BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q6PI48 (645 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4AH6-A nrPDB 1253 0.0 1IL2-A nrPDB 436 e-122 4RMF-A nrPDB 435 e-122 4WJ3-M nrPDB 429 e-120 1EFW-A nrPDB 427 e-120 5W25-A nrPDB 418 e-117 1WYD-A nrPDB 120 2e-27 3NEM-A nrPDB 105 9e-23 1N9W-A nrPDB 97 2e-20 1BBU-A nrPDB 86 6e-17 3A74-A nrPDB 84 3e-16 1LYL-A nrPDB 80 3e-15 4J15-A nrPDB 79 5e-15 6OD8-A nrPDB 79 7e-15 5HGQ-A nrPDB 75 6e-14 1X54-A nrPDB 75 1e-13 6CHD-A nrPDB 75 1e-13 6ILH-A nrPDB 74 2e-13 4EX5-A nrPDB 74 3e-13 5ELO-A nrPDB 73 4e-13 6AQG-A nrPDB 72 1e-12 4UP8-A nrPDB 72 1e-12 1ASZ-A nrPDB 70 4e-12 6NRZ-A nrPDB 64 2e-10 3M4P-A nrPDB 64 2e-10 3I7F-A nrPDB 62 6e-10 5XIX-A nrPDB 60 3e-09 4YCV-A nrPDB 60 4e-09 6AQH-A nrPDB 60 4e-09 5GRO-A nrPDB 58 1e-08 5ZG8-A nrPDB 56 4e-08 2XGT-A nrPDB 55 1e-07 3G1Z-A nrPDB 44 2e-04 3A5Z-A nrPDB 43 4e-04 1NNH-A nrPDB 38 0.015 3P8T-A nrPDB 37 0.034 5EJY-A nrPDB 32 1.2 1ZN9-A nrPDB 31 1.3 5LL6-h nrPDB 31 1.5 5X0Z-E nrPDB 30 2.5 6HIV-DP nrPDB 30 3.9 6EHO-A nrPDB 28 9.8 >4AH6-A nrPDB Length = 617 Score = 1253 bits (3243), Expect = 0.0, Method: Compositional matrix adjust. Identities = 605/605 (100%), Positives = 605/605 (100%) Query: 41 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA 100 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA Sbjct: 2 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA 61 Query: 101 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK 160 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK Sbjct: 62 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK 121 Query: 161 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP 220 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP Sbjct: 122 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP 181 Query: 221 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ 280 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ Sbjct: 182 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ 241 Query: 281 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK 340 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK Sbjct: 242 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK 301 Query: 341 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL 400 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL Sbjct: 302 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL 361 Query: 401 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 460 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA Sbjct: 362 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 421 Query: 461 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 520 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK Sbjct: 422 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 481 Query: 521 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG 580 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG Sbjct: 482 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG 541 Query: 581 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK 640 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK Sbjct: 542 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK 601 Query: 641 AERAH 645 AERAH Sbjct: 602 AERAH 606 >1IL2-A nrPDB Length = 590 Score = 436 bits (1122), Expect = e-122, Method: Compositional matrix adjust. Identities = 242/602 (40%), Positives = 349/602 (57%), Gaps = 24/602 (3%) Query: 49 VRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKK 105 +RT CG+LR SH+GQ+VTLCGW+ RR F+ +RD +G+VQV D A K Sbjct: 1 MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDR--ADALK 58 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKK 165 + E E +QV+GTV +R N M TGEIE+ + ++N LP + N V Sbjct: 59 LASELRNEFCIQVTGTVRARDEKNINRDMATGEIEVLASSLTIINRADVLPLD-SNHVNT 117 Query: 166 TEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKE 225 EA RL+YRYLDLR +M L+ R+++ +R ++ + HGF+DIETP L K TP GA++ Sbjct: 118 EEA-RLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDD-HGFLDIETPMLTKATPEGARD 175 Query: 226 FLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIE 284 +LVPSR GKFY+LPQSPQ FKQLLM+ G DRY+Q+ +C+RDE R DRQPEFTQID+E Sbjct: 176 YLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVE 235 Query: 285 MSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDI 344 SF+ ++ ++E L+++ W K + FP MTFAE YG+DKPD R M++ D+ Sbjct: 236 TSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDV 295 Query: 345 SDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFL 404 +D+ ++ E + P G V A+ +P GA L RK I+ NF + + + + + Sbjct: 296 ADLLKSVEFAVFAGPANDPKGRVAALRVPGGAS-LTRKQIDEYGNFVKIYGAKGLAYIKV 354 Query: 405 NAN----RNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 460 N NSPVA F+ +++ Q+ D++ A +G LRL+ Sbjct: 355 NERAKGLEGINSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKKIVADAMGALRLKVG 414 Query: 461 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 520 + + L D + ++ LWV+DFP+F +++ L + HHPFT+P L P+ Sbjct: 415 -----KDLGLTDESKWAPLWVIDFPMF--EDDGEGGLTAMHHPFTSPKDMTAAELKAAPE 467 Query: 521 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQALDYGAPP 577 A + YD+V+NG E+GGGS+RIHN ++Q+ + L +E + LL AL YG PP Sbjct: 468 NAVANAYDMVINGYEVGGGSVRIHNGDMQQTVFGILGINEEEQREKFGFLLDALKYGTPP 527 Query: 578 HGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPT 637 H G+A GLDRL L+TG+ +IRDVIAFPK+ LM+ P P L I+V K Sbjct: 528 HAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANPTALAELSIQVVKKA 587 Query: 638 DS 639 ++ Sbjct: 588 EN 589 >4RMF-A nrPDB Length = 609 Score = 435 bits (1118), Expect = e-122, Method: Compositional matrix adjust. Identities = 242/609 (39%), Positives = 351/609 (57%), Gaps = 36/609 (5%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVK 104 ++RT+ G LR + GQ VTL GW+ RR + F+ LRD G+ QV+ + + A+ Sbjct: 1 MLRTHAAGSLRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGDVLAAAH 60 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 ++ E V V+G V RP G ENP++PTG+IE+ +L LPF++ + Sbjct: 61 RLRAE----FCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESAPLPFQLDE--Q 114 Query: 165 KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAK 224 E RL+YRYLDLR LRLRS++ R L H FV+IETPTL + TP GA+ Sbjct: 115 AGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAE-HDFVEIETPTLTRSTPEGAR 173 Query: 225 EFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 283 +FLVP+R +PG FY+LPQSPQ FKQLLMV G++RY+Q+ARCYRDE R DRQPEFTQ+D+ Sbjct: 174 DFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDM 233 Query: 284 EMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIID 343 EMSFV+ + ++ E +L+ W + +P P +++ E + +G+DKPD RFG+++++ Sbjct: 234 EMSFVEADDVIAISEQVLKAVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRFGIELVE 293 Query: 344 ISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVF 403 ++ F++T Q P+ V A+ +P GA R+ ++ + FA ++ + V Sbjct: 294 CTEYFKDTTFRVFQ----APY--VGAVVMPGGASQ-PRRTLDGWQEFAKQRGHKGLAYVL 346 Query: 404 LNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLL 463 + + PVA + +++R L+ + D + AG A +LLG R+E A L Sbjct: 347 VGEDGTLGGPVAKNLSDAERDGLVAHVGANPGDCIFFAAGPAKGARALLGATRIEIAKRL 406 Query: 464 ETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESA---------HHPFTAPHPSDIHL 514 + L DP ++F WVVDFP+F +E + A HH FTAP P + Sbjct: 407 D-----LIDPNAWAFTWVVDFPMFEAADEATAAGDVAVGSGAWTAMHHAFTAPKPDSVDT 461 Query: 515 LYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQAL 571 ++P A S YD+V NGNEIGGGSIRIH ++Q + A + E + LL A Sbjct: 462 FDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFLLDAF 521 Query: 572 DYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHI 631 YGAPPHGGIA G DR+ L+ G SIR+VIAFPKS G D +++ P + P++ K I Sbjct: 522 SYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDPLTDAPAPITPQQRKESGI 581 Query: 632 RVSKPTDSK 640 +KP + K Sbjct: 582 D-AKPREDK 589 >4WJ3-M nrPDB Length = 599 Score = 429 bits (1102), Expect = e-120, Method: Compositional matrix adjust. Identities = 238/597 (39%), Positives = 351/597 (58%), Gaps = 24/597 (4%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVK 104 ++R++ CG+L S GQEVTLCGW+ RR + FL +RD +GL QV+ D + K Sbjct: 9 MMRSHYCGQLNESLDGQEVTLCGWVHRRRDHGGVIFLDVRDREGLAQVVFDPDRAETFAK 68 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 + E VV+++G V RP G NP M +G IE+ E+LN + PF + + Sbjct: 69 ADRVRS--EFVVKITGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSD 126 Query: 165 KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAK 224 E RL+YR++DLR +M L+LR+++ +R YL + +GF+D+ETP L + TP GA+ Sbjct: 127 VGEETRLRYRFIDLRRPEMAAKLKLRARITSSIRRYLDD-NGFLDVETPILGRPTPEGAR 185 Query: 225 EFLVPSRE-PGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 283 ++LVPSR PG F++LPQSPQ FKQLLMV G DRY+Q+A+C+RDE R DRQPEFTQIDI Sbjct: 186 DYLVPSRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDI 245 Query: 284 EMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIID 343 E SF+D++ I + E +++ + D FP M F E + YG+DKPD R ++++D Sbjct: 246 ETSFLDESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVD 305 Query: 344 ISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVF 403 ++D + E + P G V A+ +P GA + R I+ F + + + + Sbjct: 306 VADQLKEVEFKVFSGPANDPKGRVAALRVP-GAASMPRSQIDDYTKFVGIYGAKGLAYIK 364 Query: 404 LNAN----RNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLEC 459 +N SP+ FI E+ ++ + + D+V A + C LG LR++ Sbjct: 365 VNERAKGVEGLQSPIVKFIPEANLNVILDRVGAVDGDIVFFGADKAKIVCDALGALRIKV 424 Query: 460 ADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEP 519 L+ ++ R+ ++ +WVVDFP+F +E + L + HHPFT+P + L P Sbjct: 425 GHDLK---LLTRE---WAPMWVVDFPMF--EENDDGSLSALHHPFTSPKCTPAE-LEANP 475 Query: 520 KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQALDYGAP 576 A S+ YD+VLNG E+GGGSIRIH+ +Q+ + L E + LL AL YGAP Sbjct: 476 GAALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLLDALKYGAP 535 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRV 633 PHGG+A GLDRL+ L+TG+ SIR+VIAFPK+ D+M+ P SV + L+ HIR+ Sbjct: 536 PHGGLAFGLDRLVMLMTGASSIREVIAFPKTQSAGDVMTQAPGSVDGKALRELHIRL 592 >1EFW-A nrPDB Length = 580 Score = 427 bits (1097), Expect = e-120, Method: Compositional matrix adjust. Identities = 261/602 (43%), Positives = 366/602 (60%), Gaps = 39/602 (6%) Query: 50 RTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVII-PQDESAASVKK 105 RT+ G LR +H+G+EV L GW+ RR FL LRD +GLVQ++ P + A+ ++ Sbjct: 3 RTHYAGSLRETHVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVAHPASPAYATAER 62 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK- 164 + E VV+ G V RP + NP++ TG +E+++ E+L K PF + + Sbjct: 63 VRPE----WVVRAKGLVRLRP--EPNPRLATGRVEVELSALEVLAEAKTPPFPVDAGWRG 116 Query: 165 -----KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRT 219 +E LRL+YRYLDLR +MQ NLRLR +++ + ++L + GFV +ETP L K T Sbjct: 117 EEEKEASEELRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFL-DREGFVQVETPFLTKST 175 Query: 220 PGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEF 278 P GA++FLVP R EPG FY+LPQSPQ FKQ+LMV GLDRYFQ+ARC+RDE R DRQP+F Sbjct: 176 PEGARDFLVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPDF 235 Query: 279 TQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKD-PVVVPFPTMTFAEVLATYGTDKPDTRF 337 TQ+D+EMSFV+ + L E L+ + + + +PFP +++ E + YG+DKPD RF Sbjct: 236 TQLDLEMSFVEVEDVLELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLRF 295 Query: 338 GMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQ 397 G+++ ++ +FR + Q+A S VKA+ +P K L RK++ + A H Q Sbjct: 296 GLELKEVGPLFRQSGFRVFQEAES-----VKALALP---KALSRKEVAELEEVAKRHKAQ 347 Query: 398 EILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRL 457 + + ++ VA F +E R L++ E + D +L AG A + LG +RL Sbjct: 348 GLAWARVEEG-GFSGGVAKF-LEPVREALLQATEARPGDTLLFVAGPRKVAATALGAVRL 405 Query: 458 ECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYT 517 ADLL + R+ F FLWVVDFPL L +E HHPFT+PHP D+ LL Sbjct: 406 RAADLLGLK----REG--FRFLWVVDFPL-LEWDEEEEAWTYMHHPFTSPHPEDLPLLEK 458 Query: 518 EPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQALDYG 574 +P + R+ YDLVLNG E+GGGSIRIH+ LQ + L +E + L+AL+YG Sbjct: 459 DPGRVRALAYDLVLNGVEVGGGSIRIHDPRLQARVFRLLGIGEEEQREKFGFFLEALEYG 518 Query: 575 APPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVS 634 APPHGGIA GLDRL+ L+TGSPSIR+VIAFPK+ G D ++ P VP E+L+ + V Sbjct: 519 APPHGGIAWGLDRLLALMTGSPSIREVIAFPKNKEGKDPLTGAPSPVPEEQLRELGLMVV 578 Query: 635 KP 636 +P Sbjct: 579 RP 580 >5W25-A nrPDB Length = 616 Score = 418 bits (1075), Expect = e-117, Method: Compositional matrix adjust. Identities = 241/606 (39%), Positives = 345/606 (56%), Gaps = 42/606 (6%) Query: 47 FVVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVII--PQDESAA 101 FV+R++ G LR GQ+VTL GW+ RR + F+ LRD G+ QV+ PQD Sbjct: 22 FVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVFRDPQD---- 77 Query: 102 SVKKILCEAP---VESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFE 158 ++L +A E V V+G V RP G NP++ TGEIE+ + +L C LPF+ Sbjct: 78 --TEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQ 135 Query: 159 IKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR 218 + E LRL+YRYLDLR +RLRS++ R L H FV+IETPT+ + Sbjct: 136 LDE--PAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLAR-HDFVEIETPTITRS 192 Query: 219 TPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPE 277 TP GA++FLVP+R PG FY+LPQSPQ FKQLLMV G++RY+Q+ARCYRDE R DRQPE Sbjct: 193 TPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPE 252 Query: 278 FTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRF 337 FTQ+D+EMSFVD I ++ E +L W + P P + +AE + +GTDKPD RF Sbjct: 253 FTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRF 312 Query: 338 GMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQ 397 G+++++ +D F +T Q P+ V A+ +P GA R+ ++ +++A ++ Sbjct: 313 GLELVECTDFFSDTTFRVFQ----APY--VGAVVMPGGASQ-PRRTLDGWQDWAKQRGHR 365 Query: 398 EILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRL 457 + V + + PVA + E++R L + + D + +AG + +LLG R+ Sbjct: 366 GLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARV 425 Query: 458 ECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESA---------HHPFTAPH 508 E A+ L L DP ++F+WVVD PLF P +E E A HH FTAP Sbjct: 426 EIANRLG-----LIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPK 480 Query: 509 PSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLS 565 P + ++ + YD+V NG+EIGGGS+RIH ++Q + A + E + Sbjct: 481 PEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFG 540 Query: 566 HLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEE 625 LL+A +GAPPHGGIA G DR L+ G SIR+VIAFPK+ G D +++ P + ++ Sbjct: 541 FLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQ 600 Query: 626 LKPYHI 631 K I Sbjct: 601 RKESGI 606 >1WYD-A nrPDB Length = 429 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 88/259 (33%), Positives = 137/259 (52%), Gaps = 20/259 (7%) Query: 50 RTNTCGELRSSHLGQEVTLCGWIQYRRQ---NTFLVLRDFDGLVQVIIPQDESAASVKKI 106 R++ ++ + G+EV GW+ R F++LRD GL QV++ ++ SA + + Sbjct: 3 RSHFIADVTPEYDGKEVIWAGWVHLLRDLGGKKFIILRDKTGLGQVVVDKNSSAFGISQE 62 Query: 107 LCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKK-LPFEIKNFVKK 165 L + ESV+QV G V + + + P G IE+ + LL+ K LP ++ VK Sbjct: 63 LTQ---ESVIQVRGIV------KADKRAPRG-IELHAEEITLLSKAKAPLPLDVSGKVKA 112 Query: 166 TEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAK 224 RL+ R LDLR +MQ ++++S + RE L GF++I TP + T GGA+ Sbjct: 113 DIDTRLRERVLDLRRQEMQAVIKIQSLALKAFRETLYK-EGFIEIFTPKIIASATEGGAQ 171 Query: 225 EFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYR-DEGSRPDRQPEFTQIDI 283 L P GK L QSPQ +K+ LM G ++R F+VA +R +E P EF +D+ Sbjct: 172 --LFPVIYFGKEAFLAQSPQLYKE-LMAGVVERVFEVAPAWRAEESDTPFHLAEFISMDV 228 Query: 284 EMSFVDQTGIQSLIEGLLQ 302 EM+F D + L+E +L Sbjct: 229 EMAFADYNDVMQLLEKILH 247 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 8/108 (7%) Query: 504 FTAPHPSDIHLLYTEPKKAR---SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKED 560 F PSD YT+ K S+ +DL+ EI GS R H E+ + L K+ Sbjct: 318 FIVDWPSDARPFYTKSKSENPELSESFDLIYKFLEIVSGSTRNHKREV---LEEALKKKG 374 Query: 561 VK--MLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 +K L+ DYG PPH G +GL RL+ ++TG S+++++ FP+ Sbjct: 375 LKPESFEFFLKWFDYGMPPHAGFGMGLARLMVMLTGIQSVKEIVPFPR 422 >3NEM-A nrPDB Length = 438 Score = 105 bits (261), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 80/261 (30%), Positives = 128/261 (49%), Gaps = 15/261 (5%) Query: 50 RTNTCGELRSSHLGQEVTLCGWIQYRRQ---NTFLVLRDFDGLVQVIIPQDESAASVKKI 106 RT+ E+ GQ+V + GW+ + FL +RD DG+VQ+ P+ + + K+ Sbjct: 3 RTHYSSEITEELNGQKVKVAGWVWEVKDLGGIKFLWIRDRDGIVQITAPKKKVDPELFKL 62 Query: 107 LCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKT 166 + + E VV V G V PK G + K L A LP + VK Sbjct: 63 IPKLRSEDVVAVEGVV------NFTPKAKLGFEILPEKIVVLNRAETPLPLDPTGKVKAE 116 Query: 167 EALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKE 225 RL R++DLR ++ ++RS + +R++ +GF++I TP + T GG + Sbjct: 117 LDTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHE-NGFIEIHTPKIIATATEGGTEL 175 Query: 226 FLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIE 284 F + E F L QSPQ +KQ++M GLDR +++A +R E R E ID E Sbjct: 176 FPMKYFEEDAF--LAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWSIDSE 233 Query: 285 MSFV-DQTGIQSLIEGLLQYS 304 M+F+ D+ + S +E L+ ++ Sbjct: 234 MAFIEDEEEVMSFLERLVAHA 254 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 14/122 (11%) Query: 496 ELESAHHPFTAPHPSDIHLLY-----TEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQR 550 E E+A F +PS+ Y +P+ R+ +DL G EI G R H + Sbjct: 319 ENENAPLYFLYQYPSEAKPFYIMKYDNKPEICRA--FDLEYRGVEISSGGQREHRHD--- 373 Query: 551 YILATLLKE---DVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 IL +KE + + L+A YG PPHGG LG +RLI + P+IR+VI FP+ Sbjct: 374 -ILVEQIKEKGLNPESFEFYLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFPRD 432 Query: 608 FR 609 R Sbjct: 433 RR 434 >1N9W-A nrPDB Length = 422 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/251 (33%), Positives = 132/251 (52%), Gaps = 29/251 (11%) Query: 59 SSHLGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 +H+GQEV L G++ +RR + FL+LRD G+VQV+ +K L E S Sbjct: 9 KAHVGQEVELLGFLHWRRDLGRIQFLLLRDRSGVVQVV------TGGLKLPLPE----SA 58 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLN-ACKKLPFEI-KNFVKKTEALRLQY 173 ++V G V+ EN K P G +E++ K E+L+ A + P EI K + L+Y Sbjct: 59 LRVRGLVV------ENAKAPGG-LEVQAKEVEVLSPALEPTPVEIPKEEWRANPDTLLEY 111 Query: 174 RYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKEFLVPSRE 232 RY+ LR + + L++++ +V R YL + F +I TP + + GG+ F V E Sbjct: 112 RYVTLRGEKARAPLKVQAALVRGFRRYL-DRQDFTEIFTPKVVRAGAEGGSGLFGVDYFE 170 Query: 233 PGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFV-DQ 290 + L QSPQ +KQ +MVG +R ++VA +R E R E+ +D+EM F+ D+ Sbjct: 171 KRAY--LAQSPQLYKQ-IMVGVFERVYEVAPVWRMEEHHTSRHLNEYLSLDVEMGFIADE 227 Query: 291 TGIQSLIEGLL 301 + L E LL Sbjct: 228 EDLMRLEEALL 238 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 55/106 (51%), Gaps = 6/106 (5%) Query: 504 FTAPHPSDIHLLYTEPKK-ARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKE--D 560 F +P + YT P++ ++ +DL+ G EI G RIH E +L +L + D Sbjct: 313 FVTRYPRSVRPFYTYPEEDGTTRSFDLLFRGLEITSGGQRIHRYE---ELLESLKAKGMD 369 Query: 561 VKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 + L+ YG PPHGG A+G +RL + G P++R AFP+ Sbjct: 370 PEAFHGYLEVFKYGMPPHGGFAIGAERLTQKLLGLPNVRYARAFPR 415 >1BBU-A nrPDB Length = 504 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 123/249 (49%), Gaps = 21/249 (8%) Query: 62 LGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASV-KKILCEAPVESVVQ 117 L EV + G + RR + +F+ L+D G +Q+ + +D+ V + + + ++ Sbjct: 63 LNIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILG 122 Query: 118 VSGTVISRPAGQENPKMPTGEIEIKVKTAELLN-ACKKLPFEIKNFVKKTEALRLQYRYL 176 G + K TGE+ I LL A + LP + + + R + RYL Sbjct: 123 AKGKLF---------KTKTGELSIHCTELRLLTKALRPLPDKFHGL--QDQEARYRQRYL 171 Query: 177 DLRSFQMQYN-LRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREP 233 DL S N ++RSQ++ +R+++ N GF+++ETP + + PGGA + F+ Sbjct: 172 DLISNDESRNTFKVRSQILSGIRQFMVN-RGFMEVETP-MMQVIPGGAAARPFITHHNAL 229 Query: 234 GKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGI 293 L +P+ + + L+VGG +R F++ R +R+EG PEFT +++ M++ D + Sbjct: 230 DLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDL 289 Query: 294 QSLIEGLLQ 302 L E L + Sbjct: 290 IELTESLFR 298 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 31/89 (34%), Positives = 50/89 (56%), Gaps = 7/89 (7%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAE--LQRY---ILATLLKEDVKML--SHLLQALDYGAP 576 + ++ + G EIG G +++AE QR+ + A +D M + AL++G P Sbjct: 410 TDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLP 469 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFP 605 P G+ +G+DR++ L T S +IRDVI FP Sbjct: 470 PTAGLGIGIDRMVMLFTNSHTIRDVILFP 498 >3A74-A nrPDB Length = 493 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 120/245 (48%), Gaps = 18/245 (7%) Query: 65 EVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGT 121 EV + G I +R + F ++D G +Q+ + QD+ ++ + + +V V GT Sbjct: 58 EVAVAGRIMTKRGMGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGT 117 Query: 122 VISRPAGQENPKMPTGEIEIKVKTAELLN-ACKKLPFEIKNFVKKTEALRLQYRYLDL-R 179 + K GE+ IKV + E L A + LP E + +K E R + RYLDL Sbjct: 118 MF---------KTKVGELSIKVSSYEFLTKALRPLP-EKYHGLKDIEQ-RYRQRYLDLIM 166 Query: 180 SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA-KEFLVPSREPGKFYS 238 + + + RS ++ MR YL + HG++++ETP + G A + F+ Sbjct: 167 NPESKKTFITRSLIIQSMRRYLDS-HGYLEVETPMMHAVAGGAAARPFITHHNALDMTLY 225 Query: 239 LPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIE 298 + + + + L+VGGL++ +++ R +R+EG PEFT +++ ++ D I L E Sbjct: 226 MRIAIELHLKRLIVGGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTE 285 Query: 299 GLLQY 303 L+ + Sbjct: 286 NLIAH 290 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 40/112 (35%), Positives = 58/112 (51%), Gaps = 9/112 (8%) Query: 504 FTAPHPSDIH-LLYTEPKKAR-SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDV 561 F HP +I L P R + ++L + G E +++ QR LKE Sbjct: 378 FIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTELNDPIDQRQRFEEQLKERE 437 Query: 562 K-------MLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 + M L+AL+YG PP GG+ +G+DRL+ L+T SPSIRDV+ FP+ Sbjct: 438 QGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQ 489 >1LYL-A nrPDB Length = 504 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/249 (26%), Positives = 123/249 (49%), Gaps = 21/249 (8%) Query: 62 LGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASV-KKILCEAPVESVVQ 117 L EV++ G + RR + +F+ L+D G +Q+ + +D V + + ++ Sbjct: 63 LNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDSLPEGVYNDQFKKWDLGDIIG 122 Query: 118 VSGTVISRPAGQENPKMPTGEIEIKVKTAELLN-ACKKLPFEIKNFVKKTEALRLQYRYL 176 GT+ K TGE+ I LL A + LP + + + +R + RYL Sbjct: 123 ARGTLF---------KTQTGELSIHCTELRLLTKALRPLPDKFHGL--QDQEVRYRQRYL 171 Query: 177 DL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREP 233 DL + + + +RS+++ +R+++ GF+++ETP + + PGGA + F+ Sbjct: 172 DLIANDKSRQTFVVRSKILAAIRQFMV-ARGFMEVETP-MMQVIPGGASARPFITHHNAL 229 Query: 234 GKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGI 293 L +P+ + + L+VGG +R F++ R +R+EG PEFT +++ M++ D + Sbjct: 230 DLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYHDL 289 Query: 294 QSLIEGLLQ 302 L E L + Sbjct: 290 IELTESLFR 298 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 32/89 (35%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAE-----LQRYILATLLKEDVKML--SHLLQALDYGAP 576 + ++ + G EIG G +++AE Q + A +D M + AL+YG P Sbjct: 410 TDRFEFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAMFYDEDYVTALEYGLP 469 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFP 605 P G+ +G+DR+I L T S +IRDVI FP Sbjct: 470 PTAGLGIGIDRMIMLFTNSHTIRDVILFP 498 >4J15-A nrPDB Length = 521 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 111/240 (46%), Gaps = 28/240 (11%) Query: 71 WIQYRRQNT-------FLVLRDFDGLVQVIIP-QDESAASVKKILCEAPVESVVQVSGTV 122 W++ R + FLVLR VQ ++ D ++ + K ES+V V G V Sbjct: 81 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 140 Query: 123 ISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFVKK------------TEAL 169 R Q+ ++E+ V+ +++ + +LP ++ + V+ + Sbjct: 141 --RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 198 Query: 170 RLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKEFLV 228 RL R +DLR+ Q RL+S + RE L N GFV+I+TP + + GGA F V Sbjct: 199 RLDNRVIDLRTSTSQAVFRLQSGICHLFRETLIN-KGFVEIQTPKIISAASEGGANVFTV 257 Query: 229 PSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSF 287 + + L QSPQ +KQ+ + ++ F + +R E S R EF +DIEM+F Sbjct: 258 SYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAF 315 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 56/105 (53%), Gaps = 14/105 (13%) Query: 504 FTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAEL--QRYILATLLKEDV 561 +T P P + PK++ S YD+ + G EI G+ RIH+ +L +R + + D+ Sbjct: 422 YTMPDPRN-------PKQSNS--YDMFMRGEEILSGAQRIHDPQLLTERALHHGI---DL 469 Query: 562 KMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 + + + + +GAPPH G +GL+R+ L G ++R FP+ Sbjct: 470 EKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPR 514 >6OD8-A nrPDB Length = 558 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 106/221 (47%), Gaps = 21/221 (9%) Query: 79 TFLVLRDFDGLVQVIIP-QDESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTG 137 F+VLRD VQ + + + + + + ES+V V TV E P T Sbjct: 105 AFMVLRDGSDSVQAMAAVEGDVPKEMIDFMGQIATESIVDVEATVCK----VEQPITSTS 160 Query: 138 --EIEIKVKTAELLN-ACKKLPFEIKNFVKKTEA--------LRLQYRYLDLRSFQMQYN 186 +IE+KVK + + + LPF +++ +K A RL R++DLR+ Sbjct: 161 HSDIELKVKKIHTVTESLRTLPFTLEDASRKESAEGAKVNLDTRLNSRWMDLRTLASGAI 220 Query: 187 LRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKEFLVPSREPGKFYSLPQSPQQ 245 RL+S++ R++L + F +I +P + + GGA F + +F L QSPQ Sbjct: 221 FRLQSRVCQYFRQFLID-KDFCEIHSPKIINAPSEGGANVFKLEYF--NRFAYLAQSPQL 277 Query: 246 FKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEM 285 +KQ+++ G + R F+V +R E S R EF +D+EM Sbjct: 278 YKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLDVEM 318 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 45/83 (54%), Gaps = 1/83 (1%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIAL 583 + YD+ + G EI G+ RIH+ +L A +L D+ + + + GA PHGG + Sbjct: 470 TNSYDMFIRGEEISSGAQRIHDPDLL-LARAKMLNVDLTPIKEYVDSFRLGAWPHGGFGI 528 Query: 584 GLDRLICLVTGSPSIRDVIAFPK 606 GL+R++ L G ++R FP+ Sbjct: 529 GLERVVMLYLGLSNVRLASLFPR 551 >5HGQ-A nrPDB Length = 524 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 46/144 (31%), Positives = 79/144 (54%), Gaps = 5/144 (3%) Query: 161 NFVKKTEALRLQYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRT 219 +F K + R + RYLDL + ++ RS+M+ +R YL NL GF+++ETP + Sbjct: 151 HFGLKNQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNL-GFLEVETP-MMNLI 208 Query: 220 PGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPE 277 GGA K F+ + L +P+ + ++L+VGG+DR +++ R +R+EG PE Sbjct: 209 AGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPE 268 Query: 278 FTQIDIEMSFVDQTGIQSLIEGLL 301 FT + M++ D + + E +L Sbjct: 269 FTSCEFYMAYADYEDLMKITEDML 292 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 17/36 (47%), Positives = 26/36 (72%) Query: 570 ALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 AL+YG PP G +G+DRL ++T S +I++V+ FP Sbjct: 471 ALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFP 506 >1X54-A nrPDB Length = 434 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 123/255 (48%), Gaps = 17/255 (6%) Query: 54 CGELRSSHLGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEA 110 C E++ G++V L GW+ + FL +RD G+VQ ++ ++ + + Sbjct: 7 CQEVKPELDGKKVRLAGWVYTNMRVGKKIFLWIRDSTGIVQAVVAKNVVGEETFEKAKKL 66 Query: 111 PVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALR 170 ES V V G V + + + P G E+ V+ E++ A + P +N + + L Sbjct: 67 GRESSVIVEGIV------KADERAPGG-AEVHVEKLEVIQAVSEFPIP-ENPEQASPELL 118 Query: 171 LQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVP 229 L YR+L +R+ + ++++ ++M RE+L G+ ++ P L GGA F + Sbjct: 119 LDYRHLHIRTPKASAIMKVKETLIMAAREWLLK-DGWHEVFPPILVTGAVEGGATLFKLK 177 Query: 230 SREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFV 288 + K+ L QS Q + + + GL++ + + +R E SR R EF +++E +++ Sbjct: 178 YFD--KYAYLSQSAQLYLEAAIF-GLEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAWM 234 Query: 289 DQTGIQSLIEGLLQY 303 D I + E L+ Y Sbjct: 235 DLWDIMKVEEELVSY 249 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 10/111 (9%) Query: 504 FTAPHPSDIHLLY-----TEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK 558 F +P I Y +P+K + EI GGS R + + +L +L+ Sbjct: 321 FVYGYPKHIKAFYMKEDPNDPRKVLASDMLAPEGYGEIIGGSQREDDYD---KLLNRILE 377 Query: 559 E--DVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 E D K L YG+ PH G LG++RL+ V IR FP++ Sbjct: 378 EGMDPKDYEWYLDLRRYGSVPHSGFGLGVERLVAWVLKLDHIRWAALFPRT 428 >6CHD-A nrPDB Length = 597 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/178 (31%), Positives = 93/178 (52%), Gaps = 9/178 (5%) Query: 129 QENP-KMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDL--RSFQMQY 185 Q NP K GE+ I LL+ C + + +F K + R + RYLDL F Q Sbjct: 185 QGNPGKTKKGELSIIPYEITLLSPCLHMLPHL-HFGLKDKETRYRQRYLDLILNDFVRQ- 242 Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFYSLPQSP 243 +RS+++ +R +L L GF++IETP + PGGA K F+ E + +P Sbjct: 243 KFIIRSKIITYIRSFLDEL-GFLEIETP-MMNIIPGGAVAKPFITYHNELDMNLYMRIAP 300 Query: 244 QQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLL 301 + + ++L+VGG+DR +++ R +R+EG PEFT + M++ D + + E ++ Sbjct: 301 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 358 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 9/111 (8%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYIL-----ATL 556 F HP + L + K+ ++ ++L + EI +++ QR + A Sbjct: 461 FICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKA 520 Query: 557 LKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 +D M + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 521 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 >6ILH-A nrPDB Length = 521 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/178 (31%), Positives = 92/178 (51%), Gaps = 9/178 (5%) Query: 129 QENP-KMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDL--RSFQMQY 185 Q NP K GE+ I LL+ C + + +F K + R + RYLDL F Q Sbjct: 117 QGNPGKTKKGELSIIPYEITLLSPCLHMLPHL-HFGLKDKETRYRQRYLDLILNDFVRQ- 174 Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFYSLPQSP 243 +RS+++ +R +L L GF++IETP + PGGA K F+ E + +P Sbjct: 175 KFIIRSKIITYIRSFLDEL-GFLEIETP-MMNIIPGGAVAKPFITYHNELDMNLYMRIAP 232 Query: 244 QQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLL 301 + + ++L+VGG+DR +++ R +R+EG PEFT + M++ D + E ++ Sbjct: 233 ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDHMEITEKMV 290 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 9/111 (8%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYIL-----ATL 556 F HP + L + K+ ++ ++L + EI +++ QR + A Sbjct: 393 FICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKA 452 Query: 557 LKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 +D M + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 453 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 503 >4EX5-A nrPDB Length = 529 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 74/327 (22%), Positives = 137/327 (41%), Gaps = 46/327 (14%) Query: 65 EVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGT 121 EV + G + +R + +F ++D G +Q + + A + + +V G Sbjct: 88 EVAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGV 147 Query: 122 VISRPAGQENPKMPTGEIEIKVKTAELL-NACKKLPFEIKNFVKKTEALRLQYRYLDL-R 179 + + GE+ +K LL A + LP + + R + RY+DL Sbjct: 148 LF---------RTNKGELSVKCTQLRLLAKALRPLPDKFHGLADQE--TRYRQRYVDLIV 196 Query: 180 SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFY 237 + + + R R++ + +R+++ + F+++ETP L PGGA K F+ Sbjct: 197 TPETRTTFRARTKAIASIRKFMGDAD-FMEVETPMLHP-IPGGAAAKPFVTHHNALDMEM 254 Query: 238 SLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVD-------- 289 L +P+ + + L+VGG +R F++ R +R+EG P PEFT ++ ++ D Sbjct: 255 FLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFT 314 Query: 290 -----QTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKI--- 341 Q + +L +QY + + PF +T + + Y D + Sbjct: 315 ERLIRQAAVDALGTATIQYQ--GRELDLAQPFHRLTITQAIQKYAPSYTDGQLSDDAFLR 372 Query: 342 -------IDISD-VFRNTEIGFLQDAL 360 +D++ F N IG LQ AL Sbjct: 373 SELKRLGVDVTQPAFLNAGIGALQLAL 399 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 32/93 (34%), Positives = 52/93 (55%), Gaps = 15/93 (16%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKML-----------SHLLQALD 572 ++ ++L + G EI G +++ E Q A K+ V+ + ++AL+ Sbjct: 435 TERFELFITGREIANGFSELNDPEDQ----AARFKKQVEQKDAGDEEAMFFDADYIRALE 490 Query: 573 YGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 YG PP GG +G+DRL+ L+T SP+IRDV+ FP Sbjct: 491 YGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFP 523 >5ELO-A nrPDB Length = 535 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/172 (30%), Positives = 90/172 (52%), Gaps = 6/172 (3%) Query: 133 KMPTGEIEIKVKTAELLNAC-KKLPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLR 190 K GE+ + K+ LL+ C LP I K + +R + RYLDL + + + +LR Sbjct: 138 KSKRGELSLFSKSVVLLSPCYHMLPTAISGL--KDQEVRYRQRYLDLMLNEESRKVFKLR 195 Query: 191 SQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQL 249 S+ + +R Y L GF+++ETP L G A + F+ E + +P+ + + Sbjct: 196 SRAIKYIRNYFDRL-GFLEVETPMLNMIYGGAAARPFITYHNELETQLYMRIAPELYLKQ 254 Query: 250 LMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLL 301 L+VGGLD+ +++ + +R+EG PEFT ++ M++ D + L E L+ Sbjct: 255 LIVGGLDKVYEIGKNFRNEGIDLTHNPEFTAMEFYMAYADYYDLMDLTEELI 306 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 18/36 (50%), Positives = 25/36 (69%) Query: 570 ALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 AL++G PP GG LG+DRLI + +I++VI FP Sbjct: 482 ALEHGLPPTGGWGLGIDRLIMFLADKNNIKEVILFP 517 >6AQG-A nrPDB Length = 506 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 70/253 (27%), Positives = 116/253 (45%), Gaps = 27/253 (10%) Query: 50 RTNTCGELRSSHLG--------QEVTLCGWIQYRRQN---TFLVLRDFDGL-VQVIIPQD 97 RT+T E+R+++ V + G + + R F L+D DG +Q +I D Sbjct: 44 RTHTLAEIRATYADLPTDSATEDIVGVAGRVVFARNTGKLCFATLQDGDGTQLQAMISLD 103 Query: 98 ESA-ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLP 156 E S+ + + + VV V GTVIS G+ + + + K A + LP Sbjct: 104 EVGRESLDRWKADVDIGDVVYVHGTVISSRRGELSVLADSWRMAAK--------ALRPLP 155 Query: 157 FEIKNFVKKTEALRLQYRYLDLRSF-QMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTL 215 K +E R++ RY+DL Q + R R ++ +R L GF+++ETP L Sbjct: 156 VAHKEM---SEESRVRQRYVDLIVRPQAREVARQRIAVIRAVRNAL-ERRGFLEVETPML 211 Query: 216 FKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDR 274 G A + F+ S L +P+ F + +VGG DR F++ R +R+EGS Sbjct: 212 QTLAGGAAARPFVTHSNALDIDLYLRIAPELFLKRCIVGGFDRVFELNRVFRNEGSDSTH 271 Query: 275 QPEFTQIDIEMSF 287 PEF+ ++ ++ Sbjct: 272 SPEFSMLETYQTY 284 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 8/89 (8%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAELQR-------YILATLLKEDVKMLSHLLQALDYGAP 576 ++ +DL + G E+ G +++ +QR A E +++ L AL+YG P Sbjct: 412 TEKWDLYVRGVELATGYSELNDPVVQRDRFADQARAAAAGDDEAMQLDEDFLTALEYGMP 471 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFP 605 P G +G+DRL+ +TG SIR+ + FP Sbjct: 472 PCTGTGMGIDRLLMCLTGL-SIRETVLFP 499 >4UP8-A nrPDB Length = 777 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 44/135 (32%), Positives = 76/135 (56%), Gaps = 5/135 (3%) Query: 170 RLQYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEF 226 R + RYLDL + + N LR+++V +R+YL + GF+++ETP L PGGA + F Sbjct: 162 RFRKRYLDLIVNPESVKNFVLRTKVVKAVRKYLDD-KGFLEVETPIL-NTIPGGATARPF 219 Query: 227 LVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMS 286 + + + +P+ + + L+VGG++R +++ R +R+EG PEFT + M+ Sbjct: 220 ITHHNQLDIQMYMRIAPELYLKELVVGGINRVYEIGRLFRNEGIDQTHNPEFTTCEFYMA 279 Query: 287 FVDQTGIQSLIEGLL 301 + D I + E LL Sbjct: 280 YADYNDIMKMTEELL 294 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 7/89 (7%) Query: 524 SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKE------DVKMLSHL-LQALDYGAP 576 ++ ++L + EI ++N +QR K+ + +++ + L A+++ P Sbjct: 477 TERFELFILKREIANAYTELNNPIVQRSNFEQQAKDKAAGDDEAQLVDEVFLDAIEHAFP 536 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFP 605 P GG LG+DRL L+ +I++VI FP Sbjct: 537 PTGGWGLGIDRLAMLLADVDNIKEVILFP 565 >1ASZ-A nrPDB Length = 490 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 107/245 (43%), Gaps = 25/245 (10%) Query: 64 QEVTLCGWIQYRRQN----TFLVLRDFDGLVQVIIPQDESAASVKKILCEAP---VESVV 116 +EV + RQ FL LR L+Q ++ ++ K ++ A +ES+V Sbjct: 40 KEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIV 99 Query: 117 QVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEA-------- 168 V G V ++ + EI I K + + LP +++ ++EA Sbjct: 100 LVRGIVKKVDEPIKSATVQNLEIHI-TKIYTISETPEALPILLED-ASRSEAEAEAAGLP 157 Query: 169 -----LRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA 223 RL YR +DLR+ Q R+++ + REYL F ++ TP L G Sbjct: 158 VVNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLAT-KKFTEVHTPKLLGAPSEGG 216 Query: 224 KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQID 282 + GK Y L QSPQ KQ L+V +R +++ +R E S R EFT +D Sbjct: 217 SSVFEVTYFKGKAY-LAQSPQFNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLD 275 Query: 283 IEMSF 287 +EM+F Sbjct: 276 MEMAF 280 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 35/102 (34%), Positives = 47/102 (46%), Gaps = 4/102 (3%) Query: 509 PSDIHLLYTEPKKAR---SQHYDLVLNGNEIGGGSIRIHN-AELQRYILATLLKEDVKML 564 P +I YT P A S YD + G EI G+ RIH+ A LQ + A L + L Sbjct: 382 PLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLSPEDPGL 441 Query: 565 SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 YG PPH G +GL+R++ +IR FP+ Sbjct: 442 KDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFPR 483 >6NRZ-A nrPDB Length = 534 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 129/277 (46%), Gaps = 30/277 (10%) Query: 77 QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGTV-ISRPAGQENPKMP 135 +N F + D D +QV+ +D SA V + +A + + + + + G E Sbjct: 89 KNAFGQILDNDAKIQVMFNRDFSA--VAGLAADAGISPIKFIEKKLDLGDILGLEGYLFF 146 Query: 136 T--GEIEIKVKTAELLNACKKL-PFEIKNFVKKTEALRLQYRYLDLRSFQ-MQYNLRLRS 191 T GE+ + V+T LL CK L K+ + +R + R+ DL S + ++ RS Sbjct: 147 THSGELTVLVETVTLL--CKSLISLPDKHAGLADKEIRYRKRWADLISSEDVRKTFLTRS 204 Query: 192 QMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKE--FLVPSREPGKFYSLPQSPQQFKQL 249 +++ +REY+ + F+++ETP L + GGA+ F+ + L S + + Sbjct: 205 RILKLIREYM-DQQSFLEVETPIL-QTVYGGAEATPFVTTLQALHAEMFLRISLEIALKK 262 Query: 250 LMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQY---SWP 306 L+VGG+ R +++ + +R+EG PEFT I+ ++ D + +E L++Y + Sbjct: 263 LLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVENLVEYIVRALN 322 Query: 307 NDK----------DPVVVPFPT----MTFAEVLATYG 329 N + P VV F MT E ++ YG Sbjct: 323 NGETQVQYSHLKSGPQVVDFKAPWIRMTMKESISVYG 359 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 20/39 (51%), Positives = 28/39 (71%) Query: 567 LLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 L+AL G PP GG +G+DRL+ ++T + SIRDV+ FP Sbjct: 486 FLEALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFP 524 >3M4P-A nrPDB Length = 456 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 122/251 (48%), Gaps = 24/251 (9%) Query: 63 GQEVTLCGWIQY----RRQNTFLVLRDFDGLVQVIIPQDESAASVK-KILCEAPVESVVQ 117 G+ VT GW + R+ F+ LRD G Q +I E K K+L E ++ Sbjct: 30 GKLVTFKGWAYHIRKARKTLIFVELRDGSGYCQCVIFGKELCEPEKVKLLTR---ECSLE 86 Query: 118 VSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEAL--RLQYRY 175 ++G ++ AG+ +P + ++++ E + P +++N + K ++ ++Q R+ Sbjct: 87 ITGR-LNAYAGKNHPPEIADILNLEMQVTEW-KVIGESPIDLENIINKDSSIPQKMQNRH 144 Query: 176 LDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSREPG 234 + +RS Q L+LRS++ R+Y + H F +I+ PT+ K + GG+ F + Sbjct: 145 IVIRSEHTQQVLQLRSEIQWYFRKYYHDNH-FTEIQPPTIVKTQCEGGSTLFKL------ 197 Query: 235 KFYSLPQSPQQFKQLLM---VGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQ 290 ++++ P Q QL + + L + F + YR E SR R E+ ++ E+ F+ Sbjct: 198 QYFNEPAYLTQSSQLYLESVIASLGKSFCMLSSYRAEQSRTVRHLAEYLHLEAELPFISF 257 Query: 291 TGIQSLIEGLL 301 + + +E L+ Sbjct: 258 EDLLNHLEDLV 268 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/85 (37%), Positives = 44/85 (51%), Gaps = 4/85 (4%) Query: 524 SQHYDLVLNG-NEIGGGSIRIHNA-ELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGI 581 ++ DL++ G EI GGS+RI N EL A L D Q YG+ PHGG Sbjct: 367 TESVDLLMPGVGEIVGGSMRIWNYDELMGAYKANGLNPDPYYW--YTQQRKYGSCPHGGY 424 Query: 582 ALGLDRLICLVTGSPSIRDVIAFPK 606 LG++RL+ + G IR V +P+ Sbjct: 425 GLGVERLVMWLLGEDHIRKVCLYPR 449 >3I7F-A nrPDB Length = 548 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 5/132 (3%) Query: 160 KNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-R 218 + +VK ++ RL R LDLR+ R++S RE+L + FV+I TP L Sbjct: 217 QKYVKVSQDTRLDNRMLDLRTVTNIAIFRIQSACCGLFREFLTS-QKFVEIHTPKLIGCS 275 Query: 219 TPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PE 277 + GG+ F V + + L QSPQ +KQ+ ++G + F+V +R E S R E Sbjct: 276 SEGGSNIFEVKYFDRKAY--LAQSPQLYKQMAIMGDFRKVFEVGPVFRAENSNTRRHLTE 333 Query: 278 FTQIDIEMSFVD 289 F +DIEM V+ Sbjct: 334 FEGLDIEMEIVE 345 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 35/103 (33%), Positives = 53/103 (51%), Gaps = 8/103 (7%) Query: 509 PSDIHLLYTEPK---KARSQHYDLVLNGNEIGGGSIRIHNAE--LQRYILATLLKEDVKM 563 P+ I YT P S YD+ + G EI G+ RIH+ E ++R I + D Sbjct: 442 PAAIRPFYTMPDIDDPNYSNSYDVFVRGQEITSGAQRIHDPEFLMKRCIEKGV---DPAT 498 Query: 564 LSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 L +++ +G+ PH G +GL+R+ L G P+IR V FP+ Sbjct: 499 LKDYIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVTLFPR 541 >5XIX-A nrPDB Length = 472 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 113/250 (45%), Gaps = 21/250 (8%) Query: 60 SHLGQEVTLCGWI-QYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 + GQ V + GW+ + RRQ FLVLRD G +Q ++ DE +L ES Sbjct: 46 GYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVL-ADELCQCYNGVL--LSTESS 102 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQY-- 173 V V G + P G++ P G E+ EL+ + N + + + +Q Sbjct: 103 VAVYGMLNLTPKGKQAP----GGHELSCDFWELIGLAPAGGAD--NLINEESDVDVQLNN 156 Query: 174 RYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSRE 232 R++ +R M L+ RS + R++ + G+ ++ PTL + + GGA F + Sbjct: 157 RHMMIRGENMSKILKARSMVTRCFRDHFFD-RGYYEVTPPTLVQTQVEGGATLFKLDYFG 215 Query: 233 PGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQT 291 F L QS Q + + + L F +A+ YR E SR R E+T ++ E F+ Sbjct: 216 EEAF--LTQSSQLYLETCLP-ALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFD 272 Query: 292 GIQSLIEGLL 301 + + +E L+ Sbjct: 273 DLLNRLEDLV 282 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 9/104 (8%) Query: 509 PSDIHLLYTE--PKKAR-SQHYDLVL-NGNEIGGGSIRIHNAELQRYILATLLKEDVKML 564 P +I Y + P+ +R ++ D+++ N EI GGS+RI ++E ILA +E + Sbjct: 365 PVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSE---EILAGYKREGIDPT 421 Query: 565 SHLL--QALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 + YG PHGG LGL+R + + IRDV +P+ Sbjct: 422 PYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPR 465 >4YCV-A nrPDB Length = 516 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 46/160 (28%), Positives = 84/160 (52%), Gaps = 7/160 (4%) Query: 133 KMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRS 191 K GE+ I K LL+AC + +K +K TE +R + RYLDL + ++ R+ Sbjct: 123 KSKKGELSIFPKETILLSACLHM-LPMKYGLKDTE-IRYRQRYLDLLINESSRHTFVTRT 180 Query: 192 QMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQL 249 +++ +R +L N GF ++ETP + GGA + F+ + L + + ++ Sbjct: 181 KIINFLRNFL-NERGFFEVETP-MMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKM 238 Query: 250 LMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVD 289 L+VGG+D+ +++ + +R+EG PEFT + ++ D Sbjct: 239 LIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYAD 278 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 21/47 (44%), Positives = 30/47 (63%) Query: 559 EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 E ++ S +L+YG PP GG+ LG+DR+ +T SI+DVI FP Sbjct: 456 EAAQLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFP 502 >6AQH-A nrPDB Length = 508 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 111/254 (43%), Gaps = 25/254 (9%) Query: 48 VVRTNTCGELRSSH--------LGQEVTLCGWIQYRRQN---TFLVLRDFDGL-VQVIIP 95 V RT+T E+R ++ G+ V + G + + R + F L++ DG +Q +I Sbjct: 45 VPRTHTLLEIRQAYPDLPVDARTGEIVGVTGRVVFARNSGKLCFATLQEGDGTQLQAMIS 104 Query: 96 QDE-SAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKK 154 E ++ + +V V G VI+ G+ + + ++ K A + Sbjct: 105 LAEVGQEALDNWKTYVDIGDIVFVHGEVITSKRGELSVLADSWQMAAK--------ALRP 156 Query: 155 LPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPT 214 LP K +E R++ RY+DL + + VM+ GF+++ETP Sbjct: 157 LPVAHKEM---SEESRVRQRYVDLIVRDQARKVARQRIAVMRAIRSALERRGFLEVETPM 213 Query: 215 LFKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPD 273 L G A + F+ S L +P+ F + +VGG +R F++ R +R+EG+ Sbjct: 214 LQTLAGGAAARPFVTHSNALDTELYLRIAPELFLKRCLVGGFERVFELNRVFRNEGADST 273 Query: 274 RQPEFTQIDIEMSF 287 PEF ++ ++ Sbjct: 274 HSPEFVMLETYQAY 287 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/39 (48%), Positives = 26/39 (66%), Gaps = 1/39 (2%) Query: 567 LLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 L AL+YG PP G +G+DRL+ +TG SIR+ + FP Sbjct: 466 FLAALEYGMPPSTGTGMGIDRLMMTLTGL-SIRETVLFP 503 >5GRO-A nrPDB Length = 115 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 37/96 (38%), Positives = 54/96 (56%), Gaps = 6/96 (6%) Query: 49 VRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKK 105 +R++ C E+ +G+ V + GW R + F+ LRD GLVQ++ D S+ + +K Sbjct: 12 MRSHFCTEISEKDVGKIVKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVC--DPSSKAYEK 69 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEI 141 L E E V+ G V R AG ENPK+ TG+IEI Sbjct: 70 AL-EVRSEFVLVAKGKVRLRGAGLENPKLKTGKIEI 104 >5ZG8-A nrPDB Length = 438 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/250 (24%), Positives = 111/250 (44%), Gaps = 17/250 (6%) Query: 59 SSHLGQEVTLCGWIQYRRQNT---FLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 + H+ QEV L GW+ RR FL+LRD G +Q + Q E +V + P E+ Sbjct: 9 ARHVDQEVELRGWLYQRRSKGKIHFLILRDGTGFLQATVVQGEVPEAVFREADHLPQETA 68 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFVKKTEALRLQYR 174 ++V G V +E+ + P G E+ V+ ++++ + + P K + + +R Sbjct: 69 LRVWGRV------REDRRAPGG-FELAVRDLQVVSRPQGEYPIGPK---EHGIDFLMDHR 118 Query: 175 YLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPG 234 +L LR + +R+R ++ + E+ GF+ + P L G E G Sbjct: 119 HLWLRHRRPFAVMRIRDELERAIHEFFGE-RGFLRFDAPILTPSAVEGTTELFEVELFDG 177 Query: 235 KFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQTGI 293 + L QS Q + + + + + +R E S+ R EF ++ E++F+ Sbjct: 178 EKAYLSQSGQLYAEAGAL-AFAKVYTFGPTFRAERSKTRRHLLEFWMVEPEVAFMTHEEN 236 Query: 294 QSLIEGLLQY 303 +L E L+ + Sbjct: 237 MALQEELVSF 246 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 39/114 (34%), Positives = 56/114 (49%), Gaps = 14/114 (12%) Query: 504 FTAPHPSDIHLLYTEPKKARSQHYDLVLNGN--------EIGGGSIRIHNAEL-QRYILA 554 F +P+ I Y EP + +LVLN + EI GGS RIH+ EL +R I Sbjct: 325 FVERYPARIKAFYMEPD---PEDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQE 381 Query: 555 TLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 L E+V L +G+ PH G LGL+R + + G +R+ I FP+ + Sbjct: 382 FGLPEEV--YDWYLDLRRFGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRMY 433 >2XGT-A nrPDB Length = 435 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 84/328 (25%), Positives = 135/328 (41%), Gaps = 40/328 (12%) Query: 61 HLGQEVTLCGWI-QYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVV 116 H + V + GWI + RRQ F +LRD G +QV++ D+ + + E V Sbjct: 9 HRNERVCIKGWIHRMRRQGKSLMFFILRDGTGFLQVLL-MDKLCQTYDALTVNT--ECTV 65 Query: 117 QVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEAL--RLQYR 174 ++ G + P G+E P G I + NA P I N + + ++ L R Sbjct: 66 EIYGAIKEVPEGKE---APNGHELIADFWKIIGNA---PPGGIDNVLNEEASVDKMLDNR 119 Query: 175 YLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSREP 233 +L +R LRLR+ MRE+ N G+V++ PTL + + GG+ F + Sbjct: 120 HLVIRGENAAALLRLRAAATRAMREHFYNA-GYVEVAPPTLVQTQVEGGSTLFNLDYFGE 178 Query: 234 GKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQTG 292 F L QS Q + + + L F +A+ YR E SR R E+ ++ E F+ Sbjct: 179 QSF--LTQSSQLYLETC-IPTLGDVFCIAQSYRAEKSRTRRHLAEYAHVEAECPFITLDD 235 Query: 293 IQSLIE-----------------GLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDT 335 + IE LL++ P + P PF M + + + + Sbjct: 236 LMEKIEELVCDTVDRLLADEEAKKLLEHINPKFQPP-ERPFLRMEYKDAIKWLQEHNVEN 294 Query: 336 RFGMKIIDISDVFRNTEIGFLQDALSKP 363 FG D+ E F+ D ++KP Sbjct: 295 EFGNTFTYGEDIAEAAE-RFMTDTINKP 321 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 5/102 (4%) Query: 509 PSDIHLLYTE---PKKARSQHYDLVLNG-NEIGGGSIRIHNAELQRYILATLLKEDVKML 564 PS+I Y + ++ DL++ G EI GGS+RI + + + Sbjct: 328 PSEIKAFYMQRDAQDNTLTESVDLLMPGVGEIVGGSMRIWKFDELSKAFKNVEIDPKPYY 387 Query: 565 SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 +L Q L YG PHGG LGL+R IC +T + IRDV +P+ Sbjct: 388 WYLDQRL-YGTCPHGGYGLGLERFICWLTNTNHIRDVCLYPR 428 >3G1Z-A nrPDB Length = 326 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 21/39 (53%), Positives = 27/39 (69%) Query: 566 HLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAF 604 +LL AL G P G+ALG+DRL+ L G+ S+ DVIAF Sbjct: 283 NLLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAF 321 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 55/123 (44%), Gaps = 7/123 (5%) Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG------AKEFLVPSREPGKFYSL 239 NL R+ ++ ++R + + G +++ETP + + T F+ P G L Sbjct: 16 NLLKRAAIMAEIRRFFAD-RGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGINLYL 74 Query: 240 PQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEG 299 SP+ + L+ G FQ+ R +R+E PEFT ++ D + + ++ Sbjct: 75 MTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNEVDD 134 Query: 300 LLQ 302 LLQ Sbjct: 135 LLQ 137 >3A5Z-A nrPDB Length = 328 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 7/123 (5%) Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG------AKEFLVPSREPGKFYSL 239 NL R+ ++ ++R + + G +++ETP + + T F+ P G L Sbjct: 18 NLLKRAAIMAEIRRFFAD-RGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWL 76 Query: 240 PQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEG 299 SP+ + L+V G FQ+ R +R+E PEFT ++ D + + ++ Sbjct: 77 MTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDD 136 Query: 300 LLQ 302 LLQ Sbjct: 137 LLQ 139 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 18/39 (46%), Positives = 28/39 (71%) Query: 566 HLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAF 604 +L++AL G P G+ALG+DRL+ L G+ ++ +VIAF Sbjct: 285 NLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAF 323 >1NNH-A nrPDB Length = 294 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 14/133 (10%) Query: 247 KQLLMVGGLDRYFQVARCYRDEGSRPD---RQPEFTQIDIEMSFVDQTGIQSLIE----G 299 KQL + GL + F ++ R E + D EFTQ+D E+ I LIE G Sbjct: 80 KQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVERAKMEDIMRLIERLVYG 139 Query: 300 LLQYS--WPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK---IIDISDVFRNTEI- 353 L + + W + P F ++EVL +G+D+ ++ + II+I F + E+ Sbjct: 140 LFRKAEEWTGREFPKTKRFEVFEYSEVLEEFGSDEKASQEMEEPFWIINIPREFYDREVD 199 Query: 354 GFLQDA-LSKPHG 365 GF ++ L P+G Sbjct: 200 GFWRNYDLILPYG 212 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 4/85 (4%) Query: 525 QHYDLVL---NGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGI 581 ++YDL+L G GG ++ I L ED +L A P G Sbjct: 203 RNYDLILPYGYGEVASGGEREWEYEKIVAKIRKAGLNED-SFRPYLEIAKAGKLKPSAGA 261 Query: 582 ALGLDRLICLVTGSPSIRDVIAFPK 606 +G++RL+ + G+ I +V FP+ Sbjct: 262 GIGVERLVRFIVGAKHIAEVQPFPR 286 >3P8T-A nrPDB Length = 294 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 9/95 (9%) Query: 247 KQLLMVGGLDRYFQVARCYRDEGSRPD---RQPEFTQIDIEMSFVDQTGIQSLIEGLL-- 301 KQL + GL++ F ++ R E R D EFTQ+D E+ + LIE L+ Sbjct: 80 KQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIEGAKMKDVMRLIEELIYG 139 Query: 302 ----QYSWPNDKDPVVVPFPTMTFAEVLATYGTDK 332 W + P F + ++L +G+D+ Sbjct: 140 LFRKAEEWTGREFPRARHFKVYDYKDILEEFGSDE 174 Score = 33.9 bits (76), Expect = 0.24, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 4/95 (4%) Query: 515 LYTEPKKARSQHYDLVL---NGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQAL 571 Y + ++YDL+L G GG ++ I A LKED +L A Sbjct: 193 FYDREENGVWKNYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKED-SFRPYLEIAR 251 Query: 572 DYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 P G +G++RL+ + G+ I +V FP+ Sbjct: 252 AGKLKPSAGAGIGVERLVRFIVGAKHIAEVQPFPR 286 >5EJY-A nrPDB Length = 500 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 30/140 (21%), Positives = 60/140 (42%), Gaps = 22/140 (15%) Query: 2 YFPSWLSQLYR--GLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSS----------FVV 49 YF ++L + +S+ ++ + Q + L R L +++++P + FV Sbjct: 145 YFAAYLKTTIQQSDVSKSVKDSAQASYFILQRFTLNGARKQVPSVTELESIKENRPIFVR 204 Query: 50 RTNTCGELRSSHLGQEVT-------LCGWIQYR---RQNTFLVLRDFDGLVQVIIPQDES 99 T T G L+ H+ T L + R ++N F ++ F+G+ + I P D+ Sbjct: 205 ITATDGSLKGLHIDSATTCQESSNDLSQRSRMRVNSKENGFTIIESFNGIERDIAPTDKL 264 Query: 100 AASVKKILCEAPVESVVQVS 119 + K+ S +QV+ Sbjct: 265 CDVLSKVENLQATLSSIQVN 284 >1ZN9-A nrPDB Length = 180 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/32 (50%), Positives = 20/32 (62%), Gaps = 3/32 (9%) Query: 436 DVVLLTAGEHNKACSLLGKLR---LECADLLE 464 D +L T G N AC LLG+L+ LEC L+E Sbjct: 127 DDLLATGGTMNAACELLGRLQAEVLECVSLVE 158 >5LL6-h nrPDB Length = 608 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 32/68 (47%), Gaps = 13/68 (19%) Query: 542 RIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDV 601 R++ A++ R +LA + V + H L LDY L +C++ G PS+ V Sbjct: 257 RLNAAQIIRSLLAP--TKYVICVEHDLSVLDY-----------LSDFVCIIYGVPSVYGV 303 Query: 602 IAFPKSFR 609 + P S R Sbjct: 304 VTLPASVR 311 >5X0Z-E nrPDB Length = 197 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 11/120 (9%) Query: 204 LHGFVDIETPTLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVAR 263 + V+I+ ++ + T G EFL+ P F P +L + + + R Sbjct: 35 MRSIVEIQLHSVDQMTYG---EFLMSLPSPTSFNVFSMKPMGGTGVLEINPSIAFPMIDR 91 Query: 264 CYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAE 323 +GS D+ EF+ DIE++ +D T ++ +++ +L+ W PVV FPT+ E Sbjct: 92 LLGGKGSAYDQNREFS--DIELNLLD-TILRQVMQ-ILKEVW----SPVVEMFPTIDAKE 143 >6HIV-DP nrPDB Length = 274 Score = 29.6 bits (65), Expect = 3.9, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 22/43 (51%) Query: 1 MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPE 43 M + +WL L R +RP QP+W S R +L+ + PE Sbjct: 45 MLYQAWLGGLDRPYTRPKCMANQPLWLSKKRHMLRKERLDGPE 87 >6EHO-A nrPDB Length = 723 Score = 28.5 bits (62), Expect = 9.8, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 26/59 (44%), Gaps = 2/59 (3%) Query: 297 IEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDK--PDTRFGMKIIDISDVFRNTEI 353 + G + SW D V++ T V+ T+G K +G DI+D+ NT I Sbjct: 75 LRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFI 133 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4AH6-A nrPDB 847 0.0 4RMF-A nrPDB 719 0.0 1IL2-A nrPDB 713 0.0 5W25-A nrPDB 701 0.0 4WJ3-M nrPDB 698 0.0 1EFW-A nrPDB 612 e-175 4UP8-A nrPDB 315 3e-86 3A74-A nrPDB 307 8e-84 4EX5-A nrPDB 283 2e-76 3NEM-A nrPDB 276 3e-74 1BBU-A nrPDB 275 4e-74 1LYL-A nrPDB 272 3e-73 1WYD-A nrPDB 266 2e-71 5XIX-A nrPDB 256 2e-68 1X54-A nrPDB 256 2e-68 2XGT-A nrPDB 252 3e-67 6AQG-A nrPDB 244 1e-64 6AQH-A nrPDB 241 1e-63 3M4P-A nrPDB 233 2e-61 6NRZ-A nrPDB 233 3e-61 4J15-A nrPDB 232 4e-61 5HGQ-A nrPDB 230 1e-60 6CHD-A nrPDB 228 4e-60 6ILH-A nrPDB 226 2e-59 6OD8-A nrPDB 224 1e-58 5ELO-A nrPDB 219 3e-57 1ASZ-A nrPDB 219 4e-57 1N9W-A nrPDB 210 1e-54 5ZG8-A nrPDB 210 1e-54 4YCV-A nrPDB 200 2e-51 3I7F-A nrPDB 195 5e-50 3G1Z-A nrPDB 139 3e-33 3A5Z-A nrPDB 132 6e-31 5GRO-A nrPDB 101 1e-21 Sequences not found previously or not previously below threshold: 3P8T-A nrPDB 79 8e-15 1NNH-A nrPDB 75 9e-14 3VQX-A nrPDB 55 8e-08 2ZNJ-A nrPDB 52 1e-06 6JP2-A nrPDB 45 8e-05 11AS-A nrPDB 41 0.002 2D6F-C nrPDB 37 0.021 3L4G-A nrPDB 37 0.022 3M8U-A nrPDB 36 0.051 5AYL-A nrPDB 35 0.089 5E3I-A nrPDB 35 0.092 1IYW-A nrPDB 35 0.11 4LNS-A nrPDB 35 0.13 6NCZ-A nrPDB 35 0.13 1ZQ1-C nrPDB 34 0.19 2Y8V-A nrPDB 33 0.41 6HIV-DP nrPDB 33 0.43 5MEK-A nrPDB 32 0.62 2DU4-A nrPDB 32 0.91 6DXS-A nrPDB 32 1.0 4JH6-A nrPDB 31 1.5 3TUP-A nrPDB 31 2.0 6F8L-G nrPDB 30 2.1 1O5Q-A nrPDB 30 2.7 2NUX-A nrPDB 30 3.3 2ALY-A nrPDB 30 3.3 5AXK-A nrPDB 30 3.4 1PYS-A nrPDB 30 3.9 3QN3-A nrPDB 29 5.6 >4AH6-A nrPDB Length = 617 Score = 847 bits (2188), Expect = 0.0, Method: Composition-based stats. Identities = 605/605 (100%), Positives = 605/605 (100%) Query: 41 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA 100 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA Sbjct: 2 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQNTFLVLRDFDGLVQVIIPQDESA 61 Query: 101 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK 160 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK Sbjct: 62 ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIK 121 Query: 161 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP 220 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP Sbjct: 122 NFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP 181 Query: 221 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ 280 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ Sbjct: 182 GGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQ 241 Query: 281 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK 340 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK Sbjct: 242 IDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMK 301 Query: 341 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL 400 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL Sbjct: 302 IIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEIL 361 Query: 401 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 460 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA Sbjct: 362 PVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 421 Query: 461 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 520 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK Sbjct: 422 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 481 Query: 521 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG 580 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG Sbjct: 482 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGG 541 Query: 581 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK 640 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK Sbjct: 542 IALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSK 601 Query: 641 AERAH 645 AERAH Sbjct: 602 AERAH 606 >4RMF-A nrPDB Length = 609 Score = 719 bits (1857), Expect = 0.0, Method: Composition-based stats. Identities = 241/609 (39%), Positives = 350/609 (57%), Gaps = 36/609 (5%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVK 104 ++RT+ G LR + GQ VTL GW+ RR + F+ LRD G+ QV+ + + A+ Sbjct: 1 MLRTHAAGSLRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGDVLAAAH 60 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 ++ E V V+G V RP G ENP++PTG+IE+ +L LPF++ + Sbjct: 61 RLRA----EFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESAPLPFQLDE--Q 114 Query: 165 KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAK 224 E RL+YRYLDLR LRLRS++ R L H FV+IETPTL + TP GA+ Sbjct: 115 AGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAE-HDFVEIETPTLTRSTPEGAR 173 Query: 225 EFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 283 +FLVP+R +PG FY+LPQSPQ FKQLLMV G++RY+Q+ARCYRDE R DRQPEFTQ+D+ Sbjct: 174 DFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDM 233 Query: 284 EMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIID 343 EMSFV+ + ++ E +L+ W + +P P +++ E + +G+DKPD RFG+++++ Sbjct: 234 EMSFVEADDVIAISEQVLKAVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRFGIELVE 293 Query: 344 ISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVF 403 ++ F++T Q P+ V A+ +P GA R+ ++ + FA ++ + V Sbjct: 294 CTEYFKDTTFRVFQ----APY--VGAVVMPGGASQ-PRRTLDGWQEFAKQRGHKGLAYVL 346 Query: 404 LNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLL 463 + + PVA + +++R L+ + D + AG A +LLG R+E A L Sbjct: 347 VGEDGTLGGPVAKNLSDAERDGLVAHVGANPGDCIFFAAGPAKGARALLGATRIEIAKRL 406 Query: 464 ETRGVVLRDPTLFSFLWVVDFPLFLPKEENP---------RELESAHHPFTAPHPSDIHL 514 + L DP ++F WVVDFP+F +E + HH FTAP P + Sbjct: 407 D-----LIDPNAWAFTWVVDFPMFEAADEATAAGDVAVGSGAWTAMHHAFTAPKPDSVDT 461 Query: 515 LYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQAL 571 ++P A S YD+V NGNEIGGGSIRIH ++Q + A + E + LL A Sbjct: 462 FDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFLLDAF 521 Query: 572 DYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHI 631 YGAPPHGGIA G DR+ L+ G SIR+VIAFPKS G D +++ P + P++ K I Sbjct: 522 SYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDPLTDAPAPITPQQRKESGI 581 Query: 632 RVSKPTDSK 640 +KP + K Sbjct: 582 D-AKPREDK 589 >1IL2-A nrPDB Length = 590 Score = 713 bits (1841), Expect = 0.0, Method: Composition-based stats. Identities = 241/602 (40%), Positives = 347/602 (57%), Gaps = 24/602 (3%) Query: 49 VRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKK 105 +RT CG+LR SH+GQ+VTLCGW+ RR F+ +RD +G+VQV D A K Sbjct: 1 MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFDPDR--ADALK 58 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKK 165 + E E +QV+GTV +R N M TGEIE+ + ++N LP + + Sbjct: 59 LASELRNEFCIQVTGTVRARDEKNINRDMATGEIEVLASSLTIINRADVLPLDSNHV--N 116 Query: 166 TEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKE 225 TE RL+YRYLDLR +M L+ R+++ +R ++ + HGF+DIETP L K TP GA++ Sbjct: 117 TEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDD-HGFLDIETPMLTKATPEGARD 175 Query: 226 FLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIE 284 +LVPSR GKFY+LPQSPQ FKQLLM+ G DRY+Q+ +C+RDE R DRQPEFTQID+E Sbjct: 176 YLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVE 235 Query: 285 MSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDI 344 SF+ ++ ++E L+++ W K + FP MTFAE YG+DKPD R M++ D+ Sbjct: 236 TSFMTAPQVREVMEALVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDV 295 Query: 345 SDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFL 404 +D+ ++ E + P G V A+ +P GA L RK I+ NF + + + + + Sbjct: 296 ADLLKSVEFAVFAGPANDPKGRVAALRVPGGAS-LTRKQIDEYGNFVKIYGAKGLAYIKV 354 Query: 405 NAN----RNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECA 460 N NSPVA F+ +++ Q+ D++ A +G LRL+ Sbjct: 355 NERAKGLEGINSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKKIVADAMGALRLKVG 414 Query: 461 DLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPK 520 L L D + ++ LWV+DFP+F +++ L + HHPFT+P L P+ Sbjct: 415 KDLG-----LTDESKWAPLWVIDFPMF--EDDGEGGLTAMHHPFTSPKDMTAAELKAAPE 467 Query: 521 KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQALDYGAPP 577 A + YD+V+NG E+GGGS+RIHN ++Q+ + L +E + LL AL YG PP Sbjct: 468 NAVANAYDMVINGYEVGGGSVRIHNGDMQQTVFGILGINEEEQREKFGFLLDALKYGTPP 527 Query: 578 HGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPT 637 H G+A GLDRL L+TG+ +IRDVIAFPK+ LM+ P P L I+V K Sbjct: 528 HAGLAFGLDRLTMLLTGTDNIRDVIAFPKTTAAACLMTEAPSFANPTALAELSIQVVKKA 587 Query: 638 DS 639 ++ Sbjct: 588 EN 589 >5W25-A nrPDB Length = 616 Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats. Identities = 239/611 (39%), Positives = 342/611 (55%), Gaps = 32/611 (5%) Query: 47 FVVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASV 103 FV+R++ G LR GQ+VTL GW+ RR + F+ LRD G+ QV+ +D V Sbjct: 22 FVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVF-RDPQDTEV 80 Query: 104 KKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFV 163 E V V+G V RP G NP++ TGEIE+ + +L C LPF++ Sbjct: 81 LAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATSLTVLGECAPLPFQLDEP- 139 Query: 164 KKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA 223 E LRL+YRYLDLR +RLRS++ R L H FV+IETPT+ + TP GA Sbjct: 140 -AGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLA-RHDFVEIETPTITRSTPEGA 197 Query: 224 KEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQID 282 ++FLVP+R PG FY+LPQSPQ FKQLLMV G++RY+Q+ARCYRDE R DRQPEFTQ+D Sbjct: 198 RDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLD 257 Query: 283 IEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKII 342 +EMSFVD I ++ E +L W + P P + +AE + +GTDKPD RFG++++ Sbjct: 258 MEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRFGLELV 317 Query: 343 DISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPV 402 + +D F +T Q P+ V A+ +P GA R+ ++ +++A ++ + V Sbjct: 318 ECTDFFSDTTFRVFQ----APY--VGAVVMPGGASQ-PRRTLDGWQDWAKQRGHRGLAYV 370 Query: 403 FLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADL 462 + + PVA + E++R L + + D + +AG + +LLG R+E A+ Sbjct: 371 LVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAARVEIANR 430 Query: 463 LETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESA---------HHPFTAPHPSDIH 513 L L DP ++F+WVVD PLF P +E E A HH FTAP P Sbjct: 431 LG-----LIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWTAVHHAFTAPKPEWED 485 Query: 514 LLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQA 570 + ++ + YD+V NG+EIGGGS+RIH ++Q + A + E + LL+A Sbjct: 486 RIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEA 545 Query: 571 LDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYH 630 +GAPPHGGIA G DR L+ G SIR+VIAFPK+ G D +++ P + ++ K Sbjct: 546 FMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDPLTDAPAPITAQQRKESG 605 Query: 631 IRVSKPTDSKA 641 I +A Sbjct: 606 IDAQPKRVQQA 616 >4WJ3-M nrPDB Length = 599 Score = 698 bits (1802), Expect = 0.0, Method: Composition-based stats. Identities = 241/606 (39%), Positives = 352/606 (58%), Gaps = 26/606 (4%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVK 104 ++R++ CG+L S GQEVTLCGW+ RR + FL +RD +GL QV+ D A Sbjct: 9 MMRSHYCGQLNESLDGQEVTLCGWVHRRRDHGGVIFLDVRDREGLAQVVFDPDR--AETF 66 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 E VV+++G V RP G NP M +G IE+ E+LN + PF + + Sbjct: 67 AKADRVRSEFVVKITGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSD 126 Query: 165 KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAK 224 E RL+YR++DLR +M L+LR+++ +R YL + +GF+D+ETP L + TP GA+ Sbjct: 127 VGEETRLRYRFIDLRRPEMAAKLKLRARITSSIRRYLDD-NGFLDVETPILGRPTPEGAR 185 Query: 225 EFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 283 ++LVPSR PG F++LPQSPQ FKQLLMV G DRY+Q+A+C+RDE R DRQPEFTQIDI Sbjct: 186 DYLVPSRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDI 245 Query: 284 EMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIID 343 E SF+D++ I + E +++ + D FP M F E + YG+DKPD R ++++D Sbjct: 246 ETSFLDESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVD 305 Query: 344 ISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVF 403 ++D + E + P G V A+ +P GA + R I+ F + + + + Sbjct: 306 VADQLKEVEFKVFSGPANDPKGRVAALRVP-GAASMPRSQIDDYTKFVGIYGAKGLAYIK 364 Query: 404 LNAN----RNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLEC 459 +N SP+ FI E+ ++ + + D+V A + C LG LR++ Sbjct: 365 VNERAKGVEGLQSPIVKFIPEANLNVILDRVGAVDGDIVFFGADKAKIVCDALGALRIKV 424 Query: 460 ADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEP 519 L+ ++ R+ ++ +WVVDFP+F +E + L + HHPFT+P + L P Sbjct: 425 GHDLK---LLTRE---WAPMWVVDFPMF--EENDDGSLSALHHPFTSPKCTPAE-LEANP 475 Query: 520 KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATL---LKEDVKMLSHLLQALDYGAP 576 A S+ YD+VLNG E+GGGSIRIH+ +Q+ + L E + LL AL YGAP Sbjct: 476 GAALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLLDALKYGAP 535 Query: 577 PHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKP 636 PHGG+A GLDRL+ L+TG+ SIR+VIAFPK+ D+M+ P SV + L+ HIR+ Sbjct: 536 PHGGLAFGLDRLVMLMTGASSIREVIAFPKTQSAGDVMTQAPGSVDGKALRELHIRL--R 593 Query: 637 TDSKAE 642 KAE Sbjct: 594 EQPKAE 599 >1EFW-A nrPDB Length = 580 Score = 612 bits (1578), Expect = e-175, Method: Composition-based stats. Identities = 258/603 (42%), Positives = 358/603 (59%), Gaps = 37/603 (6%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVK 104 + RT+ G LR +H+G+EV L GW+ RR FL LRD +GLVQ++ A+ Sbjct: 1 MRRTHYAGSLRETHVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVAHP---ASPAY 57 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 E VV+ G V RP NP++ TG +E+++ E+L K PF + + Sbjct: 58 ATAERVRPEWVVRAKGLVRLRPEP--NPRLATGRVEVELSALEVLAEAKTPPFPVDAGWR 115 Query: 165 ------KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR 218 +E LRL+YRYLDLR +MQ NLRLR +++ + ++L + GFV +ETP L K Sbjct: 116 GEEEKEASEELRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFL-DREGFVQVETPFLTKS 174 Query: 219 TPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPE 277 TP GA++FLVP R EPG FY+LPQSPQ FKQ+LMV GLDRYFQ+ARC+RDE R DRQP+ Sbjct: 175 TPEGARDFLVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPD 234 Query: 278 FTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKD-PVVVPFPTMTFAEVLATYGTDKPDTR 336 FTQ+D+EMSFV+ + L E L+ + + + +PFP +++ E + YG+DKPD R Sbjct: 235 FTQLDLEMSFVEVEDVLELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLR 294 Query: 337 FGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFN 396 FG+++ ++ +FR + Q+A S VKA+ +P K L RK++ + A H Sbjct: 295 FGLELKEVGPLFRQSGFRVFQEAES-----VKALALP---KALSRKEVAELEEVAKRHKA 346 Query: 397 QEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLR 456 Q + + ++ VA F+ E R L++ E + D +L AG A + LG +R Sbjct: 347 QGLAWARVEE-GGFSGGVAKFL-EPVREALLQATEARPGDTLLFVAGPRKVAATALGAVR 404 Query: 457 LECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLY 516 L ADLL + F FLWVVDFPL L +E HHPFT+PHP D+ LL Sbjct: 405 LRAADLLGLKREG------FRFLWVVDFPL-LEWDEEEEAWTYMHHPFTSPHPEDLPLLE 457 Query: 517 TEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILA---TLLKEDVKMLSHLLQALDY 573 +P + R+ YDLVLNG E+GGGSIRIH+ LQ + +E + L+AL+Y Sbjct: 458 KDPGRVRALAYDLVLNGVEVGGGSIRIHDPRLQARVFRLLGIGEEEQREKFGFFLEALEY 517 Query: 574 GAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRV 633 GAPPHGGIA GLDRL+ L+TGSPSIR+VIAFPK+ G D ++ P VP E+L+ + V Sbjct: 518 GAPPHGGIAWGLDRLLALMTGSPSIREVIAFPKNKEGKDPLTGAPSPVPEEQLRELGLMV 577 Query: 634 SKP 636 +P Sbjct: 578 VRP 580 >4UP8-A nrPDB Length = 777 Score = 315 bits (808), Expect = 3e-86, Method: Composition-based stats. Identities = 114/588 (19%), Positives = 232/588 (39%), Gaps = 81/588 (13%) Query: 41 IPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRRQN----TFLVLRDFDGLVQVIIPQ 96 +PEF + G +S V++ G + +R + F+ L D +Q+++ + Sbjct: 42 VPEFIA-----KYSGLEKSQVSDDIVSVAGRVLSKRSSSSALMFIDLHDSQTKLQIMLNK 96 Query: 97 D--ESAASVKKILCEAPVESVVQVSGTVISRPAGQENP-KMPTGEIEIKVKTAELLNACK 153 E+ + + +G +P + TGE+ + + +L+ C Sbjct: 97 SAYENKEDFVSLTKMIYRGDICGFTG----------HPTRTKTGELSLIPISGMILSPCL 146 Query: 154 KLPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIET 212 + ++ + R + RYLDL + + N LR+++V +R+YL + GF+++ET Sbjct: 147 HM-LPSMHYGLGDQETRFRKRYLDLIVNPESVKNFVLRTKVVKAVRKYLDD-KGFLEVET 204 Query: 213 PTLFKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGS 270 P L PGGA + F+ + + +P+ + + L+VGG++R +++ R +R+EG Sbjct: 205 PIL-NTIPGGATARPFITHHNQLDIQMYMRIAPELYLKELVVGGINRVYEIGRLFRNEGI 263 Query: 271 RPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGT 330 PEFT + M++ D I + E LL + G+ Sbjct: 264 DQTHNPEFTTCEFYMAYADYNDIMKMTEELLGNMVKDITG------------------GS 305 Query: 331 DKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNF 390 K + + + I+ + + E F ++ + +P + + + E ++ + Sbjct: 306 TKLEIKDRLMDINNEEDIKMLE-KFFKEPIPRPFNSAECSKVIEKHCT----ELNYYYDG 360 Query: 391 AADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACS 450 + +++ F+ + V +F +R+ + +E + + Sbjct: 361 NNEKAMKKLFADFVTEKKM----VLDFTAPFKRISYVHALEEKFGE---------KIPRP 407 Query: 451 LLGKLRLECADLLETR-GVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHP 509 L G L R + +P + V+D LF + E++ F P Sbjct: 408 LDGPEALTFLKKQAIRFNAICAEPQTTAR--VMD-KLFG----DLIEVDLVQPTFVCDQP 460 Query: 510 SDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSH- 566 + L Y + ++ ++L + EI ++N +QR K+ Sbjct: 461 QLMSPLAKYHRSEPELTERFELFILKREIANAYTELNNPIVQRSNFEQQAKDKAAGDDEA 520 Query: 567 ------LLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 L A+++ PP GG LG+DRL L+ +I++VI FP Sbjct: 521 QLVDEVFLDAIEHAFPPTGGWGLGIDRLAMLLADVDNIKEVILFPTMR 568 >3A74-A nrPDB Length = 493 Score = 307 bits (787), Expect = 8e-84, Method: Composition-based stats. Identities = 125/574 (21%), Positives = 215/574 (37%), Gaps = 130/574 (22%) Query: 50 RTNTCGELRSSHLG----------QEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQ 96 RT+ EL + EV + G I +R + F ++D G +Q+ + Q Sbjct: 33 RTHKAEELFELYGDLSKEELEEQQIEVAVAGRIMTKRGMGKAGFAHIQDVTGQIQIYVRQ 92 Query: 97 DESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLP 156 D+ ++ + + +V V GT+ K GE+ IKV + E L + P Sbjct: 93 DDVGEQQYELFKISDLGDIVGVRGTMF---------KTKVGELSIKVSSYEFLTKALR-P 142 Query: 157 FEIKNFVKKTEALRLQYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTL 215 K K R + RYLDL + + + RS ++ MR YL + HG++++ETP + Sbjct: 143 LPEKYHGLKDIEQRYRQRYLDLIMNPESKKTFITRSLIIQSMRRYL-DSHGYLEVETPMM 201 Query: 216 FKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDR 274 G A + F+ + + + + L+VGGL++ +++ R +R+EG Sbjct: 202 HAVAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGISTRH 261 Query: 275 QPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPD 334 PEFT +++ ++ D I L E L+ + GT K Sbjct: 262 NPEFTMLELYEAYADFRDIMKLTENLIAHI-------------------ATEVLGTTK-- 300 Query: 335 TRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADH 394 ++G ++D++ +R + V AI G + ++ E R A +H Sbjct: 301 IQYGEHLVDLTPEWRRLHM-------------VDAIKEYVGVDFWRQMSDEEARELAKEH 347 Query: 395 FNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGK 454 V + + + V F + +LI+ Sbjct: 348 G------VEVAPHMTFGHIVNEFFEQKVEDKLIQPT------------------------ 377 Query: 455 LRLECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHL 514 +E + ++P F F LF+ E+ + P Sbjct: 378 --FIYGHPVEISPLAKKNPDDPRFT--DRFELFIVGREHANAFTELNDPIDQR------- 426 Query: 515 LYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYG 574 Q ++ L E G E +M L+AL+YG Sbjct: 427 ----------QRFEEQLKEREQGN-------------------DEAHEMDEDFLEALEYG 457 Query: 575 APPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 PP GG+ +G+DRL+ L+T SPSIRDV+ FP+ Sbjct: 458 MPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQMR 491 >4EX5-A nrPDB Length = 529 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 143/348 (41%), Gaps = 50/348 (14%) Query: 51 TNTCGELRSSHLGQ----------EVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQD 97 T+ +L++++ EV + G + +R + +F ++D G +Q + Sbjct: 64 THHAADLQTAYADADKEALEAKSLEVAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPA 123 Query: 98 ESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELL-NACKKLP 156 + A + + +V G + + GE+ +K LL A + LP Sbjct: 124 DVGAETYDAFKKWDLGDIVAARGVLF---------RTNKGELSVKCTQLRLLAKALRPLP 174 Query: 157 FEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTL 215 + + R + RY+DL + + + R R++ + +R+++ + F+++ETP L Sbjct: 175 DKFHGL--ADQETRYRQRYVDLIVTPETRTTFRARTKAIASIRKFMGDA-DFMEVETPML 231 Query: 216 FKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDR 274 G A K F+ L +P+ + + L+VGG +R F++ R +R+EG P Sbjct: 232 HPIPGGAAAKPFVTHHNALDMEMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRH 291 Query: 275 QPEFTQIDIEMSFVDQTGIQSLIEGLLQYS-----------WPNDKDPVVVPFPTMTFAE 323 PEFT ++ ++ D + E L++ + + + + PF +T + Sbjct: 292 NPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIQYQGRELDLAQPFHRLTITQ 351 Query: 324 VLATYGTDKPDTRFGMKI----------IDISD-VFRNTEIGFLQDAL 360 + Y D + +D++ F N IG LQ AL Sbjct: 352 AIQKYAPSYTDGQLSDDAFLRSELKRLGVDVTQPAFLNAGIGALQLAL 399 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 9/127 (7%) Query: 492 ENPRELESAHHPFTAPHPSDIHLLYTEPK--KARSQHYDLVLNGNEIGGGSIRIHNAELQ 549 E E + F +P ++ L E ++ ++L + G EI G +++ E Q Sbjct: 401 EETAEAQLWEPTFIIDYPIEVSPLARESDTVAGITERFELFITGREIANGFSELNDPEDQ 460 Query: 550 RYILATL-----LKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVI 602 ++ M + ++AL+YG PP GG +G+DRL+ L+T SP+IRDV+ Sbjct: 461 AARFKKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVL 520 Query: 603 AFPKSFR 609 FP R Sbjct: 521 LFPHLRR 527 >3NEM-A nrPDB Length = 438 Score = 276 bits (705), Expect = 3e-74, Method: Composition-based stats. Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 38/339 (11%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQNT---FLVLRDFDGLVQVIIPQDESAASVK 104 + RT+ E+ GQ+V + GW+ + FL +RD DG+VQ+ P+ + + Sbjct: 1 MYRTHYSSEITEELNGQKVKVAGWVWEVKDLGGIKFLWIRDRDGIVQITAPKKKVDPELF 60 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVK 164 K++ + E VV V G V PK G + K L A LP + VK Sbjct: 61 KLIPKLRSEDVVAVEGVV------NFTPKAKLGFEILPEKIVVLNRAETPLPLDPTGKVK 114 Query: 165 KTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLF-KRTPGGA 223 RL R++DLR ++ ++RS + +R++ +GF++I TP + T GG Sbjct: 115 AELDTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHE-NGFIEIHTPKIIATATEGGT 173 Query: 224 KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQID 282 + F + E F L QSPQ +KQ++M GLDR +++A +R E R E ID Sbjct: 174 ELFPMKYFEEDAF--LAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWSID 231 Query: 283 IEMSFV-DQTGIQSLIEGLLQYSWP-------------NDKDPVV-VPFPTMTFAEVLAT 327 EM+F+ D+ + S +E L+ ++ N + +PFP +++ + L Sbjct: 232 SEMAFIEDEEEVMSFLERLVAHAINYVREHNAKELDILNFELEEPKLPFPRVSYDKALEI 291 Query: 328 YGTDKPDTRFGMKIIDISDVFRNTEI---GFLQDALSKP 363 G G +I D+ E ++ + + P Sbjct: 292 LGD------LGKEIPWGEDIDTEGERLLGKYMMENENAP 324 Score = 130 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 6/122 (4%) Query: 496 ELESAHHPFTAPHPSDIHLLYTEPKKARSQ---HYDLVLNGNEIGGGSIRIHNAELQ-RY 551 E E+A F +PS+ Y + + +DL G EI G R H ++ Sbjct: 319 ENENAPLYFLYQYPSEAKPFYIMKYDNKPEICRAFDLEYRGVEISSGGQREHRHDILVEQ 378 Query: 552 ILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGH 611 I L + L+A YG PPHGG LG +RLI + P+IR+VI FP+ R Sbjct: 379 IKEKGLN--PESFEFYLKAFRYGMPPHGGFGLGAERLIKQMLDLPNIREVILFPRDRRRL 436 Query: 612 DL 613 Sbjct: 437 TP 438 >1BBU-A nrPDB Length = 504 Score = 275 bits (703), Expect = 4e-74, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 144/328 (43%), Gaps = 44/328 (13%) Query: 50 RTNTCGELRSSHLGQE----------VTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQ 96 R +T +L + G+E V + G + RR + +F+ L+D G +Q+ + + Sbjct: 41 RDHTSDQLHAEFDGKENEELEALNIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVAR 100 Query: 97 DESAAS-VKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLN-ACKK 154 D+ + + + ++ G + K TGE+ I LL A + Sbjct: 101 DDLPEGVYNEQFKKWDLGDILGAKGKLF---------KTKTGELSIHCTELRLLTKALRP 151 Query: 155 LPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETP 213 LP + + + R + RYLDL + + + ++RSQ++ +R+++ N GF+++ETP Sbjct: 152 LPDKFHGL--QDQEARYRQRYLDLISNDESRNTFKVRSQILSGIRQFMVN-RGFMEVETP 208 Query: 214 TLFKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSR 271 + + PGGA + F+ L +P+ + + L+VGG +R F++ R +R+EG Sbjct: 209 MM-QVIPGGAAARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGIS 267 Query: 272 PDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVV-----------PFPTMT 320 PEFT +++ M++ D + L E L + + V PF +T Sbjct: 268 VRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDILGKTEVTYGDVTLDFGKPFEKLT 327 Query: 321 FAEVLATYGT--DKPDTRFGMKIIDISD 346 E + Y D D I++ Sbjct: 328 MREAIKKYRPETDMADLDNFDSAKAIAE 355 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 35/126 (27%), Positives = 56/126 (44%), Gaps = 9/126 (7%) Query: 492 ENPRELESAHHPFTAPHPSDIHLLYTEPK--KARSQHYDLVLNGNEIGGGSIRIHNAELQ 549 E E F +P+++ L + ++ + G EIG G +++AE Q Sbjct: 376 EEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQ 435 Query: 550 RYIL-----ATLLKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVI 602 A +D M + AL++G PP G+ +G+DR++ L T S +IRDVI Sbjct: 436 AQRFLDQVAAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVI 495 Query: 603 AFPKSF 608 FP Sbjct: 496 LFPAMR 501 >1LYL-A nrPDB Length = 504 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 142/330 (43%), Gaps = 42/330 (12%) Query: 31 RSLLQSSQRRIPEFSSFVVRTNTCGELRSSHL----------GQEVTLCGWIQYRR---Q 77 R L + +++ F + R +T +L EV++ G + RR + Sbjct: 22 REKLAALRQQGVAFPNDFRRDHTSDQLHEEFDAKDNQELESLNIEVSVAGRMMTRRIMGK 81 Query: 78 NTFLVLRDFDGLVQVIIPQDESAAS-VKKILCEAPVESVVQVSGTVISRPAGQENPKMPT 136 +F+ L+D G +Q+ + +D + + ++ GT+ K T Sbjct: 82 ASFVTLQDVGGRIQLYVARDSLPEGVYNDQFKKWDLGDIIGARGTLF---------KTQT 132 Query: 137 GEIEIKVKTAELLN-ACKKLPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMV 194 GE+ I LL A + LP + + + +R + RYLDL + + + +RS+++ Sbjct: 133 GELSIHCTELRLLTKALRPLPDKFHGL--QDQEVRYRQRYLDLIANDKSRQTFVVRSKIL 190 Query: 195 MKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMV 252 +R+++ GF+++ETP + + PGGA + F+ L +P+ + + L+V Sbjct: 191 AAIRQFMV-ARGFMEVETPMM-QVIPGGASARPFITHHNALDLDMYLRIAPELYLKRLVV 248 Query: 253 GGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKD-- 310 GG +R F++ R +R+EG PEFT +++ M++ D + L E L + Sbjct: 249 GGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYHDLIELTESLFRTLAQEVLGTT 308 Query: 311 ---------PVVVPFPTMTFAEVLATYGTD 331 PF +T E + Y + Sbjct: 309 KVTYGEHVFDFGKPFEKLTMREAIKKYRPE 338 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 9/126 (7%) Query: 492 ENPRELESAHHPFTAPHPSDIHLLYTEPK--KARSQHYDLVLNGNEIGGGSIRIHNAE-- 547 + E F +P+++ L + ++ + G EIG G +++AE Sbjct: 376 DEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQ 435 Query: 548 ---LQRYILATLLKEDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVI 602 Q + A +D M + AL+YG PP G+ +G+DR+I L T S +IRDVI Sbjct: 436 AERFQEQVNAKAAGDDEAMFYDEDYVTALEYGLPPTAGLGIGIDRMIMLFTNSHTIRDVI 495 Query: 603 AFPKSF 608 FP Sbjct: 496 LFPAMR 501 >1WYD-A nrPDB Length = 429 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 95/314 (30%), Positives = 151/314 (48%), Gaps = 34/314 (10%) Query: 48 VVRTNTCGELRSSHLGQEVTLCGWIQYRRQ---NTFLVLRDFDGLVQVIIPQDESAASVK 104 + R++ ++ + G+EV GW+ R F++LRD GL QV++ ++ SA + Sbjct: 1 MYRSHFIADVTPEYDGKEVIWAGWVHLLRDLGGKKFIILRDKTGLGQVVVDKNSSAFGIS 60 Query: 105 KILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFV 163 + L + ESV+QV G V + + + P G IE+ + LL+ K LP ++ V Sbjct: 61 QELTQ---ESVIQVRGIV------KADKRAPRG-IELHAEEITLLSKAKAPLPLDVSGKV 110 Query: 164 KKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGG 222 K RL+ R LDLR +MQ ++++S + RE L GF++I TP + T GG Sbjct: 111 KADIDTRLRERVLDLRRQEMQAVIKIQSLALKAFRETLYK-EGFIEIFTPKIIASATEGG 169 Query: 223 AKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRP-DRQPEFTQI 281 A+ F V GK L QSPQ +K+ LM G ++R F+VA +R E S EF + Sbjct: 170 AQLFPVIYF--GKEAFLAQSPQLYKE-LMAGVVERVFEVAPAWRAEESDTPFHLAEFISM 226 Query: 282 DIEMSFVDQTGIQSLIEGLLQYSWPNDK--------------DPVVVPFPTMTFAEVLAT 327 D+EM+F D + L+E +L K V +P + + E + Sbjct: 227 DVEMAFADYNDVMQLLEKILHNIVKTIKEEGKEELKILNYEPPEVKIPIKRLKYTEAIEI 286 Query: 328 YGTDKPDTRFGMKI 341 + + +FG I Sbjct: 287 LRSKGYNIKFGDDI 300 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 4/115 (3%) Query: 502 HPFTAPHPSDIHLLYTEPK---KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK 558 F PSD YT+ K S+ +DL+ EI GS R H E+ L Sbjct: 316 LYFIVDWPSDARPFYTKSKSENPELSESFDLIYKFLEIVSGSTRNHKREVLEEALKK-KG 374 Query: 559 EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDL 613 + L+ DYG PPH G +GL RL+ ++TG S+++++ FP+ + Sbjct: 375 LKPESFEFFLKWFDYGMPPHAGFGMGLARLMVMLTGIQSVKEIVPFPRDKKRLTP 429 >5XIX-A nrPDB Length = 472 Score = 256 bits (655), Expect = 2e-68, Method: Composition-based stats. Identities = 76/327 (23%), Positives = 130/327 (39%), Gaps = 35/327 (10%) Query: 59 SSHLGQEVTLCGWIQYRR----QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVES 114 + GQ V + GW+ R FLVLRD G +Q ++ DE +L ES Sbjct: 45 EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLA-DELCQCYNGVL--LSTES 101 Query: 115 VVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYR 174 V V G + P G++ P G E+ EL+ + + ++L R Sbjct: 102 SVAVYGMLNLTPKGKQAP----GGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNR 157 Query: 175 YLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSREP 233 ++ +R M L+ RS + R++ + G+ ++ PTL + + GGA F + Sbjct: 158 HMMIRGENMSKILKARSMVTRCFRDHFFD-RGYYEVTPPTLVQTQVEGGATLFKLDYF-- 214 Query: 234 GKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQTG 292 G+ L QS Q + + + L F +A+ YR E SR R E+T ++ E F+ Sbjct: 215 GEEAFLTQSSQLYLETCLPA-LGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDD 273 Query: 293 IQSLIEGL----------------LQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTR 336 + + +E L + PN + P PF M +++ + Sbjct: 274 LLNRLEDLVCDVVDRILKSPAGSIVHELNPNFQPPK-RPFKRMNYSDAIVWLKEHDVKKE 332 Query: 337 FGMKIIDISDVFRNTEIGFLQDALSKP 363 G D+ E + D +++P Sbjct: 333 DGTFYEFGEDIPEAPE-RLMTDTINEP 358 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 9/108 (8%) Query: 505 TAPHPSDIHLLYTE--PKKAR-SQHYDLVL-NGNEIGGGSIRIHNAELQRYILATLLKE- 559 P +I Y + P+ +R ++ D+++ N EI GGS+RI ++E ILA +E Sbjct: 361 LCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSE---EILAGYKREG 417 Query: 560 -DVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 D YG PHGG LGL+R + + IRDV +P+ Sbjct: 418 IDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPR 465 >1X54-A nrPDB Length = 434 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 74/334 (22%), Positives = 144/334 (43%), Gaps = 41/334 (12%) Query: 53 TCGELRSSHLGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCE 109 C E++ G++V L GW+ + FL +RD G+VQ ++ ++ + + Sbjct: 6 YCQEVKPELDGKKVRLAGWVYTNMRVGKKIFLWIRDSTGIVQAVVAKNVVGEETFEKAKK 65 Query: 110 APVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEAL 169 ES V V G V + + + P G E+ V+ E++ A + P +N + + L Sbjct: 66 LGRESSVIVEGIV------KADERAPGG-AEVHVEKLEVIQAVSEFPIP-ENPEQASPEL 117 Query: 170 RLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLV 228 L YR+L +R+ + ++++ ++M RE+L G+ ++ P L GGA F + Sbjct: 118 LLDYRHLHIRTPKASAIMKVKETLIMAAREWLLK-DGWHEVFPPILVTGAVEGGATLFKL 176 Query: 229 PSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSF 287 K+ L QS Q + + + GL++ + + +R E SR R EF +++E ++ Sbjct: 177 KYF--DKYAYLSQSAQLYLEAAIF-GLEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAW 233 Query: 288 VDQTGIQSLIEGLLQYS------WPNDKDPVVV-----------PFPTMTFAEVLATYGT 330 +D I + E L+ Y + + PFP +++ E + + Sbjct: 234 MDLWDIMKVEEELVSYMVQRTLELRKKEIEMFRDDLTTLKNTEPPFPRISYDEAIDILQS 293 Query: 331 DKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPH 364 + +G + +D E L + +P Sbjct: 294 KGVNVEWGDDL--GAD-----EERVLTEEFDRPF 320 Score = 95.9 bits (237), Expect = 5e-20, Method: Composition-based stats. Identities = 35/127 (27%), Positives = 50/127 (39%), Gaps = 9/127 (7%) Query: 488 LPKEENPRELESAHHPF-TAPHPSDIHLLYTEPKKARSQHY---DLVLNGN--EIGGGSI 541 L +E E PF +P I Y + + D++ EI GGS Sbjct: 304 LGADEERVLTEEFDRPFFVYGYPKHIKAFYMKEDPNDPRKVLASDMLAPEGYGEIIGGSQ 363 Query: 542 RIHNAE-LQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRD 600 R + + L IL + D K L YG+ PH G LG++RL+ V IR Sbjct: 364 REDDYDKLLNRILEEGM--DPKDYEWYLDLRRYGSVPHSGFGLGVERLVAWVLKLDHIRW 421 Query: 601 VIAFPKS 607 FP++ Sbjct: 422 AALFPRT 428 >2XGT-A nrPDB Length = 435 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 75/327 (22%), Positives = 129/327 (39%), Gaps = 36/327 (11%) Query: 60 SHLGQEVTLCGWIQYRRQN----TFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 H + V + GWI R+ F +LRD G +QV++ D+ + + E Sbjct: 8 KHRNERVCIKGWIHRMRRQGKSLMFFILRDGTGFLQVLL-MDKLCQTYDALT--VNTECT 64 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRY 175 V++ G + P G+E P E+ +++ + + + L R+ Sbjct: 65 VEIYGAIKEVPEGKEAPN----GHELIADFWKIIGNAPPGGIDNVLNEEASVDKMLDNRH 120 Query: 176 LDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSREPG 234 L +R LRLR+ MRE+ N G+V++ PTL + + GG+ F + Sbjct: 121 LVIRGENAAALLRLRAAATRAMREHFYNA-GYVEVAPPTLVQTQVEGGSTLFNLDYFGEQ 179 Query: 235 KFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQTGI 293 F L QS Q + + + L F +A+ YR E SR R E+ ++ E F+ + Sbjct: 180 SF--LTQSSQLYLETCI-PTLGDVFCIAQSYRAEKSRTRRHLAEYAHVEAECPFITLDDL 236 Query: 294 QSLIEGLL-----------------QYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTR 336 IE L+ ++ P + P PF M + + + + Sbjct: 237 MEKIEELVCDTVDRLLADEEAKKLLEHINPKFQPP-ERPFLRMEYKDAIKWLQEHNVENE 295 Query: 337 FGMKIIDISDVFRNTEIGFLQDALSKP 363 FG D+ E F+ D ++KP Sbjct: 296 FGNTFTYGEDIAEAAE-RFMTDTINKP 321 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Query: 507 PHPSDIHLLYTE---PKKARSQHYDLVLNG-NEIGGGSIRIHNAELQRYILATLLKEDVK 562 PS+I Y + ++ DL++ G EI GGS+RI + + D K Sbjct: 326 RFPSEIKAFYMQRDAQDNTLTESVDLLMPGVGEIVGGSMRIWKFDELSKAFKNVEI-DPK 384 Query: 563 MLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 L YG PHGG LGL+R IC +T + IRDV +P+ Sbjct: 385 PYYWYLDQRLYGTCPHGGYGLGLERFICWLTNTNHIRDVCLYPR 428 >6AQG-A nrPDB Length = 506 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 73/283 (25%), Positives = 123/283 (43%), Gaps = 27/283 (9%) Query: 50 RTNTCGELRSSHLG--------QEVTLCGWIQYRR---QNTFLVLRDFDGL-VQVIIPQD 97 RT+T E+R+++ V + G + + R + F L+D DG +Q +I D Sbjct: 44 RTHTLAEIRATYADLPTDSATEDIVGVAGRVVFARNTGKLCFATLQDGDGTQLQAMISLD 103 Query: 98 ESA-ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLP 156 E S+ + + + VV V GTVIS G+ + + + K A + LP Sbjct: 104 EVGRESLDRWKADVDIGDVVYVHGTVISSRRGELSVLADSWRMAAK--------ALRPLP 155 Query: 157 FEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTL 215 K +E R++ RY+DL Q + R R ++ +R L GF+++ETP L Sbjct: 156 VAHKEM---SEESRVRQRYVDLIVRPQAREVARQRIAVIRAVRNAL-ERRGFLEVETPML 211 Query: 216 FKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDR 274 G A + F+ S L +P+ F + +VGG DR F++ R +R+EGS Sbjct: 212 QTLAGGAAARPFVTHSNALDIDLYLRIAPELFLKRCIVGGFDRVFELNRVFRNEGSDSTH 271 Query: 275 QPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFP 317 PEF+ ++ ++ + L+Q + P Sbjct: 272 SPEFSMLETYQTYGTYDDSALITRELIQEVADEAIGTRQLSMP 314 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 11/127 (8%) Query: 488 LPKEENPRELESAHHPFTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHN 545 E +A F P + L ++ +DL + G E+ G +++ Sbjct: 375 ELWEHAVGNKLTAP-TFVKDFPVETTPLTRQHRSIPGVTEKWDLYVRGVELATGYSELND 433 Query: 546 AELQRYILATLLKED-------VKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSI 598 +QR A + +++ L AL+YG PP G +G+DRL+ +TG SI Sbjct: 434 PVVQRDRFADQARAAAAGDDEAMQLDEDFLTALEYGMPPCTGTGMGIDRLLMCLTGL-SI 492 Query: 599 RDVIAFP 605 R+ + FP Sbjct: 493 RETVLFP 499 >6AQH-A nrPDB Length = 508 Score = 241 bits (614), Expect = 1e-63, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 127/296 (42%), Gaps = 28/296 (9%) Query: 37 SQRRIPEFSSFVVRTNTCGELRSSH--------LGQEVTLCGWIQYRR---QNTFLVLRD 85 +Q R P + V RT+T E+R ++ G+ V + G + + R + F L++ Sbjct: 35 AQGRQP-YPVDVPRTHTLLEIRQAYPDLPVDARTGEIVGVTGRVVFARNSGKLCFATLQE 93 Query: 86 FDGL-VQVIIPQDESA-ASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKV 143 DG +Q +I E ++ + +V V G VI+ G+ + + ++ K Sbjct: 94 GDGTQLQAMISLAEVGQEALDNWKTYVDIGDIVFVHGEVITSKRGELSVLADSWQMAAK- 152 Query: 144 KTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLC 202 A + LP K +E R++ RY+DL Q + R R ++ +R L Sbjct: 153 -------ALRPLPVAHKEM---SEESRVRQRYVDLIVRDQARKVARQRIAVMRAIRSAL- 201 Query: 203 NLHGFVDIETPTLFKRTPGGA-KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQV 261 GF+++ETP L G A + F+ S L +P+ F + +VGG +R F++ Sbjct: 202 ERRGFLEVETPMLQTLAGGAAARPFVTHSNALDTELYLRIAPELFLKRCLVGGFERVFEL 261 Query: 262 ARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFP 317 R +R+EG+ PEF ++ ++ + L+Q VP P Sbjct: 262 NRVFRNEGADSTHSPEFVMLETYQAYGTYDDSAVVTRELIQEVADEAIGTRQVPLP 317 Score = 93.2 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 35/153 (22%), Positives = 58/153 (37%), Gaps = 30/153 (19%) Query: 460 ADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEP 519 L+E L++ +V DFP+ L +H Sbjct: 374 GKLVEELWEHTVGAKLWAPTFVKDFPV------ETTPLTRSH----------------RS 411 Query: 520 KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILA-------TLLKEDVKMLSHLLQALD 572 ++ +DL + E+ G + + +QR E + + L AL+ Sbjct: 412 IPGVTEKWDLYVRRIELATGYSELTDPIIQRERFEAQARAAAAGDDEAMALDEDFLAALE 471 Query: 573 YGAPPHGGIALGLDRLICLVTGSPSIRDVIAFP 605 YG PP G +G+DRL+ +TG SIR+ + FP Sbjct: 472 YGMPPSTGTGMGIDRLMMTLTGL-SIRETVLFP 503 >3M4P-A nrPDB Length = 456 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 142/328 (43%), Gaps = 34/328 (10%) Query: 59 SSHLGQEVTLCGWIQY----RRQNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVES 114 + G+ VT GW + R+ F+ LRD G Q +I E K + E Sbjct: 26 AGLEGKLVTFKGWAYHIRKARKTLIFVELRDGSGYCQCVIFGKELCEPEK--VKLLTREC 83 Query: 115 VVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEAL--RLQ 172 ++++G + + AG+ +P + ++++ E + P +++N + K ++ ++Q Sbjct: 84 SLEITGRL-NAYAGKNHPPEIADILNLEMQVTEW-KVIGESPIDLENIINKDSSIPQKMQ 141 Query: 173 YRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSR 231 R++ +RS Q L+LRS++ R+Y + H F +I+ PT+ K + GG+ F + Sbjct: 142 NRHIVIRSEHTQQVLQLRSEIQWYFRKYYHDNH-FTEIQPPTIVKTQCEGGSTLFKLQYF 200 Query: 232 EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQ 290 + L QS Q + + ++ L + F + YR E SR R E+ ++ E+ F+ Sbjct: 201 --NEPAYLTQSSQLYLES-VIASLGKSFCMLSSYRAEQSRTVRHLAEYLHLEAELPFISF 257 Query: 291 TGIQSLIEGLL---------------QYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDT 335 + + +E L+ + P+ K P PF MT+A+ + Y D Sbjct: 258 EDLLNHLEDLVCTVIDNVMAVHGDKIRKMNPHLKLPT-RPFKRMTYADAIK-YCNDHGIL 315 Query: 336 RFGMKIIDISDVFRNTEIGFLQDALSKP 363 D+ E + D + P Sbjct: 316 NKDKPFEYGEDISEKPE-RQMTDEIGCP 342 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 37/108 (34%), Positives = 50/108 (46%), Gaps = 7/108 (6%) Query: 504 FTAPHPSDIHLLYTE--PK-KARSQHYDLVLNG-NEIGGGSIRIHNA-ELQRYILATLLK 558 F PS + Y P ++ DL++ G EI GGS+RI N EL A L Sbjct: 344 FMIHFPSKMKAFYMSKVPGHPDLTESVDLLMPGVGEIVGGSMRIWNYDELMGAYKANGLN 403 Query: 559 EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 606 D Q YG+ PHGG LG++RL+ + G IR V +P+ Sbjct: 404 PDPYYW--YTQQRKYGSCPHGGYGLGVERLVMWLLGEDHIRKVCLYPR 449 >6NRZ-A nrPDB Length = 534 Score = 233 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 133/303 (43%), Gaps = 31/303 (10%) Query: 65 EVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESVVQVSGT 121 +V G + R +N F + D D +QV+ +D SA V + +A + + + Sbjct: 74 KVRFAGRLVLFRSMGKNAFGQILDNDAKIQVMFNRDFSA--VAGLAADAGISPIKFIEKK 131 Query: 122 V-ISRPAGQENPKMPT--GEIEIKVKTAELLNACKKL-PFEIKNFVKKTEALRLQYRYLD 177 + + G E T GE+ + V+T LL CK L K+ + +R + R+ D Sbjct: 132 LDLGDILGLEGYLFFTHSGELTVLVETVTLL--CKSLISLPDKHAGLADKEIRYRKRWAD 189 Query: 178 LRS-FQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG-AKEFLVPSREPGK 235 L S ++ RS+++ +REY+ + F+++ETP L G A F+ + Sbjct: 190 LISSEDVRKTFLTRSRILKLIREYM-DQQSFLEVETPILQTVYGGAEATPFVTTLQALHA 248 Query: 236 FYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQS 295 L S + + L+VGG+ R +++ + +R+EG PEFT I+ ++ D + Sbjct: 249 EMFLRISLEIALKKLLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMK 308 Query: 296 LIEGLLQY---SWPNDK----------DPVVVPFP----TMTFAEVLATYGTDKPDTRFG 338 +E L++Y + N + P VV F MT E ++ YG D Sbjct: 309 CVENLVEYIVRALNNGETQVQYSHLKSGPQVVDFKAPWIRMTMKESISVYGGVDVDLHAD 368 Query: 339 MKI 341 ++ Sbjct: 369 HEL 371 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 13/122 (10%) Query: 499 SAHHPFTAPHPSDIHLLYT---EPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILAT 555 + HH HP + L + + ++ G E+ +++ QR +L Sbjct: 409 APHH--ITDHPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPLQQRKLLEE 466 Query: 556 LLKEDV--------KMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 +++ + L+AL G PP GG +G+DRL+ ++T + SIRDV+ FP Sbjct: 467 QMRKKALNPDSEYHPIDEEFLEALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFPVM 526 Query: 608 FR 609 R Sbjct: 527 RR 528 >4J15-A nrPDB Length = 521 Score = 232 bits (592), Expect = 4e-61, Method: Composition-based stats. Identities = 80/342 (23%), Positives = 140/342 (40%), Gaps = 34/342 (9%) Query: 32 SLLQSSQRRIPEFSSFVVRTNTCGELRSSHLGQEVTLCGWIQYRR---QNTFLVLRDFDG 88 S++QS ++ P+ VR +L + V + + R + FLVLR Sbjct: 53 SMIQSQEK--PDRVLVRVR-----DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQF 105 Query: 89 LVQVIIP-QDESAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAE 147 VQ ++ D ++ + K ES+V V G V R Q+ ++E+ V+ Sbjct: 106 NVQALVAVGDHASKQMVKFAANINKESIVDVEGVV--RKVNQKIGSCTQQDVELHVQKIY 163 Query: 148 LLNACKK-LPFEIKNFVKK------------TEALRLQYRYLDLRSFQMQYNLRLRSQMV 194 +++ + LP ++ + V+ + RL R +DLR+ Q RL+S + Sbjct: 164 VISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGIC 223 Query: 195 MKMREYLCNLHGFVDIETPTLFKRT-PGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVG 253 RE L N GFV+I+TP + GGA F V + L QSPQ +KQ+ + Sbjct: 224 HLFRETLIN-KGFVEIQTPKIISAASEGGANVFTVSYFKNNA--YLAQSPQLYKQMCICA 280 Query: 254 GLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSF-VDQTGIQSLIEGLLQYSWPNDKDP 311 ++ F + +R E S R EF +DIEM+F + I + + ++ Sbjct: 281 DFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQER 340 Query: 312 VVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEI 353 T+ + +P R ++ + + R + Sbjct: 341 FQTEIQTVNKQFPCEPFKFLEPTLR--LEYCEALAMLREAGV 380 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 4/108 (3%) Query: 503 PFTAPHPSDIHLLYTEPKKAR---SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKE 559 +P + YT P S YD+ + G EI G+ RIH+ +L A Sbjct: 409 YILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTE-RALHHGI 467 Query: 560 DVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 D++ + + + +GAPPH G +GL+R+ L G ++R FP+ Sbjct: 468 DLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRD 515 >5HGQ-A nrPDB Length = 524 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 107/559 (19%), Positives = 184/559 (32%), Gaps = 127/559 (22%) Query: 67 TLCGWIQYRR----QNTFLVLRDFDGLVQVIIPQDE--SAASVKKILCEAPVESVVQVSG 120 ++ G + +R + F L +QV+ + + ++ V+G Sbjct: 61 SVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNG 120 Query: 121 TVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDL-R 179 + +GE+ I L C + +F K + R + RYLDL Sbjct: 121 ---------YPARSKSGELSIIPYEIIQLTPCLHM-LPHTHFGLKNQETRYRMRYLDLIM 170 Query: 180 SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG-AKEFLVPSREPGKFYS 238 + ++ RS+M+ +R YL NL GF+++ETP + G AK F+ + Sbjct: 171 NPDVKNRFVTRSRMISFLRRYLDNL-GFLEVETPMMNLIAGGATAKPFITHHNDLDMDLY 229 Query: 239 LPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIE 298 L +P+ + ++L+VGG+D R Y E R R ID Sbjct: 230 LRVAPELYLKMLVVGGID------RVY--EIGRVFRN---EGID---------------- 262 Query: 299 GLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQD 358 T+ + F M D D+ + TE L Sbjct: 263 ---------------------------QTHNPEFTSCEFYMAYADYEDLMKITE-DMLAR 294 Query: 359 ALSKPHGTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFI 418 + HGT K P G +++ F + + P A+ + Sbjct: 295 MVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGL-----QEKLGIQFPPADTL 349 Query: 419 MESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSF 478 + + + A E+N C A LL+ +PT S Sbjct: 350 DTDEANKFFDKL-----------AVENNVECPAPRTT----ARLLDKLIGEFLEPTFISP 394 Query: 479 LWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEI 536 F HP + L + ++ ++L + EI Sbjct: 395 T------------------------FLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEI 430 Query: 537 GGGSIRIHNAELQRYILATLLK-------EDVKMLSHLLQALDYGAPPHGGIALGLDRLI 589 +++ QR K E + + AL+YG PP G +G+DRL Sbjct: 431 VNAYTELNDPLTQRLRFDEQAKQKQAGDDEAQNIDENYCTALEYGLPPTAGWGMGIDRLA 490 Query: 590 CLVTGSPSIRDVIAFPKSF 608 ++T S +I++V+ FP Sbjct: 491 MILTDSNNIKEVLFFPAMR 509 >6CHD-A nrPDB Length = 597 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 35/298 (11%) Query: 61 HLGQEVTLCGWIQYRR----QNTFLVLRDFDGLVQVIIPQD--ESAASVKKILCEAPVES 114 + + G I +R + F LR +QV+ +S I + Sbjct: 121 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 180 Query: 115 VVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYR 174 ++ V G K GE+ I LL+ C + +F K + R + R Sbjct: 181 IIGVQG---------NPGKTKKGELSIIPYEITLLSPCLHM-LPHLHFGLKDKETRYRQR 230 Query: 175 YLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSR 231 YLDL + ++ +RS+++ +R +L L GF++IETP + PGGA K F+ Sbjct: 231 YLDLILNDFVRQKFIIRSKIITYIRSFLDEL-GFLEIETPMM-NIIPGGAVAKPFITYHN 288 Query: 232 EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQT 291 E + +P+ + ++L+VGG+DR +++ R +R+EG PEFT + M++ D Sbjct: 289 ELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYH 348 Query: 292 GIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFR 349 + + E ++ + V TY D P+ + +D + FR Sbjct: 349 DLMEITEKMVSGMVKHITGSYKV------------TYHPDGPEGQAYD--VDFTPPFR 392 Score = 128 bits (321), Expect = 8e-30, Method: Composition-based stats. Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 9/114 (7%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK--- 558 F HP + L + K+ ++ ++L + EI +++ QR + K Sbjct: 461 FICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKA 520 Query: 559 --EDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 +D M + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 521 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 574 >6ILH-A nrPDB Length = 521 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 124/298 (41%), Gaps = 35/298 (11%) Query: 61 HLGQEVTLCGWIQYRR----QNTFLVLRDFDGLVQVIIPQD--ESAASVKKILCEAPVES 114 + + G I +R + F LR +QV+ +S I + Sbjct: 53 LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD 112 Query: 115 VVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYR 174 ++ V G K GE+ I LL+ C + +F K + R + R Sbjct: 113 IIGVQG---------NPGKTKKGELSIIPYEITLLSPCLHM-LPHLHFGLKDKETRYRQR 162 Query: 175 YLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA--KEFLVPSR 231 YLDL + ++ +RS+++ +R +L L GF++IETP + PGGA K F+ Sbjct: 163 YLDLILNDFVRQKFIIRSKIITYIRSFLDEL-GFLEIETPMM-NIIPGGAVAKPFITYHN 220 Query: 232 EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQT 291 E + +P+ + ++L+VGG+DR +++ R +R+EG PEFT + M++ D Sbjct: 221 ELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYH 280 Query: 292 GIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFR 349 + E ++ + V TY D P+ + +D + FR Sbjct: 281 DHMEITEKMVSGMVKHITGSYKV------------TYHPDGPEGQAYD--VDFTPPFR 324 Score = 128 bits (321), Expect = 8e-30, Method: Composition-based stats. Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 9/114 (7%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK--- 558 F HP + L + K+ ++ ++L + EI +++ QR + K Sbjct: 393 FICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKA 452 Query: 559 --EDVKML--SHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 +D M + AL+YG PP G +G+DR+ +T S +I++V+ FP Sbjct: 453 AGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMK 506 >6OD8-A nrPDB Length = 558 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 71/279 (25%), Positives = 126/279 (45%), Gaps = 23/279 (8%) Query: 45 SSFVVRTNT-CGEL-RSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIP-QDE 98 +++ RT+ EL R + + V + + R+ F+VLRD VQ + + + Sbjct: 66 TTYKSRTHIPVSELSRPELVDKTVLIRARVSTTRKKGKMAFMVLRDGSDSVQAMAAVEGD 125 Query: 99 SAASVKKILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTA-ELLNACKKLPF 157 + + + ES+V V TV + +IE+KVK + + + LPF Sbjct: 126 VPKEMIDFMGQIATESIVDVEATVCKVEQPITS--TSHSDIELKVKKIHTVTESLRTLPF 183 Query: 158 EIKNFVKKTE--------ALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVD 209 +++ +K RL R++DLR+ RL+S++ R++L + F + Sbjct: 184 TLEDASRKESAEGAKVNLDTRLNSRWMDLRTLASGAIFRLQSRVCQYFRQFLID-KDFCE 242 Query: 210 IETPTLFKR-TPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDE 268 I +P + + GGA F + +F L QSPQ +KQ+++ G + R F+V +R E Sbjct: 243 IHSPKIINAPSEGGANVFKLEYF--NRFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSE 300 Query: 269 GSRPDRQ-PEFTQIDIEMSFVD-QTGIQSLIEGLLQYSW 305 S R EF +D+EM + + + E L Y + Sbjct: 301 NSNTHRHLTEFVGLDVEMRIDEHYYEVLDVAESLFNYIF 339 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 35/119 (29%), Positives = 54/119 (45%), Gaps = 10/119 (8%) Query: 504 FTAP-HPSDIHLLYTEP---KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKE 559 F + PS YT + YD+ + G EI G+ RIH+ +L A +L Sbjct: 446 FISDRFPSSARPFYTMECKDDVRFTNSYDMFIRGEEISSGAQRIHDPDLL-LARAKMLNV 504 Query: 560 DVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTP 618 D+ + + + GA PHGG +GL+R++ L G ++R FP+ D TP Sbjct: 505 DLTPIKEYVDSFRLGAWPHGGFGIGLERVVMLYLGLSNVRLASLFPR-----DPQRTTP 558 >5ELO-A nrPDB Length = 535 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 121/275 (44%), Gaps = 24/275 (8%) Query: 55 GELRSSHLGQEVTLC--GWIQYRR----QNTFLVLRDFDGLVQVIIP---QDESAASVKK 105 G + + ++ ++ TL G + R + F + + VQ+I D S Sbjct: 60 GNVENGYIDKDTTLSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIMEHDISTGEFSV 119 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNAC-KKLPFEIKNFVK 164 E VV +G K GE+ + K+ LL+ C LP I Sbjct: 120 SHSEIRRGDVVGFTG---------FPGKSKRGELSLFSKSVVLLSPCYHMLPTAISGL-- 168 Query: 165 KTEALRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGA 223 K + +R + RYLDL + + + +LRS+ + +R Y + GF+++ETP L G A Sbjct: 169 KDQEVRYRQRYLDLMLNEESRKVFKLRSRAIKYIRNYF-DRLGFLEVETPMLNMIYGGAA 227 Query: 224 -KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQID 282 + F+ E + +P+ + + L+VGGLD+ +++ + +R+EG PEFT ++ Sbjct: 228 ARPFITYHNELETQLYMRIAPELYLKQLIVGGLDKVYEIGKNFRNEGIDLTHNPEFTAME 287 Query: 283 IEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFP 317 M++ D + L E L+ + +P+ Sbjct: 288 FYMAYADYYDLMDLTEELISGLVLEIHGSLKIPYH 322 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 9/114 (7%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK--- 558 F HP + L + K ++ ++L + G E+ ++ QR Sbjct: 407 FIIDHPQTMSPLAKWHREKPEMTERFELFVLGKELCNAYTELNEPLQQRKFFEQQADAKA 466 Query: 559 ----EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 E + AL++G PP GG LG+DRLI + +I++VI FP Sbjct: 467 SGDVEACPIDETFCLALEHGLPPTGGWGLGIDRLIMFLADKNNIKEVILFPAMR 520 >1ASZ-A nrPDB Length = 490 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 121/319 (37%), Gaps = 46/319 (14%) Query: 50 RTNTCGELRSSHLGQEVTLCGWIQYRRQN----TFLVLRDFDGLVQVIIPQDESAASVKK 105 R + +EV + RQ FL LR L+Q ++ ++ K Sbjct: 26 RVKFVDLDEAKDSDKEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKN 85 Query: 106 ILCEAP---VESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNF 162 ++ A +ES+V V G V ++ + EI I K + + LP +++ Sbjct: 86 MVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHI-TKIYTISETPEALPILLEDA 144 Query: 163 VKKTEA------------LRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDI 210 + RL YR +DLR+ Q R+++ + REYL F ++ Sbjct: 145 SRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLATKK-FTEV 203 Query: 211 ETPTLFKR-TPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEG 269 TP L + GG+ F V + L QSPQ KQ L+V +R +++ +R E Sbjct: 204 HTPKLLGAPSEGGSSVFEVTYFK--GKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAEN 261 Query: 270 SRPDRQ-PEFTQIDIEMSFVD-QTGIQSLIEGLLQYSWP--------------------N 307 S R EFT +D+EM+F + + + L + + Sbjct: 262 SNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSELPKRFAHEIELVRKQYPVEE 321 Query: 308 DKDPVVVPFPTMTFAEVLA 326 K P +T+ E + Sbjct: 322 FKLPKDGKMVRLTYKEGIE 340 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 34/109 (31%), Positives = 46/109 (42%), Gaps = 4/109 (3%) Query: 503 PFTAPHPSDIHLLYTEPKKAR---SQHYDLVLNGNEIGGGSIRIHNA-ELQRYILATLLK 558 P +I YT P A S YD + G EI G+ RIH+ LQ + A L Sbjct: 376 YILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLS 435 Query: 559 EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 + L YG PPH G +GL+R++ +IR FP+ Sbjct: 436 PEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFPRD 484 >1N9W-A nrPDB Length = 422 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 133/295 (45%), Gaps = 43/295 (14%) Query: 59 SSHLGQEVTLCGWIQYRRQNT---FLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 +H+GQEV L G++ +RR FL+LRD G+VQV+ + ES Sbjct: 9 KAHVGQEVELLGFLHWRRDLGRIQFLLLRDRSGVVQVVTGGLKLPLP----------ESA 58 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLN-ACKKLPFE-IKNFVKKTEALRLQY 173 ++V G V+ EN K P G +E++ K E+L+ A + P E K + L+Y Sbjct: 59 LRVRGLVV------ENAKAPGG-LEVQAKEVEVLSPALEPTPVEIPKEEWRANPDTLLEY 111 Query: 174 RYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKEFLVPSRE 232 RY+ LR + + L++++ +V R YL + F +I TP + + GG+ F V E Sbjct: 112 RYVTLRGEKARAPLKVQAALVRGFRRYL-DRQDFTEIFTPKVVRAGAEGGSGLFGVDYFE 170 Query: 233 PGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFV-DQ 290 L QSPQ +KQ +MVG +R ++VA +R E R E+ +D+EM F+ D+ Sbjct: 171 KRA--YLAQSPQLYKQ-IMVGVFERVYEVAPVWRMEEHHTSRHLNEYLSLDVEMGFIADE 227 Query: 291 TGIQSLIEGLLQYSWPNDK--------------DPVVVPFPTMTFAEVLATYGTD 331 + L E LL P +T AE + Sbjct: 228 EDLMRLEEALLAEMLEEALNTAGDEIRLLGATWPSFPQDIPRLTHAEAKRILKEE 282 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 35/106 (33%), Positives = 50/106 (47%), Gaps = 2/106 (1%) Query: 504 FTAPHPSDIHLLYTEPK-KARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVK 562 F +P + YT P+ ++ +DL+ G EI G RIH E L D + Sbjct: 313 FVTRYPRSVRPFYTYPEEDGTTRSFDLLFRGLEITSGGQRIHRYEELLESLKA-KGMDPE 371 Query: 563 MLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 L+ YG PPHGG A+G +RL + G P++R AFP+ Sbjct: 372 AFHGYLEVFKYGMPPHGGFAIGAERLTQKLLGLPNVRYARAFPRDR 417 >5ZG8-A nrPDB Length = 438 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 118/291 (40%), Gaps = 35/291 (12%) Query: 59 SSHLGQEVTLCGWIQYRRQNT---FLVLRDFDGLVQVIIPQDESAASVKKILCEAPVESV 115 + H+ QEV L GW+ RR FL+LRD G +Q + Q E +V + P E+ Sbjct: 9 ARHVDQEVELRGWLYQRRSKGKIHFLILRDGTGFLQATVVQGEVPEAVFREADHLPQETA 68 Query: 116 VQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFVKKTEALRLQYR 174 ++V G V E+ + P G E+ V+ ++++ + + P K + +R Sbjct: 69 LRVWGRVR------EDRRAPGG-FELAVRDLQVVSRPQGEYPIGPKE---HGIDFLMDHR 118 Query: 175 YLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGGAKEFLVPSREPG 234 +L LR + +R+R ++ + E+ GF+ + P L G E G Sbjct: 119 HLWLRHRRPFAVMRIRDELERAIHEFFGE-RGFLRFDAPILTPSAVEGTTELFEVELFDG 177 Query: 235 KFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVDQTGI 293 + L QS Q + + + + + +R E S+ R EF ++ E++F+ Sbjct: 178 EKAYLSQSGQLYAEAGALA-FAKVYTFGPTFRAERSKTRRHLLEFWMVEPEVAFMTHEEN 236 Query: 294 QSLIEGLLQYSWPND------------------KDPVVVPFPTMTFAEVLA 326 +L E L+ + + +P +T+ E +A Sbjct: 237 MALQEELVSFLVARVLERRSRELEMLGRDPKALEPAAEGHYPRLTYKEAVA 287 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%) Query: 504 FTAPHPSDIHLLYTEPKKARSQHYDLVLNG--------NEIGGGSIRIHNAEL-QRYILA 554 F +P+ I Y EP + +LVLN EI GGS RIH+ EL +R I Sbjct: 325 FVERYPARIKAFYMEPDP---EDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQE 381 Query: 555 TLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSF 608 L E+V L +G+ PH G LGL+R + + G +R+ I FP+ + Sbjct: 382 FGLPEEV--YDWYLDLRRFGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRMY 433 >4YCV-A nrPDB Length = 516 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 118/296 (39%), Gaps = 39/296 (13%) Query: 59 SSHLGQEVTLCGWIQYR----RQNTFLVLRDFDGLVQVIIP---QDESAASVKKILCEAP 111 + + G I ++ F L +QV+ + + + + Sbjct: 51 EHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIR 110 Query: 112 VESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRL 171 +V + G K GE+ I K LL+AC + +K + K +R Sbjct: 111 RGDIVGIVG---------FPGKSKKGELSIFPKETILLSACLHM-LPMK-YGLKDTEIRY 159 Query: 172 QYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG-AKEFLVP 229 + RYLDL + ++ R++++ +R +L N GF ++ETP + G A+ F+ Sbjct: 160 RQRYLDLLINESSRHTFVTRTKIINFLRNFL-NERGFFEVETPMMNLIAGGANARPFITH 218 Query: 230 SREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVD 289 + L + + ++L+VGG+D+ +++ + +R+EG PEFT + ++ D Sbjct: 219 HNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYAD 278 Query: 290 QTGIQSLIEG----LLQYSW-----------PNDKDPVVV---PFPTMTFAEVLAT 327 + E L+ + + P ++ + P+P ++ E + Sbjct: 279 YNDLIKWSEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEK 334 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 31/116 (26%), Positives = 52/116 (44%), Gaps = 9/116 (7%) Query: 504 FTAPHPSDIHLL--YTEPKKARSQHYDLVLNGNEIGGGSIRIHNA-------ELQRYILA 554 F HP + L Y K ++ ++ + G E+ +++ +LQ+ Sbjct: 392 FIVEHPQIMSPLAKYHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFKLQQKDRE 451 Query: 555 TLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRG 610 E ++ S +L+YG PP GG+ LG+DR+ +T SI+DVI FP Sbjct: 452 KGDTEAAQLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRPA 507 >3I7F-A nrPDB Length = 548 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 76/351 (21%), Positives = 128/351 (36%), Gaps = 85/351 (24%) Query: 56 ELRSSHLGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVIIPQDE-SAASVKKILCEAP 111 EL + + VT+ +Q R FL LR Q ++ + E + + + Sbjct: 55 ELVPAMAEKTVTIRARVQAVRGKGNMVFLFLRKGIYTCQALVMKSETISKEFVQFCQKIS 114 Query: 112 VESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFV------- 163 ES+ ++G V + E K ++EI V + +++ + LP +I++ Sbjct: 115 AESICDITGIVKAVEKPIE--KATQQDVEIHVTSIAVVSLAEYPLPMQIEDLTFPSSVFK 172 Query: 164 KKTEA------------------------------------------------LRLQYRY 175 K+ E RL R Sbjct: 173 KQEEDIAKVDEKIAKFLKDNEGKDLTKRPLKDEYAKLLKEKASAQKYVKVSQDTRLDNRM 232 Query: 176 LDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFK-RTPGGAKEFLVPSREPG 234 LDLR+ R++S RE+L + FV+I TP L + GG+ F V Sbjct: 233 LDLRTVTNIAIFRIQSACCGLFREFLTSQK-FVEIHTPKLIGCSSEGGSNIFEVKYF--D 289 Query: 235 KFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVD-QTG 292 + L QSPQ +KQ+ ++G + F+V +R E S R EF +DIEM V+ Sbjct: 290 RKAYLAQSPQLYKQMAIMGDFRKVFEVGPVFRAENSNTRRHLTEFEGLDIEMEIVENYHE 349 Query: 293 IQSLIEGLLQYSWPN-----------------DKDPVVVPFPTMTFAEVLA 326 ++E L + + +D + PF +T+ E + Sbjct: 350 CIDVMEKLFTFIFDEIPKRFPDELKVIRKQYPFEDLIYRPFLRLTYKEAIE 400 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 8/110 (7%) Query: 503 PFTAPHPSDIHLLYTEPK---KARSQHYDLVLNGNEIGGGSIRIHNAE--LQRYILATLL 557 P+ I YT P S YD+ + G EI G+ RIH+ E ++R I + Sbjct: 436 YILDKFPAAIRPFYTMPDIDDPNYSNSYDVFVRGQEITSGAQRIHDPEFLMKRCIEKGV- 494 Query: 558 KEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKS 607 D L +++ +G+ PH G +GL+R+ L G P+IR V FP+ Sbjct: 495 --DPATLKDYIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVTLFPRD 542 >3G1Z-A nrPDB Length = 326 Score = 139 bits (351), Expect = 3e-33, Method: Composition-based stats. Identities = 37/181 (20%), Positives = 71/181 (39%), Gaps = 19/181 (10%) Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG------AKEFLVPSREPGKFYSL 239 NL R+ ++ ++R + + G +++ETP + + T F+ P G L Sbjct: 16 NLLKRAAIMAEIRRFFAD-RGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGINLYL 74 Query: 240 PQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEG 299 SP+ + L+ G FQ+ R +R+E PEFT ++ D + + ++ Sbjct: 75 MTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNEVDD 134 Query: 300 LLQYSWPNDKDPVVVPFPTMTFAEVLAT------YGTDKPDTRFGMKIIDISDVFRNTEI 353 LLQ P ++++ + DK R +D+S++ E Sbjct: 135 LLQQVL------DCQPAESLSYQQAFQRHLEIDPLSADKTQLREAAAKLDLSNIADTEED 188 Query: 354 G 354 Sbjct: 189 R 189 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 9/110 (8%) Query: 504 FTAPHPSDIHLLYTEP--KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK--- 558 F P+ L ++ +++ G E+ G + +A Q+ + Sbjct: 212 FIYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRA 271 Query: 559 ----EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAF 604 + +LL AL G P G+ALG+DRL+ L G+ S+ DVIAF Sbjct: 272 ARGLPQQPIDQNLLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAF 321 >3A5Z-A nrPDB Length = 328 Score = 132 bits (331), Expect = 6e-31, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 72/180 (40%), Gaps = 22/180 (12%) Query: 186 NLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTPGG------AKEFLVPSREPGKFYSL 239 NL R+ ++ ++R + + G +++ETP + + T F+ P G L Sbjct: 18 NLLKRAAIMAEIRRFFAD-RGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWL 76 Query: 240 PQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEG 299 SP+ + L+V G FQ+ R +R+E PEFT ++ D + + ++ Sbjct: 77 MTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDD 136 Query: 300 LLQYSWPNDKDPVVVPFPTMTFAEVLATY------GTDKPDTR---FGMKIIDISDVFRN 350 LLQ ++++ + Y DK R + + +++D + Sbjct: 137 LLQQVLDCPAAE------SLSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSNVADTEED 190 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 48/110 (43%), Gaps = 9/110 (8%) Query: 504 FTAPHPSDIHLLYTEP--KKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK--- 558 F P+ L ++ +++ G E+ G + +A Q+ + Sbjct: 214 FVYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRA 273 Query: 559 ----EDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAF 604 + +L++AL G P G+ALG+DRL+ L G+ ++ +VIAF Sbjct: 274 ARGLPQHPIDQNLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAF 323 >5GRO-A nrPDB Length = 115 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 37/103 (35%), Positives = 57/103 (55%), Gaps = 6/103 (5%) Query: 49 VRTNTCGELRSSHLGQEVTLCGWIQYRRQN---TFLVLRDFDGLVQVIIPQDESAASVKK 105 +R++ C E+ +G+ V + GW R + F+ LRD GLVQ++ D S+ + +K Sbjct: 12 MRSHFCTEISEKDVGKIVKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVC--DPSSKAYEK 69 Query: 106 ILCEAPVESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAEL 148 L E E V+ G V R AG ENPK+ TG+IEI ++ + Sbjct: 70 AL-EVRSEFVLVAKGKVRLRGAGLENPKLKTGKIEIVLEELII 111 >3P8T-A nrPDB Length = 294 Score = 78.6 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 66/173 (38%), Gaps = 20/173 (11%) Query: 176 LDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRT--------PGGAKEFL 227 +++ S + + ++++++ M ++ + GF + L T G + Sbjct: 4 VEIISRDIYKAIDIQTKILDYMTKFFTD-RGFKWLLPIMLSPITDPLWPDPAGEGIRPAE 62 Query: 228 VPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDE---GSRPDRQPEFTQIDIE 284 V G L S KQL + GL++ F ++ R E EFTQ+D E Sbjct: 63 VDVY--GVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFE 120 Query: 285 MSFVDQTGIQSLIEGLL------QYSWPNDKDPVVVPFPTMTFAEVLATYGTD 331 + + LIE L+ W + P F + ++L +G+D Sbjct: 121 IEGAKMKDVMRLIEELIYGLFRKAEEWTGREFPRARHFKVYDYKDILEEFGSD 173 Score = 66.3 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 10/126 (7%) Query: 486 LFLPKEENPRELESAHHPF-TAPHPSDIHLLYTEPKKARSQHYDLVLNGN--EIGGGSIR 542 + + + PF P + Y + ++YDL+L E+ G R Sbjct: 166 ILEEFGSDEKASMEMEEPFWIVNIPRE---FYDREENGVWKNYDLILPYGYGEVSSGGER 222 Query: 543 IHNAE-LQRYILATLLKEDVKMLSHLLQALDYG-APPHGGIALGLDRLICLVTGSPSIRD 600 E + I A LKED L+ G P G +G++RL+ + G+ I + Sbjct: 223 EWEYEKIVAKIRAAGLKED--SFRPYLEIARAGKLKPSAGAGIGVERLVRFIVGAKHIAE 280 Query: 601 VIAFPK 606 V FP+ Sbjct: 281 VQPFPR 286 >1NNH-A nrPDB Length = 294 Score = 75.1 bits (183), Expect = 9e-14, Method: Composition-based stats. Identities = 38/171 (22%), Positives = 65/171 (38%), Gaps = 16/171 (9%) Query: 176 LDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRT------PGGAKEFLVP 229 +++ S ++ L ++++++ M ++ GF + + T P G Sbjct: 4 VEIISREISPTLDIQTKILEYMTDFFVK-EGFKWLLPVIISPITDPLWPDPAGEGMEPAE 62 Query: 230 SREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDE---GSRPDRQPEFTQIDIEMS 286 G L S KQL + GL + F ++ R E EFTQ+D E+ Sbjct: 63 VEIYGVKMRLTHSMILHKQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVE 122 Query: 287 FVDQTGIQSLIEGLL------QYSWPNDKDPVVVPFPTMTFAEVLATYGTD 331 I LIE L+ W + P F ++EVL +G+D Sbjct: 123 RAKMEDIMRLIERLVYGLFRKAEEWTGREFPKTKRFEVFEYSEVLEEFGSD 173 Score = 62.4 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 10/126 (7%) Query: 486 LFLPKEENPRELESAHHPF-TAPHPSDIHLLYTEPKKARSQHYDLVLNGN--EIGGGSIR 542 + + + + PF P + Y ++YDL+L E+ G R Sbjct: 166 VLEEFGSDEKASQEMEEPFWIINIPRE---FYDREVDGFWRNYDLILPYGYGEVASGGER 222 Query: 543 IHNAE-LQRYILATLLKEDVKMLSHLLQALDYG-APPHGGIALGLDRLICLVTGSPSIRD 600 E + I L ED L+ G P G +G++RL+ + G+ I + Sbjct: 223 EWEYEKIVAKIRKAGLNED--SFRPYLEIAKAGKLKPSAGAGIGVERLVRFIVGAKHIAE 280 Query: 601 VIAFPK 606 V FP+ Sbjct: 281 VQPFPR 286 >3VQX-A nrPDB Length = 291 Score = 55.5 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 68/201 (33%), Gaps = 17/201 (8%) Query: 124 SRPAGQENPKMPTGEIEIKVKTAELLNACKKLPFEIKNFVKKTEALRLQYRYLDLRSFQM 183 P G P + LLN ++ ++ E+ L R DL+ Sbjct: 14 LVPRGSHMASAPALTKSQTDRLEVLLNPKDEISLNSGKPFRELESELLSRRKKDLQQIYA 73 Query: 184 QYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKRTP------GGAKEFLVPSREPGKFY 237 + ++ ++ + + GF++I++P L E K + Sbjct: 74 EERENYLGKLEREITRFFVD-RGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVDKNF 132 Query: 238 SLP--QSPQQF-----KQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEM--SFV 288 L +P + + + + F++ CYR E + EFT ++ S Sbjct: 133 CLRPMLAPNLYNYLRKLDRALPDPI-KIFEIGPCYRKESDGKEHLEEFTMLNFCQMGSGC 191 Query: 289 DQTGIQSLIEGLLQYSWPNDK 309 + ++S+I L + + K Sbjct: 192 TRENLESIITDFLNHLGIDFK 212 >2ZNJ-A nrPDB Length = 308 Score = 51.6 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 36/182 (19%), Positives = 62/182 (34%), Gaps = 27/182 (14%) Query: 173 YRYLD-LRSFQMQ-YNLRLRSQMVMKMREYLCNLHGFVDIETPTLF------KRTPGGAK 224 R+L+ LR+ + + L L ++ + + GFV + TPT+ K T G Sbjct: 78 KRHLEQLRTVKHRPALLELEEKLAKALHQ-----QGFVQVVTPTIITKSALAKMTIGEDH 132 Query: 225 EFLVPSREPGKFYSLP--QSPQQF-----KQLLMVGGLDRYFQVARCYRDEGSRPDRQPE 277 L +P + + L + R F++ CYR E E Sbjct: 133 PLFSQVFWLDGKKCLRPMLAPNLYTLWRELERLWDKPI-RIFEIGTCYRKESQGAQHLNE 191 Query: 278 FTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRF 337 FT +++ +E + ++ + F +T E YG D D Sbjct: 192 FTMLNLTELGTPLEERHQRLEDMARWVLEAAG---IREFELVT--ESSVVYG-DTVDVMK 245 Query: 338 GM 339 G Sbjct: 246 GD 247 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 29/90 (32%), Gaps = 24/90 (26%) Query: 512 IHLLY--TEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQ 569 I TE D++ E+ G++ H + + I Sbjct: 224 IREFELVTESSVVYGDTVDVMKGDLELASGAMGPHFLDEKWEIFD--------------- 268 Query: 570 ALDYGAPPHGGIALGLDRLICLVTGSPSIR 599 P G+ GL+RL+ + G+ ++ Sbjct: 269 -------PWVGLGFGLERLLMIREGTQHVQ 291 >6JP2-A nrPDB Length = 278 Score = 45.1 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 34/92 (36%), Gaps = 12/92 (13%) Query: 204 LHGFVDIETPT------LFKRTPGGAKEFLVPSREPGKFYSLP--QSPQQFKQLLMV--- 252 GF+++ TP L + T K + +L +P + + + Sbjct: 79 AEGFIEVRTPIFISKDALARMTITEDKPLFKQVFWIDEKRALRPMLAPNLYSVMRDLRDH 138 Query: 253 -GGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 283 G + F++ C+R E EFT +++ Sbjct: 139 TDGPVKIFEMGSCFRKESHSGMHLEEFTMLNL 170 >11AS-A nrPDB Length = 330 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 1/67 (1%) Query: 535 EIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTG 594 E+ IR+ +A+ ++ LA ED L L P G +G RL L+ Sbjct: 248 ELSSMGIRV-DADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQ 306 Query: 595 SPSIRDV 601 P I V Sbjct: 307 LPHIGQV 313 >2D6F-C nrPDB Length = 619 Score = 37.4 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 56/168 (33%), Gaps = 22/168 (13%) Query: 339 MKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLK-RKDIESIRNFAADHFNQ 397 KI D+S+VF +TE + A S ++ G + R+ + ++A Sbjct: 275 DKIFDVSEVFADTESRIISSAESVLAVKLRGFDGLIGVEIQPGRRLGTEMADYAKKRGVS 334 Query: 398 EILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRL 457 I + + I E + L + + D V++ A E A + L ++ Sbjct: 335 GIFHT--DELPAYG------ITEEEVRGLRDAVGASQGDAVVMVAHERVTAENALREVIR 386 Query: 458 ECADLLETRGVVLRD-------------PTLFSFLWVVDFPLFLPKEE 492 ++ R PT D PLF +++ Sbjct: 387 RAEMAIQGVPEETRKALPDGNTQYLRPLPTSSRMYLETDIPLFRIEDD 434 >3L4G-A nrPDB Length = 508 Score = 37.4 bits (85), Expect = 0.022, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 14/26 (53%) Query: 257 RYFQVARCYRDEGSRPDRQPEFTQID 282 +YF + R +R+E EF QI+ Sbjct: 349 KYFSIDRVFRNETLDATHLAEFHQIE 374 >3M8U-A nrPDB Length = 522 Score = 35.8 bits (81), Expect = 0.051, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 25/68 (36%), Gaps = 12/68 (17%) Query: 242 SPQQFKQLLMVGGLDRYFQ----VARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLI 297 SP++ KQLL G + F+ V R P R E Q D E + Sbjct: 329 SPEKAKQLLKEAGFENGFETDIWVQPVVRASNPNPRRMAELVQSDWEK--------VGVK 380 Query: 298 EGLLQYSW 305 L+ Y W Sbjct: 381 SKLVSYEW 388 >5AYL-A nrPDB Length = 783 Score = 35.1 bits (79), Expect = 0.089, Method: Composition-based stats. Identities = 20/171 (11%), Positives = 44/171 (25%), Gaps = 17/171 (9%) Query: 258 YFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTG-IQSLIEGLLQYS--WPNDKDPVVV 314 + +E + + E +D + + + + + + N Sbjct: 548 VVSLTPSTFNELVKQRKHDEVWMVDFYSPWSHPSQVLMPEWKRMARTLTGLINVGSVDCQ 607 Query: 315 PFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPE 374 + + E + Y P+ RF + Q Sbjct: 608 QYHSFCTQENVQRY----PEIRF----------YPQKSSKAYQYHSYNGWNRDAYSLRSW 653 Query: 375 GAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLE 425 G +L + I+ + Q ++ W+ P NF E + L Sbjct: 654 GLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWSGPSQNFAPEFELLA 704 >5E3I-A nrPDB Length = 438 Score = 35.1 bits (79), Expect = 0.092, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 62/199 (31%), Gaps = 29/199 (14%) Query: 186 NLRLRSQMVMKMREYLC---NLHGFVDIETPT-----LFKRTPGGAKE--------FLVP 229 L ++ ++ ++L + +G+ I P LFKR G A + F Sbjct: 21 VLPTQTAAWRRLEQHLASLMDAYGYQQIRLPIVEQTGLFKRAIGDATDIVEKEMYTFFDK 80 Query: 230 SREPGKFYSLPQSPQ--------QFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQI 281 P L P+ + L+ G R + + +R E + R +F Q Sbjct: 81 GNPPES---LTLRPEGTAGCVRALVEHNLLRGATPRVWYMGPMFRYEKPQKGRYRQFHQF 137 Query: 282 DIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKI 341 +E V I + + L W +V T E F + Sbjct: 138 GVETFGVATPDIDAELIMLTARLWKRMGVDHMVQLELNTLGETDERTEYRNALVAFLNEH 197 Query: 342 IDISDVFRNTEIGFLQDAL 360 D D +++ + L Sbjct: 198 KDALD--EDSQRRLTTNPL 214 >1IYW-A nrPDB Length = 862 Score = 35.1 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 55/290 (18%), Positives = 93/290 (32%), Gaps = 39/290 (13%) Query: 152 CKKLPFEIKNFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIE 211 L F + + +RL R+L +M N +++ R L + GF E Sbjct: 548 ADALRFALIYLATGGQDIRLDLRWL-----EMARNFA--NKLYNAARFVLLSREGFQAKE 600 Query: 212 -TPTLF-----KRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVA-RC 264 TPTL R G +E L Q+ ++ +L+ D Y + A Sbjct: 601 DTPTLADRFMRSRLSRGVEEITALYEALD----LAQAAREVYELVWSEFCDWYLEAAKPA 656 Query: 265 YRDEGSRPDRQPE------FTQIDIEMSFVDQTGIQSLI--EGLLQYSWPNDKDPV---V 313 + + R E + M F+ Q+L E L +WP Sbjct: 657 LKAGNAHTLRTLEEVLAVLLKLLHPMMPFLTSELYQALTGKEELALEAWPEPGGRDEEAE 716 Query: 314 VPFPTM----TFAEVLATYGTDKPDTRFGMKII-DISDVFRNTE-IGFLQDALSKPHGTV 367 F + T L P + + + + V N E FL A P Sbjct: 717 RAFEALKQAVTAVRALKAEAGLPPAQEVRVYLEGETAPVEENLEVFRFLSRADLLPERPA 776 Query: 368 KAIC--IPEGAKYLKRKDIESIRNFAADHFN--QEILPVFLNANRNWNSP 413 KA+ +P + + + + + +E+L + + R SP Sbjct: 777 KALVKAMPRVTARMPLEGLLDVEEWRRRQEKRLKELLALAERSQRKLASP 826 >4LNS-A nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 28/67 (41%), Gaps = 1/67 (1%) Query: 535 EIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTG 594 E+ IR++ AE R+ ++ + + Q L+ P G +G R++ + Sbjct: 270 EVSSMGIRVN-AEALRHQISLTGDDSLLKSEWHQQLLNGEFPQTVGGGIGQSRMVMFMLR 328 Query: 595 SPSIRDV 601 I +V Sbjct: 329 KKHIGEV 335 >6NCZ-A nrPDB Length = 610 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 42/129 (32%), Gaps = 2/129 (1%) Query: 267 DEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLA 326 +E + D + +F + E + + L+ + +D ++ + E Sbjct: 415 NENADTDERLKFMSVLAECAHREDETRMVSAACLVNAAKNKIEDRLMEYLDIIGINEYCG 474 Query: 327 TYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIES 386 Y D M+ TE G DAL HGT+ E + K I + Sbjct: 475 WYTPDFAMLPALMENSQPDKPVIVTEFGA--DALPHHHGTISDKGTEECQADVYEKQIAT 532 Query: 387 IRNFAADHF 395 +RN Sbjct: 533 LRNIDYIKG 541 >1ZQ1-C nrPDB Length = 633 Score = 34.3 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 31/149 (20%), Positives = 60/149 (40%), Gaps = 14/149 (9%) Query: 308 DKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTV 367 + V + + L G D + + D++D+F NT+ + + K G V Sbjct: 255 IEREVERQLNLLKIRDELRKRGVKPKDIK--EEFYDVTDIFENTKSKIIARVIKK-GGKV 311 Query: 368 KAICIPEGAKYLKRKDIESIRNFAADHFNQEILPV----FLNANRNWNSPVANFIMESQR 423 AI +P+ + R +I+ R + ++ V ++ N+ I + + Sbjct: 312 LAIKLPKFRGLIGR-EIQPGRRLGTEFADRAKKYVPGIFHIDELPNYG------ISQEEV 364 Query: 424 LELIRLMETQEEDVVLLTAGEHNKACSLL 452 ++I + EED +L A E KA + L Sbjct: 365 NKVIERLNLSEEDAFVLVAAEEEKAKNAL 393 >2Y8V-A nrPDB Length = 290 Score = 33.2 bits (74), Expect = 0.41, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 32/87 (36%), Gaps = 2/87 (2%) Query: 367 VKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLEL 426 VK + + GA + ++ + ++ + V + + V + + L Sbjct: 86 VKVMGMLGGAAQGSYRCLDGDQEKFERYYQPLLAMVRRHQLDGLDLDVEEEMSLPGIIRL 145 Query: 427 IRLMETQEEDVVLLTAGEHNKACSLLG 453 I ++ D ++T A +LLG Sbjct: 146 IDRLKLDLGDDFIITLAP--VAAALLG 170 >6HIV-DP nrPDB Length = 274 Score = 32.8 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 2/54 (3%) Query: 1 MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPE--FSSFVVRTN 52 M + +WL L R +RP QP+W S R +L+ + PE +V+ + Sbjct: 45 MLYQAWLGGLDRPYTRPKCMANQPLWLSKKRHMLRKERLDGPETPLEKYVLEWH 98 >5MEK-A nrPDB Length = 322 Score = 32.4 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 35/136 (25%), Gaps = 35/136 (25%) Query: 431 ETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRG----VVLRDPTLFSFLWVVDFPL 486 + + D L + L L A+ ++ R+P F +DFP Sbjct: 55 QARPSD--FLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNPHEFVPYIEIDFPF 112 Query: 487 FLPKE---ENPRELESAHHP----------------FTAPHPSDI----------HLLYT 517 F + + L S H P + P D Sbjct: 113 FPEVDVLKDKGNTLFSTHIPYELLPDSVVKSGCKMVYIWREPKDTFISMWTFLHKERTEL 172 Query: 518 EPKKARSQHYDLVLNG 533 P + +D+ G Sbjct: 173 GPVSNLEESFDMFCRG 188 >2DU4-A nrPDB Length = 534 Score = 32.0 bits (71), Expect = 0.91, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 21/39 (53%), Gaps = 2/39 (5%) Query: 572 DYGAP-PHGGIALGLDRLICLVTGSPSIRDVIAFPKSFR 609 +Y P P + LG++RL ++ G +R ++ +P+ Sbjct: 316 EYDIPYPVMNLGLGVERLAMILYGYDDVRKMV-YPQIHG 353 >6DXS-A nrPDB Length = 342 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 35/96 (36%), Gaps = 11/96 (11%) Query: 540 SIRIHNAELQRYILATLLK--EDVKMLSHLLQALDYGAPPHGGIALGLDRLIC--LVTGS 595 I + E++ I A L+ ++ + PH G D+ + Sbjct: 37 YPEISDDEIRETIEANQLRLIKERGADMTIFSPRASAMAPHVG-----DQSVAVPWAQAC 91 Query: 596 PSI--RDVIAFPKSFRGHDLMSNTPDSVPPEELKPY 629 ++ R V FP++F G ++ +P++ + Sbjct: 92 NNLIARVVDLFPETFAGVCMLPQSPEADMTSSIAEL 127 >4JH6-A nrPDB Length = 138 Score = 31.2 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 22/124 (17%), Positives = 39/124 (31%), Gaps = 24/124 (19%) Query: 238 SLPQSPQQFKQLLMVGGLDR-----YFQVARCY--RDEGSRPDRQ---PEFTQIDIEMSF 287 +L S + ++++L L R YF + + +E R +T I + Sbjct: 14 NLEDSIEFYEKVLEGELLVRGRKLAYFNICGVWVALNEEIHIPRNEIYQSYTHIAFSVEQ 73 Query: 288 VDQTGIQSLIEGLLQYSWPNDKDPVVV--------------PFPTMTFAEVLATYGTDKP 333 D + +E + + V F + T + L Y DKP Sbjct: 74 KDFESLLQRLEENDVHILKGRERDVRDCESIYFVDPDGHKFEFHSGTLQDRLNYYREDKP 133 Query: 334 DTRF 337 F Sbjct: 134 HMTF 137 >3TUP-A nrPDB Length = 415 Score = 30.8 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 8/19 (42%), Positives = 11/19 (57%) Query: 581 IALGLDRLICLVTGSPSIR 599 LGL+RL ++ P IR Sbjct: 276 FGLGLERLAMILYDIPDIR 294 Score = 30.8 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 24/69 (34%), Gaps = 6/69 (8%) Query: 229 PSREPGKFYSL------PQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQID 282 PSR+ G Y L + L+ GLD + V YR + P F Q++ Sbjct: 100 PSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLE 159 Query: 283 IEMSFVDQT 291 F Sbjct: 160 AVRLFSKHE 168 >6F8L-G nrPDB Length = 913 Score = 30.5 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 38/113 (33%), Gaps = 6/113 (5%) Query: 278 FTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRF 337 FT I IE ++Y P V P +TFA L + PD Sbjct: 656 FTTFSILKRIATPDKNTQTIEDPVEYEIPGINQTQVNPQAGLTFARALRAFLRQDPD--- 712 Query: 338 GMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGAKYLKRKDIESIRNF 390 II + ++ + +A H + + + A+ + R D + F Sbjct: 713 ---IIMVGEIRDSETAKIATEAALTGHLVIATLHTNDAAQAITRLDEMGVEPF 762 >1O5Q-A nrPDB Length = 305 Score = 30.5 bits (67), Expect = 2.7, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 24/89 (26%), Gaps = 12/89 (13%) Query: 205 HGFVDI-ETPTLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVAR 263 F D+ + P L T GA ++ P M ++ + V Sbjct: 199 RRFADVAQVPILANITEFGATPLFTTDELRSAHVAMALYP-LSAFRAMNRAAEKVYTVL- 256 Query: 264 CYRDEG-------SRPDRQPEFTQIDIEM 285 R EG R + I+ Sbjct: 257 --RQEGTQKNVIDIMQTRNELYESINYYQ 283 >2NUX-A nrPDB Length = 288 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 29/173 (16%), Positives = 58/173 (33%), Gaps = 27/173 (15%) Query: 383 DIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTA 442 ++++++ A + + I +F+N ++ L + ++ Sbjct: 18 NVDALKTHAKNLLEKGIDAIFVNGTTGLGPALSKDEKRQNLNALYDVTHK-----LIFQV 72 Query: 443 GEHNKACSLLGKLRLECADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENPRELESAHH 502 G N ++ ++ ++ ++ GV P F L FL K S+H Sbjct: 73 GSLNLN-DVMEL--VKFSNEMDILGVSSHSPYYFPRL----PEKFLAKYYEEIARISSHS 125 Query: 503 PFTAPHPS----DIHLL-----------YTEPKKARSQHYDLVLNGNEIGGGS 540 + +P+ DI T A S Y L L G ++ GS Sbjct: 126 LYIYNYPAATGYDIPPSILKSLPVKGIKDTNQDLAHSLEYKLNLPGVKVYNGS 178 >2ALY-A nrPDB Length = 266 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 14/34 (41%), Gaps = 6/34 (17%) Query: 572 DYGAPPHG------GIALGLDRLICLVTGSPSIR 599 G PP LG++RL L G P IR Sbjct: 216 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 249 >5AXK-A nrPDB Length = 251 Score = 30.1 bits (66), Expect = 3.4, Method: Composition-based stats. Identities = 27/170 (15%), Positives = 52/170 (30%), Gaps = 15/170 (8%) Query: 260 QVARCYRDEGSRPDRQPEFTQIDIEMSF-VDQTGIQSLIEGLLQYSWPNDKDPVVVPFPT 318 + R + + + E + + L K + P Sbjct: 12 CIPPVVLRADGRNFKNT-LSGLGFEKPYDKTFARAMADTAELF------IKKSGLSPLFA 64 Query: 319 MTFAEVLATYGTDKP-DTRF-GMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIPEGA 376 TF++ ++ TD P D R + + S + I + + A+ E Sbjct: 65 YTFSDEISFLFTDLPFDGRVEKIDSVVASFLGSALTIKLRLEEPIAFDSRLVALQKEEIP 124 Query: 377 KYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPVANFIMESQRLEL 426 +Y R+ +E+ RNF A N N A ++ + E+ Sbjct: 125 EYFHRRQLEAWRNFVASWGY----YALRNEGMGRNE-AAKYLKRKKESEI 169 >1PYS-A nrPDB Length = 350 Score = 29.7 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 14/34 (41%), Gaps = 6/34 (17%) Query: 572 DYGAPPHG------GIALGLDRLICLVTGSPSIR 599 G PP LG++RL L G P IR Sbjct: 300 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 333 >3QN3-A nrPDB Length = 417 Score = 29.3 bits (64), Expect = 5.6, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 20/50 (40%), Gaps = 1/50 (2%) Query: 365 GTVKAICIPEGAKYLKRKDIESIRNFAADHFNQEILPVFLNANRNWNSPV 414 G+V A +P GA ++ + +R+ + +L N N + Sbjct: 33 GSVGAAIVPSGASTGSKEAL-ELRDNDERFGGKGVLKAVANVNETIADEI 81 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.130 0.343 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,864,502 Number of Sequences: 36641 Number of extensions: 947512 Number of successful extensions: 2974 Number of sequences better than 10.0: 66 Number of HSP's better than 10.0 without gapping: 84 Number of HSP's successfully gapped in prelim test: 26 Number of HSP's that attempted gapping in prelim test: 2501 Number of HSP's gapped (non-prelim): 188 length of query: 645 length of database: 10,336,785 effective HSP length: 103 effective length of query: 542 effective length of database: 6,562,762 effective search space: 3557017004 effective search space used: 3557017004 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.5 bits)