BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q68FT9 (432 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3A9Z-A nrPDB 891 0.0 3GZD-A nrPDB 714 0.0 5WGB-A nrPDB 211 6e-55 5WT2-A nrPDB 201 4e-52 4EB7-A nrPDB 198 4e-51 3LVM-A nrPDB 194 8e-50 1ECX-A nrPDB 191 8e-49 4ISY-A nrPDB 181 7e-46 4W91-A nrPDB 102 4e-22 6C9E-A nrPDB 83 3e-16 5VPR-A nrPDB 82 6e-16 5XT5-A nrPDB 77 1e-14 1T3I-A nrPDB 71 7e-13 6MRE-A nrPDB 67 1e-11 4Q75-A nrPDB 66 3e-11 4LW2-A nrPDB 61 1e-09 5HH9-A nrPDB 55 5e-08 3CAI-A nrPDB 42 4e-04 3OP7-A nrPDB 36 0.031 2DR1-A nrPDB 35 0.081 5K1R-A nrPDB 32 0.36 3RPD-A nrPDB 31 1.3 5W25-A nrPDB 30 1.6 3TFJ-A nrPDB 30 2.0 3J0C-A nrPDB 30 2.3 2VSI-A nrPDB 30 2.8 1KL9-A nrPDB 29 3.2 6FEC-P nrPDB 29 4.9 6O9Z-L nrPDB 28 5.4 5XF9-D nrPDB 28 6.3 4M2J-A nrPDB 28 6.3 4QGR-A nrPDB 28 7.7 >3A9Z-A nrPDB Length = 432 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK 60 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK Sbjct: 1 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK 60 Query: 61 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE Sbjct: 61 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 Query: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT 180 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT Sbjct: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT 180 Query: 181 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF 240 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF Sbjct: 181 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF 240 Query: 241 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV 300 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV Sbjct: 241 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV 300 Query: 301 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV 360 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV Sbjct: 301 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV 360 Query: 361 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD 420 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD Sbjct: 361 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD 420 Query: 421 LKQAVNQLEGPV 432 LKQAVNQLEGPV Sbjct: 421 LKQAVNQLEGPV 432 >3GZD-A nrPDB Length = 440 Score = 714 bits (1843), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/415 (82%), Positives = 379/415 (91%), Gaps = 1/415 (0%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIG 75 P RKVYMDYNATTPLEPEVIQA+T+AM EAWGNPSS Y AGRKAKDIIN AR SLAKMIG Sbjct: 23 PERKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIG 82 Query: 76 GKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDS 135 GKPQDIIFTSGGTESNNLVIHS V+ FH QT +G T SP +G +PHFIT +VEHDS Sbjct: 83 GKPQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDS 142 Query: 136 IRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPIS 195 IRLPLEHLVE+QVA VTFVPVSKV+GQ EV+DILAAVRPTT LVTIMLANNETG++MP+ Sbjct: 143 IRLPLEHLVEEQVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVP 202 Query: 196 EISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGA 255 EIS+RIKALNQ R A+GLP +LVHTDAAQALGK+RVDVEDLGVDFLTIVGHKFYGPRIGA Sbjct: 203 EISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGA 262 Query: 256 LYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIR 315 LY+RG+G+ TPLYPMLFGGGQERNFRPGTENTPMIAGLGKAA+LV++NCE YEAHMRD+R Sbjct: 263 LYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVR 322 Query: 316 DYLEERLEAEFG-KRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGAS 374 DYLEERLEAEFG KRIHLNS+FPG +RLPNTCNFSI+G +L+G++VLAQC+ L+ASVGA+ Sbjct: 323 DYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASVGAA 382 Query: 375 CHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE 429 CHSDH D+PSPVLLS G+P DVARNA+RLSVGRSTTRAEVDL+VQDLKQAV QLE Sbjct: 383 CHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDLVVQDLKQAVAQLE 437 >5WGB-A nrPDB Length = 426 Score = 211 bits (536), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 148/429 (34%), Positives = 225/429 (52%), Gaps = 52/429 (12%) Query: 9 RGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSS-SYVAGRKAKDIINTAR 67 RGS R +YMD ATTPL+P V+ A+ + +GNP S ++ G +++ + AR Sbjct: 17 RGSHMLEMLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERAR 76 Query: 68 ASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFI 127 +A +IG P++IIFTSG TESNN+ I R + + + H I Sbjct: 77 QQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSR-----------------KKHLI 119 Query: 128 TCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNE 187 T EH + L E + +VT++PV K +G ++++++ AA++P T LV++M NNE Sbjct: 120 TTQTEHKCVLDSCRSL-EAEGFQVTYLPVQK-SGIIDLKELEAAIQPDTSLVSVMTVNNE 177 Query: 188 TGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHK 247 GV PI+EI R + +V HTDAAQA+GK +DV D+ +D ++I GHK Sbjct: 178 IGVKQPIAEIGRICSSR----------KVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHK 227 Query: 248 FYGPR-IGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCET 306 YGP+ +GA+Y+R ++ + + GGGQER R GT TP++ GLG A ++ + E Sbjct: 228 IYGPKGVGAIYIRRRPRVR-VEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEME- 285 Query: 307 YEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGV-------ERLPNTCNFSIQGSQLRGYM 359 Y+ H R + L ERL K + P V P N S + + G Sbjct: 286 YD-HKRISK--LSERLIQNIMKSL------PDVVMNGDPKHHYPGCINLSF--AYVEGES 334 Query: 360 VLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQ 419 +L + + S G++C S + PS VL + G D+A +++R +GR TT EVD V+ Sbjct: 335 LLMALKDVALSSGSACTSASLE-PSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVE 393 Query: 420 DLKQAVNQL 428 Q V +L Sbjct: 394 KCIQHVKRL 402 >5WT2-A nrPDB Length = 401 Score = 201 bits (512), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 147/420 (35%), Positives = 218/420 (51%), Gaps = 51/420 (12%) Query: 18 RKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGK 77 +++Y+D NATT ++P+V + + +++ +GNPSS + G + I A L K I + Sbjct: 3 QRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINAR 62 Query: 78 P-QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSI 136 D+I TS TESNN V L+G D+ + + H +T EH ++ Sbjct: 63 DIDDVIITSCATESNNWV-------------LKGVYFDECLKK--GKNHIVTTVAEHPAV 107 Query: 137 RLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISE 196 R L E EVT++P+++ +G + E + A+ T LV++M ANNETG+I PI E Sbjct: 108 RSTCNFL-ESLGVEVTYLPINE-HGSITAEQVREAITEKTALVSVMWANNETGLIFPIEE 165 Query: 197 ISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGA 255 I K VL HTDA QA+GK VDV DFL+ HKF+GP+ IG Sbjct: 166 IGAICKE----------KGVLFHTDAVQAIGKIPVDVLKANADFLSFSAHKFHGPKGIGG 215 Query: 256 LYVR-GVGKLTPLYPMLFGGGQERN-FRPGTENTPMIAGLGKAADLVSENCETYEAHMRD 313 LY+R GVG LTP LF GG+ N R GT N P I G+G+A L E+ + + + Sbjct: 216 LYIRSGVG-LTP----LFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGK 270 Query: 314 IRDYLEERL-----EAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLL 368 +RD LEE L G RIH R+PNT S++G + + + Sbjct: 271 LRDKLEEALLKIPDVMVVGDRIH---------RVPNTTLVSVRGIEGEAMLWDLNRSNIA 321 Query: 369 ASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 AS G++C S+ + +PV+++ G ++A A+RLS+ R T AE+D ++ QA +L Sbjct: 322 ASTGSACASE-DLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRL 380 >4EB7-A nrPDB Length = 382 Score = 198 bits (503), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 140/413 (33%), Positives = 218/413 (52%), Gaps = 47/413 (11%) Query: 21 YMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQD 80 Y DY + P++ +++A+ M E++GNPSS + G KA++ + AR +AK++ G Sbjct: 3 YFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGGT 62 Query: 81 IIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPL 140 ++FTSG TE+NNL I + + +G+ H + VEH S+ P Sbjct: 63 VVFTSGATEANNLAIIG----YAMRNARKGK-------------HILVSAVEHMSVINPA 105 Query: 141 EHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRR 200 + L + Q EV ++PV K G+V+V I +R T LV++ ANNE G I P+ EIS Sbjct: 106 KFL-QKQGFEVEYIPVGKY-GEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEV 163 Query: 201 IKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGALYVR 259 + + +H DA ++G+ VDVE +G D LTI + YGP+ +GAL++R Sbjct: 164 LAG-----------KAALHIDATASVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWIR 212 Query: 260 GVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVS-ENCETYEAHMRDIRDYL 318 K L P++ GGGQE R G+EN P I G GKAA++ + E E E R + Sbjct: 213 ---KEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITAMEWREEAERLRRLRDRII 269 Query: 319 EERLEAEFGKRIHLNSRFPGVERLPNTCN--FS-IQGSQLRGYMVLAQCQTLLASVGASC 375 + L+ E +LN +RLPN N FS I+G + + +A Q AS G++C Sbjct: 270 DNVLKIE---ESYLNGHPE--KRLPNNVNVRFSYIEGESIVLSLDMAGIQ---ASTGSAC 321 Query: 376 HSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 S +PS VL++CG+ + A + L++GR T +VD +++ L + +L Sbjct: 322 -SSKTLQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERL 373 >3LVM-A nrPDB Length = 423 Score = 194 bits (492), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 128/413 (30%), Positives = 221/413 (53%), Gaps = 41/413 (9%) Query: 20 VYMDYNATTPLEPEVIQAVTE--AMKEAWGNPSS-SYVAGRKAKDIINTARASLAKMIGG 76 +Y+DY+ATTP++P V + + + M +GNP+S S+ G +A++ ++ AR +A ++G Sbjct: 24 IYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGA 83 Query: 77 KPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSI 136 P++I+FTSG TES+NL I + ++ H IT EH ++ Sbjct: 84 DPREIVFTSGATESDNLAIKGAANFYQKKG-----------------KHIITSKTEHKAV 126 Query: 137 RLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISE 196 L +E + EVT++ + NG ++++++ AA+R T LV+IM NNE GV+ I+ Sbjct: 127 -LDTCRQLEREGFEVTYLAPQR-NGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAA 184 Query: 197 ISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGA 255 I +A ++ H DA Q++GK +D+ L VD ++ GHK YGP+ IGA Sbjct: 185 IGEMCRARG----------IIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGA 234 Query: 256 LYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIR 315 LYVR ++ + + GGG ER R GT I G+G+A + E T +R +R Sbjct: 235 LYVRRKPRVR-IEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLR 293 Query: 316 DYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASC 375 + L ++ + ++LN PN N S + + G ++ + L S G++C Sbjct: 294 NRLWNGIKDI--EEVYLNGDLE--HGAPNILNVSF--NYVEGESLIMALKDLAVSSGSAC 347 Query: 376 HSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 S + PS VL + G+ ++A +++R S+GR TT E+D ++ +++++ +L Sbjct: 348 TSASLE-PSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRL 399 >1ECX-A nrPDB Length = 384 Score = 191 bits (484), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 133/415 (32%), Positives = 214/415 (51%), Gaps = 43/415 (10%) Query: 19 KVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKP 78 +VY D NATT ++ V++ + +E +GNP+S++ G +A + AR +AK++G P Sbjct: 2 RVYFDNNATTRVDDRVLEEMIVFYREKYGNPNSAHGMGIEANLHMEKAREKVAKVLGVSP 61 Query: 79 QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRL 138 +I FTS TES N ++ + F +++ RT+ IT +EH ++ Sbjct: 62 SEIFFTSCATESINWILKTVAETFEKRK----RTI-------------ITTPIEHKAVLE 104 Query: 139 PLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEIS 198 +++L +V +VPV G V++E++ V T LV+IM ANNE G I P+ +++ Sbjct: 105 TMKYLSMKGF-KVKYVPVDS-RGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVT 162 Query: 199 RRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGALY 257 R +K N+ LVH DA Q +GK +E L VD+ + HKF+GP+ +G Y Sbjct: 163 RIVKKKNK--------ETLVHVDAVQTIGKIPFSLEKLEVDYASFSAHKFHGPKGVGITY 214 Query: 258 VRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDY 317 +R K P+ P++ GGGQER R GT+N P I G +A ++ E HM +R Sbjct: 215 IR---KGVPIRPLIHGGGQERGLRSGTQNVPGIVGAARAMEIAVEELSEAAKHMEKLRSK 271 Query: 318 LEERLEAEFGKRIHLNSRFPGVERLPNTCNFS---IQGSQLRGYMVLAQCQTLLASVGAS 374 L L G I P LPNT + S I+GS L+ L + S ++ Sbjct: 272 LVSGL-MNLGAHIIT----PLEISLPNTLSVSFPNIRGSTLQN---LLSGYGIYVSTSSA 323 Query: 375 CHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE 429 C S E R VL + G+ +A+ A+R+S+ + T EVD ++ +++ ++ L+ Sbjct: 324 CTSKDE-RLRHVLDAMGVDRRIAQGAIRISLCKYNTEEEVDYFLKKIEEILSFLD 377 >4ISY-A nrPDB Length = 404 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 131/416 (31%), Positives = 215/416 (51%), Gaps = 35/416 (8%) Query: 9 RGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARA 68 RGS + Y+D+ ATTP+ P I+A+ A++ GN SS + +GR A+ I AR Sbjct: 2 RGSHHHHHHGSAYLDHAATTPMHPAAIEAMA-AVQRTIGNASSLHTSGRSARRRIEEARE 60 Query: 69 SLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFIT 128 +A +G +P ++IFT+GGTES+NL + + E R +T Sbjct: 61 LIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDA--------------EPHRRRIVT 106 Query: 129 CTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRP--TTCLVTIMLANN 186 VEH ++ + LVE + A VT++P + +G V + A++ LV++M ANN Sbjct: 107 TEVEHHAVLDSVNWLVEHEGAHVTWLP-TAADGSVSATALREALQSHDDVALVSVMWANN 165 Query: 187 ETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGH 246 E G I+PI+E+S + G+P +H+DA QA+G+ +D G+ +++ GH Sbjct: 166 EVGTILPIAEMS-------VVAMEFGVP---MHSDAIQAVGQLPLDFGASGLSAMSVAGH 215 Query: 247 KFYG-PRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCE 305 KF G P +GAL +R + P++ GGGQER+ R GT + G+ AA + + E Sbjct: 216 KFGGPPGVGALLLR---RDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLE 272 Query: 306 TYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQ 365 A +R +RD L E + AE + P RL +F+ +G + ++L Sbjct: 273 ENSARLRLLRDRLVEGVLAEIDDVCLNGADDP--MRLAGNAHFTFRGCEGDALLMLLDAN 330 Query: 366 TLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDL 421 + S G++C + +PS VL++ G+ AR ++RLS+G ++ A+VD ++ L Sbjct: 331 GIECSTGSACTAG-VAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVL 385 >4W91-A nrPDB Length = 422 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 116/426 (27%), Positives = 170/426 (39%), Gaps = 70/426 (16%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMI-GGK 77 VY+D A+ VI AVT A + N + A D +R ++ + + G Sbjct: 41 VYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKSRETVRRFLNAGS 100 Query: 78 PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIR 137 +I+FT TE+ N V + P G + +EH S Sbjct: 101 VDEIVFTKNATEAINTVAYGYGM-----------------PFIGEGDEILLSIMEHHSNI 143 Query: 138 LPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEI 197 +P + E Q A++ F PV NG +E+ + T LV I +N G ++PI +I Sbjct: 144 VPWHFIRERQGAKLVFTPVDD-NGVFHIEEFEKRLSERTKLVAITHMSNTLGTVVPIKKI 202 Query: 198 SRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGAL 256 ++ A G+P VLV D +Q VDV+DLG D+ GHK YGP IG L Sbjct: 203 V-------ELAHARGIP-VLV--DGSQGAVHLPVDVQDLGCDWYVFTGHKVYGPSGIGVL 252 Query: 257 YVRG--VGKLTPLYPMLFGGGQ------ERN---------FRPGTENTPMIAGLGKAADL 299 Y R + K+ P GGG+ E N F GT GLG A + Sbjct: 253 YGRAQMLEKMRPFQ----GGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEY 308 Query: 300 VSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGY 358 + + AH D+RDY ERL RI N+ G +F+++G Sbjct: 309 MEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGA-----IISFALEGIHAHDV 363 Query: 359 MVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIV 418 ++ + G C P+L G+ + R S TRAEVD + Sbjct: 364 SMVIDRAGVAVRAGTHC-------AQPLLKRFGVT-----STCRASFALYNTRAEVDALA 411 Query: 419 QDLKQA 424 + L++A Sbjct: 412 EALEKA 417 >6C9E-A nrPDB Length = 422 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 112/429 (26%), Positives = 180/429 (41%), Gaps = 78/429 (18%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMIGGK- 77 VY D ATT VI A+ + ++ N + +A ++ ARA + + I + Sbjct: 41 VYFDNAATTQKPKAVIDAIAQFYEKDNSNVHRGVHALSVRATEMYEAARAKVKRFINARS 100 Query: 78 PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIR 137 P++ IF G TE+ NLV S V +I P+E + +EH S Sbjct: 101 PRECIFVRGTTEAINLVAQSLV-------------APRILPDE----EILITHMEHHSNI 143 Query: 138 LPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEI 197 +P + + + ++ P+S +NG+V +E+ + T +V I A+N G I P+ + Sbjct: 144 VPWQMVCKKMGCKLQVAPIS-LNGEVILEEFERKLNENTKMVAINYASNSLGTINPVKTM 202 Query: 198 SRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGAL 256 IK +++ A +VL+ D AQA VDV+DL DF GHK YGP IG L Sbjct: 203 ---IKMAHEVGA-----KVLL--DGAQATAHLIVDVQDLDCDFYAFSGHKMYGPTGIGVL 252 Query: 257 YVRG--VGKLTPLYPMLFGGGQERN---------------FRPGTENTPMIAGLGKAADL 299 + + + +TP GGG+ N F GT N GL A D Sbjct: 253 WGKEELLNSMTPYQ----GGGEMINSVSFEATEYAAIPHKFEAGTPNIAGAIGLAAAIDY 308 Query: 300 V-SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGY 358 + S + + + + +Y + +EA G I + N S + G Sbjct: 309 IWSLDLDAIAEYETQLLNYATKAIEAVKGYNI-----------IGTAANKVPIISFVHGK 357 Query: 359 MVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPV----DVARNAVRLSVGRSTTRAEV 414 + T+L S G + S H C +P+ DVA + R+S+ T E+ Sbjct: 358 IHAHDIGTILDSEGIAIRSGHH---------CTMPLMDFYDVAATS-RISMSFYNTFKEI 407 Query: 415 DLIVQDLKQ 423 D ++ L++ Sbjct: 408 DYCMEALQR 416 >5VPR-A nrPDB Length = 414 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 100/431 (23%), Positives = 178/431 (41%), Gaps = 71/431 (16%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMIGGK- 77 VY+D AT+ V+ A+ + N + + A +++ AR + + I K Sbjct: 32 VYLDNAATSQKPKMVLDAINNYYEHYNANVHRGIHTLSQVATEMMEDARKKVQRFINAKH 91 Query: 78 PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIR 137 +++FT G TE NLV ++ D I ++ I +EH S Sbjct: 92 DYEVLFTKGTTEGINLVAYAMT--------------DLIKKDD----EIIISYLEHHSNI 133 Query: 138 LPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEI 197 +P + L + A++ +P+++ +G ++++ + + T LV++ +N G++ PI EI Sbjct: 134 VPWQMLCQRTGAKLRVIPMNE-DGTLQIDVLDEWLSEKTKLVSVNQVSNALGIVNPIDEI 192 Query: 198 SRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGAL 256 R+++A + + D AQA +DV+ + DF GHK YGP G L Sbjct: 193 IRKVRAKSN---------AFIFIDGAQAAPHFEIDVQTMDCDFFAFSGHKMYGPTGTGIL 243 Query: 257 YVRG--VGKLTPLYPMLFGGGQ-------ERNFRPGT-----ENTPMIAG---LGKAADL 299 Y + + +L P + GGG+ E+ G TP IAG +G A D Sbjct: 244 YGKASVLEQLNPFH----GGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAIGTAVDF 299 Query: 300 VSE-NCETYEAHMRDIRDYLEER-LEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRG 357 + + AH + +Y + + LE E K + GV L G Sbjct: 300 MEKVGRSNIAAHEHALLEYAQRKLLEIEGLKVYGEKANRAGVVSF-----------NLSG 348 Query: 358 YMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLI 417 + + +L +G + + H P++ G+ VR S T E+D++ Sbjct: 349 IGIASDVGMILDKLGIAVRTGHH-CTQPIMEYFGVA-----GTVRASFAVYNTFEEIDIL 402 Query: 418 VQDLKQAVNQL 428 + +K+A L Sbjct: 403 TEGVKKAQKML 413 >5XT5-A nrPDB Length = 419 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/328 (26%), Positives = 139/328 (42%), Gaps = 61/328 (18%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-----YVAGRKAKDIINTARASLAKMI 74 VY+D +A T +P +AV E + + + +S+ + G +A D AR + K I Sbjct: 26 VYLD-SAATSQKP---RAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFI 81 Query: 75 GGKPQ-DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 K +IIFT G T S N+V S R + P + + +EH Sbjct: 82 NAKSMAEIIFTKGTTTSLNMVALSYARA-------------NLKPGD----EVVITYMEH 124 Query: 134 DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 + +P + V+ A + ++P+ + +G + +ED+ V T +V + +N G + P Sbjct: 125 HANIIPWQQAVKATGATLKYIPLQE-DGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNP 183 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 I E+++ I +G ++ D AQ+ ++DV+DL DF + HK GP Sbjct: 184 IKEMAK-------IAHDNG---AVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTG 233 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ--------------ERNFRPGTENTPMIA---GLGK 295 +G LY + L + P FGG F G TP+IA GLG Sbjct: 234 VGVLYGKK-ALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAG---TPIIAGAIGLGA 289 Query: 296 AADLVSE-NCETYEAHMRDIRDYLEERL 322 A D + E + H + Y ER Sbjct: 290 AIDFLEEIGLDEISRHEHKLAAYALERF 317 >1T3I-A nrPDB Length = 420 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 109/437 (24%), Positives = 178/437 (40%), Gaps = 87/437 (19%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGR-----KAKDIINTARASLAKMI 74 VY+D NA T +P +AV E + + N +++ G +A D R +AK I Sbjct: 30 VYLD-NAATSQKP---RAVLEKLMHYYENDNANVHRGAHQLSVRATDAYEAVRNKVAKFI 85 Query: 75 GGK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 + P++I++T TE+ NLV +S L+ D+I IT +EH Sbjct: 86 NARSPREIVYTRNATEAINLVAYSW-----GMNNLKAG--DEI----------ITTVMEH 128 Query: 134 DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 S +P + + A + FV + + ++E + T LVT++ +N G + P Sbjct: 129 HSNLVPWQMVAAKTGAVLKFVQLDE-QESFDLEHFKTLLSEKTKLVTVVHISNTLGCVNP 187 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 EI+ Q+ +G +VLV DA Q+ +DV+ + D+L GHK P Sbjct: 188 AEEIA-------QLAHQAG-AKVLV--DACQSAPHYPLDVQLIDCDWLVASGHKMCAPTG 237 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAA 297 IG LY G ++ P FGGG+ F GT LG A Sbjct: 238 IGFLY--GKEEILEAMPPFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAV 295 Query: 298 DLVS----ENCETYEAHMRDIRDYLEERLEAEFGK--RIHLNSRFPGVERLPNTCNFSIQ 351 D ++ EN YE ++ YL + L G+ ++ L P +F++ Sbjct: 296 DYLTDLGMENIHNYEV---ELTHYLWQGL----GQIPQLRLYGPNPKHGDRAALASFNVA 348 Query: 352 GSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDV---ARNAVRLSVGRS 408 G + + T++ G + S H C P+ A + R S+ Sbjct: 349 G------LHASDVATMVDQDGIAIRSGHH---------CTQPLHRLFDASGSARASLYFY 393 Query: 409 TTRAEVDLIVQDLKQAV 425 T+ E+DL +Q L+ + Sbjct: 394 NTKEEIDLFLQSLQATI 410 >6MRE-A nrPDB Length = 420 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 134/327 (40%), Gaps = 56/327 (17%) Query: 21 YMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMIGGK-P 78 Y+D A+ +VI A E + + + +A + + R + I + Sbjct: 40 YLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQATEKMENVRKRASLFINARSA 99 Query: 79 QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRL 138 ++++F +G TE NLV +S R D I I +EH + + Sbjct: 100 EELVFVAGTTEGINLVANSWGNS-------NVRAGDNI----------IISQMEHHANIV 142 Query: 139 PLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEIS 198 P + L AE+ +P++ +G +++E + T L+ I +N G P++E+ Sbjct: 143 PWQMLCARVGAELRVIPLNP-DGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEM- 200 Query: 199 RRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGALY 257 I +Q A +VLV D AQA+ VDV+ L DF GHK YGP IG LY Sbjct: 201 --ITLAHQHGA-----KVLV--DGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILY 251 Query: 258 VRGVGKLTPLYPMLFGGGQ----------------ERNFRPGTENTPMIAGLGKAADLVS 301 V+ L P GGG F GT NT I GLG A + VS Sbjct: 252 VKEA--LLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVS 309 Query: 302 ----ENCETYEAHMRDIRDYLEERLEA 324 N YE +++ Y +LE+ Sbjct: 310 ALGLNNIAEYE---QNLMHYALSQLES 333 >4Q75-A nrPDB Length = 429 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 94/362 (25%), Positives = 147/362 (40%), Gaps = 64/362 (17%) Query: 17 NRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-----YVAGRKAKDIINTARASLA 71 ++ VY+D +A T +P AV +A++ + +S+ + KA D AR +A Sbjct: 37 SKLVYLD-SAATSQKP---AAVLDALQNYYEFYNSNVHRGIHYLSAKATDEFELARKKVA 92 Query: 72 KMIGGK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCT 130 + I ++I+FT TE+ NLV +S + + P + I Sbjct: 93 RFINASDSREIVFTRNATEAINLVAYS-------------WGLSNLKPGDEV----ILTV 135 Query: 131 VEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGV 190 EH S +P + + + A + FV +++ + ++ + + P T LV + +N Sbjct: 136 AEHHSCIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAVHHVSNVLAS 194 Query: 191 IMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYG 250 +PI EI + A +VLV DA Q++ VDV+ L DFL HK G Sbjct: 195 SLPIEEIV--------VWAHDVGAKVLV--DACQSVPHMVVDVQKLNADFLVASSHKMCG 244 Query: 251 PR-IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLG 294 P IG LY G L P GGG+ F GT LG Sbjct: 245 PTGIGFLY--GKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALG 302 Query: 295 KAADLVS----ENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSI 350 A D +S YE +I YL E+L + RI+ V R C+F++ Sbjct: 303 AAVDYLSGIGMPKIHEYEV---EIGKYLYEKLSSLPDVRIYGPRPSESVHR-GALCSFNV 358 Query: 351 QG 352 +G Sbjct: 359 EG 360 >4LW2-A nrPDB Length = 404 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 106/436 (24%), Positives = 180/436 (41%), Gaps = 84/436 (19%) Query: 20 VYMDYNATTPLEPE-VIQAVTEAMKEAWGN-PSSSYVAGRKAKDIINTARASLAKMIGGK 77 VY+D +A T L+PE V++A + + GN S + ++ AR +A+++ Sbjct: 24 VYLD-SAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNA- 81 Query: 78 PQD--IIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDS 135 P D I++T G TES N+V +C+ + G D+I I EH + Sbjct: 82 PDDKTIVWTRGTTESINMV----AQCYARPRLQPG---DEI----------IVSVAEHHA 124 Query: 136 IRLPLEHLVEDQVAEVTFVPVSKVNGQ--VEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 +P + + A+V +P+ N Q +V+ + + P + ++ + +N TG Sbjct: 125 NLVPWLMVAQQTGAKVVKLPL---NAQRLPDVDLLPELITPRSRILALGQMSNVTG---G 178 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 +++R I ++G+ +V D AQ DV+ L +DF GHK YGP Sbjct: 179 CPDLARAIT----FAHSAGM---VVMVDGAQGAVHFPADVQQLDIDFYAFSGHKLYGPTG 231 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ---ERNF------------RPGTENTPMIAGLGKAA 297 IG LY G +L GGG+ E +F GT N + GL A Sbjct: 232 IGVLY--GKSELLEAMSPWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAAL 289 Query: 298 DLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLR 356 + +++ + E+ R + E+ L KR P +F Q S L Sbjct: 290 EWLADYDINQAESWSRSLATLAEDAL----AKR-------------PGFRSFRCQDSSLL 332 Query: 357 GYMVL----AQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRA 412 + + TLLA G + + + P+L G+ +R S T++ Sbjct: 333 AFDFAGVHHSDMVTLLAEYGIALRAG-QHCAQPLLAELGV-----TGTLRASFAPYNTKS 386 Query: 413 EVDLIVQDLKQAVNQL 428 +VD +V + +A+ L Sbjct: 387 DVDALVNAVDRALELL 402 >5HH9-A nrPDB Length = 390 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 23/237 (9%) Query: 105 QQTLQGRTVDQISPEEG---TRP--HFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKV 159 Q L G T D ++ G +P +T + EH S LE+ + +V P+ K Sbjct: 78 QVALTGSTTDGLAAIYGGLLVQPGKEILTSSHEHYSTYTTLEYRHKRMGTQVREFPLFKD 137 Query: 160 NGQVEVEDIL----AAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPR 215 +V ++IL A +RP T ++ + + +GV +PI EI + ++ LNQ R R Sbjct: 138 PHRVSADEILSSIAAQIRPQTRVLGMTWVQSGSGVKLPIREIGKLVRELNQKRDEQD--R 195 Query: 216 VLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKF-YGPR-IGALYVRGVGKLTPLYPMLFG 273 ++ D G V D D+ HK+ +GPR G + R L P + Sbjct: 196 IIYVVDGVHGFGVEDVSFADFDCDYFIAGTHKWLFGPRGTGVIIARSEQLQEHLVPSIPT 255 Query: 274 GGQERNFRPGTENTP-------MIAGLGKAADL-VSENCETYEAHMRDIRDYLEERL 322 + NF GT TP LG A +L + +A + + YL++RL Sbjct: 256 FSRADNF--GTLMTPGGYHAFEHRLALGTAFELHLQLGKAEVQARIHQLNAYLKQRL 310 >3CAI-A nrPDB Length = 406 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/258 (18%), Positives = 104/258 (40%), Gaps = 30/258 (11%) Query: 2 DVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKD 61 DVAR RG S + V+ D A + V V+ A + + + ++ + R++ Sbjct: 12 DVAR--VRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTVGAHPSARRSAA 69 Query: 62 IINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEG 121 +++ AR ++A ++ P ++ + ++ L + S G Sbjct: 70 VLDAAREAVADLVNADPGGVVLGA------------------DRAVLLSLLAEASSSRAG 111 Query: 122 TRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTI 181 I ++ ++ P A+V + V G++ + + +T LV + Sbjct: 112 LGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRLVAV 171 Query: 182 MLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFL 241 N+ +G + ++++ K ++ + A LV D + A R +D+ + D + Sbjct: 172 ---NSASGTLGGVTDLRAMTKLVHDVGA-------LVVVDHSAAAPYRLLDIRETDADVV 221 Query: 242 TIVGHKFYGPRIGALYVR 259 T+ H + GP IGA+ R Sbjct: 222 TVNAHAWGGPPIGAMVFR 239 >3OP7-A nrPDB Length = 375 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 68/145 (46%), Gaps = 27/145 (18%) Query: 67 RASLAKMIGG-KPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPH 125 + S++++ G KP+ I+ T+G T +N LV++S + E G H Sbjct: 69 KKSVSQLYTGVKPEQILQTNGATGANLLVLYSLI-------------------EPGD--H 107 Query: 126 FITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQV-EVEDILAAVRPTTCLVTIMLA 184 I+ + L + + AEV + + NG + ++E + +RPTT ++ I A Sbjct: 108 VISLYPTYQQ----LYDIPKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICINNA 163 Query: 185 NNETGVIMPISEISRRIKALNQIRA 209 NN TG +M + + ++ +++ A Sbjct: 164 NNPTGAVMDRTYLEELVEIASEVGA 188 >2DR1-A nrPDB Length = 386 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 71/181 (39%), Gaps = 36/181 (19%) Query: 163 VEVEDILAAVR--PTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHT 220 V+ ED+ A+R P VTI TGV+ P+ E+++ K ++ LV Sbjct: 132 VKPEDLDDALRKNPDVEAVTITYNETSTGVLNPLPELAKVAKEHDK----------LVFV 181 Query: 221 DAAQALGKRRVDVEDLGVDFLTIVGHKFYGP----RIGALY-----------VRGVGKLT 265 DA A+G + + G+D + K +G IGA RG Sbjct: 182 DAVSAMGGADIKFDKWGLDVVFSSSQKAFGVPPGLAIGAFSERFLEIAEKMPERGWYFDI 241 Query: 266 PLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV------SENCETYEAHMRDIRDYLE 319 PLY +E+ P T P + G+ A ++ + E YE + +R+ + Sbjct: 242 PLYVKYL---KEKESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKRAKMVREGVR 298 Query: 320 E 320 E Sbjct: 299 E 299 >5K1R-A nrPDB Length = 480 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 27/147 (18%) Query: 123 RPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIM 182 RP I H + R HL +VT P+ V QV+ + + AV T ++ Sbjct: 149 RPRMIWPASAHPAFR-KAAHLFG---FDVTVAPIDPVTMQVDADFVRDAVDANTVMLVGS 204 Query: 183 LANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDA---------AQALGKRRVDV 233 N G I PI +S A + V +H D +ALG + Sbjct: 205 ACNYPYGTIDPIGALS----------AIAVEKDVWLHVDGCLGGWMLPWGEALGYPDIPA 254 Query: 234 EDL---GVDFLTIVGHKF-YGPRIGAL 256 D GV ++ HKF YGP+ G++ Sbjct: 255 FDFRLPGVTSISADTHKFGYGPKGGSV 281 >3RPD-A nrPDB Length = 357 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 2/38 (5%) Query: 96 HSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 H +R + Q L G +D +S E TR HF+T +EH Sbjct: 54 HDALRLSLQDQQLAG--IDIVSDGEQTRQHFVTTFIEH 89 >5W25-A nrPDB Length = 616 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 22/47 (46%) Query: 54 VAGRKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVR 100 + G AK++ R LA +G KP D IF S G ++ + R Sbjct: 378 LGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAAR 424 >3TFJ-A nrPDB Length = 369 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 7/70 (10%) Query: 224 QALGKRRVDVEDLGVDFLTIVGHKFYGPRIGA-------LYVRGVGKLTPLYPMLFGGGQ 276 + GK+ +++ G D+ G K R G +YV LY LF G+ Sbjct: 166 KVFGKKITELKFFGFDYFDFEGTKHLIARSGWSKQGGYEVYVENTQSGQKLYDHLFEVGK 225 Query: 277 ERNFRPGTEN 286 E N PG N Sbjct: 226 EFNVGPGCPN 235 >3J0C-A nrPDB Length = 442 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 31/56 (55%), Gaps = 4/56 (7%) Query: 264 LTPLYPMLFGGGQERNFRPGTENTPMI-AGLGKAADLVSENCETYEAHMRDIRDYL 318 T +YP ++GG TENT + A + K+ D ++++ E Y+AH ++ +L Sbjct: 81 FTGVYPFMWGGAYCFC---DTENTQVSKAYVMKSDDCLADHAEAYKAHTASVQAFL 133 >2VSI-A nrPDB Length = 236 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 42/102 (41%), Gaps = 4/102 (3%) Query: 61 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 D ++ A + K + + II T GG + N I + + + L D + + Sbjct: 57 DWVSHAEDLVDKYLPLYKERIIITKGGADRNT-SIKNIIEAIDAYRPLTPE--DIVVTHD 113 Query: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQ 162 RP FIT + D+I+L H D V E V NGQ Sbjct: 114 SVRP-FITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQ 154 >1KL9-A nrPDB Length = 182 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 45/81 (55%), Gaps = 10/81 (12%) Query: 164 EVEDILA----AVRPTTCLVTIMLANNETGVIMPISEISRR-IKALNQ-IRAASGLPRVL 217 EVED++ ++ V+++ NN G+I+ +SE+SRR I+++N+ IR V+ Sbjct: 14 EVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMIL-LSELSRRRIRSINKLIRIGRNECVVV 72 Query: 218 VHTDAAQA---LGKRRVDVED 235 + D + L KRRV E+ Sbjct: 73 IRVDKEKGYIDLSKRRVSPEE 93 >6FEC-P nrPDB Length = 266 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 45/81 (55%), Gaps = 10/81 (12%) Query: 164 EVEDILA----AVRPTTCLVTIMLANNETGVIMPISEISRR-IKALNQ-IRAASGLPRVL 217 EVED++ ++ V+++ NN G+I+ +SE+SRR I+++N+ IR V+ Sbjct: 10 EVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMIL-LSELSRRRIRSINKLIRIGRNECVVV 68 Query: 218 VHTDAAQA---LGKRRVDVED 235 + D + L KRRV E+ Sbjct: 69 IRVDKEKGYIDLSKRRVSPEE 89 >6O9Z-L nrPDB Length = 323 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 45/81 (55%), Gaps = 10/81 (12%) Query: 164 EVEDILA----AVRPTTCLVTIMLANNETGVIMPISEISRR-IKALNQ-IRAASGLPRVL 217 EVED++ ++ V+++ NN G+I+ +SE+SRR I+++N+ IR V+ Sbjct: 23 EVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMIL-LSELSRRRIRSINKLIRIGRNECVVV 81 Query: 218 VHTDAAQA---LGKRRVDVED 235 + D + L KRRV E+ Sbjct: 82 IRVDKEKGYIDLSKRRVSPEE 102 >5XF9-D nrPDB Length = 468 Score = 28.5 bits (62), Expect = 6.3, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 7/53 (13%) Query: 293 LGKAADLVSENCETYEAHMRD-------IRDYLEERLEAEFGKRIHLNSRFPG 338 LG +AD N A R+ +R + +E +EA GKRIH S PG Sbjct: 138 LGFSADPAQRNVFGLAAQKRELARQGILVRQFGQECIEATAGKRIHGTSAVPG 190 >4M2J-A nrPDB Length = 406 Score = 28.5 bits (62), Expect = 6.3, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 48/110 (43%), Gaps = 7/110 (6%) Query: 131 VEHDSIRLPLEHLVEDQVAEVTFVPVSKV-NGQVEVEDILAAVRPTTCLVTIMLANNETG 189 V + I L H +V +P V +G+++ + + V P T V + +N TG Sbjct: 130 VVQEGIYHSLGHYPRAAGCDVAVLPGRAVRDGEIDPDVLAGLVTPGTAAVIVNFPHNPTG 189 Query: 190 VIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVD 239 V + + ++AL + AA+G VLV A + R + D G D Sbjct: 190 VTLS----PQGLRALKERTAATGA--VLVWDAATAEIAHRWEVLADPGAD 233 >4QGR-A nrPDB Length = 382 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 31/127 (24%), Positives = 52/127 (40%), Gaps = 21/127 (16%) Query: 125 HFITCTVEHDSIRLPLE-------HLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTT- 176 H I C D++++PL H V V TF ++V V E + V P + Sbjct: 59 HVIACANGTDALQMPLMTRGIGPGHAV--FVPSFTFAATAEVVALVGAEPVFVDVDPDSY 116 Query: 177 ----------CLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQAL 226 TI E I+P+ ++ + N+I A + + + DAAQ++ Sbjct: 117 NMNVEQLEAAIAATIKEGRLEPKAIIPV-DLFGLAASYNRITAIAEREGLFIIEDAAQSI 175 Query: 227 GKRRVDV 233 G +R +V Sbjct: 176 GGKRDNV 182 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3A9Z-A nrPDB 566 e-162 3GZD-A nrPDB 514 e-146 5WGB-A nrPDB 405 e-113 1ECX-A nrPDB 391 e-109 3LVM-A nrPDB 390 e-108 5WT2-A nrPDB 373 e-104 5VPR-A nrPDB 359 1e-99 1T3I-A nrPDB 356 1e-98 4EB7-A nrPDB 354 4e-98 4W91-A nrPDB 353 8e-98 4ISY-A nrPDB 341 4e-94 5XT5-A nrPDB 337 6e-93 6C9E-A nrPDB 337 7e-93 4Q75-A nrPDB 336 1e-92 6MRE-A nrPDB 324 3e-89 4LW2-A nrPDB 317 6e-87 3CAI-A nrPDB 223 1e-58 5HH9-A nrPDB 198 4e-51 Sequences not found previously or not previously below threshold: 1QZ9-A nrPDB 75 5e-14 5V1X-E nrPDB 65 8e-11 2DR1-A nrPDB 63 2e-10 4Q6R-A nrPDB 63 2e-10 2BKW-A nrPDB 61 9e-10 5DX5-A nrPDB 60 2e-09 3ZRR-A nrPDB 59 3e-09 1VJO-A nrPDB 56 4e-08 1XI9-A nrPDB 56 4e-08 2E7J-A nrPDB 54 1e-07 5K1R-A nrPDB 54 1e-07 3OP7-A nrPDB 53 2e-07 5GP4-C nrPDB 53 2e-07 1V2E-A nrPDB 53 2e-07 4W8I-A nrPDB 53 4e-07 2YRI-A nrPDB 51 1e-06 1M32-A nrPDB 49 4e-06 5O5C-A nrPDB 47 1e-05 3F9T-A nrPDB 46 4e-05 5LUC-A nrPDB 45 6e-05 1IBJ-A nrPDB 44 1e-04 3DR4-A nrPDB 44 2e-04 3FFH-A nrPDB 43 2e-04 1N8P-A nrPDB 43 3e-04 1O4S-A nrPDB 43 3e-04 1J32-A nrPDB 43 3e-04 3WKR-A nrPDB 42 4e-04 2Z9W-A nrPDB 42 5e-04 2E54-A nrPDB 41 0.001 4CVQ-A nrPDB 41 0.001 3QI6-A nrPDB 40 0.002 1U08-A nrPDB 39 0.004 2GB3-A nrPDB 39 0.005 3FFR-A nrPDB 38 0.006 2DGM-A nrPDB 36 0.024 6F35-A nrPDB 36 0.036 1GC4-A nrPDB 35 0.049 5HSI-A nrPDB 35 0.054 3NYS-A nrPDB 35 0.058 4ZWV-A nrPDB 34 0.089 3VOM-A nrPDB 34 0.094 2O0R-A nrPDB 34 0.097 2CY8-A nrPDB 34 0.14 1PFF-A nrPDB 33 0.24 4PIW-A nrPDB 32 0.49 6BLG-A nrPDB 32 0.58 4BMK-A nrPDB 32 0.62 5K8B-A nrPDB 32 0.65 3TEJ-A nrPDB 31 1.1 1ZEJ-A nrPDB 31 1.1 1MDZ-A nrPDB 31 1.3 6FYQ-A nrPDB 31 1.3 2VUU-A nrPDB 31 1.4 2QMA-A nrPDB 31 1.5 4OTL-A nrPDB 30 1.5 5WSC-A nrPDB 30 1.6 3NRA-A nrPDB 30 1.6 1ZKI-A nrPDB 30 1.7 1VCN-A nrPDB 30 1.7 2BKA-A nrPDB 30 1.9 2FMU-A nrPDB 30 2.2 5VMK-A nrPDB 29 2.8 6F77-B nrPDB 29 2.9 4EVZ-A nrPDB 28 6.4 5W25-A nrPDB 28 6.7 5DDW-A nrPDB 28 7.6 1YQG-A nrPDB 28 8.8 3MEN-A nrPDB 28 9.4 5C2Z-A nrPDB 28 10.0 >3A9Z-A nrPDB Length = 432 Score = 566 bits (1457), Expect = e-162, Method: Composition-based stats. Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK 60 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK Sbjct: 1 MDVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAK 60 Query: 61 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE Sbjct: 61 DIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 Query: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT 180 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT Sbjct: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVT 180 Query: 181 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF 240 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF Sbjct: 181 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF 240 Query: 241 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV 300 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV Sbjct: 241 LTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLV 300 Query: 301 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV 360 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV Sbjct: 301 SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMV 360 Query: 361 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD 420 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD Sbjct: 361 LAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQD 420 Query: 421 LKQAVNQLEGPV 432 LKQAVNQLEGPV Sbjct: 421 LKQAVNQLEGPV 432 >3GZD-A nrPDB Length = 440 Score = 514 bits (1323), Expect = e-146, Method: Composition-based stats. Identities = 341/418 (81%), Positives = 380/418 (90%), Gaps = 1/418 (0%) Query: 13 ESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAK 72 + P RKVYMDYNATTPLEPEVIQA+T+AM EAWGNPSS Y AGRKAKDIIN AR SLAK Sbjct: 20 HNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAK 79 Query: 73 MIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVE 132 MIGGKPQDIIFTSGGTESNNLVIHS V+ FH QT +G T SP +G +PHFIT +VE Sbjct: 80 MIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVE 139 Query: 133 HDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIM 192 HDSIRLPLEHLVE+QVA VTFVPVSKV+GQ EV+DILAAVRPTT LVTIMLANNETG++M Sbjct: 140 HDSIRLPLEHLVEEQVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVM 199 Query: 193 PISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR 252 P+ EIS+RIKALNQ R A+GLP +LVHTDAAQALGK+RVDVEDLGVDFLTIVGHKFYGPR Sbjct: 200 PVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR 259 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMR 312 IGALY+RG+G+ TPLYPMLFGGGQERNFRPGTENTPMIAGLGKAA+LV++NCE YEAHMR Sbjct: 260 IGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMR 319 Query: 313 DIRDYLEERLEAEFG-KRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASV 371 D+RDYLEERLEAEFG KRIHLNS+FPG +RLPNTCNFSI+G +L+G++VLAQC+ L+ASV Sbjct: 320 DVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASV 379 Query: 372 GASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE 429 GA+CHSDH D+PSPVLLS G+P DVARNA+RLSVGRSTTRAEVDL+VQDLKQAV QLE Sbjct: 380 GAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDLVVQDLKQAVAQLE 437 >5WGB-A nrPDB Length = 426 Score = 405 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 139/422 (32%), Positives = 218/422 (51%), Gaps = 38/422 (9%) Query: 9 RGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSS-SYVAGRKAKDIINTAR 67 RGS R +YMD ATTPL+P V+ A+ + +GNP S ++ G +++ + AR Sbjct: 17 RGSHMLEMLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERAR 76 Query: 68 ASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFI 127 +A +IG P++IIFTSG TESNN+ I R + + + H I Sbjct: 77 QQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSR-----------------KKHLI 119 Query: 128 TCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNE 187 T EH + L E + +VT++PV K +G ++++++ AA++P T LV++M NNE Sbjct: 120 TTQTEHKCVLDSCRSL-EAEGFQVTYLPVQK-SGIIDLKELEAAIQPDTSLVSVMTVNNE 177 Query: 188 TGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHK 247 GV PI+EI R + +V HTDAAQA+GK +DV D+ +D ++I GHK Sbjct: 178 IGVKQPIAEIGRICSSR----------KVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHK 227 Query: 248 FYGPR-IGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCET 306 YGP+ +GA+Y+R ++ + + GGGQER R GT TP++ GLG A ++ + E Sbjct: 228 IYGPKGVGAIYIRRRPRVR-VEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEY 286 Query: 307 YEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQT 366 + + + L + + + P N S + + G +L + Sbjct: 287 DHKRISKLSERLIQNIMKSLPDVVMNGDPK---HHYPGCINLSF--AYVEGESLLMALKD 341 Query: 367 LLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVN 426 + S G++C S PS VL + G D+A +++R +GR TT EVD V+ Q V Sbjct: 342 VALSSGSACTSAS-LEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIQHVK 400 Query: 427 QL 428 +L Sbjct: 401 RL 402 >1ECX-A nrPDB Length = 384 Score = 391 bits (1003), Expect = e-109, Method: Composition-based stats. Identities = 126/412 (30%), Positives = 207/412 (50%), Gaps = 37/412 (8%) Query: 19 KVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKP 78 +VY D NATT ++ V++ + +E +GNP+S++ G +A + AR +AK++G P Sbjct: 2 RVYFDNNATTRVDDRVLEEMIVFYREKYGNPNSAHGMGIEANLHMEKAREKVAKVLGVSP 61 Query: 79 QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRL 138 +I FTS TES N ++ + F ++ + IT +EH ++ Sbjct: 62 SEIFFTSCATESINWILKTVAETFEKR-----------------KRTIITTPIEHKAVLE 104 Query: 139 PLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEIS 198 +++L +V +VPV G V++E++ V T LV+IM ANNE G I P+ +++ Sbjct: 105 TMKYLSMK-GFKVKYVPVDS-RGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVT 162 Query: 199 RRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGALY 257 R +K N+ LVH DA Q +GK +E L VD+ + HKF+GP+ +G Y Sbjct: 163 RIVKKKNK--------ETLVHVDAVQTIGKIPFSLEKLEVDYASFSAHKFHGPKGVGITY 214 Query: 258 VRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDY 317 +R K P+ P++ GGGQER R GT+N P I G +A ++ E HM +R Sbjct: 215 IR---KGVPIRPLIHGGGQERGLRSGTQNVPGIVGAARAMEIAVEELSEAAKHMEKLRSK 271 Query: 318 LEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHS 377 L L G I P LPNT + S + L + S ++C S Sbjct: 272 LVSGL-MNLGAHIIT----PLEISLPNTLSVSFPNIRGSTLQNLLSGYGIYVSTSSACTS 326 Query: 378 DHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE 429 ++R VL + G+ +A+ A+R+S+ + T EVD ++ +++ ++ L+ Sbjct: 327 -KDERLRHVLDAMGVDRRIAQGAIRISLCKYNTEEEVDYFLKKIEEILSFLD 377 >3LVM-A nrPDB Length = 423 Score = 390 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 128/414 (30%), Positives = 218/414 (52%), Gaps = 41/414 (9%) Query: 19 KVYMDYNATTPLEPEVIQAVTEAM--KEAWGNP-SSSYVAGRKAKDIINTARASLAKMIG 75 +Y+DY+ATTP++P V + + + M +GNP S S+ G +A++ ++ AR +A ++G Sbjct: 23 PIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVG 82 Query: 76 GKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDS 135 P++I+FTSG TES+NL I + ++ H IT EH + Sbjct: 83 ADPREIVFTSGATESDNLAIKGAANFYQKK-----------------GKHIITSKTEHKA 125 Query: 136 IRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPIS 195 + L E + EVT++ + NG ++++++ AA+R T LV+IM NNE GV+ I+ Sbjct: 126 VLDTCRQL-EREGFEVTYLAPQR-NGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIA 183 Query: 196 EISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IG 254 I +A ++ H DA Q++GK +D+ L VD ++ GHK YGP+ IG Sbjct: 184 AIGEMCRARG----------IIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIG 233 Query: 255 ALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDI 314 ALYVR ++ + + GGG ER R GT I G+G+A + E T +R + Sbjct: 234 ALYVRRKPRVR-IEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGL 292 Query: 315 RDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGAS 374 R+ L ++ + ++LN PN N S + + G ++ + L S G++ Sbjct: 293 RNRLWNGIKDI--EEVYLNGDLE--HGAPNILNVSF--NYVEGESLIMALKDLAVSSGSA 346 Query: 375 CHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 C S PS VL + G+ ++A +++R S+GR TT E+D ++ +++++ +L Sbjct: 347 CTSAS-LEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRL 399 >5WT2-A nrPDB Length = 401 Score = 373 bits (958), Expect = e-104, Method: Composition-based stats. Identities = 135/415 (32%), Positives = 208/415 (50%), Gaps = 37/415 (8%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIG 75 +++Y+D NATT ++P+V + + +++ +GNPSS + G + I A L K I Sbjct: 1 MVQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGIN 60 Query: 76 GKP-QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHD 134 + D+I TS TESNN V+ D+ + + H +T EH Sbjct: 61 ARDIDDVIITSCATESNNWVLKGVY-------------FDECLKK--GKNHIVTTVAEHP 105 Query: 135 SIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPI 194 ++R L E EVT++P+++ +G + E + A+ T LV++M ANNETG+I PI Sbjct: 106 AVRSTCNFL-ESLGVEVTYLPINE-HGSITAEQVREAITEKTALVSVMWANNETGLIFPI 163 Query: 195 SEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-I 253 EI K VL HTDA QA+GK VDV DFL+ HKF+GP+ I Sbjct: 164 EEIGAICKEKG----------VLFHTDAVQAIGKIPVDVLKANADFLSFSAHKFHGPKGI 213 Query: 254 GALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRD 313 G LY+R LT P+ GG R GT N P I G+G+A L E+ + + + Sbjct: 214 GGLYIRSGVGLT---PLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGK 270 Query: 314 IRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGA 373 +RD LEE L + + + R+PNT S++G + + + AS G+ Sbjct: 271 LRDKLEEALLKIPDVMVVGDR----IHRVPNTTLVSVRGIEGEAMLWDLNRSNIAASTGS 326 Query: 374 SCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 +C S+ +PV+++ G ++A A+RLS+ R T AE+D ++ QA +L Sbjct: 327 ACASED-LEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRL 380 >5VPR-A nrPDB Length = 414 Score = 359 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 93/432 (21%), Positives = 171/432 (39%), Gaps = 65/432 (15%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMI 74 VY+D AT+ V+ A+ + N + + A +++ AR + + I Sbjct: 28 GKDLVYLDNAATSQKPKMVLDAINNYYEHYNANVHRGIHTLSQVATEMMEDARKKVQRFI 87 Query: 75 GGK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 K +++FT G TE NLV ++ D I ++ I +EH Sbjct: 88 NAKHDYEVLFTKGTTEGINLVAYAM--------------TDLIKKDD----EIIISYLEH 129 Query: 134 DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 S +P + L + A++ +P+++ +G ++++ + + T LV++ +N G++ P Sbjct: 130 HSNIVPWQMLCQRTGAKLRVIPMNE-DGTLQIDVLDEWLSEKTKLVSVNQVSNALGIVNP 188 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 I EI R+++A + + D AQA +DV+ + DF GHK YGP Sbjct: 189 IDEIIRKVRAKSN---------AFIFIDGAQAAPHFEIDVQTMDCDFFAFSGHKMYGPTG 239 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAA 297 G LY G + GGG+ F GT N +G A Sbjct: 240 TGILY--GKASVLEQLNPFHGGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAIGTAV 297 Query: 298 DLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLR 356 D + + AH + +Y + +L G +++ +F+ L Sbjct: 298 DFMEKVGRSNIAAHEHALLEYAQRKLLEIEGLKVYGEKAN-----RAGVVSFN-----LS 347 Query: 357 GYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDL 416 G + + +L +G + + H P++ G+ VR S T E+D+ Sbjct: 348 GIGIASDVGMILDKLGIAVRTGHH-CTQPIMEYFGVA-----GTVRASFAVYNTFEEIDI 401 Query: 417 IVQDLKQAVNQL 428 + + +K+A L Sbjct: 402 LTEGVKKAQKML 413 >1T3I-A nrPDB Length = 420 Score = 356 bits (913), Expect = 1e-98, Method: Composition-based stats. Identities = 94/432 (21%), Positives = 162/432 (37%), Gaps = 63/432 (14%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMI 74 + VY+D AT+ V++ + + N + +A D R +AK I Sbjct: 26 GHPLVYLDNAATSQKPRAVLEKLMHYYENDNANVHRGAHQLSVRATDAYEAVRNKVAKFI 85 Query: 75 GGK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 + P++I++T TE+ NLV +S + IT +EH Sbjct: 86 NARSPREIVYTRNATEAINLVAYSWGMNNLK-----------------AGDEIITTVMEH 128 Query: 134 DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 S +P + + A + FV + + ++E + T LVT++ +N G + P Sbjct: 129 HSNLVPWQMVAAKTGAVLKFVQLDE-QESFDLEHFKTLLSEKTKLVTVVHISNTLGCVNP 187 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 EI+ Q+ +G V DA Q+ +DV+ + D+L GHK P Sbjct: 188 AEEIA-------QLAHQAGAK---VLVDACQSAPHYPLDVQLIDCDWLVASGHKMCAPTG 237 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAA 297 IG LY G ++ P FGGG+ F GT LG A Sbjct: 238 IGFLY--GKEEILEAMPPFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAV 295 Query: 298 DLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLR 356 D +++ E + ++ YL + L R++ P +F++ G Sbjct: 296 DYLTDLGMENIHNYEVELTHYLWQGLGQIPQLRLY--GPNPKHGDRAALASFNVAG---- 349 Query: 357 GYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDL 416 + + T++ G + S H P+ A + R S+ T+ E+DL Sbjct: 350 --LHASDVATMVDQDGIAIRSGHH-CTQPLHRLF-----DASGSARASLYFYNTKEEIDL 401 Query: 417 IVQDLKQAVNQL 428 +Q L+ + Sbjct: 402 FLQSLQATIRFF 413 >4EB7-A nrPDB Length = 382 Score = 354 bits (908), Expect = 4e-98, Method: Composition-based stats. Identities = 133/411 (32%), Positives = 208/411 (50%), Gaps = 41/411 (9%) Query: 20 VYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQ 79 Y DY + P++ +++A+ M E++GNPSS + G KA++ + AR +AK++ G Sbjct: 2 AYFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGG 61 Query: 80 DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLP 139 ++FTSG TE+NNL I + H + VEH S+ P Sbjct: 62 TVVFTSGATEANNLAIIGYAMRNARK-----------------GKHILVSAVEHMSVINP 104 Query: 140 LEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISR 199 + L + Q EV ++PV K G+V+V I +R T LV++ ANNE G I P+ EIS Sbjct: 105 AKFL-QKQGFEVEYIPVGKY-GEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISE 162 Query: 200 RIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR-IGALYV 258 + + +H DA ++G+ VDVE +G D LTI + YGP+ +GAL++ Sbjct: 163 VLAG-----------KAALHIDATASVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWI 211 Query: 259 RGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVS-ENCETYEAHMRDIRDY 317 R KL P++ GGGQE R G+EN P I G GKAA++ + E E E R Sbjct: 212 RKEAKL---QPVILGGGQENGLRSGSENVPSIVGFGKAAEITAMEWREEAERLRRLRDRI 268 Query: 318 LEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHS 377 ++ L+ E +LN +RLPN N + ++ + AS G++C S Sbjct: 269 IDNVLKIE---ESYLNGHPE--KRLPNNVNVRFSYIEGESIVLSLDMAGIQASTGSAC-S 322 Query: 378 DHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 +PS VL++CG+ + A + L++GR T +VD +++ L + +L Sbjct: 323 SKTLQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERL 373 >4W91-A nrPDB Length = 422 Score = 353 bits (906), Expect = 8e-98, Method: Composition-based stats. Identities = 110/437 (25%), Positives = 165/437 (37%), Gaps = 66/437 (15%) Query: 11 SVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARAS 69 S + VY+D A+ VI AVT A + N + A D +R + Sbjct: 32 SRQVHGKTLVYLDNGASAQKPQSVIDAVTHAYANEYANVHRGLHFLSNAATDAYEKSRET 91 Query: 70 LAKMIGGKP-QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFIT 128 + + + +I+FT TE+ N V + P G + Sbjct: 92 VRRFLNAGSVDEIVFTKNATEAINTVAYGYGM-----------------PFIGEGDEILL 134 Query: 129 CTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNET 188 +EH S +P + E Q A++ F PV NG +E+ + T LV I +N Sbjct: 135 SIMEHHSNIVPWHFIRERQGAKLVFTPVD-DNGVFHIEEFEKRLSERTKLVAITHMSNTL 193 Query: 189 GVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKF 248 G ++PI +I ++ A G+P V D +Q VDV+DLG D+ GHK Sbjct: 194 GTVVPIKKIV-------ELAHARGIP---VLVDGSQGAVHLPVDVQDLGCDWYVFTGHKV 243 Query: 249 YGPR-IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAG 292 YGP IG LY R ++ GGG+ F GT G Sbjct: 244 YGPSGIGVLYGRA--QMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIG 301 Query: 293 LGKAADLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQ 351 LG A + + + AH D+RDY ERL RI N+ G +F+++ Sbjct: 302 LGAALEYMEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKG-----AIISFALE 356 Query: 352 GSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTR 411 G ++ + G C P+L G+ + R S TR Sbjct: 357 GIHAHDVSMVIDRAGVAVRAGTHC-------AQPLLKRFGV-----TSTCRASFALYNTR 404 Query: 412 AEVDLIVQDLKQAVNQL 428 AEVD + + L++A Sbjct: 405 AEVDALAEALEKARKFF 421 >4ISY-A nrPDB Length = 404 Score = 341 bits (874), Expect = 4e-94, Method: Composition-based stats. Identities = 131/418 (31%), Positives = 215/418 (51%), Gaps = 35/418 (8%) Query: 9 RGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARA 68 RGS + Y+D+ ATTP+ P I+A+ A++ GN SS + +GR A+ I AR Sbjct: 2 RGSHHHHHHGSAYLDHAATTPMHPAAIEAMA-AVQRTIGNASSLHTSGRSARRRIEEARE 60 Query: 69 SLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFIT 128 +A +G +P ++IFT+GGTES+NL + + E R +T Sbjct: 61 LIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDA--------------EPHRRRIVT 106 Query: 129 CTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVR--PTTCLVTIMLANN 186 VEH ++ + LVE + A VT++P + +G V + A++ LV++M ANN Sbjct: 107 TEVEHHAVLDSVNWLVEHEGAHVTWLP-TAADGSVSATALREALQSHDDVALVSVMWANN 165 Query: 187 ETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGH 246 E G I+PI+E+S + G+P +H+DA QA+G+ +D G+ +++ GH Sbjct: 166 EVGTILPIAEMS-------VVAMEFGVP---MHSDAIQAVGQLPLDFGASGLSAMSVAGH 215 Query: 247 KFYGPR-IGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCE 305 KF GP +GAL +R + P++ GGGQER+ R GT + G+ AA + + E Sbjct: 216 KFGGPPGVGALLLR---RDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLE 272 Query: 306 TYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQ 365 A +R +RD L E + AE + P RL +F+ +G + ++L Sbjct: 273 ENSARLRLLRDRLVEGVLAEIDDVCLNGADDP--MRLAGNAHFTFRGCEGDALLMLLDAN 330 Query: 366 TLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQ 423 + S G++C + +PS VL++ G+ AR ++RLS+G ++ A+VD ++ L Sbjct: 331 GIECSTGSACTAG-VAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVLPG 387 >5XT5-A nrPDB Length = 419 Score = 337 bits (863), Expect = 6e-93, Method: Composition-based stats. Identities = 94/429 (21%), Positives = 160/429 (37%), Gaps = 65/429 (15%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARASLAKMI 74 + VY+D AT+ VI+ + + + N + G +A D AR + K I Sbjct: 22 GHDLVYLDSAATSQKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFI 81 Query: 75 GGKPQ-DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEH 133 K +IIFT G T S N+V S R + + +EH Sbjct: 82 NAKSMAEIIFTKGTTTSLNMVALSYARANLKP-----------------GDEVVITYMEH 124 Query: 134 DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP 193 + +P + V+ A + ++P+ + +G + +ED+ V T +V + +N G + P Sbjct: 125 HANIIPWQQAVKATGATLKYIPLQE-DGTISLEDVRETVTSNTKIVAVSHVSNVLGTVNP 183 Query: 194 ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR- 252 I E+++ +G ++ D AQ+ ++DV+DL DF + HK GP Sbjct: 184 IKEMAKI-------AHDNG---AVIVVDGAQSTPHMKIDVQDLDCDFFALSSHKMCGPTG 233 Query: 253 IGALYVRGVGKLTPLYPMLFGGGQ--------------ERNFRPGTENTPMIAGLGKAAD 298 +G LY + L + P FGG F GT GLG A D Sbjct: 234 VGVLYGK-KALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAID 292 Query: 299 LVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRG 357 + E + H + Y ER G ++ E F++ Sbjct: 293 FLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGP------EERAGLVTFNLDD----- 341 Query: 358 YMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLI 417 + T+L + G + + H P++ + R S T E+D + Sbjct: 342 -VHPHDVATVLDAEGIAVRAGHH-CAQPLMKWLDVTA-----TARASFYLYNTEEEIDKL 394 Query: 418 VQDLKQAVN 426 V+ L++ Sbjct: 395 VEALQKTKE 403 >6C9E-A nrPDB Length = 422 Score = 337 bits (863), Expect = 7e-93, Method: Composition-based stats. Identities = 109/445 (24%), Positives = 173/445 (38%), Gaps = 71/445 (15%) Query: 6 NGARGSVESPPNR-----KVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKA 59 N R + VY D ATT VI A+ + ++ N + +A Sbjct: 22 NKIRKDFPVLHQKINEYDLVYFDNAATTQKPKAVIDAIAQFYEKDNSNVHRGVHALSVRA 81 Query: 60 KDIINTARASLAKMIGGK-PQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISP 118 ++ ARA + + I + P++ IF G TE+ NLV S V +P Sbjct: 82 TEMYEAARAKVKRFINARSPRECIFVRGTTEAINLVAQSLV-----------------AP 124 Query: 119 EEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCL 178 + +EH S +P + + + ++ P+S +NG+V +E+ + T + Sbjct: 125 RILPDEEILITHMEHHSNIVPWQMVCKKMGCKLQVAPIS-LNGEVILEEFERKLNENTKM 183 Query: 179 VTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGV 238 V I A+N G I P+ + IK +++ A V D AQA VDV+DL Sbjct: 184 VAINYASNSLGTINPVKTM---IKMAHEVGAK-------VLLDGAQATAHLIVDVQDLDC 233 Query: 239 DFLTIVGHKFYGPR-IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRP 282 DF GHK YGP IG L+ G +L GGG+ F Sbjct: 234 DFYAFSGHKMYGPTGIGVLW--GKEELLNSMTPYQGGGEMINSVSFEATEYAAIPHKFEA 291 Query: 283 GTENTPMIAGLGKAADLV-SENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVER 341 GT N GL A D + S + + + + +Y + +EA G I Sbjct: 292 GTPNIAGAIGLAAAIDYIWSLDLDAIAEYETQLLNYATKAIEAVKGYNI----------- 340 Query: 342 LPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAV 401 + N S + G + T+L S G + S H P++ DVA + Sbjct: 341 IGTAANKVPIISFVHGKIHAHDIGTILDSEGIAIRSGHH-CTMPLMDFY----DVAATS- 394 Query: 402 RLSVGRSTTRAEVDLIVQDLKQAVN 426 R+S+ T E+D ++ L++ Sbjct: 395 RISMSFYNTFKEIDYCMEALQRVKE 419 >4Q75-A nrPDB Length = 429 Score = 336 bits (861), Expect = 1e-92, Method: Composition-based stats. Identities = 107/446 (23%), Positives = 167/446 (37%), Gaps = 64/446 (14%) Query: 5 RNGARGSV-ESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDI 62 R R E ++ VY+D AT+ V+ A+ + N + KA D Sbjct: 24 RKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSNVHRGIHYLSAKATDE 83 Query: 63 INTARASLAKMIGG-KPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEG 121 AR +A+ I ++I+FT TE+ NLV +S + + P + Sbjct: 84 FELARKKVARFINASDSREIVFTRNATEAINLVAYSWG-------------LSNLKPGD- 129 Query: 122 TRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTI 181 I EH S +P + + + A + FV +++ + ++ + + P T LV + Sbjct: 130 ---EVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNE-DEVPDINKLRELISPKTKLVAV 185 Query: 182 MLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFL 241 +N +PI EI + A +VLV DA Q++ VDV+ L DFL Sbjct: 186 HHVSNVLASSLPIEEIV--------VWAHDVGAKVLV--DACQSVPHMVVDVQKLNADFL 235 Query: 242 TIVGHKFYGPR-IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTE 285 HK GP IG LY G L P GGG+ F GT Sbjct: 236 VASSHKMCGPTGIGFLY--GKSDLLHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTP 293 Query: 286 NTPMIAGLGKAADLVS-ENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPN 344 LG A D +S + +I YL E+L + RI+ V R Sbjct: 294 AIGEAIALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHR-GA 352 Query: 345 TCNFSIQGSQLRGYMVLAQCQTLLASV-GASCHSDHEDRPSPVLLSCGIPVDVARNAVRL 403 C+F+++G + T L G + S H P+ G+ + R Sbjct: 353 LCSFNVEG------LHPTDLATFLDQQHGVAIRSGHH-CAQPLHRYLGVNA-----SARA 400 Query: 404 SVGRSTTRAEVDLIVQDLKQAVNQLE 429 S+ T+ +VD + L V+ Sbjct: 401 SLYFYNTKDDVDAFIVALADTVSFFN 426 >6MRE-A nrPDB Length = 420 Score = 324 bits (831), Expect = 3e-89, Method: Composition-based stats. Identities = 99/438 (22%), Positives = 160/438 (36%), Gaps = 68/438 (15%) Query: 11 SVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSS-YVAGRKAKDIINTARAS 69 S E Y+D A+ +VI A E + + + +A + + R Sbjct: 30 SREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQATEKMENVRKR 89 Query: 70 LAKMIGGKP-QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFIT 128 + I + ++++F +G TE NLV +S + I Sbjct: 90 ASLFINARSAEELVFVAGTTEGINLVANSWGNSNVR-----------------AGDNIII 132 Query: 129 CTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNET 188 +EH + +P + L AE+ +P++ +G +++E + T L+ I +N Sbjct: 133 SQMEHHANIVPWQMLCARVGAELRVIPLNP-DGTLQLETLPTLFDEKTRLLAITHVSNVL 191 Query: 189 GVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKF 248 G P++E+ I +Q A V D AQA+ VDV+ L DF GHK Sbjct: 192 GTENPLAEM---ITLAHQHGAK-------VLVDGAQAVMHHPVDVQALDCDFYVFSGHKL 241 Query: 249 YGPR-IGALYVRGVGKLTPLYPMLFGGGQ----------------ERNFRPGTENTPMIA 291 YGP IG LYV+ L P GGG F GT NT I Sbjct: 242 YGPTGIGILYVKEA--LLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGII 299 Query: 292 GLGKAADLVS-ENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSI 350 GLG A + VS + +++ Y +LE+ ++ GV Sbjct: 300 GLGAALEYVSALGLNNIAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVI---------- 349 Query: 351 QGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTT 410 + G + L + G + + H P++ +P R S+ T Sbjct: 350 --AFNLGKHHAYDVGSFLDNYGIAVRTGHH-CAMPLMAYYNVPA-----MCRASLAMYNT 401 Query: 411 RAEVDLIVQDLKQAVNQL 428 EVD +V L++ L Sbjct: 402 HEEVDRLVTGLQRIHRLL 419 >4LW2-A nrPDB Length = 404 Score = 317 bits (812), Expect = 6e-87, Method: Composition-based stats. Identities = 93/443 (20%), Positives = 162/443 (36%), Gaps = 76/443 (17%) Query: 9 RGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPS-SSYVAGRKAKDIINTAR 67 R + + VY+D AT V++A + + GN S + ++ AR Sbjct: 13 RAQFPALQDAGVYLDSAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAR 72 Query: 68 ASLAKMIGG-KPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHF 126 +A+++ + I++T G TES N+V R P Sbjct: 73 EKVAQLLNAPDDKTIVWTRGTTESINMVAQCYAR-----------------PRLQPGDEI 115 Query: 127 ITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANN 186 I EH + +P + + A+V +P++ +V+ + + P + ++ + +N Sbjct: 116 IVSVAEHHANLVPWLMVAQQTGAKVVKLPLNAQR-LPDVDLLPELITPRSRILALGQMSN 174 Query: 187 ETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGH 246 TG +++R I + +V D AQ DV+ L +DF GH Sbjct: 175 VTG---GCPDLARAITFAHSAGM-------VVMVDGAQGAVHFPADVQQLDIDFYAFSGH 224 Query: 247 KFYGPR-IGALYVRGVGKLTPLYPMLFGGGQ---------------ERNFRPGTENTPMI 290 K YGP IG LY G +L GGG+ GT N + Sbjct: 225 KLYGPTGIGVLY--GKSELLEAMSPWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGV 282 Query: 291 AGLGKAADLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFS 349 GL A + +++ + E+ R + E+ L + P +F Sbjct: 283 IGLSAALEWLADYDINQAESWSRSLATLAEDALA-----------------KRPGFRSFR 325 Query: 350 IQGSQLRGYMVL----AQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSV 405 Q S L + + TLLA G + + P+L G+ +R S Sbjct: 326 CQDSSLLAFDFAGVHHSDMVTLLAEYGIALRAGQH-CAQPLLAELGV-----TGTLRASF 379 Query: 406 GRSTTRAEVDLIVQDLKQAVNQL 428 T+++VD +V + +A+ L Sbjct: 380 APYNTKSDVDALVNAVDRALELL 402 >3CAI-A nrPDB Length = 406 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 75/426 (17%), Positives = 153/426 (35%), Gaps = 41/426 (9%) Query: 2 DVARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKD 61 DVAR RG S + V+ D A + V V+ A + + + ++ + R++ Sbjct: 12 DVAR--VRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRRSGASTVGAHPSARRSAA 69 Query: 62 IINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEG 121 +++ AR ++A ++ P ++ + ++ L + S G Sbjct: 70 VLDAAREAVADLVNADPGGVVLGA------------------DRAVLLSLLAEASSSRAG 111 Query: 122 TRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTI 181 I ++ ++ P A+V + V G++ + + +T LV + Sbjct: 112 LGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRLVAV 171 Query: 182 MLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFL 241 N+ +G + ++++ K ++ + A LV D + A R +D+ + D + Sbjct: 172 ---NSASGTLGGVTDLRAMTKLVHDVGA-------LVVVDHSAAAPYRLLDIRETDADVV 221 Query: 242 TIVGHKFYGPRIGALYVRGVGKLTPL--YPMLFGGGQERNFRPGTENTPMIAGLGKAADL 299 T+ H + GP IGA+ R + G ++AG+ + + Sbjct: 222 TVNAHAWGGPPIGAMVFRDPSVMNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEY 281 Query: 300 VSENCETYEAHMRDIRDYLEER----LEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQL 355 ++ E+ R+ + L F + P V + S Sbjct: 282 LAALDESARGSRRERLAVSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFA 341 Query: 356 RGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVD 415 + + LA G ++ R VL G+ AV + + +T AEVD Sbjct: 342 VHKVPADRVVQRLADNGILAIANTGSR---VLDVLGVND--VGGAVTVGLAHYSTMAEVD 396 Query: 416 LIVQDL 421 +V+ L Sbjct: 397 QLVRAL 402 >5HH9-A nrPDB Length = 390 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 83/419 (19%), Positives = 144/419 (34%), Gaps = 63/419 (15%) Query: 18 RKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIIN-TARASLAKMIGG 76 + ++ T V +A+ NP + R+ ARA + Sbjct: 15 QYLHFANFLLTSHPRPVREAIERLRVRFDRNPGEAVDWHREEIWKYEDEARAWAGRYFAV 74 Query: 77 KPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSI 136 +P + T T+ + G +T + EH S Sbjct: 75 QPGQVALTGSTTD-------GLAAIYGGLLVQPG-------------KEILTSSHEHYST 114 Query: 137 RLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDIL----AAVRPTTCLVTIMLANNETGVIM 192 LE+ + +V P+ K +V ++IL A +RP T ++ + + +GV + Sbjct: 115 YTTLEYRHKRMGTQVREFPLFKDPHRVSADEILSSIAAQIRPQTRVLGMTWVQSGSGVKL 174 Query: 193 PISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKF-YGP 251 PI EI + ++ LNQ R R++ D G V D D+ HK+ +GP Sbjct: 175 PIREIGKLVRELNQKRDEQD--RIIYVVDGVHGFGVEDVSFADFDCDYFIAGTHKWLFGP 232 Query: 252 R-IGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTP-------MIAGLGKAADL-VSE 302 R G + R L P + + NF GT TP LG A +L + Sbjct: 233 RGTGVIIARSEQLQEHLVPSIPTFSRADNF--GTLMTPGGYHAFEHRLALGTAFELHLQL 290 Query: 303 NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLA 362 +A + + YL++RL R+ + F ++G Sbjct: 291 GKAEVQARIHQLNAYLKQRLGEHPKVRLVTPTSPELS---SGFTFFRVEGRD-------- 339 Query: 363 QCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDL 421 C + + + ++S + DV VRL+ AE+D +++ L Sbjct: 340 ------------CEAVAKHLMAHRVISDAVDRDVGP-VVRLAPSLLNDEAEIDRVLEIL 385 >1QZ9-A nrPDB Length = 416 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 70/443 (15%), Positives = 129/443 (29%), Gaps = 94/443 (21%) Query: 14 SPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGN--PSSSYVAGRKAKDIINTARASLA 71 + P +Y+D N+ + + E WGN S AG + D+ LA Sbjct: 24 ALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGLIRSWNSAGWR--DLSERLGNRLA 81 Query: 72 KMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTV 131 +IG + +++ T T S NL ++ I Sbjct: 82 TLIGARDGEVVVTD--TTSINL-------------FKVLSAALRVQATRSPERRVIVTET 126 Query: 132 EHDSIRLPLEHLVE------DQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLAN 185 S ++ E Q + V E++ A+ T +V + N Sbjct: 127 ---SNFPTDLYIAEGLADMLQQGYTLRLVD--------SPEELPQAIDQDTAVVMLTHVN 175 Query: 186 NETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVG 245 +TG + ++ ++ A L D A + G VD+ G D+ Sbjct: 176 YKTGYMH---DMQALTALSHECGA-------LAIWDLAHSAGAVPVDLHQAGADYAIGCT 225 Query: 246 HKF--YGPRIGALYVRGVGKLTPLYPM----LFGGGQERNFRP-------------GTEN 286 +K+ GP A +V +L L P FG ++ P GT+ Sbjct: 226 YKYLNGGPGSQA-FVWVSPQLCDLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQP 284 Query: 287 TPMIAGLGKAAD-LVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNT 345 +A + D + + + D E +E + + Sbjct: 285 ITSLAMVECGLDVFAQTDMASLRRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGS- 343 Query: 346 CNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSV 405 + S + + + + ++ P +R Sbjct: 344 -HVSFEHPEGYAVIQALIDRGVI---------GDYREPR---------------IMRFGF 378 Query: 406 GR-STTRAEVDLIVQDLKQAVNQ 427 TT EV VQ L + +++ Sbjct: 379 TPLYTTFTEVWDAVQILGEILDR 401 >5V1X-E nrPDB Length = 501 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 49/301 (16%), Positives = 94/301 (31%), Gaps = 51/301 (16%) Query: 63 INTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGT 122 ++ +RA++A ++ + ++F + T N V+ + V + + G Sbjct: 89 LDESRAAVANLLKVPVETVVFVANATMGVNTVLRNIVWSADGKDEILYFDT-----IFGA 143 Query: 123 RPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRP---TTCLV 179 I +E + + P + D + R L Sbjct: 144 CGKTIDYVIEDKRGIVSSRCIP-------LIYPAEDDDVVAAFRDAIKKSREEGKRPRLA 196 Query: 180 TIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVD 239 I + ++ GV P +I + K ++ D AQ +G + + + D Sbjct: 197 VIDVVSSMPGVRFPFEDIVKICKE----------EEIISCVDGAQGIGMVDLKITETDPD 246 Query: 240 FLTIVGHKF-YGPRIGALY---VRGVGKLTPLYPMLFGG--------------GQERNFR 281 FL HK+ + PR A++ VR + P G G + F Sbjct: 247 FLISNCHKWLFTPRGCAVFYVPVRNQHLIRSTLPTSHGFVPQVGNRFNPLVPAGNKSAFV 306 Query: 282 P-----GTENTPMIAGLGKAADLVSE---NCETYEAHMRDIRDYLEERLEAEFGKRIHLN 333 GT + + A E E +M + +++ G R+ N Sbjct: 307 SNFEFVGTVDNSPFFCVKDAIKWREEVLGGEERIMEYMTKLAREGGQKVAEILGTRVLEN 366 Query: 334 S 334 S Sbjct: 367 S 367 >2DR1-A nrPDB Length = 386 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 48/303 (15%), Positives = 97/303 (32%), Gaps = 51/303 (16%) Query: 143 LVEDQVAEVTFVPVSKVNGQVEVEDILAAVR--PTTCLVTIMLANNETGVIMPISEISRR 200 +VE + + V+ ED+ A+R P VTI TGV+ P+ E+++ Sbjct: 113 VVESNGRKAVVLEYEPGKA-VKPEDLDDALRKNPDVEAVTITYNETSTGVLNPLPELAKV 171 Query: 201 IKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVRG 260 K ++ LV DA A+G + + G+D + K +G G Sbjct: 172 AKEHDK----------LVFVDAVSAMGGADIKFDKWGLDVVFSSSQKAFGVPPGLAIGAF 221 Query: 261 VGKLTPLYPMLFGGG------------QERNFRPGTENTPMIAGLGKAADLVSE--NCET 306 + + + G +E+ P T P + G+ A ++ + E Sbjct: 222 SERFLEIAEKMPERGWYFDIPLYVKYLKEKESTPSTPPMPQVFGINVALRIIEKMGGKEK 281 Query: 307 YEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQT 366 + + E + + PG E T + G + + + Sbjct: 282 WLEMYEKRAKMVREGVREIGLDIL----AEPGHESPTITAVLTPPGIKGDEVYEAMRKRG 337 Query: 367 LLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVN 426 + G V R+ ++ ++ +L++ +N Sbjct: 338 FELAKGYG--------------------SVKEKTFRIGHMGYMKFEDIQEMLDNLREVIN 377 Query: 427 QLE 429 +L+ Sbjct: 378 ELK 380 >4Q6R-A nrPDB Length = 511 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 52/313 (16%), Positives = 100/313 (31%), Gaps = 32/313 (10%) Query: 36 QAVTEAMKEAWGN---PSSSYVAGRKAKDIINTARASLA-KMIGGKPQDI-IFTSGGTES 90 + +TE + +A+G+ + + I +A + G P TSGGTES Sbjct: 97 EKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTES 156 Query: 91 NNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAE 150 + + E+ P + H + + Sbjct: 157 ILMACKAYRDLAFEKGIKT--------------PEIVAPQSAHAA----FNKAASYFGMK 198 Query: 151 VTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRR-IKALNQIRA 209 + VP++K+ +V+V + A+ T ++ GVI P+ E+++ +K + Sbjct: 199 IVRVPLTKMM-EVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHV 257 Query: 210 ASGLPRVLVHTDAAQALG-KRRVDVEDLGVDFLTIVGHKF-YGPRIGALYVRGVGKLTPL 267 + L L+ + D GV ++ HK+ Y P+ +L + K Sbjct: 258 DACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNY 317 Query: 268 Y----PMLFGGGQERNFRPGTENTPMIAGLGKA-ADLVSENCETYEAHMRDIRDYLEERL 322 GG G+ + A A + +L+ L Sbjct: 318 QFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSEL 377 Query: 323 EAEFGKRIHLNSR 335 E G + N + Sbjct: 378 ENIKGIFVFGNPQ 390 >2BKW-A nrPDB Length = 385 Score = 61.1 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 80/272 (29%), Gaps = 46/272 (16%) Query: 145 EDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTC-LVTIMLANNETGVIMPISEISRRIKA 203 A+V V K+ V +E I + + VT+ + T V+ + IS+ IK Sbjct: 106 RSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIK- 164 Query: 204 LNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGAL------- 256 P DA ++G + ++ GVDF K G G Sbjct: 165 -------QTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSR 217 Query: 257 ----------------YVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAA-DL 299 Y + + TP+ G + T +I L A ++ Sbjct: 218 FMDYALNDSKNGHVHGYFSSLRRWTPIMENYEAG---KGAYFATPPVQLINSLDVALKEI 274 Query: 300 VSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYM 359 + E R++ D+ ++ L + V R P+ N S G Sbjct: 275 LEEGLHKRWDLHREMSDWFKDSLV--------NGLQLTSVSRYPS--NMSAHGLTAVYVA 324 Query: 360 VLAQCQTLLASVGASCHSDHEDRPSPVLLSCG 391 L S G P + G Sbjct: 325 DPPDVIAFLKSHGVVIAGGIHKDIGPKYIRIG 356 >5DX5-A nrPDB Length = 400 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 71/385 (18%), Positives = 128/385 (33%), Gaps = 32/385 (8%) Query: 57 RKAKDIINTARASLAKMIGGKPQDIIFTSG---GTESNN-LVIHSTVRCFHEQQTLQGRT 112 + + I ++A + G + I G TE N L + + G Sbjct: 33 QTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAI 92 Query: 113 VDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAV 172 + + H + + L H + EVTFV VS ++++ A+ Sbjct: 93 AASLWSALKSGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDVS------NLDEVKNAL 146 Query: 173 RPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVD 232 +P T +V + N T + I +IS + N+ V D + Sbjct: 147 KPNTKVVYLETPANPTLKVTDIRKISNMVHESNK--------ECFVFVDNTFCTPYIQRP 198 Query: 233 VEDLGVDFLTIVGHKF---YGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPM 289 +E LG D + K+ +G I V + + LFG G + + Sbjct: 199 LE-LGADVVVHSATKYLNGHGDVIAGFAVGKEEFINQVK--LFGIKDMTGSVTGPFESFL 255 Query: 290 IA-GLGKAADLVSENCETYEAHMRDIRDY-LEERLEAEFGKRIHLNSRFPGVERLPNT-C 346 I G+ + ++C+ + + + E++ + +LP Sbjct: 256 IIRGMKTLQLRMEKHCKNAMEVAKFLESHPAVEKVYYPGLESFKYYQLAREQMKLPGAMI 315 Query: 347 NFSIQGSQLRGYMVLAQCQ--TLLASVGASCHSDHEDRP---SPVLLSCGIPVDVARNAV 401 +F ++G G +V+ + TL S+G S SP ++ V Sbjct: 316 SFELKGGVEEGKIVMNNVKLATLAVSLGDSETLIQHPASMTHSPYTAEERKAAGISDGLV 375 Query: 402 RLSVGRSTTRAEVDLIVQDLKQAVN 426 RLSVG +D + Q L V Sbjct: 376 RLSVGLEDAEDIIDDLKQALDLIVK 400 >3ZRR-A nrPDB Length = 384 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 35/209 (16%), Positives = 63/209 (30%), Gaps = 28/209 (13%) Query: 140 LEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISR 199 E + + V + S + E + LV + TGV P+ ++ Sbjct: 92 WEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVIN 151 Query: 200 RIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVR 259 +I+ + L+ D ++G V E+ VD K G G + Sbjct: 152 KIRKYVE----------LIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLL 201 Query: 260 GVGK-----------------LTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVS- 301 K L P++ G + + T +I L +A L+ Sbjct: 202 LSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLIEK 261 Query: 302 ENCETYEAHMRDIRDYLEERLEAEFGKRI 330 E E + + LEA + + Sbjct: 262 EGIENRIKRHTMVASAIRAGLEALGLEIV 290 >1VJO-A nrPDB Length = 393 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 95/302 (31%), Gaps = 53/302 (17%) Query: 143 LVEDQVAEVTFVPVSKVNGQV-EVEDILAAV-RPTTCLVTIMLANNETGVIMPISEISRR 200 + A+V +SK G+V +E++ A+ ++ ++ A TG P+ + Sbjct: 127 MAGRYGADVR--TISKPWGEVFSLEELRTALETHRPAILALVHAETSTGARQPLEGVGEL 184 Query: 201 IKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGAL---- 256 + L+ D +LG + ++ GVD K G GA Sbjct: 185 CREFG----------TLLLVDTVTSLGGVPIFLDAWGVDLAYSCSQKGLGCSPGASPFTM 234 Query: 257 -------YVRGVGKLTPLYPMLFGGGQERNFRP---GTENTPMIAGLGKAAD-LVSENCE 305 R K+ Y + G+ T + L +A + E Sbjct: 235 SSRAIEKLQRRRTKVANWYLDMNLLGKYWGSERVYHHTAPINLYYALREALRLIAQEGLA 294 Query: 306 TYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQ 365 + +YL ERLE I L+ RLP I + G V + Sbjct: 295 NCWQRHQKNVEYLWERLED-----IGLSLHVEKEYRLPTLTTVCIPDG-VDGKAVARRLL 348 Query: 366 TLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAE-VDLIVQDLKQA 424 + G ++A R+ + +R E VD ++ L+Q Sbjct: 349 N-----------------EHNIEVGGGLGELAGKVWRVGLMGFNSRKESVDQLIPALEQV 391 Query: 425 VN 426 + Sbjct: 392 LR 393 >1XI9-A nrPDB Length = 406 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 56/317 (17%), Positives = 104/317 (32%), Gaps = 47/317 (14%) Query: 19 KVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKP 78 V D+ + +A +A+KE S K I+ R + P Sbjct: 48 PVKFDF----QPPEHMKEAYCKAIKEGHNYYGDSEGLPELRKAIVE--REKRKNGVDITP 101 Query: 79 QDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRL 138 D+ T+ TE+ L+ + + D+I + P Sbjct: 102 DDVRVTAAVTEALQLIFGALLD-----------PGDEILVPGPSYP-------------- 136 Query: 139 PLEHLVEDQVAE-VTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEI 197 P LV+ + V + + + + Q +++DI + T + ++ NN TG + + Sbjct: 137 PYTGLVKFYGGKPVEYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALYDKKTL 196 Query: 198 SRRIKALNQIRAASGLPRV--LVHTDAAQ-ALGKRRVDVEDLGVDFLTIVGHKFY---GP 251 + + + L+ + + G DV + ++ L+ K Y G Sbjct: 197 EEILNIAGEYEIPVISDEIYDLMTYEGEHISPGSLTKDVPVIVMNGLS----KVYFATGW 252 Query: 252 RIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTEN-TPMIAGLGKAADLVSENCETYEAH 310 R+G +Y P T IAGL D + Y Sbjct: 253 RLGYMYFVDPENKLSEVREAIDRLARIRLCPNTPAQFAAIAGLTGPMDYLK----EYMKK 308 Query: 311 MRDIRDYLEERLEAEFG 327 +++ RDY+ +RL G Sbjct: 309 LKERRDYIYKRLNEIPG 325 >2E7J-A nrPDB Length = 371 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 95/304 (31%), Gaps = 46/304 (15%) Query: 133 HDSIRLPLEHLVEDQVAEVTFVP-VSKVNGQVEVEDILAAVRPTTC-----LVTIMLANN 186 H S + E + VP + + E+ + T L I + Sbjct: 103 HYSSYV----AAERAGLNIALVPKTDYPDYAITPENFAQTIEETKKRGEVVLALITYPDG 158 Query: 187 ETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGH 246 G + + +I++ + V + + A A+G+ V ++++G DF+ GH Sbjct: 159 NYGNLPDVKKIAKVCSEYD----------VPLLVNGAYAIGRMPVSLKEIGADFIVGSGH 208 Query: 247 K---FYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSEN 303 K GP IG + ++ L +E T I L + V E Sbjct: 209 KSMAASGP-IGVMGMKEEWAEIVLRRSEKYKNKEVELLGCTARGATIITLMASFPHVRER 267 Query: 304 CETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQ 363 + ++ + R + E +E K++ N + + I G L + Sbjct: 268 IKRWDEEVEKARRFAAE-MEKLGIKQLGDNPHNHDLMFFHAEVLYEISKKAKGGRFFLYR 326 Query: 364 CQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQ 423 S P G+ + LS EVD ++ K+ Sbjct: 327 ----------ELKSRKIHGIKP-----GLTRYFKLSTYGLS------DEEVDYVLNAFKE 365 Query: 424 AVNQ 427 + + Sbjct: 366 IIEK 369 >5K1R-A nrPDB Length = 480 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 44/227 (19%), Positives = 65/227 (28%), Gaps = 13/227 (5%) Query: 95 IHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFV 154 S + RP I H + +VT Sbjct: 121 ALSLGGTESILNATLAYREKARAERGIERPRMIWPASAHPA----FRKAAHLFGFDVTVA 176 Query: 155 PVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLP 214 P+ V QV+ + + AV T ++ N G I PI +S + G Sbjct: 177 PIDPVTMQVDADFVRDAVDANTVMLVGSACNYPYGTIDPIGALSAIAVEKDVWLHVDGCL 236 Query: 215 RVLVHTDA-AQALGKRR-VDVEDLGVDFLTIVGHKF-YGPRIGALYVRGVGKLTP----L 267 + A D GV ++ HKF YGP+ G++ L Sbjct: 237 GGWMLPWGEALGYPDIPAFDFRLPGVTSISADTHKFGYGPKGGSVLAWRDASFRRHQYFL 296 Query: 268 YPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDI 314 GG G+ + +IA A S E Y A + I Sbjct: 297 MTDWVGGVYGSPGLTGSRSGGLIAATWAALR--SLGREGYLARAKAI 341 >3OP7-A nrPDB Length = 375 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 52/267 (19%), Positives = 101/267 (37%), Gaps = 54/267 (20%) Query: 67 RASLAKM-IGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPH 125 + S++++ G KP+ I+ T+G T +N LV++S + G V + P Sbjct: 69 KKSVSQLYTGVKPEQILQTNGATGANLLVLYSLIE--------PGDHVISLYPTYQQLYD 120 Query: 126 FITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNG-QVEVEDILAAVRPTTCLVTIMLA 184 + AEV + + NG ++E + +RPTT ++ I A Sbjct: 121 I-----------------PKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICINNA 163 Query: 185 NNETGVIMP---ISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFL 241 NN TG +M + E+ + + + R D + ++V D G+ Sbjct: 164 NNPTGAVMDRTYLEELVEIASEVGAYILSDEVYRSFSELD----VPSI-IEVYDKGIAVN 218 Query: 242 TIVGHKFYG-PRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMI-------AGL 293 ++ K Y P I +V ++T + R++R T + L Sbjct: 219 SLS--KTYSLPGIRIGWVAANHQVTDIL---------RDYRDYTMICAGVFDDLVAQLAL 267 Query: 294 GKAADLVSENCETYEAHMRDIRDYLEE 320 +++ N E ++ + ++EE Sbjct: 268 AHYQEILERNRHILEENLAILDQWIEE 294 >5GP4-C nrPDB Length = 468 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 70/439 (15%), Positives = 138/439 (31%), Gaps = 58/439 (13%) Query: 4 ARNGARGSVESPPNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDII 63 A R + N ++ + T +EPE ++ + + +++ S Y + +I Sbjct: 44 ADRLVRDQLLDEGNSRLNLATFCQTYMEPEAVELMKDTLEK-NAIDKSEYP---RTAEIE 99 Query: 64 NTARASLAKMIGGKPQDIIF---TSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEE 120 N +A + + T G +E+ L + + ++ G + Sbjct: 100 NRCVNIIANLWHAPEAESFTGTSTIGSSEACMLAGLAMKFAWRKRAKANGLDLTA----- 154 Query: 121 GTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTC-LV 179 +P+ + ++ E ++ VP+ + + V+ +L V T +V Sbjct: 155 -HQPNIVISA----GYQVCWEKFCVYWDIDMHVVPMDDDHMSLNVDHVLDYVDDYTIGIV 209 Query: 180 TIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVD 239 IM TG ++ + ++ N+ + V +H DAA +L D Sbjct: 210 GIMGIT-YTGQYDDLARLDAVVERYNR----TTKFPVYIHVDAASGGFYTPFIEPELKWD 264 Query: 240 F-------LTIVGHKFYG---PRIGALYVRG---VGKLTPLYPMLFGGGQE---RNF-RP 282 F + GHK YG P +G + R + K GG NF Sbjct: 265 FRLNNVISINASGHK-YGLVYPGVGWVIWRDQQYLPKELVFKVSYLGGELPTMAINFSHS 323 Query: 283 GTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERL 342 ++ + + D+ YL + L G + + L Sbjct: 324 ASQLIGQYYNF---IRFGFDGYREIQEKTHDVARYLAKSLTKLGGFSLINDG-----HEL 375 Query: 343 PNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVR 402 P C S + + L+ + P+ + + R VR Sbjct: 376 PLICYELTADSDREWTLYDLSDRLLM--------KGWQVPTYPLPKNMT-DRVIQRIVVR 426 Query: 403 LSVGRSTTRAEVDLIVQDL 421 G S +D + Q + Sbjct: 427 ADFGMSMAHDFIDDLTQAI 445 >1V2E-A nrPDB Length = 381 Score = 53.0 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 61/338 (18%), Positives = 116/338 (34%), Gaps = 65/338 (19%) Query: 27 TTPLEPEVIQAVTEAM--KEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFT 84 + P P +++AV A+ ++ + P+ + R +LA+ +P+ ++ T Sbjct: 36 SNPPPPFLLEAVRRALGRQDQYAPPAG-----------LPALREALAEEFAVEPESVVVT 84 Query: 85 SGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLV 144 SG TE+ +++ S V E L+ + LP L Sbjct: 85 SGATEALYVLLQSLVGPGDEVVVLEPFFD----------------------VYLPDAFLA 122 Query: 145 EDQVAEVTFVPVSKVNG--QVEVEDILAAVRPTTCLVTIMLANNETGVIMP---ISEISR 199 A+ V + ++++ + A+ P T + + N TG++ + I+R Sbjct: 123 ---GAKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIAR 179 Query: 200 RIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVD--FLTIVGHK---FYGPRIG 254 +A + + + L + G+R + + + F K G R+G Sbjct: 180 LARAHDLFLISDEVYDELYY-------GERPRRLREFAPERTFTVGSAGKRLEATGYRVG 232 Query: 255 ALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHM--R 312 + P L G Q +F TP+ AG+ +A L R Sbjct: 233 WIVGPK-----EFMPRLAGMRQWTSFSA---PTPLQAGVAEALKLARREGFYEALREGYR 284 Query: 313 DIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSI 350 RD L L A + + + LP F + Sbjct: 285 RRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRL 322 >4W8I-A nrPDB Length = 551 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 57/366 (15%), Positives = 110/366 (30%), Gaps = 52/366 (14%) Query: 23 DYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDI-INTARASLAKMIGGKPQDI 81 D A + P+ + + + + A + + + + R G K Sbjct: 101 DSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSKEGYG 160 Query: 82 IFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLE 141 + T GGT S + + V + P + H + + Sbjct: 161 LLTHGGTTSIIEAMAAYVIRARAKGI--------------DYPEIVVPETAHAA----FK 202 Query: 142 HLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRI 201 E A + VPV K G V + + + T ++ + G+ PISE+ + Sbjct: 203 KAAELTGAILITVPVDKKTGAVNPNVMSSYITRNTAVMVGSAPSFMNGIHDPISELGQLA 262 Query: 202 KALNQIRAASGLPRVLVHTDAAQA--------LGKRRVDVEDLGVDFLTIVGHKFYGPRI 253 K N V H DA +D GV ++ HK+ Sbjct: 263 KKKN----------VPFHVDACLGGFLTAFLDTSSEPMDFRVPGVTSISADLHKYGCCPK 312 Query: 254 GA---LYVRGVGKLTPLYPMLFGGG--QERNFRPGTENTPMIAGLGKAADLVSENC-ETY 307 G L+ L+ + + GG G+ + +A + +N + Sbjct: 313 GTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGKNKYQEI 372 Query: 308 EAHMRDIRDYLEERLEAEF---------GKRIHLNSRFPGVERLPNTCNFSIQGSQLRGY 358 + +R+ +++ L A ++ N ++ + NTCN +L Sbjct: 373 AKSIIRLRNAIQKELTALVEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADELEKR 432 Query: 359 MVLAQC 364 Sbjct: 433 GWKLNL 438 >2YRI-A nrPDB Length = 353 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 63/225 (28%), Gaps = 27/225 (12%) Query: 169 LAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGK 228 A R +V ++ TGV+ P I K L DA LG Sbjct: 118 RALKRRRYRMVALVHGETSTGVLNPAEAIGALAKE----------AGALFFLDAVTTLGM 167 Query: 229 RRVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGG---------GQERN 279 + +GVD+ K G + + + G ER Sbjct: 168 LPFSMRAMGVDYAFTGSQKCLSAPPGLAPIAASLEARKAFTGKRGWYLDLARVAEHWERG 227 Query: 280 FRPGTENTPMIAGLGKAADL-VSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPG 338 T + L +A DL + E E R++ ++ E L+A +P Sbjct: 228 GYHHTTPVLLHYALLEALDLVLEEGVAARERRAREVYAWVLEELKA------RGFRPYPK 281 Query: 339 VERLPNTCNFS-IQGSQLRGYMVLAQCQTLLASVGASCHSDHEDR 382 LP +G + + + + G R Sbjct: 282 ASPLPTVLVVRPPEGVDADRLVRALYAEGVAVAGGIGPTRGQVLR 326 >1M32-A nrPDB Length = 366 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 52/166 (31%), Gaps = 24/166 (14%) Query: 161 GQVEVEDILAAV--RPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLV 218 + +V+ I A + PT + ++ + TG++ PI E+ + Sbjct: 115 ARPDVQAIDAILNADPTISHIAMVHSETTTGMLNPIDEVGALAHRYGKT----------Y 164 Query: 219 HTDAAQALGKRRVDVEDLGVDFLTIVGHK-FYG-PRIGALYVRG----------VGKLTP 266 DA + G +D+ L +D+L +K G P + R Sbjct: 165 IVDAMSSFGGIPMDIAALHIDYLISSANKCIQGVPGFAFVIAREQKLAACKGHSRSLSLD 224 Query: 267 LYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMR 312 LY T T + +A +++ H R Sbjct: 225 LYAQWRCMEDNHGKWRFTSPTHTVLAFAQALKELAKEGGVAARHQR 270 >5O5C-A nrPDB Length = 519 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 42/201 (20%), Positives = 74/201 (36%), Gaps = 28/201 (13%) Query: 82 IFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLE 141 IFTSGGT+SN + + + + P + + T + H SI+ + Sbjct: 165 IFTSGGTQSNLMAMLLARDSWCAAHHPGHLIKHRGLPHDAAKWRVFTSKLSHFSIQKSMA 224 Query: 142 HLVEDQVAEVTFVPVS-KVNGQVEVE----DILAAVRPTTCLVTIMLANNET--GVIMPI 194 L A +PV +++V+ ++ ++ V ++ + T G I P+ Sbjct: 225 ILGLGYDA---VIPVDYDERYRMDVDCLKQEVQRCLQQGLIPVAVVATSGTTDFGSIDPL 281 Query: 195 SEISRRIKALNQIRAASGLPRVLVHTDAAQALG------KRRVDVEDLGVDFLTIVGHKF 248 IS K + +H DAA G R D +T+ HK Sbjct: 282 GAISELCK----------HHGMWMHVDAAYGCGLLVSESHRPRLAGIEKADSVTVDYHKS 331 Query: 249 YGPRI--GALYVRGVGKLTPL 267 + + GA +VR L+ + Sbjct: 332 FFQTVSCGAFFVRDKHHLSHV 352 >3F9T-A nrPDB Length = 397 Score = 45.7 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 90/295 (30%), Gaps = 55/295 (18%) Query: 64 NTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTR 123 A A L ++ K SGGTE+N + + + E++ + Sbjct: 72 EKAVALLGSLLNNKDAYGHIVSGGTEANLMALRCIKNIWREKRRKGLSKNEH-------- 123 Query: 124 PHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRP-TTCLVTIM 182 P I H S E E E + P+ K + ++ + + AV + + Sbjct: 124 PKIIVPITAHFS----FEKGREMMDLEYIYAPI-KEDYTIDEKFVKDAVEDYDVDGIIGI 178 Query: 183 LANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRR------------ 230 E G I I E+S+ K N + +H DAA Sbjct: 179 AGTTELGTIDNIEELSKIAKENN----------IYIHVDAAFGGLVIPFLDDKYKKKGVN 228 Query: 231 --VDVEDLGVDFLTIVGHKFYG---PRIGALYVR-GVGKLTPLYPMLFGGGQERNFRPGT 284 D LGVD +TI HK P G L+ G + + ++ Sbjct: 229 YKFDFS-LGVDSITIDPHKMGHCPIPSGGILFKDIGYKRYLDVDAPYLTETRQATI---- 283 Query: 285 ENTPMIAGLGKAADLVSENCETYEAHMRDIRD------YLEERLEAEFGKRIHLN 333 G G A E + + + YL ++L+ K + Sbjct: 284 --LGTRVGFGGACTYAVLRYLGREGQRKIVNECMENTLYLYKKLKENNFKPVIEP 336 >5LUC-A nrPDB Length = 403 Score = 45.3 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 47/302 (15%), Positives = 93/302 (30%), Gaps = 53/302 (17%) Query: 145 EDQVAEVTFVPVSKVNG-QVEVEDILAAV-RPTTCLVTIMLANNETGVIMPISEISRRIK 202 E A V P++K G ++++ + + L+ + + TGV+ P+ Sbjct: 128 ERIGARVH--PMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCH 185 Query: 203 ALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGA------- 255 + L+ ++ +LG + ++ G+D L K G Sbjct: 186 R----------YKCLLLVNSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSD 235 Query: 256 -----LYVRGVG-----KLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAD-LVSENC 304 +Y R +G + T + L ++ + + Sbjct: 236 KAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGL 295 Query: 305 ETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQC 364 E R+ YL RL+A G ++ + RLP ++ GY Sbjct: 296 ENSWRQHREAAAYLHGRLQA-LGLQLFVKDP---ALRLPTVTTVAVPA----GYDWRDIV 347 Query: 365 QTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQA 424 ++ VL G+ +G + TR VD + + L+ A Sbjct: 348 SYVIDHFDIEIMGGLGPSTGKVLR-IGL------------LGCNATRENVDRVTEALRAA 394 Query: 425 VN 426 + Sbjct: 395 LQ 396 >1IBJ-A nrPDB Length = 464 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 77/423 (18%), Positives = 123/423 (29%), Gaps = 91/423 (21%) Query: 24 YNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIF 83 Y T +P I+ + GNP+ A SL + + F Sbjct: 109 YQTATFKQPSAIENGPYDYTRS-GNPTR-------------DALESLLAKLDKADRAFCF 154 Query: 84 TSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHL 143 TSG + S V + D G + S +P Sbjct: 155 TSG------MAALSAVTHLIKNGEEIVAGDD----VYGGSDRLL-------SQVVP---- 193 Query: 144 VEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKA 203 V V +++++ AA+ P T LV + T IS+I + + Sbjct: 194 --RSGVVVKRV------NTTKLDEVAAAIGPQTKLV---WLESPTNPRQQISDIRKISEM 242 Query: 204 LNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPR----IGALYVR 259 + A LV D + +E LG D + KF G L V+ Sbjct: 243 AHAQGA-------LVLVDNSIMSPVLSRPLE-LGADIVMHSATKFIAGHSDVMAGVLAVK 294 Query: 260 GVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLE 319 G +Y + G G L + ++ E + + R I YL Sbjct: 295 GEKLAKEVYFLQNSEG------SGLAPFDCWLCL-RGIKTMALRIEKQQENARKIAMYLS 347 Query: 320 ERLEAEFGKRIHLNSRFPGVERL------PNTCNFSIQGSQLRGYMVLAQCQ---TLLAS 370 K + L FS + L + ++ S Sbjct: 348 S--HPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVS 405 Query: 371 VGAS-------CHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQ 423 G+ C H P+ V + G+ D+ VR+S G +VD ++ DL Sbjct: 406 FGSVKSLISMPCFMSHASIPAEVREARGLTEDL----VRISAGI----EDVDDLISDLDI 457 Query: 424 AVN 426 A Sbjct: 458 AFK 460 >3DR4-A nrPDB Length = 391 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 50/339 (14%), Positives = 97/339 (28%), Gaps = 28/339 (8%) Query: 97 STVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPV 156 + ++ G I ++ + + + + A V Sbjct: 70 GVKHAIACNNGTTALHLALVAMGIGPGDEVIVPSLTYIASANSVTYC----GATPVLVDN 125 Query: 157 SKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRV 216 ++ + A + P T + + + + PI E++RR + Sbjct: 126 DPRTFNLDAAKLEALITPRTKAIMPVHLYGQICDMDPILEVARR-------------HNL 172 Query: 217 LVHTDAAQALGKR---RVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFG 273 LV DAA+A+G + + G+ G + L +L G Sbjct: 173 LVIEDAAEAVGATYRGKKSGSLGDCATFSFFGNAIITTGEGGMITTNDDDLAAKMRLLRG 232 Query: 274 GGQERNFRPGTENTP---MIAGLGKAADLVSENC--ETYEAHMRDIRDYLEERLEAEFGK 328 G + N R + + A L E A R + Y E++L + Sbjct: 233 QGMDPNRRYWFPIVGFNYRMTNIQAAIGLAQLERVDEHLAARERVVGWY-EQKLARLGNR 291 Query: 329 RIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSPVLL 388 + G +G V+ L H H P L Sbjct: 292 VTKPHVALTGRHVFWMYTVRLGEGLSTTRDQVIKDLDALGIESRPVFHPMHIMPPYAHLA 351 Query: 389 SCGIPVDVARNAVRLSVGRST--TRAEVDLIVQDLKQAV 425 + + + A L++ T A++D ++ L Q + Sbjct: 352 TDDLKIAEACGVDGLNLPTHAGLTEADIDRVIAALDQVL 390 >3FFH-A nrPDB Length = 363 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 33/157 (21%), Positives = 60/157 (38%), Gaps = 34/157 (21%) Query: 67 RASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHF 126 R +A + +++IFT+G E L L +D + P F Sbjct: 73 RKEVADFYQLEEEELIFTAGVDELIEL--------------LTRVLLDTTTNTVMATPTF 118 Query: 127 ITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANN 186 + +++ + AEV +P+ +G+ ++E +L A+ T +V I NN Sbjct: 119 V--QYRQNALI---------EGAEVREIPL-LQDGEHDLEGMLNAIDEKTTIVWICNPNN 166 Query: 187 ETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAA 223 TG + +++I + VLV D A Sbjct: 167 PTGNYIELADIQAFL--------DRVPSDVLVVLDEA 195 >1N8P-A nrPDB Length = 393 Score = 43.0 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 68/422 (16%), Positives = 123/422 (29%), Gaps = 76/422 (18%) Query: 30 LEPEVIQAV---TEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFTSG 86 + VI+ + T + + NP +Y R ++A + + + F+SG Sbjct: 21 VHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQ-YGLAFSSG 79 Query: 87 GTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVED 146 S Q QG I G + T Sbjct: 80 ----------SATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAH------------ 117 Query: 147 QVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQ 206 E +F + D+ ++ T LV I N T + I +++ IK Sbjct: 118 -GVETSFT-------NDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKK--- 166 Query: 207 IRAASGLPRVLVHTDAAQALGKR--RVDVEDLGVDFLTIVGHK-FYGPR---IGALYVRG 260 + V++ D ++ G D + K G +G L Sbjct: 167 ---HAAGQDVILVVDNTFLSPYISNPLNF---GADIVVHSATKYINGHSDVVLGVLATNN 220 Query: 261 VGKLTPLYPMLFG-GGQERNFRP-----GTENTPMIAGLGKAADLVSENCETY-EAHMRD 313 L + G F G + + L + + A + Sbjct: 221 KPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAA---LSANKIAEFLAADKEN 277 Query: 314 IRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQ--TLLASV 371 + L+ + L + +F I+G + + TL S+ Sbjct: 278 VVAVNYPGLKTHPNYDVVLKQHRDALG--GGMISFRIKGGAEAASKFASSTRLFTLAESL 335 Query: 372 GASCHSDHEDRPSPVLLSCGIPVDVARNA------VRLSVGRSTTRAEVDLIVQDLKQAV 425 G + V+ GIP + + VR+SVG + D +++D+KQA+ Sbjct: 336 GGI---ESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGI----EDTDDLLEDIKQAL 388 Query: 426 NQ 427 Q Sbjct: 389 KQ 390 >1O4S-A nrPDB Length = 389 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 65/419 (15%), Positives = 127/419 (30%), Gaps = 103/419 (24%) Query: 29 PLEPEVIQAVTEAMKE---AWGNPSSSYVAGRKAKDIINTARASLAKMIGGK------PQ 79 P V++ +++ + +P Y R +AK IG + P Sbjct: 54 PTPEPVVEEAVRFLQKGEVKYTDPRGIYEL-----------REGIAKRIGERYKKDISPD 102 Query: 80 DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLP 139 ++ T+G ++ + + E V I P I Sbjct: 103 QVVVTNGAKQALFNAFMALLDPGDEVIVFSPVWVSYI-------PQIILA---------- 145 Query: 140 LEHLVEDQVAEVTFVPVS-KVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMP---IS 195 V V N Q +E++ + T V I NN TGV+ + Sbjct: 146 --------GGTVNVVETFMSKNFQPSLEEVEGLLVGKTKAVLINSPNNPTGVVYRREFLE 197 Query: 196 EISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTI-----VGHKFYG 250 + R K N + + LV+TD ++ +DV + G D + H G Sbjct: 198 GLVRLAKKRNFYIISDEVYDSLVYTDEFTSI----LDVSE-GFDRIVYINGFSKSHSMTG 252 Query: 251 PRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAH 310 R+G Y+ K+ + T + A + + Sbjct: 253 WRVG--YLISSEKVATAVS---------KIQSHTTSCINTVAQYAALKALEVDNSYMVQT 301 Query: 311 MRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLAS 370 ++ ++++ ERL+ K + F F ++G ++ L + + + Sbjct: 302 FKERKNFVVERLKKMGVKFVEPEGAF--------YLFFKVRGDDVKFCERLLEEKKVALV 353 Query: 371 VGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE 429 G++ + VRLS S ++ + + L + + L Sbjct: 354 PGSAF--------------------LKPGFVRLSFATS-----IERLTEALDRIEDFLN 387 >1J32-A nrPDB Length = 388 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 73/247 (29%), Gaps = 11/247 (4%) Query: 141 EHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRR 200 E + + V + +V E I A+ P T L+ +N TG++ E+ Sbjct: 129 EMVKLAEGTPVILPTTVETQFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVYTPDEVRAI 188 Query: 201 IKALNQIRAASGLPRVL--VHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYV 258 + + + + D AQ L E + K Y A+ Sbjct: 189 AQVAVEAGLWVLSDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTY-----AMTG 243 Query: 259 RGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYL 318 VG L P++ + + T G A + + + A + R Y+ Sbjct: 244 WRVGFLAGPVPLVKAATKIQGHSTSNVCTFAQYGAIAAYENSQDCVQEMLAAFAERRRYM 303 Query: 319 EERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSD 378 + L A G P+ S L L + GA+ +D Sbjct: 304 LDALNAMPGLEC--PKPDGAFYMFPSIA--KTGRSSLDFCSELLDQHQVATVPGAAFGAD 359 Query: 379 HEDRPSP 385 R S Sbjct: 360 DCIRLSY 366 >3WKR-A nrPDB Length = 416 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 38/226 (16%), Positives = 69/226 (30%), Gaps = 45/226 (19%) Query: 30 LEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIG---GKPQDIIFTSG 86 L E +AV E I +AK + +P T G Sbjct: 66 LPKEAKKAVYEYWDGYSVCDYCHGRLDEVTCPPIKDFLEDIAKFLNMDCARP-----THG 120 Query: 87 GTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHL--- 143 E +V+H+ + + + H + + E Sbjct: 121 AREGKFIVMHAICK---------------------EGDYVVLDKNAHYTSYVAAERAKLN 159 Query: 144 VEDQVAEVTFVPVSKVN--GQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRI 201 V + E + P K+N G EV D L L+ + + E G + ++ + Sbjct: 160 VAEVGYEEEY-PTYKINLEGYKEVIDNLEDKGKNVGLILLTHVDGEYGNLNDAKKVGKIA 218 Query: 202 KALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHK 247 K + + A +G+ V+ +++ DF+ GHK Sbjct: 219 KEKG----------IPFLLNCAYTVGRMPVNGKEVKADFIVASGHK 254 >2Z9W-A nrPDB Length = 392 Score = 42.2 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 69/262 (26%), Gaps = 30/262 (11%) Query: 142 HLVEDQVAEVTFVPVSKVNGQVEVEDILAAVR--PTTCLVTIMLANNETGVIMPISEISR 199 + + + + V N ++ + + ++ P +V++ + +G I PI I Sbjct: 100 YWAKRYSPHLLEIEV-PYNEAIDPQAVADMLKAHPEITVVSVCHHDTPSGTINPIDAIGA 158 Query: 200 RIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVR 259 + A + DA + G + ED D +K G G + Sbjct: 159 LVSAHG----------AYLIVDAVSSFGGMKTHPEDCKADIYVTGPNKCLGAPPGLTMMG 208 Query: 260 ------GVGKLTPLYPM--------LFGGGQERNFRPGTENTPMIAGLGKAADLVSENCE 305 K PL P P T + I GL A DL Sbjct: 209 VSERAWAKMKANPLAPRASMLSIVDWENAWSRDKPFPFTPSVSEINGLDVALDLYLNEGP 268 Query: 306 TYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLA-QC 364 + G + S + T + G + A Sbjct: 269 EAVWARHALTAKAMRAGVTAMGLSVWAASD--SIASPTTTAVRTPDGVDEKALRQAARAR 326 Query: 365 QTLLASVGASCHSDHEDRPSPV 386 ++ S G R + Sbjct: 327 YGVVFSSGRGETLGKLTRIGHM 348 >2E54-A nrPDB Length = 385 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 63/328 (19%), Positives = 106/328 (32%), Gaps = 53/328 (16%) Query: 9 RGSVESPPNRKVYMDYNATTPL------EPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDI 62 +GS Y+D+ + + P +++A+ + ++ S + + Sbjct: 18 KGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEKLI---HCSNLFWNR--PQ 72 Query: 63 INTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGT 122 + A L+K + F + GTE+N I + ++ + R + + G Sbjct: 73 MELA-ELLSK--NTFGGKVFFANTGTEANEAAIKIARKYGKKKSEKKYRILSAHNSFHGR 129 Query: 123 RPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIM 182 +T T + + P E L VP + VED+ + C V + Sbjct: 130 TLGSLTATGQ-PKYQKPFEPL----------VPGFEYFEFNNVEDLRRKMSEDVCAVFLE 178 Query: 183 LANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQA----LGKRRVDVEDLGV 238 E+G++ E + L A L+ D Q GK + GV Sbjct: 179 PIQGESGIVPATKEFLEEARKLCDEYDA------LLVFDEVQCGMGRTGKL-FAYQKYGV 231 Query: 239 --DFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFG---GGQERNFRPGTENTPMIAGL 293 D LT G IGA+ V + L P G GG R G Sbjct: 232 VPDVLTTAKGLGGGVPIGAVIVNERANV--LEPGDHGTTFGGNPLACRAGVTVIK----- 284 Query: 294 GKAADLVSEN-CETYEAHMRDIRDYLEE 320 +L E E E + L+E Sbjct: 285 ----ELTKEGFLEEVEEKGNYLMKKLQE 308 >4CVQ-A nrPDB Length = 431 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 79/243 (32%), Gaps = 31/243 (12%) Query: 148 VAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPIS---EISRRIKAL 204 V ++ + +++DI A + P T + I+ NN TG + EI + Sbjct: 167 GKAVHYLCDESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQH 226 Query: 205 NQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIV------GHKFYGPRIGALYV 258 N I A + +++ DA + L D LTI ++ G R G + + Sbjct: 227 NLIIFADEIYDKILYDDAEHH------SIAPLAPDLLTITFNGLSKTYRVAGFRQGWMVL 280 Query: 259 RGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAA-------DLVSENCETYEAHM 311 G K + G + R N P + A + ++ + Sbjct: 281 NGPKK--HAKGYIEGLEMLASMRL-CANVPAQHAIQTALGGYQSISEFITPG-----GRL 332 Query: 312 RDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASV 371 + R+ E + G + + F+I Q L Q + LL Sbjct: 333 YEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDDQKMVLDFLLQEKVLLVQ- 391 Query: 372 GAS 374 G + Sbjct: 392 GTA 394 >3QI6-A nrPDB Length = 392 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 94/289 (32%), Gaps = 32/289 (11%) Query: 147 QVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQ 206 V + PV +++ + AA+RPTT L+ + N I I+ I++ Sbjct: 127 TGWNVEYTPV----ALADLDAVRAAIRPTTRLIWVETPTNPLLSIADIAGIAQL------ 176 Query: 207 IRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRI----GALYVRGVG 262 A +VLV A ++ + LG D + K+ G GAL Sbjct: 177 --GADSSAKVLVDNTFASPALQQPLS---LGADVVLHSTTKYIGGHSDVVGGALVTNDEE 231 Query: 263 KLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRD---IRDYLE 319 + G G + L SEN + + I L Sbjct: 232 LDQSFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLY 291 Query: 320 ERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLA--QCQTLLASVGASCHS 377 L + G + + + ++ + + A L S+G+ Sbjct: 292 PGLPSHPGHAVAAR----QMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGSVESL 347 Query: 378 DHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVN 426 + G ++V + VRLSVG +V ++ DLKQA+ Sbjct: 348 IEHPSAMTHASTAGSQLEVPDDLVRLSVGI----EDVADLLDDLKQALG 392 >1U08-A nrPDB Length = 386 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 27/193 (13%), Positives = 55/193 (28%), Gaps = 25/193 (12%) Query: 32 PEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFTSGGTESN 91 P +Q N + + ++ I L DI T+G TE+ Sbjct: 45 PRYLQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEAL 104 Query: 92 NLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEV 151 I + VR E + P V Sbjct: 105 YAAITALVRNGDEVICFDPSY-------DSYAPAIALS------------------GGIV 139 Query: 152 TFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAAS 211 + + + +V+ ++ A + T LV + +N + + ++ + +A+ Sbjct: 140 KRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFV 199 Query: 212 GLPRVLVHTDAAQ 224 V H + +Q Sbjct: 200 ISDEVYEHINFSQ 212 >2GB3-A nrPDB Length = 409 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 76/244 (31%), Gaps = 42/244 (17%) Query: 41 AMKEAWGN----PSSSYVAG-RKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVI 95 + + N S+ AG + ++ + + + KP++++ T+GG+E+ Sbjct: 61 FFERIYENKPEVVYYSHSAGIWELREAF-ASYYKRRQRVDVKPENVLVTNGGSEAILFSF 119 Query: 96 HSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVP 155 D+I E + + A V +P Sbjct: 120 AVIAN-----------PGDEILVLEPF-----------YANYNAFAKI-----AGVKLIP 152 Query: 156 VSK--VNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIR----A 209 V++ G +++ + + T + + N TGV+ E+ ++ + Sbjct: 153 VTRRMEEGFAIPQNLESFINERTKGIVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIV 212 Query: 210 ASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYP 269 ++ + A AL V + G R+G L R ++ Sbjct: 213 DEVYSEIVFRGEFASALSIESDKVVVIDSVSKKFSA---CGARVGCLITRNEELISHAMK 269 Query: 270 MLFG 273 + G Sbjct: 270 LAQG 273 >3FFR-A nrPDB Length = 362 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 53/339 (15%), Positives = 95/339 (28%), Gaps = 72/339 (21%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIG 75 N K+Y + L P V Q + A+ E G S +K +++ TA +L ++ Sbjct: 2 MNNKIYF-TPGPSELYPTVRQHMITALDEKIGVIS---HRSKKFEEVYKTASDNLKTLLE 57 Query: 76 -GKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHD 134 +++F + TE +I + V + Sbjct: 58 LPSNYEVLFLASATEIWERIIQNCVEKKSFHCVNGSFSKRFYEFAGELGREA-------- 109 Query: 135 SIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPI 194 E+ F P V ++ + +GV MP+ Sbjct: 110 --------YKEEAAFGKGFYPADI------------TVPADAEIICLTHNETSSGVSMPV 149 Query: 195 SEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIG 254 +I+ L+ DA +L + D + F ++ K +G G Sbjct: 150 EDINTF---------RDKNKDALIFVDAVSSLPYPKFDWTKIDSVFFSV--QKCFGLPAG 198 Query: 255 ---------------ALYVRGVGKLT-PLYPMLFGGGQERNFRPGTENTPMIAGL----- 293 AL + T P + E+ T TP + Sbjct: 199 LGVWILNDRVIEKSKALLAKRKSIGTYHTIPSML----EKARVNQTPETPNAMNIFLLGK 254 Query: 294 --GKAADLVSENC-ETYEAHMRDIRDYLEERLEAEFGKR 329 G + ++ + E I Y+E FG Sbjct: 255 VTGDMLQISADGIRKQTEEKAALINTYIESSKVFSFGVE 293 >2DGM-A nrPDB Length = 466 Score = 36.4 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 81/277 (29%), Gaps = 34/277 (12%) Query: 84 TSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHL 143 T G +E+ L + + ++ G+ D +P+ + V+ + Sbjct: 123 TIGSSEACMLGGMAMKWRWRKRMEAAGKPTD--------KPNLVCGPVQ-----ICWHKF 169 Query: 144 VEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKA 203 E+ +P+ ++ + ++ A T V TG E + + Sbjct: 170 ARYWDVELREIPMRPGQLFMDPKRMIEACDENTIGVVPTFGVTYTGNY----EFPQPLHD 225 Query: 204 LNQIRAASGLPRVLVHTDAAQA-------LGKRRVDVEDLGVDFLTIVGHKFYGPRIGAL 256 A + +H DAA D V ++ GHKF +G Sbjct: 226 ALDKFQADTGIDIDMHIDAASGGFLAPFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCG 285 Query: 257 YVRGVGKLTPLYPMLFG----GGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMR 312 +V + ++F GGQ F + + + + E Y Sbjct: 286 WVIWRDEEALPQELVFNVDYLGGQIGTFAINFSRPAGQV-IAQYYEFLRLGREGYTKVQN 344 Query: 313 ---DIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTC 346 + YL + + R E +P C Sbjct: 345 ASYQVAAYLADEIAKLGPYEFICTGRPD--EGIPAVC 379 >6F35-A nrPDB Length = 410 Score = 36.0 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 94/280 (33%), Gaps = 44/280 (15%) Query: 162 QVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLV--- 218 ++ E + AA+ P T V + +N +G ++ ++ L + L + Sbjct: 161 RLTAEKLEAAITPRTRWVLLNSPSNPSGAAYSAADYRPLLEVLLRHPHVWLLVDDMYEHI 220 Query: 219 HTDAAQALGKRRVDVED-LGVDFLTIVG----HKFYGPRIGALYVRGVGKLTPLYPMLFG 273 D + + +E L LT+ G + G RIG Y G +L ++ Sbjct: 221 VYDGFRFV--TPAQLEPGLKNRTLTVNGVSKAYAMTGWRIG--YAGGPRELIKAMAVVQ- 275 Query: 274 GGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLN 333 Q + + L D + E E+++ RD + L A G Sbjct: 276 -SQATSCPSSISQAASVVALNGPQDFLKERTESFQRR----RDLVVNGLNAIDGLDC--- 327 Query: 334 SRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRP-----SPVLL 388 R+P ++ G A + G +D + + V + Sbjct: 328 -------RVPEGAFYTFSGC--------AGVLGKVTPSGKRIKTDTDFCAYLLEDAHVAV 372 Query: 389 SCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 G ++ R+S T+ AE+ ++ + A ++L Sbjct: 373 VPGSAFGLSP-FFRISYA--TSEAELKEALERIAAACDRL 409 >1GC4-A nrPDB Length = 385 Score = 35.3 bits (79), Expect = 0.049, Method: Composition-based stats. Identities = 12/79 (15%), Positives = 25/79 (31%) Query: 141 EHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRR 200 E + V + + + E + A+ P T + + NN TG + P + Sbjct: 130 EMVRFAGGVVVEVETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEAL 189 Query: 201 IKALNQIRAASGLPRVLVH 219 + + + H Sbjct: 190 ARLAVEHDFYLVSDEIYEH 208 >5HSI-A nrPDB Length = 634 Score = 35.3 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 33/224 (14%), Positives = 70/224 (31%), Gaps = 24/224 (10%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTAR--ASLAKM 73 N Y AT+ +E EV Q M +G + + AR SL Sbjct: 119 GNNVAYESSPATSQMEEEVGQEFARLMGYDYGWGHIVADGSLANLEGLWYARNIKSLPFA 178 Query: 74 IGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHF---ITCT 130 + +++ E N+ + + + + + Sbjct: 179 MKEVNPELVAGKSDWELLNMPTKEIMDLLENAGSQIDEVKKRSARSGKNLQRLGKWLVPQ 238 Query: 131 VEHDSIRLPLEHLVEDQVA---EVTFVPVSKVNGQVEVEDILAAVR----PTTCLVTIML 183 +H S + +V VP+ N +++++ + + +R T ++ ++ Sbjct: 239 TKHYS----WMKAADIIGIGLDQVVPVPIDS-NYRMDIQALESIIRKYAAEKTPILGVVG 293 Query: 184 A--NNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQA 225 + E G + I +I + L + +H DAA Sbjct: 294 VAGSTEEGAVDGIDKIVALRQKLQKEGIYF-----YLHVDAAYG 332 >3NYS-A nrPDB Length = 367 Score = 35.3 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 62/178 (34%), Gaps = 43/178 (24%) Query: 50 SSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQ 109 Y+ G + ++ LA +G K I + GT++ +V Sbjct: 28 HGQYILGPEVTEL----EDRLADFVGAK--YCISCANGTDALQIV--------------- 66 Query: 110 GRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDIL 169 Q++ G IT + + + L A+ +V + ++ + + Sbjct: 67 -----QMALGVGPGDEVITPGFTYVATAETVALL----GAKPVYVDIDPRTYNLDPQLLE 117 Query: 170 AAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALG 227 AA+ P T I+P+S + + + I A + + V DAAQ+ G Sbjct: 118 AAITPRTK------------AIIPVS-LYGQCADFDAINAIASKYGIPVIEDAAQSFG 162 >4ZWV-A nrPDB Length = 372 Score = 34.5 bits (77), Expect = 0.089, Method: Composition-based stats. Identities = 7/69 (10%), Positives = 26/69 (37%), Gaps = 4/69 (5%) Query: 115 QISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRP 174 ++ R ++ + ++ + +T+V V ++++D+ + P Sbjct: 66 RLLDAPEERDEVLSTPLTFEAT----NWAILADGRRITWVDVDPATLTMDLDDLERKISP 121 Query: 175 TTCLVTIML 183 T + ++ Sbjct: 122 ATRAIIVVH 130 >3VOM-A nrPDB Length = 398 Score = 34.5 bits (77), Expect = 0.094, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 22/62 (35%), Gaps = 11/62 (17%) Query: 181 IMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDF 240 I A+NET + ++ +R G LV DA G VD+ + + Sbjct: 169 IAWAHNETSTGVAVA-----------VRRPEGSDDALVVIDATSGAGGLPVDIAETDAYY 217 Query: 241 LT 242 Sbjct: 218 FA 219 >2O0R-A nrPDB Length = 411 Score = 34.5 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 76/252 (30%), Gaps = 37/252 (14%) Query: 80 DIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLP 139 +++ T G TE+ + V G V I P + + H R+ Sbjct: 88 EVLVTVGATEAIAAAVLGLVE--------PGSEVLLIEPFYDSYSPVVAMAGAH---RVT 136 Query: 140 LEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISR 199 + + + + + + + + AV P T + I +N TG ++ +E++ Sbjct: 137 VPLVPDGRGFAL------------DADALRRAVTPRTRALIINSPHNPTGAVLSATELAA 184 Query: 200 RIKALNQIRAASGLPRVLVHT--DAAQALGKRRVDVEDLGVDFLTIVGHKFY---GPRIG 254 + V H D A+ L D K + G +IG Sbjct: 185 IAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFD-GMAERTITISSAAKMFNCTGWKIG 243 Query: 255 ALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDI 314 + G +L + Q ++ G P + A D +R Sbjct: 244 --WACGPAELI---AGVRAAKQYLSYVGGAPFQP---AVALALDTEDAWVAALRNSLRAR 295 Query: 315 RDYLEERLEAEF 326 RD L L Sbjct: 296 RDRLAAGLTEIG 307 >2CY8-A nrPDB Length = 453 Score = 33.7 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 43/108 (39%), Gaps = 16/108 (14%) Query: 8 ARGSVESPPNRKVYMDYNATTPL------EPEVIQAVTEAMKEAWGNPSSSYVAGRKAKD 61 A+G ++ + VY+D+ P V A+ EA+ ++S+ + + Sbjct: 46 AQGVHKTDVDGNVYLDFFGGHGALVLGHGHPRVNAAIAEALSHGV-QYAASHPLEVRWAE 104 Query: 62 IINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQ 109 I A S+ K+ FT GTE+ L+ R F ++ + Sbjct: 105 RIVAAFPSIRKLR--------FTGSGTET-TLLALRVARAFTGRRMIL 143 >1PFF-A nrPDB Length = 331 Score = 33.3 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 55/342 (16%), Positives = 103/342 (30%), Gaps = 44/342 (12%) Query: 99 VRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSK 158 + G + H I+ + EH + EV F+ + Sbjct: 13 AEACAATASGMGAIAASVWTFLKAGDHLISDDCLYGCTHALFEHQLRKFGVEVDFIDM-A 71 Query: 159 VNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLV 218 V G +I ++P T +V N T ++ I + ++ + +LV Sbjct: 72 VPG-----NIEKHLKPNTRIVYFETPANPTLKVIDIEDAVKQARKQKD---------ILV 117 Query: 219 HTDAAQALGKRRVDVEDLGVDFLTIVGHKF---YGPRIGALYVRGVGKLTPLYPM----- 270 D A + DLGVD + K+ + + L + + Sbjct: 118 IVDNTFASP-ILTNPLDLGVDIVVHSATKYINGHTDVVAGLVCSRADIIAKVKSQGIKDI 176 Query: 271 ---LFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFG 327 + GT M +AA+ + E H + Y L G Sbjct: 177 TGAIISPHDAWLITRGTLTLDMRV--KRAAENAQKVAEFLHEHKAVKKVY-YPGLPDHPG 233 Query: 328 KRIHLNSRFPGVERLPNTCNFSIQGSQ-LRGYMVLAQCQTLLASVGASCHSDHEDRPSPV 386 I ++ + F + G + + + +L S+G + + Sbjct: 234 HEI----AKKQMKMFGSMIAFDVDGLEKAKKVLDNCHVVSLAVSLGG---PESLIQHPAS 286 Query: 387 LLSCGIPVDVARNA------VRLSVGRSTTRAEVDLIVQDLK 422 + G+P + A +RLSVG + +D + Q L Sbjct: 287 MTHAGVPKEEREAAGLTDNLIRLSVGCENVQDIIDDLKQALD 328 >4PIW-A nrPDB Length = 396 Score = 32.2 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 47/144 (32%), Gaps = 24/144 (16%) Query: 148 VAEVTFVPVSKVNGQVEVEDILAAVRPTTC-LVTIMLANNETGVIMPISEISRRIKALNQ 206 A++ FV V ++ I AA+ T +V + A GV + I K N Sbjct: 112 GAKIVFVDVRPDTMNIDETLIEAAITDKTRVIVPVHYA----GVACEMDTIMALAKKHN- 166 Query: 207 IRAASGLPRVLVHTDAAQAL-----GKRRVDVEDLGVDFLTIVGHKFY--GPRIGALYVR 259 + V DAAQ + G+ + +G + K Y G GA + Sbjct: 167 ---------LFVVEDAAQGVMSTYKGRALGTIGHIGC--FSFHETKNYTAGGEGGATLIN 215 Query: 260 GVGKLTPLYPMLFGGGQERNFRPG 283 + + G F G Sbjct: 216 DKALIERAEIIREKGTNRSQFFRG 239 >6BLG-A nrPDB Length = 379 Score = 31.8 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 71/232 (30%), Gaps = 33/232 (14%) Query: 148 VAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQI 207 A++ FV + + ++ I AA+ T I+P+ ++ I Sbjct: 95 GAKIVFVDIRRDTMNIDETLIEAAITDKTR------------AIVPVHYAGVAC-EMDTI 141 Query: 208 RAASGLPRVLVHTDAAQAL-----GKRRVDVEDLGVDFLTIVGHKFY--GPRIGALYVRG 260 A + + V DAAQ + G+ + +G + K Y G GA + Sbjct: 142 MAIADKYNLFVVEDAAQGVMSTYKGRALGTIGHIGC--FSFHETKNYTAGGEGGATLIND 199 Query: 261 VGKLTPLYPMLFGGGQERNFRPGTEN--TPMIAG-------LGKAADLVSENCET--YEA 309 + + G F G + T G L A + Sbjct: 200 RTLVERAEIIREKGTNRSQFFRGLVDKYTWRDIGSSYLMSDLQAAYLWAQLEAAERINQQ 259 Query: 310 HMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVL 361 + ++Y + L RI L + + + ++ + R ++ Sbjct: 260 RLALWQNYYDALLPLARAGRIELPTVPADCGQNAHMFYIKLRDIEDRSRLIA 311 >4BMK-A nrPDB Length = 442 Score = 31.8 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 63/204 (30%), Gaps = 42/204 (20%) Query: 27 TTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKPQDIIFTSG 86 +P+VI A EA+++ + S + D + +L G I+F++G Sbjct: 98 GMTFDPDVIAAGKEALEKFGSGTNGSRMLNGTFHDHME-VEQALRDFYGTT-GAIVFSTG 155 Query: 87 GTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVED 146 + IS G + I H SI + Sbjct: 156 ----------------------YMANLGIISTLAGKGEYVILDADSHASIYDG----CQQ 189 Query: 147 QVAEVTFVPVSKVNGQVEVED-ILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALN 205 AE+ + N +++ + + LV + + G I P+ E+ K Sbjct: 190 GNAEIVRF---RHNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKK-- 244 Query: 206 QIRAASGLPRVLVHTDAAQALGKR 229 +V D A ++G Sbjct: 245 --------HGAMVLVDEAHSMGFF 260 >5K8B-A nrPDB Length = 403 Score = 31.8 bits (70), Expect = 0.65, Method: Composition-based stats. Identities = 36/247 (14%), Positives = 71/247 (28%), Gaps = 37/247 (14%) Query: 116 ISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPT 175 ++ G I + + A F + + + E I A + P Sbjct: 70 MAAGIGAGDEVIVPPFTFVASVEAIFMA----GAVPIFAEIDE-TLCLSPEGIEAVITPR 124 Query: 176 TCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQAL-----GKRR 230 T + ++ G + + EI K N +++ DA QA+ G+ Sbjct: 125 TKAINLVHM---CGSMAKMDEIKAICKKHN----------LVLLEDACQAIGGSYKGQAL 171 Query: 231 VDVEDLGVDFLTIVGHK--FYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTP 288 + D+G + K G GA+ + G G E+ P Sbjct: 172 GTIGDVGC--YSFDSVKTITCGEG-GAVITNNTEIYDNAHMFSDHGHDHIGKDRGAESHP 228 Query: 289 M------IAGLGKAADLVSE-NCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVER 341 + I+ + A L +T R + +++ + + G Sbjct: 229 IMGLNFRISEMNAALGLAQLRKLDTIIDIQRKNKKAIKDAMASIPEVSFREIPDPEG--D 286 Query: 342 LPNTCNF 348 +F Sbjct: 287 SAGFLSF 293 >3TEJ-A nrPDB Length = 329 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 15/35 (42%) Query: 232 DVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTP 266 DV+D DF + GH ++ A R V + Sbjct: 27 DVQDADADFFALGGHXLLAMKLAAQLSRQVARQVT 61 >1ZEJ-A nrPDB Length = 293 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 22/53 (41%), Gaps = 2/53 (3%) Query: 146 DQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEIS 198 +V +T P+ + V+DI + + + + N +MP+ EI Sbjct: 93 REVERLTNAPLCSNTSVISVDDIAERLDSPSRFLGVHWMNPP--HVMPLVEIV 143 >1MDZ-A nrPDB Length = 393 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 50/341 (14%), Positives = 92/341 (26%), Gaps = 36/341 (10%) Query: 106 QTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEV 165 G + ++ G IT ++ S + L A V V + V Sbjct: 62 SATAGMHIALMALGIGEGDEVITPSMTWVSTLNMIVLL----GANPVMVDVDRDTLMVTP 117 Query: 166 EDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQA 225 E I AA+ P T + + + I + R + V DAA A Sbjct: 118 EHIEAAITPQTKAIIPVHYAGAPADLDAIYALGER-------------YGIPVIEDAAHA 164 Query: 226 LG--KRRVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLT-PLYPMLFG--GGQERNF 280 G + + G + K G + V + L + F G + Sbjct: 165 TGTSYKGRHIGARGTAIFSFHAIKNITCAEGGIVVTDNPQFADKLRSLKFHGLGVDAWDR 224 Query: 281 RP-GTENTPMIAG---------LGKAADLVS-ENCETYEAHMRDIRDYLEERLEAEFGKR 329 + G + L A L + + A I + + + Sbjct: 225 QSGGRAPQAEVLAPGYKYNLPDLNAAIALAQLQKLDALNARRAAIAAQYHQAMADLPFQP 284 Query: 330 IHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDR-PSPVLL 388 + L S + ++A +T G + H + Sbjct: 285 LSLPSWEHIHAWHLFIIRVDEARCGITRDALMASLKTKGIGTGLHFRAAHTQKYYRERFP 344 Query: 389 SCGIPVDVARNAVRLSVGRS--TTRAEVDLIVQDLKQAVNQ 427 + +P + S+ T ++ D ++ L Q Q Sbjct: 345 TLTLPDTEWNSERICSLPLFPDMTESDFDRVITALHQIAGQ 385 >6FYQ-A nrPDB Length = 484 Score = 30.6 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 63/430 (14%), Positives = 120/430 (27%), Gaps = 65/430 (15%) Query: 16 PNRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIG 75 + +V + A ++ + + I A +A + Sbjct: 96 GHGRVELAEAAAQQMKKMAFSSAFSTFSH---------------EPAIRLA-EKIASITP 139 Query: 76 GKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDS 135 + FTSGG+ESN+ + + Q R + + T Sbjct: 140 EGLNAVFFTSGGSESNDSAVKLVRHYWKIQGKPNKRKIISLKRSYHGVAAASTSVT---G 196 Query: 136 IRLPLEHLVEDQV----AEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVI 191 I + + ++ Q + I A T GVI Sbjct: 197 IPEFWGMAGHMMTDFLHVDTHYNNTTEQAVQSLCQAIEEAGPETIAAFFAEPVQGAGGVI 256 Query: 192 MPISEISRRIKALNQIRAASGLPRVLVHTD----AAQALGKRRVDVEDLGV--DFLTIVG 245 +P + RI+ + +L D GK +E+ V D +T Sbjct: 257 IPPEDYFLRIREVCN------AYGILFVADEVITGFGRTGKM-FGIENWDVIPDVMTFAK 309 Query: 246 HKFYG--PRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSEN 303 G P G + + ++ + G F T L A + E Sbjct: 310 GVTSGYFPLGGVVVSDPIHEVLKEKSV---GTLFHGFTYSGHPTAAAVALKNIAIIKEER 366 Query: 304 CETYEAHMRDI----RDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYM 359 M D ++ RLE R + + P T Sbjct: 367 LVENSKRMGDALLHGLKKVKNRLEIVGDVRFVGLLGAVELMQNPAT-----NKPFSSNLQ 421 Query: 360 VLAQCQTLLASVGASCHSDHEDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQ 419 V + L +G C S D + + L+ + ++ + +VD +V+ Sbjct: 422 VAPKVIEALHELGVICRSVTYDHTNIICLAPPLIIN---------------QKQVDKLVE 466 Query: 420 DLKQAVNQLE 429 + +A+ +++ Sbjct: 467 VIYEAILKVQ 476 >2VUU-A nrPDB Length = 352 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 60/204 (29%), Gaps = 19/204 (9%) Query: 25 NATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGGKP-QDIIF 83 NAT +I+ S + I ++ P D +F Sbjct: 12 NATGRQAASLIRVAAAVGHHVRAQVHSLKGLIAEELQAIPNVTLFQGPLLNNVPLMDTLF 71 Query: 84 TSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHL 143 E +L +T ++ + D + GT H+I ++ S+ P + Sbjct: 72 -----EGAHLAFINTTSQAGDEIAIGKDLADA-AKRAGTIQHYIYSSMPDHSLYGPWPAV 125 Query: 144 VEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKA 203 + P V + P+T + + NN T + P+ ++ Sbjct: 126 PM-------WAPKFTVE-----NYVRQLGLPSTFVYAGIYNNNFTSLPYPLFQMELMPDG 173 Query: 204 LNQIRAASGLPRVLVHTDAAQALG 227 + A L DA +G Sbjct: 174 TFEWHAPFDPDIPLPWLDAEHDVG 197 >2QMA-A nrPDB Length = 497 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 7/93 (7%) Query: 82 IFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIR--LP 139 IFTSGGT+SN + + R + + P+ + + H +++ Sbjct: 162 IFTSGGTQSNQMGLM-LARDWIADKLSGHSIQKLGLPDYADKLRIVCSKKSHFTVQKSAS 220 Query: 140 LEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAV 172 L E V V + +G +++ + + Sbjct: 221 WMGLGEKAVMTVD----ANADGTMDITKLDEVI 249 >4OTL-A nrPDB Length = 423 Score = 30.2 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 45/124 (36%), Gaps = 16/124 (12%) Query: 206 QIRAASGLPRVLVHTDAAQ-----ALGKRRVDVEDLGVDFLTIVGHK-FYGPRIGALYVR 259 ++ + + D A A G V DF+T HK GPR G + ++ Sbjct: 194 RLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPH--ADFVTTTTHKSLRGPRGGVILMK 251 Query: 260 GVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAA-DLVSENCETYEAHMRDIRDYL 318 + P+ +F G Q G +IA A + +S + Y+ + + L Sbjct: 252 AEYE-KPINSAIFPGIQ------GGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVL 304 Query: 319 EERL 322 E L Sbjct: 305 AETL 308 >5WSC-A nrPDB Length = 475 Score = 30.2 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 65/195 (33%), Gaps = 20/195 (10%) Query: 37 AVTEAMKEAWGNPSSSY-----VAGRKAKDIINTAR-----ASLAKMIGG-KPQDIIFT- 84 A E ++ G S+ R A+D + R +A ++ + D++ T Sbjct: 89 AEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTV 148 Query: 85 -SGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHL 143 GG S+N I + D V + + + Sbjct: 149 VEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEV 208 Query: 144 VEDQVAEVTFVPVSKVNGQVE-VEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIK 202 ++ V + + ++ +E I+ A +M+A + GV +P+ E+ K Sbjct: 209 MDRIGRRVPVIAKLEKPEAIDNLEAIVLAFD------AVMVARGDLGVELPLEEVPLVQK 262 Query: 203 ALNQIRAASGLPRVL 217 Q+ + P ++ Sbjct: 263 RAIQMARENAKPVIV 277 >3NRA-A nrPDB Length = 407 Score = 30.2 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 14/102 (13%), Positives = 34/102 (33%), Gaps = 1/102 (0%) Query: 109 QGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQV-AEVTFVPVSKVNGQVEVED 167 QG ++ ++ + R +E + V ++ +V + +++ Sbjct: 112 QGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEGEMVPVQLDYVSADETRAGLDLTG 171 Query: 168 ILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRA 209 + A + + NN GV+ EI + + A Sbjct: 172 LEEAFKAGARVFLFSNPNNPAGVVYSAEEIGQIAALAARYGA 213 >1ZKI-A nrPDB Length = 133 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 32/103 (31%), Gaps = 10/103 (9%) Query: 302 ENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVL 361 A + I Y E G RLP + +G + G + Sbjct: 1 NGMSEMPAREQMISAYSE-----LVGLDPVSLGDGVAEVRLPMAAHLRNRGGVMHGGALF 55 Query: 362 AQCQTLLASVGASCHSDHEDRPSPVLLSCGIP--VDVARNAVR 402 + + ++G +C S H V L C I VA VR Sbjct: 56 S---LMDVTMGLACSSSHGFDRQSVTLECKINYIRAVADGEVR 95 >1VCN-A nrPDB Length = 550 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 22/71 (30%), Gaps = 1/71 (1%) Query: 57 RKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQI 116 R A+ + R +A +P +F+S E V + + ++ + Sbjct: 222 RSARPVPEEVRRKVALFTNVRPGH-VFSSPTVEHLYEVPLLLEEQGLGRAVERALGLEAV 280 Query: 117 SPEEGTRPHFI 127 P + Sbjct: 281 IPNLSFWQEAV 291 >2BKA-A nrPDB Length = 242 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 32/85 (37%), Gaps = 3/85 (3%) Query: 165 VEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQ 224 + + R V I+ A+ ETG ++ + EI + L G ++ +A + Sbjct: 7 LSKLREDFRMQNKSVFILGASGETGRVL-LKEILE--QGLFSKVTLIGRRKLTFDEEAYK 63 Query: 225 ALGKRRVDVEDLGVDFLTIVGHKFY 249 + + VD E L GH Sbjct: 64 NVNQEVVDFEKLDDYASAFQGHDVG 88 >2FMU-A nrPDB Length = 248 Score = 29.9 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 33/85 (38%), Gaps = 3/85 (3%) Query: 165 VEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQ 224 + + + V I+ A+ ETG ++ + EI + L G ++ +A + Sbjct: 13 LPKLREDFKMQNKSVFILGASGETGKVL-LKEI--LGQNLFSKVTLIGRRKLTFEEEAYK 69 Query: 225 ALGKRRVDVEDLGVDFLTIVGHKFY 249 + + VD E L V GH Sbjct: 70 NVNQEVVDFEKLDVYASAFQGHDVG 94 >5VMK-A nrPDB Length = 462 Score = 29.5 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 78/241 (32%), Gaps = 15/241 (6%) Query: 140 LEHLVEDQV---AEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISE 196 E A +PV +G + + T L ++ +N+TG+ M Sbjct: 78 WVEQAEQLGTGHAVQMTLPVLPKDGISLILYGDVPLVRQTTLEQLIEVSNKTGIGMITLH 137 Query: 197 ISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYG--PRIG 254 + +R + ++ H DA +A + ++++ + K + P++ Sbjct: 138 VDNPTGYGRIVRQDGKIQAIVEHKDATEAQRQ----IQEINTGIYCVSNAKLHEWLPKLS 193 Query: 255 ALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTP-MIAGLGKAADLVSENCETYEAHMRD 313 +G LT + M G E + G+ L + E + ++ Sbjct: 194 NENAQGEYYLTDIVAMAVADGLE--IASIQPELAFEVEGVNDRLQLAALEREFQKQQAKE 251 Query: 314 IRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGA 373 + +++ + R L + N I+G+ G V +L + Sbjct: 252 L---MQQGVTFADPARFDLRGTVKVGHDVRIDVNVIIEGNCELGDFVEIGAGCILKNTTI 308 Query: 374 S 374 + Sbjct: 309 A 309 >6F77-B nrPDB Length = 400 Score = 29.5 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 23/69 (33%) Query: 141 EHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRR 200 E + V + N +++ ED+ A+ P T +N +G E+ Sbjct: 130 EMVALCGGTPVFVPTRQENNFKLKAEDLDRAITPKTKWFVFNSPSNPSGAAYSHEELKAL 189 Query: 201 IKALNQIRA 209 L + Sbjct: 190 TDVLMKHPH 198 >4EVZ-A nrPDB Length = 258 Score = 28.3 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 36/104 (34%), Gaps = 13/104 (12%) Query: 119 EEGTRPHFITCTVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCL 178 EEG R + +VE +V F+P++ G VED +R Sbjct: 41 EEGADELVFLDITASHEGRETMLEVVERTAEQV-FIPLTVGGGIRSVEDASRLLRAGADK 99 Query: 179 VTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDA 222 V+I N V P + + + G V+V DA Sbjct: 100 VSI----NTAAVKNP--------ELITEAAEEFGSQAVVVAIDA 131 >5W25-A nrPDB Length = 616 Score = 28.3 bits (61), Expect = 6.7, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 21/45 (46%) Query: 56 GRKAKDIINTARASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVR 100 G AK++ R LA +G KP D IF S G ++ + R Sbjct: 380 GPVAKNLTEAERTGLADHVGAKPGDCIFFSAGPVKSSRALLGAAR 424 >5DDW-A nrPDB Length = 523 Score = 28.3 bits (61), Expect = 7.6, Method: Composition-based stats. Identities = 20/151 (13%), Positives = 36/151 (23%), Gaps = 31/151 (20%) Query: 292 GLGKAADLVSENCETYE-----AHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTC 346 GL + L + +R+ LE LE+ Sbjct: 379 GLSASIALKVLEMVEADGGRVYQRVRERGQRLEAMLESVRADH----------------- 421 Query: 347 NFSIQGSQLRGYMVLAQCQTLLASVGASCHS-DHEDRPSPVLLSC--------GIPVDVA 397 + + G M+ + + + + VL +P Sbjct: 422 SDVVSAVWGTGLMLALELRDQSNATSQAIREKAAHGFLGYVLAGFLLREHHIRVLPAGPR 481 Query: 398 RNAVRLSVGRSTTRAEVDLIVQDLKQAVNQL 428 +R S T E+D L+ L Sbjct: 482 SGFLRFSPSLYITDEEIDRTETALRSLFTAL 512 >1YQG-A nrPDB Length = 263 Score = 27.9 bits (60), Expect = 8.8, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 37/126 (29%), Gaps = 8/126 (6%) Query: 285 ENTPMIAGLGKAADLVSENCETYEAHMRD-------IRDYLEERLEAEFGKRIHLNSRFP 337 NTP GLG + + + D + +L++ + I + Sbjct: 111 PNTPGKIGLGVSGMYAEAEVSETDRRIADRIMKSVGLTVWLDDEEKMHGITGISGSGPAY 170 Query: 338 GVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHE-DRPSPVLLSCGIPVDV 396 L N +I+ T +V + + + ++ + S G Sbjct: 171 VFYLLDALQNAAIRQGFDMAEARALSLATFKGAVALAEQTGEDFEKLQKNVTSKGGTTHE 230 Query: 397 ARNAVR 402 A A R Sbjct: 231 AVEAFR 236 >3MEN-A nrPDB Length = 362 Score = 27.9 bits (60), Expect = 9.4, Method: Composition-based stats. Identities = 23/88 (26%), Positives = 34/88 (38%), Gaps = 8/88 (9%) Query: 255 ALYVRGVGKLTPLYPMLFGGGQERNFRPGT---ENTPMIAGLGKAADLVSENCETYEAHM 311 LYV G T YP + G ER G N PM G +AA E + + Sbjct: 230 VLYVSIHGDPTNFYPAVAGFDDERGAGEGLGYNVNLPMPHGSSEAAFF-----ERVDDAL 284 Query: 312 RDIRDYLEERLEAEFGKRIHLNSRFPGV 339 R++R + + L G ++ + V Sbjct: 285 RELRRFAPDALVLSLGFDVYRDDPQSQV 312 >5C2Z-A nrPDB Length = 255 Score = 27.5 bits (59), Expect = 10.0, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 39/110 (35%), Gaps = 8/110 (7%) Query: 23 DYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASL------AKMIGG 76 D+ T P + E+ + + + + + + +V G+ I + ++ A++ Sbjct: 20 DFFKTRPSDSELFSKIQDTTRSPYSSVGTVFVKGKTIATGILIGKNTVITNKHIARLAEN 79 Query: 77 KPQDIIFTSGGT--ESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRP 124 P +IFT G T E + +V E+ +P Sbjct: 80 DPNKVIFTPGSTRDEGSLVVKKPFGEFIAEEINEAPYGGGTDLSIIKLKP 129 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.116 0.278 Lambda K H 0.267 0.0356 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,468,409 Number of Sequences: 36641 Number of extensions: 492411 Number of successful extensions: 2229 Number of sequences better than 10.0: 93 Number of HSP's better than 10.0 without gapping: 65 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 1971 Number of HSP's gapped (non-prelim): 138 length of query: 432 length of database: 10,336,785 effective HSP length: 100 effective length of query: 332 effective length of database: 6,672,685 effective search space: 2215331420 effective search space used: 2215331420 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.9 bits)