BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q6VVX0 (501 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3DL9-A nrPDB 979 0.0 3TBG-A nrPDB 326 1e-89 4H1N-A nrPDB 308 4e-84 3E6I-A nrPDB 305 3e-83 1N6B-A nrPDB 305 4e-83 2NNH-A nrPDB 304 5e-83 4GQS-A nrPDB 299 2e-81 5E0E-A nrPDB 297 7e-81 2PG7-A nrPDB 296 1e-80 5E58-A nrPDB 295 3e-80 5W0C-A nrPDB 292 3e-79 3IBD-A nrPDB 278 3e-75 6B82-A nrPDB 272 2e-73 4R20-A nrPDB 248 4e-66 4R1Z-A nrPDB 240 8e-64 5UYS-A nrPDB 218 6e-57 6DWN-A nrPDB 216 1e-56 2HI4-A nrPDB 215 3e-56 6IQ5-A nrPDB 208 4e-54 5VBU-A nrPDB 182 4e-46 3QZ1-A nrPDB 167 9e-42 5YLW-A nrPDB 138 5e-33 6DA2-A nrPDB 130 1e-30 5VEU-A nrPDB 124 9e-29 6C94-A nrPDB 108 4e-24 2VE3-A nrPDB 107 2e-23 3K9V-A nrPDB 101 8e-22 3MDV-A nrPDB 94 2e-19 4KPA-A nrPDB 89 4e-18 3EL3-A nrPDB 89 5e-18 3S79-A nrPDB 80 2e-15 6AYB-A nrPDB 77 1e-14 6M7X-A nrPDB 75 9e-14 4ZGX-A nrPDB 74 2e-13 3N9Z-A nrPDB 73 3e-13 5IT1-A nrPDB 69 4e-12 3MZS-A nrPDB 68 1e-11 5NWS-A nrPDB 67 2e-11 4OQS-A nrPDB 64 1e-10 3TYW-A nrPDB 64 2e-10 5YSW-A nrPDB 64 2e-10 3JUS-A nrPDB 63 3e-10 2Z36-A nrPDB 63 3e-10 4OQR-A nrPDB 62 6e-10 1WIY-A nrPDB 62 6e-10 3MGX-A nrPDB 61 9e-10 5DQN-A nrPDB 60 2e-09 6GMF-A nrPDB 60 3e-09 4YZR-A nrPDB 59 5e-09 3P3Z-A nrPDB 59 6e-09 2VZM-A nrPDB 59 6e-09 4WMZ-A nrPDB 58 8e-09 5L94-A nrPDB 58 8e-09 5FSA-A nrPDB 58 9e-09 3ABB-A nrPDB 58 9e-09 3A50-A nrPDB 58 1e-08 5OFQ-A nrPDB 58 1e-08 1Q5D-A nrPDB 58 1e-08 4GGV-A nrPDB 57 1e-08 2WX2-A nrPDB 57 2e-08 1ODO-A nrPDB 57 3e-08 5CJE-A nrPDB 56 3e-08 3L4D-A nrPDB 56 3e-08 4UBS-A nrPDB 56 4e-08 3ABA-A nrPDB 55 5e-08 3A1L-A nrPDB 55 5e-08 6B11-A nrPDB 55 8e-08 3R9C-A nrPDB 55 8e-08 3IVY-A nrPDB 54 1e-07 2RFC-A nrPDB 54 1e-07 5JLC-A nrPDB 54 2e-07 2Y5N-A nrPDB 53 3e-07 2ZBZ-A nrPDB 53 3e-07 6CR2-A nrPDB 53 4e-07 1EHE-A nrPDB 51 1e-06 4TRI-A nrPDB 51 1e-06 1UE8-A nrPDB 50 2e-06 2W0A-A nrPDB 50 2e-06 6FYJ-A nrPDB 50 2e-06 5EX6-C nrPDB 50 3e-06 4WPZ-A nrPDB 50 3e-06 1CPT-A nrPDB 50 3e-06 5HIW-A nrPDB 49 5e-06 2FR7-A nrPDB 49 5e-06 5VWS-A nrPDB 49 7e-06 6GK6-A nrPDB 48 1e-05 4MM0-A nrPDB 48 1e-05 3AWQ-A nrPDB 48 1e-05 4RM4-A nrPDB 47 2e-05 5XW2-A nrPDB 47 2e-05 6CVC-A nrPDB 47 3e-05 4DO1-A nrPDB 46 3e-05 6GII-A nrPDB 46 3e-05 5FOI-A nrPDB 46 3e-05 5Y1I-A nrPDB 46 4e-05 2X9P-A nrPDB 46 4e-05 4XE3-A nrPDB 45 5e-05 1LG9-A nrPDB 45 6e-05 1UED-A nrPDB 45 6e-05 3EJB-B nrPDB 45 7e-05 5LIV-A nrPDB 45 7e-05 5FYF-A nrPDB 45 7e-05 2X2N-A nrPDB 45 8e-05 6M7L-A nrPDB 45 9e-05 2WIO-A nrPDB 45 9e-05 6F88-A nrPDB 45 1e-04 6F0B-A nrPDB 45 1e-04 5Z9I-A nrPDB 45 1e-04 1Z8P-A nrPDB 44 1e-04 3RWL-A nrPDB 44 1e-04 4JBT-A nrPDB 44 2e-04 6G71-A nrPDB 44 2e-04 4Z5P-A nrPDB 44 2e-04 2UUQ-A nrPDB 44 2e-04 5YHJ-A nrPDB 43 2e-04 4YT3-A nrPDB 43 4e-04 6FSH-A nrPDB 42 6e-04 2WM5-A nrPDB 42 7e-04 4TX3-A nrPDB 42 8e-04 6A7J-A nrPDB 41 0.001 5LIE-A nrPDB 41 0.001 5XNT-A nrPDB 41 0.001 6A7I-A nrPDB 41 0.001 3TKT-A nrPDB 41 0.001 2XKR-A nrPDB 41 0.002 5M0P-A nrPDB 40 0.002 3WVS-A nrPDB 40 0.002 1GWI-A nrPDB 40 0.003 4Z5Q-A nrPDB 39 0.004 2ZQJ-A nrPDB 39 0.005 6HQD-A nrPDB 39 0.007 3SN5-A nrPDB 37 0.014 1F4U-A nrPDB 37 0.014 5DE9-A nrPDB 37 0.022 2NZA-A nrPDB 36 0.032 6DCD-A nrPDB 36 0.034 5L1U-A nrPDB 36 0.034 3NC3-A nrPDB 36 0.034 2WIY-A nrPDB 36 0.050 5HDI-A nrPDB 35 0.064 3OO3-A nrPDB 35 0.067 2QBO-A nrPDB 35 0.069 6HQW-A nrPDB 35 0.074 5D3U-A nrPDB 34 0.16 6HQG-A nrPDB 34 0.17 2IAG-A nrPDB 32 0.60 2GLF-A nrPDB 31 1.6 6BLD-A nrPDB 30 1.9 2WV5-A nrPDB 30 1.9 5H5M-A nrPDB 29 3.9 6D6R-H nrPDB 28 9.2 >3DL9-A nrPDB Length = 479 Score = 979 bits (2532), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/470 (100%), Positives = 470/470 (100%) Query: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG 91 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG Sbjct: 6 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG 65 Query: 92 YDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQ 151 YDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQ Sbjct: 66 YDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQ 125 Query: 152 KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211 KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI Sbjct: 126 KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 185 Query: 212 ELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQ 271 ELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQ Sbjct: 186 ELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQ 245 Query: 272 LPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN 331 LPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN Sbjct: 246 LPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN 305 Query: 332 IQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 391 IQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG Sbjct: 306 IQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 365 Query: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE 451 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE Sbjct: 366 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE 425 Query: 452 HLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 HLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR Sbjct: 426 HLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 475 >3TBG-A nrPDB Length = 479 Score = 326 bits (836), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 180/438 (41%), Positives = 246/438 (56%), Gaps = 14/438 (3%) Query: 73 YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMGGLLNSRY 129 +G++FSL L VVLNG V+E LV E ADRP +P+ + + G+ +RY Sbjct: 43 FGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARY 102 Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 G W + RR +V++ R G G+KS E + EE A + GRPF L+ AVSN Sbjct: 103 GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSN 162 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + + G RF Y+D F +++L E ++ + + NA P + +P + L Sbjct: 163 VIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQ 222 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 A + L E Q P+ +A+L EM++ K +P S+F+ ENL V +L Sbjct: 223 KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFS 282 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG TT+ L W +L M L+P++Q +VQ+EID ++G +P D+ MPYT AV+HEV Sbjct: 283 AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ 342 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 RF +IVPLG+ H TS D V+G+ IPKGTT+ITNL SV DE W P FHPE FLD+ Sbjct: 343 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ 402 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR----- 484 G+F K EA +PFS GRR CLGE LARME+FLFFT+LLQ F VP +PR Sbjct: 403 GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS-----VPTGQPRPSHHG 457 Query: 485 -LGMTLQPQPYLICAERR 501 + P PY +CA R Sbjct: 458 VFAFLVSPSPYELCAVPR 475 >4H1N-A nrPDB Length = 479 Score = 308 bits (789), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 173/452 (38%), Positives = 263/452 (58%), Gaps = 14/452 (3%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP LP +GN+ + L ++R + + YG++F++ LG VVL G D ++E Sbjct: 11 LPPGPSPLPVLGNLLQMDRKGLL-RSFLRLREK-YGDVFTVYLGSRPVVVLCGTDAIREA 68 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 LV Q+E F+ R + + + + G++ + G W RR ++ + R FG G++S E +I Sbjct: 69 LVDQAEAFSGRGKIAVVDPIFQGYGVIFAN-GERWRALRRFSLATMRDFGMGKRSVEERI 127 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 EE + + + KG D L + SNI I+FG+RF Y+D F +++LF ++ Sbjct: 128 QEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSF 187 Query: 219 ELAASASVFLYNAFPWIGILPF--GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 L +S S ++ F G L + G H+Q++RN + F+ + +EK P P+ F Sbjct: 188 SLISSFSSQVFELFS--GFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDF 245 Query: 277 VDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336 +D YL M++ K+DPSS F +NLI +V L AGTETT+ LR+ L M YP++ +V Sbjct: 246 IDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERV 305 Query: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396 QKEI+ ++G + P+ DD+ KMPYT+AV+HE+ R +++P G+ H ++D RGY IPK Sbjct: 306 QKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPK 365 Query: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456 T V L S D +Y+ P F+P FLD++G + E +PFSLG+R CLGE +AR Sbjct: 366 NTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIART 425 Query: 457 EMFLFFTALLQRFHLHFPHELVP----DLKPR 484 E+FLFFT +LQ F + P VP DL PR Sbjct: 426 ELFLFFTTILQNFSIASP---VPPEDIDLTPR 454 >3E6I-A nrPDB Length = 476 Score = 305 bits (781), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 170/465 (36%), Positives = 266/465 (57%), Gaps = 12/465 (2%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP LP IGN++ L + +P + R +Q +G +F+L +G VV++GY VKE Sbjct: 11 LPPGPFPLPIIGNLFQLELKN-IPKSFTR-LAQRFGPVFTLYVGSQRMVVMHGYKAVKEA 68 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 L+ + F+ R LP F G + N+ G W D RR ++ + R +G G++ ES+I Sbjct: 69 LLDYKDEFSGRGDLPAFHAHRDRGIIFNN--GPTWKDIRRFSLTTLRNYGMGKQGNESRI 126 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 E F +A+ +G+PFD LI A N+ I+F + F Y D F ++ LF+EN Sbjct: 127 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF 186 Query: 219 ELAASASVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277 L ++ + LYN FP ++ LP G H+++ +N A V +++S +++ + P P+ Sbjct: 187 HLLSTPWLQLYNNFPSFLHYLP-GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLT 245 Query: 278 DAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQ 337 D L EM++ K+ ++ + + +V +L AGTETT+ LR+ +L + YP I+ ++ Sbjct: 246 DCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLH 305 Query: 338 KEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKG 397 +EID ++GP+ P+ D+ +MPY +AV+HE+ RF +VP + H + D + RGY IPKG Sbjct: 306 EEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKG 365 Query: 398 TTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 T V+ L SV +D + + DPE F PE FL+ +G F + PFS G+R C GE LARME Sbjct: 366 TVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARME 425 Query: 458 MFLFFTALLQRFHLH---FPHELVPDLKP-RLGMTLQPQPYLICA 498 +FL A+LQ F+L P ++ DL P +G P Y +C Sbjct: 426 LFLLLCAILQHFNLKPLVDPKDI--DLSPIHIGFGCIPPRYKLCV 468 >1N6B-A nrPDB Length = 473 Score = 305 bits (780), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 166/434 (38%), Positives = 255/434 (58%), Gaps = 6/434 (1%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP P IGNI + A + K S+ YG +F++ LG TVVL+GY+ VKE Sbjct: 11 LPPGPTPFPIIGNILQIDAKD--ISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEA 68 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 LV E FA R +P+ K++K G+ S + W + RR ++ + R FG G++S E +I Sbjct: 69 LVDLGEEFAGRGSVPILEKVSKGLGIAFSN-AKTWKEMRRFSLMTLRNFGMGKRSIEDRI 127 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 EE + + + P D ++ A N+ +IF RF Y+D +F ++E ENV Sbjct: 128 QEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLHENV 187 Query: 219 ELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD 278 EL + + +YN FP + G H+ L +NA + +F+ +++ P+ F+D Sbjct: 188 ELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFID 247 Query: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338 +L +M+Q N F+ E+L+ +V +L AGTETT+ LR+++L + +P + +VQ+ Sbjct: 248 CFLIKMEQENN---LEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQE 304 Query: 339 EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGT 398 EI+ ++G + P D+ +MPYT+AV+HE+ RF +++P + HA + D R Y IPKGT Sbjct: 305 EIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGT 364 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 +IT+L SV DEK + +P+VF P FLD SG F K + +PFS G+R C+GE LARME+ Sbjct: 365 DIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMEL 424 Query: 459 FLFFTALLQRFHLH 472 FLF T++LQ F L Sbjct: 425 FLFLTSILQNFKLQ 438 >2NNH-A nrPDB Length = 476 Score = 304 bits (779), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 166/466 (35%), Positives = 265/466 (56%), Gaps = 15/466 (3%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP LP IGN+ + S+VYG +F++ G VV +GY+ VKE Sbjct: 11 LPPGPTPLPIIGNMLQIDVKDICKS--FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEA 68 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 L+ E F+ R P+ ++TK G+++S G+ W + RR ++ + R FG G++S E ++ Sbjct: 69 LIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRWKEIRRFSLTTLRNFGMGKRSIEDRV 127 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 EE + + K P D ++ A N+ ++F +RF Y+D +F +++ F+EN Sbjct: 128 QEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENF 187 Query: 219 ELAASASVFLYNAFPW-IGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277 + S + + N FP I P G H ++ +N A+ ++ +++ + P+ F+ Sbjct: 188 RILNSPWIQVCNNFPLLIDCFP-GTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFI 246 Query: 278 DAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQ 337 D +L +M+Q K++ S F+ ENL+ +V +L +AGTETT+ LR+ +L + +P + +VQ Sbjct: 247 DCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQ 306 Query: 338 KEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKG 397 +EID ++G + P D+ MPYT+AV+HE+ R+ ++VP G+ HA + D R Y IPKG Sbjct: 307 EEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKG 366 Query: 398 TTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 TT++ L SV D+K + +P +F P FLD +G F K + +PFS G+R C GE LARME Sbjct: 367 TTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARME 426 Query: 458 MFLFFTALLQRFHLHFPHELVPDLKP------RLGMTLQPQPYLIC 497 +FLF T +LQ F+L + V DLK G+ P Y IC Sbjct: 427 LFLFLTTILQNFNL----KSVDDLKNLNTTAVTKGIVSLPPSYQIC 468 >4GQS-A nrPDB Length = 477 Score = 299 bits (766), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 162/436 (37%), Positives = 256/436 (58%), Gaps = 9/436 (2%) Query: 39 FPPGPPGLPFIGNIYSLA---ASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVV 95 PPGP LP IGNI + S L ++ S++YG +F+L G VVL+GY+VV Sbjct: 12 LPPGPTPLPVIGNILQIDIKDVSKSLTNL-----SKIYGPVFTLYFGLERMVVLHGYEVV 66 Query: 96 KECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFE 155 KE L+ E F+ R PL + + G++ S G+ W + RR ++ + R FG G++S E Sbjct: 67 KEALIDLGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIE 125 Query: 156 SKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFS 215 ++ EE + + + K P D ++ A N+ IIF +RF Y+D F +++E + Sbjct: 126 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 185 Query: 216 ENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH 275 EN+ + ++ + + N FP I G H +L +N A + + +++ + P+ Sbjct: 186 ENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRD 245 Query: 276 FVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQ 335 F+D +L +M++ K + S F+ ENL+ + +L+ AGTETT+ LR+A+L + +P + + Sbjct: 246 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 336 VQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIP 395 VQ+EI+ ++G N P D+ MPYT+AV+HEV R+ +++P + HA + D R Y IP Sbjct: 306 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 365 Query: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLAR 455 KGTT++T+L SV D K + +PE+F P FLD G F K +PFS G+R C+GE LAR Sbjct: 366 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLAR 425 Query: 456 MEMFLFFTALLQRFHL 471 ME+FLF T +LQ F+L Sbjct: 426 MELFLFLTFILQNFNL 441 >5E0E-A nrPDB Length = 463 Score = 297 bits (760), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 163/437 (37%), Positives = 257/437 (58%), Gaps = 11/437 (2%) Query: 67 RKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLN 126 R+ + YG++F++ LG V+L G + ++E LV Q+E F+ R + + + + G++ Sbjct: 28 RRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIFRGYGVVF 87 Query: 127 SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNA 186 + G W RR ++ + R FG G++S E +I EE + + +G P D L Sbjct: 88 AN-GERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLDPTFLFQCI 146 Query: 187 VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF--GKHQ 244 +NI I+FGERF Y+D F ++ LF ++ L +S S ++ F G L + G H+ Sbjct: 147 TANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS--GFLKYFPGTHR 204 Query: 245 QLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSV 304 Q+ RN + D++ + +EK P P+ F+D YL M++ K++ + F +NL+ SV Sbjct: 205 QISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEFDHQNLVISV 264 Query: 305 GELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAV 364 L AGTET++ LR+ L M YP++ +VQKEID ++G + P+ +D+ KMPYTEAV Sbjct: 265 LSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPYTEAV 324 Query: 365 LHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPER 424 ++E+ RF +++P+G+ H ++D + RGY +PK T V L S D +Y+ P+ F+P+ Sbjct: 325 IYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPDTFNPDH 384 Query: 425 FLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP---DL 481 FLD++G K EA +PFS+G+R CLGE +AR E+FLFFT +LQ F L P + P DL Sbjct: 385 FLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSSP--VAPKDIDL 442 Query: 482 KPR-LGMTLQPQPYLIC 497 P+ G PQ Y IC Sbjct: 443 SPKESGFGKVPQTYQIC 459 >2PG7-A nrPDB Length = 476 Score = 296 bits (759), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 160/462 (34%), Positives = 264/462 (57%), Gaps = 9/462 (1%) Query: 40 PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECL 99 PPGP LPFIGN L ++E + + K S+ YG +F++ LG VVL G+D V+E L Sbjct: 12 PPGPTPLPFIGNYLQL--NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 100 VHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKIL 159 V Q+E F+ R F + K G++ S G RR ++ + R FG G++ E +I Sbjct: 70 VDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDFGVGKRGIEERIQ 128 Query: 160 EETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVE 219 EE F DA+ G D ++ VSN+ + I+FG+RF Y+D +F ++ + + Sbjct: 129 EEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQ 188 Query: 220 LAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDA 279 ++++ LY F + G QQ F+ + DF+++ +E P P+ F+D+ Sbjct: 189 FTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDS 248 Query: 280 YLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKE 339 +L M + + +P++ F +NL+ + +L + GTET + LR+ L + +P ++ +V +E Sbjct: 249 FLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEE 308 Query: 340 IDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTT 399 ID ++G N +P ++D+ KMPY EAV+HE+ RF +++P+ + +D R + +PKGT Sbjct: 309 IDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTE 368 Query: 400 VITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMF 459 V L SV D ++ +P+ F+P+ FL+ G F K +A VPFS+G+R+C GE LARME+F Sbjct: 369 VYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF 428 Query: 460 LFFTALLQRFHL---HFPHELVPDLKPR-LGMTLQPQPYLIC 497 LFFT ++Q F L P ++ D+ P+ +G P+ Y + Sbjct: 429 LFFTTVMQNFRLKSSQSPKDI--DVSPKHVGFATIPRNYTMS 468 >5E58-A nrPDB Length = 493 Score = 295 bits (756), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 161/438 (36%), Positives = 256/438 (58%), Gaps = 10/438 (2%) Query: 65 YMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL 124 +MR + + YG++F++ LG V+L G + ++E LV Q+E F+ R + + + G+ Sbjct: 55 FMRIREK-YGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGDYGM 113 Query: 125 LNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLIT 184 + S G W RR ++ + R FG G++S E +I EE + + ++ +G P D L Sbjct: 114 IFSN-GERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLDPTFLFQ 172 Query: 185 NAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKH 243 +NI I+FGER+ Y+D F +++LF L +S S ++ F ++ P G H Sbjct: 173 CITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKYFP-GAH 231 Query: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303 +Q+ RN + D++ + +EK P P+ F+D YL M++ K++ + F +NL+ S Sbjct: 232 RQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQNLLIS 291 Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363 V L AGTETT+ LR+ L M YP++ +VQKEID ++G + P+ +D+ KMPYT+A Sbjct: 292 VLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPYTDA 351 Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 V+HE+ RF ++ P+G H ++D + RGY +PK T V L S D +Y+ P F+P+ Sbjct: 352 VIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGTFNPD 411 Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH---FPHELVPD 480 FLD++G K EA +PFS+G+R CLGE +AR E+FLFFT +LQ F + P ++ D Sbjct: 412 HFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSSVAPKDI--D 469 Query: 481 LKPR-LGMTLQPQPYLIC 497 L P+ G+ PQ Y I Sbjct: 470 LSPKESGIGKVPQTYQIS 487 >5W0C-A nrPDB Length = 477 Score = 292 bits (747), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 162/437 (37%), Positives = 257/437 (58%), Gaps = 11/437 (2%) Query: 39 FPPGPPGLPFIGNIYSLAA---SSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVV 95 PPGP LP IGNI + S L ++ S+VYG +F+L G VVL+GY+ V Sbjct: 12 LPPGPTPLPVIGNILQIGIKDISKSLTNL-----SKVYGPVFTLYFGLKPIVVLHGYEAV 66 Query: 96 KECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFE 155 KE L+ E F+ R PL + + G++ S G+ W + RR ++ + R FG G++S E Sbjct: 67 KEALIDLGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIE 125 Query: 156 SKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFS 215 ++ EE + + + K P D ++ A N+ IIF +RF Y+D F +++E + Sbjct: 126 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 185 Query: 216 ENVELAASASVFLYNAF-PWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQ 274 EN+++ +S + + N F P I P G H +L +N A + ++ +++ + PQ Sbjct: 186 ENIKILSSPWIQICNNFSPIIDYFP-GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 244 Query: 275 HFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQG 334 F+D +L +M++ K++ S F+ E+L + +L AGTETT+ LR+A+L + +P + Sbjct: 245 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 304 Query: 335 QVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSI 394 +VQ+EI+ ++G N P D+ MPYT+AV+HEV R+ +++P + HA + D R Y I Sbjct: 305 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 364 Query: 395 PKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLA 454 PKGTT++ +L SV D K + +PE+F P FLD G F K + +PFS G+R C+GE LA Sbjct: 365 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 424 Query: 455 RMEMFLFFTALLQRFHL 471 ME+FLF T++LQ F+L Sbjct: 425 GMELFLFLTSILQNFNL 441 >3IBD-A nrPDB Length = 476 Score = 278 bits (711), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 146/403 (36%), Positives = 233/403 (57%), Gaps = 3/403 (0%) Query: 73 YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG 132 YG++F++ LG V+L G + ++E LV ++E F+ R + + + G++ + G Sbjct: 43 YGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNR 101 Query: 133 WVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITN 192 W RR +V + R FG G++S E +I EE + + + KG D L + +NI Sbjct: 102 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 161 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLFRNAA 251 I+FG+RF Y+D +F M+ LF + L +S L+ F ++ P G H+Q+++N Sbjct: 162 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFP-GAHRQVYKNLQ 220 Query: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311 + ++ +EK P P+ +D YL M++ K++ S FS +NL + L AG Sbjct: 221 EINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAG 280 Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371 TETT+ LR+ L M YP++ +V +EI+ ++GP+ P D+ KMPYTEAV++E+ RF Sbjct: 281 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 340 Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431 +++P+G+ H ++ RGY IPK T V L + D Y+ P+ F+P+ FLD++G Sbjct: 341 SDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA 400 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474 K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F + P Sbjct: 401 LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 443 >6B82-A nrPDB Length = 509 Score = 272 bits (696), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 157/487 (32%), Positives = 258/487 (52%), Gaps = 15/487 (3%) Query: 26 GVRQLLKQRRPMG--FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGG 83 G +Q + P G PP P LP IG++ SL + S PH++ + + YG+++SL +G Sbjct: 9 GKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSP-PHIFFQDLQKKYGDLYSLMMGS 67 Query: 84 ISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLN-SRYGRGWVDHRRLAVN 142 +++N + KE L+ + +IFA RP +T+ G + + Y W HR++ Sbjct: 68 HKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHG 127 Query: 143 SFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTY 202 + FG G S E I E + + + D +T AV+N+ + F + Sbjct: 128 ALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKR 187 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD-FLSRLI 261 D +F+ M++ V+ A S L + FPW+ I P K ++ R + D L + Sbjct: 188 GDAEFESMLQYSQGIVDTVAKDS--LVDIFPWLQIFP-NKDLRILRQCISIRDKLLQKKY 244 Query: 262 EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST----FSKENLIFSVGELIIAGTETTTN 317 E+ V + + +DA L +N+ SST ++++++ +VGE+ AG ETTT Sbjct: 245 EEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTT 304 Query: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377 L+W+I ++ P +Q ++Q+E+D +G P D+ +PY EA + EV+R + PL Sbjct: 305 TLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPL 364 Query: 378 GIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL--DSSGYFAKK 435 I H +D+ V Y++ KGT V+ N++S+H DEK W++PE+F P RFL + G Sbjct: 365 LIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPS 424 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQPQPY 494 + +PF G R CLGE LA+ME+FLF +LQRF L P + +PDL+ + G+ LQP+ + Sbjct: 425 GSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKF 484 Query: 495 LICAERR 501 + A+ R Sbjct: 485 KVVAKVR 491 >4R20-A nrPDB Length = 486 Score = 248 bits (633), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 138/442 (31%), Positives = 233/442 (52%), Gaps = 5/442 (1%) Query: 62 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121 PH+ + S YG +F L G T+V++ +V+E L+ + FA RP + +T+ Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 122 GGLLN-SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180 G + + Y W +HRRL +SF FG G ++ + E + ++ +G+ D Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLS 160 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 ++ AV+N+ ++F + D + Q +I+ V+ A L + FPW+ I P Sbjct: 161 VVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGG--LVDIFPWLRIFPN 218 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 ++L ++ L + + + + P P+ +DA L +G + +++++ Sbjct: 219 KDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGG-ADDITEDHV 277 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 + + E AG ETT+ L W I F+ +P +Q +VQ E+D +G + P D+ +P Sbjct: 278 LMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPL 337 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 +AVL EV+R + P+ I H +D + G+S+PKGT V+ N++++H D K+W PE F Sbjct: 338 LDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQF 397 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHEL-VP 479 +PERFL+ SG + + +PF G R C+GE LAR+E+FLF + LQRF P E +P Sbjct: 398 NPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLP 457 Query: 480 DLKPRLGMTLQPQPYLICAERR 501 DL+ R G+ LQP+ Y + R Sbjct: 458 DLQGRFGVVLQPERYTVTVTPR 479 >4R1Z-A nrPDB Length = 439 Score = 240 bits (613), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 138/430 (32%), Positives = 226/430 (52%), Gaps = 12/430 (2%) Query: 81 LGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLN-SRYGRGWVDHRRL 139 +G +++N + KE L+ + +IFA RP +T+ G + + Y W HR++ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 140 AVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGER 199 + FG G S E I E + + + D +T AV+N+ + F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 200 FTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD-FLS 258 + D +F+ M++ V+ A S L + FPW+ I P K + R + D L Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDS--LVDIFPWLQIFP-NKDLTILRQCISIRDKLLQ 177 Query: 259 RLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST----FSKENLIFSVGELIIAGTET 314 + E+ V + + +DA L +N+ SST ++++++ +VG++ AG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 TT VL+W+I ++ P +Q ++Q+E+D +G P D+ +PY EA + EVLR + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS--SGYF 432 PL I H +D+ V Y++ KGT V+ NL+S+H D+K W++PE+F P RFL+ G Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 433 AKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQP 491 + +PF G R CLGE LA+ME+FLF +LQRF L P + +PDL+ + G+ LQP Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQP 417 Query: 492 QPYLICAERR 501 + + + A+ R Sbjct: 418 KKFKVVAKVR 427 >5UYS-A nrPDB Length = 494 Score = 218 bits (554), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 127/447 (28%), Positives = 234/447 (52%), Gaps = 12/447 (2%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 +P LP +G++ L + + + + Q + YG I+S+ +G +TV++ + + KE Sbjct: 9 YPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKK-YGPIYSVRMGTKTTVIVGHHQLAKEV 67 Query: 99 LVHQSEIFADRPCLP-LFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 L+ + + F+ RP + L + G+ + G W HRRLA+ +F F G + E Sbjct: 68 LIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKI 127 Query: 158 ILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217 I +E D + T+ G+ D + AV+N+ +LI F + D + ++I+ ++E Sbjct: 128 ICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL-NVIQNYNEG 186 Query: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277 + + + L + PW+ I P ++L + + D L++++E + + + Sbjct: 187 I-IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 245 Query: 278 DAYL------DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN 331 D + D + G + S S +++ ++G++ AG ETTT+V++W + F+ P Sbjct: 246 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 305 Query: 332 IQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG 391 ++ ++ +EID +G + P+ D+ ++ EA + EVLR + P+ I H + D+ + Sbjct: 306 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 365 Query: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG--YFAKKEALVPFSLGRRHCL 449 +++ KGT VI NL+++H +EK W P+ F PERFL+ +G + + +PF G R C+ Sbjct: 366 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 425 Query: 450 GEHLARMEMFLFFTALLQRFHLHFPHE 476 GE LAR E+FL LLQRF L P + Sbjct: 426 GEILARQELFLIMAWLLQRFDLEVPDD 452 >6DWN-A nrPDB Length = 491 Score = 216 bits (551), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 131/468 (27%), Positives = 234/468 (50%), Gaps = 25/468 (5%) Query: 40 PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECL 99 PPGP G P IG++ +L + PH+ + + SQ YG++ + +G VVL+G D +++ L Sbjct: 13 PPGPWGWPLIGHMLTLGKN---PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 69 Query: 100 VHQSEIFADRPCLPLFMKMTKMGGL-LNSRYGRGWVDHRRLAVNSFRYFGYGQKS----- 153 V Q + F RP L F ++ + + G W RRLA N + F Sbjct: 70 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 129 Query: 154 --FESKILEETKFFNDAIETYKGRPFDFK--QLITNAVSNITNLIIFGERFTYEDTDFQH 209 E + +E + ++ P F + + +V+N+ I FG R+ + + Sbjct: 130 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 189 Query: 210 MIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL--FRN-AAVVYDFLSRLIEKASV 266 ++ L + E+ S N +I IL + + L F++ Y F+ +++++ Sbjct: 190 LVNLNNNFGEVVGSG-----NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 244 Query: 267 NRKPQLPQHFVDAYLDEMDQGKNDPSST--FSKENLIFSVGELIIAGTETTTNVLRWAIL 324 + + D+ ++ + + D ++ S E +I V +L AG +T T + W+++ Sbjct: 245 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 304 Query: 325 FMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATS 384 ++ + P +Q ++Q+E+D ++G + +P D+ +PY EA + E R + VP I H+T+ Sbjct: 305 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 364 Query: 385 EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK--KEALVPFS 442 D ++G+ IPKG V N + ++ D+K W +P F PERFL G K E ++ F Sbjct: 365 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 424 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 +G+R C+GE +AR E+FLF LLQR P + D+ P G+T++ Sbjct: 425 MGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 472 >2HI4-A nrPDB Length = 495 Score = 215 bits (548), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 133/481 (27%), Positives = 229/481 (47%), Gaps = 20/481 (4%) Query: 25 LGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLG 82 + V + L+ R P G PP P G P +G++ +L + PH+ + + SQ YG++ + +G Sbjct: 1 MAVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN---PHLALSRMSQRYGDVLQIRIG 57 Query: 83 GISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYGRGWVDHRRLAV 141 +VL+ D +++ LV Q + F RP L +T L ++ G W RRLA Sbjct: 58 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQ 117 Query: 142 NSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRP--FDFKQLITNAVSNITN 192 N+ F E + +E K ++ P FD + +V+N+ Sbjct: 118 NALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIG 177 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV 252 + FG+ F + +++ E VE A+S + + FP + LP Q+ Sbjct: 178 AMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDF--FPILRYLPNPALQRFKAFNQR 235 Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312 FL + +++ + + A +G + +E ++ V ++ AG Sbjct: 236 FLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGF 295 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 +T T + W+++++ P IQ ++QKE+D ++G +P D+ ++PY EA + E R Sbjct: 296 DTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHS 355 Query: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF 432 + +P I H+T+ D + G+ IPK V N + V+ D + W DP F PERFL + G Sbjct: 356 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 415 Query: 433 AKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 489 K E ++ F +G+R C+GE LA+ E+FLF LLQ+ P + DL P G+T+ Sbjct: 416 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTM 475 Query: 490 Q 490 + Sbjct: 476 K 476 >6IQ5-A nrPDB Length = 463 Score = 208 bits (530), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 131/453 (28%), Positives = 220/453 (48%), Gaps = 24/453 (5%) Query: 63 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 122 H+ + ++ YG++F + LG VVLNG + + LV Q FADRP F ++ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQ----KSFESKILEETKFFNDAI--ETYKGRP 176 + Y W RR A + R F Q + E +L E + + + G Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 177 FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASV-FLYNAFPWI 235 D + L AV+N+ + + FG R++++D +F+ EL S N E + L + PW+ Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFR---ELLSHNEEFGRTVGAGSLVDVMPWL 180 Query: 236 GILP------FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 289 P F + +QL RN + L + + R P+ +DA++ ++ Sbjct: 181 QYFPNPVRTVFREFEQLNRNFSNF--ILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAA 238 Query: 290 DPS----STFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 S + EN+ ++ ++ A +T + L+W +L YP++Q +VQ E+D ++G Sbjct: 239 GDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG 298 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLY 405 + P D+ +PY A L+E +RF + VP+ I HAT+ + V GY IPK T V N + Sbjct: 299 RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQW 358 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKK--EALVPFSLGRRHCLGEHLARMEMFLFFT 463 SV+ D W +PE F P RFLD G K ++ FS+G+R C+GE L++M++FLF + Sbjct: 359 SVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 418 Query: 464 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLI 496 L + + G+T++P+ + + Sbjct: 419 ILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKV 451 >5VBU-A nrPDB Length = 476 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 137/461 (29%), Positives = 219/461 (47%), Gaps = 39/461 (8%) Query: 60 ELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMT 119 +LP +Y+ +Q +G I+ L LG VVLN ++E +V + FA RP PL K+ Sbjct: 25 DLP-IYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP-EPLTYKLV 82 Query: 120 KMG--GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPF 177 L Y W H++L ++ G + S E + + T+ F + + G P Sbjct: 83 SRNYPDLSLGDYSLLWKAHKKLTRSAL-LLGI-RDSMEPVVEQLTQEFCERMRAQPGTPV 140 Query: 178 DFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI 237 ++ + +I + FG++ +D + E ++ + S+ + + P++ Sbjct: 141 AIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-- 197 Query: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH----FVDAYLDEMD---QGKND 290 + F N + L + IEK + QL QH + D MD QG Sbjct: 198 -------RFFPNPGLRR--LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQ 248 Query: 291 PSSTFSKENLI-----FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 PS L+ + +L+I GTETT N L WA++F+ +P IQ ++Q+E+D +G Sbjct: 249 PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELG 308 Query: 346 PNGKPS---WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVIT 402 P S + D+ ++P A + EVLR +VPL + H T+ + + GY IP+GT +I Sbjct: 309 PGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP 368 Query: 403 NLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFF 462 NL H DE W P F P+RFL+ K + F G R CLGE LAR+E+F+ Sbjct: 369 NLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVL 424 Query: 463 TALLQRFHLHFPHELVPDLK--PRLGMTLQPQPYLICAERR 501 T LLQ F L + +P L+ P + L+ QP+ + + R Sbjct: 425 TRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >3QZ1-A nrPDB Length = 496 Score = 167 bits (423), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 127/447 (28%), Positives = 208/447 (46%), Gaps = 29/447 (6%) Query: 64 VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGG 123 +++ +Q G ++ L LG VVLN ++E ++ + FA RP +P + +++ Sbjct: 47 IHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQ 106 Query: 124 LLN-SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQL 182 ++ Y W H++L ++ G + S E + + T+ F + + G P ++ Sbjct: 107 DISLGDYSLLWKAHKKLTRSAL-LLGT-RSSMEPWVDQLTQEFCERMRVQAGAPVTIQKE 164 Query: 183 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 242 + +I + FG + EDT + + ++ S+ + + P++ P Sbjct: 165 FSLLTCSIICYLTFGNK---EDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFP--- 218 Query: 243 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI- 301 + L+R + + ++EK K + D M QG L+ Sbjct: 219 NPGLWRLKQAIENR-DHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLE 277 Query: 302 ----FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS---WDD 354 SV +L I GTETT + L WA+ F+ +P IQ ++Q+E+D +GP S + D Sbjct: 278 GHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKD 337 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 + ++P A + EVLR +VPL + H T+ + + GY IP+G VI NL H DE W Sbjct: 338 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVW 397 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474 P F P+RFL+ A AL F G R CLGE LAR+E+F+ LLQ F L P Sbjct: 398 EQPHEFRPDRFLEPG---ANPSALA-FGCGARVCLGESLARLELFVVLARLLQAFTLLPP 453 Query: 475 -----HELVPDLKPRLGMTLQPQPYLI 496 L PD P G+ L+ QP+ + Sbjct: 454 PVGALPSLQPD--PYCGVNLKVQPFQV 478 >5YLW-A nrPDB Length = 495 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 121/474 (25%), Positives = 204/474 (43%), Gaps = 44/474 (9%) Query: 18 LFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIF 77 L L F L RR PPGP P +GN+ L A+ PH K S+ YG + Sbjct: 7 LAALFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGAN---PHQVFAKLSKRYGPLM 63 Query: 78 SLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM----TKMGGLLNSRYGRGW 133 S+ LG + TV+++ ++ KE L ++F+ R MG L W Sbjct: 64 SIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFL---PVASEW 120 Query: 134 VDHRRLAVNSFRYFGYGQKSFES----------KILEETKFFNDAIETYKGRPFDFKQLI 183 D R++ + +S E+ ++L+ + +D+ GR D ++ Sbjct: 121 RDMRKICKEQM----FSNQSMEASQGLRRQKLQQLLDHVQKCSDS-----GRAVDIREAA 171 Query: 184 TNAVSNITNLIIFGERFTYEDT----DFQHMIELFSENVELAASASVF-LYNAFPWIGIL 238 N+ + +F + T D+ +F+ +IE + V + A F + F G+ Sbjct: 172 FITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGV- 230 Query: 239 PFGKHQQLF--RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFS 296 + +F + A + +L+ +E N F++ +D + Q T Sbjct: 231 --KRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDII-QANEFKLKTHH 287 Query: 297 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356 +L+ +L + G++T T + WA+ + + P+ +++ E+ + G Sbjct: 288 FTHLML---DLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMP 344 Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416 K+PY +AV+ EV+R PL + D V GY IPKGT ++ N Y++ D W D Sbjct: 345 KLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTD 404 Query: 417 PEVFHPERFLDSSGYFAKKE-ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 PE F PERFLD+ F ++ L+PF GRR C G LA + + L+ F Sbjct: 405 PETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 >6DA2-A nrPDB Length = 487 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 125/472 (26%), Positives = 199/472 (42%), Gaps = 25/472 (5%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100 PGP LPF+GNI S + + K+ YG+++ G + + D++K LV Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKK---YGKVWGFYDGQQPVLAITDPDMIKTVLV 75 Query: 101 HQS-EIFADR-PCLPL-FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 + +F +R P P+ FMK ++ W R L +F + Sbjct: 76 KECYSVFTNRRPFGPVGFMK-----SAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIA 130 Query: 158 ILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217 + N E G+P K + ++ FG + + F EN Sbjct: 131 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID----SLNNPQDPFVEN 186 Query: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV----VYDFLSRLIEKASVNRKPQLP 273 + FL F I + PF N V V +FL + +++ +R Sbjct: 187 TKKLLRFD-FLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 245 Query: 274 QHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYP 330 +H VD +D + + + S L+ I AG ETT++VL + + +A +P Sbjct: 246 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 305 Query: 331 NIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVR 390 ++Q ++Q+EID ++ P++D +M Y + V++E LR I + + +D + Sbjct: 306 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEIN 364 Query: 391 GYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLG 450 G IPKG V+ Y++H D KYW +PE F PERF + PF G R+C+G Sbjct: 365 GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIG 424 Query: 451 EHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501 A M M L +LQ F E LK LG LQP+ P ++ E R Sbjct: 425 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >5VEU-A nrPDB Length = 480 Score = 124 bits (311), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 122/480 (25%), Positives = 211/480 (43%), Gaps = 42/480 (8%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100 PGP LP +GN+ S K+ YG+++ G + + + DV++ LV Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKK---YGKMWGTYEGQLPVLAITDPDVIRTVLV 74 Query: 101 HQS-EIFADRPCL-PL-FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 + +F +R L P+ FMK ++ W R L +F G ++ F Sbjct: 75 KECYSVFTNRRSLGPVGFMK-----SAISLAEDEEWKRIRSLLSPTFTS-GKLKEMFP-- 126 Query: 158 ILEETKFFNDAI------ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211 I+ + + D + E KG+P K + ++ FG + + Sbjct: 127 IIAQ---YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFV 183 Query: 212 ELFSENVELAASASVFLYNA-FPWIGILPFGKHQQLFRNAAVVYDFLSRLI---EKASVN 267 E + ++ +FL FP++ + + LF + +FLS+ + +K+ +N Sbjct: 184 ESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLN 241 Query: 268 RKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327 K + F+ +D + + + S L I AG ETT++VL + + +A Sbjct: 242 DKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 301 Query: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387 +P++Q ++QKEID ++ P++D +M Y + V++E LR + + + +D Sbjct: 302 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDV 360 Query: 388 VVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL-----VPFS 442 + G IPKG+ V+ Y++H D KYW +PE F PERF KK+++ PF Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF------SKKKDSIDPYIYTPFG 414 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501 G R+C+G A M M L +LQ F E LK LQP+ P ++ + R Sbjct: 415 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 474 >6C94-A nrPDB Length = 497 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 87/354 (24%), Positives = 151/354 (42%), Gaps = 24/354 (6%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPFDFKQLITNAV 187 G W HR+L F Y K + + + T+ + E +G+ FD + + Sbjct: 109 GPKWFQHRKLLTPGFHYDVL--KPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMA 166 Query: 188 SNITNLIIFGER---FTYEDTDF----QHMIELFSENVELAASASVFLYNAFPWIGILPF 240 + FG+ + D+ + + L + ++ + F+Y W+ P Sbjct: 167 LDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIY----WL--TPH 220 Query: 241 GKHQQLFRNAAVVYDFLSRLIE--KASVNRKPQLPQHFVDAYLDEMD---QGKNDPSSTF 295 G+ + R +D R+I KA++ + + + +LD +D + + Sbjct: 221 GR--RFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQL 278 Query: 296 SKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK 355 S +L V + G +TTT+ + W + MALYP Q + ++E+ I+G W+D Sbjct: 279 SDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDL 338 Query: 356 CKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWR 415 KM Y + E R VP + + V G S+P G+ + ++Y++H + W Sbjct: 339 AKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWP 398 Query: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DPEVF P RF + A +PFS G R+C+G+ A EM + L RF Sbjct: 399 DPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRF 452 >2VE3-A nrPDB Length = 444 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 122/461 (26%), Positives = 198/461 (42%), Gaps = 43/461 (9%) Query: 37 MGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVK 96 + PPG GLP++G + + + +K+ Q +G IF L G + + ++G + Sbjct: 11 LPIPPGDFGLPWLGETLNFLNDGD----FGKKRQQQFGPIFKTRLFGKNVIFISGALANR 66 Query: 97 ECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFES 156 + E F + PL ++ L ++ G R++ +F ++ +S Sbjct: 67 FLFTKEQETF--QATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFL-----PRTLDS 119 Query: 157 KILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSE 216 + + +E + G+ N V L R T++ M E S+ Sbjct: 120 YLPKMDGIVQGYLEQW-GK--------ANEVIWYPQL----RRMTFDVAATLFMGEKVSQ 166 Query: 217 NVELAASASVFLYNAFPWIGILP---FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLP 273 N +L ++ F LP FGK Q R A++ L ++I+ + Q P Sbjct: 167 NPQLFPWFETYIQGLFSLPIPLPNTLFGKSQ---RARALLLAELEKIIKA-----RQQQP 218 Query: 274 QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQ 333 DA L + ++D + S L + L+ AG ET T+ L L + + +I+ Sbjct: 219 PSEEDA-LGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIR 277 Query: 334 GQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYS 393 +V++E + + + + + + KMPY + VL EVLR V G F +D +G+ Sbjct: 278 ERVRQEQNKLQL-SQELTAETLKKMPYLDQVLQEVLRLIPPVG-GGFRELIQDCQFQGFH 335 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL-DSSGYFAKKEALVPFSLGRRHCLGEH 452 PKG V + H D + DPE F PERF D S A VPF G R CLG+ Sbjct: 336 FPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKE 395 Query: 453 LARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQP 493 AR+EM LF T L+Q+F L+P L +T P+P Sbjct: 396 FARLEMKLFATRLIQQFDW----TLLPGQNLELVVTPSPRP 432 >3K9V-A nrPDB Length = 482 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 98/457 (21%), Positives = 186/457 (40%), Gaps = 56/457 (12%) Query: 41 PGPPGLPFIGNIYSLAASSELP--HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PGP P +G++ + L H + + + YG+IF + LG +V L G + E Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR----LAVNSFRYFGYGQKSF 154 L R L + + + DHR L + + + + +F Sbjct: 86 LYRTESAHPQR---------------LEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAF 130 Query: 155 ESKILEETKFFN----------------DAIETYKGRPFDFKQLITNAVSNITNLIIFGE 198 + K+++ + D + +GR D + L+++ + Sbjct: 131 QKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEK 190 Query: 199 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL----FRNAAVVY 254 RF + + F +A + + F + + P H++L ++ + + Sbjct: 191 RFGLLQKETEEEALTF-------ITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW 243 Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314 D + + ++ NR + Q +L ++ Q + SK+ L +V EL +A ET Sbjct: 244 DTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVET 298 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 T N L W + ++ P Q ++ +E+ ++ N P +D MPY +A L E +R Sbjct: 299 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 358 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 VP + V+ Y++PKGT + N + E + D F PER+L Sbjct: 359 VPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-N 416 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471 A +PF +G+R C+G LA +++ L ++Q++ + Sbjct: 417 PFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 453 >3MDV-A nrPDB Length = 456 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 118/250 (47%), Gaps = 22/250 (8%) Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314 D++ R + ++ R ++P + L + ++D E L+ + IAG ET Sbjct: 208 DWVQR--RREALKRGEEVPADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHET 258 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 + N L + ++ ++ P I ++Q E+D ++G ++D ++ Y VL E LR Sbjct: 259 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPP 318 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 G F E+ ++ G +P T ++ + Y + + Y+ DP F+P+RF G Sbjct: 319 A-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKP 375 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGM----TLQ 490 + PFSLG R C+G+ A+ME+ + LLQR LVP R G+ TL+ Sbjct: 376 RFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR----LVPG--QRFGLQEQATLK 429 Query: 491 PQPYLICAER 500 P ++C R Sbjct: 430 PLDPVLCTLR 439 >4KPA-A nrPDB Length = 494 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/252 (30%), Positives = 126/252 (50%), Gaps = 19/252 (7%) Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS--TFSKENLIFSVGELIIAGTET 314 ++ L++K +RK Q D L M GK DP + EN+ + + +IAG ET Sbjct: 236 MNDLVDKIIADRKASGEQS--DDLLTHMLNGK-DPETGEPLDDENIRYQIITFLIAGHET 292 Query: 315 TTNVLRWAILFMALYPNI-QGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 T+ +L +A+ F+ P++ Q ++ +++ P PS+ ++ Y VL+E LR Sbjct: 293 TSGLLSFALYFLVKNPHVLQKAAEEAARVLVDP--VPSYKQVKQLKYVGMVLNEALRLWP 350 Query: 374 IVPLGIFHATSEDAVVRG-YSIPKGTTVITNLYSVHFDEKYWRDP-EVFHPERFLDSSGY 431 P +A ED V+ G Y + KG ++ + +H D+ W D E F PERF + S Sbjct: 351 TAPAFSLYA-KEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAI 409 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL--HFPHELVPDLKPRLGMTL 489 + A PF G+R C+G+ A E L +L+ F H +EL D+K L TL Sbjct: 410 --PQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYEL--DIKETL--TL 463 Query: 490 QPQPYLICAERR 501 +P+ +++ A+ + Sbjct: 464 KPEGFVVKAKSK 475 >3EL3-A nrPDB Length = 467 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 116/238 (48%), Gaps = 13/238 (5%) Query: 260 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVL 319 + E+ + +KP D L + + K+D ++ + V ++ G+ET + + Sbjct: 231 IAERRASGQKP-------DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTI 283 Query: 320 RWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 W + +A +P +++ E++ + G G+P +++D K+ +T V+ E +R V + Sbjct: 284 MWLLQALADHPEHADRIRDEVEAVTG--GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL 341 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438 A +E + + GY IP G +I + Y++ D K + D F P+R+L K A+ Sbjct: 342 TRRAVAE-SELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAM 400 Query: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLI 496 PFS G+R C +H + ++ L AL ++ F + R+G+TL+P L+ Sbjct: 401 KPFSAGKRKCPSDHFSMAQLTLITAALATKY--RFEQVAGSNDAVRVGITLRPHDLLV 456 >3S79-A nrPDB Length = 503 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 52/177 (29%), Positives = 90/177 (50%), Gaps = 7/177 (3%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 ++EN+ + E++IA +T + L + + +A +PN++ + KEI ++G DD Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDD 349 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 K+ E ++E +R+ +V L + ED V+ GY + KGT +I N+ +H E ++ Sbjct: 350 IQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FF 407 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471 P F E F + Y PF G R C G+++A + M LL+RFH+ Sbjct: 408 PKPNEFTLENFAKNVPY----RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460 >6AYB-A nrPDB Length = 466 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 103/459 (22%), Positives = 180/459 (39%), Gaps = 63/459 (13%) Query: 39 FPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKE 97 PP P L P++G+ S A + P ++ S+ YG++F+ + G LN ++ Sbjct: 11 LPPRVPNLIPYVGSFVSFAKN---PVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDT 67 Query: 98 CLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 + R FM+ +G G V Y S E + Sbjct: 68 FFKATDNELSLRDVY-RFMRPV---------FGTGVV--------------YDADSTE-R 102 Query: 158 ILEETKFFNDAIETYKGRPFD--FKQLITNAVSNI------------TNLIIF-GERFTY 202 ++E+ KF + + T + R F F+ I + V + +LIIF R Sbjct: 103 MMEQVKFVSSGLTTARFRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLL 162 Query: 203 EDTDFQHMIEL----FSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 258 D Q++ E +++ S F Y + P + R A V + Sbjct: 163 GDEVRQYLSEKNLGKLYHDIDDGISPLSFFYPSLP-------APKRDKARKA--VGEIFQ 213 Query: 259 RLIEKASVNRKPQLPQHFVD-AYLDEMDQGKNDPSSTFSKENLIFSVGELI---IAGTET 314 L++K K P+ +D + +D +D + + +G LI AG T Sbjct: 214 ELLDKRREEHKKH-PERLLDESKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHT 272 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 ++ W ++ + + +V+KE + IMG + +D KM Y EA + E LR Sbjct: 273 SSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPP 332 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 + + I + Y IPKG ++ + + +P+VF PER + + Sbjct: 333 L-IMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKF 391 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF 473 K VPF GR C+GE+ A +++ + LL+ F + + Sbjct: 392 KYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEY 430 >6M7X-A nrPDB Length = 484 Score = 74.7 bits (182), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 99/410 (24%), Positives = 165/410 (40%), Gaps = 44/410 (10%) Query: 63 HVYMRKQSQVYGEIFSLDLGGISTV-VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121 H+ + + Q G IF DLGG V V+ DV E L + R L ++ + Sbjct: 42 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV--EKLQQVDSLHPHRMSLEPWVAYRQH 99 Query: 122 GG------LLNS---RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172 G LLN R+ R ++ L+ N+ + F + + K ++ Sbjct: 100 RGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK--KKVLQNA 157 Query: 173 KGR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAAS 223 +G D + I + +NL +FGER + +F H +E +F V+L Sbjct: 158 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL--- 214 Query: 224 ASVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD 282 +F+ + W + +H F ++ + I+K PQ + + Sbjct: 215 --MFMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAE 269 Query: 283 EMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDL 342 + + P + K N + EL +TT L + +A PN+Q +++E Sbjct: 270 LLLNAELSPDAI--KANSM----ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 323 Query: 343 IMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKGTTV 400 + ++P A L E LR + P+G+F S D V++ Y IP GT V Sbjct: 324 AAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLV 380 Query: 401 ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLG 450 LYS+ + + PE ++P+R+LD G + VPF G R CLG Sbjct: 381 RVFLYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLG 429 >4ZGX-A nrPDB Length = 489 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/285 (24%), Positives = 120/285 (42%), Gaps = 29/285 (10%) Query: 177 FDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAASASVFL 228 D + I + +NL +FGER + +F H +E +F V+L +F+ Sbjct: 163 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL-----MFM 217 Query: 229 YNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 287 + WI + +H F ++ + I+K PQH+ + + + Sbjct: 218 PRSLSRWISPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA 274 Query: 288 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 + S E + + EL +TT L + +A P++Q +++E Sbjct: 275 E------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 328 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKGTTVITNLY 405 + ++P A L E LR + P+G+F S D V++ Y IP GT V LY Sbjct: 329 SEHPQKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 385 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLG 450 S+ + + PE ++P+R+LD G + VPF G R CLG Sbjct: 386 SLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLG 429 >3N9Z-A nrPDB Length = 487 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 10/204 (4%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 S S E++ +V E++ G +TT+ L+W + MA +Q ++ E+ + + Sbjct: 268 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQ 324 Query: 352 WDDKCKM---PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 D + P +A + E LR I + + D V+R Y IP T V +Y++ Sbjct: 325 GDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 383 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 + ++ DPE F P R+L L F G R CLG +A +EM +F +L+ Sbjct: 384 REPTFFFDPENFDPTRWLSKDKNITYFRNL-GFGWGVRQCLGRRIAELEMTIFLINMLEN 442 Query: 469 FHLHFPHELVPDLKPRLGMTLQPQ 492 F + H + D+ + L P+ Sbjct: 443 FRVEIQH--LSDVGTTFNLILMPE 464 >5IT1-A nrPDB Length = 399 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 85/359 (23%), Positives = 131/359 (36%), Gaps = 77/359 (21%) Query: 123 GLLNSRYGRG---W------VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYK 173 G++ + GRG W D R+L F ++ I DAIE + Sbjct: 76 GVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFTV--RRMQALRPNIQRIVDEHLDAIEA-R 132 Query: 174 GRPFDFKQLITNAVSNITNLIIFG---ERFTYEDTDFQHMIELFSENVELAASASVFLYN 230 G P D + N V ++ +FG ER +FQ + E + AA+ Sbjct: 133 GGPVDLVKTFANPVPSMVISDLFGVPAER----RAEFQEIAEAMMRVDQDAAATEA---- 184 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 A +G L + Q+ R A D +S LI D Sbjct: 185 AGMRLGGLLYQLVQE--RRANPGDDLISALITT-------------------------ED 217 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 P L+ + G L+IA +TT ++ + P+ +QK+ LI Sbjct: 218 PDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKDPSLIGN----- 272 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 + E+LR+ I G ++D + G I KG V+T+L S FD Sbjct: 273 -------------AVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFD 319 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + DPE F R + + F G C+G+ LAR+E+ + F L +RF Sbjct: 320 PAFVEDPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >3MZS-A nrPDB Length = 486 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 14/199 (7%) Query: 298 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD-DKC 356 E++ ++ E++ G TT+ L+W + MA N+Q +++E+ N + + D Sbjct: 275 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV-----LNARRQAEGDIS 329 Query: 357 KM----PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEK 412 KM P +A + E LR + + + + D V++ Y IP T V +Y++ D Sbjct: 330 KMLQMVPLLKASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 388 Query: 413 YWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 472 ++ P+ F P R+L L F G R C+G +A +EM LF +L+ F + Sbjct: 389 FFSSPDKFDPTRWLSKDKDLIHFRNL-GFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 447 Query: 473 FPHELVPDLKPRLGMTLQP 491 H + D+ + L P Sbjct: 448 MQH--IGDVDTIFNLILTP 464 >5NWS-A nrPDB Length = 435 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 105/251 (41%), Gaps = 31/251 (12%) Query: 219 ELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD 278 EL + L W G L + ++L + V+ D+ RLIE+ R+ L D Sbjct: 184 ELVGIPATDLERWREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQ----RRAAL----TD 235 Query: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338 L E+ + ++D S + + L++AG ET+ +++ + +P ++K Sbjct: 236 DLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRK 295 Query: 339 EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGT 398 D +P +HE++R+C V + +ED + G + +G Sbjct: 296 ---------------DPALLPR---AVHELMRWCGSVHVARLRYATEDLELAGTPVARGD 337 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 V L S +FD +++ DP+ R + + E V F G +CLG LAR E Sbjct: 338 AVQLVLVSANFDPRHYSDPDRLDITRHQE-----GQAENHVGFGHGIHYCLGATLARQEG 392 Query: 459 FLFFTALLQRF 469 + LL+ + Sbjct: 393 EVALARLLETY 403 >4OQS-A nrPDB Length = 433 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 90/376 (23%), Positives = 147/376 (39%), Gaps = 83/376 (22%) Query: 106 FADRP--CLPLFMKMTKMGGLLNSRYGRGW---------VDHRRLAVNSFRYFGYGQKSF 154 F++RP P+F + + GG + GW +RR+ ++ F K Sbjct: 65 FSNRPEHKHPVFSVIPRPGGATKA-PAPGWFINMDAPEHTRYRRMLISQFTVRRI--KEL 121 Query: 155 ESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELF 214 E +I++ T+ DA+ G P D Q V ++ + G +Y D F F Sbjct: 122 EPRIVQITEDHLDAM-AKAGPPVDLVQAFALPVPSLVICELLG--VSYADHAF------F 172 Query: 215 SENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQ 274 E + AS K Q A L+R I + ++ Sbjct: 173 QEQTTIMASVD----------------KTQDEVTTA---LGKLTRYIAELVATKRLSPKD 213 Query: 275 HFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQG 334 + + + + D + E L L++AG ETT N+L + +P Sbjct: 214 DLLGSLITDTD---------LTDEELTNIALLLLVAGHETTANMLGLGTFALLQHP---- 260 Query: 335 QVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFH-ATSEDAVVRGYS 393 ++I + P+ + E+LR+ +IV LG + A ED + G Sbjct: 261 ---EQIAALDSPDA----------------VEELLRYLSIVHLGTPNRAALEDVELEGQM 301 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHL 453 I KG TV L +V+ D K + +P++ +R +D+ + A F G CLG+ L Sbjct: 302 IRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-VDARKHAA-------FGGGIHQCLGQQL 353 Query: 454 ARMEMFLFFTALLQRF 469 AR+EM + FT L RF Sbjct: 354 ARVEMRIGFTRLFARF 369 >3TYW-A nrPDB Length = 417 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 77/175 (44%), Gaps = 27/175 (15%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + E L+ ++G I AG ETTT+++ + L + P + +++K+ DL Sbjct: 234 VTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKDPDL------------ 281 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 MP L VL + +PL + +ED + G ++P VI L + D + + Sbjct: 282 ---MPAAVDELLRVLSVADSIPLRV---AAEDIELSGRTVPADDGVIALLAGANHDPEQF 335 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DPE + V F G C+G+HLAR+E+ + LL+R Sbjct: 336 DDPERVD---------FHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 >5YSW-A nrPDB Length = 441 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/193 (28%), Positives = 87/193 (45%), Gaps = 33/193 (17%) Query: 290 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 349 DP+ + + LI L+IAG +TT ++L I + P ++ Sbjct: 259 DPA--LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLR------------ 304 Query: 350 PSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHF 409 DD ++ +AV E+LR+ ++V GIF ED G IP G+TV+ ++ + + Sbjct: 305 ---DDPSRI--ADAV-EELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNR 358 Query: 410 DEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D ++W DP++ + + F G CLG+ LARMEM + LL+R Sbjct: 359 DARHWPDPDL----------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRL 408 Query: 470 ---HLHFPHELVP 479 L P E VP Sbjct: 409 PNVRLAVPPEEVP 421 >3JUS-A nrPDB Length = 461 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 94/456 (20%), Positives = 175/456 (38%), Gaps = 48/456 (10%) Query: 30 LLKQRRPMGFPPGP---PGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGIST 86 + K+ P G P +PF+G+ + S P ++ + YG +FS + G + Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFGKS---PIEFLENAYEKYGPVFSFTMVGKTF 57 Query: 87 VVLNGYDVVKECLVHQSEIFA-----DRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAV 141 L G D ++E R P+F K G+ +++ +++ Sbjct: 58 TYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGK-----GVAYDVPNPVFLEQKKMLK 112 Query: 142 NSFRYFGYGQKSFESKILEETK-FFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERF 200 + + Q S I +ETK +F E+ + N ++ LII Sbjct: 113 SGLNIAHFKQHV--SIIEKETKEYFESWGESGE----------KNVFEALSELIILTASH 160 Query: 201 TYEDTDFQHMIELFSENVELAASASVFLYNAFP---WI--GILPFGKHQQLFRNAAVVYD 255 H E+ S+ E A L F W+ G LP ++ R + D Sbjct: 161 CL------HGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKD 214 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + I+K + Q +D L + + + + + L++AG T+ Sbjct: 215 IFYKAIQKRRQS------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTS 268 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNI 374 + W F+A +Q + E + G N P ++D + + + E LR Sbjct: 269 STTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPP 328 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 + + + A + V GY+IP G V + + W + F+P+R+L + + Sbjct: 329 IMIMMRMARTPQTVA-GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE 387 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 K A VPF GR C+GE+ A +++ ++ +L+ + Sbjct: 388 KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 423 >2Z36-A nrPDB Length = 413 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 79/176 (44%), Gaps = 30/176 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+ AG ETT N++ ++ + +P +++ ++ G+ T + Sbjct: 242 LLTAGHETTANMISLGVVGLLSHP-------EQLTVVKANPGR-----------TPMAVE 283 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E+LR+ I +ED + G SI G VI ++ S ++D ++DP V ER Sbjct: 284 ELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER-- 341 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELVP 479 + + A F G CLG++LARME+ + F L +R L P E VP Sbjct: 342 GARHHLA-------FGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVP 390 >4OQR-A nrPDB Length = 457 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 32/164 (19%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L++AG ETT N+L + +P ++I + P+ + Sbjct: 276 LLVAGHETTANMLGLGTFALLQHP-------EQIANLDSPDA----------------VE 312 Query: 367 EVLRFCNIVPLGIFH-ATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E+LR+ +IV LG + A ED + G I KG TV L +V+ D K + +P++ +R Sbjct: 313 ELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR- 371 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 +D+ + A F G CLG+ LAR+EM + FT L RF Sbjct: 372 VDARKHAA-------FGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >1WIY-A nrPDB Length = 389 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 89/209 (42%), Gaps = 29/209 (13%) Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 + P S +E + L++AG ET + L W+ L ++ P+ Q +V + + Sbjct: 200 HPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEE------- 252 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYS-IPKGTTVITNLYSV 407 A E LR P I E ++ G +P+GTT++ + Y Sbjct: 253 -----------AALAAFQEALRLYP--PAWILTRRLERPLLLGEDRLPQGTTLVLSPYVT 299 Query: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 Y+ + E F PERFL G + + PF LG+R CLG A +E + A + Sbjct: 300 Q--RLYFPEGEAFQPERFLAERGTPSGR--YFPFGLGQRLCLGRDFALLEGPIVLRAFFR 355 Query: 468 RFHLH---FPHELVP-DLKPRLGMTLQPQ 492 RF L FP L L+P G+ +P+ Sbjct: 356 RFRLDPLPFPRVLAQVTLRPEGGLPARPR 384 >3MGX-A nrPDB Length = 415 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 76/175 (43%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + ++++ + ++I G ETT + + A+ +A P + ++ +G D Sbjct: 239 LTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALR---------DGSADVD- 288 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 V+ EVLR+ + + + T+ D + G +P GT V+ L + + D + Sbjct: 289 --------TVVEEVLRWTSPA-MHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEF 339 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DP+ F P R K + F G HCLG LAR+E+ + L +R Sbjct: 340 DDPDTFLPGR---------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERV 385 >5DQN-A nrPDB Length = 426 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 49/229 (21%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + ++ E+ +VN + ++A +D S + F V L +AG ETT Sbjct: 206 YAMKMAEERAVNPTEDIVTKLIEADID---------GEKLSDDEFGFFVVMLAVAGNETT 256 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 N + ++ A P+ +KE +P E E++R+ Sbjct: 257 RNSITHGMIAFAQNPDQWELYKKE---------RP-----------ETAADEIVRWA--T 294 Query: 376 PLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 P+ F T+ ED + G I KG V+ + S +FDE+ + DP F+ R + F Sbjct: 295 PVSAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHVGFG- 353 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483 G +C+G +LARM + L F A+ +PDLKP Sbjct: 354 -------GTGAHYCIGANLARMTINLIFNAIADN---------MPDLKP 386 >6GMF-A nrPDB Length = 397 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 97/235 (41%), Gaps = 37/235 (15%) Query: 235 IGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST 294 + ++ G QL R+ Y + S ++E+ + L + A E+D K Sbjct: 167 LALVRVGNAAQLERSTQEFYAYFSEVLEERRREPREDLISQLLAA---EVDGEKLTAGEV 223 Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 S N L+IAG ETTT+++ A++ + +P Q ++ L+ Sbjct: 224 LSFAN------TLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV----------- 266 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 AV+ EVLR+ + IF T D + IP + V+ L S + DE + Sbjct: 267 -------PAVVEEVLRYESPAQC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRF 318 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DP+ F R D+ G+ A F L C+G LAR+E + LL R Sbjct: 319 PDPDRFDIHR--DTKGHLA-------FGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >4YZR-A nrPDB Length = 405 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 92/215 (42%), Gaps = 36/215 (16%) Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314 D++++LI + K L V A + S S++ L + L++AG ET Sbjct: 195 DYIAKLIHDRRIKPKDDLISKLVHA---------EENGSKLSEKELYSMLFLLVVAGLET 245 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 T N+L L + + +++++ ++I + E+LR+ + Sbjct: 246 TVNLLGSGTLALLQHKKECEKLKQQPEMIA------------------TAVEELLRYTSP 287 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 V + ED +G+SI +G + + S + D ++ +PE+ + R + Sbjct: 288 VVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNRH----- 342 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + F G CLG LAR+E + F ALL+RF Sbjct: 343 ----ISFGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >3P3Z-A nrPDB Length = 416 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 85/218 (38%), Gaps = 38/218 (17%) Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312 ++D+L IEK V L V A+ D L V +++AG Sbjct: 206 MFDYLVAAIEKRKVEPGDDLTSDIVRAFHD----------GVLDDYELRTLVATVLVAGY 255 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 ETT + L A+ A +P+ ++++ +L + EVLR+ Sbjct: 256 ETTNHQLALAMYDFAQHPDQWMKIKENPEL------------------APQAVEEVLRWS 297 Query: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF 432 +P+ +ED V G IP GT V + H RDP VF D + Sbjct: 298 PTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAH------RDPRVFADADRFDIT--- 348 Query: 433 AKKEA-LVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 K+EA + F G CLG LAR+E+ AL R Sbjct: 349 VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRL 386 >2VZM-A nrPDB Length = 436 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 35/213 (16%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 +LSRLI+ +++ Q + + A + D+ S + E L+ L++AG ETT Sbjct: 217 YLSRLID----SKRGQDGEDLLSALVRTSDED----GSRLTSEELLGMAHILLVAGHETT 268 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 N++ + + +P+ ++ ++ L+ G + E+LR+ V Sbjct: 269 VNLIANGMYALLSHPDQLAALRADMTLLDG------------------AVEEMLRYEGPV 310 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 + E + G IP G TV+ L H + + DP F R D++G+ A Sbjct: 311 ESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR--DTAGHLA-- 366 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 F G C+G LAR+E + ALL+R Sbjct: 367 -----FGHGIHFCIGAPLARLEARIAVRALLER 394 >4WMZ-A nrPDB Length = 539 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 101/224 (45%), Gaps = 26/224 (11%) Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV-QKEIDLIMGPNGKPSWDDKCK 357 NL+ V ++ G T+ W +L +A P++Q ++ ++++ ++ G + ++D + Sbjct: 306 NLLIGV---LMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQE 362 Query: 358 MPYTEAVLHEVLRFCNIVPL-GIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYW 414 MP + E LR + PL +F +D V Y IP G V+ + H ++Y+ Sbjct: 363 MPLLNQTIKETLRMHH--PLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYF 420 Query: 415 RDPEVFHPERFL-DSSGYFAKKEAL---------------VPFSLGRRHCLGEHLARMEM 458 + F+ R+ DS+ ++ E + +PF GR C+GEH A ++ Sbjct: 421 PNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQL 480 Query: 459 FLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQPQPYLICAERR 501 + + ++ H+P + VP +TL P I E+R Sbjct: 481 GVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKR 524 >5L94-A nrPDB Length = 410 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 31/185 (16%) Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 Q K + +E + FS+ L+IAG ETTTN++ I + ++++E +L+ Sbjct: 219 QAKEEGKQLTDEEIVGFSIL-LLIAGNETTTNLISNTIYCLMEDKASFERLKREKELL-- 275 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA-TSEDAVVRGYSIPKGTTVITNL 404 P+G + EVLR+ + P+ H ED + G + G V+ + Sbjct: 276 PSG----------------IEEVLRYRS--PVQALHRIVKEDVTLAGKKLKAGEHVVPWM 317 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464 S H D +Y+ DPEVF +R K + F G CLG LAR+E + Sbjct: 318 GSAHRDAEYFEDPEVFKIDR---------KPNVHMAFGRGIHFCLGAPLARIEAKIMLAE 368 Query: 465 LLQRF 469 L+ R+ Sbjct: 369 LIDRY 373 >5FSA-A nrPDB Length = 490 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 91/222 (40%), Gaps = 29/222 (13%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP----SWDDKCKMPYTE 362 +++ G T+ + W +L + P++Q + +E+ ++ G +++D K+P Sbjct: 262 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 321 Query: 363 AVLHEVLRFCNIVPL-GIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 + E LR +PL IF + + Y +PKG V+ + H E+Y+ +PE Sbjct: 322 NTIKETLRMH--MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED 379 Query: 420 FHPERF------LDSSGYFAKKEA--------------LVPFSLGRRHCLGEHLARMEMF 459 F P R+ +S + + E +PF GR C+GE A +++ Sbjct: 380 FDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG 439 Query: 460 LFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 T + VPD + L +P I E+R Sbjct: 440 TILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKR 481 >3ABB-A nrPDB Length = 408 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 90/217 (41%), Gaps = 35/217 (16%) Query: 266 VNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILF 325 V RK P+ D LDE+ + + ++ L++AG ETT N + L Sbjct: 203 VGRKQAEPE---DGLLDEL-IARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALT 258 Query: 326 MALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSE 385 + +P ++ID+++ G S V+ E+LRF ++ I E Sbjct: 259 LIQHP-------EQIDVLLRDPGAVS-----------GVVEELLRFTSVSD-HIVRMAKE 299 Query: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR 445 D V G +I G V+ ++ ++ D K + +P++F R V F G Sbjct: 300 DIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR---------NARHHVGFGHGI 350 Query: 446 RHCLGEHLARMEMFLFFTALLQR---FHLHFPHELVP 479 CLG++LAR E+ + L R L P + VP Sbjct: 351 HQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVP 387 >3A50-A nrPDB Length = 411 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 92/212 (43%), Gaps = 37/212 (17%) Query: 248 RNAAV--VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVG 305 +NAA+ ++ +LS L+E RK P DA L + + S+E L+ Sbjct: 180 KNAAMGKLHGYLSDLLE-----RKRTEPD---DALLSSLLAVSDMDGDRLSQEELVAMAM 231 Query: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365 L+IAG ETT N++ +L + +P+ + + ++ LI + + Sbjct: 232 LLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLI------------------SSAV 273 Query: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E LRF + V T+ED G +IP G V+ L + + D + +P+ R Sbjct: 274 EEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR- 332 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 D+SG V F G CLG LAR+E Sbjct: 333 -DASGG-------VFFGHGIHFCLGAQLARLE 356 >5OFQ-A nrPDB Length = 409 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 99/231 (42%), Gaps = 40/231 (17%) Query: 240 FGKHQQLFRNAAVVY--DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSK 297 F K Q RN V++ + +I + N++ L ++A +D ++ Sbjct: 179 FAKMMQK-RNEGVIFLQGYFKEIIAERQQNKQEDLISLLLEAEID---------GEHLTE 228 Query: 298 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCK 357 E ++ L++AG ETTTN++ + +M ++Q +V+++I L+ PN Sbjct: 229 EEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLV--PN---------- 276 Query: 358 MPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 417 ++ E LR+ + I +ED + I +G VI+ S + D + P Sbjct: 277 ------LVEETLRYYPPIQ-AIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWP 329 Query: 418 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 + F R K V F G CLG LARME + FT LL++ Sbjct: 330 DTFVVHR---------KTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEK 371 >1Q5D-A nrPDB Length = 419 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/184 (29%), Positives = 78/184 (42%), Gaps = 28/184 (15%) Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 Q + D S +KE L+ VG +I AGT+TT ++ +A+L + P V+ E L+ Sbjct: 231 QAEADGSRLSTKE-LVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPGLMRN 289 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLY 405 L EVLRF NI+ +G +D G SI KG V + Sbjct: 290 ------------------ALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIP 331 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465 S D + P+VF R D+S A + G C G LAR+E + + Sbjct: 332 SALRDGTVFSRPDVFDVRR--DTSASLA-------YGRGPHVCPGVSLARLEAEIAVGTI 382 Query: 466 LQRF 469 +RF Sbjct: 383 FRRF 386 >4GGV-A nrPDB Length = 418 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 90/416 (21%), Positives = 161/416 (38%), Gaps = 77/416 (18%) Query: 60 ELPHVYMRKQS--QVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMK 117 E P V+ Q VYG ++D +LN +D L H + D P L Sbjct: 44 ESPVVFDETQGVWNVYGYPEAMD-------ILNDHDTFTSDLAHLLPVSVDAPLLE--GD 94 Query: 118 MTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPF 177 M++M + +Y R+L +F E+++ + T+ DA++ G+P Sbjct: 95 MSQMDPPRHRKY-------RQLVSRAFTPRLVAD--METRVADITRELLDAVD---GKP- 141 Query: 178 DFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI 237 + I ++ +I+ E D + + + +++++ S FL + Sbjct: 142 --EIEIAADLAYPLPVIVIAELLGVPAGD-RDLFKKWADDIIEGFSGFSFLDTS------ 192 Query: 238 LPFGKHQQLFRNAA----VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS 293 G+ +Q R+A + D+++ + + + L H V A +D Sbjct: 193 ---GQGEQDVRDATERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVD---------GE 240 Query: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353 + ++ L++ G TTT L +L + P + +V+ + L+ G Sbjct: 241 RLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPG-------- 292 Query: 354 DKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKY 413 + E LR + + TS + V G IPK V+ L + + D + Sbjct: 293 ----------AIEEALRVLSPS-AALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQ 341 Query: 414 WRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + DPEV+ P R D + +F F G CLG LAR+E + AL RF Sbjct: 342 FTDPEVYDPTR--DPNPHFG-------FGRGIHFCLGAPLARLEGRVALNALFDRF 388 >2WX2-A nrPDB Length = 473 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 84/454 (18%), Positives = 171/454 (37%), Gaps = 35/454 (7%) Query: 35 RPMGFPPGPPGLPFIGNIYSLAASSELPHVYM-RKQSQVYGEIFSLDLGGISTVVLNGYD 93 RP P P +PF+G+I + P +M R + + +F++ +GG ++ Sbjct: 14 RPTDPPVYPVTVPFLGHIVQFGKN---PLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPH 70 Query: 94 VVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD----HRRLAVNSFRYFGY 149 ++EI + R + + G + Y R L + F+ F Sbjct: 71 EHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVP 130 Query: 150 GQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQH 209 + K + E ++ + + + + N +FGE + + +H Sbjct: 131 AIQHEVRKFMAENWKEDEGV-------INLLEDCGAMIINTACQCLFGEDLR-KRLNARH 182 Query: 210 MIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRK 269 +L S+ A+VF+ PW+ LP + + A + L +I + ++ Sbjct: 183 FAQLLSKMESSLIPAAVFM----PWLLRLPLPQSARCREARAELQKILGEII--VAREKE 236 Query: 270 PQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALY 329 + L + + + S + + + AG T+T W++L + Sbjct: 237 EASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHP 296 Query: 330 PNIQ--GQVQKEIDLIMGPNGKPSWDDKC-KMPYTEAVLHEVLRFCNIVPLGIFHATSED 386 N + ++ KEID + ++D+ +MP+ E + E +R + L + + Sbjct: 297 KNKKWLDKLHKEIDEF---PAQLNYDNVMDEMPFAERCVRESIRR-DPPLLMVMRMVKAE 352 Query: 387 AVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRR 446 V Y +PKG + + H DE+ + +P ++ PER G F + F G Sbjct: 353 VKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAF------IGFGAGVH 406 Query: 447 HCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD 480 C+G+ A +++ + + + VPD Sbjct: 407 KCIGQKFALLQVKTILATAFREYDFQLLRDEVPD 440 >1ODO-A nrPDB Length = 408 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 105/254 (41%), Gaps = 37/254 (14%) Query: 249 NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI 308 N A +Y+ L +LI + + A DE D + S E L ++ +I Sbjct: 187 NTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDR------LSPEELRDTLLLMI 240 Query: 309 IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368 AG ETT NV+ A+ + P+ V+K G+ +W D V+ E Sbjct: 241 SAGYETTVNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD---------VVEET 282 Query: 369 LRFCNIVP-LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427 LR V L + +A ++ A+ G +I +G ++ + + + + D + F R + Sbjct: 283 LRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTV- 341 Query: 428 SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHELVPDLKPR 484 KE L F G CLG LARME+ L +L RF L P E +P + Sbjct: 342 -------KEHLA-FGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPSL 393 Query: 485 LGMTLQPQPYLICA 498 + Q P L+ A Sbjct: 394 ISNGHQRLPVLLHA 407 >5CJE-A nrPDB Length = 393 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 35/232 (15%) Query: 237 ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFS 296 + P G +L Y+ L+ +++ +++ P D L ++ + + + S Sbjct: 168 VAPTGGDAEL-----AAYERLAAYLDELIDDKRSTAP---ADDLLGDLIRTRAEDDDRLS 219 Query: 297 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356 E L L++AG ETT N++ + + +P+ ++ ++ L+ G Sbjct: 220 GEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDG----------- 268 Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416 + EVLRF V + +E + G +I +G V+ L + D D Sbjct: 269 -------AVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPD 321 Query: 417 PEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 P VF R G+ A F G +CLG LAR+E + +LL+R Sbjct: 322 PHVFDIHRA--PQGHLA-------FGHGIHYCLGAPLARLEARVALRSLLER 364 >3L4D-A nrPDB Length = 453 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 90/432 (20%), Positives = 164/432 (37%), Gaps = 37/432 (8%) Query: 47 PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIF 106 PF+G+I P +M K + YG IF++++ G V+ + ++EI Sbjct: 13 PFVGHIIQFGKD---PLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEIL 69 Query: 107 ADRPCLPLFMKMTKMGGLLNSRYGRGWVD----HRRLAVNSFRYFGYGQKSFESKILEET 162 + R + + G + Y R L V F ++F I E Sbjct: 70 SPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKF-------QNFAPSIQHEV 122 Query: 163 KFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAA 222 + F A + + + N +FGE + D + +L ++ Sbjct: 123 RKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLR-KRLDARQFAQLLAKMESCLI 181 Query: 223 SASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD 282 A+VFL PWI LP + + A + D LS +I A + Q + D Sbjct: 182 PAAVFL----PWILKLPLPQSYRCRDARAELQDILSEII-IAREKEEAQKDTNTSDLLAG 236 Query: 283 EMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQ--GQVQKEI 340 + D + S+ + + + AG T+T W++L + N + ++ +EI Sbjct: 237 LLGAVYRD-GTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEI 295 Query: 341 DLIMGPNGKPSWDDKCK-MPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG-YSIPKGT 398 D + ++D+ + MP+ E E +R PL + V G Y +P+G Sbjct: 296 DEF---PAQLNYDNVMEEMPFAEQCARESIR--RDPPLVMLMRKVLKPVQVGKYVVPEGD 350 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLD-SSGYFAKKEALVPFSLGRRHCLGEHLARME 457 + + H DE+ + +P ++PER + G F F G C+GE ++ Sbjct: 351 IIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCG------FGAGVHKCIGEKFGLLQ 404 Query: 458 MFLFFTALLQRF 469 + +L+ + Sbjct: 405 VKTVLATVLRDY 416 >4UBS-A nrPDB Length = 393 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 97/230 (42%), Gaps = 38/230 (16%) Query: 264 ASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAI 323 A ++RK + P D LD++ Q + + T + L+ L+IAG ETT N++ Sbjct: 190 ALIDRKRKEPG---DGLLDDLIQEQLN-RGTVDRAELVSLATLLLIAGHETTANMISLGT 245 Query: 324 LFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHAT 383 + +P +++ E L MP A + E+LRF +I G+ Sbjct: 246 FTLLRHPEQLAELRAEPGL---------------MP---AAVEELLRFLSIAD-GLLRVA 286 Query: 384 SEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSL 443 +ED V G +I V+ ++ D + +P D+ + V F Sbjct: 287 TEDIEVAGTTIRADEGVVFATSVINRDAAGFAEP---------DALDWHRSARHHVAFGF 337 Query: 444 GRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELVPDLKPRLGMTLQ 490 G CLG++LAR EM + L +R L P + +P KP G T+Q Sbjct: 338 GIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIP-FKP--GDTIQ 384 >3ABA-A nrPDB Length = 403 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 80/375 (21%), Positives = 133/375 (35%), Gaps = 81/375 (21%) Query: 123 GLLNSRYGRG---WVDH------RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYK 173 G++ + GRG W D R+L F ++ I DAIE + Sbjct: 76 GVVTQKPGRGSLLWQDEPEHTSDRKLLAKEFTV--RRMQALRPNIQRIVDEHLDAIEA-R 132 Query: 174 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 233 G P D + NAV ++ +FG +FQ + E + AA+ A Sbjct: 133 GGPVDLVKTFANAVPSMVISDLFGVPVERR-AEFQDIAEAMMRVDQDAAATEA----AGM 187 Query: 234 WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS 293 +G L + Q+ R A D +S LI DP Sbjct: 188 RLGGLLYQLVQE--RRANPGDDLISALITT-------------------------EDPDG 220 Query: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353 L+ + G L+IA +TT ++ + P+ ++++ L+ Sbjct: 221 VVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPSLVGN-------- 272 Query: 354 DKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKY 413 + E+LR+ I G + D + G I KG V+ ++ + FD + Sbjct: 273 ----------AVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAF 322 Query: 414 WRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---- 469 +PE F R + + F G C+G+ LAR+E+ + F L +R Sbjct: 323 VEEPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLR 373 Query: 470 ------HLHFPHELV 478 L F H++V Sbjct: 374 LAKPVEELRFRHDMV 388 >3A1L-A nrPDB Length = 425 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 48/179 (26%), Positives = 76/179 (42%), Gaps = 28/179 (15%) Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 D S S + ++ + L+ AG ETTTN L A+L + + ++ +++ P Sbjct: 233 RDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTT------PES 286 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 P A + E++R+ V + ED + + IP+G+ V+ L S + Sbjct: 287 TP------------AAVEELMRYDPPV-QAVTRWAYEDIRLGDHDIPRGSRVVALLGSAN 333 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 D + DP+V R E V F LG +CLG LAR E + ALL Sbjct: 334 RDPARFPDPDVLDVHR---------AAERQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >6B11-A nrPDB Length = 440 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 85/188 (45%), Gaps = 28/188 (14%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 S +++ + L+ AG ETT +++ ++L + +P ++ L+ G Sbjct: 264 LSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWRELTVNPGLLPG--------- 314 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 + E+LR+ +I G+ + + D + G++I G ++ L + + DE + Sbjct: 315 ---------AVDELLRYLSIAD-GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVF 364 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474 +PE F R A++ V F G CLG++LARME+ + A+L+R P Sbjct: 365 SEPEAFDIHRS-------ARRH--VAFGYGPHQCLGQNLARMELEVALGAVLERLPALRP 415 Query: 475 HELVPDLK 482 V L+ Sbjct: 416 TTDVAGLR 423 >3R9C-A nrPDB Length = 418 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 48/175 (27%), Positives = 74/175 (42%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 +++ +I + L+IAG ETT N++ A L M P GQ + +G Sbjct: 241 LTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTP---GQWAA-----LAADGS----- 287 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 AV+ E +R+ V L + +D + +++PKG T++ L + H D Sbjct: 288 -----RASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIV 341 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 P+ F P+R F K G CLG LAR+E + AL RF Sbjct: 342 GAPDRFDPDRAQIRHLGFGK---------GAHFCLGAPLARLEATVALPALAARF 387 >3IVY-A nrPDB Length = 433 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 98/236 (41%), Gaps = 49/236 (20%) Query: 249 NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI 308 ++A + + ++ E+ + N + + A +D S + F V L Sbjct: 216 SSAELIGYAMKMAEEKAKNPADDIVTQLIQADID---------GEKLSDDEFGFFVVMLA 266 Query: 309 IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368 +AG ETT N + ++ A +P+ Q ++ K++ +P E E+ Sbjct: 267 VAGNETTRNSITQGMMAFAEHPD-QWELYKKV--------RP-----------ETAADEI 306 Query: 369 LRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427 +R+ P+ F T+ D + G I KG V+ S +FDE+ ++DP F+ R + Sbjct: 307 VRWA--TPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPN 364 Query: 428 SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483 F G +C+G +LARM + L F A+ +PDLKP Sbjct: 365 PHVGFG--------GTGAHYCIGANLARMTINLIFNAVADH---------MPDLKP 403 >2RFC-A nrPDB Length = 343 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 67/163 (41%), Gaps = 31/163 (19%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LII G ETTTN++ I + P+I DD K + Sbjct: 185 LIIGGNETTTNLIGNMIRVIDENPDI-------------------IDDALKN--RSGFVE 223 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E LR+ + + +ED+ + I KG VI L S + DE ++ +P++F Sbjct: 224 ETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFK----- 278 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 ++E + F +G CLG LAR+E + +L F Sbjct: 279 -----IGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >5JLC-A nrPDB Length = 515 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 96/226 (42%), Gaps = 28/226 (12%) Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCK 357 NL+ V ++ G T+ W +L +A P++Q ++ +E ++ + K ++DD Sbjct: 288 NLLIGV---LMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQN 344 Query: 358 MPYTEAVLHEVLRFCNIVPL-GIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYW 414 MP ++ E LR + PL +F D + Y +P+ V+ + H E+++ Sbjct: 345 MPLLNQMIKETLRLHH--PLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFF 402 Query: 415 RDPEVFHPERFLDSS-------------GYFAKKEAL----VPFSLGRRHCLGEHLARME 457 P F+ R+ + G+ A + + +PF GR C+GE A + Sbjct: 403 PKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQ 462 Query: 458 MFLFFTALLQRFHLHFPH--ELVPDLKPRLGMTLQPQPYLICAERR 501 + + + ++ +P E VP +TL P I E+R Sbjct: 463 LGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKR 508 >2Y5N-A nrPDB Length = 417 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 99/230 (43%), Gaps = 43/230 (18%) Query: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303 +++ A Y ++ LI++ R+ + V A + Q ++ S +E L + Sbjct: 197 EEMQEAAEQAYAYMGDLIDR----RRKEPTDDLVSALV----QARDQQDSLSEQELLDLA 248 Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363 +G L++AG E+TT + + + P ++ Q+ +LI PS Sbjct: 249 IG-LLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELI------PS------------ 289 Query: 364 VLHEVLRFCNIVPLGIFHA----TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 + E+ R+ VPLG+ A ED +RG +I G V+ + + + D+ + D + Sbjct: 290 AVEELTRW---VPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADR 346 Query: 420 FHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 +R + + F G HCLG LAR+E+ + LLQR Sbjct: 347 IDVDRTPNQH---------LGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >2ZBZ-A nrPDB Length = 412 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 86/212 (40%), Gaps = 39/212 (18%) Query: 282 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 341 D++ G+ D +E LI + L+IAG ETT ++ +++ + +P ++ + Sbjct: 222 DQLANGEID------REELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRS 275 Query: 342 LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVI 401 L+ G + E+LR+ I + + D V G I G VI Sbjct: 276 LVPG------------------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVI 317 Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLF 461 + D + DP+ R + + A F G CLG++LAR+E+ + Sbjct: 318 VVNSIANRDGTVYEDPDALDIHR--SARHHLA-------FGFGVHQCLGQNLARLELEVI 368 Query: 462 FTALLQR---FHLHFPHELVPDLKPRLGMTLQ 490 AL+ R L P V L R G T+Q Sbjct: 369 LNALMDRVPTLRLAVP---VEQLVLRPGTTIQ 397 >6CR2-A nrPDB Length = 477 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/182 (22%), Positives = 82/182 (45%), Gaps = 20/182 (10%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVL 365 L++AG ++++ W +L +A P+I ++ +E ++G + P ++D+ K+ V+ Sbjct: 258 LLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVI 317 Query: 366 HEVLRFCNIVPLGIFHATSEDAVVRG--YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 E LR + I A V G Y IP V+++ E+++ +P ++P Sbjct: 318 KETLRLHAPI-HSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPH 376 Query: 424 RFLDSSGYFAKKEALV----------------PFSLGRRHCLGEHLARMEMFLFFTALLQ 467 R+ ++ A+ + V PF GR C+GE A +++ L++ Sbjct: 377 RWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVR 436 Query: 468 RF 469 F Sbjct: 437 LF 438 >1EHE-A nrPDB Length = 403 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 39/176 (22%), Positives = 70/176 (39%), Gaps = 34/176 (19%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L++AG T N++ + +A +P+ Q++ P+ P + + Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLK------ANPSLAPQF------------VE 277 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E+ R+ L I ED ++ + +I + S + DE+ + +P+ F+ R Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLK 482 F G C+ EHLA+ E+ F+ L Q+F PDLK Sbjct: 338 PPQDPLG-------FGFGDHRCIAEHLAKAELTTVFSTLYQKF---------PDLK 377 >4TRI-A nrPDB Length = 407 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 S + ++F ++I G ETT + L + + + + ++DL+ G Sbjct: 218 MSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPG--------- 268 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 + E+LR+ + V + + D V G + G ++ S +FDE + Sbjct: 269 ---------AIEEMLRWTSPVK-NMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVF 318 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DP+ F +R +S V F G CLG LAR+E+ L +L+R Sbjct: 319 GDPDNFRIDRNPNSH---------VAFGFGTHFCLGNQLARLELRLMTERVLRRL 364 >1UE8-A nrPDB Length = 367 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/166 (28%), Positives = 69/166 (41%), Gaps = 31/166 (18%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+IAG ETTTN++ AI LY SWD + +AV Sbjct: 207 LMIAGNETTTNLIGNAIEDFTLYN--------------------SWDYVREKGALKAV-E 245 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E LRF V + T E +R I +G V + S + DE+ ++DP+ F P+R Sbjct: 246 EALRFSPPV-MRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTP 304 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 472 + + F G CLG LAR+E + ++F + Sbjct: 305 NPH---------LSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >2W0A-A nrPDB Length = 455 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/177 (23%), Positives = 76/177 (42%), Gaps = 4/177 (2%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 FS + + ++ AG T++ W ++ + + + V E+D + G S+ Sbjct: 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV-VRGYSIPKGTTVITNLYSVHFDEKY 413 ++P E VL E LR PL I ++ V+G+ I +G V + + + Sbjct: 301 LRQIPQLENVLKETLRLHP--PLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPED 358 Query: 414 WRDPEVFHPERFLD-SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + DP F P R+ + +PF GR C+G A M++ F+ LL+ + Sbjct: 359 FPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREY 415 >6FYJ-A nrPDB Length = 421 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/280 (22%), Positives = 113/280 (40%), Gaps = 52/280 (18%) Query: 223 SASVFLYNAFPWIGI-LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH------ 275 + + A W G+ + + ++L +N +++ A+V K L +H Sbjct: 142 AKEIMCRTACQWAGVPVQENEVKRLTKNLGAMFE------SAAAVGLKHWLGRHARNYEE 195 Query: 276 -FVDAYLDEMDQGK-NDPSSTFSKENLIFSVGELIIAGTETTT----NVLRWAILFMALY 329 +++ +D + GK N P +T + + E + TET N+LR I+ +A++ Sbjct: 196 IWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILR-PIVAIAIF 254 Query: 330 PNIQGQVQKEIDLIMGPNGKPSWDDKCK---MPYTEAVLHEVLRFCNIVPLGIFHATSED 386 N + + + P +K K Y++ + EV RF P + +D Sbjct: 255 INF---------IALALHHYPEEKEKLKSGDKKYSQMFVQEVRRFYPFFPF-VVALVKKD 304 Query: 387 AVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS---- 442 +GY +GT + +LY + D + W++P+VF P+RF G PFS Sbjct: 305 FTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEG--------SPFSFIPQ 356 Query: 443 ------LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476 +G R C GE + M + L R P + Sbjct: 357 GGGDYFMGHR-CAGEWVTIEVMKVSLDYLTNRMDYEVPDQ 395 >5EX6-C nrPDB Length = 434 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 31/180 (17%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 T + E L ++++AG + + ++ +L + P ++ ++ Sbjct: 254 GDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV----------- 302 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 P E + E++R+ + ED+ V I G TV+ +L + + Sbjct: 303 -------PAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTAN--- 352 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEAL--VPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 RDP + LD + +EA+ V F G HCLG LAR+E+ + +TAL +RF Sbjct: 353 ---RDPALLPDADRLDVT-----REAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >4WPZ-A nrPDB Length = 397 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 97/233 (41%), Gaps = 36/233 (15%) Query: 240 FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKEN 299 G QQ+ A ++ E +V R ++ D + E+ + S+ +E Sbjct: 168 LGDWQQVVEKEAATVSLVNYFGELIAVKR-----ENPADDLISELIAISDGDSTLTEREI 222 Query: 300 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 359 + S+G ++ AG ETT N + ++ + P +E+D + D++ +P Sbjct: 223 IALSIG-ILSAGHETTANQISMFLVTLLHNP-------EELDKLR--------DNREAIP 266 Query: 360 YTEAVLHEVLRFCNIVPLGIF---HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416 + E+LRF + G T+E + G +P G V+ + + + RD Sbjct: 267 KA---VDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATAN------RD 317 Query: 417 PEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 PEVF L+ + + + F G HCLG LAR+E+ A+L R Sbjct: 318 PEVFEDGERLNVT---RENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRM 367 >1CPT-A nrPDB Length = 428 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 55/107 (51%), Gaps = 12/107 (11%) Query: 364 VLHEVLRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 ++ E +R+ P+ F T+ D VRG +I +G ++ + S + DE+ + +P+ F Sbjct: 303 LVDEAVRWT--APVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDI 360 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 RF + + F G CLG+HLA++EM +FF LL + Sbjct: 361 TRFPNRH---------LGFGWGAHMCLGQHLAKLEMKIFFEELLPKL 398 >5HIW-A nrPDB Length = 398 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 10/105 (9%) Query: 365 LHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPER 424 + E R+C+ GI +A + G ++ GT + +L + H+DE+ + PE F R Sbjct: 265 IEESTRWCSSAA-GIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR 323 Query: 425 FLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + ++ F G +C+G LARME + + LL+RF Sbjct: 324 ---------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >2FR7-A nrPDB Length = 412 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 83/199 (41%), Gaps = 31/199 (15%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 + + E V L+ AG +TT N + A+ +A +P+ +++ + L Sbjct: 233 TGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSL--------- 283 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 E +RF + V F T+ D + G +I +G V+ L S + D Sbjct: 284 ---------ARNAFEEAVRFESPVQT-FFRTTTRDVELAGATIGEGEKVLMFLGSANRDP 333 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471 + W DP+ + R +SG+ V F G C+G+ +AR+E + AL ++ Sbjct: 334 RRWDDPDRYDITR--KTSGH-------VGFGSGVHMCVGQLVARLEGEVVLAALARKVAA 384 Query: 472 HFPHELVPDLKPRLGMTLQ 490 E+ LK R TL+ Sbjct: 385 ---IEIAGPLKRRFNNTLR 400 >5VWS-A nrPDB Length = 393 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 28/172 (16%) Query: 298 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCK 357 E ++ + L++AG TTT ++ +L + +P + V+ + LI Sbjct: 221 EEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADPSLI-------------- 266 Query: 358 MPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 417 A L E LR + L T+ D + G +IP V+ + S + D++ + DP Sbjct: 267 ----PAALEESLRLRSPF-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDP 321 Query: 418 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 E F R ++G+ A F G CLG L R+E + LL RF Sbjct: 322 ERFDLHR--QTTGHIA-------FGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >6GK6-A nrPDB Length = 411 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 35/238 (14%) Query: 234 WIGIL--PFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 291 W IL P + + R VV +F + A RK L E + K P Sbjct: 171 WTKILLAPAKDREFVERAQPVVEEFAAYFRALADARRKAPRDDLISGLLLAEEQEHKLSP 230 Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 + S ++F L++AG ETT +++ +L + +P + ++ ++ L+ Sbjct: 231 AELSS---MVFL---LLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPGLV-------- 276 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 + + E LR L + ED + G +P G V L + + D Sbjct: 277 ----------GSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDP 326 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 +++ DP+ F R + + F G CLG LAR+E + F+ LL+R Sbjct: 327 QHFPDPDRFDIGRSPNRH---------IGFGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >4MM0-A nrPDB Length = 399 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 73/165 (44%), Gaps = 31/165 (18%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L++AG E +N L ++L + +P+ +++++ L+ PS + Sbjct: 233 LLLAGYEPASNQLGSSVLTLLRFPDRLAELRRDPGLL------PS------------AVE 274 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E++R+ +F T ED + IP + V+ + + ++D P RF Sbjct: 275 ELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWD-----------PRRFD 323 Query: 427 DSSGYFAKKEALVPFSLGR--RHCLGEHLARMEMFLFFTALLQRF 469 D +G + +LG CLG LAR+E+ + ALL+RF Sbjct: 324 DPTGLRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >3AWQ-A nrPDB Length = 415 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 1/66 (1%) Query: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 Y E + EV RF P + A S+D G + P+G V+ +LY + D W DP+ Sbjct: 273 YAELFVQEVRRFYPFFPAVVARA-SQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 420 FHPERF 425 F PERF Sbjct: 332 FRPERF 337 >4RM4-A nrPDB Length = 396 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 S E LI L++AG ETTTN++ A+ + P + +++ +L Sbjct: 224 LSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPEL------------ 271 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 MP + E LRF P+ + D + G+ I +G V+ + S + DE + Sbjct: 272 ---MPQA---VEEALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKF 324 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 P +F R + + F G CLG LAR+E + T+L+ F Sbjct: 325 DRPHMFDIRRHPNPH---------IAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >5XW2-A nrPDB Length = 419 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 68/163 (41%), Gaps = 28/163 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+IAG TTT ++ +L + YP +V+ + LI G +L Sbjct: 253 LLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLIPG------------------LLE 294 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E +RF + V + AT+ D V G + V+ + + D + + +PE+F R Sbjct: 295 ESMRFLSPV-AATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTRGP 353 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + F + G CLG LARME + LL RF Sbjct: 354 NPHLGFGR---------GIHFCLGGPLARMEGRVALDHLLDRF 387 >6CVC-A nrPDB Length = 433 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 89/215 (41%), Gaps = 37/215 (17%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + + L + VN L V+A +D G+ SS + + F + L++AG ETT Sbjct: 226 YATALADDRRVNHHGDLTTSLVEAEVD----GERLSSSEIA---MFFIL--LVVAGNETT 276 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 N + +L ++ YP+ + + + D + + E++R+ + V Sbjct: 277 RNAISHGMLALSRYPDERAKWWSDFDGLAA-----------------TAVEEIVRWASPV 319 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 + + S+D +RG + G V S + DE+ + DP F R Sbjct: 320 -VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR---------NP 369 Query: 436 EALVPFSLGRRH-CLGEHLARMEMFLFFTALLQRF 469 V F G H CLG +LAR E+ + F L ++ Sbjct: 370 NPQVGFGGGGAHFCLGANLARREIRVVFDELRRQM 404 >4DO1-A nrPDB Length = 410 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 30/166 (18%) Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK-EIDLIMGPNGKPSWDDKCKMPYTE 362 V L+ AG +TT N + A+ +A +P G++Q+ D + N Sbjct: 243 VRSLLSAGLDTTVNGIGAAVYCLARFP---GELQRLRSDPTLARN--------------- 284 Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 E +RF + V F T+ + + G I +G V+ L S + D + W DP+++ Sbjct: 285 -AFEEAVRFESPVQT-FFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDI 342 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 R K V F G C+G+ +AR+E + +AL ++ Sbjct: 343 TR---------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARK 379 >6GII-A nrPDB Length = 479 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 10/119 (8%) Query: 352 WDDKCKMP-YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 W + C P A E LR+ V G T+ + V G +P G ++ + S + D Sbjct: 331 WREICADPSLIPAAAEECLRYNGPV-AGWRRRTTREVEVEGVRLPVGANILMVVASANHD 389 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 ++ DPE F R + + F G CLG +L RMEM + L +R Sbjct: 390 SAHFDDPEFFDIGR--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRL 440 >5FOI-A nrPDB Length = 408 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 76/175 (43%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + + L+ + L+ AG ET+ N + ++L + +P +++++ +L+ PN Sbjct: 232 ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPELM--PNA------ 283 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 + E+LR+ +I G+ A + D V+ ++I G +I L S + D + Sbjct: 284 ----------VDELLRYHSIAD-GLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTF 332 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 F R V F G CLG++LAR+EM + L +R Sbjct: 333 GAEATFDIHR---------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRV 378 >5Y1I-A nrPDB Length = 403 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 23/163 (14%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+ AG ETT N++ L + P +V+ D + N + Sbjct: 234 LLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN----------------TVE 277 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E+LR+ I + +ED + G I G ++ L + ++D + PE P+R L Sbjct: 278 ELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLY--PEA--PDR-L 332 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D A++ + F G CLG LAR+E+ + ++ LL+R Sbjct: 333 DIHRANARRH--LAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >2X9P-A nrPDB Length = 404 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 35/179 (19%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+ AG ++ +++ ++ +A +P+ + + D++ E VL Sbjct: 238 LLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMAR--------------AVEEVLR 283 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 +++P SED G +I G V+ +L +FDE+ + PE F R Sbjct: 284 TARAGGSVLP---PRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTP 340 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 + + F G HC+G LAR+E+ FT L R P+L+P L Sbjct: 341 NPH---------LTFGHGIWHCIGAPLARLELRTMFTKLFTRL---------PELRPEL 381 >4XE3-A nrPDB Length = 407 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 10/129 (7%) Query: 363 AVLHEVLRFCNIVPLGIF-HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 A + E+LR+ +V G F +ED + ++ G + + S + RD EVF Sbjct: 279 AAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASAN------RDEEVFD 332 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDL 481 LD + ++ + F G HC+G L R+E+ +AL++RF E V L Sbjct: 333 HADELD---FHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGL 389 Query: 482 KPRLGMTLQ 490 K + GM ++ Sbjct: 390 KWKQGMLIR 398 >1LG9-A nrPDB Length = 398 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 74/166 (44%), Gaps = 31/166 (18%) Query: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365 ++++AG + + ++ +L M +P ++ID G D++ + + Sbjct: 232 QVMLAGDDNISGMIGLGVLAMLRHP-------EQIDAFRG-------DEQS----AQRAV 273 Query: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E++R+ + ED + G I KG +VI +L + + RDP + Sbjct: 274 DELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAAN------RDPALAPDVDR 327 Query: 426 LDSSGYFAKKEAL--VPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 LD + +E + V F G HCLG LAR+E+ FT L +RF Sbjct: 328 LDVT-----REPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >1UED-A nrPDB Length = 406 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 52/228 (22%), Positives = 89/228 (39%), Gaps = 29/228 (12%) Query: 244 QQLFRNAAVVYDFLSRLIEKASVNR--KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 301 +++ RNA + +R + A+ NR L + D + D + E L Sbjct: 177 RRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDNVTDEELK 236 Query: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 361 LI+ G ET ++ + +L + P GQ++ L P Sbjct: 237 GLCTALILGGVETVAGMIGFGVLALLDNP---GQIEL---LFESPE------------KA 278 Query: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 E V++E++R+ + V +D V+ G I G V+ ++ + DE DP+V Sbjct: 279 ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLD 338 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 R S V F G +C+G LAR + + + L +RF Sbjct: 339 ANRAAVSD---------VGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >3EJB-B nrPDB Length = 404 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 86/214 (40%), Gaps = 38/214 (17%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + LI+K R PQ Q + L ++ K ++E + L IAG ETT Sbjct: 190 YFKELIQKR--KRHPQ--QDMISMLLKGREKDK------LTEEEAASTCILLAIAGHETT 239 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 N++ ++L + +P ++++ DLI + E LR+ + Sbjct: 240 VNLISNSVLCLLQHPEQLLKLRENPDLI------------------GTAVEECLRYESPT 281 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 + SED + G +I +G V L + + D + +P+VF R + Sbjct: 282 QMTA-RVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNPH------ 334 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + F G CLG LAR+E + LLQR Sbjct: 335 ---LSFGHGHHVCLGSSLARLEAQIAINTLLQRM 365 >5LIV-A nrPDB Length = 450 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 69/164 (42%), Gaps = 29/164 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LI+ G ETT+ ++ I + +P+ +V+++ L+ A + Sbjct: 276 LILGGYETTSWLVANTIHALLAHPDTLARVRQDPSLL------------------PAAIE 317 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF- 425 E +R+C G+ D + ++ GT V + ++DE + PEV+ +R Sbjct: 318 EGMRWCP-SSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKP 376 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 L ++ F G C+G LARME + ALL RF Sbjct: 377 LPAANVFGG---------GAHFCVGAPLARMEARVGLQALLARF 411 >5FYF-A nrPDB Length = 470 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 76/164 (46%), Gaps = 29/164 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LI+ G +TT N + ++ M +P +++ + +LI PN ++ Sbjct: 304 LIVGGNDTTRNSMSGGLVAMNEFPREFEKLKAKPELI--PN----------------MVS 345 Query: 367 EVLRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E++R+ PL + +D + G +I KG V+ S + DE+ + +P+ F +R Sbjct: 346 EIIRWQ--TPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR- 402 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D+ + + F G C+G LA +++ + + +L+RF Sbjct: 403 KDARNHMS-------FGYGVHRCMGNRLAELQLRILWEEILKRF 439 >2X2N-A nrPDB Length = 475 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 71/175 (40%), Gaps = 11/175 (6%) Query: 308 IIAGTETTTNVLRWAILFMALYPNIQ--GQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365 + AG T++ W++L + N++ ++KEI+ + D+ MP+ E Sbjct: 275 MFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMDE--MPFAERCA 332 Query: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E +R + L + D V Y +PKG + + H DE+ + +P + PER Sbjct: 333 RESIRR-DPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERD 391 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD 480 G F + F G C+G+ +++ + + + VPD Sbjct: 392 EKVEGAF------IGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPD 440 >6M7L-A nrPDB Length = 404 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 12/108 (11%) Query: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 E + E++R+ ++ +ED + G I KG V +L + + DP Sbjct: 278 EQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAAN-----RADPA--- 329 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 LD K+ V F G HCLG LARME+ + FT L+ RF Sbjct: 330 ----LDGFDITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >2WIO-A nrPDB Length = 431 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 37/119 (31%), Positives = 53/119 (44%), Gaps = 9/119 (7%) Query: 352 WDDKCKMP-YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 WD + P A++ EVLR+ P + T++ V G IP V T + S + D Sbjct: 284 WDAAAEDPGRIPAIVEEVLRYRPPFP-QMQRTTTKATEVAGVPIPADVMVNTWVLSANRD 342 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 DP+ F P R SG A+ + F G CLG LAR+E + ++ RF Sbjct: 343 SDAHDDPDRFDPSR---KSGGAAQ----LSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >6F88-A nrPDB Length = 400 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 69/164 (42%), Gaps = 29/164 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LI+ G ETT+ ++ I + +P+ +V+++ L+ A + Sbjct: 226 LILGGYETTSWLVANTIHALLAHPDTLARVRQDPSLL------------------PAAIE 267 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF- 425 E +R+C G+ D + ++ GT V + ++DE + PEV+ +R Sbjct: 268 EGMRWCP-SNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKP 326 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 L ++ F G C+G LARME + ALL RF Sbjct: 327 LPAANVFGG---------GAHFCVGAPLARMEARVGLQALLARF 361 >6F0B-A nrPDB Length = 395 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 67/163 (41%), Gaps = 27/163 (16%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LI+ G +TT + + +++ AL P V + + I ++ Sbjct: 230 LIVGGYDTTASTISLSLVSYALQPEKFSVVHEHPERI------------------PLLVE 271 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E+LR+ + LG+ +ED V G ++ G V+ L + DE + +P Sbjct: 272 ELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNP--------- 322 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D + V F G C+G+ LAR+E+ A+++R Sbjct: 323 DELDFDRPSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL 365 >5Z9I-A nrPDB Length = 398 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 10/107 (9%) Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 A+L E +R+ + + G+ AT+ + V G IPK ++ + + DE+ + P+VF Sbjct: 272 ALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDA 330 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 R A + F G CLG LARME LL R Sbjct: 331 GR---------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRL 368 >1Z8P-A nrPDB Length = 404 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/228 (21%), Positives = 95/228 (41%), Gaps = 36/228 (15%) Query: 242 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 301 + +Q + A V +F+ L+E+ D L + + ++D S + L Sbjct: 181 RAEQRGQAAREVVNFILDLVERRRTEPG--------DDLLSALIRVQDDDDGRLSADELT 232 Query: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 361 L++AG E++ +++ + +P+ V+++ P+ P+ Sbjct: 233 SIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRD------PSALPN---------- 276 Query: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 + E+LR+ P +E+ + G +IP+ +TV+ + + D K + DP F Sbjct: 277 --AVEEILRYIA-PPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 R D+ G+ + F G C+G LA++E + AL RF Sbjct: 334 VTR--DTRGHLS-------FGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >3RWL-A nrPDB Length = 426 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/179 (22%), Positives = 76/179 (42%), Gaps = 29/179 (16%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 + + E + +V LI+ G +TT N + +L + P+ +++ L+ Sbjct: 247 TRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKLKANPALV-------- 298 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFD 410 E ++ E++R+ PL T+ D+ + G +I KG V+ YS + D Sbjct: 299 ----------ETMVPEIIRWQ--TPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRD 346 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 ++ PE F +R + + F G C+G LA M++ + + +L RF Sbjct: 347 DEVIDRPEEFIIDR--------PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >4JBT-A nrPDB Length = 410 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 85/197 (43%), Gaps = 30/197 (15%) Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 D + ++E +I ++ L+ AG ETT +++ A+ + +P +++ L+ +G Sbjct: 223 TDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHP-------EQLRLVR--DG 273 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 + W E + E LR+ V + +ED + IP+G V+ + ++ Sbjct: 274 EIGW---------ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIG 324 Query: 409 FD-EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 D + D + F R A + F G C G LAR+E + AL Sbjct: 325 RDITVHGADADDFDITR--------ATAARHISFGHGPHICPGAALARLEAAIALPALFT 376 Query: 468 RF-HLH--FPHELVPDL 481 RF HLH P + +P+L Sbjct: 377 RFPHLHPALPLDQIPNL 393 >6G71-A nrPDB Length = 405 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 12/97 (12%) Query: 363 AVLHEVLRFCNIVPLGIF-HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 AV E +R+ + P+G+ T D + GY IP+G + + S + D W DP+ F Sbjct: 271 AVFEESIRW--VAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFD 328 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 ER EA + F G CLG AR ++ Sbjct: 329 IER---------GSEAHLAFGKGVHVCLGAWAARSQV 356 >4Z5P-A nrPDB Length = 400 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/196 (22%), Positives = 81/196 (41%), Gaps = 35/196 (17%) Query: 278 DAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQ 337 D L + ++D E + F V L++AG ET+ + L + + + + ++ Sbjct: 206 DDLLGVLVSARDDDDRLTEDELITFGV-TLLVAGHETSAHQLGNMVYALLTHEDQLSLLR 264 Query: 338 KEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATS----EDAVVRGYS 393 ++ +L+ + E+LRF VPLG + ED + G + Sbjct: 265 EQPELL------------------PRAVEELLRF---VPLGNGVGNARIALEDVELSGGT 303 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHL 453 + G V+ + + D + + DP+ R +K + F G +CLG L Sbjct: 304 VRAGEGVVAAAVNANRDPRAFDDPDRLDITR---------EKNPHLAFGHGAHYCLGAQL 354 Query: 454 ARMEMFLFFTALLQRF 469 ARME+ + LL+RF Sbjct: 355 ARMELRVAIGGLLERF 370 >2UUQ-A nrPDB Length = 414 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 82/214 (38%), Gaps = 36/214 (16%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + + LIE+ H V A + D + T S F+ ++ G +T Sbjct: 203 YFTGLIERRRTEPADDAISHLVAAGVG----ADGDTAGTLSILAFTFT---MVTGGNDTV 255 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T +L ++ + P+ Q+ + L+ P G P + E+LR + V Sbjct: 256 TGMLGGSMPLLHRRPD-----QRRL-LLDDPEGIPD------------AVEELLRLTSPV 297 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEK-YWRDPEVFHPERFLDSSGYFAK 434 G+ T+ D + +IP G V+ S + DE+ Y D R Sbjct: 298 -QGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRC--------- 347 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 ++ FS G HCLG ARM+ + T LL R Sbjct: 348 PRNILTFSHGAHHCLGAAAARMQCRVALTELLAR 381 >5YHJ-A nrPDB Length = 413 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/209 (22%), Positives = 88/209 (42%), Gaps = 29/209 (13%) Query: 248 RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307 R++A V+ + +++++ NR LP Y E +++ +E + V + Sbjct: 184 RSSAEVW--IRQMVKEVRSNR--LLPNEHTALY--EFSWHRDESGELLPEEVVAVEVLNI 237 Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367 + + VL + +L + +P+++ QV++ ++ TE V E Sbjct: 238 LRPTVAISVYVL-FTVLALHQFPDVKEQVER-----------------GEVSKTEFV-QE 278 Query: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427 V RF P+ + D GY+ P+GT + +LY + D W +P+ F P RF D Sbjct: 279 VRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKD 337 Query: 428 --SSGYFAKKEALVPFSLGRRHCLGEHLA 454 S + + G R C GEH+ Sbjct: 338 WKESPFNFIPQGGGDVDFGHR-CAGEHVT 365 >4YT3-A nrPDB Length = 410 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 41/178 (23%), Positives = 81/178 (45%), Gaps = 32/178 (17%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN--IQGQVQKEIDLIMGPNGKPSW 352 F+ + ++ + ++ AG ETT+++L + + LY + + ++ + +DL+ P Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANS-FYSLLYDDKEVYQELHENLDLV--PQA---- 280 Query: 353 DDKCKMPYTEAVLHEVLRF-CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 + E+LRF N++ L ED + G + +G +V+ + + + DE Sbjct: 281 ------------VEEMLRFRFNLIKLD--RTVKEDNDLLGVELKEGDSVVVWMSAANMDE 326 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + + DP + R + + F G CLG LAR+E + TA L++F Sbjct: 327 EMFEDPFTLNIHR--------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKF 376 >6FSH-A nrPDB Length = 398 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 72/178 (40%), Gaps = 27/178 (15%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 T + E L +L++AG + + ++ +L + +P ++I + G Sbjct: 218 GDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHP-------EQIAALRG------ 264 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 DD+ + + E++R+ + ED +V I +G TV+ +L + D Sbjct: 265 -DDQS----ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDR 319 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D + R V F G HCLG L R+++ + +TAL +RF Sbjct: 320 ALLPDADRLDVTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >2WM5-A nrPDB Length = 435 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 55/246 (22%), Positives = 94/246 (38%), Gaps = 44/246 (17%) Query: 232 FPWIG-ILPFGK------HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEM 284 F W IL FG + + +A + + + L E VN L V+A +D Sbjct: 198 FHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGE 257 Query: 285 DQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIM 344 + +S F L++AG ETT N + +L ++ YP + + + D + Sbjct: 258 RLSSREIASFFIL---------LVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGL- 307 Query: 345 GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNL 404 + E++R+ + V + + ++D +RG + G V Sbjct: 308 ----------------APTAVEEIVRWASPV-VYMRRTLTQDIELRGTKMAAGDKVSLWY 350 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRH-CLGEHLARMEMFLFFT 463 S + DE + DP F R + F G H CLG +LAR E+ + F Sbjct: 351 CSANRDESKFADPWTFDLAR---------NPNPHLGFGGGGAHFCLGANLARREIRVAFD 401 Query: 464 ALLQRF 469 L ++ Sbjct: 402 ELRRQM 407 >4TX3-A nrPDB Length = 404 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 72/178 (40%), Gaps = 27/178 (15%) Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 T + E L +L++AG + + ++ +L + +P ++I + G Sbjct: 224 GDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHP-------EQIAALRG------ 270 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 DD+ + + E++R+ + ED +V I +G TV+ +L + D Sbjct: 271 -DDQS----ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDR 325 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 D + R V F G HCLG L R+++ + +TAL +RF Sbjct: 326 ALLPDADRLDVTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 374 >6A7J-A nrPDB Length = 411 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/217 (20%), Positives = 86/217 (39%), Gaps = 41/217 (18%) Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 ++++E+ N L + A D + E ++ ++ +I AG ETT Sbjct: 195 LFTKIVEEKKANPGDDLTSALIAASED---------GDHLTDEEILNTLQLIIAAGHETT 245 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 +++ + +A++P + +V +G+ W E V+ E LR+ Sbjct: 246 ISLIVNVVEALAIHPEQRKKVL---------SGEIPW---------EGVIEETLRWNTPT 287 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 + +ED V +PKG ++ + ++ DE E++ ++G F Sbjct: 288 SHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDE-----------EQYGPTAGDFDAT 336 Query: 436 EAL---VPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + F G C G L+R+E + AL +RF Sbjct: 337 RTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >5LIE-A nrPDB Length = 414 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 71/182 (39%), Gaps = 29/182 (15%) Query: 289 NDPSS-TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 +DP + S L L AG ETT N + +L +A P+ ++ + +L+ Sbjct: 231 DDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELL---- 286 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 + E++R+ + P S + G I G V+ S Sbjct: 287 --------------PTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSA 331 Query: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 + RDP VF D + K + F G +CLG +LAR+E+ + F LL Sbjct: 332 N------RDPSVFDRADEFDIT---RKPNPHLGFGQGVHYCLGANLARLELRVLFEELLS 382 Query: 468 RF 469 RF Sbjct: 383 RF 384 >5XNT-A nrPDB Length = 411 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 61/282 (21%), Positives = 112/282 (39%), Gaps = 59/282 (20%) Query: 234 WIGIL--PFGKHQQLFRN------AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMD 285 W+ IL PF K +Q N A Y +L ++ + +N + + A +D Sbjct: 168 WVDILFLPFDKEKQEEVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVD--- 224 Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN--IQGQVQKEIDLI 343 F+ + ++ + ++ AG ETT+++L + + LY + + ++ + +DL+ Sbjct: 225 ------GEMFTDDEVVRTTMLILGAGVETTSHLLANS-FYSLLYDDKEVYQELHENLDLV 277 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRF-CNIVPLGIFHATSEDAVVRGYSIPKGTTVIT 402 P + E+LR+ N++ L ED + G + +G V+ Sbjct: 278 --PQA----------------VEEMLRYRFNLIKLD--RTVKEDNDLLGVELKEGENVVV 317 Query: 403 NLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFF 462 + + + DE+ + D + R + + F G CLG LAR+E + Sbjct: 318 WMSAANLDEEMFEDAFTLNIHR--------PNNKKHLTFGNGPHFCLGAPLARLEAKIAL 369 Query: 463 TALLQRFHLHFPHELVPDLK-------PRLGMTLQPQPYLIC 497 T L++F H E VP + G TL P C Sbjct: 370 TTFLKKFK-HI--EAVPSFQLEDNLTDSATGQTLTSLPLKAC 408 >6A7I-A nrPDB Length = 411 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/178 (22%), Positives = 73/178 (41%), Gaps = 32/178 (17%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + E ++ ++ +I AG ETT +++ + + +P + +V NG+ WD Sbjct: 225 LTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVL---------NGEIGWD- 274 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 V+ E LR+ + +ED V +PKG +I + ++ DE Sbjct: 275 --------GVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDE--- 323 Query: 415 RDPEVFHPERFLDSSGYFAKKEAL---VPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 E++ ++G F + F G C G L+R+E + AL +RF Sbjct: 324 --------EQYGPTAGEFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >3TKT-A nrPDB Length = 450 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 12/107 (11%) Query: 363 AVLHEVLRFCNIVPLGIFHATSE-DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 ++ E +R+ P+ F T+ D + G I G ++ N + + D + +P F Sbjct: 324 GIVEEAIRWT--TPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFD 381 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 P R + + F G CLG HLAR+EM + LL R Sbjct: 382 PTRPANRH---------LAFGAGSHQCLGLHLARLEMRVLLDVLLDR 419 >2XKR-A nrPDB Length = 398 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/175 (22%), Positives = 69/175 (39%), Gaps = 28/175 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 S + L+ ++I G ETT + L + + +Q++ L+ G Sbjct: 215 LSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPG--------- 265 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 + E+LR+ V + + D G ++ G ++ S +FDE + Sbjct: 266 ---------AIEEMLRWTAPVK-NMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVF 315 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 +PE F +R +S + F G CLG LAR+E+ L +L+R Sbjct: 316 CEPEKFDVQRNPNSH---------LAFGFGTHFCLGNQLARLELSLMTERVLRRL 361 >5M0P-A nrPDB Length = 428 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 1/71 (1%) Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 K + Y EV R+ VP + D +G +IP G + ++Y DE W Sbjct: 278 KSEPDYAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLW 336 Query: 415 RDPEVFHPERF 425 DP F PERF Sbjct: 337 DDPNEFRPERF 347 >3WVS-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 75/185 (40%), Gaps = 34/185 (18%) Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 D +++ L+ L+IAG ETT + + + + P ++ + +LI Sbjct: 220 RDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPELI----- 274 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHAT----SEDAVVRGYSIPKGTTVITNL 404 PS + E+ RF VPLG A ED V G + G V+ L Sbjct: 275 -PS------------AVEELFRF---VPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVAL 318 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464 + + D + DPE +R S + + F G HCLG LAR+E+ A Sbjct: 319 GAANRDGLRFEDPEEIKLDR---PSNHH------IGFGHGIHHCLGAPLARLELQEALRA 369 Query: 465 LLQRF 469 LL+R Sbjct: 370 LLERL 374 >1GWI-A nrPDB Length = 411 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 75/175 (42%), Gaps = 25/175 (14%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + ++ ++ ++ AG ETT +++ A++ ++ +P Q+ + L +G+ W Sbjct: 227 LTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPE-----QRALVL----SGEAEW-- 275 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414 AV+ E LRF + +ED V IP G +I + ++ DE+ Sbjct: 276 -------SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERA- 327 Query: 415 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 P +RF D + + + F G C G L+RME + AL RF Sbjct: 328 HGPTA---DRF-DLTRTSGNRH--ISFGHGPHVCPGAALSRMEAGVALPALYARF 376 >4Z5Q-A nrPDB Length = 423 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 352 WDDKCKMPYT-EAVLHEVLRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHF 409 W C P A + E+LRF GI + ED V G + +G VI + +V+ Sbjct: 286 WTRLCADPEAIPAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNR 345 Query: 410 DEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 D + + + +R A +V F G HCLG HLAR+E+ AL++ Sbjct: 346 DGLVFDNADEVVIDR--------ADNRHMV-FGHGAHHCLGAHLARVELQEALKALVE 394 >2ZQJ-A nrPDB Length = 417 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 5/68 (7%) Query: 362 EAVLHEVLRFCNIVPLGIFHAT--SEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 E + EV R+ P G F +D V KGT+V+ +LY + D + W P+ Sbjct: 277 EMFVQEVRRY---YPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDE 333 Query: 420 FHPERFLD 427 F PERF + Sbjct: 334 FRPERFAE 341 >6HQD-A nrPDB Length = 420 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 39/176 (22%), Positives = 73/176 (41%), Gaps = 29/176 (16%) Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354 + + + ++ LI+ G +TT + + + + LYP +V+ L+ Sbjct: 244 LTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVRNNRALLA---------- 293 Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATS-EDAVVRGYSIPKGTTVITNLYSVHFDEKY 413 +V+ EV+R+ P+ T+ ED RG I KG V+ S + Sbjct: 294 --------SVIPEVVRWQ--TPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGN----- 338 Query: 414 WRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 RD EV +R +D + + F G CLG LA +++ + + + +R+ Sbjct: 339 -RDDEVI--DRPMDFIADRPRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERY 391 >3SN5-A nrPDB Length = 491 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 64/307 (20%), Positives = 109/307 (35%), Gaps = 48/307 (15%) Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLFRNAA 251 L IFG T DT H++ + FP + LP +FR A Sbjct: 168 LTIFGRDLTRRDTQKAHILNNLDNFKQFD--------KVFPALVAGLPI----HMFRTAH 215 Query: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII-- 309 + L+ + ++ ++ + + L + ND STF ++L + L++ Sbjct: 216 NAREKLAESLRHENLQKRESISE------LISLRMFLNDTLSTF--DDLEKAKTHLVVLW 267 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP----------SWDDKCKMP 359 A T W++ M P +E+ + G+ S + +P Sbjct: 268 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 327 Query: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVR----GYSIPKGTTVITNLYSVHFDEKYWR 415 ++++ E LR + L I ED + Y+I K + +H D + + Sbjct: 328 VLDSIIKESLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 385 Query: 416 DPEVFHPERFLDSSGY---------FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 DP F +R+LD +G K +PF G C G A E+ F +L Sbjct: 386 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 445 Query: 467 QRFHLHF 473 F L Sbjct: 446 SYFELEL 452 >1F4U-A nrPDB Length = 368 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 69/164 (42%), Gaps = 30/164 (18%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L+IAG ETTTN++ +++ + N+ ++++E Y +A+ Sbjct: 206 LLIAGNETTTNLISNSVIDFTRF-NLWQRIREE------------------NLYLKAI-E 245 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E LR+ V + T E + +I +G V + S + DE+ + D E F P+R Sbjct: 246 EALRYSPPV-MRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR-- 302 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + F G CLG LAR+E + +RF Sbjct: 303 -------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFR 339 >5DE9-A nrPDB Length = 410 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 11/94 (11%) Query: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF-HPERFLDSSGYFAKK 435 +G+ ED ++G I G V + + + RDPEVF P+R + Sbjct: 291 VGLSRIALEDVEIKGVRIRAGDAVYVSYLAAN------RDPEVFPDPDRI----DFERSP 340 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 V F G +C G LAR+E L A+L R Sbjct: 341 NPHVSFGFGPHYCPGGMLARLESELLVDAVLDRV 374 >2NZA-A nrPDB Length = 413 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 13/119 (10%) Query: 364 VLHEVLRF-CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 L E+LR+ + +G+ ED V G I G V + + + D + DP+ Sbjct: 280 ALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDL 339 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELV 478 +R D + + A + G C G LARM+ L LL+R L P E V Sbjct: 340 DR--DPNPHLA-------YGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQV 389 >6DCD-A nrPDB Length = 424 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 66/171 (38%), Gaps = 27/171 (15%) Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKM 358 +++ S L AG ETT +L A+ + P+IQ ++++ LI PN Sbjct: 241 DVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRENRSLI--PN----------- 287 Query: 359 PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPE 418 + E LR + V A V G I GT V+ + + D + + DP Sbjct: 288 -----FIEESLRMDSPVKSDSRLARKR-TTVGGLDIAAGTVVMVLPGAANRDPRRFEDPH 341 Query: 419 VFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 F +R + F+ G C G LAR+E + +L R Sbjct: 342 EFRLDR--------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >5L1U-A nrPDB Length = 401 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 11/94 (11%) Query: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR 445 D V I G V+ + + ++D++ + D +F R + + + F G Sbjct: 296 DITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRV--------RPRSHLAFGHGA 347 Query: 446 RHCLGEHLARMEMFLFFTALLQR---FHLHFPHE 476 RHC+G LAR+E+ F L +R L P E Sbjct: 348 RHCIGRTLARIELTAVFERLFRRLPDLRLAVPEE 381 >3NC3-A nrPDB Length = 441 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 2/107 (1%) Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 + E LR+ V L I S+D VV G I K T V + + + D + + P+VF+ Sbjct: 305 AIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIH 363 Query: 424 R-FLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 R L F+ + F G +C+G A+ E+ + +L + Sbjct: 364 REDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKM 410 >2WIY-A nrPDB Length = 394 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 8/108 (7%) Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 A+++E++R + L +ED + G I G+ + + + + D + + DP+VF Sbjct: 268 AIINEMVRM-DPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDH 326 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 R +S + F LG C G+ ++R E F L +R+ Sbjct: 327 TRPPAASRNLS-------FGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >5HDI-A nrPDB Length = 404 Score = 35.4 bits (80), Expect = 0.064, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 63/163 (38%), Gaps = 29/163 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L AG E+T +L A+ +A P+IQ QV+ +L+ A + Sbjct: 241 LFAAGGESTAALLGSAVWILATRPDIQQQVRANPELL------------------GAFIE 282 Query: 367 EVLRFCNIVPL-GIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E LR+ P G + + G +P + ++ + + D + P F +R Sbjct: 283 ETLRYEP--PFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR- 339 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 A + + F G C+G LAR+E + LL R Sbjct: 340 -------AGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >3OO3-A nrPDB Length = 384 Score = 35.0 bits (79), Expect = 0.067, Method: Compositional matrix adjust. Identities = 59/260 (22%), Positives = 103/260 (39%), Gaps = 59/260 (22%) Query: 257 LSRLIEKASVNRKPQ---LPQHFVDAYLDEMDQGKN-DPS------------STFSKENL 300 LSR+I ++ +R P+ L + Y + GK DP + S E L Sbjct: 157 LSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEEL 216 Query: 301 I-FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 359 + G LI+A + L A+L + +P+ ++++ +LI Sbjct: 217 AGLAEGNLIMAAEQMAAQ-LAVAVLLLVTHPDQMALLREKPELI---------------- 259 Query: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 ++ EVLR +IV D + G I G + ++ + + R P Sbjct: 260 --DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATN------RAPG- 310 Query: 420 FHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHE 476 +RF +K + F G HC+G LAR+++ + A++ RF L P E Sbjct: 311 ---DRF----DITREKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEE 363 Query: 477 LVPDLKPRLGMTLQPQPYLI 496 DL+ + G +P P+ + Sbjct: 364 ---DLRFKPG---RPAPFAV 377 >2QBO-A nrPDB Length = 421 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 64/166 (38%), Gaps = 29/166 (17%) Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363 G L++ G +T N L +++ F+A P + +LI P P A Sbjct: 243 CGLLLVVGLDTVVNFLSFSMEFLAKSP------EHRQELIERPERIP------------A 284 Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 E+LR ++V G + D G + KG ++ DE+ P H + Sbjct: 285 ACEELLRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACP--MHVD 340 Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + +K + F G CLG+HLAR E+ + L R Sbjct: 341 -------FSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRI 379 >6HQW-A nrPDB Length = 445 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 34/163 (20%), Positives = 65/163 (39%), Gaps = 29/163 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 LI+ G +TT N + + + +P+ + ++++ LI PN + Sbjct: 280 LIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLI--PNA----------------VQ 321 Query: 367 EVLRFCNIVPLGIFHAT-SEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E +R+ + PL T + D + G I G VI S + DE + +P+ +R Sbjct: 322 ECIRY--VTPLAHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDR- 378 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 + F G C+G LA +++ + + +R Sbjct: 379 -------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHER 414 >5D3U-A nrPDB Length = 427 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 67/161 (41%), Gaps = 13/161 (8%) Query: 312 TETT--TNVLRWAILFMALY-PNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368 TETT V + A++F+AL+ P G + L N + + +EV Sbjct: 249 TETTPEQTVHQLALVFIALFAPTTPGSLSSGT-LAFARNPRQVERFLADQACVDNTANEV 307 Query: 369 LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428 LR+ N + ++D + G I G T+ L S + D + P F +R +S Sbjct: 308 LRY-NASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR-PNS 365 Query: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + + + F G CL L +++ F+ ALL RF Sbjct: 366 ARHLS-------FGQGVHACLAAQLISLQLKWFYVALLNRF 399 >6HQG-A nrPDB Length = 425 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 38/172 (22%), Positives = 70/172 (40%), Gaps = 33/172 (19%) Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKM 358 NLI LI+ G +TT N + ++L + P+ ++++ LI Sbjct: 255 NLIL----LIVGGNDTTRNTISGSVLALHQNPDQDRKLRENPGLI--------------- 295 Query: 359 PYTEAVLHEVLRFCNIVPLGIFHATSE-DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 417 A++ E +R+ PL ++ D + G +I +G V S + DE+ P Sbjct: 296 ---PAMVSETIRWQ--TPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRP 350 Query: 418 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + ER + + F G C+G LA +++ + + +L RF Sbjct: 351 NDYWIER--------PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >2IAG-A nrPDB Length = 482 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 49/120 (40%), Gaps = 15/120 (12%) Query: 359 PYTEAVLHEVLRFCN---IVPLGIFHATSEDAVVRGYSIPKGTTVIT-NLYSVHFDEKYW 414 P ++VL E LR I + A R +++ +G ++ S D + + Sbjct: 317 PVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIY 376 Query: 415 RDPEVFHPERFLDSSGYFAK---------KEALVPFSLGRRHCLGEHLA--RMEMFLFFT 463 DPEVF RFL+ G K K +P+ G HCLG A ++ F+F Sbjct: 377 TDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLV 436 >2GLF-A nrPDB Length = 450 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 38/92 (41%), Gaps = 12/92 (13%) Query: 232 FPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 291 + W+ I P H LF+N + + KP+ P + L +D+ Sbjct: 125 YHWLSI-PLEIHGVLFKNDGTEIEI--------HIGDKPEDPVFTIPDLLPHLDKEDAKI 175 Query: 292 SSTFSKENLIFSVGELIIAGTE---TTTNVLR 320 S F ENL+ G + ++G E TNVL+ Sbjct: 176 SEKFKGENLMLIAGTIPLSGEEKEAVKTNVLK 207 >6BLD-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 65/161 (40%), Gaps = 28/161 (17%) Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L +AG +TT + + + +P+ + + + D +G + Sbjct: 257 LAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVE 299 Query: 367 EVLRFCNIVPLGIFHATSE-DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425 E++R+ P+ F T+ D + G I G V+ S ++DE + HPER Sbjct: 300 ELVRWAT--PVMTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAF-----CHPER- 351 Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 LD S + + G CLG HLAR ++ F LL Sbjct: 352 LDLSR--SPNPHVGFGGGGVHFCLGAHLARAQLRAIFGELL 390 >2WV5-A nrPDB Length = 214 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 19/96 (19%) Query: 124 LLNSRYGRGWVDHRRLAVNSFRYFGY-----GQKSFE----------SKILEETKFFNDA 168 L +Y + +D R + + +R F + GQ +K+ + TK F D Sbjct: 48 LFAEKYDKIMLDGRAMTDSDYRVFEFEIKVKGQDMLSDAALMVLHRGNKVRDITKHFRDT 107 Query: 169 IETYKGRPFDFKQLITNAVSNITNLIIFGERFTYED 204 KG P ++ NA ++ LI GE TY+D Sbjct: 108 ARMKKGTP--VVGVVNNA--DVGRLIFSGEALTYKD 139 >5H5M-A nrPDB Length = 381 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 21/35 (60%) Query: 162 TKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196 +K + +ETYK FD +L+T A+ NIT L F Sbjct: 206 SKTAQENMETYKNAWFDKVRLLTTALDNITTLDDF 240 >6D6R-H nrPDB Length = 296 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 16/100 (16%) Query: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE 451 + +P G +VI L + F W P H E ++ G+ A E P SL R + Sbjct: 190 HDLPCGASVI--LGNNGF---IWIYPTPEHKEE--EAGGFIANLE---PVSLADREVISR 239 Query: 452 ------HLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 L M L+ T++L + PH++ LKP + Sbjct: 240 LRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEI 279 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3DL9-A nrPDB 595 e-170 2NNH-A nrPDB 493 e-140 5W0C-A nrPDB 489 e-138 4GQS-A nrPDB 485 e-137 1N6B-A nrPDB 478 e-135 6B82-A nrPDB 469 e-132 4H1N-A nrPDB 467 e-132 3E6I-A nrPDB 466 e-131 5E0E-A nrPDB 459 e-129 5E58-A nrPDB 457 e-129 2PG7-A nrPDB 454 e-128 3IBD-A nrPDB 448 e-126 4R20-A nrPDB 420 e-118 6DWN-A nrPDB 414 e-116 2HI4-A nrPDB 414 e-116 4R1Z-A nrPDB 411 e-115 5UYS-A nrPDB 404 e-113 3TBG-A nrPDB 397 e-111 6IQ5-A nrPDB 363 e-101 5VBU-A nrPDB 360 e-100 6DA2-A nrPDB 359 2e-99 3QZ1-A nrPDB 349 1e-96 5VEU-A nrPDB 344 7e-95 5YLW-A nrPDB 337 6e-93 2WX2-A nrPDB 335 4e-92 3L4D-A nrPDB 309 2e-84 3JUS-A nrPDB 305 3e-83 2X2N-A nrPDB 303 1e-82 2VE3-A nrPDB 288 2e-78 6AYB-A nrPDB 288 3e-78 3K9V-A nrPDB 284 8e-77 4WMZ-A nrPDB 267 9e-72 6C94-A nrPDB 265 3e-71 5JLC-A nrPDB 265 4e-71 5FSA-A nrPDB 256 2e-68 6CR2-A nrPDB 236 2e-62 2W0A-A nrPDB 234 9e-62 3EL3-A nrPDB 233 1e-61 5IT1-A nrPDB 231 8e-61 3MDV-A nrPDB 228 4e-60 3ABA-A nrPDB 228 6e-60 6M7X-A nrPDB 227 8e-60 4ZGX-A nrPDB 227 1e-59 4OQS-A nrPDB 225 3e-59 4OQR-A nrPDB 223 2e-58 4GGV-A nrPDB 221 6e-58 5L94-A nrPDB 215 4e-56 2Z36-A nrPDB 214 9e-56 5OFQ-A nrPDB 213 2e-55 3MZS-A nrPDB 213 2e-55 4UBS-A nrPDB 213 2e-55 2ZBZ-A nrPDB 212 3e-55 4KPA-A nrPDB 212 4e-55 3N9Z-A nrPDB 211 5e-55 3EJB-B nrPDB 209 2e-54 4RM4-A nrPDB 207 8e-54 5VWS-A nrPDB 207 8e-54 2VZM-A nrPDB 207 9e-54 4YZR-A nrPDB 206 2e-53 1Z8P-A nrPDB 206 2e-53 5CJE-A nrPDB 205 3e-53 1ODO-A nrPDB 205 4e-53 4Z5P-A nrPDB 205 5e-53 3A50-A nrPDB 204 9e-53 5NWS-A nrPDB 204 9e-53 6GMF-A nrPDB 203 2e-52 3ABB-A nrPDB 203 2e-52 3TYW-A nrPDB 199 2e-51 5XNT-A nrPDB 199 2e-51 2Y5N-A nrPDB 197 1e-50 5YSW-A nrPDB 195 4e-50 5EX6-C nrPDB 194 5e-50 4YT3-A nrPDB 194 1e-49 1UED-A nrPDB 193 1e-49 4XE3-A nrPDB 193 2e-49 5LIE-A nrPDB 191 4e-49 4JBT-A nrPDB 191 7e-49 1EHE-A nrPDB 190 1e-48 6A7J-A nrPDB 190 1e-48 3R9C-A nrPDB 189 2e-48 3WVS-A nrPDB 189 3e-48 5Y1I-A nrPDB 189 3e-48 6FSH-A nrPDB 188 6e-48 5XW2-A nrPDB 188 8e-48 4WPZ-A nrPDB 188 8e-48 4TRI-A nrPDB 186 2e-47 6A7I-A nrPDB 186 2e-47 6CVC-A nrPDB 186 3e-47 2WM5-A nrPDB 185 3e-47 4TX3-A nrPDB 185 4e-47 5Z9I-A nrPDB 184 8e-47 4MM0-A nrPDB 184 1e-46 3P3Z-A nrPDB 183 2e-46 5FOI-A nrPDB 183 2e-46 2XKR-A nrPDB 181 7e-46 2WIO-A nrPDB 181 7e-46 6GK6-A nrPDB 181 9e-46 6B11-A nrPDB 179 3e-45 1LG9-A nrPDB 178 5e-45 5DQN-A nrPDB 177 1e-44 3S79-A nrPDB 176 3e-44 1CPT-A nrPDB 175 4e-44 6F0B-A nrPDB 173 2e-43 6M7L-A nrPDB 171 5e-43 2X9P-A nrPDB 171 6e-43 3IVY-A nrPDB 167 8e-42 3MGX-A nrPDB 167 1e-41 3A1L-A nrPDB 166 2e-41 3RWL-A nrPDB 166 3e-41 2FR7-A nrPDB 162 3e-40 2UUQ-A nrPDB 161 6e-40 5LIV-A nrPDB 160 1e-39 1UE8-A nrPDB 159 2e-39 6F88-A nrPDB 159 2e-39 2RFC-A nrPDB 157 1e-38 1Q5D-A nrPDB 157 1e-38 3TKT-A nrPDB 154 9e-38 5FYF-A nrPDB 153 2e-37 4DO1-A nrPDB 152 2e-37 6GII-A nrPDB 144 8e-35 5HIW-A nrPDB 143 2e-34 6FYJ-A nrPDB 128 4e-30 1WIY-A nrPDB 127 9e-30 5YHJ-A nrPDB 123 2e-28 6G71-A nrPDB 120 1e-27 5M0P-A nrPDB 112 4e-25 3AWQ-A nrPDB 96 4e-20 Sequences not found previously or not previously below threshold: 5XJN-A nrPDB 186 3e-47 5GWE-A nrPDB 185 3e-47 1GWI-A nrPDB 177 7e-45 4Z5Q-A nrPDB 173 1e-43 3NC3-A nrPDB 167 1e-41 1F4U-A nrPDB 161 5e-40 6HQW-A nrPDB 159 2e-39 6HQG-A nrPDB 157 1e-38 5L1U-A nrPDB 155 4e-38 4PWV-A nrPDB 154 7e-38 3SN5-A nrPDB 154 9e-38 5HH3-A nrPDB 152 2e-37 3OO3-A nrPDB 149 2e-36 6G5O-A nrPDB 146 2e-35 5H1Z-A nrPDB 146 2e-35 5DE9-A nrPDB 146 3e-35 6BLD-A nrPDB 142 4e-34 5EX8-A nrPDB 142 4e-34 6DCD-A nrPDB 139 2e-33 5HDI-A nrPDB 139 3e-33 6HQD-A nrPDB 138 6e-33 2NZA-A nrPDB 132 3e-31 3WEC-A nrPDB 130 2e-30 2WIY-A nrPDB 129 3e-30 3OFT-A nrPDB 128 6e-30 5OMS-A nrPDB 124 1e-28 4FB2-A nrPDB 123 2e-28 2IJ7-A nrPDB 122 4e-28 5KYO-A nrPDB 118 7e-27 3BUJ-A nrPDB 117 8e-27 5D3U-A nrPDB 116 2e-26 2QBO-A nrPDB 116 3e-26 2ZQJ-A nrPDB 115 5e-26 3B98-A nrPDB 110 1e-24 3NV6-A nrPDB 105 4e-23 4C9K-A nrPDB 103 2e-22 2IAG-A nrPDB 99 4e-21 2RCM-A nrPDB 77 1e-14 3DBM-A nrPDB 71 1e-12 2YJN-B nrPDB 61 1e-09 4YXC-B nrPDB 35 0.050 4YXB-D nrPDB 33 0.41 2B24-A nrPDB 32 0.68 5L9W-B nrPDB 30 1.8 3RP9-A nrPDB 30 2.8 2BKC-A nrPDB 30 3.3 4CIU-A nrPDB 29 4.5 3RFT-A nrPDB 29 4.6 3EUH-A nrPDB 28 8.1 >3DL9-A nrPDB Length = 479 Score = 595 bits (1534), Expect = e-170, Method: Composition-based stats. Identities = 470/473 (99%), Positives = 471/473 (99%) Query: 29 QLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV Sbjct: 3 KKTKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 62 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG Sbjct: 63 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 122 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ Sbjct: 123 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 182 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR Sbjct: 183 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 242 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL Sbjct: 243 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 302 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV Sbjct: 303 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 362 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC Sbjct: 363 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 422 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR Sbjct: 423 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 475 >2NNH-A nrPDB Length = 476 Score = 493 bits (1270), Expect = e-140, Method: Composition-based stats. Identities = 163/474 (34%), Positives = 266/474 (56%), Gaps = 6/474 (1%) Query: 30 LLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + K+ G PPGP LP IGN+ + S+VYG +F++ G VV Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICK--SFTNFSKVYGPVFTVYFGMNPIVV 58 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 +GY+ VKE L+ E F+ R P+ ++TK G+++S G+ W + RR ++ + R FG Sbjct: 59 FHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRWKEIRRFSLTTLRNFG 117 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 G++S E ++ EE + + K P D ++ A N+ ++F +RF Y+D +F Sbjct: 118 MGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFL 177 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 +++ F+EN + S + + N FP + G H ++ +N A+ ++ +++ + Sbjct: 178 TLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASL 237 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 P+ F+D +L +M+Q K++ S F+ ENL+ +V +L +AGTETT+ LR+ +L + Sbjct: 238 DVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLK 297 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 +P + +VQ+EID ++G + P D+ MPYT+AV+HE+ R+ ++VP G+ HA + D Sbjct: 298 HPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTK 357 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 R Y IPKGTT++ L SV D+K + +P +F P FLD +G F K + +PFS G+R C Sbjct: 358 FRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRIC 417 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHEL--VPDLKPRLGMTLQPQPYLICAER 500 GE LARME+FLF T +LQ F+L +L + G+ P Y IC Sbjct: 418 AGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >5W0C-A nrPDB Length = 477 Score = 489 bits (1259), Expect = e-138, Method: Composition-based stats. Identities = 163/465 (35%), Positives = 260/465 (55%), Gaps = 7/465 (1%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP LP IGNI + + S+VYG +F+L G VVL+GY+ VKE Sbjct: 12 LPPGPTPLPVIGNILQIGIKDISK--SLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA 69 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 L+ E F+ R PL + + G++ S G+ W + RR ++ + R FG G++S E ++ Sbjct: 70 LIDLGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIEDRV 128 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 EE + + + K P D ++ A N+ IIF +RF Y+D F +++E +EN+ Sbjct: 129 QEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENI 188 Query: 219 ELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD 278 ++ +S + + N F I G H +L +N A + ++ +++ + PQ F+D Sbjct: 189 KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID 248 Query: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338 +L +M++ K++ S F+ E+L + +L AGTETT+ LR+A+L + +P + +VQ+ Sbjct: 249 CFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQE 308 Query: 339 EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGT 398 EI+ ++G N P D+ MPYT+AV+HEV R+ +++P + HA + D R Y IPKGT Sbjct: 309 EIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGT 368 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 T++ +L SV D K + +PE+F P FLD G F K + +PFS G+R C+GE LA ME+ Sbjct: 369 TILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMEL 428 Query: 459 FLFFTALLQRFHLHFPHELVPDLKPRL---GMTLQPQPYLICAER 500 FLF T++LQ F+L + +L G P Y +C Sbjct: 429 FLFLTSILQNFNLKSLVDPK-NLDTTPVVNGFASVPPFYQLCFIP 472 >4GQS-A nrPDB Length = 477 Score = 485 bits (1247), Expect = e-137, Method: Composition-based stats. Identities = 166/465 (35%), Positives = 261/465 (56%), Gaps = 7/465 (1%) Query: 39 FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PPGP LP IGNI + + S++YG +F+L G VVL+GY+VVKE Sbjct: 12 LPPGPTPLPVIGNILQIDIKDVSK--SLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 69 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 L+ E F+ R PL + + G++ S G+ W + RR ++ + R FG G++S E ++ Sbjct: 70 LIDLGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIEDRV 128 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENV 218 EE + + + K P D ++ A N+ IIF +RF Y+D F +++E +EN+ Sbjct: 129 QEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENI 188 Query: 219 ELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD 278 + ++ + + N FP I G H +L +N A + + +++ + P+ F+D Sbjct: 189 RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 248 Query: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338 +L +M++ K + S F+ ENL+ + +L+ AGTETT+ LR+A+L + +P + +VQ+ Sbjct: 249 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 308 Query: 339 EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGT 398 EI+ ++G N P D+ MPYT+AV+HEV R+ +++P + HA + D R Y IPKGT Sbjct: 309 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 368 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 T++T+L SV D K + +PE+F P FLD G F K +PFS G+R C+GE LARME+ Sbjct: 369 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 428 Query: 459 FLFFTALLQRFHLHFPHELVPDLKPRL---GMTLQPQPYLICAER 500 FLF T +LQ F+L + DL G P Y +C Sbjct: 429 FLFLTFILQNFNLKSLIDPK-DLDTTPVVNGFASVPPFYQLCFIP 472 >1N6B-A nrPDB Length = 473 Score = 478 bits (1229), Expect = e-135, Method: Composition-based stats. Identities = 174/475 (36%), Positives = 268/475 (56%), Gaps = 11/475 (2%) Query: 30 LLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + K+ G PPGP P IGNI + A + K S+ YG +F++ LG TVV Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISK--SLTKFSECYGPVFTVYLGMKPTVV 58 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 L+GY+ VKE LV E FA R +P+ K++K G+ S + W + RR ++ + R FG Sbjct: 59 LHGYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSN-AKTWKEMRRFSLMTLRNFG 117 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 G++S E +I EE + + + P D ++ A N+ +IF RF Y+D +F Sbjct: 118 MGKRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFL 177 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 ++E ENVEL + + +YN FP + G H+ L +NA + +F+ +++ Sbjct: 178 KLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLL 237 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 P+ F+D +L +M+Q + + F+ E+L+ +V +L AGTETT+ LR+++L + Sbjct: 238 DVNNPRDFIDCFLIKMEQ---ENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLK 294 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 +P + +VQ+EI+ ++G + P D+ +MPYT+AV+HE+ RF +++P + HA + D Sbjct: 295 HPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVR 354 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 R Y IPKGT +IT+L SV DEK + +P+VF P FLD SG F K + +PFS G+R C Sbjct: 355 FRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMC 414 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL---GMTLQPQPYLICAER 500 +GE LARME+FLF T++LQ F L E DL G P Y +C Sbjct: 415 VGEGLARMELFLFLTSILQNFKLQSLVEPK-DLDITAVVNGFVSVPPSYQLCFIP 468 >6B82-A nrPDB Length = 509 Score = 469 bits (1206), Expect = e-132, Method: Composition-based stats. Identities = 155/486 (31%), Positives = 257/486 (52%), Gaps = 13/486 (2%) Query: 26 GVRQLLKQRRPMG--FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGG 83 G +Q + P G PP P LP IG++ SL + S PH++ + + YG+++SL +G Sbjct: 9 GKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSP-PHIFFQDLQKKYGDLYSLMMGS 67 Query: 84 ISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLL-NSRYGRGWVDHRRLAVN 142 +++N + KE L+ + +IFA RP +T+ G + + Y W HR++ Sbjct: 68 HKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHG 127 Query: 143 SFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTY 202 + FG G S E I E + + + D +T AV+N+ + F + Sbjct: 128 ALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKR 187 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIE 262 D +F+ M++ V+ A S L + FPW+ I P + L + ++ L + E Sbjct: 188 GDAEFESMLQYSQGIVDTVAKDS--LVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYE 245 Query: 263 KASVNRKPQLPQHFVDAYLDEMDQGKNDPSST----FSKENLIFSVGELIIAGTETTTNV 318 + V + + +DA L +N+ SST ++++++ +VGE+ AG ETTT Sbjct: 246 EHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTT 305 Query: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 L+W+I ++ P +Q ++Q+E+D +G P D+ +PY EA + EV+R + PL Sbjct: 306 LKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLL 365 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS--SGYFAKKE 436 I H +D+ V Y++ KGT V+ N++S+H DEK W++PE+F P RFL+ G Sbjct: 366 IPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSG 425 Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQPQPYL 495 + +PF G R CLGE LA+ME+FLF +LQRF L P + +PDL+ + G+ LQP+ + Sbjct: 426 SYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFK 485 Query: 496 ICAERR 501 + A+ R Sbjct: 486 VVAKVR 491 >4H1N-A nrPDB Length = 479 Score = 467 bits (1201), Expect = e-132, Method: Composition-based stats. Identities = 175/475 (36%), Positives = 265/475 (55%), Gaps = 6/475 (1%) Query: 30 LLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + K+ G PPGP LP +GN+ + L + + YG++F++ LG VV Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLL--RSFLRLREKYGDVFTVYLGSRPVVV 58 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 L G D ++E LV Q+E F+ R + + + + G++ + G W RR ++ + R FG Sbjct: 59 LCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFAN-GERWRALRRFSLATMRDFG 117 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 G++S E +I EE + + + KG D L + SNI I+FG+RF Y+D F Sbjct: 118 MGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFL 177 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 +++LF ++ L +S S ++ F G H+Q++RN + F+ + +EK Sbjct: 178 RLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATL 237 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 P P+ F+D YL M++ K+DPSS F +NLI +V L AGTETT+ LR+ L M Sbjct: 238 DPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLK 297 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 YP++ +VQKEI+ ++G + P+ DD+ KMPYT+AV+HE+ R +++P G+ H ++D Sbjct: 298 YPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQ 357 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 RGY IPK T V L S D +Y+ P F+P FLD++G + E +PFSLG+R C Sbjct: 358 FRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRIC 417 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFP-HELVPDLKPR-LGMTLQPQPYLICAERR 501 LGE +AR E+FLFFT +LQ F + P DL PR G+ P Y I R Sbjct: 418 LGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >3E6I-A nrPDB Length = 476 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 168/475 (35%), Positives = 262/475 (55%), Gaps = 7/475 (1%) Query: 30 LLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + K+ G PPGP LP IGN++ L + + +Q +G +F+L +G VV Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPK--SFTRLAQRFGPVFTLYVGSQRMVV 58 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 ++GY VKE L+ + F+ R LP F G + N+ G W D RR ++ + R +G Sbjct: 59 MHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNN--GPTWKDIRRFSLTTLRNYG 116 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 G++ ES+I E F +A+ +G+PFD LI A N+ I+F + F Y D F Sbjct: 117 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 176 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 ++ LF+EN L ++ + LYN FP G H+++ +N A V +++S +++ + Sbjct: 177 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 236 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 P P+ D L EM++ K+ ++ + + +V +L AGTETT+ LR+ +L + Sbjct: 237 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 296 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 YP I+ ++ +EID ++GP+ P+ D+ +MPY +AV+HE+ RF +VP + H + D + Sbjct: 297 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 356 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 RGY IPKGT V+ L SV +D + + DPE F PE FL+ +G F + PFS G+R C Sbjct: 357 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 416 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELV-PDLKP-RLGMTLQPQPYLICAERR 501 GE LARME+FL A+LQ F+L + DL P +G P Y +C R Sbjct: 417 AGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 471 >5E0E-A nrPDB Length = 463 Score = 459 bits (1181), Expect = e-129, Method: Composition-based stats. Identities = 162/453 (35%), Positives = 256/453 (56%), Gaps = 5/453 (1%) Query: 51 NIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRP 110 N+ + R+ + YG++F++ LG V+L G + ++E LV Q+E F+ R Sbjct: 14 NLLQMDRGG--FLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRG 71 Query: 111 CLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE 170 + + + + G++ + G W RR ++ + R FG G++S E +I EE + + Sbjct: 72 TIAVVEPIFRGYGVVFAN-GERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFR 130 Query: 171 TYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 230 +G P D L +NI I+FGERF Y+D F ++ LF ++ L +S S ++ Sbjct: 131 KSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFE 190 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 F G H+Q+ RN + D++ + +EK P P+ F+D YL M++ K++ Sbjct: 191 LFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSN 250 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 + F +NL+ SV L AGTET++ LR+ L M YP++ +VQKEID ++G + P Sbjct: 251 QHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLP 310 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 + +D+ KMPYTEAV++E+ RF +++P+G+ H ++D + RGY +PK T V L S D Sbjct: 311 TLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHD 370 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 +Y+ P+ F+P+ FLD++G K EA +PFS+G+R CLGE +AR E+FLFFT +LQ F Sbjct: 371 PQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFS 430 Query: 471 LHFPHELV-PDLKPR-LGMTLQPQPYLICAERR 501 L P DL P+ G PQ Y IC R Sbjct: 431 LSSPVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5E58-A nrPDB Length = 493 Score = 457 bits (1176), Expect = e-129, Method: Composition-based stats. Identities = 159/453 (35%), Positives = 251/453 (55%), Gaps = 5/453 (1%) Query: 51 NIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRP 110 N+ + + + YG++F++ LG V+L G + ++E LV Q+E F+ R Sbjct: 42 NLLQMDRGG--FLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRG 99 Query: 111 CLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE 170 + + + G++ S G W RR ++ + R FG G++S E +I EE + + ++ Sbjct: 100 TIAVIKPVIGDYGMIFSN-GERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQ 158 Query: 171 TYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 230 +G P D L +NI I+FGER+ Y+D F +++LF L +S S ++ Sbjct: 159 KSQGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFE 218 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 F G H+Q+ RN + D++ + +EK P P+ F+D YL M++ K++ Sbjct: 219 LFSGFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSN 278 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 + F +NL+ SV L AGTETT+ LR+ L M YP++ +VQKEID ++G + P Sbjct: 279 QHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLP 338 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 + +D+ KMPYT+AV+HE+ RF ++ P+G H ++D + RGY +PK T V L S D Sbjct: 339 TLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHD 398 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 +Y+ P F+P+ FLD++G K EA +PFS+G+R CLGE +AR E+FLFFT +LQ F Sbjct: 399 PQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFS 458 Query: 471 LHFPHELV-PDLKPR-LGMTLQPQPYLICAERR 501 + DL P+ G+ PQ Y I R Sbjct: 459 VSSSVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >2PG7-A nrPDB Length = 476 Score = 454 bits (1168), Expect = e-128, Method: Composition-based stats. Identities = 162/475 (34%), Positives = 266/475 (56%), Gaps = 6/475 (1%) Query: 30 LLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV 88 + K+ G PPGP LPFIGN L ++E + + K S+ YG +F++ LG VV Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQL--NTEQMYNSLMKISERYGPVFTIHLGPRRVVV 58 Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 L G+D V+E LV Q+E F+ R F + K G++ S G RR ++ + R FG Sbjct: 59 LCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDFG 117 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 G++ E +I EE F DA+ G D ++ VSN+ + I+FG+RF Y+D +F Sbjct: 118 VGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFL 177 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 ++ + + ++++ LY F + G QQ F+ + DF+++ +E Sbjct: 178 SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTL 237 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 P P+ F+D++L M + + +P++ F +NL+ + +L + GTET + LR+ L + Sbjct: 238 DPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMK 297 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++P+ + +D Sbjct: 298 HPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 357 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 R + +PKGT V L SV D ++ +P+ F+P+ FL+ G F K +A VPFS+G+R+C Sbjct: 358 FRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNC 417 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELV-PDLKPR-LGMTLQPQPYLICAERR 501 GE LARME+FLFFT ++Q F L D+ P+ +G P+ Y + R Sbjct: 418 FGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >3IBD-A nrPDB Length = 476 Score = 448 bits (1152), Expect = e-126, Method: Composition-based stats. Identities = 155/453 (34%), Positives = 245/453 (54%), Gaps = 5/453 (1%) Query: 51 NIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRP 110 N+ + L + + YG++F++ LG V+L G + ++E LV ++E F+ R Sbjct: 23 NLLQMDRRGLLK--SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRG 80 Query: 111 CLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE 170 + + + G++ + G W RR +V + R FG G++S E +I EE + + + Sbjct: 81 KIAMVDPFFRGYGVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELR 139 Query: 171 TYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 230 KG D L + +NI I+FG+RF Y+D +F M+ LF + L +S L+ Sbjct: 140 KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE 199 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 F G H+Q+++N + ++ +EK P P+ +D YL M++ K++ Sbjct: 200 LFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSN 259 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 S FS +NL + L AGTETT+ LR+ L M YP++ +V +EI+ ++GP+ P Sbjct: 260 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 319 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 D+ KMPYTEAV++E+ RF +++P+G+ H ++ RGY IPK T V L + D Sbjct: 320 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 379 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 Y+ P+ F+P+ FLD++G K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F Sbjct: 380 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 439 Query: 471 LHFP-HELVPDLKP-RLGMTLQPQPYLICAERR 501 + P DL P G+ P Y I R Sbjct: 440 MASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >4R20-A nrPDB Length = 486 Score = 420 bits (1079), Expect = e-118, Method: Composition-based stats. Identities = 139/447 (31%), Positives = 234/447 (52%), Gaps = 5/447 (1%) Query: 57 ASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFM 116 S+ PH+ + S YG +F L G T+V++ +V+E L+ + FA RP + Sbjct: 36 RSNLPPHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTD 95 Query: 117 KMTKMGGLL-NSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGR 175 +T+ G + + Y W +HRRL +SF FG G ++ + E + ++ +G+ Sbjct: 96 LLTQGGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQ 155 Query: 176 PFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI 235 D ++ AV+N+ ++F + D + Q +I+ V+ A L + FPW+ Sbjct: 156 SSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGG--LVDIFPWL 213 Query: 236 GILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTF 295 I P ++L ++ L + + + + P P+ +DA L +G Sbjct: 214 RIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADD-I 272 Query: 296 SKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK 355 ++++++ + E AG ETT+ L W I F+ +P +Q +VQ E+D +G + P D+ Sbjct: 273 TEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDR 332 Query: 356 CKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWR 415 +P +AVL EV+R + P+ I H +D + G+S+PKGT V+ N++++H D K+W Sbjct: 333 PHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWD 392 Query: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH 475 PE F+PERFL+ SG + + +PF G R C+GE LAR+E+FLF + LQRF P Sbjct: 393 QPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPS 452 Query: 476 EL-VPDLKPRLGMTLQPQPYLICAERR 501 E +PDL+ R G+ LQP+ Y + R Sbjct: 453 EASLPDLQGRFGVVLQPERYTVTVTPR 479 >6DWN-A nrPDB Length = 491 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 131/477 (27%), Positives = 234/477 (49%), Gaps = 21/477 (4%) Query: 30 LLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTV 87 + K+ G PPGP G P IG++ +L + PH+ + + SQ YG++ + +G V Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLGKN---PHLALSRMSQQYGDVLQIRIGSTPVV 57 Query: 88 VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNS-RYGRGWVDHRRLAVNSFRY 146 VL+G D +++ LV Q + F RP L F ++ + S G W RRLA N + Sbjct: 58 VLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 117 Query: 147 FGYGQKS-------FESKILEETKFFNDAIETYKGRP--FDFKQLITNAVSNITNLIIFG 197 F E + +E + ++ P F+ + + +V+N+ I FG Sbjct: 118 FSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFG 177 Query: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257 R+ + + ++ L + E+ S + + P + LP Y F+ Sbjct: 178 RRYDHNHQELLSLVNLNNNFGEVVGSGNP--ADFIPILRYLPNPSLNAFKDLNEKFYSFM 235 Query: 258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS--TFSKENLIFSVGELIIAGTETT 315 +++++ + + D+ ++ + + D ++ S E +I V +L AG +T Sbjct: 236 QKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTV 295 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T + W+++++ + P +Q ++Q+E+D ++G + +P D+ +PY EA + E R + V Sbjct: 296 TTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV 355 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK- 434 P I H+T+ D ++G+ IPKG V N + ++ D+K W +P F PERFL G K Sbjct: 356 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 415 Query: 435 -KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 E ++ F +G+R C+GE +AR E+FLF LLQR P + D+ P G+T++ Sbjct: 416 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 472 >2HI4-A nrPDB Length = 495 Score = 414 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 133/481 (27%), Positives = 229/481 (47%), Gaps = 20/481 (4%) Query: 25 LGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLG 82 + V + L+ R P G PP P G P +G++ +L + PH+ + + SQ YG++ + +G Sbjct: 1 MAVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN---PHLALSRMSQRYGDVLQIRIG 57 Query: 83 GISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYGRGWVDHRRLAV 141 +VL+ D +++ LV Q + F RP L +T L ++ G W RRLA Sbjct: 58 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQ 117 Query: 142 NSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRP--FDFKQLITNAVSNITN 192 N+ F E + +E K ++ P FD + +V+N+ Sbjct: 118 NALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIG 177 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV 252 + FG+ F + +++ E VE A+S + + FP + LP Q+ Sbjct: 178 AMCFGQHFPESSDEMLSLVKNTHEFVETASSGNP--LDFFPILRYLPNPALQRFKAFNQR 235 Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312 FL + +++ + + A +G + +E ++ V ++ AG Sbjct: 236 FLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGF 295 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 +T T + W+++++ P IQ ++QKE+D ++G +P D+ ++PY EA + E R Sbjct: 296 DTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHS 355 Query: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF 432 + +P I H+T+ D + G+ IPK V N + V+ D + W DP F PERFL + G Sbjct: 356 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 415 Query: 433 AKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 489 K E ++ F +G+R C+GE LA+ E+FLF LLQ+ P + DL P G+T+ Sbjct: 416 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTM 475 Query: 490 Q 490 + Sbjct: 476 K 476 >4R1Z-A nrPDB Length = 439 Score = 411 bits (1057), Expect = e-115, Method: Composition-based stats. Identities = 136/429 (31%), Positives = 225/429 (52%), Gaps = 10/429 (2%) Query: 81 LGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLL-NSRYGRGWVDHRRL 139 +G +++N + KE L+ + +IFA RP +T+ G + + Y W HR++ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 140 AVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGER 199 + FG G S E I E + + + D +T AV+N+ + F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 200 FTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSR 259 + D +F+ M++ V+ A S L + FPW+ I P L + ++ L + Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDS--LVDIFPWLQIFPNKDLTILRQCISIRDKLLQK 178 Query: 260 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST----FSKENLIFSVGELIIAGTETT 315 E+ V + + +DA L +N+ SST ++++++ +VG++ AG ETT Sbjct: 179 KYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETT 238 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T VL+W+I ++ P +Q ++Q+E+D +G P D+ +PY EA + EVLR + Sbjct: 239 TTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVS 298 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS--SGYFA 433 PL I H +D+ V Y++ KGT V+ NL+S+H D+K W++PE+F P RFL+ G Sbjct: 299 PLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCC 358 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQPQ 492 + +PF G R CLGE LA+ME+FLF +LQRF L P + +PDL+ + G+ LQP+ Sbjct: 359 PSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPK 418 Query: 493 PYLICAERR 501 + + A+ R Sbjct: 419 KFKVVAKVR 427 >5UYS-A nrPDB Length = 494 Score = 404 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 129/487 (26%), Positives = 238/487 (48%), Gaps = 19/487 (3%) Query: 25 LGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGI 84 + + K +P LP +G++ L + + + K + YG I+S+ +G Sbjct: 1 MAKKTGAK------YPKSLLSLPLVGSLPFLPRHGHMHNNFF-KLQKKYGPIYSVRMGTK 53 Query: 85 STVVLNGYDVVKECLVHQSEIFADRPCLPLFM-KMTKMGGLLNSRYGRGWVDHRRLAVNS 143 +TV++ + + KE L+ + + F+ RP + G+ + G W HRRLA+ + Sbjct: 54 TTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMAT 113 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 F F G + E I +E D + T+ G+ D + AV+N+ +LI F + Sbjct: 114 FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG 173 Query: 204 DTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEK 263 D + + ++ + S L + PW+ I P ++L + + D L++++E Sbjct: 174 DPELNVIQNYNEGIIDNLSKDS--LVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN 231 Query: 264 ASVNRKPQLPQHFVDAYL------DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTN 317 + + +D + D + G + S S +++ ++G++ AG ETTT+ Sbjct: 232 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 291 Query: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377 V++W + F+ P ++ ++ +EID +G + P+ D+ ++ EA + EVLR + P+ Sbjct: 292 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 351 Query: 378 GIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY--FAKK 435 I H + D+ + +++ KGT VI NL+++H +EK W P+ F PERFL+ +G + Sbjct: 352 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 411 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE-LVPDLKPRLGMTLQPQPY 494 + +PF G R C+GE LAR E+FL LLQRF L P + +P L+ + + Sbjct: 412 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSF 471 Query: 495 LICAERR 501 + + R Sbjct: 472 KVKIKVR 478 >3TBG-A nrPDB Length = 479 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 178/440 (40%), Positives = 246/440 (55%), Gaps = 4/440 (0%) Query: 66 MRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMG 122 + + +G++FSL L VVLNG V+E LV E ADRP +P+ + + Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ 95 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQL 182 G+ +RYG W + RR +V++ R G G+KS E + EE A + GRPF L Sbjct: 96 GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGL 155 Query: 183 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 242 + AVSN+ + G RF Y+D F +++L E ++ + + NA P + +P Sbjct: 156 LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALA 215 Query: 243 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIF 302 + L A + L E Q P+ +A+L EM++ K +P S+F+ ENL Sbjct: 216 GKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRI 275 Query: 303 SVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTE 362 V +L AG TT+ L W +L M L+P++Q +VQ+EID ++G +P D+ MPYT Sbjct: 276 VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTT 335 Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 AV+HEV RF +IVPLG+ H TS D V+G+ IPKGTT+ITNL SV DE W P FHP Sbjct: 336 AVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP 395 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDL 481 E FLD+ G+F K EA +PFS GRR CLGE LARME+FLFFT+LLQ F P + P Sbjct: 396 EHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSH 455 Query: 482 KPRLGMTLQPQPYLICAERR 501 + P PY +CA R Sbjct: 456 HGVFAFLVSPSPYELCAVPR 475 >6IQ5-A nrPDB Length = 463 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 127/457 (27%), Positives = 219/457 (47%), Gaps = 22/457 (4%) Query: 63 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 122 H+ + ++ YG++F + LG VVLNG + + LV Q FADRP F ++ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQ----KSFESKILEETKFFNDAI--ETYKGRP 176 + Y W RR A + R F Q + E +L E + + + G Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 177 FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIG 236 D + L AV+N+ + + FG R++++D +F+ ++ E + S L + PW+ Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGS--LVDVMPWLQ 181 Query: 237 ILPFG------KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG--- 287 P + +QL RN + L + + R P+ +DA++ ++ Sbjct: 182 YFPNPVRTVFREFEQLNRNFSNF--ILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 288 -KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGP 346 + + EN+ ++ ++ A +T + L+W +L YP++Q +VQ E+D ++G Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 347 NGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYS 406 + P D+ +PY A L+E +RF + VP+ I HAT+ + V GY IPK T V N +S Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 407 VHFDEKYWRDPEVFHPERFLDSSGYFAKK--EALVPFSLGRRHCLGEHLARMEMFLFFTA 464 V+ D W +PE F P RFLD G K ++ FS+G+R C+GE L++M++FLF + Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 465 LLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 L + + G+T++P+ + + R Sbjct: 420 LAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >5VBU-A nrPDB Length = 476 Score = 360 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 125/484 (25%), Positives = 227/484 (46%), Gaps = 26/484 (5%) Query: 25 LGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGI 84 + + K + P PG F+ ++ +LP +Y+ +Q +G I+ L LG Sbjct: 1 MAKKTSSKGKLP-PLAPG-----FL-HLLQ----PDLP-IYLLGLTQKFGPIYRLHLGLQ 48 Query: 85 STVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLN-SRYGRGWVDHRRLAVNS 143 VVLN ++E +V + FA RP + +++ L+ Y W H++L ++ Sbjct: 49 DVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSA 108 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 + S E + + T+ F + + G P ++ + +I + FG++ + Sbjct: 109 LLLGI--RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-D 165 Query: 204 DTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEK 263 D + E ++ + S+ + + P++ P ++L + + + + Sbjct: 166 DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQ 225 Query: 264 ASVNRKPQLPQHFVDAYLDEMDQGKNDPSS-TFSKENLIFSVGELIIAGTETTTNVLRWA 322 + + +D L + Q + S + ++ + +L+I GTETT N L WA Sbjct: 226 HKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWA 285 Query: 323 ILFMALYPNIQGQVQKEIDLIMGP---NGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGI 379 ++F+ +P IQ ++Q+E+D +GP + + + D+ ++P A + EVLR +VPL + Sbjct: 286 VVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLAL 345 Query: 380 FHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALV 439 H T+ + + GY IP+GT +I NL H DE W P F P+RFL+ K + Sbjct: 346 PHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRAL 401 Query: 440 PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLK--PRLGMTLQPQPYLIC 497 F G R CLGE LAR+E+F+ T LLQ F L + +P L+ P + L+ QP+ + Sbjct: 402 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 461 Query: 498 AERR 501 + R Sbjct: 462 LQPR 465 >6DA2-A nrPDB Length = 487 Score = 359 bits (920), Expect = 2e-99, Method: Composition-based stats. Identities = 117/469 (24%), Positives = 196/469 (41%), Gaps = 19/469 (4%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100 PGP LPF+GNI S + + + YG+++ G + + D++K LV Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECH---KKYGKVWGFYDGQQPVLAITDPDMIKTVLV 75 Query: 101 HQS-EIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKIL 159 + +F +R F + M ++ W R L +F K I Sbjct: 76 KECYSVFTNRR---PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL--KEMVPIIA 130 Query: 160 EETKFFNDAI--ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217 + + E G+P K + ++ FG + +E + Sbjct: 131 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL 190 Query: 218 VELAASASVFL-YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 + FL FP++ +P + + V +FL + +++ +R +H Sbjct: 191 LRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHR 248 Query: 277 VD---AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQ 333 VD +D + + + S L+ I AG ETT++VL + + +A +P++Q Sbjct: 249 VDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQ 308 Query: 334 GQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYS 393 ++Q+EID ++ P++D +M Y + V++E LR I + + +D + G Sbjct: 309 QKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMF 367 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHL 453 IPKG V+ Y++H D KYW +PE F PERF + PF G R+C+G Sbjct: 368 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 427 Query: 454 ARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501 A M M L +LQ F E LK LG LQP+ P ++ E R Sbjct: 428 ALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >3QZ1-A nrPDB Length = 496 Score = 349 bits (896), Expect = 1e-96, Method: Composition-based stats. Identities = 120/467 (25%), Positives = 218/467 (46%), Gaps = 22/467 (4%) Query: 43 PPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQ 102 PP +P ++ LP +++ +Q G ++ L LG VVLN ++E ++ + Sbjct: 31 PPLVPGFLHLLQ----PNLP-IHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRK 85 Query: 103 SEIFADRPCLPLFMKMTKMGGLLN-SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEE 161 FA RP +P + +++ ++ Y W H++L ++ + S E + + Sbjct: 86 WVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLG--TRSSMEPWVDQL 143 Query: 162 TKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELA 221 T+ F + + G P ++ + +I + FG + EDT + + ++ Sbjct: 144 TQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNK---EDTLVHAFHDCVQDLMKTW 200 Query: 222 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 281 S+ + + P++ P +L + + + + + + + D L Sbjct: 201 DHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYML 260 Query: 282 DEMDQGKNDPS-STFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEI 340 + + + + + ++ SV +L I GTETT + L WA+ F+ +P IQ ++Q+E+ Sbjct: 261 QGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEEL 320 Query: 341 DLIMGPNG---KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKG 397 D +GP + ++ D+ ++P A + EVLR +VPL + H T+ + + GY IP+G Sbjct: 321 DRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEG 380 Query: 398 TTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 VI NL H DE W P F P+RFL+ + + F G R CLGE LAR+E Sbjct: 381 MVVIPNLQGAHLDETVWEQPHEFRPDRFLEP----GANPSALAFGCGARVCLGESLARLE 436 Query: 458 MFLFFTALLQRFHLHFPHE-LVPDLKPR--LGMTLQPQPYLICAERR 501 +F+ LLQ F L P +P L+P G+ L+ QP+ + + R Sbjct: 437 LFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR 483 >5VEU-A nrPDB Length = 480 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 114/469 (24%), Positives = 196/469 (41%), Gaps = 20/469 (4%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100 PGP LP +GN+ S + YG+++ G + + + DV++ LV Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTEC---YKKYGKMWGTYEGQLPVLAITDPDVIRTVLV 74 Query: 101 HQS-EIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKIL 159 + +F +R L + M ++ W R L +F K I Sbjct: 75 KECYSVFTNRRSL---GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL--KEMFPIIA 129 Query: 160 EETKFFNDAI--ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217 + + E KG+P K + ++ FG + +E + Sbjct: 130 QYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF 189 Query: 218 VELAASASVFL-YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLI---EKASVNRKPQLP 273 ++ +FL FP++ + + LF + +FLS+ + +K+ +N K + Sbjct: 190 LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHR 247 Query: 274 QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQ 333 F+ +D + + + S L I AG ETT++VL + + +A +P++Q Sbjct: 248 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 307 Query: 334 GQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYS 393 ++QKEID ++ P++D +M Y + V++E LR + + + +D + G Sbjct: 308 QKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVF 366 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHL 453 IPKG+ V+ Y++H D KYW +PE F PERF PF G R+C+G Sbjct: 367 IPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRF 425 Query: 454 ARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501 A M M L +LQ F E LK LQP+ P ++ + R Sbjct: 426 ALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 474 >5YLW-A nrPDB Length = 495 Score = 337 bits (865), Expect = 6e-93, Method: Composition-based stats. Identities = 113/471 (23%), Positives = 195/471 (41%), Gaps = 24/471 (5%) Query: 18 LFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIF 77 L L F L RR PPGP P +GN+ L A+ PH K S+ YG + Sbjct: 7 LAALFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGAN---PHQVFAKLSKRYGPLM 63 Query: 78 SLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG-GLLNSRYGRGWVDH 136 S+ LG + TV+++ ++ KE L ++F+ R + W D Sbjct: 64 SIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVASEWRDM 123 Query: 137 RRLAVNSFRYFGYGQKSFESKI---LEETKFFNDAIETYK--GRPFDFKQLITNAVSNIT 191 R++ + +S E+ ++ + D ++ GR D ++ N+ Sbjct: 124 RKICKEQM----FSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLM 179 Query: 192 NLIIFGERFTYEDT----DFQHMIELFSENVELAASASVF-LYNAFPWIGILPFGKHQQL 246 + +F + T D+ +F+ +IE + V + A F + F G+ Sbjct: 180 SATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADV-FF 238 Query: 247 FRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGE 306 + A + +L+ +E N F++ +D + + + + Sbjct: 239 GKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQA----NEFKLKTHHFTHLMLD 294 Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L + G++T T + WA+ + + P+ +++ E+ + G K+PY +AV+ Sbjct: 295 LFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIK 354 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 EV+R PL + D V GY IPKGT ++ N Y++ D W DPE F PERFL Sbjct: 355 EVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFL 414 Query: 427 DSSGYFAKKEA-LVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476 D+ F ++ L+PF GRR C G LA + + L+ F + Sbjct: 415 DNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDD 465 >2WX2-A nrPDB Length = 473 Score = 335 bits (858), Expect = 4e-92, Method: Composition-based stats. Identities = 82/460 (17%), Positives = 163/460 (35%), Gaps = 25/460 (5%) Query: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYM-RKQSQVYGEIFSLDLGGISTVVLN 90 RP P P +PF+G+I + P +M R + + +F++ +GG ++ Sbjct: 11 NTTRPTDPPVYPVTVPFLGHIVQFGKN---PLEFMQRCKRDLKSGVFTISIGGQRVTIVG 67 Query: 91 GYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYG 150 ++EI + R + + G + Y R + Sbjct: 68 DPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQL-NFLAEELTIAKF- 125 Query: 151 QKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM 210 ++F I E + F + + + N +FGE + + +H Sbjct: 126 -QNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLR-KRLNARHF 183 Query: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 +L S+ A+VF+ PW+ LP + + A + L +I + ++ Sbjct: 184 AQLLSKMESSLIPAAVFM----PWLLRLPLPQSARCREARAELQKILGEII--VAREKEE 237 Query: 271 QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL-- 328 + L + + + S + + + AG T+T W++L + Sbjct: 238 ASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPK 297 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 ++ KEID + D +MP+ E + E +R + L + + Sbjct: 298 NKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAEVK 354 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 V Y +PKG + + H DE+ + +P ++ PER G A + F G C Sbjct: 355 VGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDG------AFIGFGAGVHKC 408 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT 488 +G+ A +++ + + + VPD + Sbjct: 409 IGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVV 448 >3L4D-A nrPDB Length = 453 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 82/453 (18%), Positives = 160/453 (35%), Gaps = 25/453 (5%) Query: 39 FPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKE 97 PP G PF+G+I P +M K + YG IF++++ G V+ + Sbjct: 4 LPPVVHGTTPFVGHIIQFGKD---PLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSK 60 Query: 98 CLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 ++EI + R + + G + Y R + ++F Sbjct: 61 FFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQL-NFLAEELTVAKF--QNFAPS 117 Query: 158 ILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217 I E + F A + + + N +FGE + D + +L ++ Sbjct: 118 IQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLR-KRLDARQFAQLLAKM 176 Query: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277 A+VFL PWI LP + + A + D LS +I + ++ Sbjct: 177 ESCLIPAAVFL----PWILKLPLPQSYRCRDARAELQDILSEII--IAREKEEAQKDTNT 230 Query: 278 DAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA--LYPNIQGQ 335 L + + S+ + + + AG T+T W++L + + Sbjct: 231 SDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAK 290 Query: 336 VQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIP 395 + +EID + +MP+ E E +R + + + + V Y +P Sbjct: 291 LHQEIDEFPAQLNYDNV--MEEMPFAEQCARESIRRDPPL-VMLMRKVLKPVQVGKYVVP 347 Query: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLAR 455 +G + + H DE+ + +P ++PER + A F G C+GE Sbjct: 348 EGDIIACSPLLSHQDEEAFPNPREWNPERNMK-----LVDGAFCGFGAGVHKCIGEKFGL 402 Query: 456 MEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT 488 +++ +L+ + +P+ + Sbjct: 403 LQVKTVLATVLRDYDFELLG-PLPEPNYHTMVV 434 >3JUS-A nrPDB Length = 461 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 92/481 (19%), Positives = 177/481 (36%), Gaps = 37/481 (7%) Query: 30 LLKQRRPMGFPPGP---PGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGIST 86 + K+ P G P +PF+G+ + S P ++ + YG +FS + G + Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFGKS---PIEFLENAYEKYGPVFSFTMVGKTF 57 Query: 87 VVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRY 146 L G D ++E G+ +++ +++ + Sbjct: 58 TYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNI 117 Query: 147 FGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTD 206 + Q S I +ETK + ++ + N ++ LII Sbjct: 118 AHFKQHV--SIIEKETKEYFESWGESGEK---------NVFEALSELIILTASHC----- 161 Query: 207 FQHMIELFSENVELAASASVFLYNAFP---WI--GILPFGKHQQLFRNAAVVYDFLSRLI 261 H E+ S+ E A L F W+ G LP ++ R + D + I Sbjct: 162 -LHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAI 220 Query: 262 EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRW 321 +K + Q +D L + + + + + L++AG T++ W Sbjct: 221 QKRRQS------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAW 274 Query: 322 AILFMALYPNIQGQVQKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNIVPLGIF 380 F+A +Q + E + G N P ++D + + + E LR + + + Sbjct: 275 MGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMI-MM 333 Query: 381 HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVP 440 V GY+IP G V + + W + F+P+R+L + +K A VP Sbjct: 334 RMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVP 393 Query: 441 FSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAER 500 F GR C+GE+ A +++ ++ +L+ + P + + P+ +I +R Sbjct: 394 FGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMI-HTPENPVIRYKR 452 Query: 501 R 501 R Sbjct: 453 R 453 >2X2N-A nrPDB Length = 475 Score = 303 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 77/459 (16%), Positives = 153/459 (33%), Gaps = 23/459 (5%) Query: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG 91 RP P P +P +G+I S ++Q + IF++++ G ++ Sbjct: 11 NVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLK--SGIFTINIVGKRVTIVGD 68 Query: 92 YDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQ 151 + ++E+ + R + + G + Y R + Sbjct: 69 PHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQL-NFLAEELTIAKF-- 125 Query: 152 KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211 ++F I E + F A + + + + N +FGE + D + Sbjct: 126 QNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLR-KRLDARRFA 184 Query: 212 ELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQ 271 +L ++ A+VFL LP + + + LS +I Sbjct: 185 QLLAKMESSLIPAAVFLPIL----LKLPLPQSARCHEARTELQKILSEIIIARKA--AAV 238 Query: 272 LPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPN 331 L + + S + + + AG T++ W++L + N Sbjct: 239 NKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPAN 298 Query: 332 I--QGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV 389 + ++KEI+ + D +MP+ E E +R + L + D V Sbjct: 299 VKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMADVKV 355 Query: 390 RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCL 449 Y +PKG + + H DE+ + +P + PER G A + F G C+ Sbjct: 356 GSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEG------AFIGFGAGVHKCI 409 Query: 450 GEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT 488 G+ +++ + + + VPD + Sbjct: 410 GQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVV 448 >2VE3-A nrPDB Length = 444 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 114/458 (24%), Positives = 192/458 (41%), Gaps = 37/458 (8%) Query: 37 MGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVK 96 + PPG GLP++G + + + +K+ Q +G IF L G + + ++G + Sbjct: 11 LPIPPGDFGLPWLGETLNFLNDGD----FGKKRQQQFGPIFKTRLFGKNVIFISGALANR 66 Query: 97 ECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFES 156 + E F + PL ++ L ++ G R++ +F ++ +S Sbjct: 67 FLFTKEQETF--QATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFL-----PRTLDS 119 Query: 157 KILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSE 216 + + +E + G+ N V L R T++ M E S+ Sbjct: 120 YLPKMDGIVQGYLEQW-GK--------ANEVIWYPQL----RRMTFDVAATLFMGEKVSQ 166 Query: 217 NVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 N +L ++ F LP + R A++ L ++I+ + Sbjct: 167 NPQLFPWFETYIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSE----- 221 Query: 277 VDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336 + L + ++D + S L + L+ AG ET T+ L L + + +I+ +V Sbjct: 222 -EDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERV 280 Query: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396 ++E + + + + + + KMPY + VL EVLR V G F +D +G+ PK Sbjct: 281 RQEQNKLQ-LSQELTAETLKKMPYLDQVLQEVLRLIPPV-GGGFRELIQDCQFQGFHFPK 338 Query: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERF-LDSSGYFAKKEALVPFSLGRRHCLGEHLAR 455 G V + H D + DPE F PERF D S A VPF G R CLG+ AR Sbjct: 339 GWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFAR 398 Query: 456 MEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQP 493 +EM LF T L+Q+F L+P L +T P+P Sbjct: 399 LEMKLFATRLIQQFDW----TLLPGQNLELVVTPSPRP 432 >6AYB-A nrPDB Length = 466 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 90/483 (18%), Positives = 177/483 (36%), Gaps = 37/483 (7%) Query: 30 LLKQRRPMG-FPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTV 87 + K+ G PP P L P++G+ S A + P ++ S+ YG++F+ + G Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFAKN---PVQFIIDNSKKYGDVFTATILGKEMT 57 Query: 88 VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRY- 146 LN ++ + R + G + ++ ++ + + Sbjct: 58 FLNHPKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTA 117 Query: 147 -FGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDT 205 F FE +I + K D +L+ + + + + G D Sbjct: 118 RFRVFVDIFEDEIAHKVKEL------GPEGTVDVAELMADLIIFTASRCLLG------DE 165 Query: 206 DFQHMIEL----FSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLI 261 Q++ E +++ S F Y + P + + V + L+ Sbjct: 166 VRQYLSEKNLGKLYHDIDDGISPLSFFYPSLP---------APKRDKARKAVGEIFQELL 216 Query: 262 EKASVNRKPQLPQHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNV 318 +K K + + +D + K + + I + + AG T++ Sbjct: 217 DKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSIT 276 Query: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 W ++ + + +V+KE + IMG + +D KM Y EA + E LR + + Sbjct: 277 SSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IM 335 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438 I + Y IPKG ++ + + +P+VF PER + + K Sbjct: 336 IMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGA 395 Query: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICA 498 VPF GR C+GE+ A +++ + LL+ F + + +PD + P + Sbjct: 396 VPFGAGRHKCIGENFALLQVKSIISILLRYFDMEY-IGKIPDPSYTSLVVGPSPPTRMRY 454 Query: 499 ERR 501 + R Sbjct: 455 KLR 457 >3K9V-A nrPDB Length = 482 Score = 284 bits (726), Expect = 8e-77, Method: Composition-based stats. Identities = 102/473 (21%), Positives = 185/473 (39%), Gaps = 29/473 (6%) Query: 41 PGPPGLPFIGNIYSLAASSELP--HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PGP P +G++ + L H + + + YG+IF + LG +V L + E Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRY---GRGWVDHRRLAVNSFRYFGYGQKSFE 155 L R + + G+ W R K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK-LD 144 Query: 156 SKILEETKFFN---DAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIE 212 KI E F D + +GR D + L+++ +RF + + Sbjct: 145 KKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEAL 204 Query: 213 LFSENVELAASASVFLYNAFPWIGILPFGKHQQL----FRNAAVVYDFLSRLIEKASVNR 268 F +A + + F + + P H++L ++ + +D + + ++ NR Sbjct: 205 TF-------ITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNR 257 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 + Q +L ++ Q SK+ L +V EL +A ETT N L W + ++ Sbjct: 258 LQRYSQQPGADFLCDIYQQ-----DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 312 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 P Q ++ +E+ ++ N P +D MPY +A L E +R VP + V Sbjct: 313 NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTV 371 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 + Y++PKGT + N + E + D F PER+L A +PF +G+R C Sbjct: 372 LGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-NPFAHLPFGIGKRMC 430 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 +G LA +++ L ++Q++ + ++ LG+ + + I R Sbjct: 431 IGRRLAELQLHLALCWIIQKYDIVATDNEPVEM-LHLGILVPSRELPIAFRPR 482 >4WMZ-A nrPDB Length = 539 Score = 267 bits (682), Expect = 9e-72, Method: Composition-based stats. Identities = 85/494 (17%), Positives = 174/494 (35%), Gaps = 47/494 (9%) Query: 35 RPMGFPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYD 93 PP P++G+ P+ + + + YG+IFS L G V G Sbjct: 51 LRKDRPPLVFYWIPWVGSAVVYGMK---PYEFFEECQKKYGDIFSFVLLGRVMTVYLGPK 107 Query: 94 VVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKS 153 + + + G++ ++ ++ + KS Sbjct: 108 GHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALT--KEAFKS 165 Query: 154 FESKILEET-KFFND----AIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE-DTDF 207 + I EE K+F D + D + + G+ + DTDF Sbjct: 166 YVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDF 225 Query: 208 QHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVN 267 ++ +++ + F++ LP +++ + LI++ N Sbjct: 226 AYL----YSDLDKGFTPINFVFPN------LPLEHYRKRDHAQKAISGTYMSLIKERRKN 275 Query: 268 RKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327 Q + +D+ M + + + + +++ G T+ W +L +A Sbjct: 276 NDIQ-DRDLIDSL---MKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLA 331 Query: 328 LYPNIQGQVQKEIDLIM-GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSED 386 P++Q ++ +E ++ G + ++D +MP + E LR + + +F +D Sbjct: 332 ERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSLFRKVMKD 390 Query: 387 AVV--RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF------------ 432 V Y IP G V+ + H ++Y+ + F+ R+ + S Sbjct: 391 MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG 450 Query: 433 ----AKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGM 487 +PF GR C+GEH A ++ + + ++ H+P + VP + Sbjct: 451 AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMV 510 Query: 488 TLQPQPYLICAERR 501 TL P I E+R Sbjct: 511 TLPTGPAKIIWEKR 524 >6C94-A nrPDB Length = 497 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 102/454 (22%), Positives = 178/454 (39%), Gaps = 31/454 (6%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYG-EIFSLDLGGISTVVLNGYDVVKECL 99 PGPP G+ + + L V Q Y ++ G + + D K + Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIG--FLNIYEPDYAK-AV 81 Query: 100 VHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKIL 159 + + P + F GLL G W HR+L F Y K + + Sbjct: 82 YSRGD--PKAPDVYDFFLQWIGKGLLVLD-GPKWFQHRKLLTPGFHYDVL--KPYVAIFA 136 Query: 160 EETKFFNDAIE--TYKGRPFDFKQLITNAVSNITNLIIFGER---FTYEDTDF----QHM 210 + T+ + E +G+ FD + + + FG+ + D+ + + Sbjct: 137 DSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSEL 196 Query: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 L + ++ + F+Y W+ P G ++ R +D R+I + + Sbjct: 197 TLLMQQRIDSFQYHNDFIY----WL--TPHG--RRFLRACRAAHDHTDRVIRQRKAALQD 248 Query: 271 QLPQHFVD-----AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILF 325 + + + +LD + + + S +L V + G +TTT+ + W + Sbjct: 249 EKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYC 308 Query: 326 MALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSE 385 MALYP Q + ++E+ I+G W+D KM Y + E R VP + Sbjct: 309 MALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKP 368 Query: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR 445 + V G S+P G+ + ++Y++H + W DPEVF P RF + A +PFS G Sbjct: 369 VSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGP 428 Query: 446 RHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479 R+C+G+ A EM + L RF +P Sbjct: 429 RNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLP 462 >5JLC-A nrPDB Length = 515 Score = 265 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 77/516 (14%), Positives = 169/516 (32%), Gaps = 55/516 (10%) Query: 18 LFLLLFALGVRQLLKQRRPMGFPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEI 76 + L F + L PP P++G+ P+ + + YG+I Sbjct: 16 MVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTK---PYEFFEDCQKKYGDI 72 Query: 77 FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136 FS L G V G + + + G++ ++ Sbjct: 73 FSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQ 132 Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKG--------RPFDFKQLITNAVS 188 ++ + +++F + + K D Sbjct: 133 KKFVKGALT-----KEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTI 187 Query: 189 NITNLIIFGERF-TYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLF 247 + + G+ DTDF ++ +++ + F++ LP +++ Sbjct: 188 FTASRSLLGKEMRDKLDTDFAYL----YSDLDKGFTPINFVFPN------LPLEHYRKRD 237 Query: 248 RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307 + LI++ Q + +D M + + + + + + Sbjct: 238 HAQQAISGTYMSLIKERREKNDIQN-RDLIDEL---MKNSTYKDGTKMTDQEIANLLIGV 293 Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN-GKPSWDDKCKMPYTEAVLH 366 ++ G T+ W +L +A P++Q ++ +E ++ + + ++DD MP ++ Sbjct: 294 LMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIK 353 Query: 367 EVLRFCNIVPLGIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPER 424 E LR + + +F D + Y +P+ V+ + H E+++ P F+ R Sbjct: 354 ETLRLHHPL-HSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHR 412 Query: 425 FLDSSGYF-----------------AKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 + + +PF GR C+GE A ++ + + ++ Sbjct: 413 WDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIR 472 Query: 468 RFHLHFPH--ELVPDLKPRLGMTLQPQPYLICAERR 501 +P E VP +TL P I E+R Sbjct: 473 TMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKR 508 >5FSA-A nrPDB Length = 490 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 79/490 (16%), Positives = 164/490 (33%), Gaps = 42/490 (8%) Query: 40 PPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PP P+ G+ S P+ + Q YG++FS L G V G + Sbjct: 6 PPLVFYWIPWFGSAASYGQ---QPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 62 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 + + G++ ++ ++ A + + + + KI Sbjct: 63 FNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKR--YVPKI 120 Query: 159 LEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIE-LFSEN 217 EE N + + + + N + + IF + + + + + F++ Sbjct: 121 REE--ILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQL 178 Query: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277 + FP LP + + + + I+ + + Sbjct: 179 YSDLDKGFTPINFVFP---NLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLI 235 Query: 278 DAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQ 337 D+ L + + + + +++ G T+ + W +L + P++Q + Sbjct: 236 DSLLIH---STYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIY 292 Query: 338 KEIDLIM----GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV--RG 391 +E+ ++ G +++D K+P + E LR + IF + + Sbjct: 293 QEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFRKVTNPLRIPETN 351 Query: 392 YSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG--------------------Y 431 Y +PKG V+ + H E+Y+ +PE F P R+ ++ Sbjct: 352 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 411 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQP 491 +PF GR C+GE A +++ T + VPD + L Sbjct: 412 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 471 Query: 492 QPYLICAERR 501 +P I E+R Sbjct: 472 EPAEIIWEKR 481 >6CR2-A nrPDB Length = 477 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 80/486 (16%), Positives = 170/486 (34%), Gaps = 43/486 (8%) Query: 40 PPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKEC 98 PP PFIG+ S P+ + YG+IF+ L G T V G Sbjct: 6 PPVVFHWFPFIGSTISYGID---PYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFI 62 Query: 99 LVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKI 158 L + ++ ++ ++ +S+ I Sbjct: 63 LNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDAL--RSYVPLI 120 Query: 159 LEETKFFNDAIETYKG--RPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSE 216 +E + F ++G FD + I + + G+ + F Sbjct: 121 TDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSK---FDSTFAELYH 177 Query: 217 NVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 N+++ + F+ PW P +++ + + +I+ + + Sbjct: 178 NLDMGFAPINFM---LPWA---PLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDM 231 Query: 277 VDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336 V + + + + E + + L++AG ++++ W +L +A P+I ++ Sbjct: 232 VWNLMSCVYK----NGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEEL 287 Query: 337 QKEIDLIMGPNGKP-SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG--YS 393 +E ++G + P ++D+ K+ V+ E LR + I A V G Y Sbjct: 288 YQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIRAVKNPMAVDGTSYV 346 Query: 394 IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE----------------A 437 IP V+++ E+++ +P ++P R+ ++ A+ + Sbjct: 347 IPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSP 406 Query: 438 LVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH--ELVPDLKPRLGMTLQPQPYL 495 +PF GR C+GE A +++ L++ F + +PD + Sbjct: 407 YLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSF 466 Query: 496 ICAERR 501 + E+R Sbjct: 467 VEFEKR 472 >2W0A-A nrPDB Length = 455 Score = 234 bits (596), Expect = 9e-62, Method: Composition-based stats. Identities = 72/457 (15%), Positives = 153/457 (33%), Gaps = 30/457 (6%) Query: 50 GNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADR 109 G++ P M++ G++ + L G V+L+G + + Sbjct: 17 GHLEEFRTD---PIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQA 73 Query: 110 PCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI 169 P + + ++ + + N+ G K + I ++ + Sbjct: 74 KAYPFMTPIFGEAVVFDASP----ERRKEMLHNA-ALRGEQMKGHAATIEDQVRRMIADW 128 Query: 170 ETYKGRPFDFKQLITNAVSNITNLIIFGERF-TYEDTDFQHMIELFSENVELAASASVFL 228 + D ++ + G++F D F + + A Sbjct: 129 --GEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDP-- 184 Query: 229 YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288 LP ++ + ++ ++ N LD + K Sbjct: 185 --------YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSD---RDMLDVLIAVK 233 Query: 289 NDPSST-FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 + + FS + + ++ AG T++ W ++ + + + V E+D + G Sbjct: 234 AETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDG 293 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 S+ ++P E VL E LR + + + + V+G+ I +G V + Sbjct: 294 RSVSFHALRQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAASPAIS 352 Query: 408 HFDEKYWRDPEVFHPERFLDSS-GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 + + + DP F P R+ + +PF GR C+G A M++ F+ LL Sbjct: 353 NRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLL 412 Query: 467 QRFHLHF--PHELVPDLKPRLGMTLQPQPYLICAERR 501 + + P E + ++ + L QP + RR Sbjct: 413 REYEFEMAQPPESYRNDHSKMVVQLA-QPAAVRYRRR 448 >3EL3-A nrPDB Length = 467 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 85/465 (18%), Positives = 178/465 (38%), Gaps = 25/465 (5%) Query: 37 MGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVK 96 P G+P +G+ + LA P +M + +G++ + LG + + + + Sbjct: 22 REPPVAGGGVPLLGHGWRLARD---PLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPE-LT 76 Query: 97 ECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFES 156 L + P + G+ + G RR +FR ++ Sbjct: 77 GALALNPDYHIAGPLWESLEGLLGKEGVATAN-GPLHRRQRRTIQPAFRLDAIP--AYGP 133 Query: 157 KILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSE 216 + EE + + G+ D + + R Y D + + + Sbjct: 134 IMEEEAHALTERWQ--PGKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALAT 189 Query: 217 NVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 + + LP +++ A ++ + +I + + + Sbjct: 190 VFRGM---YRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKP----- 241 Query: 277 VDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336 D L + + K+D ++ + V ++ G+ET + + W + +A +P ++ Sbjct: 242 -DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRI 300 Query: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396 + E++ + G +++D K+ +T V+ E +R V + A +E + + GY IP Sbjct: 301 RDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE-SELGGYRIPA 358 Query: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456 G +I + Y++ D K + D F P+R+L K A+ PFS G+R C +H + Sbjct: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 Query: 457 EMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 ++ L AL ++ + R+G+TL+P L+ R Sbjct: 419 QLTLITAALATKYRFE--QVAGSNDAVRVGITLRPHDLLVRPVAR 461 >5IT1-A nrPDB Length = 399 Score = 231 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 84/406 (20%), Positives = 138/406 (33%), Gaps = 67/406 (16%) Query: 83 GISTVVLNGYDVVKECLVH----QSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR 138 G ++ GY+ V+ L A + + G LL D R+ Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQD-APEHTDDRK 100 Query: 139 LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGE 198 L F ++ I DAIE +G P D + N V ++ +FG Sbjct: 101 LLAKEFTVRRM--QALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANPVPSMVISDLFGV 157 Query: 199 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 258 +FQ + E + AA+ + L Sbjct: 158 PAE-RRAEFQEIAEAMMRVDQDAAATEA----------------------AGMRLGGLLY 194 Query: 259 RLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNV 318 +L+++ N L + DP L+ + G L+IA +TT + Sbjct: 195 QLVQERRANPGDDLISALI---------TTEDPDGVIDDMFLMNAAGTLLIAAHDTTACM 245 Query: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 + + P+ +QK+ LI + E+LR+ I G Sbjct: 246 IGLGTALLLDRPDQLALLQKDPSLI------------------GNAVEELLRYLTIGQFG 287 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438 ++D + G I KG V+T+L S FD + DPE F R + Sbjct: 288 AERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR---------RPAPH 338 Query: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR 484 + F G C+G+ LAR+E+ + F L +RF + V +L+ R Sbjct: 339 LAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFR 384 >3MDV-A nrPDB Length = 456 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 88/442 (19%), Positives = 175/442 (39%), Gaps = 25/442 (5%) Query: 66 MRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECL--VHQSEIFAD-RPCLPLFMKMTKMG 122 ++ YG + +++ ++V++ + VK+ L ++ R +F + Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 75 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGR--PFDFK 180 GL++ W RR+ +F S E+ + + +E P + Sbjct: 76 GLVSECNYERWHKQRRVIDLAFSRSSLV--SLMETFNEKAEQLVEILEAKADGQTPVSMQ 133 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 ++T +I FG E + + S+ V+L N Sbjct: 134 DMLTYTAMDILAKAAFG----METSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKR 189 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASV--NRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKE 298 + +++ + + +++ R ++P + L + ++D Sbjct: 190 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEG------ 243 Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKM 358 L+ + IAG ET+ N L + ++ ++ P I ++Q E+D ++G ++D ++ Sbjct: 244 -LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 302 Query: 359 PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPE 418 Y VL E LR G F E+ ++ G +P T ++ + Y + + Y+ DP Sbjct: 303 QYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPL 361 Query: 419 VFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478 F+P+RF G + PFSLG R C+G+ A+ME+ + LLQR Sbjct: 362 TFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR 419 Query: 479 PDLKPRLGMTLQPQPYLICAER 500 L+ + TL+P ++C R Sbjct: 420 FGLQEQA--TLKPLDPVLCTLR 439 >3ABA-A nrPDB Length = 403 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 79/411 (19%), Positives = 144/411 (35%), Gaps = 77/411 (18%) Query: 83 GISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG---WVDH--- 136 G ++ GY+ V+ L + F+ + + + G++ + GRG W D Sbjct: 42 GHEAWLVTGYEEVRALL--RDSSFS----VQVPHALHTQDGVVTQKPGRGSLLWQDEPEH 95 Query: 137 ---RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 R+L F ++ I DAIE +G P D + NAV ++ Sbjct: 96 TSDRKLLAKEFTVRRM--QALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANAVPSMVIS 152 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 +FG +FQ + E + AA+ + Sbjct: 153 DLFGVPVE-RRAEFQDIAEAMMRVDQDAAATEA----------------------AGMRL 189 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 L +L+++ N L + DP L+ + G L+IA + Sbjct: 190 GGLLYQLVQERRANPGDDLISALI---------TTEDPDGVVDDMFLMNAAGTLLIAAHD 240 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 TT ++ + P+ ++++ L+ + E+LR+ Sbjct: 241 TTACMIGLGTALLLDSPDQLALLREDPSLV------------------GNAVEELLRYLT 282 Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 I G + D + G I KG V+ ++ + FD + +PE F R Sbjct: 283 IGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--------- 333 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR 484 + + F G C+G+ LAR+E+ + F L +R + V +L+ R Sbjct: 334 RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFR 384 >6M7X-A nrPDB Length = 484 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 92/409 (22%), Positives = 156/409 (38%), Gaps = 38/409 (9%) Query: 63 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 122 H+ + + Q G IF DLGG V + + V E L + R L ++ + Sbjct: 42 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHR 100 Query: 123 G---LLNSRYGRGWVDHR------RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYK 173 G + G W +R L+ N+ + F + + K ++ + Sbjct: 101 GHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKK--KVLQNAR 158 Query: 174 GR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAASA 224 G D + I + +NL +FGER + +F H +E +F V+L Sbjct: 159 GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM--- 215 Query: 225 SVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 F+ + W + +H F ++ + I+K PQ + + Sbjct: 216 --FMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAEL 270 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 343 + + S + + + EL +TT L + +A PN+Q +++E Sbjct: 271 LLNAE------LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 324 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403 + ++P A L E LR V L + S D V++ Y IP GT V Sbjct: 325 AASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVF 383 Query: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEH 452 LYS+ + + PE ++P+R+LD G + VPF G R CLG Sbjct: 384 LYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRR 431 >4ZGX-A nrPDB Length = 489 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 93/409 (22%), Positives = 158/409 (38%), Gaps = 38/409 (9%) Query: 63 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 122 H+ M + Q G IF +LGG V + + V E L + R L ++ + Sbjct: 42 HLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAYRQHR 100 Query: 123 G---LLNSRYGRGWVDHR------RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYK 173 G + G W +R L+ + + F + + K ++ + Sbjct: 101 GHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKK--KVLQNAR 158 Query: 174 GR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAASA 224 G D + I + +NL +FGER + +F H +E +F V+L Sbjct: 159 GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM--- 215 Query: 225 SVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 F+ + WI + +H F ++ + I+K PQH+ + Sbjct: 216 --FMPRSLSRWISPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAEL 270 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 343 + + + S E + + EL +TT L + +A P++Q +++E Sbjct: 271 LLKAE------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 324 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403 + ++P A L E LR V L + S D V++ Y IP GT V Sbjct: 325 AASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVF 383 Query: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEH 452 LYS+ + + PE ++P+R+LD G + VPF G R CLG Sbjct: 384 LYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRR 431 >4OQS-A nrPDB Length = 433 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 85/405 (20%), Positives = 145/405 (35%), Gaps = 88/405 (21%) Query: 89 LNGYDVVKECLVHQSEIFADRP--CLPLFMKMTKMGGLLNSRYGRGW---------VDHR 137 + + + ++ F++RP P+F + + GG + GW +R Sbjct: 50 VTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKA-PAPGWFINMDAPEHTRYR 106 Query: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197 R+ ++ F K E +I++ T+ DA+ G P D Q V ++ + G Sbjct: 107 RMLISQFTVRRI--KELEPRIVQITEDHLDAM-AKAGPPVDLVQAFALPVPSLVICELLG 163 Query: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257 +Y D F F E + AS ++ + ++ Sbjct: 164 --VSYADHAF------FQEQTTIMASVD---------------KTQDEVTTALGKLTRYI 200 Query: 258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTN 317 + L+ ++ K L + + + E L L++AG ETT N Sbjct: 201 AELVATKRLSPKDDLLGSLITD-------------TDLTDEELTNIALLLLVAGHETTAN 247 Query: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377 +L + +P + + + E+LR+ +IV L Sbjct: 248 MLGLGTFALLQHPEQIAAL-----------------------DSPDAVEELLRYLSIVHL 284 Query: 378 GIF-HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436 G A ED + G I KG TV L +V+ D K + +P++ +R Sbjct: 285 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDAR 336 Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHELV 478 F G CLG+ LAR+EM + FT L RF L P E + Sbjct: 337 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEI 381 >4OQR-A nrPDB Length = 457 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 84/405 (20%), Positives = 143/405 (35%), Gaps = 88/405 (21%) Query: 89 LNGYDVVKECLVHQSEIFADRP--CLPLFMKMTKMGGLLNSRYGRGW---------VDHR 137 + + + ++ F++RP P+F + + GG + GW +R Sbjct: 89 VTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKA-PAPGWFTNMDAPEHTRYR 145 Query: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197 R+ ++ F K E +I+ T+ DA+ G P D Q V ++ + G Sbjct: 146 RMLISQFTVRRI--KELEPRIVRITEDHLDAM-AKAGPPVDLVQAFALPVPSLVICELLG 202 Query: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257 +Y D F F E + S ++ + ++ Sbjct: 203 --VSYADHAF------FQEQTTIMVSVD---------------KTQDEVTTALGKLTRYI 239 Query: 258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTN 317 + L+ ++ K L + + + E L L++AG ETT N Sbjct: 240 AELVATKRLSPKDDLLGSLITD-------------TDLTDEELTNIALILLVAGHETTAN 286 Query: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377 +L + +P + + + E+LR+ +IV L Sbjct: 287 MLGLGTFALLQHPEQIANL-----------------------DSPDAVEELLRYLSIVHL 323 Query: 378 GIF-HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436 G A ED + G I KG TV L +V+ D K + +P++ +R Sbjct: 324 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDAR 375 Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHELV 478 F G CLG+ LAR+EM + FT L RF L P E + Sbjct: 376 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEI 420 >4GGV-A nrPDB Length = 418 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 77/425 (18%), Positives = 147/425 (34%), Gaps = 65/425 (15%) Query: 56 AASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLF 115 E P V+ Q ++++ + +LN +D L H + D P L Sbjct: 40 GQRPESPVVFDETQ-----GVWNVYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLE-- 92 Query: 116 MKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGR 175 G ++ +R+L +F E+++ + T+ DA++ Sbjct: 93 -------GDMSQMDPPRHRKYRQLVSRAFTPRLVAD--METRVADITRELLDAVDGK--- 140 Query: 176 PFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI 235 + I ++ +I+ E D + + + +++++ S FL + Sbjct: 141 ---PEIEIAADLAYPLPVIVIAELLGVPAGD-RDLFKKWADDIIEGFSGFSFLDTSGQ-- 194 Query: 236 GILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTF 295 + + D+++ + + + L H V A +D Sbjct: 195 ---GEQDVRDATERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVD---------GERL 242 Query: 296 SKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK 355 + ++ L++ G TTT L +L + P + +V+ + L+ G Sbjct: 243 TDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPG---------- 292 Query: 356 CKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWR 415 + E LR + + TS + V G IPK V+ L + + D + + Sbjct: 293 --------AIEEALRVLSP-SAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFT 343 Query: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH 475 DPEV+ P R + F G CLG LAR+E + AL RF + Sbjct: 344 DPEVYDPTRDPNP---------HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTD 394 Query: 476 ELVPD 480 P Sbjct: 395 PAKPP 399 >5L94-A nrPDB Length = 410 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 78/403 (19%), Positives = 141/403 (34%), Gaps = 65/403 (16%) Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 + YD VKE L ++ +DR + L+N + R L +F Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDP-PKHAEMRALVNKAFTP-- 105 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 K++E KI T +E + D + ++ + + I G + F+ Sbjct: 106 KAMKAWEPKIARITNELLQEVEHLE--DIDIVEHLSYPLPVMVIADILGVPIE-DQRQFK 162 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 ++ + A S + Q+ + + + R+IE+ Sbjct: 163 DWSDI------IVAGPSNNERETLEKLQ-------QEKMKANDELETYFYRIIEEKRTRP 209 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 + + A + + E ++ L+IAG ETTTN++ I + Sbjct: 210 GDDIISVLLQA---------KEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLME 260 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 ++++E +L+ + EVLR+ + V + ED Sbjct: 261 DKASFERLKREKELLPSG------------------IEEVLRYRSPVQ-ALHRIVKEDVT 301 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 + G + G V+ + S H D +Y+ DPEVF +R K + F G C Sbjct: 302 LAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNVHMAFGRGIHFC 352 Query: 449 LGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQP 491 LG LAR+E + L+ R+ P + L+P Sbjct: 353 LGAPLARIEAKIMLAELIDRY---------PQMDWSPSFELKP 386 >2Z36-A nrPDB Length = 413 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 80/403 (19%), Positives = 134/403 (33%), Gaps = 75/403 (18%) Query: 89 LNGYDVVKECLVHQSEIFADRPC--LPLFMK-------MTKMGGLLNSRYGRGWVDHRRL 139 ++G++ + L +D+ PLF + L+ G RR Sbjct: 51 VSGHEEARAVLAD-GRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRP 109 Query: 140 AVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGER 199 + F + +I + F D + RP D Q ++ V ++ + G Sbjct: 110 VIGEFTVKRLA--ALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVICELLG-- 165 Query: 200 FTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSR 259 Y D DF F + S + + R A + ++ Sbjct: 166 VPYTDHDF------FQSRTTMMVSRTSM----------------EDRRRAFAELRAYIDD 203 Query: 260 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVL 319 LI + L + + T L+ L+ AG ETT N++ Sbjct: 204 LITRKESEPGDDLFSRQI---------ARQRQEGTLDHAGLVSLAFLLLTAGHETTANMI 254 Query: 320 RWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGI 379 ++ + +P V+ T + E+LR+ I Sbjct: 255 SLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRYFTIADGVT 296 Query: 380 FHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALV 439 +ED + G SI G VI ++ S ++D ++DP V ER + Sbjct: 297 SRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER---------GARHHL 347 Query: 440 PFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELVP 479 F G CLG++LARME+ + F L +R L P E VP Sbjct: 348 AFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVP 390 >5OFQ-A nrPDB Length = 409 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 73/380 (19%), Positives = 137/380 (36%), Gaps = 62/380 (16%) Query: 89 LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFG 148 + Y+ VK L +F+ + + + +L R L +F Sbjct: 54 VFDYETVKYIL-KNPSLFSSKRAME-----ERQESILMMDP-PKHTKLRNLVNKAFTPRA 106 Query: 149 YGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 + E I E + D + + + FD + + I + G + F+ Sbjct: 107 I--QHLEGHIEEIADYLLDEVSSKE--KFDIVEDFAGPLPIIVIAELLGVPIQ-DRALFK 161 Query: 209 HMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNR 268 + +L + A AF + Q+ + + +I + N+ Sbjct: 162 KYSD------DLVSGAENNSDEAFAKMM-------QKRNEGVIFLQGYFKEIIAERQQNK 208 Query: 269 KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMAL 328 + L ++A +D ++E ++ L++AG ETTTN++ + +M Sbjct: 209 QEDLISLLLEAEID---------GEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTE 259 Query: 329 YPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV 388 ++Q +V+++I L+ ++ E LR+ + I +ED Sbjct: 260 DVDVQNEVRRDISLV------------------PNLVEETLRYYPPIQ-AIGRIAAEDVE 300 Query: 389 VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHC 448 + I +G VI+ S + D + P+ F R K V F G C Sbjct: 301 LGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR---------KTNPHVSFGFGIHFC 351 Query: 449 LGEHLARMEMFLFFTALLQR 468 LG LARME + FT LL++ Sbjct: 352 LGAPLARMEGKIAFTKLLEK 371 >3MZS-A nrPDB Length = 486 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 88/481 (18%), Positives = 174/481 (36%), Gaps = 36/481 (7%) Query: 30 LLKQRRPMG----FPPGPPGLPFIGNIYSLAASSELPHVYMR--KQSQVYGEIFSLDLGG 83 + + P PG G N+Y ++ R + Q YG I+ LG Sbjct: 1 MASTKTPRPYSEIPSPGDNGWL---NLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGN 57 Query: 84 ISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG----GLLNSRYGRGWVDHRR- 138 + +V + + V + + +R +P ++ + G+L + G W R Sbjct: 58 LESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSG-TWKKDRVV 115 Query: 139 -----LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPF-DFKQLITNAVSNITN 192 +A + + F + + G+ D K+ + + Sbjct: 116 LNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIK--QQGSGKFVGDIKEDLFHFAFESIT 173 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI-GILPFGKHQQLFRNAA 251 ++FGER + + F + V SV L N P + + + Sbjct: 174 NVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWD 233 Query: 252 VVYDFLSRLIEKASVN-RKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 310 +++ + E + R+ +++ + K E++ ++ E++ Sbjct: 234 TIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK------MLLEDVKANITEMLAG 287 Query: 311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 370 G TT+ L+W + MA N+Q +++E+ +P +A + E LR Sbjct: 288 GVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLR 347 Query: 371 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG 430 + + + D V++ Y IP T V +Y++ D ++ P+ F P R+L Sbjct: 348 LHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK 406 Query: 431 YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 + F G R C+G +A +EM LF +L+ F + H + D+ + L Sbjct: 407 DLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQH--IGDVDTIFNLILT 463 Query: 491 P 491 P Sbjct: 464 P 464 >4UBS-A nrPDB Length = 393 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 85/417 (20%), Positives = 145/417 (34%), Gaps = 77/417 (18%) Query: 83 GISTVVLNGYDVVKECLVHQSEIFADR------PCLPLFMKMTKMGGLLNSRYGRGWVDH 136 G S V+ G+ + L Q + +DR F + L Sbjct: 36 GRSVWVVTGHAAARALLSDQ-RLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQ 94 Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196 RR+ V SF + +I E DA+E +G P + + ++ + Sbjct: 95 RRMLVPSFTL--KRAAALRPRIQETVDGLLDAMEA-QGPPAELVSAFALPLPSMVICALL 151 Query: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256 G Y D DF S++ L + ++ A + D+ Sbjct: 152 G--VPYADHDFFE-----SQSRRLLRGPGI-----------------AEVQDARAQLDDY 187 Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316 L LI++ D LD++ Q + + + + L+ L+IAG ETT Sbjct: 188 LYALIDRKRKEPG--------DGLLDDLIQEQLNRGT-VDRAELVSLATLLLIAGHETTA 238 Query: 317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVP 376 N++ + +P +++ E L A + E+LRF +I Sbjct: 239 NMISLGTFTLLRHPEQLAELRAEPGL------------------MPAAVEELLRFLSIAD 280 Query: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436 G+ +ED V G +I V+ ++ D + +P+ R Sbjct: 281 -GLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR---------SAR 330 Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELVPDLKPRLGMTLQ 490 V F G CLG++LAR EM + L +R L P + +P + G T+Q Sbjct: 331 HHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIP---FKPGDTIQ 384 >2ZBZ-A nrPDB Length = 412 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 77/449 (17%), Positives = 138/449 (30%), Gaps = 76/449 (16%) Query: 53 YSLAASSELPHVY---MRKQSQVYGEIFSLDL-GGISTVVLNGYDVVKECL-------VH 101 + ++ P+ + G + + L G V+ ++ ++ L Sbjct: 14 PAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNR 73 Query: 102 QSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEE 161 + F P F + + RR+ ++ F K ++ E Sbjct: 74 TDDNFP--ATSPAFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRI--KGMRPEVEEV 129 Query: 162 TKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELA 221 F D + G D V ++ + G Y D +F + V+ Sbjct: 130 VHGFLDEMLAA-GPTADLVSQFALPVPSMVICRLLG--VPYADHEF--FQDASKRLVQST 184 Query: 222 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 281 Q + +L LI + L V L Sbjct: 185 --------------------DAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQL 224 Query: 282 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 341 + +E LI + L+IAG ETT ++ +++ + +P ++ + Sbjct: 225 ---------ANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRS 275 Query: 342 LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVI 401 L+ G + E+LR+ I + + D V G I G VI Sbjct: 276 LVPG------------------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVI 317 Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLF 461 + D + DP+ R + F G CLG++LAR+E+ + Sbjct: 318 VVNSIANRDGTVYEDPDALDIHR---------SARHHLAFGFGVHQCLGQNLARLELEVI 368 Query: 462 FTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 AL+ R V L R G T+Q Sbjct: 369 LNALMDRVPTLRLAVPVEQLVLRPGTTIQ 397 >4KPA-A nrPDB Length = 494 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 98/464 (21%), Positives = 181/464 (39%), Gaps = 35/464 (7%) Query: 45 GLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSE 104 LP + +++ P + K + GEIF + G T L+ ++KE +S Sbjct: 40 NLPLL--------NTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA-CDESR 90 Query: 105 IFADRPCLPLFMKMTKMGGLLNS-RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETK 163 + F++ GL S + + W + + SF K + + +++ Sbjct: 91 FDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFS--QQAMKGYHAMMVDIAV 148 Query: 164 FFNDAIETYKGRP-FDFKQLITNAVSNITNLIIFGERFT--YEDTDFQHMIELFSENVEL 220 E + + +T + L F RF Y D + + E Sbjct: 149 QLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEA 208 Query: 221 AASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAY 280 + +Q + V+ D + ++I + + D Sbjct: 209 MNKLQRANPD-----DPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQS------DDL 257 Query: 281 LDEMDQGKN-DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKE 339 L M GK+ + EN+ + + +IAG ETT+ +L +A+ F+ P++ + +E Sbjct: 258 LTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEE 317 Query: 340 IDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRG-YSIPKGT 398 ++ + PS+ ++ Y VL+E LR P ED V+ G Y + KG Sbjct: 318 AARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL-YAKEDTVLGGEYPLEKGD 375 Query: 399 TVITNLYSVHFDEKYW-RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 ++ + +H D+ W D E F PERF + S + A PF G+R C+G+ A E Sbjct: 376 ELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHE 433 Query: 458 MFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 L +L+ F D+K +TL+P+ +++ A+ + Sbjct: 434 ATLVLGMMLKHFDFEDHTNYELDIKET--LTLKPEGFVVKAKSK 475 >3N9Z-A nrPDB Length = 487 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 87/472 (18%), Positives = 166/472 (35%), Gaps = 23/472 (4%) Query: 35 RPMGFPPGPPGLPFIGNIYSLAASSELPHVYMR--KQSQVYGEIFSLDLGGISTVVLNGY 92 RP P P ++ N+Y + V++ + Q YG I+ LG + +V + Sbjct: 6 RPFNEIPSPGDNGWL-NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDP 64 Query: 93 DVVKECLVHQSEIFADR---PCLPLFMKMTKMGGLLNSRYGRGWVDHRR------LAVNS 143 + V + +R P + + + + + W R +A + Sbjct: 65 EDVALLFKSEGPN-PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEA 123 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 + F + + D + +IFGER Sbjct: 124 TKNFLPLLDAVSRDFVSVLHRRIKK-AGSGNYSGDISDDLFRFAFESITNVIFGERQGML 182 Query: 204 DTDFQHMIELFSENVELAASASVFLYNAFPWI-GILPFGKHQQLFRNAAVVYDFLSRLIE 262 + + F + + SV + N P + + + V++ + Sbjct: 183 EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQ 242 Query: 263 KASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWA 322 + + H Y + + D S S E++ +V E++ G +TT+ L+W Sbjct: 243 NFYWELRQKGSVHH--DYRGILYRLLGD--SKMSFEDIKANVTEMLAGGVDTTSMTLQWH 298 Query: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382 + MA +Q ++ E+ +P +A + E LR + + + Sbjct: 299 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRY 357 Query: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS 442 D V+R Y IP T V +Y++ + ++ DPE F P R+L + F Sbjct: 358 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY-FRNLGFG 416 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPY 494 G R CLG +A +EM +F +L+ F + H + D+ + L P+ Sbjct: 417 WGVRQCLGRRIAELEMTIFLINMLENFRVEIQH--LSDVGTTFNLILMPEKP 466 >3EJB-B nrPDB Length = 404 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 72/439 (16%), Positives = 137/439 (31%), Gaps = 70/439 (15%) Query: 54 SLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP 113 + + +R +Y F G + GY+ L + F R LP Sbjct: 10 EFLKNPYSFYDTLRAVHPIYKGSFLKYPGW----YVTGYEETAAIL--KDARFKVRTPLP 63 Query: 114 LFMKMTKMGGLLNSRY-----GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDA 168 + + ++ R LA +F +S++ I+E D Sbjct: 64 ESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTT--ESYQPYIIETVHHLLDQ 121 Query: 169 IETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL 228 ++ + + +++ I G + + + ++ S Sbjct: 122 VQGK--KKMEVISDFAFPLASFVIANIIGVP-EEDREQLKEWAASLIQTIDFTRSRKALT 178 Query: 229 YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288 A + LI+K + + + + K Sbjct: 179 EGNIM----------------AVQAMAYFKELIQKRKRHPQQDMISMLL----------K 212 Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 ++E + L IAG ETT N++ ++L + +P ++++ DLI Sbjct: 213 GREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI----- 267 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 + E LR+ + + SED + G +I +G V L + + Sbjct: 268 -------------GTAVEECLRYESPTQMTA-RVASEDIDICGVTIRQGEQVYLLLGAAN 313 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 D + +P+VF R + + F G CLG LAR+E + LLQR Sbjct: 314 RDPSIFTNPDVFDITRSPNP---------HLSFGHGHHVCLGSSLARLEAQIAINTLLQR 364 Query: 469 FHLHFPHELVPDLKPRLGM 487 + +P G Sbjct: 365 MPSLNLADFEWRYRPLFGF 383 >4RM4-A nrPDB Length = 396 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 62/359 (17%), Positives = 117/359 (32%), Gaps = 56/359 (15%) Query: 121 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180 ++N R + +F Q +E +I E T + FD Sbjct: 78 GNSIINMDP-PKHTKIRSVVNKAFTPRVMKQ--WEPRIQEITDELIQKFQGR--SEFDLV 132 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 + + I + G + + A + + + Sbjct: 133 HDFSYPLPVIVISELLGVP--------------SAHMEQFKAWSDLLVSTPKDKSEEAEK 178 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 ++ + + F + +IE+ + + V+A + S E L Sbjct: 179 AFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEA---------EETGEKLSGEEL 229 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 I L++AG ETTTN++ A+ + P + +++ +L Sbjct: 230 IPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPEL------------------ 271 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 + E LRF P+ + D + G+ I +G V+ + S + DE + P +F Sbjct: 272 MPQAVEEALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMF 330 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP 479 R + + F G CLG LAR+E + T+L+ F + P Sbjct: 331 DIRRHPNP---------HIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITP 380 >5VWS-A nrPDB Length = 393 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 73/395 (18%), Positives = 131/395 (33%), Gaps = 62/395 (15%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWV 134 ++ G + YD V++ L +DR L + GG+ Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDP-PEHR 87 Query: 135 DHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLI 194 RRL ++F + E +I + D + G FD + + I Sbjct: 88 HQRRLITHAFTPQSI--SAMEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAE 142 Query: 195 IFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVY 254 + G + F+ + +++ A L + + + Sbjct: 143 LLGVP-PGDRHLFRTWSDRLMS-LQVENYADPEL--------------ARTVAAAMTEMN 186 Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314 D+L + + L V A ++ E ++ + L++AG T Sbjct: 187 DYLREHCRSRRTHPRDDLLTRLVQAEVE---------GKRLDLEEVVNTASLLLLAGHLT 237 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 TT ++ +L + +P + V+ + LI A L E LR + Sbjct: 238 TTVLIGNTMLCLWDHPEAEKAVRADPSLI------------------PAALEESLRLRSP 279 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 L T+ D + G +IP V+ + S + D++ + DPE F R + Sbjct: 280 F-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR---------Q 329 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + F G CLG L R+E + LL RF Sbjct: 330 TTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >2VZM-A nrPDB Length = 436 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 106/339 (31%), Gaps = 61/339 (17%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R+L F + ++ E DA+ D + + + Sbjct: 117 PPRHTRLRKLVAREFTM--RRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPI 174 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + G + F+ + F + Q Sbjct: 175 TVISELLGVP-EPDRAAFRVWTDAF-----------------------VFPDDPAQAQTA 210 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 A + +LSRLI+ L + + ++ S + E L+ L++ Sbjct: 211 MAEMSGYLSRLIDSKRGQDGED--------LLSALVRTSDEDGSRLTSEELLGMAHILLV 262 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG ETT N++ + + +P+ ++ + M + + E+L Sbjct: 263 AGHETTVNLIANGMYALLSHPDQLAALRAD------------------MTLLDGAVEEML 304 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R+ V + E + G IP G TV+ L H + + DP F R Sbjct: 305 RYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR----- 359 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 + F G C+G LAR+E + ALL+R Sbjct: 360 ----DTAGHLAFGHGIHFCIGAPLARLEARIAVRALLER 394 >4YZR-A nrPDB Length = 405 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 66/364 (18%), Positives = 129/364 (35%), Gaps = 62/364 (17%) Query: 127 SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNA 186 ++ R L +F ++ I + + D +E D + + Sbjct: 93 AKDTPDHTRLRSLVHQAFTPRTI--ENLRGSIEQIAEQLLDEMEKENKA--DIMKSFASP 148 Query: 187 VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL 246 + I + G + + FQ + E G + Sbjct: 149 LPFIVISELMGIP-KEDRSQFQIWTNAMVDTSE---------------------GNRELT 186 Query: 247 FRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGE 306 + D++++LI + K L V A + S S++ L + Sbjct: 187 NQALREFKDYIAKLIHDRRIKPKDDLISKLVHA---------EENGSKLSEKELYSMLFL 237 Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L++AG ETT N+L L + + +++++ ++I + Sbjct: 238 LVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------------TAVE 279 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E+LR+ + V + ED +G+SI +G + + S + D ++ +PE+ + R Sbjct: 280 ELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSP 339 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLG 486 + + F G CLG LAR+E + F ALL+RF D++ R Sbjct: 340 NR---------HISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKN 390 Query: 487 MTLQ 490 + L+ Sbjct: 391 VFLR 394 >1Z8P-A nrPDB Length = 404 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 64/428 (14%), Positives = 129/428 (30%), Gaps = 74/428 (17%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMT--------KMGGLLN 126 + + G ++ GYD K L + P + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 127 SRYG----RGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQL 182 + G R+L F ++ ++ + T D + D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFTV--RRVEAMRPRVEQITAELLDEVGDS--GVVDIVDR 143 Query: 183 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 242 + + + G Y I ++ + Sbjct: 144 FAHPLPIKVICELLGVDEKYR----------------------GEFGRWSSEILVMDPER 181 Query: 243 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIF 302 +Q + A V +F+ L+E+ D L + + ++D S + L Sbjct: 182 AEQRGQAAREVVNFILDLVERRRTEPG--------DDLLSALIRVQDDDDGRLSADELTS 233 Query: 303 SVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTE 362 L++AG E++ +++ + +P+ V+++ Sbjct: 234 IALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPS------------------ALP 275 Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 + E+LR+ P +E+ + G +IP+ +TV+ + + D K + DP F Sbjct: 276 NAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDV 334 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLK 482 R + F G C+G LA++E + AL RF D+ Sbjct: 335 TR---------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVV 385 Query: 483 PRLGMTLQ 490 R + L+ Sbjct: 386 WRRSLLLR 393 >5CJE-A nrPDB Length = 393 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 81/460 (17%), Positives = 144/460 (31%), Gaps = 79/460 (17%) Query: 49 IGNIYSLAASS----ELPHVYMRKQSQVYGEIFSLDLGGISTV---VLNGYDVVKECLVH 101 +GN+ L E P+ + + G + + ++ G++ + L Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 102 QSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEE 161 + + MG L R L +F ++ +I E Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTM--RRVEALRPRIQEI 117 Query: 162 TKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELA 221 T D + +GR D + + G + F+ + Sbjct: 118 TDGLLDEM-LPRGRA-DLVDSFAYPLPITVICELLGVP-DIDRVTFRALSNEI------- 167 Query: 222 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 281 + P G +L + +L LI+ D L Sbjct: 168 ---------------VAPTGGDAELA-AYERLAAYLDELIDDKRST-------APADDLL 204 Query: 282 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 341 ++ + + + S E L L++AG ETT N++ + + +P+ ++ + Sbjct: 205 GDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD-- 262 Query: 342 LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVI 401 M + + EVLRF V + +E + G +I +G V+ Sbjct: 263 ----------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVM 306 Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLF 461 L + D DP VF R + + F G +CLG LAR+E + Sbjct: 307 IGLDAAGRDPARHPDPHVFDIHR---------APQGHLAFGHGIHYCLGAPLARLEARVA 357 Query: 462 FTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 +LL+R PDL +P LI RR Sbjct: 358 LRSLLERC---------PDLALDGPPGARPPGMLIRGVRR 388 >1ODO-A nrPDB Length = 408 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 87/459 (18%), Positives = 148/459 (32%), Gaps = 72/459 (15%) Query: 53 YSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCL 112 L + H R + G +D+ G+ ++ ++K+ L R Sbjct: 8 LVLDPTGADHHTEHRTLREG-GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHW 66 Query: 113 PLFMKMTKMGGLL--------NSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKF 164 P F ++ L + YG RRL +F + + Sbjct: 67 PAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLVAPAFS--ARRVDAMRPAVEAMVTG 124 Query: 165 FNDAIETY-KGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAAS 223 D + G P D +Q + + + G D F+ +++ + Sbjct: 125 LVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVPQDRRDG-FRALVDGVFDTT----- 178 Query: 224 ASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 + N A +Y+ L +LI + + A DE Sbjct: 179 -----------------LDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDE 221 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 343 S E L ++ +I AG ETT NV+ A+ + P+ V+K Sbjct: 222 ------GDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK----- 270 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV-RGYSIPKGTTVIT 402 G+ +W D V+ E LR V D + G +I +G ++ Sbjct: 271 ----GEVTWAD---------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILA 317 Query: 403 NLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFF 462 + + + + D + F R + + F G CLG LARME+ L Sbjct: 318 SYAAANRHPDWHEDADTFDATRTVKE---------HLAFGHGVHFCLGAPLARMEVTLAL 368 Query: 463 TALLQRF---HLHFPHELVPDLKPRLGMTLQPQPYLICA 498 +L RF L P E +P + + Q P L+ A Sbjct: 369 ESLFGRFPDLRLADPAEELPPVPSLISNGHQRLPVLLHA 407 >4Z5P-A nrPDB Length = 400 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 67/391 (17%), Positives = 131/391 (33%), Gaps = 63/391 (16%) Query: 110 PCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI 169 P + + + S RRL +F G + +S + E D + Sbjct: 71 EDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMG--AMQSWLEELFAGLLDGV 128 Query: 170 ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLY 229 E G P D + + + + G + + FQH E+ Sbjct: 129 ERT-GHPADIVRDLAQPFTIAVICRLLGVPYE-DRGRFQHWSEVIMSTTAY--------- 177 Query: 230 NAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 289 ++ A + +L+ L+ D L + ++ Sbjct: 178 ------------SKEEAVSADASIRAYLADLVSARRAAPH--------DDLLGVLVSARD 217 Query: 290 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 349 D +++ LI L++AG ET+ + L + + + + ++++ +L+ Sbjct: 218 DD-DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELL------ 270 Query: 350 PSWDDKCKMPYTEAVLHEVLRFCNIVP-LGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 + E+LRF + +G ED + G ++ G V+ + + Sbjct: 271 ------------PRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNAN 318 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 D + + DP+ R +K + F G +CLG LARME+ + LL+R Sbjct: 319 RDPRAFDDPDRLDITR---------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLER 369 Query: 469 FHLHFPHELVPDLKPRLGMTLQ-PQPYLICA 498 F ++ + G + PQ I Sbjct: 370 FPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 400 >3A50-A nrPDB Length = 411 Score = 204 bits (518), Expect = 9e-53, Method: Composition-based stats. Identities = 76/395 (19%), Positives = 128/395 (32%), Gaps = 66/395 (16%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLV--HQSEIFADR-PCLPLFMKMTKMGGLLNSRYGR 131 + L L +L Y V+E V S+ + R P ++ Sbjct: 34 PVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPP 93 Query: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191 R+L SF E +I E + T P D + + Sbjct: 94 DHTRLRKLVGRSFTVRRM--NELEPRITEIADGLLAGLPTD--GPVDLMREYAFQIPVQV 149 Query: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251 + G L +E+ + ++ S L + P Sbjct: 150 ICELLG---------------LPAEDRDDFSAWSSVLVDDSP---------ADDKNAAMG 185 Query: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311 ++ +LS L+E+ DA L + + S+E L+ L+IAG Sbjct: 186 KLHGYLSDLLERKRTEPD--------DALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAG 237 Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371 ETT N++ +L + +P+ + + ++ LI + + E LRF Sbjct: 238 HETTVNLIGNGVLALLTHPDQRKLLAEDPSLI------------------SSAVEEFLRF 279 Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431 + V T+ED G +IP G V+ L + + D + +P+ R Sbjct: 280 DSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR------- 332 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 V F G CLG LAR+E + L Sbjct: 333 --DASGGVFFGHGIHFCLGAQLARLEGRVAIGRLF 365 >5NWS-A nrPDB Length = 435 Score = 204 bits (518), Expect = 9e-53, Method: Composition-based stats. Identities = 75/432 (17%), Positives = 142/432 (32%), Gaps = 85/432 (19%) Query: 74 GEIFSLDLG-GISTVVLNGYDVVKECLVHQSEIFADRPC-------------------LP 113 G + G + YD V+ L + F + P +P Sbjct: 47 GPVVRGRFVDGTPVWFVTRYDDVRAVL--RDPRFVNTPSPVPGEGGADPREGMMDLLNVP 104 Query: 114 LFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI--ET 171 +++ +G +L+S RRL +F I + Sbjct: 105 EPLRVYLLGSILDSDP-PDHPRLRRLVTRAFAARRIL--GLRPGIERIADRLLAELPRRE 161 Query: 172 YKGRPFDFKQLITNA-VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 230 + D + + EL + L Sbjct: 162 EEDGTVDLLEHFAYPLSITVIC--------------------------ELVGIPATDLER 195 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 W G L + ++L + V+ D+ RLIE+ D L E+ + ++D Sbjct: 196 WREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQRRA--------ALTDDLLSELIRAQDD 247 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 S + + L++AG ET+ +++ + +P ++K+ L+ Sbjct: 248 DGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPALL------- 300 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 +HE++R+C V + +ED + G + +G V L S +FD Sbjct: 301 -----------PRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFD 349 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 +++ DP+ R + + E V F G +CLG LAR E + LL+ + Sbjct: 350 PRHYSDPDRLDITRHQE-----GQAENHVGFGHGIHYCLGATLARQEGEVALARLLETYP 404 Query: 471 LHFPHELVPDLK 482 + P+++ Sbjct: 405 DLALADGDPEVR 416 >6GMF-A nrPDB Length = 397 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 75/394 (19%), Positives = 132/394 (33%), Gaps = 64/394 (16%) Query: 80 DLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPL----FMKMTKMGGLLNSRYGRGWVD 135 L + + Y V L ++ F++R T M + Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195 R L +F Q E +I + D + F+ +T + I + Sbjct: 90 LRTLVTKAFTPRTVAQ--LEPRIRDIAHELVDGLRGK--STFEATVEVTVPMPMIVIAEM 145 Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255 G DF+ + + + ++ G QL R+ Y Sbjct: 146 LGV-APERRADFKRWSD-----------------DMVGSLALVRVGNAAQLERSTQEFYA 187 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + S ++E+ + L + A +D + ++ L+IAG ETT Sbjct: 188 YFSEVLEERRREPREDLISQLLAAEVD---------GEKLTAGEVLSFANTLLIAGNETT 238 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T+++ A++ + +P Q ++ L+ AV+ EVLR+ + Sbjct: 239 TSLIGNALVALTDHPEQLAAAQADLSLV------------------PAVVEEVLRYESPA 280 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 IF T D + IP + V+ L S + DE + DP+ F R Sbjct: 281 QC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR---------DT 330 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 + + F L C+G LAR+E + LL R Sbjct: 331 KGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >3ABB-A nrPDB Length = 408 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 79/438 (18%), Positives = 145/438 (33%), Gaps = 75/438 (17%) Query: 53 YSLAASSELPHVYMRKQSQVYG--EIFSLDLG-GISTVVLNGYDVVKECLVH-QSEIFAD 108 S P+ + + G + + L G ++ G+ + LV + Sbjct: 14 PSFPQDRTCPYQPPKAYEERRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWG 73 Query: 109 RPCLPLFMKMTKMGGLLN----SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKF 164 P P+ ++ T+ G L RR+ + SF + ++ Sbjct: 74 HPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQRRMLIPSF--GVKRMNAIRPRLQSLVDR 131 Query: 165 FNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASA 224 D + KG D V ++ + G + D F+ F A + Sbjct: 132 LLDDMLA-KGPGADLVSAFALPVPSVAICELLGVPYGDHDF-FEECSRNFVGAATSAEAD 189 Query: 225 SVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEM 284 + F +Y +L L+ + + D LDE+ Sbjct: 190 AAF-----------------------GELYTYLHGLVGRKQAEPE--------DGLLDEL 218 Query: 285 DQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIM 344 + + + ++ L++AG ETT N + L + +P + ++ + Sbjct: 219 IARQLEEGD-LDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVS 277 Query: 345 GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNL 404 G V+ E+LRF ++ I ED V G +I G V+ ++ Sbjct: 278 G------------------VVEELLRFTSVSDH-IVRMAKEDIEVGGATIKAGDAVLVSI 318 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464 ++ D K + +P++F R V F G CLG++LAR E+ + Sbjct: 319 TLMNRDAKAYENPDIFDARR---------NARHHVGFGHGIHQCLGQNLARAELEIALGG 369 Query: 465 LLQR---FHLHFPHELVP 479 L R L P + VP Sbjct: 370 LFARIPGLRLAVPLDEVP 387 >3TYW-A nrPDB Length = 417 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 81/439 (18%), Positives = 142/439 (32%), Gaps = 77/439 (17%) Query: 36 PMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTV-VLNGYDV 94 P PP P Y ++ + + L V+ YD Sbjct: 13 PGATPPRDFP-------IQRGCPFAAPAEYAALRTDD--PVARVTLPTRREAWVVTRYDD 63 Query: 95 VKECLVH-QSEIFADRPCLPLFMKMTKMGGLLNSRY----GRGWVDHRRLAVNSFRYFGY 149 V+E L + RP P + + G + +RR+ + +F Sbjct: 64 VRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLPAFTV--R 121 Query: 150 GQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQH 209 ++ + D + G P D NAVS + G D +F Sbjct: 122 RVRAMRPAVQARVDEILDGMLAA-GGPVDLVSAYANAVSTSVICELLG--IPRHDLEF-- 176 Query: 210 MIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRK 269 + I +Q+ ++ L L+ + + Sbjct: 177 -------------------FRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPR 217 Query: 270 PQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALY 329 L V +L + E L+ ++G I AG ETTT+++ + L + Sbjct: 218 DDLISKLVTDHLVP---------GNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDR 268 Query: 330 PNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV 389 P + +++K+ DL A + E+LR ++ +ED + Sbjct: 269 PELPAELRKDPDL------------------MPAAVDELLRVLSVADSIPLRVAAEDIEL 310 Query: 390 RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCL 449 G ++P VI L + D + + DPE R + V F G C+ Sbjct: 311 SGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN---------HHVAFGYGVHQCV 361 Query: 450 GEHLARMEMFLFFTALLQR 468 G+HLAR+E+ + LL+R Sbjct: 362 GQHLARLELEVALETLLRR 380 >5XNT-A nrPDB Length = 411 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 59/388 (15%), Positives = 131/388 (33%), Gaps = 69/388 (17%) Query: 118 MTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPF 177 + + + R L +F +++E +I E + ++ Sbjct: 82 VPDKIKITEADPPEHRKR-RSLLAAAFTPRSL--QNWEPRIQEIADELIEEMDEET--EI 136 Query: 178 DFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI 237 D Q + + + I + G + + F+ +++ P+ Sbjct: 137 DIVQSLASPLPIIVMSDLMGVP-SKDRLLFKKWVDIL----------------FLPFDKE 179 Query: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSK 297 ++ A Y +L ++ + +N + + A +D F+ Sbjct: 180 KQEEVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVD---------GEMFTD 230 Query: 298 ENLIFSVGELIIAGTETTTNVLRWAILFMA-LYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356 + ++ + ++ AG ETT+++L + + + ++ + +DL+ Sbjct: 231 DEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------- 277 Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416 + E+LR+ + + ED + G + +G V+ + + + DE+ + D Sbjct: 278 -----PQAVEEMLRYR-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFED 331 Query: 417 PEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476 + R + + F G CLG LAR+E + T L++F E Sbjct: 332 AFTLNIHR--------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK---HIE 380 Query: 477 LVPDLKPR-------LGMTLQPQPYLIC 497 VP + G TL P C Sbjct: 381 AVPSFQLEDNLTDSATGQTLTSLPLKAC 408 >2Y5N-A nrPDB Length = 417 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 75/394 (19%), Positives = 130/394 (32%), Gaps = 76/394 (19%) Query: 113 PLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172 P GGLL+ RRL V +F +S + E D + Sbjct: 92 PRTRPEMVKGGLLSMDP-PEHSRLRRLVVKAFT--ARRAESLRPRAREIAHELVDQMAAT 148 Query: 173 KGRPFDFKQLITNAVSNITNLIIFG------ERFTYEDTDFQHMIELFSENVELAASASV 226 G+P D + + + G +RFT F E+ +E ++ Sbjct: 149 -GQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQ------- 200 Query: 227 FLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQ 286 A Y ++ LI++ L V A Sbjct: 201 ---------------------EAAEQAYAYMGDLIDRRRKEPTDDLVSALVQA------- 232 Query: 287 GKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGP 346 D + S++ L+ L++AG E+TT + + + P ++ Q+ +LI Sbjct: 233 --RDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELI--- 287 Query: 347 NGKPSWDDKCKMPYTEAVLHEVLRFCNI-VPLGIFHATSEDAVVRGYSIPKGTTVITNLY 405 + + E+ R+ + V ED +RG +I G V+ + Sbjct: 288 ---------------PSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTG 332 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465 + + D+ + D + +R + + F G HCLG LAR+E+ + L Sbjct: 333 AANRDQAQFPDADRIDVDRTPN---------QHLGFGHGVHHCLGAPLARVELQVALEVL 383 Query: 466 LQRFHLHFPHELVPDLKPRLGMTLQ-PQPYLICA 498 LQR L+ GM L+ P + Sbjct: 384 LQRLPGIRLGIPETQLRWSEGMLLRGPLELPVVW 417 >5YSW-A nrPDB Length = 441 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 79/422 (18%), Positives = 138/422 (32%), Gaps = 80/422 (18%) Query: 74 GEIFSLDLG-GISTVVLNGYDVVKECLVHQSEIFADRPCL--------PLFMKMTKMGGL 124 G + L G +++GY+ + L +DR P F + + Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDP-RFSSDRFQYHPWFKELSPEFRERLRDDKA 122 Query: 125 LNSRY----GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180 + +R+L F + ++I E DA+ G D Sbjct: 123 RAGSFINMDPPEHTRYRKLLTGQFTVRRI--RELGARIDEIVAGRVDAMLAG-GTTADLM 179 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 ++ + G R+ + +FQ + Sbjct: 180 TEFAFPAPSLMICELLGVRYE-DRAEFQQRASALLQM----------------------N 216 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 + +NA + F+ L+ N + + + + L Sbjct: 217 APVAEAVKNADALRAFMQALVTDKRANPAGDIISGLI---------HHAGADPALTDDEL 267 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 I L+IAG +TT ++L I + P ++ + I Sbjct: 268 INIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD--------------- 312 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 + E+LR+ ++V GIF ED G IP G+TV+ ++ + + D ++W DP+ Sbjct: 313 ---AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD-L 368 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHEL 477 R + + F G CLG+ LARMEM + LL+R L P E Sbjct: 369 DLTR---------PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEE 419 Query: 478 VP 479 VP Sbjct: 420 VP 421 >5EX6-C nrPDB Length = 434 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 74/437 (16%), Positives = 136/437 (31%), Gaps = 83/437 (18%) Query: 74 GEIFSLDLGG----ISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 129 GE+ + LG T + G+DVV++ L + F+ R ++ G+ R Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTR-FSTRRRFDRNDEI-GGKGVFRPRE 119 Query: 130 ---------GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180 RRL F + + I + D +E +G P D Sbjct: 120 LVGNLMDYDPPEHTRLRRLLAPGFTHRKIRR--MAPYIEQIVTERLDEMER-EGSPADLI 176 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 +L + V + G D + + Sbjct: 177 ELFADEVPGPVLCELLGVP---RDDRAMFLQLCHRHLDASLS------------------ 215 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 ++ +L ++ + + L V + T + E L Sbjct: 216 --GRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVA-----------EHGDTVTDEEL 262 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 ++++AG + + ++ +L + P ++ ++ P Sbjct: 263 RGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV------------------PA 304 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 E + E++R+ + ED+ V I G TV+ +L + + D D + Sbjct: 305 AERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRL 364 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD 480 R + V F G HCLG LAR+E+ + +TAL +RF P + D Sbjct: 365 DVTR---------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRF----PDLRLAD 411 Query: 481 LKPRLGMTLQPQPYLIC 497 L Y I Sbjct: 412 PDGATEFRLSTPAYGIS 428 >4YT3-A nrPDB Length = 410 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 57/360 (15%), Positives = 125/360 (34%), Gaps = 61/360 (16%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R L +F +++E +I E ++ G D + + + Sbjct: 93 PPDHRKRRSLLAAAFTPRSL--QNWEPRIQEIADELIGQMDG--GTEIDIVASLASPLPI 148 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 I + G + + F+ ++ P+ + Sbjct: 149 IVMADLMGVP-SKDRLLFKKWVDTL----------------FLPFDREKQEEVDKLKQVA 191 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 A Y +L ++ + +N + + + +D F+ + ++ + ++ Sbjct: 192 AKEYYQYLYPIVVQKRLNPADDIISDLLKSEVD---------GEMFTDDEVVRTTMLILG 242 Query: 310 AGTETTTNVLRWAILFMA-LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368 AG ETT+++L + + + ++ + +DL+ + E+ Sbjct: 243 AGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------PQAVEEM 284 Query: 369 LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428 LRF + + ED + G + +G +V+ + + + DE+ + DP + R Sbjct: 285 LRFR-FNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR---- 339 Query: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT 488 + + F G CLG LAR+E + TA L++F E VP + +T Sbjct: 340 ----PNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK---HIEAVPSFQLEENLT 392 >1UED-A nrPDB Length = 406 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 76/427 (17%), Positives = 135/427 (31%), Gaps = 73/427 (17%) Query: 78 SLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLF----MKMTKMGGLLNSRYGRGW 133 S LG +GY+VV+ L E F RP + G +++ Sbjct: 47 STQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEH 105 Query: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 R++ F + E I D +E +G D + L + V Sbjct: 106 TRLRKMLTPEFTVRRIRR--MEPAIQSLIDDRLDLLEA-EGPSADLQGLFADPVGAHALC 162 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 + G + +F +++ RNA + Sbjct: 163 ELLGIPRD-DQREF-----------------------------------VRRIRRNADLS 186 Query: 254 YDFLSRLIEKASVNR--KPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311 +R + A+ NR L + D + D + E L LI+ G Sbjct: 187 RGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDNVTDEELKGLCTALILGG 246 Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371 ET ++ + +L + P + + + E V++E++R+ Sbjct: 247 VETVAGMIGFGVLALLDNPGQIELLFESPE------------------KAERVVNELVRY 288 Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431 + V +D V+ G I G V+ ++ + DE DP+V R S Sbjct: 289 LSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVSD-- 346 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQP 491 V F G +C+G LAR + + + L +RF + ++K R P Sbjct: 347 -------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVDCP 399 Query: 492 QPYLICA 498 + Sbjct: 400 DQVPVTW 406 >4XE3-A nrPDB Length = 407 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 60/382 (15%), Positives = 121/382 (31%), Gaps = 62/382 (16%) Query: 110 PCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI 169 P P + ++ RRL +F + ++ D + Sbjct: 78 PATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT--ARRVEEMRPRVRSLVDSLLDDM 135 Query: 170 ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLY 229 + G P D + + + G D F+ + + L A+ Sbjct: 136 VAH-GSPADLVEFLAVPFPVAVICELLGVPLEDRDL-FRTFSDAMLSSTRLTAA------ 187 Query: 230 NAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 289 ++ R ++ L+ + + L + Sbjct: 188 ---------------EIQRVQQDFMVYMDGLVAQRRDAP--------TEDLLGALALA-T 223 Query: 290 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 349 D +K ++ L+IAG ET+ N + + + + + L+ Sbjct: 224 DNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPALV------ 277 Query: 350 PSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF-HATSEDAVVRGYSIPKGTTVITNLYSVH 408 A + E+LR+ +V G F +ED + ++ G + + S + Sbjct: 278 ------------PAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASAN 325 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 DE+ + + R ++ + F G HC+G L R+E+ +AL++R Sbjct: 326 RDEEVFDHADELDFHR---------ERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRR 376 Query: 469 FHLHFPHELVPDLKPRLGMTLQ 490 F E V LK + GM ++ Sbjct: 377 FPTLDLAEPVAGLKWKQGMLIR 398 >5LIE-A nrPDB Length = 414 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 67/361 (18%), Positives = 115/361 (31%), Gaps = 55/361 (15%) Query: 109 RPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDA 168 R + + G +LN RRL + + E + + D Sbjct: 79 RFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRR--VEDDLRRRARGLLDG 136 Query: 169 IETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL 228 +E G PFDF I + I+ G +TD + E + S + Sbjct: 137 VE--PGAPFDFVVEIAAELPMQMICILLGV----PETDRHWLFEAVEPGFDFRGSRRATM 190 Query: 229 YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 288 + + +Y + LI + +A +D Sbjct: 191 PRL-------------NVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATID------ 231 Query: 289 NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 348 + + S L L AG ETT N + +L +A P+ ++ + +L+ Sbjct: 232 DPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELL----- 286 Query: 349 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 408 + E++R+ + P S + G I G V+ S + Sbjct: 287 -------------PTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSAN 332 Query: 409 FDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 D + + F R K + F G +CLG +LAR+E+ + F LL R Sbjct: 333 RDPSVFDRADEFDITR---------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSR 383 Query: 469 F 469 F Sbjct: 384 F 384 >4JBT-A nrPDB Length = 410 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 135/425 (31%), Gaps = 78/425 (18%) Query: 74 GEIFSLDLGGISTVVLNGYDVVKECLVHQ-----------SEIFADRPCLPLFMKMTKMG 122 G + +DL G+ + + G+ + ++ L + PL + Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPFDFK 180 + G R + + + I D +E G D K Sbjct: 90 SMFTVD-GPEHRRLRIKTTQALTRRRL--DALKPTIERYVAELLDDLERAGADGAVVDLK 146 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 + + + G ED + +L F P Sbjct: 147 SVFAYPLPMRVISALMG--VPSEDQE------------QLLTWYKAFFSILTP------- 185 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 + R ++ + + ++ + + L + A D + ++E + Sbjct: 186 --QDERLRVIDEMHGYFTEMVRRKTAEPGDDLTSALIYA---------TDGETPLTEEEV 234 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 I ++ L+ AG ETT +++ A+ + +P V+ +G+ W Sbjct: 235 IGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---------DGEIGW-------- 277 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-RDPEV 419 E + E LR+ V + +ED + IP+G V+ + ++ D D + Sbjct: 278 -ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADD 336 Query: 420 FHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHE 476 F R A + F G C G LAR+E + AL RF H P + Sbjct: 337 FDITR--------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLD 388 Query: 477 LVPDL 481 +P+L Sbjct: 389 QIPNL 393 >1EHE-A nrPDB Length = 403 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 73/440 (16%), Positives = 138/440 (31%), Gaps = 80/440 (18%) Query: 42 GPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDL--GGISTVVLNGYDVVKECL 99 G P PF AS P K + + L G ++ +V DV C Sbjct: 4 GAPSFPFS------RASGPEPPAEFAKLRAT-NPVSQVKLFDGSLAWLVTKHKDV---CF 53 Query: 100 VHQSEIFAD-RPCLPLFMKMTKMGGLLNSRY------GRGWVDHRRLAVNSFRYFGYGQK 152 V SE + R ++ + R + +F K Sbjct: 54 VATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFTP--EAVK 111 Query: 153 SFESKILEETKFFNDAIET--YKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM 210 + + I + ++ P D + V + + G F D ++ Sbjct: 112 NLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFN--DLEYLTQ 169 Query: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 N A ++ + D+L+ L+E+ V K Sbjct: 170 QNAIRTNGSSTA---------------------REASAANQELLDYLAILVEQRLVEPK- 207 Query: 271 QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYP 330 D + ++ + P + K + + L++AG T N++ + +A +P Sbjct: 208 -------DDIISKLCTEQVKPGN-IDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHP 259 Query: 331 NIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVR 390 + Q++ L + E+ R+ L I ED ++ Sbjct: 260 DQLAQLKANPSL------------------APQFVEELCRYHTASALAIKRTAKEDVMIG 301 Query: 391 GYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLG 450 + +I + S + DE+ + +P+ F+ R + F G C+ Sbjct: 302 DKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP-------LGFGFGDHRCIA 354 Query: 451 EHLARMEMFLFFTALLQRFH 470 EHLA+ E+ F+ L Q+F Sbjct: 355 EHLAKAELTTVFSTLYQKFP 374 >6A7J-A nrPDB Length = 411 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 72/433 (16%), Positives = 144/433 (33%), Gaps = 84/433 (19%) Query: 74 GEIFSLDL-GGISTVVLNGYDVVKECLVH--------------QSEIFADRPCLPLFMKM 118 G + ++L GG+ + + + L + EI AD PL + Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPAD---WPLIGLV 82 Query: 119 TKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY-KGRPF 177 +L G R L + + + I T + + G P Sbjct: 83 NPGRSMLTVD-GPDHRRLRTLVAQALTV--KRVEKLRAGIEALTNASLERLAALPAGEPV 139 Query: 178 DFKQLITNA-VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIG 236 D K N+ + E + D + ELF + Sbjct: 140 DLKAEFAYPLPMNVIS-----ELMGVDAADHPRLKELFEKFFSTQTPP------------ 182 Query: 237 ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFS 296 +++ + A + ++++E+ N L + A ++ + Sbjct: 183 -------EEVPQMMADLGTLFTKIVEEKKANPGDDLTSALIAA---------SEDGDHLT 226 Query: 297 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356 E ++ ++ +I AG ETT +++ + +A++P + +V +G+ W Sbjct: 227 DEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV---------LSGEIPW---- 273 Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-R 415 E V+ E LR+ + +ED V +PKG ++ + ++ DE+ + Sbjct: 274 -----EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGP 328 Query: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH 475 F R + + F G C G L+R+E + AL +RF Sbjct: 329 TAGDFDATRTPNR---------HIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLA 379 Query: 476 ELVPDLKPRLGMT 488 +L+ + +T Sbjct: 380 VPAAELRNKPIVT 392 >3R9C-A nrPDB Length = 418 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 70/385 (18%), Positives = 123/385 (31%), Gaps = 57/385 (14%) Query: 108 DRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFND 167 R + R L +F + E +I D Sbjct: 80 QRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVIKR--LEPEITALVDQLLD 137 Query: 168 AIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVF 227 A+ G F+ + + + G ++ F L + ++ + + Sbjct: 138 AV---DGPEFNLIDNLAYPLPVAVICRLLGVPIE-DEPKFSRASALLAAALDPFLALTGE 193 Query: 228 LYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 287 + F + + + D+L LI++ L V Sbjct: 194 TSDLFD-----------EQMKAGMWLRDYLRALIDERRRTPGEDLMSGLV---------A 233 Query: 288 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 + +++ +I + L+IAG ETT N++ A L M P + + Sbjct: 234 VEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSR----- 288 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 AV+ E +R+ V L + +D + +++PKG T++ L + Sbjct: 289 -------------ASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLLLLAAA 334 Query: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 H D P+ F P+R + + F G CLG LAR+E + AL Sbjct: 335 HRDPTIVGAPDRFDPDR---------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAA 385 Query: 468 RF---HLHFPHELVPDLKPRLGMTL 489 RF L E +L R TL Sbjct: 386 RFPEARLSGEPEYKRNLTLRGMSTL 410 >3WVS-A nrPDB Length = 401 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 63/359 (17%), Positives = 110/359 (30%), Gaps = 62/359 (17%) Query: 113 PLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172 P K + + RRL +F + K+ + D + Sbjct: 78 PRARKFNAQAKSMFNMDAPDHTRLRRLISKAFTI--RRVEELRPKVHDLAHRLIDDMLA- 134 Query: 173 KGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAF 232 KG P D + + G F E F + S S Sbjct: 135 KGEPADLVADYALPIPTTVICELLGVPFEDR--------EKFGRWTDAILSTSTLNPE-- 184 Query: 233 PWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPS 292 G+ +++ + ++ +I L ++A D Sbjct: 185 -------EGRVKRM-----ELVGYIGGIIAARRAQPADDLISGMIEA---------RDVQ 223 Query: 293 STFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSW 352 +++ L+ L+IAG ETT + + + + P ++ + +LI Sbjct: 224 DKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPELI--------- 274 Query: 353 DDKCKMPYTEAVLHEVLRFCNIVP-LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 + + E+ RF + ED V G + G V+ L + + D Sbjct: 275 ---------PSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDG 325 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + DPE +R + F G HCLG LAR+E+ ALL+R Sbjct: 326 LRFEDPEEIKLDR---------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERLP 375 >5Y1I-A nrPDB Length = 403 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 64/413 (15%), Positives = 121/413 (29%), Gaps = 67/413 (16%) Query: 78 SLDLGGISTVVLNGYDVVKECLVHQSEIFAD-RPCLPL----FMKMTKMGGLLNSRYGRG 132 + G VV D + L R P F ++ + Sbjct: 37 RIWDGSTPWVVTRHADQ-RALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 133 WVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITN 192 RR+ F ++ I + T D + +P D + + V Sbjct: 96 HGRIRRMVTLPFTARRI--EAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRVI 152 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV 252 + G YED +F + A + A Sbjct: 153 CEMLG--VPYEDREFLQ-QNNNAMIYRDTAQGDAQ--------------------KAAIA 189 Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312 +L L+ +R + + ++++ L+ AG Sbjct: 190 QAMYLKELVGTKLGDRGDDILSDL----------AVQVEAGEITQDDAAGIGMMLLGAGH 239 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 ETT N++ L + P +V+ D + E+LR+ Sbjct: 240 ETTANMIALGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLRYL 283 Query: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD-PEVFHPERFLDSSGY 431 I + +ED + G I G ++ L + ++D + + P+ R Sbjct: 284 TIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR------- 336 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR 484 A + F G CLG LAR+E+ + ++ LL+R + ++ + Sbjct: 337 -ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFK 388 >6FSH-A nrPDB Length = 398 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 67/411 (16%), Positives = 129/411 (31%), Gaps = 78/411 (18%) Query: 91 GYDVVKECLVHQSEIFADRPCLPLFMKMTKMG--------GLLNSRYGRGWVDHRRLAVN 142 G+ VV++ L + F+ R ++ G G L R L Sbjct: 47 GHAVVRQVLGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRHLLTP 105 Query: 143 SFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTY 202 F + +I E DA+E G P D +L + V + G Sbjct: 106 GFTQRRMRR--LAPRIEEIVTDRLDAMEQA-GPPADLIELFADEVPGAVLCELIGVPRDD 162 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIE 262 D ++L +++ + S ++ +L +I Sbjct: 163 RDM----FMKLCHGHLDASLS-------------------QKRRAALGDKFSRYLLAMIA 199 Query: 263 KASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWA 322 + + V + T + E L +L++AG + + ++ Sbjct: 200 RERKDPGDGFIGSIVA-----------EHGDTITDEELRGVCVQLMLAGDDNVSGMIGLG 248 Query: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382 +L + +P ++ + + + E++R+ + Sbjct: 249 VLALLRHPEQIAALRGD------------------DQSADRAVDELIRYLTVPYAPTPRT 290 Query: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS 442 ED +V I +G TV+ +L + D D + R V F Sbjct: 291 AVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT---------PVPHVAFG 341 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDL-----KPRLGMT 488 G HCLG L R+++ + +TAL +RF + ++ P G+T Sbjct: 342 HGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLT 392 >5XW2-A nrPDB Length = 419 Score = 188 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 78/445 (17%), Positives = 149/445 (33%), Gaps = 78/445 (17%) Query: 51 NIYSLAASSELPHVYMRKQS--QVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFAD 108 + + + K + VYG ++++ G + + + E F Sbjct: 34 HFWLYGRRPRQMVEFDEKMNAWNVYGYAEAIEVLGDPGTF--SSHMSRLLPMGADEAFT- 90 Query: 109 RPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDA 168 G L + R+L ++F + E +I T+ DA Sbjct: 91 -------------EGDLLQTDPPDHRELRKLVSHAFTPKVVAE--LEPRITALTQELLDA 135 Query: 169 IETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL 228 + + A++ + + E + D +H+ E + + + + V + Sbjct: 136 VADRD------TFDLMTALAYPLPVTVVAELLSIPSAD-RHLFEGWMTEI-VHSLGDVSM 187 Query: 229 YNAFPWIGILPFGKHQQLFRN----AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEM 284 +A +++F + ++L + + L ++A +D Sbjct: 188 EDA--------PEDQERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVD-- 237 Query: 285 DQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIM 344 + +++ L+IAG TTT ++ +L + YP +V+ + LI Sbjct: 238 -------GRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADRSLIP 290 Query: 345 GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNL 404 G L E +RF + V + AT+ D V G + V+ Sbjct: 291 GL------------------LEESMRFLSPV-AATYRATTRDVEVAGQRLSADQMVMVWF 331 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464 + + D + + +PE+F R + F G CLG LARME + Sbjct: 332 GAANRDARQFAEPELFDMTR---------GPNPHLGFGRGIHFCLGGPLARMEGRVALDH 382 Query: 465 LLQRF-HLHFPHELVPDLKPRLGMT 488 LL RF L+ E P P T Sbjct: 383 LLDRFPELYTDPERPPTFMPGFDTT 407 >4WPZ-A nrPDB Length = 397 Score = 188 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 63/367 (17%), Positives = 117/367 (31%), Gaps = 71/367 (19%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R+L +F ++ +I E D +ET RP D + + + Sbjct: 87 APEHTRLRKLVTKAFT--ARRVETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPV 143 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + G +D F G QQ+ Sbjct: 144 RVICELLGVPAGDQD--------------------------TFHAWSNALLGDWQQVVEK 177 Query: 250 AAV---VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGE 306 A + ++ LI N L + +D ST ++ +I Sbjct: 178 EAATVSLVNYFGELIAVKRENPADDLISELIAI---------SDGDSTLTEREIIALSIG 228 Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 ++ AG ETT N + ++ + P +++ + I + Sbjct: 229 ILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAI------------------PKAVD 270 Query: 367 EVLRFCNIVPLG--IFHATSEDAVV-RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 E+LRF + G I T+ + + G +P G V+ + + + D + + D E + Sbjct: 271 ELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVT 330 Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483 R + + F G HCLG LAR+E+ A+L R +L+ Sbjct: 331 R---------ENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRL 381 Query: 484 RLGMTLQ 490 + ++ Sbjct: 382 KSASIIR 388 >4TRI-A nrPDB Length = 407 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 77/430 (17%), Positives = 138/430 (32%), Gaps = 73/430 (16%) Query: 75 EIFSLDLGGISTV---VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR 131 +F G + + + E I D+P +P + M Sbjct: 35 PVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIRPDQPGMPYMIDMDD----------P 84 Query: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191 + R+L F K I DA+ DF + I + Sbjct: 85 QHLLRRKLVNAGFTRKRVMDKV--DSIGRLCDTLIDAVCER--GECDFVRDIAAPLPMAV 140 Query: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251 + G T D M+ +S+++ S+ V Q+L A Sbjct: 141 IGDMLGVLPTERD-----MLLKWSDDLVCGLSSHVD------------EAAIQKLMDTFA 183 Query: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311 +F +I K L V++ ++ S + ++F ++I G Sbjct: 184 AYTEFTKDVITKRRAEPTDDLFSVLVNSEVE---------GQRMSDDEIVFETLLILIGG 234 Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371 ETT + L + + + + ++DL+ G + E+LR+ Sbjct: 235 DETTRHTLSGGTEQLLRHRDQWDALVADVDLLPG------------------AIEEMLRW 276 Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431 + V + + D V G + G ++ S +FDE + DP+ F +R Sbjct: 277 TSPVK-NMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR------- 328 Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF-HLHFPHELVPDLKPRLGMTLQ 490 + V F G CLG LAR+E+ L +L+R L + L+P Sbjct: 329 --NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPA-NFVSG 385 Query: 491 PQPYLICAER 500 P+ + Sbjct: 386 PESMPVVFTP 395 >6A7I-A nrPDB Length = 411 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 64/382 (16%), Positives = 123/382 (32%), Gaps = 66/382 (17%) Query: 110 PCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI 169 PL +L G R L + + + I T + + Sbjct: 74 MDWPLIGLANPGRSMLTVD-GADHRRLRTLVAQALTVKRVER--LRAGIEALTNASLEKL 130 Query: 170 ETY-KGRPFDFKQLITNA-VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVF 227 G P D K N+ + E + D + ELF + Sbjct: 131 AALPAGEPVDLKAEFAYPLPMNVIS-----ELMGVDAADHPRLKELFEKFFSTQTPP--- 182 Query: 228 LYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 287 +++ + A + +++++ N L + A Sbjct: 183 ----------------EEVPQMMADLGALFTKIVDAKRTNPGDDLTSALIAA-------- 218 Query: 288 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 ++ + E ++ ++ +I AG ETT +++ + + +P + +V N Sbjct: 219 -SENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKV---------LN 268 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 G+ WD V+ E LR+ + +ED V +PKG +I + ++ Sbjct: 269 GEIGWD---------GVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGAL 319 Query: 408 HFDEKYW-RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 DE+ + F R + + F G C G L+R+E + AL Sbjct: 320 GRDEEQYGPTAGEFDATRTPNR---------HIAFGHGPHVCPGAALSRLEAGIALPALY 370 Query: 467 QRFHLHFPHELVPDLKPRLGMT 488 +RF DL+ + +T Sbjct: 371 ERFPELDLAVPASDLRNKPIVT 392 >5XJN-A nrPDB Length = 455 Score = 186 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 125/392 (31%), Gaps = 68/392 (17%) Query: 88 VLNGYDVVKECLVHQSEIFAD-------RPCLPLFMKMTKMGGL-----LNSRYGRGWVD 135 V+ YD +K E F+ R P ++ GG L++R Sbjct: 87 VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTR 145 Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195 R +A +F Y K+ E I + + D + + IT L + Sbjct: 146 IRAIAQKAFTPRRY--KALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILTL 203 Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255 G + DT + +S++ + P N + Sbjct: 204 IGADISMVDT-----YKRWSDSRAAMTWGDLSDEEQIP------------HAHNLVEYWQ 246 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 R++ A + L V A + + + L+ AG ETT Sbjct: 247 ECQRMVADAHAHGGDNLTADLVRA---------QQEGQEITDHEIASLLYSLLFAGHETT 297 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T ++ + +P + + LI A + EVLR+ + Sbjct: 298 TTLISNCFRVLLDHPEQWQAILENPKLI------------------PAAVDEVLRYSGSI 339 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 +G +D + G +I +G V+ + S + DE + + E F R A Sbjct: 340 -VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR--------ANA 390 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 + F G +CLG LA+++ + + + Sbjct: 391 REHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >6CVC-A nrPDB Length = 433 Score = 186 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 79/479 (16%), Positives = 151/479 (31%), Gaps = 71/479 (14%) Query: 29 QLLKQRRPMGFPPGPPGLP--FIGNIYSLAASSELPHVYMRKQSQV-----YGEIFSLDL 81 L R G PP L +G++ + + + I L Sbjct: 9 TGLLPRV-NGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGL 67 Query: 82 -GGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM----GGLLNSRYGRGWVDH 136 G L +D + EIF P + + + ++ G ++ Sbjct: 68 TAGKGHWALTKHDDIHFA-SRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLD-DPRHQRL 125 Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAI-ETYKGRPFDFKQLITNAVSNITNLII 195 R + +F + E+ + E A+ E + D + + + Sbjct: 126 RSIVSRAFTPKVVAR--IEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDM 183 Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255 G ED + ++F + L F + + + + Sbjct: 184 MG--IPEEDHE-----QIFHWTNVILGFGDPDLTTDFD-----------EFLQVSMAIGG 225 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 + + L + VN L V+A +D S + L++AG ETT Sbjct: 226 YATALADDRRVNHHGDLTTSLVEAEVD---------GERLSSSEIAMFFILLVVAGNETT 276 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 N + +L ++ YP+ + + + D + + E++R+ + V Sbjct: 277 RNAISHGMLALSRYPDERAKWWSDFDGLAA-----------------TAVEEIVRWASPV 319 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 + + S+D +RG + G V S + DE+ + DP F R + F Sbjct: 320 -VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFG-- 376 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPY 494 G CLG +LAR E+ + F L ++ E L + ++ P Sbjct: 377 ------GGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPV 429 >5GWE-A nrPDB Length = 405 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 125/392 (31%), Gaps = 68/392 (17%) Query: 88 VLNGYDVVKECLVHQSEIFAD-------RPCLPLFMKMTKMGGL-----LNSRYGRGWVD 135 V+ YD +K E F+ R P ++ GG L++R Sbjct: 37 VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTR 95 Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195 R +A +F Y K+ E I + + D + + IT L + Sbjct: 96 IRAIAQKAFTPRRY--KALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILTL 153 Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255 G + DT + +S++ + P N + Sbjct: 154 IGADISMVDT-----YKRWSDSRAAMTWGDLSDEEQIP------------HAHNLVEYWQ 196 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315 R++ A + L V A + + + L+ AG ETT Sbjct: 197 ECQRMVADAHAHGGDNLTADLVRA---------QQEGQEITDHEIASLLYSLLFAGHETT 247 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375 T ++ + +P + + LI A + EVLR+ + Sbjct: 248 TTLISNCFRVLLDHPEQWQAILENPKLI------------------PAAVDEVLRYSGSI 289 Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435 +G +D + G +I +G V+ + S + DE + + E F R A Sbjct: 290 -VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR--------ANA 340 Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 + F G +CLG LA+++ + + + Sbjct: 341 REHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >2WM5-A nrPDB Length = 435 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 74/475 (15%), Positives = 148/475 (31%), Gaps = 70/475 (14%) Query: 34 RRPMGFPPGPPGLP--FIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG 91 R G PP + +G++ A ++ + F + V NG Sbjct: 16 TRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNG 75 Query: 92 YDVVKE---CLV--HQSEIFADRPCLPLFMKMTKM----GGLLNSRYGRGWVDHRRLAVN 142 + + + +IF+ P + + + ++ G ++ R + Sbjct: 76 HWALTKYDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLD-DPRHQRLRSIVSR 134 Query: 143 SFRYFGYGQKSFESKILEETKFFNDAI-ETYKGRPFDFKQLITNAVSNITNLIIFGERFT 201 +F + E+ + + ++ R D + + + G Sbjct: 135 AFTPKVVAR--IEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMG--IP 190 Query: 202 YEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLI 261 D +F + L F + + +A + + + L Sbjct: 191 KADHQ-----RIFHWTNVILGFGDPDLATDFD-----------EFMQVSADIGAYATALA 234 Query: 262 EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRW 321 E VN L V+A +D S + L++AG ETT N + Sbjct: 235 EDRRVNHHDDLTSSLVEAEVD---------GERLSSREIASFFILLVVAGNETTRNAITH 285 Query: 322 AILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFH 381 +L ++ YP + + + D + + E++R+ + V + + Sbjct: 286 GVLALSRYPEQRDRWWSDFDGL-----------------APTAVEEIVRWASPV-VYMRR 327 Query: 382 ATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPF 441 ++D +RG + G V S + DE + DP F R + F Sbjct: 328 TLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------NPNPHLGF 378 Query: 442 -SLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL 495 G CLG +LAR E+ + F L ++ E L + ++ P Sbjct: 379 GGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVT 433 >4TX3-A nrPDB Length = 404 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 69/411 (16%), Positives = 127/411 (30%), Gaps = 78/411 (18%) Query: 91 GYDVVKECLVHQSEIFADRPCLPLFMKMTKMG--------GLLNSRYGRGWVDHRRLAVN 142 G+ VV++ L F+ R ++ G G L R L Sbjct: 53 GHAVVRQVLGDHKR-FSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTP 111 Query: 143 SFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTY 202 F + +I E DA+E G P D +L + V + G Sbjct: 112 GFTQRRMRR--LAPRIEEIVTDRLDAMEQA-GPPADLIELFADEVPGAVLCELIGVP--- 165 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIE 262 D + ++ + AA F L+ Sbjct: 166 RDDQAMFLQLCHRHLDASLSA-----------------------RKRAAAGEAFARYLVA 202 Query: 263 KASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWA 322 + RK D ++ + + T + E L +L++AG + + ++ Sbjct: 203 MMARERK-----DPGDGFIGSIVA---EHGDTITDEELRGVCVQLMLAGDDNVSGMIGLG 254 Query: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382 +L + +P ++ + + + E++R+ + Sbjct: 255 VLALLRHPEQIAALRGD------------------DQSADRAVDELIRYLTVPYAPTPRT 296 Query: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS 442 ED +V I +G TV+ +L + D D + R V F Sbjct: 297 AVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT---------PVPHVAFG 347 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDL-----KPRLGMT 488 G HCLG L R+++ + +TAL +RF + ++ P G+T Sbjct: 348 HGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLT 398 >5Z9I-A nrPDB Length = 398 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 70/433 (16%), Positives = 129/433 (29%), Gaps = 69/433 (15%) Query: 50 GNIYSLAASSELPHVYMRKQS--QVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFA 107 G+ + + Y + VYG S + V D ++ + E Sbjct: 14 GHFWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVF--SSDTMRLDPIKLDEAIV 71 Query: 108 DRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFND 167 G R L ++F + ES++ D Sbjct: 72 --------------EGDFAHTDPPKHRRLRGLVDHAFTPSLVAK--MESRVHGIIHELLD 115 Query: 168 AIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVF 227 +E FD + I + G + F+ ++ + E S Sbjct: 116 GVEGK--SQFDLVAEFAAPLPLIMISDLLGVP-ESDRALFRQWMDKMLDGSEKFESPETV 172 Query: 228 LYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 287 L + + + D+ ++ + L V A +D Sbjct: 173 LEQE---------EELHKELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVD----- 218 Query: 288 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 + + L++ G TT ++ +L + + + +V+ + L+ Sbjct: 219 ----GQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRSLV---- 270 Query: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 A+L E +R+ + + G+ AT+ + V G IPK ++ + Sbjct: 271 --------------PALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAA 315 Query: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 + DE+ + P+VF R A + F G CLG LARME LL Sbjct: 316 NRDERQFEKPDVFDAGR---------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLD 366 Query: 468 RFHLHFPHELVPD 480 R P Sbjct: 367 RLPTLRADPANPP 379 >4MM0-A nrPDB Length = 399 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 66/405 (16%), Positives = 131/405 (32%), Gaps = 66/405 (16%) Query: 83 GISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM--GGLLNSRYGRGWVDHRRLA 140 G ++ Y+ V+ L F+ R LP ++T+M ++ + RRL Sbjct: 44 GDPGFLVTRYEDVRFVLSD--PRFSVRQDLPGAPRLTEMTFESVMTTDP-PVHTRLRRLL 100 Query: 141 VNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERF 200 F + ++ E + D +E KG P D + + + G Sbjct: 101 SRDFTARRIER--MRPRLEEIAEGLLDEMEK-KGAPADIVESLAVPFPITVICELLGVPM 157 Query: 201 TYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRL 260 + F+ + Y+ W + +L L Sbjct: 158 -VDVARFRGWADTMVSLTG---------YSMEDWTA------------ARDALESYLDGL 195 Query: 261 IEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLR 320 + N L V + + ++ L++AG E +N L Sbjct: 196 VAAKRENPGSDLLSALV---------ATAAEDNELTDHDVRSLSLILLLAGYEPASNQLG 246 Query: 321 WAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF 380 ++L + +P+ +++++ L+ + + E++R+ +F Sbjct: 247 SSVLTLLRFPDRLAELRRDPGLL------------------PSAVEELMRYAPAGDGALF 288 Query: 381 HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVP 440 T ED + IP + V+ + + ++D + + DP +R Sbjct: 289 RVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR---------PDNQHTA 339 Query: 441 FSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 G CLG LAR+E+ + ALL+RF L+ Sbjct: 340 LGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSS 384 >3P3Z-A nrPDB Length = 416 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 74/351 (21%), Positives = 126/351 (35%), Gaps = 60/351 (17%) Query: 135 DHRRLAVNSFRYFGYGQ-KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 DHRRL + F + + + + + D + FDF Q + + + Sbjct: 107 DHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQGD---FDFVQHFPHPLPALVMC 163 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 + G DT + IE N+ LA S + ++ + + Sbjct: 164 QLLGFPLEDYDTVGRLSIET---NLGLALSNDQDIL--------------VKVEQGLGRM 206 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 +D+L IEK V L V A+ D + L V +++AG E Sbjct: 207 FDYLVAAIEKRKVEPGDDLTSDIVRAFHDGV----------LDDYELRTLVATVLVAGYE 256 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 TT + L A+ A +P+ ++++ +L + EVLR+ Sbjct: 257 TTNHQLALAMYDFAQHPDQWMKIKENPEL------------------APQAVEEVLRWSP 298 Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 +P+ +ED V G IP GT V + H D + + D + F Sbjct: 299 TLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT--------VK 350 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR 484 ++ + F G CLG LAR+E+ AL R P ++ ++ R Sbjct: 351 REAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD---PPQIAGEITWR 398 >5FOI-A nrPDB Length = 408 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 71/410 (17%), Positives = 145/410 (35%), Gaps = 69/410 (16%) Query: 83 GISTVVLNGYDVVKECLV--HQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLA 140 G T +++ Y+ V+ LV + +P L + RR+ Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 141 VNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITN-AVSNITNLIIFGER 199 +++F ++ +I + D + + P D + + + ++ Sbjct: 115 ISAFSVRQV--ETMRPEIEKIVDGILDRLLALE-PPVDILTHLALPMSTQVICHLL---G 168 Query: 200 FTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSR 259 YED +F F E ELA+ + + + ++L Sbjct: 169 VPYEDREF------FQERSELASRPNDD-----------------RSMPALIELVEYLDG 205 Query: 260 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVL 319 L+ + + L A + + +G+ + + L+ + L+ AG ET+ N + Sbjct: 206 LVRTKTAHPDTGL---LGTAVTERLLKGE------ITHQELVNNAVLLLAAGHETSANQV 256 Query: 320 RWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGI 379 ++L + +P +++++ +L + E+LR+ +I G+ Sbjct: 257 TLSVLTLLRHPETAAELREQPEL------------------MPNAVDELLRYHSIAD-GL 297 Query: 380 FHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALV 439 A + D V+ ++I G +I L S + D + F R V Sbjct: 298 RRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR---------PARHHV 348 Query: 440 PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 489 F G CLG++LAR+EM + L +R + L+ R G + Sbjct: 349 AFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPI 398 >2XKR-A nrPDB Length = 398 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 74/402 (18%), Positives = 130/402 (32%), Gaps = 81/402 (20%) Query: 101 HQSEIFAD----RPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFES 156 Q E+F++ RP P M M + R+L F K E+ Sbjct: 54 RQPELFSNAGGIRPDQPALPMMIDMD-------DPAHLLRRKLVNAGFTRKRVKDK--EA 104 Query: 157 KILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSE 216 I DA+ DF + + + + G R + + M +S+ Sbjct: 105 SIAALCDTLIDAVCER--GECDFVRDLAAPLPMAVIGDMLGVR-----PEQRDMFLRWSD 157 Query: 217 NVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHF 276 ++ S + Q A DF I + L Sbjct: 158 DLVTFLS------------SHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVL 205 Query: 277 VDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336 V + +D S + L+ ++I G ETT + L + + + Sbjct: 206 VSSEVD---------GERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLL 256 Query: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396 Q++ L+ G + E+LR+ V + + D G ++ Sbjct: 257 QRDPSLLPG------------------AIEEMLRWTAPVK-NMCRVLTADTEFHGTALCA 297 Query: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456 G ++ S +FDE + +PE F +R + + F G CLG LAR+ Sbjct: 298 GEKMMLLFESANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARL 348 Query: 457 EMFLFFTALLQRFHLHFPHELVPDLKP---RLGMTLQPQPYL 495 E+ L +L+R PDL+ + L+P ++ Sbjct: 349 ELSLMTERVLRRL---------PDLRLVADDSVLPLRPANFV 381 >2WIO-A nrPDB Length = 431 Score = 181 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 63/395 (15%), Positives = 119/395 (30%), Gaps = 62/395 (15%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWV 134 ++ G + + V+ L + F+ P + G + Sbjct: 62 PVWQDRYG---VWHVFRHADVQTVLRDTA-TFSSDPTRVIEGASPTPGMIHEIDP-PEHR 116 Query: 135 DHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLI 194 R++ ++F E +I + T+ G FD ++ + Sbjct: 117 ALRKVVSSAFTPRTISD--LEPRIRDVTRSLL----ADAGESFDLVDVLAFPLPVTIVAE 170 Query: 195 IFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVY 254 + G ++ A + + + +++ + Sbjct: 171 LLG----------LPPMDHEQFGDWSGALVDIQMDD------PTDPALAERIADVLNPLT 214 Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314 +L + + L V A +D E L++AG T Sbjct: 215 AYLKARCAERRADPGDDLISRLVLAEVD---------GRALDDEEAANFSTALLLAGHIT 265 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 TT +L + + +P ++ I A++ EVLR+ Sbjct: 266 TTVLLGNIVRTLDEHPAHWDAAAEDPGRI------------------PAIVEEVLRYRPP 307 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 P + T++ V G IP V T + S + D DP+ F P R + Sbjct: 308 FP-QMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRK-------SG 359 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 469 A + F G CLG LAR+E + ++ RF Sbjct: 360 GAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >6GK6-A nrPDB Length = 411 Score = 181 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 65/390 (16%), Positives = 123/390 (31%), Gaps = 72/390 (18%) Query: 86 TVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFR 145 +L ++++ + R PL + T M + R + +F Sbjct: 54 VELLKDPRLIRDF--RKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFS 111 Query: 146 YFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDT 205 + +I E DA+ + + + + G + Sbjct: 112 PRMM--EGLRPRIQEIADGLIDAVIDRR--RMELIADFAFPLPTAVIAELLGLPVE-DRG 166 Query: 206 DFQHMIELFSENVELAASASVFLYNAFPWIGIL--PFGKHQQLFRNAAVVYD---FLSRL 260 F+ W IL P + + R VV + + L Sbjct: 167 RFRR------------------------WTKILLAPAKDREFVERAQPVVEEFAAYFRAL 202 Query: 261 IEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLR 320 + + L + A + S L V L++AG ETT +++ Sbjct: 203 ADARRKAPRDDLISGLLLA---------EEQEHKLSPAELSSMVFLLLVAGHETTVHLIA 253 Query: 321 WAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF 380 +L + +P + ++ ++ L+ + + E LR L Sbjct: 254 SGMLLLLSHPAERRRLDEDPGLV------------------GSAVEEALRCEGPAELSTI 295 Query: 381 HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVP 440 + ED + G +P G V L + + D +++ DP+ F R + + Sbjct: 296 RWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPNR---------HIG 346 Query: 441 FSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 F G CLG LAR+E + F+ LL+R Sbjct: 347 FGGGIHFCLGAMLARIEAAIAFSTLLRRLP 376 >6B11-A nrPDB Length = 440 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 73/406 (17%), Positives = 138/406 (33%), Gaps = 68/406 (16%) Query: 83 GISTVVLNGYDVVKECLVH-QSEIFADR-PCLPLFMKMTKMGGLLNSRYGRGWVDHRRLA 140 G +++ D V+ L + I + P L + L + R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHF 145 Query: 141 VNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITN-AVSNITNLIIFGER 199 + F + + + D + +G D + + ++ Sbjct: 146 IPEF--GLRRVRELRPSVEQIVTGLLDDLTA-RGDEADLLADFALPMATQVICRLL---D 199 Query: 200 FTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSR 259 YED D+ F E E A + ++ + D+L R Sbjct: 200 IPYEDRDY------FQERTEQATRPAA----------------GEEALEALLELRDYLDR 237 Query: 260 LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVL 319 LI + + D L M S +++ + L+ AG ETT +++ Sbjct: 238 LI-------SGKTGRESGDGMLGSMVAQARGGG--LSHADVLDNAVLLLAAGHETTASMV 288 Query: 320 RWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGI 379 ++L + +P ++ L+ G + E+LR+ +I G+ Sbjct: 289 TMSVLVLLQHPTAWRELTVNPGLLPG------------------AVDELLRYLSIAD-GL 329 Query: 380 FHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALV 439 + + D + G++I G ++ L + + DE + +PE F R V Sbjct: 330 RRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR---------SARRHV 380 Query: 440 PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 F G CLG++LARME+ + A+L+R P V L+ + Sbjct: 381 AFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKS 426 >1LG9-A nrPDB Length = 398 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 65/402 (16%), Positives = 122/402 (30%), Gaps = 73/402 (18%) Query: 92 YDVVKECLVHQSEIFADRPCLPLFMKMTKMG--------GLLNSRYGRGWVDHRRLAVNS 143 + VV++ + + F+ R ++ G G L RR Sbjct: 48 HAVVRQVMGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRKLTPG 106 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 F + I + D +E G P D + + V + G Sbjct: 107 FTLRKM--QRMAPYIEQIVNDRLDEMERA-GSPADLIAFVADKVPGAVLCELVGVPRDDR 163 Query: 204 DTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEK 263 D ++L +++ + S ++ +L +I + Sbjct: 164 DM----FMKLCHGHLDASLS-------------------QKRRAALGDKFSRYLLAMIAR 200 Query: 264 ASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAI 323 + V Y + E L ++++AG + + ++ + Sbjct: 201 ERKEPGEGMIGAVVAEY-----------GDDATDEELRGFCVQVMLAGDDNISGMIGLGV 249 Query: 324 LFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHAT 383 L M +P + + + + E++R+ + Sbjct: 250 LAMLRHPEQIDAFRGDEQS------------------AQRAVDELIRYLTVPYSPTPRIA 291 Query: 384 SEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSL 443 ED + G I KG +VI +L + + D D + R + V F Sbjct: 292 REDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR---------EPIPHVAFGH 342 Query: 444 GRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 G HCLG LAR+E+ FT L +RF + D + RL Sbjct: 343 GVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRL 384 >1GWI-A nrPDB Length = 411 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 68/419 (16%), Positives = 131/419 (31%), Gaps = 70/419 (16%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLV----HQSEIFADRPCLPLFMKMTKMGGLLNSRYG 130 ++++ + +L +VK+ V + EI AD PL +L G Sbjct: 42 PVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPAD---WPLIGLANPGRSMLTVD-G 97 Query: 131 RGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNI 190 R L + + +I E T D + G D K + Sbjct: 98 AEHRRLRTLVAQALTV--RRVEHMRGRITELTDRLLDELPA-DGGVVDLKAAFAYPLPMY 154 Query: 191 TNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNA 250 + G E+ + LF + +++ Sbjct: 155 VVADLMG----IEEARLPRLKVLFEKFFSTQTPP-------------------EEVVATL 191 Query: 251 AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 310 + ++ + L + A ++ + ++ ++ ++ A Sbjct: 192 TELASIMTDTVAAKRAAPGDDLTSALIQA---------SENGDHLTDAEIVSTLQLMVAA 242 Query: 311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 370 G ETT +++ A++ ++ +P + V +G+ W AV+ E LR Sbjct: 243 GHETTISLIVNAVVNLSTHPEQRALV---------LSGEAEWS---------AVVEETLR 284 Query: 371 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-RDPEVFHPERFLDSS 429 F + +ED V IP G +I + ++ DE+ + F R Sbjct: 285 FSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRT---- 340 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT 488 + F G C G L+RME + AL RF +L+ + +T Sbjct: 341 ----SGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVT 395 >5DQN-A nrPDB Length = 426 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 66/355 (18%), Positives = 115/355 (32%), Gaps = 73/355 (20%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R++ F G+ E ++ + DF + ++ + Sbjct: 104 APQHTRLRKIISRGFTPRAIGR--LEDELRSRAQKIAQTAAAQG--AGDFVEQVSCELPL 159 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + G D F+ E+ + A + + Sbjct: 160 QAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSSF------------------ 201 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 + + ++ E+ +VN + ++A +D S + F V L + Sbjct: 202 --ELISYAMKMAEERAVNPTEDIVTKLIEADID---------GEKLSDDEFGFFVVMLAV 250 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG ETT N + ++ A P+ +KE E E++ Sbjct: 251 AGNETTRNSITHGMIAFAQNPDQWELYKKE--------------------RPETAADEIV 290 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R+ V ED + G I KG V+ + S +FDE+ + DP F+ R + Sbjct: 291 RWATPVS-AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNP- 348 Query: 430 GYFAKKEALVPFSL-GRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483 V F G +C+G +LARM + L F A+ PDLKP Sbjct: 349 --------HVGFGGTGAHYCIGANLARMTINLIFNAIADNM---------PDLKP 386 >3S79-A nrPDB Length = 503 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 87/437 (19%), Positives = 167/437 (38%), Gaps = 28/437 (6%) Query: 41 PGPPGLPFIGNIYSLAASSELPHVYMRKQSQV-YGEIFSLDLGGISTVVLNGYDVVKECL 99 PGP IG + S + YGE + + G T++++ + + Sbjct: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 Query: 100 VHQSEIFADRPCLPLFMKMTKM--GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157 H ++ R L ++ M G++ + W R + + G G + Sbjct: 108 KH--NHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTV 163 Query: 158 ILEETKFFNDAIET--YKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFS 215 E K D +E + D L+ + + +N + E + F Sbjct: 164 CAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLD-ESAIVVKIQGYFD 222 Query: 216 ENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH 275 L +F W+ +++ ++ + D + LI + R+ + Sbjct: 223 AWQALLIKPDIFFK--ISWL-------YKKYEKSVKDLKDAIEVLIAEKR--RRISTEEK 271 Query: 276 FVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQ 335 + + + ++EN+ + E++IA +T + L + + +A +PN++ Sbjct: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 Query: 336 VQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIP 395 + KEI ++G DD K+ E ++E +R+ +V L + ED V+ GY + Sbjct: 332 IIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVK 389 Query: 396 KGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLAR 455 KGT +I N+ +H E ++ P F E F PF G R C G+++A Sbjct: 390 KGTNIILNIGRMHRLE-FFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAM 444 Query: 456 MEMFLFFTALLQRFHLH 472 + M LL+RFH+ Sbjct: 445 VMMKAILVTLLRRFHVK 461 >1CPT-A nrPDB Length = 428 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 66/392 (16%), Positives = 126/392 (32%), Gaps = 53/392 (13%) Query: 79 LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR 138 + +G + N E L Q+ R + + L S +R Sbjct: 61 MQIGKQPGLFSNAEG--SEILYDQNNEAFMR---SISGGCPHVIDSLTSMDPPTHTAYRG 115 Query: 139 LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGE 198 L +N F+ + E I + + + G DF + G Sbjct: 116 LTLNWFQPASIRK--LEENIRRIAQASVQRLLDFDG-ECDFMTDCALYYPLHVVMTALG- 171 Query: 199 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 258 +D M++L + + + ++ A YD+ + Sbjct: 172 -VPEDDEPL--MLKLTQDFFGVHEPDEQAVAAPRQSAD----EAARRFHETIATFYDYFN 224 Query: 259 RLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNV 318 K + ++ LD + + + + AG +TT++ Sbjct: 225 GFTVDRRSCPKDDVMSLLANSKLD---------GNYIDDKYINAYYVAIATAGHDTTSSS 275 Query: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 AI+ ++ P + + LI ++ E +R+ V Sbjct: 276 SGGAIIGLSRNPEQLALAKSDPALI------------------PRLVDEAVRWTAPVK-S 316 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438 D VRG +I +G ++ + S + DE+ + +P+ F RF + Sbjct: 317 FMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNR---------H 367 Query: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + F G CLG+HLA++EM +FF LL + Sbjct: 368 LGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >4Z5Q-A nrPDB Length = 423 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 71/438 (16%), Positives = 130/438 (29%), Gaps = 85/438 (19%) Query: 40 PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVY------GEIFSLDL-GGISTVVLNGY 92 P P PF G+ + SQ Y G+ + L G ++ Y Sbjct: 32 KPAPVAYPFTGS-------------EGLELSQSYAKLFEDGDPIRVQLPFGEPAWLVTRY 78 Query: 93 DVVKECLVHQ--SEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYG 150 D + L + S A + P +L R L +F Sbjct: 79 DDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDP-PDHTRLRTLVSKAFTPRRIE 137 Query: 151 QKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM 210 K + I E ++ G P + A+ + G Sbjct: 138 SK--RAWIGELAAGLVADMKAG-GAPAELVGSYALAIPVTVICELLGVPEDDR------- 187 Query: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 L ++ ++ + + L+++ + Sbjct: 188 ---------------TRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRD 232 Query: 271 QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYP 330 L ++A D ++ LI ++I G ETT + + + + Sbjct: 233 DLTSALIEA---------RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRR 283 Query: 331 NIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGI-FHATSEDAVV 389 + ++ + + I A + E+LRF GI ED V Sbjct: 284 ELWTRLCADPEAI------------------PAAVEELLRFVPFAANGISPRYALEDMTV 325 Query: 390 RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCL 449 G + +G VI + +V+ D + + + +R + + F G HCL Sbjct: 326 GGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADNR---------HMVFGHGAHHCL 376 Query: 450 GEHLARMEMFLFFTALLQ 467 G HLAR+E+ AL++ Sbjct: 377 GAHLARVELQEALKALVE 394 >6F0B-A nrPDB Length = 395 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 72/404 (17%), Positives = 129/404 (31%), Gaps = 62/404 (15%) Query: 83 GISTVVLNGYDVVKECLVHQS-EIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAV 141 G V +GY+ V+ L + + RP + DHRRL Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 142 NSFRYFGYG-QKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERF 200 R F + I E + D + P D + V++ +F Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGL-AETAPPQDMLEAFAVPVAS---ATVF-RLL 151 Query: 201 TYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRL 260 D + V S + ++FR ++ L Sbjct: 152 GIPAEDRALLTRCVKGVVSAVGSED----------------EGAEVFRTLGE---YIGGL 192 Query: 261 IEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLR 320 ++ S + L + V + I + LI+ G +TT + + Sbjct: 193 VQDPSELPEDSLIRRLVTG---------PYQEKQLTFHETIGVILMLIVGGYDTTASTIS 243 Query: 321 WAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF 380 +++ AL P V + + I ++ E+LR+ + LG+ Sbjct: 244 LSLVSYALQPEKFSVVHEHPERI------------------PLLVEELLRYHTVSQLGLG 285 Query: 381 HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVP 440 +ED V G ++ G V+ L + DE + +P+ +R V Sbjct: 286 RIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR---------PSVPHVG 336 Query: 441 FSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR 484 F G C+G+ LAR+E+ A+++R + DL R Sbjct: 337 FGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFR 380 >6M7L-A nrPDB Length = 404 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 77/422 (18%), Positives = 132/422 (31%), Gaps = 83/422 (19%) Query: 74 GEIFSLDL--GGISTVVLNGYDVVKECLVHQSEIFADRPCLPLF--MKMTKMGGLLNSRY 129 G + + L G GYDVV+E L E F R F +M G LL Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGS--EKFDKRVIGTHFNHQEMALPGNLLQLDP 105 Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 RR+ ++ ++ E ++ D + G P +F + + ++ Sbjct: 106 -PEHTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTM-ASTGPPVEFLREVAGPMAA 161 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 G D +I L + G ++ N Sbjct: 162 RVACEFLGIPLD----DRGELIRLTAHR-----------------------GGKRRRVLN 194 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 ++ L + + + D + S E L ++ Sbjct: 195 GHAYLAYMRELAARLRRDPGD-----------GMLGMVARDHGADISDEELAGLCAVVMN 243 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 + E T + L L + +P +++ +L E + E++ Sbjct: 244 SSVEQTESCLAAGTLLLLEHPEQFALLRERPEL------------------GEQAVEEIV 285 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHF-DEKYWRDPEVFHPERFLDS 428 R+ ++ +ED + G I KG V +L + + D + F R Sbjct: 286 RYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR---- 337 Query: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF---HLHFPHELVPDLKPRL 485 K+ V F G HCLG LARME+ + FT L+ RF P E + P Sbjct: 338 -----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRPPSS 392 Query: 486 GM 487 + Sbjct: 393 NV 394 >2X9P-A nrPDB Length = 404 Score = 171 bits (434), Expect = 6e-43, Method: Composition-based stats. Identities = 75/442 (16%), Positives = 144/442 (32%), Gaps = 76/442 (17%) Query: 53 YSLAASSELPHVYMRKQSQVYGEIFSLDL-GGISTVVLNGYDVVKECLVHQ--SEIFADR 109 +L L + + Q G I + G ++ + +K+ L + D Sbjct: 18 LNLEPPKMLKLSPLLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDP 77 Query: 110 PCLPLFMKMTKMGGLLN-SRYGRGWVDH---RRLAVNSFRYFGYGQKSFESKILEETKFF 165 P +++ + L++ + G H RRL F + + K+ E Sbjct: 78 PSAAQYVRSPFLDLLISDADAESGRRQHAETRRLLTPLFSARRVLE--MQPKVEEAADTL 135 Query: 166 NDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASAS 225 DA +G P D +T + + G + ++ Sbjct: 136 LDAFIA-QGPPGDLHGELTVPFALTVLCEVIGVP-PQRRAELTTLL-------------- 179 Query: 226 VFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMD 285 GI + R ++ +++ L+E P + D Sbjct: 180 ---------AGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLND------- 223 Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 +++ + L+ AG ++ +++ ++ +A +P+ + + D++ Sbjct: 224 -------GELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMA- 275 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIV-PLGIFHATSEDAVVRGYSIPKGTTVITNL 404 + EVLR + SED G +I G V+ +L Sbjct: 276 -----------------RAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDL 318 Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464 +FDE+ + PE F R + + F G HC+G LAR+E+ FT Sbjct: 319 GLPNFDERAFTGPEEFDAARTPNP---------HLTFGHGIWHCIGAPLARLELRTMFTK 369 Query: 465 LLQRFHLHFPHELVPDLKPRLG 486 L R P V L+ + G Sbjct: 370 LFTRLPELRPELPVEQLRLKEG 391 >3IVY-A nrPDB Length = 433 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 64/357 (17%), Positives = 110/357 (30%), Gaps = 73/357 (20%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R++ F G+ ++ E + DF + ++ + Sbjct: 121 APHHTRLRKIISRGFTPRAVGR--LHDELQERAQKIAAEAAAA--GSGDFVEQVSCELPL 176 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + G E+ S + P H + Sbjct: 177 QAIAGLLGVP---------------QEDRGKLFHWSNEMTGNED-----PEYAHIDPKAS 216 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 +A + + ++ E+ + N + + A +D S + F V L + Sbjct: 217 SAELIGYAMKMAEEKAKNPADDIVTQLIQADID---------GEKLSDDEFGFFVVMLAV 267 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG ETT N + ++ A +P+ K E E++ Sbjct: 268 AGNETTRNSITQGMMAFAEHPDQWE--------------------LYKKVRPETAADEIV 307 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R+ V D + G I KG V+ S +FDE+ ++DP F+ R Sbjct: 308 RWATPV-TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR----- 361 Query: 430 GYFAKKEALVPFSL-GRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 V F G +C+G +LARM + L F A+ PDLKP Sbjct: 362 ----NPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHM---------PDLKPIS 405 >3NC3-A nrPDB Length = 441 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 66/384 (17%), Positives = 129/384 (33%), Gaps = 51/384 (13%) Query: 88 VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYF 147 ++ Y V+ L +IF + + + + +L +G+ RR+ V SF Sbjct: 78 FISRYHDVRYIL-QHPDIFTTKSLVERAEPVMRGP-VLAQMHGKEHSAKRRIVVRSF--I 133 Query: 148 GYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDF 207 G I + + A +G+ D + + + G D + Sbjct: 134 GDALDHLSPLIKQNAENLL-APYLERGKS-DLVNDFGKTFAVCVTMDMLG--LDKRDHE- 188 Query: 208 QHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVN 267 + + + I P + L+ + + +L +I++ VN Sbjct: 189 ------------KISEWHSGVADFITSISQSPEARAHSLW-CSEQLSQYLMPVIKERRVN 235 Query: 268 RKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327 L + + M S ++++ + +++A TE L I + Sbjct: 236 PGSDLISILCTSEYEGM---------ALSDKDILALILNVLLAATEPADKTLALMIYHLL 286 Query: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387 P V + L+ + E LR+ V L I S+D Sbjct: 287 NNPEQMNDVLADRSLV------------------PRAIAETLRYKPPVQL-IPRQLSQDT 327 Query: 388 VVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF-LDSSGYFAKKEALVPFSLGRR 446 VV G I K T V + + + D + + P+VF+ R L F+ + F G Sbjct: 328 VVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIH 387 Query: 447 HCLGEHLARMEMFLFFTALLQRFH 470 +C+G A+ E+ + +L + Sbjct: 388 NCVGTAFAKNEIEIVANIVLDKMR 411 >3MGX-A nrPDB Length = 415 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 63/387 (16%), Positives = 114/387 (29%), Gaps = 84/387 (21%) Query: 103 SEIFADR-------PCLPLF------------MKMTKMGGLLNSRYGRGWVDHRRLAVNS 143 +F+ R P PL G ++ R+L Sbjct: 65 WSVFSHRACAAVLAPSAPLTSEYGMMIGFDRDHPDNSGGRMMVVSEHEQHRKLRKLVGPL 124 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 + ++ E + G D I + I G E Sbjct: 125 LSRA--AARKLAERVRIEVGDVLGRV--LDGEVCDAATAIGPRIPAAVVCEILGVPAEDE 180 Query: 204 DTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEK 263 D ++L A F + + + + LI Sbjct: 181 DM-----------LIDLTNHAFGGEDELFDGMTP---------RQAHTEILVYFDELITA 220 Query: 264 ASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAI 323 L V + ++++ + ++I G ETT + + A+ Sbjct: 221 RRKEPGDDLVSTLVTD-------------DDLTIDDVLLNCDNVLIGGNETTRHAITGAV 267 Query: 324 LFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHAT 383 +A P + ++ + + V+ EVLR+ + + + T Sbjct: 268 HALATVPGLLTALRDGSADV------------------DTVVEEVLRWTSPA-MHVLRVT 308 Query: 384 SEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSL 443 + D + G +P GT V+ L + + D + DP+ F P R K + F Sbjct: 309 TADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR---------KPNRHITFGH 359 Query: 444 GRRHCLGEHLARMEMFLFFTALLQRFH 470 G HCLG LAR+E+ + L +R Sbjct: 360 GMHHCLGSALARIELSVVLRVLAERVS 386 >3A1L-A nrPDB Length = 425 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 108/338 (31%), Gaps = 57/338 (16%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 + R L F +I E D + + D + + Sbjct: 103 PPHHTELRSLLTTEFSPSIVT--GLRPRIAELASALLDRLRAQR--RPDLVEGFAAPLPI 158 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 + + G E A+ + + Sbjct: 159 LVISALLG----------------IPEEDHTWLRANAVALQEASTTRARDGRGYARAEAA 202 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 + + R +++ + + L V A D S S + ++ + L+ Sbjct: 203 SQEFTRYFRREVDRRGGDDRDDLLTLLVRA---------RDTGSPLSVDGIVGTCVHLLT 253 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG ETTTN L A+L + + ++ +++ + T A + E++ Sbjct: 254 AGHETTTNFLAKAVLTLRAHRDVLDELRTTPES------------------TPAAVEELM 295 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R+ V + ED + + IP+G+ V+ L S + D + DP+V R + Sbjct: 296 RYDPPVQ-AVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQ 354 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 V F LG +CLG LAR E + ALL Sbjct: 355 ---------VGFGLGIHYCLGATLARAEAEIGLRALLD 383 >3RWL-A nrPDB Length = 426 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 50/340 (14%), Positives = 108/340 (31%), Gaps = 58/340 (17%) Query: 131 RGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNI 190 + R+ + E I E D + G FD+ ++ ++ Sbjct: 117 PRHDEQRKAVSPIVAPANLA--ALEGTIRERVSKTLDGLPV--GEEFDWVDRVSIEITTQ 172 Query: 191 TNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNA 250 +F F + W + + + Sbjct: 173 MLATLFDFPFEERRKLTR-------------------------WSDVTTAAPGGGVVESW 207 Query: 251 AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 310 L V ++ + + + + + + + E + +V LI+ Sbjct: 208 DQRKTELLECAAYFQVLWNERVNKDPGNDLISML--AHSPATRNMTPEEYLGNVLLLIVG 265 Query: 311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 370 G +TT N + +L + P+ +++ L+ E ++ E++R Sbjct: 266 GNDTTRNSMTGGVLALHKNPDQFAKLKANPALV------------------ETMVPEIIR 307 Query: 371 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG 430 + + + D+ + G +I KG V+ YS + D++ PE F +R Sbjct: 308 WQTPL-AHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR------ 360 Query: 431 YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + + F G C+G LA M++ + + +L RF Sbjct: 361 --PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >2FR7-A nrPDB Length = 412 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 66/375 (17%), Positives = 114/375 (30%), Gaps = 64/375 (17%) Query: 116 MKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGR 175 K + L+ R + + D + G Sbjct: 90 EKPWRPPSLILEADPPAHTRTRAVLSKVLSPATMKR--LRDGFAAAADAKIDELLARGGN 147 Query: 176 PFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI 235 L ++ F + L E E + ++NAF Sbjct: 148 IDAIADLAEAYPLSV----------------FPDAMGLKQEGRENLLPYAGLVFNAFGP- 190 Query: 236 GILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTF 295 P Q +A +++ R P F + Sbjct: 191 ---PNELRQSAIERSAPHQAYVAE-----QCQRPNLAPGGFGACI------HAFSDTGEI 236 Query: 296 SKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK 355 + E V L+ AG +TT N + A+ +A +P+ +++ + L Sbjct: 237 TPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSL------------- 283 Query: 356 CKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWR 415 E +RF + V F T+ D + G +I +G V+ L S + D + W Sbjct: 284 -----ARNAFEEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWD 337 Query: 416 DPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH 475 DP+ + R K V F G C+G+ +AR+E + AL ++ Sbjct: 338 DPDRYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKV---AAI 385 Query: 476 ELVPDLKPRLGMTLQ 490 E+ LK R TL+ Sbjct: 386 EIAGPLKRRFNNTLR 400 >1F4U-A nrPDB Length = 368 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 79/408 (19%), Positives = 137/408 (33%), Gaps = 77/408 (18%) Query: 65 YMRKQSQVY--GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 122 MRK+ VY G I+ + + VLN + L E D + + Sbjct: 7 EMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRY 66 Query: 123 GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQL 182 +L S + R ++ + F ++ E+ I E T+ D+I+ R D + Sbjct: 67 TMLTSDP-PLHDELRSMSADIFSPQKL--QTLETFIRETTRSLLDSIDP---REDDIVKK 120 Query: 183 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 242 + + I I G + E F E +L A GK Sbjct: 121 LAVPLPIIVISKILGLPIEDK--------EKFKEWSDLVA---------------FRLGK 157 Query: 243 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIF 302 ++F + + V V + +S S + Sbjct: 158 PGEIFELGKKYLELIG------YVKDHLNSGTEVVSRVV----------NSNLSDIEKLG 201 Query: 303 SVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTE 362 + L+IAG ETTTN++ +++ + N+ ++++E Sbjct: 202 YIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE-------------------NLYL 241 Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 + E LR+ V + T E + +I +G V + S + DE+ + D E F P Sbjct: 242 KAIEEALRYSPPV-MRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIP 300 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 +R + F G CLG LAR+E + +RF Sbjct: 301 DR---------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFR 339 >2UUQ-A nrPDB Length = 414 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 53/342 (15%), Positives = 103/342 (30%), Gaps = 64/342 (18%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 + R+L F ++ E + + + + G D + + + Sbjct: 101 PPVHTEFRKLVSRGFTPRQV--ETVEPTVRKFVVERLEKLRANGGG--DIVTELFKPLPS 156 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWI--GILPFGKHQQLF 247 + + + + I G Sbjct: 157 MV----------------------VAHYLGVPEEDWTQFDGWTQAIVAANAVDGATTGAL 194 Query: 248 RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307 + + + LIE+ H V A + D + T S ++ + Sbjct: 195 DAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVG----ADGDTAGTLS---ILAFTFTM 247 Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367 + G +T T +L ++ + P+ + + + + I + E Sbjct: 248 VTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI------------------PDAVEE 289 Query: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-RDPEVFHPERFL 426 +LR + V G+ T+ D + +IP G V+ S + DE+ + D R Sbjct: 290 LLRLTSPVQ-GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRC- 347 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 ++ FS G HCLG ARM+ + T LL R Sbjct: 348 --------PRNILTFSHGAHHCLGAAAARMQCRVALTELLAR 381 >5LIV-A nrPDB Length = 450 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 72/389 (18%), Positives = 128/389 (32%), Gaps = 70/389 (17%) Query: 109 RPCLPLFMKMTKMG---GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFF 165 R +M + G G L + G RR N F + E + ++ Sbjct: 104 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRR-VYNMFFLPRAVSQYEERFVRPISEQV 162 Query: 166 NDAIETYKGRP-FDFKQLITNAVSNITNLIIFG---ERFTYEDTDFQHMIELFSENVELA 221 D + G+P D + + +FG E+ D + M+ + A Sbjct: 163 VDRL---AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPA 219 Query: 222 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 281 A A R ++ ++E+ + D L Sbjct: 220 AVAESQ--------------------RAYGETLGLITEVVER--------ESRDTSDTLL 251 Query: 282 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 341 E+ + + E V LI+ G ETT+ ++ I + +P+ +V+++ Sbjct: 252 GEILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS 310 Query: 342 LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVI 401 L+ A + E +R+C G+ D + ++ GT V Sbjct: 311 LL------------------PAAIEEGMRWCP-SSFGVLRMVERDVRLDDQALSAGTVVC 351 Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLF 461 + ++DE + PEV+ +R + F G C+G LARME + Sbjct: 352 LAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVG 403 Query: 462 FTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 ALL RF VP+ +P + Sbjct: 404 LQALLARF---PGLRAVPEERPSFMYGAK 429 >1UE8-A nrPDB Length = 367 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 75/409 (18%), Positives = 134/409 (32%), Gaps = 77/409 (18%) Query: 66 MRKQSQVY--GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGG 123 MRK+S VY G++++L +VLN + L ++ +F + Sbjct: 8 MRKESPVYYDGKVWNLFKYEDCKMVLNDHKRFSSNLTGYNDKLEMLRSGKVFFDIPTRYT 67 Query: 124 LLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLI 183 +L S + R L ++F ++ ++ FD + Sbjct: 68 MLTSDP-PLHDELRNLTADAFNPSNLPVDFVREVTVKLLSELDEE--------FDVIESF 118 Query: 184 TNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKH 243 + + + G + V + + L G+ Sbjct: 119 AIPLPILVISKMLG------------------------INPDVKKVKDWSDLVALRLGRA 154 Query: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303 ++F + +S +K +RK + +S S+ Sbjct: 155 DEIFSIGRKYLELIS-FSKKELDSRKGKEIVDLTGKI----------ANSNLSELEKEGY 203 Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363 L+IAG ETTTN++ AI LY N V++ Sbjct: 204 FILLMIAGNETTTNLIGNAIEDFTLY-NSWDYVRE--------------------KGALK 242 Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 + E LRF V + T E +R I +G V + S + DE+ ++DP+ F P+ Sbjct: 243 AVEEALRFSPPV-MRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPD 301 Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 472 R + + F G CLG LAR+E + ++F + Sbjct: 302 RTPNP---------HLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >6F88-A nrPDB Length = 400 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 72/389 (18%), Positives = 128/389 (32%), Gaps = 70/389 (17%) Query: 109 RPCLPLFMKMTKMG---GLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFF 165 R +M + G G L + G RR N F + E + ++ Sbjct: 54 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRR-VYNMFFLPRAVSQYEERFVRPISEQV 112 Query: 166 NDAIETYKGRP-FDFKQLITNAVSNITNLIIFG---ERFTYEDTDFQHMIELFSENVELA 221 D + G+P D + + +FG E+ D + M+ + A Sbjct: 113 VDRL---AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPA 169 Query: 222 ASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL 281 A A R ++ ++E+ + D L Sbjct: 170 AVAESQ--------------------RAYGETLGLITEVVER--------ESRDTSDTLL 201 Query: 282 DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEID 341 E+ + + E V LI+ G ETT+ ++ I + +P+ +V+++ Sbjct: 202 GEILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS 260 Query: 342 LIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVI 401 L+ A + E +R+C G+ D + ++ GT V Sbjct: 261 LL------------------PAAIEEGMRWCP-SNFGVLRMVERDVRLDDQALSAGTVVC 301 Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLF 461 + ++DE + PEV+ +R + F G C+G LARME + Sbjct: 302 LAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVG 353 Query: 462 FTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 ALL RF VP+ +P + Sbjct: 354 LQALLARF---PGLRAVPEERPSFMYGAK 379 >6HQW-A nrPDB Length = 445 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 59/391 (15%), Positives = 129/391 (32%), Gaps = 43/391 (10%) Query: 113 PLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172 LF + GG+ VD ++LA F + + A Sbjct: 96 ELFSSSWQYGGITIGDPPED-VDPQKLAERQLPMFIAMDRPDHTGQRRTV-----APAFT 149 Query: 173 KGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAF 232 + + + I +++ + + +GERF + D + + A L + Sbjct: 150 PAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFW 209 Query: 233 P-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 291 W G + ++L A + FL + ++ + M + Sbjct: 210 SDWAGDVELTLAREL---ADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMN 266 Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351 S + + ++ LI+ G +TT N + + + +P+ + ++++ LI Sbjct: 267 H--MSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLI-------- 316 Query: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411 + E +R+ + + + D + G I G VI S + DE Sbjct: 317 ----------PNAVQECIRYVTPL-AHMRRTATADTELFGNQIKAGEKVILWYISANRDE 365 Query: 412 KYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL-QRFH 470 + +P+ +R + F G C+G LA +++ + + +R Sbjct: 366 TVFENPDKLMVDR--------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMR 417 Query: 471 LHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 + E+ + R + + E+R Sbjct: 418 VRVAGEVE---RVRANFVHGFRKLEVELEKR 445 >2RFC-A nrPDB Length = 343 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 43/190 (22%), Positives = 74/190 (38%), Gaps = 31/190 (16%) Query: 281 LDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEI 340 + + G + + + + I + LII G ETTTN++ I + P+I Sbjct: 159 IINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIID------ 212 Query: 341 DLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTV 400 + + E LR+ + + +ED+ + I KG V Sbjct: 213 ---------------DALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQV 257 Query: 401 ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFL 460 I L S + DE ++ +P++F R +E + F +G CLG LAR+E + Sbjct: 258 IVYLGSANRDETFFDEPDLFKIGR----------REMHLAFGIGIHMCLGAPLARLEASI 307 Query: 461 FFTALLQRFH 470 +L F Sbjct: 308 ALNDILNHFK 317 >6HQG-A nrPDB Length = 425 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 56/372 (15%), Positives = 117/372 (31%), Gaps = 61/372 (16%) Query: 104 EIFADRPCLPLFMKMTK-MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEET 162 E+F+ P + L + + R+ E I E Sbjct: 80 EVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLAY--LEPIIRERA 137 Query: 163 KFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAA 222 D + G ++ ++ ++ +T +F F +ED Sbjct: 138 GKILDDL--PIGEEINWVDKVSIELTTMTLATLF--DFPWEDRRKL-------------- 179 Query: 223 SASVFLYNAFPWIGIL----PFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD 278 + + + P GIL P + D+ RL + + Sbjct: 180 TFWSDVATSAPESGILGTTDPEEHENLRRQTLFECVDYFMRLWNERVNAPPKP---DLIS 236 Query: 279 AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK 338 + + + + ++ LI+ G +TT N + ++L + P+ ++++ Sbjct: 237 ML------AHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRE 290 Query: 339 EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGT 398 LI A++ E +R+ + + D + G +I +G Sbjct: 291 NPGLI------------------PAMVSETIRWQTPL-AYMRRRAKRDFELGGKTIREGD 331 Query: 399 TVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEM 458 V S + DE+ P + ER + + F G C+G LA +++ Sbjct: 332 KVAMWYVSGNRDEEVIDRPNDYWIER--------PRVRQHLSFGFGVHRCVGNRLAELQL 383 Query: 459 FLFFTALLQRFH 470 + + +L RF Sbjct: 384 KIIWEEILARFP 395 >1Q5D-A nrPDB Length = 419 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 111/346 (32%), Gaps = 53/346 (15%) Query: 125 LNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLIT 184 L R+L SF ++I DA + FD + Sbjct: 95 LFGLPPEDHARVRKLVNPSFTSRAI--DLLRAEIQRTVDQLLDARSGQE--EFDVVRDYA 150 Query: 185 NAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQ 244 + + D F+ + + + V + + Sbjct: 151 EGIPMRAISALLKVPAEC-DEKFRRFGSATARALGVGLVPRVD-------------EETK 196 Query: 245 QLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSV 304 L + L ++++ N L + Q + D S S + L+ V Sbjct: 197 TLVASVTEGLALLHGVLDERRRNPLEN-------DVLTMLLQAEAD-GSRLSTKELVALV 248 Query: 305 GELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAV 364 G +I AGT+TT ++ +A+L + P V+ E L+ Sbjct: 249 GAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPGLMRN------------------A 290 Query: 365 LHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPER 424 L EVLRF NI+ +G +D G SI KG V + S D + P+VF R Sbjct: 291 LDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRR 350 Query: 425 FLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 A + + G C G LAR+E + + +RF Sbjct: 351 ---------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFP 387 >5L1U-A nrPDB Length = 401 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 64/420 (15%), Positives = 128/420 (30%), Gaps = 76/420 (18%) Query: 71 QVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR-- 128 Q G I + G ++ YD V+ L + ++ P + + + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 129 ----YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLIT 184 R L + F + +++I D + P D ++++ Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRL--RLMKTRIEHHVDELLDQL-AASAPPVDLHRVLS 144 Query: 185 NAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQ 244 + + + G + F + + SA+ F Sbjct: 145 FRLPTMVVCDLLGVPLA-DRERFGQWARGTFDQSDNEHSANTF----------------- 186 Query: 245 QLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSV 304 V D++ L+ + V + + + S ++ Sbjct: 187 ------QQVVDYMLELVARKRVEPGDDILSELIA-----------EKDGALSDADIAHLG 229 Query: 305 GELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAV 364 +++ G ETT + L + P + Q+ ++ L A Sbjct: 230 NAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGL------------------APAA 271 Query: 365 LHEVLRFC---NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 + E+LR I D V I G V+ + + ++D++ + D +F Sbjct: 272 VEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFD 331 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFPHELV 478 R + + + F G RHC+G LAR+E+ F L +R L P E + Sbjct: 332 LTR--------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESL 383 >4PWV-A nrPDB Length = 446 Score = 154 bits (390), Expect = 7e-38, Method: Composition-based stats. Identities = 53/345 (15%), Positives = 104/345 (30%), Gaps = 63/345 (18%) Query: 122 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEE-TKFFNDAIETYKGRPFDFK 180 G +L G R + + SF ++ + + + ++ + D Sbjct: 115 GKMLAVTDGAMHRGLRNVLLKSF-----SPQALKPIVDQIRVNTTRLVVDAARRGECD-- 167 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 V+ L + D + +++L N +S W+ Sbjct: 168 --FAADVAEQIPLNTISDLLGVPAADREFLLKL---NKSALSSEDADQSATDAWL----- 217 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 + + S L+ + + ++ +D ++E + Sbjct: 218 --------ARNEILLYFSELVAERRAKPTEDVISVLANSMVD---------GKPLTEEVI 260 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 + + LI+ G ET+ + ++ YP+ ++ Sbjct: 261 VLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRD------------------GKVT 302 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 E+ EVLR+ A + D + G I G V S + DE+ + DP F Sbjct: 303 LESATEEVLRWATPAMHFGRRAVT-DMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAF 361 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465 R + + F G CLG +L R E+ AL Sbjct: 362 DLNRSPNK---------HITFGYGPHFCLGAYLGRAEVHALLDAL 397 >3TKT-A nrPDB Length = 450 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 63/371 (16%), Positives = 114/371 (30%), Gaps = 52/371 (14%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITN-AVS 188 RRL + F + + +I + D + G DF L+ Sbjct: 129 APKHPKLRRLTQDWFMPKNLAR--LDGEIRKIANEAIDRMLGA-GEEGDFMALVAAPYPL 185 Query: 189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR 248 ++ I+ F ++F E + + LP + Q+ Sbjct: 186 HVVMQILGVPPEDEPKMLFLT-QQMFGGQDEDMNKSG---------LKDLPPEQISQIVA 235 Query: 249 -NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307 A + + L + N + +A +D S + Sbjct: 236 GAVAEFERYFAGLAAERRRNPTDDVATVIANAVVD---------GEPMSDRDTAGYYIIT 286 Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367 AG +TT+ A L +A P++ +V+ + +L+ G ++ E Sbjct: 287 ASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPG------------------IVEE 328 Query: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427 +R+ V + + D + G I G ++ N + + D + +P F P R Sbjct: 329 AIRWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR--- 384 Query: 428 SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGM 487 + F G CLG HLAR+EM + LL R + Sbjct: 385 ------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVG 438 Query: 488 TLQPQPYLICA 498 + P A Sbjct: 439 GFKSLPMRWKA 449 >3SN5-A nrPDB Length = 491 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 90/505 (17%), Positives = 160/505 (31%), Gaps = 73/505 (14%) Query: 28 RQLLKQRRPMGFPPGPPGL-PFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGIST 86 ++ +RR G PP GL P++G A+ P ++R + +G +F+ L G Sbjct: 3 KKTSSRRRQTGEPPLENGLIPYLGCALQFGAN---PLEFLRANQRKHGHVFTCKLMGKYV 59 Query: 87 VVLNGYDVVKECLVH-------------QSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW 133 + + L H ++ F R P+ T+ + +G Sbjct: 60 HFITNPLSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 119 Query: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 L + + S + + + + + L Sbjct: 120 -ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGM----------YSFCYRVMFEAGYL 168 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 IFG T DT H++ FP L G +FR A Sbjct: 169 TIFGRDLTRRDTQKAHILNNLDNF--------KQFDKVFP---ALVAGLPIHMFRTAHNA 217 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 + L+ + ++ ++ + + L + ND STF + ++ A Sbjct: 218 REKLAESLRHENLQKRESI------SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQA 271 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDL----------IMGPNGKPSWDDKCKMPYTEA 363 T W++ M P +E+ + G S + +P ++ Sbjct: 272 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 331 Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVV----RGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 ++ E LR + ED + Y+I K + +H D + + DP Sbjct: 332 IIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT 389 Query: 420 FHPERFLDSSGYFAK---------KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 F +R+LD +G K +PF G C G A E+ F +L F Sbjct: 390 FKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 449 Query: 471 LHFPHELV--PDL-KPRLGMTLQPQ 492 L P L + R G+ + P Sbjct: 450 LELIEGQAKCPPLDQSRAGLGILPP 474 >5FYF-A nrPDB Length = 470 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 70/469 (14%), Positives = 159/469 (33%), Gaps = 82/469 (17%) Query: 22 LFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ---------- 71 R+ RRPM +P + N +L ++ + ++ +Q Q Sbjct: 34 FLMSAKRKTFGPRRPMPEFVE-TPIPDV-NTLALE-DIDVSNPFLYRQGQWRAYFKRLRD 90 Query: 72 ----------VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121 +G +S+ + ++ ++F+ P + L + Sbjct: 91 EAPVHYQKNSPFGPFWSVTRF-EDILFVDKSH----------DLFSAEPQIILGDPPEGL 139 Query: 122 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQ 181 + D +R +V K E I T D++ T +PF++ Sbjct: 140 SVEMFIAMDPPKHDVQRSSVQGV-VAPKNLKEMEGLIRSRTGDVLDSLPTD--KPFNWVP 196 Query: 182 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 241 ++ ++ + + + ++E S + A G Sbjct: 197 AVSKELTGRMLATL----LDFPYEERHKLVE-----------WSDRMAGAASATGGEFAD 241 Query: 242 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 301 ++ A + F +K + + P + + L + K+ + I Sbjct: 242 ENAMFDDAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPM---EFI 298 Query: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 361 ++ LI+ G +TT N + ++ M +P +++ + +LI Sbjct: 299 GNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKLKAKPELI------------------ 340 Query: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421 ++ E++R+ + + +D + G +I KG V+ S + DE+ + +P+ F Sbjct: 341 PNMVSEIIRWQTPL-AYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFI 399 Query: 422 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 +R + F G C+G LA +++ + + +L+RF Sbjct: 400 IDR--------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >5HH3-A nrPDB Length = 397 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 67/418 (16%), Positives = 124/418 (29%), Gaps = 76/418 (18%) Query: 82 GGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAV 141 GG + + GYD +++ L + F+ R G L RR+ Sbjct: 50 GGRTAWLATGYDEIRQVLSS--DDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVA 107 Query: 142 NSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFT 201 +F + F+ ++ + DAIE G P DF +V+ G Sbjct: 108 PAFAVRRM--QKFQPQVERVVQDSLDAIEAL-GGPVDFVPRFGWSVATTATCDFLGIPRD 164 Query: 202 YEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLI 261 + + + +E ++ +++++ Sbjct: 165 DQADLARSLHASRTER------------------------SGKRRTAAGNKFMTYMNKMT 200 Query: 262 EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRW 321 + + D + + L ++ AG + L Sbjct: 201 ARTRRDPGD-----------DMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAA 249 Query: 322 AILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFH 381 MA P ++++ D + P W L EV+R+ Sbjct: 250 GAWLMADDPEQFALLREKPDTV------PDW------------LDEVIRYLTTDEKTHPR 291 Query: 382 ATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP-EVFHPERFLDSSGYFAKKEALVP 440 ++D + + I G TV +L + + + + P + F R + + Sbjct: 292 VATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITR---------VRPEHLA 340 Query: 441 FSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICA 498 F G HCLG LA + AL RF E P + L P P+ + A Sbjct: 341 FGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAE------PHREIRLGPPPFDVEA 392 >4DO1-A nrPDB Length = 410 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 43/200 (21%), Positives = 80/200 (40%), Gaps = 31/200 (15%) Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 + + + V L+ AG +TT N + A+ +A +P +++ + L Sbjct: 230 DTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTL-------- 281 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 E +RF + V F T+ + + G I +G V+ L S + D Sbjct: 282 ----------ARNAFEEAVRFESPVQ-TFFRTTTREVELGGAVIGEGEKVLMFLGSANRD 330 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + W DP+++ R K V F G C+G+ +AR+E + +AL ++ Sbjct: 331 PRRWSDPDLYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKV- 380 Query: 471 LHFPHELVPDLKPRLGMTLQ 490 ++ +K R TL+ Sbjct: 381 --AAIDIDGPVKRRFNNTLR 398 >3OO3-A nrPDB Length = 384 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 71/439 (16%), Positives = 134/439 (30%), Gaps = 79/439 (17%) Query: 62 PHVYMRKQSQVYGEIFSLD----LGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMK 117 P + Q G + D + G ++ G+D V+ L + RP + Sbjct: 14 PVPEFEEL-QKAGPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPVDDEADR 72 Query: 118 MTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPF 177 G L RR ++ + +I E + D E+ G P Sbjct: 73 ALLPGILQAYDP-PDHTRLRRTVAPAYSARRMER--LRPRIEEIVEECLDDFESV-GAPV 128 Query: 178 DFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI 237 DF + + G + + MI E+ Sbjct: 129 DFVRHAAWPIPAYIACEFLGVPRD-DQAELSRMIRESRES-------------------- 167 Query: 238 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSK 297 +Q + + ++ RL + + V + + S Sbjct: 168 ---RLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIV-----------REHGAEISD 213 Query: 298 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCK 357 E L +I E L A+L + +P+ ++++ +LI Sbjct: 214 EELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI-------------- 259 Query: 358 MPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 417 ++ EVLR +IV D + G I G + ++ + + Sbjct: 260 ----DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPG----- 310 Query: 418 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHEL 477 + F R +K + F G HC+G LAR+++ + A++ RF Sbjct: 311 DRFDITR---------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVP 361 Query: 478 VPDLKPRLGMTLQPQPYLI 496 DL+ + G +P P+ + Sbjct: 362 EEDLRFKPG---RPAPFAV 377 >6G5O-A nrPDB Length = 399 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 61/435 (14%), Positives = 143/435 (32%), Gaps = 78/435 (17%) Query: 57 ASSELPHVYMR-KQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVH----QSEIFADRPC 111 SELP + + ++S+ YGE ++ +L + V++ + QS R Sbjct: 2 KKSELPDPFEKARESKGYGE---MNDQDDPVTMLLRHKDVRKSAHNYKTFQSGAVPGRIV 58 Query: 112 LPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIET 171 +P + + + +R + F ++ +++ E+ I Sbjct: 59 IPSEVDIRDTRQIPFEVDPPVHGVYRAIVEPWF------KRPLQAEYQEKLTAQISEI-- 110 Query: 172 YKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 231 ++ + + F R + Sbjct: 111 -------VEETLLKGSVEVVTD--FALRLQSRALTLL------------LNTPFSESETW 149 Query: 232 FPWIGILPFGKHQQLF-RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 W + + + L A ++Y ++ I++AS N + +++ + Sbjct: 150 ISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNSEFE-------- 201 Query: 291 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 350 +KE + + G +T N + +I ++A +P +++KE ++ Sbjct: 202 -GRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPEI-------- 252 Query: 351 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 410 T + E++R+ + + + +ED V +++ + + S + D Sbjct: 253 ----------TGRAVEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADSRISLCWASANRD 301 Query: 411 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR-- 468 + +P +R ++ V F +CLG AR + + L Q+ Sbjct: 302 AAVFENPNEIVLDRKVNP---------HVGFGFSHHNCLGATHARQILKILLQTLAQKVA 352 Query: 469 -FHLHFPHELVPDLK 482 F + E + DL Sbjct: 353 SFEILDYKENIEDLD 367 >5H1Z-A nrPDB Length = 407 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 48/348 (13%), Positives = 114/348 (32%), Gaps = 59/348 (16%) Query: 131 RGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNI 190 RR +F + S I T D++E PFD+ ++ ++ Sbjct: 97 PKHTGQRRTVAPAFTPSEMVRMS--DNIRMRTAEVLDSLE--WNTPFDWVDTVSVELTTQ 152 Query: 191 TNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNA 250 I+F F +E+ ++ ++EL + + L + R+ Sbjct: 153 MLAILF--DFPWEERRKLTFWSDWAGDIELVKNEELRL----------------ERLRHM 194 Query: 251 AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 310 + L + + +D + + + ++ LI+ Sbjct: 195 YECGGYFQNLWNAKIGKP---PTPDLISMMI------HSDAMAEMDQMEFLGNLILLIVG 245 Query: 311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 370 G +TT N + + L+P+ + +++ + +I + E++R Sbjct: 246 GNDTTRNTMSAVAYGLDLFPDQRAKLEADPSMI------------------PNTVQEIIR 287 Query: 371 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG 430 + + + + D+ + G I G + S + DE + + + +R Sbjct: 288 WQTPL-AHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR------ 340 Query: 431 YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL-QRFHLHFPHEL 477 + F G C+G LA +++ + + +R ++ E Sbjct: 341 --PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEP 386 >5DE9-A nrPDB Length = 410 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 64/420 (15%), Positives = 121/420 (28%), Gaps = 85/420 (20%) Query: 87 VVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRY 146 +V N +E ++ R L G + RR +F Sbjct: 62 LVTNDPRFGREAVMD-------RQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFTA 114 Query: 147 FGYGQKSFESKILEETKFFNDAIETYK---GRPFDFKQLITNA-VSNITNLIIFGERFTY 202 G ++ E ++ D + G P D + + + + Sbjct: 115 RGV------ERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVIC---------- 158 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKH--QQLFRNAAVVYDFLSRL 260 EL + ++ W ++ H + R + + S L Sbjct: 159 ----------------ELMGVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDL 202 Query: 261 IEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLR 320 I S + + A + + L I G E TN Sbjct: 203 IGLRSDSAGEDVTSLLGAAV----------GRDEITLSEAVGLAVLLQIGG-EAVTNNSG 251 Query: 321 WAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN-IVPLGI 379 + P + +++ E ++ + E+LR+ +G+ Sbjct: 252 QMFHLLLSRPELAERLRSEPEI------------------RPRAIDELLRWIPHRNAVGL 293 Query: 380 FHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALV 439 ED ++G I G V + + + D + + DP+ ER + V Sbjct: 294 SRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP---------HV 344 Query: 440 PFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ-PQPYLICA 498 F G +C G LAR+E L A+L R D+ + G ++ P+ + Sbjct: 345 SFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW 404 >6GII-A nrPDB Length = 479 Score = 144 bits (363), Expect = 8e-35, Method: Composition-based stats. Identities = 63/397 (15%), Positives = 115/397 (28%), Gaps = 72/397 (18%) Query: 88 VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYG------------RGWVD 135 V+ YD +K+ F+ L F + + + RYG ++ Sbjct: 103 VVTRYDTIKQIF-RDPVTFSPSNVLQSFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLE 161 Query: 136 HRRLAVNSFRYFGYGQK--SFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 RR+ + F + + F D D + V L Sbjct: 162 RRRVLMEPFASEHLAEHEPMVRELVRRAVNRFIDTGRA------DLVDQMIWEVPFTVAL 215 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 G + + + V S + + Sbjct: 216 HFLGVD-DDDREKMRRFA--IAHTVNAFGRPS--------------PEEQLAVAETVGQF 258 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 + F ++EK ++ + + + L + +I+A E Sbjct: 259 WQFCGEVLEKMRRTADGP-------GWMRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAHE 311 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 TT A+ + + + ++ + LI A E LR+ Sbjct: 312 TTVFATTNALKTLLEHETVWREICADPSLI------------------PAAAEECLRYNG 353 Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 V G T+ + V G +P G ++ + S + D ++ DPE F R + Sbjct: 354 PV-AGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR--------S 404 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + F G CLG +L RMEM + L +R Sbjct: 405 NASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLP 441 >5HIW-A nrPDB Length = 398 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 77/408 (18%), Positives = 139/408 (34%), Gaps = 75/408 (18%) Query: 87 VVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRY 146 VVL G DVV ++ SE F+ R M G L + G RRL Sbjct: 41 VVLRGADVV--AVLRDSETFSTR-----TYDTGIMKGALVTLGGEAHTRMRRLFNAVLSP 93 Query: 147 FGYGQKSFESKILEETKFFNDAI-ETYKGRPFDFKQLITNAVSNITNLIIFG---ERFTY 202 + E+ + + + + + FD ++ +FG ER Sbjct: 94 RVI-SRYEEATVTPVARRVVERLVRKERAELFD---DFAISMPMGVTSALFGLPEERIAE 149 Query: 203 EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIE 262 D + M + + + + + A + L + E Sbjct: 150 NDALIRKM-----------------IRSVVMPQDPVVVAEGRS---AHAAMEAQLREIAE 189 Query: 263 KASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWA 322 + + L A + E G E V LI+ ETT+ +L Sbjct: 190 REVAHPSDTLLGEIARAIVAEGLGGV---------EACEGVVLTLILGSYETTSWMLANL 240 Query: 323 ILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHA 382 ++ + +P+ Q++++ L+ + E R+C+ GI Sbjct: 241 LVALLAHPDAMNQLRQQPSLL------------------PQAIEESTRWCSSA-AGIVRF 281 Query: 383 TSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS 442 +A + G ++ GT + +L + H+DE+ + PE F R + ++ F Sbjct: 282 VEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR---------RPVGMLNFG 332 Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 G +C+G LARME + + LL+RF P ++P + Sbjct: 333 GGLHYCVGAPLARMEARVGVSLLLERFPALRAD---PTVQPTFSTAPR 377 >6BLD-A nrPDB Length = 419 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 60/358 (16%), Positives = 106/358 (29%), Gaps = 57/358 (15%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R+L +F + E I K D + G DF + + Sbjct: 107 PPRHTKLRKLVSAAFTPRQVRR--IEDSIKINAKGIVDELRMAGGG-VDFVEHCAKELPI 163 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 T + G D + A A+ L + + LF N Sbjct: 164 RTLSDMVG--IPEADRER-------------VAHAADALVSWADPRYLNGREPLAVLFEN 208 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 ++ + L + L V+A +D + ++ L + Sbjct: 209 QMYLHQVAASLAAERRDRPGDDLFSALVNAEVD---------GDRLADADVAAFFVLLAV 259 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG +TT + + + +P+ + + + D +G + E++ Sbjct: 260 AGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVEELV 302 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R+ V + + D + G I G V+ S ++DE + PE R + Sbjct: 303 RWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPH 361 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGM 487 F CLG HLAR ++ F LL + P D G Sbjct: 362 VGFGGGGVH--------FCLGAHLARAQLRAIFGELL----VQLPDIQAGDPVYVPGN 407 >5EX8-A nrPDB Length = 424 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 68/409 (16%), Positives = 124/409 (30%), Gaps = 74/409 (18%) Query: 90 NGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGY 149 G D V++ L + F+ R G L RR+ V +F Sbjct: 85 TGIDEVRQVLGS--DKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPAFS--HR 140 Query: 150 GQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQH 209 + F ++ + + D IE+ G P DF A++ G +D Sbjct: 141 RMQKFRPRVEQIVQDSLDTIESL-GGPVDFVPHFGWAIATPATCDFLG--IPRDDQADLA 197 Query: 210 MIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRK 269 I L S + R A F++ + + + +R+ Sbjct: 198 RILLASRTD-------------------------RSDKRRTAAGNKFMTYMKQHVAQSRR 232 Query: 270 PQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALY 329 D + + + L ++ A + +L M Sbjct: 233 GSG-----DDLFGIVG---RENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQ 284 Query: 330 PNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV 389 P ++++ + + P W L E +R+ ++D + Sbjct: 285 PAQFALLREKPETV------PEW------------LDETMRYLTTDEKTHPRVATQDVRI 326 Query: 390 RGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCL 449 + G TV +L + + Y + F R +K + F G HCL Sbjct: 327 GNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR---------EKAEHLAFGHGIHHCL 376 Query: 450 GEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICA 498 G +A + + AL RF P + D + +TL P P+ + A Sbjct: 377 GRAMAELMFKVSIPALAHRF----PTLRLADPQRE--ITLGPPPFDVEA 419 >6DCD-A nrPDB Length = 424 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 105/364 (28%), Gaps = 67/364 (18%) Query: 107 ADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFN 166 A R P++ M M R + Q E + Sbjct: 87 AHREQFPMYEHMVTMD-------PPEHSRARSILSRLLTPSRLKQN--EEFMWRLADRQL 137 Query: 167 DAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASV 226 D +F + + + G + DF+ Sbjct: 138 DEF--LGAGECEFISEYAKPFATLVIADLLGVPED-DRKDFR------------------ 176 Query: 227 FLYNAFPWIGILPFGKHQQLFRN-AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMD 285 + +G + H+ + N + D S IE + L + Sbjct: 177 -VVLGADRMGRVGALDHESVGVNPLQWLDDKFSAYIEDRRRQPRND--------VLTALA 227 Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 ST +++ S L AG ETT +L A+ + P+IQ ++++ LI Sbjct: 228 TATYPDGSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRENRSLI-- 285 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLY 405 + E LR + V + V G I GT V+ Sbjct: 286 ----------------PNFIEESLRMDSPVKSDS-RLARKRTTVGGLDIAAGTVVMVLPG 328 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465 + + D + + DP F +R + F+ G C G LAR+E + + Sbjct: 329 AANRDPRRFEDPHEFRLDR--------PNVREHMAFARGVHSCPGGPLARVEGRVSLERI 380 Query: 466 LQRF 469 L R Sbjct: 381 LDRM 384 >5HDI-A nrPDB Length = 404 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 62/402 (15%), Positives = 126/402 (31%), Gaps = 73/402 (18%) Query: 80 DLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPL------------FMKMTKMGGLLNS 127 + + G+D V E + + E F+ + + +L + Sbjct: 34 RIANSDFYAVCGWDAVNEA-IGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLAT 92 Query: 128 RYGRGWVDHRRLAVNSFRYFGYGQKSFES-KILEETKFFNDAIETYKGRPFDFKQLITNA 186 HR+L + + E + + + D ++ D A Sbjct: 93 ADDPAHAVHRKLVLR--HLAAKRIRVMEQFTVQAADRLWVDGMQ-------DGCIEWMGA 143 Query: 187 VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL 246 ++N +++ E D D +++ A+ L G++ + Sbjct: 144 MANRLPMMVVAELIGLPDPDIAQLVK--------WGYAATQLLE-----GLVENDQLVAA 190 Query: 247 FRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGE 306 + ++ ++A+ + + L A S + Sbjct: 191 GVALMELSGYIFEQFDRAAADPRDNLLGELATAC----------ASGELDTLTAQVMMVT 240 Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366 L AG E+T +L A+ +A P+IQ QV+ +L+ A + Sbjct: 241 LFAAGGESTAALLGSAVWILATRPDIQQQVRANPELL------------------GAFIE 282 Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426 E LR+ G + + G +P + ++ + + D + P F +R Sbjct: 283 ETLRYEPPFR-GHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR-- 339 Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 468 A + + F G C+G LAR+E + LL R Sbjct: 340 ------AGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >6HQD-A nrPDB Length = 420 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 62/417 (14%), Positives = 125/417 (29%), Gaps = 69/417 (16%) Query: 67 RKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLN 126 ++ YG +S+ + + V H + F L GG+ Sbjct: 49 YCKASEYGPYWSITKFSDIVAIDTNHKVFSSD--HTNGSF----VLDDTTLNAVDGGIYL 102 Query: 127 SRY----GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQL 182 + HR + + FE+ I E TK + G F++ Sbjct: 103 PNFLGMDPPKHDVHRMVVSPIVAPQNLLR--FEATIRERTKRVLSEL--PIGEEFNWVDR 158 Query: 183 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 242 ++ ++ + + F + + P G Sbjct: 159 VSIELTTMMLATLLDFPFDDRRKLTR----------------WSDIITTRP--GYGLVDS 200 Query: 243 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIF 302 +Q + RL + + + + + + Sbjct: 201 WEQRESELMECLAYFQRLYAERQAMPPKP-------DLISMLAHSPEMQD--LTPTDFLG 251 Query: 303 SVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTE 362 ++ LI+ G +TT + + + + LYP +V+ L+ Sbjct: 252 TLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVRNNRALLAS----------------- 294 Query: 363 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 422 V+ EV+R+ + + ED RG I KG V+ S + D++ P F Sbjct: 295 -VIPEVVRWQTPI-AHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIA 352 Query: 423 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF-HLHFPHELV 478 +R + + F G CLG LA +++ + + + +R+ + E V Sbjct: 353 DR--------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPV 401 >2NZA-A nrPDB Length = 413 Score = 132 bits (333), Expect = 3e-31, Method: Composition-based stats. Identities = 56/365 (15%), Positives = 105/365 (28%), Gaps = 69/365 (18%) Query: 119 TKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFD 178 + G L + RR +F + + E D I +G P D Sbjct: 91 PRPGSLAFADQ-PDHNRLRRAVAGAFTVGATKR--LRPRAQEILDGLVDGILA-EGPPAD 146 Query: 179 FKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGIL 238 + + + G D + H S + + + Sbjct: 147 LVERVLEPFPIAVVSEVMG--VPAADRERVH-------------SWTRQIIST------- 184 Query: 239 PFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKE 298 G + R +Y +++ + + + + A + Sbjct: 185 -SGGAEAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAV----------GRGEVGET 233 Query: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKM 358 + G L I G E T+ + + + + ++++ Sbjct: 234 EAVGLAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMRERPG----------------- 275 Query: 359 PYTEAVLHEVLRFCN-IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDP 417 L E+LR+ + +G+ ED V G I G V + + + D + DP Sbjct: 276 -ARGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDP 334 Query: 418 EVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FHLHFP 474 + +R + + + G C G LARM+ L LL+R L P Sbjct: 335 DRIDLDRDPNP---------HLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVP 385 Query: 475 HELVP 479 E V Sbjct: 386 AEQVA 390 >3WEC-A nrPDB Length = 419 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 59/372 (15%), Positives = 109/372 (29%), Gaps = 66/372 (17%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 R L ++F S + +L +E + + V + Sbjct: 105 PPEHTRLRGLVSDAFTRSTTT--SMDDIVLSAASSAVRHLEHCTDAVSEVAEPFPVEVLS 162 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 I + F L + +++ + +P + Sbjct: 163 SILGIP-----DKDRGRFSEWSNLVAGVLDINFA--------------IPKEVADRRSAA 203 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 D+ L P+ V + S + + + + + Sbjct: 204 IEESIDYFRTLATS------GNAPEGLVRRL-----SEVSHGGDQLSVDEIAATCLLITV 252 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 AG ETT+N + ++ + + + QV+ + E + EVL Sbjct: 253 AGQETTSNTIGNMLITFSRHADQFEQVRANPQ------------------FIENAVAEVL 294 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 RF ED V G +I KG V+ L S + + + F R Sbjct: 295 RFEPPA-HEAGRIALEDCEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR----- 346 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 489 + + + G HCLG LA + F L QR+ E+ + + GM L Sbjct: 347 ----PDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYR---SIEVAEPINYKPGMGL 399 Query: 490 Q-PQPYLICAER 500 + P+ + R Sbjct: 400 RGPETLSVAVSR 411 >2WIY-A nrPDB Length = 394 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 53/341 (15%), Positives = 108/341 (31%), Gaps = 57/341 (16%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 RR F + E D +E G+ + ++ + ++ Sbjct: 84 PPHHTVLRRQTNKWFTPKLV--DGWVRTTRELVGDLLDGVEA--GQVIEARRDLAVVPTH 139 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 +T + D + M E ++ A A + Sbjct: 140 VTMARVLQLPEDDADAVMEAMFEAM--LMQSAEPADGDVDR------------------- 178 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 AAV + +LS + + +++ D+ LD G+ ++ I ++ Sbjct: 179 AAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGE------ITESEAIATILVFYA 232 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 G ++ I A P + + + A+++E++ Sbjct: 233 VGHMAIGYLIASGIELFARRPEVFTAFRNDES------------------ARAAIINEMV 274 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R L +ED + G I G+ + + + + D + + DP+VF R +S Sbjct: 275 RMDPP-QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTRPPAAS 333 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470 + F LG C G+ ++R E F L +R+ Sbjct: 334 -------RNLSFGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >6FYJ-A nrPDB Length = 421 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 66/426 (15%), Positives = 134/426 (31%), Gaps = 68/426 (15%) Query: 75 EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP--LFMKMTKMGGLLNSRYGRG 132 +IF L G + + G + E E F + P + + G+ G+ Sbjct: 39 DIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKDAAPNRVVQTLFGKNGVQALD-GQT 95 Query: 133 WVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITN 192 + + ++ + ++ + D E + + Sbjct: 96 HKHRKEMFMSIMSPDELEK--LTDITKKQWEIAVDKWEQMD--KVILYEEAKEIMCRTAC 151 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV 252 ++ + + + + E AA+ W+G + RN Sbjct: 152 QW---AGVPVQENEVKRLTKNLGAMFESAAA-----VGLKHWLG--------RHARNYEE 195 Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI---I 309 ++ + LI++ K P++ L + ++ + E V ++ + Sbjct: 196 IW--IEELIDRVRDG-KVNPPENTT---LHKFSWYRDLEGNLLDTETAAVEVINILRPIV 249 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 A + + L + YP + +++ Y++ + EV Sbjct: 250 A----IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVR 288 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 RF P + +D +GY +GT + +LY + D + W++P+VF P+RF Sbjct: 289 RFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWE 347 Query: 430 GYFAKKEALVPFSLGR----RHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485 G + +P G C GE + M + L R VPD Sbjct: 348 GS---PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE-----VPDQDLSF 399 Query: 486 GMTLQP 491 M P Sbjct: 400 SMASMP 405 >3OFT-A nrPDB Length = 396 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 68/393 (17%), Positives = 114/393 (29%), Gaps = 67/393 (17%) Query: 74 GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW 133 G ++S GG DVV+E L +E + + M + + G Sbjct: 38 GLVWSTANGGHWIAARG--DVVRE-LWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEH 94 Query: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 R + + E K+ + +++ DF I L Sbjct: 95 KAFRTPVMKGLASRFVV--ALEPKVQAVARKLMESLRPR--GSCDFVSDFA----EILPL 146 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 IF D + +L + S +QL + A Sbjct: 147 NIFLTLIDVPLEDRPRLRQLGVQLTRPDGS-----------------MTVEQLKQAAD-- 187 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 D+L IEK L + + ++ + L+ G + Sbjct: 188 -DYLWPFIEKRMAQPGDDLFSRILSEPVG---------GRPWTVDEARRMCRNLLFGGLD 237 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 T ++ L +A +P Q +++ DLI A E++R Sbjct: 238 TVAAMIGMVALHLARHPEDQRLLRERPDLI------------------PAAADELMRRYP 279 Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 V + D G +I KG V + D + PE +R L Sbjct: 280 TV--AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL------- 330 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 466 +G C+G LARME+ +F L Sbjct: 331 APIRHTTMGVGAHRCVGAGLARMEVIVFLREWL 363 >1WIY-A nrPDB Length = 389 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 71/412 (17%), Positives = 133/412 (32%), Gaps = 73/412 (17%) Query: 85 STVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSF 144 ++ + V+ L+ + + G L + +G+ W + R+ + F Sbjct: 42 PLALIFDPEGVEGALLAEG---TTKATFQYRALSRLTGRGLLTDWGKSWKEARKALKDPF 98 Query: 145 RYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYED 204 + + + EE F ++G D + + +FG+ + Sbjct: 99 LPKSV--RGYREAMEEEAWAF---FGEWRGEERDLDHEMLALSLRLLGRALFGKPLSPSL 153 Query: 205 TDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKA 264 + H ++ + S +L + ++ +Y LI Sbjct: 154 AE--HALKALDRIMAQTRSPL----------ALLDLAAEARFRKDRGALYREAEALI--- 198 Query: 265 SVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAIL 324 + P S +E + L++AG ET + L W+ L Sbjct: 199 -----------------------VHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFL 235 Query: 325 FMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATS 384 ++ P+ Q +V A E LR + + Sbjct: 236 LLSHRPDWQKRV------------------AESEEAALAAFQEALRLYPPAWI-LTRRLE 276 Query: 385 EDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLG 444 ++ +P+GTT++ + Y Y+ + E F PERFL G PF LG Sbjct: 277 RPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERFLAERGT--PSGRYFPFGLG 332 Query: 445 RRHCLGEHLARMEMFLFFTALLQRFHLHFPHEL----VPDLKPRLGMTLQPQ 492 +R CLG A +E + A +RF L L+P G+ +P+ Sbjct: 333 QRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPR 384 >5OMS-A nrPDB Length = 409 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 44/347 (12%), Positives = 105/347 (30%), Gaps = 47/347 (13%) Query: 121 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180 + G D R + + + + + + + + + E D Sbjct: 78 GHPAIIGVNGDIHADLRSMVEPALQPAEV-DRWIDDLVRPIARRYLERFEN------DGH 130 Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240 + ++ G+ ++ D + E F++ +A+V F Sbjct: 131 AELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFTNAAVDENGEFANPEGFAE 190 Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300 G + A + + LI+K + H++ + P T +E + Sbjct: 191 GD-----QAKAEIRAVVDPLIDKWIEHPDDSAISHWLHDGM--------PPGQTRDREYI 237 Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360 ++ ++ + + + ++ + P +V + LI Sbjct: 238 YPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDPTLI----------------- 280 Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420 + E LR+ + + +++ + G +P GT V+ + S + D + P + Sbjct: 281 -PRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQY 339 Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467 R + F G C G + A M + L + Sbjct: 340 DLHR---------PPLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >5YHJ-A nrPDB Length = 413 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 77/450 (17%), Positives = 152/450 (33%), Gaps = 95/450 (21%) Query: 63 HVYMRKQSQVY-GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP--LFMKMT 119 ++++ + + + IF L G + L G + E ++ F + P L + Sbjct: 22 YLFVANRRKSFQSNIFESRLLGERVICLGGEEAA-EVFYDANK-FTRQDAAPKRLLKTLF 79 Query: 120 KMGGLLNSRYGRG------------WVDHRRLAVNSFRYFGYGQKSFESKIL-EETKF-F 165 GG+ + RL ++R + ++ E +L + + Sbjct: 80 GEGGVQTLDGSEHTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEIVLYDIAQEVL 139 Query: 166 NDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASAS 225 A+ + G P +++ G+R + M LF L Sbjct: 140 MKAVCEWSGVPLAKEEV--------------GKR-------TEEMRLLFESGTSLG---- 174 Query: 226 VFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMD 285 P + R++A V+ + +++++ NR LP Y E Sbjct: 175 -------------PTYLQGRKARSSAEVW--IRQMVKEVRSNR--LLPNEHTALY--EFS 215 Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345 +++ +E + V ++ + VL + +L + +P+++ QV Sbjct: 216 WHRDESGELLPEEVVAVEVLNILRPTVAISVYVL-FTVLALHQFPDVKEQV--------- 265 Query: 346 PNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLY 405 ++ ++ TE + EV RF P+ + D GY+ P+GT + +LY Sbjct: 266 --------ERGEVSKTE-FVQEVRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLY 315 Query: 406 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR----RHCLGEHLARMEMFLF 461 + D W +P+ F P RF D +P G C GEH+ Sbjct: 316 GTNHDVSIWTEPDRFDPSRFKDWKES---PFNFIPQGGGDVDFGHRCAGEHVTIA----I 368 Query: 462 FTALLQRFHLHFPHELVPDLKPRLGMTLQP 491 +++ F + VP P Sbjct: 369 LAQVIELFTKEY-AYTVPPQDLSYSFVDMP 397 >4FB2-A nrPDB Length = 398 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 67/441 (15%), Positives = 133/441 (30%), Gaps = 79/441 (17%) Query: 59 SELPHVYMRKQSQVYGEIFSLDLGGISTV----VLNGYDVVKECLVHQSEIFADRPCLPL 114 PH + + +G V+ GY + + ++ ++ F+++ Sbjct: 18 DGTPHAFFEALRDE---AETTPIGWSEAYGGHWVVAGYKEI-QAVIQNTKAFSNKGVTFP 73 Query: 115 FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDA-IETYK 173 + + ++ + +R+L F F ++ + T DA IE + Sbjct: 74 RYETGEFELMMAGQDDPVHKKYRQLVAKPFSP--EATDLFTEQLRQSTNDLIDARIELGE 131 Query: 174 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 233 G D + N + I+ G Y + Sbjct: 132 G---DAATWLANEIPARLTAILLG-----------------------LPPEDGDTYRRWV 165 Query: 234 WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS 293 W ++ A + LI + N + + + +D Sbjct: 166 WAITHVENP-EEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKID---------GE 215 Query: 294 TFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD 353 + S+++LI L++ G + T L +A ++ ++ +LI Sbjct: 216 SLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRLIAHPELI---------- 265 Query: 354 DKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKY 413 + E+LRF +G +++ V ++ G T + D Sbjct: 266 --------PNAVDELLRFYGPAMVG--RLVTQEVTVGDITMKPGQTAMLWFPIASRDRSA 315 Query: 414 WRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQR---FH 470 + P+ ER + + G CLG HL R+E + T L+R F Sbjct: 316 FDSPDNIVIERTPNR---------HLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFS 366 Query: 471 LHFPHELVPDLKPRLGMTLQP 491 L E + GM P Sbjct: 367 LDPNKECEWLMGQVAGMLHVP 387 >2IJ7-A nrPDB Length = 396 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 54/365 (14%), Positives = 118/365 (32%), Gaps = 64/365 (17%) Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195 R+ + + G E + + D + +G P D + + ++ + + Sbjct: 94 LRKAVMKAITPKAPG---LEQFLRDTANSLLDNL-ITEGAPADLRNDFADPLATALHCKV 149 Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255 G F+ + F + + +A + N + Sbjct: 150 LGIPQEDGPKLFRSLSIAFMSSADPIPAAKI----------------------NWDRDIE 187 Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPS-STFSKENLIFSVGELIIAGTET 314 +++ ++E + + E+ + + DP+ S S E AG + Sbjct: 188 YMAGILEN----------PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVIS 237 Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374 T + L A++ + P ++ + ++ +LI A + E+LR Sbjct: 238 TGSFLTTALISLIQRPQLRNLLHEKPELI------------------PAGVEELLRINLS 279 Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434 G+ + D V + KG V+ L +FD +++ +P +R Sbjct: 280 FADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR--------PN 331 Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ-PQP 493 + + F G+ C G L R + ALL++ + L R + P+ Sbjct: 332 PTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPER 391 Query: 494 YLICA 498 + Sbjct: 392 LPVLW 396 >6G71-A nrPDB Length = 405 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 43/232 (18%), Positives = 75/232 (32%), Gaps = 36/232 (15%) Query: 240 FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKEN 299 + ++ A D + +E+ + + L E+ Sbjct: 173 YPDDPDVWAKAKQSSDEIDAALEEMIQWHSGRPGDSLLSYLL-------RSADYQMPLES 225 Query: 300 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 359 + ++ I G +VL + L + V ++ L Sbjct: 226 IRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDPKL----------------- 268 Query: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 AV E +R+ + + + T D + GY IP+G + + S + D W DP+ Sbjct: 269 -WGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDR 326 Query: 420 FHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMF-LFFTALLQRFH 470 F ER EA + F G CLG AR ++ + AL R Sbjct: 327 FDIER---------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLK 369 >5KYO-A nrPDB Length = 430 Score = 118 bits (295), Expect = 7e-27, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 75/248 (30%), Gaps = 39/248 (15%) Query: 251 AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 310 ++L +IE + + ++ + + ++++ Sbjct: 220 KQFREYLRPVIEARRIKPGEDMISRMINGEVG---------GRPLTDIEAENICIQVLVG 270 Query: 311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 370 G +T N+L + +A ++ + + LI + L E R Sbjct: 271 GLDTVVNMLGFTFSHLAKDHALRRAIAADPSLI------------------DDALLEFFR 312 Query: 371 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG 430 +V D G + G V+ V D+ DP F R Sbjct: 313 RFPVVSSA--REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR------ 364 Query: 431 YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQ 490 K F G C G HLARMEM + R F E L+ G+ Sbjct: 365 ---KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIP-EFRIEDDAPLRYSNGIVGS 420 Query: 491 PQPYLICA 498 +P+++ Sbjct: 421 VKPFVLEW 428 >3BUJ-A nrPDB Length = 397 Score = 117 bits (294), Expect = 8e-27, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 83/214 (38%), Gaps = 35/214 (16%) Query: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303 + + R A + +F +E+A R+ + + + LD D+G S+ ++ + Sbjct: 174 EDMRRGHAAIAEFADY-VERALARRRREGGEDLLALMLDAHDRG------LMSRNEIVST 226 Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363 V I G ET + + A+L + +P+ +++ DL+ Sbjct: 227 VVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPDLLA------------------Q 268 Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423 + E LR+ V D +RG + + V+ + + D + + P+ F E Sbjct: 269 AVEECLRYDPSVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIE 327 Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARME 457 R + F G R+CLG +LAR + Sbjct: 328 R---------DPVPSMSFGAGMRYCLGSYLARTQ 352 >5D3U-A nrPDB Length = 427 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 55/368 (14%), Positives = 103/368 (27%), Gaps = 59/368 (16%) Query: 106 FADRPCLP--LFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETK 163 F +P P +F + TK + RR F + ++ + + Sbjct: 89 FPGQPLPPDNIFHRWTKNVVMYTDP--PLHDALRRSVRAGFTRA--AHQHYDQVLQKVAH 144 Query: 164 FFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAAS 223 +I D + + + + FG E++ Sbjct: 145 DLVASIPAG-ATEIDAVPALAAELPVRSAVHAFGVP---------------EEDLGFLIP 188 Query: 224 ASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 + F P + + ++ + S L++ P + Sbjct: 189 RVNTIMTYFSGPKDQPV-TQEIILEKLTDLHTYASELLQGMRGKVLPDT--------VIA 239 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTE-TTTNVLRWAILFMALYPNIQGQVQKEIDL 342 D + + E + + + IA TT L L A P + + Sbjct: 240 RLAAAQDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQAC 299 Query: 343 IMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVIT 402 + + +EVLR+ ++D + G I G T+ Sbjct: 300 V------------------DNTANEVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQTLAL 340 Query: 403 NLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFF 462 L S + D + P F +R + F G CL L +++ F+ Sbjct: 341 FLGSANRDANMFERPNDFDLDR--------PNSARHLSFGQGVHACLAAQLISLQLKWFY 392 Query: 463 TALLQRFH 470 ALL RF Sbjct: 393 VALLNRFP 400 >2QBO-A nrPDB Length = 421 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 56/367 (15%), Positives = 110/367 (29%), Gaps = 66/367 (17%) Query: 135 DHRRLAVNSFRYFGY-GQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193 + R+ + + G E++I E +++ Sbjct: 108 EQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQG-------------------Q 148 Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253 F E Y + + L + E +L + + + Sbjct: 149 CNFTE--DYAEPFPIRIFMLLAGLPEEDIPHLKYLTD-----QMTRPDGSMTFAEAKEAL 201 Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313 YD+L +IE+ + + + + G L++ G + Sbjct: 202 YDYLIPIIEQRRQKPGTDAISIVANGQV---------NGRPITSDEAKRMCGLLLVVGLD 252 Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373 T N L +++ F+A P + ++ + + I A E+LR + Sbjct: 253 TVVNFLSFSMEFLAKSPEHRQELIERPERI------------------PAACEELLRRFS 294 Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 +V G + D G + KG ++ DE+ P R Sbjct: 295 LVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSR--------- 343 Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQP 493 +K + F G CLG+HLAR E+ + L R F ++ + G+ Q Sbjct: 344 QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIP-DFSIAPGAQIQHKSGIVSGVQA 402 Query: 494 YLICAER 500 + + Sbjct: 403 LPLVWDP 409 >2ZQJ-A nrPDB Length = 417 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 66/439 (15%), Positives = 140/439 (31%), Gaps = 65/439 (14%) Query: 49 IGNIYSLAASSELPHVYMRKQSQVY-GEIFSLDLGGISTVVLNGYDVVKECL----VHQS 103 + N +L +++++ +++ Y ++F L G + + + G + K + Sbjct: 11 LDNSLTLLKEG---YLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQ 67 Query: 104 EIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETK 163 R LF G ++ HR++ S QK + EE K Sbjct: 68 NALPKRVQKSLFGVNAIQGMDGSAHI------HRKMLFLSL-MTPPHQKRLAELMTEEWK 120 Query: 164 FFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAAS 223 E + + + + ++T+ + + F Sbjct: 121 AAVTRWEKAD--EVVLFEEAKEILCRVAC---YWAGVPLKETEVKERADDF--------- 166 Query: 224 ASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 + + +AF +G +H + R +++ +IE A + Sbjct: 167 --IDMVDAFGAVG----PRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFH 220 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 343 + + S + LI + ++ + L ++ L + +P + ++ Sbjct: 221 TQEDGSQLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRS----- 270 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403 E + EV R+ P + +D V KGT+V+ + Sbjct: 271 ------------GNSREREMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLD 317 Query: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR----RHCLGEHLARMEMF 459 LY + D + W P+ F PERF + ++P G C GE + M Sbjct: 318 LYGTNHDPRLWDHPDEFRPERFAEREENL---FDMIPQGGGHAEKGHRCPGEGITIEVMK 374 Query: 460 LFFTALLQRFHLHFPHELV 478 L+ + P + + Sbjct: 375 ASLDFLVHQIEYDVPEQSL 393 >5M0P-A nrPDB Length = 428 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 74/422 (17%), Positives = 134/422 (31%), Gaps = 59/422 (13%) Query: 76 IFSLD-LGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK--MGGLLNSRYGRG 132 +F LGG VV+ G + + + R + + G +++ G+ Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMF---YNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKK 97 Query: 133 WVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITN 192 VD + L ++ + + + + + +I Sbjct: 98 HVDRKALFMSLMTEGNLNY----------VRELTRTLWHANTQRMESMDEVNIYRESIVL 147 Query: 193 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAV 252 L G R+ ++ E++E A+ + ++F +G F ++ Sbjct: 148 LTKVGTRW--------AGVQAPPEDIERIATDMDIMIDSFRALGGA-FKGYKASKEARRR 198 Query: 253 VYDFLSR-LIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311 V D+L +IE N P + + D N S +L+ + LI Sbjct: 199 VEDWLEEQIIETRKGNIHPPEGTALYE-FAHWEDYLGNPMDSRTCAIDLMNTFRPLIA-- 255 Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371 + + + M P + +++ E D Y EV R+ Sbjct: 256 ---INRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRY 294 Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431 VP + D +G +IP G + ++Y DE W DP F PERF G Sbjct: 295 YPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGS 353 Query: 432 FAKKEALVPFSLGR----RHCLGEHLARMEMFLFFTALLQRFHLHFPHELV-PDLKPRLG 486 L+P G C GE + + M ++ P + + DL G Sbjct: 354 ---PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSIPG 410 Query: 487 MT 488 Sbjct: 411 YV 412 >3B98-A nrPDB Length = 475 Score = 110 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 78/495 (15%), Positives = 163/495 (32%), Gaps = 61/495 (12%) Query: 32 KQRRPMGFPPGPPG-LPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLN 90 ++ R PP G +P++G+ + ++ + + +G+IF++ G+ VL Sbjct: 12 RRTRRRNEPPLDKGMIPWLGHALEFGKDAAK---FLTRMKEKHGDIFTVRAAGLYITVLL 68 Query: 91 GYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYG 150 + L + + L ++ M ++ S Sbjct: 69 DSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNS 128 Query: 151 QKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM 210 ++ ++ ++ E K F+ + L +FG + Sbjct: 129 MQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGY---LTVFGAE-NNNSAALTQI 184 Query: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 E F +L + N ++ + A+ + L + + + ++RKP Sbjct: 185 YEEFRRFDKLLPKLARTTVN-------------KEEKQIASAAREKLWKWLTPSGLDRKP 231 Query: 271 QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII----AGTETTTNVLRWAILFM 326 Q ++ +Y+ ++ D + + +L + AG W + ++ Sbjct: 232 -REQSWLGSYVKQLQDEGIDA-----EMQRRAMLLQLWVTQGNAGP-----AAFWVMGYL 280 Query: 327 ALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSED 386 +P V++EI G + + P ++VL E LR I ++D Sbjct: 281 LTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLTAAA--LITRDVTQD 335 Query: 387 AVV-----RGYSIPKGTTVITNL-YSVHFDEKYWRDPEVFHPERFLDSSGYFAK------ 434 + + Y + +G + S D + + PE+F +RFL++ K Sbjct: 336 KKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNG 395 Query: 435 ---KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE--LVPDLKPR---LG 486 K VP+ C G H A + +L RF + + VP + P G Sbjct: 396 ARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFG 455 Query: 487 MTLQPQPYLICAERR 501 + I R Sbjct: 456 ILQPAGDLEIRYRIR 470 >3NV6-A nrPDB Length = 452 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 48/369 (13%), Positives = 104/369 (28%), Gaps = 61/369 (16%) Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189 +R+ + E K+ E D+ DF Sbjct: 141 PPEHTPYRKALDKGLNLAKIRK--VEDKVREVASSLIDSFAAR--GECDFAAEYAELFP- 195 Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249 F + +L E++ + + + + G P L Sbjct: 196 --------------VHVFMALADLPLEDIPVLSEYARQMTRP---EGNTPEEMATDLEAG 238 Query: 250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 309 Y ++ +I L V++ + + + + L++ Sbjct: 239 NNGFYAYVDPIIRARVGGDGDDLITLMVNSEI---------NGERIAHDKAQGLISLLLL 289 Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369 G +T N L + ++ +A +P + +++ + +M E+ Sbjct: 290 GGLDTVVNFLSFFMIHLARHPELVAELRSDPLKLMRG------------------AEEMF 331 Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 R +V ++D +G + +G ++ D+ +P R Sbjct: 332 RRFPVVSEA--RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR----- 384 Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 489 + + F G C G HLARME+ + L+R F + G+ Sbjct: 385 ----RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIP-EFSFKEGETPIYHSGIVA 439 Query: 490 QPQPYLICA 498 + + Sbjct: 440 AVENVPLVW 448 >4C9K-A nrPDB Length = 421 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 51/401 (12%), Positives = 112/401 (27%), Gaps = 67/401 (16%) Query: 104 EIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETK 163 E F+ R + +R+ + E +I Sbjct: 81 ERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIRK--LEDQIRTIAV 138 Query: 164 FFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAAS 223 + +F +F R F + L E+ Sbjct: 139 EIIEGFADR--GHCEFGSEF---------STVFPVRV------FLALAGLPVEDATKLGL 181 Query: 224 ASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 283 + + G P + + L +++++ +I L ++ +D Sbjct: 182 LANEMTRP---SGNTPEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDLITRILNVEID- 237 Query: 284 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 343 + + V L++ G +T N L + +++++ +P ++++E Sbjct: 238 --------GKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRREP--- 286 Query: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403 + + E+ R +V D G + +G ++ Sbjct: 287 ---------------LKLQRGVEELFRRFAVVSDA--RYVVSDMEFHGTMLKEGDLILLP 329 Query: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFT 463 D+++ DP R + F+ G C G HLAR+E+ + Sbjct: 330 TALHGLDDRHHDDPMTVDLSR---------RDVTHSTFAQGPHRCAGMHLARLEVTVMLQ 380 Query: 464 ALLQR---FHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501 L R F L + G+ + + E + Sbjct: 381 EWLARIPEFRLKDRAVPI----YHSGIVAAVENIPLEWEPQ 417 >2IAG-A nrPDB Length = 482 Score = 99.4 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 85/492 (17%), Positives = 157/492 (31%), Gaps = 56/492 (11%) Query: 32 KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNG 91 + RRP P +P++G + ++ + + +G+IF++ +GG VL Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAAS---FLTRMKEKHGDIFTILVGGRYVTVLLD 57 Query: 92 YDVVKECL--VHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGY 149 + F + L ++ + S L + Sbjct: 58 PHSYDAVVWEPRTRLDF-HAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTE 116 Query: 150 GQ-KSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQ 208 + + +L + F + L+ + + + D Sbjct: 117 AMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRV 176 Query: 209 HMIELFSENVELAASASVFLYNAFPWI--GILPFGKHQQLFRNAAVVYDFLSRLIEKASV 266 H ++F L P + G L G + + ++ LS Sbjct: 177 HSADVFHTF--------RQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRA 228 Query: 267 NRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFM 326 +R L + + +L+EM + + + L + G + A W +LF+ Sbjct: 229 HRSKWLESYLL--HLEEMGVSEEMQARALVLQ-LWATQGNMGPAAF--------WLLLFL 277 Query: 327 ALYPNIQGQVQKEIDLIMGPNGKP-------SWDDKCKMPYTEAVLHEVLRFCNIVPLGI 379 P V+ E++ I+ +P P ++VL E LR I Sbjct: 278 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP--FI 335 Query: 380 FHATSEDAVV-----RGYSIPKGTTVITNL-YSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 D + R +++ +G ++ S D + + DPEVF RFL+ G Sbjct: 336 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 395 Query: 434 K---------KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF--PHELVPDLK 482 K K +P+ G HCLG A + F +L L +P+ Sbjct: 396 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 455 Query: 483 P-RLGMTL-QPQ 492 R G L QP+ Sbjct: 456 LSRYGFGLMQPE 467 >3AWQ-A nrPDB Length = 415 Score = 96.0 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 65/441 (14%), Positives = 122/441 (27%), Gaps = 63/441 (14%) Query: 62 PHVYMRKQSQVYG-EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPL-FMKMT 119 P+ ++ +Q Q G F T L G E + F +P+ K Sbjct: 20 PYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAA-EIFYDTTR-FEREGAMPVAIQKTL 77 Query: 120 KMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDF 179 G + G +++ + ++ E + + F Sbjct: 78 FGQGGVQGLDGETHRHRKQMFMGLMTP--ERVRALAQLFEAEWRRAVPGW--TRKGEIVF 133 Query: 180 KQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILP 239 + ++ D + + + A SAS P Sbjct: 134 YDELHEPLTRAVCAW---AGVPLPDDEAGNRAGELRALFDAAGSAS-------------P 177 Query: 240 FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKEN 299 +L R V + R+IE + ++ S Sbjct: 178 RHLWSRLAR--RRVDAWAKRIIEGIRAG----SIGSGSGTAAYAIAWHRDRHDDLLSPHV 231 Query: 300 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 359 + ++ + + + I+ + ++ D Sbjct: 232 AAVELVNVLRPTVAIAVY-ITFVAHALQTCSGIRAALVQQPD------------------ 272 Query: 360 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 419 Y E + EV RF P + S+D G + P+G V+ +LY + D W DP+ Sbjct: 273 YAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 420 FHPERFLDSSGYFAKKEALVPFSLGR----RHCLGEHLARMEMFLFFTALLQRFHLHFPH 475 F PERF + +P G C GE + M + L+ P Sbjct: 332 FRPERF---RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPD 388 Query: 476 ELVP------DLKPRLGMTLQ 490 + + P+ G ++ Sbjct: 389 QDLSIDFARLPALPKSGFVMR 409 >2RCM-A nrPDB Length = 495 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 59/152 (38%), Gaps = 13/152 (8%) Query: 331 NIQGQVQKEIDLIMGPNG-KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV 389 + ++ +EI ++ NG + + KM T++V++E LRF V +D V+ Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVI 374 Query: 390 RGY----SIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFS--- 442 + + G + D K + + F PERF+ G + L Sbjct: 375 ESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPET 434 Query: 443 ----LGRRHCLGEHLARMEMFLFFTALLQRFH 470 +G + C G+ + LF + +R+ Sbjct: 435 ETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 71.3 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 74/470 (15%), Positives = 139/470 (29%), Gaps = 73/470 (15%) Query: 41 PGPPGLPF---IGNIYSLAASSELPHVYMRKQSQVY-GEIFSLDLGGIS-------TVVL 89 PG G+PF I + + Y R + Q Y +F ++ +VL Sbjct: 12 PGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVL 71 Query: 90 NGYDVVKECL----VHQSEIFADRPCLPLFMKMTKMGGLLN--SRYGRGWVDHRRLAVNS 143 V + ++F K+T +L+ + L Sbjct: 72 LDAKSFPILFDVSKVEKKDLFTG--TYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLL--- 126 Query: 144 FRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYE 203 F + S I + + + E + + N V G + Sbjct: 127 ---FFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNS 183 Query: 204 DTDFQHMIELFSENVELAASASV--FLYNAFPWIGILPFGKHQQL-----FRNAAVVYDF 256 + + + + ++ L PW P +L +YD+ Sbjct: 184 NPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDY 243 Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT- 315 + K + N++F+V G + Sbjct: 244 FQSVATPVME------------------QAEKLGVPKDEAVHNILFAVCFNTFGGVKILF 285 Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGP--NGKPSWDDKCKMPYTEAVLHEVLRFCN 373 N L+W L + Q + +EI + +G + + +MP T++V++E LR Sbjct: 286 PNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEP 342 Query: 374 IVPLGIFHATSEDAVVRGYS----IPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429 VP + + + + KG + D K + PE + P+RF+ Sbjct: 343 PVPPQYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDG 401 Query: 430 GYFAKKEALVPFSLGR---------RHCLGEHLARMEMFLFFTALLQRFH 470 K V +S G + C G+ + LF L +R+ Sbjct: 402 EALLK---YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 60.9 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 48/131 (36%), Gaps = 20/131 (15%) Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367 + AG E T N + A+L ++ P + ++ + + + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPA------------------AAQRTVAE 261 Query: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427 VLR + L + + + + I +G V+ + + + D + + +P+ +R D Sbjct: 262 VLRLHPALHLE-RRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR-PD 319 Query: 428 SSGYFAKKEAL 438 + + Sbjct: 320 ADRALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 35.5 bits (80), Expect = 0.050, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 55/153 (35%), Gaps = 26/153 (16%) Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312 V ++ ++ + + P LD++ + + ++ +V + + G Sbjct: 77 VEHLINPILNSLNEEQPKNNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGGG- 135 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372 ++ G +Q +IDLIM K + + + T + E+LR Sbjct: 136 ------------------DVSGAMQ-DIDLIMDIPVKLTVE----LGRTRMTIKELLRLT 172 Query: 373 NIVPLGIFHATSE--DAVVRGYSIPKGTTVITN 403 + + E D ++ GY I +G V+ Sbjct: 173 QGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 205 >4YXB-D nrPDB Length = 80 Score = 32.8 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 21/49 (42%), Gaps = 2/49 (4%) Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSE--DAVVRGYSIPKGTTVITN 403 ++ T + E+LR + + E D ++ GY I +G V+ Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >2B24-A nrPDB Length = 470 Score = 32.0 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 24/162 (14%), Positives = 42/162 (25%), Gaps = 15/162 (9%) Query: 245 QLFRNAAVVYDFLSRLIEKASVNRKPQLPQ-----HFVDAYLDEMDQGKNDPSSTFSKEN 299 + N A + ++ + + + L V D Q P N Sbjct: 143 RPMPNLASYKGLIFGSLDPHADSLEDYLGDLKFYLDIVLDRSDAGLQVVGAPQRWVIDAN 202 Query: 300 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKE------IDLIMGPNGKPSWD 353 + T L +A P+ Q + E + P Sbjct: 203 WKLGADNFVGDAYHTMMTHRSMVELGLA-PPDPQFALYGEHIHTGHGHGLGIIGPPPGMP 261 Query: 354 DKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIP 395 M E ++ E+ R + IF T+ + G P Sbjct: 262 LPEFMGLPENIVEELERRLTPEQVEIFRPTA---FIHGTVFP 300 >5L9W-B nrPDB Length = 732 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 19/147 (12%), Positives = 47/147 (31%), Gaps = 6/147 (4%) Query: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256 G++ + I++ + + L P IG+L H+ Sbjct: 56 GDKVGLSVEELLPRIDII--RYSTTVALNRLLQRQGPRIGLLTTEGHEDAILIGRGAQWT 113 Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSS----TFSKENLIFSVGELIIAGT 312 + + + P ++ L + + D S +E++ + L+ G Sbjct: 114 DGQRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGA 173 Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKE 339 L W+ + A ++ +++E Sbjct: 174 RAIVVSLLWSFMNPAHEKRVREIIREE 200 >3RP9-A nrPDB Length = 458 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 8/55 (14%), Positives = 19/55 (34%), Gaps = 3/55 (5%) Query: 327 ALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP---YTEAVLHEVLRFCNIVPLG 378 +P + E++ + ++D M A + E+ R+ + L Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLP 449 >2BKC-A nrPDB Length = 156 Score = 29.7 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 49/142 (34%), Gaps = 20/142 (14%) Query: 176 PFDFKQLITNAVSNITNLIIFGERFTY-----EDTDFQHMIELFSENVELAASASVFLYN 230 D K+ + + V+N L +F + +F + E + + Sbjct: 6 SVDTKEFLNHQVAN---LNVFTVKIHQIHWYMRGHNFFTLGEKMDDLYSEFGEQMDEVAE 62 Query: 231 AFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290 IG PF ++ NA+ +E+A KP+ ++ + ++ +++ Sbjct: 63 RLLAIGGSPFSTLKEFLENAS---------VEEAPYT-KPKTMDQLMEDLVGTLELLRDE 112 Query: 291 --PSSTFSKENLIFSVGELIIA 310 + + +++IA Sbjct: 113 YKQGIELTDKEGDDVTNDMLIA 134 >4CIU-A nrPDB Length = 727 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 26/124 (20%), Positives = 45/124 (36%), Gaps = 11/124 (8%) Query: 168 AIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVF 227 + +GR DF+ + SN+ + ERF D + HM EL V F Sbjct: 556 RLTDGQGRTVDFRNTVVIMTSNL-GSDLIQERFGELD--YAHMKELVLGVVSHNFRPE-F 611 Query: 228 LYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 287 + + P G+ ++ A + + + K R ++ H D L + + Sbjct: 612 INRIDEVVVFHPLGE-----QHIASIAQIQLKRLYKRLEERGYEI--HISDEALKLLSEN 664 Query: 288 KNDP 291 DP Sbjct: 665 GYDP 668 >3RFT-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 17/55 (30%), Gaps = 11/55 (20%) Query: 402 TNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456 S + Y+ E P+ G G C GE+LARM Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL-----------YGVSKCFGENLARM 149 >3EUH-A nrPDB Length = 440 Score = 28.2 bits (61), Expect = 8.1, Method: Composition-based stats. Identities = 39/314 (12%), Positives = 86/314 (27%), Gaps = 60/314 (19%) Query: 158 ILEETKFFNDAIETYKGR---PFD-FKQLITNAVSNITNLIIFGERFTYEDTD------F 207 + P D L+ A N GER E ++ F Sbjct: 4 FSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLN-------GERLDGEMSEGELVDAF 56 Query: 208 QHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQ-----LFRNAAVVYDFLSRLIE 262 +H+ + F + E + N +L +Q ++R + I Sbjct: 57 RHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIR 116 Query: 263 KAS-VNRKPQLPQHFVDAYLDEMDQGKNDPSSTFS-KENLIFSVGELIIAGTETTTNVLR 320 + + + V L + F N+ L+ Sbjct: 117 QREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYA---------------PLK 161 Query: 321 WAILFMALYPNIQGQVQKEIDLIMGPN--GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378 +++ + ++ ++ E + + + D + + E +L E G Sbjct: 162 YSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSET--------SG 213 Query: 379 IFHATSEDAVVRGYSIPKGTTVITNL-----YSVHFDEKYWRDPEVFHPERFLDSSGYFA 433 ++ G + NL ++ D+ ++ D VF + LD + Sbjct: 214 TLR------ELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWG 267 Query: 434 KKEALVPFSLGRRH 447 ++ + R Sbjct: 268 QQSIDLWIGYDRHV 281 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.129 0.345 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,316,366 Number of Sequences: 36641 Number of extensions: 763847 Number of successful extensions: 3619 Number of sequences better than 10.0: 178 Number of HSP's better than 10.0 without gapping: 266 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 2578 Number of HSP's gapped (non-prelim): 367 length of query: 501 length of database: 10,336,785 effective HSP length: 101 effective length of query: 400 effective length of database: 6,636,044 effective search space: 2654417600 effective search space used: 2654417600 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (20.9 bits) S2: 61 (28.1 bits)