVAVFLASDDARWMTGEH 248 Query: 235 LPVEGGF 241 L V GG Sbjct: 249 LVVSGGL 255 >2HSD-A nrPDB Length = 253 Score = 202 bits (514), Expect = 1e-52, Method: Composition-based stats. Identities = 73/243 (30%), Positives = 116/243 (47%), Gaps = 8/243 (3%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-PGIEPVCVDLGD 63 L+G+ V++TG +G+G + A GARVV + + RE +D+ Sbjct: 3 LSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLDVTI 62 Query: 64 WEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 E +R + G VD LVNNA ++ + E F + E+NL V + V Sbjct: 63 EEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVI 122 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 + G G+IVN+SS + S Y ++K + L+K+ A+ELG +IRVN+V+P Sbjct: 123 PAMKDAG-GGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSVHP 181 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 + T M T + + P+G+ E + A++ LLSD S TG+ L V+G Sbjct: 182 GMTYTPMTAETG--IRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDG 239 Query: 240 GFW 242 G+ Sbjct: 240 GWT 242 >3U5T-A nrPDB Length = 267 Score = 201 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 66/249 (26%), Positives = 99/249 (39%), Gaps = 13/249 (5%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---ECPGIEPV- 57 + + +VTGA +GIG L + G VV +A V E G + + Sbjct: 22 SMMETNKVAIVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEAAGGKALT 81 Query: 58 -CVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 D+ D A R + G VD+LVNNA + L E FDR VNL+ Sbjct: 82 AQADVSDPAAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTF 141 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + A+ L V G I+N+S+ ++ +Y + K ++ +T V++ EL I Sbjct: 142 NTLREAAQRL---RVGGRIINMSTSQVGLLHPSYGIYAAAKAGVEAMTHVLSKELRGRDI 198 Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 VNAV P T + SD + PL + + + A+ FL G Sbjct: 199 TVNAVAPGPTATDLFLEGKSDEVR-DRFAKLAPLERLGTPQDIAGAVAFLAGPDGAWVNG 257 Query: 233 STLPVEGGF 241 L GG Sbjct: 258 QVLRANGGI 266 >3A28-C nrPDB Length = 258 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 75/254 (29%), Positives = 117/254 (46%), Gaps = 19/254 (7%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVS--RTQADLDSLVRECPGIE----PVCVDL 61 + +VTG +GIGRG + L A G + + + ++ + V +D+ Sbjct: 3 KVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGLDV 62 Query: 62 GDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D A + A +G D+LVNNA +A ++P LEVT+E + + VN+ +V Q Sbjct: 63 TDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQA 122 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 +R GV G I+N +S + + S Y +TK A+ LT+ A EL P VNA Sbjct: 123 ASRKFDELGVKGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGHTVNAY 182 Query: 178 NPTVVMTSMGQATWSDPHKA---------KTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 P +V T M + ++ K K + I LG+ + E V + FL S+ S Sbjct: 183 APGIVGTGMWEQIDAELSKINGKPIGENFKEYSSSIALGRPSVPEDVAGLVSFLASENSN 242 Query: 229 MTTGSTLPVEGGFW 242 TG + V+GG Sbjct: 243 YVTGQVMLVDGGML 256 >5TF4-A nrPDB Length = 274 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 112/251 (44%), Gaps = 16/251 (6%) Query: 4 FLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 L G+R L+ G + I G + + GA + + +A ++ L E G Sbjct: 9 LLYGKRGLILGLANNRSIAWGIAKTASSAGAELAFTYQGEAMKKRVEPLAEEVKGFVCGH 68 Query: 59 VDLGDWEATERAL----GSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLRA 110 D+ D + + G +D LV+ + L ++++++ F + +++ + Sbjct: 69 CDVSDSASIDAVFNTIEKKWGKLDFLVHAIGFSDKEELSGRYVDISESNFMMTMNISVYS 128 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + +++ + + G+I+ ++ +++ V N++V K AL+ K +A++LGP Sbjct: 129 LTALTKRAEKLM---SDGGSILTLTYYGAEKVVPNYNVMGVAKAALEASVKYLAVDLGPK 185 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRVNA++ + T + K PL + +E V ++ L+LLSD S Sbjct: 186 HIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIEEVGDSALYLLSDLSRSV 245 Query: 231 TGSTLPVEGGF 241 TG V+ G+ Sbjct: 246 TGEVHHVDSGY 256 >3OIG-A nrPDB Length = 266 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 105/258 (40%), Gaps = 20/258 (7%) Query: 1 MELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----- 53 M L GR ++V G + I G ++LH GAR++ L+ V E G Sbjct: 1 MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAG-ERLEKSVHELAGTLDRN 59 Query: 54 -IEPVCVDLGDWEATERAL----GSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSF 104 + D+ + E VG + + + A A L+ +L ++ F + Sbjct: 60 DSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAH 119 Query: 105 EVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164 ++ ++ V + + G+IV ++ + + N++V K +LD K +A Sbjct: 120 NISSYSLTAVVKAARPMM---TEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLA 176 Query: 165 LELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 +LG IRVN+++ + T + K + R PL + E V + FL S Sbjct: 177 ADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFS 236 Query: 225 DRSGMTTGSTLPVEGGFW 242 D S TG L V+ GF Sbjct: 237 DMSRGITGENLHVDSGFH 254 >3UN1-A nrPDB Length = 260 Score = 198 bits (505), Expect = 1e-51, Method: Composition-based stats. Identities = 78/247 (31%), Positives = 127/247 (51%), Gaps = 19/247 (7%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + + V++TGA +GIG G V+A RVVA SR+ P I V D+ Sbjct: 24 MRNQQKVVVITGASQGIGAGLVRAYRDRNYRVVATSRSIKPSAD-----PDIHTVAGDIS 78 Query: 63 DWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 E +R + G +D LVNNA V L +PF+E+T+E +D + VN+ ++Q Sbjct: 79 KPETADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFHITQRA 138 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCST--KGALDMLTKVMALELGPHKIRVNA 176 A ++ +G G IV++++ + + ++ KG L+ +T+ +A+E +RVNA Sbjct: 139 AAEMLKQG-SGHIVSITTSLVDQPMVGMPSALASLTKGGLNAVTRSLAMEFSRSGVRVNA 197 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLP 236 V+P V+ T M A T+ P+G+ E+ VV+A+L+L + +G TG L Sbjct: 198 VSPGVIKTPMHPA-----ETHSTLAGLHPVGRMGEIRDVVDAVLYL--EHAGFITGEILH 250 Query: 237 VEGGFWA 243 V+GG A Sbjct: 251 VDGGQNA 257 >1DOH-A nrPDB Length = 283 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 67/258 (25%), Positives = 114/258 (44%), Gaps = 24/258 (9%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-----QADLDSLVRECPGIEPVC 58 L G+ LVTGAG+GIGR L G +V+ + + ++ + V Sbjct: 26 SLEGKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVK 85 Query: 59 VDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 ++G E E A+ G +D++ +N+ V +VT E FDR F +N R V Sbjct: 86 ANVGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFV 145 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQ-RAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ + L + G ++ + S Q +AV H+VY +KGA++ + MA+++ KI Sbjct: 146 AREAYKHL---EIGGRLILMGSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKIT 202 Query: 174 VNAVNPTVVMTSM-----------GQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFL 222 VN V P + T M G+ ++ + PL + + + FL Sbjct: 203 VNVVAPGGIKTDMYHAVCREYIPNGENLSNEEVDEYAAVQWSPLRRVGLPIDIARVVCFL 262 Query: 223 LSDRSGMTTGSTLPVEGG 240 S+ G TG + ++GG Sbjct: 263 ASNDGGWVTGKVIGIDGG 280 >2YW9-A nrPDB Length = 261 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 105/251 (41%), Gaps = 16/251 (6%) Query: 5 LAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVS---RTQADLDSLVRECPGIEPVCV 59 L+G++ LV G + +G L GA V R + + + L G Sbjct: 6 LSGKKALVMGVTNQRSLGFAIAAKLKEAGAEVALSYQAERLRPEAEKLAEALGGALLFRA 65 Query: 60 DLGDWEATERAL----GSVGPVDLLVNNAAVALL----QPFLEVTKEAFDRSFEVNLRAV 111 D+ E + + G +D LV+ A A +++ ++ + + EV+ ++ Sbjct: 66 DVTQDEELDALFAGVKEAFGGLDYLVHAIAFAPREAMEGRYIDTRRQDWLLALEVSAYSL 125 Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 + V++ L G IV ++ S++ V ++V K AL+ + +A ELGP Sbjct: 126 VAVARRAEPLL---REGGGIVTLTYYASEKVVPKYNVMAIAKAALEASVRYLAYELGPKG 182 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231 +RVNA++ V T ++ + PL + E V N LFLLS + T Sbjct: 183 VRVNAISAGPVRTVAARSIPGFTKMYDRVAQTAPLRRNITQEEVGNLGLFLLSPLASGIT 242 Query: 232 GSTLPVEGGFW 242 G + V+ G+ Sbjct: 243 GEVVYVDAGYH 253 >3GRK-A nrPDB Length = 293 Score = 195 bits (496), Expect = 1e-50, Method: Composition-based stats. Identities = 53/252 (21%), Positives = 107/252 (42%), Gaps = 16/252 (6%) Query: 4 FLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 L G+R L+ G + I G +A GA + + A ++ L E Sbjct: 28 LLQGKRGLILGVANNRSIAWGIAKAAREAGAELAFTYQGDALKKRVEPLAEELGAFVAGH 87 Query: 59 VDLGDWEATERALGS----VGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLRA 110 D+ D + + + G +D LV+ + L +++ ++ F + +++ + Sbjct: 88 CDVADAASIDAVFETLEKKWGKLDFLVHAIGFSDKDELTGRYIDTSEANFTNTMLISVYS 147 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 + VS+ + + G+I+ ++ +++ + N++V K AL+ K +A++LGP Sbjct: 148 LTAVSRRAEKLM---ADGGSILTLTYYGAEKVMPNYNVMGVAKAALEASVKYLAVDLGPQ 204 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRVNA++ + T + K PL + ++ V + L+ LSD S Sbjct: 205 NIRVNAISAGPIKTLAASGIGDFRYILKWNEYNAPLRRTVTIDEVGDVGLYFLSDLSRSV 264 Query: 231 TGSTLPVEGGFW 242 TG + G+ Sbjct: 265 TGEVHHADSGYH 276 >5YCX-A nrPDB Length = 266 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 113/257 (43%), Gaps = 19/257 (7%) Query: 1 MELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVS---RTQADLDSLVRECPGIE 55 MEL L G+ +V G + I G ++LH GA+++ R + ++ L G E Sbjct: 3 MEL-LQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAGERLERNVRELADTLEGQE 61 Query: 56 PVC--VDLGDWEATERALG----SVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFE 105 + D+ + E VG + + + A A L F++ +++ F + Sbjct: 62 SLVLPCDVTNDEELTACFETIKQEVGTIHGVAHCIAFANRDDLKGEFVDTSRDGFLLAQN 121 Query: 106 VNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMAL 165 ++ ++ V++ + + G I+ ++ +R V N++V K +L+ K +A Sbjct: 122 ISAFSLTAVAREAKKVM---TEGGNILTLTYLGGERVVKNYNVMGVAKASLEASVKYLAN 178 Query: 166 ELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 +LG H IRVNA++ + T + + + R PL + E V + +FL SD Sbjct: 179 DLGQHGIRVNAISAGPIRTLSAKGVGDFNSILREIEERAPLRRTTTQEEVGDTAVFLFSD 238 Query: 226 RSGMTTGSTLPVEGGFW 242 + TG + V+ G+ Sbjct: 239 LARGVTGENIHVDSGYH 255 >1H5Q-A nrPDB Length = 265 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 70/254 (27%), Positives = 115/254 (45%), Gaps = 18/254 (7%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPV 57 + + ++VTG +GIG +A+ A GA V + R+ AD + + + Sbjct: 10 ISFVNKTIIVTGGNRGIGLAFTRAVAAAGANVAVIYRSAADAVEVTEKVGKEFGVKTKAY 69 Query: 58 CVDLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 D+ + + ++ +GP+ L+ NA V++++P E+T E F ++VN+ V Sbjct: 70 QCDVSNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVFN 129 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQR-------AVTNHSVYCSTKGALDMLTKVMALE 166 + VA+ + + G+IV SS SQ Y S+K A L K +A E Sbjct: 130 TCRAVAKLWLQKQQKGSIVVTSSMSSQIINQSSLNGSLTQVFYNSSKAACSNLVKGLAAE 189 Query: 167 LGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDR 226 IRVNA++P V T Q D + IPL +FA+ E + + LLSD Sbjct: 190 WASAGIRVNALSPGYVNTD--QTAHMDKKIRDHQASNIPLNRFAQPEEMTGQAILLLSDH 247 Query: 227 SGMTTGSTLPVEGG 240 + TG ++GG Sbjct: 248 ATYMTGGEYFIDGG 261 >3U4C-A nrPDB Length = 281 Score = 193 bits (492), Expect = 4e-50, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 96/255 (37%), Gaps = 20/255 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP------VC 58 ++ R V GA +GIG+ L +V SR +++S+ + P + Sbjct: 21 MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVKEDILAKHPEASVIVLA 80 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ D + G +D+L+NN F E +F A I Sbjct: 81 GDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCNIEDMTATFTQKTVAYIDA 140 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 + + L+ + G I+N+ + N AL +K ++++L PH I V Sbjct: 141 IKRAS-SLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAALINASKNISIQLAPHNITV 199 Query: 175 NAVNPTVVMTS---------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 N +NP + T M + + S + + + IP+ + E FL S+ Sbjct: 200 NCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGIPMKRVGSAEETAALAAFLASE 259 Query: 226 RSGMTTGSTLPVEGG 240 + TG + +GG Sbjct: 260 EASYITGQQISADGG 274 >4ZJU-A nrPDB Length = 275 Score = 193 bits (490), Expect = 8e-50, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 104/252 (41%), Gaps = 16/252 (6%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 LAG+R L+ G I G QALH GA + + +D + Sbjct: 13 LLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEFAEQFGSKLVFP 72 Query: 59 VDLGDWEATERALGS----VGPVDLLVNNAAVAL----LQPFLEVT-KEAFDRSFEVNLR 109 D+ + A VD +V++ A F +VT ++ F + +++ Sbjct: 73 CDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISAY 132 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + +++ L AR G ++ ++ Q S+R + N++V K +L+ + +A LG Sbjct: 133 SFVAMARAAKPLLQARQ--GCLLTLTYQGSERVMPNYNVMGMAKASLEAGVRYLASSLGV 190 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 IRVNA++ + T S PL + +E V NA LFL S + Sbjct: 191 DGIRVNAISAGPIRTLAASGIKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASG 250 Query: 230 TTGSTLPVEGGF 241 TG L V+ GF Sbjct: 251 ITGEILYVDAGF 262 >4M89-A nrPDB Length = 261 Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 108/252 (42%), Gaps = 16/252 (6%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAV---SRTQADLDSLVRECPGIEPVC 58 FL G+++L+TG + + I G +A GA + + + + + E Sbjct: 3 FLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFR 62 Query: 59 VDLGDWEATERALGSVG----PVDLLVNNAAVAL----LQPFLE-VTKEAFDRSFEVNLR 109 D+ + + +G +D LV++ A FL+ +++EAF+ + E++ Sbjct: 63 CDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAY 122 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 ++ +++ + RG AIV +S + RA+ N++V K +L+ + A LG Sbjct: 123 SLPALAKAARP--MMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGK 180 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 IR N ++ + T + PL + +E V N FLLSD S Sbjct: 181 EGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSG 240 Query: 230 TTGSTLPVEGGF 241 TG V+GG+ Sbjct: 241 ITGEITYVDGGY 252 >4GKB-A nrPDB Length = 258 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 89/254 (35%), Positives = 129/254 (50%), Gaps = 15/254 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD---LDSLVRECPGIEPV 57 M+L L + V+VTG GIG L A V +R D LD+L + P + Sbjct: 1 MDLNLQDKVVIVTGGASGIGGAISMRLAEERAIPVVFARHAPDGAFLDALAQRQPRATYL 60 Query: 58 CVDLGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQ 113 V+L D +A + + + G +D LVNNA V L+ ++AF S E NL Sbjct: 61 PVELQDDAQCRDAVAQTIATFGRLDGLVNNAGVN-DGIGLDAGRDAFVASLERNLIHYYA 119 Query: 114 VSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 ++ L A GAIVN+SS+ + N S YC++KGA LT+ A+ L H +R Sbjct: 120 MAHYCVPHLKA--TRGAIVNISSKTAVTGQGNTSGYCASKGAQLALTREWAVALREHGVR 177 Query: 174 VNAVNPTVVMTSMGQ---ATWSDPH-KAKTMLNRIPLG-KFAEVEHVVNAILFLLSDRSG 228 VNAV P VMT + + AT+ DP K + ++PLG +F + + + +FLLS R+ Sbjct: 178 VNAVIPAEVMTPLYRNWIATFEDPEAKLAEIAAKVPLGRRFTTPDEIADTAVFLLSPRAS 237 Query: 229 MTTGSTLPVEGGFW 242 TTG L V+GG+ Sbjct: 238 HTTGEWLFVDGGYT 251 >5KOI-A nrPDB Length = 293 Score = 192 bits (488), Expect = 1e-49, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 104/255 (40%), Gaps = 17/255 (6%) Query: 1 MELFLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIE 55 ME + G+R L+ G + G + L A GA + + A + L + Sbjct: 22 MEGLMQGKRGLIMGVANNHSLAWGIAKQLAAQGAELAFTYQGDALGKRVKPLAEQVGSDF 81 Query: 56 PVCVDLGDWEATERALGS----VGPVDLLVNNAAVALLQPF-----LEVTKEAFDRSFEV 106 + D+ D + G +D LV+ + T+E F R+ + Sbjct: 82 VLPCDVEDIATVDAVFEEIEKKWGGLDFLVHAIGFSDKTELKGRYADVTTRENFSRTMVI 141 Query: 107 NLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALE 166 + + +V+Q + + G+I+ ++ S R + N++V K AL+ + + +A + Sbjct: 142 SAYSFTEVAQRAEKLMK---DGGSILTLTYGGSTRTIPNYNVMGVAKAALEAMVRYLAAD 198 Query: 167 LGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDR 226 GP IRVNA++ V T G PL + +++ V + ++LLSD Sbjct: 199 YGPQGIRVNAISAGPVRTLAGAGIGDARAIFSYQRRNSPLRRTVDIDDVGKSAVYLLSDL 258 Query: 227 SGMTTGSTLPVEGGF 241 S TG V+ G+ Sbjct: 259 SSGVTGEIHFVDSGY 273 >4CR6-A nrPDB Length = 271 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 82/250 (32%), Positives = 124/250 (49%), Gaps = 11/250 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 LAG+ +VTGA GIGR TV+A GA VVA+ L + E PG P+ DL D Sbjct: 12 RLAGKAAIVTGAAGGIGRATVEAYLREGASVVAMD-LAPRLAATRYEEPGAIPIACDLAD 70 Query: 64 WEATERALG----SVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 A + A+ +G +D+LV A+ FL+++ +DR +VN+ + Sbjct: 71 RAAIDAAMADAVARLGGLDILVAGGALKGGTGNFLDLSDADWDRYVDVNMTGTFLTCRAG 130 Query: 119 ARGLI-----ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 AR ++ G I+ + S S A + Y + KG + MLT+ MA++L H I Sbjct: 131 ARAMVAAGAGKDGRSARIITIGSVNSFMAEPEAAAYVAAKGGVAMLTRAMAVDLARHGIL 190 Query: 174 VNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233 VN + P V + +S+P A+ +L+ + LG+ E V A +FL D S TGS Sbjct: 191 VNMIAPGPVDVTGNNTGYSEPRLAEQVLDEVALGRPGLPEEVATAAVFLAEDGSSFITGS 250 Query: 234 TLPVEGGFWA 243 T+ ++GG A Sbjct: 251 TITIDGGLSA 260 >3K2E-A nrPDB Length = 296 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 109/253 (43%), Gaps = 16/253 (6%) Query: 3 LFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQ---ADLDSLVRECPGIEPV 57 + + G++ ++ G K + G +A+ A GA V ++ +D L V Sbjct: 26 MLMEGKKGVIIGVANDKSLAWGIAKAVCAQGAEVALTYLSETFKKRVDPLAESLGVKLTV 85 Query: 58 CVDLGDWEATERAL----GSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLR 109 D+ D E+ + G +D +V+ A + L +++ + F S ++ Sbjct: 86 PCDVSDAESVDNMFKVLAEEWGSLDFVVHAVAFSDKNELKGRYVDTSLGNFLTSMHISCY 145 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + ++ + G+I+ +S +++ V +++V K AL+ K +A++LG Sbjct: 146 SFTYIASKAEPLM---TNGGSILTLSYYGAEKVVPHYNVMGVCKAALEASVKYLAVDLGK 202 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 +IRVNA++ V T + PL + ++ V A L+LLSD Sbjct: 203 QQIRVNAISAGPVRTLASSGISDFHYILTWNKYNSPLRRNTTLDDVGGAALYLLSDLGRG 262 Query: 230 TTGSTLPVEGGFW 242 TTG T+ V+ G+ Sbjct: 263 TTGETVHVDCGYH 275 >1HXH-A nrPDB Length = 253 Score = 190 bits (484), Expect = 4e-49, Method: Composition-based stats. Identities = 65/245 (26%), Positives = 107/245 (43%), Gaps = 12/245 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCV 59 L G+ LVTG G+G V+ L GA+V +A L E + Sbjct: 3 RLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSMFVRHDVS 62 Query: 60 DLGDWEATERALG-SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 DW A+ +G +++LVNNA + L E F R ++N +V Q Sbjct: 63 SEADWTLVMAAVQRRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQG 122 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK--IRVNA 176 + + G+I+N++S S + ++ Y ++K A+ LT+ AL IRVN+ Sbjct: 123 IAAM--KETGGSIINMASVSSWLPIEQYAGYSASKAAVSALTRAAALSCRKQGYAIRVNS 180 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAE---VEHVVNAILFLLSDRSGMTTGS 233 ++P + T M QA+ + +L+ L + E + +LFL SD S + +GS Sbjct: 181 IHPDGIYTPMMQASLPKGVSKEMVLHDPKLNRAGRAYMPERIAQLVLFLASDESSVMSGS 240 Query: 234 TLPVE 238 L + Sbjct: 241 ELHAD 245 >3GDF-A nrPDB Length = 267 Score = 189 bits (482), Expect = 6e-49, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 107/255 (41%), Gaps = 18/255 (7%) Query: 2 ELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQAD-LDSLVRECPG----- 53 +L L G+ V+VTGA KG+G + GA V ++A + V+E Sbjct: 15 QLSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVKELEKTYGIK 74 Query: 54 IEPVCVDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109 + + +E+ E+ + G +D + NA L+ + EA++ +V+L Sbjct: 75 AKAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDGSVEAWNHVVQVDLN 134 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVT--NHSVYCSTKGALDMLTKVMALEL 167 ++ V RG G++V +S A + Y K + + +A E Sbjct: 135 GTFHCAKAVGHHFKERGT-GSLVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEW 193 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 RVN+++P + T + + + + IP+G+ + + A ++ SD S Sbjct: 194 RDFA-RVNSISPGYIDTGLSDFVPKETQQL--WHSMIPMGRDGLAKELKGAYVYFASDAS 250 Query: 228 GMTTGSTLPVEGGFW 242 TTG+ L ++GG+ Sbjct: 251 TYTTGADLLIDGGYT 265 >5CFZ-A nrPDB Length = 305 Score = 189 bits (482), Expect = 7e-49, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 17/252 (6%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 FL+G+R+LVTG I G QA+H GA + + ++ + + Sbjct: 46 FLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQ 105 Query: 59 VDLGDWEATERALGSVGPV----DLLVNNAAVALLQPFL-----EVTKEAFDRSFEVNLR 109 D+ + + + +G V D V++ A VT+E F + +++ Sbjct: 106 CDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSY 165 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + +++ R ++ G A++ +S ++RA+ N++V K +L+ + MA +GP Sbjct: 166 SFVAMAKAC-RSMLNPGS--ALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGP 222 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 +RVNA++ + T P+ + +E V N+ FL SD S Sbjct: 223 EGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAG 282 Query: 230 TTGSTLPVEGGF 241 +G + V+GGF Sbjct: 283 ISGEVVHVDGGF 294 >5JS6-A nrPDB Length = 274 Score = 189 bits (482), Expect = 7e-49, Method: Composition-based stats. Identities = 64/227 (28%), Positives = 107/227 (47%), Gaps = 14/227 (6%) Query: 24 VQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGS----VGPVDL 79 V+A +GARVV + ++ +L +E PG + D+ + + + G +D Sbjct: 28 VRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDC 87 Query: 80 LVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQC 138 +VNNA Q E + + F + E+NL ++++ L R G ++N+SS Sbjct: 88 VVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYL--RKSQGNVINISSLV 145 Query: 139 SQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPH 195 Y +TKGA+ +TK +AL+ P+ +RVN ++P + T + + A DP Sbjct: 146 GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPR 205 Query: 196 KA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + ML + PLG+ + V A +FL S + TG L V GG Sbjct: 206 ATIREGMLAQ-PLGRMGQPAEVGAAAVFLAS-EANFCTGIELLVTGG 250 >4RGB-A nrPDB Length = 294 Score = 189 bits (482), Expect = 7e-49, Method: Composition-based stats. Identities = 76/270 (28%), Positives = 105/270 (38%), Gaps = 31/270 (11%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS------------RTQADLDSLVR-- 49 L GR V +TGA +G GR GA +V V T +L+ R Sbjct: 22 SLDGRVVFITGAARGQGRSHAVMCAEQGANIVGVDICEDIDIVPYKLGTYEELEETARLV 81 Query: 50 ECPGIEPVC--VDLGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRS 103 E G E + D+ D E + + G +D ++ NA V L P EA Sbjct: 82 EKTGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIANAGVVLTNPDERDASEALRLG 141 Query: 104 FEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQR----AVTNHSVYCSTKGALDML 159 ++ L V Q+ + RG G ++ SS + Y ++K A+ L Sbjct: 142 LDIMLIGVWNTFQVAIPHMKERGQGGNLIATSSMIALLDLTDGRGGTDAYLTSKLAITGL 201 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSM-------GQATWSDPHKAKTMLNRIPLGKFAEV 212 + AL L +IRVN V PT T M + +PH M +P E Sbjct: 202 VRSYALMLAADRIRVNGVAPTNCSTPMITENPALFKVIEENPHLVNAMSTALPDFPMIEP 261 Query: 213 EHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 V NAILFL+SD TGS L V+ G Sbjct: 262 RDVSNAILFLISDAGRSFTGSVLKVDAGMD 291 >4ALL-A nrPDB Length = 277 Score = 188 bits (479), Expect = 1e-48, Method: Composition-based stats. Identities = 64/257 (24%), Positives = 114/257 (44%), Gaps = 18/257 (7%) Query: 3 LFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSR---TQADLDSLVREC--PGIE 55 L L + ++ G + I G + L GA++V R ++ +L+ L+ + P Sbjct: 23 LNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAH 82 Query: 56 PVCVDLGDWEAT----ERALGSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVN 107 +D+ E E+ VG +D + ++ A A L F E ++E F + +++ Sbjct: 83 LYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDIS 142 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 ++ V+ + + G+IV + + AV N++V K +L+ K +AL+L Sbjct: 143 SYSLTIVAHEAKKLMPE---GGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDL 199 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 GP IRVNA++ + T + K + R PL + + V +LLSD S Sbjct: 200 GPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLS 259 Query: 228 GMTTGSTLPVEGGFWAC 244 TG + V+ GF A Sbjct: 260 SGVTGENIHVDSGFHAI 276 >4TRR-A nrPDB Length = 269 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 103/257 (40%), Gaps = 18/257 (7%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC----PGIEPVCV 59 L G+ +VTGA GIG+ L GA V Q +++ E V + Sbjct: 11 NLNGKTAVVTGAASGIGKEIALELAKAGAAVAIADLNQDGANAVADEINKAGGKAIGVAM 70 Query: 60 DLGDWEAT----ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 D+ + EA ++ + G VD+LV+NA + ++ P + + + +++ + Sbjct: 71 DVTNEEAVNTGIDKVAEAFGSVDILVSNAGIQIVNPIENYSFADWKKMQAIHVDGAFLTT 130 Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + + + G ++ + S S A S Y + K L L +V+A E H +R + Sbjct: 131 KAALKHMYKDDRGGVVIYMGSVHSHEASPLKSAYVTAKHGLLGLARVLAKEGAKHNVRSH 190 Query: 176 AVNPTVVMTSMGQA----------TWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225 V P V T + + K ML G F V+ V +LFL + Sbjct: 191 VVCPGFVRTPLVDKQIPEQAKELGISEEEVIKKVMLGNTVDGVFTTVQDVAQTVLFLSAF 250 Query: 226 RSGMTTGSTLPVEGGFW 242 S TG + V G++ Sbjct: 251 PSAALTGQSFIVSHGWF 267 >4JQC-A nrPDB Length = 282 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 17/252 (6%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 FL+G+R+LVTG I G QA+H GA + + ++ + + Sbjct: 23 FLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQ 82 Query: 59 VDLGDWEATERALGSVGPV----DLLVNNAAVALLQPFL-----EVTKEAFDRSFEVNLR 109 D+ + + + +G V D V++ A VT+E F + +++ Sbjct: 83 CDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSY 142 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + +++ R ++ G A++ +S ++RA+ N++V K +L+ + MA +GP Sbjct: 143 SFVAMAKAC-RSMLNPGS--ALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGP 199 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 +RVNA++ + T P+ + +E V N+ FL SD S Sbjct: 200 EGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAG 259 Query: 230 TTGSTLPVEGGF 241 +G + V+GGF Sbjct: 260 ISGEVVHVDGGF 271 >5I9N-A nrPDB Length = 276 Score = 186 bits (474), Expect = 6e-48, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 108/255 (42%), Gaps = 17/255 (6%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAV---SRTQADLDSLVRECPGIEPVC 58 FL G+R+L+TG + + I G +A GA + R + + E Sbjct: 3 FLDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGDRFKDRITEFAAEFGSELVFP 62 Query: 59 VDLGDWEATERALGS----VGPVDLLVNNAAVAL----LQPFLE-VTKEAFDRSFEVNLR 109 D+ D + S +D LV++ A FL+ +T+E F + +++ Sbjct: 63 CDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISAY 122 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + +++ L +++ +S ++RA+ N++ K AL+ + +A+ LG Sbjct: 123 SFPALAKAALPMLSDD---ASLLTLSYLGAERAIPNYNTMGLAKAALEASVRYLAVSLGA 179 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGM 229 +RVNA++ + T S + + PL + +E V NA FLLSD + Sbjct: 180 KGVRVNAISAGPIKTLAASGIKSFGKILDFVESNSPLKRNVTIEQVGNAGAFLLSDLASG 239 Query: 230 TTGSTLPVEGGFWAC 244 T + V+ GF A Sbjct: 240 VTAEVMHVDSGFNAV 254 >4NK4-A nrPDB Length = 301 Score = 183 bits (464), Expect = 9e-47, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 110/254 (43%), Gaps = 16/254 (6%) Query: 1 MELFLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQ---ADLDSLVRECPGIE 55 M L G+R L+ G I G + LH+ GA++ + + L L Sbjct: 35 MINILKGKRGLIMGVANDHSIAWGIAKVLHSAGAQLAFSYQGESIGKRLKPLALTVDSDF 94 Query: 56 PVCVDLGDWEA----TERALGSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVN 107 + ++ D + ER +D +V++ A + L P+ +++ F ++ V+ Sbjct: 95 MIPCNVEDPSSMDLLFERIKERWETLDFVVHSIAFSDKNELRGPYYNTSRDNFIQTMLVS 154 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 + ++ + A+ + GA++ ++ S R V N++ K AL+ TK +A + Sbjct: 155 CFSFTEIVRRAAQLMP---HGGAMITLTYGGSMRVVPNYNAMAPAKSALESSTKYLACDY 211 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 G IR+NA++ V T G + + A PL + +E + N+ L+LLS S Sbjct: 212 GGMNIRINAISAGPVRTLAGASISNGRDIAAWSKENSPLKRTVSLEDIGNSALYLLSYLS 271 Query: 228 GMTTGSTLPVEGGF 241 TG V+ G+ Sbjct: 272 NGVTGEIHYVDCGY 285 >4NR0-A nrPDB Length = 273 Score = 183 bits (464), Expect = 9e-47, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 107/254 (42%), Gaps = 18/254 (7%) Query: 4 FLAGRRVLVTGAGK--GIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVC 58 FL G+R L+ G I G A+H GA + + ++ +C Sbjct: 3 FLTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGRVEEFASGWGSRPELC 62 Query: 59 --VDLGDWEATERALGSVG----PVDLLVNNAAVAL----LQPFLE-VTKEAFDRSFEVN 107 D+ D E ++G +D++V++ A F T+E F + +++ Sbjct: 63 FPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDIS 122 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 + I +++ + +G G+++ +S ++R + N++V K +L+ + +A L Sbjct: 123 AYSFIALAKAGRE--MMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLEAGVRYLAGSL 180 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 G RVNAV+ + T S + PL + +E V NA FL SD + Sbjct: 181 GAEGTRVNAVSAGPIRTLAASGIKSFRKMLAANERQTPLRRNVTIEEVGNAGAFLCSDLA 240 Query: 228 GMTTGSTLPVEGGF 241 +G L V+GGF Sbjct: 241 SGISGEILYVDGGF 254 >3V8B-A nrPDB Length = 283 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 78/250 (31%), Positives = 118/250 (47%), Gaps = 19/250 (7%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI----EPVCVDLGDW 64 L+TGAG GIGR T AL A G V A+ RT+ +++ + E G + D+ D Sbjct: 30 VALITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVGAGGQAIALEADVSDE 89 Query: 65 ----EATERALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 A + G +D++V NA + + P ++ +D + VNLR + Sbjct: 90 LQMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFEWDETIAVNLRGTFLTLHLTV 149 Query: 120 RGLIARGVPGAIVNVSSQCSQRAV--TNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 L RG GAIV VSS R + Y +TK A + + +ALELG H IRVNAV Sbjct: 150 PYLKQRG-GGAIVVVSSINGTRTFTTPGATAYTATKAAQVAIVQQLALELGKHHIRVNAV 208 Query: 178 NPTVVMTSMGQATWSDPHKA-----KTMLNRIPL--GKFAEVEHVVNAILFLLSDRSGMT 230 P + T++ T + + ++P+ G+ E V I FL+S+R+ Sbjct: 209 CPGAIETNISDNTKLRHEEETAIPVEWPKGQVPITDGQPGRSEDVAELIRFLVSERARHV 268 Query: 231 TGSTLPVEGG 240 TGS + ++GG Sbjct: 269 TGSPVWIDGG 278 >3ZV3-A nrPDB Length = 281 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 110/258 (42%), Gaps = 22/258 (8%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-VRECPGIEPVCVDL 61 + L G L+TG G+GR V A GARV + ++ L L V V D+ Sbjct: 1 MKLTGEVALITGGASGLGRALVDRFVAEGARVAVLDKSAERLRELEVAHGGNAVGVVGDV 60 Query: 62 GDWE----ATERALGSVGPVDLLVNNAAV-----ALLQPFLEVTKEAFDRSFEVNLRAVI 112 + A ER L + G +D L+ NA + AL + AFD F VN++ I Sbjct: 61 RSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNVKGYI 120 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + L++ G++V S +Y +TK A+ L + MA EL PH + Sbjct: 121 HAVKACLPALVS--SRGSVVFTISNAGFYPNGGGPLYTATKHAVVGLVRQMAFELAPH-V 177 Query: 173 RVNAVNPTVVMTS--------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 RVN V P + T + + + S A + + +P+G+ +E A +F + Sbjct: 178 RVNGVAPGGMNTDLRGPSSLGLSEQSISSVPLADMLKSVLPIGRMPALEEYTGAYVFFAT 237 Query: 225 -DRSGMTTGSTLPVEGGF 241 S TG+ L +GG Sbjct: 238 RGDSLPATGALLNYDGGM 255 >2X9N-A nrPDB Length = 288 Score = 180 bits (457), Expect = 5e-46, Method: Composition-based stats. Identities = 73/262 (27%), Positives = 103/262 (39%), Gaps = 34/262 (12%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL-----DSLVRECPGIEPVC-VDLGD 63 +VTGA K IGR LH TG RVV A+ D L +E VC DL + Sbjct: 26 AVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTN 85 Query: 64 --------WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEA----------FDRSFE 105 E + G D+LVNNA+ P ++ E Sbjct: 86 SNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHEDNSNGKTVETQVAELIG 145 Query: 106 VNLRAVIQVSQIVARGLIARG-----VPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT 160 N A ++ A+ +IVN+ + S+Y K AL LT Sbjct: 146 TNAIAPFLLTMSFAQRQKGTNPNCTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLT 205 Query: 161 KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKF-AEVEHVVNAI 219 + ALEL P+ IRVN V P V + ++PLG+ A E + +A+ Sbjct: 206 QSAALELAPYGIRVNGVAPGV----SLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAV 261 Query: 220 LFLLSDRSGMTTGSTLPVEGGF 241 +FL+S + TGS + V+GG Sbjct: 262 IFLVSGSAQYITGSIIKVDGGL 283 >5JY1-A nrPDB Length = 274 Score = 179 bits (455), Expect = 9e-46, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 106/249 (42%), Gaps = 11/249 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP----VCV 59 L R LVTGAG GIGRG ++ GA V+ ++ + +E + V Sbjct: 11 LLEQRVALVTGAGGGIGRGVARSFGNEGAAVIIAEINESTGRQVEQEIREMGGRSLFVKT 70 Query: 60 DLGD----WEATERALGSVGPVDLLVNNAAVALLQ-PFLEVTKEAFDRSFEVNLRAVIQV 114 D+ A A+ G +D+LVNNA V E T E +++ +L A Sbjct: 71 DVTSKASIEAAVRSAVEQFGSLDILVNNAFVPTPNVLLEEKTDEMLEQTLTTSLWATWWA 130 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 + + R G IVN S ++ H Y + K + LT+ A E G I V Sbjct: 131 MRAAFVPMRER-RWGRIVNFYSIDTETGAWLHGDYNTAKAGIVGLTRSAASEWGRFNITV 189 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVE-HVVNAILFLLSDRSGMTTGS 233 NA+ PT + + + +P A+ PLG+ + E + A +F S+ S TG Sbjct: 190 NAIAPTAMGATFFELAAKNPEFAERSAAARPLGRSGDPEQDIGPAAVFFASEMSRFVTGE 249 Query: 234 TLPVEGGFW 242 TL V+GG Sbjct: 250 TLHVDGGLH 258 >4J3F-A nrPDB Length = 280 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 114/252 (45%), Gaps = 15/252 (5%) Query: 4 FLAGRRVLVTG--AGKGIGRGTVQALHATGARVVAVSRTQ--ADLDSLVRECPGIEPVCV 59 FLAG+++L+TG + K I G +A+H GA + Q ++ L E + Sbjct: 23 FLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPC 82 Query: 60 DLGDWEATERALGSVG----PVDLLVNNAAVALL----QPFLE-VTKEAFDRSFEVNLRA 110 D+ + + +G +D +V++ A A F++ VT+E F + +++ + Sbjct: 83 DVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYS 142 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 +++ R ++ + ++V ++ +++A+ +++ K +L+ + AL LG Sbjct: 143 FAALAKE-GRSMM-KNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGED 200 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 I+VNAV+ + T + PL K ++ V N + FL SD + Sbjct: 201 GIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGI 260 Query: 231 TGSTLPVEGGFW 242 TG + V+ G+ Sbjct: 261 TGEVVHVDAGYH 272 >5O3Z-A nrPDB Length = 263 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 113/253 (44%), Gaps = 20/253 (7%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---------ECPGIEPVC 58 + +V G G+ +G + L G V +++ + L G + Sbjct: 7 QVAVVIGGGQTLGAFLCEGLAQAGYHVAVADLNESNANRLADTINSRYGAGRAYGFKVDA 66 Query: 59 VDLGDWEATERAL-GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 D EA RA+ + G DLLV +A VA P + FD S +VNL S+ Sbjct: 67 TDEASVEALARAVDETFGRADLLVYSAGVAKAAPITQFRLTDFDLSLQVNLVGYFLCSRE 126 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177 ++ +I G+ G I+ ++S+ + ++S Y + K LT+ +AL+L + I V+++ Sbjct: 127 FSKLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVHSL 186 Query: 178 NPTV-VMTSMGQATWSDPHKAKTM---------LNRIPLGKFAEVEHVVNAILFLLSDRS 227 + + M Q+ + + ++++PL + + + V+N +LF SD++ Sbjct: 187 MLGNLLKSPMFQSLLPQYAEKLGITPEEVEPYYVDKVPLKRGCDYQDVLNVLLFYASDKA 246 Query: 228 GMTTGSTLPVEGG 240 TG ++ V GG Sbjct: 247 AYCTGQSINVTGG 259 >1BDB-A nrPDB Length = 277 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 66/258 (25%), Positives = 108/258 (41%), Gaps = 22/258 (8%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE-CPGIEPVCVDL 61 + L G VL+TG G+GR V A GA+V + ++ L L + + + D+ Sbjct: 1 MKLKGEAVLITGGASGLGRALVDRFVAEGAKVAVLDKSAERLAELETDHGDNVLGIVGDV 60 Query: 62 GDWE----ATERALGSVGPVDLLVNNAAV-----ALLQPFLEVTKEAFDRSFEVNLRAVI 112 E A R + G +D L+ NA + AL+ E AFD F +N++ I Sbjct: 61 RSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYI 120 Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + L+A G ++ S +Y + K A+ L + +A EL P+ + Sbjct: 121 HAVKACLPALVA--SRGNVIFTISNAGFYPNGGGPLYTAAKHAIVGLVRELAFELAPY-V 177 Query: 173 RVNAVNPTVVMTS--------MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 RVN V + + MG S A + + +P+G+ EVE A +F + Sbjct: 178 RVNGVGSGGINSDLRGPSSLGMGSKAISTVPLADMLKSVLPIGRMPEVEEYTGAYVFFAT 237 Query: 225 -DRSGMTTGSTLPVEGGF 241 + TG+ L +GG Sbjct: 238 RGDAAPATGALLNYDGGL 255 >1W73-A nrPDB Length = 302 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 109/248 (43%), Gaps = 12/248 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVC 58 G+ +TG G G+G+G L + GA+ V SR L + + + + Sbjct: 23 SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 82 Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D+ D + + + + G ++++NNAA + P ++ A+ ++ L V Sbjct: 83 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 142 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 + + + LI A +++++ ++ S K ++ ++K +A E G + +R Sbjct: 143 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 202 Query: 175 NAVNPTVVMTSMGQATWSDP--HKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232 N + P + T G + DP K M+ RIP G+ VE + N FL SD + G Sbjct: 203 NVIQPGPIKTK-GAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWING 261 Query: 233 STLPVEGG 240 + + +GG Sbjct: 262 AVIKFDGG 269 >2GDZ-A nrPDB Length = 267 Score = 174 bits (443), Expect = 2e-44, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 114/257 (44%), Gaps = 30/257 (11%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECPGIEP--- 56 M + G+ LVTGA +GIGR +AL GA+V V +A + EP Sbjct: 1 MAHMVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKT 60 Query: 57 --VCVDLGDWEA----TERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRA 110 + D+ D + + + G +D+LVNNA V ++ ++++ ++NL + Sbjct: 61 LFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVS 112 Query: 111 VIQVSQIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKV--MALE 166 VI + + + + G G I+N+SS V VYC++K + T+ +A Sbjct: 113 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 172 Query: 167 LGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFA------EVEHVVNAIL 220 L +R+NA+ P V T++ ++ + + + + + + + + N ++ Sbjct: 173 LMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLI 232 Query: 221 FLLSDRSGMTTGSTLPV 237 L+ D + G+ + + Sbjct: 233 TLIEDDA--LNGAIMKI 247 >2QHX-A nrPDB Length = 328 Score = 172 bits (436), Expect = 1e-43, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 115/282 (40%), Gaps = 55/282 (19%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSL-----VRECPGIEPVCVDLG 62 LVTGA K +GR + LHA G V + R+ A+ ++L R V DL Sbjct: 48 VALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLS 107 Query: 63 D---------------------WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFD 101 + E G D+LVNNA+ P L ++ + Sbjct: 108 NVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHE 167 Query: 102 --------------RSFEVNLRAVIQVSQIVAR-----GLIARGVPGAIVNVSSQCSQRA 142 F N A + + A RG +I+N+ + + Sbjct: 168 PCVGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQP 227 Query: 143 VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT--VVMTSMGQATWSDPHKAKTM 200 + +++Y KGAL+ LT+ ALEL P +IRVN V P V++ M A W + Sbjct: 228 LLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVW------EGH 281 Query: 201 LNRIPL-GKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 +++PL + + V + ++FL S ++ TG+ + V+GG+ Sbjct: 282 RSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGY 323 >2BFA-A nrPDB Length = 288 Score = 171 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 115/282 (40%), Gaps = 55/282 (19%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSL-----VRECPGIEPVCVDLG 62 LVTGA K +GR + LHA G V + R+ A+ ++L R V DL Sbjct: 8 VALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLS 67 Query: 63 D---------------------WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFD 101 + E G D+LVNNA+ P L ++ + Sbjct: 68 NVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHE 127 Query: 102 --------------RSFEVNLRAVIQVSQIVAR-----GLIARGVPGAIVNVSSQCSQRA 142 F N A + + A RG +I+N+ + + Sbjct: 128 PCVGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQP 187 Query: 143 VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT--VVMTSMGQATWSDPHKAKTM 200 + +++Y KGAL+ LT+ ALEL P +IRVN V P V++ M A W + Sbjct: 188 LLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVW------EGH 241 Query: 201 LNRIPL-GKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 +++PL + + V + ++FL S ++ TG+ + V+GG+ Sbjct: 242 RSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGY 283 >1P33-A nrPDB Length = 289 Score = 171 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 72/282 (25%), Positives = 115/282 (40%), Gaps = 55/282 (19%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARV-VAVSRTQADLDSLVRECPGIEP-----VCVDLG 62 LVTGA K +G +ALHA G V + R+ AD +L P V DL Sbjct: 9 VALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLS 68 Query: 63 DWEA---------------------TERALGSVGPVDLLVNNAAVALLQPFLE------- 94 + + G D+LVNNA+ P L Sbjct: 69 NVATASFSETDGSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKDAGEGG 128 Query: 95 ---VTKEAFD----RSFEVNLRAVIQVSQIVARGLI-----ARGVPGAIVNVSSQCSQRA 142 KE+ + F N A + + A+ + RG +IVN+ + + Sbjct: 129 SSVGDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQP 188 Query: 143 VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT--VVMTSMGQATWSDPHKAKTM 200 + +++Y K AL+ LT+ ALEL +IRVN V+P V+ M + D + Sbjct: 189 LLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRR---- 244 Query: 201 LNRIPL-GKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 ++PL + + E V + ++FL S ++ TG+ + V+GG+ Sbjct: 245 --KVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGY 284 >2PD3-A nrPDB Length = 275 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 16/252 (6%) Query: 4 FLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQ---ADLDSLVRECPGIEPVC 58 FL G++ L+ G K I G Q+ GA + + + + +E Sbjct: 3 FLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYE 62 Query: 59 VDLGDWEATERAL----GSVGPVDLLVNNAAVAL----LQPFLEVTKEAFDRSFEVNLRA 110 +D+ E + +G +D +V++ A A LE +K AF+ + E+++ + Sbjct: 63 LDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYS 122 Query: 111 VIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPH 170 +I+++ + L +++ +S S + + +++V K AL+ + +A++LG H Sbjct: 123 LIELTNTLKPLL---NNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKH 179 Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMT 230 IRVNA++ + T K PL K +E V NA ++LLS S Sbjct: 180 HIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSSGV 239 Query: 231 TGSTLPVEGGFW 242 +G V+ G+ Sbjct: 240 SGEVHFVDAGYH 251 >2BGM-A nrPDB Length = 278 Score = 165 bits (419), Expect = 1e-41, Method: Composition-based stats. Identities = 59/232 (25%), Positives = 97/232 (41%), Gaps = 14/232 (6%) Query: 24 VQALHATGARVVAVSRTQADLDSLVRECPG---IEPVCVDLGDWEAT----ERALGSVGP 76 + GA+VV + I V D+ E + + G Sbjct: 33 AKLFVRYGAKVVIADIADDHGQKVCNNIGSPDVISFVHCDVTKDEDVRNLVDTTIAKHGK 92 Query: 77 VDLLVNNAAVALLQP--FLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNV 134 +D++ N V P LE E F R ++N+ V++ AR +I G+IV Sbjct: 93 LDIMFGNVGVLSTTPYSILEAGNEDFKRVMDINVYGAFLVAKHAARVMIPA-KKGSIVFT 151 Query: 135 SSQCSQRAVTNHS-VYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWS- 192 +S S A S VY +TK A+ LT + ELG + IRVN V+P +V + + + Sbjct: 152 ASISSFTAGEGVSHVYTATKHAVLGLTTSLCTELGEYGIRVNCVSPYIVASPLLTDVFGV 211 Query: 193 DPHKAKTMLNRIP--LGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFW 242 D + + + ++ G E V +A+ +L D S +G L ++GG+ Sbjct: 212 DSSRVEELAHQAANLKGTLLRAEDVADAVAYLAGDESKYVSGLNLVIDGGYT 263 >3PXX-A nrPDB Length = 287 Score = 164 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 97/279 (34%), Gaps = 49/279 (17%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVS----------------RTQADLDSLVR 49 + VLVTG +G GR L GA ++ + + + Sbjct: 9 QDKVVLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEK 68 Query: 50 ECPGIEPVCVDLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFE 105 VD+ D A R A+ G +D++V NA + L + +AF +F+ Sbjct: 69 TGRKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGA--HLPVQAFADAFD 126 Query: 106 VNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSV-----------YCSTKG 154 V+ VI L + +I+ S A Y K Sbjct: 127 VDFVGVINTVHAALPYLTS---GASIITTGSVAGLIAAAQPPGAGGPQGPGGAGYSYAKQ 183 Query: 155 ALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQAT---------WSDPHKAKTMLNRIP 205 +D T +A +L P IR N ++PT V T M + P +A +L Sbjct: 184 LVDSYTLQLAAQLAPQSIRANVIHPTNVNTDMLNSAPMYRQFRPDLEAPSRADALLAFPA 243 Query: 206 LG----KFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + + E + NA+ FL SD S TG V+ G Sbjct: 244 MQAMPTPYVEASDISNAVCFLASDESRYVTGLQFKVDAG 282 >3OML-A nrPDB Length = 613 Score = 164 bits (416), Expect = 3e-41, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 94/247 (38%), Gaps = 31/247 (12%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVS---------RTQADLDSLVREC- 51 +L GR +VTGAG G+GR GA+VV +Q D +V E Sbjct: 14 KLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIR 73 Query: 52 -PGIEPVC---VDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVN 107 G E V + + E A+ + G VD+LVNNA + + ++ +++ ++ +V+ Sbjct: 74 KAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVH 133 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 L+ + +Q + + G I+ SS Y + K L L +A+E Sbjct: 134 LKGSFKCTQAAFPYMKKQNY-GRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEG 192 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFL----L 223 + + N + PT + M + D + + + + + +L Sbjct: 193 ARNNVLCNVIVPTA-ASRMTEGILPDILFNE-----------LKPKLIAPVVAYLCHESC 240 Query: 224 SDRSGMT 230 D Sbjct: 241 EDNGSYI 247 >2O23-A nrPDB Length = 265 Score = 161 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 21/253 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC-VDLG 62 + G ++TG G+G T + L GA V + + ++ ++ D+ Sbjct: 9 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVT 68 Query: 63 DWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVI 112 + + AL G VD+ VN A +A+ + K E F R +VNL Sbjct: 69 SEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTF 128 Query: 113 QVSQIVARGLIAR-----GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 V ++VA + G G I+N +S + + Y ++KG + +T +A +L Sbjct: 129 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 188 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLG-KFAEVEHVVNAILFLLSDR 226 P IRV + P + T + + + +++P + + + + Sbjct: 189 APIGIRVMTIAPGLFGTPLLTSLP--EKVCNFLASQVPFPSRLGDPAEYAHLVQ--AIIE 244 Query: 227 SGMTTGSTLPVEG 239 + G + ++G Sbjct: 245 NPFLNGEVIRLDG 257 >4DA9-A nrPDB Length = 280 Score = 161 bits (408), Expect = 2e-40, Method: Composition-based stats. Identities = 63/246 (25%), Positives = 105/246 (42%), Gaps = 14/246 (5%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD-----LDSLVRECPGIEPVCVDLGD 63 +VTG +GIG G +AL A+G + A+ + L + + DL D Sbjct: 31 VAIVTGGRRGIGLGIARALAASGFDIAITGIGDAEGVAPVIAELSGLGARVIFLRADLAD 90 Query: 64 ----WEATERALGSVGPVDLLVNNAAVA--LLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + + G +D LVNNA +A + FL++ E FD VNLR + +Q Sbjct: 91 LSSHQATVDAVVAEFGRIDCLVNNAGIASIVRDDFLDLKPENFDTIVGVNLRGTVFFTQA 150 Query: 118 VARGLIARGVPGA--IVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 V + ++A + I+N++S + YC +K L ++ +AL L I V Sbjct: 151 VLKAMLASDARASRSIINITSVSAVMTSPERLDYCMSKAGLAAFSQGLALRLAETGIAVF 210 Query: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235 V P ++ + M A +P+ ++ E E + N + L + G TGS + Sbjct: 211 EVRPGIIRSDMTAAVSGKYDGLIES-GLVPMRRWGEPEDIGNIVAGLAGGQFGFATGSVI 269 Query: 236 PVEGGF 241 +GG Sbjct: 270 QADGGL 275 >1E3W-A nrPDB Length = 261 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 99/253 (39%), Gaps = 21/253 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPVCVDLG 62 + G ++TG G+G T + L GA V + ++ ++ ++ G ++ Sbjct: 7 SVKGLVAVITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVT 66 Query: 63 DWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVI 112 + + AL G +D+ VN A +A+ K E F R VNL Sbjct: 67 SEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTF 126 Query: 113 QVSQIVARGLIAR-----GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 V ++VA + G G I+N +S + + Y ++KG + +T +A +L Sbjct: 127 NVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLG-KFAEVEHVVNAILFLLSDR 226 P IRV + P + T + + +++P + + + + ++ Sbjct: 187 APIGIRVVTIAPGLFATPLLTTLPDTVR--NFLASQVPFPSRLGDPAEYAHLVQMVI--E 242 Query: 227 SGMTTGSTLPVEG 239 + G + ++G Sbjct: 243 NPFLNGEVIRLDG 255 >2NWQ-A nrPDB Length = 272 Score = 156 bits (396), Expect = 6e-39, Method: Composition-based stats. Identities = 46/221 (20%), Positives = 88/221 (39%), Gaps = 14/221 (6%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---IEPVCVDLGDWE 65 + +TGA G G + G +V R + L +L E + P+ +D+ D Sbjct: 23 TLFITGATSGFGEACARRFAEAGWSLVLTGRREERLQALAGELSAKTRVLPLTLDVRDRA 82 Query: 66 ATERAL----GSVGPVDLLVNNAAVAL-LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 A A+ + L+NNA +AL P + +D + N++ ++ ++++ Sbjct: 83 AMSAAVDNLPEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNIKGLLYSTRLLLP 142 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 LIA G +IVN+ S + VY TK ++ + + +L +RV + P Sbjct: 143 RLIAHGAGASIVNLGSVAGKWPYPGSHVYGGTKAFVEQFSLNLRCDLQGTGVRVTNLEPG 202 Query: 181 VVMTS--MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAI 219 + + + + KT P+ + E + I Sbjct: 203 LCESEFSLVRFGGDQARYDKTYAGAHPI----QPEDIAETI 239 >3RKU-A nrPDB Length = 287 Score = 156 bits (396), Expect = 6e-39, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 104/248 (41%), Gaps = 21/248 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHAT---GARVVAVSRTQADLDSLVRECP------GI 54 LA + VL+TGA GIG+ T +++ +R L+ L + + Sbjct: 30 RLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKV 89 Query: 55 EPVCVDLGDWEATERALG----SVGPVDLLVNNAAVALLQPFL-EVTKEAFDRSFEVNLR 109 +D+ E + + +D+LVNNA AL + ++ E F+ N+ Sbjct: 90 HVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVT 149 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 A+I ++Q V A+ G IVN+ S + A S+YC++K A+ T + EL Sbjct: 150 ALINITQAVLPIFQAKN-SGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELIN 208 Query: 170 HKIRVNAVNPTVVMTS--MGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRS 227 KIRV + P +V T + + ++ + PL + V + I++ S + Sbjct: 209 TKIRVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPL----MADDVADLIVYATSRKQ 264 Query: 228 GMTTGSTL 235 TL Sbjct: 265 NTVIADTL 272 >3E9N-A nrPDB Length = 245 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 101/239 (42%), Gaps = 16/239 (6%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + L + +VTGA G+G V+ L V A+ R L +L E G+EP+ D+ Sbjct: 1 MSLKKKIAVVTGATGGMGIEIVKDLSRD-HIVYALGRNPEHLAALA-EIEGVEPIESDIV 58 Query: 63 DW---EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 E L ++ VD LV+ AAVA + + ++N+ ++S+ + Sbjct: 59 KEVLEEGGVDKLKNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLL 118 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 L R G ++ ++S +++Y ++K AL L E + IRV+ V+P Sbjct: 119 PAL--RAASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRKEEANNGIRVSTVSP 176 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 T M Q + I + E + + NAI F++ +G TT V+ Sbjct: 177 GPTNTPMLQGLMDS--QGTNFRPEI----YIEPKEIANAIRFVI--DAGETT-QITNVD 226 >5IZ4-A nrPDB Length = 271 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 97/254 (38%), Gaps = 22/254 (8%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLVRECPGIEPVC--VDL 61 ++TG+ GIG T G V +R A + G + + D+ Sbjct: 16 VCVITGSASGIGAATALRFAQAGWSVAIGNFDDSTRDAASTVEALCRDAGAQTLIFDADV 75 Query: 62 GDWEATERALGSVG----PVDLLVNNAAVALLQP---FLEVTKEAFDRSFEVNLRAVIQV 114 G A+ V +D L+N A + P F ++ F+R + VNL + Q+ Sbjct: 76 GKDADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLIGLYQM 135 Query: 115 SQIVARGL---IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK 171 ++ L + ++VNVSS + Y ++KGA++ LT +A L PH Sbjct: 136 TRAAVPLLRESASATRSTSVVNVSSLAGLNGTGSSIAYAASKGAVNTLTLSLARNLAPH- 194 Query: 172 IRVNAVNPTVVMTSMGQATWSDPHK---AKTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228 IRVNA+ P +V + M PL + + + FL + + Sbjct: 195 IRVNALAPGMVDDGLLLRVLDAAAYDGVLSRMTESAPLKRVSRPAEIAELAWFL-TAHAP 253 Query: 229 MTTGSTLPVEGGFW 242 TG + E G Sbjct: 254 AITGQVIAAENGLL 267 >1A27-A nrPDB Length = 289 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 95/241 (39%), Gaps = 30/241 (12%) Query: 9 RVLVTGAGKGIGRGTVQALHA---TGARVVAV-------SRTQADLDSLVRECPGIEPVC 58 VL+TG GIG L + +V A R +L +E + Sbjct: 4 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 63 Query: 59 VDLGDWEATERALGSV--GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 +D+ D ++ A V G VD+LV NA + LL P + ++A +VN+ +++ Q Sbjct: 64 LDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQ 123 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + RG G ++ S + + VYC++K AL+ L + +A+ L P + ++ Sbjct: 124 AFLPDMKRRG-SGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSL 182 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAE---------------VEHVVNAILF 221 + V T+ + P + + +F + E V +F Sbjct: 183 IECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAE--VF 240 Query: 222 L 222 L Sbjct: 241 L 241 >3PPI-A nrPDB Length = 281 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 96/251 (38%), Gaps = 20/251 (7%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-IEPVCVDLGD 63 G +V+G G+G TV+ LHA G VV +L E E V ++ Sbjct: 28 FEGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRAEFVSTNVTS 87 Query: 64 WEATERALGSVGPVDLL----VNNAAVALLQPFLE-----VTKEAFDRSFEVNLRAVIQV 114 ++ A+ + + L V + + Q ++ F ++ ++ L V Sbjct: 88 EDSVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYLNGTYNV 147 Query: 115 SQIVARGLIA-----RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 +++VA + A G GA+V +S + Y + K + LT A +L Sbjct: 148 ARLVAASIAAAEPRENGERGALVLTASIAGYEGQIGQTAYAAAKAGVIGLTIAAARDLSS 207 Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPL-GKFAEVEHVVNAILFLLSDRSG 228 IRVN + P + T + ++ IP + + +A FLL++ G Sbjct: 208 AGIRVNTIAPGTMKTPIMESVG--EEALAKFAANIPFPKRLGTPDEFADAAAFLLTN--G 263 Query: 229 MTTGSTLPVEG 239 G + ++G Sbjct: 264 YINGEVMRLDG 274 >6CGE-A nrPDB Length = 328 Score = 148 bits (374), Expect = 2e-36, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 95/241 (39%), Gaps = 30/241 (12%) Query: 9 RVLVTGAGKGIGRGTVQALHATG---ARVVAV-------SRTQADLDSLVRECPGIEPVC 58 VL+TG GIG L + +V A R +L +E + Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64 Query: 59 VDLGDWEATERALGSV--GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 +D+ D ++ A V G VD+LV NA + LL P + ++A +VN+ +++ Q Sbjct: 65 LDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQ 124 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176 + RG G ++ S + + VYC++K AL+ L + +A+ L P + ++ Sbjct: 125 AFLPDMKRRG-SGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSL 183 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAE---------------VEHVVNAILF 221 + V T+ + P + + +F + E V +F Sbjct: 184 IECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAE--VF 241 Query: 222 L 222 L Sbjct: 242 L 242 >4Q9N-A nrPDB Length = 298 Score = 146 bits (370), Expect = 6e-36, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 103/286 (36%), Gaps = 49/286 (17%) Query: 1 MELFLAGRRVLVTGAG--KGIGRGTVQALHATGARVVAVS----------------RTQA 42 +++ L G+ + G G G G G + L GA ++ + + Sbjct: 2 LKIDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNAS 61 Query: 43 DLDSLVRECPGIEPVCVDLG------------------------DWEATERALGSVGPVD 78 S + +D E E+ G +D Sbjct: 62 RELSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHID 121 Query: 79 LLVNNAAVAL--LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSS 136 +LV++ A + +P L+ +++ + + + + I + + + ++++ Sbjct: 122 ILVHSLANSPEIAKPLLDTSRKGYLAALSTSSYSFISLLSHFGPIM---NAGASTISLTY 178 Query: 137 QCSQRAVTNHSV-YCSTKGALDMLTKVMALELGPH-KIRVNAVNPTVVMTSMGQATWSDP 194 S RAV + + K AL+ TKV+A E G +RVN ++ + + G+A Sbjct: 179 LASMRAVPGYGGGMNAAKAALESDTKVLAWEAGRRWGVRVNTISAGPLASRAGKAIGFIE 238 Query: 195 HKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240 + PL E E V A FL+S + TG TL V+ G Sbjct: 239 RMVDYYQDWAPLPSPMEAEQVGAAAAFLVSPLASAITGETLYVDHG 284 >4DRY-A nrPDB Length = 281 Score = 146 bits (370), Expect = 7e-36, Method: Composition-based stats. Identities = 58/213 (27%), Positives = 85/213 (39%), Gaps = 14/213 (6%) Query: 23 TVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVCVDLGDWEATERALG----S 73 QAL A G VV R LD+ E G + V D+GD + Sbjct: 49 IAQALSAEGYSVVITGRRPDVLDAAAGEIGGRTGNIVRAVVCDVGDPDQVAALFAAVRAE 108 Query: 74 VGPVDLLVNNAAVA-LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARG-VPGAI 131 +DLLVNNA P EVT E ++ NL +Q R + A+ G I Sbjct: 109 FARLDLLVNNAGSNVPPVPLEEVTFEQWNGIVAANLTGAFLCTQHAFRMMKAQTPRGGRI 168 Query: 132 VNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATW 191 +N S +Q N + Y +TK A+ LTK AL+ H I ++ T M Sbjct: 169 INNGSISAQTPRPNSAPYTATKHAITGLTKSTALDGRMHDIACGQIDIGNAATDMTARMS 228 Query: 192 SDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLS 224 + +A + P +EH+ A++++ S Sbjct: 229 TGVLQANGEVAAEP---TIPIEHIAEAVVYMAS 258 >2DKN-A nrPDB Length = 255 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 100/262 (38%), Gaps = 43/262 (16%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 + +TG+ GIG + L G V+ + R QAD+++ + G E + D Sbjct: 3 VIAITGSASGIGAALKELLARAGHTVIGIDRGQADIEADLSTPGGRETAVAAVLDRCG-- 60 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVP 128 G +D LV A V VT VN V + +A L P Sbjct: 61 ------GVLDGLVCCAGVG-------VTAANSGLVVAVNYFGVSALLDGLAEALSRGQQP 107 Query: 129 GAIVNVSSQCSQRAVT--------------------------NHSVYCSTKGALDMLTKV 162 A++ V S + + H Y +K A+ L + Sbjct: 108 AAVI-VGSIAATQPGAAELPMVEAMLAGDEARAIELAEQQGQTHLAYAGSKYAVTCLARR 166 Query: 163 MALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEVEHVVNAILF 221 ++ +R+N V P V T + QA+ +DP ++ + PLG+ +E V AI F Sbjct: 167 NVVDWAGRGVRLNVVAPGAVETPLLQASKADPRYGESTRRFVAPLGRGSEPREVAEAIAF 226 Query: 222 LLSDRSGMTTGSTLPVEGGFWA 243 LL ++ GS L V+GG A Sbjct: 227 LLGPQASFIHGSVLFVDGGMDA 248 >1ENP-A nrPDB Length = 312 Score = 144 bits (364), Expect = 3e-35, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 109/285 (38%), Gaps = 49/285 (17%) Query: 5 LAGRRVLVTGAG--KGIGRGTVQALHATGARVVA------------------VSRTQADL 44 L G+R + G G G ++L A GA ++ +++ Sbjct: 16 LRGKRAFIAGIADDNGYGWAVAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDQSRVLP 75 Query: 45 DSLVRECPGIEPVCV----------DL------------GDWEATERALGSVGPVDLLVN 82 D + E + P+ D+ EA E G +D+LV+ Sbjct: 76 DGSLMEIKKVYPLDAVFDNPEDVPEDVKANKRYAGSSNWTVQEAAECVRQDFGSIDILVH 135 Query: 83 NAAVAL--LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQ 140 + A +P LE +++ + + + + + + + GA ++++ S+ Sbjct: 136 SLANGPEVSKPLLETSRKGYLAAISASSYSFVSLLSHFLPIM---NPGGASISLTYIASE 192 Query: 141 RAVTNHSV-YCSTKGALDMLTKVMALELG-PHKIRVNAVNPTVVMTSMGQATWSDPHKAK 198 R + + S K AL+ T+V+A E G IRVN ++ + + +A + Sbjct: 193 RIIPGYGGGMSSAKAALESDTRVLAFEAGRKQNIRVNTISAGPLGSRAAKAIGFIDTMIE 252 Query: 199 TMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243 N P+ K + V NA FL+S + TG+T+ V+ G + Sbjct: 253 YSYNNAPIQKTLTADEVGNAAAFLVSPLASAITGATIYVDNGLNS 297 >4HBG-A nrPDB Length = 286 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 58/274 (21%), Positives = 98/274 (35%), Gaps = 59/274 (21%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE---------PVCV 59 +VTGA +GIG+ Q L G + + T+ ++ + ++ + + Sbjct: 6 VAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQSGLSYQRQCAIAI 65 Query: 60 DLGDW---------EATERALGS----------VGP------------VDLLVNNAAVAL 88 D W + E P V+LL+N A + Sbjct: 66 DFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAGLTQ 125 Query: 89 LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR--------GVPGA--IVNVSSQ- 137 + T VN + + ++ I + ++ G IVN+SS Sbjct: 126 ESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSIL 185 Query: 138 -CSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM-TSMGQATWSDPH 195 + V SVY ++K AL T+V+A E+ P IR ++P +V T M Q P Sbjct: 186 HSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQNL---PV 242 Query: 196 KAKTMLNRIPLGKFAE--VEHVVNAILFLLSDRS 227 +AK ML R +G + + L S + Sbjct: 243 EAKEMLERT-IGASGTSAPAEIAEEVWSLYSRTA 275 >2O2S-A nrPDB Length = 315 Score = 140 bits (354), Expect = 4e-34, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 108/291 (37%), Gaps = 55/291 (18%) Query: 5 LAGRRVLVTGAGK--GIGRGTVQALHATGARVVA------------------VSRTQADL 44 L G+ V G G G + L + GARV + + Sbjct: 7 LRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLP 66 Query: 45 DSLVRECPGIEPVCV----------DLGD------------WEATERALGSVGPVDLLVN 82 D + E G+ P+ D+ D E + +G +D+LV+ Sbjct: 67 DGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVH 126 Query: 83 NAAVAL--LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQ 140 + A +P LE +++ + + + + + + Q + G+ V +S ++ Sbjct: 127 SLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIM---NEGGSAVTLSYLAAE 183 Query: 141 RAVTNHSV-YCSTKGALDMLTKVMALELG-PHKIRVNAVNPTVVMTSMGQATWSDPHKA- 197 R V + S K AL+ T+ +A E G + +RVNA++ + + A K+ Sbjct: 184 RVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSF 243 Query: 198 -----KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWA 243 N PL + + V A LFLLS + +G TL V+ G A Sbjct: 244 IDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHA 294 >3DWF-A nrPDB Length = 276 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 56/222 (25%), Positives = 89/222 (40%), Gaps = 19/222 (8%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PGIEPVC 58 L G++V+VTGA KGIGR L GA VV +R++ L +V C + Sbjct: 8 MLQGKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGAASAHYIA 67 Query: 59 VDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 + D E + +G +D+L+ N + F + +S EVN + + + Sbjct: 68 GSMEDMTFAEEFVAEAGNLMGGLDMLILNHVLYNRLTFFHGEIDNVRKSMEVNFHSFVVL 127 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S L+ G+I VSS + + Y ++K ALD + E V Sbjct: 128 SVAAMPMLMQSQ--GSIAVVSSVAGKITYPLIAPYSASKFALDGFFSTLRSEF-----LV 180 Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVV 216 N VN ++ + +G D A + I LG + E Sbjct: 181 NKVNVSITLCILG---LIDTETAIKATSGIYLGPASPKEECA 219 >5PGZ-A nrPDB Length = 276 Score = 137 bits (345), Expect = 5e-33, Method: Composition-based stats. Identities = 47/194 (24%), Positives = 79/194 (40%), Gaps = 15/194 (7%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PGIEPVC 58 L G++V+VTGA KGIGR L GA VV +R++ L +V C + Sbjct: 15 MLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIA 74 Query: 59 VDLGDWEATERAL----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 + D E+ + +G +D+L+ N + R EVN + + + Sbjct: 75 GTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVM 134 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174 S + + G+I +SS + + Y ++K ALD + EL K+ V Sbjct: 135 STAALP--MLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNV 192 Query: 175 N---AVNPTVVMTS 185 + V ++ T Sbjct: 193 SITLCVL-GLIDTE 205 >5ILO-A nrPDB Length = 271 Score = 136 bits (344), Expect = 6e-33, Method: Composition-based stats. Identities = 47/197 (23%), Positives = 77/197 (39%), Gaps = 21/197 (10%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR-----ECPGIEPVC 58 G+ +VTG GIG + L A GA VA+ Q +L+ V+ + + Sbjct: 12 SFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIK 71 Query: 59 VDLGDWEATERALGS----VGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 +D+ + + E G +D++VN A + + R+ VNL +I Sbjct: 72 MDVANKKGVEATYEEIAKTFGNIDIVVNVAGI--------FNDKDVQRTLLVNLGGIINS 123 Query: 115 SQIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALE--LGPH 170 + + G G +VN+SS + VY +TK + T+ +A E Sbjct: 124 TLSALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRS 183 Query: 171 KIRVNAVNPTVVMTSMG 187 I+ V P MT M Sbjct: 184 GIKFVTVCPGATMTDMF 200 >1FJH-A nrPDB Length = 257 Score = 134 bits (337), Expect = 4e-32, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 100/270 (37%), Gaps = 55/270 (20%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 ++++G GIG T + L A G ++V + A+ V DL E + Sbjct: 3 IIVISGCATGIGAATRKVLEAAGHQIVGIDIRDAE-------------VIADLSTAEGRK 49 Query: 69 RALGSV-----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +A+ V +D LV A + L VN ++ L Sbjct: 50 QAIADVLAKCSKGMDGLVLCAGLGPQTKVL-------GNVVSVNYFGATELMDAFLPALK 102 Query: 124 ARGVPGAIVNVSSQCSQ---------------------RAVTNHS-------VYCSTKGA 155 P A+V +SS S RA+ H+ Y +K A Sbjct: 103 KGHQPAAVV-ISSVASAHLAFDKNPLALALEAGEEAKARAIVEHAGEQGGNLAYAGSKNA 161 Query: 156 LDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRI-PLGKFAEVEH 214 L + + A G +R+N + P T + QA DP +++ + P+G+ AE Sbjct: 162 LTVAVRKRAAAWGEAGVRLNTIAPGATETPLLQAGLQDPRYGESIAKFVPPMGRRAEPSE 221 Query: 215 VVNAILFLLSDRSGMTTGSTLPVEGGFWAC 244 + + I FL+S + G+ + ++GG A Sbjct: 222 MASVIAFLMSPAASYVHGAQIVIDGGIDAV 251 >3UCF-A nrPDB Length = 223 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 103/242 (42%), Gaps = 27/242 (11%) Query: 3 LFLAGRRV-LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 + + + V +V G GIG + L + +V V+ Q L D+ Sbjct: 1 MMGSDKTVYVVLGGTSGIGAELAKQLESE-HTIVHVASRQTGL---------------DI 44 Query: 62 GDWEATERALGSVGPVDLLVNNAA-VALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 D ++ ++G D L+ A A ++V +F+ + ++ AR Sbjct: 45 SDEKSVYHYFETIGAFDHLIVTAGSYAPAGKVVDVEVTQAKYAFDTKFWGAVLAAKHGAR 104 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 L G+I S S++ V N V + A++ TKV+A EL P IRVNA++P Sbjct: 105 YLK---QGGSITLTSGMLSRKVVANTYVKAAINAAIEATTKVLAKELAP--IRVNAISPG 159 Query: 181 VVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVE 238 + T + +D A + + +P+GK E + A LF + ++ TG+ + V+ Sbjct: 160 LTKTEAYKGMNADDRDAMYQRTQSHLPVGKVGEASDIAMAYLFAI--QNSYMTGTVIDVD 217 Query: 239 GG 240 GG Sbjct: 218 GG 219 >3KZV-A nrPDB Length = 254 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 50/210 (23%), Positives = 91/210 (43%), Gaps = 12/210 (5%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGAR--VVAVSRTQADLDSLVRE-CPGIEPVCVDLGD 63 G+ +LVTG +GIG+ V L + V V+R++A L L + V D+ + Sbjct: 2 GKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDITE 61 Query: 64 ----WEATERALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + A+ G +D LV NA V +Q E+ A+ + +++N +++ + I Sbjct: 62 DSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVGIA 121 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 L G +V VSS ++ Y S+K AL+ +A E +++ AV Sbjct: 122 LPELKK--TNGNVVFVSSDACNMYFSSWGAYGSSKAALNHFAMTLANE--ERQVKAIAVA 177 Query: 179 PTVVMTSMGQATWSDPHKAKTMLNRIPLGK 208 P +V T M + + ++ + + Sbjct: 178 PGIVDTDMQVNIRENVGPSSMSAEQLKMFR 207 >2PTG-A nrPDB Length = 319 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 104/304 (34%), Gaps = 68/304 (22%) Query: 5 LAGRRVLVTGAG--KGIGRGTVQALHATGARV---------------------------- 34 L G+ V G G G + L A GARV Sbjct: 7 LRGKTAFVAGVADSNGYGWAICKLLRAAGARVLVGTWPPVYSIFKKGLESSRFEQDSFYA 66 Query: 35 ------VAVSRTQADLDSLVRECPGIEPVCVDLGDW-------------------EATER 69 VA + +D + + ++ V D E E Sbjct: 67 QEPSSKVAAEAAEKPVDLVFDKIYPLDAVFDTPQDVPPEVSSNKRYAGVGGFTISEVAEA 126 Query: 70 ALGSVGPVDLLVNNAAVAL--LQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 VG +D+LV++ A +P L+ +++ + + + + + + Q + Sbjct: 127 VRADVGQIDILVHSLANGPEVTKPLLQTSRKGYLAAVSSSSYSFVSLLQHFLPLMKE--- 183 Query: 128 PGAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELGP-HKIRVNAVNPTVVMTS 185 G+ + +S S++ + + S K AL+ + +A E G +RVN ++ + + Sbjct: 184 GGSALALSYIASEKVIPGYGGGMSSAKAALESDCRTLAFEAGRARAVRVNCISAGPLKSR 243 Query: 186 MGQATWSDPHKA------KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239 A K PL K E + V A LFLLS + TG+TL V+ Sbjct: 244 AASAIGKAGDKTFIDLAIDYSEANAPLQKELESDDVGRAALFLLSPLARAVTGATLYVDN 303 Query: 240 GFWA 243 G A Sbjct: 304 GLHA 307 >1SNY-A nrPDB Length = 267 Score = 118 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 46/204 (22%), Positives = 88/204 (43%), Gaps = 26/204 (12%) Query: 10 VLVTGAGKGIGRGTVQALHA-----TGARVVAVSRTQA-DLDSLVRECPGIEPVCVDLGD 63 +L+TG +G+G G V+AL +R QA +L+ L + I + +DL + Sbjct: 24 ILITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKELEDLAKNHSNIHILEIDLRN 83 Query: 64 WEATERALGSVGP------VDLLVNNAAVAL-LQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 ++A ++ + + +++L NNA +A V + + + N I +++ Sbjct: 84 FDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTLQTNTVVPIMLAK 143 Query: 117 IVARGLIARGV----------PGAIVNVSSQCS-QRAV--TNHSVYCSTKGALDMLTKVM 163 L AI+N+SS + Y ++K AL+ TK + Sbjct: 144 ACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRTSKSALNAATKSL 203 Query: 164 ALELGPHKIRVNAVNPTVVMTSMG 187 +++L P +I +++P V T MG Sbjct: 204 SVDLYPQRIMCVSLHPGWVKTDMG 227 >4Z3K-A nrPDB Length = 275 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 111/247 (44%), Gaps = 26/247 (10%) Query: 1 MELFLAGRRVLVTGAGKGIGR---GTVQALHATGARVVAVSRTQADLDSLVRECPG---- 53 ME L L+TGA +G GR + +L + G+ +V +R L L E Sbjct: 15 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 74 Query: 54 --IEPVCVDLGDWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTKE-AF 100 + V DLG ++ LG++ + LL+NNA + + F++++ Sbjct: 75 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 134 Query: 101 DRSFEVNLRAVIQVSQIVARGL-IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + + +NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML Sbjct: 135 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 194 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPHKAKTMLNRIPLGKFAEVEHVV 216 +V+ALE +RV P + T M Q T DP K + GK + + Sbjct: 195 FQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSA 252 Query: 217 NAILFLL 223 +L LL Sbjct: 253 QKLLSLL 259 >4HWK-A nrPDB Length = 288 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 111/247 (44%), Gaps = 26/247 (10%) Query: 1 MELFLAGRRVLVTGAGKGIGR---GTVQALHATGARVVAVSRTQADLDSLVRECPG---- 53 ME L L+TGA +G GR + +L + G+ +V +R L L E Sbjct: 28 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 87 Query: 54 --IEPVCVDLGDWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTKE-AF 100 + V DLG ++ LG++ + LL+NNA + + F++++ Sbjct: 88 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 147 Query: 101 DRSFEVNLRAVIQVSQIVARGL-IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML 159 + + +NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML Sbjct: 148 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 207 Query: 160 TKVMALELGPHKIRVNAVNPTVVMTSMGQ---ATWSDPHKAKTMLNRIPLGKFAEVEHVV 216 +V+ALE +RV P + T M Q T DP K + GK + + Sbjct: 208 FQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSA 265 Query: 217 NAILFLL 223 +L LL Sbjct: 266 QKLLSLL 272 >2HRB-A nrPDB Length = 274 Score = 114 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 54/235 (22%), Positives = 84/235 (35%), Gaps = 61/235 (25%) Query: 8 RRVLVTGAGKGIGRGTVQALHAT--GARVVAV----SRTQADLDSLVRECPGIEPVCVDL 61 R LVTGA +GIG + L G VV +R QA + L E +D+ Sbjct: 3 RVALVTGANRGIGLAIARELCRQFSG-DVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 61 Query: 62 GDWEATER----ALGSVGPVDLLVNNAAVA-LLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 D ++ G +++LVNNAAVA + +A + + + N A + Sbjct: 62 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-EMTLKTNFFATRNMCN 120 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTN------------------------------- 145 + + G +VN+SS RA N Sbjct: 121 ELLPIMKPH---GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 177 Query: 146 ----------HSVYCSTKGALDMLTKVMALELGPH----KIRVNAVNPTVVMTSM 186 +S Y +K + +L++++A L +I VNA P V T M Sbjct: 178 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 232 >3F4B-A nrPDB Length = 323 Score = 112 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 40/204 (19%), Positives = 78/204 (38%), Gaps = 29/204 (14%) Query: 64 WEATERALGSVGPVDLLVNNAAVALL--QPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 E G + +LV++ A + L+ +++ + + + ++I + + + Sbjct: 108 EEVANLIYNKYGKISMLVHSLANGREVQKSLLDTSRDGYLDAISKSSYSLISLCKHFCKF 167 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELG-PHKIRVNAVNP 179 + G++V+++ Q SQ+ V + S K AL+ T+V+A LG + IR+N ++ Sbjct: 168 M---NSGGSVVSLTYQASQKVVPGYGGGMSSAKAALESDTRVLAYYLGRKYNIRINTISA 224 Query: 180 TVVMTSMGQATWSD----------------------PHKAKTMLNRIPLGKFAEVEHVVN 217 + + A + PL K V + Sbjct: 225 GPLKSRAATAINKFNNNQKNNMNSSGETDKQNYSFIDYAIDYSEKYAPLKKKLLSTDVGS 284 Query: 218 AILFLLSDRSGMTTGSTLPVEGGF 241 FLLS S TG T+ V+ G Sbjct: 285 VASFLLSKESSAVTGQTIYVDNGL 308 >1OAA-A nrPDB Length = 259 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 54/218 (24%), Positives = 93/218 (42%), Gaps = 26/218 (11%) Query: 9 RVLVTGAGKGIGRGTVQALHAT---GARVVAVSRTQADLDSLVRECPGIEP------VCV 59 ++TGA +G GR L G+ ++ +R+++ L L E +P Sbjct: 8 VCVLTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAA 67 Query: 60 DLGDWEATERALGSVGPVD--------LLVNNAAV--ALLQPFLEVTK-EAFDRSFEVNL 108 DLG +R L +V + LL+NNAA + + FL V + + +NL Sbjct: 68 DLGTEAGVQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALNL 127 Query: 109 RAVIQVSQIVARGLI-ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 +++ ++ + G+ +VN+SS C+ + +YC+ K A DML +V+A E Sbjct: 128 TSMLCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAE- 186 Query: 168 GPHKIRVNAVNPTVVMTSMGQ---ATWSDPHKAKTMLN 202 +RV + P + M Q T DP + Sbjct: 187 -EPSVRVLSYAPGPLDNDMQQLARETSKDPELRSKLQK 223 >2NTV-A nrPDB Length = 268 Score = 108 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 51/264 (19%), Positives = 97/264 (36%), Gaps = 31/264 (11%) Query: 4 FLAGRRVLVTGA--GKGIGRGTVQALHATGARVVAVSRTQADL-DSLVRECPGIEP-VCV 59 L G+R+LV+G I + GA++V + L + P P + + Sbjct: 3 LLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPLIEL 62 Query: 60 DLGDWE----ATERALGSVG---PVDLLVNNAAVAL-----LQPFLEVTKEAFDRSFEVN 107 D+ + E ER +G +D +V++ F + E + ++ Sbjct: 63 DVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIHIS 122 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALEL 167 + +++ + + G+IV + RA+ ++ K AL+ + + +A E Sbjct: 123 TYSYASLAKALLLIM---NSGGSIVGM-DFDPTRAMPAYNWMTVAKSALESVNRFVAREA 178 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSD----------PHKAKTMLNRIPLG-KFAEVEHVV 216 G + +R N V + T A + R P+G + V Sbjct: 179 GKYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVA 238 Query: 217 NAILFLLSDRSGMTTGSTLPVEGG 240 + LLS+ TTGS + +GG Sbjct: 239 KTVCALLSEWLPATTGSIIYADGG 262 >4OYR-A nrPDB Length = 289 Score = 108 bits (270), Expect = 2e-24, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 96/267 (35%), Gaps = 31/267 (11%) Query: 1 MELFLAGRRVLVTGA--GKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP-- 56 M L G+R+LV+G I + GA++V + L + + + Sbjct: 21 MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL 80 Query: 57 VCVDLGDWEATERALGSV-------GPVDLLVNNAAVAL-----LQPFLEVTKEAFDRSF 104 + +D+ + E G V +D +V++ + PF + + Sbjct: 81 LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI 140 Query: 105 EVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164 ++ + +++ + + G+IV + RA+ ++ K AL+ + + +A Sbjct: 141 HISAYSYASMAKALLPIM---NPGGSIVGM-DFDPSRAMPAYNWMTVAKSALESVNRFVA 196 Query: 165 LELGPHKIRVNAVNPTVVMTSMGQATWSD----------PHKAKTMLNRIPLG-KFAEVE 213 E G + +R N V + T A + R P+G + Sbjct: 197 REAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDAT 256 Query: 214 HVVNAILFLLSDRSGMTTGSTLPVEGG 240 V + LLSD TTG + +GG Sbjct: 257 PVAKTVCALLSDWLPATTGDIIYADGG 283 >5WQO-A nrPDB Length = 234 Score = 104 bits (259), Expect = 4e-23, Method: Composition-based stats. Identities = 49/189 (25%), Positives = 82/189 (43%), Gaps = 14/189 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSR---TQADLDSLVRECPG-IEPVCVDLGDWE 65 VL+ GA +GIG G A GA+V AV+R L +L ++ V DL + Sbjct: 9 VLIVGASRGIGLGLADAFLQRGAQVFAVARRPQGSPGLQALAERAGERLQAVTGDLNQHD 68 Query: 66 ATERALGSVG--PVDLLVNNAAV--ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 ER +G +D L+ NA + Q E+ E + F N A +++++ ++ Sbjct: 69 CAERIGEMLGERRIDRLIVNAGIYGPQQQDVAEIDAEQTAQLFLTNAIAPLRLARALSGR 128 Query: 122 LIARGVPGAIVNVSSQCSQRA---VTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 + G + +SSQ + A +Y ++K AL+ L + E + ++ Sbjct: 129 V---SRGGVVAFMSSQMASLALGLSATMPLYGASKAALNSLVRSWEGEFEELPFSLLLLH 185 Query: 179 PTVVMTSMG 187 P V T MG Sbjct: 186 PGWVRTEMG 194 >2O2Y-A nrPDB Length = 349 Score = 102 bits (255), Expect = 1e-22, Method: Composition-based stats. Identities = 38/225 (16%), Positives = 83/225 (36%), Gaps = 51/225 (22%) Query: 65 EATERALGS-VGPVDLLVNNAAVA--LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 E + G +++LV++ A A + + L +++ + + + ++I + + Sbjct: 113 EDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNI 172 Query: 122 LIARGVPGAIVNVSSQCSQRAVTNHSV-YCSTKGALDMLTKVMALELGP-HKIRVNAVNP 179 + + +I++++ SQ+ V + S K AL+ T+V+A LG + IR+N ++ Sbjct: 173 MKPQS---SIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISA 229 Query: 180 TVVMTSMGQAT----------------------------WSDPHKAKTMLNR-------- 203 + + A + + K ++ Sbjct: 230 GPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYA 289 Query: 204 -------IPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGF 241 PL + + + FLLS S TG T+ V+ G Sbjct: 290 IEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGL 334 >3BHI-A nrPDB Length = 276 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 89/282 (31%), Gaps = 78/282 (27%) Query: 9 RVLVTGAGKGIGRGTVQALHA--TGARVVAVS----RTQADLDSLVRECPGIEPVCVDLG 62 LVTG KGIG V+ L +G VV + R QA + L E +D+ Sbjct: 6 VALVTGGNKGIGLAIVRDLCRLFSG-DVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDID 64 Query: 63 DWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 D ++ G +D+LVNNA +A + + + N V + Sbjct: 65 DLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTEL 124 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAV----------------------------------- 143 + + G +VNVSS S RA+ Sbjct: 125 LPLIKPQ---GRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKG 181 Query: 144 ------TNHSVYCSTKGALDMLTKVMALELGPH----KIRVNAVNPTVVMTSMGQATWSD 193 S Y TK + +L+++ A +L KI +NA P V T M + Sbjct: 182 VHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDM-----AG 236 Query: 194 PHKAKTMLNRIPLGKFAEVEHVVNAILFLL--SDRSGMTTGS 233 P K E ++L + G Sbjct: 237 PKATK------------SPEEGAETPVYLALLPPDAEGPHGQ 266 >1N5D-A nrPDB Length = 288 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 60/238 (25%), Positives = 86/238 (36%), Gaps = 65/238 (27%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGA-RVVAV----SRTQADLDSLVRECPGIEPVCVDLG 62 R LVTGA KGIG V+ L A VV +R QA + L E +D+ Sbjct: 5 RVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQLDII 64 Query: 63 DWEATER----ALGSVGPVDLLVNNAAVA----LLQPFLEVTKEAFDRSFEVNLRAVIQV 114 D ++ G +D+LVNNAA+A PF + E + + N V Sbjct: 65 DLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPF-HIQAE---LTMKTNFMGTRNV 120 Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAV------------------------------- 143 + + + G +VNVSS RA+ Sbjct: 121 CTELLPLIKPQ---GRVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVED 177 Query: 144 ----------TNHSVYCSTKGALDMLTKVMALEL----GPHKIRVNAVNPTVVMTSMG 187 + S Y TK + +L+++ A +L KI +NA P V T MG Sbjct: 178 TKNGVHRKEGWSDSTYGVTKIGVSVLSRIYARKLREQRAGDKILLNACCPGWVRTDMG 235 >3U9L-A nrPDB Length = 324 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 44/193 (22%), Positives = 89/193 (46%), Gaps = 15/193 (7%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVA-----VSRTQADLDSLV----RECPG 53 + ++ + +L+TGA G GR T +AL G RV A V R ++++++ Sbjct: 1 MVMSKKIILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARDNDVD 60 Query: 54 IEPVCVDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109 + + +D+ + +RA+ + G +D+L++NA + P T E F +++N+ Sbjct: 61 LRTLELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELYDINVL 120 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNH-SVYCSTKGALDMLTKVMALELG 168 + +V++ + R G ++ +SS S + + Y + K A+D + A EL Sbjct: 121 STQRVNRAALPHM-RRQKHGLLIWISSSSSAGGTPPYLAPYFAAKAAMDAIAVQYARELS 179 Query: 169 PHKIRVNAVNPTV 181 I + + P Sbjct: 180 RWGIETSIIVPGA 192 >5L51-A nrPDB Length = 324 Score = 100 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 94/289 (32%), Gaps = 95/289 (32%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ----ADLDSLVRECPG-----IEP 56 R +VTGA KGIG + L + G V+ SR + + L++E + Sbjct: 14 TKRYAVVTGANKGIGFEICKQLASKGITVILASRDEKRGIEARERLIKELGSEFGDYVVS 73 Query: 57 VCVDLGDWEATERALG----SVGPVDLLVNNAAV---------ALLQPFLEVTKEAFD-- 101 +D+ D + + G +D+LVNNA + ++L ++E + F Sbjct: 74 QQLDVADPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDYVEAEFKTFQSG 133 Query: 102 -----------------------RSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQC 138 E N +V++ + L P IVNVSS Sbjct: 134 AAKTEPYHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDSP-RIVNVSSTL 192 Query: 139 SQRAV-------------------------------------------TNHSVYCSTKGA 155 S + S Y +K A Sbjct: 193 SSLVFQTNEWAKGVFSSEEGLTEEKLEEVLAEFLKDFIDGKQQEKQWPPHFSAYKVSKAA 252 Query: 156 LDMLTKVMALELGPHKIRVNAVNPTVVMTSM--GQATWSDPHKAKTMLN 202 L+ T+++A + R+NAV P T + G ++D A+ + Sbjct: 253 LNAYTRIIAKKYPSF--RINAVCPGYTKTDLSYGHGQFTDAEAAEAPVK 299 >1B15-A nrPDB Length = 254 Score = 97.9 bits (243), Expect = 3e-21, Method: Composition-based stats. Identities = 39/199 (19%), Positives = 77/199 (38%), Gaps = 24/199 (12%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGAR-VVAVSRTQ-----ADLDSLVRECPGIEP 56 + L + V+ A GIG T + L + V + R + A+L ++ + I Sbjct: 1 MDLTNKNVIFVAALGGIGLDTSRELVKRNLKNFVILDRVENPTALAELKAINPKV-NITF 59 Query: 57 VCVDLG-----DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 D+ + ++ + VD+L+N A + + +R+ +N + Sbjct: 60 HTYDVTVPVAESKKLLKKIFDQLKTVDILINGAGI--------LDDHQIERTIAINFTGL 111 Query: 112 IQVSQIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + + R G G I N+ S A+ VY ++K A+ T +A L P Sbjct: 112 VNTTTAILDFWDKRKGGPGGIIANICSVTGFNAIHQVPVYSASKAAVVSFTNSLAK-LAP 170 Query: 170 -HKIRVNAVNPTVVMTSMG 187 + ++NP + T + Sbjct: 171 ITGVTAYSINPGITRTPLV 189 >3O26-A nrPDB Length = 311 Score = 91.0 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 55/268 (20%), Positives = 86/268 (32%), Gaps = 86/268 (32%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP-----GIEPVCVDLG 62 R +VTG KGIG + L + G VV R V + + +D+ Sbjct: 13 RCAVVTGGNKGIGFEICKQLSSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQLDVT 72 Query: 63 DWEATERALGS-----VGPVDLLVNNAAVA------------------------------ 87 D AT +L G +D+LVNNA VA Sbjct: 73 DPIATMSSLADFIKTHFGKLDILVNNAGVAGFSVDADRFKAMISDIGEDSEELVKIYEKP 132 Query: 88 LLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNH- 146 Q + T E + ++N V V++++ L P IVNVSS ++ Sbjct: 133 EAQELMSETYELAEECLKINYNGVKSVTEVLIPLLQLSDSP-RIVNVSSSTGSLKYVSNE 191 Query: 147 ------------------------------------------SVYCSTKGALDMLTKVMA 164 + Y ++K L+ T+V+A Sbjct: 192 TALEILGDGDALTEERIDMVVNMLLKDFKENLIETNGWPSFGAAYTTSKACLNAYTRVLA 251 Query: 165 LELGPHKIRVNAVNPTVVMTSMGQATWS 192 ++ + VN V P +V T M + Sbjct: 252 NKIPKFQ--VNCVCPGLVKTEMNYGIGN 277 >1MG5-A nrPDB Length = 255 Score = 89.4 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 78/219 (35%), Gaps = 26/219 (11%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGAR-VVAVSR--TQADLDSLVRECPGIEP-- 56 L + V+ GIG T + L + +V + R A + L P + Sbjct: 1 SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTF 60 Query: 57 VCVDLGDW-----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 D+ + + + VD+L+N A + + +R+ VN + Sbjct: 61 YPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGI--------LDDHQIERTIAVNYTGL 112 Query: 112 IQVSQIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + + R G G I N+ S A+ VY TK A+ T +A L P Sbjct: 113 VNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAK-LAP 171 Query: 170 -HKIRVNAVNPTVVMTSMGQATWS----DPHKAKTMLNR 203 + VNP + T++ S +P A+ +L Sbjct: 172 ITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAH 210 >5TQV-A nrPDB Length = 233 Score = 89.4 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 11/188 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 + VL+ GA +G+GR V+ G V+A +R A L +L G +D+ E Sbjct: 10 KTVLIVGASRGLGREFVRQYQRDGWNVIATARDDASLAAL--RALGAHAHALDITQPEQI 67 Query: 68 ERALGSVG--PVDLLVNNAAV--ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + +D+ V + V + + + FD N+R +Q+ I+ + Sbjct: 68 AALGWKLDGERLDVAVVVSGVYGPRTEGVETIASDDFDTVMHTNVRGPMQLLPILLPLVE 127 Query: 124 ARGVPGAIVN--VSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTV 181 A+V+ + S T +Y ++K AL+ + ++ + L +++P Sbjct: 128 DARGVLAVVSSRMGSISEATGTTGW-LYRASKAALNDVLRIAS--LQTRHAACISLHPGW 184 Query: 182 VMTSMGQA 189 V T MG A Sbjct: 185 VRTDMGGA 192 >5LCX-A nrPDB Length = 316 Score = 75.2 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 31/116 (26%), Positives = 49/116 (42%), Gaps = 14/116 (12%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD--------LDSLVRECPGIEPVCV 59 R LVTGA KGIG + L G V+ SR + L L + + Sbjct: 8 RYALVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQL 67 Query: 60 DLGDWEATER----ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 D+ D + G +D+LVNNA V+ ++ +V+ F+ E + +A+ Sbjct: 68 DVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSV--FNEYIEADFKAL 121 Score = 37.4 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%), Gaps = 2/44 (4%) Query: 144 TNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMG 187 + + +K AL+ TK+ A + R+NA+ P T + Sbjct: 235 PHFAAERVSKAALNAYTKIAAKKYPSF--RINAICPGYAKTDIT 276 >2PK3-A nrPDB Length = 321 Score = 66.3 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 88/260 (33%), Gaps = 48/260 (18%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 R L+TG +G+ L V SR + P +E + +D+ D + + Sbjct: 14 RALITGVAGFVGKYLANHLTEQNVEVFGTSRNNE------AKLPNVEMISLDIMDSQRVK 67 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAF---DRSFEVNLRAVIQVSQIVARGLIAR 125 + + + P D + + AA + ++ +++ +F N+ + V V Sbjct: 68 KVISDIKP-DYIFHLAAKSSVK-------DSWLNKKGTFSTNVFGTLHVLDAVRDS---- 115 Query: 126 GVPGAIVNVSS-------------QCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172 + I+ + S + + S Y +K ++ ML + G I Sbjct: 116 NLDCRILTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAYGMDII 175 Query: 173 ---RVNAVNP----TVVMTSMGQATWSDPHKAKTMLNRI----PLGKFAEVEHVVNAILF 221 N + P V + + + + ++ + F +V +V A + Sbjct: 176 HTRTFNHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAY-W 234 Query: 222 LLSDRSGMTTGSTLPVEGGF 241 LLS TG V G Sbjct: 235 LLSQYGK--TGDVYNVCSGI 252 >3SLK-A nrPDB Length = 795 Score = 64.4 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 36/186 (19%), Positives = 58/186 (31%), Gaps = 30/186 (16%) Query: 9 RVLVTGAGKGIGRGTVQALH-ATGAR-VVAVSRTQADLDSLVRECPGIEPV-------CV 59 VLVTG +G + L G R +V VSR + Sbjct: 532 TVLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQAC 591 Query: 60 DLGDWEATERALGSVG---PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116 D+ D E + L S+ P+ +V+ A V +T E D+ + + + Sbjct: 592 DVADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLLE 651 Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDML----------TKVMALE 166 ++ + A+V SS Y + LD L T+ +A Sbjct: 652 LIDPDV-------ALVLFSSVSGVLGSGGQGNYAAANSFLDALAQQRQSRGLPTRSLAWG 704 Query: 167 -LGPHK 171 H Sbjct: 705 PWAEHG 710 >3RFT-A nrPDB Length = 267 Score = 61.3 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 62/166 (37%), Gaps = 33/166 (19%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 +R+LVTGA +GR + L A ++ + ADL L P E V DL D A Sbjct: 4 KRLLVTGAAGQLGRVMRERLAPM-AEILRL----ADLSPLDPAGPNEECVQCDLADANAV 58 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 + D +V+ +++ +P F++ + N+ + + + A G Sbjct: 59 NAMVA---GCDGIVHLGGISVEKP--------FEQILQGNIIGLYNLYEAA----RAHGQ 103 Query: 128 PGAIVNVSSQCSQRAVTNH------------SVYCSTKGALDMLTK 161 P IV SS + +Y +K + L + Sbjct: 104 P-RIVFASSNHTIGYYPQTERLGPDVPARPDGLYGVSKCFGENLAR 148 >4LIS-A nrPDB Length = 371 Score = 60.9 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 36/168 (21%), Positives = 64/168 (38%), Gaps = 29/168 (17%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVS---RTQADLDSLVRECPG--IEPVCVDLGDW 64 VLVTG IG T AL G +VV + A+ + + G E +D+ D Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTDE 65 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 A ++ + +D +++ AA+ + + E + VN+ I + + + R + Sbjct: 66 AAFDKVFEAHPDIDSVIHFAALKAVGE----SGEKPLDYYHVNVYGTICLLRSMVRHNVT 121 Query: 125 RGVPGAIVNVSSQCS---------QRAVTNH------SVYCSTKGALD 157 IV SS + H + Y +TK A++ Sbjct: 122 N-----IVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAIE 164 >2Q1W-A nrPDB Length = 333 Score = 58.2 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 60/187 (32%), Gaps = 35/187 (18%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 ++V +TG IG + L G +VV + +++ P + V + D Sbjct: 22 KKVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRREHLKDHPNLTFVEGSIADHALV 81 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 + +G + P D +V+ AA + + N V Q + Sbjct: 82 NQLIGDLQP-DAVVHTAASYKD-------PDDWYNDTLTNCVGGSNVVQAA-----KKNN 128 Query: 128 PGAIVNVSSQC--SQRA-----------VTNHSVYCSTKGA---------LDMLTKVMAL 165 G V + + +S Y +K A LD +T +A Sbjct: 129 VGRFVYFQTALCYGVKPIQQPVRLDHPRNPANSSYAISKSANEDYLEYSGLDFVTFRLAN 188 Query: 166 ELGPHKI 172 +GP + Sbjct: 189 VVGPRNV 195 >3ORF-A nrPDB Length = 251 Score = 57.5 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 66/213 (30%), Gaps = 31/213 (14%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECPGIEPVCVDLGDWEA 66 + +LV G +G V+ + +++ R + D + E Sbjct: 23 KNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNAD---------HSFTIKDSGEEE 73 Query: 67 TERALGSVG----PVDLLVNNAAVALLQPFLEVTKEAF----DRSFEVNLRAVIQVSQIV 118 + + + VD V A + + F ++NL + + I Sbjct: 74 IKSVIEKINSKSIKVDTFVCAAGGWSGG---NASSDEFLKSVKGMIDMNLYSAFASAHIG 130 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG--PHKIRVNA 176 A+ L G V + + + Y +TK A + K +A E G P Sbjct: 131 AKLL---NQGGLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENGGLPAGSTSLG 187 Query: 177 VNPTVVMTS-----MGQATWSDPHKAKTMLNRI 204 + P + T M A + D + ++ Sbjct: 188 ILPVTLDTPTNRKYMSDANFDDWTPLSEVAEKL 220 >6BWL-A nrPDB Length = 328 Score = 57.5 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 38/263 (14%), Positives = 80/263 (30%), Gaps = 46/263 (17%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ----ADLDSLVRECPGIEPVCVDLGDW 64 ++LVTG IGR V+ L V + A++ + + + D+ D Sbjct: 2 KILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQCIQGDIKDK 61 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG--- 121 + + + DL + AA +Q + + +FE + + + Sbjct: 62 KLVAQLFEN-NSFDLCYHLAASINVQD----SIDDARATFENDTIGTFNLLEQCLNYDVK 116 Query: 122 ---LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVN 178 + V N+ + S Y +K A + + +K+ V + Sbjct: 117 MVFMSTCMVYDKATNIQGISELDPIKPASPYAGSKIAAENMVLSY---YYAYKLPVVVIR 173 Query: 179 PTVVMTSMGQATWSDPHKA---KTMLNRIPLGKFAE---------VEHVVNAILFLLSDR 226 P + A L+ +PL + + VE + ++ Sbjct: 174 PFNTYGPFQKTGGEGGVVAIFINNKLDNVPLNIYGDGKQTRDLLYVEDCADFVV-----A 228 Query: 227 SGMT-----------TGSTLPVE 238 +G + TG + + Sbjct: 229 AGYSAKANGHIINAGTGQDISIN 251 >1OOE-A nrPDB Length = 236 Score = 54.4 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 65/189 (34%), Gaps = 11/189 (5%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 +G+ + V G +G ++ G V+ + + D G + + Sbjct: 3 SGKVI-VYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADSNILVDGNKNWT--EQEQS 59 Query: 66 ATERALGSVGP--VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 E+ S+ VD + A + + F ++ ++ ++ + S I A+ Sbjct: 60 ILEQTASSLQGSQVDGVFCVAGGWAGG---SASSKDFVKNADLMIKQSVWSSAIAAKLAT 116 Query: 124 ARGVPGAIVNVSSQCSQRA-VTNHSVYCSTKGALDMLTKVMAL--ELGPHKIRVNAVNPT 180 PG ++ ++ + + Y K A+ LT +A P V + P Sbjct: 117 THLKPGGLLQLTGAAAAMGPTPSMIGYGMAKAAVHHLTSSLAAKDSGLPDNSAVLTIMPV 176 Query: 181 VVMTSMGQA 189 + T M + Sbjct: 177 TLDTPMNRK 185 >2PZM-A nrPDB Length = 330 Score = 54.0 bits (129), Expect = 5e-08, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 57/162 (35%), Gaps = 24/162 (14%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 R+L+TG +G ++ G ++ + ++ G+ + + D E Sbjct: 22 RILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGLSVIEGSVTDAGLLE 81 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR--- 125 RA S P + V++AA + + N++ I V++ ++ + R Sbjct: 82 RAFDSFKPTHV-VHSAAAYKD-------PDDWAEDAATNVQGSINVAKAASKAGVKRLLN 133 Query: 126 -------GVPGAI-VNVSSQCSQRAVTNHSVYCSTKGALDML 159 G P + + + S + Y +K A + Sbjct: 134 FQTALCYGRPATVPIPIDS-----PTAPFTSYGISKTAGEAF 170 >1UDA-A nrPDB Length = 338 Score = 52.4 bits (125), Expect = 1e-07, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 55/157 (35%), Gaps = 17/157 (10%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVS---RTQADLDSLVRECPGIEP--VCVDLGD 63 RVLVTG IG T L G V+ + ++ + ++ G P V D+ + Sbjct: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 L +D +++ A + + ++ E +D N+ +++ + + Sbjct: 62 EALMTEILHDH-AIDTVIHFAGLKAVGESVQKPLEYYDN----NVNGTLRLISAMRAANV 116 Query: 124 ARGVPGAIVN-------VSSQCSQRAVTNHSVYCSTK 153 + + + S T S Y +K Sbjct: 117 KNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSK 153 >1DIR-A nrPDB Length = 241 Score = 52.1 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 66/212 (31%), Gaps = 26/212 (12%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 M RRVLV G +G VQA A V ++ + E V + Sbjct: 1 MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVE------NEEASASVIVKMT 54 Query: 61 LGDWEATERALGSVGPV------DLLVNNAA-----VALLQPFLEVTKEAFDRSFEVNLR 109 E ++ VG + D ++ A A + + + +S + Sbjct: 55 DSFTEQADQVTAEVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTI 114 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA--LEL 167 + ++ + G + ++ + Y KGA+ L + +A Sbjct: 115 SSHLATKHL-------KEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSG 167 Query: 168 GPHKIRVNAVNPTVVMTSMGQATWSDPHKAKT 199 P AV P + T M + + + + Sbjct: 168 MPSGAAAIAVLPVTLDTPMNRKSMPEADFSSW 199 >2GN9-A nrPDB Length = 344 Score = 50.9 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 62/154 (40%), Gaps = 19/154 (12%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQA-LHATGA-RVVAVSRTQADLDSLVREC--PGIEPVCV 59 L + +L+TG G+ V+ L T A +++ SR + + E P + Sbjct: 18 MLDNQTILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAMEFNDPRMRFFIG 77 Query: 60 DLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 D+ D E AL VD+ ++ AA+ + P E + N+ V Sbjct: 78 DVRDLERLNYALE---GVDICIHAAALKHV-PIAEYNP---LECIKTNIMGASNVINACL 130 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTK 153 + I++ ++ +S+ + + ++Y +TK Sbjct: 131 KNAISQ-----VIALSTDKAANPI---NLYGATK 156 >4G5H-A nrPDB Length = 363 Score = 50.1 bits (119), Expect = 7e-07, Method: Composition-based stats. Identities = 22/158 (13%), Positives = 57/158 (36%), Gaps = 18/158 (11%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVRECPG--IEPVCV 59 + + +L+TG G ++ + + SR + D + ++ ++ Sbjct: 21 MGFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIG 80 Query: 60 DLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 D+ D ++ E A+ V D + + AA+ + EA N+ V Q Sbjct: 81 DVRDSQSVETAMRDV---DYVFHAAALKQVPSCEFFPVEAVK----TNIIGTENVLQSAI 133 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALD 157 + + ++ +S+ + + + +K ++ Sbjct: 134 HQNVKK-----VICLSTDKAAYPI---NAMGISKAMME 163 >1Z45-A nrPDB Length = 699 Score = 50.1 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 61/168 (36%), Gaps = 24/168 (14%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ-------ADLDSLVRECPGIEPVCVD 60 + VLVTG IG TV L G V A L+ L + I VD Sbjct: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH--IPFYEVD 69 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 L D + E+ +D +++ A + + ++ R + N+ + + +++ + Sbjct: 70 LCDRKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPL----RYYHNNILGTVVLLELMQQ 124 Query: 121 GLIAR----------GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDM 158 +++ G N+ + + + Y TK A++ Sbjct: 125 YNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIEN 172 >1WVG-A nrPDB Length = 359 Score = 49.4 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 24/164 (14%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ---ADLDSLVRECPGIEPVCVDLG 62 G+RV VTG G L GA V + L +VR +E D+ Sbjct: 8 QGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRLNDLMESHIGDIR 67 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 D+E ++ P +++ + AA QP + ++ E +++ N+ + + + V Sbjct: 68 DFEKLRSSIAEFKP-EIVFHMAA----QPLVRLSYEQPIKTYSTNVMGTVHLLETV---- 118 Query: 123 IARGVPGAIVNVSS---------QCSQR---AVTNHSVYCSTKG 154 G A+VN++S R + + Y ++KG Sbjct: 119 KQVGNIKAVVNITSDKCYDNREWVWGYRENEPMGGYDPYSNSKG 162 >4PVC-A nrPDB Length = 342 Score = 48.6 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 26/138 (18%), Positives = 52/138 (37%), Gaps = 18/138 (13%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVDLGDWE 65 V V+GA I + V L +V+ +R+Q ++L V D+ + Sbjct: 3 VFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTEAFGNNPKFSMEVVPDISKLD 62 Query: 66 ATERALGSVGP-VDLLVNNAAVALLQPF-LEVTKEAFDRSF-EVN-LRAVIQVSQIVARG 121 A + G + ++++ A PF ++T D VN ++ ++ + A Sbjct: 63 AFDHVFQKHGKDIKIVLHTA-----SPFCFDITDSERDLLIPAVNGVKGILHSIKKYAAD 117 Query: 122 LIARGVPGAIVNVSSQCS 139 + +V SS + Sbjct: 118 SVE-----RVVLTSSYAA 130 >1VL0-A nrPDB Length = 292 Score = 47.4 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 25/166 (15%), Positives = 53/166 (31%), Gaps = 39/166 (23%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 ++L+TGA +GR + L V+ +D+ + A Sbjct: 14 KILITGANGQLGREIQKQLKGKNVEVIPTDVQD-----------------LDITNVLAVN 56 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVP 128 + ++++N AA ++ +E +D ++++N ++ V Sbjct: 57 KFFNE-KKPNVVINCAAHT----AVDKCEEQYDLAYKINAIGPKNLAAAAY------SVG 105 Query: 129 GAIVNVSSQCSQRAVT-----------NHSVYCSTKGALDMLTKVM 163 IV +S+ S Y TK + K + Sbjct: 106 AEIVQISTDYVFDGEAKEPITEFDEVNPQSAYGKTKLEGENFVKAL 151 >1RKX-A nrPDB Length = 357 Score = 46.7 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 42/199 (21%), Positives = 74/199 (37%), Gaps = 32/199 (16%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 G+RV VTG G L GA V S T + SL + + ++GD Sbjct: 8 QGKRVFVTGHTGFKGGWLSLWLQTMGATVKGYSLTAPTVPSLFETARVADGMQSEIGDIR 67 Query: 66 ATERALGSVGPV--DLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + L S+ +++ + AA QP + ++ ++ N+ + + + + Sbjct: 68 DQNKLLESIREFQPEIVFHMAA----QPLVRLSYSEPVETYSTNVMGTVYLLEAI----- 118 Query: 124 ARGVPG--AIVNVSS---------QCSQR---AVTNHSVYCSTKGALDMLTKVMA----- 164 R V G A+VN++S R A+ + Y ++KG +++T Sbjct: 119 -RHVGGVKAVVNITSDKCYDNKEWIWGYRENEAMGGYDPYSNSKGCAELVTSSYRNSFFN 177 Query: 165 -LELGPHKIRVNAVNPTVV 182 G H V V V Sbjct: 178 PANYGQHGTAVATVRAGNV 196 >4J2O-A nrPDB Length = 363 Score = 45.5 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 74/233 (31%), Gaps = 37/233 (15%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVRECPGI--EPVCVD 60 + +L+TG G ++ T + SR + D + ++ + D Sbjct: 20 MFKDKVLLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKKYHSAKLKFYIGD 79 Query: 61 LGDWEATERALGSVGPVDLLVNNAAV--ALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 + D+ + L + VD + + AA+ F + + + N+ V + Sbjct: 80 VRDYNSI---LNATRGVDYIYHAAALKQVPSCEFHPM------EAVKTNVLGTENVLEAA 130 Query: 119 ARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALD--MLTKVMALELGPHKIRVNA 176 + + +V +S+ + + + +K ++ M+ K LE Sbjct: 131 IQNHVK-----RVVCLSTDKAVYPI---NAMGISKAMMEKVMVAKSRNLEGLDT-----V 177 Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIPL--------GKFAEVEHVVNAILF 221 + T M P + PL +E V+ +L+ Sbjct: 178 ICGTRYGNVMASRGSVIPLFVDQIRQGKPLTITDPNMTRFMMTLEDAVDLVLY 230 >1I3M-A nrPDB Length = 348 Score = 45.5 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 34/179 (18%), Positives = 63/179 (35%), Gaps = 35/179 (19%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVS------RTQADLDSLVRECP-----GIEPV 57 +VLVTG IG TV L G V + R L +R +E Sbjct: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 Query: 58 CVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 +D+ D A +R +++ A + + ++ + + VNL IQ+ +I Sbjct: 64 EMDILDQGALQRLFKKY-SFMAVIHFAGLKAMGESVQKPLD----YYRVNLTGTIQLLEI 118 Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNH-------------SVYCSTKGALDMLTKVM 163 + A GV + SS + + + Y +K ++ + + + Sbjct: 119 ----MKAHGVKN--LVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDL 171 >4KTT-E nrPDB Length = 327 Score = 44.4 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 49/135 (36%), Gaps = 21/135 (15%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 E+ + RRVLVTGA +GR + V +A + V+L Sbjct: 16 EVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRAR----------PKFEQVNL 65 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 D A + P ++V+ AA D + ++N+ A +++ A Sbjct: 66 LDSNAVHHIIHDFQP-HVIVHCAAERRPDVVENQP----DAASQLNVDASGNLAKEAA-- 118 Query: 122 LIARGVPGAIVNVSS 136 V ++ +SS Sbjct: 119 ----AVGAFLIYISS 129 >1GY8-A nrPDB Length = 397 Score = 43.6 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 55/161 (34%), Gaps = 32/161 (19%) Query: 9 RVLVTGAGKGIGRGTVQALHAT-GARVVAVS------------RTQADLDSLVRECPGIE 55 RVLV G IG V+AL VV V T+ ++ +++ G + Sbjct: 4 RVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPK 63 Query: 56 P---------VCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV 106 P D+ + + GP+D +V+ A + + + +D Sbjct: 64 PPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDN---- 119 Query: 107 NLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHS 147 N+ ++++ Q + + I+ SS + Sbjct: 120 NVVGILRLLQAMLLHKCDK-----IIF-SSSAAIFGNPTMG 154 >3SC6-A nrPDB Length = 287 Score = 43.2 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 23/166 (13%), Positives = 61/166 (36%), Gaps = 39/166 (23%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 RV++TGA +G+ + Q +L+ + + +D+ + + Sbjct: 7 RVIITGANGQLGK-----------------QLQEELNPEEYDIYPFDKKLLDITNISQVQ 49 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVP 128 + + + ++++ AA ++ ++ D ++ +N V VA L+ Sbjct: 50 QVVQEI-RPHIIIHCAAYTK----VDQAEKERDLAYVINAIGARNV--AVASQLV----G 98 Query: 129 GAIVNVSSQCSQRA-----------VTNHSVYCSTKGALDMLTKVM 163 +V +S+ + ++Y ++K A + K + Sbjct: 99 AKLVYISTDYVFQGDRPEGYDEFHNPAPINIYGASKYAGEQFVKEL 144 >2NNL-D nrPDB Length = 337 Score = 42.8 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 82/247 (33%), Gaps = 45/247 (18%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC------VDLG 62 V VTGA IG V L G V A R ++ + + DL Sbjct: 7 TVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLA 66 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 D + + A+ + + VA F E + + + ++ + + A Sbjct: 67 DEGSFDEAIK---GCTGVFH---VATPMDFESKDPE--NEVIKPTIEGMLGIMKSCA--- 115 Query: 123 IARGVPGAIVNVSSQCSQRAVTNH-SVY----------CSTK---GALDMLTKVMALELG 168 A +V SS + + VY C K + ++K +A + Sbjct: 116 -AAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAA 174 Query: 169 -----PHKIRVNAVNPT-----VVMTSMGQAT---WSDPHKAKTMLNRIPLGKFAEVEHV 215 + I + PT +M+SM + S + + I G+F ++ + Sbjct: 175 WKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDL 234 Query: 216 VNAILFL 222 NA ++L Sbjct: 235 CNAHIYL 241 >5K1S-A nrPDB Length = 362 Score = 42.4 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 1/76 (1%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 AG VL+TGA G+G +VQ GARV+AV+ ++A + +L V L Sbjct: 183 AGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFAS 242 Query: 66 ATERALGSVGPVDLLV 81 + G VD+ V Sbjct: 243 DVRKRTQGAG-VDVAV 257 >5B6K-A nrPDB Length = 366 Score = 42.4 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 44/139 (31%), Gaps = 14/139 (10%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD---LDSLVRECPGIEP-VCVDLGDW 64 V V+GA I + V+ L +V+ R+ L +++ + + D+ D Sbjct: 23 TVFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIFKGGDFNYEIVKDISDP 82 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 A + G D+ V V ++ L + ++ + + Sbjct: 83 TAFDHVFEKHGK-DIKV----VLHTASPFHFNTTDIEKDL---LIPAVNGTKGILESIKK 134 Query: 125 --RGVPGAIVNVSSQCSQR 141 +V SS + Sbjct: 135 YAAQTVERVVVTSSFAANT 153 >1ZZE-A nrPDB Length = 342 Score = 42.0 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 50/141 (35%), Gaps = 9/141 (6%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 G VLVTGA + V+ L G +V +R+ + L +L + P + E Sbjct: 10 EGSLVLVTGANGFVASHVVEQLLEHGYKVRGTARSASKLANLQKRWDAKYPGRFETAVVE 69 Query: 66 ATERALGSVGPVDLLV-NNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 + G D ++ A VA + + + + +D + + + A Sbjct: 70 DMLKQ----GAYDEVIKGAAGVAHIASVVSFSNK-YDEVVTPAIGGTLNALRAAAATPSV 124 Query: 125 RGVPGAIVNVSSQCSQRAVTN 145 + ++ S+ + N Sbjct: 125 KRF---VLTSSTVSALIPKPN 142 >6GCS-E nrPDB Length = 375 Score = 41.7 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 48/122 (39%), Gaps = 13/122 (10%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ--ADLDSLVRECPGIEPVCVDLGD 63 G V GA +G L G VV R + + + + + +DL + Sbjct: 52 TGYTATVFGANGFLGSYLTAKLAKHGTTVVVPYREEMAKRHLKVTGDLGVVNFLEMDLRN 111 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 E+ + A+ D++VN E + F+ ++V++ ++++ V + I Sbjct: 112 LESIDEAVR---HSDIVVNLIG-------REYETKNFN-YYDVHVEGARRIAEAVKKHNI 160 Query: 124 AR 125 AR Sbjct: 161 AR 162 >2Z95-A nrPDB Length = 345 Score = 41.7 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 44/106 (41%), Gaps = 14/106 (13%) Query: 5 LAGRRVLVTGAGKGI-GRGTVQALHATGARVVAVSRTQAD-----LDSLVRECPGIEPVC 58 ++G+R L+TG +G G + L G V R + L L E ++ + Sbjct: 1 MSGKRALITGI-RGQDGAYLAKLLLEKGYEVYGADRRSGEFASWRLKELGIE-NDVKIIH 58 Query: 59 VDLGDWEATERALGSVGPVDLLVNNA-----AVALLQPFLEVTKEA 99 +DL ++ R + V P D + N A V+ QP L +A Sbjct: 59 MDLLEFSNIIRTIEKVQP-DEVYNLAAQSFVGVSFEQPILTAEVDA 103 >3ENK-A nrPDB Length = 341 Score = 40.9 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 5/70 (7%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVS---RTQADLDSLVRECPGIEP--VCVDLGD 63 +LVTG IG T L A G VV ++ + + + + G P D+ D Sbjct: 7 TILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSD 66 Query: 64 WEATERALGS 73 A R + Sbjct: 67 ERALARIFDA 76 >3NJ4-A nrPDB Length = 435 Score = 40.9 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 31/150 (20%), Positives = 57/150 (38%), Gaps = 15/150 (10%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ +AG+ +V G G +G+G QAL GARV+ +++L G E +D Sbjct: 211 DVMIAGKVAVVAGYGD-VGKGCAQALRGFGARVIITEIDP--INALQAAMEGYEVTTMDE 267 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV-----NLRAVIQVSQ 116 E + + G +D+++ + + FD +V N + + Sbjct: 268 ACQEG-NIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKP 326 Query: 117 IVARGLIARGVP------GAIVNVSSQCSQ 140 V R + G G +VN+ Sbjct: 327 QVDRYRLKNGRRIILLAEGRLVNLGCAMGH 356 >5F5N-A nrPDB Length = 289 Score = 40.5 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 24/70 (34%), Positives = 31/70 (44%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R +LVTGA G TV+AL A G V A+ R + G+ V DL D + Sbjct: 2 RTILVTGATGTQGGATVRALLARGRPVRALVRDPGTDAARALAAAGVSLVTGDLNDQASL 61 Query: 68 ERALGSVGPV 77 A+ V V Sbjct: 62 RAAMADVHGV 71 >5N2I-A nrPDB Length = 232 Score = 40.5 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 20/52 (38%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPV 57 +G + V G GRG + G V+ SR+ ++ E PV Sbjct: 18 SGLSIAVLGGTGDQGRGLARRFAMAGHEVILGSRSAERAQAVAAELGEGLPV 69 >6ACF-A nrPDB Length = 367 Score = 40.5 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 32/97 (32%), Gaps = 14/97 (14%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G+ V V G G + + LH GA+++ + + V E VD D Sbjct: 170 SLEGKVVAVQGVGN-VAYHLCRHLHEEGAKLIVTDINKEAVARAVEEFG---AKAVDPND 225 Query: 64 WEATERALGSVGPVDLLVNNA--AVALLQPFLEVTKE 98 E D+ A + Q ++ + Sbjct: 226 IYGVE--------CDIFAPCALGGIINDQTIPQLKAK 254 >4KDR-A nrPDB Length = 223 Score = 39.7 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 29/77 (37%), Gaps = 4/77 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G++VL G G GI +++ GA V + L + + + VD Sbjct: 60 GLFGKKVLDVGCGGGI---LAESMAREGATVTGLDMGFEPLQ-VAKLHALESGIQVDYVQ 115 Query: 64 WEATERALGSVGPVDLL 80 E A G D++ Sbjct: 116 ETVEEHAAKHAGQYDVV 132 >4KDC-A nrPDB Length = 246 Score = 39.7 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 29/77 (37%), Gaps = 4/77 (5%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G++VL G G GI +++ GA V + L + + + VD Sbjct: 60 GLFGKKVLDVGCGGGI---LAESMAREGATVTGLDMGFEPLQ-VAKLHALESGIQVDYVQ 115 Query: 64 WEATERALGSVGPVDLL 80 E A G D++ Sbjct: 116 ETVEEHAAKHAGQYDVV 132 >3SXP-A nrPDB Length = 362 Score = 39.7 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 62/199 (31%), Gaps = 38/199 (19%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATG--ARVVAVSR---------TQADLDSLVRECPG 53 L + +L+TG +G A+VV + + + + G Sbjct: 8 LENQTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIG 67 Query: 54 I--EPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111 E + D+ + R D L + AAV+ + T + + N +A Sbjct: 68 FKGEVIAADINNPLDLRRLEKL--HFDYLFHQAAVS------DTTMLNQELVMKTNYQAF 119 Query: 112 IQVSQIVARGLIARGVPGAIVNVSS--QCSQRAVTNH--------SVYCSTKGALDMLTK 161 + + + IAR ++ SS N +VY +K +D Sbjct: 120 LNLLE------IARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENVYGFSKLCMDEFVL 173 Query: 162 VMALELGPHKIR-VNAVNP 179 + + +R N P Sbjct: 174 SHSNDNVQVGLRYFNVYGP 192 >2C20-A nrPDB Length = 330 Score = 39.4 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 41/105 (39%), Gaps = 7/105 (6%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 +L+ G IG V+ L G VV V Q + + E G + DL D Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITE--GAKFYNGDLRDKAFLRD 61 Query: 70 ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 ++ +++ AA +L+ V+ E + + N+ + + Sbjct: 62 VFTQ-ENIEAVMHFAADSLVG----VSMEKPLQYYNNNVYGALCL 101 >2HUN-A nrPDB Length = 336 Score = 39.0 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 36/165 (21%), Positives = 62/165 (37%), Gaps = 24/165 (14%) Query: 11 LVTGAGKGIGRGTVQALHATG--ARVVAVSR-----TQADLDSLVRECPGIEPVCVDLGD 63 LVTG IG ++ + V+ + + A+L L + P V D+ D Sbjct: 7 LVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDD-PRYTFVKGDVAD 65 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR--- 120 +E + + VD +V+ AA + + + + E F N+ + + + R Sbjct: 66 YELVKELVR---KVDGVVHLAAESHVDRSIS-SPEIF---LHSNVIGTYTLLESIRRENP 118 Query: 121 -----GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLT 160 + V G I+ S + S Y +TK A DML Sbjct: 119 EVRFVHVSTDEVYGDILK-GSFTENDRLMPSSPYSATKAASDMLV 162 >1BXK-A nrPDB Length = 355 Score = 39.0 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 59/175 (33%), Gaps = 21/175 (12%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGAR-VVAVSRT--QADLDSLV--RECPGIEPVCVDLG 62 R++L+TG IG V+ + + VV V + +L SL + VD+ Sbjct: 2 RKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDIC 61 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122 D R P D +++ AA + + ++ AF + V +++ ++ L Sbjct: 62 DRAELARVFTEHQP-DCVMHLAAESHVDRSIDG-PAAFIETNIVGTYTLLEAARAYWNAL 119 Query: 123 IARGVPG---AIVNVSSQCS-----------QRAVTNHSVYCSTKGALDMLTKVM 163 ++ S Y ++K + D L + Sbjct: 120 TEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAW 174 >2EXX-A nrPDB Length = 306 Score = 39.0 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 25/71 (35%), Gaps = 1/71 (1%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 L + + V+V G G + L G +V V+R + G E V D Sbjct: 7 LMVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQ 66 Query: 62 GDWEATERALG 72 D E AL Sbjct: 67 DDQVIMELALN 77 >3HFS-A nrPDB Length = 338 Score = 38.6 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 20/140 (14%), Positives = 46/140 (32%), Gaps = 17/140 (12%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-----VRECPGIEPVCVDL 61 + V G + V+ L G V R + + ++E ++ DL Sbjct: 9 KKTACVVGGTGFVASLLVKLLLQKGYAVNTTVRDPDNQKKVSHLLELQELGDLKIFRADL 68 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 D + E + D + + A P +++ + + ++ V+ V + R Sbjct: 69 TDELSFEAPIA---GCDFVFHVA-----TPVHFASEDPENDMIKPAIQGVVNVMKACTRA 120 Query: 122 LIARGVPGAIVNVSSQCSQR 141 + ++ SS + Sbjct: 121 KSVK----RVILTSSAAAVT 136 >4J6F-A nrPDB Length = 382 Score = 38.6 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 27/125 (21%), Positives = 46/125 (36%), Gaps = 2/125 (1%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 AG VLVTGA G+G +Q A GA +AV+ + L + V GD Sbjct: 206 AGETVLVTGASGGVGSAIIQLARARGAVPIAVAGPGKEAAML--DIGAQAVVTRGQGDLA 263 Query: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIAR 125 A P+D++ + L L++ + + + + + L Sbjct: 264 EAVEAASGGRPIDVVADLVGGPLFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQL 323 Query: 126 GVPGA 130 + G+ Sbjct: 324 ELHGS 328 >3OND-A nrPDB Length = 488 Score = 38.6 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 44/102 (43%), Gaps = 14/102 (13%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV-D 60 ++ +AG+ +V G G +G+G AL GARV+ + +L G++ + + D Sbjct: 260 DVMIAGKVAVVAGYGD-VGKGCAAALKQAGARVIVTEIDP--ICALQATMEGLQVLTLED 316 Query: 61 LGDWEATERALGSVGPVDLLV--------NNAAVALLQPFLE 94 + + + G D+++ NNA V + F Sbjct: 317 VVSEADI--FVTTTGNKDIIMLDHMKKMKNNAIVCNIGHFDN 356 >2VN8-A nrPDB Length = 375 Score = 38.2 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 10/111 (9%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 G+RVL+ GA G+G +Q + A A V AV D LVR+ D+ D++ Sbjct: 183 TGKRVLILGASGGVGTFAIQVMKAWDAHVTAVC--SQDASELVRKLG-----ADDVIDYK 235 Query: 66 --ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 + E L S+ P D +++N + + K+ + + V L + Sbjct: 236 SGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKK-WSGATYVTLVTPFLL 285 >1KEU-A nrPDB Length = 361 Score = 38.2 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 62/198 (31%), Gaps = 35/198 (17%) Query: 9 RVLVTGAGKGIGRGTVQALHAT-GARVVAVSRT--QADLDSL--VRECPGIEPVCVDLGD 63 ++L+TG IG V+ + VV + + +L+SL + E D+ D Sbjct: 2 KILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADICD 61 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 R P D +++ AA + + + AF E N+ + ++ + Sbjct: 62 SAEITRIFEQYQP-DAVMHLAAESHVDRSI-TGPAAF---IETNIVGTYALLEVARKYWS 116 Query: 124 ARGVPGAI------VNVSSQCSQRAVTN-------------------HSVYCSTKGALDM 158 A G ++ + S Y ++K + D Sbjct: 117 ALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDH 176 Query: 159 LTKVMALELGPHKIRVNA 176 L + G I N Sbjct: 177 LVRAWRRTYGLPTIVTNC 194 >1R66-A nrPDB Length = 337 Score = 37.8 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 60/166 (36%), Gaps = 29/166 (17%) Query: 9 RVLVTGAGKGIGRGTVQALHATGA-------RVVAVSR-----TQADLDSLVRECPGIEP 56 R+LVTG IG V+ L GA V+ + +A+L + V P + Sbjct: 2 RLLVTGGAGFIGSHFVRQLL-AGAYPDVPADEVIVLDSLTYAGNRANL-APVDADPRLRF 59 Query: 57 VCVDLGDWEATERALGSVGPVDLLVNNAA-------VALLQPFLEVTKEAFDRSFEVNLR 109 V D+ D R + VD +V+ AA +A F E + + + Sbjct: 60 VHGDIRDAGLLAR---ELRGVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVD 116 Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGA 155 A + + V G+I + S + +S Y ++K Sbjct: 117 AGVG----RVVHVSTDEVYGSI-DSGSWTESSPLEPNSPYAASKAG 157 >4G65-A nrPDB Length = 461 Score = 37.4 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 28/75 (37%), Gaps = 4/75 (5%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 RR+++ G G IG + L T V + R + L E C D D E Sbjct: 236 RRIMIVGGGN-IGASLAKRLEQT-YSVKLIERNLQRAEKLSEELENTIVFCGDAADQELL 293 Query: 68 ERALGSVGPVDLLVN 82 ++ VD+ + Sbjct: 294 TE--ENIDQVDVFIA 306 >1OC2-A nrPDB Length = 348 Score = 37.4 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 31/189 (16%), Positives = 59/189 (31%), Gaps = 41/189 (21%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAV-------SRTQADLDSLVRECPGIEPVCVD 60 + ++VTG IG V ++ V + +A+L++++ +E V D Sbjct: 5 KNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNKANLEAIL--GDRVELVVGD 62 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 + D E ++ D +V+ AA + + + N + + + Sbjct: 63 IADAELVDKLAAKA---DAIVHYAAESHN----DNSLNDPSPFIHTNFIGTYTLLEAARK 115 Query: 121 GLIARGVPGAIVNVSSQCSQRA----VTNH-----------------SVYCSTKGALDML 159 I V+ + H S Y STK A D++ Sbjct: 116 YDIRFHH----VSTDEVYGDLPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLI 171 Query: 160 TKVMALELG 168 K G Sbjct: 172 VKAWVRSFG 180 >5INT-A nrPDB Length = 220 Score = 37.4 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 37/104 (35%), Gaps = 24/104 (23%) Query: 5 LAGRRVLVTGA---------------GKG-IGRGTVQALHATGARVVAVSRTQADLDSLV 48 L G+R+L+T G +G + GA V+ VS A Sbjct: 4 LQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTAL----- 58 Query: 49 RECPGIEPVCVDLGDWEAT-ERALGSVGPVDLLVNNAAVALLQP 91 P + V + + E + VD+++ AAVA +P Sbjct: 59 --NPPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRP 100 >6DEB-A nrPDB Length = 285 Score = 37.0 bits (85), Expect = 0.007, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 18/43 (41%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL 44 E+ L G+ ++ GA +GR L GA V DL Sbjct: 155 EIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDL 197 >3VPX-A nrPDB Length = 364 Score = 36.7 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 20/50 (40%), Gaps = 1/50 (2%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG 53 LAG+ V V G G + + LH GA+++ + + V Sbjct: 170 SLAGKTVAVQGVGN-VAYALCEYLHEEGAKLIITDINEEAVQRAVDAFGA 218 >1E3J-A nrPDB Length = 352 Score = 36.7 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 25/74 (33%), Positives = 35/74 (47%), Gaps = 5/74 (6%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G VLV GAG IG +V A A GA VV +R+ L+ + + C + VD E Sbjct: 169 GTTVLVIGAGP-IGLVSVLAAKAYGAFVVCTARSPRRLE-VAKNCGADVTLVVDPAKEEE 226 Query: 67 ---TERALGSVGPV 77 ER ++G + Sbjct: 227 SSIIERIRSAIGDL 240 >3N58-A nrPDB Length = 464 Score = 36.3 bits (83), Expect = 0.012, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ +AG+ +V G G +G+G+ Q+L GARV + +L G E V +D Sbjct: 242 DVMMAGKVAVVCGYGD-VGKGSAQSLAGAGARVKVTEVDP--ICALQAAMDGFEVVTLDD 298 Query: 62 GDWEATERALGSVGPVDLL 80 + + + G D++ Sbjct: 299 A-ASTADIVVTTTGNKDVI 316 >4K28-A nrPDB Length = 269 Score = 36.3 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 33/95 (34%), Gaps = 10/95 (10%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 AG+R LV G G G+G AL G A + + A + ++ P + Sbjct: 124 AGKRALVIGCG-GVGSAIAYALAEAGIASITLCDPSTARMGAVCELLGNGFPGLTVSTQF 182 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEA 99 E LV NA+ + E+ A Sbjct: 183 SGLEDFD--------LVANASPVGMGTRAELPLSA 209 >3PVZ-A nrPDB Length = 399 Score = 36.3 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 32/222 (14%), Positives = 74/222 (33%), Gaps = 23/222 (10%) Query: 9 RVLVTGAGKGIGRGTVQA-LHATGARVVAVSRTQADLDSLVREC--------PGIEPVCV 59 R LV G IG+ + ++ V ++ ++ LVR+ + + Sbjct: 37 RFLVLGGAGSIGQAVTKEIFKRNPQKLHVVDISENNMVELVRDIRSSFGYINGDFQTFAL 96 Query: 60 DLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 D+G E + + + G D ++N +A+ ++ E R +VN+ + Q Sbjct: 97 DIGSIE-YDAFIKADGQYDYVLNLSALKHVRS--EKDPFTLMRMIDVNVFNTDKTIQQSI 153 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNP 179 + + +A ++ ++K ++M + E+ R V Sbjct: 154 DAGAKKYFC--------VSTDKAANPVNMMGASKRIMEMFLMRKSEEIAISTARFANVA- 204 Query: 180 TVVMTSMGQATWSDPHKAKTMLNRIPLGK-FAEVEHVVNAIL 220 S+ K + ++ + + F + L Sbjct: 205 -FSDGSLLHGFNQRIQKNQPIVAPNDIKRYFVTPQESGELCL 245 >4EJ6-A nrPDB Length = 370 Score = 36.3 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 31/84 (36%), Positives = 37/84 (44%), Gaps = 3/84 (3%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD-W 64 AG V + G G IG TVQ GA V +S QA L E V GD Sbjct: 182 AGSTVAILGGGV-IGLLTVQLARLAGATTVILSTRQATKRRLAEEVGATATVDPSAGDVV 240 Query: 65 EATERALGSV-GPVDLLVNNAAVA 87 EA +G V G VD+++ A VA Sbjct: 241 EAIAGPVGLVPGGVDVVIECAGVA 264 >2C54-A nrPDB Length = 379 Score = 35.9 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 34/107 (31%), Gaps = 8/107 (7%) Query: 12 VTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERAL 71 +TGAG I + L G V+A + + + + E VDL E L Sbjct: 34 ITGAGGFIASHIARRLKHEGHYVIASDWKKN--EHMTEDMFCDEFHLVDLRVME---NCL 88 Query: 72 GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 VD + N AA F++ N + + Sbjct: 89 KVTEGVDHVFNLAADMGGMGFIQ---SNHSVIMYNNTMISFNMIEAA 132 >2GAS-A nrPDB Length = 307 Score = 35.9 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 34/85 (40%), Gaps = 11/85 (12%) Query: 9 RVLVTGAGKGIGRGTVQALHATG----ARV--VAVSRTQADLDSLVR--ECPGIEPVCVD 60 ++L+ G IGR V A G A V + + L+ + G+ + D Sbjct: 4 KILILGPTGAIGRHIVWASIKAGNPTYALVRKTITAANPETKEELIDNYQSLGVILLEGD 63 Query: 61 LGDWEATERALGSVGPVDLLVNNAA 85 + D E + ++ VD+++ A Sbjct: 64 INDHE---TLVKAIKQVDIVICAAG 85 >2HK7-A nrPDB Length = 269 Score = 35.5 bits (81), Expect = 0.021, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 46/114 (40%), Gaps = 12/114 (10%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 + +LV GAG G R + AL GA+V +RT+ L ++ P E Sbjct: 124 KSILVLGAG-GASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFP-----------LEVV 171 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 + V ++VN +V L E+ + V + + + ++++ + Sbjct: 172 NSPEEVIDKVQVIVNTTSVGLKDEDPEIFNYDLIKKDHVVVDIIYKETKLLKKA 225 >4WPG-A nrPDB Length = 289 Score = 35.5 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 44/127 (34%), Gaps = 29/127 (22%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 +L+TG+ +G L G VAV + +D+ + + E Sbjct: 7 ILITGSNGQLGTELRYLLDERGVDYVAVDVAE-----------------MDITNEDKVEA 49 Query: 70 ALGSVGPVDLLV-NNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVP 128 V P LV + AA + + +A + + +N+ +++ + Sbjct: 50 VFAQVKP--TLVYHCAAYTAVDAAED-EGKALNEA--INVTGSENIAKACGKY------G 98 Query: 129 GAIVNVS 135 +V +S Sbjct: 99 ATLVYIS 105 >2GGS-A nrPDB Length = 273 Score = 35.1 bits (80), Expect = 0.030, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 43/107 (40%), Gaps = 16/107 (14%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERA 70 L+TGA +G + L V+ V + E G +DL D+ E Sbjct: 4 LITGASGQLGIELSRLLSER-HEVIKVYNSS--------EIQG--GYKLDLTDFPRLEDF 52 Query: 71 LGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117 + D+++N AA + + E ++++++N AV + + Sbjct: 53 IIK-KRPDVIINAAA---MTDVDKCEIEK-EKAYKINAEAVRHIVRA 94 >1LU9-A nrPDB Length = 287 Score = 35.1 bits (80), Expect = 0.030, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 25/85 (29%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 + G++ +V +G + L GA VV R + V V + Sbjct: 116 SVKGKKAVVLAGTGPVGMRSAALLAGEGAEVVLCGRKLDKAQAAADSVNKRFKVNVTAAE 175 Query: 64 WEATERALGSVGPVDLLVNNAAVAL 88 +V + A+ L Sbjct: 176 TADDASRAEAVKGAHFVFTAGAIGL 200 >5ENV-A nrPDB Length = 347 Score = 34.7 bits (79), Expect = 0.032, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 43/99 (43%), Gaps = 9/99 (9%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 +AG V ++GA G+G VQ A G RV+ + + + L R G V +D Sbjct: 167 LMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGIDGGEGK-EELFRSIGGE--VFIDFTK 223 Query: 64 WEATERAL------GSVGPVDLLVNNAAVALLQPFLEVT 96 + A+ G+ G +++ V+ AA+ ++ Sbjct: 224 EKDIVGAVLKATDGGAHGVINVSVSEAAIEASTRYVRAN 262 >1O89-A nrPDB Length = 345 Score = 34.7 bits (79), Expect = 0.036, Method: Composition-based stats. Identities = 16/38 (42%), Positives = 23/38 (60%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 ++VTGA G+G V LH G +VVAVS ++ + L Sbjct: 171 IVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYL 208 >3DFZ-A nrPDB Length = 223 Score = 34.7 bits (79), Expect = 0.041, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 37/104 (35%), Gaps = 15/104 (14%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT--------QADLDSLVRECPGI 54 L L GR VLV G G I ++ GA + V+ T +A V+ Sbjct: 27 LDLKGRSVLVVGGGT-IATRRIKGFLQEGAAITVVAPTVSAEINEWEAKGQLRVKRKKVG 85 Query: 55 EPVCVDL------GDWEATERALGSVGPVDLLVNNAAVALLQPF 92 E +++ + +A + + D LVN A+ Sbjct: 86 EEDLLNVFFIVVATNDQAVNKFVKQHIKNDQLVNMASSFSDGNI 129 >4EJ0-A nrPDB Length = 342 Score = 34.3 bits (78), Expect = 0.042, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 49/155 (31%), Gaps = 21/155 (13%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 ++VTGA IG V+AL+ G + D +D E E Sbjct: 14 TLIVTGAAGFIGANLVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLD--KTEFVE 71 Query: 69 R-ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 R A G G V AV + + + N + S+ V +A+G Sbjct: 72 RFARGDFGKV------RAVFHEGACSDTMETDGRYMMDNN----FRYSRAVLDACLAQGA 121 Query: 128 ------PGAIVNVSS--QCSQRAVTNHSVYCSTKG 154 AI SS + +VY +K Sbjct: 122 QFLYASSAAIYGGSSRFVEEREVEAPLNVYGYSKF 156 >1YB5-A nrPDB Length = 351 Score = 34.3 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 35/76 (46%), Gaps = 1/76 (1%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65 AG VLV GA G+G Q A G +++ + T+ +++ ++ + Sbjct: 170 AGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYID 229 Query: 66 ATERALGSVGPVDLLV 81 ++ +G G +D+++ Sbjct: 230 KIKKYVGEKG-IDIII 244 >1EQ2-A nrPDB Length = 310 Score = 34.0 bits (77), Expect = 0.055, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 50/156 (32%), Gaps = 23/156 (14%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 ++VTG IG V+AL+ G + V D V +D D+ Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQIM 61 Query: 70 ALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPG 129 A G V+ A+ T+ + N Q S+ + + R +P Sbjct: 62 AGEEFGDVE------AIFHEGACSSTTEWDGKYMMDNN----YQYSKELLHYCLEREIP- 110 Query: 130 AIVNVSSQCSQRAVTN-----------HSVYCSTKG 154 + SS + T+ +VY +K Sbjct: 111 -FLYASSAATYGGRTSDFIESREYEKPLNVYGYSKF 145 >4BKP-A nrPDB Length = 336 Score = 34.0 bits (77), Expect = 0.070, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 42/116 (36%), Gaps = 16/116 (13%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 L+ R+LVTG +G+ Q + A GA + + + DL Sbjct: 17 NLYFQSMRILVTGGSGLVGKAI-QKVVADGAGL------------PGEDWVFVSSKDADL 63 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVN---LRAVIQV 114 D T V P ++ A V L ++ + + ++ +N L + +V Sbjct: 64 TDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEV 119 >2BKA-A nrPDB Length = 242 Score = 34.0 bits (77), Expect = 0.071, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 36/103 (34%), Gaps = 11/103 (10%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATG--ARVVAVSRTQADLDSLVRECPGIEPVCV 59 + + + V + GA GR ++ + G ++V + R + D + E V Sbjct: 13 DFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVV-- 70 Query: 60 DLGDWEATERALGSVGPVDLLVNNAAVALLQP----FLEVTKE 98 D+E + + D+ + F+ V ++ Sbjct: 71 ---DFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRD 110 >4N18-A nrPDB Length = 332 Score = 33.6 bits (76), Expect = 0.074, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 21/64 (32%), Gaps = 14/64 (21%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVD 78 IG L G RV SR++ L + + E +G +D Sbjct: 167 IGGYIADQLARLGYRVSGWSRSEKQL--------------AGVTCYRGEEALDHFLGSLD 212 Query: 79 LLVN 82 L+N Sbjct: 213 GLIN 216 >3LK7-A nrPDB Length = 451 Score = 33.6 bits (76), Expect = 0.075, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 34/100 (34%), Gaps = 18/100 (18%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEPVC---- 58 ++VLV G + G + L GA V D + + GI+ VC Sbjct: 7 FENKKVLVLGLARS-GEAAARLLAKLGAIVTVNDGKPFDENPTAQSLLEEGIKVVCGSHP 65 Query: 59 VDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKE 98 ++L D + ++ N + P ++ E Sbjct: 66 LELLDEDFC-----------YMIKNPGIPYNNPMVKKALE 94 >4KUG-A nrPDB Length = 290 Score = 33.6 bits (76), Expect = 0.076, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 1/39 (2%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS 46 ++V V GAG +G G VQA A G V+ + +D Sbjct: 2 KKVFVLGAGT-MGAGIVQAFAAKGCEVIVRDIKEEFVDR 39 >2X86-A nrPDB Length = 357 Score = 33.6 bits (76), Expect = 0.080, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 40/121 (33%), Gaps = 10/121 (8%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R ++VTG IG V+AL+ G + V D V +D D+ Sbjct: 47 RMIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQ 106 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 A G V+ A+ T+ + N Q S+ + + R + Sbjct: 107 IMAGEEFGDVE------AIFHEGACSSTTEWDGKYMMDNN----YQYSKELLHYCLEREI 156 Query: 128 P 128 P Sbjct: 157 P 157 >6GBN-A nrPDB Length = 438 Score = 33.6 bits (76), Expect = 0.080, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 35/84 (41%), Gaps = 14/84 (16%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ +AG+ +V G G +G+G+ +L GARV+ E I + + Sbjct: 214 DVMMAGKVAVVAGYGD-VGKGSAASLRGAGARVIVT------------EIDPICALQAAM 260 Query: 62 GDWEATERALGSVGPVDLLVNNAA 85 D ++ +V D++V Sbjct: 261 -DGYEVKKMADAVKRADIVVTATG 283 >3X2F-A nrPDB Length = 411 Score = 33.6 bits (76), Expect = 0.084, Method: Composition-based stats. Identities = 29/148 (19%), Positives = 52/148 (35%), Gaps = 21/148 (14%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 L +AG+ V+V G G GRG GARV+ + + + P+ + Sbjct: 192 NLLVAGKNVVVAGYGW-CGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVMPMKEAV 250 Query: 62 GDWEATERALGSVGPV---DLL-------VNNAAVA----LLQPFLEVTKEAFDRSFEVN 107 + A G+ + D+L + NA ++ E+ E F+ N Sbjct: 251 KIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEKFEA--RPN 308 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVS 135 + + L G +VN++ Sbjct: 309 VTGYTLENGKTVFLLAE----GRLVNLA 332 >5UOG-A nrPDB Length = 344 Score = 33.6 bits (76), Expect = 0.087, Method: Composition-based stats. Identities = 20/69 (28%), Positives = 28/69 (40%), Gaps = 8/69 (11%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 L L GR V + G G+ IG + L A G + +RT RE G +G Sbjct: 160 LSLRGRTVGLFGLGR-IGLAIARRLEAFGVSIAYHTRTP-------REGLGFTYHPTLVG 211 Query: 63 DWEATERAL 71 EA + + Sbjct: 212 MAEAVDTLI 220 >5JXW-A nrPDB Length = 498 Score = 33.6 bits (76), Expect = 0.089, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 44/101 (43%), Gaps = 16/101 (15%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL-- 61 LAG++++V G G+ +G+G Q L GARV+ ++D + +E V + Sbjct: 268 MLAGKKIVVLGYGE-VGKGCAQGLSGVGARVIVT-----EIDPICALQASMEGYQVSVLE 321 Query: 62 GDWEATERALGSVGPVDLLV--------NNAAVALLQPFLE 94 + + + G D++ NA +A + F + Sbjct: 322 DVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDD 362 >6C55-A nrPDB Length = 340 Score = 33.2 bits (75), Expect = 0.10, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 22/63 (34%), Gaps = 1/63 (1%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+++ V G G G Q L G VV R D + + PV + Sbjct: 15 LQGKKIAVVGYGS-QGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQA 73 Query: 65 EAT 67 + Sbjct: 74 DVI 76 >6APH-A nrPDB Length = 445 Score = 33.2 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 31/74 (41%), Gaps = 1/74 (1%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ LAG+RV+V G G +G+GT + G+ V E ++ + + Sbjct: 221 DVMLAGKRVVVCGFGD-VGKGTAASFRGAGSIVTVTEIDPICALQAAMEGYEVKQLDTVV 279 Query: 62 GDWEATERALGSVG 75 + + G+ G Sbjct: 280 DNADIIITTTGNFG 293 >6APE-A nrPDB Length = 298 Score = 33.2 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 39/104 (37%), Gaps = 6/104 (5%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + + G+ V + GA IG+ + GA V D+ + + VCV +G Sbjct: 166 IEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQ---NADIVCVGVG 222 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV 106 + + ++ G V V + + L V F + +V Sbjct: 223 KPDLIKASMLKKGAV---VVDIGINHLNDGRIVGDVDFTNAQKV 263 >3DMF-A nrPDB Length = 381 Score = 33.2 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 38/98 (38%), Gaps = 7/98 (7%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL-GDWE 65 GR+VL GAG G L GA VV V + DL S++ G+E + Sbjct: 234 GRQVLDLGAGYG---ALTLPLARMGAEVVGV---EDDLASVLSLQKGLEANALKAQALHS 287 Query: 66 ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRS 103 + AL D++V N + + +AF Sbjct: 288 DVDEALTEEARFDIIVTNPPFHVGGAVILDVAQAFVNV 325 >6G2J-P nrPDB Length = 377 Score = 33.2 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 22/126 (17%), Positives = 45/126 (35%), Gaps = 18/126 (14%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQA---DLDSLVRECPGIEPVCVD 60 ++G V GA +GR V L G++V+ R L+ + + + D Sbjct: 50 SVSGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLGQLTFLEWD 109 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 D ++ +A+ +N + L+ E F+ F + + + +A+ Sbjct: 110 ARDKDSIRKAVQH--------SNVVINLIGREWETRNFDFEDVF-------VNIPRAIAQ 154 Query: 121 GLIARG 126 G Sbjct: 155 ASKEAG 160 >3WMX-A nrPDB Length = 358 Score = 32.8 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 68/190 (35%), Gaps = 30/190 (15%) Query: 6 AGR-RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC--VDLG 62 AG+ ++L+ GA IG AL RT +V + ++ Sbjct: 23 AGKPKILIVGANGQIGSELALALAER------YGRTNVITSDVVPTGRHVHLTHEMLNAT 76 Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR-G 121 D + G + + AA++ ++A ++ +N+ +++ V ++ + G Sbjct: 77 DRGELATVVERHGITQVYLLAAALSATG------EKAPQWAWNLNMTSLLNVLELARQTG 130 Query: 122 LIARGVPGAIVNV--SSQCSQRAVTN----HSVYCSTKGALDMLTKVMALEL--GPHKIR 173 L P +I ++ Q +VY +K A + + H + Sbjct: 131 LERVFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCR-----WYHANHGVD 185 Query: 174 VNAVN-PTVV 182 V +V P ++ Sbjct: 186 VRSVRYPGLI 195 >4EUF-A nrPDB Length = 418 Score = 32.8 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 17/107 (15%), Positives = 32/107 (29%), Gaps = 22/107 (20%) Query: 8 RRVLVTGAGKGIGRG--TVQALHATGARVVAVSRTQADLDSLV-----------RECPGI 54 ++VL+ GA G G A A + VS D + +E Sbjct: 61 KKVLIVGASSGFGLATRISVAFGGPEAHTIGVSYETGATDRRIGTAGWYNNIFFKEFAKK 120 Query: 55 EPVCV---------DLGDWEATERALGSVGPVDLLVNNAAVALLQPF 92 + + + + + G +DL V + A + + Sbjct: 121 KGLVAKNFIEDAFSNETKDKVIKYIKDEFGKIDLFVYSLAAPRRKDY 167 >2QYS-A nrPDB Length = 318 Score = 32.8 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 34/80 (42%), Gaps = 1/80 (1%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 ++L+ G IG V+ G +R + +L+ E + + V G+ + E Sbjct: 13 KILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGAIIVK-GELDEHE 71 Query: 69 RALGSVGPVDLLVNNAAVAL 88 + + + VD++++ A Sbjct: 72 KLVELMKKVDVVISALAFPQ 91 >4J90-A nrPDB Length = 222 Score = 32.4 bits (73), Expect = 0.16, Method: Composition-based stats. Identities = 11/64 (17%), Positives = 23/64 (35%), Gaps = 3/64 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 + ++ V G G+ G + LH G V+AV + +++ V + + Sbjct: 3 RIKNKQFAVIGLGR-FGGSICKELHRMGHEVLAVDINEEKVNAYAS--YATHAVIANATE 59 Query: 64 WEAT 67 Sbjct: 60 ENEL 63 >6C6P-A nrPDB Length = 458 Score = 32.4 bits (73), Expect = 0.17, Method: Composition-based stats. Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 3/67 (4%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEPVCVDLGDWEAT 67 V++ GAG +G L G +V + R + D +V E PG V DLG + Sbjct: 10 VIIVGAGV-LGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTV 68 Query: 68 ERALGSV 74 E V Sbjct: 69 EGLDAQV 75 >7REQ-A nrPDB Length = 727 Score = 32.4 bits (73), Expect = 0.17, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 26/85 (30%), Gaps = 9/85 (10%) Query: 23 TVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE--------ATERALGSV 74 A G V Q + R+ + V + A + L + Sbjct: 616 IATAYADLGFDVDVGPLFQ-TPEETARQAVEADVHVVGVSSLAGGHLTLVPALRKELDKL 674 Query: 75 GPVDLLVNNAAVALLQPFLEVTKEA 99 G D+L+ V Q F E+ K+ Sbjct: 675 GRPDILITVGGVIPEQDFDELRKDG 699 >3MOG-A nrPDB Length = 483 Score = 32.4 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 38/240 (15%), Positives = 79/240 (32%), Gaps = 42/240 (17%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 + L + V V G+G +G G + + G +V+ + L + V G Sbjct: 1 MSLNVQTVAVIGSGT-MGAGIAEVAASHGHQVLLYDISAEALTRAIDGIHARLNSRVTRG 59 Query: 63 D--WEATERALGSVGPV-DLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVA 119 E ER L + PV D+ A+A +E E + +A+ V Sbjct: 60 KLTAETCERTLKRLIPVTDI----HALAAADLVIEAASERLEVK-----KALFAQLAEVC 110 Query: 120 RGLIARGVPGAIVNVSSQCSQRAVTNH-----------------SVYCSTKGA--LDMLT 160 + +++++ ++ V A ++ L Sbjct: 111 PPQTLLTTNTSSISITAIAAEIKNPERVAGLHFFNPAPVMKLVEVVSGLATAAEVVEQLC 170 Query: 161 KVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAIL 220 + + L G +R ++ P ++ + + +S+ +A P V++A L Sbjct: 171 E-LTLSWGKQPVRCHS-TPGFIVNRVARPYYSEAWRALEEQVAAP--------EVIDAAL 220 >4WOK-A nrPDB Length = 336 Score = 32.0 bits (72), Expect = 0.21, Method: Composition-based stats. Identities = 22/85 (25%), Positives = 30/85 (35%), Gaps = 4/85 (4%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 VLV G IG T + L G V S VR V D+ D Sbjct: 14 VLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRWGD---FVEGDILDQARLVE 70 Query: 70 ALGSVGPVDLLVNNAAVALLQPFLE 94 + PV +++ AA A + +E Sbjct: 71 TMEKYAPV-AVIHFAASAYVGESVE 94 >6ACQ-A nrPDB Length = 302 Score = 32.0 bits (72), Expect = 0.24, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 18/39 (46%), Gaps = 1/39 (2%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS 46 ++V V GAG +G G QA A G VV +D Sbjct: 22 KKVCVIGAGT-MGSGIAQAFAAKGFEVVLRDIKDEFVDR 59 >5YBH-A nrPDB Length = 368 Score = 32.0 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 44/128 (34%), Gaps = 15/128 (11%) Query: 19 IGRGTVQALHATGARVVAV-------SRTQADLDSLVRECPGIEPVCVDLGDWEATERAL 71 I + G +V +R D+ E P V + +++ R L Sbjct: 167 IATAIAEFFRTEGHKVALFIDSLTRYARALRDVALAAGESPARRGYPVSV--FDSLPRLL 224 Query: 72 GSVGPVDLLVNNAAVALLQPF-LEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGA 130 G + A ++ + + + + F +R+++ ++R L +G A Sbjct: 225 ERPGKL-----KAGGSITAFYTVLLEDDDFADPLAEEVRSILDGHIYLSRNLAQKGQFPA 279 Query: 131 IVNVSSQC 138 I ++ S Sbjct: 280 IDSLKSIS 287 >4B4V-A nrPDB Length = 303 Score = 31.6 bits (71), Expect = 0.28, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 27/68 (39%), Gaps = 3/68 (4%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 + +AG+ +V G +G+ L A V +L LV++ + + + Sbjct: 174 NIEIAGKHAVVVGRSAILGKPMAMMLLQANATVTICHSRTQNLPELVKQ---ADIIVGAV 230 Query: 62 GDWEATER 69 G E ++ Sbjct: 231 GKAELIQK 238 >1DB3-A nrPDB Length = 372 Score = 31.6 bits (71), Expect = 0.30, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 58/186 (31%), Gaps = 36/186 (19%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ-----ADLDSLVRE----CPGIEPVC 58 + L+TG G + L G V + R +D + ++ P Sbjct: 2 KVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHY 61 Query: 59 VDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 DL D R L V P D + N A++ + V+ E+ + + +V+ +++ + + Sbjct: 62 GDLSDTSNLTRILREVQP-DEVYNLGAMSH----VAVSFESPEYTADVDAMGTLRLLEAI 116 Query: 119 ARGLIARGVPGAIVNVSSQCSQ---------RAVTNHSVYCSTKGALDMLTKVMALELGP 169 + + + S S Y K L Sbjct: 117 RFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAK-------------LYA 163 Query: 170 HKIRVN 175 + I VN Sbjct: 164 YWITVN 169 >2EER-A nrPDB Length = 347 Score = 31.6 bits (71), Expect = 0.30, Method: Composition-based stats. Identities = 12/46 (26%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 8 RRVLVTGAGKGIGR-GTVQALHATGARVVAVSRTQADLDSLVRECP 52 + ++V GAG G+G A +GA ++ V + L++ R Sbjct: 172 KTLVVIGAGGGLGTMAIQIAKAVSGATIIGVDVREEALEAAKRAGA 217 >5BUT-A nrPDB Length = 288 Score = 31.6 bits (71), Expect = 0.31, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 24/64 (37%), Gaps = 3/64 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 + ++ V G G+ G V+ LH G V+AV + +++ V + + Sbjct: 3 RIKNKQFAVIGLGR-FGGSIVKELHRMGHEVLAVDINEEKVNAYAS--YATHAVIANATE 59 Query: 64 WEAT 67 Sbjct: 60 ENEL 63 Score = 31.6 bits (71), Expect = 0.31, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 25/64 (39%), Gaps = 4/64 (6%) Query: 5 LAG-RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G ++ V G G+ G V+ LH G V+AV + +++ V + + Sbjct: 145 LEGSKQFAVIGLGR-FGGSIVKELHRMGHEVLAVDINEEKVNAYAS--YATHAVIANATE 201 Query: 64 WEAT 67 Sbjct: 202 ENEL 205 >2VWV-A nrPDB Length = 302 Score = 31.6 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 33/90 (36%), Gaps = 21/90 (23%) Query: 155 ALDMLTKVMA------LELGPHKIRVNA-----VNPTVVMTSMGQATWSDPHKAKTMLNR 203 + + +A +L I VN+ V+ ++ + SDP + ++ + Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVS-DFGLSRFLEENSSDPTETSSLGGK 184 Query: 204 IPLGKFAEVEHVVNAILFL----LSDRSGM 229 IP+ ++ E AI F SD Sbjct: 185 IPI-RWTAPE----AIAFRKFTSASDAWSY 209 >2HMT-A nrPDB Length = 144 Score = 31.6 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 24/64 (37%), Gaps = 3/64 (4%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 + ++ V G G+ G V+ LH G V+AV + +++ V + + Sbjct: 3 RIKNKQFAVIGLGR-FGGSIVKELHRMGHEVLAVDINEEKVNAYAS--YATHAVIANATE 59 Query: 64 WEAT 67 Sbjct: 60 ENEL 63 >3HDH-A nrPDB Length = 302 Score = 31.6 bits (71), Expect = 0.34, Method: Composition-based stats. Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 7/66 (10%) Query: 8 RRVLV---TGAGKGI-GRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 +++LV T G G+ G G Q ATG VV V +T+ D L + GIE + Sbjct: 11 KKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE---DILAKSKKGIEESLRKVAK 67 Query: 64 WEATER 69 + E Sbjct: 68 KKFAEN 73 >3F6S-A nrPDB Length = 148 Score = 31.6 bits (71), Expect = 0.35, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 24/79 (30%), Gaps = 9/79 (11%) Query: 8 RRVLVTGAGKGIGRGTVQAL----HATGARVVAVSRTQADLDSLVRECPGIEPVCV---- 59 + ++V G+ G Q L A G V ++ A ++L + C Sbjct: 3 KVLIVFGSSTGNTESIAQKLEELIAAGGHEVTLLNAADASAENLADGYDAVLFGCSAWGM 62 Query: 60 -DLGDWEATERALGSVGPV 77 DL + + Sbjct: 63 EDLEMQDDFLSLFEEFDRI 81 >3PEF-A nrPDB Length = 287 Score = 31.3 bits (70), Expect = 0.36, Method: Composition-based stats. Identities = 6/43 (13%), Positives = 13/43 (30%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 +G + L G V +R+ + L ++ Sbjct: 12 MGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEV 54 >3IP1-A nrPDB Length = 404 Score = 31.3 bits (70), Expect = 0.37, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 23/66 (34%), Gaps = 3/66 (4%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G V++ G G IG V L GA V +S +L +E +D Sbjct: 214 GDNVVILGGGP-IGLAAVAILKHAGASKVILSEPSEVRRNLAKELGADH--VIDPTKENF 270 Query: 67 TERALG 72 E L Sbjct: 271 VEAVLD 276 >2Q4B-A nrPDB Length = 253 Score = 31.3 bits (70), Expect = 0.38, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 23/73 (31%), Gaps = 4/73 (5%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 VLVTGA G+ V G+ + + D+ D ++ Sbjct: 6 TVLVTGASGRTGQ-IVYKKLKEGSDKFVAKGLVRSAQGKEKIGGEADVFIGDITDADSIN 64 Query: 69 RALGSVGPVDLLV 81 A +D LV Sbjct: 65 PAFQ---GIDALV 74 >1RPN-A nrPDB Length = 335 Score = 31.3 bits (70), Expect = 0.38, Method: Composition-based stats. Identities = 19/69 (27%), Positives = 27/69 (39%), Gaps = 6/69 (8%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARV--VAVSRTQA---DLDSLVRECPGIEPVCVDLG 62 R LVTG G + L G RV + R+ L L E I+ D+ Sbjct: 15 RSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGD-IQYEDGDMA 73 Query: 63 DWEATERAL 71 D + +RA+ Sbjct: 74 DACSVQRAV 82 >3H9U-A nrPDB Length = 436 Score = 31.3 bits (70), Expect = 0.38, Method: Composition-based stats. Identities = 31/150 (20%), Positives = 54/150 (36%), Gaps = 15/150 (10%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ +AG+ V G G +G+G AL GARVV + E + V + Sbjct: 206 DVMIAGKTACVCGYGD-VGKGCAAALRGFGARVVVTEVDPINALQAAMEGYQVLLVEDVV 264 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV-----NLRAVIQVSQ 116 E + + G D++ + + + FD +V N + ++V Sbjct: 265 ---EEAHIFVTTTGNDDIITSEHFPRMRDDAIVCNIGHFDTEIQVAWLKANAKERVEVKP 321 Query: 117 IVARGLIARGVP------GAIVNVSSQCSQ 140 V R +A G G +VN+ Sbjct: 322 QVDRYTMANGRHIILLAEGRLVNLGCASGH 351 >1F14-A nrPDB Length = 310 Score = 31.3 bits (70), Expect = 0.41, Method: Composition-based stats. Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 6/66 (9%) Query: 7 GRRVL--VTGAGKGI-GRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 + ++ VT G G+ G G Q ATG VV V +T+ D L + GIE + Sbjct: 11 KKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE---DILAKSKKGIEESLRKVAK 67 Query: 64 WEATER 69 + E Sbjct: 68 KKFAEN 73 >6CU3-A nrPDB Length = 336 Score = 31.3 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 29/83 (34%), Gaps = 6/83 (7%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGAR-VVAVSRTQ--ADLDSLVRECPGIEPVC 58 + + VL G G GI GA+ V+ + + +V + + Sbjct: 47 KHLFKDKVVLDIGCGTGI---LCLFAAKAGAKRVIGIDMSDIIDKARQIVSDNGYSHVIE 103 Query: 59 VDLGDWEATERALGSVGPVDLLV 81 + G E + + VD+++ Sbjct: 104 LIKGKVEDIAQLPFGIEKVDIII 126 >1XDW-A nrPDB Length = 331 Score = 31.3 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 23/58 (39%), Gaps = 10/58 (17%) Query: 12 VTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 V G G+ IGR Q H GA V+ V E GIE C + E E+ Sbjct: 151 VVGLGR-IGRVAAQIFHGMGATVIGED---------VFEIKGIEDYCTQVSLDEVLEK 198 >4B4O-A nrPDB Length = 298 Score = 31.3 bits (70), Expect = 0.46, Method: Composition-based stats. Identities = 27/113 (23%), Positives = 37/113 (32%), Gaps = 18/113 (15%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 RVLV G IG Q L+A G V VSR PG + D E Sbjct: 2 RVLVGGGTGFIGTALTQLLNARGHEVTLVSRK-----------PGPGRITWD-------E 43 Query: 69 RALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 A + D VN A +L P + L +++ + + Sbjct: 44 LAASGLPSCDAAVNLAGENILNPLRRWNETFQKEVLGSRLETTQLLAKAITKA 96 >5M65-A nrPDB Length = 479 Score = 30.9 bits (69), Expect = 0.50, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 57/165 (34%), Gaps = 27/165 (16%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCV-D 60 ++ L+G+ +V G G +G+G+ +L G RV+ + +L G E V + D Sbjct: 255 DVMLSGKVAMVAGFGD-VGKGSAASLRQAGCRVMVSEVDP--ICALQAAMEGYEVVTMED 311 Query: 61 LGDWEATERALGSVGPVDL-------------LVNNAAVALLQPFLEVTKEAFDRSFEVN 107 + + G D+ +V N E+ + N Sbjct: 312 AAPRADI--FVTATGNKDIITIEHMRAMKDRAIVCNIGHFDN----EIQIASLRNLKWTN 365 Query: 108 LRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCST 152 ++ + + + I G +VN+ + + V ++ Sbjct: 366 IKPQVDEIEFPDKHRIIMLSEGRLVNLGNAMGHPSF----VMSAS 406 >4D3S-A nrPDB Length = 293 Score = 30.9 bits (69), Expect = 0.52, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 16/36 (44%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI 54 +G+ AL G + +RT+A ++L + Sbjct: 19 MGQAMAGALLEAGYELTVWNRTKAKAEALAERGAAV 54 >2OWO-A nrPDB Length = 671 Score = 30.9 bits (69), Expect = 0.53, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 33/74 (44%), Gaps = 5/74 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQ-ALHATGARVVAVSRTQADL----DSLVRECPGIEPVCV 59 AG+ V++TG+ + R + L GA+V + DL ++ + + + + Sbjct: 598 FAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGI 657 Query: 60 DLGDWEATERALGS 73 ++ D R LGS Sbjct: 658 EVIDEAEMLRLLGS 671 >4G2N-A nrPDB Length = 345 Score = 30.9 bits (69), Expect = 0.56, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 21/52 (40%), Gaps = 3/52 (5%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP 52 + + L GRR+ + G G+ IGR A G + + L + E Sbjct: 167 LGMGLTGRRLGIFGMGR-IGRAIATR--ARGFGLAIHYHNRTRLSHALEEGA 215 >5GXF-A nrPDB Length = 330 Score = 30.5 bits (68), Expect = 0.63, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 17/38 (44%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 VLVTGA G+G L G V AV+ D L Sbjct: 153 VLVTGAAGGVGSVATAILAHLGYEVAAVTGRPETADYL 190 >4A5O-A nrPDB Length = 286 Score = 30.5 bits (68), Expect = 0.64, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 16/48 (33%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECP 52 L G +V GA +GR L G V R DL V Sbjct: 159 LYGMDAVVVGASNIVGRPMALELLLGGCTVTVTHRFTRDLADHVSRAD 206 >4DGK-A nrPDB Length = 501 Score = 30.5 bits (68), Expect = 0.65, Method: Composition-based stats. Identities = 18/68 (26%), Positives = 24/68 (35%), Gaps = 4/68 (5%) Query: 12 VTGAGKGIGRGTVQALHATGARVVAVS-RTQADLDSLVRECPG--IEPVCVDLGDWEATE 68 V GAG G G L A G V+ + R + + V E G + + D A E Sbjct: 6 VIGAGFG-GLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQGFTFDAGPTVITDPSAIE 64 Query: 69 RALGSVGP 76 G Sbjct: 65 ELFALAGK 72 >3BIC-A nrPDB Length = 762 Score = 30.5 bits (68), Expect = 0.67, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 33/107 (30%), Gaps = 18/107 (16%) Query: 14 GAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERAL-- 71 G +G + G V Q + ++ + V + A + L Sbjct: 616 GHDRG-AKVIATGFADLGFDVDIGPLFQ-TPREVAQQAVDADVHAVGVSTLAAGHKTLVP 673 Query: 72 ------GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112 S+G D+LV V + + ++ FEV + V Sbjct: 674 ELIKELNSLGRPDILVMCGGV--------IPPQDYEFLFEVGVSNVF 712 >2ZJ1-A nrPDB Length = 495 Score = 30.5 bits (68), Expect = 0.67, Method: Composition-based stats. Identities = 18/74 (24%), Positives = 34/74 (45%), Gaps = 4/74 (5%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G++VL+ G G +G+G +A+ GARV + + E + V +GD + Sbjct: 275 GKKVLICGYGD-VGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADI 333 Query: 67 TERALGSVGPVDLL 80 + + G D++ Sbjct: 334 V---VTATGNKDII 344 >6F3O-A nrPDB Length = 472 Score = 30.5 bits (68), Expect = 0.68, Method: Composition-based stats. Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 10/85 (11%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVC--- 58 + L+G++ LV G G +G+G+ Q+L G V + ++ G E V Sbjct: 219 DHLLSGKQALVIGYGD-VGKGSSQSLRQEGMIVKVAEVDP--ICAMQACMDGFEVVSPYK 275 Query: 59 --VDLGDWEATERALGSVGPVDLLV 81 ++ G + + AL +G +DL+V Sbjct: 276 NGINDGTEASIDAAL--LGKIDLIV 298 >6BI4-A nrPDB Length = 346 Score = 30.5 bits (68), Expect = 0.68, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 59/158 (37%), Gaps = 18/158 (11%) Query: 10 VLVTGAGKGIGRGTVQALHA--TGARVV----AVSRTQADLDSLVRECPGIEPVCVDLGD 63 +LVTG IG V + +++ + +++ P V ++ + Sbjct: 27 ILVTGGAGFIGSNFVHYMLQSYETYKIINFDALTYSGNLNNVKSIQDHPNYYFVKGEIQN 86 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG-- 121 E E + V ++VN AA + ++ + E ++ N+ + + ++V + Sbjct: 87 GELLEHVIKE-RDVQVIVNFAA----ESHVDRSIENPIPFYDTNVIGTVTLLELVKKYPH 141 Query: 122 -----LIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKG 154 + V G++ + + +S Y S+K Sbjct: 142 IKLVQVSTDEVYGSLGKTGRFTEETPLAPNSPYSSSKA 179 >5YWN-A nrPDB Length = 334 Score = 30.5 bits (68), Expect = 0.69, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 50/133 (37%), Gaps = 10/133 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG--IEPVCVDLGDWEAT 67 V V+GA + + + + + G +VV R++ +L + V L A Sbjct: 5 VFVSGATGYLAQQIIALVLSKGYKVVGSVRSEEKGANLKKLYGDDFSYEVVKVLEQKGAF 64 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGV 127 + AL V + ++ A+ + + KE + + V+Q + VA + Sbjct: 65 DEALKKHPEVTIFLHTAS-PVTFEVEDTEKEILIPAING-TKYVLQSIKDVAPQIT---- 118 Query: 128 PGAIVNVSSQCSQ 140 +V SS + Sbjct: 119 --RVVYTSSVVAM 129 >1QYD-A nrPDB Length = 313 Score = 30.5 bits (68), Expect = 0.73, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 43/98 (43%), Gaps = 11/98 (11%) Query: 5 LAGR-RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ--ADLDSLV----RECPGIEPV 57 + + RVL+ G IG+ V A + G + R + +++D + + G + + Sbjct: 1 MDKKSRVLIVGGTGYIGKRIVNASISLGHPTYVLFRPEVVSNIDKVQMLLYFKQLGAKLI 60 Query: 58 CVDLGDWEATERALGSVGPVDLLVNN-AAVALLQPFLE 94 L D +R + ++ VD++++ A L LE Sbjct: 61 EASLDDH---QRLVDALKQVDVVISALAGGVLSHHILE 95 >1C0L-A nrPDB Length = 363 Score = 30.5 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 20/41 (48%), Gaps = 1/41 (2%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD 43 + + +RV+V G+G IG + L G V ++R + Sbjct: 2 MMHSQKRVVVLGSGV-IGLSSALILARKGYSVHILARDLPE 41 >4OMU-A nrPDB Length = 283 Score = 30.1 bits (67), Expect = 0.80, Method: Composition-based stats. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 10/94 (10%) Query: 5 LAGRRVLVTGAGKGIGRGTVQ-ALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 LAG+R+L+ GAG + RG ++ L +V +RT + L RE + PV Sbjct: 117 LAGKRILILGAGGAV-RGVLEPILAHKPQSLVIANRTVEKAEQLAREFDELGPVVASGFA 175 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTK 97 W PVD+++N + +L + Sbjct: 176 WLQ--------EPVDVIINATSASLAGELPPIAD 201 >1JAY-A nrPDB Length = 212 Score = 30.1 bits (67), Expect = 0.84, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 14/32 (43%), Gaps = 1/32 (3%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSR 39 R L+ G +G+G L G +V SR Sbjct: 2 RVALL-GGTGNLGKGLALRLATLGHEIVVGSR 32 >1EEP-A nrPDB Length = 404 Score = 30.1 bits (67), Expect = 0.84, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 42/112 (37%), Gaps = 11/112 (9%) Query: 45 DSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSF 104 L + V +D+ E E + + VD+LV ++A +E+ K+ + Sbjct: 136 KDLNNKLRVGAAVSIDIDTIERVEELVKA--HVDILVIDSAHGHSTRIIELIKKIKTKYP 193 Query: 105 EVNLRAVIQVSQIVARGLIARGV--------PGAIVNVSSQCSQRAVTNHSV 148 ++L A V++ A LI+ G PG+I V + Sbjct: 194 NLDLIAGNIVTKEAALDLISVGADCLKVGIGPGSICTTRIVAGV-GVPQITA 244 >4FQ8-A nrPDB Length = 271 Score = 30.1 bits (67), Expect = 0.90, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 20/46 (43%), Gaps = 4/46 (8%) Query: 3 LFLAGRR---VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD 45 L L + L+ GAG G + L G +V ++R+ LD Sbjct: 111 LSLKQKNYQNALILGAG-GSAKALACELKKQGLQVSVLNRSSRGLD 155 >1ZCJ-A nrPDB Length = 463 Score = 30.1 bits (67), Expect = 0.92, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 14/31 (45%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVR 49 +GRG + G VVAV LD+ + Sbjct: 48 MGRGIAISFARVGISVVAVESDPKQLDAAKK 78 >2DFV-A nrPDB Length = 347 Score = 30.1 bits (67), Expect = 0.93, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 30/79 (37%), Gaps = 15/79 (18%) Query: 6 AGRRVLVTGAG--KGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPV------ 57 +G+ VL+TGAG +G +A +GA V VS L ++ + Sbjct: 166 SGKSVLITGAGPLGLLGIAVAKA---SGAYPVIVSEPSDFRRELAKKVGADYVINPFEED 222 Query: 58 ----CVDLGDWEATERALG 72 +D+ D + L Sbjct: 223 VVKEVMDITDGNGVDVFLE 241 >6BII-A nrPDB Length = 333 Score = 30.1 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 23/51 (45%), Gaps = 3/51 (5%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQ--ADLDSLVRECPGIE 55 G+ + + G G+ IG+ + G R++ +R++ L E +E Sbjct: 150 GKTIGIVGFGR-IGQAIAKRAKGFGMRILYTARSRKPEAEKELGAEFKPLE 199 >5KIA-A nrPDB Length = 351 Score = 30.1 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 26/82 (31%), Gaps = 7/82 (8%) Query: 1 MELFLAGRRVLVTGAGKGIG---RGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPV 57 + L G VL+TGAG IG + + A VV LD L R V Sbjct: 166 LSFNLVGEDVLITGAGP-IGVMAVAIAKHVGAR--NVVITDINDYRLD-LARRMGATRAV 221 Query: 58 CVDLGDWEATERALGSVGPVDL 79 V L D+ Sbjct: 222 NVSRESLRDVMADLHMTEGFDV 243 >1X74-A nrPDB Length = 360 Score = 29.7 bits (66), Expect = 1.0, Method: Composition-based stats. Identities = 20/67 (29%), Positives = 26/67 (38%), Gaps = 3/67 (4%) Query: 18 GIGRG--TVQALHATGARVVAVSRTQA-DLDSLVRECPGIEPVCVDLGDWEATERALGSV 74 GIG G L GA VV + R + D S V DL + E AL + Sbjct: 15 GIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELALKLI 74 Query: 75 GPVDLLV 81 D+L+ Sbjct: 75 AKADVLI 81 >4AZW-A nrPDB Length = 471 Score = 29.7 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 34/103 (33%), Gaps = 17/103 (16%) Query: 14 GAGKGIGRGTVQALHATGARVVAVSRTQADL---DSLVRECPGIEPVCVDLGDWEATERA 70 G +G +L + GA +V + Q ++ +L E P +G E A Sbjct: 74 GCAQGF---FSLSLASKGATIVGIDFQQENINVCRALAEENPDF-AAEFRVGRIEEVIAA 129 Query: 71 LGSVGPVDL---------LVNNAAVALLQPFLEVTKEAFDRSF 104 L G DL +V+ + ++ L + Sbjct: 130 LEE-GEFDLAIGLSVFHHIVHLHGIDEVKRLLSRLADVTQAVI 171 >4AZV-A nrPDB Length = 569 Score = 29.7 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 34/103 (33%), Gaps = 17/103 (16%) Query: 14 GAGKGIGRGTVQALHATGARVVAVSRTQADL---DSLVRECPGIEPVCVDLGDWEATERA 70 G +G +L + GA +V + Q ++ +L E P +G E A Sbjct: 74 GCAQGF---FSLSLASKGATIVGIDFQQENINVCRALAEENPDF-AAEFRVGRIEEVIAA 129 Query: 71 LGSVGPVDL---------LVNNAAVALLQPFLEVTKEAFDRSF 104 L G DL +V+ + ++ L + Sbjct: 130 LEE-GEFDLAIGLSVFHHIVHLHGIDEVKRLLSRLADVTQAVI 171 >5UZH-A nrPDB Length = 345 Score = 29.7 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 18/99 (18%), Positives = 37/99 (37%), Gaps = 10/99 (10%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQA-----DLDSLVREC----PGIEPVC 58 + L+TG G + L G V + R + ++ L ++ + + Sbjct: 2 KVALITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLLY 61 Query: 59 VDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTK 97 DL D + + P D + N AA + ++ E+ + Sbjct: 62 GDLTDTGNLISIIAKIKP-DEIYNLAAQSHVKVSFEMPE 99 >2ZSK-A nrPDB Length = 226 Score = 29.7 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 47/131 (35%), Gaps = 27/131 (20%) Query: 24 VQALHATGARVVAVSRTQADL--DSLVRECPGIEPVCVDLGDWEATERALGSV------- 74 +AL GA ++A + L D + RE +D E +R + V Sbjct: 66 AKALERAGAELIAFAANTPHLVFDDVQREVNVPMVSIIDAVAEEILKRGVRKVLLLGTKT 125 Query: 75 -------------GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 ++++V N + E+ + F+ NL+ + +++ + Sbjct: 126 TMTADFYIKTLEEKGLEVVVPN-----DEEKEELNRIIFEELAFGNLKNKEWIVRLIEKY 180 Query: 122 LIARGVPGAIV 132 + G+ G I+ Sbjct: 181 RESEGIEGVIL 191 >5U9C-A nrPDB Length = 292 Score = 29.7 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 26/76 (34%), Gaps = 7/76 (9%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRT-------QADLDSLVRECPGIEPVCV 59 R++L+TG +G AL T V+ R +A + E P + Sbjct: 5 KRKILITGGTGMLGAYVTSALKDTDYNVIVTERNTLNLSVPEAIFSYITAEKPDVILHFA 64 Query: 60 DLGDWEATERALGSVG 75 D + ER G Sbjct: 65 AETDVDLCEREPARAG 80 >2R5U-A nrPDB Length = 200 Score = 29.7 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 9/52 (17%), Positives = 18/52 (34%) Query: 21 RGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALG 72 + ++ L G RVV A+ + + D+ D +E + Sbjct: 129 KALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQAEIYDVADRRLSEDFVA 180 >4WKG-A nrPDB Length = 660 Score = 29.7 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 37/113 (32%), Gaps = 4/113 (3%) Query: 9 RVLVTGAGKGIGRGTVQALHAT-GARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 RVL+ G IG + L V + + + P V D+ Sbjct: 317 RVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFL-NHPHFHFVEGDISIHS-- 373 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 E V D+++ A+A + F+ FE NLR + + R Sbjct: 374 EWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKR 426 >3ZWA-A nrPDB Length = 742 Score = 29.7 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 14/31 (45%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVR 49 +GRG + G VVAV LD+ + Sbjct: 327 MGRGIAISFARVGISVVAVESDPKQLDAAKK 357 >2RIR-A nrPDB Length = 300 Score = 29.7 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 25/68 (36%), Gaps = 13/68 (19%) Query: 18 GIGRG---TVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSV 74 G+GR + A GA V +R+ A L + G+ P D V Sbjct: 164 GLGRTGMTIARTFAALGANVKVGARSSAHLARITE--MGLVPFHTD--------ELKEHV 213 Query: 75 GPVDLLVN 82 +D+ +N Sbjct: 214 KDIDICIN 221 >2D0I-A nrPDB Length = 333 Score = 29.3 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 18/39 (46%), Gaps = 1/39 (2%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQA 42 L G++V + G IG+ + L G ++ SR + Sbjct: 143 SLYGKKVGILG-MGAIGKAIARRLIPFGVKLYYWSRHRK 180 >5GUP-L nrPDB Length = 377 Score = 29.3 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 56/154 (36%), Gaps = 21/154 (13%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR---ECPGIEPVCVD 60 ++G V GA +GR V L G++V+ R + +R + I + + Sbjct: 50 SVSGIVATVFGATGFLGRYVVNHLGRMGSQVIVPYRCEPYDTMHLRPMGDLGQIIFMEWN 109 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 D ++ + + +N + L+ E F+ F +++ +A+ Sbjct: 110 GKDKDSIRKVVEH--------SNVVINLVGREWETKNFDFEDVF-------VKIPHAIAQ 154 Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKG 154 GV ++++S + S Y +K Sbjct: 155 VSKEAGVE-KLIHISHLNADIKSP--SRYLRSKA 185 >3H0K-A nrPDB Length = 178 Score = 29.3 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 18/32 (56%), Gaps = 2/32 (6%) Query: 8 RRVLVTGAGKGIGR-GTVQALHATGARVVAVS 38 + +L+TG G G+ + L GA+V+ +S Sbjct: 1 KVILITG-MPGSGKSEFAKLLKERGAKVIVMS 31 >1MLD-A nrPDB Length = 314 Score = 29.3 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 37/123 (30%), Gaps = 27/123 (21%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-VRECPGIEPVCVDLGDWEAT 67 +V V GA GIG+ L + + L + + V DL E Sbjct: 2 KVAVLGASGGIGQPLSLLL-----------KNSPLVSRLTLYDIAHTPGVAADLSHIETR 50 Query: 68 ERALGSVGP---------VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 G +GP D++V A V D F N V ++ Sbjct: 51 ATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTR------DDLFNTNATIVATLTAAC 104 Query: 119 ARG 121 A+ Sbjct: 105 AQH 107 >3D64-A nrPDB Length = 494 Score = 29.3 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 28/96 (29%), Gaps = 19/96 (19%) Query: 2 ELFLAGRRVLVTG----------AGKGIGRGT---------VQALHATGARVVAVSRTQA 42 ++ +AG+ +V G + +G+G G RVV + Sbjct: 272 DVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAAD 331 Query: 43 DLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVD 78 D V + D + ++G D Sbjct: 332 KADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFD 367 >1XRS-A nrPDB Length = 516 Score = 29.3 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 28/138 (20%), Positives = 45/138 (32%), Gaps = 12/138 (8%) Query: 24 VQALHATGARVVAVSRT--QADLD-----SLVRECPGIEPVCVDLGDW-EATERALGSVG 75 A GA V+AV RT Q+ LD + G + EA ++ VG Sbjct: 169 AVAAAKQGADVIAVIRTTGQSLLDYVPYGATTEGFGGTYATQENFRLMREALDKVGAEVG 228 Query: 76 PVDLLVN-NAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNV 134 L N + + + + E D L ++ + R +I + I+N Sbjct: 229 KYIRLCNYCSGLCMPEIAAMGAIERLDVMLNDALYGILFRDINMQRTMIDQNFS-RIIN- 286 Query: 135 SSQCSQRAVTNHSVYCST 152 T Y +T Sbjct: 287 -GFAGVIINTGEDNYLTT 303 >3JTM-A nrPDB Length = 351 Score = 29.0 bits (64), Expect = 1.8, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 44/122 (36%), Gaps = 19/122 (15%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+ + GAG+ IG+ +Q L G ++ R Q L +E Sbjct: 162 LEGKTIGTVGAGR-IGKLLLQRLKPFGCNLLYHDRLQ-MAPELEKETGA----------- 208 Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124 + E + D++V N P E T+ F++ L+ + + ++ Sbjct: 209 KFVEDLNEMLPKCDVIVIN------MPLTEKTRGMFNKELIGKLKKGVLIVNNARGAIME 262 Query: 125 RG 126 R Sbjct: 263 RQ 264 >4OQY-A nrPDB Length = 290 Score = 29.0 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 24/67 (35%), Gaps = 11/67 (16%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD-----------LGDWEAT 67 +G+ V G V +RT + ++LV + P D L D++A Sbjct: 14 MGQAMVNTFLDNGHEVTVWNRTASKAEALVARGAVLAPTVEDALSANELIVLSLTDYDAV 73 Query: 68 ERALGSV 74 L V Sbjct: 74 YAILEPV 80 >4Y4M-A nrPDB Length = 290 Score = 29.0 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 24/66 (36%), Gaps = 5/66 (7%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69 V++ GAG G + L G +VV + R A G + V E + Sbjct: 62 VVIVGAGPS-GLTCARYLAKEGFKVVVLERHLAFGGGTWGGGMGFPYIVV----EEPADE 116 Query: 70 ALGSVG 75 L VG Sbjct: 117 LLREVG 122 >4MIT-A nrPDB Length = 186 Score = 29.0 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 7/52 (13%), Positives = 14/52 (26%), Gaps = 4/52 (7%) Query: 22 GTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGS 73 V+ L G V+ A + L ++ + E + Sbjct: 131 AIVKRLTEQGMTVI----NTAKGEELKNRIKAVKYIECSAKTSENLKTVFDE 178 >5TC4-A nrPDB Length = 316 Score = 29.0 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 27/81 (33%), Gaps = 16/81 (19%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G+ V+V G K +G LH GA E PG + + Sbjct: 159 GKNVVVAGRSKNVGMPIAMLLHTDGAH----------------ERPGGDATVTISHRYTP 202 Query: 67 TERALGSVGPVDLLVNNAAVA 87 E+ D++++ A + Sbjct: 203 KEQLKKHTILADIVISAAGIP 223 >4WEQ-A nrPDB Length = 341 Score = 29.0 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 26/63 (41%), Gaps = 15/63 (23%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVD 78 +G+ + L A G +V+ SR++ ++ G+E D + L G D Sbjct: 172 LGQDAARKLAAMGFKVIGWSRSKRVIE-------GVETY-----DAAGLDAFL---GRTD 216 Query: 79 LLV 81 LV Sbjct: 217 FLV 219 >5MH6-A nrPDB Length = 308 Score = 29.0 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 19/45 (42%), Positives = 24/45 (53%), Gaps = 1/45 (2%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 LAG RV V G G +GRG V A G VV V R+ +D++ Sbjct: 131 FTLAGERVCVVGLGT-LGRGVVDRAAALGMEVVGVRRSGDPVDNV 174 >3G1U-A nrPDB Length = 437 Score = 29.0 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 55/150 (36%), Gaps = 15/150 (10%) Query: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 ++ +AG+ V G G +G+G AL A GARVV + E + V + Sbjct: 207 DVMIAGKTCCVCGYGD-VGKGCAAALRAFGARVVVTEVDPINALQASMEGYQVALVEDVM 265 Query: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV-----NLRAVIQVSQ 116 D + + G D++ ++ + + FD +V N + +++ Sbjct: 266 ADAHIF---VTTTGNDDIITSDHFPHMRDDAIVCNIGHFDTEIQVGWLEANAKEHVEIKP 322 Query: 117 IVARGLIARGV------PGAIVNVSSQCSQ 140 V R + G G +VN+ Sbjct: 323 QVDRYTMENGRHIILLAKGRLVNLGCASGH 352 >4GBJ-A nrPDB Length = 297 Score = 28.6 bits (63), Expect = 2.3, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 21/64 (32%), Gaps = 11/64 (17%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD-----------LGDWEAT 67 +G + L G +V +RT + + L + + +D L D A Sbjct: 16 LGTPIAEILLEAGYELVVWNRTASKAEPLTKLGATVVENAIDAITPGGIVFSVLADDAAV 75 Query: 68 ERAL 71 E Sbjct: 76 EELF 79 >4WLE-A nrPDB Length = 340 Score = 28.6 bits (63), Expect = 2.3, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 37/123 (30%), Gaps = 27/123 (21%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL-VRECPGIEPVCVDLGDWEAT 67 +V V GA GIG+ L + + L + + V DL E Sbjct: 28 KVAVLGASGGIGQPLSLLL-----------KNSPLVSRLTLYDIAHTPGVAADLSHIETK 76 Query: 68 ERALGSVGP---------VDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 G +GP D++V A V D F N V ++ Sbjct: 77 AAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTR------DDLFNTNATIVATLTAAC 130 Query: 119 ARG 121 A+ Sbjct: 131 AQH 133 >5I1W-A nrPDB Length = 500 Score = 28.6 bits (63), Expect = 2.4, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 20/50 (40%), Gaps = 7/50 (14%) Query: 162 VMALELGPHKIRVNAVNPTVVMTSMGQAT-------WSDPHKAKTMLNRI 204 A+E + RVN V+P G + W+DP + + L I Sbjct: 372 SAAMEYIAYGGRVNTVDPAATAVPRGASLKTFYMVAWTDPDEDEEHLRWI 421 >1QYC-A nrPDB Length = 308 Score = 28.6 bits (63), Expect = 2.4, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 31/81 (38%), Gaps = 4/81 (4%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSR--TQADLDSLVRECPGIEPVCVDL--GDW 64 R+L+ GA IGR +A G + R T + + + ++ G Sbjct: 6 RILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSI 65 Query: 65 EATERALGSVGPVDLLVNNAA 85 + + +V VD++++ Sbjct: 66 DDHASLVEAVKNVDVVISTVG 86 >1IM2-A nrPDB Length = 444 Score = 28.6 bits (63), Expect = 2.5, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 20/61 (32%), Gaps = 5/61 (8%) Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEH-VVNAILFLLSDRSGMTTGSTLPVEGGFW 242 T + + I + V +++ I F SD G T+ ++ + Sbjct: 371 TDAVKKIAEAAFRVNEKTENIGARRLHTVMERLMDKISFSASD----MNGQTVNIDAAYV 426 Query: 243 A 243 A Sbjct: 427 A 427 >1I84-U nrPDB Length = 166 Score = 28.6 bits (63), Expect = 2.6, Method: Composition-based stats. Identities = 6/56 (10%), Positives = 20/56 (35%) Query: 24 VQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDL 79 + A G+ V + +++ I+ + D + ++G +++ Sbjct: 4 AKRRAAEGSSNVFSMFDETEIEDFKEAFTVIDQNADGIIDKDDLRETFAAMGRLNV 59 >1YXY-A nrPDB Length = 234 Score = 28.6 bits (63), Expect = 2.6, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 7/62 (11%) Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175 + L+ + G IV S +A+ +Y T G + L A E G IR N Sbjct: 4 KPTKEKLMEQLKGGIIV------SCQALPGEPLYSET-GGIMPLMAKAAQEAGAVGIRAN 56 Query: 176 AV 177 +V Sbjct: 57 SV 58 >2YQ5-A nrPDB Length = 343 Score = 28.6 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 7/20 (35%), Positives = 10/20 (50%) Query: 19 IGRGTVQALHATGARVVAVS 38 IG + A GA+V+A Sbjct: 159 IGSAVAEIFSAMGAKVIAYD 178 >5ZKP-A nrPDB Length = 466 Score = 28.6 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 19/48 (39%), Gaps = 6/48 (12%) Query: 3 LFLAGRRVLVTGAGKG----IGRGTVQALHATGARVVAVSRTQADLDS 46 L + + ++V G+ G + L G V SR A +++ Sbjct: 215 LLMQAKALIVYGSTTGNTEYTAETIARELADAGYEV--DSRDAASVEA 260 >6BMQ-A nrPDB Length = 523 Score = 28.6 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 13/35 (37%) Query: 29 ATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 GA+VV +RT L G DL + Sbjct: 385 EKGAKVVIANRTYERALELAEAIGGKALSLTDLDN 419 >4UUP-A nrPDB Length = 341 Score = 28.6 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 7/20 (35%), Positives = 9/20 (45%) Query: 10 VLVTGAGKGIGRGTVQALHA 29 VL+TGA IG + Sbjct: 7 VLITGAAGQIGYALAFRIAK 26 >5AOV-A nrPDB Length = 336 Score = 28.2 bits (62), Expect = 3.0, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 20/49 (40%), Gaps = 3/49 (6%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG 53 L G+ + + G G+ IG+ + A G + + ++ +E Sbjct: 148 LYGKTIGIVGFGR-IGQAIARR--AKGFNMRILYYSRTRKSQAEKELGA 193 >4OQZ-A nrPDB Length = 289 Score = 28.2 bits (62), Expect = 3.1, Method: Composition-based stats. Identities = 9/38 (23%), Positives = 15/38 (39%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP 56 +G+ A G V +RT + D+LV + Sbjct: 13 MGQAMAAAYLDRGYEVTLWNRTASRADALVARGAKLAA 50 >3FBG-A nrPDB Length = 346 Score = 28.2 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 16/41 (39%), Gaps = 2/41 (4%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHAT-GARVVAVSRTQADLD 45 G+ +L+ G+G + G RV+ + ++ Sbjct: 150 EGKTLLIINGAGGVG-SIATQIAKAYGLRVITTASRNETIE 189 >1Z82-A nrPDB Length = 335 Score = 28.2 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 37/108 (34%), Gaps = 10/108 (9%) Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 ME+ V GAG G Q LH G V+ +R + +D + Sbjct: 13 MEMRF-----FVLGAGS-WGTVFAQMLHENGEEVILWARRKEIVDLINVSHTSPYVEESK 66 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNL 108 + + L + D+LV A+ + + + S +NL Sbjct: 67 ITVRATND--LEEIKKEDILV--IAIPVQYIREHLLRLPVKPSMVLNL 110 >1HE4-A nrPDB Length = 206 Score = 28.2 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 22/65 (33%), Gaps = 2/65 (3%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 +++ + GA G T+ G V + R + L S V D+ Sbjct: 4 KKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPR--PAHVVVGDVLQAADV 61 Query: 68 ERALG 72 ++ + Sbjct: 62 DKTVA 66 >4FSH-A nrPDB Length = 271 Score = 28.2 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 15/36 (41%), Gaps = 1/36 (2%) Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD 45 L+ G G + L G +V ++R+ LD Sbjct: 121 ALILG-SGGSAKALACGLKKQGLKVSVLNRSPRGLD 155 >3R9I-A nrPDB Length = 260 Score = 28.2 bits (62), Expect = 3.5, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 39/107 (36%), Gaps = 11/107 (10%) Query: 8 RRVLVTGAGKGIGR-----GTVQALHATGARVVAVSR--TQADLDSLVRECPGIEPVCVD 60 R ++VT G+G+ L G + V + +LD ++ + V+ Sbjct: 3 RIIVVTSGKGGVGKTTSSAAIATGLAQKGKKTVVIDFAIGLRNLDLIMGCERRVVYDFVN 62 Query: 61 L--GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFE 105 + GD + + +L + A+ + L T+E + + Sbjct: 63 VIQGDATLNQALIKDKRTENLYILPASQTRDKDAL--TREGVAKVLD 107 >1IE3-A nrPDB Length = 312 Score = 28.2 bits (62), Expect = 3.5, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 42/120 (35%), Gaps = 22/120 (18%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT- 67 +V V GA GIG+ L S ++ L + PG V VDL Sbjct: 2 KVAVLGAAGGIGQALALLLKTQ-----LPSGSELSLYDIAPVTPG---VAVDLSHIPTAV 53 Query: 68 -------ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120 E A ++ D+++ +A VA F VN V + Q VA+ Sbjct: 54 KIKGFSGEDATPALEGADVVLISAGVARKPGMDR------SDLFNVNAGIVKNLVQQVAK 107 >4UUM-A nrPDB Length = 341 Score = 28.2 bits (62), Expect = 3.6, Method: Composition-based stats. Identities = 14/99 (14%), Positives = 33/99 (33%), Gaps = 11/99 (11%) Query: 55 EPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114 E + DL + + VD+L ++ F ++ A+D + Sbjct: 188 ESMVADLT-QATFTKEGKTQKVVDVLDHDYVF--DTFFKKIGHRAWDILEHRGFTSAASP 244 Query: 115 SQIVARGLIA---RGVPGAIVNVSSQCSQRAVTNHSVYC 150 ++ + + A PG ++++ V + Y Sbjct: 245 TKAAIQHMKAWLFGTAPGEVLSMG-----IPVPEGNPYG 278 >1V71-A nrPDB Length = 323 Score = 28.2 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 23/59 (38%), Gaps = 9/59 (15%) Query: 31 GARVVAVSRTQADLDSLVRECPGIEPVCVD---------LGDWEATERALGSVGPVDLL 80 G +V+ R + D + + +E E + + G A + VGP+D L Sbjct: 120 GGQVIMYDRYKDDREKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDAL 178 >1OFI-A nrPDB Length = 310 Score = 27.8 bits (61), Expect = 3.9, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 20/61 (32%), Gaps = 5/61 (8%) Query: 184 TSMGQATWSDPHKAKTMLNRIPLGKFAEVEH-VVNAILFLLSDRSGMTTGSTLPVEGGFW 242 T + + I + V +++ I F SD G T+ ++ + Sbjct: 237 TDAVKKIAEAAFRVNEKTENIGARRLHTVMERLMDKISFSASD----MNGQTVNIDAAYV 292 Query: 243 A 243 A Sbjct: 293 A 293 >4TSK-A nrPDB Length = 350 Score = 27.8 bits (61), Expect = 4.4, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 23/62 (37%), Gaps = 3/62 (4%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 LA +R+ V G G G Q L +G VV R + E G + V Sbjct: 15 LADKRIAVIGYGS-QGHAHAQNLRDSGFDVVIGLRPGSSWAK--AEADGFRVMAVGEAVE 71 Query: 65 EA 66 E+ Sbjct: 72 ES 73 >3Q7E-A nrPDB Length = 349 Score = 27.8 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 27/82 (32%), Gaps = 9/82 (10%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVA---VSRTQADLDSLVRECPGIEPVCV 59 + VL G+G GI GAR V S +V+ V + Sbjct: 63 HLFKDKVVLDVGSGTGI---LCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTI 119 Query: 60 DLGDWEATERALGSVGPVDLLV 81 G E E + VD+++ Sbjct: 120 IKGKVEEVELPVE---KVDIII 138 >2Y0D-A nrPDB Length = 478 Score = 27.8 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 17/42 (40%), Gaps = 10/42 (23%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL 47 +G+ LVTGA L G V + QA +D L Sbjct: 16 SGKVGLVTGA----------CLADIGHDVFCLDVDQAKIDIL 47 >1DOD-A nrPDB Length = 394 Score = 27.8 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 25/137 (18%), Positives = 46/137 (33%), Gaps = 12/137 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 + + ++ G+ G Q LH G V + R D +E VDL Sbjct: 1 MKTQVAIIGAGPSGLLLG--QLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMVDLLRE 58 Query: 65 EATERALGSVGPVDLLVNNAA-VALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 +R + D LV+ +A + + V + +V++ + + Sbjct: 59 AGVDRRMAR----DGLVHEGVEIAFAGQRRRIDLKRLSGGKTVTVYGQTEVTRDL---ME 111 Query: 124 ARGVPGAIVNVSSQCSQ 140 AR GA Q ++ Sbjct: 112 AREACGA--TTVYQAAE 126 >4U4E-A nrPDB Length = 383 Score = 27.4 bits (60), Expect = 5.3, Method: Composition-based stats. Identities = 13/92 (14%), Positives = 34/92 (36%), Gaps = 4/92 (4%) Query: 84 AAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA--RGVPGAIVNVSSQCSQR 141 A V L + ++F + ++L + ++ ++ R PG +++ Sbjct: 266 AGVTHDDIDLAMIYDSFTYTVLLSLEDLGFCAKGEGGAFVSGQRTAPGGDFPMNTNGGGL 325 Query: 142 AVTNHSVYCSTKGALDMLTKVMALELGPHKIR 173 + T+ +Y A+ + + + IR Sbjct: 326 SYTHPGMYGM--FAIIEAVRQLRHDYADQGIR 355 >5NUE-A nrPDB Length = 332 Score = 27.4 bits (60), Expect = 5.4, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 36/123 (29%), Gaps = 19/123 (15%) Query: 9 RVLVTGAGKGIGRGTVQALHA---TGAR--VVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 RVLVTGA IG V + GA V+ D+ G++ +D Sbjct: 7 RVLVTGAAGQIGYALVPMIARGIMLGADQPVILHML---DIPPAAEALNGVKMELIDAAF 63 Query: 64 WE-----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIV 118 AT A+ V++ V + N+ + + Sbjct: 64 PLLKGVVATTDAVEGCTGVNVAVMVGGFPRKEGMER------KDVMSKNVSIYKSQAAAL 117 Query: 119 ARG 121 + Sbjct: 118 EKH 120 >4DLL-A nrPDB Length = 320 Score = 27.4 bits (60), Expect = 5.5, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 13/41 (31%) Query: 15 AGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE 55 +G + L G + +RT A SL I Sbjct: 38 GTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIH 78 >3UOG-A nrPDB Length = 363 Score = 27.4 bits (60), Expect = 5.7, Method: Composition-based stats. Identities = 30/125 (24%), Positives = 43/125 (34%), Gaps = 15/125 (12%) Query: 6 AGRRVLV--TGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 AG RV+V TG G +A TGA V+ S ++ LD + D Sbjct: 189 AGDRVVVQGTGGVALFGLQIAKA---TGAEVIVTSSSREKLDR-AFALGADHGINRLEED 244 Query: 64 W-EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV---IQVSQIVA 119 W E G G +L L Q V + +++ V +VS V Sbjct: 245 WVERVYALTGDRGADHILEIAGGAGLGQSLKAVAPDG-----RISVIGVLEGFEVSGPVG 299 Query: 120 RGLIA 124 L+ Sbjct: 300 PLLLK 304 >4E0B-A nrPDB Length = 313 Score = 27.4 bits (60), Expect = 5.7, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 13/34 (38%), Gaps = 4/34 (11%) Query: 8 RRVLVTGAGKGIGRGTVQALHA---TGARVVAVS 38 + ++ GA GIG+ L G+ + Sbjct: 5 KVAVI-GAAGGIGQALALLLKNRLPAGSDLALYD 37 >5VVW-A nrPDB Length = 315 Score = 27.4 bits (60), Expect = 6.1, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 25/85 (29%), Gaps = 14/85 (16%) Query: 18 GIGRG----TVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGS 73 GIG + L G V + + + + + + + Sbjct: 15 GIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQIFIGHQAENADGA------ 68 Query: 74 VGPVDLLVNNAAVALLQPFLEVTKE 98 D+LV ++A+ P + E Sbjct: 69 ----DVLVVSSAINRANPEVASALE 89 >4XRR-A nrPDB Length = 456 Score = 27.4 bits (60), Expect = 6.1, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 30/95 (31%), Gaps = 7/95 (7%) Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL--VRECPGIEPVCVDLGDWEATE 68 +V +G L GA VVAV + L R + + D AT Sbjct: 18 VVIAGAGYVGTCLAVTLAGRGAEVVAVDSDPGTVADLRAGRCRLPEPGLAGAVRDLAATG 77 Query: 69 RALGS-----VGPVDLLVNNAAVALLQPFLEVTKE 98 R S VG D+++ VT + Sbjct: 78 RLTASTSYDPVGAADVVIVTVGTPTDAGHEMVTDQ 112 >4OM8-A nrPDB Length = 309 Score = 27.4 bits (60), Expect = 6.3, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 27/74 (36%), Gaps = 9/74 (12%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLD---------SLVRECPGIEPVCVDLGDWEATER 69 +G G L G +VVA A ++ V + GI +G T+ Sbjct: 13 MGPGMAARLARGGLQVVAYDVAPAAIERARSMLSVAETVLDALGIALPSAGVGTVRFTDD 72 Query: 70 ALGSVGPVDLLVNN 83 +V DL++ N Sbjct: 73 IGDAVSGADLVIEN 86 >3RI6-A nrPDB Length = 430 Score = 27.4 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 45/137 (32%), Gaps = 19/137 (13%) Query: 13 TGA------GKGIGR---GTVQALHATGARVVAVSRTQADLDSLVRECP---GIEPVCVD 60 TGA G G+ L G VV R SL ++ GIE VD Sbjct: 95 TGALGVLALGSGMAAISTAI-LTLARAGDSVVTTDRLFGHTLSLFQKTLPSFGIEVRFVD 153 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTK-EAFDRSFEVNLRAVIQVSQIVA 119 + D A E A + L + P L+V EA + ++ + + Sbjct: 154 VMDSLAVEHACDETTKLLFL-----ETISNPQLQVADLEALSKVVHAKGIPLVVDTTMTP 208 Query: 120 RGLIARGVPGAIVNVSS 136 L+ G + V S Sbjct: 209 PYLLEAKRLGVDIEVLS 225 >2DQ4-A nrPDB Length = 343 Score = 27.4 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVS 38 +G+ VL+TGAG IG + A+GA + VS Sbjct: 164 SGKSVLITGAGP-IGLMAAMVVRASGAGPILVS 195 >5LV5-A nrPDB Length = 403 Score = 27.4 bits (60), Expect = 6.6, Method: Composition-based stats. Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 6/67 (8%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGA-RVVAVSRTQ--ADLDSLVRECPGIEPVCVDL 61 L G+ VL GAG GI GA RV AV + +VR + V V Sbjct: 109 LRGKTVLDVGAGTGI---LSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLP 165 Query: 62 GDWEATE 68 G E E Sbjct: 166 GPVETVE 172 >5A9T-A nrPDB Length = 290 Score = 27.0 bits (59), Expect = 6.7, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 19/50 (38%), Gaps = 1/50 (2%) Query: 12 VTGAGKG-IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60 VT AG G +G AL G V +R+ LV + VD Sbjct: 8 VTVAGLGPMGSALAAALLDRGHDVTVWNRSPGKAAPLVAKGARQADDIVD 57 >1UUF-A nrPDB Length = 369 Score = 27.0 bits (59), Expect = 6.8, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 24/56 (42%), Gaps = 8/56 (14%) Query: 28 HATGARVVAVSRTQADLDSLVRECPGIEPVCVD-LGDWEATERALGSVGPVDLLVN 82 HA GA VVA + ++A ++ + + D + + + + D ++N Sbjct: 215 HAMGAHVVAFTTSEAKREA-------AKALGADEVVNSRNADEMAAHLKSFDFILN 263 >2UYY-A nrPDB Length = 316 Score = 27.0 bits (59), Expect = 6.9, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 37/99 (37%), Gaps = 16/99 (16%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVREC------PGIEPVCVD-----LGDWEAT 67 +G G V L G V +RT D ++E P D + D +A Sbjct: 41 MGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAA 100 Query: 68 ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEV 106 + + +GP +L + + +++++ D E+ Sbjct: 101 KDLV--LGPSGVL---QGIRPGKCYVDMSTVDADTVTEL 134 >4EEZ-A nrPDB Length = 348 Score = 27.0 bits (59), Expect = 7.0, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 26/73 (35%), Gaps = 3/73 (4%) Query: 15 AGKGIGRGTVQALHAT--GARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALG 72 G+G GA+V+AV Q L+ + + D+ + ++ G Sbjct: 171 GAGGLGN-LAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVTINSGDVNPVDEIKKITG 229 Query: 73 SVGPVDLLVNNAA 85 +G +V A Sbjct: 230 GLGVQSAIVCAVA 242 >4MLQ-A nrPDB Length = 312 Score = 27.0 bits (59), Expect = 7.1, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 22/48 (45%), Gaps = 11/48 (22%) Query: 6 AGRRVL---VTG----AGKGIGRGTVQALHATGARVVAVSRTQADLDS 46 G+ + +TG A IG + L + GA+++ R + +LD Sbjct: 269 DGKTIYKEHITGKDPIA---IGSEAAERLTSQGAKLLI-DRVKEELDK 312 >3DQQ-A nrPDB Length = 421 Score = 27.0 bits (59), Expect = 7.1, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 16/50 (32%) Query: 131 IVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180 I +S + A+ A++ L ++A L I V Sbjct: 313 ISATASTQALAAIQQQYGATEASHAVEALFSLLAARLAEGGITRFIVAGG 362 >4A26-A nrPDB Length = 300 Score = 27.0 bits (59), Expect = 7.2, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 17/43 (39%) Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD 45 + +AG+R +V G +G L A V V + D Sbjct: 161 IEMAGKRAVVLGRSNIVGAPVAALLMKENATVTIVHSGTSTED 203 >6IH4-A nrPDB Length = 338 Score = 27.0 bits (59), Expect = 7.3, Method: Composition-based stats. Identities = 20/148 (13%), Positives = 52/148 (35%), Gaps = 29/148 (19%) Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 L G+ + + G +GR Q L G + + + L++ + ++ V +D Sbjct: 142 GLTGKTLGIRG-MGAVGRAIAQRLA--GFEMNLLYCDEIPLNAEQEKAWHVQRVTLD--- 195 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + D +V P + + E ++L ++++ + Sbjct: 196 --------ELLEKCDYVV---------PMVPMAAE------TLHLIDATALAKMKTGSYL 232 Query: 124 ARGVPGAIVNVSSQCSQRAVTNHSVYCS 151 G++V+ ++ + A + Y + Sbjct: 233 INACRGSVVDENAVIAALASGKLAGYAA 260 >5XW3-A nrPDB Length = 315 Score = 27.0 bits (59), Expect = 7.5, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 27/111 (24%), Gaps = 37/111 (33%) Query: 13 TGAGKGIGRGTV---------------------QALHATGARVVAVSRTQ------ADLD 45 T GIG + + A GA VV Q A Sbjct: 71 TAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAK 130 Query: 46 SLVRECPGIEPVCVDLGDWEATERALGSVGP---------VDLLVNNAAVA 87 LV E P + ++GP +++ V A Sbjct: 131 ELVNEIPNS-YSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAGTG 180 >2OHJ-A nrPDB Length = 404 Score = 27.0 bits (59), Expect = 7.5, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 12/32 (37%), Gaps = 3/32 (9%) Query: 8 RRVLVTGAGKGIGRG---TVQALHATGARVVA 36 R+ LV G+ G G + L G V Sbjct: 344 RKALVFGSMGGNGGATGTMKELLAEAGFDVAC 375 >6DKH-A nrPDB Length = 346 Score = 27.0 bits (59), Expect = 7.6, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 4/75 (5%) Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64 L G+RV ++G G IG V A+ GA + + SL +E + Sbjct: 171 LQGKRVFISGVGP-IGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMG---ADVLVNPQN 226 Query: 65 EATERALGSVGPVDL 79 + + G D+ Sbjct: 227 DDMDHWKAEKGYFDV 241 >5WYK-3B nrPDB Length = 327 Score = 27.0 bits (59), Expect = 7.6, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 44/131 (33%), Gaps = 29/131 (22%) Query: 7 GRRVLVTGAGKGIGRGTV-QALHATG--ARVVAVSRTQADLDSLVRECPGIEPVCVDLGD 63 G++VL GA G V + G V R +L S+ ++ P I P+ D Sbjct: 167 GKKVLYLGAASGTSVSHVSDVVGPEGVVYAVEFSHRPGRELISMAKKRPNIIPIIEDARH 226 Query: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 + + G VD + F +V + R +N + Sbjct: 227 PQKYRMLI---GMVDCV-----------FADVAQPDQARIIALN------------SHMF 260 Query: 124 ARGVPGAIVNV 134 + G ++++ Sbjct: 261 LKDQGGVVISI 271 >5OCM-A nrPDB Length = 291 Score = 27.0 bits (59), Expect = 7.6, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 24/78 (30%), Gaps = 14/78 (17%) Query: 19 IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD-----------LGDWEAT 67 +G+ A G +R++ L + + D + D A Sbjct: 14 MGQALAGAFLKDGHATTVWNRSEGKAGQLAEQGAVLASSARDAAEASPLVVVCVSDHAAV 73 Query: 68 ERALGSVGPV---DLLVN 82 L +G V +LVN Sbjct: 74 RAVLDPLGDVLAGRVLVN 91 >4PZE-A nrPDB Length = 284 Score = 27.0 bits (59), Expect = 7.8, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 63/191 (32%), Gaps = 22/191 (11%) Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEAT 67 R V + GAG +G G QA G VV V + A + V + Sbjct: 4 RTVGIVGAGT-MGNGIAQACAVVGLNVVMVDISDAAVQKGVATVASSLDRLIKKEKLTEA 62 Query: 68 ERA-----------LGSVGPVDLLVNNAAVALL---QPFLEVTKEAFDRSFEVNLRAVIQ 113 ++A + D+++ A + ++ + + + I Sbjct: 63 DKASALARIKGSTSYDDLKATDIVIEAATENYDLKVKILKQIDGIVGENVIIASNTSSIS 122 Query: 114 VSQIVARGLIARGVPG-AIVNVSSQCSQRAVT-NHSVYCSTKGALDMLTKVMALELGPHK 171 ++++ A A G N + + +T A++ L+K +LG + Sbjct: 123 ITKLAAVTSRADRFIGMHFFNPVPVMALVELIRGLQTSDTTHAAVEALSK----QLGKYP 178 Query: 172 IRVNAVNPTVV 182 I V +P V Sbjct: 179 ITVKN-SPGFV 188 >3PII-A nrPDB Length = 339 Score = 27.0 bits (59), Expect = 8.1, Method: Composition-based stats. Identities = 23/80 (28%), Positives = 29/80 (36%), Gaps = 13/80 (16%) Query: 12 VTGAG----------KGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL 61 VTGA G G VQ A G VVAV L+ L +E + V+ Sbjct: 159 VTGAKPGEWVAIYGIGGFGHVAVQYAKAMGLNVVAVDIGDEKLE-LAKELGA--DLVVNP 215 Query: 62 GDWEATERALGSVGPVDLLV 81 +A + VG V V Sbjct: 216 LKEDAAKFMKEKVGGVHAAV 235 >5A3V-A nrPDB Length = 329 Score = 27.0 bits (59), Expect = 8.4, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 31/99 (31%), Gaps = 12/99 (12%) Query: 6 AGRRV--LVTGAGKGIGRGTVQALHA-TGARVVAV--SRTQADLDSLVRECPGIEPVCVD 60 G++ LVT A G+G L A V A +R + SL + +D Sbjct: 153 TGKKANILVTAASGGVG-HYAVQLAKLANAHVTATCGARNIEFVKSLGADE------VLD 205 Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEA 99 E S D +V+ A F E Sbjct: 206 YKTPEGAALKSPSGKKYDAVVHCANGIPFSVFEPNLSEN 244 >3CCF-A nrPDB Length = 279 Score = 27.0 bits (59), Expect = 8.4, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 27/78 (34%), Gaps = 10/78 (12%) Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEA 66 G +L G G G + + +GA V+ ++ + P + D + Sbjct: 58 GEFILDLGCGTGQ---LTEKIAQSGAEVLGTDNAATMIEKARQNYPHLHFDVADARN--- 111 Query: 67 TERALGSVGPVDLLVNNA 84 P+D + +NA Sbjct: 112 ----FRVDKPLDAVFSNA 125 >1RK2-A nrPDB Length = 309 Score = 27.0 bits (59), Expect = 8.4, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 20/66 (30%), Gaps = 5/66 (7%) Query: 107 NLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGA-----LDMLTK 161 N+ + + + I N S+ Q SV + K A + L Sbjct: 108 NVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNP 167 Query: 162 VMALEL 167 A EL Sbjct: 168 APAREL 173 >2WEK-A nrPDB Length = 341 Score = 27.0 bits (59), Expect = 8.5, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 15/39 (38%), Gaps = 2/39 (5%) Query: 6 AGRRVLVTGAGKGIGRGTVQALH-ATGARVVAVSRTQAD 43 G++VLVT A G G+ L V+ + Sbjct: 142 EGKKVLVTAAAGGTGQ-FAMQLSKKAKCHVIGTCSSDEK 179 >4Y4N-A nrPDB Length = 286 Score = 27.0 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 22/67 (32%), Gaps = 6/67 (8%) Query: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATE 68 +V G G+ + + G +VV + R A G + V E + Sbjct: 55 VAIVGGGPSGL--TAARYIAKEGYKVVVLERHLAFGGGTWGGGMGFPYIVV----EEPAD 108 Query: 69 RALGSVG 75 L VG Sbjct: 109 EILREVG 115 >6AZ1-E nrPDB Length = 273 Score = 26.6 bits (58), Expect = 8.9, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 20/59 (33%), Gaps = 4/59 (6%) Query: 6 AGRRVLVTGAG-KG-IGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLG 62 G+ V+VTG +G IG V+ GA A I + DL Sbjct: 174 QGKAVIVTGGANRGRIG-EIVKVECHPGAF-NIAHLKDASGAEFATRAANIFVIGKDLN 230 >2X3N-A nrPDB Length = 399 Score = 26.6 bits (58), Expect = 9.1, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 16/35 (45%), Gaps = 3/35 (8%) Query: 10 VLVTGAGKGIGRGT-VQALHATGARVVAVSRTQAD 43 VL+ G GIG L G RVV V + + + Sbjct: 9 VLINGC--GIGGAMLAYLLGRQGHRVVVVEQARRE 41 >3KAQ-A nrPDB Length = 147 Score = 26.6 bits (58), Expect = 9.4, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 20/51 (39%), Gaps = 4/51 (7%) Query: 8 RRVLVTGAGKGIGRGTVQAL----HATGARVVAVSRTQADLDSLVRECPGI 54 + +++ G+ G Q L A G V ++ +A D+L + Sbjct: 2 KVLILFGSSTGNTESIAQKLEELVAAGGHEVTLLNAAEASADNLADGYDAV 52 >1GG0-A nrPDB Length = 284 Score = 26.6 bits (58), Expect = 9.4, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 6/71 (8%) Query: 14 GAGKGIGRGTVQALHATGARVVAVSRT-QADLDSLVRECPGIEPVCV-----DLGDWEAT 67 GA G R V L G V +A D +C G + + L +A Sbjct: 211 GAASGGRRAQVAELARAGMAVGLAGLFIEAHPDPEHAKCDGPSALPLAKLEPFLKQMKAI 270 Query: 68 ERALGSVGPVD 78 + + +D Sbjct: 271 DDLVKGFEELD 281 >5UI4-A nrPDB Length = 159 Score = 26.6 bits (58), Expect = 9.7, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 20/59 (33%), Gaps = 7/59 (11%) Query: 14 GAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALG 72 G +G+ ++ G R+V + QA D L VDL D + Sbjct: 22 GVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKE-------HYVDLKDRPFFAGLVK 73 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.166 0.489 Lambda K H 0.267 0.0509 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,078,093 Number of Sequences: 36641 Number of extensions: 491798 Number of successful extensions: 3436 Number of sequences better than 10.0: 501 Number of HSP's better than 10.0 without gapping: 467 Number of HSP's successfully gapped in prelim test: 246 Number of HSP's that attempted gapping in prelim test: 2030 Number of HSP's gapped (non-prelim): 764 length of query: 244 length of database: 10,336,785 effective HSP length: 94 effective length of query: 150 effective length of database: 6,892,531 effective search space: 1033879650 effective search space used: 1033879650 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 58 (26.6 bits)