BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q60972 (425 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5Y1U-A nrPDB 879 0.0 3C9C-A nrPDB 800 0.0 3CFV-B nrPDB 784 0.0 5WJC-A nrPDB 423 e-119 4XYI-A nrPDB 379 e-105 4PSX-B nrPDB 272 2e-73 6MZM-G nrPDB 85 5e-17 6F3T-A nrPDB 84 1e-16 6HQA-B nrPDB 74 9e-14 5NNZ-B nrPDB 72 3e-13 6QX9-5O nrPDB 72 5e-13 5Y88-O nrPDB 69 3e-12 4A11-B nrPDB 68 7e-12 5G04-R nrPDB 68 9e-12 4GGA-A nrPDB 67 1e-11 5LCW-Q nrPDB 67 1e-11 4V6W-Ag nrPDB 67 1e-11 2AQ5-A nrPDB 65 4e-11 3FM0-A nrPDB 65 7e-11 4N14-A nrPDB 65 8e-11 3DM0-A nrPDB 64 1e-10 5MZH-A nrPDB 64 1e-10 4BTS-AR nrPDB 63 2e-10 3W15-A nrPDB 60 1e-09 6N9G-C nrPDB 60 2e-09 4V8M-A7 nrPDB 60 2e-09 5FL8-q nrPDB 59 3e-09 5M25-A nrPDB 59 4e-09 6G51-g nrPDB 59 4e-09 5NZU-C nrPDB 59 6e-09 5OQL-d nrPDB 57 1e-08 2H9P-A nrPDB 57 1e-08 4V7E-Bg nrPDB 57 1e-08 6QX9-4B nrPDB 57 2e-08 6HHQ-h nrPDB 55 4e-08 5GAN-H nrPDB 55 5e-08 5XYI-g nrPDB 54 1e-07 1VYH-C nrPDB 54 2e-07 5OQL-L nrPDB 54 2e-07 6ID0-T nrPDB 53 2e-07 3JB9-L nrPDB 53 3e-07 5WLC-LU nrPDB 52 5e-07 5OPT-p nrPDB 52 5e-07 5A9Q-0 nrPDB 52 6e-07 4AEZ-A nrPDB 51 7e-07 5FA5-B nrPDB 51 9e-07 5WYJ-BC nrPDB 50 2e-06 5OQL-J nrPDB 50 2e-06 5L9T-R nrPDB 49 3e-06 3BG0-A nrPDB 49 5e-06 2PM9-A nrPDB 49 5e-06 6ELZ-p nrPDB 49 5e-06 5Z56-q nrPDB 49 6e-06 4BH6-A nrPDB 49 6e-06 2YNP-A nrPDB 48 6e-06 5A31-R nrPDB 48 7e-06 3JRP-A nrPDB 48 7e-06 4BZK-B nrPDB 48 7e-06 4LG8-A nrPDB 48 9e-06 3JB9-g nrPDB 48 9e-06 3MKQ-A nrPDB 48 1e-05 1NR0-A nrPDB 47 2e-05 3JRO-A nrPDB 46 2e-05 2HES-X nrPDB 45 5e-05 4L9O-A nrPDB 45 5e-05 6F1U-h nrPDB 45 6e-05 3EI3-B nrPDB 45 8e-05 6J6H-n nrPDB 43 2e-04 4G56-B nrPDB 43 2e-04 5UZ7-B nrPDB 43 2e-04 5CXC-A nrPDB 43 3e-04 4YCZ-A nrPDB 42 6e-04 4E5Z-B nrPDB 41 9e-04 6E29-D nrPDB 41 0.001 3JAP-g nrPDB 41 0.001 5WLC-LJ nrPDB 41 0.001 6BX3-B nrPDB 41 0.001 6EOJ-D nrPDB 40 0.001 5FVM-C nrPDB 40 0.001 6EMK-B nrPDB 40 0.001 6QDV-o nrPDB 40 0.002 5WLC-LO nrPDB 40 0.002 5YZG-W nrPDB 40 0.002 5K1B-B nrPDB 40 0.002 5I2T-A nrPDB 40 0.002 6Q8F-A nrPDB 39 0.005 6CB1-s nrPDB 37 0.018 5LTD-A nrPDB 37 0.019 6GMH-W nrPDB 37 0.019 6C0F-s nrPDB 37 0.021 5BJS-A nrPDB 37 0.023 6EM1-m nrPDB 37 0.024 4XFV-A nrPDB 36 0.028 3JZG-A nrPDB 36 0.030 1PI6-A nrPDB 36 0.037 5WLC-LW nrPDB 35 0.063 4OWR-A nrPDB 33 0.16 5MWJ-A nrPDB 33 0.16 5A9Q-2 nrPDB 33 0.17 5N4A-A nrPDB 33 0.18 5TF2-A nrPDB 33 0.21 5A9Q-7 nrPDB 33 0.24 4U1E-I nrPDB 33 0.29 5WBU-D nrPDB 33 0.30 4MDV-A nrPDB 32 0.44 5CXB-B nrPDB 32 0.60 4J0W-A nrPDB 31 1.0 5WYK-BB nrPDB 31 1.2 3F3P-A nrPDB 30 1.5 5WYJ-BE nrPDB 30 1.6 4MLJ-A nrPDB 30 1.8 5M89-A nrPDB 30 2.0 1VSU-A nrPDB 30 2.4 3I2N-A nrPDB 30 2.9 4J0X-A nrPDB 29 3.5 4CXU-A nrPDB 29 3.5 5AJA-A nrPDB 29 3.6 3ODT-A nrPDB 29 4.2 5VM9-A nrPDB 29 4.3 5ZKS-A nrPDB 29 4.4 3J3V-O nrPDB 28 6.6 5WLC-SG nrPDB 28 6.9 6CHG-A nrPDB 28 9.7 >5Y1U-A nrPDB Length = 456 Score = 879 bits (2270), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/425 (100%), Positives = 425/425 (100%) Query: 1 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD Sbjct: 32 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 91 Query: 61 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK Sbjct: 92 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 151 Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG Sbjct: 152 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 211 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE Sbjct: 212 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 271 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE Sbjct: 332 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 391 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP Sbjct: 392 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 451 Query: 421 EGQGS 425 EGQGS Sbjct: 452 EGQGS 456 >3C9C-A nrPDB Length = 432 Score = 800 bits (2066), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/409 (91%), Positives = 400/409 (97%) Query: 7 AFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRL 66 +FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVT+ +GKD+S+HRL Sbjct: 13 SFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRL 72 Query: 67 VLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126 +LGTHTSDEQNHL+IASVQLP++DAQFD SHYD+EKGEFGGFGSV GKIEIEIKINHEGE Sbjct: 73 ILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 132 Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 186 VNRARYMPQN C+IATKTPSSDVLVFDYTKHPSKP+PSGEC PDLRLRGHQKEGYGLSWN Sbjct: 133 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 192 Query: 187 PNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSV 246 PNL+G+LLSASDDHTICLWDI+A PKE +V+DAK IFTGHTAVVEDV+WHLLHESLFGSV Sbjct: 193 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 252 Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 ADDQKLMIWDTR+NNTSKPSH+VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL Sbjct: 253 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 312 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDGPPEL Sbjct: 313 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 372 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 LFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQVWQMAEN+YNDE+PE Sbjct: 373 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 421 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 22/165 (13%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL---RGHQKE 179 H EVN + P + I+AT + V ++D N L+L H+ E Sbjct: 278 HTAEVNCLSFNPYSEFILATGSADKTVALWDLR------------NLKLKLHSFESHKDE 325 Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT-------IFTGHTAVVED 232 + + W+P+ L S+ D + +WD+S + +E DA+ I GHTA + D Sbjct: 326 IFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISD 385 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 277 SW+ + SV++D + +W N + + A E N Sbjct: 386 FSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETN 430 >3CFV-B nrPDB Length = 414 Score = 784 bits (2024), Expect = 0.0, Method: Compositional matrix adjust. Identities = 375/412 (91%), Positives = 394/412 (95%), Gaps = 1/412 (0%) Query: 1 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60 MA KE F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD Sbjct: 4 MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 62 Query: 61 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120 +++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIK Sbjct: 63 YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK 122 Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 INHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEG Sbjct: 123 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 YGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHE Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 SLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVAL Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WDLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAE Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 >5WJC-A nrPDB Length = 430 Score = 423 bits (1087), Expect = e-119, Method: Compositional matrix adjust. Identities = 212/406 (52%), Positives = 277/406 (68%), Gaps = 21/406 (5%) Query: 14 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS 73 ++ I EEYK+WK+N PFLYDLV+THALEWPSLT QWLPD G D+SI RL+LGTHTS Sbjct: 23 QKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTS 82 Query: 74 -DEQNHLVIASVQLPNDDAQFDASHYDSEKGEFG------GFGSVSGKIEIEIKINHEGE 126 ++QN+L IASVQLPN +D + EF + S IEI KI H+G+ Sbjct: 83 GNDQNYLQIASVQLPN---------FDEDTTEFTPSTIRRAQATGSYTIEISQKIPHDGD 133 Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 186 VNRARYMPQ P IIAT + +FD T H + +GE P L+GH EG+GL WN Sbjct: 134 VNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALT--TGEALPQAVLKGHTAEGFGLCWN 191 Query: 187 PNLSGHLLSASDDHTICLWDI---SAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF 243 PNL G+L + ++D ICLWD+ S E KV+ + HT +V DV +H HE+L Sbjct: 192 PNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALL 251 Query: 244 GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 SV+DD L I DTR N + + AH+ +N ++ NP+++++LAT SADKTVALWDL Sbjct: 252 ASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDL 311 Query: 304 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP 363 RN +LH+ E H+DE++ ++WSPH+E ILASS TDRR+ +WDL KIGEEQ+PEDAEDG Sbjct: 312 RNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGS 371 Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 PELLF+HGGHT +IS+FSW PNE WV+ S+++DNI+Q+W + I+ Sbjct: 372 PELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIW 417 >4XYI-A nrPDB Length = 430 Score = 379 bits (973), Expect = e-105, Method: Compositional matrix adjust. Identities = 195/408 (47%), Positives = 274/408 (67%), Gaps = 25/408 (6%) Query: 14 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS 73 E+ I EEYK+WK+N PFLYDLV+T ALEWPSLT +W P R + SI +L+LGT TS Sbjct: 23 EKKIQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSLADNSSIQKLLLGTQTS 82 Query: 74 -DEQNHLVIASVQLPN--------DDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHE 124 ++QN+L +ASVQLP ++ +++ KG++G ++I KI+HE Sbjct: 83 GNDQNYLQVASVQLPTFDDDLDDLTPSKMKPANF---KGDYG--------LDIVQKIHHE 131 Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 G+VN+AR+MPQNP IIAT + + +FD + + P + LR H EG+GL Sbjct: 132 GDVNKARFMPQNPDIIATLGLNGNGYIFDLNLY--REQPIVQTGHQACLRHHTSEGFGLG 189 Query: 185 WNPNLSGHLLSASDDHTICLWDIS--AVPKEGKV-VDAKTIFTGHTAVVEDVSWHLLHES 241 WN G L + ++D +IC+WDI ++ E + V +++ HTAVV D+ +HL HE+ Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L SV+DD L I DTR ++S S V AH VN ++FNP+++++LAT SAD TVALW Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 DLR L +LH+ E H+DE++ VQWSPH+E IL +S TDRR+ VWDLSKIGEEQ+ ED+ED Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 G PEL+F+HGGHT ++SD SWNPN WV+ S+++DNI+Q+W ++ I+ Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIW 417 >4PSX-B nrPDB Length = 401 Score = 272 bits (696), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 150/399 (37%), Positives = 224/399 (56%), Gaps = 29/399 (7%) Query: 17 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS-DE 75 ++EEY +WK N P +YD V L WPSLT QWLP + F L++GTHTS +E Sbjct: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 Query: 76 QNHLVIASVQLP-----NDDAQFDASH-YDSEKGEFGGFGSVSGKIEIEIKINHEGEVNR 129 +N+L A + LP N+D Q +A Y S + I I K HE E+ R Sbjct: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQS------SLPAPRSNIRITAKYEHEEEITR 123 Query: 130 ARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNL 189 ARYMPQ+P I+AT ++ ++ L+ H+ GY LS++ + Sbjct: 124 ARYMPQDPNIVATINGQGTTFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLV 172 Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 G LLS SDDHT+ LW++ + K V +T H+ ++ D WH ++ LFG+V++D Sbjct: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 L I D R+NNT+ + N L+F+ +S +LA D V L+DLRN+K Sbjct: 231 SLLKINDVRANNTTIDTVKC---PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 LH H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+P+DAEDG PEL+ + Sbjct: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 H GH + ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 >6MZM-G nrPDB Length = 800 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 36/233 (15%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH YG S++P+ +LLS+S+D T+ LW + + + GH V D Sbjct: 539 LYGHSGPVYGASFSPD-RNYLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 590 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + F S D+ +W T + +P H A+VNC F+P S ++ ATG Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 645 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS---K 349 SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+ Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 +GE + GHT + ++ + ++ S S DN +++W Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 738 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 13/128 (10%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + ++PN S ++ + S D T+ LWD+ G V IFTGH + ++ Sbjct: 625 GHLADVNCTRFHPN-SNYVATGSADRTVRLWDV----LNGNCV---RIFTGHKGPIHSLT 676 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + + A D ++++WD + HT V L F+ E ILA+GS Sbjct: 677 FSP-NGRFLATGATDGRVLLWDIGHGLMVG---ELKGHTDTVCSLRFSRDGE-ILASGSM 731 Query: 295 DKTVALWD 302 D TV LWD Sbjct: 732 DNTVRLWD 739 >6F3T-A nrPDB Length = 608 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 36/233 (15%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH YG S++P+ +LLS+S+D T+ LW + + + GH V D Sbjct: 347 LYGHSGPVYGASFSPD-RNYLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 398 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + F S D+ +W T + +P H A+VNC F+P S ++ ATG Sbjct: 399 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 453 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS---K 349 SAD+TV LWD+ N + F HK I + +SP N LA+ TD R+ +WD+ Sbjct: 454 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 511 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 +GE + GHT + ++ + ++ S S DN +++W Sbjct: 512 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 546 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 13/128 (10%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + ++PN S ++ + S D T+ LWD+ G V IFTGH + ++ Sbjct: 433 GHLADVNCTRFHPN-SNYVATGSADRTVRLWDV----LNGNCV---RIFTGHKGPIHSLT 484 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + + A D ++++WD + HT V L F+ E ILA+GS Sbjct: 485 FSP-NGRFLATGATDGRVLLWDIGHGLMVG---ELKGHTDTVCSLRFSRDGE-ILASGSM 539 Query: 295 DKTVALWD 302 D TV LWD Sbjct: 540 DNTVRLWD 547 >6HQA-B nrPDB Length = 722 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 121/273 (44%), Gaps = 37/273 (13%) Query: 160 KPDPSGECNPD-------LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 212 K DP + N D RL GH YG+ ++P+ + +L+S S+D T+ LW + Sbjct: 429 KNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLD---- 483 Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAH 272 + GH++ V DV + + F + + DQ +W S + P H Sbjct: 484 ---TYTCLVSYKGHSSSVWDVKFSPMGH-YFATASHDQTARLW---SCDHIYPLRIFAGH 536 Query: 273 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 332 +V+C+ F+P S ++ TGS+DKT +WD+ + + F H I + SP Sbjct: 537 LNDVDCVEFHPNSTYLF-TGSSDKTARMWDIARGEC-VRVFMGHSGAINCLAVSPDGR-W 593 Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 LAS+G D + +WD+S ++ + G + I +++ E V+ S Sbjct: 594 LASAGEDSVVCLWDISTGRRIKA-------------MRGHGRSSIYSLAFS-REGTVLVS 639 Query: 393 VSEDNIMQVWQMAENIYN-DEDPEGSVDPEGQG 424 DN ++VW + +N + PE D QG Sbjct: 640 TGADNSVRVWDVKKNTNSPSAQPEPINDVTAQG 672 >5NNZ-B nrPDB Length = 415 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 102/210 (48%), Gaps = 28/210 (13%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 ++ S D T LWD +A +E ++ GH VV ++++ + + + D+ Sbjct: 107 FITGSYDRTCKLWD-TASGEELNTLE------GHRNVVYAIAFNNPYGDKIATGSFDKTC 159 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 +W S T K H+ HTAE+ CLSFNP S + ATGS D T LWD++N + ++++ Sbjct: 160 KLW---SVETGKCYHTFRGHTAEIVCLSFNPQSTLV-ATGSMDTTAKLWDIQNGE-EVYT 214 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 H EI + ++ + I+ S D + VW DA+ G + I G Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVNILI--G 259 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 H A+IS S+N + ++ + S D ++W Sbjct: 260 HCAEISSASFNWDCSLIL-TGSMDKTCKLW 288 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 104/235 (44%), Gaps = 40/235 (17%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT--GHTAVV 230 RGH E LS+NP S + + S D T LWDI + + ++T GH+A + Sbjct: 173 FRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQ---------NGEEVYTLRGHSAEI 222 Query: 231 EDVSWHLLHESLF-GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 +S++ + + GS D +++WD +T + + + H AE++ SFN IL Sbjct: 223 ISLSFNTSGDRIITGSF--DHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL 277 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GTDRRLNVWDL 347 TGS DKT LWD N K + + H DEI + + I +S GT R + Sbjct: 278 -TGSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 I + + GH +IS S+NP ++ + S D ++W Sbjct: 336 KCIAKLE-----------------GHEGEISKISFNPQGNHLL-TGSSDKTARIW 372 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 85/212 (40%), Gaps = 51/212 (24%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 LRGH E LS+N + +++ S DHT+ +WD G+ V+ I GH A + Sbjct: 215 LRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWD----ADTGRKVN---ILIGHCAEISS 266 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTR---------------------------------- 258 S++ SL + + D+ +WD Sbjct: 267 ASFNW-DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325 Query: 259 -----SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313 S T K ++ H E++ +SFNP +L TGS+DKT +WD + + L Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVL 383 Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 E H DEIF ++ ++ S D +W Sbjct: 384 EGHTDEIFSCAFNYKGNIVITGS-KDNTCRIW 414 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/174 (27%), Positives = 82/174 (47%), Gaps = 14/174 (8%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH+ Y +++N + + S D T LW + + GK F GHTA + Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV----ETGKCYHT---FRGHTAEIVC 182 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +S++ +L + + D +WD ++ + +++ H+AE+ LSFN + I+ TG Sbjct: 183 LSFN-PQSTLVATGSMDTTAKLWDIQNG---EEVYTLRGHSAEIISLSFNTSGDRII-TG 237 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 S D TV +WD + K++ H EI ++ IL S D+ +WD Sbjct: 238 SFDHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWD 289 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 8/56 (14%) Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 227 +L GH+ E +S+NP HLL+ S D T +WD + G+ + + GHT Sbjct: 340 KLEGHEGEISKISFNPQ-GNHLLTGSSDKTARIWD----AQTGQCLQ---VLEGHT 387 >6QX9-5O nrPDB Length = 357 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 107/234 (45%), Gaps = 29/234 (12%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 P + L GH+ E Y ++PN S L SA D I LW++ D GH+ Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGS-TLASAGFDRLILLWNVYGD------CDNYATLKGHSG 110 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V ++ ++ LF S + D+ + +WD+ + K + HT+ VN + Sbjct: 111 AVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVK---RLKGHTSFVNSCYPARRGPQL 166 Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 348 + TGS D TV LWD+R K + +F+ + ++ V ++ ++ I+ S G D + VWDL Sbjct: 167 VCTGSDDGTVKLWDIRK-KAAIQTFQ-NTYQVLAVTFNDTSDQII-SGGIDNDIKVWDLR 223 Query: 349 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + +L + GH ++ S + +++ S + DN ++VW Sbjct: 224 Q--------------NKLTYTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVW 262 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 47/240 (19%) Query: 172 RLRGHQK---EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 RL+GH Y P L + + SDD T+ LWDI K+ + + + Sbjct: 146 RLKGHTSFVNSCYPARRGPQL---VCTGSDDGTVKLWDIR---KKAAIQTFQNTYQVLAV 199 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 D S ++ + D + +WD R N K ++++ H V LS + ++ Sbjct: 200 TFNDTSDQIISGGI------DNDIKVWDLRQN---KLTYTMRGHADSVTGLSLSSEGSYL 250 Query: 289 LATGSADKTVALWDLRNLKLK----------LHSFESHKDEIFQVQWSPHNETILASSGT 338 L+ + D TV +WD+R K +H+FE + + + WSP I A S Sbjct: 251 LSN-AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN---LLRCSWSPDGSKIAAGS-A 305 Query: 339 DRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 DR + VWD + +L+ GH I++ +++P+EP +I + S+ + Sbjct: 306 DRFVYVWDTTS--------------RRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/147 (21%), Positives = 66/147 (44%), Gaps = 16/147 (10%) Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317 R ++ P + H EV C F+P LA+ D+ + LW++ + + H Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGS-TLASAGFDRLILLWNVYGDCDNYATLKGHS 109 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 + ++ ++ + ++L S+ TD+ + VWD S+ GE GHT+ + Sbjct: 110 GAVMELHYNT-DGSMLFSASTDKTVAVWD-SETGERVKRLK-------------GHTSFV 154 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQM 404 + P ++C+ S+D +++W + Sbjct: 155 NSCYPARRGPQLVCTGSDDGTVKLWDI 181 >5Y88-O nrPDB Length = 451 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 48/155 (30%), Positives = 81/155 (52%), Gaps = 14/155 (9%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 ++ S+D T+ +WD++ GK+ KT GH V DV+ H LF SV++D+ + Sbjct: 155 FITGSNDTTMKVWDLAT----GKL---KTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTV 206 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 WD N + + H + V +S +P + I AT D + LWD+R ++ + + Sbjct: 207 KCWDLEKNQIIRDYY---GHLSGVRTVSIHPTLDLI-ATAGRDSVIKLWDMRT-RIPVIT 261 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 HK I QVQ +P + +++SS TD + +WD+ Sbjct: 262 LVGHKGPINQVQCTPVDPQVVSSS-TDATVRLWDV 295 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 17/145 (11%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 K S ++ H V C++ +P TGS D T+ +WDL KLK + H + V Sbjct: 130 KLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT-TLAGHVMTVRDV 188 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 S + + + S D+ + WDL K +++ + GH + + S + Sbjct: 189 AVSDRHPYLFSVS-EDKTVKCWDLEK--------------NQIIRDYYGHLSGVRTVSIH 233 Query: 384 PNEPWVICSVSEDNIMQVWQMAENI 408 P +I + D+++++W M I Sbjct: 234 PTLD-LIATAGRDSVIKLWDMRTRI 257 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 42/151 (27%), Positives = 68/151 (45%), Gaps = 20/151 (13%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +L S S+D T+ WD+ K + D + GH + V VS H + L + D Sbjct: 196 YLFSVSEDKTVKCWDLE---KNQIIRD----YYGHLSGVRTVSIHPTLD-LIATAGRDSV 247 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKL 308 + +WD R T P ++ H +N + P ++++ S D TV LWD+ + +K+ Sbjct: 248 IKLWDMR---TRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLWDVVAGKTMKV 303 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTD 339 H HK + P E +AS+ TD Sbjct: 304 LTH----HKRSVRATALHP-KEFSVASACTD 329 >4A11-B nrPDB Length = 408 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 94/223 (42%), Gaps = 20/223 (8%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG------HTAVVEDVSWHLLHESLFGS 245 ++LS D I L+D+ ++ G H VE V W+ +F S Sbjct: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS--FNPYS--EFILATGSADKTVALW 301 + D+ L +WDT + T+ D E S +P S ++A G+ V L Sbjct: 118 SSFDKTLKVWDTNTLQTA------DVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLC 171 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ + D + Sbjct: 172 DLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN 230 Query: 362 GPPELLF--IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 G + H K++ + + ++ +V DN M++W Sbjct: 231 GKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLW 272 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 81/180 (45%), Gaps = 23/180 (12%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W P+ +G S+S D T+ +WD + + +T+++ H + V L Sbjct: 105 VQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVST------KHCL 158 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 K+ + D +S + S H + H E+ +S++P ++ILAT SAD V LWD Sbjct: 159 VAVGTRGPKVQLCDLKSGSCS---HILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 303 LRNLKLKLHSFESH---KDEIFQVQWSPHNETI-----------LASSGTDRRLNVWDLS 348 +R L + + H K + + + HN + L + GTD R+ +W+ S Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 66/175 (37%), Gaps = 42/175 (24%) Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF------------ESHKDE 319 H +N L P + +G +D + L+DL N + + + H+ Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKI-------------GEEQSPEDAE------ 360 + VQW PH+ + SS D+ L VWD + + SP + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 361 --DGPPELLF---------IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 GP L I GH +I SW+P +++ + S D+ +++W + Sbjct: 162 GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 >5G04-R nrPDB Length = 499 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 87/202 (43%), Gaps = 11/202 (5%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH +E GL W P+ HL S +D+ + +W + P EG V +T FT H V+ Sbjct: 305 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 360 Query: 233 VSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 V+W ++ G D+ + IW+ S +VDAH+ + L Y E I Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 417 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 418 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 475 Query: 351 GEEQSPEDAEDGPPELLFIHGG 372 + E + + IH G Sbjct: 476 DPARRREREKASAAKSSLIHQG 497 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 77/157 (49%), Gaps = 15/157 (9%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA-D 248 SG++L+ + D+++ LW S+ G ++ + + V+W + E + +V Sbjct: 194 SGNVLAVALDNSVYLWSASS----GDILQLLQM-EQPGEYISSVAW--IKEGNYLAVGTS 246 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308 ++ +WD + K ++ +H+A V LS+N Y IL++GS + D+R + Sbjct: 247 SAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEH 300 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 + + H E+ ++W+P LAS G D +NVW Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW 336 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 71/174 (40%), Gaps = 38/174 (21%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLHSFESHKDEIFQVQ 324 ++ H+ EV L + P LA+G D V +W + + L +F H+ + V Sbjct: 304 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 Query: 325 WSPHNETILASSG--TDRRLNVWDLSKIGEEQSPEDAED-------GP--PELLFIHG-- 371 W P +LA+ G +DR + +W++ G S DA P EL+ HG Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 Query: 372 -------------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 GHT+++ + +P+ + S + D +++W+ E Sbjct: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 474 >4GGA-A nrPDB Length = 420 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 87/202 (43%), Gaps = 11/202 (5%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH +E GL W P+ HL S +D+ + +W + P EG V +T FT H V+ Sbjct: 226 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 281 Query: 233 VSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 V+W ++ G D+ + IW+ S +VDAH+ + L Y E I Sbjct: 282 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 338 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 339 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 396 Query: 351 GEEQSPEDAEDGPPELLFIHGG 372 + E + + IH G Sbjct: 397 DPARRREREKASAAKSSLIHQG 418 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 88/197 (44%), Gaps = 22/197 (11%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA-D 248 SG++L+ + D+++ LW S+ G ++ + + V+W + E + +V Sbjct: 115 SGNVLAVALDNSVYLWSASS----GDILQLLQM-EQPGEYISSVAW--IKEGNYLAVGTS 167 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308 ++ +WD + K ++ +H+A V LS+N Y IL++GS + D+R + Sbjct: 168 SAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEH 221 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 + + H E+ ++W+P LAS G D +NVW +P + P + Sbjct: 222 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWP-------SAPGEGGWVPLQTFT 273 Query: 369 IHGGHTAKISDFSWNPN 385 H G ++ W N Sbjct: 274 QHQGAVKAVAWCPWQSN 290 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 70/174 (40%), Gaps = 38/174 (21%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLHSFESHKDEIFQVQ 324 ++ H+ EV L + P LA+G D V +W + + L +F H+ + V Sbjct: 225 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 283 Query: 325 WSPHNETILASSG--TDRRLNVWDLSKIGEEQSPEDAEDGP---------PELLFIHG-- 371 W P +LA+ G +DR + +W++ G S DA EL+ HG Sbjct: 284 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 342 Query: 372 -------------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 GHT+++ + +P+ + S + D +++W+ E Sbjct: 343 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 395 >5LCW-Q nrPDB Length = 374 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 87/202 (43%), Gaps = 11/202 (5%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH +E GL W P+ HL S +D+ + +W + P EG V +T FT H V+ Sbjct: 180 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 235 Query: 233 VSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 V+W ++ G D+ + IW+ S +VDAH+ + L Y E I Sbjct: 236 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 292 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 G A + +W + K+ + H + + SP T+ AS+ D L +W ++ Sbjct: 293 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCFEL 350 Query: 351 GEEQSPEDAEDGPPELLFIHGG 372 + E + + IH G Sbjct: 351 DPARRREREKASAAKSSLIHQG 372 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 88/197 (44%), Gaps = 22/197 (11%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA-D 248 SG++L+ + D+++ LW S+ G ++ + + V+W + E + +V Sbjct: 69 SGNVLAVALDNSVYLWSASS----GDILQLLQM-EQPGEYISSVAW--IKEGNYLAVGTS 121 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308 ++ +WD + K ++ +H+A V LS+N Y IL++GS + D+R + Sbjct: 122 SAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEH 175 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 + + H E+ ++W+P LAS G D +NVW +P + P + Sbjct: 176 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW-------PSAPGEGGWVPLQTFT 227 Query: 369 IHGGHTAKISDFSWNPN 385 H G ++ W N Sbjct: 228 QHQGAVKAVAWCPWQSN 244 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 70/174 (40%), Gaps = 38/174 (21%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK---LKLHSFESHKDEIFQVQ 324 ++ H+ EV L + P LA+G D V +W + + L +F H+ + V Sbjct: 179 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 237 Query: 325 WSPHNETILASSG--TDRRLNVWDLSKIGEEQSPEDAEDGP---------PELLFIHG-- 371 W P +LA+ G +DR + +W++ G S DA EL+ HG Sbjct: 238 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 296 Query: 372 -------------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 GHT+++ + +P+ + S + D +++W+ E Sbjct: 297 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 349 >4V6W-Ag nrPDB Length = 318 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 131/288 (45%), Gaps = 39/288 (13%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK-- 178 I H G V + P++P I + + ++V+ T+ + + P RL GH Sbjct: 12 IGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTR----DEDTNYGYPQKRLYGHSHFI 67 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 LS + N + LS S D T+ LWD++A GK F GHT V V++ Sbjct: 68 SDVVLSSDGN---YALSGSWDQTLRLWDLAA----GKTTRR---FEGHTKDVLSVAFSAD 117 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP-YSEFILATGSADKT 297 + + S + D+ + +W+T + K + D HT V+C+ F+P +S I+ + D+T Sbjct: 118 NRQIV-SGSRDKTIKLWNTLAE--CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRT 174 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE 357 V +W+L N KLK ++ H + V SP + ++ S G D + +WDL+ + E Sbjct: 175 VKVWNLANCKLK-NNHHGHNGYLNTVTVSP-DGSLCTSGGKDSKALLWDLNDGKNLYTLE 232 Query: 358 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 H I+ ++PN W+ V+ +++W +A Sbjct: 233 ---------------HNDIINALCFSPNRYWLC--VAYGPSIKIWDLA 263 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/250 (26%), Positives = 114/250 (45%), Gaps = 26/250 (10%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH ++ NP ++SAS D T+ +W ++ K ++ GH+ + D Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY-GHSHFISD 69 Query: 233 VSWHLL----HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V +L + +L GS DQ L +WD + T++ + HT +V ++F+ + I Sbjct: 70 V---VLSSDGNYALSGSW--DQTLRLWDLAAGKTTR---RFEGHTKDVLSVAFSADNRQI 121 Query: 289 LATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSP-HNETILASSGTDRRLNVWD 346 ++ GS DKT+ LW+ L K + + H D + V++SP H+ I+ S G DR + VW+ Sbjct: 122 VS-GSRDKTIKLWNTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 347 LSKI-------GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 399 L+ G P L GG +K W+ N+ + ++ ++I+ Sbjct: 180 LANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKA--LLWDLNDGKNLYTLEHNDII 237 Query: 400 QVWQMAENIY 409 + N Y Sbjct: 238 NALCFSPNRY 247 Score = 28.1 bits (61), Expect = 8.2, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDED 413 GH ++ + NP +P I S S D + VW++ DED Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTR----DED 50 >2AQ5-A nrPDB Length = 402 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/221 (21%), Positives = 100/221 (45%), Gaps = 13/221 (5%) Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 +P + +C D+R+ + + NP + AS + + K G+V Sbjct: 17 QPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLG---KTGRVDKN 73 Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN----TSKPSHSVDAHTAE 275 + GHTA V D++W ++++ S ++D +M+W+ +P +++ HT Sbjct: 74 VPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKR 133 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSPHNETILA 334 V ++++P ++ +L + D + +WD+ L + H D I+ V WS + ++ Sbjct: 134 VGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS-RDGALIC 192 Query: 335 SSGTDRRLNVWDLSK---IGEEQSPEDAEDGPPELLFIHGG 372 +S D+R+ V + K + E+ P + P +F+ G Sbjct: 193 TSCRDKRVRVIEPRKGTVVAEKDRPHEGTR-PVHAVFVSEG 232 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 46/115 (40%), Gaps = 19/115 (16%) Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 TG DK V L H + + W PHN+ ++AS D + VW++ Sbjct: 67 TGRVDKNVPL------------VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDG 114 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 G E + GHT ++ +W+P V+ S DN++ VW + Sbjct: 115 GLVLPLR-------EPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVG 162 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 91/216 (42%), Gaps = 46/216 (21%) Query: 112 SGKIE--IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPD-----PS 164 +G+++ + + H V + P N +IA+ + V+V++ PD P Sbjct: 67 TGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI------PDGGLVLPL 120 Query: 165 GECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI---SAVPKEGKVVDAKT 221 E P + L GH K ++W+P LLSA D+ I +WD+ +AV G V T Sbjct: 121 RE--PVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDT 178 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNT----------SKPSHSVDA 271 I++ V W +L + D+++ + + R ++P H+V Sbjct: 179 IYS--------VDWS-RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFV 229 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 ++ F+ SE + VALWD ++L+ Sbjct: 230 SEGKILTTGFSRMSE---------RQVALWDTKHLE 256 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 22/36 (61%) Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 GHTA + D +W P+ VI S SED + VW++ + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDG 114 >3FM0-A nrPDB Length = 345 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 12/211 (5%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GHQ+ ++W+P +L SAS D T C+W K + T GH V+ V+ Sbjct: 59 GHQRTVRKVAWSP-CGNYLASASFDATTCIWK-----KNQDDFECVTTLEGHENEVKSVA 112 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 W +L + + D+ + +W+ + + +++HT +V + ++P E +LA+ S Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASY 170 Query: 295 DKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 D TV L+ + + + + E H+ ++ + + P + LAS DR + +W G E Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229 Query: 354 QSPEDAEDGP--PELLFIHGGHTAKISDFSW 382 Q + P + + G H+ I D +W Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 15/143 (10%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW------DISAVPKEGKVVDAKTIFT-- 224 L GH+ + L+++P+ L S SDD T+ +W + V G K I T Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 225 -GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV-----DAHTAEVNC 278 H+ + D++W L +L + DD + + +++ +P+ S+ AH+ +VNC Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 279 LSFNPYSEFILATGSADKTVALW 301 +++NP +LA+ S D VA W Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 82/204 (40%), Gaps = 46/204 (22%) Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 +L S D+++ IW T ++ S + H V ++++P + LA+ S D T + Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87 Query: 301 WDLRNLKLK-LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 W + + + E H++E+ V W+P +LA+ D+ + VW++ D Sbjct: 88 WKKNQDDFECVTTLEGHENEVKSVAWAPSG-NLLATCSRDKSVWVWEV----------DE 136 Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WVICSVSEDNIM 399 ED E + + HT + W+P++ WV C+ E + Sbjct: 137 ED-EYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195 Query: 400 QVWQMAENIYNDEDPEGSVDPEGQ 423 VW +A DP GQ Sbjct: 196 TVWSLA------------FDPSGQ 207 Score = 27.7 bits (60), Expect = 9.3, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 303 LRNLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRRLNVW 345 +++ + L +H D + + W+P T+LAS G DRR+ +W Sbjct: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPAG-TLLASCGGDRRIRIW 43 >4N14-A nrPDB Length = 314 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 11/175 (6%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH +E GL W P+ HL S +D+ + +W + P EG V +T FT H V+ Sbjct: 142 LSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWP--SAPGEGGWVPLQT-FTQHQGAVKA 197 Query: 233 VSWHLLHESLF--GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 V+W ++ G D+ + IW+ S +VDAH+ + L Y E I Sbjct: 198 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLS---AVDAHSQVCSILWSPHYKELISG 254 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 G A + +W + K+ + H + + SP T+ AS+ D L +W Sbjct: 255 HGFAQNQLVIWKYPTMA-KVAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLW 307 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 88/197 (44%), Gaps = 22/197 (11%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA-D 248 SG++L+ + D+++ LW S+ G ++ + + V+W + E + +V Sbjct: 31 SGNVLAVALDNSVYLWSASS----GDILQLLQM-EQPGEYISSVAW--IKEGNYLAVGTS 83 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308 ++ +WD + K ++ +H+A V LS+N Y IL++GS + D+R + Sbjct: 84 SAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEH 137 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 + + H E+ ++W+P LAS G D +NVW +P + P + Sbjct: 138 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW-------PSAPGEGGWVPLQTFT 189 Query: 369 IHGGHTAKISDFSWNPN 385 H G ++ W N Sbjct: 190 QHQGAVKAVAWCPWQSN 206 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 69/174 (39%), Gaps = 38/174 (21%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEIFQVQ 324 ++ H+ EV L + P LA+G D V +W + L +F H+ + V Sbjct: 141 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 199 Query: 325 WSPHNETILASSG--TDRRLNVWDLSKIGEEQSPEDAEDGP---------PELLFIHG-- 371 W P +LA+ G +DR + +W++ G S DA EL+ HG Sbjct: 200 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 258 Query: 372 -------------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 GHT+++ + +P+ + S + D +++W+ E Sbjct: 259 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFE 311 >3DM0-A nrPDB Length = 694 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 120/272 (44%), Gaps = 38/272 (13%) Query: 136 NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK--EGYGLSWNPNLSGHL 193 N II + + ++++ TK D RL GH E LS + + Sbjct: 394 NADIIVSASRDKSIILWKLTK-----DDKAYGVAQRRLTGHSHFVEDVVLSSDGQFA--- 445 Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253 LS S D + LWD++A + F GHT V V++ L + + S + D+ + Sbjct: 446 LSGSWDGELRLWDLAAGVSTRR-------FVGHTKDVLSVAFSLDNRQIV-SASRDRTIK 497 Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLRNLKLKLHS 312 +W+T S + H V+C+ F+P + + + + S DKTV +W+L N KL+ + Sbjct: 498 LWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLR-ST 556 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 H + V SP + ++ AS G D + +WDL++ + S E Sbjct: 557 LAGHTGYVSTVAVSP-DGSLCASGGKDGVVLLWDLAEGKKLYSLE--------------- 600 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 + I ++PN W +C+ +E I ++W + Sbjct: 601 ANSVIHALCFSPNRYW-LCAATEHGI-KIWDL 630 >5MZH-A nrPDB Length = 452 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 101/231 (43%), Gaps = 32/231 (13%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L+GHQ E LS+NP S + + S D+T LWD+ + + GH A + Sbjct: 175 LKGHQTEIVCLSFNPQ-STIIATGSMDNTAKLWDVETGQE-------RATLAGHRAEIVS 226 Query: 233 VSWHLLHESLF-GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 + ++ + + GS D +L WD R T + H + H EV+ FN Y+ ++ + Sbjct: 227 LGFNTGGDLIVTGSFDHDSRL--WDVR---TGQCVHVLSGHRGEVSSTQFN-YAGTLVVS 280 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 GS D T LWD+R+ + L + H DE+ V + ++++S L+ + Sbjct: 281 GSIDCTSRLWDVRSGRC-LSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVC 339 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + GH +IS ++NP +I + S D ++W Sbjct: 340 QHTLV---------------GHEGEISKVAFNPQGTRLI-TASSDKTCRLW 374 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 50/174 (28%), Positives = 78/174 (44%), Gaps = 17/174 (9%) Query: 173 LRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 L GH+ E +N +G L+ S S D T LWD+ + G+ + K GHT V Sbjct: 259 LSGHRGEVSSTQFN--YAGTLVVSGSIDCTSRLWDV----RSGRCLSVKQ---GHTDEVL 309 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 DV++ + + AD + T H++ H E++ ++FNP ++ T Sbjct: 310 DVAFDAAGTKMVSASADGSARLY----HTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-T 364 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 S+DKT LWD + L E H DEIF ++ + I+ S D +W Sbjct: 365 ASSDKTCRLWDCDTGEC-LQVLEGHTDEIFSCAFNYEGDFIITGS-KDNTCRIW 416 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/143 (26%), Positives = 70/143 (48%), Gaps = 21/143 (14%) Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PYSEFILATGSADKTVALWDLRNLK 307 D+ +W+T T + +++ H V ++FN PY + I+ TGS DKT LWD + Sbjct: 115 DRTCKVWNT---FTGEEVFTLEGHKNVVYAIAFNNPYGDKIV-TGSFDKTCKLWDAYTGQ 170 Query: 308 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELL 367 L ++ + H+ EI + ++P + TI+A+ D +WD+ + G+E++ Sbjct: 171 L-YYTLKGHQTEIVCLSFNPQS-TIIATGSMDNTAKLWDV-ETGQERATL---------- 217 Query: 368 FIHGGHTAKISDFSWNPNEPWVI 390 GH A+I +N ++ Sbjct: 218 ---AGHRAEIVSLGFNTGGDLIV 237 >4BTS-AR nrPDB Length = 343 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 101/228 (44%), Gaps = 33/228 (14%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG-SVADDQK 251 L+S S D T+ +W + + G TGH V D++ L E+ F S + D+ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLA--LSQENCFAISSSWDKT 99 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKL 310 L +WD R+ T K H +EV ++F+P + IL+ G A++ + LW+ L K Sbjct: 100 LRLWDLRTGTTYK---RFVGHQSEVYSVAFSPDNRQILSAG-AEREIKLWNILGECKFSS 155 Query: 311 HSFESHKDEIFQVQWSPHNET---------ILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 E+H D + V++SP ++ AS G D RL VW+ + Sbjct: 156 AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTN------------- 202 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 ++ + H + ++ S +PN + I + +D + +W + Y Sbjct: 203 --FQIRYTFKAHESNVNHLSISPNGKY-IATGGKDKKLLIWDILNLTY 247 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/185 (28%), Positives = 93/185 (50%), Gaps = 23/185 (12%) Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 R GHQ E Y ++++P+ + +LSA + I LW+I E K A+ H+ V Sbjct: 113 RFVGHQSEVYSVAFSPD-NRQILSAGAEREIKLWNILG---ECKFSSAEK--ENHSDWVS 166 Query: 232 DVSWHLLHES---------LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 V + + +S F SV D +L +W+T + ++ AH + VN LS + Sbjct: 167 CVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT----NFQIRYTFKAHESNVNHLSIS 222 Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 P ++I ATG DK + +WD+ NL F++ I Q+ ++P + + + GTD+ + Sbjct: 223 PNGKYI-ATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQWV--AVGTDQGV 278 Query: 343 NVWDL 347 +++L Sbjct: 279 KIFNL 283 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 39/108 (36%), Gaps = 49/108 (45%) Query: 288 ILATGSADKTVALWDL-----------------------------------------RNL 306 +L +GS DKTV +W L + L Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTL 100 Query: 307 KL-------KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 +L F H+ E++ V +SP N IL S+G +R + +W++ Sbjct: 101 RLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNI 147 >3W15-A nrPDB Length = 368 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 33/267 (12%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD-------ISAVPKE---GKVVD 218 P + H++E + +WN + LS+S D +I +W ++ P+ K+VD Sbjct: 98 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 157 Query: 219 -------AKTIFTG---HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS 268 K FTG + V + ++L S + + ++D R + ++ Sbjct: 158 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 217 Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL---KLHSFE-------SHKD 318 + E FN Y +++ATG D + +WD+R L +LH+ +H Sbjct: 218 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 319 EIFQVQWSPHNETILASSGTDRRLNVW-DLSKIG-EEQSPEDAEDGPPELLFIHGGHTAK 376 I +V WSPH+ IL S+ D +W DLS G +E ++ D +F H+ Sbjct: 278 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 337 Query: 377 ISDFSWNP-NEPWVICSVSEDNIMQVW 402 + W+ +P + S + D + VW Sbjct: 338 VFGADWSLWGKPGYVASTAWDGNLFVW 364 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/253 (21%), Positives = 104/253 (41%), Gaps = 35/253 (13%) Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 + L+WN + +L A D T+ L+D + KE + IF H V +W+L++ Sbjct: 66 FDLAWNESHENQVLVAQGDGTLRLFDTTF--KEFPIA----IFKEHEREVFSCNWNLVNR 119 Query: 241 SLFGSVADDQKLMIWDTRSNN-----TSKP---SHSVDAHTAEV-------------NCL 279 F S + D + IW T +P + VD A + NC+ Sbjct: 120 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 280 ---SFNPYSEFILATGSADKTVALWDLRNLKLK-LHSFESHKD-EIFQVQWSPHNETILA 334 F+P+ + ++ + S + +L+D+R K ++F H E ++ + ++A Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 239 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + G D + +WD+ + + E I H I +W+P+ ++ S S Sbjct: 240 TGGVDNAIRIWDIRMLNKNPGQLHNSSCINE---IPNAHGLAIRKVTWSPHHSNILMSAS 296 Query: 395 EDNIMQVWQMAEN 407 D ++W+ N Sbjct: 297 YDMTCRIWRDLSN 309 >6N9G-C nrPDB Length = 353 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 102/216 (47%), Gaps = 35/216 (16%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES----LFGSVA 247 +L+AS D T LWD+ + G+++ + F GH A DV L S F S Sbjct: 167 QILTASGDGTCALWDV----ESGQLLQS---FHGHGA---DVLCLDLAPSETGNTFVSGG 216 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NL 306 D+K M+WD RS + + + H ++VN + + P + A+GS D T L+DLR + Sbjct: 217 CDKKAMVWDMRSGQCVQ---AFETHESDVNSVRYYPSGD-AFASGSDDATCRLYDLRADR 272 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 ++ ++S ES V +S + A D +NVWD+ K G S + Sbjct: 273 EVAIYSKESIIFGASSVDFSLSGRLLFAGY-NDYTINVWDVLK-GSRVS----------I 320 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 LF GH ++S +P+ CS S D+ ++VW Sbjct: 321 LF---GHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 >4V8M-A7 nrPDB Length = 318 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 90/352 (25%), Positives = 143/352 (40%), Gaps = 98/352 (27%) Query: 119 IKINHEGEVNRAR------YMPQNPCIIATKTPSSDVLVFDYTKHPSKPDP---SGECN- 168 + + +EG++ R PQ P ATK S+ D T P+P S EC+ Sbjct: 1 MAVAYEGQLTGHRGWVTSLACPQTP-ETATKVVSTS---RDKTLLSWGPNPDRHSSECSY 56 Query: 169 --PDLRLRGHQK--EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 224 PD RL GH LS N N + +SAS DH++ LW++ + G+ + F Sbjct: 57 GLPDRRLEGHSAFVSDVALSNNGNFA---VSASWDHSLRLWNL----QNGQ---CQYKFL 106 Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284 GHT V V++ + + S D L +W+ + S AHT V+C+ F+P Sbjct: 107 GHTKDVLSVAFSPDNRQIV-SGGRDNALRVWNVKGECMHTLSRG--AHTDWVSCVRFSPS 163 Query: 285 SEF-ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 + ++ +G D V +WDL +L + + H + + V SP + ++ ASS D Sbjct: 164 LDAPVIVSGGWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTVSP-DGSLCASSDKDGVAR 221 Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE-------- 395 +WDL+K GE S A G P I+ ++PN W +C+ +E Sbjct: 222 LWDLTK-GEALSEMAA--GAP------------INQICFSPNRYW-MCAATEKGIRIFDL 265 Query: 396 ----------------------------------------DNIMQVWQMAEN 407 DN+++VW ++EN Sbjct: 266 ENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 >5FL8-q nrPDB Length = 515 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 40/173 (23%), Positives = 79/173 (45%), Gaps = 27/173 (15%) Query: 247 ADDQKLMIWDTRSNNTSKP----SHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 +DQ +++ R+ KP S ++ H + + C +F P++ + TG+ D T +WD Sbjct: 113 TEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWD 172 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 + + +H+ + H + + V WSP E ++A+ D + +WD P+ + Sbjct: 173 C-DTQTPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRLWD---------PKSGQCL 221 Query: 363 PPELLFIHGGHTAKISDFSWNP-------NEPWVICSVSEDNIMQVWQMAENI 408 L GH+ I+ SW P ++P + S S+D +++W + Sbjct: 222 GDALR----GHSKWITSLSWEPIHLVKPGSKP-RLASSSKDGTIKIWDTVSRV 269 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 113/289 (39%), Gaps = 75/289 (25%) Query: 162 DP-SGECNPDLRLRGHQKEGYGLSW------NPNLSGHLLSASDDHTICLWD-ISAVPKE 213 DP SG+C D LRGH K LSW P L S+S D TI +WD +S V Sbjct: 214 DPKSGQCLGDA-LRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRV--- 269 Query: 214 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHT 273 + +GHT V V W + L S + D+ + +WD N+ + + + +H Sbjct: 270 -----CQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTVRVWDI--NSQGRCINILKSHA 320 Query: 274 AEVNCLSF--------------------------------------NPYSEFILATGSAD 295 VN LS N SE ++ T S D Sbjct: 321 HWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDD 380 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 T+ LW+ + H+ + V +SP I+++S D + +W Sbjct: 381 YTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSAS-FDNSIKLW---------- 429 Query: 356 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 D DG + + GH A + +W+ ++ ++ S S+D ++VW + Sbjct: 430 --DGRDG--KFISTFRGHVASVYQVAWS-SDCRLLVSCSKDTTLKVWDV 473 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 78/160 (48%), Gaps = 13/160 (8%) Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 N N +++ASDD+T+ LW+ P + A+ TGH +V V++ + S Sbjct: 367 NGNSEEMMVTASDDYTMFLWN----PLKSTKPIAR--MTGHQKLVNHVAFSPDGRYIV-S 419 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 + D + +WD R K + H A V ++++ +L + S D T+ +WD+R Sbjct: 420 ASFDNSIKLWDGRDG---KFISTFRGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWDVRT 475 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 KL + HKDE++ V WS + + S G D+ + +W Sbjct: 476 RKLSV-DLPGHKDEVYTVDWSVDGKRV-CSGGKDKMVRLW 513 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 83/189 (43%), Gaps = 25/189 (13%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT---IFTGHTAV 229 + GH ++ P+ S +++ + D+T +WD D +T GH Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWD----------CDTQTPMHTLKGHYNW 188 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY----- 284 V VSW E + + + D + +WD +S ++ H+ + LS+ P Sbjct: 189 VLCVSWSPDGE-VIATGSMDNTIRLWDPKSGQCL--GDALRGHSKWITSLSWEPIHLVKP 245 Query: 285 -SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 S+ LA+ S D T+ +WD + ++ ++ H + + V+W + +L S DR + Sbjct: 246 GSKPRLASSSKDGTIKIWDTVS-RVCQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTVR 302 Query: 344 VWDLSKIGE 352 VWD++ G Sbjct: 303 VWDINSQGR 311 >5M25-A nrPDB Length = 434 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 114/236 (48%), Gaps = 34/236 (14%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 + GH+ ++W+ + S L+SASDD T+ +WD+S+ GK + GH+ V Sbjct: 183 ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSS----GKCLKT---LKGHSNYVFC 234 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +++ +L S + D+ + IWD + T K ++ AH+ V+ + FN I+++ Sbjct: 235 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 289 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D +WD + + + + V++SP+ + ILA++ D L +WD SK Sbjct: 290 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK--- 345 Query: 353 EQSPEDAEDGPPELLFIHGGHTAK----ISDFSWNPNEPWVICSVSEDNIMQVWQM 404 + L + GH + ++FS + W++ S SEDN++ +W + Sbjct: 346 -----------GKCLKTYTGHKNEKYCIFANFSVTGGK-WIV-SGSEDNLVYIWNL 388 >6G51-g nrPDB Length = 317 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 114/269 (42%), Gaps = 39/269 (14%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L+GH ++ P +LSAS D TI +W ++ E + GH+ V D Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR--DETNYGIPQRALRGHSHFVSD 68 Query: 233 VSWHLLHESLFG-SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 V + + F S + D L +WD + T++ HT +V ++F+ + I++ Sbjct: 69 VV--ISSDGQFALSGSWDGTLRLWDLTTGTTTR---RFVGHTKDVLSVAFSSDNRQIVS- 122 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLNVWDLSK- 349 GS DKT+ LW+ + ESH + + V++SP++ I+ S G D+ + VW+L+ Sbjct: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 Query: 350 ------IGEEQSPEDAEDGPPELLFIHGGHTAK--------------------ISDFSWN 383 IG P L GG + I+ ++ Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFS 242 Query: 384 PNEPWVICSVSEDNIMQVWQMAENIYNDE 412 PN W +C+ + +I ++W + I DE Sbjct: 243 PNRYW-LCAATGPSI-KIWDLEGKIIVDE 269 >5NZU-C nrPDB Length = 905 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 73/156 (46%), Gaps = 17/156 (10%) Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 ADD ++ +++ NT + H +AH+ + C++ +P FIL T S D + LWD Sbjct: 76 ADDMQIRVFNY---NTLERVHMFEAHSDYIRCIAVHPTQPFIL-TSSDDMLIKLWDWDKK 131 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 FE H + Q+ +P + AS+ DR + VW L + E E G + Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + GG ++P++I S ++D ++++W Sbjct: 192 DYYSGG------------DKPYLI-SGADDRLVKIW 214 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 71/158 (44%), Gaps = 20/158 (12%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 +L++SDD I LWD K +F GHT V + + + F S + D+ + Sbjct: 114 ILTSSDDMLIKLWDWD------KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTI 167 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSF-----NPYSEFILATGSADKTVALWDLRNLK 307 +W S S P+ +++ H VNC+ + PY L +G+ D+ V +WD +N K Sbjct: 168 KVWQLGS---SSPNFTLEGHEKGVNCIDYYSGGDKPY----LISGADDRLVKIWDYQN-K 219 Query: 308 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 + + E H + + P I+ S D + +W Sbjct: 220 TCVQTLEGHAQNVSCASFHPELPIIITGS-EDGTVRIW 256 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 14/139 (10%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI-SAVPKEGKVVDAKTIFTGHTAVVE 231 GH + NP + SAS D TI +W + S+ P GH V Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPN--------FTLEGHEKGVN 189 Query: 232 DVSWHLLHES-LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 + ++ + S ADD+ + IWD ++ + +++ H V+C SF+P I+ Sbjct: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ---TLEGHAQNVSCASFHPELPIII- 245 Query: 291 TGSADKTVALWDLRNLKLK 309 TGS D TV +W +L+ Sbjct: 246 TGSEDGTVRIWHSSTYRLE 264 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 42/189 (22%), Positives = 73/189 (38%), Gaps = 20/189 (10%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 +D K T + V+ V H + S+ + + +W+ + K D V Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGS-VCVWNHETQTLVKTFEVCDL---PV 60 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 F +++ TG+ D + +++ L+ ++H FE+H D I + P IL SS Sbjct: 61 RAAKFVARKNWVV-TGADDMQIRVFNYNTLE-RVHMFEAHSDYIRCIAVHPTQPFILTSS 118 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + +WD K + GHT + NP + S S D Sbjct: 119 D-DMLIKLWDWDKKWSCSQ-------------VFEGHTHYVMQIVINPKDNNQFASASLD 164 Query: 397 NIMQVWQMA 405 ++VWQ+ Sbjct: 165 RTIKVWQLG 173 >5OQL-d nrPDB Length = 446 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 58/116 (50%), Gaps = 5/116 (4%) Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 + DV ++ + S+ GSVA D+ ++++D R+N P H A N + FNP L Sbjct: 200 ITDVCFNQVETSVIGSVATDRSIILFDLRTN---MPVIKTVLHFA-CNRIVFNPMEAMNL 255 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 A S D + ++D RN L+ + H + V++SP E L S DR + +W Sbjct: 256 AVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLW 310 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 54/119 (45%), Gaps = 10/119 (8%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + +NP + +L AS+DH I ++D K A I GH A V DV + E L Sbjct: 245 IVFNPMEAMNLAVASEDHNIYIFDARNFDK------ALNIQKGHVAAVMDVEFSPTGEEL 298 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 S + D+ + +W + ++ H+ + + S++IL TGS D V LW Sbjct: 299 V-SGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMD--SKYIL-TGSDDGNVRLW 353 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 11/174 (6%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + Y + + N + S S D + +WD++ +E V A H +V+ ++ Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAA------HNNIVKGLT 117 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + L D KL WD ++ ++ + LSF+ S A S Sbjct: 118 F-TNDKKLLSCATDGIKL--WDPYASPSNTTPIATWQEGGPYTSLSFH-RSANTFAASSG 173 Query: 295 DKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + +WDL + + + S D I V ++ +++ S TDR + ++DL Sbjct: 174 QGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDL 227 >2H9P-A nrPDB Length = 329 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 112/232 (48%), Gaps = 26/232 (11%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 + GH+ ++W+ + S L+SASDD T+ +WD+S+ GK + GH+ V Sbjct: 78 ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSS----GKCLKT---LKGHSNYVFC 129 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +++ +L S + D+ + IWD + T K ++ AH+ V+ + FN I+++ Sbjct: 130 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 184 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D +WD + + + + V++SP+ + ILA++ D L +WD SK G+ Sbjct: 185 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GK 242 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 +F ++FS + W++ S SEDN++ +W + Sbjct: 243 CLKTYTGHKNEKYCIF---------ANFSVTGGK-WIV-SGSEDNLVYIWNL 283 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 69/145 (47%), Gaps = 22/145 (15%) Query: 264 KPSHSVD----AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 KP++++ HT V+ + F+P E+ LA+ SADK + +W + K + + HK Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLG 84 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 379 I V WS + +L S+ D+ L +WD+S + L GH+ + Sbjct: 85 ISDVAWSS-DSNLLVSASDDKTLKIWDVS--------------SGKCLKTLKGHSNYVFC 129 Query: 380 FSWNPNEPWVICSVSEDNIMQVWQM 404 ++NP +I S S D +++W + Sbjct: 130 CNFNPQSN-LIVSGSFDESVRIWDV 153 >4V7E-Bg nrPDB Length = 380 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 5/146 (3%) Query: 159 SKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD 218 S+ D G L GH+ + P+ L++ S D T LWD++ + + Sbjct: 139 SQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRIS--IF 196 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 +GHTA V +S + L+ ++F S + D + +WD R TS+ + H ++N Sbjct: 197 GSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRI--TSRAVRTYHGHEGDINS 254 Query: 279 LSFNPYSEFILATGSADKTVALWDLR 304 + F P + TGS D T L+D+R Sbjct: 255 VKFFPDGQR-FGTGSDDGTCRLFDMR 279 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 36/150 (24%), Positives = 64/150 (42%), Gaps = 4/150 (2%) Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR 258 D ++++S+ + + TGH + E+ + + DQ ++WD Sbjct: 129 DSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVT 188 Query: 259 SNNTSK--PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 316 + S HTA+V LS N + + +GS D TV LWDLR + ++ H Sbjct: 189 TGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGH 248 Query: 317 KDEIFQVQWSPHNETILASS--GTDRRLNV 344 + +I V++ P + S GT R ++ Sbjct: 249 EGDINSVKFFPDGQRFGTGSDDGTCRLFDM 278 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 85/195 (43%), Gaps = 21/195 (10%) Query: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 +V +T+ GH+ V + W ++ S + D +L++W+ TS+ +H++ H Sbjct: 56 LVCCRTL-QGHSGKVYSLDW-TPEKNWIVSASQDGRLIVWNAL---TSQKTHAIKLHCPW 110 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDL-----RNLKLKL-HSFESHKDEIFQVQWSPHN 329 V +F P + + A G D ++++L R+ + + HK Q+ P Sbjct: 111 VMECAFAPNGQSV-ACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQ 169 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 ET L + D+ +WD++ G+ S +E GHTA + S N + Sbjct: 170 ETRLITGSGDQTCVLWDVTT-GQRISIFGSE--------FPSGHTADVLSLSINSLNANM 220 Query: 390 ICSVSEDNIMQVWQM 404 S S D +++W + Sbjct: 221 FISGSCDTTVRLWDL 235 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHG--GHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 D+ K + Q P +L+ GH+ K+ W P + W++ S S+D + VW Sbjct: 36 DVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIV-SASQDGRLIVW 93 >6QX9-4B nrPDB Length = 522 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 87/178 (48%), Gaps = 16/178 (8%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASD-DHTICLWDISAVPKEGKVVDAKTIFTGHT 227 P + GH + W+P SG L + D + LWD+ A + +++ + GH+ Sbjct: 315 PVADIEGHTVRVARVMWHP--SGRFLGTTCYDRSWRLWDLEA---QEEILHQE----GHS 365 Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 V D+++H SL G+ D +WD R T + ++ H E+ ++F+P + + Sbjct: 366 MGVYDIAFHQ-DGSLAGTGGLDAFGRVWDLR---TGRCIMFLEGHLKEIYGINFSP-NGY 420 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 +ATGS D T +WDLR + +++ +H++ + V++ P + L + D +W Sbjct: 421 HIATGSGDNTCKVWDLRQRRC-VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477 >6HHQ-h nrPDB Length = 319 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 105/225 (46%), Gaps = 34/225 (15%) Query: 187 PNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG-S 245 PNL LLSAS D T+ W ++ ++ V F GH+ +V+D + L + + S Sbjct: 30 PNL---LLSASRDKTLISWKLTGDDQKFGV--PVRSFKGHSHIVQDCT--LTADGAYALS 82 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 + D+ L +WD + T + H ++V + + + I+ +GS DKT+ +W ++ Sbjct: 83 ASWDKTLRLWDVATGETYQ---RFVGHKSDVMSVDIDKKASMII-SGSRDKTIKVWTIKG 138 Query: 306 LKLKLHSFESHKDEIFQVQWSPH-----NETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 L + H D + QV+ P+ + + S+G D+ + W+L++ E Sbjct: 139 QCLA--TLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD----- 191 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 FI GH + I+ + +P+ +I S +D + +W +A Sbjct: 192 -------FI--GHNSNINTLTASPDGT-LIASAGKDGEIMLWNLA 226 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 64/134 (47%), Gaps = 12/134 (8%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 330 H + +N L+ +P I + G D + LW+L K +++ S +DE+F + +SP+ Sbjct: 194 GHNSNINTLTASPDGTLIASAGK-DGEIMLWNLAAKK-AMYTL-SAQDEVFSLAFSPNRY 250 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 390 + A++ T ++ D + ++ PE A G + H +W+ + + Sbjct: 251 WLAAATATGIKVFSLDPQYLVDDLRPEFA--GYSKAAEPHA------VSLAWSADGQTLF 302 Query: 391 CSVSEDNIMQVWQM 404 + DN+++VWQ+ Sbjct: 303 AGYT-DNVIRVWQV 315 >5GAN-H nrPDB Length = 465 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 82/183 (44%), Gaps = 10/183 (5%) Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 +L H + + W+P+ + ++S ++D I + S +EG + + GH + Sbjct: 213 KLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYS--NEEGGLRLLGDL-VGHERRIS 269 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 DV +H GS + D +WD +T + + H V LSF + + Sbjct: 270 DVKYHP-SGKFIGSASHDMTWRLWDA---STHQELLLQEGHDKGVFSLSFQCDGSLV-CS 324 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 G D LWD+R+ K+ + H I+ V WSP+ + A+ G D +NVWD+ K Sbjct: 325 GGMDSLSMLWDIRSGS-KVMTLAGHSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIRKRD 382 Query: 352 EEQ 354 E Q Sbjct: 383 EGQ 385 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 61/135 (45%), Gaps = 15/135 (11%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG---KVVDAKTIFTGHT 227 + L GH K Y ++W+PN + + D I +WDI EG +++ + I T Sbjct: 343 MTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINVWDIRK-RDEGQLNQILAHRNIVTQVR 400 Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 ED L+ S D + ++ S++T S+ HT ++ L + S F Sbjct: 401 FSKEDGGKKLV------SCGYDNLINVY---SSDTWLKMGSLAGHTDKIISLDISNNSHF 451 Query: 288 ILATGSADKTVALWD 302 L +G D+++ LW+ Sbjct: 452 -LVSGGWDRSIKLWN 465 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 11/117 (9%) Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 + ++ATGS + + + + L+ +SH +I + W P + + S D + + Sbjct: 187 DMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNF 246 Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 S E+G LL GH +ISD ++P+ + I S S D ++W Sbjct: 247 QYSN----------EEGGLRLLGDLVGHERRISDVKYHPSGKF-IGSASHDMTWRLW 292 >5XYI-g nrPDB Length = 335 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/179 (25%), Positives = 80/179 (44%), Gaps = 13/179 (7%) Query: 168 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 227 P RL GH +S + + S HLL++S D T+ LWD+S K +F GH Sbjct: 71 TPFTRLIGHNHFVSDVSLSRDAS-HLLTSSWDSTLRLWDLS-------TRTTKKLFLGHK 122 Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF-NPYSE 286 V V++ + + SV D ++ IW+ N K + V C + S Sbjct: 123 KDVLGVTFSPCNRRII-SVGRDNQVKIWNILGEN--KAELQCSSWVTSVACAPMADETSP 179 Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 ++A G D V +W + + F++H V ++P + ++ + G+DR++ +W Sbjct: 180 LVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVI-TGGSDRKVVMW 237 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 8/138 (5%) Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNT--SKPSHSVDAHTAEVN 277 + F GH A +E + H L S + D+ ++W + P + H V+ Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLV-SASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 +S + + +L T S D T+ LWDL K F HK ++ V +SP N I+ S G Sbjct: 85 DVSLSRDASHLL-TSSWDSTLRLWDLSTRTTK-KLFLGHKKDVLGVTFSPCNRRII-SVG 141 Query: 338 TDRRLNVWDLSKIGEEQS 355 D ++ +W++ +GE ++ Sbjct: 142 RDNQVKIWNI--LGENKA 157 >1VYH-C nrPDB Length = 410 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 87/175 (49%), Gaps = 19/175 (10%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH+ + ++P S ++SAS+D TI +WD + D + GHT V+D Sbjct: 104 LSGHRSPVTRVIFHPVFSV-MVSASEDATIKVWDY-------ETGDFERTLKGHTDSVQD 155 Query: 233 VSWHLLHE-SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 +S+ H L S + D + +WD + + H H V+ +S P + I++ Sbjct: 156 ISFD--HSGKLLASCSADMTIKLWDFQGFECIRTMH---GHDHNVSSVSIMPNGDHIVS- 209 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE-TILASSGTDRRLNVW 345 S DKT+ +W+++ + +F H++ + V+ P+ + T++AS D+ + VW Sbjct: 210 ASRDKTIKMWEVQT-GYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVW 261 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/158 (29%), Positives = 70/158 (44%), Gaps = 33/158 (20%) Query: 166 ECNPDLRLRGHQKEGYGLSWNPNLSG-------------------HLLSASDDHTICLWD 206 EC +LR H E +SW P S LLS S D TI +WD Sbjct: 267 ECKAELREHRHVVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 Query: 207 ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 +S G + GH V V +H + + S ADD+ L +WD ++ K Sbjct: 325 VST----GMCL---MTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVWDYKNKRCMK-- 374 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 +++AH V L F+ + +++ TGS D+TV +W+ R Sbjct: 375 -TLNAHEHFVTSLDFHKTAPYVV-TGSVDQTVKVWECR 410 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 100/250 (40%), Gaps = 48/250 (19%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 + GH +S PN H++SAS D TI +W++ + G V FTGH V Sbjct: 188 MHGHDHNVSSVSIMPN-GDHIVSASRDKTIKMWEV----QTGYCVKT---FTGHREWVRM 239 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF----- 287 V + +L S ++DQ + +W T + + H V C+S+ P S + Sbjct: 240 VRPN-QDGTLIASCSNDQTVRVWVV---ATKECKAELREHRHVVECISWAPESSYSSISE 295 Query: 288 --------------ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333 L +GS DKT+ +WD+ + + L + H + + V + + IL Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDV-STGMCLMTLVGHDNWVRGVLFHSGGKFIL 354 Query: 334 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV 393 S D+ L VWD + H ++ ++ P+V+ Sbjct: 355 -SCADDKTLRVWDYKN--------------KRCMKTLNAHEHFVTSLDFHKTAPYVVTG- 398 Query: 394 SEDNIMQVWQ 403 S D ++VW+ Sbjct: 399 SVDQTVKVWE 408 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 33/128 (25%), Positives = 68/128 (53%), Gaps = 7/128 (5%) Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279 K +GH + V V +H + S+ S ++D + +WD + + + ++ HT V + Sbjct: 101 KYALSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDFER---TLKGHTDSVQDI 156 Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 339 SF+ +S +LA+ SAD T+ LWD + + + + H + V P+ + I+++S D Sbjct: 157 SFD-HSGKLLASCSADMTIKLWDFQGFEC-IRTMHGHDHNVSSVSIMPNGDHIVSAS-RD 213 Query: 340 RRLNVWDL 347 + + +W++ Sbjct: 214 KTIKMWEV 221 >5OQL-L nrPDB Length = 557 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 8/115 (6%) Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS--EFILATG 292 W + S +DD+ + +WD SN+ P+ HT V C +F P S +L +G Sbjct: 152 WSPTELTTLMSCSDDKTVRLWDLPSND---PTRLFTGHTDYVRCGAFMPGSANSNLLVSG 208 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 S D+TV +WD R + +F+ H D I V P T+LA+SG ++V DL Sbjct: 209 SYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSGTTLLAASGNA--ISVLDL 260 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 9/86 (10%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H++ + W+P L+S SDD T+ LWD+ P D +FTGHT V ++ Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDL---PSN----DPTRLFTGHTDYVRCGAF 195 Query: 236 H--LLHESLFGSVADDQKLMIWDTRS 259 + +L S + D+ + +WD R+ Sbjct: 196 MPGSANSNLLVSGSYDETVRVWDARA 221 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 24/171 (14%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIF 321 +P ++ +E +C P ++A G + ++D+ + L ++ HK ++ Sbjct: 90 EPLKTIGRFDSEAHCGEIRPDGRVLVA-GEDTGRMQVFDVGQGTRAVILKTWHIHKQPVW 148 Query: 322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS 381 +WSP T L S D+ + +WDL P LF GHT + + Sbjct: 149 VTKWSPTELTTLMSCSDDKTVRLWDL------------PSNDPTRLFT--GHTDYVRCGA 194 Query: 382 WNPNEP--WVICSVSEDNIMQVWQM-----AENIYNDEDPEGSVDPEGQGS 425 + P ++ S S D ++VW A + DP V P G+ Sbjct: 195 FMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGT 245 Score = 31.6 bits (70), Expect = 0.65, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 43/107 (40%), Gaps = 5/107 (4%) Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-RNL 306 D ++ ++D + + H V ++P L + S DKTV LWDL N Sbjct: 119 DTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND 178 Query: 307 KLKLHSFESHKDEIFQVQWSP--HNETILASSGTDRRLNVWDLSKIG 351 +L F H D + + P N +L S D + VWD G Sbjct: 179 PTRL--FTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPG 223 >6ID0-T nrPDB Length = 514 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 43/255 (16%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 L L GH G+ + S +L S +D + WD+ + KV+ + GH + V Sbjct: 240 LSLTGHISTVRGVIVS-TRSPYLFSCGEDKQVKCWDL----EYNKVIRH---YHGHLSAV 291 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHT---AEVNCLSFNPYSEF 287 + H + L + + D IWD R T H++ HT A V C + P Sbjct: 292 YGLDLHPTIDVLV-TCSRDSTARIWDVR---TKASVHTLSGHTNAVATVRCQAAEPQ--- 344 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + TGS D T+ LWDL K ++ + +HK + V P + T +SG+ + W Sbjct: 345 -IITGSHDTTIRLWDLVAGKTRV-TLTNHKKSVRAVVLHPRHYTF--ASGSPDNIKQWKF 400 Query: 348 SKIGEEQSPEDAEDGPPELLFIH--GGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 P+ FI GH A I+ + N + V+ S +++ M +W Sbjct: 401 ----------------PDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWR 442 Query: 406 ENIYNDEDPEGSVDP 420 YN + +V P Sbjct: 443 TG-YNFQRVHAAVQP 456 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 18/134 (13%) Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 328 + H V C++ P +++ + TGSAD+T+ +WDL + KLKL S H + V S Sbjct: 200 ISGHLGWVRCIAVEPGNQWFV-TGSADRTIKIWDLASGKLKL-SLTGHISTVRGVIVSTR 257 Query: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388 + L S G D+++ WDL +++ + GH + + +P Sbjct: 258 SP-YLFSCGEDKQVKCWDLEY--------------NKVIRHYHGHLSAVYGLDLHPTID- 301 Query: 389 VICSVSEDNIMQVW 402 V+ + S D+ ++W Sbjct: 302 VLVTCSRDSTARIW 315 >3JB9-L nrPDB Length = 340 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 67/288 (23%), Positives = 112/288 (38%), Gaps = 52/288 (18%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVV----------- 217 P+L++ GH E ++P+ S + S D I LW++ K V+ Sbjct: 42 PNLQMFGHTAEVLVARFDPSGS-YFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQ 100 Query: 218 ---DAKTIFT----------------------GHTAVVEDVSWHLLHESLFGSVADDQKL 252 D++ ++ GH VV + + L SV+DD + Sbjct: 101 WSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTM 160 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 +WD+RS + K TA ++ FI G D + +WDLRN H Sbjct: 161 KVWDSRSKDCIKTIEEKYPLTAV--AIAQQGTQVFI---GGIDGAIKIWDLRNNHCS-HV 214 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + HKD I + S ++L++S D + ++D+ Q +G IH G Sbjct: 215 LKGHKDIITSLAISKDGSSLLSNS-MDNTVRIFDVKPFASAQRQLQIFEGA-----IH-G 267 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI-YNDEDPEGSVD 419 + +W+ N +V S+ N+ VW ++ Y EGSV+ Sbjct: 268 QEHNLLGVAWSRNSRFVGAGSSDKNVY-VWSATGDLRYVLPGHEGSVN 314 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 16/145 (11%) Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317 R+++ + P+ + HTAEV F+P + A+G D+ + LW++ K Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSY-FASGGMDRQILLWNVFGDVKNYGVLNGCK 93 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 I +QWS + + SS +D L W DA G + H GH + Sbjct: 94 GAITDLQWSRDSRVVYCSS-SDTHLMSW------------DAVSGQK--IRKHKGHAGVV 138 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVW 402 + ++ SVS+D M+VW Sbjct: 139 NALDVLKVGSELLTSVSDDCTMKVW 163 >5WLC-LU nrPDB Length = 489 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 77/202 (38%), Gaps = 54/202 (26%) Query: 193 LLSASDDHTICLWDI--------------SAVPKEG--KVVDAKTIFTG----------- 225 +LS SDD T+ LW I S +EG + D ++ F G Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFA 195 Query: 226 ------------HTAVVEDVSW----------HLLHESLFGSVADDQKLMIWDTRSNNTS 263 V D+SW + + S D ++++D R+N+ Sbjct: 196 TGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNS-- 253 Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 P+ + T N + +NP F T + D +D+RNL L+ F+ H + V Sbjct: 254 -PTQKI-VQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDV 311 Query: 324 QWSPHNETILASSGTDRRLNVW 345 +SP + I+ S D+ + ++ Sbjct: 312 DFSPTGDEIVTGS-YDKSIRIY 332 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 17/217 (7%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 L +N N + L S D++I L+D+ K+V T + W+ + Sbjct: 225 LKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV--------QTMRTNAICWNPMEAFN 276 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 F + +D +D R N S+ + H + V + F+P + I+ TGS DK++ ++ Sbjct: 277 FVTANEDHNAYYYDMR--NLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYK 333 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GTDR--RLNVWDLSKIGEEQSPED 358 + + +FQV++S ++ I++ S G R R W+ S + + Sbjct: 334 TNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNK 393 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 E E L H +I S + + P VI E Sbjct: 394 LE--YDEKLKERFRHMPEIKRISRHRHVPQVIKKAQE 428 >5OPT-p nrPDB Length = 318 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 101/218 (46%), Gaps = 27/218 (12%) Query: 194 LSASDDHTICLW--DISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD-DQ 250 +S S D+T+ W ++ +E + + GH+A V DV+ L + F A D Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVA--LSNNGDFAVSASWDH 89 Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310 L +W+ + T H HT +V ++F+P + I+ +G D + +W+++ L Sbjct: 90 SLRLWNLQ---TGVCQHKFLGHTKDVLSVTFSPDNRQIV-SGGRDNALRVWNVKGECLHT 145 Query: 311 HSFESHKDEIFQVQWSPHNET-ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 +H D + V++SP ET ++ S G D + VWD++ LL Sbjct: 146 LGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIAS--------------GRLLTD 191 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSE-DNIMQVWQMAE 406 GHT I+ + +P+ +C+ S+ D + ++W + + Sbjct: 192 LKGHTNYITSVTVSPDGS--LCASSDKDGVARLWDLTK 227 >5A9Q-0 nrPDB Length = 380 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 63/280 (22%), Positives = 113/280 (40%), Gaps = 27/280 (9%) Query: 103 GEFGGF---GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 159 G+FG G G ++ I H G+V ++ Q + A+ T V + HP+ Sbjct: 50 GDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTV----FLHHPN 105 Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW-DISAVPKEGKVVD 218 S H G G +P+ S SA +C +I V ++G++ Sbjct: 106 NQTLSVN---QQWTTAHYHTGPG---SPSYS----SAPCTGVVCNNPEIVTVGEDGRINL 155 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFG------SVADDQKLMIWDTRSNNTSKPSH--SVD 270 + +++ LH F +V +L IWD R ++PS S+ Sbjct: 156 FRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQG-NEPSQILSLT 214 Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 330 ++C+ +P + ++ATG D +++WD+R + + ++H+ E+++V + P N Sbjct: 215 GDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNP 274 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 L + D L WD S E+S + G H Sbjct: 275 EHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSH 314 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 24/114 (21%), Positives = 51/114 (44%), Gaps = 16/114 (14%) Query: 298 VALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 + +WD R N ++ S + + V P+ + ++A+ G D L++WD+ + Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQ----- 249 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 P LL H A++ + ++P+ P + + SED + W + ++ Sbjct: 250 -----GTMPVSLL---KAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDV 295 >4AEZ-A nrPDB Length = 401 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 88/190 (46%), Gaps = 19/190 (10%) Query: 166 ECNPDLR-LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 224 E LR + GHQ LSWN ++ L S S I D+ + + Sbjct: 164 ESQTKLRTMAGHQARVGCLSWNRHV---LSSGSRSGAIHHHDVRIANHQIGTLQ------ 214 Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284 GH++ V ++W L S +D + IWD RS S P + H A V +++ P+ Sbjct: 215 GHSSEVCGLAWRSDGLQL-ASGGNDNVVQIWDARS---SIPKFTKTNHNAAVKAVAWCPW 270 Query: 285 SEFILAT--GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRR 341 +LAT G+ DK + W+ ++++ ++ ++ + WSPH++ I+++ G D Sbjct: 271 QSNLLATGGGTMDKQIHFWNAAT-GARVNTVDA-GSQVTSLIWSPHSKEIMSTHGFPDNN 328 Query: 342 LNVWDLSKIG 351 L++W S G Sbjct: 329 LSIWSYSSSG 338 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/162 (25%), Positives = 67/162 (41%), Gaps = 24/162 (14%) Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLM-IWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 T + V V W H+ F SV L+ I+D S + ++ H A V CLS+N Sbjct: 131 TDESTYVASVKWS--HDGSFLSVGLGNGLVDIYDVESQTKLR---TMAGHQARVGCLSWN 185 Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 + +L++GS + D+R ++ + + H E+ + W + LAS G D + Sbjct: 186 RH---VLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRS-DGLQLASGGNDNVV 241 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384 +W DA P+ F H A + +W P Sbjct: 242 QIW------------DARSSIPK--FTKTNHNAAVKAVAWCP 269 >5FA5-B nrPDB Length = 367 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 82/169 (48%), Gaps = 10/169 (5%) Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 R H + ++ +P+ LS S+D+ I LWD + PK + G+ + + Sbjct: 189 RAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSA--PGY--LPTSL 243 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 +WH +F ++ + + DT+S + S H+ V L F+P+S LA+ S Sbjct: 244 AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLS 300 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 D ++A+ D +L +L ++H+D + WSP N ++L + G D ++ Sbjct: 301 EDCSLAVLD-SSLS-ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 84/193 (43%), Gaps = 28/193 (14%) Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253 +S S D I +WD++ +VV + + H A V V+ +S+F S ++D +++ Sbjct: 166 VSGSKDICIKVWDLAQ-----QVVLSS--YRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 218 Query: 254 IWDTRSNNTSKPSHSVDAHTAEV--NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 +WDTR KP+ + L+++P + G + TV+L D ++ L Sbjct: 219 LWDTR---CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS 275 Query: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371 S H + + +SPH+ LAS D L V D S + E LF Sbjct: 276 S-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD-SSLSE--------------LFRSQ 319 Query: 372 GHTAKISDFSWNP 384 H + D +W+P Sbjct: 320 AHRDFVRDATWSP 332 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 24/178 (13%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLW---DISAVPKEGKVVDAKTIFTGHTAVVED 232 ++ +G L +LSG + S LW D A P EG G V D Sbjct: 61 YRSDGALLLGASSLSGRCWAGS------LWLFKDPCAAPNEGFCSAGVQTEAG----VAD 110 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV----DAHTAEVNCLSFNPYSEFI 288 ++W + E +D + +W+ N T S D + V+ LS + Sbjct: 111 LTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA--- 165 Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 166 -VSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Score = 35.4 bits (80), Expect = 0.050, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 +L ASD + LW++ + ++ +K H +V VS L + S + D + Sbjct: 119 ILVASDSGAVELWELD---ENETLIVSKFCKYEHDDIVSTVS-VLSSGTQAVSGSKDICI 174 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 +WD S AH A+V C++ +P+ + + + S D + LWD R K Sbjct: 175 KVWDLAQQVVLS---SYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 226 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 16/116 (13%) Query: 289 LATGSADKTVALWDL-RNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 346 + S V LW+L N L + F ++ D+I + T S D + VWD Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 L++ +L + H A+++ + +P++ V S SEDN + +W Sbjct: 179 LAQ--------------QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 220 >5WYJ-BC nrPDB Length = 817 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 42/224 (18%) Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL----HESLFGSVADDQ 250 +AS D+T +W + + D + GH+A V V + + + ++D Sbjct: 405 TASKDNTAIVWRYN---ENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDL 461 Query: 251 KLMIWDTRSNNTSKPSHSVD------------AHTAEVNCLSFNPYSEFILATGSADKTV 298 + W KP+ S+D AH ++N LS +P ++ I AT S DKT Sbjct: 462 TIKKWII-----PKPTASMDVQIIKVSEYTRHAHEKDINALSVSP-NDSIFATASYDKTC 515 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 +W+L N +L+ + +HK ++ V + +++ +LA+S D+ + +W L ++ E Sbjct: 516 KIWNLENGELE-ATLANHKRGLWDVSFCQYDK-LLATSSGDKTVKIWSLDTFSVMKTLE- 572 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 GHT + S+ + +I S D ++++W Sbjct: 573 -------------GHTNAVQRCSFINKQKQLI-SCGADGLIKIW 602 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 15/96 (15%) Query: 257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 316 RS S PS+ +DA + +LA G D ++ + D+ N + HSF+ H Sbjct: 96 VRSMKISSPSYILDADSTST-----------LLAVGGTDGSIIVVDIENGYIT-HSFKGH 143 Query: 317 KDEIFQVQWSPHNET---ILASSGTDRRLNVWDLSK 349 I +++ + +LAS T+ + VWDL K Sbjct: 144 GGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK 179 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 79/188 (42%), Gaps = 27/188 (14%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 L ++S D T+ +W + GHT V+ S+ + L S D + Sbjct: 548 LATSSGDKTVKIWSLDTFS-------VMKTLEGHTNAVQRCSFINKQKQLI-SCGADGLI 599 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD---------- 302 IWD S K ++D H + LS + I++ AD W Sbjct: 600 KIWDCSSGECLK---TLDGHNNRLWALSTMNDGDMIVS-ADADGVFQFWKDCTEQEIEEE 655 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK--IGEEQSPEDAE 360 KL++ +S ++ + + W+ N +LA + D + ++++ K +GE +S +D E Sbjct: 656 QEKAKLQVEQEQSLQNYMSKGDWT--NAFLLAMT-LDHPMRLFNVLKRALGESRSRQDTE 712 Query: 361 DGPPELLF 368 +G E++F Sbjct: 713 EGKIEVIF 720 >5OQL-J nrPDB Length = 912 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 80/213 (37%), Gaps = 52/213 (24%) Query: 158 PSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKV 216 P + G+ LR H K+ L +PN G L SAS D T+ +WD+ + +G Sbjct: 525 PRQLQKGGKLTSSLRRLAHDKDINALDISPN--GKLFASASQDKTVKIWDVEKLEVQG-- 580 Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 I GH K +W R + P + V Sbjct: 581 -----ILRGH------------------------KRGVWTVRFAPLNTP--VIQGEQGSV 609 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW--------SPH 328 + ++ TGS DKT+ LW+L + + +FE H + +V W Sbjct: 610 S-------GRGVVLTGSGDKTIKLWNLSDYTC-IRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 + AS+G D + VWD + E + ++ ED Sbjct: 662 TKVQFASAGADTLVKVWDANTGETECTLDNHED 694 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 7/116 (6%) Query: 249 DQKLMIWDTRSNNTS----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 D ++ I+D T+ P +AH + V C++++P + L +GS DKT+ LW R Sbjct: 204 DGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP-EQHALLSGSRDKTMTLWLWR 262 Query: 305 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + + H E+ + + + S+GT L +WD + E +DA+ Sbjct: 263 DGIWQGTPMLRH--ELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAK 316 >5L9T-R nrPDB Length = 493 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 72/154 (46%), Gaps = 24/154 (15%) Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL- 310 + IWD + K ++ HTA V L++N L++GS D+ + D+R L+ Sbjct: 253 VQIWDAAAG---KKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTPPLQSE 306 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 + H+ E+ ++WS ++ +LAS G D +L VW+ S + Q + Sbjct: 307 RRLQGHRQEVCGLKWSTDHQ-LLASGGNDNKLLVWNHSSLSPVQQYTE------------ 353 Query: 371 GGHTAKISDFSWNPNEPWVICS--VSEDNIMQVW 402 H A + +W+P++ ++ S + D ++ W Sbjct: 354 --HLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/147 (25%), Positives = 69/147 (46%), Gaps = 15/147 (10%) Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN 261 + +WD +A GK + ++ GHTA V ++W+ S + D+ ++ D R+ Sbjct: 253 VQIWDAAA----GKKL---SMLEGHTARVGALAWN---AEQLSSGSRDRMILQRDIRTPP 302 Query: 262 TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321 + + H EV L ++ + +LA+G D + +W+ +L + + H + Sbjct: 303 L-QSERRLQGHRQEVCGLKWSTDHQ-LLASGGNDNKLLVWNHSSLS-PVQQYTEHLAAVK 359 Query: 322 QVQWSPHNETILASSG--TDRRLNVWD 346 + WSPH +LAS G DR + W+ Sbjct: 360 AIAWSPHQHGLLASGGGTADRCIRFWN 386 >3BG0-A nrPDB Length = 316 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 20/128 (15%) Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDE 319 NT SH H A+++ Y LAT S+D++V ++D+RN ++ + H+ Sbjct: 6 NTVDTSHEDMIHDAQMD------YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 Query: 320 IFQVQWS-PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 378 ++QV W+ P ILAS DR++ +W E+G E H GH + ++ Sbjct: 60 VWQVAWAHPMYGNILASCSYDRKVIIWR------------EENGTWEKSHEHAGHDSSVN 107 Query: 379 DFSWNPNE 386 W P++ Sbjct: 108 SVCWAPHD 115 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 16/167 (9%) Query: 221 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 280 T+ T H ++ D + + + + D+ + I+D R N + H V ++ Sbjct: 7 TVDTSHEDMIHDAQ-MDYYGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGPVWQVA 64 Query: 281 F-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSG 337 + +P ILA+ S D+ V +W N K H H + V W+PH+ ILA Sbjct: 65 WAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384 +D +++ L+ GE G E+ I+ HT + SW P Sbjct: 125 SDGAISL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAP 160 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 65/277 (23%), Positives = 104/277 (37%), Gaps = 43/277 (15%) Query: 113 GKIEIEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 G+I I HEG V + + P I+A+ + V+++ + +G Sbjct: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW--------REENGTWEKSH 97 Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSA-SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 GH + W P+ G +L+ S D I L + EG+ + K I HT Sbjct: 98 EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG---EGQW-EVKKINNAHTIGC 153 Query: 231 EDVSWH--LLHESL--------------FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 VSW ++ SL F S D + +W + K ++AH+ Sbjct: 154 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSD 213 Query: 275 EVNCLSFNPYSEF---ILATGSADKTVALWDLRNLKLK------LHSFESHKDEIFQVQW 325 V +++ P +A+ S D V +W + LH F D ++ V W Sbjct: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKF---NDVVWHVSW 270 Query: 326 SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 S ILA SG D ++ +W S G+ D G Sbjct: 271 SI-TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 >2PM9-A nrPDB Length = 416 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 57/260 (21%), Positives = 106/260 (40%), Gaps = 30/260 (11%) Query: 168 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 227 N R H + +N L S ++ I +WD++ + T + Sbjct: 104 NSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMS 163 Query: 228 AVVEDVS--WHLLHESLFGSVADDQKLMIWDTRSN------NTSKPSHSVDAHTAEVNCL 279 +V E +S W+ +F S IWD ++ + + P+ + +++ + Sbjct: 164 SVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQ---QLSVV 220 Query: 280 SFNPYSEFILATGSA---DKTVALWDLRNLKLKLHSF-ESHKDEIFQVQWSPHNETILAS 335 ++P + +AT + D ++ +WDLRN L + + H+ I + W +E +L S Sbjct: 221 EWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLS 280 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 SG D + +W+ PE AE F G+ + F+ P P + S Sbjct: 281 SGRDNTVLLWN---------PESAEQLSQ---FPARGNWCFKTKFA--PEAPDLFACASF 326 Query: 396 DNIMQVWQMAENIYNDEDPE 415 DN ++V Q +N+ N D + Sbjct: 327 DNKIEV-QTLQNLTNTLDEQ 345 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 36/164 (21%), Positives = 71/164 (43%), Gaps = 23/164 (14%) Query: 197 SDDHTICLWDISAVPKEGKV----VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 S D ++ LW + A E + VD+K D+ W ++ + G++ D+ L Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSK---------FNDLDWSHNNKIIAGAL-DNGSL 91 Query: 253 MIWDTR-SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 ++ T +NN H++ V + FN + +LA+G + + +WD+ Sbjct: 92 ELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPS 151 Query: 312 SFE--------SHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 ++ S DE+ + W+ + AS+G+ ++WDL Sbjct: 152 NYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDL 195 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 32/164 (19%), Positives = 71/164 (43%), Gaps = 10/164 (6%) Query: 244 GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW-- 301 + + D L +W + ++ KP S+ + + N L ++ ++ I+A + ++ L+ Sbjct: 39 ANFSTDSSLELWSLLAADSEKPIASLQVDS-KFNDLDWS-HNNKIIAGALDNGSLELYST 96 Query: 302 -DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + N + F +H + V+++ + +LAS G + + +WD++K E SP + Sbjct: 97 NEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTE--SPSNYT 154 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 P ++ +WN + V S N +W + Sbjct: 155 PLTPGQSM---SSVDEVISLAWNQSLAHVFASAGSSNFASIWDL 195 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 17/98 (17%) Query: 126 EVNRARYMPQNPCIIATKTPSSD---VLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 +++ + P+N +AT T S + +L++D + P N +GHQK Sbjct: 216 QLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANT---PLQTLN-----QGHQKGILS 267 Query: 183 LSWNPNLSGHLLSASDDHTICLWD------ISAVPKEG 214 L W LLS+ D+T+ LW+ +S P G Sbjct: 268 LDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARG 305 >6ELZ-p nrPDB Length = 460 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 74/158 (46%), Gaps = 19/158 (12%) Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI 254 S S DHTI WD+ + +D +T ++ + + +LL GS A + + + Sbjct: 305 SVSQDHTIKTWDLVT----ARCIDTRTTSYSLLSIAQLSTLNLLA---CGSSA--RHITL 355 Query: 255 WDTRSNNTSKPSHS-VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313 D R +SK + + H V+ L P +E+IL +GS D TV +WD+R+ Sbjct: 356 HDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTIT 415 Query: 314 ESHK-------DEIFQVQWSPHNETILASSGTDRRLNV 344 K D++F V+W+ I S+G D+++ + Sbjct: 416 REDKSVQKGVNDKVFAVKWAEKVGII--SAGQDKKIQI 451 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 82/212 (38%), Gaps = 47/212 (22%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK------------ 220 L GH+ + + N +LSAS D++I W S + KE VVD Sbjct: 204 LEGHKAPVVSIDVSDN--SRILSASYDNSIGFW--STIYKEMTVVDPLEDINNPNNKIST 259 Query: 221 ---------------------TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS 259 ++ HTA VE V + ++ SV+ D + WD + Sbjct: 260 AARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVT 319 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLR---NLKLKLHSFES 315 + +D T + LS S +LA GS+ + + L D R + K+ Sbjct: 320 ------ARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIG 373 Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 HK+ + + P NE IL S D + VWD+ Sbjct: 374 HKNFVSSLDTCPENEYILCSGSHDGTVKVWDV 405 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 39/125 (31%), Positives = 55/125 (44%), Gaps = 19/125 (15%) Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW--- 345 + +GS D V WDL K +S H I V++ + T L S+G DR L +W Sbjct: 118 IISGSYDGIVRTWDLSGNVQKQYS--GHSGPIRAVKYISN--TRLVSAGNDRTLRLWKTK 173 Query: 346 --DLSKIGEEQSPE------DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 DL ++Q+ E + EDG + L I GH A + + N I S S DN Sbjct: 174 NDDLKLTSQQQAQEDDDDEVNIEDG--KTLAILEGHKAPVVSIDVSDNSR--ILSASYDN 229 Query: 398 IMQVW 402 + W Sbjct: 230 SIGFW 234 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 16/72 (22%), Positives = 36/72 (50%), Gaps = 10/72 (13%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 S H++S S D + WD+S + + ++GH+ + V + + + S +D Sbjct: 115 SKHIISGSYDGIVRTWDLSG--------NVQKQYSGHSGPIRAVKY--ISNTRLVSAGND 164 Query: 250 QKLMIWDTRSNN 261 + L +W T++++ Sbjct: 165 RTLRLWKTKNDD 176 >5Z56-q nrPDB Length = 504 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 26/179 (14%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 +R H+ GLS + +LLS+SDD DI + G+V+ T T T+ Sbjct: 302 VRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDI----QTGRVL---TKVTDETSGCSL 353 Query: 233 VSWHLLHESL-FGSVADDQKLMIWDT--RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 + L FG+ D ++ IWD R+N + P HS + ++F+ + + L Sbjct: 354 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS-----GPITSIAFSE-NGYYL 407 Query: 290 ATGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 AT + D +V LWDLR LK L+L + K IF + T LA GTD ++ + Sbjct: 408 ATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-----QSGTYLALGGTDVQIYI 461 >4BH6-A nrPDB Length = 308 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%) Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 +GH V +SW+ + S + D +++ D R + ++++HT EV L +N Sbjct: 100 LSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPD--PFFETIESHTQEVCGLKWN 154 Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG--TDR 340 ++ LA+G D V +++ + K + +F+ HK + + WSPH +LA+ G DR Sbjct: 155 -VADNKLASGGNDNVVHVYEGTS-KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADR 212 Query: 341 RLNVWDLS 348 RL +W+++ Sbjct: 213 RLKIWNVN 220 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 58/257 (22%), Positives = 100/257 (38%), Gaps = 38/257 (14%) Query: 103 GEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 G G +G +EI + + G ++R + N ++ + + +L D Sbjct: 74 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDV-- 131 Query: 157 HPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 PDP E + H +E GL WN L S +D+ + ++ EG Sbjct: 132 --RMPDPFFET-----IESHTQEVCGLKWNV-ADNKLASGGNDNVVHVY-------EGTS 176 Query: 217 VDAKTIFTGHTAVVEDVSW--HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 F H A V+ ++W H G D++L IW+ NTS +D+ + Sbjct: 177 KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNV---NTSIKMSDIDSGSQ 233 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNE 330 N + +E + + G + + LWD ++ LK HSF + + S Sbjct: 234 ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSF-----RVLHLTLSNDGT 288 Query: 331 TILASSGTDRRLNVWDL 347 T+++ +G D L W L Sbjct: 289 TVVSGAG-DETLRYWKL 304 >2YNP-A nrPDB Length = 604 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 81/188 (43%), Gaps = 36/188 (19%) Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 +DD ++ +++ NT + +AH + ++ +P ++L+ GS D TV LW+ N Sbjct: 74 SDDFRIRVFNY---NTGEKVVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLWNWENN 129 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK--------IGEEQSPED 358 +FE H+ + V ++P + + AS DR + VW L + G+E+ Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNY 189 Query: 359 AEDGP----PELLFIHGGHTAKISDFS-------------------WNPNEPWVICSVSE 395 + P P ++ T KI D+ ++P P +I S SE Sbjct: 190 VDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSE 248 Query: 396 DNIMQVWQ 403 D +++W Sbjct: 249 DGTLKIWN 256 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 13/166 (7%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 ++LS SDD T+ LW+ E +T F GH V V+++ S F S D+ Sbjct: 111 YVLSGSDDLTVKLWNW-----ENNWALEQT-FEGHEHFVMCVAFNPKDPSTFASGCLDRT 164 Query: 252 LMIWDTRSNNTSKPSHSV-DAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLRNLKLK 309 + +W S S P+ ++ VN + + P + + T S D T+ +WD + K Sbjct: 165 VKVW---SLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSC 220 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 + + E H + + P I++ S D L +W+ S E++ Sbjct: 221 VATLEGHMSNVSFAVFHPTLPIIISGS-EDGTLKIWNSSTYKVEKT 265 Score = 31.2 bits (69), Expect = 0.94, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 35/169 (20%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG-- 180 HE V + P++P A+ V V+ G+ P+ L Q+ G Sbjct: 139 HEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL----------GQSTPNFTLTTGQERGVN 188 Query: 181 ----YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 Y L P ++++ASDD TI +WD + GH + +VS+ Sbjct: 189 YVDYYPLPDKP----YMITASDDLTIKIWDY-------QTKSCVATLEGH---MSNVSFA 234 Query: 237 LLHESL--FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 + H +L S ++D L IW++ +T K +++ C++ +P Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNS---STYKVEKTLNVGLERSWCIATHP 280 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 17/123 (13%) Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL- 347 + GS D + +++ N K+ FE+H D I + P +L+ S D + +W+ Sbjct: 70 IIVGSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS-DDLTVKLWNWE 127 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + EQ+ E GH + ++NP +P S D ++VW + ++ Sbjct: 128 NNWALEQTFE--------------GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQS 173 Query: 408 IYN 410 N Sbjct: 174 TPN 176 >5A31-R nrPDB Length = 386 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%) Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 +GH V +SW+ + S + D +++ D R + ++++HT EV L +N Sbjct: 169 LSGHIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPD--PFFETIESHTQEVCGLKWN 223 Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG--TDR 340 ++ LA+G D V +++ + K + +F+ HK + + WSPH +LA+ G DR Sbjct: 224 -VADNKLASGGNDNVVHVYEGTS-KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADR 281 Query: 341 RLNVWDLS 348 RL +W+++ Sbjct: 282 RLKIWNVN 289 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 58/257 (22%), Positives = 100/257 (38%), Gaps = 38/257 (14%) Query: 103 GEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 G G +G +EI + + G ++R + N ++ + + +L D Sbjct: 143 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDV-- 200 Query: 157 HPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 PDP E + H +E GL WN L S +D+ + ++ EG Sbjct: 201 --RMPDPFFET-----IESHTQEVCGLKWNV-ADNKLASGGNDNVVHVY-------EGTS 245 Query: 217 VDAKTIFTGHTAVVEDVSW--HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 F H A V+ ++W H G D++L IW+ NTS +D+ + Sbjct: 246 KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNV---NTSIKMSDIDSGSQ 302 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNE 330 N + +E + + G + + LWD ++ LK HSF + + S Sbjct: 303 ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSF-----RVLHLTLSNDGT 357 Query: 331 TILASSGTDRRLNVWDL 347 T+++ +G D L W L Sbjct: 358 TVVSGAG-DETLRYWKL 373 >3JRP-A nrPDB Length = 379 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 107/274 (39%), Gaps = 55/274 (20%) Query: 173 LRGHQKEGYGLSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 L GH+ + + W +P L S S D + +W +E + H+A V Sbjct: 51 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 105 Query: 232 DVSWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---- 285 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 106 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 163 Query: 286 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 329 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 164 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 220 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 388 + LAS DR +W +D E GP + + K D W + W Sbjct: 221 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 265 Query: 389 ----VICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 V+ DN + +W+ EN+ +P G V Sbjct: 266 LSGNVLALSGGDNKVTLWK--ENLEGKWEPAGEV 297 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 17/123 (13%) Query: 289 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 346 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVWQM 404 E+G + +H H+A ++ W P+E P ++ + S D + V + Sbjct: 86 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA-SSDGKVSVVEF 132 Query: 405 AEN 407 EN Sbjct: 133 KEN 135 >4BZK-B nrPDB Length = 297 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 107/274 (39%), Gaps = 55/274 (20%) Query: 173 LRGHQKEGYGLSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 L GH+ + + W +P L S S D + +W +E + H+A V Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 103 Query: 232 DVSWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---- 285 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 104 SVQW-APHEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 Query: 286 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 329 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 388 + LAS DR +W +D E GP + + K D W + W Sbjct: 219 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 263 Query: 389 ----VICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 V+ DN + +W+ EN+ +P G V Sbjct: 264 LSGNVLALSGGDNKVTLWK--ENLEGKWEPAGEV 295 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 17/123 (13%) Query: 289 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 346 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVWQM 404 E+G + +H H+A ++ W P+E P ++ S D + V + Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGP-LLLVASSDGKVSVVEF 130 Query: 405 AEN 407 EN Sbjct: 131 KEN 133 >4LG8-A nrPDB Length = 354 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 26/179 (14%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 +R H+ GLS + +LLS+SDD DI + G+V+ T T T+ Sbjct: 152 VRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDI----QTGRVL---TKVTDETSGCSL 203 Query: 233 VSWHLLHESL-FGSVADDQKLMIWDT--RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 + L FG+ D ++ IWD R+N + P HS + ++F+ + + L Sbjct: 204 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS-----GPITSIAFSE-NGYYL 257 Query: 290 ATGSADKTVALWDLRNLK----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 AT + D +V LWDLR LK L+L + K IF + T LA GTD ++ + Sbjct: 258 ATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-----QSGTYLALGGTDVQIYI 311 >3JB9-g nrPDB Length = 558 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 42/76 (55%), Gaps = 1/76 (1%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 330 HT ++CL F P S +L +GS D + +W++ + + L +F+ H I + +S Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 331 TILASSGTDRRLNVWD 346 + L++S D+ + +WD Sbjct: 324 SFLSTS-FDKTIKLWD 338 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 98/236 (41%), Gaps = 31/236 (13%) Query: 174 RGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 +GH K L + P +SGHLL S S D+ I +W++ + F GH + D Sbjct: 263 KGHTKGISCLRFFP-ISGHLLLSGSMDNQIKIWEVYHDRSLLRT------FQGHARPIRD 315 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF--NPYSEFILA 290 +S+ S F S + D+ + +WDT +S D T NC+ F +P Sbjct: 316 LSFSQDGRS-FLSTSFDKTIKLWDTELGKCLNCFNS-DRLT---NCVKFQVDPDKPNEFL 370 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 G+ADK + +D+R+ + + +++ H I + + + + + +S D + W+ Sbjct: 371 AGTADKRILQFDIRSPDI-VQAYDHHLGGINSITFLENGKRFVTTS-DDSSMRFWEYGT- 427 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 P + F+ + + PN + C S DN + V+ E Sbjct: 428 ------------PVPIKFVADIAMHSMPRVALRPNGKSIACQ-SLDNCIYVYSAYE 470 >3MKQ-A nrPDB Length = 814 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 72/156 (46%), Gaps = 16/156 (10%) Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 +DD ++ +++ NT + +AH + ++ +P ++L+ GS D TV LW+ N Sbjct: 74 SDDFRIRVFNY---NTGEKVVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLWNWENN 129 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 +FE H+ + V ++P + + AS DR + VW L + P Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL-----------GQSTPNFT 178 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 L D+ P++P++I + S+D +++W Sbjct: 179 LTTGQERGVNYVDYYPLPDKPYMITA-SDDLTIKIW 213 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 13/166 (7%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 ++LS SDD T+ LW+ E +T F GH V V+++ S F S D+ Sbjct: 111 YVLSGSDDLTVKLWNW-----ENNWALEQT-FEGHEHFVMCVAFNPKDPSTFASGCLDRT 164 Query: 252 LMIWDTRSNNTSKPSHSV-DAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLRNLKLK 309 + +W S S P+ ++ VN + + P + + T S D T+ +WD + K Sbjct: 165 VKVW---SLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSC 220 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 + + E H + + P I++ S D L +W+ S E++ Sbjct: 221 VATLEGHMSNVSFAVFHPTLPIIISGS-EDGTLKIWNSSTYKVEKT 265 Score = 31.2 bits (69), Expect = 0.87, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 35/169 (20%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG-- 180 HE V + P++P A+ V V+ G+ P+ L Q+ G Sbjct: 139 HEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL----------GQSTPNFTLTTGQERGVN 188 Query: 181 ----YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 Y L P ++++ASDD TI +WD + GH + +VS+ Sbjct: 189 YVDYYPLPDKP----YMITASDDLTIKIWDY-------QTKSCVATLEGH---MSNVSFA 234 Query: 237 LLHESL--FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 + H +L S ++D L IW++ +T K +++ C++ +P Sbjct: 235 VFHPTLPIIISGSEDGTLKIWNS---STYKVEKTLNVGLERSWCIATHP 280 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 40/195 (20%), Positives = 78/195 (40%), Gaps = 22/195 (11%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 +D K F+ + V+ + +H + ++ ++ IW+ T S+ V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSG-RVEIWNYE---TQVEVRSIQVTETPV 58 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 F +I+ GS D + +++ N K+ FE+H D I + P +L+ S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 337 GTDRRLNVWDL-SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 D + +W+ + EQ+ E GH + ++NP +P S Sbjct: 117 -DDLTVKLWNWENNWALEQTFE--------------GHEHFVMCVAFNPKDPSTFASGCL 161 Query: 396 DNIMQVWQMAENIYN 410 D ++VW + ++ N Sbjct: 162 DRTVKVWSLGQSTPN 176 >1NR0-A nrPDB Length = 611 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 69/141 (48%), Gaps = 13/141 (9%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L G + + + P+ ++S SDD+T+ ++ EG K+ F HT V Sbjct: 143 LTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF-------EGPPFKFKSTFGEHTKFVHS 195 Query: 233 VSWHLLHESLFGSVADDQKLMIWD----TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V ++ SLF S D +++++ T++ S AH+ V L+++P I Sbjct: 196 VRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 Query: 289 LATGSADKTVALWDLRNLKLK 309 A+ SADKT+ +W++ LK++ Sbjct: 255 -ASASADKTIKIWNVATLKVE 274 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/238 (22%), Positives = 109/238 (45%), Gaps = 36/238 (15%) Query: 190 SGHLLSASDDH-TICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 248 SG+ ++ D H + +WD + K +F+G V+D+SW + + +V + Sbjct: 70 SGYYCASGDVHGNVRIWDTTQTTHILKTTIP--VFSGP---VKDISWDSESKRI-AAVGE 123 Query: 249 DQK----LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 ++ + ++DT ++N ++ +N + F P F + +GS D TVA+++ Sbjct: 124 GRERFGHVFLFDTGTSN-----GNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGP 178 Query: 305 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW---DLSKIG--EEQSPEDA 359 K K +F H + V+++P + ++ AS+G D + ++ D +K G E+ S ++ Sbjct: 179 PFKFK-STFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNV 236 Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 H+ + +W+P+ I S S D +++W +A P G+ Sbjct: 237 ------------AHSGSVFGLTWSPDGT-KIASASADKTIKIWNVATLKVEKTIPVGT 281 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 15/110 (13%) Query: 246 VADDQ--KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 VA DQ K++ + +N ++S HTA+V C+S++P LATGS D +V +W++ Sbjct: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNM 565 Query: 304 RN------LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + H+ S + V W NET + S+G D + W++ Sbjct: 566 NKPSDHPIIIKGAHAMSS----VNSVIW--LNETTIVSAGQDSNIKFWNV 609 >3JRO-A nrPDB Length = 753 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 107/274 (39%), Gaps = 55/274 (20%) Query: 173 LRGHQKEGYGLSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 L GH+ + + W +P L S S D + +W +E + H+A V Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW-----KEENGRWSQIAVHAVHSASVN 103 Query: 232 DVSWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---- 285 V W HE L + D K+ + + + N T+ P +DAH VN S+ P + Sbjct: 104 SVQWAP-HEYGPLLLVASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEED 161 Query: 286 ----------EFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQVQWSPHN-- 329 +F+ TG AD V +W D + L+ + E H D + V WSP Sbjct: 162 GEHNGTKESRKFV--TGGADNLVKIWKYNSDAQTYVLE-STLEGHSDWVRDVAWSPTVLL 218 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW- 388 + LAS DR +W +D E GP + + K D W + W Sbjct: 219 RSYLASVSQDRTCIIW----------TQDNEQGPWKKTLL---KEEKFPDVLWRAS--WS 263 Query: 389 ----VICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 V+ DN + +W+ EN+ +P G V Sbjct: 264 LSGNVLALSGGDNKVTLWK--ENLEGKWEPAGEV 295 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 17/123 (13%) Query: 289 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 346 LAT S+DKT+ ++++ KL + H+ +++V W+ P TILAS D ++ +W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVWQM 404 E+G + +H H+A ++ W P+E P ++ + S D + V + Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA-SSDGKVSVVEF 130 Query: 405 AEN 407 EN Sbjct: 131 KEN 133 >2HES-X nrPDB Length = 330 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 35/129 (27%), Positives = 63/129 (48%), Gaps = 16/129 (12%) Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSF---ESHKDEIFQVQWSPHNETILASSGTDR 340 +S+ ILATGS D+ + L ++ L +HK I V W PH ++LA+ D Sbjct: 22 FSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT-SLLAAGSFDS 80 Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPE--LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 +++W + E++ D E LL I GH ++ +W+ N+ + + + S D Sbjct: 81 TVSIW---------AKEESADRTFEMDLLAIIEGHENEVKGVAWS-NDGYYLATCSRDKS 130 Query: 399 MQVWQMAEN 407 + +W+ E+ Sbjct: 131 VWIWETDES 139 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 89/201 (44%), Gaps = 28/201 (13%) Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS----VDAHTAEVNCL 279 T H + V+W H SL + + D + IW + ++ H EV + Sbjct: 55 TAHKKAIRSVAWRP-HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGV 113 Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILASS 336 +++ + LAT S DK+V +W+ + + + H ++ V W P +E +LASS Sbjct: 114 AWSN-DGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP-SEALLASS 171 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI--SDFSWNPNEPWVICSVS 394 D + +W +D +D E + + GH + SDF + +CS S Sbjct: 172 SYDDTVRIW-----------KDYDD-DWECVAVLNGHEGTVWSSDFD-KTEGVFRLCSGS 218 Query: 395 EDNIMQVWQMAENIYNDEDPE 415 +D+ ++VW+ + +DED + Sbjct: 219 DDSTVRVWKY---MGDDEDDQ 236 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 59/292 (20%), Positives = 116/292 (39%), Gaps = 69/292 (23%) Query: 115 IEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR 174 I++ + H+ + + P + A S D V + K S D + E + + Sbjct: 49 IDVLDETAHKKAIRSVAWRPHTSLLAA---GSFDSTVSIWAKEES-ADRTFEMDLLAIIE 104 Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH+ E G++W+ N +L + S D ++ +W+ + G+ + ++ H+ V+ V Sbjct: 105 GHENEVKGVAWS-NDGYYLATCSRDKSVWIWE---TDESGEEYECISVLQEHSQDVKHVI 160 Query: 235 WH----LLHESLF------------------------GSV-----------------ADD 249 WH LL S + G+V +DD Sbjct: 161 WHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDD 220 Query: 250 QKLMIWDTRSNNTSKPSHSV------DAHTAEVNCLS--FNPYSEFILATGSADKTVALW 301 + +W ++ V D H +V ++ FN ++A+ AD +A++ Sbjct: 221 STVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG----LIASVGADGVLAVY 276 Query: 302 DLRNLKLKLHSFESHKDEIFQ---VQWSPHN-ETILASSGTDRRLNVWDLSK 349 + + + K+ + + +++ V+W N +TILA+ G D +N W L K Sbjct: 277 EEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 >4L9O-A nrPDB Length = 349 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 113/259 (43%), Gaps = 31/259 (11%) Query: 117 IEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 +E I HEG V + + P+ I+A+ + VL++ + +G N Sbjct: 106 VETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK--------EDNGVWNKVAEHSV 157 Query: 176 HQKEGYGLSWNPNLSGH-LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 HQ +SW P+ G LL AS D I + + K+G ++ + GH V S Sbjct: 158 HQASVNSVSWAPHEYGPVLLCASSDGKISIVEF----KDGGALEP-IVIQGHAIGVNAAS 212 Query: 235 WHLL----HESLFGSVADDQKLMIWDTRSNNTSKP---SHSVDAHTAEVNCLSFNP--YS 285 W + + F S D + IW R ++ +K + H+ V ++++P S Sbjct: 213 WAPISLPDNTRRFVSGGCDNLVKIW--RYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLS 270 Query: 286 EFILATGSADKTVALW--DLRNLKLKLHSFESHK--DEIFQVQWSPHNETILASSGTDRR 341 + +AT S D+TV +W D ++ K + K D ++ WS +LA SG D + Sbjct: 271 KSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSG-NVLAISGGDNK 329 Query: 342 LNVWDLSKIGEEQSPEDAE 360 + +W + G+ +S + + Sbjct: 330 VTLWKENIQGKWESAGEVD 348 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 16/117 (13%) Query: 289 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 346 LAT S+DKT+ ++++ +L + H+ ++QV W+ P ILAS D ++ +W Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQV 401 ++G + H H A ++ SW P+E P ++C+ S+ I V Sbjct: 144 ------------EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIV 188 >6F1U-h nrPDB Length = 612 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 109/267 (40%), Gaps = 29/267 (10%) Query: 124 EGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL 183 + V A + +P ++ T S ++++D + P + P L H Y + Sbjct: 306 QSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTP---VQRTP-LSAAAHTHPVYCV 361 Query: 184 SWNPNLSGH-LLSASDDHTICLWDISA----------VPKEGKVVDAKTIFTGHTAVVED 232 + + H L+S S D IC W + V K+ K V T + V D Sbjct: 362 NVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAV----AVTSMSFPVGD 417 Query: 233 VSWHLLHE---SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 V+ ++ S++ + K I + + P + H A V + F+ + Sbjct: 418 VNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQG-PITGIHCHAA-VGAVDFS----HLF 471 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 T S D TV LW +N K L+SFE + ++ V WSP + + A RL++W+L+ Sbjct: 472 VTSSFDWTVKLWSTKNNK-PLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNN 530 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAK 376 E + + +G P L + H+ + Sbjct: 531 DTEVPTASISVEGNPALNRVRWTHSGR 557 >3EI3-B nrPDB Length = 383 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 4/77 (5%) Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES---HKDEIFQVQWSPH 328 H A+V FNP ++++AT S D TV LWDLRN+K K +S+ + H+ + ++P Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDK-NSYIAEMPHEKPVNAAYFNPT 261 Query: 329 NETILASSGTDRRLNVW 345 + T L ++ + V+ Sbjct: 262 DSTKLLTTDQRNEIRVY 278 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 11/40 (27%), Positives = 24/40 (60%) Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 HK ++ +++P + ++A+S D + +WDL I ++ S Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNS 242 >6J6H-n nrPDB Length = 455 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 81/175 (46%), Gaps = 16/175 (9%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + L + P +LS +DHTI +WD + F GH ++ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY------HDYECLRDFQGHNKPIKALR 213 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + +S F S + D+ + IWDT + H +++ A+V NP+ EFI+ G + Sbjct: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPH-EFIV--GLS 268 Query: 295 DKTVALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 + + +D R N L + +++ H I +++ P ++SS D+ + +W+ Sbjct: 269 NSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSS-EDKTVRIWE 321 >4G56-B nrPDB Length = 357 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 22/174 (12%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 H E ++ P LS +D I LWD PK +D F + V+ Sbjct: 179 AHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK-PKPATRID----FCASDTIPTSVT 233 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 WH + F + + + + ++ ++++ S H+ + L+++ +S LA+ S Sbjct: 234 WHPEKDDTFACGDETGNVSLVNIKNPDSAQTSA---VHSQNITGLAYSYHSSPFLASISE 290 Query: 295 DKTVALWD------LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 D TVA+ D R+L SH+D + V WSP + + + G D ++ Sbjct: 291 DCTVAVLDADFSEVFRDL--------SHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 26/243 (10%) Query: 162 DPSGECNPDLRLRGHQKEG--YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 DP G N L G Q E ++W +L ASD + LW+I + KE +V+ Sbjct: 77 DPEGAPNESLCTAGVQTEAGVTDVAWVSEKG--ILVASDSGAVELWEI--LEKESLLVNK 132 Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279 + H +V+ +S + S D + +WD K S +AH++EVNC+ Sbjct: 133 FAKYE-HDDIVKTLS-VFSDGTQAVSGGKDFSVKVWDLSQKAVLK---SYNAHSSEVNCV 187 Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEI-FQVQWSPHNETILASSGT 338 + P + I + D + LWD R K D I V W P + A Sbjct: 188 AACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDE 247 Query: 339 DRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 +++ ++ ++P+ A+ H+ I+ +++ + + S+SED Sbjct: 248 TGNVSLVNI------KNPDSAQTSAV--------HSQNITGLAYSYHSSPFLASISEDCT 293 Query: 399 MQV 401 + V Sbjct: 294 VAV 296 >5UZ7-B nrPDB Length = 351 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 71/159 (44%), Gaps = 14/159 (8%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 ++++S D T LWDI + T FTGHT V +S LF S A D Sbjct: 167 QIVTSSGDTTCALWDI-------ETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDAS 218 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKL 310 +WD R + + H +++N + F P ATGS D T L+DLR + +L Sbjct: 219 AKLWDVREGMCRQ---TFTGHESDINAICFFPNGN-AFATGSDDATCRLFDLRADQELMT 274 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 +S ++ I V +S +LA D NVWD K Sbjct: 275 YSHDNIICGITSVSFSKSGRLLLAGY-DDFNCNVWDALK 312 >5CXC-A nrPDB Length = 510 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 57/113 (50%), Gaps = 5/113 (4%) Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI 254 SAS DHT+ D++ G+VV T+ T + ++ L + + + + Sbjct: 330 SASQDHTVRTLDLTT----GQVVSTLTL-THPLLSLSALTRAGTTSPLLAAGTSARHITM 384 Query: 255 WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 D R+++ + ++ H +V LS +P +E+ L +GS D T +WDLR+++ Sbjct: 385 VDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVR 437 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 57/276 (20%), Positives = 107/276 (38%), Gaps = 38/276 (13%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H + A+++ + +A+ V V+ YT+ +GE P L L GH Sbjct: 190 GHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTE---SDHFTGELKPTLELYGHTGSVD 244 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISA---------------VPKEGKVVDAKT----- 221 L + + S H+L+AS D I W S V K K + + Sbjct: 245 WLDVDGH-SKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRG 303 Query: 222 ---IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN---NTSKPSHSVDAHTAE 275 +++ HTA + ++ S + D + D + +T +H + + +A Sbjct: 304 PLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSAL 363 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETIL 333 + +P +LA G++ + + + D R + + + H +++ + SP NE L Sbjct: 364 TRAGTTSP----LLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSL 419 Query: 334 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 S D VWDL + E + G E +++ Sbjct: 420 VSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYV 455 >4YCZ-A nrPDB Length = 876 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 57/114 (50%), Gaps = 16/114 (14%) Query: 289 LATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWS-PHNETILASSGTDRRLNVWD 346 LAT S+D+T+ ++++ +L + + H ++ V W+ P ILAS+G D ++ +W Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR 92 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI--CSVSEDNI 398 +G + +F H A ++ SW+P+E + C+ S+ N+ Sbjct: 93 ------------ELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 68/164 (41%), Gaps = 18/164 (10%) Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF-N 282 +GH ++ D L + + D+ + I++ T + + ++ H V C+S+ + Sbjct: 15 SGHDDMIHDAVLDYYGRRL-ATCSSDRTIKIFEI-EGETQRLTETLKGHDGAVWCVSWAH 72 Query: 283 PYSEFILATGSADKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNE-TILASSGTDR 340 P ILA+ D V +W +L ++ F HK + V WSPH +LA + +D Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384 ++V + E S I H ++ SW P Sbjct: 133 NVSVLEFRDNSWEHS-------------IFHAHGLGVNSVSWAP 163 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 47/196 (23%), Positives = 82/196 (41%), Gaps = 36/196 (18%) Query: 183 LSWNPNLSGHLLS-ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW------ 235 +SW+P+ +G LL+ AS D + + + E +IF H V VSW Sbjct: 114 VSWSPHEAGCLLACASSDGNVSVLEFRDNSWE------HSIFHAHGLGVNSVSWAPATSP 167 Query: 236 ----------HLLHESLFGSVADDQKLMIW--DTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 F + D L IW D +N + HT V ++++P Sbjct: 168 GSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSP 227 Query: 284 --YSEFILATGSADKTVALW-----DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 + +A+ S D+TV +W + K+ +F++ +++V WS +LA+S Sbjct: 228 TVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDA---AVWRVSWSLSG-NVLAAS 283 Query: 337 GTDRRLNVWDLSKIGE 352 G D ++ +W + GE Sbjct: 284 GGDNKVTLWKENLKGE 299 >4E5Z-B nrPDB Length = 436 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 37/70 (52%), Gaps = 2/70 (2%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES--HKDEIFQVQW 325 ++ H +V ++ NP ++ LAT S D+TV +WDLR ++ K S H+ + + Sbjct: 245 NLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACF 304 Query: 326 SPHNETILAS 335 SP +L + Sbjct: 305 SPDGARLLTT 314 Score = 29.3 bits (64), Expect = 3.0, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 10/56 (17%) Query: 300 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 LW+LR HK ++ V +P + LA++ D+ + +WDL ++ + S Sbjct: 243 LWNLR----------MHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS 288 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 22/38 (57%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAV 210 LR H+K+ ++ NP L +AS D T+ +WD+ V Sbjct: 246 LRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 283 >6E29-D nrPDB Length = 345 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 11/102 (10%) Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 ++DD L + NT + HS C+ FN +F LA+G D TV +WDL Sbjct: 6 LSDDYLLQDYPENITNTIRSGHS--------TCVRFNRKGDF-LASGRVDGTVVIWDLET 56 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + + H I + WS +L S+ ++ +WDL Sbjct: 57 MGVA-RKLRGHSKNITSLSWSRCGRYLL-SACQGWKVILWDL 96 Score = 32.0 bits (71), Expect = 0.48, Method: Compositional matrix adjust. Identities = 16/72 (22%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 N ++F+ E++ A+ + + +W+ R + E K+E ++W PH + A Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWE-RGHGSLVRMLEGPKEEQGVIEWHPHRALLAACG 333 Query: 337 GTDRRLNVWDLS 348 R+N+W ++ Sbjct: 334 LETGRINIWSVT 345 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI 207 +LRGH K LSW+ +LLSA + LWD+ Sbjct: 62 KLRGHSKNITSLSWS-RCGRYLLSACQGWKVILWDL 96 >3JAP-g nrPDB Length = 326 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/247 (21%), Positives = 109/247 (44%), Gaps = 33/247 (13%) Query: 168 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 227 N + R GH + ++ + N S ++SAS D TI +W+ V D + GHT Sbjct: 99 NSEARFVGHTGDVLSVAIDAN-SSKIISASRDKTIRVWN--------TVGDCAYVLLGHT 149 Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWD------TRSNNTSKPSHSVDA----HTAEVN 277 V V + ++L DD ++ RS + ++ S+ ++A H +N Sbjct: 150 DWVTKV--RVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYIN 207 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 + +P + G D + +W+L++ K +F++ KDE+F + +SP + A++ Sbjct: 208 VVQPSPDGSLAASAGK-DGQIYVWNLKH-KSAFMNFDA-KDEVFALAFSPSRFWLTAATA 264 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 + + ++DL ++ ++ PE +W+ + + + DN Sbjct: 265 SG--IKIYDL------ENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYT-DN 315 Query: 398 IMQVWQM 404 +++VWQ+ Sbjct: 316 VIRVWQV 322 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 73/166 (43%), Gaps = 23/166 (13%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 + +SAS D T+ LW+++ E + F GHT V V+ + S S + D+ Sbjct: 80 YAVSASWDKTLRLWNLATGNSEAR-------FVGHTGDVLSVAID-ANSSKIISASRDKT 131 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---------EFILATGSADKTVALWD 302 + +W+T ++ + HT V + P + + DK V W Sbjct: 132 IRVWNT----VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 303 LRNLKLKLHS-FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 L ++ + F H + I VQ SP + ++ AS+G D ++ VW+L Sbjct: 188 LNEDSYRIEADFIGHNNYINVVQPSP-DGSLAASAGKDGQIYVWNL 232 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 61/139 (43%), Gaps = 20/139 (14%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL----RNLKLKLHSFESHKDEIFQV 323 +++ H V LS + +L +GS DKT+ W L + + + S++ H + V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 S +++S D+ L +W+L+ G E F+ GHT + + + Sbjct: 73 VVSADGNYAVSAS-WDKTLRLWNLAT------------GNSEARFV--GHTGDVLSVAID 117 Query: 384 PNEPWVICSVSEDNIMQVW 402 N +I S S D ++VW Sbjct: 118 ANSSKII-SASRDKTIRVW 135 >5WLC-LJ nrPDB Length = 513 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 63/161 (39%), Gaps = 20/161 (12%) Query: 197 SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV---SWHLLHESLFGSVADDQKLM 253 SD +C D + + + +TI A +H + + +DD+ Sbjct: 91 SDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTR 150 Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313 +WD +N +P + T V LSF P + ++ATGS D + L+D R+ Sbjct: 151 LWDI--SNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRS-------- 200 Query: 314 ESHKDEIFQVQWSPHNETILASSGTD------RRLNVWDLS 348 S I+ + E ++A S T VWDL+ Sbjct: 201 -SGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLT 240 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 26/115 (22%), Positives = 50/115 (43%), Gaps = 13/115 (11%) Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 +L G A V+++D N + L S + ++ + ILA++ DR +WD+ Sbjct: 95 LLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDI 154 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 S E P+L G T + S+ P P ++ + S D +++++ Sbjct: 155 SNAYE-----------PQLELT--GATDYVRTLSFIPAAPHLVATGSYDGLIRLY 196 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 73/159 (45%), Gaps = 18/159 (11%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 L +ASDD LWDIS + + TG T V +S+ L + + D + Sbjct: 140 LATASDDRVTRLWDIS------NAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLI 193 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 ++DTRS+ S P +S++ N ++ +P I++ G + V WDL + K KL+ Sbjct: 194 RLYDTRSSG-STPIYSLNHDQPVENVIAVSPTQ--IVSCGGNNFKV--WDLTSNK-KLYE 247 Query: 313 FESHKDEIFQVQW-----SPHNETILASSGTDRRLNVWD 346 + + + + SP ++ASS D + V+D Sbjct: 248 RGNFNKAVTCLDYVENFDSPMQSALIASS-LDGHVKVFD 285 >6BX3-B nrPDB Length = 412 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 320 K +H+++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 17 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 74 Query: 321 FQVQWSPHNETILASSGTDRRLNVWDLSK 349 + WSP +L SS D + +WDLSK Sbjct: 75 TSIAWSPDGRLLLTSS-RDWSIKLWDLSK 102 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 1/49 (2%) Query: 167 CNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 215 C P L H + ++W+P+ LL++S D +I LWD+S K K Sbjct: 61 CVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLK 108 >6EOJ-D nrPDB Length = 470 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 10/118 (8%) Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 244 + P L++ S D + ++DI KE V +T + + WH ++ES+F Sbjct: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-------LEWHPINESMFT 321 Query: 245 SVADDQKLMIWDTRSNNTSKPSHSVD-AHTAEVNCLSFNPYSEFILATGSADKTVALW 301 D L +D N ++P ++ AH + LS+NP I AT + D+T+ W Sbjct: 322 LACYDGSLKHFDLL-QNLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFW 377 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 29/134 (21%), Positives = 62/134 (46%), Gaps = 18/134 (13%) Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 328 + AH + V + ++ S+++++ G AD + +W N + +H + I + +S Sbjct: 131 MQAHDSAVTTMKYSHDSDWMIS-GDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFS-S 187 Query: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388 N++ + D L +W+ S +E+ + GH + W+P E Sbjct: 188 NDSKFVTCSDDNILKIWNFSNGKQER--------------VLSGHHWDVKSCDWHP-EMG 232 Query: 389 VICSVSEDNIMQVW 402 +I S S+DN++++W Sbjct: 233 LIASASKDNLVKLW 246 >5FVM-C nrPDB Length = 303 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 77/176 (43%), Gaps = 24/176 (13%) Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 + S D + W+ + S+ D+ +VN L +++ A G V L+ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADS---QVNRLEITSDKKYLAAAGHLH--VRLY 58 Query: 302 DLR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 D+R N + SFE HK + + + N +++SS D + VWD+ +SP Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSS-EDGTIKVWDV------RSPSVQR 111 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN-IYNDEDPE 415 + H A +++ + +PN+ +I S +D +++W + EN N PE Sbjct: 112 NYK---------HNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPE 157 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 80/205 (39%), Gaps = 63/205 (30%) Query: 193 LLSASDDHTICLWDIS--AVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQ 250 ++S+S+D TI +WD+ +V + K H A V +V+ H L S D Sbjct: 90 MVSSSEDGTIKVWDVRSPSVQRNYK----------HNAPVNEVAIHPNQGELI-SCDQDG 138 Query: 251 KLMIWDTRSNNTS-----------------------------------KPSHSVDAHTAE 275 + IWD N + + H DA T E Sbjct: 139 NIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLE 198 Query: 276 VNCLSFNPYSEFI-----------LATGSADKTVALWDLR-NLKLKLHSFESHKDEIFQV 323 F ++++I LAT SAD T +W++ N +L+ + + H+ ++ Sbjct: 199 -PVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLET-TLDGHQRWVWDC 256 Query: 324 QWSPHNETILASSGTDRRLNVWDLS 348 +S + L ++ +D + +WDLS Sbjct: 257 AFSA-DSAYLVTACSDHYVRLWDLS 280 >6EMK-B nrPDB Length = 303 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 79/172 (45%), Gaps = 16/172 (9%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 248 +S L+SA DHTI W+ V ++TI + V + ++ + A Sbjct: 1 MSVILVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNR---LEITNDKKLLATAG 51 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308 Q + ++D R+ N P S + H V +SF + +++ T S D T+ +WD+R+ + Sbjct: 52 HQNVRLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSI 109 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL--SKIGEEQSPED 358 + H + +V P N+ L S D + +WDL ++ + +PED Sbjct: 110 PRN--YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 25/36 (69%), Gaps = 1/36 (2%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDIS 208 L GHQ+ + +++ + S +L++AS DH + LWD+S Sbjct: 246 LDGHQRWVWDCAFSAD-SAYLVTASSDHYVRLWDLS 280 >6QDV-o nrPDB Length = 513 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 K H HT V+ + P S +L + S D + LW++ + L +F H + + Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 324 QWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPEDAEDGPPE---LLFIHGGHT 374 ++ L S+ DR L +WD +S+ + P + P E LF+ G Sbjct: 273 CFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 331 Query: 375 AKI 377 KI Sbjct: 332 KKI 334 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 32/160 (20%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +S SDD ++ +W+ +P + K + ++ + + L +S+ D + Sbjct: 366 RFVSTSDDKSLRVWEWD-IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM------DNQ 418 Query: 252 LMIWDTRSN---NTSK--PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 ++I+ ++ N K H V + +V+ F+P +++ +G + + +WD + Sbjct: 419 ILIFGAQNRFRLNKKKIFKGHMVAGYACQVD---FSPDMSYVI-SGDGNGKLNIWDWKTT 474 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 KL F++H W PH + + + G D + +WD Sbjct: 475 KL-YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 35.8 bits (81), Expect = 0.037, Method: Compositional matrix adjust. Identities = 45/235 (19%), Positives = 84/235 (35%), Gaps = 58/235 (24%) Query: 208 SAVPKEGKVVDAKTI--FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNT--- 262 S +P E + K I ++GHT V V L L S + D K+ +W+ Sbjct: 201 STMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLR 260 Query: 263 -----SKPSHSVDAHTAEVN-------------------------------CLSFNP--Y 284 SK + +TA C+ FNP Sbjct: 261 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDED 320 Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 + + G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L V Sbjct: 321 KQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTS-DDKSLRV 378 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 399 W+ D P + +I + + +PN W+ C ++ I+ Sbjct: 379 WEW-------------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 420 >5WLC-LO nrPDB Length = 923 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 97/234 (41%), Gaps = 52/234 (22%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA------------------VPK 212 L+ +GH L+++P+ S +++AS+D I +WDI++ K Sbjct: 339 LKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK 397 Query: 213 EGKVVDAKTI-----------------FTGHTAVVEDVSWHLLHESLFGSVA-----DDQ 250 G+V+ + ++ FTG E + ++ L G V D+ Sbjct: 398 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTG----TERIQFNCLAVDPSGEVVCAGSLDNF 453 Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310 + +W S T + ++ H V+CLSF+ + +LA+ S DKT+ +W + ++ Sbjct: 454 DIHVW---SVQTGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIWSIFGRSQQV 509 Query: 311 HSFESHKDEIFQVQWSPHNETILASS--GTDRRLNVWDLSKIGEEQSPEDAEDG 362 E + D + + P + + S+ G N+ D ++G +D G Sbjct: 510 EPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 562 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 11/104 (10%) Query: 303 LRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 L N K + LH F + K++ V++SP +SG R L +W + + D + Sbjct: 81 LVNFKARNVLHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPDVNK-----DRQ 132 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 P +H GH I+ +W+ + +++ + S+D ++W + Sbjct: 133 FAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSV 175 >5YZG-W nrPDB Length = 579 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 10/123 (8%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 K H HT V+ + P S +L + S D + LW++ + L +F H + + Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 324 QWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPEDAEDGPPE---LLFIHGGHT 374 ++ L S+ DR L +WD +S+ + P + P E LF+ G Sbjct: 339 CFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 397 Query: 375 AKI 377 KI Sbjct: 398 KKI 400 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 32/160 (20%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +S SDD ++ +W+ +P + K + ++ + + L +S+ D + Sbjct: 432 RFVSTSDDKSLRVWEWD-IPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSM------DNQ 484 Query: 252 LMIWDTRSN---NTSK--PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 ++I+ ++ N K H V + +V+ F+P +++ +G + + +WD + Sbjct: 485 ILIFGAQNRFRLNKKKIFKGHMVAGYACQVD---FSPDMSYVI-SGDGNGKLNIWDWKTT 540 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 KL F++H W PH + + + G D + +WD Sbjct: 541 KL-YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 35.8 bits (81), Expect = 0.035, Method: Compositional matrix adjust. Identities = 45/235 (19%), Positives = 84/235 (35%), Gaps = 58/235 (24%) Query: 208 SAVPKEGKVVDAKTI--FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNT--- 262 S +P E + K I ++GHT V V L L S + D K+ +W+ Sbjct: 267 STMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLR 326 Query: 263 -----SKPSHSVDAHTAEVN-------------------------------CLSFNP--Y 284 SK + +TA C+ FNP Sbjct: 327 TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDED 386 Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 + + G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L V Sbjct: 387 KQNLFVAGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTS-DDKSLRV 444 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 399 W+ D P + +I + + +PN W+ C ++ I+ Sbjct: 445 WEW-------------DIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQIL 486 >5K1B-B nrPDB Length = 677 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 74/164 (45%), Gaps = 19/164 (11%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 L+SAS D T+ +W+ K T+ T H V+ +++ E L S D+++ Sbjct: 90 LISASSDTTVKVWNAH------KGFCMSTLRT-HKDYVKALAYAKDKE-LVASAGLDRQI 141 Query: 253 MIWD-------TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 +WD T SNNT S S+ + + L+ N I+ +GS +K + +WD R Sbjct: 142 FLWDVNTLTALTASNNTVTTS-SLSGNKDSIYSLAMNQLGT-IIVSGSTEKVLRVWDPRT 199 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 KL + H D + + + L+ S +D + +W L + Sbjct: 200 CA-KLMKLKGHTDNVKALLLNRDGTQCLSGS-SDGTIRLWSLGQ 241 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/199 (21%), Positives = 78/199 (39%), Gaps = 19/199 (9%) Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 L +P L+ L +A D I +W ++ ++ + + HT V D+ ++ Sbjct: 35 ALQLDPALN-RLFTAGRDSIIRIWSVNQHKQDPYIASME----HHTDWVNDIVLCCNGKT 89 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L S + D + +W+ ++ H V L++ E + + G D+ + LW Sbjct: 90 LI-SASSDTTVKVWNAHKGFCMS---TLRTHKDYVKALAYAKDKELVASAG-LDRQIFLW 144 Query: 302 DLRNLK--------LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 D+ L + S +KD I+ + + TI+ S T++ L VWD + Sbjct: 145 DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-TIIVSGSTEKVLRVWDPRTCAKL 203 Query: 354 QSPEDAEDGPPELLFIHGG 372 + D LL G Sbjct: 204 MKLKGHTDNVKALLLNRDG 222 >5I2T-A nrPDB Length = 742 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 97/234 (41%), Gaps = 52/234 (22%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA------------------VPK 212 L+ +GH L+++P+ S +++AS+D I +WDI++ K Sbjct: 364 LKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAK 422 Query: 213 EGKVVDAKTI-----------------FTGHTAVVEDVSWHLLHESLFGSVA-----DDQ 250 G+V+ + ++ FTG E + ++ L G V D+ Sbjct: 423 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTG----TERIQFNCLAVDPSGEVVCAGSLDNF 478 Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310 + +W S T + ++ H V+CLSF+ + +LA+ S DKT+ +W + ++ Sbjct: 479 DIHVW---SVQTGQLLDALSGHEGPVSCLSFSQENS-VLASASWDKTIRIWSIFGRSQQV 534 Query: 311 HSFESHKDEIFQVQWSPHNETILASS--GTDRRLNVWDLSKIGEEQSPEDAEDG 362 E + D + + P + + S+ G N+ D ++G +D G Sbjct: 535 EPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 587 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 11/104 (10%) Query: 303 LRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 L N K + LH F + K++ V++SP +SG R L +W + + D + Sbjct: 106 LVNFKARNVLHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPDVNK-----DRQ 157 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 P +H GH I+ +W+ + +++ + S+D ++W + Sbjct: 158 FAPFVRHRVHAGHFQDITSLTWSQDSRFIL-TTSKDLSAKIWSV 200 >6Q8F-A nrPDB Length = 514 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 5/106 (4%) Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 + + A D K+ +W +S + AH+ V CLSF+ S IL + S D+T+ + Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFER--AHSKGVTCLSFSKDSSQIL-SASFDQTIRIH 335 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 L++ K L F H + + ++ I+++S +D + +W++ Sbjct: 336 GLKSGK-TLKEFRGHSSFVNEATFTQDGHYIISAS-SDGTVKIWNM 379 Score = 31.6 bits (70), Expect = 0.70, Method: Compositional matrix adjust. Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 19/130 (14%) Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE-SHKDEIFQVQWSPHNETILA 334 V C+ F+ +E +LATG+ D + +W +++ + L FE +H + + +S + IL+ Sbjct: 268 VLCMCFSRDTE-MLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSKDSSQILS 325 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 +S D+ + + L K G+ L GH++ +++ ++ + ++I S S Sbjct: 326 AS-FDQTIRIHGL-KSGKT-------------LKEFRGHSSFVNEATFTQDGHYII-SAS 369 Query: 395 EDNIMQVWQM 404 D +++W M Sbjct: 370 SDGTVKIWNM 379 >6CB1-s nrPDB Length = 569 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%) Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 LA +LN+ S I E SP+D P I+ GH K+ S +P+ W + + Sbjct: 158 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 216 Query: 393 VSEDNIMQVWQM 404 S+D ++VW++ Sbjct: 217 GSDDGTVRVWEI 228 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 H +V LS +P S LATGS D TV +W++ Sbjct: 197 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEI 228 >5LTD-A nrPDB Length = 525 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 55/106 (51%), Gaps = 10/106 (9%) Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 ++I+D + T +P+ ++AH + ++ + +LAT S T+ +KL+ Sbjct: 204 VIIFDAK---TLQPTSVIEAHRTSLAAIALSK-DGLLLATASDKGTIIRVFSVATGIKLY 259 Query: 312 SFE--SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 F ++ +I+ + +SP N ++ASS T+ + ++GEE++ Sbjct: 260 QFRRGTYPTKIYSLAFSPDNRFVIASSATE----TVHIFRLGEEEA 301 >6GMH-W nrPDB Length = 305 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 9/100 (9%) Query: 289 LATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + TGS D V +W R+ +L L S E H+ + V S H I ASS D + +WDL Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS-HTLPIAASSSLDAHIRLWDL 93 Query: 348 SKIGEEQS----PEDA---EDGPPELLFIHGGHTAKISDF 380 + +S P DA P G H K++ F Sbjct: 94 ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 94/183 (51%), Gaps = 17/183 (9%) Query: 164 SGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIF 223 SG+ L RG K ++++P+ +L S + D I ++DI+ GK++ Sbjct: 137 SGKKEYSLDTRG--KFILSIAYSPD-GKYLASGAIDGIINIFDIAT----GKLLHT---L 186 Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 GH + +++ L + +DD + I+D + N + ++ H + V ++F P Sbjct: 187 EGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAG---TLSGHASWVLNVAFCP 242 Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 + + S+DK+V +WD+ + +H+F H+D+++ V+++ + I+ S G D+ ++ Sbjct: 243 -DDTHFVSSSSDKSVKVWDV-GTRTCVHTFFDHQDQVWGVKYNGNGSKIV-SVGDDQEIH 299 Query: 344 VWD 346 ++D Sbjct: 300 IYD 302 >6C0F-s nrPDB Length = 807 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%) Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 LA +LN+ S I E SP+D P I+ GH K+ S +P+ W + + Sbjct: 396 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 454 Query: 393 VSEDNIMQVWQM 404 S+D ++VW++ Sbjct: 455 GSDDGTVRVWEI 466 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 H +V LS +P S LATGS D TV +W++ Sbjct: 435 GHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEI 466 >5BJS-A nrPDB Length = 605 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 30/133 (22%), Positives = 61/133 (45%), Gaps = 13/133 (9%) Query: 276 VNCLSFNPYS-EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334 +C S +P + + +L + V ++++ KL + H I + SP N I+A Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKL-YRTLVGHGGGINDLATSPANPYIIA 195 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG-GHTAKISDFSWNPNEPWVICSV 393 S+ D + +W L+ E+Q P + + G GH+ + +++ N +V+ S Sbjct: 196 SASDDTTIRIWSLAPEHEKQ---------PCVCILGGEGHSYDLLSVAFHDNGRYVL-SA 245 Query: 394 SEDNIMQVWQMAE 406 D ++ +W + E Sbjct: 246 GHDQVINLWALPE 258 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 7/94 (7%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT-KHPSKPDPSGECNPDLRLRGHQKE 179 + H G +N P NP IIA+ + + + ++ +H +P C L GH + Sbjct: 175 VGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQP-----CVCILGGEGHSYD 229 Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKE 213 ++++ N ++LSA D I LW + P E Sbjct: 230 LLSVAFHDN-GRYVLSAGHDQVINLWALPEFPNE 262 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 28/139 (20%), Positives = 61/139 (43%), Gaps = 18/139 (12%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 L A ++ + +++++ EGK+ GH + D++ + + S +DD + Sbjct: 151 LCIAGNEGNVKVYNVT----EGKLY---RTLVGHGGGINDLATSPANPYIIASASDDTTI 203 Query: 253 MIWDTRSNNTSKPSHSV---DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 IW + +P + + H+ ++ ++F+ ++L+ G D+ + LW Sbjct: 204 RIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGH-DQVINLW-------A 255 Query: 310 LHSFESHKDEIFQVQWSPH 328 L F + EI V + PH Sbjct: 256 LPEFPNEHMEIPIVIYYPH 274 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 14/144 (9%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH L+ +P + SASDD TI +W + A E + GH+ + Sbjct: 174 LVGHGGGINDLATSPANPYIIASASDDTTIRIWSL-APEHEKQPCVCILGGEGHSYDLLS 232 Query: 233 VSWHLLHESLFGSVADDQKLMIW---DTRSNNTSKP-------SHSVDAHTAEVNCLSFN 282 V++H + S DQ + +W + + + P S + H V+C++F Sbjct: 233 VAFHDNGRYVL-SAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF- 290 Query: 283 PYSEFILATGSADKTVALWDLRNL 306 Y + IL+ + T+ LW + Sbjct: 291 -YGDLILSRACHEDTIVLWRIEGF 313 >6EM1-m nrPDB Length = 807 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%) Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 LA +LN+ S I E SP+D P I+ GH K+ S +P+ W + + Sbjct: 396 LAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LAT 454 Query: 393 VSEDNIMQVWQM 404 S+D ++VW++ Sbjct: 455 GSDDGTVRVWEI 466 >4XFV-A nrPDB Length = 792 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 25/227 (11%) Query: 201 TICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 260 TI LWD P E GH A V V + + S ++D + IW Sbjct: 41 TIALWD----PIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDY 95 Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKL-HSFESHK 317 + + ++ ++ + LS P +++ G AD T+++W +++N + L H F K Sbjct: 96 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 152 Query: 318 DEIFQVQWS----PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 + + S + +LA GT+ +NV+ S I + E EL GH Sbjct: 153 GFFYPLCLSLSKVEEKKYLLAIGGTN--VNVFIASFILSDSGIEKCR-VVAEL----EGH 205 Query: 374 TAKISDFSWNPNEP---WVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 + ++ E +++CS S+D +++W++ N D+ E S Sbjct: 206 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 >3JZG-A nrPDB Length = 402 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 19/86 (22%), Positives = 42/86 (48%), Gaps = 1/86 (1%) Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 + GH + ++ +H +L SV+ D L +W+ +++ V+ H EV ++ Sbjct: 147 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 206 Query: 283 PYSEFILATGSADKTVALWDLRNLKL 308 E I++ G D ++ LW + + ++ Sbjct: 207 LLGEKIMSCG-MDHSLKLWRINSKRM 231 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 10/33 (30%), Positives = 23/33 (69%) Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 GH I++ ++P +P ++ SVS+D+ +++W + Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 181 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 80/212 (37%), Gaps = 47/212 (22%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH L ++P LLS S DH + LW+I + +V GH V Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSAD 204 Query: 235 WHLLHESLFGSVADDQKLMIW---------------DTRSNNTSKPSHS----------V 269 + LL E + S D L +W D N T++P S Sbjct: 205 YDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 263 Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLK------LKLHSFESH 316 D H V+C+ + + IL+ S + + W D+ +K L F+ Sbjct: 264 DIHRNYVDCVRW--LGDLILSK-SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 320 Query: 317 KDEIFQVQWSPHN-ETILASSGTDRRLNVWDL 347 + +I+ +++S + +LA +L VWDL Sbjct: 321 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 352 >1PI6-A nrPDB Length = 615 Score = 35.8 bits (81), Expect = 0.037, Method: Compositional matrix adjust. Identities = 23/106 (21%), Positives = 50/106 (47%), Gaps = 13/106 (12%) Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP---------YSEFILATGSADKTVALW 301 K++++D +S + T+++N +S+ P E ++ATGS D + ++ Sbjct: 511 KILLYDLQSREVKTSRWAF--RTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 ++ + + +HKD + + W + L SSG D + W++ Sbjct: 569 SVKRPMKIIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWNV 612 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 47/228 (20%), Positives = 86/228 (37%), Gaps = 35/228 (15%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKV-VDAKTIFTGHTAVVEDVSWHLLHESL--FGSV 246 S +L S + + +W + + V V+ K+ F + D+SW L G Sbjct: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 Query: 247 ADDQKLMI-WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 D+ + I WD+ ++ V H+ +N T D +V + Sbjct: 138 RDNFGVFISWDSGNS-----LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPP 192 Query: 306 LKLKLHSFESHKDEIF--QVQWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPE 357 K HK F V++SP + + + G+DR+++ +D L I ++Q P Sbjct: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP- 251 Query: 358 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 + GG I SW ++ + +V D ++VW + Sbjct: 252 -----------VQGG----IFALSWLDSQKF--ATVGADATIRVWDVT 282 >5WLC-LW nrPDB Length = 554 Score = 35.0 bits (79), Expect = 0.063, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 28/40 (70%), Gaps = 2/40 (5%) Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 VN ++ + S + +AT AD+++ +WD+RN K +LHS ES Sbjct: 277 VNSIAID-RSGYYMATTGADRSMKIWDIRNFK-QLHSVES 314 >4OWR-A nrPDB Length = 339 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 52/124 (41%), Gaps = 18/124 (14%) Query: 187 PNLSGHLLSASD-DHTICLWDIS----AVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 P L G+ L A + + W++ +PK ++ HT V DV W Sbjct: 21 PTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM---------HTGPVLDVCWSDDGSK 71 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 +F + D M WD SN + + DA ++ + YS + TGS DKT+ W Sbjct: 72 VFTASCDKTAKM-WDLSSNQAIQIAQH-DAPVKTIHWIKAPNYS--CVMTGSWDKTLKFW 127 Query: 302 DLRN 305 D R+ Sbjct: 128 DTRS 131 Score = 27.7 bits (60), Expect = 9.7, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 9/70 (12%) Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVADDQK 251 + +AS D T +WD+S+ + H A V+ + W + S + + D+ Sbjct: 72 VFTASCDKTAKMWDLSS--------NQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKT 123 Query: 252 LMIWDTRSNN 261 L WDTRS+N Sbjct: 124 LKFWDTRSSN 133 >5MWJ-A nrPDB Length = 337 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 16/140 (11%) Query: 193 LLSASDDHTICLWDISA-VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 L+ + T+ +WD++A P+ + + A+ D + S D Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPD-------SKVCFSCCSDGN 164 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR-NLKLKL 310 + +WD + + HT +C+ + L TG D TV WDLR +L+ Sbjct: 165 IAVWDLHNQTLVR---QFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 311 HSFESHKDEIFQVQWSPHNE 330 H F S +IF + + P E Sbjct: 221 HDFTS---QIFSLGYCPTGE 237 >5A9Q-2 nrPDB Length = 326 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 22/162 (13%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKV--VDAKTIFTGHTAV-VEDVSW--HLLHESL-- 242 SG+L++ ++ + + + +E V + KT+ T H V V+ ++W +SL Sbjct: 32 SGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPP 91 Query: 243 ---FGSVADDQKLMIW--DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 297 F + A D K+ ++ D + N K ++ HT +N L F+P +A+ S D T Sbjct: 92 VIKFCTSAADMKIRLFTSDLQDKNEYK---VLEGHTDFINGLVFDPKEGQEIASVSDDHT 148 Query: 298 VALWDLRNLK---LKLH----SFESHKDEIFQVQWSPHNETI 332 +W+L ++ LH S H +E F++ + N TI Sbjct: 149 CRIWNLEGVQTAHFVLHSPGMSVCWHPEETFKLMVAEKNGTI 190 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 48/232 (20%), Positives = 88/232 (37%), Gaps = 31/232 (13%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH GL ++P + S SDDHT +W++ V V+ + + Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM---------S 170 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V WH E F + ++ I R + + + +V +S + + G Sbjct: 171 VCWH--PEETFKLMVAEKNGTI---RFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVG 225 Query: 293 S-ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL-NVWDLSKI 350 + A +WD+ + H D +WS +E + A++G ++ + + + + Sbjct: 226 AVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHL 285 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 G Q P L+ G A S SW+ P +C + D+ + W Sbjct: 286 GHPQ---------PILM----GSVAVGSGLSWHRTLP--LCVIGGDHKLLFW 322 >5N4A-A nrPDB Length = 771 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 56/248 (22%), Positives = 88/248 (35%), Gaps = 72/248 (29%) Query: 188 NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES------ 241 N+ L + SDD TI W++ P E KV FT D+ W+ + Sbjct: 23 NVWNELFTCSDDQTIHKWNMLGEP-EQKVSTLDAYFT-------DMHWYPVSSKKTQAGG 74 Query: 242 --LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PYSEFILATGSADKTV 298 +F D + I + T + S++ H C+S Y LAT D +V Sbjct: 75 TDVFAVACTDGSVKIL----SRTGRVEKSIEGHKGA--CISLRWSYDGTALATAGEDGSV 128 Query: 299 ALWDLRNLKL----------------------------------------KLHSFESHKD 318 +W RN L K +++++H Sbjct: 129 KIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDG 187 Query: 319 EIFQVQWSPHNETILASSGTDRRLNVWD-----LSKIGEEQSPEDAEDGPP--ELLFIHG 371 + +V WSP N I+ + G D + VWD L + G P + P EL + G Sbjct: 188 VVLKVDWSPINHLII-TGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFAVGG 246 Query: 372 GHTAKISD 379 +T ++ D Sbjct: 247 FNTLQLCD 254 >5TF2-A nrPDB Length = 407 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 3/59 (5%) Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 +LATG D V +W + +L+ K+ F++H+ EI + P + L + G D + +VW Sbjct: 186 LLATGGTDGYVRVWKVPSLE-KVLEFKAHEGEIEDLALGPDGK--LVTVGRDLKASVWQ 241 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 16/102 (15%) Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 +LR L+ + D + +V H+ T+LA+ GTD + VW + + Sbjct: 156 ELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL----------- 204 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 E + H +I D + P+ V +V D VWQ Sbjct: 205 ---EKVLEFKAHEGEIEDLALGPDGKLV--TVGRDLKASVWQ 241 >5A9Q-7 nrPDB Length = 360 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 32/142 (22%), Positives = 66/142 (46%), Gaps = 16/142 (11%) Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 A++I H ++ DVS+ H + + DQ + +WD + + S H+ V Sbjct: 4 ARSIAADHKDLIHDVSFDF-HGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 279 LSFNPYSEF--ILATGSADKTVALWD---------LRNLK--LKLHSFESHKDEIFQVQW 325 +++ + EF +LA+ S D+T A+W+ LR +K + + + V++ Sbjct: 63 VTW-AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKF 121 Query: 326 SP-HNETILASSGTDRRLNVWD 346 +P H +LA+ D + +++ Sbjct: 122 APKHMGLMLATCSADGIVRIYE 143 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 40/88 (45%), Gaps = 15/88 (17%) Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH---SFESHK 317 N + H + T +V + P + + ++G K ++H F++H Sbjct: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGP-----------TKFEIHIVAQFDNHN 278 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVW 345 ++++V W+ T+LASSG D + +W Sbjct: 279 SQVWRVSWNI-TGTVLASSGDDGCVRLW 305 >4U1E-I nrPDB Length = 347 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 43/83 (51%), Gaps = 5/83 (6%) Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 TGH + V ++ + LF S + D +W S N + ++D HT + + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLF-SCSKDSSASVW--YSLNGERLG-TLDGHTGTIWSIDVD 61 Query: 283 PYSEFILATGSADKTVALWDLRN 305 ++++ + TGSAD ++ LWD+ N Sbjct: 62 CFTKYCV-TGSADYSIKLWDVSN 83 >5WBU-D nrPDB Length = 328 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 3/110 (2%) Query: 245 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 + A Q + ++D SNN P S D + + F+ ++ TG D T +WDLR Sbjct: 60 AAAGYQHIRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLR 117 Query: 305 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 + L+ I V P N+ L +++WDL EQ Sbjct: 118 SRNLQCQRIFQVNAPINCVCLHP-NQAELIVGDQSGAIHIWDLKTDHNEQ 166 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 11/68 (16%) Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 +L G + D+ +I P + AHT F+P S +LAT SAD+T + Sbjct: 200 NLTGGIGDEVTQLI----------PKTKIPAHTRYALQCRFSPDST-LLATCSADQTCKI 248 Query: 301 WDLRNLKL 308 W N L Sbjct: 249 WRTSNFSL 256 >4MDV-A nrPDB Length = 375 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%), Gaps = 1/44 (2%) Query: 35 VMTHALEWPSLTAQWLPDVTRPEG-KDFSIHRLVLGTHTSDEQN 77 V+ +A++ PSL A+WL D G KD+++ RL++ D Q+ Sbjct: 283 VLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDLQD 326 >5CXB-B nrPDB Length = 369 Score = 31.6 bits (70), Expect = 0.60, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 10/118 (8%) Query: 289 LATGSADKTVALW---DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 L GS DK + LW DL N K F H + I V++ + A + D L ++ Sbjct: 257 LVVGSYDKRL-LWHDLDLSNRPYKTMRF--HTEAIRAVRFHKGGLPLFADASDDGSLQIF 313 Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGG-HTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 K+ +Q E+ P ++L H + + D W+P EPW + S D ++W Sbjct: 314 H-GKVPNDQL-ENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCV-SAGADGTARLW 368 Score = 31.2 bits (69), Expect = 0.96, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 5/72 (6%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE-IFQVQWSPHN 329 H V ++ +P + LATG D TV +W+L + ++ S + + DE + V+W P Sbjct: 19 GHEGRVRSVAIDP-TGVALATGGDDGTVRVWELLTGR-QVWSVKLNGDEAVNTVRWRPTK 76 Query: 330 ETIL--ASSGTD 339 +T + A++G D Sbjct: 77 DTFILAAAAGED 88 >4J0W-A nrPDB Length = 343 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 66/166 (39%), Gaps = 31/166 (18%) Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI 254 + D T+ +W I P+E ++V F GH ++ + HL++E S ADD + + Sbjct: 168 AGGRDGTVRVWKI---PEESQLV-----FYGHQGSIDCI--HLINEEHMVSGADDGSVAL 217 Query: 255 W---DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF----ILATGSADKTVALWD----L 303 W R + +H + + + ++ATGS V LW Sbjct: 218 WGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGF 277 Query: 304 RNLKL----KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 R L L L F I +++S + ++A G + RL W Sbjct: 278 RQLDLLCDIPLVGF------INSLKFSSSGDFLVAGVGQEHRLGRW 317 >5WYK-BB nrPDB Length = 943 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 40/172 (23%), Positives = 70/172 (40%), Gaps = 15/172 (8%) Query: 185 WNPNLSG---HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 W+ +L+ L++ S D T+ WD + V K F + D + L + Sbjct: 477 WSLDLTSDGKRLVTGSADKTVKFWDFKV--ENSLVPGTKNKFLPVLKLHHDTTLELTDDI 534 Query: 242 LFGSVADDQKLMIWDTRSN-------NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 L V+ D + + N ++ K S+ H V + + S+ I+ T SA Sbjct: 535 LCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMII-TSSA 593 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 DK + +W L + S +H+D I V++ P + + S D + WD Sbjct: 594 DKNIKIWGL-DFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCS-KDAVVKYWD 643 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 55/133 (41%), Gaps = 16/133 (12%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 L GH+ L ++ L+S S D I +WD+ K+ K TG Sbjct: 115 LNFNGHKAAITLLQFDGT-GTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQG 173 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 ED W + S + D + +WD +++ + +H AHT E C + ++ Sbjct: 174 ED--WLI-------STSKDGMIKLWDLKTHQCIE-THI--AHTGE--CWGLAVKDDLLIT 219 Query: 291 TGSADKTVALWDL 303 TG+ D V +W L Sbjct: 220 TGT-DSQVKIWKL 231 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 16/35 (45%), Positives = 19/35 (54%), Gaps = 1/35 (2%) Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 DAH A + L + L TGSADKTV WD + Sbjct: 470 DAHDAAIWSLDLTSDGKR-LVTGSADKTVKFWDFK 503 >3F3P-A nrPDB Length = 351 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 14/135 (10%) Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSF- 281 +GH +V DV + + + + DQ + ++ + ++ + S S AH + + + + Sbjct: 8 SGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 66 Query: 282 NPYSEFILATGSADKTVALWDL---------RNLKLKLHSFESHKDEIFQVQWSP-HNET 331 +P I+A+ S DKTV LW+ R KL + K ++ V+++P H Sbjct: 67 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWN-KLCTLNDSKGSLYSVKFAPAHLGL 125 Query: 332 ILASSGTDRRLNVWD 346 LA G D L ++D Sbjct: 126 KLACLGNDGILRLYD 140 >5WYJ-BE nrPDB Length = 939 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 67/343 (19%), Positives = 128/343 (37%), Gaps = 87/343 (25%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGEC--NPDLRLR---GHQKE 179 G V +A ++ P I+ T D + +Y PS SG+ P LR GH + Sbjct: 296 GGVTQATFLNGQPIIV---TSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQP 352 Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVP--------------KEGKVVDAKTIFTG 225 +++ + S +LSAS D + LW S ++G V TI + Sbjct: 353 PSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSK 410 Query: 226 HTAVVEDV-------SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD-----AHT 273 +V W E++ + D++ WD R+ + + Sbjct: 411 FPEIVALAIENARIGEW----ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSV 466 Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333 A C +F FI GS++ ++ ++++++ L+ ++ HK + + N + Sbjct: 467 AMSQCGNFG----FI---GSSNGSITIYNMQSGILR-KKYKLHKRAVTGISLDGMNRK-M 517 Query: 334 ASSGTDRRLNVWDLSK---IGEEQSPEDAEDGPPELLFIHG------------------- 371 S G D + +D +K +G+ + D P + H Sbjct: 518 VSCGLDGIVGFYDFNKSTLLGKLKL-----DAPITAMVYHRSSDLFALALDDLSIVVIDA 572 Query: 372 ----------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 GH+ +I+ F ++P W++ S S D+ ++ W + Sbjct: 573 VTQRVVRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTWDL 614 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 34/164 (20%), Positives = 72/164 (43%), Gaps = 18/164 (10%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-HKDEIFQ 322 K ++ + ++ LSF L+ G++ + +DL + + ++H ++ H++ Sbjct: 239 KRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDL-DRRSRIHVLKNIHRESYGG 297 Query: 323 VQWSP--HNETILASSGTDRRLN--VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 378 V + + + I+ +SG D L V+D S Q D PP L GGH+ S Sbjct: 298 VTQATFLNGQPIIVTSGGDNSLKEYVFDPSL---SQGSGDVVVQPPRYLRSRGGHSQPPS 354 Query: 379 DFSWNPNEPWVICSVSEDNIM---------QVWQMAENIYNDED 413 ++ ++ + S S+D + Q +M++ ++ +D Sbjct: 355 YIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQD 398 >4MLJ-A nrPDB Length = 306 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 10/29 (34%), Positives = 20/29 (68%) Query: 391 CSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 C +S D I+++++ ENIY ++ G++D Sbjct: 153 CEISTDTIIKLFRDCENIYGVKEASGNID 181 >5M89-A nrPDB Length = 329 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/70 (20%), Positives = 28/70 (40%) Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 335 + L+F+ + ATG +V ++DLR E E+ + W + + Sbjct: 215 IQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATG 274 Query: 336 SGTDRRLNVW 345 GT + ++ Sbjct: 275 GGTGVTVQMY 284 >1VSU-A nrPDB Length = 359 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 4/54 (7%) Query: 63 IHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDAS--HYDSEKGEFGGFGSVSGK 114 I RLVL E+N + + ++ P D ++ A YDS G F G VSGK Sbjct: 33 IGRLVL--RACMERNDITVVAINDPFMDVEYMAYLLKYDSVHGNFNGTVEVSGK 84 >3I2N-A nrPDB Length = 357 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 7/94 (7%) Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED------GPPELL 367 ++HK ++QV+ P N + ++G L++W + ++S +D+E G LL Sbjct: 256 KAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKY-EYPIQRSKKDSEGIEMGVAGSVSLL 314 Query: 368 FIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 T IS W+P++ + S D ++V Sbjct: 315 QNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 >4J0X-A nrPDB Length = 451 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 68/165 (41%), Gaps = 35/165 (21%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD--D 249 H ++ SD+ ICLW ++ K IFT E ++ +L E F ++ D Sbjct: 290 HFITGSDNGNICLWSLA---------KKKPIFT------ERIAHGILPEPSFNDISGETD 334 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW----DLRN 305 ++L + +P + L PYS + +GS ++ +W +LR+ Sbjct: 335 EELRKRQLQGKKLLQPFW--------ITSLYAIPYSN-VFISGSWSGSLKVWKISDNLRS 385 Query: 306 LKL--KLHSFESHKDEIFQVQWSPHNE---TILASSGTDRRLNVW 345 +L +L + +I V+ H + ILAS + RL W Sbjct: 386 FELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 >4CXU-A nrPDB Length = 536 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 6/88 (6%) Query: 151 VFDYTKHPSKPDPSGECNPDLRLRGHQ-KEGYGLSWNPNLSGHLLSASDDHTICLWDISA 209 V D T P+ D +G +P R RG + E G SW LSG +A D++T+ W + Sbjct: 407 VMDVT--PTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAAHDENTVTGWGLFG 464 Query: 210 VPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 + + + D K ++ A V +W L Sbjct: 465 M-RAIRQGDWKAVYL--PAPVGPATWQL 489 >5AJA-A nrPDB Length = 361 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 15/95 (15%) Query: 254 IWDTRSNNTSKPSHSVD-AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 I+D ++ N + D A+ + NC +FNP + +L G LWD+R+ + +H Sbjct: 146 IYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDG------VLWDVRSAQ-AIHK 198 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 F+ I V + P+ ++ ++ +WDL Sbjct: 199 FDKFNMNISGV-FHPNGLEVIINT------EIWDL 226 >3ODT-A nrPDB Length = 313 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 33/146 (22%), Positives = 56/146 (38%), Gaps = 40/146 (27%) Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 +++ AH A V +SE T SADKT+ LW D++ + Sbjct: 136 YNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--------------QNDKVIKTFSG 181 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 HN+ + R L V D + + DG +L+ +H G + ++ +E Sbjct: 182 IHNDVV-------RHLAVVD-----DGHFISCSNDGLIKLVDMHTGDVLR----TYEGHE 225 Query: 387 PWVIC----------SVSEDNIMQVW 402 +V C S ED +++W Sbjct: 226 SFVYCIKLLPNGDIVSCGEDRTVRIW 251 >5VM9-A nrPDB Length = 862 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 24/54 (44%), Gaps = 4/54 (7%) Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 V VSWHLLHE L G + + ++ P H+VD + + + P Sbjct: 130 VSRVSWHLLHEVLTGRTLPEP----LELDKPISTNPVHAVDVVLRHLPSMKYTP 179 >5ZKS-A nrPDB Length = 445 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 20/41 (48%) Query: 55 RPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 95 RPEG I RL GT NH+V V + D+ F+A Sbjct: 350 RPEGATPVIIRLTAGTGNFVSTNHVVAMDVDAASSDSCFEA 390 >3J3V-O nrPDB Length = 120 Score = 28.1 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 6/71 (8%) Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL------SKIGEEQSPEDAEDG 362 +L+ F S+K Q+ + T+ ++S D+ LNV +K+GE + AE G Sbjct: 30 RLNVFRSNKHIYAQIIDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKG 89 Query: 363 PPELLFIHGGH 373 +++F GG+ Sbjct: 90 ISDVVFDRGGY 100 >5WLC-SG nrPDB Length = 573 Score = 28.1 bits (61), Expect = 6.9, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 68/165 (41%), Gaps = 35/165 (21%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA--DD 249 H ++ SD+ ICLW ++ K IFT E ++ +L E F ++ D Sbjct: 412 HFITGSDNGNICLWSLAK---------KKPIFT------ERIAHGILPEPSFNDISGETD 456 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW----DLRN 305 ++L + +P + L PYS + +GS ++ +W +LR+ Sbjct: 457 EELRKRQLQGKKLLQPFW--------ITSLYAIPYSN-VFISGSWSGSLKVWKISDNLRS 507 Query: 306 LKL--KLHSFESHKDEIFQVQWSPHNE---TILASSGTDRRLNVW 345 +L +L + +I V+ H + ILAS + RL W Sbjct: 508 FELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 >6CHG-A nrPDB Length = 312 Score = 27.7 bits (60), Expect = 9.7, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 85/192 (44%), Gaps = 38/192 (19%) Query: 112 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 SGKI +I+ +GE+ + QN +D+LV++ + + + Sbjct: 12 SGKISTSCQISPDGELIA---ICQN----------TDMLVYEISS-----------SKMM 47 Query: 172 RLRGHQKEGYG-LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 +L KE L W+P+ S + S S+D T+ +I+ + G++ GHTA V Sbjct: 48 KLTTTHKECINCLCWSPD-SKCIASGSEDFTV---EITHII-YGRIRR----LMGHTAPV 98 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 + ++ ++ S + D+ + W S K ++ AH+ V + + IL+ Sbjct: 99 ISICYNN-KGNILCSSSMDESIKEWHVLSGTALK---TMSAHSDAVVSIDIPKFDSSILS 154 Query: 291 TGSADKTVALWD 302 +GS D + ++D Sbjct: 155 SGSYDGLIRIFD 166 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5Y1U-A nrPDB 606 e-174 3C9C-A nrPDB 568 e-162 3CFV-B nrPDB 567 e-162 5WJC-A nrPDB 438 e-123 4XYI-A nrPDB 411 e-115 4PSX-B nrPDB 361 e-100 6HQA-B nrPDB 216 1e-56 4V6W-Ag nrPDB 205 3e-53 6MZM-G nrPDB 200 8e-52 6F3T-A nrPDB 198 4e-51 3DM0-A nrPDB 196 2e-50 6G51-g nrPDB 195 2e-50 5MZH-A nrPDB 180 8e-46 5M25-A nrPDB 180 1e-45 2H9P-A nrPDB 176 2e-44 6QX9-5O nrPDB 175 3e-44 4BTS-AR nrPDB 175 4e-44 4V8M-A7 nrPDB 174 5e-44 5NNZ-B nrPDB 172 2e-43 5G04-R nrPDB 170 8e-43 4A11-B nrPDB 169 2e-42 4GGA-A nrPDB 169 2e-42 3FM0-A nrPDB 169 2e-42 5LCW-Q nrPDB 168 3e-42 1VYH-C nrPDB 168 6e-42 5FL8-q nrPDB 167 1e-41 5OPT-p nrPDB 166 1e-41 4V7E-Bg nrPDB 166 2e-41 6QX9-4B nrPDB 166 2e-41 3W15-A nrPDB 166 2e-41 3JRO-A nrPDB 162 2e-40 5GAN-H nrPDB 161 4e-40 6ID0-T nrPDB 160 1e-39 6HHQ-h nrPDB 159 2e-39 4N14-A nrPDB 156 2e-38 6N9G-C nrPDB 153 2e-37 3JRP-A nrPDB 152 3e-37 3JB9-L nrPDB 150 8e-37 5A9Q-0 nrPDB 150 1e-36 2PM9-A nrPDB 149 2e-36 3JAP-g nrPDB 149 3e-36 5Y88-O nrPDB 148 4e-36 2AQ5-A nrPDB 148 6e-36 5XYI-g nrPDB 148 7e-36 5NZU-C nrPDB 147 7e-36 4BZK-B nrPDB 147 9e-36 4YCZ-A nrPDB 146 2e-35 6F1U-h nrPDB 146 2e-35 4L9O-A nrPDB 145 3e-35 5WYJ-BC nrPDB 144 1e-34 5UZ7-B nrPDB 143 1e-34 5A31-R nrPDB 141 6e-34 6EOJ-D nrPDB 140 1e-33 3MKQ-A nrPDB 138 3e-33 5OQL-d nrPDB 138 5e-33 5Z56-q nrPDB 136 2e-32 2YNP-A nrPDB 135 3e-32 5OQL-J nrPDB 134 5e-32 2HES-X nrPDB 134 6e-32 6QDV-o nrPDB 134 8e-32 3JB9-g nrPDB 134 8e-32 5L9T-R nrPDB 134 1e-31 5WLC-LO nrPDB 134 1e-31 4LG8-A nrPDB 134 1e-31 4AEZ-A nrPDB 131 8e-31 5WLC-LU nrPDB 130 1e-30 6J6H-n nrPDB 127 1e-29 5FA5-B nrPDB 126 2e-29 5FVM-C nrPDB 125 4e-29 3BG0-A nrPDB 120 1e-27 6EMK-B nrPDB 119 3e-27 4G56-B nrPDB 116 2e-26 1NR0-A nrPDB 112 4e-25 5OQL-L nrPDB 109 2e-24 4BH6-A nrPDB 109 3e-24 6ELZ-p nrPDB 107 8e-24 5CXC-A nrPDB 106 1e-23 4E5Z-B nrPDB 91 1e-18 5WLC-LJ nrPDB 89 4e-18 3EI3-B nrPDB 80 2e-15 6E29-D nrPDB 74 8e-14 6BX3-B nrPDB 73 3e-13 Sequences not found previously or not previously below threshold: 5YZG-W nrPDB 134 8e-32 5I2T-A nrPDB 133 2e-31 6Q8F-A nrPDB 121 6e-28 5K1B-B nrPDB 119 3e-27 4J0W-A nrPDB 114 7e-26 3ODT-A nrPDB 111 7e-25 5WYK-BB nrPDB 111 7e-25 4XFV-A nrPDB 105 3e-23 3F3P-A nrPDB 104 6e-23 5A9Q-7 nrPDB 103 1e-22 6GMH-W nrPDB 103 1e-22 6BX3-A nrPDB 102 4e-22 5WBU-D nrPDB 97 2e-20 5WYJ-BE nrPDB 96 2e-20 1PI6-A nrPDB 94 8e-20 6CHG-A nrPDB 94 1e-19 5N4A-A nrPDB 93 2e-19 4U1E-I nrPDB 91 1e-18 5A9Q-2 nrPDB 90 2e-18 3I2N-A nrPDB 90 2e-18 5K0Y-T nrPDB 85 6e-17 5BJS-A nrPDB 83 3e-16 4OWR-A nrPDB 79 3e-15 5MWJ-A nrPDB 78 5e-15 5M89-A nrPDB 78 6e-15 5OQL-X nrPDB 77 2e-14 3ACP-A nrPDB 76 2e-14 3JZG-A nrPDB 74 1e-13 3DW8-B nrPDB 73 3e-13 6CB1-s nrPDB 73 4e-13 6C0F-s nrPDB 72 4e-13 6EM1-m nrPDB 72 6e-13 2P9P-C nrPDB 70 2e-12 5OV3-A nrPDB 70 2e-12 5YZG-2 nrPDB 70 2e-12 4J0X-A nrPDB 68 7e-12 5WLC-SG nrPDB 67 1e-11 5CXB-B nrPDB 67 1e-11 5K19-A nrPDB 66 3e-11 5WLC-LN nrPDB 62 6e-10 5MC6-j nrPDB 61 1e-09 5TF2-A nrPDB 59 4e-09 6CHG-D nrPDB 59 5e-09 3DWL-C nrPDB 58 8e-09 5WLC-LW nrPDB 55 7e-08 3JB9-S nrPDB 53 3e-07 6CVZ-A nrPDB 51 1e-06 4FHN-A nrPDB 50 2e-06 2VDU-B nrPDB 49 3e-06 5WLC-LV nrPDB 49 4e-06 5LTD-A nrPDB 48 7e-06 5WLC-LS nrPDB 47 1e-05 2I3T-A nrPDB 47 1e-05 5WLC-LH nrPDB 46 4e-05 6IYY-A nrPDB 43 2e-04 5K1H-B nrPDB 42 5e-04 5AMS-A nrPDB 41 0.001 6NAU-A nrPDB 36 0.031 4YHC-A nrPDB 36 0.031 1C5K-A nrPDB 35 0.054 4R40-A nrPDB 35 0.077 1RI6-A nrPDB 34 0.14 5GRS-A nrPDB 34 0.15 6N8P-A nrPDB 34 0.16 5CWW-B nrPDB 34 0.16 5BPW-A nrPDB 33 0.26 6GC1-A nrPDB 33 0.27 5AJA-A nrPDB 33 0.28 4AV8-A nrPDB 32 0.40 4MDV-A nrPDB 31 0.98 5XQL-A nrPDB 30 1.6 6IGR-A nrPDB 30 1.9 1K3I-A nrPDB 30 2.1 1OI2-A nrPDB 29 2.7 6HA9-A nrPDB 29 3.1 3LV4-A nrPDB 29 3.7 3U14-A nrPDB 29 4.5 >5Y1U-A nrPDB Length = 456 Score = 606 bits (1562), Expect = e-174, Method: Composition-based stats. Identities = 425/425 (100%), Positives = 425/425 (100%) Query: 1 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD Sbjct: 32 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 91 Query: 61 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK Sbjct: 92 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 151 Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG Sbjct: 152 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 211 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE Sbjct: 212 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 271 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE Sbjct: 332 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 391 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP Sbjct: 392 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 451 Query: 421 EGQGS 425 EGQGS Sbjct: 452 EGQGS 456 >3C9C-A nrPDB Length = 432 Score = 568 bits (1464), Expect = e-162, Method: Composition-based stats. Identities = 376/409 (91%), Positives = 400/409 (97%) Query: 7 AFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRL 66 +FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVT+ +GKD+S+HRL Sbjct: 13 SFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRL 72 Query: 67 VLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126 +LGTHTSDEQNHL+IASVQLP++DAQFD SHYD+EKGEFGGFGSV GKIEIEIKINHEGE Sbjct: 73 ILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 132 Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 186 VNRARYMPQN C+IATKTPSSDVLVFDYTKHPSKP+PSGEC PDLRLRGHQKEGYGLSWN Sbjct: 133 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWN 192 Query: 187 PNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSV 246 PNL+G+LLSASDDHTICLWDI+A PKE +V+DAK IFTGHTAVVEDV+WHLLHESLFGSV Sbjct: 193 PNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSV 252 Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 ADDQKLMIWDTR+NNTSKPSH+VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL Sbjct: 253 ADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 312 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL+VWDLSKIGEEQS EDAEDGPPEL Sbjct: 313 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 372 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 LFIHGGHTAKISDFSWNPNEPW+ICSVSEDNIMQVWQMAEN+YNDE+PE Sbjct: 373 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPE 421 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 40/164 (24%), Positives = 67/164 (40%), Gaps = 16/164 (9%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H EVN + P + I+AT + V ++D K H+ E + Sbjct: 277 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH---------SFESHKDEIF 327 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT-------IFTGHTAVVEDVS 234 + W+P+ L S+ D + +WD+S + +E DA+ I GHTA + D S Sbjct: 328 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 387 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 W+ + SV++D + +W N + + A E N Sbjct: 388 WNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 431 >3CFV-B nrPDB Length = 414 Score = 567 bits (1462), Expect = e-162, Method: Composition-based stats. Identities = 375/412 (91%), Positives = 394/412 (95%), Gaps = 1/412 (0%) Query: 1 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60 MA KE F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD Sbjct: 4 MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 62 Query: 61 FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120 +++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIK Sbjct: 63 YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK 122 Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 INHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEG Sbjct: 123 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 YGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHE Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 SLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVAL Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WDLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAE Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDE 414 Score = 77.9 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 32/152 (21%), Positives = 60/152 (39%), Gaps = 16/152 (10%) Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDL---------RNLKLKLHSFESHKDEIFQ 322 H EVN + P + I+AT + V ++D H+ E + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 323 VQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 + W+ + L S+ D + +WD++ +E DA+ I GH+A + D +W Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKA-------IFTGHSAVVEDVAW 237 Query: 383 NPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 + + SV++D + +W N + Sbjct: 238 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSH 269 >5WJC-A nrPDB Length = 430 Score = 438 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 211/412 (51%), Positives = 278/412 (67%), Gaps = 21/412 (5%) Query: 14 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS 73 ++ I EEYK+WK+N PFLYDLV+THALEWPSLT QWLPD G D+SI RL+LGTHTS Sbjct: 23 QKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTS 82 Query: 74 -DEQNHLVIASVQLPNDDAQFDASHYDSEKGEFG------GFGSVSGKIEIEIKINHEGE 126 ++QN+L IASVQLPN +D + EF + S IEI KI H+G+ Sbjct: 83 GNDQNYLQIASVQLPN---------FDEDTTEFTPSTIRRAQATGSYTIEISQKIPHDGD 133 Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 186 VNRARYMPQ P IIAT + +FD T H + +GE P L+GH EG+GL WN Sbjct: 134 VNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALT--TGEALPQAVLKGHTAEGFGLCWN 191 Query: 187 PNLSGHLLSASDDHTICLWDISA---VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF 243 PNL G+L + ++D ICLWD+ E KV+ + HT +V DV +H HE+L Sbjct: 192 PNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALL 251 Query: 244 GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 SV+DD L I DTR N + + AH+ +N ++ NP+++++LAT SADKTVALWDL Sbjct: 252 ASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDL 311 Query: 304 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP 363 RN +LH+ E H+DE++ ++WSPH+E ILASS TDRR+ +WDL KIGEEQ+PEDAEDG Sbjct: 312 RNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGS 371 Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 PELLF+HGGHT +IS+FSW PNE WV+ S+++DNI+Q+W + I+ + + Sbjct: 372 PELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGRDHVQ 423 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 46/210 (21%), Positives = 85/210 (40%), Gaps = 28/210 (13%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDT-----RSNNTSKPSHSVDAHTAEVNCLS 280 H V + + ++ + I+DT + + P + HTAE L Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 281 FNPYSEFILATGSADKTVALWDLRNLKL---------KLHSFESHKDEIFQVQWSPHNET 331 +NP LATG+ D+ + LWD++ + + H D + VQ+ P +E Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 332 ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC 391 +LAS D L + D EE++P+ + H+ I+ + NP +++ Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPK-----------VIQAHSKAINAVAINPFNDYLLA 298 Query: 392 SVSEDNIMQVWQMA---ENIYNDEDPEGSV 418 + S D + +W + + ++ E E V Sbjct: 299 TASADKTVALWDLRNPYQRLHTLEGHEDEV 328 >4XYI-A nrPDB Length = 430 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 194/408 (47%), Positives = 272/408 (66%), Gaps = 25/408 (6%) Query: 14 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS 73 E+ I EEYK+WK+N PFLYDLV+T ALEWPSLT +W P R + SI +L+LGT TS Sbjct: 23 EKKIQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSLADNSSIQKLLLGTQTS 82 Query: 74 -DEQNHLVIASVQLPN--------DDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHE 124 ++QN+L +ASVQLP ++ +++ KG++G ++I KI+HE Sbjct: 83 GNDQNYLQVASVQLPTFDDDLDDLTPSKMKPANF---KGDYG--------LDIVQKIHHE 131 Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 G+VN+AR+MPQNP IIAT + + +FD + + P + LR H EG+GL Sbjct: 132 GDVNKARFMPQNPDIIATLGLNGNGYIFDLNLY--REQPIVQTGHQACLRHHTSEGFGLG 189 Query: 185 WNPNLSGHLLSASDDHTICLWDISAVP---KEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 WN G L + ++D +IC+WDI ++ V +++ HTAVV D+ +HL HE+ Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L SV+DD L I DTR ++S S V AH VN ++FNP+++++LAT SAD TVALW Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 DLR L +LH+ E H+DE++ VQWSPH+E IL +S TDRR+ VWDLSKIGEEQ+ ED+ED Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 G PEL+F+HGGHT ++SD SWNPN WV+ S+++DNI+Q+W ++ I+ Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIW 417 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 80/210 (38%), Gaps = 28/210 (13%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDT---RSNNTSKPSHS--VDAHTAEVNCLS 280 H V + + + ++ + I+D R + H + HT+E L Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 281 FNPYSEFILATGSADKTVALWDLRNLKL---------KLHSFESHKDEIFQVQWSPHNET 331 +N E LATG+ D ++ +WD++ L + + H + +Q+ +E Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 332 ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC 391 +L S D L + D + + + H ++ ++NP +++ Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVK-----------AHEQPVNGVAFNPFNDYLLA 298 Query: 392 SVSEDNIMQVWQMA---ENIYNDEDPEGSV 418 + S D+ + +W + + ++ E E V Sbjct: 299 TASADHTVALWDLRRLNQRLHTLEGHEDEV 328 >4PSX-B nrPDB Length = 401 Score = 361 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 149/399 (37%), Positives = 222/399 (55%), Gaps = 29/399 (7%) Query: 17 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS-DE 75 ++EEY +WK N P +YD V L WPSLT QWLP + F L++GTHTS +E Sbjct: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 Query: 76 QNHLVIASVQLP-----NDDAQFDASH-YDSEKGEFGGFGSVSGKIEIEIKINHEGEVNR 129 +N+L A + LP N+D Q +A Y S + I I K HE E+ R Sbjct: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQS------SLPAPRSNIRITAKYEHEEEITR 123 Query: 130 ARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNL 189 ARYMPQ+P I+AT ++ ++ L+ H+ GY LS++ + Sbjct: 124 ARYMPQDPNIVATINGQGTTFLYSRSEGLQST-----------LKFHKDNGYALSFSTLV 172 Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 G LLS SDDHT+ LW++ + K V H+ ++ D WH ++ LFG+V++D Sbjct: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSED 230 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 L I D R+NNT+ + N L+F+ +S +LA D V L+DLRN+K Sbjct: 231 SLLKINDVRANNTTIDTVKC---PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 LH H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+P+DAEDG PEL+ + Sbjct: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 H GH + ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 >6HQA-B nrPDB Length = 722 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 133/332 (40%), Gaps = 45/332 (13%) Query: 108 FGSVSGKIEIEIKINHEGEVNRARYMPQNPC--IIATKTPSSDVLVFDYTKHPS----KP 161 + + N + N ++A+ S + ++ P K Sbjct: 371 LSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKN 430 Query: 162 DPSGECNPD-------LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG 214 DP + N D RL GH YG+ ++P+ + +L+S S+D T+ LW + Sbjct: 431 DPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLD------ 483 Query: 215 KVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 + GH++ V DV + + F + + DQ +W S + P H Sbjct: 484 -TYTCLVSYKGHSSSVWDVKFSPMG-HYFATASHDQTARLW---SCDHIYPLRIFAGHLN 538 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334 +V+C+ F+P S ++ TGS+DKT +WD+ + + F H I + SP LA Sbjct: 539 DVDCVEFHPNSTYLF-TGSSDKTARMWDIARGEC-VRVFMGHSGAINCLAVSPDGRW-LA 595 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH-TAKISDFSWNPNEPWVICSV 393 S+G D + +WD+S + GH + I +++ V+ S Sbjct: 596 SAGEDSVVCLWDISTG--------------RRIKAMRGHGRSSIYSLAFSREGT-VLVST 640 Query: 394 SEDNIMQVWQMAENIYN-DEDPEGSVDPEGQG 424 DN ++VW + +N + PE D QG Sbjct: 641 GADNSVRVWDVKKNTNSPSAQPEPINDVTAQG 672 >4V6W-Ag nrPDB Length = 318 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 131/307 (42%), Gaps = 35/307 (11%) Query: 119 IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 I H G V + P++P I + + ++V+ T+ + + P RL GH Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTR----DEDTNYGYPQKRLYGHSH 65 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 + + + + LS S D T+ LWD++A F GHT V V++ Sbjct: 66 FISDVVLSSD-GNYALSGSWDQTLRLWDLAAG-------KTTRRFEGHTKDVLSVAFSAD 117 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP-YSEFILATGSADKT 297 + + S + D+ + +W+T + K + D HT V+C+ F+P +S I+ + D+T Sbjct: 118 NRQIV-SGSRDKTIKLWNTLAEC--KFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRT 174 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE 357 V +W+L N KLK ++ H + V SP ++ S G D + +WDL+ + E Sbjct: 175 VKVWNLANCKLK-NNHHGHNGYLNTVTVSPDG-SLCTSGGKDSKALLWDLNDGKNLYTLE 232 Query: 358 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 H I+ ++PN W+ + +++W +A +E Sbjct: 233 ---------------HNDIINALCFSPNRYWLCVAYG--PSIKIWDLACKKTVEELRPEV 275 Query: 418 VDPEGQG 424 V P + Sbjct: 276 VSPTSKA 282 >6MZM-G nrPDB Length = 800 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 67/243 (27%), Positives = 112/243 (46%), Gaps = 30/243 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH YG S++P+ +LLS+S+D T+ LW + + + GH V D Sbjct: 539 LYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 590 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + F S D+ +W + + +P H A+VNC F+P S + +ATG Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATG 645 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 SAD+TV LWD+ N + F HK I + +SP+ LA+ TD R+ +WD+ Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI----- 698 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 G ++ GHT + ++ + ++ S S DN +++W + + E Sbjct: 699 ---------GHGLMVGELKGHTDTVCSLRFSRDG-EILASGSMDNTVRLWDAIKAFEDLE 748 Query: 413 DPE 415 + Sbjct: 749 TDD 751 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 96/250 (38%), Gaps = 26/250 (10%) Query: 119 IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 I H G V A + P + + + + V ++ + +GH Sbjct: 538 ILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTF----------TCLVGYKGHNY 586 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 + ++P + +S D LW IF GH A V +H Sbjct: 587 PVWDTQFSP-YGYYFVSGGHDRVARLW-------ATDHYQPLRIFAGHLADVNCTRFHP- 637 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 + + + + D+ + +WD + N + H ++ L+F+P F LATG+ D V Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVR---IFTGHKGPIHSLTFSPNGRF-LATGATDGRV 693 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 LWD+ + L + + H D + +++S E ILAS D + +WD K E+ +D Sbjct: 694 LLWDIGHG-LMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLETDD 751 Query: 359 AEDGPPELLF 368 + Sbjct: 752 FTTATGHINL 761 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 71/192 (36%), Gaps = 22/192 (11%) Query: 221 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 280 I GH+ V S+ + S ++D + +W S T H V Sbjct: 537 KILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLW---SLQTFTCLVGYKGHNYPVWDTQ 592 Query: 281 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 340 F+PY + +G D+ LW + L F H ++ ++ P N +A+ DR Sbjct: 593 FSPYG-YYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADR 649 Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 + +WD+ + I GH I +++PN + + + + D + Sbjct: 650 TVRLWDVLNG--------------NCVRIFTGHKGPIHSLTFSPNGRF-LATGATDGRVL 694 Query: 401 VWQMAENIYNDE 412 +W + + E Sbjct: 695 LWDIGHGLMVGE 706 >6F3T-A nrPDB Length = 608 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 127/301 (42%), Gaps = 51/301 (16%) Query: 136 NPCIIATKTPSSDVLVF--------------DYTKHPSKPDPSGECNPDLR-------LR 174 + +IA S V V+ D + + D E D + L Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 348 Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH YG S++P+ +LLS+S+D T+ LW + + + GH V D Sbjct: 349 GHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWDTQ 400 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + F S D+ +W + + +P H A+VNC F+P S + +ATGSA Sbjct: 401 FSP-YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSA 455 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 D+TV LWD+ N + F HK I + +SP+ LA+ TD R+ +WD+ Sbjct: 456 DRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSPNGR-FLATGATDGRVLLWDI------- 506 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 G ++ GHT + ++ + ++ S S DN +++W + + E Sbjct: 507 -------GHGLMVGELKGHTDTVCSLRFSRDG-EILASGSMDNTVRLWDAIKAFEDLETD 558 Query: 415 E 415 + Sbjct: 559 D 559 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 99/253 (39%), Gaps = 26/253 (10%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 E++I H G V A + P + + + + V ++ + +G Sbjct: 343 ELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTF----------TCLVGYKG 391 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H + ++P + +S D LW IF GH A V + Sbjct: 392 HNYPVWDTQFSP-YGYYFVSGGHDRVARLW-------ATDHYQPLRIFAGHLADVNCTRF 443 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 H + + + + D+ + +WD + N + H ++ L+F+P F LATG+ D Sbjct: 444 HP-NSNYVATGSADRTVRLWDVLNGNCVR---IFTGHKGPIHSLTFSPNGRF-LATGATD 498 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 V LWD+ + L + + H D + +++S E ILAS D + +WD K E+ Sbjct: 499 GRVLLWDIGHG-LMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLE 556 Query: 356 PEDAEDGPPELLF 368 +D + Sbjct: 557 TDDFTTATGHINL 569 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 86/249 (34%), Gaps = 46/249 (18%) Query: 188 NLSGHLLSASDDHTICLW--------------DISAVPKEG----------KVVDAKTIF 223 + S + D T+ +W D+S + KE K I Sbjct: 288 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 347 Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 GH+ V S+ + S ++D + +W S T H V F+P Sbjct: 348 YGHSGPVYGASFSP-DRNYLLSSSEDGTVRLW---SLQTFTCLVGYKGHNYPVWDTQFSP 403 Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 Y + +G D+ LW + L F H ++ ++ P N +A+ DR + Sbjct: 404 YG-YYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVR 460 Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 +WD+ + I GH I +++PN + + + + D + +W Sbjct: 461 LWDVLNG--------------NCVRIFTGHKGPIHSLTFSPNGRF-LATGATDGRVLLWD 505 Query: 404 MAENIYNDE 412 + + E Sbjct: 506 IGHGLMVGE 514 >3DM0-A nrPDB Length = 694 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 119/287 (41%), Gaps = 34/287 (11%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V N II + + ++++ TK D RL GH Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTK-----DDKAYGVAQRRLTGHSHFVE 434 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + LS S D + LWD++A + F GHT V V++ L + Sbjct: 435 DVVLSSD-GQFALSGSWDGELRLWDLAAGVSTRR-------FVGHTKDVLSVAFSLDNRQ 486 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVAL 300 + S + D+ + +W+T S + H V+C+ F+P + + + + S DKTV + Sbjct: 487 IV-SASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 W+L N KL+ + H + V SP ++ AS G D + +WDL++ + S E Sbjct: 546 WNLSNCKLR-STLAGHTGYVSTVAVSPDG-SLCASGGKDGVVLLWDLAEGKKLYSLE--- 600 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + I ++PN W +C+ +E +++W + Sbjct: 601 ------------ANSVIHALCFSPNRYW-LCAATEHG-IKIWDLESK 633 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 111/240 (46%), Gaps = 29/240 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 +R H ++ + + ++SAS D +I LW ++ K V A+ TGH+ VED Sbjct: 378 MRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGV--AQRRLTGHSHFVED 435 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V + S + D +L +WD + +++ HT +V ++F+ + I+ + Sbjct: 436 VVLSSDGQFAL-SGSWDGELRLWDLAAGVSTR---RFVGHTKDVLSVAFSLDNRQIV-SA 490 Query: 293 SADKTVALWDLRNLKLKLHSF----ESHKDEIFQVQWSPHN-ETILASSGTDRRLNVWDL 347 S D+T+ LW+ L ++ E H+D + V++SP+ + + S+ D+ + VW+L Sbjct: 491 SRDRTIKLWN--TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL 548 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 S + GHT +S + +P+ + S +D ++ +W +AE Sbjct: 549 SNCKLRSTL--------------AGHTGYVSTVAVSPDGS-LCASGGKDGVVLLWDLAEG 593 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 46/225 (20%), Positives = 89/225 (39%), Gaps = 17/225 (7%) Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 244 W + + +AS T+ +A + K HT +V ++ + + + Sbjct: 340 WYAVRTAVINAASGRQTVDAALAAAQTNAAAGLVLKGTMRAHTDMVTAIATPIDNADIIV 399 Query: 245 SVADDQKLMIWDTRSNNT--SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 S + D+ +++W ++ + H+ V + + +F L +GS D + LWD Sbjct: 400 SASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFAL-SGSWDGELRLWD 458 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 L + F H ++ V +S N I+ S+ DR + +W+ + E E Sbjct: 459 LAAG-VSTRRFVGHTKDVLSVAFSLDNRQIV-SASRDRTIKLWNTLGECKYTISEGGE-- 514 Query: 363 PPELLFIHGGHTAKISDFSWNPNE-PWVICSVSEDNIMQVWQMAE 406 GH +S ++PN I S S D ++VW ++ Sbjct: 515 ---------GHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 98/274 (35%), Gaps = 51/274 (18%) Query: 100 SEKGEFGGFGSVSGKIEIEIK---------INHEGEVNRARYMPQNPCIIATKTPSSDVL 150 S G+F GS G++ + + H +V + N I+ + + + Sbjct: 439 SSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIV-SASRDRTIK 497 Query: 151 VFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNL-SGHLLSASDDHTICLWDISA 209 +++ G GH+ + ++PN ++SAS D T+ +W++S Sbjct: 498 LWNTLGECKYTISEGG-------EGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Query: 210 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 269 ++ GHT V V+ L S D +++WD K +S+ Sbjct: 551 C-------KLRSTLAGHTGYVSTVAVSPDGS-LCASGGKDGVVLLWDLAEG---KKLYSL 599 Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL---------KLHSFESHKDE- 319 +A + ++ L F+P + + L + + +WDL + + + Sbjct: 600 EA-NSVIHALCFSP-NRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKADNSGPA 656 Query: 320 --------IFQVQWSPHNETILASSGTDRRLNVW 345 + WS T+ S TD + VW Sbjct: 657 ATKRKVIYCTSLNWSADGSTLF-SGYTDGVIRVW 689 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 53/145 (36%), Gaps = 20/145 (13%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALW----DLRNLKLKLHSFESHKDEIFQV 323 ++ AHT V ++ + I+ + S DK++ LW D + + H + V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 S + S D L +WDL+ + GHT + +++ Sbjct: 437 VLS-SDGQFALSGSWDGELRLWDLAAGVSTRR--------------FVGHTKDVLSVAFS 481 Query: 384 PNEPWVICSVSEDNIMQVWQMAENI 408 + ++ S S D +++W Sbjct: 482 LDNRQIV-SASRDRTIKLWNTLGEC 505 >6G51-g nrPDB Length = 317 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 126/304 (41%), Gaps = 36/304 (11%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H G V + PQ P +I + + ++++ T+ D + P LRGH Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR-----DETNYGIPQRALRGHSHFVS 67 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + LS S D T+ LWD++ F GHT V V++ + Sbjct: 68 DVVISSD-GQFALSGSWDGTLRLWDLTTG-------TTTRRFVGHTKDVLSVAFSSDNRQ 119 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF-ILATGSADKTVAL 300 + S + D+ + +W+T + ++H+ V+C+ F+P S I+ + DK V + Sbjct: 120 IV-SGSRDKTIKLWNTLGVCKY--TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 W+L N KLK + H + V SP ++ AS G D + +WDL++ + + + Sbjct: 177 WNLANCKLKTNHI-GHTGYLNTVTVSPDG-SLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420 I+ ++PN W+ + +++W + I DE + + Sbjct: 235 ---------------IINALCFSPNRYWLCAATG--PSIKIWDLEGKIIVDELKQEVIST 277 Query: 421 EGQG 424 + Sbjct: 278 SSKA 281 >5MZH-A nrPDB Length = 452 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 111/292 (38%), Gaps = 40/292 (13%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 E+ H+ V + I T + ++D +G+ L+G Sbjct: 128 EVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWD--------AYTGQLY--YTLKG 177 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 HQ E LS+NP S + + S D+T LWD+ + + GH A + + + Sbjct: 178 HQTEIVCLSFNP-QSTIIATGSMDNTAKLWDVETGQE-------RATLAGHRAEIVSLGF 229 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + L + + D +WD R+ H + H EV+ FN Y+ ++ +GS D Sbjct: 230 N-TGGDLIVTGSFDHDSRLWDVRTGQC---VHVLSGHRGEVSSTQFN-YAGTLVVSGSID 284 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 T LWD+R+ + L + H DE+ V + ++ S+ D ++ Sbjct: 285 CTSRLWDVRSGRC-LSVKQGHTDEVLDVAFDAAGTKMV-SASADGSARLY---------- 332 Query: 356 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 GH +IS ++NP +I + S D ++W Sbjct: 333 ----HTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-TASSDKTCRLWDCDTG 379 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 93/236 (39%), Gaps = 29/236 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 LR H ++N ++ S D T +W+ + GH VV Sbjct: 90 LRAHILPLTNCAFN-KSGDRFITGSYDRTCKVWNTFTGEE-------VFTLEGHKNVVYA 141 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 ++++ + + + D+ +WD + +++ H E+ CLSFNP I+ATG Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLWDAYTGQLY---YTLKGHQTEIVCLSFNP-QSTIIATG 197 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D T LWD+ + + + H+ EI + ++ ++ + D +WD+ Sbjct: 198 SMDNTAKLWDVETGQER-ATLAGHRAEIVSLGFN-TGGDLIVTGSFDHDSRLWDVRTG-- 253 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 + + + GH ++S +N ++ S S D ++W + Sbjct: 254 ------------QCVHVLSGHRGEVSSTQFNYAGT-LVVSGSIDCTSRLWDVRSGR 296 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 74/188 (39%), Gaps = 24/188 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H GEV+ ++ ++ + + ++D SG C + GH E Sbjct: 261 GHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVR--------SGRCLSVKQ--GHTDEVL 309 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 ++++ ++SAS D + L+ + GH + V+++ Sbjct: 310 DVAFDA-AGTKMVSASADGSARLYHTLTGV-------CQHTLVGHEGEISKVAFNPQGTR 361 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L + + D+ +WD +T + ++ HT E+ +FN +FI+ TGS D T +W Sbjct: 362 LI-TASSDKTCRLWD---CDTGECLQVLEGHTDEIFSCAFNYEGDFII-TGSKDNTCRIW 416 Query: 302 DLRNLKLK 309 + Sbjct: 417 KALTASSQ 424 >5M25-A nrPDB Length = 434 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 120/286 (41%), Gaps = 37/286 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V+ ++ P N +A+ + + ++ + + GH+ Sbjct: 143 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKF----------EKTISGHKLGIS 191 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 ++W+ + S L+SASDD T+ +WD+S+ GH+ V +++ + Sbjct: 192 DVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSN 242 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L S + D+ + IWD ++ K ++ AH+ V+ + FN I+++ S D +W Sbjct: 243 LIVSGSFDESVRIWDVKTGKCLK---TLPAHSDPVSAVHFNRDGSLIVSS-SYDGLCRIW 298 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 D + + + + V++SP+ + ILA++ D L +WD SK G+ Sbjct: 299 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GKCLKTYTGHK 356 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 +F + ++ I S SEDN++ +W + Sbjct: 357 NEKYCIFAN-----------FSVTGGKWIVSGSEDNLVYIWNLQTK 391 Score = 168 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 59/235 (25%), Positives = 108/235 (45%), Gaps = 29/235 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH K + ++PN L S+S D I +W + +GH + D Sbjct: 141 LAGHTKAVSSVKFSPN-GEWLASSSADKLIKIW-------GAYDGKFEKTISGHKLGISD 192 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V+W +L S +DD+ L IWD S K ++ H+ V C +FNP S I+ +G Sbjct: 193 VAWS-SDSNLLVSASDDKTLKIWDVSSGKCLK---TLKGHSNYVFCCNFNPQSNLIV-SG 247 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D++V +WD++ K L + +H D + V ++ +++ SS D +WD + Sbjct: 248 SFDESVRIWDVKTGKC-LKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQC 305 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 ++ D ++ P +S ++PN +++ + DN +++W ++ Sbjct: 306 LKTLIDDDNPP-------------VSFVKFSPNGKYILA-ATLDNTLKLWDYSKG 346 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 77/376 (20%), Positives = 150/376 (39%), Gaps = 59/376 (15%) Query: 33 DLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQ 92 D++ H + Q P +P ++++ + L HT ++SV+ + Sbjct: 110 DIIEAHREQIGGSATQSKPTPVKP---NYAL-KFTLAGHTK------AVSSVKFSPNGEW 159 Query: 93 FDASHYDSEKGEFGGF-GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLV 151 +S D +G + G I H+ ++ + + ++ + + + + Sbjct: 160 LASSSADKLIKIWGAYDGKFEKTIS-----GHKLGISDVAWSS-DSNLLVSASDDKTLKI 213 Query: 152 FDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVP 211 +D + SG+C L+GH + ++NP S ++S S D ++ +WD+ Sbjct: 214 WDVS--------SGKCLK--TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDV---- 258 Query: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA 271 K H+ V V ++ SL S + D IWDT S K +D Sbjct: 259 ---KTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDD 312 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV--QWSPHN 329 V+ + F+P ++ILA + D T+ LWD K L ++ HK+E + + +S Sbjct: 313 DNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFANFSVTG 370 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 + S D + +W+L E++ GHT + + +P E + Sbjct: 371 GKWIVSGSEDNLVYIWNLQT--------------KEIVQKLQGHTDVVISTACHPTE-NI 415 Query: 390 ICSVS--EDNIMQVWQ 403 I S + D +++W+ Sbjct: 416 IASAALENDKTIKLWK 431 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 39/155 (25%), Positives = 68/155 (43%), Gaps = 18/155 (11%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327 ++ HT V+ + F+P E+ LA+ SADK + +W + K + + HK I V WS Sbjct: 140 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS- 196 Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 387 + +L S+ D+ L +WD+S + L GH+ + ++NP + Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSG--------------KCLKTLKGHSNYVFCCNFNP-QS 241 Query: 388 WVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEG 422 +I S S D +++W + P S Sbjct: 242 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 276 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 23/47 (48%), Gaps = 1/47 (2%) Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 L F GHT +S ++PN W + S S D ++++W + + Sbjct: 137 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT 182 >2H9P-A nrPDB Length = 329 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 120/286 (41%), Gaps = 37/286 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V+ ++ P N +A+ + + ++ + + GH+ Sbjct: 38 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKF----------EKTISGHKLGIS 86 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 ++W+ + S L+SASDD T+ +WD+S+ GH+ V +++ + Sbjct: 87 DVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSN 137 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L S + D+ + IWD ++ K ++ AH+ V+ + FN I+++ S D +W Sbjct: 138 LIVSGSFDESVRIWDVKTGKCLK---TLPAHSDPVSAVHFNRDGSLIVSS-SYDGLCRIW 193 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 D + + + + V++SP+ + ILA++ D L +WD SK G+ Sbjct: 194 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GKCLKTYTGHK 251 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 +F + ++ I S SEDN++ +W + Sbjct: 252 NEKYCIFAN-----------FSVTGGKWIVSGSEDNLVYIWNLQTK 286 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 59/235 (25%), Positives = 109/235 (46%), Gaps = 29/235 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH K + ++PN L S+S D I +W + +GH + D Sbjct: 36 LAGHTKAVSSVKFSPN-GEWLASSSADKLIKIW-------GAYDGKFEKTISGHKLGISD 87 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V+W +L S +DD+ L IWD S K ++ H+ V C +FNP S I+ +G Sbjct: 88 VAWS-SDSNLLVSASDDKTLKIWDVSSGKCLK---TLKGHSNYVFCCNFNPQSNLIV-SG 142 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D++V +WD++ K L + +H D + V ++ + +++ SS D +WD + Sbjct: 143 SFDESVRIWDVKTGKC-LKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQC 200 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 ++ D ++ P +S ++PN +++ + DN +++W ++ Sbjct: 201 LKTLIDDDNPP-------------VSFVKFSPNGKYILA-ATLDNTLKLWDYSKG 241 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 125/299 (41%), Gaps = 44/299 (14%) Query: 109 GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 G+ GK E I H+ ++ + + ++ + + + ++D + SG+C Sbjct: 68 GAYDGKFEKTIS-GHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVS--------SGKCL 117 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 L+GH + ++NP S ++S S D ++ +WD+ K H+ Sbjct: 118 K--TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDV-------KTGKCLKTLPAHSD 167 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V V ++ SL S + D IWDT S K +D V+ + F+P ++I Sbjct: 168 PVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPNGKYI 224 Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV--QWSPHNETILASSGTDRRLNVWD 346 LA + D T+ LWD K L ++ HK+E + + +S + S D + +W+ Sbjct: 225 LA-ATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 282 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQ 403 L E++ GHT + + +P E +I S + D +++W+ Sbjct: 283 LQT--------------KEIVQKLQGHTDVVISTACHPTE-NIIASAALENDKTIKLWK 326 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 39/155 (25%), Positives = 68/155 (43%), Gaps = 18/155 (11%) Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327 ++ HT V+ + F+P E+ LA+ SADK + +W + K + + HK I V WS Sbjct: 35 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS- 91 Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 387 + +L S+ D+ L +WD+S + L GH+ + ++NP + Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSG--------------KCLKTLKGHSNYVFCCNFNP-QS 136 Query: 388 WVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEG 422 +I S S D +++W + P S Sbjct: 137 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 171 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 23/47 (48%), Gaps = 1/47 (2%) Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 L F GHT +S ++PN W + S S D ++++W + + Sbjct: 32 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT 77 >6QX9-5O nrPDB Length = 357 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 60/238 (25%), Positives = 108/238 (45%), Gaps = 29/238 (12%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 P + L GH+ E Y ++PN S L SA D I LW++ D GH+ Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGD------CDNYATLKGHSG 110 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V ++ ++ LF S + D+ + +WD+ + + + HT+ VN + Sbjct: 111 AVMELHYNTDGSMLF-SASTDKTVAVWDSETG---ERVKRLKGHTSFVNSCYPARRGPQL 166 Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 348 + TGS D TV LWD+R K + +F++ ++ V ++ ++ I+ S G D + VWDL Sbjct: 167 VCTGSDDGTVKLWDIRK-KAAIQTFQN-TYQVLAVTFNDTSDQII-SGGIDNDIKVWDLR 223 Query: 349 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + +L + GH ++ S + +++ S + DN ++VW + Sbjct: 224 Q--------------NKLTYTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRP 266 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 122/305 (40%), Gaps = 34/305 (11%) Query: 117 IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGH 176 I + HEGEV ++ P N +A+ +L+++ G+C+ L+GH Sbjct: 59 IMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNV---------YGDCDNYATLKGH 108 Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 L +N + S L SAS D T+ +WD + + GHT+ V Sbjct: 109 SGAVMELHYNTDGS-MLFSASTDKTVAVWDSETGERVKR-------LKGHTSFVNSCYPA 160 Query: 237 LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK 296 L + +DD + +WD R + + T +V ++FN S+ I+ +G D Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQN----TYQVLAVTFNDTSDQII-SGGIDN 215 Query: 297 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 + +WDLR KL ++ H D + + S +L S+ D + VWD+ ++ Sbjct: 216 DIKVWDLRQNKL-TYTMRGHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERC 273 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN--IYNDEDP 414 G + SW+P+ I + S D + VW +Y Sbjct: 274 VKIFQGNVHNF------EKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGH 326 Query: 415 EGSVD 419 GS++ Sbjct: 327 AGSIN 331 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 76/189 (40%), Gaps = 21/189 (11%) Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 + +GH V +H + S S D+ +++W+ + ++ H+ V Sbjct: 58 PIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNV-YGDCDN-YATLKGHSGAVME 114 Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 338 L +N + + S DKTVA+WD + ++ + H + + ++ + Sbjct: 115 LHYNTDGSMLF-SASTDKTVAVWDSETGE-RVKRLKGHTSFVNSCYPARRGPQLVCTGSD 172 Query: 339 DRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 D + +WD+ K Q+ ++ T ++ ++N +I S DN Sbjct: 173 DGTVKLWDIRKKAAIQTFQN---------------TYQVLAVTFNDTSDQII-SGGIDND 216 Query: 399 MQVWQMAEN 407 ++VW + +N Sbjct: 217 IKVWDLRQN 225 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 63/151 (41%), Gaps = 16/151 (10%) Query: 257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 316 R ++ P + H EV C F+P LA+ D+ + LW++ + + H Sbjct: 50 PRCSSLQAPIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLKGH 108 Query: 317 KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 + ++ ++ ++L S+ TD+ + VWD + GHT+ Sbjct: 109 SGAVMELHYNTDG-SMLFSASTDKTVAVWDSETGERVKRL--------------KGHTSF 153 Query: 377 ISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 ++ P ++C+ S+D +++W + + Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKK 184 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 39/179 (21%), Positives = 78/179 (43%), Gaps = 24/179 (13%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 +V + + II + +D+ V+D ++ +RGH GLS Sbjct: 195 QVLAVTFNDTSDQII-SGGIDNDIKVWDLRQNKLTYT----------MRGHADSVTGLSL 243 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG--HT--AVVEDVSWHLLHES 241 + + +LLS + D+T+ +WD+ + + IF G H + SW Sbjct: 244 S-SEGSYLLSNAMDNTVRVWDVRPFAPKER---CVKIFQGNVHNFEKNLLRCSWSPDGSK 299 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + + + D+ + +WDT S + + + H +N ++F+P E I+ + S+DK + + Sbjct: 300 I-AAGSADRFVYVWDTTS---RRILYKLPGHAGSINEVAFHPD-EPIIISASSDKRLYM 353 >4BTS-AR nrPDB Length = 343 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 110/263 (41%), Gaps = 42/263 (15%) Query: 173 LRGHQKEGYGL--SWNPNL---SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 227 L GH + ++ S L+S S D T+ +W + + G TGH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 228 AVVEDVSWHLLHESLFG-SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286 V D++ E+ F S + D+ L +WD R+ T K H +EV ++F+P + Sbjct: 77 HFVSDLALS--QENCFAISSSWDKTLRLWDLRTGTTYK---RFVGHQSEVYSVAFSPDNR 131 Query: 287 FILATGSADKTVALWDL-RNLKLKLHSFESHKDEIFQVQWSPHNET---------ILASS 336 IL+ G A++ + LW++ K E+H D + V++SP ++ AS Sbjct: 132 QILSAG-AEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASV 190 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 G D RL VW+ + ++ + H + ++ S +PN + I + +D Sbjct: 191 GWDGRLKVWNTN---------------FQIRYTFKAHESNVNHLSISPNGKY-IATGGKD 234 Query: 397 NIMQVWQMAENIYNDEDPEGSVD 419 + +W + Y P+ D Sbjct: 235 KKLLIWDILNLTY----PQREFD 253 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 122/319 (38%), Gaps = 49/319 (15%) Query: 122 NHEGEVNRA-RYMPQNPC----IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGH 176 H V Q ++ + + V+++ + P L GH Sbjct: 19 GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQN---GYFGIPHKALTGH 75 Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 L+ + + +S+S D T+ LWD+ + F GH + V V++ Sbjct: 76 NHFVSDLALS-QENCFAISSSWDKTLRLWDL-------RTGTTYKRFVGHQSEVYSVAFS 127 Query: 237 LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE---------F 287 + + S ++++ +W+ S + H+ V+C+ ++P + Sbjct: 128 PDNRQIL-SAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAP 185 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 A+ D + +W+ ++F++H+ + + SP+ + +A+ G D++L +WD+ Sbjct: 186 YFASVGWDGRLKVWN--TNFQIRYTFKAHESNVNHLSISPNGK-YIATGGKDKKLLIWDI 242 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM--- 404 + Q DA + I+ ++NP WV +V D ++++ + Sbjct: 243 LNLTYPQREFDAG--------------STINQIAFNPKLQWV--AVGTDQGVKIFNLMTQ 286 Query: 405 AENIYNDEDPEGSVDPEGQ 423 ++ + E EGQ Sbjct: 287 SKAPVCTIEAEPITKAEGQ 305 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 41/263 (15%), Positives = 86/263 (32%), Gaps = 36/263 (13%) Query: 18 NEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDF---SIHRLVLGT---H 71 ++ ++W T Y + H E + + PD + +LG Sbjct: 97 DKTLRLWDLRTGTTYKRFVGHQSE--VYSVAFSPDNRQILSAGAEREIKLWNILGECKFS 154 Query: 72 TSDEQNH------LVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEI-EIKINHE 124 +++++NH + + + + Q A ++ S G G + +I HE Sbjct: 155 SAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFAS-VGWDGRLKVWNTNFQIRYTFKAHE 213 Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 VN P N IAT +L++D P ++ Sbjct: 214 SNVNHLSISP-NGKYIATGGKDKKLLIWDILNL---------TYPQREFDA-GSTINQIA 262 Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPK------EGKVVDAKTIFTGHTAVVEDVSWHLL 238 +NP L ++ D + ++++ K E + + G ++W+ L Sbjct: 263 FNPKL--QWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNAL 320 Query: 239 HESLFGSVADDQKLMIWDTRSNN 261 + LF D + + ++ Sbjct: 321 GKKLFAGFT-DGVIRTFSFETSA 342 >4V8M-A7 nrPDB Length = 318 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 130/314 (41%), Gaps = 47/314 (14%) Query: 119 IKINHEGEVNRARYMPQNPCI---IATKTPSSDVLVFDYTKHPSKPDPSGECN---PDLR 172 H G V PQ P + + + +L + P+ S EC+ PD R Sbjct: 8 QLTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSW----GPNPDRHSSECSYGLPDRR 62 Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH ++ + N +SAS DH++ LW++ + + F GHT V Sbjct: 63 LEGHSAFVSDVALS-NNGNFAVSASWDHSLRLWNL-------QNGQCQYKFLGHTKDVLS 114 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE-FILAT 291 V++ + + S D L +W+ + S AHT V+C+ F+P + ++ + Sbjct: 115 VAFSPDNRQIV-SGGRDNALRVWNVKGECMHTLSRG--AHTDWVSCVRFSPSLDAPVIVS 171 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 G D V +WDL +L + + H + + V SP ++ ASS D +WDL+K Sbjct: 172 GGWDNLVKVWDLATGRL-VTDLKGHTNYVTSVTVSPDG-SLCASSDKDGVARLWDLTKG- 228 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYND 411 ++ + G P I+ ++PN W+ + + ++++ + Sbjct: 229 --EALSEMAAGAP------------INQICFSPNRYWMCAATEKG--IRIFDLENK---- 268 Query: 412 EDPEGSVDPEGQGS 425 D + PE QGS Sbjct: 269 -DIIVELAPEHQGS 281 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 111/288 (38%), Gaps = 37/288 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V+ + N + + + +++ +G+C + GH K+ Sbjct: 65 GHSAFVSDVA-LSNNGNFAVSASWDHSLRLWNLQ--------NGQC--QYKFLGHTKDVL 113 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG-HTAVVEDVSWHL-LH 239 ++++P+ + ++S D+ + +W++ T+ G HT V V + L Sbjct: 114 SVAFSPD-NRQIVSGGRDNALRVWNVKGE-------CMHTLSRGAHTDWVSCVRFSPSLD 165 Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 + S D + +WD T + + HT V ++ +P + A+ D Sbjct: 166 APVIVSGGWDNLVKVWDL---ATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVAR 221 Query: 300 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 LWDL + I Q+ +SP+ + A T++ + ++DL Sbjct: 222 LWDLTKGEALSEMAAG--APINQICFSPNRYWMCA--ATEKGIRIFDLENKDIIVELAPE 277 Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 G +++ + +W+ + + S DN+++VW ++EN Sbjct: 278 HQGSKKIV-------PECVSIAWSADGST-LYSGYTDNVIRVWGVSEN 317 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 88/236 (37%), Gaps = 32/236 (13%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 + H +V + P N I+ + + + V++ GEC L H Sbjct: 106 LGHTKDVLSVAFSPDNRQIV-SGGRDNALRVWNV---------KGECMHTLSRGAHTDWV 155 Query: 181 YGLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 239 + ++P+L ++S D+ + +WD++ T GHT V V+ Sbjct: 156 SCVRFSPSLDAPVIVSGGWDNLVKVWDLATG-------RLVTDLKGHTNYVTSVTVSPDG 208 Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 L S D +WD + A +N + F+P ++ A +K + Sbjct: 209 S-LCASSDKDGVARLWDLTKGEALSEMAA----GAPINQICFSPNRYWMCAA--TEKGIR 261 Query: 300 LWDLRNLKLKLHSFESHKD------EIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 ++DL N + + H+ E + WS T L S TD + VW +S+ Sbjct: 262 IFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGST-LYSGYTDNVIRVWGVSE 316 >5NNZ-B nrPDB Length = 415 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 30/272 (11%) Query: 136 NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLS 195 P + A++T +L+ + + + L+ H ++ N ++ Sbjct: 52 EPLLTASRTEQVKLLIQRLQEKLGQNS-NHTFYLFKVLKAHILPLTNVALN-KSGSCFIT 109 Query: 196 ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW 255 S D T LWD ++ + GH VV ++++ + + + D+ +W Sbjct: 110 GSYDRTCKLWDTASGEE-------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162 Query: 256 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 + H+ HTAE+ CLSFNP ++ATGS D T LWD++N + ++++ Sbjct: 163 SVETGKCY---HTFRGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGE-EVYTLRG 217 Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375 H EI + ++ + I+ + D + VWD A+ G + I GH A Sbjct: 218 HSAEIISLSFNTSGDRII-TGSFDHTVVVWD------------ADTGRKVNILI--GHCA 262 Query: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 +IS S+N + +I + S D ++W Sbjct: 263 EISSASFNWDCS-LILTGSMDKTCKLWDATNG 293 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 40/292 (13%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 E+ H V + IAT + ++ +G+C RG Sbjct: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV--------ETGKCYH--TFRG 175 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H E LS+NP S + + S D T LWDI + GH+A + +S+ Sbjct: 176 HTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGEE-------VYTLRGHSAEIISLSF 227 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + + + + + D +++WD +T + + + H AE++ SFN IL TGS D Sbjct: 228 NTSGDRII-TGSFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMD 282 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 KT LWD N K + + H DEI + + ++A++ D ++ + Sbjct: 283 KTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGK-LIATASADGTARIFSAATR----- 335 Query: 356 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + + GH +IS S+NP ++ + S D ++W Sbjct: 336 ---------KCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTG 377 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 70/221 (31%), Gaps = 52/221 (23%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 E+ H E+ + II T + V+V+D L G Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKVN----------ILIG 259 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK-------------------- 215 H E S+N + S +L+ S D T LWD + Sbjct: 260 HCAEISSASFNWDCS-LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI 318 Query: 216 ---------------VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 260 GH + +S++ L + + D+ IWD ++ Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTG 377 Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 ++ HT E+ +FN Y I+ TGS D T +W Sbjct: 378 QC---LQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414 >5G04-R nrPDB Length = 499 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 111/293 (37%), Gaps = 31/293 (10%) Query: 93 FDASHYDS-----EKGEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIA 141 Y S ++G + G+ S ++++ + R + N I++ Sbjct: 223 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 282 Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + + S + D + L GH +E GL W P+ HL S +D+ Sbjct: 283 SGSRSGHIHHHDVR---------VAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNL 332 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA--DDQKLMIWDTRS 259 + +W + P EG V FT H V+ V+W ++ + D+ + IW+ S Sbjct: 333 VNVWP--SAPGEGGWV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 +VDAH+ + L Y E I G A + +W + K+ + H Sbjct: 390 GAC---LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSR 445 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + + SP T+ AS+ D L +W ++ + E + + IH G Sbjct: 446 VLSLTMSPDGATV-ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 118/302 (39%), Gaps = 43/302 (14%) Query: 110 SVSGKIEIEIKINHEGE-VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 + SG I +++ GE ++ ++ + +A T S++V ++D + Sbjct: 211 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDVQQQKRL-------- 261 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 + H LSWN S L S S I D+ +GH+ Sbjct: 262 --RNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEH------HVATLSGHSQ 310 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSFNPYSEF 287 V + W S +D + +W + P + H V +++ P+ Sbjct: 311 EVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 369 Query: 288 ILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLNV 344 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L + Sbjct: 370 VLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVI 427 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 W + + + GHT+++ + +P+ V S + D +++W+ Sbjct: 428 WKYPTMAK--------------VAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRC 472 Query: 405 AE 406 E Sbjct: 473 FE 474 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 93/224 (41%), Gaps = 28/224 (12%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W+ SG++L+ + D+++ LW S+ + + V+W + + Sbjct: 190 VDWS---SGNVLAVALDNSVYLWSASS-----GDILQLLQMEQPGEYISSVAW-IKEGNY 240 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 ++ +WD + K ++ +H+A V LS+N +IL++GS + D Sbjct: 241 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 294 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 +R + + + H E+ ++W+P LAS G D +NVW P +G Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 343 Query: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQM 404 L H + +W P + V+ + D +++W + Sbjct: 344 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 >4A11-B nrPDB Length = 408 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 101/253 (39%), Gaps = 17/253 (6%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG------HTAV 229 H L P ++LS D I L+D+ ++ G H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS--EF 287 VE V W+ +F S + D+ L +WDT + T+ + + V +P S Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEE----TVYSHHMSPVSTKHC 157 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 ++A G+ V L DL++ H + H+ EI V WSP + ILA++ D R+ +WD+ Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCS-HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 Query: 348 SKIGEEQSPEDAEDGPPELLFIH--GGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 + D +G H K++ + + ++ +V DN M++W + Sbjct: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWN-S 274 Query: 406 ENIYNDEDPEGSV 418 N N G V Sbjct: 275 SNGENTLVNYGKV 287 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 79/266 (29%), Gaps = 18/266 (6%) Query: 46 TAQWLP-DVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGE 104 T QW P D F V T+T + + + H G Sbjct: 104 TVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGT 163 Query: 105 FGGFGSVSGKIEIEI---KINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKP 161 G + H E+ + P+ I+AT + S V ++D + Sbjct: 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCL 223 Query: 162 DPSGECNPDLRL------RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 215 + N H + GL + + HLL+ D+ + LW+ S Sbjct: 224 ITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD-GLHLLTVGTDNRMRLWNSSNGE---N 279 Query: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 + ++ + S F V + ++ S + + H Sbjct: 280 TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSG---EQITMLKGHYKT 336 Query: 276 VNCLSFNPYSEFILATGSADKTVALW 301 V+C F + + +GS D + W Sbjct: 337 VDCCVFQSNFQELY-SGSRDCNILAW 361 >4GGA-A nrPDB Length = 420 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 111/293 (37%), Gaps = 31/293 (10%) Query: 93 FDASHYDS-----EKGEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIA 141 Y S ++G + G+ S ++++ + R + N I++ Sbjct: 144 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 203 Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + + S + D + L GH +E GL W P+ HL S +D+ Sbjct: 204 SGSRSGHIHHHDVR---------VAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNL 253 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA--DDQKLMIWDTRS 259 + +W + P EG V FT H V+ V+W ++ + D+ + IW+ S Sbjct: 254 VNVWP--SAPGEGGWV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 310 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 +VDAH+ + L Y E I G A + +W + K+ + H Sbjct: 311 GAC---LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSR 366 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + + SP T+ AS+ D L +W ++ + E + + IH G Sbjct: 367 VLSLTMSPDGATV-ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 418 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 119/302 (39%), Gaps = 43/302 (14%) Query: 110 SVSGKIEIEIKINHEGE-VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 + SG I +++ GE ++ ++ + +A T S++V ++D + Sbjct: 132 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDVQQQKRL-------- 182 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 + H LSWN S L S S I D+ +GH+ Sbjct: 183 --RNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEH------HVATLSGHSQ 231 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSFNPYSEF 287 V + W L S +D + +W + P + H V +++ P+ Sbjct: 232 EVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 290 Query: 288 ILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLNV 344 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L + Sbjct: 291 VLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVI 348 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 W + + + GHT+++ + +P+ V S + D +++W+ Sbjct: 349 WKYPTMAK--------------VAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRC 393 Query: 405 AE 406 E Sbjct: 394 FE 395 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 93/224 (41%), Gaps = 28/224 (12%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W+ SG++L+ + D+++ LW S+ + + V+W + + Sbjct: 111 VDWS---SGNVLAVALDNSVYLWSASS-----GDILQLLQMEQPGEYISSVAW-IKEGNY 161 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 ++ +WD + K ++ +H+A V LS+N +IL++GS + D Sbjct: 162 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 215 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 +R + + + H E+ ++W+P LAS G D +NVW P +G Sbjct: 216 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 264 Query: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQM 404 L H + +W P + V+ + D +++W + Sbjct: 265 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 308 >3FM0-A nrPDB Length = 345 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 121/281 (43%), Gaps = 22/281 (7%) Query: 132 YMPQNP--CIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNL 189 ++ NP ++A+ + ++ C L GHQ+ ++W+P Sbjct: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWI------CKSVLS-EGHQRTVRKVAWSP-C 72 Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 +L SAS D T C+W K + T GH V+ V+W +L + + D Sbjct: 73 GNYLASASFDATTCIWK-----KNQDDFECVTTLEGHENEVKSVAWAPSG-NLLATCSRD 126 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW-DLRNLKL 308 + + +W+ + + +++HT +V + ++P E +LA+ S D TV L+ + + + Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWV 185 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP--PEL 366 + E H+ ++ + + P + LAS DR + +W G EQ + P + Sbjct: 186 CCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + G H+ I D +W + + D+ ++V+Q N Sbjct: 245 CTLSGFHSRTIYDIAWC-QLTGALATACGDDAIRVFQEDPN 284 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 94/252 (37%), Gaps = 37/252 (14%) Query: 117 IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGH 176 + HE EV + P + ++AT + V V++ D E L H Sbjct: 98 VTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEV-------DEEDEYECVSVLNSH 149 Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 ++ + W+P+ L SAS D T+ L+ +E GH + V +++ Sbjct: 150 TQDVKHVVWHPSQE-LLASASYDDTVKLY-----REEEDDWVCCATLEGHESTVWSLAFD 203 Query: 237 LLHESLFGSVADDQKLMIW------DTRSNNTS------KPSHSVDA-HTAEVNCLSFNP 283 + L S +DD+ + IW + + S K ++ H+ + +++ Sbjct: 204 PSGQRL-ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262 Query: 284 YSEFILATGSADKTVALWDL--------RNLKLKLHSFESHKDEIFQVQWSPHNETILAS 335 + LAT D + ++ L H ++H ++ V W+P +LAS Sbjct: 263 LTG-ALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321 Query: 336 SGTDRRLNVWDL 347 D + W Sbjct: 322 CSDDGEVAFWKY 333 Score = 34.8 bits (78), Expect = 0.083, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 23/59 (38%), Gaps = 2/59 (3%) Query: 98 YDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 + + + S + H +VN + P+ P ++A+ + +V + Y + Sbjct: 279 FQEDPNSDPQQPTFSLTAHLHQA--HSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335 Score = 30.2 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 6/30 (20%), Positives = 14/30 (46%), Gaps = 1/30 (3%) Query: 380 FSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 +WNP ++ S D +++W + + Sbjct: 22 LAWNPAGT-LLASCGGDRRIRIWGTEGDSW 50 >5LCW-Q nrPDB Length = 374 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 111/293 (37%), Gaps = 31/293 (10%) Query: 93 FDASHYDS-----EKGEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIA 141 Y S ++G + G+ S ++++ + R + N I++ Sbjct: 98 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 157 Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + + S + D + L GH +E GL W P+ HL S +D+ Sbjct: 158 SGSRSGHIHHHDVR---------VAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNL 207 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA--DDQKLMIWDTRS 259 + +W + P EG V FT H V+ V+W ++ + D+ + IW+ S Sbjct: 208 VNVWP--SAPGEGGWV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 264 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 +VDAH+ + L Y E I G A + +W + K+ + H Sbjct: 265 GAC---LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSR 320 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + + SP T+ AS+ D L +W ++ + E + + IH G Sbjct: 321 VLSLTMSPDGATV-ASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 372 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 119/302 (39%), Gaps = 43/302 (14%) Query: 110 SVSGKIEIEIKINHEGE-VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 + SG I +++ GE ++ ++ + +A T S++V ++D + Sbjct: 86 ASSGDILQLLQMEQPGEYISSVAWI-KEGNYLAVGTSSAEVQLWDVQQQKRL-------- 136 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 + H LSWN S L S S I D+ +GH+ Sbjct: 137 --RNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEH------HVATLSGHSQ 185 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSFNPYSEF 287 V + W L S +D + +W + P + H V +++ P+ Sbjct: 186 EVCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSN 244 Query: 288 ILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLNV 344 +LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L + Sbjct: 245 VLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVI 302 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 W + + + GHT+++ + +P+ V S + D +++W+ Sbjct: 303 WKYPTMAK--------------VAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRC 347 Query: 405 AE 406 E Sbjct: 348 FE 349 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 93/224 (41%), Gaps = 28/224 (12%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W+ SG++L+ + D+++ LW S+ + + V+W + + Sbjct: 65 VDWS---SGNVLAVALDNSVYLWSASS-----GDILQLLQMEQPGEYISSVAW-IKEGNY 115 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 ++ +WD + K ++ +H+A V LS+N +IL++GS + D Sbjct: 116 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 169 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 +R + + + H E+ ++W+P LAS G D +NVW P +G Sbjct: 170 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 218 Query: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQM 404 L H + +W P + V+ + D +++W + Sbjct: 219 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 262 >1VYH-C nrPDB Length = 410 Score = 168 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 116/313 (37%), Gaps = 60/313 (19%) Query: 112 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 +G E +K H V + + ++A+ + + ++D+ EC Sbjct: 139 TGDFERTLK-GHTDSVQDISF-DHSGKLLASCSADMTIKLWDFQ--------GFEC--IR 186 Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 + GH +S PN H++SAS D TI +W++ + FTGH V Sbjct: 187 TMHGHDHNVSSVSIMPN-GDHIVSASRDKTIKMWEV-------QTGYCVKTFTGHREWVR 238 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF---- 287 V + L S ++DQ + +W T + + H V C+S+ P S + Sbjct: 239 MVRPNQDGT-LIASCSNDQTVRVW---VVATKECKAELREHRHVVECISWAPESSYSSIS 294 Query: 288 ---------------ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 332 L +GS DKT+ +WD+ + L + H + + V + Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG-MCLMTLVGHDNWVRGVLFH-SGGKF 352 Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 + S D+ L VWD + H ++ ++ P+V+ + Sbjct: 353 ILSCADDKTLRVWDYKN--------------KRCMKTLNAHEHFVTSLDFHKTAPYVV-T 397 Query: 393 VSEDNIMQVWQMA 405 S D ++VW+ Sbjct: 398 GSVDQTVKVWECR 410 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 107/241 (44%), Gaps = 20/241 (8%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH+ + ++P S ++SAS+D TI +WD D + GHT V+D Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETG-------DFERTLKGHTDSVQD 155 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +S+ L S + D + +WD + + H H V+ +S P + I+ + Sbjct: 156 ISF-DHSGKLLASCSADMTIKLWDFQGFECIRTMH---GHDHNVSSVSIMPNGDHIV-SA 210 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S DKT+ +W+++ + +F H++ + V+ + T++AS D+ + VW ++ Sbjct: 211 SRDKTIKMWEVQTGYC-VKTFTGHREWVRMVRPNQDG-TLIASCSNDQTVRVWVVATKEC 268 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP-----WVICSVSEDNIMQVWQMAEN 407 + + + + + IS+ + + + + S S D +++W ++ Sbjct: 269 KAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328 Query: 408 I 408 + Sbjct: 329 M 329 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 107/307 (34%), Gaps = 59/307 (19%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 E H V R + P ++ + + + + V+DY + L+G Sbjct: 100 EKYALSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDF----------ERTLKG 148 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H +S++ + L S S D TI LWD + GH V VS Sbjct: 149 HTDSVQDISFD-HSGKLLASCSADMTIKLWDFQG-------FECIRTMHGHDHNVSSVSI 200 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + + S + D+ + +W+ ++ K + H V + N I A+ S D Sbjct: 201 MPNGDHIV-SASRDKTIKMWEVQTGYCVK---TFTGHREWVRMVRPNQDGTLI-ASCSND 255 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-------------------ILASS 336 +TV +W + + K H+ + + W+P + L S Sbjct: 256 QTVRVWVVATKECK-AELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSG 314 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D+ + +WD+S L GH + ++ +++ S ++D Sbjct: 315 SRDKTIKMWDVSTG--------------MCLMTLVGHDNWVRGVLFHSGGKFIL-SCADD 359 Query: 397 NIMQVWQ 403 ++VW Sbjct: 360 KTLRVWD 366 >5FL8-q nrPDB Length = 515 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 123/337 (36%), Gaps = 81/337 (24%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V + P + +IAT + + + ++D SG+C D LRGH K Sbjct: 184 GHYNWVLCVSWSP-DGEVIATGSMDNTIRLWD--------PKSGQCLGDA-LRGHSKWIT 233 Query: 182 GLSW------NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 LSW P L S+S D TI +WD + + +GHT V V W Sbjct: 234 SLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRV-------CQYTMSGHTNSVSCVKW 286 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF-------------- 281 + L S + D+ + +WD N+ + + + +H VN LS Sbjct: 287 --GGQGLLYSGSHDRTVRVWDI--NSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHT 342 Query: 282 ------------------------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317 N SE ++ T S D T+ LW+ + H+ Sbjct: 343 GKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQ 402 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 + V +SP I+ S+ D + +WD + + GH A + Sbjct: 403 KLVNHVAFSPDGRYIV-SASFDNSIKLWDGRDG--------------KFISTFRGHVASV 447 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 +W+ + ++ S S+D ++VW + + + P Sbjct: 448 YQVAWSSDCR-LLVSCSKDTTLKVWDVRTRKLSVDLP 483 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 123/326 (37%), Gaps = 80/326 (24%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H + + + P + T + ++D P L+GH Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWD----------CDTQTPMHTLKGHYNWVL 190 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH-- 239 +SW+P+ + + S D+TI LWD PK G+ + GH+ + +SW +H Sbjct: 191 CVSWSPD-GEVIATGSMDNTIRLWD----PKSGQCL--GDALRGHSKWITSLSWEPIHLV 243 Query: 240 ----ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + S + D + IWDT S +++ HT V+C+ + + +L +GS D Sbjct: 244 KPGSKPRLASSSKDGTIKIWDTVSRVC---QYTMSGHTNSVSCVKW--GGQGLLYSGSHD 298 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH--------------------------- 328 +TV +WD+ + ++ +SH + + S Sbjct: 299 RTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALE 358 Query: 329 -----------NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 +E ++ ++ D + +W+ K + + GH + Sbjct: 359 NYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKP-------------IARMTGHQKLV 405 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQ 403 + +++P+ +++ S S DN +++W Sbjct: 406 NHVAFSPDGRYIV-SASFDNSIKLWD 430 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 52/267 (19%), Positives = 99/267 (37%), Gaps = 44/267 (16%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 + GH ++ P+ S +++ + D+T +WD GH V Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQ-------TPMHTLKGHYNWVLC 191 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY------SE 286 VSW E + + + D + +WD +S ++ H+ + LS+ P S+ Sbjct: 192 VSWSPDGE-VIATGSMDNTIRLWDPKSGQCL--GDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 LA+ S D T+ +WD + + ++ H + + V+W + +L S DR + VWD Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQ-YTMSGHTNSVSCVKW--GGQGLLYSGSHDRTVRVWD 305 Query: 347 LSKIGEEQSPEDAEDGPPELL------------FIHGGHTAKISD-------------FS 381 ++ G + + L F H G + Sbjct: 306 INSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICK 365 Query: 382 WNPNEPWVICSVSEDNIMQVWQMAENI 408 N N ++ + S+D M +W ++ Sbjct: 366 KNGNSEEMMVTASDDYTMFLWNPLKST 392 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 53/215 (24%), Positives = 89/215 (41%), Gaps = 26/215 (12%) Query: 196 ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW 255 +++D L+ AV K V + + GH + + ++ S + A D IW Sbjct: 112 STEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIW 171 Query: 256 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 D +T P H++ H V C+S++P E ++ATGS D T+ LWD ++ + + Sbjct: 172 D---CDTQTPMHTLKGHYNWVLCVSWSPDGE-VIATGSMDNTIRLWDPKSGQCLGDALRG 227 Query: 316 HKDEIFQVQWSPHN------ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 H I + W P + + LASS D + +WD + Sbjct: 228 HSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWD--------------TVSRVCQYT 273 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 GHT +S W ++ S S D ++VW + Sbjct: 274 MSGHTNSVSCVKW--GGQGLLYSGSHDRTVRVWDI 306 Score = 117 bits (293), Expect = 9e-27, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 93/266 (34%), Gaps = 61/266 (22%) Query: 119 IKINHEGEVNRARYMPQNPC-IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQ 177 + G N + ++ + + V V+D + L+ H Sbjct: 270 CQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCIN---------ILKSHA 320 Query: 178 KEGYGLSW--------------------------------------NPNLSGHLLSASDD 199 LS N N +++ASDD Sbjct: 321 HWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDD 380 Query: 200 HTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS 259 +T+ LW+ K TGH +V V++ + S + D + +WD R Sbjct: 381 YTMFLWN------PLKSTKPIARMTGHQKLVNHVAFSPDGRYIV-SASFDNSIKLWDGRD 433 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 K + H A V ++++ +L + S D T+ +WD+R KL + HKDE Sbjct: 434 G---KFISTFRGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWDVRTRKLSV-DLPGHKDE 488 Query: 320 IFQVQWSPHNETILASSGTDRRLNVW 345 ++ V WS + + S G D+ + +W Sbjct: 489 VYTVDWSVDGKRVC-SGGKDKMVRLW 513 >5OPT-p nrPDB Length = 318 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 123/300 (41%), Gaps = 37/300 (12%) Query: 122 NHEGEVNRARYMPQNPCI---IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 H G V PQ + + + ++ + + + P+ RL GH Sbjct: 11 GHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWG-SNMDRNSEECEYGFPERRLEGHSA 68 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 ++ + N +SAS DH++ LW++ + + F GHT V V++ Sbjct: 69 FVSDVALS-NNGDFAVSASWDHSLRLWNL-------QTGVCQHKFLGHTKDVLSVTFSPD 120 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY-SEFILATGSADKT 297 + + S D L +W+ + AHT V+C+ F+P ++ +G D Sbjct: 121 NRQIV-SGGRDNALRVWNVKGECLHTLGRG--AHTDWVSCVRFSPSLETPLIVSGGWDNL 177 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE 357 V +WD+ + +L L + H + I V SP ++ ASS D +WDL+K ++ Sbjct: 178 VKVWDIASGRL-LTDLKGHTNYITSVTVSPDG-SLCASSDKDGVARLWDLTKG---EALS 232 Query: 358 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA-ENIYNDEDPEG 416 + G P I+ ++PN W+ + + ++++ + +++ + PE Sbjct: 233 EMAAGAP------------INQICFSPNRYWMCAATEKG--IRIFDLENKDVIVELAPEA 278 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 56/251 (22%), Positives = 111/251 (44%), Gaps = 25/251 (9%) Query: 172 RLRGHQKEGYGLSWNPNLSGHL--LSASDDHTICLW--DISAVPKEGKVVDAKTIFTGHT 227 +L+GH+ L+ ++ +S S D+T+ W ++ +E + + GH+ Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 A V DV+ + S + D L +W+ ++ H HT +V ++F+P + Sbjct: 68 AFVSDVALSN-NGDFAVSASWDHSLRLWNLQTGVC---QHKFLGHTKDVLSVTFSPDNRQ 123 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET-ILASSGTDRRLNVWD 346 I+ +G D + +W+++ L +H D + V++SP ET ++ S G D + VWD Sbjct: 124 IV-SGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 ++ LL GHT I+ + +P+ + S +D + ++W + + Sbjct: 183 IASG--------------RLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLWDLTK 227 Query: 407 NIYNDEDPEGS 417 E G+ Sbjct: 228 GEALSEMAAGA 238 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 50/236 (21%), Positives = 88/236 (37%), Gaps = 32/236 (13%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 + H +V + P N I+ + + + V++ GEC L H Sbjct: 106 LGHTKDVLSVTFSPDNRQIV-SGGRDNALRVWNV---------KGECLHTLGRGAHTDWV 155 Query: 181 YGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 239 + ++P+L L+ S D+ + +WDI++ T GHT + V+ Sbjct: 156 SCVRFSPSLETPLIVSGGWDNLVKVWDIASG-------RLLTDLKGHTNYITSVTVSPDG 208 Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 SL S D +WD + A +N + F+P ++ A +K + Sbjct: 209 -SLCASSDKDGVARLWDLTKGEALSEMAA----GAPINQICFSPNRYWMCAA--TEKGIR 261 Query: 300 LWDLRNLKLKL------HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 ++DL N + + E + WS T L S TD + VW +S+ Sbjct: 262 IFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT-LYSGYTDNVIRVWSVSE 316 >4V7E-Bg nrPDB Length = 380 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 117/286 (40%), Gaps = 27/286 (9%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H V + P N +A S +F+ + S+ D G L GH+ Sbjct: 107 HCPWVMECAFAP-NGQSVACGGLDSACSIFNLS---SQADRDGNMPVSRVLTGHKGYASS 162 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + P+ L++ S D T LWD++ + + +GHTA V +S + L+ ++ Sbjct: 163 CQYVPDQETRLITGSGDQTCVLWDVTTGQRIS--IFGSEFPSGHTADVLSLSINSLNANM 220 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 F S + D + +WD R TS+ + H ++N + F P + TGS D T L+D Sbjct: 221 FISGSCDTTVRLWDLRI--TSRAVRTYHGHEGDINSVKFFPDGQ-RFGTGSDDGTCRLFD 277 Query: 303 LRNL-KLKLHSFESHKDE-----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 +R +L++++ E +++ + V +S + A VWD + Sbjct: 278 MRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSN-GDCYVWDTLLAEMVLNL 336 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 ++ H +IS + + +C+ S D +++W Sbjct: 337 GTLQNS----------HEGRISCLGLSSDGS-ALCTGSWDKNLKIW 371 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 53/314 (16%), Positives = 111/314 (35%), Gaps = 23/314 (7%) Query: 94 DASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFD 153 D Y +G + + + H G+V + P+ I + + ++V+ Sbjct: 36 DVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEK-NWIVSASQDGRLIVW- 93 Query: 154 YTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKE 213 + + ++L H ++ PN + D ++++S+ Sbjct: 94 -------NALTSQKTHAIKL--HCPWVMECAFAPN-GQSVACGGLDSACSIFNLSSQADR 143 Query: 214 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKP--SHSVDA 271 + + TGH + E+ + + DQ ++WD + S Sbjct: 144 DGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSG 203 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 331 HTA+V LS N + + +GS D TV LWDLR + ++ H+ +I V++ P + Sbjct: 204 HTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQR 263 Query: 332 ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC 391 + D ++D+ + Q D L ++ +++ + + Sbjct: 264 -FGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNEL-------PIVTSVAFSISGRLLFA 315 Query: 392 SVSEDNIMQVWQMA 405 S + VW Sbjct: 316 GYS-NGDCYVWDTL 328 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 42/152 (27%), Gaps = 61/152 (40%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTK------HPSKPDPSGECNPD----- 170 HEG++N ++ P + T + +FD + +PD + P Sbjct: 247 GHEGDINSVKFFP-DGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVA 305 Query: 171 ------LRLRG--------------------------HQKEGYGLSWNPNLSGHLLSASD 198 L G H+ L + + S L + S Sbjct: 306 FSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSA-LCTGSW 364 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 D + +W F+GH +V Sbjct: 365 DKNLKIW----------------AFSGHRKIV 380 >6QX9-4B nrPDB Length = 522 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 106/288 (36%), Gaps = 46/288 (15%) Query: 122 NHEGEVNRARYMPQ-------NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR 174 H V + P+ +A+ V ++ P + Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDE----------PVADIE 320 Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + W+P+ L + D + LWD+ A + GH+ V D++ Sbjct: 321 GHTVRVARVMWHPS-GRFLGTTCYDRSWRLWDLEAQEEILHQ-------EGHSMGVYDIA 372 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 +H L G+ D +WD R+ + ++ H E+ ++F+P + +ATGS Sbjct: 373 FHQDGS-LAGTGGLDAFGRVWDLRTG---RCIMFLEGHLKEIYGINFSPNG-YHIATGSG 427 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 D T +WDLR + +++ +H++ + V++ P + L + D +W Sbjct: 428 DNTCKVWDLRQRRC-VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW--------- 477 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 L GH K+ + + +I + S D ++W Sbjct: 478 -----THPGWSPLKTLAGHEGKVMGLDISSDGQ-LIATCSYDRTFKLW 519 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 120/337 (35%), Gaps = 51/337 (15%) Query: 79 LVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIE----IEIKINHEGEVNRARYMP 134 L IA+ LP + + + E E + + + + G+ Y Sbjct: 179 LWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCH 238 Query: 135 QNPC--IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN---- 188 +P ++AT S ++ PD CN LRGH + ++P Sbjct: 239 FSPNSKMLATACWSGLCKLWSV------PD----CNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 189 ---LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 +L S + D ++ LW + + + GHT V V WH G+ Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSD-------EPVADIEGHTVRVARVMWHPSGR-FLGT 340 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 D+ +WD + + + H+ V ++F+ + TG D +WDLR Sbjct: 341 TCYDRSWRLWDLEAQ---EEILHQEGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRT 396 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 + + E H EI+ + +SP+ +A+ D VWDL + Sbjct: 397 GRC-IMFLEGHLKEIYGINFSPNG-YHIATGSGDNTCKVWDLRQR--------------R 440 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 ++ H ++ + P + + + DN ++W Sbjct: 441 CVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 90/255 (35%), Gaps = 36/255 (14%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 G + ++PN S L +A LW + GH V + Sbjct: 229 GDDRPISYCHFSPN-SKMLATACWSGLCKLWSVPDCN-------LLHTLRGHNTNVGAIV 280 Query: 235 WHL-------LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 +H + S A D + +W S ++ +P ++ HT V + ++P F Sbjct: 281 FHPKSTVSLDPKDVNLASCAADGSVKLW---SLDSDEPVADIEGHTVRVARVMWHPSGRF 337 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 L T D++ LWDL + LH E H ++ + + ++ + G D VWDL Sbjct: 338 -LGTTCYDRSWRLWDLEAQEEILHQ-EGHSMGVYDIAFHQDG-SLAGTGGLDAFGRVWDL 394 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + GH +I +++PN I + S DN +VW + + Sbjct: 395 RTG--------------RCIMFLEGHLKEIYGINFSPNGYH-IATGSGDNTCKVWDLRQR 439 Query: 408 IYNDEDPEGSVDPEG 422 P G Sbjct: 440 RCVYTIPAHQNLVTG 454 >3W15-A nrPDB Length = 368 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 117/308 (37%), Gaps = 42/308 (13%) Query: 129 RARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN 188 + + + + +FD T + P + H++E + +WN Sbjct: 67 DLAWNESHENQVLVAQGDGTLRLFDTT---------FKEFPIAIFKEHEREVFSCNWNLV 117 Query: 189 LSGHLLSASDDHTICLWD-------ISAVPKEGKV----------VDAKTIFTG---HTA 228 + LS+S D +I +W ++ P+ ++ + K FTG + Sbjct: 118 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 177 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 V + ++L S + + ++D R + ++ + E FN Y ++ Sbjct: 178 CVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYV 237 Query: 289 LATGSADKTVALWDLR----------NLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 338 +ATG D + +WD+R N +H I +V WSPH+ IL S+ Sbjct: 238 VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 297 Query: 339 DRRLNVW-DLSKIG-EEQSPEDAEDGPPELLFIHGGHTAKISDFSWN-PNEPWVICSVSE 395 D +W DLS G +E ++ D +F H+ + W+ +P + S + Sbjct: 298 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 357 Query: 396 DNIMQVWQ 403 D + VW Sbjct: 358 DGNLFVWN 365 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 62/323 (19%), Positives = 117/323 (36%), Gaps = 36/323 (11%) Query: 129 RARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN 188 +Y P +A S+ LV + + D SG Q + L+WN + Sbjct: 15 GVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFL-TQDCLFDLAWNES 73 Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 248 +L A D T+ L+D + IF H V +W+L++ F S + Sbjct: 74 HENQVLVAQGDGTLRLFDTTFKE------FPIAIFKEHEREVFSCNWNLVNRQNFLSSSW 127 Query: 249 DQKLMIWDTRSNNTSKPS---------------------HSVDAHTAEVNCL---SFNPY 284 D + IW + S + NC+ F+P+ Sbjct: 128 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 187 Query: 285 SEFILATGSADKTVALWDLRNLKLK-LHSFESHKD-EIFQVQWSPHNETILASSGTDRRL 342 + ++ + S + +L+D+R K ++F H E ++ + ++A+ G D + Sbjct: 188 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 247 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 +WD+ + + E I H I +W+P+ ++ S S D ++W Sbjct: 248 RIWDIRMLNKNPGQLHNSSCINE---IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 304 Query: 403 QMAENIYNDEDPEGSVDPEGQGS 425 + N E + + +GS Sbjct: 305 RDLSNDGAKETYKTNSTDATKGS 327 Score = 91.4 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 50/267 (18%), Positives = 92/267 (34%), Gaps = 47/267 (17%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFD-------YTKHPSKPDPSGECNP----- 169 HE EV + N + + + ++ T P + + +P Sbjct: 104 EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAII 163 Query: 170 --DLRLRGHQKE---GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 224 G K Y ++P+ +LS S + L+DI + F Sbjct: 164 LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS-----GKNQNNFL 218 Query: 225 GHTA-VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-------KPSHSV-DAHTAE 275 H+ ++ + + D + IWD R N + + + +AH Sbjct: 219 VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLA 278 Query: 276 VNCLSFNPYSEFILATGSADKTVALW-DLRNLKLK--------------LHSFESHKDEI 320 + ++++P+ IL + S D T +W DL N K + +F H + + Sbjct: 279 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 338 Query: 321 FQVQWSPHNE-TILASSGTDRRLNVWD 346 F WS + +AS+ D L VW+ Sbjct: 339 FGADWSLWGKPGYVASTAWDGNLFVWN 365 >3JRO-A nrPDB Length = 753 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 108/299 (36%), Gaps = 47/299 (15%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW-NPNLSGHLLSASD 198 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 75 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH-ESLFGSVADDQKLMIWDT 257 D + +W +E + H+A V V W L + D K+ + + Sbjct: 76 DGKVLIWK-----EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 305 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 131 KENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 306 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + E H D + V WSP + LAS DR +W +D E Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 239 Query: 361 DGPPELLFIHGGHTAKISD-FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 GP + + + SW+ + V+ DN + +W+ EN+ +P G V Sbjct: 240 QGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTLWK--ENLEGKWEPAGEV 295 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 96/266 (36%), Gaps = 35/266 (13%) Query: 117 IEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 I+ HEG V R + P+ I+A+ + VL++ + +G + Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 97 Query: 176 HQKEGYGLSWNPN-LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 H + W P+ LL AS D + + + KE I H V S Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF----KENGTTSPI-IIDAHAIGVNSAS 152 Query: 235 WHLL------------HESLFGSVADDQKLMIWDTRS-NNTSKPSHSVDAHTAEVNCLSF 281 W F + D + IW S T +++ H+ V +++ Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 Query: 282 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHK--DEIFQVQWSPHNETILAS 335 +P LA+ S D+T +W D K + K D +++ WS +LA Sbjct: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 271 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAED 361 SG D ++ +W + G+ + + Sbjct: 272 SGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 84/231 (36%), Gaps = 33/231 (14%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVA 247 L + S D TI ++++ EG+ TGH V V W H ++ S + Sbjct: 20 YGKRLATCSSDKTIKIFEV-----EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLR-N 305 D K++IW N H+A VN + + P+ +L S+D V++ + + N Sbjct: 75 YDGKVLIW-KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 133 Query: 306 LKLKLHSFESHKDEIFQVQWSP------------HNETILASSGTDRRLNVWDLSKIGEE 353 ++H + W+P + G D + +W + + Sbjct: 134 GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVW 402 E GH+ + D +W+P + SVS+D +W Sbjct: 194 YVLES----------TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 >5GAN-H nrPDB Length = 465 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 110/300 (36%), Gaps = 52/300 (17%) Query: 136 NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLS 195 + ++AT + + D+ V + P + +L H + + W+P+ + ++S Sbjct: 186 DDMVVATGSWAGDLQV----LNSQTLQPLTQ-----KLDSHVGKIGAIDWHPDSNNQMIS 236 Query: 196 ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW 255 ++D I + S +EG + GH + DV +H GS + D +W Sbjct: 237 CAEDGLIKNFQYS--NEEGG-LRLLGDLVGHERRISDVKYHPSG-KFIGSASHDMTWRLW 292 Query: 256 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 D +T + + H V LSF ++ +G D LWD+R+ K+ + Sbjct: 293 DA---STHQELLLQEGHDKGVFSLSFQCDGS-LVCSGGMDSLSMLWDIRSGS-KVMTLAG 347 Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ--------------------- 354 H I+ V WSP+ + A+ G D +NVWD+ K E Q Sbjct: 348 HSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDG 406 Query: 355 -----------SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + GHT KI + N + S D +++W Sbjct: 407 GKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 98/261 (37%), Gaps = 24/261 (9%) Query: 87 PNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPS 146 P+ + Q + D F G + + HE ++ +Y P + I + + Sbjct: 228 PDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP-SGKFIGSASHD 286 Query: 147 SDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD 206 ++D + H L GH K + LS+ + S + S D LWD Sbjct: 287 MTWRLWDASTH----------QELLLQEGHDKGVFSLSFQCDGS-LVCSGGMDSLSMLWD 335 Query: 207 ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 I + K GH+ + V+W + + D + +WD R + + + Sbjct: 336 IRSGSK-------VMTLAGHSKPIYTVAWSP-NGYQVATGGGDGIINVWDIRKRDEGQLN 387 Query: 267 HSVDAHTAEVNCLSFNP-YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 325 + AH V + F+ L + D + ++ + LK+ S H D+I + Sbjct: 388 QIL-AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS-SDTWLKMGSLAGHTDKIISLDI 445 Query: 326 SPHNETILASSGTDRRLNVWD 346 S +N L S G DR + +W+ Sbjct: 446 S-NNSHFLVSGGWDRSIKLWN 465 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 83/233 (35%), Gaps = 28/233 (12%) Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT-IFTGHTAVVEDVSW 235 K +S + + + + S W + + T H + + W Sbjct: 175 TKPISAVSLSTDDM-VVATGS-------WAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDW 226 Query: 236 HLLHESLFGSVADDQKLMIWDT-RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 H + S A+D + + + + H ++ + ++P +FI + S Sbjct: 227 HPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFI-GSASH 285 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 D T LWD + +L E H +F + + + +++ S G D +WD+ + Sbjct: 286 DMTWRLWD-ASTHQELLLQEGHDKGVFSLSF-QCDGSLVCSGGMDSLSMLWDIRSGSKVM 343 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + GH+ I +W+PN V + D I+ VW + + Sbjct: 344 TL--------------AGHSKPIYTVAWSPNGYQV-ATGGGDGIINVWDIRKR 381 >6ID0-T nrPDB Length = 514 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 108/299 (36%), Gaps = 44/299 (14%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H G V P N + T + + ++D K L L GH Sbjct: 202 GHLGWVRCIAVEPGNQWFV-TGSADRTIKIWDLASGKLK----------LSLTGHISTVR 250 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 G+ + S +L S +D + WD+ + GH + V + H + Sbjct: 251 GVIVS-TRSPYLFSCGEDKQVKCWDLE-------YNKVIRHYHGHLSAVYGLDLHPTID- 301 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 + + + D IWD R T H++ HT V + I+ TGS D T+ LW Sbjct: 302 VLVTCSRDSTARIWDVR---TKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLW 357 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 DL K ++ + +HK + V P + T AS D + W Q+ Sbjct: 358 DLVAGKTRV-TLTNHKKSVRAVVLHPRHYT-FASGSPDN-IKQWKFPDGSFIQNL----- 409 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420 GH A I+ + N + V+ S +++ M +W YN + +V P Sbjct: 410 ---------SGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTG-YNFQRVHAAVQP 456 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 35/144 (24%), Positives = 64/144 (44%), Gaps = 18/144 (12%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 K + H V C++ P +++ TGSAD+T+ +WDL + KLKL S H + V Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLASGKLKL-SLTGHISTVRGV 252 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 S + + S G D+++ WDL +++ + GH + + + Sbjct: 253 IVSTRSPYLF-SCGEDKQVKCWDLE--------------YNKVIRHYHGHLSAVYGLDLH 297 Query: 384 PNEPWVICSVSEDNIMQVWQMAEN 407 P V+ + S D+ ++W + Sbjct: 298 PTI-DVLVTCSRDSTARIWDVRTK 320 >6HHQ-h nrPDB Length = 319 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 103/238 (43%), Gaps = 29/238 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH L+ + LLSAS D T+ W ++ ++ V F GH+ +V+D Sbjct: 13 LEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGV--PVRSFKGHSHIVQD 70 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + S + D+ L +WD + T + H ++V + + + I+ +G Sbjct: 71 CTLTADGAYAL-SASWDKTLRLWDVATGETYQ---RFVGHKSDVMSVDIDKKASMII-SG 125 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP-----HNETILASSGTDRRLNVWDL 347 S DKT+ +W ++ L + H D + QV+ P + + S+G D+ + W+L Sbjct: 126 SRDKTIKVWTIKGQC--LATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL 183 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 ++ ++ GH + I+ + +P+ +I S +D + +W +A Sbjct: 184 NQF--------------QIEADFIGHNSNINTLTASPDGT-LIASAGKDGEIMLWNLA 226 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 109/324 (33%), Gaps = 60/324 (18%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H G V P ++ + + ++ + T D P +GH Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTG-----DDQKFGVPVRSFKGHSHIVQ 69 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + LSAS D T+ LWD++ + F GH + V V S Sbjct: 70 DCTLTAD-GAYALSASWDKTLRLWDVATG-------ETYQRFVGHKSDVMSVDI-DKKAS 120 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-----EFILATGSADK 296 + S + D+ + +W + + ++ H V+ + P + + DK Sbjct: 121 MIISGSRDKTIKVWTIK----GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDK 176 Query: 297 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS-------- 348 V W+L +++ F H I + SP T++AS+G D + +W+L+ Sbjct: 177 MVKAWNLNQFQIE-ADFIGHNSNINTLTASPDG-TLIASAGKDGEIMLWNLAAKKAMYTL 234 Query: 349 --------------------------KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 K+ +D PE +W Sbjct: 235 SAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAW 294 Query: 383 NPNEPWVICSVSEDNIMQVWQMAE 406 + + + + DN+++VWQ+ Sbjct: 295 SADGQTLFAGYT-DNVIRVWQVMT 317 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 40/96 (41%), Gaps = 10/96 (10%) Query: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371 + E H + + S +L S+ D+ L W L+ +D + G P F Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTG-------DDQKFGVPVRSF--K 62 Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 GH+ + D + + + + S S D +++W +A Sbjct: 63 GHSHIVQDCTLTADGAYAL-SASWDKTLRLWDVATG 97 Score = 36.7 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 20/50 (40%) Query: 369 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 GH ++ + + +P ++ S S D + W++ + P S Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSF 61 >4N14-A nrPDB Length = 314 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 104/273 (38%), Gaps = 31/273 (11%) Query: 93 FDASHYDS-----EKGEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIA 141 Y S ++G + G+ S ++++ + R + N I++ Sbjct: 60 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILS 119 Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + + S + D + L GH +E GL W P+ HL S +D+ Sbjct: 120 SGSRSGHIHHHDVR---------VAEHHVATLSGHSQEVCGLRWAPD-GRHLASGGNDNL 169 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVA--DDQKLMIWDTRS 259 + +W + P EG V FT H V+ V+W ++ + D+ + IW+ S Sbjct: 170 VNVWP--SAPGEGGWV-PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 226 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 +VDAH+ + L Y E I G A + +W + K+ + H Sbjct: 227 GAC---LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA-KVAELKGHTSR 282 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 + + SP T+ AS+ D L +W ++ Sbjct: 283 VLSLTMSPDGATV-ASAAADETLRLWRCFELDP 314 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 57/301 (18%), Positives = 116/301 (38%), Gaps = 41/301 (13%) Query: 110 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP 169 + SG I +++ GE + + +A T S++V ++D + Sbjct: 48 ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRL--------- 98 Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 229 + H LSWN S L S S I D+ +GH+ Sbjct: 99 -RNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHDVRVAEH------HVATLSGHSQE 148 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSFNPYSEFI 288 V + W L S +D + +W + P + H V +++ P+ + Sbjct: 149 VCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 207 Query: 289 LATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLNVW 345 LATG +D+ + +W++ + L + ++H + + WSPH + +++ G +L +W Sbjct: 208 LATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIW 265 Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 + + + GHT+++ + +P+ V S + D +++W+ Sbjct: 266 KYPTMAK--------------VAELKGHTSRVLSLTMSPDGATV-ASAAADETLRLWRCF 310 Query: 406 E 406 E Sbjct: 311 E 311 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 93/224 (41%), Gaps = 28/224 (12%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W+ SG++L+ + D+++ LW S+ + + V+W + + Sbjct: 27 VDWS---SGNVLAVALDNSVYLWSASS-----GDILQLLQMEQPGEYISSVAW-IKEGNY 77 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 ++ +WD + K ++ +H+A V LS+N +IL++GS + D Sbjct: 78 LAVGTSSAEVQLWDVQQQ---KRLRNMTSHSARVGSLSWN---SYILSSGSRSGHIHHHD 131 Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 +R + + + H E+ ++W+P LAS G D +NVW P +G Sbjct: 132 VRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVW----------PSAPGEG 180 Query: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQM 404 L H + +W P + V+ + D +++W + Sbjct: 181 GWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV 224 >6N9G-C nrPDB Length = 353 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 108/279 (38%), Gaps = 35/279 (12%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 V Y P + C IA + V+ T + + H S+ Sbjct: 107 WVMACAYAP-SGCAIACGGLDNKCSVYPLTFDKN----ENMAAKKKSVAMHTNYLSACSF 161 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE-SLFG 244 N +L+AS D T LWD+ + F GH A V + + F Sbjct: 162 T-NSDMQILTASGDGTCALWDVESG-------QLLQSFHGHGADVLCLDLAPSETGNTFV 213 Query: 245 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 S D+K M+WD RS + + H ++VN + + P + A+GS D T L+DLR Sbjct: 214 SGGCDKKAMVWDMRSGQC---VQAFETHESDVNSVRYYPSGD-AFASGSDDATCRLYDLR 269 Query: 305 -NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP 363 + ++ ++S ES V +S + A D +NVWD+ K Sbjct: 270 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGY-NDYTINVWDVLKGSRVS--------- 319 Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 I GH ++S +P+ CS S D+ ++VW Sbjct: 320 -----ILFGHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 77/212 (36%), Gaps = 28/212 (13%) Query: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 V+ + GH V + W + S + D K+++WD+ + N H+V Sbjct: 52 VMKTRRTLKGHGNKVLCMDWCKDKRRIV-SSSQDGKVIVWDSFTTN---KEHAVTMPCTW 107 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDL-----RNLKLKLHSFESHKDEIFQVQWSPHNE 330 V ++ P S +A G D +++ L N+ K S H + + ++ + Sbjct: 108 VMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP-WV 389 IL +SG D +WD+ +LL GH A + P+E Sbjct: 167 QILTASG-DGTCALWDVESG--------------QLLQSFHGHGADVLCLDLAPSETGNT 211 Query: 390 ICSVSEDNIMQVWQMAEN--IYNDEDPEGSVD 419 S D VW M + E E V+ Sbjct: 212 FVSGGCDKKAMVWDMRSGQCVQAFETHESDVN 243 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 47/133 (35%), Gaps = 18/133 (13%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 HE +VN RY P + A+ + + ++D D + Sbjct: 238 HESDVNSVRYYP-SGDAFASGSDDATCRLYDLR-----ADREVAIYSKESIIF---GASS 288 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + ++ L + +D+TI +WD+ + +I GH V + + Sbjct: 289 VDFS-LSGRLLFAGYNDYTINVWDVLKGSR-------VSILFGHENRVSTLRVSPDGTA- 339 Query: 243 FGSVADDQKLMIW 255 F S + D L +W Sbjct: 340 FCSGSWDHTLRVW 352 Score = 35.9 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 23/63 (36%), Gaps = 1/63 (1%) Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 R + D+ + E + GH K+ W ++ ++ S S+D + Sbjct: 30 RAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIV-SSSQDGKVI 88 Query: 401 VWQ 403 VW Sbjct: 89 VWD 91 >3JRP-A nrPDB Length = 379 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 108/299 (36%), Gaps = 47/299 (15%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW-NPNLSGHLLSASD 198 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 77 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH-ESLFGSVADDQKLMIWDT 257 D + +W +E + H+A V V W L + D K+ + + Sbjct: 78 DGKVLIWK-----EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 132 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 305 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 133 KENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 191 Query: 306 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + E H D + V WSP + LAS DR +W +D E Sbjct: 192 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 241 Query: 361 DGPPELLFIHGGHTAKISD-FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 GP + + + SW+ + V+ DN + +W+ EN+ +P G V Sbjct: 242 QGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTLWK--ENLEGKWEPAGEV 297 Score = 121 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 96/266 (36%), Gaps = 35/266 (13%) Query: 117 IEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 I+ HEG V R + P+ I+A+ + VL++ + +G + Sbjct: 48 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 99 Query: 176 HQKEGYGLSWNPN-LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 H + W P+ LL AS D + + + KE I H V S Sbjct: 100 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF----KENGTTSPI-IIDAHAIGVNSAS 154 Query: 235 WHLL------------HESLFGSVADDQKLMIWDTRS-NNTSKPSHSVDAHTAEVNCLSF 281 W F + D + IW S T +++ H+ V +++ Sbjct: 155 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 214 Query: 282 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHK--DEIFQVQWSPHNETILAS 335 +P LA+ S D+T +W D K + K D +++ WS +LA Sbjct: 215 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 273 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAED 361 SG D ++ +W + G+ + + Sbjct: 274 SGGDNKVTLWKENLEGKWEPAGEVHQ 299 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 84/231 (36%), Gaps = 33/231 (14%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVA 247 L + S D TI ++++ EG+ TGH V V W H ++ S + Sbjct: 22 YGKRLATCSSDKTIKIFEV-----EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 76 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLR-N 305 D K++IW N H+A VN + + P+ +L S+D V++ + + N Sbjct: 77 YDGKVLIW-KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 135 Query: 306 LKLKLHSFESHKDEIFQVQWSP------------HNETILASSGTDRRLNVWDLSKIGEE 353 ++H + W+P + G D + +W + + Sbjct: 136 GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 195 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVW 402 E GH+ + D +W+P + SVS+D +W Sbjct: 196 YVLES----------TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 >3JB9-L nrPDB Length = 340 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 69/324 (21%), Positives = 118/324 (36%), Gaps = 35/324 (10%) Query: 99 DSEKGEFGGFGSVSGKIEIE--IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 DS G + + + H EV AR+ P + A+ +L+++ Sbjct: 23 DSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDP-SGSYFASGGMDRQILLWNV-- 79 Query: 157 HPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 G+ L G + L W+ + S+SD H + WD + K Sbjct: 80 -------FGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTH-LMSWDAVSGQK---- 127 Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 GH VV + + L SV+DD + +WD+RS + K + Sbjct: 128 ---IRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKY----PL 180 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 ++ + G D + +WDLRN H + HKD I + S ++L S+ Sbjct: 181 TAVAIAQQGTQVFI-GGIDGAIKIWDLRNNHCS-HVLKGHKDIITSLAISKDGSSLL-SN 237 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + ++D+ Q +G G + +W+ N +V + S D Sbjct: 238 SMDNTVRIFDVKPFASAQRQLQIFEGAIH------GQEHNLLGVAWSRNSRFV-GAGSSD 290 Query: 397 NIMQVWQMAENI-YNDEDPEGSVD 419 + VW ++ Y EGSV+ Sbjct: 291 KNVYVWSATGDLRYVLPGHEGSVN 314 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 34/186 (18%), Positives = 75/186 (40%), Gaps = 19/186 (10%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 + I + + Q + + ++D + C+ L+G Sbjct: 169 DCIKTIEEKYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLR--------NNHCSHV--LKG 217 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD-AKTIFTGHTAVVEDVS 234 H+ L+ + + S LLS S D+T+ ++D+ + + + G + V+ Sbjct: 218 HKDIITSLAISKDGSS-LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVA 276 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 W + G+ + D+ + +W + T + + H VN + F+P+ + IL + S+ Sbjct: 277 WS-RNSRFVGAGSSDKNVYVW----SATGDLRYVLPGHEGSVNHVDFHPHQDIIL-SCSS 330 Query: 295 DKTVAL 300 D+T+ L Sbjct: 331 DRTIFL 336 Score = 44.8 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 32/87 (36%), Gaps = 13/87 (14%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 E + + +N + + +V V+ T P GH+ Sbjct: 267 GQEHNLLGVAW-SRNSRFVGAGSSDKNVYVWSATGDLRYVLP-----------GHEGSVN 314 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDIS 208 + ++P+ +LS S D TI L +++ Sbjct: 315 HVDFHPHQD-IILSCSSDRTIFLGELN 340 >5A9Q-0 nrPDB Length = 380 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 118/302 (39%), Gaps = 33/302 (10%) Query: 103 GEFGGF---GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 159 G+FG G G ++ I H G+V ++ Q + A+ T V + HP+ Sbjct: 50 GDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFL----HHPN 105 Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW-DISAVPKEGKVVD 218 S H G G +P+ S SA +C +I V ++G++ Sbjct: 106 NQTLSVN---QQWTTAHYHTGPG---SPSYS----SAPCTGVVCNNPEIVTVGEDGRINL 155 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLF------GSVADDQKLMIWDTR-SNNTSKPSHSVDA 271 + +++ LH F +V +L IWD R N S+ Sbjct: 156 FRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTG 215 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 331 ++C+ +P + ++ATG D +++WD+R + + ++H+ E+++V + P N Sbjct: 216 DRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPE 275 Query: 332 ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG------GHTAKISDFSWNPN 385 L + D L WD S E+S + G H H + IS SW Sbjct: 276 HLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVIS--SWLST 333 Query: 386 EP 387 +P Sbjct: 334 DP 335 >2PM9-A nrPDB Length = 416 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 111/293 (37%), Gaps = 30/293 (10%) Query: 134 PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHL 193 N IIA + + ++ S + + N R H + +N L Sbjct: 76 SHNNKIIAGALDNGSLELY------STNEANNAINSMARFSNHSSSVKTVKFNAKQDNVL 129 Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV--VEDVSWHLLHESLFGSVADDQK 251 S ++ I +WD++ + T ++V V ++W+ +F S Sbjct: 130 ASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNF 189 Query: 252 LMIWDTRSNN---TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA---DKTVALWDLRN 305 IWD ++ + +++ + ++P + +AT + D ++ +WDLRN Sbjct: 190 ASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRN 249 Query: 306 LKLKLHSF-ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPP 364 L + + H+ I + W +E +L SSG D + +W+ + Sbjct: 250 ANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQ--------- 300 Query: 365 ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 F G+ + F+ P P + S DN ++V Q +N+ N D + + Sbjct: 301 ---FPARGNWCFKTKFA--PEAPDLFACASFDNKIEV-QTLQNLTNTLDEQET 347 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 49/258 (18%), Positives = 102/258 (39%), Gaps = 7/258 (2%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 NH V ++ + ++A+ + ++ ++D K P P + E Sbjct: 111 NHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSS-VDEVI 169 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 L+WN +L+ SA + +WD+ KE + + +G + V WH + + Sbjct: 170 SLAWNQSLAHVFASAGSSNFASIWDL-KAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNST 228 Query: 242 LFGSVA---DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 + +D ++IWD R+ NT + + H + L + E +L + D TV Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLN-QGHQKGILSLDWCHQDEHLLLSSGRDNTV 287 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 LW+ +L F + + F+ +++P + A + D ++ V L + ++ Sbjct: 288 LLWN-PESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQE 346 Query: 359 AEDGPPELLFIHGGHTAK 376 E E + ++ Sbjct: 347 TETKQQESETDFWNNVSR 364 Score = 71.0 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 72/184 (39%), Gaps = 20/184 (10%) Query: 234 SWHLLHESLFGSV----------ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 +W L S + D L +W + ++ KP S+ + N L ++ Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSH 77 Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHS---FESHKDEIFQVQWSPHNETILASSGTDR 340 ++ I+A + ++ L+ ++S F +H + V+++ + +LAS G + Sbjct: 78 NNK-IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNG 136 Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 + +WD++K E S + P ++ +WN + V S N Sbjct: 137 EIFIWDMNKCTESPS-----NYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFAS 191 Query: 401 VWQM 404 +W + Sbjct: 192 IWDL 195 >3JAP-g nrPDB Length = 326 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 116/329 (35%), Gaps = 64/329 (19%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H G V P ++ + + ++ + T++ + P +GH Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQ-----FGVPVRSYKGHSHIVQ 70 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + + +SAS D T+ LW+++ E + F GHT V V+ + S Sbjct: 71 DVVVSAD-GNYAVSASWDKTLRLWNLATGNSEAR-------FVGHTGDVLSVAI-DANSS 121 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP---------YSEFILATG 292 S + D+ + +W+T ++ + HT V + P + Sbjct: 122 KIISASRDKTIRVWNT----VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSA 177 Query: 293 SADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS--- 348 DK V W L ++ F H + I VQ SP ++ AS+G D ++ VW+L Sbjct: 178 GMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDG-SLAASAGKDGQIYVWNLKHKS 236 Query: 349 -------------------------------KIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 KI + ++ ++ PE Sbjct: 237 AFMNFDAKDEVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHA 296 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 +W+ + + + DN+++VWQ+ Sbjct: 297 VSLAWSADGQTLFAGYT-DNVIRVWQVMT 324 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 94/244 (38%), Gaps = 31/244 (12%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 L GH LS + L+S S D T+ W ++ ++ V + GH+ +V+D Sbjct: 14 LEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGV--PVRSYKGHSHIVQD 71 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V + S + D+ L +W+ + N HT +V ++ + S I+ + Sbjct: 72 VVVSADG-NYAVSASWDKTLRLWNLATGN---SEARFVGHTGDVLSVAIDANSSKII-SA 126 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP---------HNETILASSGTDRRLN 343 S DKT+ +W+ + + H D + +V+ +P S+G D+ + Sbjct: 127 SRDKTIRVWN--TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVR 184 Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 W L++ + GH I+ +P+ + S +D + VW Sbjct: 185 SWSLNEDSYRIEADFI------------GHNNYINVVQPSPDGS-LAASAGKDGQIYVWN 231 Query: 404 MAEN 407 + Sbjct: 232 LKHK 235 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 77/224 (34%), Gaps = 36/224 (16%) Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDT--RSNNTSKPSHSVDAHTAEVN 277 + GH V +S +L S + D+ L+ W P S H+ V Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 + + + + + S DKT+ LW+L + F H ++ V ++ I+ S+ Sbjct: 71 DVVVSADGNYAV-SASWDKTLRLWNLATGNSEAR-FVGHTGDVLSVAIDANSSKII-SAS 127 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP---------NEPW 388 D+ + VW+ + ++ GHT ++ P + Sbjct: 128 RDKTIRVWN---------------TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRI 172 Query: 389 VICSVSEDNIMQVWQMAENIYNDEDP-------EGSVDPEGQGS 425 S D I++ W + E+ Y E V P GS Sbjct: 173 TFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGS 216 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 25/198 (12%), Positives = 56/198 (28%), Gaps = 34/198 (17%) Query: 118 EIKINHEGEVNRARYMPQN---------PCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 + + H V + R P+N + V + + + + Sbjct: 143 YVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIE------ 196 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 GH + +P+ S SA D I +W++ Sbjct: 197 --ADFIGHNNYINVVQPSPDGS-LAASAGKDGQIYVWNLKHKSAFMNFDAK--------D 245 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSH-SVDAHTAE----VNCLSFNP 283 V +++ + + A + I+D + +T L+++ Sbjct: 246 EVFALAFSP--SRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSA 303 Query: 284 YSEFILATGSADKTVALW 301 + + A G D + +W Sbjct: 304 DGQTLFA-GYTDNVIRVW 320 >5Y88-O nrPDB Length = 451 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 108/250 (43%), Gaps = 30/250 (12%) Query: 158 PSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVV 217 +P+ + GH ++ +P + ++ S+D T+ +WD++ Sbjct: 120 SQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG------- 172 Query: 218 DAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 277 KT GH V DV+ H LF SV++D+ + WD N + + H + V Sbjct: 173 KLKTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLEKNQIIRDYY---GHLSGVR 228 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 +S +P + I AT D + LWD+R ++ + + HK I QVQ +P + ++ SS Sbjct: 229 TVSIHPTLDLI-ATAGRDSVIKLWDMRT-RIPVITLVGHKGPINQVQCTPVDPQVV-SSS 285 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 TD + +WD+ + + + H + + +P E V + ++D Sbjct: 286 TDATVRLWDV--------------VAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD- 330 Query: 398 IMQVWQMAEN 407 ++ W +AE Sbjct: 331 -IRSWGLAEG 339 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 115/335 (34%), Gaps = 61/335 (18%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H G V P + T + + + V+D K L GH Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTT----------LAGHVMTVR 186 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 ++ + + +L S S+D T+ WD+ + GH + V VS H Sbjct: 187 DVAVS-DRHPYLFSVSEDKTVKCWDLEKN-------QIIRDYYGHLSGVRTVSIHPT-LD 237 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L + D + +WD R T P ++ H +N + P ++++ S D TV LW Sbjct: 238 LIATAGRDSVIKLWDMR---TRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLW 293 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 D+ K + HK + P ++ AS+ TD + W L++ + E + Sbjct: 294 DVVAGKT-MKVLTHHKRSVRATALHPKEFSV-ASACTDD-IRSWGLAEGSLLTNFESEKT 350 Query: 362 GPPELLFIHG--------------------GH--------------TAKISDFSWNPNEP 387 G L I+ GH + S ++ Sbjct: 351 GIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKT 410 Query: 388 WV-ICSVSEDNIMQVWQMAENIYNDEDPEGSVDPE 421 + + + D +++W+ E + +P + +P Sbjct: 411 GLRLITGEADKSIKIWKQDETATKESEPGLAWNPN 445 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 38/198 (19%), Positives = 78/198 (39%), Gaps = 21/198 (10%) Query: 207 ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 +S P+ + GH V V+ + F + ++D + +WD + Sbjct: 119 LSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT-- 176 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 ++ H V ++ + ++ + S DKTV WDL ++ + + H + V Sbjct: 177 -TLAGHVMTVRDVAVSDRHPYLFSV-SEDKTVKCWDLEKNQI-IRDYYGHLSGVRTVSIH 233 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 P + ++A++G D + +WD+ + GH I+ P + Sbjct: 234 PTLD-LIATAGRDSVIKLWDMRTRIPVITLV--------------GHKGPINQVQCTPVD 278 Query: 387 PWVICSVSEDNIMQVWQM 404 P V+ S S D +++W + Sbjct: 279 PQVV-SSSTDATVRLWDV 295 >2AQ5-A nrPDB Length = 402 Score = 148 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 47/227 (20%), Positives = 98/227 (43%), Gaps = 11/227 (4%) Query: 153 DYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 212 + +P + +C D+R+ + + NP + AS + + K Sbjct: 10 KFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPL---GK 66 Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS----KPSHS 268 G+V + GHTA V D++W ++++ S ++D +M+W+ +P + Sbjct: 67 TGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVIT 126 Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS-FESHKDEIFQVQWSP 327 ++ HT V ++++P ++ +L + D + +WD+ L + H D I+ V WS Sbjct: 127 LEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSR 186 Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGG 372 ++ +S D+R+ V + K + +G P +F+ G Sbjct: 187 DGA-LICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEG 232 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 98/279 (35%), Gaps = 18/279 (6%) Query: 108 FGSVSGKIEIEIKINHEGEVNRARYM---PQNPCIIATKTPSSDVLVFDYTKHPSKPDPS 164 FG + + + + + P+ +I + LV K Sbjct: 15 FGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGR----V 70 Query: 165 GECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 224 + P + GH ++W P+ + S S+D T+ +W+I + + Sbjct: 71 DKNVPLVC--GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLE 128 Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284 GHT V V+WH +++ S D +++WD + D H + + ++ Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL-GPDVHPDTIYSVDWSRD 187 Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKD--EIFQVQWSPHNETILASS---GTD 339 I T DK V + + R + H+ + V S IL + ++ Sbjct: 188 GALI-CTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSE--GKILTTGFSRMSE 244 Query: 340 RRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 378 R++ +WD + E S ++ + LL T + Sbjct: 245 RQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVY 283 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 7/93 (7%) Query: 315 SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374 H + + W PHN+ ++AS D + VW++ G E + GHT Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLR-------EPVITLEGHT 131 Query: 375 AKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 ++ +W+P V+ S DN++ VW + Sbjct: 132 KRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTG 164 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 26/52 (50%) Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQ 423 GHTA + D +W P+ VI S SED + VW++ + E + EG Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGH 130 >5XYI-g nrPDB Length = 335 Score = 148 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 116/304 (38%), Gaps = 37/304 (12%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 + H + + + + + LV+ + + P RL GH Sbjct: 30 VGHNAAIESIE-IDNEHNYLVSASRDKSALVWKLNRTQEQWA-----TPFTRLIGHNHFV 83 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 +S + + S HLL++S D T+ LWD+S K +F GH V V++ + Sbjct: 84 SDVSLSRDAS-HLLTSSWDSTLRLWDLS-------TRTTKKLFLGHKKDVLGVTFSPCNR 135 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF-NPYSEFILATGSADKTVA 299 + SV D ++ IW+ N K + V C + S ++A G D V Sbjct: 136 RII-SVGRDNQVKIWNILGEN--KAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVY 192 Query: 300 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 +W + + F++H V ++P + ++ + G+DR++ +W Sbjct: 193 IWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVI-TGGSDRKVVMW------------LT 239 Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 E+G + F + + + P + W+ + E + VW + D + + Sbjct: 240 ENGAKTISFTAP---SPVHAVAACPTQAWICAATYEG--IAVWDIGAKQQIDL-VQPNFK 293 Query: 420 PEGQ 423 EG+ Sbjct: 294 HEGK 297 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 31/89 (34%), Gaps = 8/89 (8%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN---PDLRLRGHQKEGY 181 V+ P I A T + V+D + + N R G + Sbjct: 252 SPVHAVAACPTQAWICA-ATYEG-IAVWDI--GAKQQIDLVQPNFKHEGKRNAGRTPDCT 307 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAV 210 L+W + S L S +D +I W++ + Sbjct: 308 CLAWAADGS-VLYSGYNDGSIRAWEVKSA 335 >5NZU-C nrPDB Length = 905 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 92/247 (37%), Gaps = 23/247 (9%) Query: 129 RARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN 188 RA + T + VF+Y H ++ +P Sbjct: 61 RAAKFVARKNWVVTGADDMQIRVFNYNTLER----------VHMFEAHSDYIRCIAVHPT 110 Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 248 +L++SDD I LWD K +F GHT V + + + F S + Sbjct: 111 QP-FILTSSDDMLIKLWDWD------KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASL 163 Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE-FILATGSADKTVALWDLRNLK 307 D+ + +W +S P+ +++ H VNC+ + + L +G+ D+ V +WD +N K Sbjct: 164 DRTIKVWQL---GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN-K 219 Query: 308 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELL 367 + + E H + + P I+ + D + +W S E + + + Sbjct: 220 TCVQTLEGHAQNVSCASFHPELP-IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Query: 368 FIHGGHT 374 + G + Sbjct: 279 SLRGSNN 285 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 97/263 (36%), Gaps = 44/263 (16%) Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 229 +L + +P L S + ++C+W+ F Sbjct: 8 KRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQ-------TLVKTFEVCDLP 59 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 V + + ++ + ADD ++ +++ NT + H +AH+ + C++ +P FIL Sbjct: 60 VRAAKF-VARKNWVVTGADDMQIRVFNY---NTLERVHMFEAHSDYIRCIAVHPTQPFIL 115 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 T S D + LWD FE H + Q+ +P + AS+ DR + VW L Sbjct: 116 -TSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS 174 Query: 350 IGEEQSPEDAEDGPPELLFIHG------------------------------GHTAKISD 379 + E E G + + G GH +S Sbjct: 175 SSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSC 234 Query: 380 FSWNPNEPWVICSVSEDNIMQVW 402 S++P P +I + SED +++W Sbjct: 235 ASFHPELP-IIITGSEDGTVRIW 256 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 46/230 (20%), Positives = 86/230 (37%), Gaps = 24/230 (10%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 + + H + P P I+ + + + ++D+ K + + G Sbjct: 91 RVHMFEAHSDYIRCIAVHPTQPFILTS-SDDMLIKLWDWDK---------KWSCSQVFEG 140 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H + NP + SAS D TI +W + + GH V + + Sbjct: 141 HTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS-------PNFTLEGHEKGVNCIDY 193 Query: 236 HLLHES-LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + S ADD+ + IWD ++ +++ H V+C SF+P I+ TGS Sbjct: 194 YSGGDKPYLISGADDRLVKIWDYQNKTC---VQTLEGHAQNVSCASFHPELP-IIITGSE 249 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 D TV +W +L+ + ++ V S +A + + V Sbjct: 250 DGTVRIWHSSTYRLESTLNYG-MERVWCVA-SLRGSNNVALGYDEGSIIV 297 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 46/205 (22%), Positives = 79/205 (38%), Gaps = 22/205 (10%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 +D K T + V+ V H + S+ + + +W+ + K D V Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTFEVCD---LPV 60 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 F +++ TG+ D + +++ L+ ++H FE+H D I + P IL SS Sbjct: 61 RAAKFVARKNWVV-TGADDMQIRVFNYNTLE-RVHMFEAHSDYIRCIAVHPTQPFILTSS 118 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + +WD K + GHT + NP + S S D Sbjct: 119 D-DMLIKLWDWDK-------------KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLD 164 Query: 397 NIMQVWQMAENIYND--EDPEGSVD 419 ++VWQ+ + N E E V+ Sbjct: 165 RTIKVWQLGSSSPNFTLEGHEKGVN 189 >4BZK-B nrPDB Length = 297 Score = 147 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 108/299 (36%), Gaps = 47/299 (15%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW-NPNLSGHLLSASD 198 +AT + + +F+ K + L GH+ + + W +P L S S Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDT--------LTGHEGPVWRVDWAHPKFGTILASCSY 75 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH-ESLFGSVADDQKLMIWDT 257 D + +W +E + H+A V V W L + D K+ + + Sbjct: 76 DGKVLIWK-----EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNP------------YSEFILATGSADKTVALWDLRN 305 + N T+ P +DAH VN S+ P TG AD V +W + Sbjct: 131 KENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 306 LKLKL---HSFESHKDEIFQVQWSPHN--ETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + E H D + V WSP + LAS DR +W +D E Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNE 239 Query: 361 DGPPELLFIHGGHTAKISD-FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 GP + + + SW+ + V+ DN + +W+ EN+ +P G V Sbjct: 240 QGPWKKTLLKEEKFPDVLWRASWSLSG-NVLALSGGDNKVTLWK--ENLEGKWEPAGEV 295 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 96/266 (36%), Gaps = 35/266 (13%) Query: 117 IEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 I+ HEG V R + P+ I+A+ + VL++ + +G + Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK--------EENGRWSQIAVHAV 97 Query: 176 HQKEGYGLSWNPN-LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 H + W P+ LL AS D + + + KE I H V S Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF----KENGTTSPI-IIDAHAIGVNSAS 152 Query: 235 WHLL------------HESLFGSVADDQKLMIWDTRS-NNTSKPSHSVDAHTAEVNCLSF 281 W F + D + IW S T +++ H+ V +++ Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAW 212 Query: 282 NPY--SEFILATGSADKTVALW--DLRNLKLKLHSFESHK--DEIFQVQWSPHNETILAS 335 +P LA+ S D+T +W D K + K D +++ WS +LA Sbjct: 213 SPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSG-NVLAL 271 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAED 361 SG D ++ +W + G+ + + Sbjct: 272 SGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 84/231 (36%), Gaps = 33/231 (14%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVA 247 L + S D TI ++++ EG+ TGH V V W H ++ S + Sbjct: 20 YGKRLATCSSDKTIKIFEV-----EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLR-N 305 D K++IW N H+A VN + + P+ +L S+D V++ + + N Sbjct: 75 YDGKVLIW-KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN 133 Query: 306 LKLKLHSFESHKDEIFQVQWSP------------HNETILASSGTDRRLNVWDLSKIGEE 353 ++H + W+P + G D + +W + + Sbjct: 134 GTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVW 402 E GH+ + D +W+P + SVS+D +W Sbjct: 194 YVLES----------TLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 >4YCZ-A nrPDB Length = 876 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 119/337 (35%), Gaps = 54/337 (16%) Query: 107 GFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGE 166 G GS++ ++ H+ ++ A + +AT + + +F+ + + Sbjct: 1 GPGSMAAGTQVIANSGHDDMIHDAV-LDYYGRRLATCSSDRTIKIFEIEGETQRLTET-- 57 Query: 167 CNPDLRLRGHQKEGYGLSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 225 L+GH + +SW +P L SA D + +W + F Sbjct: 58 ------LKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIW-----RELNGAWQRIFDFAL 106 Query: 226 HTAVVEDVSWHLLHES-LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP- 283 H A V VSW L + D + + + R N+ AH VN +S+ P Sbjct: 107 HKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSI--FHAHGLGVNSVSWAPA 164 Query: 284 ---------------YSEFILATGSADKTVALWDLR----NLKLKLHSFESHKDEIFQVQ 324 TG +D + +W KL+ H D + V Sbjct: 165 TSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVA 224 Query: 325 WSPHN--ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 WSP ++ +AS+ DR + +W + L F A + SW Sbjct: 225 WSPTVLQKSYIASASEDRTVRIW------TSDPANPLQWNCKVLNF-----DAAVWRVSW 273 Query: 383 NPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 + + V+ + DN + +W+ EN+ + + +++ Sbjct: 274 SLSG-NVLAASGGDNKVTLWK--ENLKGEWECVKTIE 307 >6F1U-h nrPDB Length = 612 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 76/368 (20%), Positives = 141/368 (38%), Gaps = 40/368 (10%) Query: 58 GKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEI 117 + +S HR+V S + L++AS N+DA + G + K Sbjct: 247 DERWSKHRVVSCLDWSSQYPELLVASYN-NNEDAPHEP------DGVALVWNMKYKKTTP 299 Query: 118 EIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQ 177 E + + V A + +P ++ T S ++++D + P + P L H Sbjct: 300 EYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTP---VQRTP-LSAAAHT 355 Query: 178 KEGYGLSWNPNLSGH-LLSASDDHTICLWDISAVPKEGKVVD------AKTIFTGHTAVV 230 Y ++ + H L+S S D IC W + + ++ T + V Sbjct: 356 HPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPV 415 Query: 231 EDVSWHLLHE---SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 DV+ ++ S++ + K I + + P + H A V + F+ Sbjct: 416 GDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQG-PITGIHCHAA-VGAVDFS----H 469 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + T S D TV LW +N K L+SFE + ++ V WSP + + A RL++W+L Sbjct: 470 LFVTSSFDWTVKLWSTKNNK-PLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNL 528 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + E + + +G P L + H+ + I + + ++ + E Sbjct: 529 NNDTEVPTASISVEGNPALNRVRWTHSGR------------EIAVGDSEGQIVIYDVGEQ 576 Query: 408 IYNDEDPE 415 I + E Sbjct: 577 IAVPRNDE 584 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 52/306 (16%), Positives = 90/306 (29%), Gaps = 49/306 (16%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 N A P LV++ + P+ C Q ++ Sbjct: 271 ASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHC---------QSAVMSATFAKFHPNL 321 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVADDQK 251 ++ + I LWD + + + HT V V+ + S++ D K Sbjct: 322 VVGGTYSGQIVLWDNRSNKRTPVQRTPLSA-AAHTHPVYCVNVVGTQNAHNLISISTDGK 380 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAE----VNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 + W + + S + H V +SF GS + +V R+ Sbjct: 381 ICSWSLDMLSHPQDSMEL-VHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-ACRHGS 438 Query: 308 LK--LHSFESHKDEIF---------QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 FE H+ I V +S + +S D + +W S Sbjct: 439 KAGISEMFEGHQGPITGIHCHAAVGAVDFS----HLFVTSSFDWTVKLWSTKNNKPLYSF 494 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 ED + D W+P P + V + +W + + E P Sbjct: 495 EDNA--------------GYVYDVMWSPTHPALFACVDGMGRLDLWNLNN---DTEVPTA 537 Query: 417 SVDPEG 422 S+ EG Sbjct: 538 SISVEG 543 >4L9O-A nrPDB Length = 349 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 110/293 (37%), Gaps = 41/293 (13%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW-NPNLSGHLLSASD 198 +AT + + +F+ L GH+ + ++W +P L S S Sbjct: 84 LATCSSDKTIKIFEI--------DGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSY 135 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH-ESLFGSVADDQKLMIWDT 257 D + +W ++ V + + H A V VSW + + D K+ I + Sbjct: 136 DGKVLIWK-----EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEF 190 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFN----PYSEFILATGSADKTVALW---DLRNLKLKL 310 + +P + H VN S+ P + +G D V +W D ++ Sbjct: 191 KDGGALEPI-VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEE 249 Query: 311 HSFESHKDEIFQVQWSPH--NETILASSGTDRRLNVW--DLSKIGEEQSPEDAEDGPPEL 366 +F+ H D + V WSP +++ +A++ DR + +W D E+ P E P Sbjct: 250 EAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVC 309 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 SW+ + V+ DN + +W+ ENI + G VD Sbjct: 310 -----------WRASWSLSG-NVLAISGGDNKVTLWK--ENIQGKWESAGEVD 348 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 89/237 (37%), Gaps = 26/237 (10%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVA 247 L + S D TI +++I + GH V V+W H + S + Sbjct: 80 YGRRLATCSSDKTIKIFEIDGENQ-----RLVETLIGHEGPVWQVAWAHPKFGVILASCS 134 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS-EFILATGSADKTVALWDLRN- 305 D K++IW N H A VN +S+ P+ +L S+D +++ + ++ Sbjct: 135 YDGKVLIW-KEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDG 193 Query: 306 LKLKLHSFESHKDEIFQVQWS----PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 L+ + H + W+ P N S G D + +W + E+A Sbjct: 194 GALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEA-- 251 Query: 362 GPPELLFIHGGHTAKISDFSWNPNE--PWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 GH+ + D +W+P+ I + S+D + +W + N + + Sbjct: 252 --------FQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW-TKDGKSNKWEKQP 299 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 16/108 (14%), Positives = 36/108 (33%), Gaps = 14/108 (12%) Query: 315 SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374 +H D I + LA+ +D+ + + + + L+ GH Sbjct: 67 AHDDLIHDAVLDYYGRR-LATCSSDKTIKI------------FEIDGENQRLVETLIGHE 113 Query: 375 AKISDFSW-NPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPE 421 + +W +P ++ S S D + +W+ ++N Sbjct: 114 GPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQAS 161 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 29/135 (21%), Positives = 52/135 (38%), Gaps = 14/135 (10%) Query: 77 NHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQ- 135 N A + LP++ +F + D+ + + IE E H V + P Sbjct: 209 NAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSR 268 Query: 136 -NPCIIATKTPSSDVLVF--DYTKHPSKPDP-SGECNPDLRLRGHQKEGYGLSWNPNLSG 191 + IAT + VL++ D + + P + E PD+ R SW+ + + Sbjct: 269 LSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRA--------SWSLSGNV 320 Query: 192 HLLSASDDHTICLWD 206 +S D+ + LW Sbjct: 321 LAISGG-DNKVTLWK 334 >5WYJ-BC nrPDB Length = 817 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 70/346 (20%), Positives = 134/346 (38%), Gaps = 47/346 (13%) Query: 73 SDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARY 132 S+ Q LV++ L + + D + D + + S++G I + + G Sbjct: 298 SNSQMFLVLSDQTLQLINVEEDLKN-DEDTIQVTS--SIAGNHGIIADMRYVGPEL---- 350 Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 N +AT +PS ++ P P GH+ L + Sbjct: 351 ---NKLALATNSPSLRIIPVPDLSGPEASLPLD----VEIYEGHEDLLNSLDATED-GLW 402 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW----HLLHESLFGSVAD 248 + +AS D+T +W + D + GH+A V V + + ++ Sbjct: 403 IATASKDNTAIVW---RYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASN 459 Query: 249 DQKLMIWDTRSNNTSKPSHSV-------DAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 D + W S + AH ++N LS +P ++ I AT S DKT +W Sbjct: 460 DLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP-NDSIFATASYDKTCKIW 518 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 +L N +L+ + +HK ++ V + +++ +LA+S D+ + +W L ++ E Sbjct: 519 NLENGELE-ATLANHKRGLWDVSFCQYDK-LLATSSGDKTVKIWSLDTFSVMKTLE---- 572 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 GHT + S+ + +I S D ++++W + Sbjct: 573 ----------GHTNAVQRCSFINKQKQLI-SCGADGLIKIWDCSSG 607 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 129/325 (39%), Gaps = 37/325 (11%) Query: 109 GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168 S +++EI HE +N ++ IAT + + +V+ Y ++ K D Sbjct: 373 PEASLPLDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVWRYNENSCKFDIY---- 427 Query: 169 PDLRLRGHQKEGYGL----SWNPNLSGHLLSASDDHTICLWDI---SAVPKEGKVVDAKT 221 + GH + + LL+AS+D TI W I +A + ++ Sbjct: 428 --AKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEY 485 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 H + +S ++S+F + + D+ IW+ + + ++ H + +SF Sbjct: 486 TRHAHEKDINALSVSP-NDSIFATASYDKTCKIWNLENG---ELEATLANHKRGLWDVSF 541 Query: 282 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 341 Y + +LAT S DKTV +W L + + + E H + + + + + + L S G D Sbjct: 542 CQY-DKLLATSSGDKTVKIWSLDTFSV-MKTLEGHTNAVQRCSFI-NKQKQLISCGADGL 598 Query: 342 LNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 + +WD S E L GH ++ S N+ +I S D + Q Sbjct: 599 IKIWDCSSG--------------ECLKTLDGHNNRLWALS-TMNDGDMIVSADADGVFQF 643 Query: 402 W-QMAENIYNDEDPEGSVDPEGQGS 425 W E +E + + E + S Sbjct: 644 WKDCTEQEIEEEQEKAKLQVEQEQS 668 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 101/303 (33%), Gaps = 41/303 (13%) Query: 122 NHEGEVNRARYMPQNPC---IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 H G ++ ++ Q ++A+ + V V+D K L+ H Sbjct: 142 GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHT----------LQEHTS 191 Query: 179 EGYGLSW-----NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 GL N S +LLS D I LWD + K + VE Sbjct: 192 AVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPV-----NQQVESC 246 Query: 234 SWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 + + + + D + D+ S + K ++ + L S+ L Sbjct: 247 GFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVL 306 Query: 292 GSADKTVALW----DLRNLKLKLH---SFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 +D+T+ L DL+N + + S + I +++ LA + L + Sbjct: 307 --SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRI 364 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 E P + I+ GH ++ + W I + S+DN VW+ Sbjct: 365 ------IPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLW-IATASKDNTAIVWRY 417 Query: 405 AEN 407 EN Sbjct: 418 NEN 420 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 36/182 (19%), Positives = 73/182 (40%), Gaps = 29/182 (15%) Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 + + + L V+ Q L I+ ++ + ++ L + S +L Sbjct: 64 ITALKLTPDGQYL-TYVSQAQLLKIFHLKTGKVVRSMKI----SSPSYILDADSTS-TLL 117 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW--SPHNE-TILASSGTDRRLNVWD 346 A G D ++ + D+ N + HSF+ H I +++ +++ +LAS T+ + VWD Sbjct: 118 AVGGTDGSIIVVDIENGYI-THSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWD 176 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW----NPNEPWV-ICSVSEDNIMQV 401 L K + L HT+ + + +EP + + S D+I+ + Sbjct: 177 LVKR--------------KCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINL 222 Query: 402 WQ 403 W Sbjct: 223 WD 224 >5UZ7-B nrPDB Length = 351 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 99/282 (35%), Gaps = 38/282 (13%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 V Y P + +A + +++ G L GH Sbjct: 107 RSSWVMTCAYAP-SGNYVACGGLDNICSIYNLK------TREGNVRVSRELAGHTGYLSC 159 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + ++++S D T LWDI + HT V +S L Sbjct: 160 CRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTG-------HTGDVMSLSLAP-DTRL 209 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 F S A D +WD R + + H +++N + F P ATGS D T L+D Sbjct: 210 FVSGACDASAKLWDVREGMCRQ---TFTGHESDINAICFFPNG-NAFATGSDDATCRLFD 265 Query: 303 LR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 LR + +L +S ++ I V +S +LA D NVWD K Sbjct: 266 LRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD-DFNCNVWDALKADRA-------- 316 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + GH ++S ++ + + S D+ +++W Sbjct: 317 ------GVLAGHDNRVSCLGVT-DDGMAVATGSWDSFLKIWN 351 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 94/257 (36%), Gaps = 31/257 (12%) Query: 154 YTKHPSKPDPSG--ECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVP 211 ++ + DP G + LRGH + Y + W S L+SAS D + +WD Sbjct: 41 LSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHW-GTDSRLLVSASQDGKLIIWDSYTTN 99 Query: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS-NNTSKPSHSVD 270 K ++ V ++ + D I++ ++ + S + Sbjct: 100 K-------VHAIPLRSSWVMTCAYAPSG-NYVACGGLDNICSIYNLKTREGNVRVSRELA 151 Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 330 HT ++C F ++ + T S D T ALWD+ + H ++ + +P Sbjct: 152 GHTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETGQQTTTFTG-HTGDVMSLSLAPDTR 208 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 390 + S D +WD+ + Q+ GH + I+ + PN Sbjct: 209 -LFVSGACDASAKLWDVREGMCRQT--------------FTGHESDINAICFFPNG-NAF 252 Query: 391 CSVSEDNIMQVWQMAEN 407 + S+D +++ + + Sbjct: 253 ATGSDDATCRLFDLRAD 269 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 75/195 (38%), Gaps = 25/195 (12%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 + + GH A + + W L S + D KL+IWD + T+ H++ ++ V Sbjct: 56 MRTRRTLRGHLAKIYAMHWG-TDSRLLVSASQDGKLIIWD---SYTTNKVHAIPLRSSWV 111 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH---SFESHKDEIFQVQWSPHNETIL 333 ++ P + +A G D ++++L+ + + H + ++ ++ + Sbjct: 112 MTCAYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF--LDDNQI 168 Query: 334 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV 393 +S D +WD+ + + HT + S P+ + S Sbjct: 169 VTSSGDTTCALWDIETGQQTTTFTG--------------HTGDVMSLSLAPD-TRLFVSG 213 Query: 394 SEDNIMQVWQMAENI 408 + D ++W + E + Sbjct: 214 ACDASAKLWDVREGM 228 >5A31-R nrPDB Length = 386 Score = 141 bits (355), Expect = 6e-34, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 98/257 (38%), Gaps = 30/257 (11%) Query: 103 GEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 G G +G +EI + + G ++R + N ++ + + +L D Sbjct: 143 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDV-- 200 Query: 157 HPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 PDP E + H +E GL WN L S +D+ + ++ EG Sbjct: 201 --RMPDPFFET-----IESHTQEVCGLKWN-VADNKLASGGNDNVVHVY-------EGTS 245 Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD--DQKLMIWDTRSNNTSKPSHSVDAHTA 274 F H A V+ ++W + + D++L IW+ NTS +D+ + Sbjct: 246 KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNV---NTSIKMSDIDSGSQ 302 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334 N + +E + + G + + LWD ++ + + H + + S ++ T + Sbjct: 303 ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMD-PIAILKGHSFRVLHLTLS-NDGTTVV 360 Query: 335 SSGTDRRLNVWDLSKIG 351 S D L W L + Sbjct: 361 SGAGDETLRYWKLFDVS 377 Score = 111 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 57/292 (19%), Positives = 114/292 (39%), Gaps = 44/292 (15%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 ++ + E E ++ +A + V ++D K L G Sbjct: 123 DVVHLCDTENEYTSLSWIGAGSH-LAVGQANGLVEIYDVMKRKC----------IRTLSG 171 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H LSWN + L S S DH I D+ HT V + W Sbjct: 172 HIDRVACLSWN---NHVLTSGSRDHRILHRDVRMPD------PFFETIESHTQEVCGLKW 222 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS-- 293 + + ++ S +D + +++ + P + D H A V ++++P+ +LATG Sbjct: 223 N-VADNKLASGGNDNVVHVYE---GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGT 278 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR-RLNVWDLSKIGE 352 AD+ + +W++ N +K+ +S V WS + ++ S G + L +WD + + Sbjct: 279 ADRRLKIWNV-NTSIKMSDIDSGSQICNMV-WSKNTNELVTSHGYSKYNLTLWDCNSMDP 336 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 + I GH+ ++ + + + V+ S + D ++ W++ Sbjct: 337 --------------IAILKGHSFRVLHLTLSNDGTTVV-SGAGDETLRYWKL 373 >6EOJ-D nrPDB Length = 470 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 81/378 (21%), Positives = 146/378 (38%), Gaps = 45/378 (11%) Query: 44 SLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKG 103 S T +P G+D I+ TH S + VI ++Q + + + Y G Sbjct: 60 SYTIDIMP-PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY---SG 115 Query: 104 EFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDP 163 EF + + S E ++ H+ V +Y + + + + ++ P Sbjct: 116 EFSLWNASSFTFETLMQ-AHDSAVTTMKY-SHDSDWMISGDADGMIKIW---------QP 164 Query: 164 SGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIF 223 + ++ H + ++++ N S ++ SDD+ + +W+ S +E + Sbjct: 165 NFSMVKEID-AAHTESIRDMAFSSNDS-KFVTCSDDNILKIWNFSNGKQE-------RVL 215 Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 +GH V+ WH L S + D + +WD RS N HT V F P Sbjct: 216 SGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFK-HT--VLKTRFQP 271 Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 +L S DK+ ++D+R +L D + ++W P NE++ + D L Sbjct: 272 TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINESMFTLACYDGSLK 330 Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 +DL + E +L I H I+ S+NP + + ++D ++ W Sbjct: 331 HFDLLQNLNEP-----------ILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWT 378 Query: 404 MAENIYNDEDPEGSVDPE 421 A I DP DP Sbjct: 379 RARPI----DPNAYDDPT 392 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 59/357 (16%), Positives = 130/357 (36%), Gaps = 26/357 (7%) Query: 27 NTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQL 86 N P + + ++ ++ QW P+ R +S + + + + + Sbjct: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV 138 Query: 87 PNDDAQFDASHYDSEKGE-FGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTP 145 D+ S + + + EI H + + N T + Sbjct: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSD 197 Query: 146 SSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW 205 + + +++++ + L GH + W+P G + SAS D+ + LW Sbjct: 198 DNILKIWNFSNGKQ----------ERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLW 246 Query: 206 DISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKP 265 D P+ G + + F HT V + +L +++ D+ ++D R + K Sbjct: 247 D----PRSGNCISSILKFK-HT--VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSM--KE 297 Query: 266 SHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL-RNLKLKLHSF-ESHKDEIFQV 323 V T + L ++P +E + D ++ +DL +NL + + +H I + Sbjct: 298 LMCVRDETDYMT-LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 380 ++P I A++ DR + W ++ + + +D ++ G I+ Sbjct: 357 SYNPVGH-IFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAV 412 >3MKQ-A nrPDB Length = 814 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 96/275 (34%), Gaps = 45/275 (16%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 G+ ++P L + + +W+ + + +T V Sbjct: 9 FSNRSDRVKGIDFHPTEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTET-------PVRA 60 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + +DD ++ +++ NT + +AH + ++ +P ++L +G Sbjct: 61 GKFIARKNWIIV-GSDDFRIRVFNY---NTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D TV LW+ N +FE H+ + V ++P + + AS DR + VW L + Sbjct: 116 SDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 353 EQSPEDAEDG-------------------------------PPELLFIHGGHTAKISDFS 381 + ++ + GH + +S Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 382 WNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 ++P P +I S SED +++W + G Sbjct: 236 FHPTLP-IIISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 109/306 (35%), Gaps = 36/306 (11%) Query: 112 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 ++E+ E V +++ + II + + VF+Y D Sbjct: 43 ETQVEVRSIQVTETPVRAGKFIARKNWIIV-GSDDFRIRVFNYNTGEKVVD--------- 92 Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 H ++ +P ++LS SDD T+ LW+ + F GH V Sbjct: 93 -FEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENN------WALEQTFEGHEHFVM 144 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE-FILA 290 V+++ S F S D+ + +W ++ VN + + P + + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 T S D T+ +WD + K + + E H + + P I+ S D L +W+ S Sbjct: 203 TASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTY 260 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISD--------FSWNPNEPWVICSVSEDNIMQ-V 401 E++ + + G I+ S +EP + S D + + V Sbjct: 261 KVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTL----SLDPVGKLV 316 Query: 402 WQMAEN 407 W +N Sbjct: 317 WSGGKN 322 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 37/200 (18%), Positives = 75/200 (37%), Gaps = 20/200 (10%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 +D K F+ + V+ + +H + ++ ++ IW+ + + + V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTE---TPV 58 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 F +I+ GS D + +++ N K+ FE+H D I + P +L S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + +W+ + L GH + ++NP +P S D Sbjct: 116 SDDLTVKLWN-------------WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLD 162 Query: 397 NIMQVWQMAENIYNDEDPEG 416 ++VW + ++ N G Sbjct: 163 RTVKVWSLGQSTPNFTLTTG 182 >5OQL-d nrPDB Length = 446 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 113/306 (36%), Gaps = 45/306 (14%) Query: 107 GFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSD----------VLVFDYTK 156 GS G +++ + E R + I+ T ++D + ++D Sbjct: 83 ASGSGDGVVKVWDLTTRDEETWRVAA---HNNIVKGLTFTNDKKLLSCATDGIKLWDPYA 139 Query: 157 HPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 PS P LS++ + + S+ I +WD+ + Sbjct: 140 SPSNTTPIATWQEG-------GPYTSLSFHRSANTFAASSGQ-GCIRIWDLEHSTAGQAI 191 Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 + + DV ++ + S+ GSVA D+ ++++D R+N P H A Sbjct: 192 QWPSFV-----DTITDVCFNQVETSVIGSVATDRSIILFDLRTN---MPVIKTVLHFA-C 242 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 N + FNP LA S D + ++D RN L+ + H + V++SP E L S Sbjct: 243 NRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSG 301 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 DR + +W D H ++ W + +++ + S+D Sbjct: 302 SYDRTIRLWR-------------RDAGHSRDVYHTKRMQRVFRTMWTMDSKYIL-TGSDD 347 Query: 397 NIMQVW 402 +++W Sbjct: 348 GNVRLW 353 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 94/258 (36%), Gaps = 41/258 (15%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + Y + + N + S S D + +WD++ +E V H +V+ ++ Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRV------AAHNNIVKGLT 117 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + ++ S A D + +WD ++ ++ + LSF+ S A S Sbjct: 118 F--TNDKKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHR-SANTFAASSG 173 Query: 295 DKTVALWDLR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 + +WDL + + + S D I V ++ +++ S TDR + ++DL Sbjct: 174 QGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPV 233 Query: 354 QSPEDA-----------------------------EDGPPELLFIHGGHTAKISDFSWNP 384 + L I GH A + D ++P Sbjct: 234 IKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSP 293 Query: 385 NEPWVICSVSEDNIMQVW 402 ++ S S D +++W Sbjct: 294 TGEELV-SGSYDRTIRLW 310 Score = 68.3 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 15/149 (10%) Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 329 + H V + + S +A+GS D V +WDL + +H + + + + N Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TN 120 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 + L S TD + +WD P + + G + S++ + Sbjct: 121 DKKLLSCATDG-IKLWD---------PYASPSNTTPIATWQEG--GPYTSLSFHRSA-NT 167 Query: 390 ICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 + S +++W + + S Sbjct: 168 FAASSGQGCIRIWDLEHSTAGQAIQWPSF 196 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 62/185 (33%), Gaps = 19/185 (10%) Query: 38 HALEWPSLT--------AQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPND 89 A++WPS Q V D SI L T+ + L A ++ + Sbjct: 189 QAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFN 248 Query: 90 DAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDV 149 + SE F + + + I+ H V + P + + + + Sbjct: 249 PMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSP-TGEELVSGSYDRTI 307 Query: 150 LVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA 209 ++ S+ R+ + + W + S ++L+ SDD + LW +A Sbjct: 308 RLWRRDAGHSRD-----VYHTKRM----QRVFRTMWTMD-SKYILTGSDDGNVRLWRANA 357 Query: 210 VPKEG 214 + G Sbjct: 358 SERSG 362 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 16/48 (33%) Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 GH + + N I S S D +++VW + + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNN 111 >5Z56-q nrPDB Length = 504 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 111/299 (37%), Gaps = 51/299 (17%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 P + I T +V+VFD + L+GH K+ + ++P+ Sbjct: 230 CPSDTNKILTGGADKNVVVFDKSSE----------QILATLKGHTKKVTSVVFHPSQD-L 278 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 + SAS D TI +W + + H + V +S H + L S +DDQ Sbjct: 279 VFSASPDATIRIWSVPNAS-------CVQVVRAHESAVTGLSLHATGDYLL-SSSDDQYW 330 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 D ++ + + + C F+P I TG+ D + +WDL+ + + + Sbjct: 331 AFSDIQTGRVLTKV-TDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLK-ERTNVAN 387 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE-DAEDGPPELLFIHG 371 F H I + +S + LA++ D + +WDL K+ ++ + D L+F Sbjct: 388 FPGHSGPITSIAFSENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 446 Query: 372 G--------------------------HTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 G H+ + ++ + + I S D ++ + + Sbjct: 447 GTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKF-IASTGMDRSLKFYSL 504 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 43/235 (18%), Positives = 95/235 (40%), Gaps = 32/235 (13%) Query: 176 HQKEGYG---LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 H G L P+ + +L+ D + ++D S+ GHT V Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-------QILATLKGHTKKVTS 269 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V +H + +F S + D + IW + + V AH + V LS + +++L++ Sbjct: 270 VVFHPSQDLVF-SASPDATIRIWSVPNASC---VQVVRAHESAVTGLSLHATGDYLLSS- 324 Query: 293 SADKTVALWDLRNLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 S D+ A D++ ++ + + Q+ P I + D ++ +WDL + Sbjct: 325 SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERT 383 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + GH+ I+ +++ N + + + ++D+ +++W + + Sbjct: 384 N--------------VANFPGHSGPITSIAFSENGYY-LATAADDSSVKLWDLRK 423 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 32/214 (14%), Positives = 79/214 (36%), Gaps = 25/214 (11%) Query: 211 PKEGKVVDAKTIFTG-HTAVV---EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 P+E G H+A + + + + D+ ++++D ++ + Sbjct: 201 PEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD---KSSEQIL 257 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 ++ HT +V + F+P + + + S D T+ +W + N + +H+ + + Sbjct: 258 ATLKGHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASC-VQVVRAHESAVTGLSLH 315 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 + +L+SS W S I + D ++P+ Sbjct: 316 ATGDYLLSSSDD----QYWAFSDIQTGRVLTKVTDETSGCSLTCAQ---------FHPDG 362 Query: 387 PWVICSVSEDNIMQVWQMAE--NIYNDEDPEGSV 418 + + + D+ +++W + E N+ N G + Sbjct: 363 -LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPI 395 >2YNP-A nrPDB Length = 604 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 96/275 (34%), Gaps = 45/275 (16%) Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 G+ ++P L + + LW+ + + +T V Sbjct: 9 FSNRSDRVKGIDFHPTEPWVLTTL-YSGRVELWNYETQVEVRSIQVTET-------PVRA 60 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + +DD ++ +++ NT + +AH + ++ +P ++L +G Sbjct: 61 GKFIARKNWIIV-GSDDFRIRVFNY---NTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D TV LW+ N +FE H+ + V ++P + + AS DR + VW L + Sbjct: 116 SDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 353 EQSPEDAEDG-------------------------------PPELLFIHGGHTAKISDFS 381 + ++ + GH + +S Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 382 WNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 ++P P +I S SED +++W + G Sbjct: 236 FHPTLP-IIISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 96/269 (35%), Gaps = 23/269 (8%) Query: 112 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 ++E+ E V +++ + II + + VF+Y D Sbjct: 43 ETQVEVRSIQVTETPVRAGKFIARKNWIIV-GSDDFRIRVFNYNTGEKVVD--------- 92 Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 H ++ +P ++LS SDD T+ LW+ + F GH V Sbjct: 93 -FEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENN------WALEQTFEGHEHFVM 144 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE-FILA 290 V+++ S F S D+ + +W ++ VN + + P + + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 T S D T+ +WD + K + + E H + + P I+ S D L +W+ S Sbjct: 203 TASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTY 260 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISD 379 E++ + + G I+ Sbjct: 261 KVEKTLNVGLERSWCIATHPTGRKNYIAS 289 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 89/245 (36%), Gaps = 22/245 (8%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H + P P ++ + + V ++++ + GH+ Sbjct: 95 AHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNW---------ENNWALEQTFEGHEHFVM 144 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 +++NP S D T+ +W + G+ T+ TG V V ++ L + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSL------GQSTPNFTLTTGQERGVNYVDYYPLPDK 198 Query: 242 LFG-SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + + +DD + IWD ++ + +++ H + V+ F+P I+ +GS D T+ + Sbjct: 199 PYMITASDDLTIKIWDYQTKSC---VATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKI 254 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 W+ K++ + + + P +SG D V L S + Sbjct: 255 WNSSTYKVEKTLNVGLERS-WCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVG 313 Query: 361 DGPPE 365 Sbjct: 314 KLVWS 318 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 75/200 (37%), Gaps = 20/200 (10%) Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 +D K F+ + V+ + +H + ++ ++ +W+ + + + V Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVELWNYETQVEVRSIQVTE---TPV 58 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 F +I+ GS D + +++ N K+ FE+H D I + P +L S Sbjct: 59 RAGKFIARKNWIIV-GSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SG 115 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + +W+ + L GH + ++NP +P S D Sbjct: 116 SDDLTVKLWN-------------WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLD 162 Query: 397 NIMQVWQMAENIYNDEDPEG 416 ++VW + ++ N G Sbjct: 163 RTVKVWSLGQSTPNFTLTTG 182 >5OQL-J nrPDB Length = 912 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 64/346 (18%), Positives = 121/346 (34%), Gaps = 67/346 (19%) Query: 94 DASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFD 153 DA Y + E GS G ++ + HE V + + IA+ + + ++ Sbjct: 405 DAQAYSEDNAECRS-GSYFG-HDVALLKGHEDIVMSLD-VDWSGHWIASGSKDNTARLWR 461 Query: 154 YTKHPSKPDPSGECNP-DLRLRGHQKEGYGLSW-------------NP--NLSGHLLSAS 197 DP+ GH + ++ NP + L+S S Sbjct: 462 V-------DPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGS 514 Query: 198 DDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDT 257 D + DI ++G + + H + + + LF S + D+ + IWD Sbjct: 515 QDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISP-NGKLFASASQDKTVKIWDV 573 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNP-------------YSEFILATGSADKTVALWDLR 304 + + H V + F P ++ TGS DKT+ LW+L Sbjct: 574 E---KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLS 630 Query: 305 NLKLKLHSFESHKDEIFQVQW---SPHN-----ETILASSGTDRRLNVWDLSKIGEEQSP 356 + + +FE H + +V W S + + AS+G D + VWD + E + Sbjct: 631 DYTC-IRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTL 689 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 ++ H ++ + + + ++ S D+ + W Sbjct: 690 DN--------------HEDRLWTLAVHS-KTNILASAGSDSKVTFW 720 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 57/330 (17%), Positives = 117/330 (35%), Gaps = 55/330 (16%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP-------DLRLR 174 E+ Y+ + ++A T S D+ + + + + EC L+ Sbjct: 371 GTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLK 430 Query: 175 GHQKEGYG--LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 GH+ + W+ + + S S D+T LW + +FTGH V Sbjct: 431 GHEDIVMSLDVDWSGHW---IASGSKDNTARLWRVDPAN---NSYTCYAVFTGHLESVGA 484 Query: 233 VSW-------------HL--LHESLFGSVADDQKLMIWDT----RSNNTSKPSHSVDAHT 273 V+ + + S + D+ + D + S AH Sbjct: 485 VALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP------ 327 ++N L +P + + A+ S DKTV +WD+ L+++ HK ++ V+++P Sbjct: 545 KDINALDISPNGK-LFASASQDKTVKIWDVEKLEVQG-ILRGHKRGVWTVRFAPLNTPVI 602 Query: 328 -------HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 380 ++ + D+ + +W+LS ++ E +++++H I+ Sbjct: 603 QGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKT 662 Query: 381 SWNPNEPWVICSVSEDNIMQVWQMAENIYN 410 S D +++VW Sbjct: 663 KVQ------FASAGADTLVKVWDANTGETE 686 Score = 98.3 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 93/269 (34%), Gaps = 35/269 (13%) Query: 169 PDLRLRGHQKEGYGLSW-NPNLSGH-LLSASDDHTICLW--------DISAVPKEGKVVD 218 P R+ G E L++ P+ S + + S+D I D + Sbjct: 365 PFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGH 424 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDT-RSNNTSKPSHSVDAHTAEVN 277 + GH +V + S + D +W +NN+ H V Sbjct: 425 DVALLKGHEDIVMSLDV-DWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVG 483 Query: 278 CLSF-------------NP--YSEFILATGSADKTVALWDLR----NLKLKLHSFE--SH 316 ++ NP + L +GS D+ V D+ S +H Sbjct: 484 AVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAH 543 Query: 317 KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 +I + SP+ + + AS+ D+ + +WD+ K+ + + G + F T Sbjct: 544 DKDINALDISPNGK-LFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLN-TPV 601 Query: 377 ISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 I + + V+ + S D +++W ++ Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLS 630 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 57/366 (15%), Positives = 110/366 (30%), Gaps = 83/366 (22%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H V + + ++AT + ++D SG L + Sbjct: 109 PHATPVVVLA-VDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVT 167 Query: 182 GLSWNPNLSG-------------------HLLSASDDHTICLWDISAVPKEGKVVDAKTI 222 S + N L + D I ++D+ D K Sbjct: 168 AESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRK 227 Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQK------------------------------- 251 H + V+ +++ +L S + D+ Sbjct: 228 KEAHESNVQCIAYSPEQHALL-SGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEG 286 Query: 252 -----------LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 L IWDT +++ + + P IL AD T+ L Sbjct: 287 KWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILC-AQADFTLVL 345 Query: 301 WDLRNLKLKLHSFES------------HKDEIFQVQWSPHNETI--LASSGTD-RRLNVW 345 + + + + S E H DEI + + ++++ +A++ D R ++V Sbjct: 346 YRVPSPADVVSSSEGILLEPFRRISGTH-DEILDLTYILPDQSMMAIATNSEDIRIVSVK 404 Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW--Q 403 D E+ + + + + GH + + + W I S S+DN ++W Sbjct: 405 DAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHW-IASGSKDNTARLWRVD 463 Query: 404 MAENIY 409 A N Y Sbjct: 464 PANNSY 469 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 69/231 (29%), Gaps = 45/231 (19%) Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSH----- 267 E G + ++ L + + I+ + Sbjct: 47 ELNTGKRLAEIQGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVEPTLVR 105 Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327 + H V L+ + S +LATG+AD + +WD+ H+ + + + Sbjct: 106 TTKPHATPVVVLAVDRTS-TLLATGAADGAIKIWDI-IGGYVTHTVSGPSVLVSALHFFE 163 Query: 328 -----------------------HNETILAS------SGTDRRLNVWDLSKIGEEQSPED 358 + +AS D R+ ++DL K D Sbjct: 164 IAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYAD 223 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 + H + + +++P + ++ S S D M +W + I+ Sbjct: 224 PKRKK-------EAHESNVQCIAYSPEQHALL-SGSRDKTMTLWLWRDGIW 266 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 14/118 (11%), Positives = 38/118 (32%), Gaps = 8/118 (6%) Query: 305 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPP 364 N +L + + I + +P ++ + ++ L+ + S E P Sbjct: 49 NTGKRLAEIQGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVE------P 101 Query: 365 ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEG 422 L+ H + + + ++ + + D +++W + SV Sbjct: 102 TLVRTTKPHATPVVVLAVDRTST-LLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSA 158 >2HES-X nrPDB Length = 330 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 103/274 (37%), Gaps = 19/274 (6%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 + I+AT + + + L H+K ++W P+ S Sbjct: 20 FDFSQGILATGSTDRKIKLVSVKY------DDFTLIDVLDETAHKKAIRSVAWRPHTS-L 72 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 L + S D T+ +W +D I GH V+ V+W + + D+ + Sbjct: 73 LAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDG-YYLATCSRDKSV 131 Query: 253 MIWDT-RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW-DLRNLKLKL 310 IW+T S + + H+ +V + ++P SE +LA+ S D TV +W D + + Sbjct: 132 WIWETDESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECV 190 Query: 311 HSFESHKDEIFQVQWSPHNETI-LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 H+ ++ + L S D + VW E+ E + Sbjct: 191 AVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWV-----CEAIL 245 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 H ++ + +W N +I SV D ++ V++ Sbjct: 246 PDVHKRQVYNVAWGFNG--LIASVGADGVLAVYE 277 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 122/303 (40%), Gaps = 32/303 (10%) Query: 114 KIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL 173 I++ + H+ + + P ++A + S V ++ + D + E + + Sbjct: 48 LIDVLDETAHKKAIRSVAWRPHT-SLLAAGSFDSTVSIWAKEE---SADRTFEMDLLAII 103 Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 GH+ E G++W+ N +L + S D ++ +W+ +E + ++ H+ V+ V Sbjct: 104 EGHENEVKGVAWS-NDGYYLATCSRDKSVWIWETDESGEE---YECISVLQEHSQDVKHV 159 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY-SEFILATG 292 WH L S + D + IW ++ + ++ H V F+ F L +G Sbjct: 160 IWHPSEA-LLASSSYDDTVRIW-KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSG 217 Query: 293 SADKTVALW-------DLRNLKLKLHSF-ESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 S D TV +W D + + + HK +++ V W + ++AS G D L V Sbjct: 218 SDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG--LIASVGADGVLAV 275 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW-NPNEPWVICSVSEDNIMQVWQ 403 ++ D E + G +I+ W N ++ + +D I+ W Sbjct: 276 YE---------EVDGEWKVFAKRALCHG-VYEINVVKWLELNGKTILATGGDDGIVNFWS 325 Query: 404 MAE 406 + + Sbjct: 326 LEK 328 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 95/239 (39%), Gaps = 27/239 (11%) Query: 185 WNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF 243 W+ + S G L + S D I L + V +T H + V+W H SL Sbjct: 18 WSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETA---HKKAIRSVAWRP-HTSLL 73 Query: 244 GSVADDQKLMIWDTRSNNTSKPSHS----VDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 + + D + IW + ++ H EV ++++ + LAT S DK+V Sbjct: 74 AAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDG-YYLATCSRDKSVW 132 Query: 300 LWDLRNLKL---KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 +W+ + + H ++ V W P E +LASS D + +W Sbjct: 133 IWETDESGEEYECISVLQEHSQDVKHVIWHPS-EALLASSSYDDTVRIW----------- 180 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV-ICSVSEDNIMQVWQMAENIYNDEDP 414 D E + + GH + ++ E +CS S+D+ ++VW+ + +D+ Sbjct: 181 -KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQE 238 >6QDV-o nrPDB Length = 513 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 92/230 (40%), Gaps = 29/230 (12%) Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 GH K + P LLS S D I LW++ + F GH+ V D+ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR------CLRTFIGHSKAVRDI 272 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP--YSEFILAT 291 ++ F S A D+ L +WDT + + C+ FNP + + Sbjct: 273 CFNTAGTQ-FLSAAYDRYLKLWDTETGQCISRFTN----RKVPYCVKFNPDEDKQNLFVA 327 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW+ Sbjct: 328 GMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTSD-DKSLRVWE----- 380 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 D P + +I + + +PN W+ C S DN + + Sbjct: 381 --------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQ-SMDNQILI 421 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 113/337 (33%), Gaps = 86/337 (25%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 +I + H V+ R P + ++ + + + +++ GE G Sbjct: 214 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV---------YGERRCLRTFIG 264 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H K + +N LSA+ D + LWD + + FT + V V + Sbjct: 265 HSKAVRDICFN-TAGTQFLSAAYDRYLKLWD-------TETGQCISRFT-NRKVPYCVKF 315 Query: 236 HLLHE--SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 + + +LF + D+K++ WD RS + D H VN + F + ++T S Sbjct: 316 NPDEDKQNLFVAGMSDKKIVQWDIRSG---EIVQEYDRHLGAVNTIVFVDENRRFVST-S 371 Query: 294 ADKTVALWDL-----------------------RNLKL---------------------- 308 DK++ +W+ N K Sbjct: 372 DDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLN 431 Query: 309 KLHSFESH--KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 K F+ H QV +SP ++ S + +LN+WD +L Sbjct: 432 KKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTT--------------KL 476 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 H W+P+E + + D ++++W Sbjct: 477 YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 94.5 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 63/172 (36%), Gaps = 32/172 (18%) Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 322 K H HT V+ + P S +L + S D + LW++ + L +F H + Sbjct: 212 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 271 Query: 323 VQWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPEDAEDGPP------------ 364 + ++ L S+ DR L +WD +S+ + P + P Sbjct: 272 ICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMS 330 Query: 365 ------------ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 E++ + H ++ + +E S S+D ++VW+ Sbjct: 331 DKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEW 381 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 38/102 (37%), Gaps = 14/102 (13%) Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 K ++H + H + V+ P + +L S D ++ +W++ G Sbjct: 211 PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-------------YGERR 257 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 L GH+ + D +N + S + D +++W Sbjct: 258 CLRTFIGHSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETG 298 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%) Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 D+ P + P + + + GHT +S P ++ S S D +++W++ Sbjct: 194 DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 253 Query: 406 E 406 Sbjct: 254 G 254 >3JB9-g nrPDB Length = 558 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 50/236 (21%), Positives = 90/236 (38%), Gaps = 29/236 (12%) Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 +GH K L + P LLS S D+ I +W++ F GH + D+ Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDR------SLLRTFQGHARPIRDL 316 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN--PYSEFILAT 291 S+ S F S + D+ + +WDT +S NC+ F P Sbjct: 317 SFSQDGRS-FLSTSFDKTIKLWDTELGKCLNCFNS----DRLTNCVKFQVDPDKPNEFLA 371 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 G+ADK + +D+R+ + + +++ H I + + + + + +S D + W+ Sbjct: 372 GTADKRILQFDIRSPDI-VQAYDHHLGGINSITFLENGKRFVTTSD-DSSMRFWEYGT-- 427 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 P + F+ + + PN + C S DN + V+ E Sbjct: 428 -----------PVPIKFVADIAMHSMPRVALRPNGKSIACQ-SLDNCIYVYSAYEK 471 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 47/324 (14%), Positives = 102/324 (31%), Gaps = 71/324 (21%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H ++ R+ P + ++ + + + + +++ S +GH + Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL---------RTFQGHARPIR 314 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAV------------------------------- 210 LS++ + LS S D TI LWD Sbjct: 315 DLSFSQD-GRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 211 ------PKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK 264 + + D + H + +++ L + F + +DD + W+ + K Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHLGGINSITF-LENGKRFVTTSDDSSMRFWEYGTPVPIK 432 Query: 265 PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW----DLRNLKLKLHSFESHKDEI 320 + H+ ++ P + I S D + ++ R K K+ S Sbjct: 433 FVADIAMHSMP--RVALRPNGKSIACQ-SLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYS 489 Query: 321 FQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 380 +V +SP + S + WD +L+ H+ + Sbjct: 490 LEVGFSPDGRFVF-SGDSSGNACFWDWKTC--------------KLMAKLPAHSGPVQSM 534 Query: 381 SWNPNEPWVICSVS-EDNIMQVWQ 403 +++P E + + S D ++ W Sbjct: 535 AFHPQETSKVATSSIVDGSIKYWD 558 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 32/175 (18%), Positives = 71/175 (40%), Gaps = 34/175 (19%) Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 322 K + HT ++CL F P S +L +GS D + +W++ + + L +F+ H I Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRD 315 Query: 323 VQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF-------------- 368 + +S + L++S D+ + +WD +++G+ + +++ + F Sbjct: 316 LSFSQDGRSFLSTS-FDKTIKLWD-TELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 369 -----------------IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + H I+ ++ N + S+D+ M+ W+ Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKR-FVTTSDDSSMRFWEYGT 427 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 43/220 (19%), Positives = 78/220 (35%), Gaps = 28/220 (12%) Query: 87 PNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHE-GEVNRARYMPQNPCIIATKTP 145 P+ +F A D +F +I +H G +N ++ +N T + Sbjct: 363 PDKPNEFLAGTADKRILQFDIRSP-----DIVQAYDHHLGGINSITFL-ENGKRFVTTSD 416 Query: 146 SSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW 205 S + ++Y P P + H ++ PN + S D+ I ++ Sbjct: 417 DSSMRFWEY----GTPVPI---KFVADIAMHS--MPRVALRPNGKS-IACQSLDNCIYVY 466 Query: 206 DISAVPKEGKVVDAKTIFTGHTAVVED--VSWHLLHESLFGSVADDQKLMIWDTRSNNTS 263 ++ K K +F G++ V + +F S WD T Sbjct: 467 SAYEKYRQNK----KKVFKGYSCSGYSLEVGFSPDGRFVF-SGDSSGNACFWD---WKTC 518 Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGS-ADKTVALWD 302 K + AH+ V ++F+P +AT S D ++ WD Sbjct: 519 KLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 32/75 (42%) Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 D+ E+ E P + +F GHT IS + P ++ S S DN +++W++ Sbjct: 238 DVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVY 297 Query: 406 ENIYNDEDPEGSVDP 420 + +G P Sbjct: 298 HDRSLLRTFQGHARP 312 >5YZG-W nrPDB Length = 579 Score = 134 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 92/230 (40%), Gaps = 29/230 (12%) Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 GH K + P LLS S D I LW++ + F GH+ V D+ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERR------CLRTFIGHSKAVRDI 338 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP--YSEFILAT 291 ++ F S A D+ L +WDT + + C+ FNP + + Sbjct: 339 CFNTAGTQ-FLSAAYDRYLKLWDTETGQCISRFTN----RKVPYCVKFNPDEDKQNLFVA 393 Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 G +DK + WD+R+ ++ + ++ H + + + N +++S D+ L VW+ Sbjct: 394 GMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENRRFVSTSD-DKSLRVWE----- 446 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 D P + +I + + +PN W+ C S DN + + Sbjct: 447 --------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQ-SMDNQILI 487 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 113/337 (33%), Gaps = 86/337 (25%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 175 +I + H V+ R P + ++ + + + +++ GE G Sbjct: 280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV---------YGERRCLRTFIG 330 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H K + +N LSA+ D + LWD + + FT + V V + Sbjct: 331 HSKAVRDICFN-TAGTQFLSAAYDRYLKLWD-------TETGQCISRFT-NRKVPYCVKF 381 Query: 236 HLLHE--SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 + + +LF + D+K++ WD RS + D H VN + F + ++T S Sbjct: 382 NPDEDKQNLFVAGMSDKKIVQWDIRSG---EIVQEYDRHLGAVNTIVFVDENRRFVST-S 437 Query: 294 ADKTVALWDL-----------------------RNLKL---------------------- 308 DK++ +W+ N K Sbjct: 438 DDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLN 497 Query: 309 KLHSFESH--KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 K F+ H QV +SP ++ S + +LN+WD +L Sbjct: 498 KKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTT--------------KL 542 Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 H W+P+E + + D ++++W Sbjct: 543 YSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 94.5 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 63/172 (36%), Gaps = 32/172 (18%) Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 322 K H HT V+ + P S +L + S D + LW++ + L +F H + Sbjct: 278 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRD 337 Query: 323 VQWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPEDAEDGPP------------ 364 + ++ L S+ DR L +WD +S+ + P + P Sbjct: 338 ICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMS 396 Query: 365 ------------ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 E++ + H ++ + +E S S+D ++VW+ Sbjct: 397 DKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEW 447 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 38/102 (37%), Gaps = 14/102 (13%) Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 K ++H + H + V+ P + +L S D ++ +W++ G Sbjct: 277 PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-------------YGERR 323 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 L GH+ + D +N + S + D +++W Sbjct: 324 CLRTFIGHSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETG 364 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%) Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 D+ P + P + + + GHT +S P ++ S S D +++W++ Sbjct: 260 DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVY 319 Query: 406 E 406 Sbjct: 320 G 320 >5L9T-R nrPDB Length = 493 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 101/258 (39%), Gaps = 29/258 (11%) Query: 100 SEKGEFGGFGSVSGKIEIEIKINH------EGEVNRARYMPQNPCIIATKTPSSDVLVFD 153 SE+G G+ G ++I EG R + N +++ + +L D Sbjct: 238 SERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRD 297 Query: 154 YTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKE 213 P + + RL+GH++E GL W+ + L S +D+ + +W+ S+ Sbjct: 298 IRTPPLQ--------SERRLQGHRQEVCGLKWSTDH-QLLASGGNDNKLLVWNHSS---- 344 Query: 214 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD--DQKLMIWDTRSNNTSKPSHSVDA 271 + +T H A V+ ++W L S D+ + W+T + +P +D Sbjct: 345 ---LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG---QPLQCIDT 398 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 331 + N +E + G + + +W +L ++ H + + SP E Sbjct: 399 GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSL-TQVAKLTGHSYRVLYLAMSPDGEA 457 Query: 332 ILASSGTDRRLNVWDLSK 349 I+ +G D L W++ Sbjct: 458 IVTGAG-DETLRFWNVFS 474 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 55/312 (17%), Positives = 118/312 (37%), Gaps = 44/312 (14%) Query: 112 SGKIEIEIKINHEGE-VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPD 170 + ++ ++ EG+ V + + ++A T V ++D Sbjct: 216 TSQVTRLCDLSVEGDSVTSVGW-SERGNLVAVGTHKGFVQIWDAAAGKKLS--------- 265 Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 L GH L+WN L S S D I DI P + ++ GH V Sbjct: 266 -MLEGHTARVGALAWNAE---QLSSGSRDRMILQRDIRTPP-----LQSERRLQGHRQEV 316 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 + W H+ L S +D KL++W+ +++ P H A V ++++P+ +LA Sbjct: 317 CGLKWSTDHQ-LLASGGNDNKLLVWN---HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA 372 Query: 291 TGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT-DRRLNVWDL 347 +G AD+ + W+ + ++ + WS H ++++ G ++ VW Sbjct: 373 SGGGTADRCIRFWNTLTGQPLQCIDTG--SQVCNLAWSKHANELVSTHGYSQNQILVWKY 430 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + + GH+ ++ + +P+ I + + D ++ W + Sbjct: 431 PSLTQVAKL--------------TGHSYRVLYLAMSPDG-EAIVTGAGDETLRFWNVFSK 475 Query: 408 IYNDEDPEGSVD 419 + ++ ++ Sbjct: 476 TRSTKESVSVLN 487 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 88/228 (38%), Gaps = 33/228 (14%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + W+ S ++LS + LW G V V W +L Sbjct: 193 VDWS---SLNVLSVGLGTCVYLWSACTSQV---TRLCDLSVEG--DSVTSVGWSERG-NL 243 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 + IWD + K ++ HTA V L++N L++GS D+ + D Sbjct: 244 VAVGTHKGFVQIWDAAAG---KKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRD 297 Query: 303 LRNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 +R L+ + H+ E+ ++WS ++ +LAS G D +L VW+ S + Q + Sbjct: 298 IRTPPLQSERRLQGHRQEVCGLKWSTDHQ-LLASGGNDNKLLVWNHSSLSPVQQYTE--- 353 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVS--EDNIMQVWQMAEN 407 H A + +W+P++ ++ S D ++ W Sbjct: 354 -----------HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG 390 >5WLC-LO nrPDB Length = 923 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 105/251 (41%), Gaps = 18/251 (7%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP-DLRLRGHQKEGYGLSWNPNLSG 191 M QNP + + + L F +K + L+ +GH L+++P+ S Sbjct: 300 MGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGS- 358 Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +++AS+D I +WDI++ F HT+ V V + + +F S + D Sbjct: 359 RVVTASEDGKIKVWDITSG-------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLDGT 410 Query: 252 LMIWDTRSNNTSKPSHSVDAHTA-EVNCLSFNPYSEFILATGSADK-TVALWDLRNLKLK 309 + WD + + + NCL+ +P E ++ GS D + +W ++ +L Sbjct: 411 VRAWDL---IRYRNFRTFTGTERIQFNCLAVDPSGE-VVCAGSLDNFDIHVWSVQTGQL- 465 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 L + H+ + + +S N ++LAS+ D+ + +W + ++ P + L Sbjct: 466 LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMR 524 Query: 370 HGGHTAKISDF 380 G +S Sbjct: 525 PDGKEVAVSTL 535 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 60/367 (16%), Positives = 121/367 (32%), Gaps = 63/367 (17%) Query: 88 NDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSS 147 + D++F + + S + H V A + + I T + Sbjct: 155 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA-FFSHDQEKIYTVSKDG 213 Query: 148 DVLVFDYTKHP------------SKPDPSGECNPDLRLRGH-----QKEGYGLSWNPNLS 190 V V+++TK P + + + H Q + ++++P + Sbjct: 214 AVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-AT 272 Query: 191 GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQ 250 L L+D+ + + G V VS + E L + Sbjct: 273 RLLAVGFTSGEFRLYDL------PDFTLIQQLSMG-QNPVNTVSVNQTGEWLAFGSSKLG 325 Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310 +L++++ +S + H N L+++P + T S D + +WD+ + L Sbjct: 326 QLLVYEWQSESY---ILKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSG-FCL 380 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI- 369 +FE H + VQ++ + + SS D + WDL + ++ E L + Sbjct: 381 ATFEEHTSSVTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 439 Query: 370 -----------------------------HGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 GH +S S++ E V+ S S D ++ Sbjct: 440 PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIR 498 Query: 401 VWQMAEN 407 +W + Sbjct: 499 IWSIFGR 505 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 99/276 (35%), Gaps = 47/276 (17%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 GH ++ L+W+ + S +L+ S D + +W + + K A T F GH V Sbjct: 140 RVHAGHFQDITSLTWSQD-SRFILTTSKDLSAKIWSVDSEEKN----LAATTFNGHRDYV 194 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDT------------------------RSNNTSKPS 266 ++ + +V+ D + +W+ + + Sbjct: 195 MG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 253 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 H A+ A+V C++F+P + +LA G L+DL + L + ++ + V + Sbjct: 254 HFFYANQAKVKCVTFHPATR-LLAVGFTSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVN 311 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 E + S +L V+ E + GH + +++P+ Sbjct: 312 QTGEWLAFGSSKLGQLLVY--------------EWQSESYILKQQGHFDSTNSLAYSPDG 357 Query: 387 PWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEG 422 V+ + SED ++VW + E + Sbjct: 358 SRVV-TASEDGKIKVWDITSGFCLATFEEHTSSVTA 392 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 70/175 (40%), Gaps = 18/175 (10%) Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +++ + L V ++ ++D +N + + H + + N +++ Sbjct: 20 ITFSDDGKQLLSPVG--NRVSVFDLINNKSFTFEYE---HRKNIAAIDLNKQGTLLISID 74 Query: 293 SADKTVAL-WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 + + + + RN + + K++ V++SP +SG R L +W Sbjct: 75 EDGRAILVNFKARN----VLHHFNFKEKCSAVKFSPDGRLFALASG--RFLQIW-----K 123 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 +D + P +H GH I+ +W+ + +++ + S+D ++W + Sbjct: 124 TPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFIL-TTSKDLSAKIWSVDS 177 >4LG8-A nrPDB Length = 354 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 111/299 (37%), Gaps = 51/299 (17%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 P + I T +V+VFD + L+GH K+ + ++P+ Sbjct: 80 CPSDTNKILTGGADKNVVVFDKSSEQIL----------ATLKGHTKKVTSVVFHPSQD-L 128 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 + SAS D TI +W + + H + V +S H + L S +DDQ Sbjct: 129 VFSASPDATIRIWSVPNAS-------CVQVVRAHESAVTGLSLHATGDYLL-SSSDDQYW 180 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312 D ++ + + + C F+P I TG+ D + +WDL+ + + + Sbjct: 181 AFSDIQTGRVLTKV-TDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLK-ERTNVAN 237 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE-DAEDGPPELLFIHG 371 F H I + +S + LA++ D + +WDL K+ ++ + D L+F Sbjct: 238 FPGHSGPITSIAFSENG-YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQS 296 Query: 372 G--------------------------HTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 G H+ + ++ + + I S D ++ + + Sbjct: 297 GTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKF-IASTGMDRSLKFYSL 354 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 43/235 (18%), Positives = 95/235 (40%), Gaps = 32/235 (13%) Query: 176 HQKEGYG---LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 H G L P+ + +L+ D + ++D S+ GHT V Sbjct: 67 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-------QILATLKGHTKKVTS 119 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 V +H + +F S + D + IW + + V AH + V LS + +++L++ Sbjct: 120 VVFHPSQDLVF-SASPDATIRIWSVPNASC---VQVVRAHESAVTGLSLHATGDYLLSS- 174 Query: 293 SADKTVALWDLRNLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 S D+ A D++ ++ + + Q+ P I + D ++ +WDL + Sbjct: 175 SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERT 233 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + GH+ I+ +++ N + + + ++D+ +++W + + Sbjct: 234 N--------------VANFPGHSGPITSIAFSENGYY-LATAADDSSVKLWDLRK 273 Score = 94.5 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 32/214 (14%), Positives = 79/214 (36%), Gaps = 25/214 (11%) Query: 211 PKEGKVVDAKTIFTG-HTAVV---EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 P+E G H+A + + + + D+ ++++D ++ + Sbjct: 51 PEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD---KSSEQIL 107 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 ++ HT +V + F+P + + + S D T+ +W + N + +H+ + + Sbjct: 108 ATLKGHTKKVTSVVFHPSQDLVF-SASPDATIRIWSVPNASC-VQVVRAHESAVTGLSLH 165 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 + +L+SS W S I + D ++P+ Sbjct: 166 ATGDYLLSSSDD----QYWAFSDIQTGRVLTKVTDETSGCSLTCAQ---------FHPDG 212 Query: 387 PWVICSVSEDNIMQVWQMAE--NIYNDEDPEGSV 418 + + + D+ +++W + E N+ N G + Sbjct: 213 -LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPI 245 >5I2T-A nrPDB Length = 742 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 105/251 (41%), Gaps = 18/251 (7%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP-DLRLRGHQKEGYGLSWNPNLSG 191 M QNP + + + L F +K + L+ +GH L+++P+ S Sbjct: 325 MGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGS- 383 Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +++AS+D I +WDI++ F HT+ V V + + +F S + D Sbjct: 384 RVVTASEDGKIKVWDITSG-------FCLATFEEHTSSVTAVQFAKRGQVMF-SSSLDGT 435 Query: 252 LMIWDTRSNNTSKPSHSVDAHTA-EVNCLSFNPYSEFILATGSADK-TVALWDLRNLKLK 309 + WD + + + NCL+ +P E ++ GS D + +W ++ +L Sbjct: 436 VRAWDL---IRYRNFRTFTGTERIQFNCLAVDPSGE-VVCAGSLDNFDIHVWSVQTGQL- 490 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 L + H+ + + +S N ++LAS+ D+ + +W + ++ P + L Sbjct: 491 LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMR 549 Query: 370 HGGHTAKISDF 380 G +S Sbjct: 550 PDGKEVAVSTL 560 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 121/367 (32%), Gaps = 63/367 (17%) Query: 88 NDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSS 147 + D++F + + S + H V A + + I T + Sbjct: 180 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA-FFSHDQEKIYTVSKDG 238 Query: 148 DVLVFDYTKHP------------SKPDPSGECNPDLRLRGH-----QKEGYGLSWNPNLS 190 V V+++TK P + + + H Q + ++++P + Sbjct: 239 AVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-AT 297 Query: 191 GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQ 250 L L+D+ ++ + V VS + E L + Sbjct: 298 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQ-------NPVNTVSVNQTGEWLAFGSSKLG 350 Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 310 +L++++ +S + H N L+++P + T S D + +WD+ + L Sbjct: 351 QLLVYEWQSESY---ILKQQGHFDSTNSLAYSPDGS-RVVTASEDGKIKVWDITSG-FCL 405 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI- 369 +FE H + VQ++ + + SS D + WDL + ++ E L + Sbjct: 406 ATFEEHTSSVTAVQFAKRGQVMF-SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 464 Query: 370 -----------------------------HGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 GH +S S++ E V+ S S D ++ Sbjct: 465 PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIR 523 Query: 401 VWQMAEN 407 +W + Sbjct: 524 IWSIFGR 530 Score = 101 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 98/276 (35%), Gaps = 47/276 (17%) Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 GH ++ L+W+ + S +L+ S D + +W + + K A T F GH V Sbjct: 165 RVHAGHFQDITSLTWSQD-SRFILTTSKDLSAKIWSVDSEEKN----LAATTFNGHRDYV 219 Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDT------------------------RSNNTSKPS 266 ++ + +V+ D + +W+ + + Sbjct: 220 MG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 278 Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 H A+ A+V C++F+P + +LA G L+DL + L ++ + V + Sbjct: 279 HFFYANQAKVKCVTFHPATR-LLAVGFTSGEFRLYDLPDFTLIQQLSMG-QNPVNTVSVN 336 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 E + S +L V+ E + GH + +++P+ Sbjct: 337 QTGEWLAFGSSKLGQLLVY--------------EWQSESYILKQQGHFDSTNSLAYSPDG 382 Query: 387 PWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEG 422 V+ + SED ++VW + E + Sbjct: 383 SRVV-TASEDGKIKVWDITSGFCLATFEEHTSSVTA 417 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 70/175 (40%), Gaps = 18/175 (10%) Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +++ + L V ++ ++D +N + + H + + N +++ Sbjct: 45 ITFSDDGKQLLSPVG--NRVSVFDLINNKSFTFEYE---HRKNIAAIDLNKQGTLLISID 99 Query: 293 SADKTVAL-WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 + + + + RN + + K++ V++SP +SG R L +W Sbjct: 100 EDGRAILVNFKARN----VLHHFNFKEKCSAVKFSPDGRLFALASG--RFLQIW-----K 148 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 +D + P +H GH I+ +W+ + +++ + S+D ++W + Sbjct: 149 TPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFIL-TTSKDLSAKIWSVDS 202 >4AEZ-A nrPDB Length = 401 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 111/293 (37%), Gaps = 32/293 (10%) Query: 88 NDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIA 141 D++ + AS S G F G +G ++I + G R + N +++ Sbjct: 131 TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLS 190 Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + + S + D + L+GH E GL+W + L S +D+ Sbjct: 191 SGSRSGAIHHHDVRIANHQ---------IGTLQGHSSEVCGLAW-RSDGLQLASGGNDNV 240 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD--DQKLMIWDTRS 259 + +WD + K T H A V+ V+W +L + D+++ W+ + Sbjct: 241 VQIWDARSS-------IPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAAT 293 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT-GSADKTVALWDLRNLKLKLHS-FESHK 317 + ++V L ++P+S+ I++T G D +++W + L +H Sbjct: 294 GARVNTVDA----GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHD 349 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 + SP IL+++ +D L W + + P P + I Sbjct: 350 TRVLYSALSPDGR-ILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSITIR 401 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 116/297 (39%), Gaps = 42/297 (14%) Query: 112 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 SG + + + V ++ + ++ + V ++D Sbjct: 122 SGSVSALAETDESTYVASVKW-SHDGSFLSVGLGNGLVDIYDVES----------QTKLR 170 Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 + GHQ LSWN + L S S I D+ + GH++ V Sbjct: 171 TMAGHQARVGCLSWNRH---VLSSGSRSGAIHHHDVRIANHQIG------TLQGHSSEVC 221 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 ++W S +D + IWD RS S P + H A V +++ P+ +LAT Sbjct: 222 GLAWRSDGLQ-LASGGNDNVVQIWDARS---SIPKFTKTNHNAAVKAVAWCPWQSNLLAT 277 Query: 292 GS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT-DRRLNVWDLS 348 G DK + W+ ++++ ++ ++ + WSPH++ I+++ G D L++W S Sbjct: 278 GGGTMDKQIHFWNAATGA-RVNTVDA-GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYS 335 Query: 349 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 G + + H ++ + +P+ ++ + + D ++ W++ Sbjct: 336 SSGLTKQVDIP------------AHDTRVLYSALSPDGR-ILSTAASDENLKFWRVY 379 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 40/218 (18%), Positives = 76/218 (34%), Gaps = 30/218 (13%) Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN 261 + +W+ + ++ + V V W S + + I+D S Sbjct: 115 VYVWNADSGSVSALAETDESTY------VASVKWS-HDGSFLSVGLGNGLVDIYDVESQ- 166 Query: 262 TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321 ++ H A V CLS+N +L++GS + D+R ++ + + H E+ Sbjct: 167 --TKLRTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVC 221 Query: 322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS 381 + W + LAS G D + +WD + F H A + + Sbjct: 222 GLAWR-SDGLQLASGGNDNVVQIWDARSSIPK--------------FTKTNHNAAVKAVA 266 Query: 382 WNPNEPWVICSVS--EDNIMQVWQMAENIYNDEDPEGS 417 W P + ++ + D + W A + GS Sbjct: 267 WCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGS 304 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 18/152 (11%), Positives = 55/152 (36%), Gaps = 29/152 (19%) Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 +S + + ++ V +W+ + + + + V+WS H+ + L+ + ++ Sbjct: 101 WSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWS-HDGSFLSVGLGNGLVD 159 Query: 344 VWDLSKIGEEQSPEDAEDG---------------------------PPELLFIHGGHTAK 376 ++D+ + ++ + + GH+++ Sbjct: 160 IYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSE 219 Query: 377 ISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 + +W + + S DN++Q+W +I Sbjct: 220 VCGLAWRSDGLQ-LASGGNDNVVQIWDARSSI 250 >5WLC-LU nrPDB Length = 489 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 113/341 (33%), Gaps = 88/341 (25%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 H V + +AT + + ++ + + + H Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMST----------REEFVSFKAHYGLV 113 Query: 181 YGL-----SWNPNLS-----GHLLSASDDHTICLWDI--------------SAVPKEG-- 214 GL ++ +LS SDD T+ LW I S +EG Sbjct: 114 TGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLI 173 Query: 215 KVVDAKTIFTG---HT--------------------AVVEDVSW----------HLLHES 241 + D ++ F G H V D+SW + Sbjct: 174 RTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETD 233 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 + S D ++++D R+N+ ++ T N + +NP F T + D + Sbjct: 234 ILASTGSDNSIVLYDLRTNSPTQKI----VQTMRTNAICWNPMEAFNFVTANEDHNAYYY 289 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 D+RNL L+ F+ H + V +SP + I+ + D+ + ++ + + Sbjct: 290 DMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYKTNHGHSREI------ 342 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 H + ++ + ++I S S+D +++W Sbjct: 343 -------YHTKRMQHVFQVKYSMDSKYII-SGSDDGNVRLW 375 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 96/271 (35%), Gaps = 54/271 (19%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH+ Y ++ N L + S D I W++S + F H +V + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE-------FVSFKAHYGLVTGLC 117 Query: 235 WHLL----------HESLFGSVADDQKLMIWDTRSNNTSKP--------------SHSVD 270 ++ S +DD+ + +W ++ S + D Sbjct: 118 VTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFD 177 Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 330 +A + + + ATG A + LWD+ N + D I ++++ + Sbjct: 178 GESAF-QGIDSHRENST-FATGGA--KIHLWDV-NRLKPVSDLSWGADNITSLKFNQNET 232 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 390 ILAS+G+D + ++DL Q T + + WNP E + Sbjct: 233 DILASTGSDNSIVLYDLRTNSPTQKIV---------------QTMRTNAICWNPMEAFNF 277 Query: 391 CSVSEDNIMQVWQ---MAENIYNDEDPEGSV 418 + +ED+ + ++ ++ +D +V Sbjct: 278 VTANEDHNAYYYDMRNLSRSLNVFKDHVSAV 308 >6J6H-n nrPDB Length = 455 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 46/228 (20%), Positives = 94/228 (41%), Gaps = 28/228 (12%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH + L + P +LS +DHTI +WD + F GH ++ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD------YECLRDFQGHNKPIKALR 213 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + +S F S + D+ + IWDT + H +++ A+V NP+ G + Sbjct: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPHE---FIVGLS 268 Query: 295 DKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 + + +D R + + +++ H I +++ P + SS D+ + +W Sbjct: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI-SSSEDKTVRIW------- 320 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 E+ + P + + H+ + +P++ + C+ S DN + Sbjct: 321 ----ENQINVPIKQISDTAQHSMPFLNV--HPSQNY-FCAQSMDNRIY 361 Score = 94.9 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 49/306 (16%), Positives = 101/306 (33%), Gaps = 38/306 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H +++P+ +I + + ++D+ EC D +GH K Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH-------DYECLRD--FQGHNKPIK 210 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 L + + LS+S D ++ +WD + ++ T DV + Sbjct: 211 ALRFTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLHLNSTP--------ADVESRPTNPH 261 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 F + K++ +D R + + D H + + L + P +++ S DKTV +W Sbjct: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS-SEDKTVRIW 320 Query: 302 D--LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 + + ++ H V S + + D R+ S Sbjct: 321 ENQINVPIKQISDTAQHSMPFLNVHPS---QNYFCAQSMDNRI-----------YSFSLK 366 Query: 360 EDGPPELLFIHGGHTAKIS--DFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 I GH++ +++ + + ICS + + W + + Sbjct: 367 PKYKRHPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 Query: 418 VDPEGQ 423 P Q Sbjct: 426 NKPITQ 431 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 70/201 (34%), Gaps = 20/201 (9%) Query: 206 DISAVPKEGKVVDAKTI---FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNT 262 D+ + K + + GH + + L S +D + IWD + Sbjct: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHD 195 Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 322 + H + L F + L++ S D++V +WD K+K + Sbjct: 196 YECLRDFQGHNKPIKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNSTPA--D 252 Query: 323 VQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 V+ P N ++ ++ +D D L+ + H + I + Sbjct: 253 VESRPTNPHEFIVGLSNSKILHYD-----------DRVSENQGLVQTYDHHLSSILALKY 301 Query: 383 NPNEPWVICSVSEDNIMQVWQ 403 P+ I S SED +++W+ Sbjct: 302 FPDGSKFI-SSSEDKTVRIWE 321 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 34/102 (33%), Gaps = 14/102 (13%) Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 K + ++ H + +++ P ++ S G D + +WD E Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-------------YE 197 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 L GH I + + + S S D +++W Sbjct: 198 CLRDFQGHNKPIKALRFTEDCQSFL-SSSFDRSVKIWDTETG 238 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 26/183 (14%), Positives = 60/183 (32%), Gaps = 20/183 (10%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 +H + +Y P + + + V +++ + S Q Sbjct: 291 HHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDTA---------QHSMP 340 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 L+ +P+ + + S D+ I S K K IF GH++ +S + Sbjct: 341 FLNVHPSQ-NYFCAQSMDNRI----YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 Query: 242 LFGSVADDQKLMI--WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 + + D K + WD ++ + + + + ++P + A + Sbjct: 396 RYI-CSGDSKSRLFTWDWNTSRLLN-NIKIPG-NKPITQVDWHPQETSKVICSGAAGKIY 452 Query: 300 LWD 302 + D Sbjct: 453 VCD 455 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 28/75 (37%) Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 D+ E+ P +++ + GH + + P +I S D+ +++W Sbjct: 134 DVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY 193 Query: 406 ENIYNDEDPEGSVDP 420 + D +G P Sbjct: 194 HDYECLRDFQGHNKP 208 >5FA5-B nrPDB Length = 367 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 93/224 (41%), Gaps = 21/224 (9%) Query: 119 IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 K H+ V+ + + + + + V+D + R H Sbjct: 145 CKYEHDDIVSTVSVLS-SGTQAVSGSKDICIKVWDL----------AQQVVLSSYRAHAA 193 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 + ++ +P+ LS S+D+ I LWD + PK + + ++WH Sbjct: 194 QVTCVAASPHKDSVFLSCSEDNRILLWD-TRCPKPASQIGCSAP----GYLPTSLAWHPQ 248 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 +F ++ + + DT+S + S H+ V L F+P+S LA+ S D ++ Sbjct: 249 QSEVFVFGDENGTVSLVDTKSTSCVLSSA---VHSQCVTGLVFSPHSVPFLASLSEDCSL 305 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 A+ D + +L ++H+D + WSP N ++L + G D ++ Sbjct: 306 AVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 104/276 (37%), Gaps = 33/276 (11%) Query: 124 EGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL 183 E V ++ + ++A+ + V +++ ++ + H + Sbjct: 105 EAGVADLTWVGERGILVASDS--GAVELWELDENETL------IVSKFCKYEHDDIVSTV 156 Query: 184 SWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF 243 S + +S S D I +WD++ + + H A V V+ +S+F Sbjct: 157 SVL-SSGTQAVSGSKDICIKVWDLAQQVV-------LSSYRAHAAQVTCVAASPHKDSVF 208 Query: 244 GSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 S ++D ++++WDTR + A L+++P + G + TV+L D Sbjct: 209 LSCSEDNRILLWDTRCPKPASQI-GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDT 267 Query: 304 RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP 363 ++ L S H + + +SPH+ LAS D L V D Sbjct: 268 KSTSCVLSS-AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD---------------SS 311 Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 399 LF H + D +W+P ++ +V D+ + Sbjct: 312 LSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 91.0 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 86/245 (35%), Gaps = 26/245 (10%) Query: 162 DPSGECNPDLRLRG--HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 DP N G + L+W +L ASD + LW++ + ++ + Sbjct: 88 DPCAAPNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELWELD---ENETLIVS 142 Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279 K H +V VS S + D + +WD S AH A+V C+ Sbjct: 143 KFCKYEHDDIVSTVSVLSSGTQAV-SGSKDICIKVWDLAQQVV---LSSYRAHAAQVTCV 198 Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEI-FQVQWSPHNETILASSGT 338 + +P+ + + + S D + LWD R K S + + W P + Sbjct: 199 AASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDE 258 Query: 339 DRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 + +++ D + H+ ++ ++P+ + S+SED Sbjct: 259 NGTVSLVDTKSTS--------------CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCS 304 Query: 399 MQVWQ 403 + V Sbjct: 305 LAVLD 309 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 68/180 (37%), Gaps = 17/180 (9%) Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD-AHTAEVNCLSFNPYSE 286 A V D++W + E +D + +W+ N T S H V+ +S Sbjct: 106 AGVADLTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGT 163 Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 + +GS D + +WDL ++ L S+ +H ++ V SPH +++ S D R+ +WD Sbjct: 164 QAV-SGSKDICIKVWDLA-QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + G + +W+P + V E+ + + Sbjct: 222 TRCPKPASQIGCSAPGYLP------------TSLAWHPQQSEVFVFGDENGTVSLVDTKS 269 Score = 58.3 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 55/179 (30%), Gaps = 43/179 (24%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTK---------------------HPSK 160 H +V P + + + + +L++D HP + Sbjct: 190 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 249 Query: 161 PD--------------PSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD 206 + + + L H + GL ++P+ L S S+D ++ + D Sbjct: 250 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Query: 207 ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKP 265 + H V D +W L+ SL +V D +++ + P Sbjct: 310 --------SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAP 360 >5FVM-C nrPDB Length = 303 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 48/250 (19%), Positives = 98/250 (39%), Gaps = 33/250 (13%) Query: 163 PSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTI 222 S NP GH+ +++ + ++S+S+D TI +WD+ + + Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRSPSVQRNYK----- 114 Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 H A V +V+ H L S D + IWD N + D + LS Sbjct: 115 ---HNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPED--NTPLQSLSVA 168 Query: 283 PYSEFILATGSADKTVALWDLRNLK-----LKLHSFESHKDEIFQVQWSPHNETILASSG 337 ++A G+ +W + + + F+SH I +V S + LA+ Sbjct: 169 SDGSMLVA-GNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCS 226 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 D VW++ + ++ D GH + D +++ + +++ + S D+ Sbjct: 227 ADHTARVWNIEDNYQLETTLD-------------GHQRWVWDCAFSADSAYLVTACS-DH 272 Query: 398 IMQVWQMAEN 407 +++W ++ + Sbjct: 273 YVRLWDLSTS 282 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 40/178 (22%), Positives = 76/178 (42%), Gaps = 24/178 (13%) Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 + S D + W+ + S+ D+ +VN L +++ A G V Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADS---QVNRLEITSDKKYLAAAGHLH--VR 56 Query: 300 LWDLR-NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 L+D+R N + SFE HK + + + N ++ SS D + VWD+ +++ + Sbjct: 57 LYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMV-SSSEDGTIKVWDVRSPSVQRNYK- 114 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN-IYNDEDPE 415 H A +++ + +PN+ +I S +D +++W + EN N PE Sbjct: 115 --------------HNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPE 157 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 91/253 (35%), Gaps = 50/253 (19%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 S L SA DHTI W+ + V + + L + Sbjct: 2 SVILASAGYDHTIRFWEALTGV-------CSRTIQHADSQVNRLEITSDKKYLAAAG--H 52 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 + ++D RSNN P S + H V ++F + +++++ S D T+ +WD+R+ Sbjct: 53 LHVRLYDIRSNN-PNPVSSFEGHKGNVTSIAFQQENRWMVSS-SEDGTIKVWDVRSPS-- 108 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL--SKIGEEQSPEDA-------- 359 + H + +V P+ ++ S D + +WDL ++ + +PED Sbjct: 109 VQRNYKHNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSV 167 Query: 360 -------------------------EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + E + HT I+ + + + + S Sbjct: 168 ASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCS 226 Query: 395 EDNIMQVWQMAEN 407 D+ +VW + +N Sbjct: 227 ADHTARVWNIEDN 239 >6Q8F-A nrPDB Length = 514 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 90/235 (38%), Gaps = 16/235 (6%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVP-KEGKVVDAKTIFTGHTAVVEDV 233 G + ++P+ +L++ S D I +W+ + ++ A+ F V + Sbjct: 213 GQKSHVECARFSPD-GQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 271 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 + + + A D K+ +W +S + AH+ V CLSF+ S IL + S Sbjct: 272 CFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRFER--AHSKGVTCLSFSKDSSQIL-SAS 327 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 D+T+ + L++ K L F H + + ++ I+ S+ +D + +W++ Sbjct: 328 FDQTIRIHGLKSGKT-LKEFRGHSSFVNEATFTQDGHYII-SASSDGTVKIWNMKT---- 381 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 + L G ++ P P + N + + M I Sbjct: 382 ----TECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQI 432 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 103/280 (36%), Gaps = 46/280 (16%) Query: 132 YMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL-RGHQKEGYGLSWNPNLS 190 ++ ++AT + V+ SG+C R R H K LS++ S Sbjct: 272 CFSRDTEMLATGAQDGKIKVWKIQ--------SGQCL--RRFERAHSKGVTCLSFS-KDS 320 Query: 191 GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQ 250 +LSAS D TI + + K F GH++ V + ++ + S + D Sbjct: 321 SQILSASFDQTIRIHGL-------KSGKTLKEFRGHSSFVNEATFTQDGHYII-SASSDG 372 Query: 251 KLMIWDTRSNNTSKPSHSV---DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 + IW+ ++ S S+ VN + P + + TV + +++ Sbjct: 373 TVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQ- 431 Query: 308 LKLHSFESHK----DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP 363 + SF S K D + SP E I +GE+ Sbjct: 432 -IVRSFSSGKREGGDFVCC-ALSPRGEWIYC---------------VGEDFVLYCFSTVT 474 Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 +L H + + +P++ +I + SED ++++W+ Sbjct: 475 GKLERTLTVHEKDVIGIAHHPHQ-NLIATYSEDGLLKLWK 513 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 66/181 (36%), Gaps = 15/181 (8%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H VN A + Q+ I + + V ++ + + S G Sbjct: 348 GHSSFVNEATFT-QDGHYIISASSDGTVKIW----NMKTTECSNTFKSLGSTAGTDITVN 402 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + P H + + +T+ + ++ +G++V + + + E Sbjct: 403 SVILLPKNPEHFVVCNRSNTVVIMNM-----QGQIVRSFSSGKREGGDFVCCALSPRGEW 457 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 ++ V +D L + S T K ++ H +V ++ +P+ ++AT S D + LW Sbjct: 458 IY-CVGEDFVLYCF---STVTGKLERTLTVHEKDVIGIAHHPHQ-NLIATYSEDGLLKLW 512 Query: 302 D 302 Sbjct: 513 K 513 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 16/137 (11%), Positives = 47/137 (34%), Gaps = 15/137 (10%) Query: 278 CLSFNPYSEFILATGSAD---KTVALWDLRNLKLKL----HSFESHKDEIFQVQWSPHNE 330 L + + + + D A+ D+ K H K + ++SP + Sbjct: 169 ALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQ 228 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 390 L + D + VW+ + + + ++ + ++ + ++ Sbjct: 229 -YLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMM------DDAVLCMCFSRD-TEML 280 Query: 391 CSVSEDNIMQVWQMAEN 407 + ++D ++VW++ Sbjct: 281 ATGAQDGKIKVWKIQSG 297 >3BG0-A nrPDB Length = 316 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 95/274 (34%), Gaps = 37/274 (13%) Query: 113 GKIEIEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 171 G+I I HEG V + + P I+A+ + V+++ + +G Sbjct: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR--------EENGTWEKSH 97 Query: 172 RLRGHQKEGYGLSWNPNLSG-HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 GH + W P+ G L S D I L + + + K I HT Sbjct: 98 EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ----WEVKKINNAHTIGC 153 Query: 231 EDVSWH----------------LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 VSW + F S D + +W + K ++AH+ Sbjct: 154 NAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSD 213 Query: 275 EVNCLSFNPYSEF---ILATGSADKTVALW---DLRNLKLKLHSFESHKDEIFQVQWSPH 328 V +++ P +A+ S D V +W D + D ++ V WS Sbjct: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWS-I 272 Query: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362 ILA SG D ++ +W S G+ D G Sbjct: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 95/250 (38%), Gaps = 40/250 (16%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVA 247 L + S D ++ ++D+ + GH V V+W H ++ ++ S + Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQ-----ILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY-SEFILATGSADKTVAL--WDLR 304 D+K++IW N T + SH H + VN + + P+ ILA GS+D ++L + Sbjct: 79 YDRKVIIW-REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGE 137 Query: 305 NLKLKLHSFESHKDEIFQVQWS----------------PHNETILASSGTDRRLNVWDLS 348 +H V W+ P+ AS G D + +W Sbjct: 138 GQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW--- 194 Query: 349 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE---PWVICSVSEDNIMQVWQMA 405 ++ EDG + H+ + D +W P+ I S S+D + +W Sbjct: 195 --------KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 Query: 406 ENIYNDEDPE 415 + N P+ Sbjct: 247 DASSNTWSPK 256 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 39/144 (27%), Positives = 66/144 (45%), Gaps = 21/144 (14%) Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN-LKLKLHSFESHKDE 319 NT SH H A+++ Y LAT S+D++V ++D+RN ++ + H+ Sbjct: 6 NTVDTSHEDMIHDAQMD------YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 Query: 320 IFQVQW-SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 378 ++QV W P ILAS DR++ +W E+G E H GH + ++ Sbjct: 60 VWQVAWAHPMYGNILASCSYDRKVIIWR------------EENGTWEKSHEHAGHDSSVN 107 Query: 379 DFSWNPNEPWVI-CSVSEDNIMQV 401 W P++ +I S D + + Sbjct: 108 SVCWAPHDYGLILACGSSDGAISL 131 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 41/109 (37%), Gaps = 14/109 (12%) Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 SH+D I Q + T LA+ +DR + ++D+ G+ L+ GH Sbjct: 10 TSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQI------------LIADLRGH 56 Query: 374 TAKISDFSW-NPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPE 421 + +W +P ++ S S D + +W+ + D Sbjct: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSS 105 >5K1B-B nrPDB Length = 677 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 46/235 (19%), Positives = 86/235 (36%), Gaps = 34/235 (14%) Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 239 L +P L L +A D I +W ++ ++ + HT V D+ + Sbjct: 33 VNALQLDPAL-NRLFTAGRDSIIRIWSVNQHKQDPYI----ASMEHHTDWVNDIVLC-CN 86 Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 S + D + +W+ + H V L++ E ++A+ D+ + Sbjct: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRT---HKDYVKALAYAKDKE-LVASAGLDRQIF 142 Query: 300 LWDL--------RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 351 LWD+ N + S +KD I+ + + TI+ S T++ L VWD Sbjct: 143 LWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-TIIVSGSTEKVLRVWDPRTCA 201 Query: 352 EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + L GHT + N + + S S D +++W + + Sbjct: 202 K--------------LMKLKGHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQ 241 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 56/313 (17%), Positives = 108/313 (34%), Gaps = 45/313 (14%) Query: 138 CIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSAS 197 + T S + ++ +H P + H + N L+SAS Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPY-------IASMEHHTDWVNDIVLCCNGKT-LISAS 94 Query: 198 DDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDT 257 D T+ +W+ + H V+ +++ + L S D+++ +WD Sbjct: 95 SDTTVKVWN-------AHKGFCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQIFLWDV 146 Query: 258 RS------NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 + +N + + S+ + + L+ N I+ +GS +K + +WD R KL Sbjct: 147 NTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG-TIIVSGSTEKVLRVWDPRT-CAKLM 204 Query: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELL---- 367 + H D + + + L S +D + +W L + + ++G L Sbjct: 205 KLKGHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263 Query: 368 ---FIHGGHTAKISDFSW-NPNEPWVICSV-----------SEDNIMQVW-QMAENIYND 411 GG KI NP+ +IC S D +W ++ N Sbjct: 264 FTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNK 323 Query: 412 EDPEGSVDPEGQG 424 +G + G Sbjct: 324 WTLKGIHNFRASG 336 Score = 95.3 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 34/180 (18%), Positives = 76/180 (42%), Gaps = 10/180 (5%) Query: 227 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286 V + LF + D + IW + S++ HT VN + + Sbjct: 30 RNGVNALQLDPALNRLF-TAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 ++ + S+D TV +W+ + + + +HKD + + ++ ++ ++AS+G DR++ +WD Sbjct: 89 TLI-SASSDTTVKVWN-AHKGFCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQIFLWD 145 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 ++ + + + G+ I + N +I S S + +++VW Sbjct: 146 VNTLTALTASNNTVTTS-----SLSGNKDSIYSLAMN-QLGTIIVSGSTEKVLRVWDPRT 199 Score = 87.9 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 52/306 (16%), Positives = 107/306 (34%), Gaps = 28/306 (9%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H+ V Y ++ ++A+ + ++D + S L G++ Y Sbjct: 116 HKDYVKALAYA-KDKELVASAGLDRQIFLWDVNTLTALTA-SNNTVTTSSLSGNKDSIYS 173 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 L+ N L ++S S + + +WD K K GHT V+ + + Sbjct: 174 LAMN-QLGTIIVSGSTEKVLRVWDPRTCAKLMK-------LKGHTDNVKALLLNRDGTQC 225 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 S + D + +W S + + H V L N + + +G D+ + D Sbjct: 226 L-SGSSDGTIRLW---SLGQQRCIATYRVHDEGVWALQVN-DAFTHVYSGGRDRKIYCTD 280 Query: 303 LRNLKLKLHSFESHKDEI--FQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 LRN +++ E K + ++ S + + T +N W L I ++ D + Sbjct: 281 LRNPDIRVLICEE-KAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYD 339 Query: 361 DGPPELLFIHGGH-------TAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDED 413 + + A I ++ ++ + +N+ W + + + Sbjct: 340 NDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAY-WDVLKAC--KVE 396 Query: 414 PEGSVD 419 G VD Sbjct: 397 DLGKVD 402 >6EMK-B nrPDB Length = 303 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 93/250 (37%), Gaps = 33/250 (13%) Query: 163 PSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTI 222 + NP GH+ +S+ + + ++++S+D TI +WD+ + Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNYK----- 114 Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 H A V +V H L S D + IWD N + D + LS Sbjct: 115 ---HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPED--DTSLQSLSMA 168 Query: 283 PYSEFILATGSADKTVALWDLRNLK-----LKLHSFESHKDEIFQVQWSPHNETILASSG 337 LA + +W++ N + F +H I ++ S + LA+ Sbjct: 169 SDGSM-LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHLATCS 226 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 D VW + + ++ D GH + D +++ + +++ + S D+ Sbjct: 227 ADHTARVWSIDDDFKLETTLD-------------GHQRWVWDCAFSADSAYLV-TASSDH 272 Query: 398 IMQVWQMAEN 407 +++W ++ Sbjct: 273 YVRLWDLSTR 282 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 37/178 (20%), Positives = 71/178 (39%), Gaps = 24/178 (13%) Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299 + S D + W+ + S+ D+ +VN L + + G + V Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDS---QVNRLEITNDKKLLATAGHQN--VR 56 Query: 300 LWDLRN-LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 L+D+R + SFE H+ + V + N ++ SS D + VWD+ ++ + Sbjct: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS-EDGTIKVWDVRSPSIPRNYK- 114 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN-IYNDEDPE 415 H A +++ +PN+ +I S D +++W + EN + PE Sbjct: 115 --------------HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPE 157 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 92/253 (36%), Gaps = 50/253 (19%) Query: 190 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249 S L+SA DHTI W+ + V + + L + Sbjct: 2 SVILVSAGYDHTIRFWEALTGV-------CSRTIQHSDSQVNRLEI-TNDKKLLATAGH- 52 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 Q + ++D R+ N P S + H V +SF + +++ T S D T+ +WD+R+ + Sbjct: 53 QNVRLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIP 110 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL--SKIGEEQSPED--------- 358 + H + +V P+ ++ S D + +WDL ++ + +PED Sbjct: 111 RN--YKHNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 Query: 359 ------------------------AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + + + H+ I+ + + + + S Sbjct: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCS 226 Query: 395 EDNIMQVWQMAEN 407 D+ +VW + ++ Sbjct: 227 ADHTARVWSIDDD 239 >4G56-B nrPDB Length = 357 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 90/238 (37%), Gaps = 21/238 (8%) Query: 119 IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 K H+ V + + V V+D + + H Sbjct: 134 AKYEHDDIVKTLSVFS-DGTQAVSGGKDFSVKVWDLS----------QKAVLKSYNAHSS 182 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 E ++ P LS +D I LWD + PK +D F + V+WH Sbjct: 183 EVNCVAACPGKDTIFLSCGEDGRILLWD-TRKPKPATRID----FCASDTIPTSVTWHPE 237 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 + F + + + + ++ ++++ S H+ + L+++ +S LA+ S D TV Sbjct: 238 KDDTFACGDETGNVSLVNIKNPDSAQTSA---VHSQNITGLAYSYHSSPFLASISEDCTV 294 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 A+ D ++ SH+D + V WSP + + + G D ++ L G ++ Sbjct: 295 AVLDA--DFSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENL 350 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 101/283 (35%), Gaps = 33/283 (11%) Query: 117 IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGH 176 + E V ++ + ++A+ + V +++ + S H Sbjct: 87 CTAGVQTEAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYE------H 138 Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 LS + +S D ++ +WD+S + H++ V V+ Sbjct: 139 DDIVKTLSVFSD-GTQAVSGGKDFSVKVWDLSQKAV-------LKSYNAHSSEVNCVAAC 190 Query: 237 LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK 296 +++F S +D ++++WDTR + + T ++++P + A G Sbjct: 191 PGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIP-TSVTWHPEKDDTFACGDETG 249 Query: 297 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 V+L +++N + H I + +S H+ LAS D + V D Sbjct: 250 NVSLVNIKNPDSA-QTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDAD-------- 300 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 399 +F H ++ +W+P + +V D+ + Sbjct: 301 -------FSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 93/245 (37%), Gaps = 26/245 (10%) Query: 162 DPSGECNPDLRLRG--HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 DP G N L G + ++W +L ASD + LW+I + KE +V+ Sbjct: 77 DPEGAPNESLCTAGVQTEAGVTDVAWVSEKG--ILVASDSGAVELWEI--LEKESLLVNK 132 Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279 + H +V+ +S S D + +WD K S +AH++EVNC+ Sbjct: 133 FAKYE-HDDIVKTLSVFSDGTQAV-SGGKDFSVKVWDLSQKAVLK---SYNAHSSEVNCV 187 Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEI-FQVQWSPHNETILASSGT 338 + P + I + D + LWD R K D I V W P + A Sbjct: 188 AACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDE 247 Query: 339 DRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNI 398 +++ ++ Q+ H+ I+ +++ + + S+SED Sbjct: 248 TGNVSLVNIKNPDSAQT--------------SAVHSQNITGLAYSYHSSPFLASISEDCT 293 Query: 399 MQVWQ 403 + V Sbjct: 294 VAVLD 298 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 55/137 (40%), Gaps = 20/137 (14%) Query: 273 TAEVNCLSFNPYSEFILATGSADKTVALWDL-RNLKLKLHSF--ESHKDEIFQVQWSPHN 329 A V +++ ++A+ S V LW++ L ++ F H D + + + Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSVF-SD 150 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 T S G D + VWDLS+ +L + H+++++ + P + + Sbjct: 151 GTQAVSGGKDFSVKVWDLSQ--------------KAVLKSYNAHSSEVNCVAACPGKDTI 196 Query: 390 ICSVSEDNIMQVWQMAE 406 S ED + +W + Sbjct: 197 FLSCGEDGRILLWDTRK 213 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 31/99 (31%), Gaps = 11/99 (11%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H + Y + +A+ + V V D D S H+ G Sbjct: 268 HSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS-----------HRDFVTG 316 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221 ++W+P + DH + + + + ++ K Sbjct: 317 VAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIATKA 355 >4J0W-A nrPDB Length = 343 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 97/293 (33%), Gaps = 23/293 (7%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPD-PSGECNPDLRLR 174 +I + H+ + P + I + ++ + P + + + Sbjct: 6 DIRVLRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP 64 Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH ++ + + +L S I +W E + FTGH V ++ Sbjct: 65 GHSSHVLCMAISSD-GKYLASGDRSKLILIW-------EAQSCQHLYTFTGHRDAVSGLA 116 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + S + D+ + +W+ N+ ++ H V L E + G Sbjct: 117 FR-RGTHQLYSTSHDRSVKVWNVAENSY---VETLFGHQDAVAALD-ALSRECCVTAGGR 171 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 D TV +W + + F H+ I + NE + S D + +W LSK Sbjct: 172 DGTVRVWKIPEESQLV--FYGHQGSIDCI--HLINEEHMVSGADDGSVALWGLSKKRPLA 227 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 +A E + ++ ++ + S + +++WQ E Sbjct: 228 LQREAHGLRGEPGLEQPFWISSVAALL----NTDLVATGSHSSCVRLWQCGEG 276 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 94/247 (38%), Gaps = 29/247 (11%) Query: 166 ECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK----EGKVVDAKT 221 E LRGHQ L P+ S SA+ D +I W + + K A+ Sbjct: 3 EAADIRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEG 61 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 GH++ V ++ S + ++IW+ +S ++ H V+ L+F Sbjct: 62 KPPGHSSHVLCMAIS-SDGKYLASGDRSKLILIWEAQSCQH---LYTFTGHRDAVSGLAF 117 Query: 282 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 341 + + +T S D++V +W++ + + H+D + + + E + + G D Sbjct: 118 RRGTHQLYST-SHDRSVKVWNVAENSY-VETLFGHQDAVAALD-ALSRECCVTAGGRDGT 174 Query: 342 LNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 + VW + P E + GH I + + S ++D + + Sbjct: 175 VRVWKI---------------PEESQLVFYGHQGSID--CIHLINEEHMVSGADDGSVAL 217 Query: 402 WQMAENI 408 W +++ Sbjct: 218 WGLSKKR 224 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 52/163 (31%), Gaps = 27/163 (16%) Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE----- 314 + + H + CL P I + + D ++ W + + + Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGA 59 Query: 315 -----SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 H + + S + LAS + + +W+ L+ Sbjct: 60 EGKPPGHSSHVLCMAIS-SDGKYLASGDRSKLILIWEAQSCQH--------------LYT 104 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 GH +S ++ + S S D ++VW +AEN Y + Sbjct: 105 FTGHRDAVSGLAFRR-GTHQLYSTSHDRSVKVWNVAENSYVET 146 >1NR0-A nrPDB Length = 611 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 95/255 (37%), Gaps = 18/255 (7%) Query: 163 PSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTI 222 P G H + +P+ + S + +WD + K Sbjct: 45 PVGSLTDTEIYTEHSHQTTVAKTSPS-GYYCASGDVHGNVRIWDTTQTTHILKTTIPVF- 102 Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 + V+D+SW + + + + +T + ++ +N + F Sbjct: 103 ----SGPVKDISWDSESKRIAAVG--EGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFK 156 Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 P F + +GS D TVA+++ K K +F H + V+++P ++ AS+G D + Sbjct: 157 PSRPFRIISGSDDNTVAIFEGPPFKFK-STFGEHTKFVHSVRYNPDG-SLFASTGGDGTI 214 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 +++ + ED + H+ + +W+P+ I S S D +++W Sbjct: 215 VLYNGVDGTKTGVFEDD-------SLKNVAHSGSVFGLTWSPDGTK-IASASADKTIKIW 266 Query: 403 QMAENIYNDEDPEGS 417 +A P G+ Sbjct: 267 NVATLKVEKTIPVGT 281 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 124/338 (36%), Gaps = 63/338 (18%) Query: 100 SEKGEFGGFGSVSGKIEI--EIKINH---------EGEVNRARYMPQNPCIIATKTPS-- 146 S G + G V G + I + H G V + ++ I A Sbjct: 68 SPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRER 127 Query: 147 -SDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW 205 V +FD + L G + + + P+ ++S SDD+T+ ++ Sbjct: 128 FGHVFLFDT------------GTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF 175 Query: 206 DISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD----TRSNN 261 EG K+ F HT V V ++ LF S D +++++ T++ Sbjct: 176 -------EGPPFKFKSTFGEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGVDGTKTGV 227 Query: 262 TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321 S AH+ V L+++P I A+ SADKT+ +W++ LK++ Sbjct: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKI-ASASADKTIKIWNVATLKVEKTI--------- 277 Query: 322 QVQWSPHNETILASSGTDRRL-NVWDLSKIGEEQSPEDAEDGPPE---LLFIHGGHTAKI 377 P I D++L +W + + PE + + GH I Sbjct: 278 -----PVGTRI-----EDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAI 327 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 + S + + + + +E + + W ++ I N P+ Sbjct: 328 TALSSSADGKTLFSADAEGH-INSWDISTGISNRVFPD 364 Score = 88.7 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 90/269 (33%), Gaps = 19/269 (7%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 +N + P P I + + + V +F+ K H K + + + Sbjct: 149 AMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKST----------FGEHTKFVHSVRY 198 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 NP+ S S D TI L++ K G D H+ V ++W + S Sbjct: 199 NPDGS-LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI-AS 256 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 + D+ + IW+ + K + + + ++ L + SA+ + + Sbjct: 257 ASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW---TKQALVSISANGFINFVN-PE 312 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 L H I + S +T+ S+ + +N WD+S + D Sbjct: 313 LGSIDQVRYGHNKAITALSSSADGKTLF-SADAEGHINSWDISTGISNRVFPDVH--ATM 369 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + I + SW+ + V S Sbjct: 370 ITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 33/169 (19%), Positives = 66/169 (39%), Gaps = 21/169 (12%) Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 + D K+ ++ S + ++ H AE+ ++F+ F++AT + V Sbjct: 459 DKQFVAVGGQDSKVHVYKL-SGASVSEVKTI-VHPAEITSVAFSNNGAFLVAT-DQSRKV 515 Query: 299 ALWDLRNLKLKLHSF--ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 + + N H+ H ++ V WSP N LA+ D + VW+++K Sbjct: 516 IPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPS----- 569 Query: 357 EDAEDGPPELLFIHGGH-TAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 + I G H + ++ W I S +D+ ++ W + Sbjct: 570 -------DHPIIIKGAHAMSSVNSVIWLNETT--IVSAGQDSNIKFWNV 609 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 60/172 (34%), Gaps = 17/172 (9%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 + + +A S V V+ SG +++ H E ++++ N + Sbjct: 456 LSNDKQFVAVGGQDSKVHVYKL---------SGASVSEVKTIVHPAEITSVAFSNNGAFL 506 Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252 + + D + + S F HTA V VSW + L + + D + Sbjct: 507 VAT---DQSRKVIPYSVANNFELAHTNSWTF--HTAKVACVSWSPDNVRL-ATGSLDNSV 560 Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 ++W+ + + VN + + +E + + D + W++ Sbjct: 561 IVWNMNKPSDHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDSNIKFWNVP 610 >3ODT-A nrPDB Length = 313 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 88/247 (35%), Gaps = 39/247 (15%) Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228 P L GHQ LS+ G ++S S D T +W K H A Sbjct: 96 PLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVW---------KEGSLVYNLQAHNA 143 Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-HTAEVNCLSFNPYSEF 287 V D E+ F + + D+ + +W K + H V L+ F Sbjct: 144 SVWDAKVVSFSENKFLTASADKTIKLW-----QNDKVIKTFSGIHNDVVRHLAVVDDGHF 198 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 I + S D + L D+ + L ++E H+ ++ ++ P+ + + S G DR + +W Sbjct: 199 I--SCSNDGLIKLVDMHTGDV-LRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSK 253 Query: 348 SKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 +Q + + G I S DN+++++ ++ Sbjct: 254 ENGSLKQVITLPAISIWSVDCMSNGD----------------IIVGSSDNLVRIFSQEKS 297 Query: 408 IYNDEDP 414 + ED Sbjct: 298 RWASEDE 304 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 43/268 (16%), Positives = 91/268 (33%), Gaps = 44/268 (16%) Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221 DP L+GH ++ + + S S D T+ LW Sbjct: 3 DPFTGYQLSATLKGHDQDVRDVVA--VDDSKVASVSRDGTVRLWSKD------DQWLGTV 54 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 ++TG + V + + L D + + + P +++ H V LSF Sbjct: 55 VYTG-QGFLNSVCY-DSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF 112 Query: 282 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 341 + ++ +GS DKT +W +++ ++H ++ + +E ++ D+ Sbjct: 113 ---QDGVVISGSWDKTAKVWK---EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKT 166 Query: 342 LNVWDLSKI--------------------------GEEQSPEDAEDGPPELLFIHGGHTA 375 + +W K+ + + + ++L + GH + Sbjct: 167 IKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHES 226 Query: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + PN I S ED +++W Sbjct: 227 FVYCIKLLPNGD--IVSCGEDRTVRIWS 252 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 64/187 (34%), Gaps = 29/187 (15%) Query: 117 IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG- 175 + H V A+ + + T + + ++ K G Sbjct: 135 VYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKT------------FSGI 182 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H L+ GH +S S+D I L D+ D + GH + V + Sbjct: 183 HNDVVRHLAVV--DDGHFISCSNDGLIKLVDM-------HTGDVLRTYEGHESFVYCIKL 233 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + S +D+ + IW ++ N + K ++ A ++ S + S + GS+D Sbjct: 234 LPNGD--IVSCGEDRTVRIW-SKENGSLKQVITLPA----ISIWSVDCMSNGDIIVGSSD 286 Query: 296 KTVALWD 302 V ++ Sbjct: 287 NLVRIFS 293 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 59/156 (37%), Gaps = 18/156 (11%) Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ 322 + S ++ H +V + S+ +A+ S D TV LW + L + + + Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSK--VASVSRDGTVRLWSKDDQWLGTVVYTG-QGFLNS 64 Query: 323 VQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 V + + +L G D +N P A G L+ GH + S+ Sbjct: 65 VCYD-SEKELLLFGGKDTMIN----------GVPLFATSGEDP-LYTLIGHQGNVCSLSF 112 Query: 383 NPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 + V+ S S D +VW+ +YN + SV Sbjct: 113 ---QDGVVISGSWDKTAKVWKEGSLVYNLQAHNASV 145 >5WYK-BB nrPDB Length = 943 Score = 111 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 97/278 (34%), Gaps = 41/278 (14%) Query: 139 IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASD 198 ++ T + ++ +FD H + L + L++ S Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIED---------AHDAAIWSLDLTSD-GKRLVTGSA 493 Query: 199 DHTICLWD--ISAVPKEGKVVDAKTIFTGH-------TAVVEDVSWHLLHESLFGSVADD 249 D T+ WD + G + H T + V L S+ D Sbjct: 494 DKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LD 552 Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 309 + ++ ++ K S+ H V + + S+ I+ T SADK + +W L Sbjct: 553 NTVKVF---FLDSMKFYLSLYGHKLPVLSIDISFDSKMII-TSSADKNIKIWGLDFGDCH 608 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 F +H+D I V++ P + S D + WD K E + Sbjct: 609 KSLF-AHQDSIMNVKFLPQSHNFF-SCSKDAVVKYWDGEKF--------------ECIQK 652 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 H +++ + + +V+ S S D+ +++W+ E+ Sbjct: 653 LYAHQSEVWALAVATDGGFVV-SSSHDHSIRIWEETED 689 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 88/236 (37%), Gaps = 24/236 (10%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT-KHPSKPDPSGECNPDLRLRGH---- 176 H+ + + + + T + V +D+ ++ P + P L+L H Sbjct: 471 AHDAAIWSLD-LTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKL-HHDTTL 528 Query: 177 --QKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 + + +P+ +L + D+T+ ++ + + + GH V + Sbjct: 529 ELTDDILCVRVSPD-DRYLAISLLDNTVKVFFLDS-------MKFYLSLYGHKLPVLSID 580 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + + S + D+ + IW + K S+ AH + + F P S + S Sbjct: 581 ISFDSKMIITS-SADKNIKIWGLDFGDCHK---SLFAHQDSIMNVKFLPQSHNFF-SCSK 635 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 D V WD + + +H+ E++ + + + SS D + +W+ ++ Sbjct: 636 DAVVKYWDGEKFEC-IQKLYAHQSEVWALAVATDGG-FVVSSSHDHSIRIWEETED 689 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 83/224 (37%), Gaps = 31/224 (13%) Query: 186 NPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL----HE 240 N + G L+ SA +D + +WDI K+ D + L Sbjct: 34 NGSGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDT 91 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 L D + +WD S + + H A + L F+ L +GS D + + Sbjct: 92 DLLAVGYADGVIKVWDLMS---KTVLLNFNGHKAAITLLQFDGTG-TRLISGSKDSNIIV 147 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WDL ++ L+ SHKD I W E L S+ D + +WDL Sbjct: 148 WDLV-GEVGLYKLRSHKDSITGF-WCQ-GEDWLISTSKDGMIKLWDLKTH---------- 194 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 + + H HT + + + ++ + D+ +++W++ Sbjct: 195 ----QCIETHIAHTGECWGLAV---KDDLLITTGTDSQVKIWKL 231 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 35/176 (19%), Positives = 61/176 (34%), Gaps = 28/176 (15%) Query: 135 QNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLL 194 ++ ++A + V+D L GH+ L ++ L+ Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSK----------TVLLNFNGHKAAITLLQFDGT-GTRLI 137 Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI 254 S S D I +WD+ K H + + E S + D + + Sbjct: 138 SGSKDSNIIVWDLVGEVGLYK-------LRSHKDSITG--FWCQGEDWLISTSKDGMIKL 188 Query: 255 WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKL 308 WD + T + + AHT E L+ + +L T D V +W D+ N K+ Sbjct: 189 WDLK---THQCIETHIAHTGECWGLA---VKDDLLITTGTDSQVKIWKLDIENDKM 238 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 43/177 (24%), Positives = 71/177 (40%), Gaps = 30/177 (16%) Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSH---------SVDAHTAEVNCLSFNPYSEFIL 289 L S +D + IWD ++ + + A AE L + ++ +L Sbjct: 38 PGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTD-LL 94 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 A G AD + +WDL + K L +F HK I +Q+ ++ S D + VWDL Sbjct: 95 AVGYADGVIKVWDLMS-KTVLLNFNGHKAAITLLQFDGTGTRLI-SGSKDSNIIVWDL-- 150 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 L+ H I+ F W E W+I S S+D ++++W + Sbjct: 151 ------------VGEVGLYKLRSHKDSITGF-WCQGEDWLI-STSKDGMIKLWDLKT 193 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 42/232 (18%), Positives = 81/232 (34%), Gaps = 22/232 (9%) Query: 180 GYGLSWNPNLSGHL---LSASDDHTICLWDISAVPKEGKVVDAKTI----FTGHTAVVED 232 SW S L L+ S +TI + I ++ G V Sbjct: 338 IKSASWTTVSSSKLELVLTTSS-NTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRS 396 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + ++ + A + L IW+ + T K + + F P ++ G Sbjct: 397 IDIS--DDNKLLATASNGSLKIWNIK---THKCIRTFEC--GYALTCKFLP-GGLLVILG 448 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 + + + L+DL + L ++H I+ + + + L + D+ + WD K+ Sbjct: 449 TRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKR-LVTGSADKTVKFWDF-KVEN 506 Query: 353 EQSPEDAEDGPPELLFIHGG---HTAKISDFSWNPNEPWVICSVSEDNIMQV 401 P P L H T I +P++ ++ S+ DN ++V Sbjct: 507 SLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDNTVKV 557 Score = 35.6 bits (80), Expect = 0.048, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 29/79 (36%), Gaps = 5/79 (6%) Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 ++ S+ D +N+WD+ D PP G A+ + + + + Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDG--LPPGASDARGAKPAECTYLEAHKD-TDL 93 Query: 390 ICSVSEDNIMQVWQMAENI 408 + D +++VW + Sbjct: 94 LAVGYADGVIKVWDLMSKT 112 >5OQL-L nrPDB Length = 557 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 87/222 (39%), Gaps = 24/222 (10%) Query: 145 PSSDVLVFDYTKHPSKPDPSGECNPDLRLRG---HQKEGYGLSWNPNLSGHLLSASDDHT 201 P VLV + G+ + L+ H++ + W+P L+S SDD T Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL--LHESLFGSVADDQKLMIWDTRS 259 + LWD+ + D +FTGHT V ++ + +L S + D+ + +WD R+ Sbjct: 169 VRLWDLPSN-------DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARA 221 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 + + H + + P +LA +++ DL K L +H+ Sbjct: 222 PGGAVMTFK---HADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAK-PLRLITNHQKT 275 Query: 320 IFQVQWSPHNETILASSGTDRRLNV-----WDLSKIGEEQSP 356 + + + ++ S D + V W++ + SP Sbjct: 276 VTSLSLASQGRRVV-SGSLDGHVKVFETTSWNVVAGAKYPSP 316 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 37/235 (15%), Positives = 75/235 (31%), Gaps = 27/235 (11%) Query: 99 DSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHP 158 D+ + + G + + ++ H+ V ++ P + + + V ++D + Sbjct: 119 DTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND 178 Query: 159 SKPDPSGECNPDLRLRGHQKEGYGLSWNPNL--SGHLLSASDDHTICLWDISAVPKEGKV 216 P GH ++ P S L+S S D T+ +WD A Sbjct: 179 ----------PTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMT 228 Query: 217 VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEV 276 H +EDV +L + + + D +KP + H V Sbjct: 229 FK-------HADPIEDVLPLPSGTTLLAASG--NAISVLDL---VAAKPLRLITNHQKTV 276 Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNET 331 LS + +GS D V +++ + + + I + + Sbjct: 277 TSLSLASQGR-RVVSGSLDGHVKVFE--TTSWNVVAGAKYPSPILSLSVITAGAS 328 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 69/185 (37%), Gaps = 22/185 (11%) Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284 G TA+V + +V ++ I+ R +P ++ +E +C P Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIR---KREPLKTIGRFDSEAHCGEIRPD 110 Query: 285 SEFILATGSADKTVALWDLRNLKLKL--HSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 +L G + ++D+ + ++ HK ++ +WSP T L S D+ + Sbjct: 111 GR-VLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTV 169 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPN--EPWVICSVSEDNIMQ 400 +WDL + + GHT + ++ P ++ S S D ++ Sbjct: 170 RLWDLPSNDPTR--------------LFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVR 215 Query: 401 VWQMA 405 VW Sbjct: 216 VWDAR 220 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 51/144 (35%), Gaps = 27/144 (18%) Query: 271 AHTAEVNC--LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF-----ESHKDEIFQV 323 TA V+ ++ ++ T V ++ +R + L + E+H EI Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAG--PRVEIFSIRK-REPLKTIGRFDSEAHCGEIR-- 108 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 P ++A G D G Q + + +L H + W+ Sbjct: 109 ---PDGRVLVA--GED----------TGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWS 153 Query: 384 PNEPWVICSVSEDNIMQVWQMAEN 407 P E + S S+D +++W + N Sbjct: 154 PTELTTLMSCSDDKTVRLWDLPSN 177 >4BH6-A nrPDB Length = 308 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 103/255 (40%), Gaps = 47/255 (18%) Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 LSW HL + + ++D+ +GH V +SW+ Sbjct: 66 TSLSWIG-AGSHLAVGQANGLVEIYDVMK-------RKCIRTLSGHIDRVACLSWNNH-- 115 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + S + D +++ D R + ++++HT EV L +N ++ LA+G D V + Sbjct: 116 -VLTSGSRDHRILHRDVRMPD--PFFETIESHTQEVCGLKWN-VADNKLASGGNDNVVHV 171 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG--TDRRLNVWDLSKIGEEQSPED 358 ++ K + +F+ HK + + WSPH +LA+ G DRRL +W+++ + + Sbjct: 172 YE-GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDS 230 Query: 359 AED--------GPPELLFIHG---------------------GHTAKISDFSWNPNEPWV 389 EL+ HG GH+ ++ + + + V Sbjct: 231 GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTV 290 Query: 390 ICSVSEDNIMQVWQM 404 + S + D ++ W++ Sbjct: 291 V-SGAGDETLRYWKL 304 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 81/247 (32%), Gaps = 62/247 (25%) Query: 103 GEFGGFGSVSGKIEIEIKINHE------GEVNRARYMPQNPCIIATKTPSSDVLVFDYTK 156 G G +G +EI + + G ++R + N ++ + + +L D Sbjct: 74 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDV-- 131 Query: 157 HPSKPDPSGEC-------------------------------------NPDLRLRGHQKE 179 PDP E +P L H+ Sbjct: 132 --RMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAA 189 Query: 180 GYGLSWNPNLSGHLLSASD--DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 ++W+P+ G L + D + +W+++ K + + ++ W Sbjct: 190 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ--------ICNMVWSK 241 Query: 238 LHESLFGSVADDQ-KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK 296 L S + L +WD N+ P + H+ V L+ + ++ +G+ D+ Sbjct: 242 NTNELVTSHGYSKYNLTLWD---CNSMDPIAILKGHSFRVLHLTLSNDGTTVV-SGAGDE 297 Query: 297 TVALWDL 303 T+ W L Sbjct: 298 TLRYWKL 304 >6ELZ-p nrPDB Length = 460 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 94/331 (28%), Gaps = 77/331 (23%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDD 199 I + + V +D + N + GH + + + L+SA +D Sbjct: 118 IISGSYDGIVRTWDLS-----------GNVQKQYSGHSGPIRAVKY--ISNTRLVSAGND 164 Query: 200 HTICLWDISAV----------------PKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF 243 T+ LW + I GH A V + S Sbjct: 165 RTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS--DNSRI 222 Query: 244 GSVADDQKLMIWDT--RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 S + D + W T + P ++ +++ + + D T+ Sbjct: 223 LSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM-----KDGTIR-- 275 Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL-------------- 347 + L ESH + QV + + T+ S D + WDL Sbjct: 276 ----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYS 331 Query: 348 ---------------SKIGEEQSPEDAEDGPPELLFIHG--GHTAKISDFSWNPNEPWVI 390 + D G + GH +S P +++ Sbjct: 332 LLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYIL 391 Query: 391 CSVSEDNIMQVWQMAEN--IYNDEDPEGSVD 419 CS S D ++VW + +Y + SV Sbjct: 392 CSGSHDGTVKVWDVRSTSPMYTITREDKSVQ 422 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 57/328 (17%), Positives = 103/328 (31%), Gaps = 66/328 (20%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSG-------------ECN 168 H G + +Y+ + + + ++ K + Sbjct: 142 GHSGPIRAVKYISNTR--LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGK 199 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD---------------------- 206 L GH+ + + + +LSAS D++I W Sbjct: 200 TLAILEGHKAPVVSIDVS--DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKI 257 Query: 207 ---------ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDT 257 ++ + ++ HTA VE V + ++ SV+ D + WD Sbjct: 258 STAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDL 317 Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEF-ILATGSADKTVALWDLRNLKLKLHS---F 313 + +D T + LS S +LA GS+ + + L D R + Sbjct: 318 VTARC------IDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQL 371 Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 HK+ + + P NE IL S D + VWD+ + + + G Sbjct: 372 IGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKS------VQKGV 425 Query: 374 TAKISDFSWNPNEPWVICSVSEDNIMQV 401 K+ W E I S +D +Q+ Sbjct: 426 NDKVFAVKWA--EKVGIISAGQDKKIQI 451 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 36/95 (37%), Gaps = 4/95 (4%) Query: 110 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP 169 S K+ + I H+ V+ P+N I+ + + V V+D + E Sbjct: 361 GASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKS 420 Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICL 204 +G + + + W + ++SA D I + Sbjct: 421 VQ--KGVNDKVFAVKWAEKVG--IISAGQDKKIQI 451 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 17/45 (37%), Gaps = 1/45 (2%) Query: 364 PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 P + +S + I S S D I++ W ++ N+ Sbjct: 93 PPSYLNSFSNEDWVSSLDV-GDGSKHIISGSYDGIVRTWDLSGNV 136 >5CXC-A nrPDB Length = 510 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 111/325 (34%), Gaps = 41/325 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H + A+++ + +A+ V V+ YT+ +GE P L L GH Sbjct: 190 GHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTESDHF---TGELKPTLELYGHTGSVD 244 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKE--------GKVVDAKTIFTG-------- 225 L + + S H+L+AS D I W S G V + T Sbjct: 245 WLDVDGH-SKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRG 303 Query: 226 -------HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 HTA + ++ S + D + D + ++ ++ Sbjct: 304 PLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTL-TLTHPLLSLSA 362 Query: 279 LSFNPYSEFILATGSADKTVALWDLR--NLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 L+ + +LA G++ + + + D R + + + H +++ + SP NE L S Sbjct: 363 LTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSG 422 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D VWDL + E + G E +++ I SW + Sbjct: 423 SHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYV-------IERESWASKGKKKRPVAGDG 475 Query: 397 NIMQ--VWQMAENIYNDEDPEGSVD 419 + VW ED + V+ Sbjct: 476 CKVFSVVWDKLGIFSGGEDKKVQVN 500 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 46/282 (16%), Positives = 82/282 (29%), Gaps = 73/282 (25%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 +LSAS D + +W+ S GHTA ++ + S D+ Sbjct: 160 RVLSASYDGLLRIWNASGSVI---ATSPSGSHGGHTASIKAAKFLTSDR--LASAGMDRT 214 Query: 252 LMIWDTRSNNT----SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---- 303 + +W ++ KP+ + HT V+ L + +S+ IL T SAD + W Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKAS 273 Query: 304 -----------------RNLKLKLHSFES--------HKDEIFQVQWSPHNETILASSGT 338 R + + + H + P + T+ S+ Sbjct: 274 APEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQ 333 Query: 339 DRRLNVWDLSKIGEEQSPEDAE----------------------------------DGPP 364 D + DL+ + Sbjct: 334 DHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT 393 Query: 365 ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + GH K+ S +P + + S S D +VW + Sbjct: 394 TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 93/274 (33%), Gaps = 59/274 (21%) Query: 120 KINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG---- 175 H G V+ + I+ T + + + +K S P+P P + Sbjct: 236 LYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASK-ASAPEPDASLLPGAHVSKRRKA 293 Query: 176 -----------------HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD 218 H ++P SAS DHT+ D++ G+VV Sbjct: 294 TSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTT----GQVVS 349 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 T T + ++ L + + + + D R+++ + ++ H +V Sbjct: 350 TLT-LTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVS 408 Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLK----------------------------LKL 310 LS +P +E+ L +GS D T +WDLR+++ K Sbjct: 409 LSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKK 468 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 ++F V W + S G D+++ V Sbjct: 469 RPVAGDGCKVFSVVWDKLG---IFSGGEDKKVQV 499 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 64/199 (32%), Gaps = 26/199 (13%) Query: 237 LLHESLFGSVADDQKLMIWDTRSNN-TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 + S + D L IW+ + + PS S HTA + F + LA+ D Sbjct: 155 QPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF--LTSDRLASAGMD 212 Query: 296 KTVALWDLRNLK------LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 +TV +W H + + H++ IL ++ D + W SK Sbjct: 213 RTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASK 271 Query: 350 IG----------------EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV 393 ++ L + HTA + ++P + V S Sbjct: 272 ASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSA 331 Query: 394 SEDNIMQVWQMAENIYNDE 412 S+D+ ++ + Sbjct: 332 SQDHTVRTLDLTTGQVVST 350 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 62/163 (38%), Gaps = 33/163 (20%) Query: 282 NPYSEFILATG-SADKTVALWDLRNLKLKLHS-FESHKDEIFQVQW----SPHNETI--- 332 + +++ + G S + T+ L +R+L ++ H D + V SP Sbjct: 89 SSLEDYLTSNGLSLETTLTLQYVRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRWSSAA 148 Query: 333 ------------LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 380 + S+ D L +W+ S SP + HGGHTA I Sbjct: 149 NSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGS----------HGGHTASIKAA 198 Query: 381 SWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQ 423 + ++ + S D ++VW+ E+ + + + +++ G Sbjct: 199 KFLTSDR--LASAGMDRTVRVWKYTESDHFTGELKPTLELYGH 239 >4XFV-A nrPDB Length = 792 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 101/300 (33%), Gaps = 49/300 (16%) Query: 140 IATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDD 199 I + ++D P L+GH+ E + + P+ S ++SAS+D Sbjct: 33 IVAFGAGKTIALWD-------PIEPNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASED 84 Query: 200 HTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW---- 255 H + +W + + + ++ + +S SL D + IW Sbjct: 85 HHVKIWKFT----DYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNI 137 Query: 256 -DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW-----DLRNLKLK 309 + + + LS +++LA G + V + D K + Sbjct: 138 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 197 Query: 310 -LHSFESHKDEIFQVQWSPH---NETILASSGTDRRLNVW-----DLSKIGEEQSPEDAE 360 + E H+D + + + + +L S DR + +W DL EE S + Sbjct: 198 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 257 Query: 361 DGPPELLFIHG--------------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + F GH IS W+ + ++ + + D + VW+ E Sbjct: 258 LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATA-DTSLMVWEPDE 316 Score = 87.9 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 46/232 (19%), Positives = 91/232 (39%), Gaps = 33/232 (14%) Query: 200 HTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS 259 TI LWD P E GH A V V + S ++D + IW Sbjct: 40 KTIALWD----PIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTD 94 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKLHSFESHK 317 + + ++ ++ + LS P +++ G AD T+++W +++N + L +H+ Sbjct: 95 YSHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGL----AHE 147 Query: 318 DEI-------FQVQWSP--HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 I + S + +LA GT +++ D+ ++ Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGT-------NVNVFIASFILSDSGIEKCRVVA 200 Query: 369 IHGGHTAKISDFSWNPNEP---WVICSVSEDNIMQVWQMAENIYNDEDPEGS 417 GH + ++ E +++CS S+D +++W++ N D+ E S Sbjct: 201 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 61/370 (16%), Positives = 114/370 (30%), Gaps = 105/370 (28%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 HE EV R++P + + + + V ++ +T ++ + K Sbjct: 61 GHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFT-------DYSHLQCIQTIQHYSKTIV 112 Query: 182 GLSWNPNLSGHLLSASD-DHTICLWDISAVPKEGKVVDAKTIFTGHTAV-VEDVSWHLLH 239 LS P+ L+S D TI +W + E + TI G +S Sbjct: 113 ALSALPS----LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEK 168 Query: 240 ESLFGSVADDQKL-----MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY---SEFILAT 291 + L + + ++ D+ + ++ H V L+F +++L + Sbjct: 169 KYLLAIGGTNVNVFIASFILSDSGIEKC-RVVAELEGHEDWVKSLAFRHQETPGDYLLCS 227 Query: 292 GSADKTVALW---------DLRNLKLKLHSFE-----------------------SHKDE 319 GS D+ + LW D KL H D Sbjct: 228 GSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 287 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWD----------------LSKIGEEQSPEDAEDGP 363 I +QW +LA++ D L VW+ +S G + + Sbjct: 288 ISSLQWHESRLQLLAATA-DTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFW 346 Query: 364 PELLFIH--------------------------------GGHTAKISDFSWNPNEPWVIC 391 L F H G T ++D +W+P+ +++ Sbjct: 347 SCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 406 Query: 392 SVSEDNIMQV 401 + S D ++ Sbjct: 407 T-SLDQTTRL 415 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 59/158 (37%), Gaps = 15/158 (9%) Query: 266 SHSVDAHTAEVNCLSFNPYSEFILATGSADKT----VALWDLRNLKLKLHSFESHKDEIF 321 + H E+ CL +P + I + ++ + ++ N + H I Sbjct: 555 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 614 Query: 322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS 381 ++++S + L S DR+ +W+ + + P HT I D Sbjct: 615 RLKFSKDGK-FLLSVCRDRKWALWERNMEDNTFELRFKNEKP---------HTRIIWDAD 664 Query: 382 WNPNE-PWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 W P E V + S D ++VW+ + +D E S+ Sbjct: 665 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 702 Score = 64.8 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 61/166 (36%), Gaps = 14/166 (8%) Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQK-----LMIWDTRSNNTSKPSHSVDAHTAEV 276 GH + + + L S + I+ T + KP+ H+ + Sbjct: 557 KLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF--HSLTI 613 Query: 277 NCLSFNPYSEFILATGSADKTVALW--DLRNLKLKLH--SFESHKDEIFQVQWSPHN-ET 331 L F+ +F+L+ D+ ALW ++ + +L + + H I+ W+P Sbjct: 614 TRLKFSKDGKFLLSV-CRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 672 Query: 332 ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 + ++ D+ + VW K + +A + + H + I Sbjct: 673 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMI 718 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 45/309 (14%), Positives = 93/309 (30%), Gaps = 56/309 (18%) Query: 122 NHEGEVNRARYMPQN---PCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR---- 174 HE V + Q ++ + + + ++ + D + L Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 263 Query: 175 -------------------GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 215 GH L W+ LL+A+ D ++ +W+ + Sbjct: 264 KFQIDDELRVGINFEALIMGHDDWISSLQWH-ESRLQLLAATADTSLMVWE---PDETSG 319 Query: 216 VVDAK-----------TIFTGHTAVVEDVSWHLLHE-SLFGSVADDQKLMIWDTRSNNTS 263 + + TG + W F + +W T+ N Sbjct: 320 IWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIIC 379 Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA-----LWDLRNLKLKLHSFES--- 315 + T +V ++++P E++LAT S D+T ++D K ++ ++ Sbjct: 380 DQRLGISGATKDVTDIAWSPSGEYLLAT-SLDQTTRLFAPWIYDASGRKREIATWHEFSR 438 Query: 316 ---HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 H ++ V+ S G ++ L +DL K + E + Sbjct: 439 PQIHGYDMICVETVTDTR--FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDS 496 Query: 373 HTAKISDFS 381 T + S Sbjct: 497 ATVPVLGLS 505 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/190 (14%), Positives = 67/190 (35%), Gaps = 18/190 (9%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H + R ++ ++ + + +++ + + + H + + Sbjct: 609 HSLTITRLKF-SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-----HTRIIWD 662 Query: 183 LSWNP-NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL--H 239 W P ++AS D T+ +W P + V++A HT V +S H Sbjct: 663 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK---HTKAVTAISIHDSMIR 719 Query: 240 ESLFGSVA-DDQKLMIWDTRSN--NTSKPSHSVDAHTAEVNCLSFNP---YSEFILATGS 293 E + SV ++ ++ ++ + ++ L ++ + L GS Sbjct: 720 EKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGS 779 Query: 294 ADKTVALWDL 303 +D + ++ L Sbjct: 780 SDLSTRIYSL 789 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 95/284 (33%), Gaps = 55/284 (19%) Query: 159 SKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTIC-----LWDISAVPKE 213 + C+ L + G K+ ++W+P+ +LL+ S D T ++D S +E Sbjct: 371 WATKDNIICDQRLGISGATKDVTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKRE 429 Query: 214 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHT 273 + H + V + ++ F S D++ L +D Sbjct: 430 IATWHEFSRPQIHGYDMICVE--TVTDTRFVSGGDEKILRSFDLPKGVAGM-LQKFVGIQ 486 Query: 274 AEVNCLSFNPYSEFILATGSADKT-------------------------VALWDLRNL-- 306 E P S + G ++K ++L + + Sbjct: 487 FEEKSE--MPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED 544 Query: 307 -------KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 ++ H EI + SP + ++AS+ + + + S E+ Sbjct: 545 QLQRHLLWPEVEKLYGHGFEITCLDISPD-QKLIASACRSNNVQ----NAVIRIFSTENW 599 Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + P L F H+ I+ ++ + +++ SV D +W+ Sbjct: 600 LEIKPALPF----HSLTITRLKFSKDGKFLL-SVCRDRKWALWE 638 >3F3P-A nrPDB Length = 351 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 114/336 (33%), Gaps = 60/336 (17%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 H+ V+ Y +AT + + VF K S + S R H Sbjct: 9 GHDDLVHDVVY-DFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSW------RAHDSSIV 61 Query: 182 GLSW-NPNLSGHLLSASDDHTICLWDISAVPKE--GKVVDAKTIFTGHTAVVEDVSWHLL 238 + W +P + SAS D T+ LW+ +E G+ + + V + Sbjct: 62 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 121 Query: 239 HESL-FGSVADDQKLMIW------DTRSNNTSKPSHSVD----AHTAEVNCLSFNP--YS 285 H L + +D L ++ D RS + + H CLS+ P +S Sbjct: 122 HLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFS 181 Query: 286 EFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPH-NET--ILASSGTDRR 341 LA + ++ + ++ KL + HK I + W+P ++A+ D R Sbjct: 182 PEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 241 Query: 342 LNVWDL--------------------------------SKIGEEQSPEDAEDGPPELLFI 369 + ++ + S E+ E + ELL Sbjct: 242 IRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 301 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 H H ++ SWN ++ S +D +++W+ Sbjct: 302 HDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWKAT 336 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 48/154 (31%), Gaps = 43/154 (27%) Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG---HLLSASDDHTICLWDIS-------- 208 + G+ + +L GH+ +SW P++ + + D I ++ I+ Sbjct: 197 QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS 256 Query: 209 -------------------------------AVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 A + V+ + H V VSW+L Sbjct: 257 EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL 316 Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA 271 + S DD K+ +W +N K + A Sbjct: 317 TGT-ILSSAGDDGKVRLWKATYSNEFKCMSVITA 349 >5A9Q-7 nrPDB Length = 360 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 117/308 (37%), Gaps = 39/308 (12%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H+ ++ + + +AT + V V+D ++ SG+ + + H + Sbjct: 11 HKDLIHDVSF-DFHGRRMATCSSDQSVKVWDKSE-------SGDWHCTASWKTHSGSVWR 62 Query: 183 LSW-NPNLSGHLLSASDDHTICLWDISAVPKEGKV-----VDAKTIFTGHTAVVEDVSWH 236 ++W +P L S S D T +W+ K+ +T V DV + Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 237 LLHESL-FGSVADDQKLMIW---DTRSNNTSKPSHSVDAHTAEVNCLSFNPYS----EFI 288 H L + + D + I+ D + + H + +C+S+NP S + Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLSCSCISWNPSSSRAHSPM 181 Query: 289 LATGSADK------TVALWDLRNLKLKLH---SFESHKDEIFQVQWSPHNET---ILASS 336 +A GS D V +++ K + + D + + ++P+ ILA + Sbjct: 182 IAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIA 241 Query: 337 GTDRRLNVWDLSKIGEEQSPEDA-EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 D + ++ L + +E + ++ H +++ SWN V+ S + Sbjct: 242 TKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGT-VLASSGD 298 Query: 396 DNIMQVWQ 403 D +++W+ Sbjct: 299 DGCVRLWK 306 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 101/266 (37%), Gaps = 37/266 (13%) Query: 123 HEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGE--CNPDLRLRGHQKE 179 H G V R + P+ ++A+ + V++ S G+ L + Sbjct: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115 Query: 180 GYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 + + P G +L + S D + +++ V + I +SW+ Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC--KLSCSCISWNPS 173 Query: 239 ----HESLFGSVADDQK------LMIWDTRSNN-TSKPSHSVDAHTAEVNCLSFNPY--- 284 H + +DD + I++ N + ++ T V+ ++F P Sbjct: 174 SSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGR 233 Query: 285 SEFILATGSADKTVALWDLRNLKLKLHS--------------FESHKDEIFQVQWSPHNE 330 S ILA + D V ++ L+ ++ +L S F++H ++++V W+ Sbjct: 234 SFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITG- 290 Query: 331 TILASSGTDRRLNVWDLSKIGEEQSP 356 T+LASSG D + +W + + + Sbjct: 291 TVLASSGDDGCVRLWKANYMDNWKCT 316 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 71/208 (34%), Gaps = 26/208 (12%) Query: 101 EKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSD------VLVFDY 154 E + S + EI K++ + +IA + S V +F+Y Sbjct: 143 EAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202 Query: 155 TKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG---HLLSASDDHTICLWDISAVP 211 ++ K + + +++ PNL L A+ D + ++ + V Sbjct: 203 NENTRKYAKAETLMTV------TDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVR 254 Query: 212 KEGKV--------VDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS 263 KE + F H + V VSW++ + S DD + +W + Sbjct: 255 KELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGT-VLASSGDDGCVRLWKANYMDNW 313 Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILAT 291 K + + + + VN S S L + Sbjct: 314 KCTGILKGNGSPVNGSSQQGTSNPSLGS 341 >6GMH-W nrPDB Length = 305 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 59/312 (18%), Positives = 119/312 (38%), Gaps = 46/312 (14%) Query: 122 NHEGEVNRARY---MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQK 178 H+ + + +N + T + V V+ + S L GHQ Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWS--------LEGHQL 65 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL 238 + + + S+S D I LWD+ K+ K +DA + +++ Sbjct: 66 GVVSVDIS-HTLPIAASSSLDAHIRLWDLENG-KQIKSIDAGPV------DAWTLAFSP- 116 Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 + K+ I+ S K +S+D + ++++P ++ LA+G+ D + Sbjct: 117 DSQYLATGTHVGKVNIFGVESG---KKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGII 172 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 ++D+ KL LH+ E H I + +SP +L ++ D + ++D+ Sbjct: 173 NIFDIATGKL-LHTLEGHAMPIRSLTFSPD-SQLLVTASDDGYIKIYDVQHA-------- 222 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI-----YNDED 413 L GH + + + ++ P++ S S D ++VW + ++ +D Sbjct: 223 ------NLAGTLSGHASWVLNVAFCPDDTH-FVSSSSDKSVKVWDVGTRTCVHTFFDHQD 275 Query: 414 PEGSVDPEGQGS 425 V G GS Sbjct: 276 QVWGVKYNGNGS 287 Score = 87.9 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 100/222 (45%), Gaps = 26/222 (11%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 + + P + +AT T V +F SG+ L RG K +++ Sbjct: 108 DAWTLAFSP-DSQYLATGTHVGKVNIFGV--------ESGKKEYSLDTRG--KFILSIAY 156 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 +P+ +L S + D I ++DI+ GH + +++ L + Sbjct: 157 SPD-GKYLASGAIDGIINIFDIATG-------KLLHTLEGHAMPIRSLTFSP-DSQLLVT 207 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 +DD + I+D + N + ++ H + V ++F P + S+DK+V +WD+ Sbjct: 208 ASDDGYIKIYDVQHANLA---GTLSGHASWVLNVAFCPDDTH-FVSSSSDKSVKVWDVGT 263 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 + +H+F H+D+++ V+++ + I+ S G D+ ++++D Sbjct: 264 -RTCVHTFFDHQDQVWGVKYNGNGSKIV-SVGDDQEIHIYDC 303 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 37/109 (33%), Gaps = 16/109 (14%) Query: 314 ESHKDEIFQVQWSPH---NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 ++H D I+ V W + N + + D + VW D +L + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWR------------DERLDLQWSL 60 Query: 371 GGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 GH + + P + S S D +++W + G VD Sbjct: 61 EGHQLGVVSVDISHTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVD 108 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 22/55 (40%), Gaps = 4/55 (7%) Query: 366 LLFIHGGHTAKISDFSWNPNEP---WVICSVSEDNIMQVWQMA-ENIYNDEDPEG 416 L H I +W N+ + + S D++++VW+ E + EG Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG 62 >6BX3-A nrPDB Length = 314 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 105/271 (38%), Gaps = 28/271 (10%) Query: 141 ATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDH 200 A +P L + D + + H + L W+P+ + +ASDD Sbjct: 18 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD-GQCIATASDDF 76 Query: 201 TICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 260 ++ + +S F GHTA V ++++ LF S + D+ + IWDT + Sbjct: 77 SVEIIHLSYG--------LLHTFIGHTAPVISLTFNRKGNLLFTS-SMDESIKIWDTLNG 127 Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 319 + K ++ AH+ V + IL++GS D + ++D L + KD Sbjct: 128 SLMK---TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC-LKTLTYDKDWK 183 Query: 320 -------IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 I QV++S + +L S D + +WD ++ + P E +H Sbjct: 184 RENGVVPISQVKFSENARYLLVKS-LDGVVKIWDCIGGCVVRTFQVQ---PLEKGVLH-- 237 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 H+ + + ++ S E+ + W Sbjct: 238 HSCGMDFLNPEDGSTPLVISGYENGDIYCWN 268 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 94/230 (40%), Gaps = 22/230 (9%) Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 +P+ G L+ + I ++DI+ + ++T+ T H ++ W + Sbjct: 16 TCAKISPD--GQFLAITQGLNILIYDIN------RRTVSQTLVTSHARPFSELCWSPDGQ 67 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + +DD + I + + H+ HTA V L+FN + T S D+++ + Sbjct: 68 -CIATASDDFSVEI----IHLSYGLLHTFIGHTAPVISLTFNRKGNLLF-TSSMDESIKI 121 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 WD N L + + +H + + V ++ +IL+S D + ++D ++ + Sbjct: 122 WDTLNGSL-MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 180 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYN 410 D E + IS ++ N +++ S D ++++W Sbjct: 181 DWKRENGVVP------ISQVKFSENARYLLVK-SLDGVVKIWDCIGGCVV 223 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 72/238 (30%), Gaps = 29/238 (12%) Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180 I H V + + ++ T + + ++D + H + Sbjct: 92 IGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKT----------ISAHSEAV 140 Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV--EDVSWHLL 238 + N S L S S D I ++D K + + VV V + Sbjct: 141 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHC-LKTLTYDKDWKRENGVVPISQVKFSEN 199 Query: 239 HESLFGSVADDQKLMIWD------TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 L + D + IWD R+ V H+ ++ L+ S ++ +G Sbjct: 200 ARYLLVK-SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 258 Query: 293 SADKTVALWDLRNLKLKLHSFES----HKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 + + W+ + K L + H + + I+ S + +W Sbjct: 259 YENGDIYCWN-SDTKSLLQLLDGSLYHHSSPVMSIHCF---GNIMCSLALNGDCCLWR 312 >5WBU-D nrPDB Length = 328 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 45/288 (15%), Positives = 102/288 (35%), Gaps = 37/288 (12%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 + + +VN P + +IA + ++D S NP + G K Sbjct: 42 HQDSQVNALEVTP-DRSMIAAAGYQH-IRMYDLN--------SNNPNPIISYDGVNKNIA 91 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + ++ + + + +D T +WD+ + + + + IF A + V H Sbjct: 92 SVGFHED-GRWMYTGGEDCTARIWDLRS-----RNLQCQRIFQV-NAPINCVCLHPNQAE 144 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 L + IWD ++++ + + + +P + ++ A S +W Sbjct: 145 LIV-GDQSGAIHIWDLKTDHNEQLIPEPEV---SITSAHIDPDASYMAAVNST-GNCYVW 199 Query: 302 DLR-------NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 +L + +H Q ++SP T+LA+ D+ +W S Sbjct: 200 NLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATCSADQTCKIWRTSNFSLMT 258 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 P E + +++ + +++ + S DN+ ++W Sbjct: 259 ELSIKSGNPGESS------RGWMWGCAFSGDSQYIV-TASSDNLARLW 299 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 97/272 (35%), Gaps = 32/272 (11%) Query: 136 NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQ-KEGYGLSWNPNLSGHLL 194 +P I+AT V + SG C R HQ + L P+ S + Sbjct: 13 DPVILATAGYDHTVRFW--------QAHSGICT---RTVQHQDSQVNALEVTPDRS-MIA 60 Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI 254 +A H I ++D+++ + G + V +H ++ + +D I Sbjct: 61 AAGYQH-IRMYDLNSNNPN-----PIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARI 113 Query: 255 WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE 314 WD RS N + A +NC+ +P ++ G + +WDL+ + E Sbjct: 114 WDLRSRN-LQCQRIFQV-NAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPE 170 Query: 315 SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374 I P + +A+ + VW+L+ ++ + HT Sbjct: 171 PEVS-ITSAHIDPD-ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIP------AHT 222 Query: 375 AKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 ++P+ ++ + S D ++W+ + Sbjct: 223 RYALQCRFSPDST-LLATCSADQTCKIWRTSN 253 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 75/220 (34%), Gaps = 27/220 (12%) Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 L +A DHT+ W + + V + S+ + Q Sbjct: 16 ILATAGYDHTVRFW-------QAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGY-QH 66 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 + ++D SNN P S D + + F+ ++ TG D T +WDLR+ L+ Sbjct: 67 IRMYDLNSNN-PNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQ 124 Query: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371 I V P+ ++ +++WDL EQ + E Sbjct: 125 RIFQVNAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEV---------- 173 Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYND 411 I+ +P+ ++ S N VW + I ++ Sbjct: 174 ----SITSAHIDPDASYMAAVNSTGN-CYVWNLTGGIGDE 208 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 59/186 (31%), Gaps = 21/186 (11%) Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 297 + + D + W S ++ D+ +VN L P I A G Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDS---QVNALEVTPDRSMIAAAGYQH-- 66 Query: 298 VALWDL-RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 + ++DL N + S++ I V + + + G D +WDL + Sbjct: 67 IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQR 125 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 + P I+ +PN+ +I + + +W + + PE Sbjct: 126 IFQVNAP-------------INCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEP 171 Query: 417 SVDPEG 422 V Sbjct: 172 EVSITS 177 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 80/255 (31%), Gaps = 48/255 (18%) Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 T ++D + + N + +PN + ++ Sbjct: 104 TGGEDCTARIWDLRSRNLQCQRIFQVN---------APINCVCLHPNQAELIV-GDQSGA 153 Query: 202 ICLWDISAVPKEGKVVDAKTIFTG-HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 260 I +WD+ E + + + T H S +V +W+ Sbjct: 154 IHIWDLKTDHNEQLIPEPEVSITSAHIDP---------DASYMAAVNSTGNCYVWNLTGG 204 Query: 261 -----NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL----- 310 P + AHT F+P S +LAT SAD+T +W N L Sbjct: 205 IGDEVTQLIPKTKIPAHTRYALQCRFSPDS-TLLATCSADQTCKIWRTSNFSLMTELSIK 263 Query: 311 --HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 + ES + ++ +S + + ++ +D +W + E+ Sbjct: 264 SGNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVETG--------------EIKR 308 Query: 369 IHGGHTAKISDFSWN 383 +GGH + ++N Sbjct: 309 EYGGHQKAVVCLAFN 323 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 46/118 (38%), Gaps = 17/118 (14%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPD---PSGECNPDLRLRGHQK 178 H + R+ P + ++AT + ++ + + SG R Sbjct: 220 AHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR-----G 273 Query: 179 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 +G +++ + S ++++AS D+ LW + + K + GH V ++++ Sbjct: 274 WMWGCAFSGD-SQYIVTASSDNLARLWCVETG-------EIKREYGGHQKAVVCLAFN 323 >5WYJ-BE nrPDB Length = 939 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 71/424 (16%), Positives = 158/424 (37%), Gaps = 73/424 (17%) Query: 45 LTAQWLPDVTRPEGKDFSIHRLVLGTHTS-----DEQNHLVIASVQLPNDDAQFDASHYD 99 T+ PD + + LGT T + + I ++++P ++ + + Sbjct: 200 FTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQ--SRISSLSFR 257 Query: 100 SEKGEFGGFGSVSGK-----------IEIEIKINHE--GEVNRARYMPQNPCIIATKTPS 146 ++ G+ SG I + I+ E G V +A ++ P I+ + + Sbjct: 258 TDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDN 317 Query: 147 S-DVLVFDYTKHPSKPDPSGECNPDLRLRG-HQKEGYGLSWNPNLSGHLLSASDDHTICL 204 S VFD + D + LR RG H + +++ + S +LSAS D + L Sbjct: 318 SLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--L 375 Query: 205 WDISAVPKEGKVVDAKTIFT----GH-------TAVVEDVSWHLLH------ESLFGSVA 247 W S ++ + G + E V+ + + E++ + Sbjct: 376 WSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHK 435 Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307 D++ WD R+ + + V ++ + F GS++ ++ ++++++ Sbjct: 436 DEKFARTWDMRNKRVGRWTFDTT-DDGFVKSVAMSQCGNFGFI-GSSNGSITIYNMQSGI 493 Query: 308 LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG---------------- 351 L+ ++ HK + + N ++ S G D + +D +K Sbjct: 494 LRKK-YKLHKRAVTGISLDGMNRKMV-SCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVY 551 Query: 352 -----------EEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400 ++ S + ++ GH+ +I+ F ++P W++ S S D+ ++ Sbjct: 552 HRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIR 610 Query: 401 VWQM 404 W + Sbjct: 611 TWDL 614 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 31/170 (18%), Positives = 67/170 (39%), Gaps = 16/170 (9%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H++ G+S + ++ ++S D + +D + GK+ A + + + Sbjct: 501 HKRAVTGISLDG-MNRKMVSCGLDGIVGFYDFNKSTLLGKLKL--------DAPITAMVY 551 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 H LF DD +++ D T + + H+ + F+P +I+ + S D Sbjct: 552 H-RSSDLFALALDDLSIVVIDA---VTQRVVRQLWGHSNRITAFDFSPEGRWIV-SASLD 606 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345 T+ WDL + V++SP+ + + + T + +W Sbjct: 607 STIRTWDLPTGGCIDGIIVDNVA--TNVKFSPNGDLLATTHVTGNGICIW 654 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 37/290 (12%), Positives = 91/290 (31%), Gaps = 47/290 (16%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 G V + + P I+A ++ + ++ K + K + Sbjct: 400 GRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMR-----NKRVGRWT 454 Query: 185 WNPNLSGHLLS------------ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232 ++ G + S S + +I ++++ + + + H V Sbjct: 455 FDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNM-------QSGILRKKYKLHKRAVTG 507 Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 +S ++ + S D + +D + A + + ++ S+ + A Sbjct: 508 ISLDGMNRKMV-SCGLDGIVGFYDFNKSTLLGKLKL----DAPITAMVYHRSSD-LFALA 561 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 D ++ + D ++ + H + I +SP I+ S+ D + WDL G Sbjct: 562 LDDLSIVVIDAVTQRV-VRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTWDLPTGGC 619 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 ++ ++PN + + N + +W Sbjct: 620 IDGIIV---------------DNVATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 76/179 (42%), Gaps = 10/179 (5%) Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + ++++++ R K ++ + ++ LSF L+ G++ + Sbjct: 219 DIIALGTVTGEVIMFNMRKG---KRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIF 275 Query: 301 WDLRNLKLKLHSFES-HK---DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356 +DL + + ++H ++ H+ + Q + + + I+ +SG D L + + Q Sbjct: 276 YDL-DRRSRIHVLKNIHRESYGGVTQATF-LNGQPIIVTSGGDNSLKEY-VFDPSLSQGS 332 Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 D PP L GGH+ S ++ ++ + S S+D + + + ++ + E + Sbjct: 333 GDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQ 391 >1PI6-A nrPDB Length = 615 Score = 94.5 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 88/255 (34%), Gaps = 25/255 (9%) Query: 161 PDPSGECNPDLRLRGH-QKEGYGLSWNP-NLSGHLLSASDDHTICLWDISAVPKEGKV-V 217 D + P ++ GH + ++P S +L S + + +W + + V V Sbjct: 47 DDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEV 106 Query: 218 DAKTIFTGHTAVVEDVSWHLLHESLFGSV-ADDQKLMI--WDTRSNNTSKPSHSVDAHTA 274 + K+ F + D+SW L D + WD + V H+ Sbjct: 107 NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD-----SGNSLGEVSGHSQ 161 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK--DEIFQVQWSPHNETI 332 +N T D +V + K HK + V++SP + Sbjct: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 + + G+DR+++ +D + ED ++ +F + + + + Sbjct: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIF------------ALSWLDSQKFAT 269 Query: 393 VSEDNIMQVWQMAEN 407 V D ++VW + + Sbjct: 270 VGADATIRVWDVTTS 284 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 49/325 (15%), Positives = 105/325 (32%), Gaps = 44/325 (13%) Query: 100 SEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 159 + FG F S + H +N P T V+ + Sbjct: 136 EGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY------- 188 Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 + P D + ++P+ +++ D I +D + + D Sbjct: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDD 248 Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK--PSHSVDAHTAEVN 277 + G + +SW L F +V D + +WD ++ + +V Sbjct: 249 QEPVQG---GIFALSW--LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 ++ + + S D T+ ++L + ++ L + H I + +P L S Sbjct: 304 VVA---TGNGRIISLSLDGTLNFYELGHDEV-LKTISGHNKGITALTVNP-----LISGS 354 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 397 D R+ W S +H H+ I + + + S+S D+ Sbjct: 355 YDGRIMEWSSSS-------------------MHQDHSNLIVSLDNSKAQEY--SSISWDD 393 Query: 398 IMQVWQMAENIYNDEDPEGSVDPEG 422 ++V + ++ + + S + +G Sbjct: 394 TLKVNGITKHEFGSQPKVASANNDG 418 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 53/119 (44%), Gaps = 13/119 (10%) Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF---------I 288 E+ + K++++D +S + T+++N +S+ P + + Sbjct: 498 PSETYIAAGDVMGKILLYDLQSREVKTSRWAFR--TSKINAISWKPAEKGANEEEIEEDL 555 Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 +ATGS D + ++ ++ + + +HKD + + W + L SSG D + W++ Sbjct: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWNV 612 >6CHG-A nrPDB Length = 312 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 54/274 (19%), Positives = 98/274 (35%), Gaps = 36/274 (13%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 H+ +N + P + CI A+ + V + RL GH Sbjct: 53 HKECINCLCWSPDSKCI-ASGSEDFTVEITHIIYGR-----------IRRLMGHTAPVIS 100 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + +N N L S+S D +I W + + A + H+ V + S+ Sbjct: 101 ICYN-NKGNILCSSSMDESIKEWHVLSG-------TALKTMSAHSDAVVSIDIPKFDSSI 152 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE-----VNCLSFNPYSEFILATGSADKT 297 S + D + I+DT S + K AE ++ + F+ +F+L S D Sbjct: 153 LSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVK-SLDNV 211 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWS-------PHNETILASSGTD-RRLNVWDLSK 349 V LW+ + H++ +++++ P + L SG D + VW++ Sbjct: 212 VKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYS 271 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 Q ++ P L K++ S N Sbjct: 272 KNLVQKIDEKHRNSP--LISISASYDKVATLSLN 303 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 62/177 (35%), Gaps = 23/177 (12%) Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 E + D + ++ S+ K + + H +NCL ++P S+ I A Sbjct: 17 TSCQISPDGELIAICQNTDMLV--YEISSSKMMKLTTT---HKECINCLCWSPDSKCI-A 70 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 +GS D TV + + + + H + + ++ + IL SS D + W + Sbjct: 71 SGSEDFTVEITHIIYGR--IRRLMGHTAPVISICYN-NKGNILCSSSMDESIKEWHVLSG 127 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 L H+ + + ++ S S D +++++ Sbjct: 128 T--------------ALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESG 170 Score = 55.2 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 27/132 (20%), Positives = 50/132 (37%), Gaps = 20/132 (15%) Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 +P E I + D V +++ + K+ + HK+ I + WSP ++ I AS Sbjct: 17 TSCQISPDGELIAICQNTDMLV--YEISSSKMMKLTTT-HKECINCLCWSPDSKCI-ASG 72 Query: 337 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 396 D + + + GHTA + +N N+ ++CS S D Sbjct: 73 SEDFTVEI---------------THIIYGRIRRLMGHTAPVISICYN-NKGNILCSSSMD 116 Query: 397 NIMQVWQMAENI 408 ++ W + Sbjct: 117 ESIKEWHVLSGT 128 >5N4A-A nrPDB Length = 771 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 80/233 (34%), Gaps = 26/233 (11%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H + + WN + L + SDD TI W++ P++ H V Sbjct: 13 HSELTAAVGWN--VWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 +F D + I + T + S++ H L ++ LAT D Sbjct: 71 QAGGTDVFAVACTDGSVKI----LSRTGRVEKSIEGHKGACISLRWSYDG-TALATAGED 125 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 355 +V +W RN L+ ++ ++ + W+ + + +G++ + Sbjct: 126 GSVKIWS-RNGMLRSTLAQADS-PVYSIVWAYDCDQLCYCTGSNVVIK----------SL 173 Query: 356 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 +A+ + H + W+P +I + ED +VW + Sbjct: 174 SSNAKQNAWK------AHDGVVLKVDWSP-INHLIITGGEDCKYKVWDSFGRL 219 Score = 81.0 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 36/220 (16%), Positives = 73/220 (33%), Gaps = 33/220 (15%) Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 229 + + GH+ L W+ + L +A +D ++ +W + ++ + Sbjct: 97 EKSIEGHKGACISLRWSYD-GTALATAGEDGSVKIWS--------RNGMLRSTLAQADSP 147 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289 V + W + L + + S +++ ++ AH V + ++P + I+ Sbjct: 148 VYSIVWAYDCDQLCYCTGSNVVIK-----SLSSNAKQNAWKAHDGVVLKVDWSPINHLII 202 Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 TG D +WD L + + V W+P E + A G L + Sbjct: 203 -TGGEDCKYKVWDSFGRLLFQSGLFDY--PVTSVAWAPSGE-LFAVGGF-NTLQL----- 252 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 + IH T I SW + + Sbjct: 253 ---------CDRMGWAYSKIHLNDTGSIMTLSWTADSTQL 283 >4U1E-I nrPDB Length = 347 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 49/335 (14%), Positives = 107/335 (31%), Gaps = 78/335 (23%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 HE + + +Y + ++ + + S V+ L GH + Sbjct: 8 GHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERLGT----------LDGHTGTIW 56 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + + ++ S D++I LWD+S V+ V + Sbjct: 57 SIDVD-CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV--------PVKRVEFSPCGNY 107 Query: 242 LFGSVAD----DQKLMIWDTR--------SNNTSKPSHSVDAHT--AEVNCLSFNPYSEF 287 + + + I++ + + +P H + H ++ ++ Sbjct: 108 FLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKY 167 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL 347 I+A G D ++ +D+ N + S + H+ I +Q+SP + SS V D+ Sbjct: 168 IIA-GHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLV-DV 225 Query: 348 SKI-------------------------------GEEQSPEDAEDGPPELLFIH------ 370 S + ++ + A +G E F H Sbjct: 226 STLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEE 285 Query: 371 ----GGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 GH ++ + +P S ED +++ Sbjct: 286 IGRVQGHFGPLNTVAISPQGTSY-ASGGEDGFIRL 319 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 82/246 (33%), Gaps = 43/246 (17%) Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 231 +L GH++ + +N L S S D + +W + G GHT + Sbjct: 5 KLTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERLG-------TLDGHTGTIW 56 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA- 290 + + + D + +WD + S V + F+P + LA Sbjct: 57 SIDVDCF-TKYCVTGSADYSIKLWDVSNGQCVATWKS----PVPVKRVEFSPCGNYFLAI 111 Query: 291 ---TGSADKTVALWDLRNLKL----------KLHSFESHK--DEIFQVQWSPHNETILAS 335 ++ ++++ +H +H+ D WS + I+A Sbjct: 112 LDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA- 170 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 D +++ +D+S E D H ISD ++P+ + I S + Sbjct: 171 GHKDGKISKYDVSNNYEYVDSIDL-------------HEKSISDMQFSPDLTYFITSSRD 217 Query: 396 DNIMQV 401 N V Sbjct: 218 TNSFLV 223 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 34/95 (35%), Gaps = 16/95 (16%) Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 H+ + QV+++ + +L S D +VW E L G Sbjct: 6 LTGHERPLTQVKYNKEGD-LLFSCSKDSSASVW--------------YSLNGERLGTLDG 50 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 HT I + + + + S D +++W ++ Sbjct: 51 HTGTIWSIDVDCFTKYCV-TGSADYSIKLWDVSNG 84 Score = 35.6 bits (80), Expect = 0.040, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 46/136 (33%), Gaps = 9/136 (6%) Query: 77 NHLVIASVQLPN---DDAQFDA--SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRAR 131 N+ + S+ L D QF +++ + + F +++ K + +N A Sbjct: 185 NYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAV 244 Query: 132 YMPQNPCIIATKT---PSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN 188 P II + K ++ R++GH ++ +P Sbjct: 245 ITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQ 304 Query: 189 LSGHLLSASDDHTICL 204 + + S +D I L Sbjct: 305 GTSY-ASGGEDGFIRL 319 >4E5Z-B nrPDB Length = 436 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 85/226 (37%), Gaps = 21/226 (9%) Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240 L+W+P + S I LW+ K + G + + ++ L+ Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFI-----KGIGAGGSITGLKFNPLNT 177 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 + F + + + + D + N + S D L + S ++ TG V L Sbjct: 178 NQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVV-TGDNVGNVIL 235 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 ++ +L + HK ++ V +P + LA++ D+ + +WDL ++ Sbjct: 236 LNM--DGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV---------- 283 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 H ++ ++P+ ++ + + + ++V+ ++ Sbjct: 284 -RGKASFLYSLPHRHPVNAACFSPDGARLL-TTDQKSEIRVYSASQ 327 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 47/319 (14%), Positives = 91/319 (28%), Gaps = 57/319 (17%) Query: 128 NRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNP 187 + P +P +A + D++++++ G G GL +NP Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKG--------IGAGGSITGLKFNP 174 Query: 188 NLSGHLLSASDDHT-------------------ICLW----DISAVPKEGKVVDAKTI-- 222 + ++S + T I +W D+SA + D Sbjct: 175 LNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 234 Query: 223 -----------FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA 271 H V V+ + + + + DQ + IWD R Sbjct: 235 LLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 294 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL------HSFESHKDEIFQVQW 325 H VN F+P +L T + ++ L H H I W Sbjct: 295 HRHPVNAACFSPDGARLLTT-DQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AW 352 Query: 326 SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS-WNP 384 P I+ D + + + ++ ++ IS + +NP Sbjct: 353 HPRYNLIVVGRYPDPNFK--SCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNP 410 Query: 385 NEPWVICSVSEDNIMQVWQ 403 + + + + +W Sbjct: 411 MGDTL--ASAMGYHILIWS 427 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 24/178 (13%), Positives = 56/178 (31%), Gaps = 30/178 (16%) Query: 259 SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE-SHK 317 + ++ + L+++P +A GS + LW+ Sbjct: 105 TLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG 164 Query: 318 DEIFQVQWSPHNETILASSGTDR-------------------RLNVW--DLSKIGEEQSP 356 I ++++P N +S + +N+W L + Sbjct: 165 GSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMV 224 Query: 357 EDAEDGPPELLFIHGG--------HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 ++ +L G H K++ + NP W + + S D +++W + + Sbjct: 225 VTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 282 >5A9Q-2 nrPDB Length = 326 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 55/332 (16%), Positives = 111/332 (33%), Gaps = 57/332 (17%) Query: 77 NHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQN 136 N++VI + ++A + Y + + +H V+ + P+ Sbjct: 42 NYVVIGTCTFQEEEADVEGIQYKTLRT-----------------FHHGVRVDGIAWSPET 84 Query: 137 -----PCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG 191 P +I T ++D+ + +T N L GH GL ++P Sbjct: 85 RLDSLPPVIKFCTSAADMKIRLFTSDLQDK------NEYKVLEGHTDFINGLVFDPKEGQ 138 Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQK 251 + S SDDHT +W++ V F H+ V WH + Sbjct: 139 EIASVSDDHTCRIWNLEGVQ--------TAHFVLHSPG-MSVCWHPEETFKLMVAEKNGT 189 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL-ATGSADKTVALWDLRNLKLKL 310 + +D + + S+++ + + + F + A D + WD+ Sbjct: 190 IRFYDLLAQ---QAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLI--WDITRSSYPQ 244 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 + H D +WS +E + A++G ++ + G P+ + + Sbjct: 245 NKRPVHMDRACLFRWSTISENLFATTGYPGKM----------ASQFQIHHLGHPQPILMG 294 Query: 371 GGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 SW+ P +C + D+ + W Sbjct: 295 SVAVGS--GLSWHRTLP--LCVIGGDHKLLFW 322 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 25/156 (16%), Positives = 55/156 (35%), Gaps = 27/156 (17%) Query: 259 SNNTSKPSHSVDAHTAEVNCLSFNPYSEF-------ILATGSADKTVALW--DLRNLKLK 309 K + H V+ ++++P + T +AD + L+ DL++ K + Sbjct: 59 EGIQYKTLRTFH-HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQD-KNE 116 Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 369 E H D I + + P +AS D +W+L + Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL------------ 164 Query: 370 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405 H+ + W+P E + + ++ ++ + + Sbjct: 165 ---HSPGM-SVCWHPEETFKLMVAEKNGTIRFYDLL 196 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 54/154 (35%), Gaps = 33/154 (21%) Query: 273 TAEVNCLSFNP----YSEFILATGSADKTVAL---------WDLRNLKLKLHSFESHKDE 319 V+ + FNP S ++A G + V + D+ ++ K H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGG-NNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVR 74 Query: 320 IFQVQWSPHNET-------ILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + + WSP +S D ++ + ++ + G Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRL------------FTSDLQDKNEYKVLEG 122 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 HT I+ ++P E I SVS+D+ ++W + Sbjct: 123 HTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG 156 >3I2N-A nrPDB Length = 357 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 53/352 (15%), Positives = 119/352 (33%), Gaps = 36/352 (10%) Query: 71 HTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRA 130 H N+ V +P ++ G + G +++ +I + Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCG 71 Query: 131 RY--MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPN 188 + +AT ++ +++ P ++GH++ + Sbjct: 72 TFGATSLQQRYLATGDFGGNLHIWNLEAPEM---------PVYSVKGHKEIINAIDGIGG 122 Query: 189 LSGH-----LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW---HLLHE 240 L +++ S D T+ +WD ++ + V++ + E Sbjct: 123 LGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQG--ENKRDCWTVAFGNAYNQEE 180 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY--SEFILATGSADKTV 298 + + D+ + ++D R+ ++ + V L F+ S L S + Sbjct: 181 RVVCAGYDNGDIKLFDLRNMALRWETNIKNG----VCSLEFDRKDISMNKLVATSLEGKF 236 Query: 299 ALWDLRNL----KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL-----SK 349 ++D+R S ++HK ++QV+ P N + ++G L++W Sbjct: 237 HVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRS 296 Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 + + E G LL T IS W+P++ + S D ++V Sbjct: 297 KKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 26/225 (11%), Positives = 77/225 (34%), Gaps = 29/225 (12%) Query: 191 GHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL-----FGS 245 +L + + +W++ A GH ++ + + Sbjct: 81 RYLATGDFGGNLHIWNLEAPE------MPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVT 134 Query: 246 VADDQKLMIWDTRSNNTSKPSHS-VDAHTA-EVNCLSF---NPYSEFILATGSADKTVAL 300 + D + +WD R + + V + ++F E ++ G + + L Sbjct: 135 GSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKL 194 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETI--LASSGTDRRLNVWDLSKIGEEQSPED 358 +DLRN+ L+ + + K+ + +++ + ++ L ++ + + +V+D+ + Sbjct: 195 FDLRNMALRWET--NIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFAS 252 Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + H + + P + + + +W+ Sbjct: 253 VSE---------KAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWK 288 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 23/191 (12%), Positives = 60/191 (31%), Gaps = 14/191 (7%) Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQ---KLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 280 G V D W + + +++ + + A + Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFG 74 Query: 281 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI-----LAS 335 + LATG + +W+L ++ ++S + HK+ I + + + Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVT 134 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395 D + VWD + + + + G + + E V+C+ + Sbjct: 135 GSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYN------QEERVVCAGYD 188 Query: 396 DNIMQVWQMAE 406 + ++++ + Sbjct: 189 NGDIKLFDLRN 199 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 38/100 (38%), Gaps = 9/100 (9%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPD---------LR 172 H+ V + R++PQN + T + + ++ Y + E Sbjct: 257 AHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQN 316 Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 212 + + L W+P+ G + +S D T+ + ++ + K Sbjct: 317 VTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNK 356 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 55/164 (33%), Gaps = 27/164 (16%) Query: 267 HSVDAHTAEVNCLSFNPYSEFILATGS---ADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 H V + P S + G+ + L+++++ LKL I Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCG 71 Query: 324 QWSPHN--ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS 381 + + + LA+ L++W+L + P ++ GH I+ Sbjct: 72 TFGATSLQQRYLATGDFGGNLHIWNL-------------EAPEMPVYSVKGHKEIINAID 118 Query: 382 WNPNEPWV-----ICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420 I + S D ++VW + +DP +++P Sbjct: 119 GIGGLGIGEGAPEIVTGSRDGTVKVWDPRQ----KDDPVANMEP 158 >5WLC-LJ nrPDB Length = 513 Score = 88.7 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 44/264 (16%), Positives = 83/264 (31%), Gaps = 32/264 (12%) Query: 148 DVLVFDYTKHPSKPDPSG----ECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTIC 203 ++ P + P + ++ H +S+NP S + Sbjct: 7 RIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTR-VQ 64 Query: 204 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS 263 ++ + F+ VV S+ L + + ++D+ + T Sbjct: 65 IFS-------SRTRQVIKTFSRFKDVVYSASFR-SDGKLLCAGDATGLVSVYDSYNPRTI 116 Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 323 S + H V F+ ILAT S D+ LWD+ N D + + Sbjct: 117 LLSINASTHPTHVT--KFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTL 174 Query: 324 QWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWN 383 + P ++A+ D + ++D G D P E + + + Sbjct: 175 SFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVE------------NVIAVS 222 Query: 384 PNEPWVICSVSEDNIMQVWQMAEN 407 P + I S N +VW + N Sbjct: 223 PTQ---IVSCG-GNNFKVWDLTSN 242 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 24/163 (14%), Positives = 56/163 (34%), Gaps = 30/163 (18%) Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG-YGLSW 185 V ++P P ++AT + + ++D S P S H + ++ Sbjct: 171 VRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLN---------HDQPVENVIAV 221 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-----HLLHE 240 +P ++S ++ +WD+++ K + + V + + + Sbjct: 222 SPT---QIVSCGGNN-FKVWDLTSNKKLYERGNF-------NKAVTCLDYVENFDSPMQS 270 Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 +L S + D + ++D N K V + +P Sbjct: 271 ALIAS-SLDGHVKVFDPLDNFQVKFGWKFSG---PVLSCAVSP 309 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 25/162 (15%), Positives = 61/162 (37%), Gaps = 17/162 (10%) Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317 R + V H + V +SFNP A S+ + V ++ R ++ + +F K Sbjct: 25 RYWRQYTSAQLVKEHNS-VTHISFNPQHPHDFAVTSSTR-VQIFSSRTRQV-IKTFSRFK 81 Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377 D ++ + + +L + ++V+D L H + Sbjct: 82 DVVYSASFR-SDGKLLCAGDATGLVSVYDSYNPRTIL-----------LSINASTHPTHV 129 Query: 378 SDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 + ++ + ++ + S+D + ++W ++ + G+ D Sbjct: 130 TK--FHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATD 169 >5K0Y-T nrPDB Length = 329 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 45/328 (13%), Positives = 106/328 (32%), Gaps = 72/328 (21%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 181 HE + + +Y + ++ T V V+ GH + Sbjct: 8 GHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERLGT----------YMGHTGAVW 56 Query: 182 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241 + + + H+L+ S D++ LWD + GK + + V + Sbjct: 57 CVDADWDTK-HVLTGSADNSCRLWD----CETGKQLALLKT----NSAVRTCGFDFGGNI 107 Query: 242 LFGSV----ADDQKLMIWDTRSNNT---SKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294 + S + +D R + ++P + + +++ + P E I+A G Sbjct: 108 IMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIA-GHE 166 Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354 + + ++ ++ ++ + H +I +Q S T+ ++ D ++D + + ++ Sbjct: 167 SGELNQYSAKSGEVLVNV-KEHSRQINDIQLSREM-TMFVTASKDNTAKLFDSTTLEHQK 224 Query: 355 -------------------------------SPEDAEDGPPELLFIH----------GGH 373 + G E F H GH Sbjct: 225 TFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGH 284 Query: 374 TAKISDFSWNPNEPWVICSVSEDNIMQV 401 I+ +++P+ S ED +++ Sbjct: 285 FGPINSVAFHPDGKSY-SSGGEDGYVRI 311 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 36/95 (37%), Gaps = 16/95 (16%) Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + H+ I Q++++ + +L + D +NVW E L + G Sbjct: 6 LQGHERSITQIKYNREGD-LLFTVAKDPIVNVW--------------YSVNGERLGTYMG 50 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 HT + + + V+ + S DN ++W Sbjct: 51 HTGAVWCVDADWDTKHVL-TGSADNSCRLWDCETG 84 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 17/133 (12%), Positives = 42/133 (31%), Gaps = 9/133 (6%) Query: 75 EQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMP 134 +++ I +QL + F + D+ F +E + E A P Sbjct: 185 KEHSRQINDIQLSREMTMFVTASKDNTAKLFDST-----TLEHQKTFRTEPPRELAALSP 239 Query: 135 QNPCIIATKTPSSDVLVFDYTKHPSKPDPSGEC---NPDLRLRGHQKEGYGLSWNPNLSG 191 ++ + + T+ R++GH ++++P+ Sbjct: 240 NYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKS 299 Query: 192 HLLSASDDHTICL 204 + S +D + + Sbjct: 300 Y-SSGGEDGYVRI 311 >5BJS-A nrPDB Length = 605 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 76/190 (40%), Gaps = 14/190 (7%) Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 297 + L ++ + +++ + ++ H +N L+ +P + +I+A+ S D T Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYR---TLVGHGGGINDLATSPANPYIIASASDDTT 202 Query: 298 VALWDL-----RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 + +W L + + + E H ++ V + + +L S+G D+ +N+W L + Sbjct: 203 IRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL-SAGHDQVINLWALPEFPN 261 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE-DNIMQVWQMAENIYND 411 E P H + ++ + +I S + ++ + +W++ +D Sbjct: 262 EHMEIPIVIYYPHFS-SSEIHNNLVDCVAFYGD---LILSRACHEDTIVLWRIEGFSSDD 317 Query: 412 EDPEGSVDPE 421 P P Sbjct: 318 PIPGPLDAPT 327 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 44/208 (21%), Positives = 78/208 (37%), Gaps = 29/208 (13%) Query: 116 EIEIKINHEG-EVNRARYMPQNPC----IIATKTPSSDVLVFDYTKHPSKPDPSGECNPD 170 EI I +G E N A ++P ++ +V V++ T+ Sbjct: 122 EIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLY---------- 171 Query: 171 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230 L GH L+ +P + SASDD TI +W ++ ++ V GH+ + Sbjct: 172 RTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCV-CILGGEGHSYDL 230 Query: 231 EDVSWHLLHESLFGSVADDQKLMIW----------DTRSNNTSKPSHSVDAHTAEVNCLS 280 V++H + S DQ + +W + S + H V+C++ Sbjct: 231 LSVAFHDNGRYVL-SAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVA 289 Query: 281 FNPYSEFILATGSADKTVALWDLRNLKL 308 F Y + IL+ + T+ LW + Sbjct: 290 F--YGDLILSRACHEDTIVLWRIEGFSS 315 Score = 71.0 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 63/155 (40%), Gaps = 15/155 (9%) Query: 119 IKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT-KHPSKPDPSGECNPDLRLRGHQ 177 + H G +N P NP IIA+ + + + ++ +H +P C L GH Sbjct: 173 TLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQP-----CVCILGGEGHS 227 Query: 178 KEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG------HTAVVE 231 + ++++ + ++LSA D I LW + P E + + H +V+ Sbjct: 228 YDLLSVAFH-DNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVD 286 Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPS 266 V+++ + + + +++W ++ P Sbjct: 287 CVAFY--GDLILSRACHEDTIVLWRIEGFSSDDPI 319 >3EI3-B nrPDB Length = 383 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 39/226 (17%), Positives = 83/226 (36%), Gaps = 20/226 (8%) Query: 178 KEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 + L W+P + S I LWD K + G + + ++ Sbjct: 74 RRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFI-----QGMGPGDAITGMKFNQ 128 Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 297 + + + + D S + + D+ C+ + S +LATG D T Sbjct: 129 FNTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVS-VSRQMLATG--DST 184 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE 357 L L ++ + HK ++ +++P + ++A+S D + +WDL I ++ S Sbjct: 185 GRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYI 244 Query: 358 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 H ++ +NP + + + + N ++V+ Sbjct: 245 AEMP-----------HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYS 279 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 50/319 (15%), Positives = 90/319 (28%), Gaps = 57/319 (17%) Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWN 186 V + P +P +A + D++++DY G D G+ +N Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDA--------ITGMKFN 127 Query: 187 P-NLSGHLLSA----------------------SDDHTICLWDISAVPKEGKVVDAKTIF 223 N + +S+ S D+ C D+S + D+ Sbjct: 128 QFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRL 187 Query: 224 TG-------------HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD 270 H A V ++ + L + + D + +WD R+ + Sbjct: 188 LLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEM 247 Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES------HKDEIFQVQ 324 H VN FNP L T + ++ + H I Sbjct: 248 PHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-T 306 Query: 325 WSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384 W P + I+A D +L + DA G IS ++P Sbjct: 307 WHPMYDLIVAGRYPDDQLLL----NDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSP 362 Query: 385 NEPWVICSVSEDNIMQVWQ 403 + + + +W Sbjct: 363 TGDVL--ASGMGFNILIWN 379 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 77/195 (39%), Gaps = 17/195 (8%) Query: 115 IEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR 174 EI + H+ +V A + P+ ++AT + + V ++D K E Sbjct: 195 HEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP------ 248 Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 H+K +NP S LL+ + I ++ K +++ H ++ + Sbjct: 249 -HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-T 306 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE-------VNCLSFNPYSEF 287 WH +++ + D +L++ D R+ + + H ++ F+P + Sbjct: 307 WHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGD- 365 Query: 288 ILATGSADKTVALWD 302 +LA+G + +W+ Sbjct: 366 VLASG-MGFNILIWN 379 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 33/193 (17%), Positives = 64/193 (33%), Gaps = 22/193 (11%) Query: 228 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF 287 V + WH H + + +++WD N + + + + FN ++ Sbjct: 74 RRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGM-GPGDAITGMKFNQFNTN 132 Query: 288 ILATGSADKTVALWDLRNLKLKLHSFESHKD-EIFQVQWSPHNETILASSGTDRRLNVWD 346 L S L D +++ + D V S + +LA+ D Sbjct: 133 QLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVS-VSRQMLATG--DST----- 184 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA- 405 +F H AK++ +NP W++ + S D +++W + Sbjct: 185 --------GRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRN 236 Query: 406 ---ENIYNDEDPE 415 +N Y E P Sbjct: 237 IKDKNSYIAEMPH 249 >4OWR-A nrPDB Length = 339 Score = 79.1 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 32/131 (24%), Positives = 55/131 (41%), Gaps = 15/131 (11%) Query: 179 EGYGLSWNPNL--SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 LS++P L++ S + + W++ G+ + HT V DV W Sbjct: 12 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEV---QDSGQTIPKAQQM--HTGPVLDVCWS 66 Query: 237 LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF--NPYSEFILATGSA 294 +F + + D+ +WD SN + + H A V + + P ++ TGS Sbjct: 67 DDGSKVF-TASCDKTAKMWDLSSNQAIQ----IAQHDAPVKTIHWIKAPNYSCVM-TGSW 120 Query: 295 DKTVALWDLRN 305 DKT+ WD R+ Sbjct: 121 DKTLKFWDTRS 131 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 97/289 (33%), Gaps = 68/289 (23%) Query: 152 FDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVP 211 + + SG+ P + H + W+ + + +AS D T +WD+S+ Sbjct: 33 WANDVRCWEVQDSGQTIPKAQQM-HTGPVLDVCWS-DDGSKVFTASCDKTAKMWDLSSNQ 90 Query: 212 KEGKVVDAKTIFTGHTAVVEDVSW-HLLHESLFGSVADDQKLMIWDTRSNN--------- 261 H A V+ + W + S + + D+ L WDTRS+N Sbjct: 91 --------AIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPE 142 Query: 262 ------------------TSKPSHSVDAHTAEV-----------NCLSFNPYSEFI---L 289 + ++ +E C++ + Sbjct: 143 RCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGF 202 Query: 290 ATGSADKTVALW--DLRNLKLKLHSFESHKD------------EIFQVQWSPHNETILAS 335 A GS + VA+ + N +F+ H+ + + + P + T LA+ Sbjct: 203 ALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGT-LAT 261 Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT-AKISDFSWN 383 G+D R + WD + ++ E + F H G+ A S + W+ Sbjct: 262 VGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWS 310 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 51/140 (36%), Gaps = 22/140 (15%) Query: 273 TAEVNCLSFNPYS--EFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPHN 329 + CLSF+P + L GS V W++++ + + + H + V WS Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW--NPNEP 387 + +S D+ +WDLS Q + H A + W PN Sbjct: 70 SKVFTASC-DKTAKMWDLSSNQAIQIAQ---------------HDAPVKTIHWIKAPN-Y 112 Query: 388 WVICSVSEDNIMQVWQMAEN 407 + + S D ++ W + Sbjct: 113 SCVMTGSWDKTLKFWDTRSS 132 >5MWJ-A nrPDB Length = 337 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 87/255 (34%), Gaps = 36/255 (14%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H + ++ + N + H+ + + +WDIS + V + + Sbjct: 50 HGEVVCAVTIS-NPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNR--DNYIRSCKL 105 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 +L + L IWD + T + + + L+ +P S+ + +D Sbjct: 106 LPDGCTLIV-GGEASTLSIWDLAAP-TPRIKAELTSSAPACYALAISPDSKVCF-SCCSD 162 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK------ 349 +A+WDL N L + F+ H D + S ++ T L + G D + WDL + Sbjct: 163 GNIAVWDLHNQTL-VRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQQ 220 Query: 350 --------------------IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 +G E S + + H + + + W Sbjct: 221 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW- 279 Query: 390 ICSVSEDNIMQVWQM 404 S +DN++ W+ Sbjct: 280 FVSTGKDNLLNAWRT 294 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 60/186 (32%), Gaps = 22/186 (11%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHT--AEVNCLSFNP 283 H VV V+ ++ + +WD P +D + P Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK--GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 284 YSEFILATGSADKTVALWDLRNLKLKL-HSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 L G T+++WDL ++ S + + SP ++ + S +D + Sbjct: 108 DG-CTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSK-VCFSCCSDGNI 165 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 VWDL L+ GHT S + + + + DN ++ W Sbjct: 166 AVWDLHNQT--------------LVRQFQGHTDGASCIDISNDGTK-LWTGGLDNTVRSW 210 Query: 403 QMAENI 408 + E Sbjct: 211 DLREGR 216 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 29/208 (13%), Positives = 67/208 (32%), Gaps = 32/208 (15%) Query: 142 TKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHT 201 + ++ V+D + +GH + + N L + D+T Sbjct: 158 SCCSDGNIAVWDLH----------NQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNT 206 Query: 202 ICLWDISAVPKEGKVVDAKTIFTGH--TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS 259 + WD+ + H T+ + + + E + + + Sbjct: 207 VRSWDLREGRQ----------LQQHDFTSQIFSLGYCPTGE-WLAVGMESSNVEVLHVNK 255 Query: 260 NNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 + + + H + V L F ++ ++TG D + W S E Sbjct: 256 PDKYQ----LHLHESCVLSLKFAYCGKWFVSTG-KDNLLNAWRTPYGASIFQSKE--SSS 308 Query: 320 IFQVQWSPHNETILASSGTDRRLNVWDL 347 + S ++ I+ SG D++ V+++ Sbjct: 309 VLSCDISVDDKYIVTGSG-DKKATVYEV 335 >5M89-A nrPDB Length = 329 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 44/304 (14%), Positives = 96/304 (31%), Gaps = 35/304 (11%) Query: 47 AQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFG 106 + + +V + K + G T+D+ L Q+ D + + E Sbjct: 11 VEHVNEVQQQLMKTRKKRPIPQGWATADDVAALQ----QVAYTDLNVTQASSLDLENECA 66 Query: 107 GFGSVSGKIEIEIKINHEGEVN-----RARYMPQNPCIIATKTPSSDVLVFDYTKHPSKP 161 G + GK++I + ++ E + T V V+D Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGWVKVYD-------- 118 Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221 + H GL+ +P L S D + +D+ + + Sbjct: 119 ----AGRESATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGERVARGYADAA 173 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 + ++H +LF + ++++ T + ++ + L+F Sbjct: 174 L--------TTCAFHPDG-NLFAAGTQTGHILVFHTTTLEQAESFPL----GTPIQALAF 220 Query: 282 NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRR 341 + + ATG +V ++DLR E E+ + W + + GT Sbjct: 221 SENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVT 280 Query: 342 LNVW 345 + ++ Sbjct: 281 VQMY 284 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 35/287 (12%), Positives = 82/287 (28%), Gaps = 46/287 (16%) Query: 127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHP-SKPDPSGECNPDLRLRGHQKEGYGLSW 185 V +A + A + ++ + + GE W Sbjct: 53 VTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGE------------PVTATEW 100 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 T W K F H V ++ H + S Sbjct: 101 TGTKVVI-------GTAKGW-----VKVYDAGRESATFQTHAGPVTGLAVHP-GGRILAS 147 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 V D+ + +D + ++ A + +F+P + A G+ + ++ Sbjct: 148 VGVDKSFVFYDLETGERVARGYA----DAALTTCAFHPDG-NLFAAGTQTGHILVFHTTT 202 Query: 306 LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPE 365 L+ I + +S + A+ + ++DL K G + ++ + G Sbjct: 203 LEQAESFPLG--TPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTG--- 257 Query: 366 LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 ++ SW+ ++ +Q++ A +++ Sbjct: 258 ----------EVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEP 294 >5OQL-X nrPDB Length = 630 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 44/344 (12%), Positives = 103/344 (29%), Gaps = 80/344 (23%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDP--------------------- 163 G V P T T + + P P Sbjct: 171 GTVTSVAVCPPYAY---TTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERI 227 Query: 164 -----SGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD 218 D +GH K + + + +++ D + +++ + + Sbjct: 228 CFAKADARKANDKTYQGHLKAPLVVKASQD-GKFVVTGGADKRLVVYNAA-------DLK 279 Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 FT H V +++ + S + D+ + +W S + ++ H E+ Sbjct: 280 PIKAFTQHRDAVTGLAFR-RGTNQLYSCSKDRTVKVW---SLDELAYVETLFGHQDEILD 335 Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLKL----------HSFE------------SH 316 + ++ G+ D+T W + + ++ + +H Sbjct: 336 IDALGQERC-VSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAH 394 Query: 317 KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 + + +V ++ + + + L +W + + A P + + Sbjct: 395 EGSMDRVAM--IDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSAD-E 451 Query: 377 ISDFSWNP-----------NEPW--VICSVSEDNIMQVWQMAEN 407 I D S P P+ +I S S D ++VW+++E+ Sbjct: 452 IPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSED 495 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 40/101 (39%), Gaps = 16/101 (15%) Query: 312 SFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG 371 +++ H V+ S + + + G D+RL V++ + + ++ Sbjct: 241 TYQGHLKAPLVVKASQDGK-FVVTGGADKRLVVYNAADLKPIKA--------------FT 285 Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 H ++ ++ + S S+D ++VW + E Y + Sbjct: 286 QHRDAVTGLAFRR-GTNQLYSCSKDRTVKVWSLDELAYVET 325 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 42/260 (16%), Positives = 80/260 (30%), Gaps = 96/260 (36%) Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192 Q+ + T ++V++ + + P H+ GL++ + Sbjct: 254 ASQDGKFVVTGGADKRLVVYN----------AADLKPIKAFTQHRDAVTGLAF-RRGTNQ 302 Query: 193 LLSASDDHTICLW-------------------DISAVPKEGKVV---------------D 218 L S S D T+ +W DI A+ +E V + Sbjct: 303 LYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEE 362 Query: 219 AKTIFTG------------------------HTAVVEDVSWHLLHESLFGSVADDQKLMI 254 ++ +F G H ++ V+ ++ + +F + +D+ L + Sbjct: 363 SQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA--MIDDDMFVTGSDNGDLAL 420 Query: 255 W------------------------DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 W D ++ PS + L PYS+ I Sbjct: 421 WSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIF- 479 Query: 291 TGSADKTVALWDLRNLKLKL 310 +GS D + +W L K KL Sbjct: 480 SGSWDGCIRVWRLSEDKRKL 499 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 39/123 (31%), Gaps = 32/123 (26%) Query: 118 EIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSK----------------- 160 HEG ++R + + + T + + D+ ++ + Sbjct: 389 PASAAHEGSMDRVAMI--DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLED 446 Query: 161 ------PDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG 214 PDPS P R L P S + S S D I +W +S ++ Sbjct: 447 YSADEIPDPSIIPAPQPR------GITALRTLP-YSDLIFSGSWDGCIRVWRLSEDKRKL 499 Query: 215 KVV 217 + V Sbjct: 500 EAV 502 >3ACP-A nrPDB Length = 417 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 50/305 (16%), Positives = 110/305 (36%), Gaps = 47/305 (15%) Query: 108 FGSVSGKIEI---------EIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHP 158 G+ G I++ EI H E+ + ++ P + + + + + ++ Sbjct: 111 LGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFP-SGEALISSSQDMQLKIWSVKDGS 169 Query: 159 SKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD---------ISA 209 + L GH+ ++ + ++LSAS D TI LW+ + Sbjct: 170 NP----------RTLIGHRATVTDIAII-DRGRNVLSASLDGTIRLWECGTGTTIHTFNR 218 Query: 210 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS-------VADDQKLMIWDTRSNNT 262 V++ +F G + ++S + FG+ + + + S Sbjct: 219 KENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKE- 277 Query: 263 SKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKD-EIF 321 + T N L+ + + + G + +A WDLR+ + + F ++ I Sbjct: 278 -QTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPIN 336 Query: 322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFS 381 V ++ + SSG D + + D+ E + P + P L+ ++S F Sbjct: 337 NVYFA--AGALFVSSGFDTSIKL-DIISDPESERPAIEFETPTFLVSN----DDEVSQFC 389 Query: 382 WNPNE 386 + ++ Sbjct: 390 YVSDD 394 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 57/152 (37%), Gaps = 22/152 (14%) Query: 273 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 332 A+ + G+ + + + D N L+ ++H EI ++++ P E + Sbjct: 93 RADYTAVDTAKLQMRRFILGTTEGDIKVLD-SNFNLQREIDQAHVSEITKLKFFPSGEAL 151 Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 392 + SS D +L +W + ++ GH A ++D + V+ S Sbjct: 152 I-SSSQDMQLKIWSVKDGSNPRTLI--------------GHRATVTDIAIIDRGRNVL-S 195 Query: 393 VSEDNIMQVWQMAENIYN-----DEDPEGSVD 419 S D +++W+ E+P V+ Sbjct: 196 ASLDGTIRLWECGTGTTIHTFNRKENPHDGVN 227 >6E29-D nrPDB Length = 345 Score = 74.5 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 44/300 (14%), Positives = 99/300 (33%), Gaps = 42/300 (14%) Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 G R+ + +A+ V+++D +LRGH K Sbjct: 24 RSGHSTCVRFN-RKGDFLASGRVDGTVVIWDLET----------MGVARKLRGHSKNITS 72 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 LSW+ +LLSA + LWD+ + +V A V H + Sbjct: 73 LSWSR-CGRYLLSACQGWKVILWDLQDGKRYREVRF--------RAPVYGAELHPWNHHQ 123 Query: 243 FGSVADDQKLMIWD-------------------TRSNNTSKPSHSVDAHTAEVNCLSFNP 283 F + + + M+ D T ++ + + + + + Sbjct: 124 FAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTA 183 Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLN 343 + +LA G+ + + D R ++ + I ++ + +L ++ DR + Sbjct: 184 SGDHLLA-GTTKGRLNIIDARTREIIYSEKIA-SGIITTLRLTESGRELLVNA-QDRIIR 240 Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + + + D P E F + + +++ +V S ++ + +W+ Sbjct: 241 TFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWE 300 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 30/134 (22%), Positives = 49/134 (36%), Gaps = 12/134 (8%) Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306 +DD L + NT + H+ C+ FN +F LA+G D TV +WDL + Sbjct: 7 SDDYLLQDYPENITNTIR-----SGHS---TCVRFNRKGDF-LASGRVDGTVVIWDLETM 57 Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 + H I + WS +L S+ ++ +WDL + G+ Sbjct: 58 GVA-RKLRGHSKNITSLSWSRCGRYLL-SACQGWKVILWDL-QDGKRYREVRFRAPVYGA 114 Query: 367 LFIHGGHTAKISDF 380 H + Sbjct: 115 ELHPWNHHQFAAAL 128 Score = 61.7 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 45/142 (31%), Gaps = 16/142 (11%) Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221 E + GH + +N L S D T+ +WD+ + Sbjct: 13 QDYPENITNTIRSGHS---TCVRFNRK-GDFLASGRVDGTVVIWDLETMGV-------AR 61 Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 GH+ + +SW L S K+++WD + + A V Sbjct: 62 KLRGHSKNITSLSWSRCGRYLL-SACQGWKVILWDLQDGKRYREVR----FRAPVYGAEL 116 Query: 282 NPYSEFILATGSADKTVALWDL 303 +P++ A + L D+ Sbjct: 117 HPWNHHQFAAALFEDQPMLVDI 138 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 35/90 (38%), Gaps = 19/90 (21%) Query: 315 SHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374 H V+++ + LAS D + +WDL +G + GH+ Sbjct: 26 GHS---TCVRFNRKGD-FLASGRVDGTVVIWDLETMGVARKL--------------RGHS 67 Query: 375 AKISDFSWNPNEPWVICSVSEDNIMQVWQM 404 I+ SW+ +++ + ++ +W + Sbjct: 68 KNITSLSWSRCGRYLLSACQGWKVI-LWDL 96 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 277 NCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS 336 N ++F+ E++ A+ + + +W+ R + E K+E ++W PH + A Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWE-RGHGSLVRMLEGPKEEQGVIEWHPHRALLAACG 333 Query: 337 GTDRRLNVWDLS 348 R+N+W ++ Sbjct: 334 LETGRINIWSVT 345 Score = 31.7 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 38/100 (38%), Gaps = 15/100 (15%) Query: 114 KIEIEIKINHEGEVNRARY----MPQNPCIIATKTPS-SDVLVFDYTKHPSKPDPSGECN 168 I++ ++ + VNR + +A T + ++ +++ G + Sbjct: 256 TIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWER----------GHGS 305 Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDIS 208 L G ++E + W+P+ + + I +W ++ Sbjct: 306 LVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 >3JZG-A nrPDB Length = 402 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 51/268 (19%), Positives = 88/268 (32%), Gaps = 56/268 (20%) Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 GH L ++P LLS S DH + LW+I +V GH V Sbjct: 149 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD----TLVAIFGGVEGHRDEVLSAD 204 Query: 235 WHLLHESLFGSVADDQKLMIW---------------DTRSNNTSKP----------SHSV 269 + LL E + S D L +W D N T++P + Sbjct: 205 YDLLGEKI-MSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 263 Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV---QWS 326 D H V+C+ + + IL + S + + W ++ + + + + + +S Sbjct: 264 DIHRNYVDCVRW--LGDLIL-SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 320 Query: 327 PHN-----------ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375 + + +LA +L VWDL + H A Sbjct: 321 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK--------AKCTTLTHHKCGA 372 Query: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQ 403 I S++ + +I +D + W Sbjct: 373 AIRQTSFSRDSSILIAVC-DDASIWRWD 399 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 97/299 (32%), Gaps = 64/299 (21%) Query: 98 YDSEKGE-FGGFGSVSGKIEIEIKI---------NHEGEVNRARYMPQNPCIIATKTPSS 147 YDS G I I I H +N ++ P++P ++ + + Sbjct: 115 YDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 174 Query: 148 DVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI 207 + +++ G + GH+ E ++ L ++S DH++ LW I Sbjct: 175 ALRLWNIQTDTLVAIFGG-------VEGHRDEVLSADYD-LLGEKIMSCGMDHSLKLWRI 226 Query: 208 SA-----VPKEGKVVDAKTI---FTG-------------HTAVVEDVSWHLLHESLFGSV 246 ++ KE + F H V+ V W L S Sbjct: 227 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL---GDLILSK 283 Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEF--------------ILATG 292 + + ++ W + + + V L YS+ +LA G Sbjct: 284 SCENAIVCW--KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG 341 Query: 293 SADKTVALWDLR---NLKLKLHSFESHK--DEIFQVQWSPHNETILASSGTDRRLNVWD 346 + + +WDL K K + HK I Q +S + +IL + D + WD Sbjct: 342 NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS-RDSSILIAVCDDASIWRWD 399 Score = 71.4 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 32/217 (14%), Positives = 77/217 (35%), Gaps = 32/217 (14%) Query: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 + + GH + ++ +H +L SV+ D L +W+ +++ V+ H E Sbjct: 140 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 199 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-------------------- 315 V ++ E I+ + D ++ LW + + ++ ES Sbjct: 200 VLSADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFP 258 Query: 316 -------HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 H++ + V+W + IL+ S + W K+ ++ + +L Sbjct: 259 DFSTRDIHRNYVDCVRW--LGDLILSKSCE-NAIVCWKPGKMEDDIDKIKPSESNVTILG 315 Query: 369 IHGGHTAKISDFSWNPNE-PWVICSVSEDNIMQVWQM 404 I ++ + ++ ++ + VW + Sbjct: 316 RFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 352 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 65/149 (43%), Gaps = 28/149 (18%) Query: 272 HTAEVNCLSFNPYS----EFILATGSADKTVALWDLRNLKLKLHSFESHKDE-----IFQ 322 H + + FN +S + AT +++ V L++ + ++ +S+ D + Sbjct: 53 HNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHSQG-EIRLLQSYVDADADENFYT 110 Query: 323 VQW---SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 379 W S + +LA +G+ + + + + + + + GH I++ Sbjct: 111 CAWTYDSNTSHPLLAVAGSRGIIRIINPITM--------------QCIKHYVGHGNAINE 156 Query: 380 FSWNPNEPWVICSVSEDNIMQVWQMAENI 408 ++P +P ++ SVS+D+ +++W + + Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNIQTDT 185 >3DW8-B nrPDB Length = 447 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 58/366 (15%), Positives = 113/366 (30%), Gaps = 76/366 (20%) Query: 124 EGEVNRARYMPQNPCIIATKTPSSDVLVFDY-TKHPSKPDPSGECNPDLRLRGHQKE--- 179 E ++ + ++AT V++F ++ + GE N + H+ E Sbjct: 27 EADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDY 86 Query: 180 ---------GYGLSWNPNLSG-HLLSASDDHTICLWDISA----------VPKEGKVVDA 219 + W P + L +++D TI LW IS ++G+ D Sbjct: 87 LKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDP 146 Query: 220 KTIFT-----------------------GHTAVVEDVSWHLLHESLFGSVADDQKLMIWD 256 T+ T HT + +S + +E+ ADD ++ +W Sbjct: 147 TTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYL--SADDLRINLWH 204 Query: 257 TRSNNTSKPSHSVDAHTAE-----VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 311 + S + E + F+P S S+ T+ L D+R L Sbjct: 205 LEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDR 264 Query: 312 S---------------FESHKDEIFQVQWSPHNETILASSGTDR-RLNVWDLSKIGEEQS 355 F I V++S ++ D + VWDL+ Sbjct: 265 HSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMT---RDYLSVKVWDLNMENRPVE 321 Query: 356 PEDAEDGPPELLFIHGGHTAKI--SDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDED 413 + L + + WN ++ V+ + S +N +++ + Sbjct: 322 TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDS-VVMTGSYNNFFRMFDRNTKRDITLE 380 Query: 414 PEGSVD 419 + Sbjct: 381 ASRENN 386 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 31/146 (21%), Positives = 54/146 (36%), Gaps = 19/146 (13%) Query: 290 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349 A G D W +K + + D I V+++ E +LA+ R+ ++ + Sbjct: 4 AGGGNDIQ---WCFSQVKGAVDDDVAEADIISTVEFNHSGE-LLATGDKGGRVVIFQQEQ 59 Query: 350 IGEEQSPEDAEDGPPELLFIHGGH---------TAKISDFSWNP--NEPWVICSVSEDNI 398 + QS E H KI+ W P N + S + D Sbjct: 60 ENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLS-TNDKT 118 Query: 399 MQVWQMAENIYNDEDPEGSVDPEGQG 424 +++W+++E D+ PEG E G Sbjct: 119 IKLWKISER---DKRPEGYNLKEEDG 141 >6BX3-B nrPDB Length = 412 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 6/106 (5%) Query: 264 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 320 K +H+++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 17 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 74 Query: 321 FQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366 + WSP +L SS D + +WDLSK + + Sbjct: 75 TSIAWSPDGRLLLTSS-RDWSIKLWDLSKPSKPLKEIRFDSPIWGC 119 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 48/264 (18%), Positives = 93/264 (35%), Gaps = 44/264 (16%) Query: 167 CNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGH 226 C P L H + ++W+P+ LL++S D +I LWD+S K K + Sbjct: 61 CVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEIRF------- 112 Query: 227 TAVVEDVSWHLLHESLFGSV------------ADDQKLMIWDTRSNNTSKPSHSVDAHTA 274 + + W L + ++D + S + K S H Sbjct: 113 DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL---LSKSDEKQLSSTPDH-G 168 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRN--LKLKLHSFESHKDEIFQVQWSPHNETI 332 V + + I+ G++ + + + +HS + I + S + E Sbjct: 169 YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGER- 227 Query: 333 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW------NPNE 386 LA + +DR + +++S D E+ EL H + I+ W N Sbjct: 228 LAINCSDRTIRQYEISI--------DDENSAVELTLEHK-YQDVINKLQWNCILFSNNTA 278 Query: 387 PWVICS--VSEDNIMQVWQMAENI 408 +++ S S + + +W+ Sbjct: 279 EYLVASTHGSSAHELYIWETTSGT 302 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 68/213 (31%), Gaps = 41/213 (19%) Query: 124 EGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL 183 G V ++P II T + + + EC L++ L Sbjct: 167 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT-----ECIHSLKIT--SSNIKHL 219 Query: 184 SWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH------L 237 + N ++ S D TI ++IS + V T+ + V+ + W+ Sbjct: 220 IVSQNGERLAINCS-DRTIRQYEISIDDENSAV--ELTLEHKYQDVINKLQWNCILFSNN 276 Query: 238 LHESLFGS--VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295 E L S + +L IW+T S + + ++N Sbjct: 277 TAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDIN------------------ 318 Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 328 WD ++ + + FES ++ V P Sbjct: 319 -----WDFYSMSIVSNGFESGNVYVWSVVIPPK 346 >6CB1-s nrPDB Length = 569 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 85/233 (36%), Gaps = 28/233 (12%) Query: 177 QKEGYGLSWNPNLSGHLLSA---SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 +K LSW+ + ++ S + ++ + +S ++ F ++ D Sbjct: 356 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKH-------LTQSPFKKSKGIIMDA 407 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 +H LF V + + I+D K + ++ + +P + ++A+ S Sbjct: 408 KFHPFKPQLF--VCSQRYVRIYDLSQQILVKKL--LPG-ARWLSKIDIHPRGDNLIAS-S 461 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 DK V DL + H+ + V + + +S+ D ++V Sbjct: 462 FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHV-----FHAT 515 Query: 354 QSPEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + ++ L GH + + D W+P E W+ S DN ++W Sbjct: 516 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 567 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 51/138 (36%), Gaps = 18/138 (13%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 +++ P+ +IA+ + VL D P LR H+K +++ Sbjct: 444 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL---------ASTPYKTLRYHEKAVRSVNF 493 Query: 186 NPNLSGHLLSASDDHTICLW--DISAVPKEGKVVDAKTIFTGH----TAVVEDVSWHLLH 239 + SA+DD TI ++ + + ++ TGH + V D WH Sbjct: 494 H-KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 552 Query: 240 ESLFGSVADDQKLMIWDT 257 LF S D +W T Sbjct: 553 AWLF-SAGADNTARLWTT 569 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 103/317 (32%), Gaps = 43/317 (13%) Query: 120 KINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSG-ECNPDLR---LRG 175 K+ GE R R+ +A + + + + + P P P P G Sbjct: 138 KVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAG 197 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV--VDAKTIFTGHTAVVEDV 233 H+ + LS +P+ L + SDD T+ +W+I + + +D + H +E + Sbjct: 198 HKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH---IECI 253 Query: 234 SWHLLHESLFGSVADDQKLMI-------WDTRSNNTSKPSHSVDAHTAEV---NCLSFN- 282 W+ + +VA + + + +D +N +K T + L N Sbjct: 254 EWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNE 313 Query: 283 -----PYSEFILATGSADKTVALWDLRNLKLKLHSF---ESHKDEIFQVQWSPHNETILA 334 E A + K VA W+ + K S K + ++ W + + Sbjct: 314 NGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVT 373 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + S + I D ++P +P + Sbjct: 374 ------------VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ 421 Query: 395 EDNIMQVWQMAENIYND 411 ++++ +++ I Sbjct: 422 --RYVRIYDLSQQILVK 436 >6C0F-s nrPDB Length = 807 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 85/233 (36%), Gaps = 28/233 (12%) Query: 177 QKEGYGLSWNPNLSGHLLSA---SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 +K LSW+ + ++ S + ++ + +S ++ F ++ D Sbjct: 594 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKH-------LTQSPFKKSKGIIMDA 645 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 +H LF V + + I+D K + ++ + +P + ++A+ S Sbjct: 646 KFHPFKPQLF--VCSQRYVRIYDLSQQILVKKL--LPG-ARWLSKIDIHPRGDNLIAS-S 699 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 DK V DL + H+ + V + + +S+ D ++V Sbjct: 700 FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHV-----FHAT 753 Query: 354 QSPEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + ++ L GH + + D W+P E W+ S DN ++W Sbjct: 754 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 51/138 (36%), Gaps = 18/138 (13%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 +++ P+ +IA+ + VL D P LR H+K +++ Sbjct: 682 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL---------ASTPYKTLRYHEKAVRSVNF 731 Query: 186 NPNLSGHLLSASDDHTICLW--DISAVPKEGKVVDAKTIFTGH----TAVVEDVSWHLLH 239 + SA+DD TI ++ + + ++ TGH + V D WH Sbjct: 732 H-KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 790 Query: 240 ESLFGSVADDQKLMIWDT 257 LF S D +W T Sbjct: 791 AWLF-SAGADNTARLWTT 807 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 103/317 (32%), Gaps = 43/317 (13%) Query: 120 KINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSG-ECNPDLR---LRG 175 K+ GE R R+ +A + + + + + P P P P G Sbjct: 376 KVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAG 435 Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV--VDAKTIFTGHTAVVEDV 233 H+ + LS +P+ L + SDD T+ +W+I + + +D + H +E + Sbjct: 436 HKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH---IECI 491 Query: 234 SWHLLHESLFGSVADDQKLMI-------WDTRSNNTSKPSHSVDAHTAEV---NCLSFN- 282 W+ + +VA + + + +D +N +K T + L N Sbjct: 492 EWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNE 551 Query: 283 -----PYSEFILATGSADKTVALWDLRNLKLKLHSF---ESHKDEIFQVQWSPHNETILA 334 E A + K VA W+ + K S K + ++ W + + Sbjct: 552 NGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVT 611 Query: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 394 + S + I D ++P +P + Sbjct: 612 ------------VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ 659 Query: 395 EDNIMQVWQMAENIYND 411 ++++ +++ I Sbjct: 660 --RYVRIYDLSQQILVK 674 >6EM1-m nrPDB Length = 807 Score = 71.8 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 85/233 (36%), Gaps = 28/233 (12%) Query: 177 QKEGYGLSWNPNLSGHLLSA---SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 +K LSW+ + ++ S + ++ + +S ++ F ++ D Sbjct: 594 KKTVKKLSWHRK-GDYFVTVQPDSGNTSVLIHQVSKH-------LTQSPFKKSKGIIMDA 645 Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293 +H LF V + + I+D K + ++ + +P + ++A+ S Sbjct: 646 KFHPFKPQLF--VCSQRYVRIYDLSQQILVKKL--LPG-ARWLSKIDIHPRGDNLIAS-S 699 Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 DK V DL + H+ + V + + +S+ D ++V Sbjct: 700 FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHV-----FHAT 753 Query: 354 QSPEDAEDGPPELLFIHGGH----TAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + ++ L GH + + D W+P E W+ S DN ++W Sbjct: 754 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 51/138 (36%), Gaps = 18/138 (13%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 +++ P+ +IA+ + VL D P LR H+K +++ Sbjct: 682 WLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL---------ASTPYKTLRYHEKAVRSVNF 731 Query: 186 NPNLSGHLLSASDDHTICLW--DISAVPKEGKVVDAKTIFTGH----TAVVEDVSWHLLH 239 + SA+DD TI ++ + + ++ TGH + V D WH Sbjct: 732 H-KKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 790 Query: 240 ESLFGSVADDQKLMIWDT 257 LF S D +W T Sbjct: 791 AWLF-SAGADNTARLWTT 807 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 56/365 (15%), Positives = 119/365 (32%), Gaps = 49/365 (13%) Query: 73 SDEQNHLVIASVQL-PNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRAR 131 ++E+++ L P + ++ + Y + F K K+ GE R R Sbjct: 333 TNEESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQ-----KYSALRKVPGYGESIRER 387 Query: 132 YMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSG-ECNPDLR---LRGHQKEGYGLSWNP 187 + +A + + + + + P P P P GH+ + LS +P Sbjct: 388 FERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDP 447 Query: 188 NLSGHLLSASDDHTICLWDISAVPKEGKV--VDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 + L + SDD T+ +W+I + + +D + H +E + W+ + + Sbjct: 448 S-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH---IECIEWNPDANNGILA 503 Query: 246 VADDQKLMI-------WDTRSNNTSKPSHSVDAHTAEV---NCLSFN------PYSEFIL 289 VA + + + +D +N +K T + L N E Sbjct: 504 VAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENES 563 Query: 290 ATGSADKTVALWDLRNLKLKLHSF---ESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 A + K VA W+ + K S K + ++ W + + Sbjct: 564 AKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVT------------ 611 Query: 347 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 + S + I D ++P +P + ++++ +++ Sbjct: 612 VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ--RYVRIYDLSQ 669 Query: 407 NIYND 411 I Sbjct: 670 QILVK 674 >2P9P-C nrPDB Length = 372 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 54/340 (15%), Positives = 99/340 (29%), Gaps = 59/340 (17%) Query: 110 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP 169 S + +++ H G+V + P + I T + V+ KP Sbjct: 38 SGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRNAYVWTLKGRTWKP-----TLV 91 Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 229 LR+ + + W PN S I I +E K I + Sbjct: 92 ILRI---NRAARCVRWAPNEK-KFAVGSGSRVI---SICYFEQENDWWVCKHIKKPIRST 144 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIW-----DTRSNNTSKP--------SHSVDAHTA-- 274 V + WH + L + + D K I+ + P ++ ++ Sbjct: 145 VLSLDWHP-NSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCG 203 Query: 275 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334 V+ + F+ +A S D TV L D + K+ + + S + V + + + A Sbjct: 204 WVHGVCFSANGS-RVAWVSHDSTVCLAD-ADKKMAVATLASETLPLLAVTFITESSLVAA 261 Query: 335 SS----------------GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG------ 372 RL+V S + E ++ + Sbjct: 262 GHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGL 321 Query: 373 ---HTAKISDFSWNPNEP---WVICSVSEDNIMQVWQMAE 406 H +S S C+ D M +W + Sbjct: 322 DSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 88/276 (31%), Gaps = 42/276 (15%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 ++ + ++ IA + +V +++ + + L+ H + G+ Sbjct: 9 EPISCHAWN-KDRTQIAICPNNHEVHIYEKS--------GNKWVQVHELKEHNGQVTGVD 59 Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 244 W P+ S +++ D +W + +G+ + V W +E F Sbjct: 60 WAPD-SNRIVTCGTDRNAYVWTL-----KGRTWKPTLVILRINRAARCVRWAP-NEKKFA 112 Query: 245 SVADDQKLMI-WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD- 302 + + + I + + N+ H + V L ++P S +LA GS D ++ Sbjct: 113 VGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSV-LLAAGSCDFKCRIFSA 171 Query: 303 ---------LRNLKLKLHSF-------ESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346 F S + V +S + + A D + + D Sbjct: 172 YIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRV-AWVSHDSTVCLAD 230 Query: 347 ------LSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 ++ + E P A E + GH Sbjct: 231 ADKKMAVATLASETLPLLAVTFITESSLVAAGHDCF 266 Score = 65.2 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 36/204 (17%), Positives = 77/204 (37%), Gaps = 20/204 (9%) Query: 226 HTAVVEDVSWHLLHES--LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283 H+ +VE +S H ++ ++ ++ I++ +S N H + H +V + + P Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYE-KSGNKWVQVHELKEHNGQVTGVDWAP 62 Query: 284 YSEFILATGSADKTVALWDLRN-LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 S I+ T D+ +W L+ V+W+P+ + SG+ R + Sbjct: 63 DSNRIV-TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGS-RVI 120 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 ++ + E+ I + + W+PN ++ + S D +++ Sbjct: 121 SI----------CYFEQENDWWVCKHIKKPIRSTVLSLDWHPN-SVLLAAGSCDFKCRIF 169 Query: 403 QMAENIYND---EDPEGSVDPEGQ 423 + P GS P G+ Sbjct: 170 SAYIKEVEERPAPTPWGSKMPFGE 193 >5OV3-A nrPDB Length = 381 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 34/270 (12%), Positives = 98/270 (36%), Gaps = 32/270 (11%) Query: 139 IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASD 198 ++A ++++D+ + H L W+ + L+SAS Sbjct: 39 LLAVGCNDGRIVIWDFLT----------RGIAKIISAHIHPVCSLCWSRD-GHKLVSAST 87 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR 258 D+ + WD+ + + + + + V +H ++ + + Sbjct: 88 DNIVSQWDVLSGDCDQRFRFP--------SPILKVQYHPRDQNKVLVCPM-KSAPV--ML 136 Query: 259 SNNTSKPSHSVDAHTAEVNCLS-FNPYSEFILATGSADKTVALWDLRNL----KLKLHSF 313 + + SK +++N ++ F+ E+I TG+A + + + ++ + Sbjct: 137 TLSDSKHVVLPVDDDSDLNVVASFDRRGEYIY-TGNAKGKILVLKTDSQDLVASFRVTTG 195 Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 S+ I ++++ L ++ DR + V+D +I + E ++ Sbjct: 196 TSNTTAIKSIEFARKGSCFLINTA-DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTP 254 Query: 374 TAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 K ++ + +++ + + + +W+ Sbjct: 255 WKK---CCFSGDGEYIVAGSARQHALYIWE 281 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 28/78 (35%), Gaps = 15/78 (19%) Query: 330 ETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWV 389 T+LA D R+ +WD G + I H + W+ + + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRG--------------IAKIISAHIHPVCSLCWSRDGHKL 82 Query: 390 ICSVSEDNIMQVWQMAEN 407 + S S DNI+ W + Sbjct: 83 V-SASTDNIVSQWDVLSG 99 >5YZG-2 nrPDB Length = 646 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 87/269 (32%), Gaps = 24/269 (8%) Query: 139 IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASD 198 + AT VL F+ + P S + + +++AS Sbjct: 56 VEATLAKKRKVLEFERVYLDNLPSASMYERSYMHRDVITHVVC------TKTDFIITASH 109 Query: 199 DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR 258 D + W K + ++ F H V+E ++ LF SV DD+ + ++D Sbjct: 110 DGHVKFWK-----KIEEGIEFVKHFRSHLGVIESIAVSSEGA-LFCSVGDDKAMKVFDVV 163 Query: 259 SNNTSKPSHS--VDAHTAEVNCLSFNPYSEFILATGSADKT--VALWDLRNLKLKLHSFE 314 + + + C P S T + ++D R LH F+ Sbjct: 164 NFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFD 219 Query: 315 S-HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 H + Q++ +P + ++ SS + W + + + Sbjct: 220 KLHTSPLTQIRLNPVYKAVV-SSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAK 278 Query: 374 TAKI-SDFSWNPNEPWVICSVSEDNIMQV 401 + ++P+ I ++ D +++ Sbjct: 279 CKAYPTSVCFSPDGKK-IATIGSDRKVRI 306 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 31/89 (34%), Gaps = 15/89 (16%) Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375 H+D I V + + + ++ D + W + G E H Sbjct: 89 HRDVITHVVCTKTD--FIITASHDGHVKFWKKIEEGIEFVKH------------FRSHLG 134 Query: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQM 404 I + + + CSV +D M+V+ + Sbjct: 135 VIESIAVSSEGA-LFCSVGDDKAMKVFDV 162 >4J0X-A nrPDB Length = 451 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 51/311 (16%), Positives = 104/311 (33%), Gaps = 64/311 (20%) Query: 153 DYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 212 Y K +K P+ + + GH E ++ +P+ ++++ D + +W ++ Sbjct: 90 KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLS- 147 Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAH 272 KV+ K V +++ + L+ S A D K+ + N + H Sbjct: 148 PVKVIPTKDR----RGEVLSLAFRKNSDQLYASCA-DFKIRTYSI---NQFSQLEILYGH 199 Query: 273 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-----------------KLKLHSFES 315 V +S + G+ D+T LW + + +K ++ E Sbjct: 200 HDIVEDISALAMERCVTV-GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEG 258 Query: 316 HKDEIF----------------QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 E+ V S ++ + + + +W L+K + A Sbjct: 259 EDGEVKYPDESEAPLFFCEGSIDVV-SMVDDFHFITGSDNGNICLWSLAKKKPIFTERIA 317 Query: 360 EDGPPELLF-IHGGHTAK-----------------ISDFSWNPNEPWVICSVSEDNIMQV 401 PE F G T + I+ P V S S ++V Sbjct: 318 HGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKV 376 Query: 402 WQMAENIYNDE 412 W++++N+ + E Sbjct: 377 WKISDNLRSFE 387 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 82/263 (31%), Gaps = 57/263 (21%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR- 174 ++EI H V + C+ +++ G+ L R Sbjct: 192 QLEILYGHHDIVEDISALAMERCVTV-GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 250 Query: 175 ----GHQKEGYGLSWNPNLSG-------------------HLLSASDDHTICLWDISAVP 211 + E + + P+ S H ++ SD+ ICLW ++ Sbjct: 251 MKENAKEGEDGEVKY-PDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKK- 308 Query: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA 271 K + + I G S++ + S D++L + +P Sbjct: 309 ---KPIFTERIAHGILPEP---SFNDI------SGETDEELRKRQLQGKKLLQPF----- 351 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPH 328 + L PYS + +GS ++ +W + + L K + ++Q Sbjct: 352 ---WITSLYAIPYS-NVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 407 Query: 329 NE------TILASSGTDRRLNVW 345 + ILAS + RL W Sbjct: 408 GKHGKEKFRILASIAKEHRLGRW 430 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 13/95 (13%), Positives = 29/95 (30%), Gaps = 9/95 (9%) Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG--------GHTAKISD 379 + D +L +D++ + G + + GH +I Sbjct: 60 KGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILT 119 Query: 380 FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 + +P+ +V+ + D + VW P Sbjct: 120 VAASPDGKYVV-TGGRDRKLIVWSTESLSPVKVIP 153 >5WLC-SG nrPDB Length = 573 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 51/311 (16%), Positives = 104/311 (33%), Gaps = 64/311 (20%) Query: 153 DYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 212 Y K +K P+ + + GH E ++ +P+ ++++ D + +W ++ Sbjct: 212 KYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPD-GKYVVTGGRDRKLIVWSTESLS- 269 Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAH 272 KV+ K V +++ + L+ S A D K+ + N + H Sbjct: 270 PVKVIPTKDR----RGEVLSLAFRKNSDQLYASCA-DFKIRTYSI---NQFSQLEILYGH 321 Query: 273 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-----------------KLKLHSFES 315 V +S + G+ D+T LW + + +K ++ E Sbjct: 322 HDIVEDISALAMERCVTV-GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEG 380 Query: 316 HKDEIF----------------QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 E+ V S ++ + + + +W L+K + A Sbjct: 381 EDGEVKYPDESEAPLFFCEGSIDVV-SMVDDFHFITGSDNGNICLWSLAKKKPIFTERIA 439 Query: 360 EDGPPELLF-IHGGHTAK-----------------ISDFSWNPNEPWVICSVSEDNIMQV 401 PE F G T + I+ P V S S ++V Sbjct: 440 HGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKV 498 Query: 402 WQMAENIYNDE 412 W++++N+ + E Sbjct: 499 WKISDNLRSFE 509 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 82/263 (31%), Gaps = 57/263 (21%) Query: 116 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLR- 174 ++EI H V + C+ +++ G+ L R Sbjct: 314 QLEILYGHHDIVEDISALAMERCVTV-GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 372 Query: 175 ----GHQKEGYGLSWNPNLSG-------------------HLLSASDDHTICLWDISAVP 211 + E + + P+ S H ++ SD+ ICLW ++ Sbjct: 373 MKENAKEGEDGEVKY-PDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKK- 430 Query: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA 271 K + + I G S++ + S D++L + +P Sbjct: 431 ---KPIFTERIAHGILPEP---SFNDI------SGETDEELRKRQLQGKKLLQPF----- 473 Query: 272 HTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPH 328 + L PYS + +GS ++ +W + + L K + ++Q Sbjct: 474 ---WITSLYAIPYS-NVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 529 Query: 329 NE------TILASSGTDRRLNVW 345 + ILAS + RL W Sbjct: 530 GKHGKEKFRILASIAKEHRLGRW 552 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 13/95 (13%), Positives = 29/95 (30%), Gaps = 9/95 (9%) Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHG--------GHTAKISD 379 + D +L +D++ + G + + GH +I Sbjct: 182 KGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILT 241 Query: 380 FSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 + +P+ +V+ + D + VW P Sbjct: 242 VAASPDGKYVV-TGGRDRKLIVWSTESLSPVKVIP 275 >5CXB-B nrPDB Length = 369 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 76/226 (33%), Gaps = 15/226 (6%) Query: 178 KEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 +SW+ H + S I + K + + + + + S+H Sbjct: 157 STIKAISWHR-RGDHFATVSPSGQRSSVAIHTLSKHLTQIPFRKL----NGLAQTASFHP 211 Query: 238 LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKT 297 L F VA + + +D + K ++ +P + ++ GS DK Sbjct: 212 LRPLFF--VATQRSIRCYDLQKLELVKIVQPG---AKWISSFDVHPGGDNLVV-GSYDKR 265 Query: 298 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPE 357 + DL + H + I V++ + A + D L + E Sbjct: 266 LLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQI--FHGKVPNDQLE 323 Query: 358 DAEDGPPELLFIHGGHTA-KISDFSWNPNEPWVICSVSEDNIMQVW 402 + P ++L H + D W+P EPW + S D ++W Sbjct: 324 NPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCV-SAGADGTARLW 368 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 19/73 (26%), Positives = 33/73 (45%), Gaps = 3/73 (4%) Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 328 H V ++ +P LATG D TV +W+L + + + + V+W P Sbjct: 17 FRGHEGRVRSVAIDPTGV-ALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPT 75 Query: 329 NETIL--ASSGTD 339 +T + A++G D Sbjct: 76 KDTFILAAAAGED 88 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 35/110 (31%), Gaps = 9/110 (8%) Query: 152 FDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW--DISA 209 +D D S +R H + + ++ ASDD ++ ++ + Sbjct: 262 YDKRLLWHDLDLSNRPYKTMRF--HTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPN 319 Query: 210 VPKEGKVVDAKTIFTGHTAV----VEDVSWHLLHESLFGSVADDQKLMIW 255 E + + GH V V D+ WH S D +W Sbjct: 320 DQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREP-WCVSAGADGTARLW 368 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 30/91 (32%), Gaps = 14/91 (15%) Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIH 370 F H+ + V P LA+ G D + VW+L + S + D Sbjct: 15 TIFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTGRQVWSVKLNGD--------- 64 Query: 371 GGHTAKISDFSWNPNEPWVICSVSEDNIMQV 401 ++ W P + I + + + + Sbjct: 65 ----EAVNTVRWRPTKDTFILAAAAGEDIFL 91 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 36/97 (37%), Gaps = 12/97 (12%) Query: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219 KP P+ + RGH+ ++ +P L + DD T+ +W++ + V Sbjct: 7 KPFPTVQ---QTIFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGRQVWSVKLN 62 Query: 220 KTIFTGHTAVVEDVSWHLLHESLF--GSVADDQKLMI 254 V V W ++ + +D LMI Sbjct: 63 G------DEAVNTVRWRPTKDTFILAAAAGEDIFLMI 93 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 34/82 (41%), Gaps = 3/82 (3%) Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278 +TIF GH V V+ +L + DD + +W+ + ++ A VN Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVAL-ATGGDDGTVRVWELLTGRQVWSV-KLNGDEA-VNT 69 Query: 279 LSFNPYSEFILATGSADKTVAL 300 + + P + + +A + + L Sbjct: 70 VRWRPTKDTFILAAAAGEDIFL 91 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 24/54 (44%), Gaps = 1/54 (1%) Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 SP++ + P I GH ++ + +P + + +D ++VW++ Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTG-VALATGGDDGTVRVWELLTGR 54 >5K19-A nrPDB Length = 569 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 38/266 (14%), Positives = 83/266 (31%), Gaps = 49/266 (18%) Query: 177 QKEGYGLSWNPNLSGHLLSASDDHTICLWDIS----AVPKEGKVVDAKTIFTGHT----- 227 + + W P L A + L+++ +++ F HT Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 228 ------------AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 + + ++ V+ D L +++ S S Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDG-KFLACVSQDGFLRVFNFDSVELHGTMKSYFG---G 264 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI--- 332 + C+ ++P ++I+ TG D V +W + ++ + HK + V + P+ ++ Sbjct: 265 LLCVCWSPDGKYIV-TGGEDDLVTVWSFVDCRV-IARGHGHKSWVSVVAFDPYTTSVEEG 322 Query: 333 ----LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388 + S D + DL G +++ S + Sbjct: 323 DPMEFSGSDEDFQ----DLLHFGRDRANSTQSRLSKRNSTDSR-------PVSV----TY 367 Query: 389 VICSVSEDNIMQVWQMAENIYNDEDP 414 SV +D + +W + E+I P Sbjct: 368 RFGSVGQDTQLCLWDLTEDILFPHQP 393 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 55/176 (31%), Gaps = 28/176 (15%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 G + + P + I T V V+ + +C R GH+ ++ Sbjct: 263 GGLLCVCWSP-DGKYIVTGGEDDLVTVWSF----------VDCRVIARGHGHKSWVSVVA 311 Query: 185 WNP------NLSGHLLSASD-DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 ++P S SD D D+ ++ + ++ VS Sbjct: 312 FDPYTTSVEEGDPMEFSGSDEDFQ----DLLHFGRDRANSTQSRLSKRNSTDSRPVSV-- 365 Query: 238 LHESLFGSVADDQKLMIWDTRSNNT--SKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 FGSV D +L +WD + +P HT +N S S T Sbjct: 366 --TYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVT 419 >5WLC-LN nrPDB Length = 776 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 39/294 (13%), Positives = 90/294 (30%), Gaps = 39/294 (13%) Query: 125 GEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLS 184 G + + + V++ D + P G D L + L+ Sbjct: 142 GVIWSISINDSQDKLSVGCD-NGTVVLIDISGGP------GVLEHDTILMRQEARVLTLA 194 Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIF---TGHTAVVEDVSWHLLHES 241 W ++ D I +W + + + +V V + Sbjct: 195 W--KKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPR-TD 251 Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301 S + WD + ++ S AH A+V CL+ + + ++ + G D+ + + Sbjct: 252 QIASGDSTGSIKFWDFQFATLNQ---SFKAHDADVLCLTTDTDNNYVFSAG-VDRKIFQF 307 Query: 302 DLRNLKLKLHSFES-------HKDEIFQV-QWSPHNETILASSGTDRRLNVWDLSKIGEE 353 K + ++ H ++I + + L S G ++ L + L+ Sbjct: 308 SQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNG 367 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407 + P + + SW+ ++ +++W M + Sbjct: 368 NYRKMPTVEPYSKNVLVNKEQRLV--VSWS------------ESTVKIWTMGTD 407 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 38/275 (13%), Positives = 87/275 (31%), Gaps = 37/275 (13%) Query: 150 LVFDYTKHPSKPDPSGECNPDLRLRGHQ--------KEGYGLSWNPNLSGHLLSASD--- 198 ++ + ++ + + R+ H+ L+++ + + L+ SD Sbjct: 8 VLKEKSRSLKIRNKPVKMTSQERMIVHRCRFVDFTPATITSLAFSHKSNINKLTPSDLRL 67 Query: 199 -----DHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES--LFGSVADDQK 251 + I +W+ + V++ G +E + W ++ S+ Sbjct: 68 AIGRSNGNIEIWNPRNNWFQEMVIEG-----GKDRSIEGLCWSNVNGESLRLFSIGGSTV 122 Query: 252 LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL- 310 + WD T P + D ++ + +S N S+ L+ G + TV L D+ L Sbjct: 123 VTEWDL---ATGLPLRNYDCNSGVIWSISIN-DSQDKLSVGCDNGTVVLIDISGGPGVLE 178 Query: 311 --HSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368 + + + W + + +D R+ +W K E + Sbjct: 179 HDTILMRQEARVLTLAWKKDD--FVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKK 236 Query: 369 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403 + + P I S ++ W Sbjct: 237 ESTL----VWSVIYLP-RTDQIASGDSTGSIKFWD 266 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 68/188 (36%), Gaps = 20/188 (10%) Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284 H + + ++ + + + IW+ R NN + + L ++ Sbjct: 52 SHKSNINKLT---PSDLRLAIGRSNGNIEIWNPR-NNWFQEMVIEGGKDRSIEGLCWSNV 107 Query: 285 S--EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342 + L + V WDL L L +++ + I+ + + ++ L+ + + Sbjct: 108 NGESLRLFSIGGSTVVTEWDLATG-LPLRNYDCNSGVIWSISIN-DSQDKLSVGCDNGTV 165 Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + D+S G E I A++ +W ++ +VI S D +++W Sbjct: 166 VLIDIS----------GGPGVLEHDTILMRQEARVLTLAWKKDD-FVIGGCS-DGRIRIW 213 Query: 403 QMAENIYN 410 +N N Sbjct: 214 SAQKNDEN 221 >5MC6-j nrPDB Length = 397 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 107/319 (33%), Gaps = 42/319 (13%) Query: 122 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG--HQKE 179 H+ ++ + + + V+D ++ + + G H Sbjct: 14 AHDADIFSVSAC---NSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGH---TAVVEDVSWH 236 + + + + S + + I+ + KV+ K + W Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 237 LLHESLFG--SVADD--QKLMIWDT-----RSNNTS---KPSHSVDAH-------TAEVN 277 ++ L VA D IW SN+ + P+ + + Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 278 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFE------SHKDEIFQVQWSPHNET 331 + + ++ATG + TV + +L L+ L++FE ++ + I V++SP + Sbjct: 191 SVDISERG--LIATGFNNGTVQISELSTLR-PLYNFESQHSMINNSNSIRSVKFSPQG-S 246 Query: 332 ILASSGTDRR---LNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388 +LA + + +++ ++ GE + H++ + S+N + Sbjct: 247 LLAIAHDSNSFGCITLYE-TEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DSGE 304 Query: 389 VICSVSEDNIMQVWQMAEN 407 +CS D ++ W + Sbjct: 305 TLCSAGWDGKLRFWDVKTK 323 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 103/309 (33%), Gaps = 57/309 (18%) Query: 86 LPNDDAQFDA-SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKT 144 L N++ + + SH+ + G +++ I + C++AT + Sbjct: 46 LDNENPKDKSYSHFVHKSGLH--------HVDVLQAIERDA---------FELCLVATTS 88 Query: 145 PSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLS---ASDD-- 199 S D+L + T+ E L + + L W + LLS + D Sbjct: 89 FSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW-GASNDRLLSHRLVATDVK 147 Query: 200 HTICLWDISAVPKEGKV----VDAKTIFTG-----HTAVVEDVSWHLLHESLFGSVADDQ 250 T +W E G T S + L + ++ Sbjct: 148 GTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNG 207 Query: 251 KLMIWDTRSNNTSKPSHSVDAH------TAEVNCLSFNPYSEFILATGSAD--KTVALWD 302 + I + +T +P ++ ++ + + + F+P + ++ + L++ Sbjct: 208 TVQISEL---STLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYE 264 Query: 303 ------LRNLKLKLHSFES------HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 + +L + HS ++ H + + ++ ET L S+G D +L WD+ Sbjct: 265 TEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGET-LCSAGWDGKLRFWDVKTK 323 Query: 351 GEEQSPEDA 359 + Sbjct: 324 ERITTLNMH 332 >5TF2-A nrPDB Length = 407 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 39/242 (16%), Positives = 76/242 (31%), Gaps = 39/242 (16%) Query: 126 EVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSW 185 + + + ++AT V V+ L + H+ E L+ Sbjct: 173 PLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEK----------VLEFKAHEGEIEDLAL 222 Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW-----HLLHE 240 P+ G L++ D +W + + + F+ + + Sbjct: 223 GPD--GKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGL 280 Query: 241 SLFGSVADDQKLM--------IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 LF ++L WD + P + V+CL + S L G Sbjct: 281 RLFTVQIPHKRLRQPPPCYLTAWD---GSNFLPLRTKSCGHEVVSCLDVS-ESGTFLGLG 336 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP----------HNETILASSGTDRRL 342 + +VA++ +L+ + E+H + V + P +ET L S D R Sbjct: 337 TVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRC 396 Query: 343 NV 344 + Sbjct: 397 QL 398 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 32/232 (13%), Positives = 67/232 (28%), Gaps = 49/232 (21%) Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 + +N + + L + D + +W + ++ K + F H +ED++ + Sbjct: 178 VCFN-HDNTLLATGGTDGYVRVWKVPSLEKVLE-------FKAHEGEIEDLALGPDGK-- 227 Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 +V D K +W V L + +T + Sbjct: 228 LVTVGRDLKASVWQK---------------DQLVTQLHWQENGPTFSSTPYRYQACRFGQ 272 Query: 303 LRNLKLKLHSFES---HKD-----EIFQVQWSPHNETIL---ASSGTDRRLNVWDLSKIG 351 + + L F HK + W L S ++ D+S+ G Sbjct: 273 VPDQPAGLRLFTVQIPHKRLRQPPPCYLTAW--DGSNFLPLRTKSCGHEVVSCLDVSESG 330 Query: 352 EEQSPEDAEDGP--------PELLFIHGGHTAKISDFSWNPN---EPWVICS 392 L ++ H ++D ++ P P ++ S Sbjct: 331 TFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGS 382 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 37/93 (39%), Gaps = 16/93 (17%) Query: 317 KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 D + +V H+ T+LA+ GTD + VW + + E + H + Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL--------------EKVLEFKAHEGE 216 Query: 377 ISDFSWNPNEPWVICSVSEDNIMQVWQMAENIY 409 I D + P+ + +V D VWQ + + Sbjct: 217 IEDLALGPDGK--LVTVGRDLKASVWQKDQLVT 247 >6CHG-D nrPDB Length = 439 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 86/270 (31%), Gaps = 36/270 (13%) Query: 161 PDPSGECNPDLRLRGHQKEG----YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV 216 DP G H E + ++P + S+ I ++D+ ++ K Sbjct: 7 QDPFGVLKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSN-GAIIIYDMDSL----KP 61 Query: 217 VDAKTIFTG-HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275 + +G HT V+ V W L+ S D +WD + D Sbjct: 62 IAMLGTHSGAHTRSVQSVCWSNDGRYLWSSG-RDWYAKLWDMTQPTKCFQQYKFDGPLWS 120 Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF---------ESHKDEIFQVQWS 326 + + +N + T + T + L + + H F H Sbjct: 121 CHVVRWNVC----IVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGH-GYTLVACPH 175 Query: 327 PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386 P E+I+ + + +N + L E + + A I +P+ Sbjct: 176 PTIESIIITGTSKGWINAFQL-------DLESGFEDKIRCCYEEKIANANIKQIIISPSG 228 Query: 387 PWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 + + S D ++ +Q+ I D + EG Sbjct: 229 TRIAINGS-DRTIRQYQL---IVEDNESEG 254 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 69/202 (34%), Gaps = 19/202 (9%) Query: 114 KIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL 173 +E + I+ G A P II T T + F D C + Sbjct: 156 LLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIA 215 Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI--SAVPKEGKVVDAKTIFTGH--TAV 229 + +P+ + ++ S D TI + + EG + +I H + Sbjct: 216 ---NANIKQIIISPSGTRIAINGS-DRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDI 271 Query: 230 VEDVSWHL------LHESLFGS--VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 281 + + W+ E L S + L +W+T S + + ++ E+ + + Sbjct: 272 INRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVR---VLEGADEELLDIDW 328 Query: 282 NPYSEFILATGSADKTVALWDL 303 N YS I + G V +W + Sbjct: 329 NFYSMRIASNGFESGWVYMWSI 350 >3DWL-C nrPDB Length = 377 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 62/201 (30%), Gaps = 25/201 (12%) Query: 161 PDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK 220 H K + W P S +++ S D +++ + Sbjct: 39 EQDGNGWKHARTFSDHDKIVTCVDWAPK-SNRIVTCSQDRNAYVYE----KRPDGTWKQT 93 Query: 221 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMI-WDTRSNNTSKPSHSVDAHTAEVNCL 279 + V W +E F + + + + + + N+ H + + L Sbjct: 94 LVLLRLNRAATFVRWSP-NEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSL 152 Query: 280 SFNPYSEFILATGSADKTVALWDLR-------------NLKLKLHSFESH---KDEIFQV 323 ++P + +LA G AD+ + +L ++ + + V Sbjct: 153 DWHPNNV-LLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAV 211 Query: 324 QWSPHNETILASSGTDRRLNV 344 +SP LA +G D + + Sbjct: 212 GFSPSG-NALAYAGHDSSVTI 231 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/178 (18%), Positives = 63/178 (35%), Gaps = 17/178 (9%) Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302 F + ++ +++ + N K + + H V C+ + P S I+ T S D+ +++ Sbjct: 26 FVTTTATNQVELYE-QDGNGWKHARTFSDHDKIVTCVDWAPKSNRIV-TCSQDRNAYVYE 83 Query: 303 LR--NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 R + V+WSP+ + SG R ++V + E Sbjct: 84 KRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGA-RVISV----------CYFEQE 132 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 + + + I W+PN ++ + D V D PE SV Sbjct: 133 NDWWVSKHLKRPLRSTILSLDWHPNN-VLLAAGCADRKAYVLSAY-VRDVDAKPEASV 188 >5WLC-LW nrPDB Length = 554 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 64/182 (35%), Gaps = 24/182 (13%) Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + + H L + + L D + + ++ NP++ ++ G Sbjct: 196 LDFLPYH-YLLVTAGETGWLKYHDVSTGQLVSELRTKAG---PTMAMAQNPWNA-VMHLG 250 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 ++ TV+LW ++ L S + + + +A++G DR + +WD+ + Sbjct: 251 HSNGTVSLWS-PSMPEPLVKLLSARGPVNSIAIDRSG-YYMATTGADRSMKIWDIRNFKQ 308 Query: 353 EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDE 412 S E ++ S + + ++S + +W+ A + D Sbjct: 309 LHSVESLPTPG--------------TNVSISDTG---LLALSRGPHVTLWKDALKLSGDS 351 Query: 413 DP 414 P Sbjct: 352 KP 353 >3JB9-S nrPDB Length = 488 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 81/234 (34%), Gaps = 41/234 (17%) Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 +P S +L D +CL + + IF G ++ L S Sbjct: 218 SPENSSFVLCLHKDELLCL--------DIQSNSTLKIFEG-----SALACCWLTSSKIAV 264 Query: 246 VADDQKLMIWDTRSNNTS-----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 D + I++ +++ +P+ S+ VN L +P E++LA + + Sbjct: 265 ATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEK-VNFLQAHPSGEYLLAASNE--KCYI 320 Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + L++ + + H I + P +A E E Sbjct: 321 FSLKSQVYNI-TVAQH---ITSLAVHPDGNLFVAG---------------LENGELRFFE 361 Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDP 414 L G H++ + + N W++ + ++D+ + +W + ++ + P Sbjct: 362 TSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIP 415 Score = 35.9 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 24/156 (15%), Positives = 53/156 (33%), Gaps = 11/156 (7%) Query: 145 PSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICL 204 P ++ V + + N + H L + N +++ +DD I + Sbjct: 343 PDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFI 402 Query: 205 WDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK 264 WD+ K+ V VS + + L S + + I+ +S+ + + Sbjct: 403 WDLRKSELVQKIPLQTK--------VAAVSLDITSQLLVSSDGETLYVHIY-VKSSKSWR 453 Query: 265 PSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300 H + ++ L + +L + S + L Sbjct: 454 CMSQT--HVSSISNLVWLNELHQLLFSTSNGAILRL 487 >6CVZ-A nrPDB Length = 351 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 26/107 (24%), Positives = 43/107 (40%), Gaps = 10/107 (9%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H K+ GL+++ L G LLSAS D+TI L + + V W Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGR--------PVWSCCW 124 Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 L + + + ++++D R NTS + A A +S + Sbjct: 125 CLDEANYIYAGLANGSILVYDVR--NTSSHVQELVAQKARCPLVSLS 169 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 14/101 (13%), Positives = 35/101 (34%), Gaps = 4/101 (3%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285 H + +++ L S + D + + +N + ++ V + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA----GRPVWSCCWCLDE 128 Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWS 326 + G A+ ++ ++D+RN + + K V S Sbjct: 129 ANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 169 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 51/140 (36%), Gaps = 6/140 (4%) Query: 257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESH 316 S K S + H ++ L+F+ Y +L + S D T+ L L + + ++ + Sbjct: 58 MLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTV-VQTYNAG 116 Query: 317 KDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAK 376 + ++ W + + + + V+D+ A+ L+ + A Sbjct: 117 R-PVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAA 175 Query: 377 ISDFSWNPNEPWVICSVSED 396 + F + V+ ED Sbjct: 176 SAAFPY----GGVLAGTLED 191 Score = 35.2 bits (79), Expect = 0.053, Method: Composition-based stats. Identities = 8/44 (18%), Positives = 18/44 (40%) Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEG 416 H +I +++ ++ S S DN +++ + N G Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAG 116 >4FHN-A nrPDB Length = 394 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 92/273 (33%), Gaps = 44/273 (16%) Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235 H +G ++ +P S L D+T+ L I + +GH V D+ Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRL--IITKNETIITQHVLGGKSGHHNFVNDIDI 145 Query: 236 -------HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288 + L E + SV DD L+IW R + P + ++ + F P + Sbjct: 146 ADVYSADNRLAEQVIASVGDDCTLIIW--RLTDEG-PILAGYPLSSPGISVQFRPSNPNQ 202 Query: 289 LATGSADKTVALWDL---------------RNLKLK-LHSF----ESHKDEIFQ----VQ 324 L G + + ++D +N L L++ H I V+ Sbjct: 203 LIVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVR 262 Query: 325 WS-PHNETILASSGTDRRLNVWDL--SKIGEEQSPEDAEDGPPELLFIHGGHT--AKISD 379 W ILA + L W+L + E S + GP LL G + + Sbjct: 263 WIGSDGSGILAMCKSGAWLR-WNLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLG 321 Query: 380 FSWNPNEPWVICSV-SEDNIMQVWQMAENIYND 411 +P + S+ ++Q+ E N Sbjct: 322 ACPHPRYMDYFATAHSQHGLIQLINTYEKDSNS 354 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 23/151 (15%), Positives = 50/151 (33%), Gaps = 25/151 (16%) Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF----ESHKDEIFQVQ----WSPHNE 330 ++ +P LA D TV L +N + H + + + +S N Sbjct: 95 VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNR 154 Query: 331 ---TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 387 ++AS G D L +W L+ G + + P+ P Sbjct: 155 LAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGI--------------SVQFRPSNP 200 Query: 388 WVICSVSEDNIMQVWQMAENIYNDEDPEGSV 418 + + ++++ N+ +E+ + + Sbjct: 201 NQLIVGERNGNIRIFDWTLNLSAEENSQTEL 231 Score = 33.2 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 10/70 (14%), Positives = 25/70 (35%), Gaps = 10/70 (14%) Query: 139 IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASD 198 +IA+ ++++ T P +G G + + P+ L+ Sbjct: 159 VIASVGDDCTLIIWRLT--DEGPILAGYPL--------SSPGISVQFRPSNPNQLIVGER 208 Query: 199 DHTICLWDIS 208 + I ++D + Sbjct: 209 NGNIRIFDWT 218 Score = 28.2 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 20/202 (9%), Positives = 56/202 (27%), Gaps = 30/202 (14%) Query: 117 IEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPS-GECNPDLRL-- 173 I ++ P NP + + ++ +FD+T + S + S E + L Sbjct: 180 ILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLT 239 Query: 174 --------RGHQKEGYG----LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221 H + W + +L+ W++ A ++ D+ Sbjct: 240 LNTLPLVNTCHSSGIASSLANVRWIGSDGSGILAMCKSGAWLRWNLFANNDYNEISDSTM 299 Query: 222 IF---------TGHTAVVEDVSWHLLHESL--FGSV-ADDQKLMIWDTRSNNTSKPSHSV 269 G + + + F + + + + +T +++ + Sbjct: 300 KLGPKNLLPNVQGISLFPSLLGACPHPRYMDYFATAHSQHGLIQLINTYEKDSNSIPIQL 359 Query: 270 DAHTAEVNCLSFNPYSEFILAT 291 + ++ + Sbjct: 360 ---GMPIVDFCWHQDGSHLAIA 378 >2VDU-B nrPDB Length = 450 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 26/198 (13%), Positives = 62/198 (31%), Gaps = 13/198 (6%) Query: 178 KEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHL 237 L + S + A D ++ ++D+ K + + F + +S Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCF---SKRPNAISIAE 159 Query: 238 LHESLFGSVADDQKLMIW--DTRSNNTSKPSHS-VDAHTAEVNCLSF--NPYSEFILATG 292 ++ + D+ ++ D S K + + H + + + + + T Sbjct: 160 DDTTVIIA---DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS 216 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 D+ + + + HK + + +L S+G D ++ WD Sbjct: 217 DRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKD--YLLLSAGGDDKIFAWDWKTGKN 274 Query: 353 EQSPEDAEDGPPELLFIH 370 + + P L H Sbjct: 275 LSTFDYNSLIKPYLNDQH 292 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 25/87 (28%), Gaps = 2/87 (2%) Query: 124 EGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL 183 + + M + +I ++ D +H D L GH+ + Sbjct: 188 QEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSI 247 Query: 184 SWNPNLSGHLLSASDDHTICLWDISAV 210 LLSA D I WD Sbjct: 248 --CCGKDYLLLSAGGDDKIFAWDWKTG 272 >5WLC-LV nrPDB Length = 707 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 35/200 (17%), Positives = 72/200 (36%), Gaps = 21/200 (10%) Query: 213 EGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSH---SV 269 + F T V VS + ++ L + + + WD RS + + ++ Sbjct: 166 NLEKGRFLNPFKLDTEGVNHVSINEVN-GLLAAGTETNVVEFWDPRSRSRVSKLYLENNI 224 Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 329 D +V SF A G+++ ++DLR + + + + +I ++ W + Sbjct: 225 DNRPFQVTTTSFRNDG-LTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNV 283 Query: 330 E--TILASSGTDRRL-NVWD------LSKIGEEQSPEDAEDGPPELLFIHG-----GHTA 375 + + D+R+ +WD + + D E P +F HT Sbjct: 284 GTENKIVTC--DKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFFTANESIPMHTY 341 Query: 376 KISDFSWNPNEPWVICSVSE 395 I +P + S++E Sbjct: 342 YIPSLGPSPRWCSFLDSITE 361 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 58/185 (31%), Gaps = 45/185 (24%) Query: 256 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 D N + + A N + + ++ +ATG+ + ++D NL LK F+ Sbjct: 40 DLEYQNRVELIQDFEFSEAS-NKIKVSRDGQYCMATGTYKPQIHVYDFANLSLK---FDR 95 Query: 316 HKDE------IFQVQWSPHNETILASSGTDRRL--------------------NVWD--- 346 H D I W+ DR + V++ Sbjct: 96 HTDAENVDFTILSDDWTKSVHLQ-----NDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVN 150 Query: 347 ----LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 + G E + E G F T ++ S N ++ + +E N+++ W Sbjct: 151 CDLYVGASGNELYRLNLEKGRFLNPFKLD--TEGVNHVSIN-EVNGLLAAGTETNVVEFW 207 Query: 403 QMAEN 407 Sbjct: 208 DPRSR 212 >5LTD-A nrPDB Length = 525 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 53/114 (46%), Gaps = 7/114 (6%) Query: 248 DDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV-ALWDLRNL 306 + ++I+D + T +P+ ++AH + ++ + +LAT S T+ ++ + Sbjct: 200 RNGDVIIFDAK---TLQPTSVIEAHRTSLAAIALSKDG-LLLATASDKGTIIRVFSVATG 255 Query: 307 KLKLHSFES-HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359 + +I+ + +SP N ++ASS T ++++ L + + + A Sbjct: 256 IKLYQFRRGTYPTKIYSLAFSPDNRFVIASSAT-ETVHIFRLGEEEAANTIKSA 308 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 44/113 (38%), Gaps = 14/113 (12%) Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353 + V ++D + L+ E+H+ + + S +LA++ + Sbjct: 200 RNGDVIIFDAKTLQ-PTSVIEAHRTSLAAIALSKDG-LLLATASDKGTI----------- 246 Query: 354 QSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406 G F G + KI +++P+ +VI S + + + ++++ E Sbjct: 247 IRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATE-TVHIFRLGE 298 Score = 31.3 bits (69), Expect = 0.77, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 51/144 (35%), Gaps = 12/144 (8%) Query: 67 VLGTHTSDEQNHLVIASVQLPNDDAQFDAS-HYDSEKGEFGGFGSVSGK-IEIEIKINHE 124 ++ S E N+L S Q + Q + + H + + G K ++ I Sbjct: 162 LIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAH 221 Query: 125 GEVNRARYMPQNPCIIATKTPSSDVL-VFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL 183 A + ++ ++AT + ++ VF P + Y L Sbjct: 222 RTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPT--------KIYSL 273 Query: 184 SWNPNLSGHLLSASDDHTICLWDI 207 +++P+ + S S T+ ++ + Sbjct: 274 AFSPDNRFVIAS-SATETVHIFRL 296 >5WLC-LS nrPDB Length = 594 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 63/158 (39%), Gaps = 12/158 (7%) Query: 198 DDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL-FGSVADDQKLMIWD 256 + H I W + G + + G T + + ++ ++ + ++D Sbjct: 440 NGHVIRRWK----DQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYD 495 Query: 257 ---TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI-LATGSADKTVALWDLRNLKLKLHS 312 +++T P ++D T ++ L F+P + + +A+ + + L L + + + Sbjct: 496 RNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNW 555 Query: 313 FESHK--DEIFQVQWSPHNETILASSGTDRRLNVWDLS 348 S ++ V +SP +LA ++ +W L+ Sbjct: 556 PTSGTPLGKVTSVAFSPSGG-LLAVGNEQGKVRLWKLN 592 Score = 34.4 bits (77), Expect = 0.085, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 37/113 (32%), Gaps = 11/113 (9%) Query: 302 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 361 D+ LK S SH I + + P + +L + G D+ L ++ + Sbjct: 234 DIVRLKDANASHPSHS-AIQSLSFHPS-KPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLV 291 Query: 362 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA-ENIYNDED 413 G P S + I + M W ++ EN+ + + Sbjct: 292 GSPIQTCTFYT--------SLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQT 336 Score = 34.4 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 39/92 (42%), Gaps = 5/92 (5%) Query: 215 KVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW--DTRSNNTSKPSHSVDAH 272 ++ DA H+A ++ +S+H L + D+ L I+ D ++N+ H V + Sbjct: 237 RLKDANASHPSHSA-IQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSP 294 Query: 273 TAEVNCL-SFNPYSEFILATGSADKTVALWDL 303 S + ++ + T + + WDL Sbjct: 295 IQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDL 326 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 50/116 (43%), Gaps = 13/116 (11%) Query: 271 AHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKLHSFESHKDEIFQVQW--- 325 +H+A + LSF+P +L TG DKT+ ++ D + L + S I + Sbjct: 247 SHSA-IQSLSFHPSKPLLL-TGGYDKTLRIYHIDGKTNHL-VTSLHLVGSPIQTCTFYTS 303 Query: 326 -SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 380 S N+ + ++G R ++ WDLS ++ ++ E GH + F Sbjct: 304 LSNQNQQNIFTAGRRRYMHSWDLS----LENLTHSQTAKIEKFSRLYGHESTQRSF 355 >2I3T-A nrPDB Length = 341 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 35/259 (13%), Positives = 90/259 (34%), Gaps = 33/259 (12%) Query: 114 KIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRL 173 +++ + ++ + ++ I T ++L D PS + Sbjct: 46 NVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNN------- 98 Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233 + L++AS D I ++ G V A + V++ Sbjct: 99 ---EANLGICRICKYGDDKLIAASWDGLI---EVIDPRNYGDGVIAVKNLNSNNTKVKNK 152 Query: 234 SWH-LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD--AHTAEVNCLSFNPYSEFILA 290 + + S ++ ++ W R + +++ ++ ++ P + A Sbjct: 153 IFTMDTNSSRLIVGMNNSQVQ-W-FRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYA 210 Query: 291 TGSADKTVAL--WDLRN---LKLKLHSFESHK---------DEIFQVQWSPHNETILASS 336 S D VA+ +D + K +F H+ + +++SP ++ L ++ Sbjct: 211 CSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHK-FLYTA 269 Query: 337 GTDRRLNVWDLSKIGEEQS 355 G+D ++ W+L + ++ Sbjct: 270 GSDGIISCWNLQTRKKIKN 288 >5WLC-LH nrPDB Length = 896 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 55/134 (41%), Gaps = 4/134 (2%) Query: 239 HESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTV 298 H+S+ D + + + S + S+ +T V+ ++ + + LA G A + Sbjct: 222 HKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQ-LAVGFASGVI 280 Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358 ++ L + L++ + H D + + +S +L S G ++ +++W L ++ P Sbjct: 281 SIVSLAD--LQIRLLKWHIDSVLSLSFSHDGSYLL-SGGWEKVMSLWQLETNSQQFLPRL 337 Query: 359 AEDGPPELLFIHGG 372 + G Sbjct: 338 NGIIIDCQVLGPQG 351 Score = 36.7 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 38/271 (14%), Positives = 90/271 (33%), Gaps = 26/271 (9%) Query: 170 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 229 L+ H LS++ + +LLS + + LW + ++ G Sbjct: 290 IRLLKWHIDSVLSLSFS-HDGSYLLSGGWEKVMSLWQLETNSQQ-----FLPRLNGIIID 343 Query: 230 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAH-TAEVNCLSFNPYSEFI 288 + + + SL + ++ + N S + + + V + + I Sbjct: 344 CQVLGPQGNYYSLILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPI 403 Query: 289 LATGSAD-KTVALWDLRNLKLKLHSFESHK-DEIFQVQWSPHNETILASSGTDRRLNVWD 346 A + + ++ + K +S + D V+ +P N+ + + ++D Sbjct: 404 SAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYF--PHISAVQIFD 461 Query: 347 LSKIGE---EQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC----------SV 393 K + + + ++ F I+D + + W+I Sbjct: 462 FYKNEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLS 521 Query: 394 SED--NIMQVWQMAENIYNDEDPEGSVDPEG 422 S+D +I++ W +N N ++P G Sbjct: 522 SKDLTHILKFWTKNDNETNWNLKTKVINPHG 552 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 30/199 (15%), Positives = 67/199 (33%), Gaps = 26/199 (13%) Query: 74 DEQNHLVIASVQLPNDDA-------QFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126 E N+ ++ + + P+ A + A +D K +F I I+ G+ Sbjct: 147 SEGNYRILTTFKDPSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGK 206 Query: 127 VNRARYMPQNPCIIATKTPSSD----VLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182 + ++TK V +FD + + S P S + L + + Sbjct: 207 LLAHMCKD-----VSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSS 261 Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242 ++ + N+ L I + ++ + + H V +S+ S Sbjct: 262 MAID-NMGQQLAVGFASGVISIVSLADLQ--------IRLLKWHIDSVLSLSFS-HDGSY 311 Query: 243 FGSVADDQKLMIWDTRSNN 261 S ++ + +W +N+ Sbjct: 312 LLSGGWEKVMSLWQLETNS 330 >6IYY-A nrPDB Length = 317 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 28/206 (13%), Positives = 63/206 (30%), Gaps = 25/206 (12%) Query: 196 ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW 255 + +WD K+ V++ + + V+ V + D + ++ Sbjct: 67 GGGKKKVMIWD---DLKKKTVIEIEF-----STEVKAVKLRRDRIVVVL----DSMIKVF 114 Query: 256 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 315 N + + L N + + G+ V L DL + + + Sbjct: 115 TFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPA 174 Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375 H+ + + + I +S + ++D S Q G A Sbjct: 175 HEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELR------------RGSQAA 222 Query: 376 KISDFSWNPNEPWVICSVSEDNIMQV 401 I ++N + +IC S+ + + Sbjct: 223 NIYCINFNQDAS-LICVSSDHGTVHI 247 >5K1H-B nrPDB Length = 576 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 251 KLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG--SADKTVALWDLRNLKL 308 + + +SN + S D + N + ++P +F++ G S + +A D Sbjct: 419 SVSFYHVKSNGKIELSKMFD--KQQANTIFWSPQGQFVVLAGLRSMNGALAFVD--TSDC 474 Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGT-----DRRLNVW 345 + + H V+W P ++ S D +W Sbjct: 475 TVMNIAEHYMA-SDVEWDPTGRYVVTSVSWWSHKVDNAYWLW 515 Score = 29.0 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 49/136 (36%), Gaps = 21/136 (15%) Query: 280 SFNPYSE-FILATGSADK-TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 337 ++ P F + G A + +V+ + +++ S K + + WSP + ++ + Sbjct: 400 AWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQGQFVVLAG- 458 Query: 338 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE-- 395 L + + D D + H + D W+P +V+ SVS Sbjct: 459 ---------LRSMNGALAFVDTSDCTVMNIAEHYMAS----DVEWDPTGRYVVTSVSWWS 505 Query: 396 ---DNIMQVWQMAENI 408 DN +W + Sbjct: 506 HKVDNAYWLWTFQGRL 521 >5AMS-A nrPDB Length = 431 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 44/146 (30%), Gaps = 14/146 (9%) Query: 269 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH-SFESHKDEIFQVQWSP 327 D HT V + +P ++ TG D LW + K + + + + ++ Sbjct: 61 FDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 387 L ++ ++ V + G L +I +P Sbjct: 120 EGG-FLVTADMSGKVLVH-----------MGQKGGAQWKLASQMQEVEEIVWLKTHPTIA 167 Query: 388 WVICSVSEDNIMQVWQMAENIYNDED 413 + D + +Q+ E + E Sbjct: 168 RTFAFGATDGSVWCYQINEQDGSLEQ 193 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 36/266 (13%), Positives = 89/266 (33%), Gaps = 37/266 (13%) Query: 126 EVNRARYMPQNPCIIAT---KTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG--HQKEG 180 EV ++ +P I T V + + + + G HQ++ Sbjct: 153 EVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLE--------QLMSGFVHQQDC 204 Query: 181 YGLSW-NPNLSGH---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 236 + N + + L++ S D TI W+ + K+ + G A +S Sbjct: 205 SMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKI--TQAEIKGLEAPWISLSLA 262 Query: 237 LL-----HESLFGSVADDQKLMIWDTRSNNTSKPSHSV-------DAHTAEVNCLSFNPY 284 + + +++ L + + + +V D A + +S++ Sbjct: 263 PETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSK 322 Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344 ++A G + L+D ++ +D + ++ + N+ + AS ++ Sbjct: 323 FS-LMAIGLVCGEILLYD--TSAWRVRHKFVLEDSVTKLMF--DNDDLFASCIN-GKVYQ 376 Query: 345 WDLSKIGEEQSPEDAEDGPPELLFIH 370 ++ E+ G + + +H Sbjct: 377 FNARTGQEKFVCVGHNMGVLDFILLH 402 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 17/42 (40%), Gaps = 1/42 (2%) Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402 D L HT + +PN P V C+ DN+ +W Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLV-CTGGGDNLAHLW 92 >6NAU-A nrPDB Length = 334 Score = 35.9 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 98/313 (31%), Gaps = 45/313 (14%) Query: 111 VSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPD 170 GK+ + ++ G+V P + P VL + T +GE Sbjct: 25 ADGKLTLVQVVDAPGQVQPMVVSPNKEFLYVGVRPEFRVLAYRITPDNGALTFAGEA--- 81 Query: 171 LRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTG-HTA 228 G + + G + SAS + G+ + G H+A Sbjct: 82 ------ALPGSPTHISTDRHGRFVFSASYNQGCVSVTPLHDGLPGETITVVEGLEGCHSA 135 Query: 229 VV---EDVSWHL---LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282 + W +++DD L + +P+ A + F+ Sbjct: 136 NISPDNRTLWVPALKQDRICLFTLSDDGFL--------SAQEPAEVTTVEGAGPRHMVFH 187 Query: 283 PYSEFILATGSADKTVALWDLRNLK---LKLHSFE------SHKDEIFQVQWSPHNETIL 333 P ++ + ++ +W+L++ K + + + S + +P + Sbjct: 188 PNQQYGYCVNELNSSIDVWELKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDGRHLY 247 Query: 334 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV 393 A T + V+ +S+ G + E + + + H+ ++I + Sbjct: 248 ACDRTASIITVFSVSEDGSVLAVEGYQPTETQPRGFNLDHS-----------GKYLIAAG 296 Query: 394 SEDNIMQVWQMAE 406 + + + V+ + Sbjct: 297 QKSHHIAVYDIVG 309 Score = 29.8 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 37/223 (16%), Positives = 79/223 (35%), Gaps = 15/223 (6%) Query: 195 SAS-DDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253 +AS + I +W + A K V V+ + E L+ V + +++ Sbjct: 10 TASPESQQIHVWSLEADGKLTLVQVVDAPGQ-----VQPMVVSPNKEFLYVGVRPEFRVL 64 Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHS 312 + +N + A +S + + F+ + V++ L + + + Sbjct: 65 AYRITPDNGALTFAGEAALPGSPTHISTDRHGRFVFSASYNQGCVSVTPLHDGLPGETIT 124 Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 372 + SP N T+ + R+ ++ LS G + E AE E Sbjct: 125 VVEGLEGCHSANISPDNRTLWVPALKQDRICLFTLSDDGFLSAQEPAEVTTVEGAGPR-- 182 Query: 373 HTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 415 H ++PN+ + C ++ + VW++ + N E + Sbjct: 183 HMV------FHPNQQYGYCVNELNSSIDVWELKDPKGNIECVQ 219 Score = 28.2 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 40/119 (33%), Gaps = 11/119 (9%) Query: 201 TICLWDISAVPKEGKVVDAK----TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD 256 +I +W++ + V F+G D+ L+ D+ I Sbjct: 202 SIDVWELKDPKGNIECVQTLDMMPPDFSG-VRWAADIHITPDGRHLYA---CDRTASIIT 257 Query: 257 TRSNNTSKPSHSVDA-HTAEVNCLSFN--PYSEFILATGSADKTVALWDLRNLKLKLHS 312 S + +V+ E FN ++++A G +A++D+ + L Sbjct: 258 VFSVSEDGSVLAVEGYQPTETQPRGFNLDHSGKYLIAAGQKSHHIAVYDIVGEQGLLQE 316 >4YHC-A nrPDB Length = 468 Score = 35.9 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 38/94 (40%), Gaps = 5/94 (5%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285 H + ++ + F SV D+ L++WD R +K S + + ++ +P Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRSLVVWDLRQW-CTKLVLSKEQMPRTLKAIALDPQG 86 Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDE 319 ++ + + T+ + ++ + L L H Sbjct: 87 NYV--SLFSKDTLFILNVESPSLMLQHSY-HSKP 117 >1C5K-A nrPDB Length = 439 Score = 35.2 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 26/196 (13%), Positives = 62/196 (31%), Gaps = 17/196 (8%) Query: 217 VDAKTIFTGHTAV--VEDVSWHLLHESL-FGSVADDQKLMIWDTRSNNTSKPSHSVDAHT 273 D F H + + +W L + + + ++ T +N + S H Sbjct: 188 YDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHN 247 Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333 +F+P + S ++ L+ + ++ + + W P ++ + Sbjct: 248 G---APAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLA 304 Query: 334 ASSGTDRRLNVWDLS-----------KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSW 382 +S R V+ ++ + + Q + + DG ++ G I+ Sbjct: 305 FTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDL 364 Query: 383 NPNEPWVICSVSEDNI 398 V+ S D Sbjct: 365 ATGGVQVLSSTFLDET 380 >4R40-A nrPDB Length = 411 Score = 34.8 bits (78), Expect = 0.077, Method: Composition-based stats. Identities = 23/188 (12%), Positives = 60/188 (31%), Gaps = 19/188 (10%) Query: 217 VDAKTIFTGHTAV--VEDVSWHLLHESL-FGSVADDQKLMIWDTRSNNTSKPSHSVDAHT 273 D F H + + +W + + + + ++ T +N + S H Sbjct: 168 YDGYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHN 227 Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333 +F+P + S ++ L+ + ++ + + W P ++ + Sbjct: 228 G---APAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLA 284 Query: 334 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSV 393 +S R V+ ++ G G P+ + G +P+ +++ Sbjct: 285 YTSDQGGRPQVYKVNING----------GVPQRITWEGSQNQN---ADVSPDGKFLVLVS 331 Query: 394 SEDNIMQV 401 S + Sbjct: 332 SNGGAQHI 339 >1RI6-A nrPDB Length = 343 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 33/235 (14%), Positives = 85/235 (36%), Gaps = 22/235 (9%) Query: 186 NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGS 245 + + ++ S + I +W+++ + + G V+ + L+ Sbjct: 2 SLKQTVYIAS-PESQQIHVWNLN--HEGALTLTQVVDVPG---QVQPMVVSPDKRYLYVG 55 Query: 246 VADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 305 V + +++ + ++ + + A + +S + +F+ V++ L + Sbjct: 56 VRPEFRVLAYRIAPDDGALTFAAESALPGSLTHISTDHQGQFVFVGSYNAGNVSVTRLED 115 Query: 306 L-KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPP 364 + + D SP N T+ + R+ ++ +S G + + AE Sbjct: 116 GLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTV 175 Query: 365 ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVD 419 E H ++PNE + C ++ + VW++ DP G+++ Sbjct: 176 EGAGPR--HMV------FHPNEQYAYCVNELNSSVDVWELK-------DPHGNIE 215 >5GRS-A nrPDB Length = 396 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 37/86 (43%), Gaps = 4/86 (4%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285 H + ++ + F SV D+ L++WD R +K S + + ++ +P Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRCLVVWDLRQW-CTKLVLSKEQMPRTLKAIALDPQG 86 Query: 286 EFILATGSADKTVALWDLRNLKLKLH 311 ++ + + T+ + ++ + L L Sbjct: 87 NYV--SLFSKDTLFILNVESPSLMLQ 110 Score = 31.7 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 5/68 (7%) Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 352 S D T+ R + +H H+ +I ++ S + +T AS G DR L VWDL + Sbjct: 10 STDTTLHEEKFRIEPVPVH----HQLDILKIAVSENYKT-FASVGLDRCLVVWDLRQWCT 64 Query: 353 EQSPEDAE 360 + + Sbjct: 65 KLVLSKEQ 72 >6N8P-A nrPDB Length = 979 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 28/89 (31%), Gaps = 13/89 (14%) Query: 235 WHLLHESLFGS-------VADDQK---LMIWDTRSNNTSKPSHSVDAHTAEV---NCLSF 281 W + S + L +W+ S+ + + L+ Sbjct: 360 WPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTP 419 Query: 282 NPYSEFILATGSADKTVALWDLRNLKLKL 310 P +L TG D TV WD + L+L Sbjct: 420 APPQRDLLLTGHEDGTVRFWDASGVCLRL 448 Score = 32.9 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 88/298 (29%), Gaps = 62/298 (20%) Query: 134 PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL--SWNPNLSG 191 P++P I V+++D R+ H L W Sbjct: 187 PRDPNQILIGYSRGLVVIWDLQGS--------------RVLYHFLSSQQLENIWWQRDGR 232 Query: 192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG--HTAVVEDVSWHLLHESL------- 242 L+S D + C W +S+ ++ + + + + G + + W + L Sbjct: 233 LLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPY-GPFPCKAITRILWLTTRQGLPFTIFQG 291 Query: 243 -----------FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291 SV D + +D S + +A A + L Sbjct: 292 GMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLT-EADPAATF------DDPYALVV 344 Query: 292 GSADKTVALWDLRN-LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 + ++ V + DL+ + + S H I L +W+ +I Sbjct: 345 LAEEELVVI-DLQTAGWPPVQLPYLASLHCSAITCSHHVSNI--------PLKLWE--RI 393 Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 408 S ++A E G + + P + ++ + ED ++ W + Sbjct: 394 IAAGSRQNAHFSTMEWPIDGG------TSLTPAPPQRDLLLTGHEDGTVRFWDASGVC 445 Score = 32.5 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 50/146 (34%), Gaps = 11/146 (7%) Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290 ++ L + +D + WD S + + + T V +P F + Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDA-SGVCLRLLYKLS--TVRVFLTDTDPNENF--S 469 Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350 D+ L + + +IF ++S LA +GT ++ V +L+ Sbjct: 470 AQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYS----GYLAVAGTAGQVLVLELNDE 525 Query: 351 GEEQSPEDAEDG--PPELLFIHGGHT 374 EQ+ E E + + GH Sbjct: 526 AAEQAVEQVEADLLQDQEGYRWKGHE 551 >5CWW-B nrPDB Length = 595 Score = 33.6 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 44/108 (40%), Gaps = 8/108 (7%) Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH---T 374 D+I Q+ SP+ + + + +++ L + P H Sbjct: 115 DDIRQLVMSPNQDFLAVLTS--HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 375 AKISDFSWNPNE--PWVICSVSEDNIMQVWQMAE-NIYNDEDPEGSVD 419 + + W+P + +V+ED I++VW+++ + + + P ++D Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWTFDAPTLAID 220 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 46/146 (31%), Gaps = 26/146 (17%) Query: 274 AEVNCLSFNPYSEFILATGSADKTVALW-----------DLRNLKLKLHSF--ESH---K 317 ++ L +P +F+ S TV + D K K + +H + Sbjct: 115 DDIRQLVMSPNQDFLAVLTS--HTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSR 172 Query: 318 DEIFQVQWSPHN--ETILASSGTDRRLNVWDLSKIGEE--QSPEDAEDGPPELLFIHGGH 373 + W P L + D + VW+LS +P A D + Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWTFDAPTLAIDLKKLADATYLDQ 232 Query: 374 TAKISDFS----WNPNEPWVICSVSE 395 +S + ++P+ + + + Sbjct: 233 DFGVSTSATNKGFSPDAFDMEVAAAC 258 >5BPW-A nrPDB Length = 843 Score = 32.9 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 35/93 (37%), Gaps = 3/93 (3%) Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292 + W L ++++ S + + EV CL++ P + + Sbjct: 26 LVWSPK-RDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFAL 84 Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 325 + K + L D+ + LHSF S + + + W Sbjct: 85 ADTKKIVLCDVEKPE-SLHSF-SVEAPVSCMHW 115 >6GC1-A nrPDB Length = 579 Score = 32.9 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 45/143 (31%), Gaps = 18/143 (12%) Query: 177 QKEGYGLSWNPNLSGHLLSASDD--HTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234 +S HL+ D + D+ V K+ V+ Sbjct: 440 SSTVRTVSLKDGAVKHLVGGERDPMNLFAFGDVDGVGINAKLQHPL-----------GVT 488 Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP---YSEFILAT 291 W L+ + + + K+ + D ++ N + + T V SF L Sbjct: 489 WDKKRNLLYVADSYNHKIKVVDPKTKNC--TTLAGTGDTNNVTSSSFTESTFNEPGGLCI 546 Query: 292 GSADKTVALWDLRNLKLKLHSFE 314 G + + + D N ++K+ E Sbjct: 547 GENGELLYVADTNNHQIKVMDLE 569 >5AJA-A nrPDB Length = 361 Score = 32.9 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 14/94 (14%), Positives = 39/94 (41%), Gaps = 5/94 (5%) Query: 245 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 D+ L+ R + + ++ ++ C +F+ F++ G+ + L+++ Sbjct: 12 GGCFDRHLIFSRFRPISVFREANEDES---GFTCCAFSARERFLML-GTCTGQLKLYNVF 67 Query: 305 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 338 + + + S+ H I ++ S +L S+ Sbjct: 68 SGQEE-ASYNCHNSAITHLEPSRDGSLLLTSATW 100 >4AV8-A nrPDB Length = 339 Score = 32.5 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 16/98 (16%), Positives = 37/98 (37%), Gaps = 13/98 (13%) Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 ++H + + V+ + + ++A+ D L ++G F G Sbjct: 176 KAHANPVKMVRLNRKGD-MVATCSQDGTL-----------IRVFQTDNGVLVREFRRGLD 223 Query: 374 TAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYND 411 I D W+P+ + VS+ + V+++ + N Sbjct: 224 RTSIIDMRWSPDGSK-LAVVSDKWTLHVFEVFNDAENK 260 >4MDV-A nrPDB Length = 375 Score = 30.9 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 24/35 (68%), Gaps = 1/35 (2%) Query: 35 VMTHALEWPSLTAQWLPDVTRPEG-KDFSIHRLVL 68 V+ +A++ PSL A+WL D G KD+++ RL++ Sbjct: 283 VLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLI 317 >5XQL-A nrPDB Length = 291 Score = 30.2 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 26/72 (36%), Gaps = 7/72 (9%) Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-HTAEVN--CLSFN 282 H +VE ++ ++ FGS D +W+ H + H EV+ + Sbjct: 141 HARIVERPAFSVVGMEYFGSAPGDTIGQLWERFIP----REHEIAGKHDPEVSYGICAQQ 196 Query: 283 PYSEFILATGSA 294 P EF G Sbjct: 197 PNGEFHYVAGFE 208 >6IGR-A nrPDB Length = 656 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 59/192 (30%), Gaps = 30/192 (15%) Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL---ATGSADKTVALWDLRNLKLKL 310 +W + +H+ + ++P + + + G + L L+ + + Sbjct: 61 LWLSEGGAARPLTHAETGRGD--SAPRWSPDGQNLAFVRSAGEVKAALMLLPLKGGEARR 118 Query: 311 HSFESHKDEIFQVQWSPHNETILASSGTDR-------------RLNVWDLSKIG---EEQ 354 + K+ + QWSP I ++ D V+ + E Sbjct: 119 VTHF--KNGVSGPQWSPDGRFIAFTTTADTEDKRDERGEARVLTRPVYRANGADWLPERP 176 Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW---QMAENIYND 411 + D + L I SW P+ V+ SED W Q +++Y+ Sbjct: 177 AALWLYDVEADKLREWYAPEIGIGALSWWPDSRGVLIVQSEDE----WQASQWRQDVYDL 232 Query: 412 EDPEGSVDPEGQ 423 P Q Sbjct: 233 PLPTADAPAAPQ 244 >1K3I-A nrPDB Length = 656 Score = 29.8 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 20/137 (14%), Positives = 40/137 (29%), Gaps = 6/137 (4%) Query: 255 WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSF 313 WD + S + +V H +S + + ++ G+ K +L+D + + Sbjct: 224 WDPSTGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTGGNDAKKTSLYDSSSDSWIPGPDM 283 Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373 + + S + K GE SP ++ Sbjct: 284 QVARGYQSSATMS-DGRVFTIGGSWSGGV----FEKNGEVYSPSSKTWTSLPNAKVNPML 338 Query: 374 TAKISDFSWNPNEPWVI 390 TA + N W+ Sbjct: 339 TADKQGLYRSDNHAWLF 355 >1OI2-A nrPDB Length = 366 Score = 29.4 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 46/120 (38%), Gaps = 16/120 (13%) Query: 189 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT--AVVEDVSWHLLHESLFGSV 246 L++ S T+ WD + + + + +G A+V ++ L L+G Sbjct: 249 FDTLLVNGSYHRTLRFWDYQQGSWQEEQQTKQPLQSGDRVIALVNNLGATPL-SELYG-- 305 Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAH--TAEVNCLSFNPYSEFILATGSADKTVALWDLR 304 +++ + + +++ + A L +S +L D+T+ALWD Sbjct: 306 -------VYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKV--DDETLALWDAP 356 >6HA9-A nrPDB Length = 396 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 28/87 (32%), Gaps = 5/87 (5%) Query: 49 WLPDVTRPEGKD--FSIHRLV---LGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKG 103 WL + P KD + + + TH D HL+ A PN + +S Sbjct: 141 WLENNITPAKKDENNAKQKAFWEQIATHLRDFDEHLLFAGTNAPNAENAEQMDVLNSYLQ 200 Query: 104 EFGGFGSVSGKIEIEIKINHEGEVNRA 130 F +G + +G V Sbjct: 201 TFVDAVRSTGGKNAYRVLVLQGPVTDI 227 >3LV4-A nrPDB Length = 456 Score = 29.0 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 56/170 (32%), Gaps = 13/170 (7%) Query: 28 TPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLP 87 P +Y+ + EW W PDVT+ E F ++ ++ L +A Sbjct: 57 IPNVYEELKET-FEWAESDTLWAPDVTQLEDGKFYMYY--NACRGDSPRSALGLAVADDI 113 Query: 88 NDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCI-IATKTPS 146 + S G+ H V+ + QN + + + S Sbjct: 114 EGPYKNKGIFLKSGMDGISNDGTP------YDATKHPNVVDPHTFFDQNGKLWMVYGSYS 167 Query: 147 SDVLVFDYTKHPSKPDPSGECNPDLRLRG-HQK-EGYGLSWNPNLSGHLL 194 + + + K P P G+ + G H + EG + ++P + L Sbjct: 168 GGIFILEMDKKTGFPLP-GQGYGKKLIGGNHSRIEGAYILYHPETQYYYL 216 >3U14-A nrPDB Length = 535 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 28/209 (13%), Positives = 63/209 (30%), Gaps = 25/209 (11%) Query: 198 DDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLL---------HESLFGS--- 245 D T LW + + ++ GH + V W +E +F Sbjct: 56 YDKTAKLWHLYFQYNPNATAWGQPLYWGHATSNDLVHWDEHEIAIGPEHDNEGIFSGSIV 115 Query: 246 VADDQKLMIWD--TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL 303 V + ++ N ++ + + ++F+ + + + D+ Sbjct: 116 VDHNNTSGFFNSSIDPNQRIVAIYTNNIPDNQTQDIAFSLDGGYTFTKYENNPVI---DV 172 Query: 304 RNLKLKLHSFESHKD---EIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360 + + + H+D I V S + + S L W L+ + Sbjct: 173 SSNQFRDPKVFWHEDSNQWIMVVSKSQEYKIQIFGSA---NLKNWVLNSNFSSGYYGNQY 229 Query: 361 DGPP--ELLFIHGGHTAKISDFSWNPNEP 387 + P E+ + + + + NP P Sbjct: 230 ECPGLIEVPIENSDKSKWVMFLAINPGSP 258 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.122 0.342 Lambda K H 0.267 0.0373 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,418,622 Number of Sequences: 36641 Number of extensions: 633503 Number of successful extensions: 5512 Number of sequences better than 10.0: 159 Number of HSP's better than 10.0 without gapping: 192 Number of HSP's successfully gapped in prelim test: 99 Number of HSP's that attempted gapping in prelim test: 1255 Number of HSP's gapped (non-prelim): 1066 length of query: 425 length of database: 10,336,785 effective HSP length: 100 effective length of query: 325 effective length of database: 6,672,685 effective search space: 2168622625 effective search space used: 2168622625 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 60 (27.9 bits)