BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q5XFW8 (322 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3BG0-A nrPDB 635 0.0 4L9O-A nrPDB 315 2e-86 4YCZ-A nrPDB 305 2e-83 3JRO-A nrPDB 301 3e-82 3JRP-A nrPDB 297 3e-81 4BZK-B nrPDB 296 9e-81 5A9Q-7 nrPDB 149 2e-36 3F3P-A nrPDB 128 3e-30 3FM0-A nrPDB 94 1e-19 2HES-X nrPDB 65 4e-11 1VYH-C nrPDB 65 5e-11 6QX9-5O nrPDB 64 9e-11 5WJC-A nrPDB 55 3e-08 5NNZ-B nrPDB 51 7e-07 5OQL-J nrPDB 51 7e-07 4XYI-A nrPDB 51 9e-07 6MZM-G nrPDB 50 2e-06 4V8M-A7 nrPDB 50 2e-06 6F3T-A nrPDB 50 2e-06 5Y1U-A nrPDB 49 2e-06 5FL8-q nrPDB 49 3e-06 3JB9-L nrPDB 49 3e-06 6BX3-A nrPDB 48 6e-06 2P9P-C nrPDB 48 6e-06 6EOJ-D nrPDB 46 3e-05 4PSX-B nrPDB 46 3e-05 5OQL-d nrPDB 45 3e-05 6G51-g nrPDB 45 3e-05 5FA5-B nrPDB 45 4e-05 5WYJ-BC nrPDB 45 4e-05 5L9T-R nrPDB 44 1e-04 5M25-A nrPDB 43 2e-04 2H9P-A nrPDB 43 2e-04 4BTS-AR nrPDB 42 3e-04 4G56-B nrPDB 42 5e-04 5Y88-O nrPDB 41 8e-04 6CHG-A nrPDB 41 8e-04 3JAP-g nrPDB 41 9e-04 4LG8-A nrPDB 40 0.001 6EMK-B nrPDB 40 0.001 6N9G-C nrPDB 40 0.001 5Z56-q nrPDB 40 0.001 5K1B-B nrPDB 40 0.002 2AQ5-A nrPDB 40 0.002 3C9C-A nrPDB 39 0.002 4AEZ-A nrPDB 39 0.002 5MZH-A nrPDB 39 0.002 3DM0-A nrPDB 39 0.003 3ODT-A nrPDB 39 0.003 3W15-A nrPDB 38 0.005 6QX9-4B nrPDB 38 0.006 5OPT-p nrPDB 38 0.007 5FVM-C nrPDB 38 0.007 3CFV-B nrPDB 37 0.008 4V7E-Bg nrPDB 37 0.008 5UZ7-B nrPDB 37 0.014 2YNP-A nrPDB 37 0.016 4N14-A nrPDB 36 0.018 5N4A-A nrPDB 36 0.018 5GAN-H nrPDB 36 0.020 3MKQ-A nrPDB 36 0.020 5LCW-Q nrPDB 36 0.023 4GGA-A nrPDB 36 0.028 5G04-R nrPDB 35 0.032 4XFV-A nrPDB 35 0.042 1NR0-A nrPDB 35 0.046 4U1E-I nrPDB 35 0.062 6J6H-n nrPDB 34 0.077 3DWL-C nrPDB 34 0.11 4V6W-Ag nrPDB 33 0.14 3JB9-g nrPDB 33 0.18 5I2T-A nrPDB 33 0.18 5WLC-LO nrPDB 33 0.19 6ID0-T nrPDB 33 0.21 4A11-B nrPDB 32 0.25 6HHQ-h nrPDB 32 0.46 5YZG-W nrPDB 31 0.61 6QDV-o nrPDB 31 0.69 5WBU-D nrPDB 31 0.70 5CXB-B nrPDB 31 0.82 5WLC-LW nrPDB 30 1.1 6HQA-B nrPDB 30 1.2 6DKH-A nrPDB 30 1.3 5OQL-L nrPDB 30 1.3 5CXC-A nrPDB 29 2.4 4OWR-A nrPDB 29 3.3 5WYK-BB nrPDB 28 3.6 6GMH-W nrPDB 28 4.0 5DIZ-A nrPDB 28 4.2 5K0Y-T nrPDB 28 4.4 6DAM-A nrPDB 28 5.6 4X8N-A nrPDB 27 8.9 >3BG0-A nrPDB Length = 316 Score = 635 bits (1638), Expect = 0.0, Method: Compositional matrix adjust. Identities = 307/316 (97%), Positives = 313/316 (99%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV Sbjct: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 WQVAWAHPMYGNILASCSYDRKVIIW+EENGTWEK+HEH+GHDSSVNSVCWAPHDYGLIL Sbjct: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID PSGQKPNYIK Sbjct: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 180 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 +FASGGCDNLIKLW+EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV Sbjct: 181 RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 Query: 241 FIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 FIWTCDDAS N WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI Sbjct: 241 FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 Query: 301 SDVNKGQGSVSASITE 316 SDVNKGQGSVSAS+TE Sbjct: 301 SDVNKGQGSVSASVTE 316 >4L9O-A nrPDB Length = 349 Score = 315 bits (807), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 161/302 (53%), Positives = 205/302 (67%), Gaps = 18/302 (5%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 T+ +H+D+IHDA +DYYG RLATCSSD+++KIF++ Q L+ L GHEGPVWQVAWA Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA 122 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 HP +G ILASCSYD KV+IWKE+NG W K EHS H +SVNSV WAPH+YG +L C SSD Sbjct: 123 HPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 182 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 G IS++ + G E I H IG NA SWAP + P+ ++F SGG Sbjct: 183 GKISIVEFKDGGALEPIVI-QGHAIGVNAASWAPISL------------PDNTRRFVSGG 229 Query: 187 CDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 CDNL+K+WR ++ + + EE+ + HSDWVRDVAW+PS L S IA+ SQD V IWT Sbjct: 230 CDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPS-RLSKSYIATASQDRTVLIWTK 288 Query: 246 DDASGNMW--SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 D S N W P KF DV W SWS++ N+LA+SGGDNKVTLWKE++ G+W +V Sbjct: 289 DGKS-NKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEV 347 Query: 304 NK 305 ++ Sbjct: 348 DQ 349 >4YCZ-A nrPDB Length = 876 Score = 305 bits (780), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 150/300 (50%), Positives = 207/300 (69%), Gaps = 6/300 (2%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 ++ H+DMIHDA +DYYG RLATCSSDR++KIF++ Q L L+GH+G VW V+WAH Sbjct: 13 ANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAH 72 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P YGNILAS YD KV+IW+E NG W++ + + H +SVN V W+PH+ G +LAC SSDG Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 +S+L + + WE I +AH +G N+VSWAPA PGS++ G K ++F +GG Sbjct: 133 NVSVLEFR-DNSWE-HSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGS 190 Query: 188 DNLIKLW-REEEDGQWK-EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 DN +K+W + +K E + L H+DWVRDVAW+P++ L S IAS S+D V IWT Sbjct: 191 DNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTV-LQKSYIASASEDRTVRIWTS 249 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 D A+ W+ K+L+ F+ VW VSWS++ N+LA SGGDNKVTLWKE++ G+W C+ + + Sbjct: 250 DPANPLQWNCKVLN-FDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIEE 308 >3JRO-A nrPDB Length = 753 Score = 301 bits (770), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 156/300 (52%), Positives = 203/300 (67%), Gaps = 14/300 (4%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MV + N +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPV Sbjct: 1 MVVIAN----AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 W+V WAHP +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L Sbjct: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 SSDG +S++ + G I +AH IG N+ SWAPA + + +G K + + Sbjct: 117 LVASSDGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEED--GEHNGTKES--R 171 Query: 181 KFASGGCDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 KF +GG DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD Sbjct: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRT 230 Query: 240 VFIWTCDDASGNMWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 IWT D+ G W LL KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W Sbjct: 231 CIIWTQDNEQGP-WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 >3JRP-A nrPDB Length = 379 Score = 297 bits (761), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 157/308 (50%), Positives = 207/308 (67%), Gaps = 14/308 (4%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MV + N +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPV Sbjct: 3 MVVIAN----AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 58 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 W+V WAHP +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L Sbjct: 59 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 118 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 SSDG +S++ + G I +AH IG N+ SWAPA + + +G K + + Sbjct: 119 LVASSDGKVSVVEFKENGT-TSPIIIDAHAIGVNSASWAPATIEED--GEHNGTKES--R 173 Query: 181 KFASGGCDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 KF +GG DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD Sbjct: 174 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRT 232 Query: 240 VFIWTCDDASGNMWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 IWT D+ G W LL KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W Sbjct: 233 CIIWTQDNEQGP-WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 291 Query: 298 VCISDVNK 305 +V++ Sbjct: 292 EPAGEVHQ 299 >4BZK-B nrPDB Length = 297 Score = 296 bits (758), Expect = 9e-81, Method: Compositional matrix adjust. Identities = 157/308 (50%), Positives = 207/308 (67%), Gaps = 14/308 (4%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MV + N +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPV Sbjct: 1 MVVIAN----AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 W+V WAHP +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L Sbjct: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 SSDG +S++ + G I +AH IG N+ SWAPA + + +G K + + Sbjct: 117 LVASSDGKVSVVEFKENGT-TSPIIIDAHAIGVNSASWAPATIEED--GEHNGTKES--R 171 Query: 181 KFASGGCDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 KF +GG DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD Sbjct: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRT 230 Query: 240 VFIWTCDDASGNMWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 IWT D+ G W LL KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W Sbjct: 231 CIIWTQDNEQGP-WKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289 Query: 298 VCISDVNK 305 +V++ Sbjct: 290 EPAGEVHQ 297 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 72/205 (35%), Gaps = 34/205 (16%) Query: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQK 175 YG LA SSD I + GE + + H V WA Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLIDTLT-GHEGPVWRVDWA---------------H 63 Query: 176 PNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS 235 P + AS D + +W+EE +G+W + HS V V WAP P +AS Sbjct: 64 PKFGTILASCSYDGKVLIWKEE-NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS- 121 Query: 236 QDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSIT-------------ANILAVSGG 282 DG+V + + SP ++ V SW+ + G Sbjct: 122 -DGKVSV--VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 178 Query: 283 DNKVTLWKESVDGQWVCISDVNKGQ 307 DN V +WK + D Q + +G Sbjct: 179 DNLVKIWKYNSDAQTYVLESTLEGH 203 >5A9Q-7 nrPDB Length = 360 Score = 149 bits (375), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 109/351 (31%), Positives = 164/351 (46%), Gaps = 51/351 (14%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRGHEGPVWQ 62 V ++ H+D+IHD D++G R+ATCSSD+SVK++D G A + H G VW+ Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGT----------WEKTHEHSGHDSSVNSVCWA 112 V WAHP +G +LASCS+DR +W+E G W K +SV V +A Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 113 PHDYGLILACGSSDGAISLLT---YTGEGQWEVKKINNAHTIGCNAVSW--------APA 161 P GL+LA S+DG + + QW ++ + + C+ +SW +P Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPM 181 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWA 221 + GS P+ I ++ E ++ + + L +D V D+A+A Sbjct: 182 IAVGSDDSSPNAMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFA 228 Query: 222 PSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKF-----------NDVVWHVSW 270 P++G +A ++D R+F T + S KF N VW VSW Sbjct: 229 PNLGRSFHILAIATKDVRIF--TLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSW 286 Query: 271 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS-VSASITEGQQN 320 +IT +LA SG D V LWK + W C + + KG GS V+ S +G N Sbjct: 287 NITGTVLASSGDDGCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336 >3F3P-A nrPDB Length = 351 Score = 128 bits (321), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 99/364 (27%), Positives = 165/364 (45%), Gaps = 76/364 (20%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV-RNGGQILIADL-RGHEGPVWQ 62 + D+ H+D++HD D+YG +ATCSSD+ +K+F + ++ ++D R H+ + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEE-------NGTWEKTHEHSGHDSSVNSVCWAPHD 115 + WA P YG I+AS SYD+ V +W+E+ W K + S+ SV +AP Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 116 YGLILACGSSDGAISLL---------TYTGEGQWEVKKINNAHTIGCN-AVSWAPAVVPG 165 GL LAC +DG + L ++T + +V I A+ + + +SW P+ Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 166 SLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 +K A + I +++ +DG+ KL H +R ++WAPSIG Sbjct: 183 --------------EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 227 Query: 226 LPTSTIASCSQDGRVFIWTCDD-----------ASGNMW--------------------- 253 IA+ +DGR+ I+ + + NM+ Sbjct: 228 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 287 Query: 254 -------SPKLLHKFND---VVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 +LL + +D VW VSW++T IL+ +G D KV LWK + ++ C+S + Sbjct: 288 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 347 Query: 304 NKGQ 307 Q Sbjct: 348 TAQQ 351 >3FM0-A nrPDB Length = 345 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 83/280 (29%), Positives = 125/280 (44%), Gaps = 39/280 (13%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS S+D Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS--PCGNYLASASFDATT 85 Query: 84 IIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 IWK+ +E GH++ V SV WAP G +LA S D ++ + E ++E Sbjct: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143 Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWK 203 + N+HT V W P+ + AS D+ +KL+REEED W Sbjct: 144 SVLNSHTQDVKHVVWHPSQ-----------------ELLASASYDDTVKLYREEED-DWV 185 Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASGNM 252 LE H V +A+ PS +ASCS D V IW C + + Sbjct: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241 Query: 253 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 291 L F+ ++ ++W LA + GD+ + +++E Sbjct: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 110/250 (44%), Gaps = 30/250 (12%) Query: 48 ILIADLRGH-EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTW-EKTHEHSGHDSS 105 +L+ + H + W +AW +P G +LASC DR++ IW E +W K+ GH + Sbjct: 6 VLLGRVPAHPDSRCWFLAW-NPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT 63 Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165 V V W+P G LA S D A + + + +E H +V+WAP+ G Sbjct: 64 VRKVAWSP--CGNYLASASFD-ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS---G 117 Query: 166 SLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 +L+ A+ D + +W +E+ +++ L +H+ V+ V W PS Sbjct: 118 NLL--------------ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNK 285 L +AS S D V ++ + + L VW +++ + LA D Sbjct: 164 L----LASASYDDTVKLYR--EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRT 217 Query: 286 VTLWKESVDG 295 V +W++ + G Sbjct: 218 VRIWRQYLPG 227 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 81/304 (26%), Positives = 115/304 (37%), Gaps = 56/304 (18%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H+ + G LA+ S D + I+ + L GHE V VAWA G Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS--G 117 Query: 72 NILASCSYDRKVIIWK-EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 N+LA+CS D+ V +W+ +E +E + H V V W P +LA S D + Sbjct: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE--LLASASYDDTVK 175 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 L E W + A G + W SL PSGQ + AS D Sbjct: 176 LYREE-EDDW----VCCATLEGHESTVW-------SLAFDPSGQ------RLASCSDDRT 217 Query: 191 IKLWREE------------EDGQWKEEQKLEA-HSDWVRDVAWAPSIGLPTSTIASCSQD 237 +++WR+ D WK L HS + D+AW G + +C D Sbjct: 218 VRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTG---ALATACGDD 274 Query: 238 G-RVFIWTCDDASGNMWSPKL-----LHK-----FNDVVWHVSWSITANILAVSGGDNKV 286 RVF +D + + P LH+ N V W+ +LA D +V Sbjct: 275 AIRVFQ---EDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASCSDDGEV 328 Query: 287 TLWK 290 WK Sbjct: 329 AFWK 332 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 60/143 (41%), Gaps = 22/143 (15%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-------------ILIADLRG-HE 57 HE + D G RLA+CS DR+V+I+ G I L G H Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEK------THEHSGHDSSVNSVCW 111 ++ +AW + G + +C D + ++ N ++ H H H VN V W Sbjct: 253 RTIYDIAWCQ-LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAW 311 Query: 112 APHDYGLILACGSSDGAISLLTY 134 P + GL+ +C S DG ++ Y Sbjct: 312 NPKEPGLLASC-SDDGEVAFWKY 333 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 6/123 (4%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 AS G D I++W E D + E H VR VAW+P + +AS S D Sbjct: 31 LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTC 86 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCIS 301 IW + L + V V+W+ + N+LA D V +W+ + ++ C+S Sbjct: 87 IWK--KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVS 144 Query: 302 DVN 304 +N Sbjct: 145 VLN 147 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 8/93 (8%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIF------DVRNGGQILIADL-RGHE 57 I T+ H I+D LAT D ++++F D + L A L + H Sbjct: 244 ICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHS 303 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEEN 90 V VAW +P +LASCS D +V WK + Sbjct: 304 QDVNCVAW-NPKEPGLLASCSDDGEVAFWKYQR 335 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 24/42 (57%), Gaps = 1/42 (2%) Query: 266 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 W ++W+ +LA GGD ++ +W D W+C S +++G Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDS-WICKSVLSEGH 60 >2HES-X nrPDB Length = 330 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 90/197 (45%), Gaps = 27/197 (13%) Query: 119 ILACGSSDGAISLLTYTGEGQWEVKKIN-NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPN 177 ILA GS+D I L++ + + ++ AH +V+W P Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRP----------------- 68 Query: 178 YIKKFASGGCDNLIKLWREEEDGQWKEEQKL----EAHSDWVRDVAWAPSIGLPTSTIAS 233 + A+G D+ + +W +EE E L E H + V+ VAW+ +A+ Sbjct: 69 HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSN----DGYYLAT 124 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 CS+D V+IW D++ +L + + V HV W + +LA S D+ V +WK+ Sbjct: 125 CSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKD-Y 183 Query: 294 DGQWVCISDVNKGQGSV 310 D W C++ +N +G+V Sbjct: 184 DDDWECVAVLNGHEGTV 200 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 106/241 (43%), Gaps = 19/241 (7%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL--IADLRGHEGPVWQVAWAHPM 69 HE+ + G LATCS D+SV I++ G+ I+ L+ H V V W HP Sbjct: 106 HENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIW-HPS 164 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +LAS SYD V IWK+ + WE +GH+ +V S + + L GS D + Sbjct: 165 EA-LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTV 223 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + Y G+ + ++ C A++P Q + AS G D Sbjct: 224 RVWKYMGDDE------DDQQEWVC------EAILPDVHKRQVYNVAWGFNGLIASVGADG 271 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI-ASCSQDGRVFIWTCDDA 248 ++ ++ EE DG+WK K A V ++ + L TI A+ DG V W+ + A Sbjct: 272 VLAVY-EEVDGEWKVFAK-RALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKA 329 Query: 249 S 249 + Sbjct: 330 A 330 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 122/295 (41%), Gaps = 49/295 (16%) Query: 21 MDYYGTRLATCSSDRSVKIFDVRNGGQILI--ADLRGHEGPVWQVAWAHPMYGNILASCS 78 D+ LAT S+DR +K+ V+ LI D H+ + VAW P + ++LA+ S Sbjct: 20 FDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAW-RP-HTSLLAAGS 77 Query: 79 YDRKVIIWKEENGTWEKTHEH------SGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 +D V IW +E ++T E GH++ V V W+ G LA S D ++ + Sbjct: 78 FDSTVSIWAKEESA-DRTFEMDLLAIIEGHENEVKGVAWSND--GYYLATCSRDKSVWIW 134 Query: 133 TYTGEG-QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 G ++E + H+ V W P+ AS D+ + Sbjct: 135 ETDESGEEYECISVLQEHSQDVKHVIWHPSEAL-----------------LASSSYDDTV 177 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASC--SQDGRVFIWTC---D 246 ++W++ +D W+ L H V W+ C S D V +W D Sbjct: 178 RIWKDYDD-DWECVAVLNGHEGTV----WSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDD 232 Query: 247 DASGNMWSPKLL----HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 + W + + HK V++V+W I +V G D + +++E VDG+W Sbjct: 233 EDDQQEWVCEAILPDVHKRQ--VYNVAWGFNGLIASV-GADGVLAVYEE-VDGEW 283 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 114/272 (41%), Gaps = 38/272 (13%) Query: 49 LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV--IIWKEENGTWEKTHEHSGHDSSV 106 LI L+ ++ +W ++ ILA+ S DRK+ + K ++ T + + H ++ Sbjct: 6 LIKSLKLYKEKIWSFDFSQ----GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAI 61 Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 SV W PH +LA GS D +S+ K+ + T + + A++ G Sbjct: 62 RSVAWRPHTS--LLAAGSFDSTVSIWA---------KEESADRTFEMDLL----AIIEGH 106 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKE-EQKLEAHSDWVRDVAWAPSIG 225 + N A+ D + +W +E G+ E L+ HS V+ V W PS Sbjct: 107 ENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEA 166 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG--D 283 L +AS S D V IW D + +L+ VW + T + + G D Sbjct: 167 L----LASSSYDDTVRIWK--DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDD 220 Query: 284 NKVTLWK-----ESVDGQWVC---ISDVNKGQ 307 + V +WK E +WVC + DV+K Q Sbjct: 221 STVRVWKYMGDDEDDQQEWVCEAILPDVHKRQ 252 >1VYH-C nrPDB Length = 410 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 75/284 (26%), Positives = 125/284 (44%), Gaps = 29/284 (10%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H D + D D+ G LA+CS+D ++K++D + G I + GH+ V V+ G Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQ--GFECIRTMHGHDHNVSSVSIMPN--G 204 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 + + S S D+ + +W+ + G KT +GH V V P+ G ++A S+D + + Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKT--FTGHREWVRMV--RPNQDGTLIASCSNDQTVRV 260 Query: 132 -LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK----FASGG 186 + T E + E+++ + H + C +SWAP S I + +G + K SG Sbjct: 261 WVVATKECKAELRE--HRHVVEC--ISWAPESSYSS-ISEATGSETKKSGKPGPFLLSGS 315 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D IK+W + G L H +WVR V + I SC+ D + +W Sbjct: 316 RDKTIKMW-DVSTGMCL--MTLVGHDNWVRGVLFHSGGKF----ILSCADDKTLRVWD-- 366 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 N K L+ V + + TA + D V +W+ Sbjct: 367 --YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/191 (29%), Positives = 83/191 (43%), Gaps = 33/191 (17%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH PV +V + HP++ +++ S S D + +W E G +E+T + GH SV + + Sbjct: 104 LSGHRSPVTRVIF-HPVF-SVMVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISF- 158 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 G +LA S+D I L + G +E + + H ++VS P G I Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVSIMPN---GDHI---- 207 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 S D IK+W E + G + H +WVR V L IA Sbjct: 208 ----------VSASRDKTIKMW-EVQTGYCV--KTFTGHREWVRMVRPNQDGTL----IA 250 Query: 233 SCSQDGRVFIW 243 SCS D V +W Sbjct: 251 SCSNDQTVRVW 261 Score = 35.0 bits (79), Expect = 0.041, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 80/183 (43%), Gaps = 33/183 (18%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-HP 68 T H + + + + GT +A+CS+D++V+++ V + A+LR H V ++WA Sbjct: 231 TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV--ATKECKAELREHRHVVECISWAPES 288 Query: 69 MY-----------------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 Y G L S S D+ + +W G T GHD+ V V + Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT--LVGHDNWVRGVLF 346 Query: 112 APHDYG-LILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW---APAVVPGSL 167 H G IL+C + D + + Y + K NAH ++ + AP VV GS Sbjct: 347 --HSGGKFILSC-ADDKTLRVWDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGS- 399 Query: 168 IDQ 170 +DQ Sbjct: 400 VDQ 402 >6QX9-5O nrPDB Length = 357 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 76/285 (26%), Positives = 116/285 (40%), Gaps = 40/285 (14%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 + HE ++ + G+ LA+ DR + +++V G A L+GH G V ++ + Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD- 120 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC-GSSDGA 128 G++L S S D+ V +W E G E+ GH S VNS C+ P G L C GS DG Sbjct: 121 -GSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNS-CY-PARRGPQLVCTGSDDGT 175 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 + L W+++K T AV DQ SGG D Sbjct: 176 VKL--------WDIRKKAAIQTF--QNTYQVLAVTFNDTSDQ-----------IISGGID 214 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 N IK+W ++ K + H+D V + S+ S + S + D V +W Sbjct: 215 NDIKVWDLRQN---KLTYTMRGHADSVTGL----SLSSEGSYLLSNAMDNTVRVWDVRPF 267 Query: 249 SGNMWSPKLL----HKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + K+ H F + SWS + +A D V +W Sbjct: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312 >5WJC-A nrPDB Length = 430 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/173 (29%), Positives = 81/173 (46%), Gaps = 18/173 (10%) Query: 12 HEDMIHDAQM-DYYGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGPVWQVAWAHPM 69 H D+++D Q + LA+ S D +++I D R N + ++ H + VA +P Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVA-INPF 292 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +LA+ S D+ V +W N +++ H GH+ V + W+PHD ILA S+D + Sbjct: 293 NDYLLATASADKTVALWDLRN-PYQRLHTLEGHEDEVYGLEWSPHDEP-ILASSSTDRRV 350 Query: 130 SL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAPAV--VPGSLID 169 + L GE G E+ ++ HT + SW P V GSL D Sbjct: 351 CIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLAD 403 >5NNZ-B nrPDB Length = 415 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 40/117 (34%), Positives = 60/117 (51%), Gaps = 8/117 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H+D I D+ DY G +AT S+D + +IF + IA L GHEG + ++++ +P Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSA--ATRKCIAKLEGHEGEISKISF-NPQ 356 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 GN L + S D+ IW + G + E GH + S A + G I+ GS D Sbjct: 357 -GNHLLTGSSDKTARIWDAQTGQCLQVLE--GHTDEIFSC--AFNYKGNIVITGSKD 408 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 55/106 (51%), Gaps = 8/106 (7%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85 T +AT S D + K++D++NG ++ LRGH + ++ + G+ + + S+D V++ Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYT--LRGHSAEI--ISLSFNTSGDRIITGSFDHTVVV 245 Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 W + G K + GH + ++S + D LIL GS D L Sbjct: 246 WDADTG--RKVNILIGHCAEISSASF-NWDCSLILT-GSMDKTCKL 287 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 53/108 (49%), Gaps = 8/108 (7%) Query: 5 INTVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 +NT++ H ++++ + YG ++AT S D++ K++ V G RGH + V Sbjct: 127 LNTLE-GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--CYHTFRGHTAEI--V 181 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 + ++A+ S D +W +NG E+ + GH + + S+ + Sbjct: 182 CLSFNPQSTLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSF 227 >5OQL-J nrPDB Length = 912 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 114/308 (37%), Gaps = 45/308 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKI--FDVRNGGQILIADLRGHEGPVWQVAWA--- 66 HED++ +D+ G +A+ S D + ++ D N A GH V VA Sbjct: 432 HEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVV 491 Query: 67 -------------HPMYGNILASCSYDRKVIIWK-----EENGTWEKTHEHSGHDSSVNS 108 HP L S S DR V ++ G + HD +N+ Sbjct: 492 PPANSEAFKNPLDHP--PAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINA 549 Query: 109 VCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 + +P+ G + A S D + + + EV+ I H G V +AP P Sbjct: 550 LDISPN--GKLFASASQDKTVKIWDVE---KLEVQGILRGHKRGVWTVRFAPLNTPVIQG 604 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWA-----PS 223 +Q S + +G D IKLW + + + E HS V V W S Sbjct: 605 EQGSVSGRGVV---LTGSGDKTIKLWNLSD---YTCIRTFEGHSHNVLKVVWLHISRDDS 658 Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGD 283 I AS D V +W + L D +W ++ NILA +G D Sbjct: 659 ITKTKVQFASAGADTLVKVWDANTGETEC----TLDNHEDRLWTLAVHSKTNILASAGSD 714 Query: 284 NKVTLWKE 291 +KVT W++ Sbjct: 715 SKVTFWRD 722 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 18/114 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H+ I+ + G A+ S D++VKI+DV I LRGH+ VW V +A P+ Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI--LRGHKRGVWTVRFA-PLN 598 Query: 71 GNIL-------------ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 ++ + S D+ + +W + T +T E GH +V V W Sbjct: 599 TPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFE--GHSHNVLKVVW 650 >4XYI-A nrPDB Length = 430 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 16/162 (9%) Query: 12 HEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIAD-LRGHEGPVWQVAWAHPM 69 H +++D Q + L + S D +++I D R + ++ HE PV VA+ +P Sbjct: 234 HTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAF-NPF 292 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +LA+ S D V +W ++ H GH+ V +V W+PHD IL S+D + Sbjct: 293 NDYLLATASADHTVALWDLRRLN-QRLHTLEGHEDEVYNVQWSPHDEP-ILVTSSTDRRV 350 Query: 130 SL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAP 160 + L+ GE G E+ ++ HT + +SW P Sbjct: 351 CVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNP 392 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 47/122 (38%), Gaps = 16/122 (13%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 A+ D+ + LW Q LE H D V +V W+P + + S D RV Sbjct: 297 LATASADHTVALWDLRRLNQ--RLHTLEGHEDEVYNVQWSPH---DEPILVTSSTDRRVC 351 Query: 242 IW---------TCDDASGNMWSPKLLH-KFNDVVWHVSWSITAN-ILAVSGGDNKVTLWK 290 +W T +D+ +H + V +SW+ +LA DN + +W Sbjct: 352 VWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Query: 291 ES 292 S Sbjct: 412 PS 413 >6MZM-G nrPDB Length = 800 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/104 (33%), Positives = 58/104 (55%), Gaps = 8/104 (7%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 +AT S+DR+V+++DV NG + I GH+GP+ + ++ G LA+ + D +V++W Sbjct: 642 VATGSADRTVRLWDVLNGNCVRI--FTGHKGPIHSLTFSP--NGRFLATGATDGRVLLWD 697 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 +G E GH +V S+ ++ G ILA GS D + L Sbjct: 698 IGHGLM--VGELKGHTDTVCSLRFSRD--GEILASGSMDNTVRL 737 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 91/237 (38%), Gaps = 37/237 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH GPV+ +++ N L S S D V +W + T+ + GH+ V ++ Sbjct: 539 LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQ--TFTCLVGYKGHNYPVWDTQFS 594 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P YG G D L ++ +I H N + P Sbjct: 595 P--YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHP------------ 637 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 NY+ A+G D ++LW + +G + H + + ++P+ +A Sbjct: 638 --NSNYV---ATGSADRTVRLW-DVLNGNCV--RIFTGHKGPIHSLTFSPN----GRFLA 685 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + + DGRV +W D G M L D V + +S ILA DN V LW Sbjct: 686 TGATDGRVLLW--DIGHGLMVGE--LKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 4/79 (5%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + T H+ IH G LAT ++D V ++D+ +G +++ +L+GH V + ++ Sbjct: 664 IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG--LMVGELKGHTDTVCSLRFSR 721 Query: 68 PMYGNILASCSYDRKVIIW 86 G ILAS S D V +W Sbjct: 722 D--GEILASGSMDNTVRLW 738 >4V8M-A7 nrPDB Length = 318 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 30/191 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH V VA ++ GN S S+D + +W +NG + ++ GH V SV ++ Sbjct: 63 LEGHSAFVSDVALSN--NGNFAVSASWDHSLRLWNLQNGQCQ--YKFLGHTKDVLSVAFS 118 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P + ++ G D A+ + GE + + AHT + V ++P+ +D P Sbjct: 119 PDNRQIV--SGGRDNALRVWNVKGECMHTLSR--GAHTDWVSCVRFSPS------LDAPV 168 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 SGG DNL+K+W + + L+ H+++V V +P S A Sbjct: 169 ---------IVSGGWDNLVKVW---DLATGRLVTDLKGHTNYVTSVTVSPD----GSLCA 212 Query: 233 SCSQDGRVFIW 243 S +DG +W Sbjct: 213 SSDKDGVARLW 223 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%) Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 ++ SGG DN +++W + G+ AH+DWV V ++PS+ P I S D Sbjct: 122 RQIVSGGRDNALRVWNVK--GECMHTLSRGAHTDWVSCVRFSPSLDAP--VIVSGGWDNL 177 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 V +W D A+G + + L + V V+ S ++ A S D LW Sbjct: 178 VKVW--DLATGRLVTD--LKGHTNYVTSVTVSPDGSLCASSDKDGVARLW 223 Score = 27.3 bits (59), Expect = 9.4, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 18/139 (12%) Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKE------EQKLEAHSDWVRDVAWAPSIGLP 227 Q P K S D + W D E +++LE HS +V DVA + + Sbjct: 23 QTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFA 82 Query: 228 TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 287 S S D + +W + K L DV+ V++S + G DN + Sbjct: 83 VSA----SWDHSLRLWNLQNGQCQY---KFLGHTKDVL-SVAFSPDNRQIVSGGRDNALR 134 Query: 288 LWKESVDGQWVCISDVNKG 306 +W +V G+ C+ +++G Sbjct: 135 VW--NVKGE--CMHTLSRG 149 >6F3T-A nrPDB Length = 608 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/104 (33%), Positives = 58/104 (55%), Gaps = 8/104 (7%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 +AT S+DR+V+++DV NG + I GH+GP+ + ++ G LA+ + D +V++W Sbjct: 450 VATGSADRTVRLWDVLNGNCVRI--FTGHKGPIHSLTFSPN--GRFLATGATDGRVLLWD 505 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 +G E GH +V S+ ++ G ILA GS D + L Sbjct: 506 IGHGLM--VGELKGHTDTVCSLRFSRD--GEILASGSMDNTVRL 545 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 63/258 (24%), Positives = 100/258 (38%), Gaps = 39/258 (15%) Query: 32 SSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENG 91 S D +I D + ++ I L GH GPV+ +++ N L S S D V +W + Sbjct: 328 SDDVLERIMDEKTASELKI--LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQ-- 381 Query: 92 TWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTI 151 T+ + GH+ V ++P YG G D L ++ +I H Sbjct: 382 TFTCLVGYKGHNYPVWDTQFSP--YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLA 436 Query: 152 GCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAH 211 N + P NY+ A+G D ++LW + +G + H Sbjct: 437 DVNCTRFHP--------------NSNYV---ATGSADRTVRLW-DVLNGNCV--RIFTGH 476 Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS 271 + + ++P+ +A+ + DGRV +W D G M L D V + +S Sbjct: 477 KGPIHSLTFSPN----GRFLATGATDGRVLLW--DIGHGLMVGE--LKGHTDTVCSLRFS 528 Query: 272 ITANILAVSGGDNKVTLW 289 ILA DN V LW Sbjct: 529 RDGEILASGSMDNTVRLW 546 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 4/79 (5%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + T H+ IH G LAT ++D V ++D+ +G +++ +L+GH V + ++ Sbjct: 472 IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG--LMVGELKGHTDTVCSLRFSR 529 Query: 68 PMYGNILASCSYDRKVIIW 86 G ILAS S D V +W Sbjct: 530 D--GEILASGSMDNTVRLW 546 >5Y1U-A nrPDB Length = 456 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 20/128 (15%) Query: 6 NTVDTSHEDMIHDAQMD------YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 NT SH H A+++ Y LAT S+D++V ++D+RN ++ + H+ Sbjct: 292 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDE 350 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWK------------EENGTWEKTHEHSGHDSSVN 107 ++QV W+ P ILAS DR++ +W E+G E H GH + ++ Sbjct: 351 IFQVQWS-PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKIS 409 Query: 108 SVCWAPHD 115 W P++ Sbjct: 410 DFSWNPNE 417 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 16/167 (9%) Query: 7 TVDTSHEDMIHDAQ-MDYYGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGPVWQVA 64 T+ T H ++ D + + + + D+ + I+D R N + H V ++ Sbjct: 252 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 311 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 + +P ILA+ S D+ V +W N K H H + V W+PH+ ILA Sbjct: 312 F-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSG 368 Query: 125 SDGAISL--LTYTGE---------GQWEVKKINNAHTIGCNAVSWAP 160 +D +++ L+ GE G E+ I+ HT + SW P Sbjct: 369 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 415 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 108/278 (38%), Gaps = 45/278 (16%) Query: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW--------KEENGTWEKTH 97 G+I I HEG V + + P I+A+ + V+++ + +G Sbjct: 144 GKIEIEIKINHEGEVNRARYM-PQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 202 Query: 98 EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG---EGQW-EVKKINNAHTIGC 153 GH + W P+ G +L+ S D I L + EG+ + K I HT Sbjct: 203 RLRGHQKEGYGLSWNPNLSGHLLSA-SDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 261 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 VSW ++ SL F S D + +W + K ++AH+ Sbjct: 262 EDVSWH--LLHESL--------------FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTA 305 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKL-LHKF---NDVVWHVS 269 V +++ P +A+ S D V +W ++ + KL LH F D ++ V Sbjct: 306 EVNCLSFNPYSEF---ILATGSADKTVALW-------DLRNLKLKLHSFESHKDEIFQVQ 355 Query: 270 WSI-TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 WS ILA SG D ++ +W S G+ D G Sbjct: 356 WSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 393 >5FL8-q nrPDB Length = 515 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 8/125 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H+ +++ G + + S D S+K++D R+G I+ RGH V+QVAW+ Sbjct: 399 TGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGK--FISTFRGHVASVYQVAWSSDC 456 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +L SCS D + +W T + + + GH V +V W+ G + G D + Sbjct: 457 --RLLVSCSKDTTLKVWDVR--TRKLSVDLPGHKDEVYTVDWSVD--GKRVCSGGKDKMV 510 Query: 130 SLLTY 134 L T+ Sbjct: 511 RLWTH 515 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 73/284 (25%), Positives = 111/284 (39%), Gaps = 41/284 (14%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 RLA+ S D ++KI+D + ++ + GH V V W +L S S+DR V +W Sbjct: 250 RLASSSKDGTIKIWDTVS--RVCQYTMSGHTNSVSCVKWGG---QGLLYSGSHDRTVRVW 304 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV---- 142 + N + H VN + + DY L + G+ D + E Q + Sbjct: 305 -DINSQGRCINILKSHAHWVNHLSLST-DYALRI--GAFDHTGKKPSTPEEAQKKALENY 360 Query: 143 ----KKINNAHTIGCNA------VSWAPAVVPGSLIDQPSGQK-PNYI------KKFASG 185 KK N+ + A W P + QK N++ + S Sbjct: 361 EKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSA 420 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 DN IKLW + DG++ H V VAW+ L + SCS+D + +W Sbjct: 421 SFDNSIKLW-DGRDGKFIST--FRGHVASVYQVAWSSDCRL----LVSCSKDTTLKVWDV 473 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 ++ P HK D V+ V WS+ + G D V LW Sbjct: 474 RTRKLSVDLPG--HK--DEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 61/279 (21%), Positives = 117/279 (41%), Gaps = 44/279 (15%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW-----AHPMYGNILASCSY 79 G +AT S D +++++D ++G Q L LRGH + ++W P LAS S Sbjct: 198 GEVIATGSMDNTIRLWDPKSG-QCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSK 256 Query: 80 DRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ 139 D + IW + + T SGH +SV+ V W +L GS D + + +G+ Sbjct: 257 DGTIKIWDTVSRVCQYTM--SGHTNSVSCVKWGGQG---LLYSGSHDRTVRVWDINSQGR 311 Query: 140 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEED 199 ++AH + ++S A+ G+ +G+KP+ ++ +N K+ ++ + Sbjct: 312 CINILKSHAHWVNHLSLSTDYALRIGAF--DHTGKKPSTPEEAQKKALENYEKICKKNGN 369 Query: 200 GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH 259 EE + A D+ +F+W ++ + + Sbjct: 370 S---EEMMVTASDDYT------------------------MFLWNPLKSTKPI---ARMT 399 Query: 260 KFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 +V HV++S + + DN + LW + DG+++ Sbjct: 400 GHQKLVNHVAFSPDGRYIVSASFDNSIKLW-DGRDGKFI 437 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 66/152 (43%), Gaps = 36/152 (23%) Query: 100 SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCN----- 154 +GH S++ +APH ++ G+ D + W+ HT+ + Sbjct: 140 AGHGSTILCSAFAPHTSSRMVT-GAGDNTARI--------WDCDTQTPMHTLKGHYNWVL 190 Query: 155 AVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDW 214 VSW+P G +I A+G DN I+LW + + GQ + L HS W Sbjct: 191 CVSWSPD---GEVI--------------ATGSMDNTIRLW-DPKSGQCLGDA-LRGHSKW 231 Query: 215 VRDVAWAP-SIGLPTST--IASCSQDGRVFIW 243 + ++W P + P S +AS S+DG + IW Sbjct: 232 ITSLSWEPIHLVKPGSKPRLASSSKDGTIKIW 263 Score = 27.7 bits (60), Expect = 7.5, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 42/105 (40%), Gaps = 10/105 (9%) Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 + + H + A+AP +S + + + D IW CD + L Sbjct: 134 RSSSAIAGHGSTILCSAFAPHT---SSRMVTGAGDNTARIWDCDTQTPM----HTLKGHY 186 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 + V VSWS ++A DN + LW + GQ C+ D +G Sbjct: 187 NWVLCVSWSPDGEVIATGSMDNTIRLW-DPKSGQ--CLGDALRGH 228 >3JB9-L nrPDB Length = 340 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 40/126 (31%), Positives = 62/126 (49%), Gaps = 13/126 (10%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGG------QILIADLRGHEGPVWQVAW 65 H+D+I + G+ L + S D +V+IFDV+ QI + G E + VAW Sbjct: 218 HKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAW 277 Query: 66 AHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 + + + S D+ V +W + T + + GH+ SVN V + PH +IL+C SS Sbjct: 278 SRN--SRFVGAGSSDKNVYVW---SATGDLRYVLPGHEGSVNHVDFHPHQ-DIILSC-SS 330 Query: 126 DGAISL 131 D I L Sbjct: 331 DRTIFL 336 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 63/288 (21%), Positives = 110/288 (38%), Gaps = 46/288 (15%) Query: 19 AQMDYYGTRLATCSSDRSV---KIF-DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74 A+ D G+ A+ DR + +F DV+N G L G +G + + W+ ++ Sbjct: 56 ARFDPSGSYFASGGMDRQILLWNVFGDVKNYGV-----LNGCKGAITDLQWSRD--SRVV 108 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 S D ++ W +G +K +H GH VN++ +L GS LLT Sbjct: 109 YCSSSDTHLMSWDAVSG--QKIRKHKGHAGVVNALD--------VLKVGSE-----LLTS 153 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 + K+ ++ + C + I Q Q +I GG D IK+W Sbjct: 154 VSDDC--TMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQV--FI-----GGIDGAIKIW 204 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 + L+ H D + +A I S++ S S D V I+ + Sbjct: 205 DLRNN---HCSHVLKGHKDIITSLA----ISKDGSSLLSNSMDNTVRIFDVKPFASAQRQ 257 Query: 255 PKL----LHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 ++ +H + V+WS + + D V +W + D ++V Sbjct: 258 LQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYV 305 >6BX3-A nrPDB Length = 314 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 43/130 (33%), Positives = 60/130 (46%), Gaps = 8/130 (6%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 +V T+ TSH + G +AT S D SV+I + G L+ GH PV Sbjct: 44 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVIS 100 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + + GN+L + S D + IW NG+ KT S H +V SV P + IL+ Sbjct: 101 LTFNRK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSV-DVPMNDSSILSS 155 Query: 123 GSSDGAISLL 132 GS DG I + Sbjct: 156 GSYDGLIRIF 165 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 28/73 (38%), Positives = 37/73 (50%), Gaps = 5/73 (6%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY-GNILASCSYDRKV 83 G L T S D S+KI+D NG L+ + H V V+ PM +IL+S SYD + Sbjct: 107 GNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAV--VSVDVPMNDSSILSSGSYDGLI 162 Query: 84 IIWKEENGTWEKT 96 I+ E G KT Sbjct: 163 RIFDAETGHCLKT 175 >2P9P-C nrPDB Length = 372 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 4/119 (3%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85 T++A C ++ V I++ + + +L+ H G V V WA N + +C DR + Sbjct: 21 TQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD--SNRIVTCGTDRNAYV 78 Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 W + TW+ T + + V WAP++ A GS IS+ + E W V K Sbjct: 79 WTLKGRTWKPTLVILRINRAARCVRWAPNEKK--FAVGSGSRVISICYFEQENDWWVCK 135 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 69/171 (40%), Gaps = 27/171 (15%) Query: 74 LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI--SL 131 +A C + +V I+++ W + HE H+ V V WAP D I+ CG+ A +L Sbjct: 23 IAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRNAYVWTL 81 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 T + + +IN A V WAP KKFA G +I Sbjct: 82 KGRTWKPTLVILRINRA----ARCVRWAPNE-----------------KKFAVGSGSRVI 120 Query: 192 KL-WREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 + + E+E+ W + + V + W P+ L + SC R+F Sbjct: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAA--GSCDFKCRIF 169 >6EOJ-D nrPDB Length = 470 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 60/239 (25%), Positives = 101/239 (42%), Gaps = 47/239 (19%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G L +Y + +W + T+E + HDS+V ++ ++ HD +++ G +DG I Sbjct: 105 GRRLVVATYSGEFSLWNASSFTFETLMQ--AHDSAVTTMKYS-HDSDWMIS-GDADGMIK 160 Query: 131 LLTYTGEGQWE-----VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 + W+ VK+I+ AHT ++++ + KF + Sbjct: 161 I--------WQPNFSMVKEIDAAHTESIRDMAFS-----------------SNDSKFVTC 195 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 DN++K+W K+E+ L H V+ W P +GL IAS S+D V +W Sbjct: 196 SDDNILKIWNF---SNGKQERVLSGHHWDVKSCDWHPEMGL----IASASKDNLVKLW-- 246 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSIT-ANILAVSGGDNKVTLWKESVD-GQWVCISD 302 D SGN S L KF V + T N+L D ++ + +C+ D Sbjct: 247 DPRSGNCISSIL--KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 4/90 (4%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 S++ +D +H + I D ++ TCS D +KI++ NG Q + L GH V Sbjct: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVK 223 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENG 91 W HP G ++AS S D V +W +G Sbjct: 224 SCDW-HPEMG-LIASASKDNLVKLWDPRSG 251 >4PSX-B nrPDB Length = 401 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 66/140 (47%), Gaps = 14/140 (10%) Query: 12 HEDMIHDAQ-MDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D+I+D + ++ T S D +KI DVR + D P +A++H Sbjct: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQPFNTLAFSH-HS 263 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 N+LA+ D V ++ N E H SGH+ +VN++ ++ H G++++ GS + + Sbjct: 264 SNLLAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM- 321 Query: 131 LLTYTGEGQWEVKKINNAHT 150 W++K+I T Sbjct: 322 --------MWDLKQIGAEQT 333 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 14/99 (14%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 LA D V ++D+RN + L + GHE V + ++ + G +++S S D ++++W Sbjct: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 Query: 88 ------------EENGTWEKTHEHSGHDSSVNSVCWAPH 114 E+G E H+GH SSVN P Sbjct: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 >5OQL-d nrPDB Length = 446 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 72/183 (39%), Gaps = 7/183 (3%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 LA S D ++ IFD RN + L +GH V V ++ G L S SYDR + +W+ Sbjct: 255 LAVASEDHNIYIFDARNFDKALNIQ-KGHVAAVMDVEFSPT--GEELVSGSYDRTIRLWR 311 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 147 + G + H+ V W D IL GS DG + L + VK Sbjct: 312 RDAGHSRDVY-HTKRMQRVFRTMWT-MDSKYIL-TGSDDGNVRLWRANASERSGVKATRQ 368 Query: 148 AHTIGC-NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 + NA+ +P + P +KK + L + R EE+ + + Sbjct: 369 RQALEYNNALLDRYGHLPEIRRIRRHRHLPKVVKKATEIKREELAAIKRREENERKHSNK 428 Query: 207 KLE 209 K E Sbjct: 429 KYE 431 >6G51-g nrPDB Length = 317 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 81/198 (40%), Gaps = 30/198 (15%) Query: 49 LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK---EENGTWEKTHEHSGHDSS 105 L L+GH G V Q+A P + +++ S S D+ +I+WK +E GH Sbjct: 7 LRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165 V+ V + G GS DG + L W++ T G + G Sbjct: 66 VSDVVISSD--GQFALSGSWDGTLRL--------WDL-------TTGTTTRRFV-----G 103 Query: 166 SLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 D S + ++ SG D IKLW G K + E+HS+WV V ++P+ Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSS 161 Query: 226 LPTSTIASCSQDGRVFIW 243 P I SC D V +W Sbjct: 162 NP--IIVSCGWDKLVKVW 177 >5FA5-B nrPDB Length = 367 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 83/211 (39%), Gaps = 27/211 (12%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H+D++ + GT+ + S D +K++D+ Q++++ R H V VA A P Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ--QVVLSSYRAHAAQVTCVA-ASPHKD 205 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 ++ SCS D ++++W S S+ W P + G +G +SL Sbjct: 206 SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ-SEVFVFGDENGTVSL 264 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 + +++ G + ++P VP ++ S C + Sbjct: 265 VDTKSTSCVLSSAVHSQCVTG---LVFSPHSVP-------------FLASL-SEDCSLAV 307 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 D E + +AH D+VRD W+P Sbjct: 308 L------DSSLSELFRSQAHRDFVRDATWSP 332 >5WYJ-BC nrPDB Length = 817 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/121 (31%), Positives = 62/121 (51%), Gaps = 8/121 (6%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +HE I+ + + AT S D++ KI+++ NG L A L H+ +W V++ Y Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGE--LEATLANHKRGLWDVSFCQ--Y 544 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 +LA+ S D+ V IW + + KT E GH ++V + LI +CG +DG I Sbjct: 545 DKLLATSSGDKTVKIWSLDTFSVMKTLE--GHTNAVQRCSFINKQKQLI-SCG-ADGLIK 600 Query: 131 L 131 + Sbjct: 601 I 601 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 45/204 (22%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 +++ + E I ++ G L S + +KIF ++ G V + Sbjct: 52 ILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGK------------VVRSM 99 Query: 64 AWAHPMY-------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 + P Y +LA D +I+ ENG TH GH +++S+ + Y Sbjct: 100 KISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYI--THSFKGHGGTISSLKF----Y 153 Query: 117 GLI------LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQ 170 G + LA G ++G + + W++ K HT+ AV +I+ Sbjct: 154 GQLNSKIWLLASGDTNGMVKV--------WDLVKRKCLHTLQ----EHTSAVRGLDIIEV 201 Query: 171 PSGQKPNYIKKFASGGCDNLIKLW 194 P +P+ SGG D++I LW Sbjct: 202 PDNDEPSL--NLLSGGRDDIINLW 223 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 63/293 (21%), Positives = 110/293 (37%), Gaps = 46/293 (15%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKI--FDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 HED+++ G +AT S D + + ++ + + A GH V V + + Sbjct: 387 HEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIV 446 Query: 70 ---YGNILASCSYDRKVIIWKEENGTWE------KTHEHS--GHDSSVNSVCWAPHDYGL 118 Y L + S D + W T K E++ H+ +N++ +P+D Sbjct: 447 SKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS-- 504 Query: 119 ILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 I A S D + G+ E N H G VS+ Y Sbjct: 505 IFATASYDKTCKIWNLEN-GELEATLAN--HKRGLWDVSFC-----------------QY 544 Query: 179 IKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG 238 K A+ D +K+W + + + LE H++ V+ ++ + SC DG Sbjct: 545 DKLLATSSGDKTVKIWSLD---TFSVMKTLEGHTNAVQRCSFINK----QKQLISCGADG 597 Query: 239 RVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 + IW C +SG K L N+ +W +S +++ + D WK+ Sbjct: 598 LIKIWDC--SSGECL--KTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKD 646 >5L9T-R nrPDB Length = 493 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 51/99 (51%), Gaps = 4/99 (4%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 +L++ S DR + D+R L+GH V + W+ +LAS D K+++W Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH--QLLASGGNDNKLLVW 340 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 + + +++ H ++V ++ W+PH +GL+ + G + Sbjct: 341 --NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGT 377 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 11/110 (10%) Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 A G +++W + K+ LE H+ V +AW ++S S+D I Sbjct: 245 AVGTHKGFVQIW---DAAAGKKLSMLEGHTARVGALAWN------AEQLSSGSRDR--MI 293 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 D + + S + L V + WS +LA G DNK+ +W S Sbjct: 294 LQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 343 >5M25-A nrPDB Length = 434 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 92/240 (38%), Gaps = 36/240 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH V V ++ G LAS S D+ + IW +G +EKT SGH ++ V W+ Sbjct: 141 LAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWS 196 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 +L S D + + + + K ++ + CN + +V GS Sbjct: 197 SDSN--LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF----- 249 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 D +++W + K L AHSD V V + S I Sbjct: 250 ---------------DESVRIWDVKTGKCLKT---LPAHSDPVSAVHF----NRDGSLIV 287 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 S S DG IW D ASG L+ N V V +S + + DN + LW S Sbjct: 288 SSSYDGLCRIW--DTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 344 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 127/318 (39%), Gaps = 69/318 (21%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H + + G LA+ S+D+ +KI+ +G + GH+ + VAW+ Sbjct: 144 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD--S 199 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 N+L S S D+ + IW +G KT + GH + V + P ++ GS D ++ + Sbjct: 200 NLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN--LIVSGSFDESVRI 255 Query: 132 LTYTGEGQWEVK-----KINNAHTIGCNAVSWAPAVVPGSLI------------DQPSGQ 174 W+VK K AH+ +AV + GSLI D SGQ Sbjct: 256 --------WDVKTGKCLKTLPAHSDPVSAVHFNR---DGSLIVSSSYDGLCRIWDTASGQ 304 Query: 175 ----------KPNYIKKFASGG-------CDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 P KF+ G DN +KLW + G+ + + + Sbjct: 305 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW-DYSKGKCLKTYTGHKNEKYCIF 363 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKF---NDVVWHVSWSITA 274 ++ + G I S S+D V+IW N+ + +++ K DVV + T Sbjct: 364 ANFSVTGG---KWIVSGSEDNLVYIW-------NLQTKEIVQKLQGHTDVVISTACHPTE 413 Query: 275 NILAVSG--GDNKVTLWK 290 NI+A + D + LWK Sbjct: 414 NIIASAALENDKTIKLWK 431 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 32/141 (22%) Query: 170 QPSGQKPNYIKKF---------------------ASGGCDNLIKLWREEEDGQWKEEQKL 208 +P+ KPNY KF AS D LIK+W DG++ E+ + Sbjct: 127 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKF--EKTI 183 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 H + DVAW+ L + S S D + IW D +SG K L ++ V+ Sbjct: 184 SGHKLGISDVAWSSDSNL----LVSASDDKTLKIW--DVSSGKCL--KTLKGHSNYVFCC 235 Query: 269 SWSITANILAVSGGDNKVTLW 289 +++ +N++ D V +W Sbjct: 236 NFNPQSNLIVSGSFDESVRIW 256 >2H9P-A nrPDB Length = 329 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 94/240 (39%), Gaps = 36/240 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH V V ++ G LAS S D+ + IW +G +EKT SGH ++ V W+ Sbjct: 36 LAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWS 91 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 L+ A S D + + + + K ++ + CN + +V GS Sbjct: 92 SDSNLLVSA--SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF----- 144 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 D +++W + K + L AHSD V V + S I Sbjct: 145 ---------------DESVRIWDVKTG---KCLKTLPAHSDPVSAVHF----NRDGSLIV 182 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 S S DG IW D ASG L+ N V V +S + + DN + LW S Sbjct: 183 SSSYDGLCRIW--DTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 239 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 127/318 (39%), Gaps = 69/318 (21%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H + + G LA+ S+D+ +KI+ +G + GH+ + VAW+ Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD--S 94 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 N+L S S D+ + IW +G KT + GH + V + P ++ GS D ++ + Sbjct: 95 NLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN--LIVSGSFDESVRI 150 Query: 132 LTYTGEGQWEVK-----KINNAHTIGCNAVSWAPAVVPGSLI------------DQPSGQ 174 W+VK K AH+ +AV + GSLI D SGQ Sbjct: 151 --------WDVKTGKCLKTLPAHSDPVSAVHFNR---DGSLIVSSSYDGLCRIWDTASGQ 199 Query: 175 ----------KPNYIKKFASGG-------CDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 P KF+ G DN +KLW + G+ + + + Sbjct: 200 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW-DYSKGKCLKTYTGHKNEKYCIF 258 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKF---NDVVWHVSWSITA 274 ++ + G I S S+D V+IW N+ + +++ K DVV + T Sbjct: 259 ANFSVTGG---KWIVSGSEDNLVYIW-------NLQTKEIVQKLQGHTDVVISTACHPTE 308 Query: 275 NILAVSG--GDNKVTLWK 290 NI+A + D + LWK Sbjct: 309 NIIASAALENDKTIKLWK 326 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 32/141 (22%) Query: 170 QPSGQKPNYIKKF---------------------ASGGCDNLIKLWREEEDGQWKEEQKL 208 +P+ KPNY KF AS D LIK+W DG++ E+ + Sbjct: 22 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKF--EKTI 78 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 H + DVAW+ L + S S D + IW D +SG K L ++ V+ Sbjct: 79 SGHKLGISDVAWSSDSNL----LVSASDDKTLKIW--DVSSGKCL--KTLKGHSNYVFCC 130 Query: 269 SWSITANILAVSGGDNKVTLW 289 +++ +N++ D V +W Sbjct: 131 NFNPQSNLIVSGSFDESVRIW 151 >4BTS-AR nrPDB Length = 343 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 92/230 (40%), Gaps = 43/230 (18%) Query: 73 ILASCSYDRKVIIWK----EENGTWEKTHEH-SGHDSSVNSVCWAPHDYGLILACGSS-D 126 +L S S D+ V+IWK E+NG + H+ +GH+ V+ + + + A SS D Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQEN---CFAISSSWD 97 Query: 127 GAISLLTYTGEGQWEVKK-INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 + L W+++ +G + ++ A P + ++ S Sbjct: 98 KTLRL--------WDLRTGTTYKRFVGHQSEVYSVAFSPDN-------------RQILSA 136 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTST------IASCSQDGR 239 G + IKLW + ++ +K E HSDWV V ++P + AS DGR Sbjct: 137 GAEREIKLWNILGECKFSSAEK-ENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + +W N V H+S S +A G D K+ +W Sbjct: 196 LKVWNT-----NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIW 240 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 24/104 (23%), Positives = 46/104 (44%), Gaps = 4/104 (3%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H + D + + S D++++++D+R G GH+ V+ VA++ P Sbjct: 73 TGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTG--TTYKRFVGHQSEVYSVAFS-PD 129 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP 113 IL S +R++ +W + E H V+ V ++P Sbjct: 130 NRQIL-SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSP 172 >4G56-B nrPDB Length = 357 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 46/211 (21%), Positives = 81/211 (38%), Gaps = 27/211 (12%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H+D++ + GT+ + D SVK++D+ + ++ H V VA A P Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQ--KAVLKSYNAHSSEVNCVA-ACPGKD 194 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 I SC D ++++W + D+ SV W P + ACG G +SL Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHP-EKDDTFACGDETGNVSL 253 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 + + +++ + G A S+ + S+ S C + Sbjct: 254 VNIKNPDSAQTSAVHSQNITGL-AYSYHSSPFLASI----------------SEDCTVAV 296 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 D + E + +H D+V VAW+P Sbjct: 297 L------DADFSEVFRDLSHRDFVTGVAWSP 321 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 6/60 (10%) Query: 184 SGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 SGG D +K+W + K AHS V VA P + SC +DGR+ +W Sbjct: 156 SGGKDFSVKVWDLSQKAVLK---SYNAHSSEVNCVAACPG---KDTIFLSCGEDGRILLW 209 >5Y88-O nrPDB Length = 451 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 93/225 (41%), Gaps = 45/225 (20%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 +AT D +K++D+R +I + L GH+GP+ QV P+ +++S S D V +W Sbjct: 239 IATAGRDSVIKLWDMRT--RIPVITLVGHKGPINQVQCT-PVDPQVVSS-STDATVRLWD 294 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC-------GSSDGAISLLTYTGE--G 138 G K H H SV + P ++ + AC G ++G++ L + E G Sbjct: 295 VVAGKTMKVLTH--HKRSVRATALHPKEFSVASACTDDIRSWGLAEGSL-LTNFESEKTG 351 Query: 139 QWEVKKINNAHTI---GCNAV-------------SWAPAVVPGSLIDQPSGQKPNYIK-- 180 IN + G N V S A + GSL + S + K Sbjct: 352 IINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTG 411 Query: 181 -KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 + +G D IK+W+++E + E L AW P++ Sbjct: 412 LRLITGEADKSIKIWKQDETATKESEPGL----------AWNPNL 446 >6CHG-A nrPDB Length = 312 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 36/105 (34%), Positives = 50/105 (47%), Gaps = 8/105 (7%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 +A+ S D +V+I + G I L GH PV + + + GNIL S S D + W Sbjct: 69 IASGSEDFTVEITHIIYGR---IRRLMGHTAPVISICYNNK--GNILCSSSMDESIKEWH 123 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 +GT KT S H +V S+ D IL+ GS DG I + Sbjct: 124 VLSGTALKT--MSAHSDAVVSIDIPKFDSS-ILSSGSYDGLIRIF 165 >3JAP-g nrPDB Length = 326 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 74/182 (40%), Gaps = 20/182 (10%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 GN S S+D+ + +W G E GH V SV + +I A S D I Sbjct: 78 GNYAVSASWDKTLRLWNLATGNSEA--RFVGHTGDVLSVAIDANSSKIISA--SRDKTIR 133 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + G+ + + HT V V P +L D G+ + F S G D + Sbjct: 134 VWNTVGDCAYVLL----GHTDWVTKVR----VAPKNLED---GEVDDGRITFVSAGMDKI 182 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 ++ W ED ++ E H++++ V +P L AS +DG++++W S Sbjct: 183 VRSWSLNED-SYRIEADFIGHNNYINVVQPSPDGSLA----ASAGKDGQIYVWNLKHKSA 237 Query: 251 NM 252 M Sbjct: 238 FM 239 >4LG8-A nrPDB Length = 354 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/273 (24%), Positives = 112/273 (41%), Gaps = 52/273 (19%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 ++ T +D++V +FD ++ QIL A L+GH V V + HP +++ S S D + IW Sbjct: 86 KILTGGADKNVVVFD-KSSEQIL-ATLKGHTKKVTSVVF-HPSQ-DLVFSASPDATIRIW 141 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCW-APHDYGLILACGSSDGAISLLTYTGEGQWEVKKI 145 N + + H+S+V + A DY L SSD + G+ K Sbjct: 142 SVPNASCVQVVR--AHESAVTGLSLHATGDYLL----SSSDDQYWAFSDIQTGRVLTKVT 195 Query: 146 NNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEE 205 + T GC+ P LI F +G D+ IK+W +E Sbjct: 196 DE--TSGCSLT--CAQFHPDGLI-------------FGTGTMDSQIKIWDLKER------ 232 Query: 206 QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVV 265 +VA P P ++IA S++G DD+S +W + L F + Sbjct: 233 ----------TNVANFPGHSGPITSIA-FSENGYYLATAADDSSVKLWDLRKLKNFKTLQ 281 Query: 266 WHVSWSITANI-------LAVSGGDNKVTLWKE 291 ++ + + I LA+ G D ++ + K+ Sbjct: 282 LDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 314 Score = 32.3 bits (72), Expect = 0.25, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 4/68 (5%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 AQ G T + D +KI+D++ + +A+ GH GP+ +A++ Y LA+ + Sbjct: 206 AQFHPDGLIFGTGTMDSQIKIWDLKE--RTNVANFPGHSGPITSIAFSENGY--YLATAA 261 Query: 79 YDRKVIIW 86 D V +W Sbjct: 262 DDSSVKLW 269 >6EMK-B nrPDB Length = 303 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/266 (19%), Positives = 107/266 (40%), Gaps = 30/266 (11%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 +L + ++V+++D+R +A GH G V V++ + + S D + +W Sbjct: 45 KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKVW 102 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 + + + ++ H++ VN V P + G +++C DG I + GE Q ++ Sbjct: 103 DVRSPSIPRNYK---HNAPVNEVVIHP-NQGELISC-DRDGNIRIWDL-GENQC-THQLT 155 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 ++S A GS++ + + Y+ + + + K Sbjct: 156 PEDDTSLQSLSMAS---DGSMLAAANTKGNCYVWEMPN-----------HTDASHLKPVT 201 Query: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVW 266 K AHS ++ + + + +A+CS D +W+ DD + L VW Sbjct: 202 KFRAHSTYITRILLSSDV----KHLATCSADHTARVWSIDD---DFKLETTLDGHQRWVW 254 Query: 267 HVSWSITANILAVSGGDNKVTLWKES 292 ++S + L + D+ V LW S Sbjct: 255 DCAFSADSAYLVTASSDHYVRLWDLS 280 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 9/89 (10%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW-AHPMYGNILASCSYDRKVIIW 86 LATCS+D + +++ + + + L L GH+ VW A+ A Y L + S D V +W Sbjct: 222 LATCSADHTARVWSIDDDFK-LETTLDGHQRWVWDCAFSADSAY---LVTASSDHYVRLW 277 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 + T E ++ GH +VC A +D Sbjct: 278 --DLSTREIVRQYGGHHKG--AVCVALND 302 >6N9G-C nrPDB Length = 353 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 47/105 (44%), Gaps = 6/105 (5%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 ++ T S D + ++DV +G L+ GH V + A GN S D+K ++W Sbjct: 167 QILTASGDGTCALWDVESGQ--LLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 +G + E H+S VNSV + P G A GS D L Sbjct: 225 DMRSGQCVQAFE--THESDVNSVRYYPS--GDAFASGSDDATCRL 265 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 101/275 (36%), Gaps = 61/275 (22%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L+GH V + W + S S D KVI+W ++ T K H + + V + +A Sbjct: 59 LKGHGNKVLCMDWCKDK--RRIVSSSQDGKVIVW--DSFTTNKEHAVTMPCTWVMACAYA 114 Query: 113 PHDYGLILACGSSDGAISL--LTYTGEGQWEVKKINNA-HTIGCNAVSWAPA-------- 161 P G +ACG D S+ LT+ KK + A HT +A S+ + Sbjct: 115 PS--GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172 Query: 162 ---------VVPGSLIDQPSGQKPNYI----------KKFASGGCDNLIKLWREEEDGQW 202 V G L+ G + + F SGGCD +W + GQ Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW-DMRSGQC 231 Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPK-----L 257 Q E H V V + PS G F DDA+ ++ + Sbjct: 232 V--QAFETHESDVNSVRYYPS--------------GDAFASGSDDATCRLYDLRADREVA 275 Query: 258 LHKFNDVVW---HVSWSITANILAVSGGDNKVTLW 289 ++ +++ V +S++ +L D + +W Sbjct: 276 IYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVW 310 >5Z56-q nrPDB Length = 504 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 66/274 (24%), Positives = 112/274 (40%), Gaps = 54/274 (19%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 ++ T +D++V +FD ++ QIL A L+GH V V + HP +++ S S D + IW Sbjct: 236 KILTGGADKNVVVFD-KSSEQIL-ATLKGHTKKVTSVVF-HPSQ-DLVFSASPDATIRIW 291 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG--AISLLTYTGEGQWEVKK 144 N + + H+S+V + H G L S D A S + TG +V Sbjct: 292 SVPNASCVQVVR--AHESAVTGLSL--HATGDYLLSSSDDQYWAFSDIQ-TGRVLTKVTD 346 Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKE 204 + ++ C P LI F +G D+ IK+W +E Sbjct: 347 ETSGCSLTCAQFH------PDGLI-------------FGTGTMDSQIKIWDLKER----- 382 Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDV 264 +VA P P ++IA S++G DD+S +W + L F + Sbjct: 383 -----------TNVANFPGHSGPITSIA-FSENGYYLATAADDSSVKLWDLRKLKNFKTL 430 Query: 265 VWHVSWSITANI-------LAVSGGDNKVTLWKE 291 ++ + + I LA+ G D ++ + K+ Sbjct: 431 QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 464 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 34/68 (50%), Gaps = 4/68 (5%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 AQ G T + D +KI+D++ + A+ GH GP+ +A++ G LA+ + Sbjct: 356 AQFHPDGLIFGTGTMDSQIKIWDLKERTNV--ANFPGHSGPITSIAFSE--NGYYLATAA 411 Query: 79 YDRKVIIW 86 D V +W Sbjct: 412 DDSSVKLW 419 >5K1B-B nrPDB Length = 677 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 62/149 (41%), Gaps = 28/149 (18%) Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDG 200 EV+K N G NA+ PA + + + G D++I++W + Sbjct: 24 EVEKYNRN---GVNALQLDPA-----------------LNRLFTAGRDSIIRIWSVNQHK 63 Query: 201 QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK 260 Q +E H+DWV D+ + T+ S S D V +W G S HK Sbjct: 64 QDPYIASMEHHTDWVNDIVLCCN----GKTLISASSDTTVKVWNA--HKGFCMSTLRTHK 117 Query: 261 FNDVVWHVSWSITANILAVSGGDNKVTLW 289 D V ++++ ++A +G D ++ LW Sbjct: 118 --DYVKALAYAKDKELVASAGLDRQIFLW 144 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 60/127 (47%), Gaps = 13/127 (10%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H D ++D + G L + SSD +VK+++ G ++ LR H+ V +A+A Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG--FCMSTLRTHKDYVKALAYAKD--K 129 Query: 72 NILASCSYDRKVIIWKEENGT-------WEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 ++AS DR++ +W T T SG+ S+ S+ A + G I+ GS Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSL--AMNQLGTIIVSGS 187 Query: 125 SDGAISL 131 ++ + + Sbjct: 188 TEKVLRV 194 >2AQ5-A nrPDB Length = 402 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/97 (30%), Positives = 47/97 (48%), Gaps = 7/97 (7%) Query: 28 LATCSSDRSVKIFDVRNGGQIL-----IADLRGHEGPVWQVAWAHPMYGNILASCSYDRK 82 +A+ S D +V ++++ +GG +L + L GH V VAW HP N+L S D Sbjct: 97 IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW-HPTAQNVLLSAGCDNV 155 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 +++W G T H ++ SV W+ D LI Sbjct: 156 ILVWDVGTGAAVLTLGPDVHPDTIYSVDWS-RDGALI 191 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 6/74 (8%) Query: 55 GHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENG-----TWEKTHEHSGHDSSVNSV 109 GH PV +AW P N++AS S D V++W+ +G E GH V V Sbjct: 79 GHTAPVLDIAWC-PHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIV 137 Query: 110 CWAPHDYGLILACG 123 W P ++L+ G Sbjct: 138 AWHPTAQNVLLSAG 151 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 34/134 (25%), Positives = 54/134 (40%), Gaps = 10/134 (7%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEG--PVWQVAWAHPM 69 H D I+ G + T D+ V++ + R G + D R HEG PV V + Sbjct: 175 HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKD-RPHEGTRPVHAVFVSE-- 231 Query: 70 YGNILA---SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 G IL S +R+V +W ++ + + S V + P D ++ CG D Sbjct: 232 -GKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDP-DTNIVYLCGKGD 289 Query: 127 GAISLLTYTGEGQW 140 +I T E + Sbjct: 290 SSIRYFEITSEAPF 303 Score = 28.9 bits (63), Expect = 2.8, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 55/160 (34%), Gaps = 36/160 (22%) Query: 101 GHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG----QWEVKKINNAHTIGCNAV 156 GH + V + W PH+ +I A GS D + + G E HT V Sbjct: 79 GHTAPVLDIAWCPHNDNVI-ASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIV 137 Query: 157 SWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVR 216 +W P+ Q S GCDN+I +W + G + H D + Sbjct: 138 AW-----------HPTAQ-----NVLLSAGCDNVILVW-DVGTGAAVLTLGPDVHPDTIY 180 Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPK 256 V W S+DG + +C D + P+ Sbjct: 181 SVDW--------------SRDGALICTSCRDKRVRVIEPR 206 >3C9C-A nrPDB Length = 432 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 65/278 (23%), Positives = 106/278 (38%), Gaps = 45/278 (16%) Query: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW--------KEENGTWEKTH 97 G+I I HEG V + + P ++A+ + V+++ E +G + Sbjct: 119 GKIEIEIKINHEGEVNRARYM-PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 177 Query: 98 EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL----LTYTGEGQWEVKKINNAHTIGC 153 GH + W P+ G +L+ S D I L T + K I HT Sbjct: 178 RLRGHQKEGYGLSWNPNLNGYLLS-ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVV 236 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 V+W ++ SL F S D + +W + K ++AH+ Sbjct: 237 EDVAWH--LLHESL--------------FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA 280 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKL-LHKF---NDVVWHVS 269 V +++ P +A+ S D V +W ++ + KL LH F D ++ V Sbjct: 281 EVNCLSFNPYSEF---ILATGSADKTVALW-------DLRNLKLKLHSFESHKDEIFQVQ 330 Query: 270 WSI-TANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 WS ILA SG D ++ +W S G+ D G Sbjct: 331 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 368 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 62/145 (42%), Gaps = 15/145 (10%) Query: 28 LATCSSDRSVKIFDVRNGGQILIAD-LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 + + D+ + I+D RN + + H V +++ +P ILA+ S D+ V +W Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF-NPYSEFILATGSADKTVALW 307 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL--LTYTGE------- 137 N K H H + V W+PH+ ILA +D + + L+ GE Sbjct: 308 DLRNLKL-KLHSFESHKDEIFQVQWSPHN-ETILASSGTDRRLHVWDLSKIGEEQSTEDA 365 Query: 138 --GQWEVKKINNAHTIGCNAVSWAP 160 G E+ I+ HT + SW P Sbjct: 366 EDGPPELLFIHGGHTAKISDFSWNP 390 >4AEZ-A nrPDB Length = 401 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/116 (28%), Positives = 54/116 (46%), Gaps = 8/116 (6%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASC--SYDRK 82 G +LA+ +D V+I+D R+ I H V VAW P N+LA+ + D++ Sbjct: 229 GLQLASGGNDNVVQIWDARS--SIPKFTKTNHNAAVKAVAWC-PWQSNLLATGGGTMDKQ 285 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 + W G T + S V S+ W+PH ++ G D +S+ +Y+ G Sbjct: 286 IHFWNAATGARVNTVDAG---SQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSG 338 >5MZH-A nrPDB Length = 452 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 6/105 (5%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 +V H D + D D GT++ + S+D S +++ G + L GHEG + +VA+ Sbjct: 299 SVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTG--VCQHTLVGHEGEISKVAF- 355 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 +P G L + S D+ +W + G + E GH + S + Sbjct: 356 NPQ-GTRLITASSDKTCRLWDCDTGECLQVLE--GHTDEIFSCAF 397 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 8/124 (6%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 V + H + Q +Y GT + + S D + +++DVR+G + + +GH V VA+ Sbjct: 258 VLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVK--QGHTDEVLDVAF-- 313 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 G + S S D ++ G + H GH+ ++ V + P LI A SSD Sbjct: 314 DAAGTKMVSASADGSARLYHTLTGVCQ--HTLVGHEGEISKVAFNPQGTRLITA--SSDK 369 Query: 128 AISL 131 L Sbjct: 370 TCRL 373 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 57/271 (21%), Positives = 102/271 (37%), Gaps = 51/271 (18%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVII 85 T +AT S D + K++DV G + A L GH + V+ G+++ + S+D + Sbjct: 192 TIIATGSMDNTAKLWDVETGQE--RATLAGHRAEI--VSLGFNTGGDLIVTGSFDHDSRL 247 Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDY-GLILACGSSDGAISLLTYTGEGQWEVK- 143 W G + H SGH V+S + +Y G ++ GS D L W+V+ Sbjct: 248 WDVRTG--QCVHVLSGHRGEVSSTQF---NYAGTLVVSGSIDCTSRL--------WDVRS 294 Query: 144 ----KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEED 199 + HT V++ A G+ + S + +G C Sbjct: 295 GRCLSVKQGHTDEVLDVAFDAA---GTKMVSASADGSARLYHTLTGVC------------ 339 Query: 200 GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH 259 + L H + VA+ P + + + S D +W CD ++L Sbjct: 340 -----QHTLVGHEGEISKVAFNPQ----GTRLITASSDKTCRLWDCDTGE----CLQVLE 386 Query: 260 KFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 D ++ +++ + + DN +WK Sbjct: 387 GHTDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 38/76 (50%), Gaps = 4/76 (5%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 HE I + GTRL T SSD++ +++D G + + L GH ++ A+ + G Sbjct: 346 HEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQV--LEGHTDEIFSCAFNYE--G 401 Query: 72 NILASCSYDRKVIIWK 87 + + + S D IWK Sbjct: 402 DFIITGSKDNTCRIWK 417 Score = 34.3 bits (77), Expect = 0.070, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 70/175 (40%), Gaps = 30/175 (17%) Query: 38 KIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTH 97 K+ + ++ L LR H P+ A+ G+ + SYDR +W G E+ Sbjct: 75 KMLEQQHHSFTLFKVLRAHILPLTNCAFNKS--GDRFITGSYDRTCKVWNTFTG--EEVF 130 Query: 98 EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL-LTYTGEGQWEVKKINNAHTIGCNAV 156 GH + V ++ + + YG + GS D L YTG+ + +K H + Sbjct: 131 TLEGHKNVVYAIAFN-NPYGDKIVTGSFDKTCKLWDAYTGQLYYTLK----GHQTEIVCL 185 Query: 157 SWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAH 211 S+ P ++I A+G DN KLW + E GQ E L H Sbjct: 186 SFNPQ---STII--------------ATGSMDNTAKLW-DVETGQ--ERATLAGH 220 >3DM0-A nrPDB Length = 694 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 100/256 (39%), Gaps = 50/256 (19%) Query: 46 GQILIADLRGHEGPVWQVAWAHPM-YGNILASCSYDRKVIIWK---EENGTWEKTHEHSG 101 G +L +R H V A A P+ +I+ S S D+ +I+WK ++ +G Sbjct: 371 GLVLKGTMRAHTDMV--TAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTG 428 Query: 102 HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV-----KKINNAHTIGCNAV 156 H V V + G GS DG + L W++ + HT +V Sbjct: 429 HSHFVEDVVLSSD--GQFALSGSWDGELRL--------WDLAAGVSTRRFVGHTKDVLSV 478 Query: 157 SWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVR 216 +++ +D ++ S D IKLW + ++ + E H DWV Sbjct: 479 AFS--------LDN---------RQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVS 521 Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKL---LHKFNDVVWHVSWSIT 273 V ++P+ P TI S S D V +W N+ + KL L V V+ S Sbjct: 522 CVRFSPNTLQP--TIVSASWDKTVKVW-------NLSNCKLRSTLAGHTGYVSTVAVSPD 572 Query: 274 ANILAVSGGDNKVTLW 289 ++ A G D V LW Sbjct: 573 GSLCASGGKDGVVLLW 588 >3ODT-A nrPDB Length = 313 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 8/94 (8%) Query: 4 VINTVDTSHEDMI-HDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 VI T H D++ H A +D +CS+D +K+ D+ G ++ GHE V+ Sbjct: 175 VIKTFSGIHNDVVRHLAVVD--DGHFISCSNDGLIKLVDMHTGD--VLRTYEGHESFVYC 230 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKT 96 + + + SC DR V IW +ENG+ ++ Sbjct: 231 IKL---LPNGDIVSCGEDRTVRIWSKENGSLKQV 261 >3W15-A nrPDB Length = 368 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 59/270 (21%), Positives = 96/270 (35%), Gaps = 71/270 (26%) Query: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 + SHE+ + AQ D ++++FD + IA + HE V+ W Sbjct: 71 NESHENQVLVAQ------------GDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLV 117 Query: 69 MYGNILASCSYDRKVIIWKEE----------------------NGTWEKTHEHSGHDSSV 106 N L+S S+D + IW N K +G + Sbjct: 118 NRQNFLSS-SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 176 Query: 107 NSVC---WAPHDYGLILACGSSDGA--ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPA 161 N V ++PHD L+L+C + A + +G+ Q + + C+ + P Sbjct: 177 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY 236 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW----REEEDGQWKEEQKL----EAHSD 213 VV A+GG DN I++W + GQ + AH Sbjct: 237 VV-------------------ATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 +R V W+P ++ + S S D IW Sbjct: 278 AIRKVTWSPH---HSNILMSASYDMTCRIW 304 Score = 33.9 bits (76), Expect = 0.097, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 51/97 (52%), Gaps = 11/97 (11%) Query: 23 YYGTRLATCSSDRSVKIFDVR----NGGQI----LIADL-RGHEGPVWQVAWAHPMYGNI 73 Y +AT D +++I+D+R N GQ+ I ++ H + +V W+ P + NI Sbjct: 233 YRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWS-PHHSNI 291 Query: 74 LASCSYDRKVIIWKE-ENGTWEKTHEHSGHDSSVNSV 109 L S SYD IW++ N ++T++ + D++ S+ Sbjct: 292 LMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 328 >6QX9-4B nrPDB Length = 522 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 8/107 (7%) Query: 21 MDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYD 80 +D LA+C++D SVK++ + + +AD+ GH V +V W HP G L + YD Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEP--VADIEGHTVRVARVMW-HPS-GRFLGTTCYD 344 Query: 81 RKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 R +W E E+ GH V + + H G + G D Sbjct: 345 RSWRLWDLE--AQEEILHQEGHSMGVYDIAF--HQDGSLAGTGGLDA 387 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 5/95 (5%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H I+ G +AT S D + K++D+R + + + H+ V V + P++G Sbjct: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ--RRCVYTIPAHQNLVTGVKF-EPIHG 462 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSV 106 N L + +YD IW W +GH+ V Sbjct: 463 NFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKV 495 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 23/80 (28%), Positives = 42/80 (52%), Gaps = 5/80 (6%) Query: 11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 +H++++ + + +G L T + D + KI+ + G + L GHEG V + + Sbjct: 447 AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT--HPGWSPLKTLAGHEGKVMGLDISSD- 503 Query: 70 YGNILASCSYDRKVIIWKEE 89 G ++A+CSYDR +W E Sbjct: 504 -GQLIATCSYDRTFKLWMAE 522 >5OPT-p nrPDB Length = 318 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%) Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 ++ SGG DN +++W + G+ AH+DWV V ++PS L T I S D Sbjct: 122 RQIVSGGRDNALRVWNVK--GECLHTLGRGAHTDWVSCVRFSPS--LETPLIVSGGWDNL 177 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 V +W D ASG + + L + + V+ S ++ A S D LW Sbjct: 178 VKVW--DIASGRLLTD--LKGHTNYITSVTVSPDGSLCASSDKDGVARLW 223 >5FVM-C nrPDB Length = 303 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 53/261 (20%), Positives = 104/261 (39%), Gaps = 40/261 (15%) Query: 37 VKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKT 96 V+++D+R+ ++ GH+G V +A+ + S S D + +W + + ++ Sbjct: 55 VRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQE--NRWMVSSSEDGTIKVWDVRSPSVQRN 112 Query: 97 HEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW--EVKKINNAHTIGCN 154 ++ H++ VN V P + G +++C DG I + GE Q ++ +N + Sbjct: 113 YK---HNAPVNEVAIHP-NQGELISC-DQDGNIRIWDL-GENQCTNQLTPEDNTPLQSLS 166 Query: 155 AVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR---EEEDGQWKEEQKLEAH 211 S +V G+ G C +WR + + K ++H Sbjct: 167 VASDGSMLVAGN----------------NKGNC----YVWRMPHHTDASTLEPVTKFKSH 206 Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS 271 + ++ V + + +A+CS D +W +D N L VW ++S Sbjct: 207 TKYITRVLLSADV----KNLATCSADHTARVWNIED---NYQLETTLDGHQRWVWDCAFS 259 Query: 272 ITANILAVSGGDNKVTLWKES 292 + L + D+ V LW S Sbjct: 260 ADSAYLVTACSDHYVRLWDLS 280 Score = 32.3 bits (72), Expect = 0.26, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 9/106 (8%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW-AHPM 69 SH I + LATCS+D + +++++ + Q L L GH+ VW A+ A Sbjct: 205 SHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQ-LETTLDGHQRWVWDCAFSADSA 263 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 Y ++ +CS D V +W + T E ++ GH +VC A +D Sbjct: 264 Y--LVTACS-DHYVRLW--DLSTSEIVRQYGGHHKG--AVCVALND 302 Score = 28.1 bits (61), Expect = 4.7, Method: Compositional matrix adjust. Identities = 49/218 (22%), Positives = 84/218 (38%), Gaps = 34/218 (15%) Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ILAS YD + W+ G +T +H+ DS VN L S ++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHA--DSQVNR-----------LEITSDKKYLAAA 50 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + ++++ N N VS G++ Q+ ++ S D IK Sbjct: 51 GHLHVRLYDIRSNNP------NPVSSFEG-HKGNVTSIAFQQENRWM---VSSSEDGTIK 100 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 +W D + Q+ H+ V +VA P+ G + SC QDG + IW D N Sbjct: 101 VW----DVRSPSVQRNYKHNAPVNEVAIHPNQG----ELISCDQDGNIRIW---DLGENQ 149 Query: 253 WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + +L + N + +S + ++L +W+ Sbjct: 150 CTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWR 187 >3CFV-B nrPDB Length = 414 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 15/149 (10%) Query: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRK 82 + + + + D+ + I+D R+ + L H V +++ +P ILA+ S D+ Sbjct: 241 HESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSF-NPYSEFILATGSADKT 299 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL--LTYTGE--- 137 V +W N K H H + V W+PH+ ILA +D +++ L+ GE Sbjct: 300 VALWDLRNLKL-KLHTFESHKDEIFQVHWSPHN-ETILASSGTDRRLNVWDLSKIGEEQS 357 Query: 138 ------GQWEVKKINNAHTIGCNAVSWAP 160 G E+ I+ HT + SW P Sbjct: 358 AEDAEDGPPELLFIHGGHTAKISDFSWNP 386 Score = 34.7 bits (78), Expect = 0.056, Method: Compositional matrix adjust. Identities = 43/196 (21%), Positives = 75/196 (38%), Gaps = 28/196 (14%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW-----KEENGTWEKTHEHSGHDSSVN 107 LRGH+ + ++W + G++L S S D V +W +E + +GH + V Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVE 233 Query: 108 SVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSL 167 V W L + D + + + + +AHT N +S+ P Sbjct: 234 DVAWHLLHESL-FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPY------ 286 Query: 168 IDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP 227 +I A+G D + LW + + E+H D + V W+P Sbjct: 287 --------SEFI--LATGSADKTVALW--DLRNLKLKLHTFESHKDEIFQVHWSPH---N 331 Query: 228 TSTIASCSQDGRVFIW 243 + +AS D R+ +W Sbjct: 332 ETILASSGTDRRLNVW 347 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 55/130 (42%), Gaps = 15/130 (11%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 F S D + +W + K ++AH+ V +++ P +A+ S D V Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF---ILATGSADKTVA 301 Query: 242 IWTCDDASGNMWSPKL-LHKF---NDVVWHVSWSI-TANILAVSGGDNKVTLWKESVDGQ 296 +W ++ + KL LH F D ++ V WS ILA SG D ++ +W S G+ Sbjct: 302 LW-------DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGE 354 Query: 297 WVCISDVNKG 306 D G Sbjct: 355 EQSAEDAEDG 364 >4V7E-Bg nrPDB Length = 380 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 7/120 (5%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLR---GHEGPVWQVAWAHPMYGNILASCSYDRK 82 TRL T S D++ ++DV G +I I GH V ++ + + N+ S S D Sbjct: 171 TRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLS-INSLNANMFISGSCDTT 229 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 V +W + T + GH+ +NSV + P G GS DG L Q +V Sbjct: 230 VRLW-DLRITSRAVRTYHGHEGDINSVKFFPD--GQRFGTGSDDGTCRLFDMRTGHQLQV 286 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 42/98 (42%), Gaps = 12/98 (12%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI----ADLRGHEGPVWQVAWAH 67 HE I+ + G R T S D + ++FD+R G Q+ + D +E P+ + A Sbjct: 248 HEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPI-VTSVAF 306 Query: 68 PMYGNILASCSYDRKVIIWKE-------ENGTWEKTHE 98 + G +L + + +W GT + +HE Sbjct: 307 SISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHE 344 >5UZ7-B nrPDB Length = 351 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 95/270 (35%), Gaps = 56/270 (20%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 LRGH ++ + W +L S S D K+IIW ++ T K H S V + +A Sbjct: 62 LRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIW--DSYTTNKVHAIPLRSSWVMTCAYA 117 Query: 113 PHDYGLILACGSSDGAISLLTY-TGEGQWEVKKINNAHT--IGCNAVSWAPAVVPGS--- 166 P G +ACG D S+ T EG V + HT + C +V S Sbjct: 118 PS--GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 175 Query: 167 -------------------LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQK 207 D S + F SG CD KLW E G + Q Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVRE-GMCR--QT 232 Query: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPK-----LLHKFN 262 H + + + P +G F DDA+ ++ + + + + Sbjct: 233 FTGHESDINAICFFP--------------NGNAFATGSDDATCRLFDLRADQELMTYSHD 278 Query: 263 DVVW---HVSWSITANILAVSGGDNKVTLW 289 +++ VS+S + +L D +W Sbjct: 279 NIICGITSVSFSKSGRLLLAGYDDFNCNVW 308 Score = 27.3 bits (59), Expect = 9.4, Method: Compositional matrix adjust. Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 8/123 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV-AWAHP 68 T HE I+ G AT S D + ++FD+R +++ H+ + + + + Sbjct: 234 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY---SHDNIICGITSVSFS 290 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 G +L + D +W ++ +GHD+ V+ C D G+ +A GS D Sbjct: 291 KSGRLLLAGYDDFNCNVWDALKA--DRAGVLAGHDNRVS--CLGVTDDGMAVATGSWDSF 346 Query: 129 ISL 131 + + Sbjct: 347 LKI 349 >2YNP-A nrPDB Length = 604 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 14/86 (16%) Query: 176 PNYIKKFA---------SGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 P+YI+ A SG D +KLW E + W EQ E H +V VA+ P Sbjct: 97 PDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN--WALEQTFEGHEHFVMCVAFNPK--- 151 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNM 252 ST AS D V +W+ ++ N Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNF 177 >4N14-A nrPDB Length = 314 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 86/224 (38%), Gaps = 40/224 (17%) Query: 11 SHEDMIHDA---QMDYY--------GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 S D I DA + DYY G LA + D SV ++ +G + + + Sbjct: 7 SLPDRILDAPEIRNDYYLNLVDWSSGNVLAV-ALDNSVYLWSASSGDILQLLQMEQPGEY 65 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 + VAW GN LA + +V +W + ++ + H + V S+ W + I Sbjct: 66 ISSVAWIKE--GNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNSY----I 117 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 L+ GS G I + V ++ H+ + WAP Sbjct: 118 LSSGSRSGHIHHHDVR-VAEHHVATLS-GHSQEVCGLRWAPDG----------------- 158 Query: 180 KKFASGGCDNLIKLWREEE-DGQWKEEQKLEAHSDWVRDVAWAP 222 + ASGG DNL+ +W +G W Q H V+ VAW P Sbjct: 159 RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 202 Score = 34.7 bits (78), Expect = 0.063, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 67/175 (38%), Gaps = 28/175 (16%) Query: 25 GTRLATCSSDRSVKIFDVR--NGGQILIADLRGHEGPVWQVAWAHPMYGNILAS--CSYD 80 G LA+ +D V ++ GG + + H+G V VAW P N+LA+ + D Sbjct: 158 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC-PWQSNVLATGGGTSD 216 Query: 81 RKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW 140 R + IW +G + S V S+ W+PH LI G + + + Y + Sbjct: 217 RHIRIWNVCSGACLSAVD---AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 273 Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR 195 K + + + SL P G AS D ++LWR Sbjct: 274 AELKGHTSRVL--------------SLTMSPDG------ATVASAAADETLRLWR 308 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 75/201 (37%), Gaps = 35/201 (17%) Query: 50 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE--NGTWEKTHEHSGHDSSVN 107 +A L GH V + WA G LAS D V +W G W + H +V Sbjct: 139 VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 196 Query: 108 SVCWAP-HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 +V W P L G+SD I + +AH+ C ++ W+P Sbjct: 197 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA---CLSAVDAHSQVC-SILWSP------ 246 Query: 167 LIDQPSGQKPNYIKKFASGG--CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 + K+ SG N + +W+ + E L+ H+ V + +P Sbjct: 247 -----------HYKELISGHGFAQNQLVIWKYPTMAKVAE---LKGHTSRVLSLTMSPD- 291 Query: 225 GLPTSTIASCSQDGRVFIWTC 245 +T+AS + D + +W C Sbjct: 292 ---GATVASAAADETLRLWRC 309 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 55/132 (41%), Gaps = 13/132 (9%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 A G ++LW + Q K + + +HS V ++W I ++S S+ G + Sbjct: 78 LAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSYI------LSSGSRSGHIH 128 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV-DGQWVCI 300 A ++ L + V + W+ LA G DN V +W + +G WV + Sbjct: 129 HHDVRVAEHHV---ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 185 Query: 301 SDVNKGQGSVSA 312 + QG+V A Sbjct: 186 QTFTQHQGAVKA 197 >5N4A-A nrPDB Length = 771 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 8/97 (8%) Query: 23 YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRK 82 Y GT LAT D SVKI+ RNG +L + L + PV+ + WA+ + L C+ Sbjct: 114 YDGTALATAGEDGSVKIWS-RNG--MLRSTLAQADSPVYSIVWAYDC--DQLCYCTGSNV 168 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 VI N K + HD V V W+P ++ +I Sbjct: 169 VIKSLSSNA---KQNAWKAHDGVVLKVDWSPINHLII 202 Score = 27.7 bits (60), Expect = 6.1, Method: Compositional matrix adjust. Identities = 48/225 (21%), Positives = 80/225 (35%), Gaps = 44/225 (19%) Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGL-------ILACGS 124 N L +CS D+ + W N E + S D+ + W P + A Sbjct: 26 NELFTCSDDQTIHKW---NMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVAC 82 Query: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFAS 184 +DG++ +L+ TG V+K H C ++ W+ G+ + A+ Sbjct: 83 TDGSVKILSRTGR----VEKSIEGHKGACISLRWS---YDGTAL--------------AT 121 Query: 185 GGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 G D +K+W +G + L V + WA + C+ V Sbjct: 122 AGEDGSVKIW--SRNGMLRS--TLAQADSPVYSIVWA----YDCDQLCYCTGSNVVIKSL 173 Query: 245 CDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 +A N W + VV V WS +++ G D K +W Sbjct: 174 SSNAKQNAWKAH-----DGVVLKVDWSPINHLIITGGEDCKYKVW 213 >5GAN-H nrPDB Length = 465 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 45/95 (47%), Gaps = 2/95 (2%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G ++AT D + ++D+R + + + H V QV ++ G L SC YD + Sbjct: 361 GYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLIN 420 Query: 85 IWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 ++ + TW K +GH + S+ + + + L+ Sbjct: 421 VYSSD--TWLKMGSLAGHTDKIISLDISNNSHFLV 453 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 84/209 (40%), Gaps = 34/209 (16%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 HE I D + G + + S D + +++D ++L+ + GH+ V+ +++ G Sbjct: 264 HERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQE--GHDKGVFSLSFQCD--G 319 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 +++ S D ++W +G+ K +GH + +V W+P+ Y + A G DG I++ Sbjct: 320 SLVCSGGMDSLSMLWDIRSGS--KVMTLAGHSKPIYTVAWSPNGYQV--ATGGGDGIINV 375 Query: 132 --LTYTGEGQWE--------------VKKINNAHTIGC------NAVSWAPAVVPGSLID 169 + EGQ K+ + C N S + GSL Sbjct: 376 WDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAG 435 Query: 170 QP----SGQKPNYIKKFASGGCDNLIKLW 194 S N SGG D IKLW Sbjct: 436 HTDKIISLDISNNSHFLVSGGWDRSIKLW 464 >3MKQ-A nrPDB Length = 814 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 14/86 (16%) Query: 176 PNYIKKFA---------SGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 P+YI+ A SG D +KLW E + W EQ E H +V VA+ P Sbjct: 97 PDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN--WALEQTFEGHEHFVMCVAFNPK--- 151 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNM 252 ST AS D V +W+ ++ N Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNF 177 >5LCW-Q nrPDB Length = 374 Score = 35.8 bits (81), Expect = 0.023, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 75/192 (39%), Gaps = 30/192 (15%) Query: 25 GTRLATCSSDRSVKIFDVR--NGGQILIADLRGHEGPVWQVAWAHPMYGNILAS--CSYD 80 G LA+ +D V ++ GG + + H+G V VAW P N+LA+ + D Sbjct: 196 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC-PWQSNVLATGGGTSD 254 Query: 81 RKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW 140 R + IW +G + S V S+ W+PH LI G + + + Y + Sbjct: 255 RHIRIWNVCSGACLSAVD---AHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 311 Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR--EEE 198 K + + + SL P G AS D ++LWR E + Sbjct: 312 AELKGHTSRVL--------------SLTMSPDG------ATVASAAADETLRLWRCFELD 351 Query: 199 DGQWKEEQKLEA 210 + +E +K A Sbjct: 352 PARRREREKASA 363 Score = 35.4 bits (80), Expect = 0.030, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 55/189 (29%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 GN+LA + D V +W +G + + ++SV W G LA G+S + Sbjct: 70 GNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE--GNYLAVGTSSAEVQ 126 Query: 131 LLTYTGEGQWEV---KKINN--AHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI------ 179 L W+V K++ N +H+ ++SW ++ SG + +I Sbjct: 127 L--------WDVQQQKRLRNMTSHSARVGSLSWNSYILS-------SGSRSGHIHHHDVR 171 Query: 180 -------------------------KKFASGGCDNLIKLWREEE-DGQWKEEQKLEAHSD 213 + ASGG DNL+ +W +G W Q H Sbjct: 172 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 231 Query: 214 WVRDVAWAP 222 V+ VAW P Sbjct: 232 AVKAVAWCP 240 Score = 31.2 bits (69), Expect = 0.59, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 77/206 (37%), Gaps = 45/206 (21%) Query: 50 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE--NGTWEKTHEHSGHDSSVN 107 +A L GH V + WA G LAS D V +W G W + H +V Sbjct: 177 VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 234 Query: 108 SVCWAP-HDYGLILACGSSDGAISLLTYTGEGQWEV-----KKINNAHTIGCNAVSWAPA 161 +V W P L G+SD I + W V +AH+ C ++ W+P Sbjct: 235 AVAWCPWQSNVLATGGGTSDRHIRI--------WNVCSGACLSAVDAHSQVC-SILWSP- 284 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGG--CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 + K+ SG N + +W+ + E L+ H+ V + Sbjct: 285 ----------------HYKELISGHGFAQNQLVIWKYPTMAKVAE---LKGHTSRVLSLT 325 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTC 245 +P +T+AS + D + +W C Sbjct: 326 MSPD----GATVASAAADETLRLWRC 347 Score = 28.5 bits (62), Expect = 3.8, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 13/132 (9%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 A G ++LW + Q K + + +HS V ++W I ++S S+ G + Sbjct: 116 LAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSYI------LSSGSRSGHIH 166 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV-DGQWVCI 300 A ++ + L + V + W+ LA G DN V +W + +G WV + Sbjct: 167 HHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 223 Query: 301 SDVNKGQGSVSA 312 + QG+V A Sbjct: 224 QTFTQHQGAVKA 235 >4GGA-A nrPDB Length = 420 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 75/193 (38%), Gaps = 32/193 (16%) Query: 25 GTRLATCSSDRSVKIFDVR--NGGQILIADLRGHEGPVWQVAWAHPMYGNILAS--CSYD 80 G LA+ +D V ++ GG + + H+G V VAW P N+LA+ + D Sbjct: 242 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC-PWQSNVLATGGGTSD 300 Query: 81 RKVIIWKEENGT-WEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ 139 R + IW +G H S V S+ W+PH LI G + + + Y + Sbjct: 301 RHIRIWNVCSGACLSAVDAH----SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 356 Query: 140 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR--EE 197 K + + + SL P G AS D ++LWR E Sbjct: 357 VAELKGHTSRVL--------------SLTMSPDG------ATVASAAADETLRLWRCFEL 396 Query: 198 EDGQWKEEQKLEA 210 + + +E +K A Sbjct: 397 DPARRREREKASA 409 Score = 35.4 bits (80), Expect = 0.037, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 55/189 (29%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 GN+LA + D V +W +G + + ++SV W G LA G+S + Sbjct: 116 GNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE--GNYLAVGTSSAEVQ 172 Query: 131 LLTYTGEGQWEV---KKINN--AHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI------ 179 L W+V K++ N +H+ ++SW ++ SG + +I Sbjct: 173 L--------WDVQQQKRLRNMTSHSARVGSLSWNSYILS-------SGSRSGHIHHHDVR 217 Query: 180 -------------------------KKFASGGCDNLIKLWREEE-DGQWKEEQKLEAHSD 213 + ASGG DNL+ +W +G W Q H Sbjct: 218 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 277 Query: 214 WVRDVAWAP 222 V+ VAW P Sbjct: 278 AVKAVAWCP 286 Score = 31.2 bits (69), Expect = 0.58, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 77/206 (37%), Gaps = 45/206 (21%) Query: 50 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE--NGTWEKTHEHSGHDSSVN 107 +A L GH V + WA G LAS D V +W G W + H +V Sbjct: 223 VATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 280 Query: 108 SVCWAP-HDYGLILACGSSDGAISLLTYTGEGQWEV-----KKINNAHTIGCNAVSWAPA 161 +V W P L G+SD I + W V +AH+ C ++ W+P Sbjct: 281 AVAWCPWQSNVLATGGGTSDRHIRI--------WNVCSGACLSAVDAHSQVC-SILWSP- 330 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGG--CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 + K+ SG N + +W+ + E L+ H+ V + Sbjct: 331 ----------------HYKELISGHGFAQNQLVIWKYPTMAKVAE---LKGHTSRVLSLT 371 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTC 245 +P +T+AS + D + +W C Sbjct: 372 MSPD----GATVASAAADETLRLWRC 393 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 56/132 (42%), Gaps = 13/132 (9%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 A G ++LW + Q K + + +HS V ++W I ++S S+ G + Sbjct: 162 LAVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSYI------LSSGSRSGHIH 212 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV-DGQWVCI 300 A ++ + L + V + W+ LA G DN V +W + +G WV + Sbjct: 213 HHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPL 269 Query: 301 SDVNKGQGSVSA 312 + QG+V A Sbjct: 270 QTFTQHQGAVKA 281 >5G04-R nrPDB Length = 499 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 75/193 (38%), Gaps = 32/193 (16%) Query: 25 GTRLATCSSDRSVKIFDVR--NGGQILIADLRGHEGPVWQVAWAHPMYGNILAS--CSYD 80 G LA+ +D V ++ GG + + H+G V VAW P N+LA+ + D Sbjct: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC-PWQSNVLATGGGTSD 379 Query: 81 RKVIIWKEENGT-WEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ 139 R + IW +G H S V S+ W+PH LI G + + + Y + Sbjct: 380 RHIRIWNVCSGACLSAVDAH----SQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAK 435 Query: 140 WEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR--EE 197 K + + + SL P G AS D ++LWR E Sbjct: 436 VAELKGHTSRVL--------------SLTMSPDG------ATVASAAADETLRLWRCFEL 475 Query: 198 EDGQWKEEQKLEA 210 + + +E +K A Sbjct: 476 DPARRREREKASA 488 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 55/189 (29%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 GN+LA + D V +W +G + + ++SV W G LA G+S + Sbjct: 195 GNVLA-VALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI--KEGNYLAVGTSSAEVQ 251 Query: 131 LLTYTGEGQWEV---KKINN--AHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI------ 179 L W+V K++ N +H+ ++SW ++ SG + +I Sbjct: 252 L--------WDVQQQKRLRNMTSHSARVGSLSWNSYILS-------SGSRSGHIHHHDVR 296 Query: 180 -------------------------KKFASGGCDNLIKLWREEE-DGQWKEEQKLEAHSD 213 + ASGG DNL+ +W +G W Q H Sbjct: 297 VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG 356 Query: 214 WVRDVAWAP 222 V+ VAW P Sbjct: 357 AVKAVAWCP 365 Score = 31.2 bits (69), Expect = 0.62, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 77/206 (37%), Gaps = 45/206 (21%) Query: 50 IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE--NGTWEKTHEHSGHDSSVN 107 +A L GH V + WA G LAS D V +W G W + H +V Sbjct: 302 VATLSGHSQEVCGLRWA--PDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 359 Query: 108 SVCWAP-HDYGLILACGSSDGAISLLTYTGEGQWEV-----KKINNAHTIGCNAVSWAPA 161 +V W P L G+SD I + W V +AH+ C ++ W+P Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRI--------WNVCSGACLSAVDAHSQVC-SILWSP- 409 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGG--CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 + K+ SG N + +W+ + E L+ H+ V + Sbjct: 410 ----------------HYKELISGHGFAQNQLVIWKYPTMAKVAE---LKGHTSRVLSLT 450 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTC 245 +P +T+AS + D + +W C Sbjct: 451 MSPD----GATVASAAADETLRLWRC 472 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 16/137 (11%) Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 NY+ A G ++LW + Q K + + +HS V ++W I ++S S+ Sbjct: 239 NYL---AVGTSSAEVQLWDVQ---QQKRLRNMTSHSARVGSLSWNSYI------LSSGSR 286 Query: 237 DGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV-DG 295 G + A ++ + L + V + W+ LA G DN V +W + +G Sbjct: 287 SGHIHHHDVRVAEHHVAT---LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEG 343 Query: 296 QWVCISDVNKGQGSVSA 312 WV + + QG+V A Sbjct: 344 GWVPLQTFTQHQGAVKA 360 >4XFV-A nrPDB Length = 792 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 25/111 (22%), Positives = 50/111 (45%), Gaps = 21/111 (18%) Query: 44 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE-----NGTWEKTHE 98 N ++ + + H +W WA +GN+ + S D+ V +W+ + + E + + Sbjct: 644 NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK 703 Query: 99 H-------SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 H S HDS + ++++ G +G I L +YT G++E+ Sbjct: 704 HTKAVTAISIHDSMIRE--------KILISVGLENGEIYLYSYT-LGKFEL 745 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 54/125 (43%), Gaps = 7/125 (5%) Query: 37 VKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKE--ENGTWE 94 ++IF N +I A L H + ++ ++ G L S DRK +W+ E+ T+E Sbjct: 591 IRIFSTENWLEIKPA-LPFHSLTITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFE 647 Query: 95 -KTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE-VKKINNAHTIG 152 + H + WAP ++G + S D + + + E + V + + HT Sbjct: 648 LRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKA 707 Query: 153 CNAVS 157 A+S Sbjct: 708 VTAIS 712 >1NR0-A nrPDB Length = 611 Score = 35.0 bits (79), Expect = 0.046, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 94/239 (39%), Gaps = 33/239 (13%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H A+ G A+ +V+I+D IL + GPV ++W Sbjct: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSES 115 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +R ++ + GT +G ++NSV + P I++ GS D + Sbjct: 116 KRIAAVGEGRERFGHVFLFDTGT--SNGNLTGQARAMNSVDFKPSRPFRIIS-GSDDNTV 172 Query: 130 SLLTYTGEG-QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 ++ EG ++ K HT ++V + P GSL FAS G D Sbjct: 173 AIF----EGPPFKFKSTFGEHTKFVHSVRYNP---DGSL--------------FASTGGD 211 Query: 189 NLIKLWR---EEEDGQWKEEQ-KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 I L+ + G ++++ K AHS V + W+P + IAS S D + IW Sbjct: 212 GTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD----GTKIASASADKTIKIW 266 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/90 (23%), Positives = 42/90 (46%), Gaps = 7/90 (7%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIAD---LR--GHEGPVWQVAWA 66 H +H + + G+ A+ D ++ +++ +G + + + L+ H G V+ + W+ Sbjct: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKT 96 G +AS S D+ + IW EKT Sbjct: 249 PD--GTKIASASADKTIKIWNVATLKVEKT 276 >4U1E-I nrPDB Length = 347 Score = 34.7 bits (78), Expect = 0.062, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 8/80 (10%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHE-HSGHDSSVNSVCW 111 L GHE P+ QV + G++L SCS D +W NG T + H+G S++ C+ Sbjct: 6 LTGHERPLTQVKYNKE--GDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 112 APHDYGLILACGSSDGAISL 131 + GS+D +I L Sbjct: 64 TKY-----CVTGSADYSIKL 78 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 35/82 (42%), Gaps = 4/82 (4%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T HE + + + G L +CS D S ++ NG + + L GH G +W + Sbjct: 7 TGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER--LGTLDGHTGTIWSIDV--DC 62 Query: 70 YGNILASCSYDRKVIIWKEENG 91 + + S D + +W NG Sbjct: 63 FTKYCVTGSADYSIKLWDVSNG 84 >6J6H-n nrPDB Length = 455 Score = 34.3 bits (77), Expect = 0.077, Method: Compositional matrix adjust. Identities = 53/267 (19%), Positives = 102/267 (38%), Gaps = 35/267 (13%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G + + +D ++KI+D + + L D +GH P+ + + S S+DR V Sbjct: 175 GHLILSGGNDHTIKIWDFYHDYECL-RDFQGHNKPIKALRFTEDCQS--FLSSSFDRSVK 231 Query: 85 IWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 IW E G + + + V S PH++ + L S+ + E Q V+ Sbjct: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL---SNSKILHYDDRVSENQGLVQT 288 Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKE 204 ++ H A+ + P GS KF S D +++W + + K+ Sbjct: 289 YDH-HLSSILALKYFPD---GS--------------KFISSSEDKTVRIWENQINVPIKQ 330 Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ--DGRVFIWTCDDASGNMWSPKLLHKFN 262 HS P + + S C+Q D R++ ++ K+ + Sbjct: 331 ISDTAQHS--------MPFLNVHPSQNYFCAQSMDNRIYSFSL-KPKYKRHPKKIFKGHS 381 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLW 289 + +S + + + + GD+K L+ Sbjct: 382 SAGYGISLAFSGDGRYICSGDSKSRLF 408 >3DWL-C nrPDB Length = 377 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 52/235 (22%), Positives = 90/235 (38%), Gaps = 49/235 (20%) Query: 82 KVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 141 +V +++++ W+ S HD V V WAP I+ C S D + +G W+ Sbjct: 34 QVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKS-NRIVTC-SQDRNAYVYEKRPDGTWK 91 Query: 142 ----VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKL-WRE 196 + ++N A T V W+P KFA G +I + + E Sbjct: 92 QTLVLLRLNRAATF----VRWSPNE-----------------DKFAVGSGARVISVCYFE 130 Query: 197 EEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC------DDASG 250 +E+ W + + + W P+ L +A+ D + ++ + Sbjct: 131 QENDWWVSKHLKRPLRSTILSLDWHPNNVL----LAAGCADRKAYVLSAYVRDVDAKPEA 186 Query: 251 NMWSPKLLHKFNDV---------VWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 ++W +L FN V V V +S + N LA +G D+ VT+ S Q Sbjct: 187 SVWGSRL--PFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQ 239 Score = 32.7 bits (73), Expect = 0.19, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 7/110 (6%) Query: 27 RLATCSSDRSVKIFDVRNGG---QILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 R+ TCS DR+ +++ R G Q L+ LR + + V W+ + S + V Sbjct: 69 RIVTCSQDRNAYVYEKRPDGTWKQTLVL-LRLNRAATF-VRWSPNEDKFAVGSGARVISV 126 Query: 84 IIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 +++EN W H S++ S+ W P++ ++LA G +D +L+ Sbjct: 127 CYFEQENDWWVSKHLKRPLRSTILSLDWHPNN--VLLAAGCADRKAYVLS 174 >4V6W-Ag nrPDB Length = 318 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 59/138 (42%), Gaps = 13/138 (9%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 ++ + S D+++K+++ + I + GH V V ++ I+ SC +DR V +W Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 N + H GH+ +N+V +P G + G D L W++ Sbjct: 179 NLANCKLKNNHH--GHNGYLNTVTVSPD--GSLCTSGGKDSKALL--------WDLNDGK 226 Query: 147 NAHTIGCNAVSWAPAVVP 164 N +T+ N + A P Sbjct: 227 NLYTLEHNDIINALCFSP 244 >3JB9-g nrPDB Length = 558 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 16/74 (21%) Query: 184 SGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 SG DN IK+W D + + H+ +RD+++ SQDGR F+ Sbjct: 284 SGSMDNQIKIWEVYHDRSLL--RTFQGHARPIRDLSF--------------SQDGRSFLS 327 Query: 244 TCDDASGNMWSPKL 257 T D + +W +L Sbjct: 328 TSFDKTIKLWDTEL 341 >5I2T-A nrPDB Length = 742 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 3/41 (7%) Query: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 GQ+L A L GHEGPV ++++ ++LAS S+D+ + IW Sbjct: 488 GQLLDA-LSGHEGPVSCLSFSQE--NSVLASASWDKTIRIW 525 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G+R+ T S D +K++D+ +G +A H V V +A G ++ S S D V Sbjct: 382 GSRVVTASEDGKIKVWDITSG--FCLATFEEHTSSVTAVQFAKR--GQVMFSSSLDGTVR 437 Query: 85 IW 86 W Sbjct: 438 AW 439 >5WLC-LO nrPDB Length = 923 Score = 32.7 bits (73), Expect = 0.19, Method: Compositional matrix adjust. Identities = 18/41 (43%), Positives = 28/41 (68%), Gaps = 3/41 (7%) Query: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 GQ+L A L GHEGPV ++++ ++LAS S+D+ + IW Sbjct: 463 GQLLDA-LSGHEGPVSCLSFSQE--NSVLASASWDKTIRIW 500 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G+R+ T S D +K++D+ +G +A H V V +A G ++ S S D V Sbjct: 357 GSRVVTASEDGKIKVWDITSG--FCLATFEEHTSSVTAVQFAKR--GQVMFSSSLDGTVR 412 Query: 85 IW 86 W Sbjct: 413 AW 414 >6ID0-T nrPDB Length = 514 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 42/101 (41%), Gaps = 12/101 (11%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV--AWAHPMYGNILASCSYDRKVII 85 L TCS D + +I+DVR + L GH V V A P + + S+D + + Sbjct: 303 LVTCSRDSTARIWDVRTKAS--VHTLSGHTNAVATVRCQAAEPQ----IITGSHDTTIRL 356 Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 W G T + H SV +V P Y A GS D Sbjct: 357 WDLVAGKTRVT--LTNHKKSVRAVVLHPRHY--TFASGSPD 393 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 60/225 (26%), Positives = 84/225 (37%), Gaps = 42/225 (18%) Query: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 T S+DR++KI+D+ +G L L GH V V + L SC D++V W Sbjct: 219 FVTGSADRTIKIWDLASGK--LKLSLTGHISTVRGVIVS--TRSPYLFSCGEDKQVKCWD 274 Query: 88 EENGTWEKTHEH-SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 E + K H GH S+V + P L+ S I W+V+ Sbjct: 275 LE---YNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI----------WDVRTKA 321 Query: 147 NAHTIG--CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKE 204 + HT+ NAV+ + +P I +G D I+LW + K Sbjct: 322 SVHTLSGHTNAVATV----------RCQAAEPQII----TGSHDTTIRLW---DLVAGKT 364 Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 L H VR V P T AS S D + W D S Sbjct: 365 RVTLTNHKKSVRAVVLHPR----HYTFASGSPDN-IKQWKFPDGS 404 >4A11-B nrPDB Length = 408 Score = 32.3 bits (72), Expect = 0.25, Method: Compositional matrix adjust. Identities = 39/198 (19%), Positives = 72/198 (36%), Gaps = 44/198 (22%) Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG-----------HDSSVNSVCWAPHDY 116 P+ G + S D ++++ EN + + + H SV +V W PHD Sbjct: 53 PVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDT 112 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS----LIDQPS 172 G+ + S D + + W+ + A ++ + P S L+ + Sbjct: 113 GMFTS-SSFDKTLKV--------WDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGT 163 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 + SG C ++++ R+E + V+W+P +A Sbjct: 164 RGPKVQLCDLKSGSCSHILQGHRQE-----------------ILAVSWSPRYDY---ILA 203 Query: 233 SCSQDGRVFIWTCDDASG 250 + S D RV +W ASG Sbjct: 204 TASADSRVKLWDVRRASG 221 >6HHQ-h nrPDB Length = 319 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 63/173 (36%), Gaps = 26/173 (15%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G S S+D+ + +W G E GH S V SV +I GS D I Sbjct: 77 GAYALSASWDKTLRLWDVATG--ETYQRFVGHKSDVMSVDIDKKASMII--SGSRDKTIK 132 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + W +K A +G N VVP D S S G D + Sbjct: 133 V--------WTIKGQCLATLLGHNDWVSQVRVVPNEKADDDS-------VTIISAGNDKM 177 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 +K W Q++ E H+ + + +P L IAS +DG + +W Sbjct: 178 VKAWNLN---QFQIEADFIGHNSNINTLTASPDGTL----IASAGKDGEIMLW 223 >5YZG-W nrPDB Length = 579 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 23/44 (52%), Gaps = 1/44 (2%) Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 P+ G++L SCS D K+ +W E G GH +V +C+ Sbjct: 298 PLSGHLLLSCSMDCKIKLW-EVYGERRCLRTFIGHSKAVRDICF 340 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 3/67 (4%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G L +CS D +K+++V G + + GH V + + G S +YDR + Sbjct: 301 GHLLLSCSMDCKIKLWEVY-GERRCLRTFIGHSKAVRDICFN--TAGTQFLSAAYDRYLK 357 Query: 85 IWKEENG 91 +W E G Sbjct: 358 LWDTETG 364 >6QDV-o nrPDB Length = 513 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 23/44 (52%), Gaps = 1/44 (2%) Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 P+ G++L SCS D K+ +W E G GH +V +C+ Sbjct: 232 PLSGHLLLSCSMDCKIKLW-EVYGERRCLRTFIGHSKAVRDICF 274 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 3/67 (4%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 G L +CS D +K+++V G + + GH V + + G S +YDR + Sbjct: 235 GHLLLSCSMDCKIKLWEVY-GERRCLRTFIGHSKAVRDICFN--TAGTQFLSAAYDRYLK 291 Query: 85 IWKEENG 91 +W E G Sbjct: 292 LWDTETG 298 >5WBU-D nrPDB Length = 328 Score = 31.2 bits (69), Expect = 0.70, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 3/51 (5%) Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 ILA+ YD V W+ +G +T +H DS VN++ P D +I A G Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQH--QDSQVNALEVTP-DRSMIAAAG 63 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 40/94 (42%), Gaps = 8/94 (8%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLR----GHEGPVWQVAWAHPMYGNILASCSYDR 81 T LATCS+D++ KI+ N + ++ G W A + + S D Sbjct: 235 TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDN 294 Query: 82 KVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 +W E G E E+ GH +V VC A +D Sbjct: 295 LARLWCVETG--EIKREYGGHQKAV--VCLAFND 324 >5CXB-B nrPDB Length = 369 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 1/76 (1%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 +V T+ HE + +D G LAT D +V+++++ G Q+ L G E V Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEA-VNT 69 Query: 63 VAWAHPMYGNILASCS 78 V W ILA+ + Sbjct: 70 VRWRPTKDTFILAAAA 85 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 3/80 (3%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 RGHEG V VA G LA+ D V +W+ G + + +G D +VN+V W Sbjct: 17 FRGHEGRVRSVAID--PTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRWR 73 Query: 113 PHDYGLILACGSSDGAISLL 132 P ILA + + ++ Sbjct: 74 PTKDTFILAAAAGEDIFLMI 93 >5WLC-LW nrPDB Length = 554 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 20/28 (71%) Query: 21 MDYYGTRLATCSSDRSVKIFDVRNGGQI 48 +D G +AT +DRS+KI+D+RN Q+ Sbjct: 282 IDRSGYYMATTGADRSMKIWDIRNFKQL 309 >6HQA-B nrPDB Length = 722 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 56/238 (23%), Positives = 94/238 (39%), Gaps = 38/238 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH G V+ V ++ L SCS D+ V +W + T+ + GH SSV V ++ Sbjct: 449 LVGHSGAVYGVDFSPD--NRYLISCSEDKTVRLWSLD--TYTCLVSYKGHSSSVWDVKFS 504 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P G A S D L W C+ + + + G L D Sbjct: 505 P--MGHYFATASHDQTARL--------W-----------SCDHI-YPLRIFAGHLNDVDC 542 Query: 173 GQ-KPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 + PN F +G D ++W + + + + HS + +A +P + Sbjct: 543 VEFHPNSTYLF-TGSSDKTARMW---DIARGECVRVFMGHSGAINCLAVSPD----GRWL 594 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 AS +D V +W D ++G H ++ +++S +L +G DN V +W Sbjct: 595 ASAGEDSVVCLW--DISTGRRIKAMRGHG-RSSIYSLAFSREGTVLVSTGADNSVRVW 649 >6DKH-A nrPDB Length = 346 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 30/55 (54%), Gaps = 4/55 (7%) Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS---LLTYTGE 137 WK E G ++ + E SGH SSVN+ G+++ G GA++ ++T G+ Sbjct: 232 WKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVGMG-GAMAEFPMMTLIGK 285 >5OQL-L nrPDB Length = 557 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 60/147 (40%), Gaps = 16/147 (10%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG----NILASCSYDR 81 T L +CS D++V+++D+ + + GH V A+ M G N+L S SYD Sbjct: 158 TTLMSCSDDKTVRLWDLPSNDPTRL--FTGHTDYVRCGAF---MPGSANSNLLVSGSYDE 212 Query: 82 KVIIW-KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW 140 V +W G T +H+ + V P L+ A G+ AIS+L Sbjct: 213 TVRVWDARAPGGAVMTFKHA---DPIEDVLPLPSGTTLLAASGN---AISVLDLVAAKPL 266 Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSL 167 + + + S VV GSL Sbjct: 267 RLITNHQKTVTSLSLASQGRRVVSGSL 293 >5CXC-A nrPDB Length = 510 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 8/108 (7%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 R+ + S D ++I++ +G I + H G + A + + LAS DR V +W Sbjct: 160 RVLSASYDGLLRIWNA-SGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVW 218 Query: 87 KEE-----NGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 K G + T E GH SV+ + H ++ A S+DGAI Sbjct: 219 KYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTA--SADGAI 264 >4OWR-A nrPDB Length = 339 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 5/75 (6%) Query: 37 VKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKT 96 V+ ++V++ GQ + + H GPV V W+ ASC D+ +W + + Sbjct: 37 VRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASC--DKTAKMWDLSSN---QA 91 Query: 97 HEHSGHDSSVNSVCW 111 + + HD+ V ++ W Sbjct: 92 IQIAQHDAPVKTIHW 106 >5WYK-BB nrPDB Length = 943 Score = 28.5 bits (62), Expect = 3.6, Method: Compositional matrix adjust. Identities = 13/41 (31%), Positives = 26/41 (63%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR 43 S+++T++ +H+ I + G RL T S+D++VK +D + Sbjct: 463 SLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 Score = 27.3 bits (59), Expect = 8.4, Method: Compositional matrix adjust. Identities = 20/89 (22%), Positives = 38/89 (42%), Gaps = 8/89 (8%) Query: 206 QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVV 265 + L AH D + +V + P + SCS+D V W + + L+ V Sbjct: 609 KSLFAHQDSIMNVKFLPQ----SHNFFSCSKDAVVKYWDGE----KFECIQKLYAHQSEV 660 Query: 266 WHVSWSITANILAVSGGDNKVTLWKESVD 294 W ++ + + S D+ + +W+E+ D Sbjct: 661 WALAVATDGGFVVSSSHDHSIRIWEETED 689 >6GMH-W nrPDB Length = 305 Score = 28.5 bits (62), Expect = 4.0, Method: Compositional matrix adjust. Identities = 52/235 (22%), Positives = 86/235 (36%), Gaps = 51/235 (21%) Query: 48 ILIADLRGHEGPVWQVAWAHPMYGN--ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSS 105 IL + H+ +W VAW N + + S D V +WK + + GH Sbjct: 7 ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLG 66 Query: 106 VNSVCWAPHDYGLILACGSS-DGAISLLTYTGEGQWEVKKINNAHTIGCNAV-SWAPAVV 163 V SV + + L +A SS D I L W+++ +I V +W A Sbjct: 67 VVSVDIS---HTLPIAASSSLDAHIRL--------WDLENGKQIKSIDAGPVDAWTLAFS 115 Query: 164 PGS-------------LIDQPSGQKPNYI----------------KKFASGGCDNLIKLW 194 P S + SG+K + K ASG D +I ++ Sbjct: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 + K LE H+ +R + ++P + + + S DG + I+ A+ Sbjct: 176 ---DIATGKLLHTLEGHAMPIRSLTFSPD----SQLLVTASDDGYIKIYDVQHAN 223 >5DIZ-A nrPDB Length = 531 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 51/129 (39%), Gaps = 11/129 (8%) Query: 137 EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWRE 196 EG+W VKK N + T C + S A V D + ++ + D K+ Sbjct: 268 EGKWTVKKGNVSSTGRCLSCSEQLACV-----DTNEVETQKFVDSLVALAMDRKTKMNSC 322 Query: 197 EEDGQWKEEQK-LEAHSDWVRDVAWAPSIGLPTSTIA----SCSQDGRVFIWTCDDASGN 251 E + + E Q LE H D+ V A +IGL S SQ V ++ N Sbjct: 323 ETNVVFSEFQDWLEKHGDYEAIVDGA-NIGLYQQNFVDGSFSLSQLESVMKELYRESGNN 381 Query: 252 MWSPKLLHK 260 W LLHK Sbjct: 382 KWPLILLHK 390 >5K0Y-T nrPDB Length = 329 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 30/131 (22%), Positives = 46/131 (35%), Gaps = 17/131 (12%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H I+D Q+ T T S D + K+FD L P ++A P Y Sbjct: 187 HSRQINDIQLSREMTMFVTASKDNTAKLFD----STTLEHQKTFRTEPPRELAALSPNYE 242 Query: 72 NILASCSYD-RKVIIWKEENGTWEKTHEH----------SGHDSSVNSVCWAPHDYGLIL 120 +++ + V G +E H GH +NSV + P G Sbjct: 243 HVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPD--GKSY 300 Query: 121 ACGSSDGAISL 131 + G DG + + Sbjct: 301 SSGGEDGYVRI 311 >6DAM-A nrPDB Length = 617 Score = 28.1 bits (61), Expect = 5.6, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 64/161 (39%), Gaps = 20/161 (12%) Query: 22 DYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP---VWQVAWAHPMYGNILASCS 78 +Y+GTR + + + +++ LRGHEG V V + H + N + + Sbjct: 46 NYHGTRYSELKQINTSNVKNLQPAWTFSTGVLRGHEGGPLVVNDVMYIHTPFPNTVYAID 105 Query: 79 YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS-----SDGAISLL- 132 + +I WE T + D ++ +C + GL G SD ++ L Sbjct: 106 QKTQAVI-------WEYTPQQDA-DVTIPVMCCDTVNRGLAYGDGKIFLQQSDTVLTALD 157 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 TG+ W V+ N +G AP VV +I SG Sbjct: 158 AKTGKRVWSVQ--NGDPKLGMTNTQ-APLVVKDKVITGISG 195 >4X8N-A nrPDB Length = 181 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 4/45 (8%) Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG-HDSS 105 ++ W+ P+ GN+ A YD+ W+ + GT K H+ G H SS Sbjct: 58 RLGWSQPL-GNLQAPLGYDKFSYSWRSKKGT--KFHQSIGKHYSS 99 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3BG0-A nrPDB 394 e-110 4YCZ-A nrPDB 336 8e-93 3JRO-A nrPDB 307 4e-84 4L9O-A nrPDB 300 5e-82 3JRP-A nrPDB 289 2e-78 4BZK-B nrPDB 281 2e-76 5A9Q-7 nrPDB 236 8e-63 1VYH-C nrPDB 215 2e-56 5OQL-J nrPDB 211 3e-55 3F3P-A nrPDB 210 8e-55 6QX9-5O nrPDB 204 5e-53 3FM0-A nrPDB 194 5e-50 5FL8-q nrPDB 171 3e-43 6EMK-B nrPDB 170 6e-43 6F3T-A nrPDB 168 2e-42 6MZM-G nrPDB 168 3e-42 5NNZ-B nrPDB 163 8e-41 5M25-A nrPDB 162 2e-40 2H9P-A nrPDB 156 2e-38 5WYJ-BC nrPDB 155 3e-38 5Z56-q nrPDB 153 7e-38 4LG8-A nrPDB 147 6e-36 4BTS-AR nrPDB 147 8e-36 6G51-g nrPDB 146 2e-35 6BX3-A nrPDB 140 9e-34 2HES-X nrPDB 139 1e-33 3JAP-g nrPDB 137 5e-33 5WJC-A nrPDB 134 3e-32 5FA5-B nrPDB 134 6e-32 6EOJ-D nrPDB 130 7e-31 4G56-B nrPDB 129 1e-30 6N9G-C nrPDB 129 2e-30 3JB9-L nrPDB 128 5e-30 5K1B-B nrPDB 121 5e-28 4XYI-A nrPDB 120 6e-28 4V8M-A7 nrPDB 120 6e-28 5OQL-d nrPDB 116 1e-26 6CHG-A nrPDB 116 1e-26 5Y1U-A nrPDB 112 2e-25 2AQ5-A nrPDB 111 5e-25 5Y88-O nrPDB 110 6e-25 5L9T-R nrPDB 110 8e-25 2P9P-C nrPDB 106 2e-23 4PSX-B nrPDB 103 1e-22 Sequences not found previously or not previously below threshold: 5MZH-A nrPDB 169 1e-42 5FVM-C nrPDB 159 2e-39 6HQA-B nrPDB 154 4e-38 3DM0-A nrPDB 152 2e-37 4V6W-Ag nrPDB 139 1e-33 6QX9-4B nrPDB 131 5e-31 5GAN-H nrPDB 131 5e-31 5NZU-C nrPDB 129 2e-30 6QDV-o nrPDB 124 4e-29 5YZG-W nrPDB 124 4e-29 6ID0-T nrPDB 124 4e-29 6HHQ-h nrPDB 121 3e-28 3MKQ-A nrPDB 118 3e-27 5OPT-p nrPDB 118 4e-27 2YNP-A nrPDB 115 3e-26 3C9C-A nrPDB 115 3e-26 3CFV-B nrPDB 114 6e-26 5G04-R nrPDB 109 1e-24 4V7E-Bg nrPDB 108 4e-24 5WBU-D nrPDB 107 7e-24 4GGA-A nrPDB 107 7e-24 6Q8F-A nrPDB 107 8e-24 5LCW-Q nrPDB 106 1e-23 5WYK-BB nrPDB 105 2e-23 5XYI-g nrPDB 104 4e-23 4XFV-A nrPDB 104 6e-23 6J6H-n nrPDB 102 1e-22 4N14-A nrPDB 102 2e-22 5UZ7-B nrPDB 102 3e-22 5WLC-LO nrPDB 101 3e-22 3JB9-g nrPDB 101 4e-22 5I2T-A nrPDB 100 1e-21 6GMH-W nrPDB 99 1e-21 4J0W-A nrPDB 94 7e-20 3ODT-A nrPDB 93 2e-19 4A11-B nrPDB 91 6e-19 4AEZ-A nrPDB 91 6e-19 5A31-R nrPDB 90 9e-19 3DWL-C nrPDB 90 2e-18 3W15-A nrPDB 89 2e-18 5OQL-L nrPDB 88 4e-18 4BH6-A nrPDB 88 4e-18 4OWR-A nrPDB 88 7e-18 5WLC-LU nrPDB 87 1e-17 5N4A-A nrPDB 86 2e-17 3JZG-A nrPDB 85 3e-17 5WLC-LJ nrPDB 85 4e-17 5OQL-X nrPDB 85 5e-17 4U1E-I nrPDB 84 7e-17 6ELZ-p nrPDB 83 2e-16 6E29-D nrPDB 82 4e-16 1NR0-A nrPDB 81 9e-16 2PM9-A nrPDB 80 1e-15 5CXC-A nrPDB 80 1e-15 5CXB-B nrPDB 79 2e-15 6CB1-s nrPDB 77 8e-15 6EM1-m nrPDB 77 9e-15 6F1U-h nrPDB 77 1e-14 6C0F-s nrPDB 77 1e-14 5K0Y-T nrPDB 77 1e-14 3ACP-A nrPDB 76 3e-14 5BJS-A nrPDB 74 1e-13 5MWJ-A nrPDB 73 2e-13 6BX3-B nrPDB 73 2e-13 5OV3-A nrPDB 69 3e-12 4J0X-A nrPDB 69 3e-12 4E5Z-B nrPDB 68 4e-12 5WLC-LN nrPDB 68 5e-12 5WLC-SG nrPDB 68 5e-12 5YZG-2 nrPDB 68 5e-12 5K19-A nrPDB 65 3e-11 6CHG-D nrPDB 65 4e-11 5WYJ-BE nrPDB 64 1e-10 5AMS-A nrPDB 63 1e-10 1PI6-A nrPDB 63 2e-10 5A9Q-0 nrPDB 62 4e-10 5A9Q-2 nrPDB 59 2e-09 5WLC-LS nrPDB 59 3e-09 5M89-A nrPDB 56 2e-08 5TF2-A nrPDB 53 2e-07 3I2N-A nrPDB 51 1e-06 5WLC-LH nrPDB 49 2e-06 6IYY-A nrPDB 49 3e-06 3EI3-B nrPDB 49 4e-06 3DW8-B nrPDB 48 5e-06 5MC6-j nrPDB 48 6e-06 2I3T-A nrPDB 45 5e-05 6CVZ-A nrPDB 44 9e-05 5WLC-LW nrPDB 44 9e-05 3JB9-S nrPDB 42 4e-04 2VDU-B nrPDB 41 5e-04 4FHN-A nrPDB 41 7e-04 4AV8-A nrPDB 38 0.005 5LTD-A nrPDB 38 0.009 4YHC-A nrPDB 38 0.009 5GRS-A nrPDB 37 0.013 6N8P-A nrPDB 34 0.060 5CWW-B nrPDB 33 0.21 4MHC-A nrPDB 32 0.33 1NDS-A nrPDB 31 1.1 1OI2-A nrPDB 30 1.7 3O9P-A nrPDB 29 2.1 5BPT-A nrPDB 29 2.5 5TXC-A nrPDB 29 2.6 6DKH-A nrPDB 29 3.3 1RI6-A nrPDB 27 7.7 4XXF-A nrPDB 27 8.6 >3BG0-A nrPDB Length = 316 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 307/316 (97%), Positives = 313/316 (99%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV Sbjct: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 WQVAWAHPMYGNILASCSYDRKVIIW+EENGTWEK+HEH+GHDSSVNSVCWAPHDYGLIL Sbjct: 61 WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL 120 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID PSGQKPNYIK Sbjct: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 180 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 +FASGGCDNLIKLW+EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV Sbjct: 181 RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 Query: 241 FIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 FIWTCDDAS N WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI Sbjct: 241 FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 Query: 301 SDVNKGQGSVSASITE 316 SDVNKGQGSVSAS+TE Sbjct: 301 SDVNKGQGSVSASVTE 316 >4YCZ-A nrPDB Length = 876 Score = 336 bits (861), Expect = 8e-93, Method: Composition-based stats. Identities = 149/300 (49%), Positives = 205/300 (68%), Gaps = 6/300 (2%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 ++ H+DMIHDA +DYYG RLATCSSDR++KIF++ Q L L+GH+G VW V+WAH Sbjct: 13 ANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAH 72 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P YGNILAS YD KV+IW+E NG W++ + + H +SVN V W+PH+ G +LAC SSDG Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 +S+L + + WE I +AH +G N+VSWAPA PGS++ G K ++F +GG Sbjct: 133 NVSVLEFR-DNSWE-HSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGS 190 Query: 188 DNLIKLWREE--EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 DN +K+W + + E + L H+DWVRDVAW+P++ L S IAS S+D V IWT Sbjct: 191 DNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTV-LQKSYIASASEDRTVRIWTS 249 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 D A+ W+ K+L F+ VW VSWS++ N+LA SGGDNKVTLWKE++ G+W C+ + + Sbjct: 250 DPANPLQWNCKVL-NFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIEE 308 >3JRO-A nrPDB Length = 753 Score = 307 bits (786), Expect = 4e-84, Method: Composition-based stats. Identities = 153/307 (49%), Positives = 200/307 (65%), Gaps = 12/307 (3%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 MV + N +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPV Sbjct: 1 MVVIAN----AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPV 56 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 W+V WAHP +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L Sbjct: 57 WRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLL 116 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 SSDG +S++ + G I+ AH IG N+ SWAPA + + Sbjct: 117 LVASSDGKVSVVEFKENGTTSPIIID-AHAIGVNSASWAPATIEED----GEHNGTKESR 171 Query: 181 KFASGGCDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 KF +GG DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD Sbjct: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRT 230 Query: 240 VFIWTCDDASGNMWSPKLL-HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 IWT D+ G L KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 Query: 299 CISDVNK 305 +V++ Sbjct: 291 PAGEVHQ 297 >4L9O-A nrPDB Length = 349 Score = 300 bits (768), Expect = 5e-82, Method: Composition-based stats. Identities = 159/301 (52%), Positives = 203/301 (67%), Gaps = 16/301 (5%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 T+ +H+D+IHDA +DYYG RLATCSSD+++KIF++ Q L+ L GHEGPVWQVAWA Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA 122 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 HP +G ILASCSYD KV+IWKE+NG W K EHS H +SVNSV WAPH+YG +L C SSD Sbjct: 123 HPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 182 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 G IS++ + G E I H IG NA SWAP +P + ++F SGG Sbjct: 183 GKISIVEFKDGGALEPIVI-QGHAIGVNAASWAPISLPDNT------------RRFVSGG 229 Query: 187 CDNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 CDNL+K+WR ++ + + EE+ + HSDWVRDVAW+PS L S IA+ SQD V IWT Sbjct: 230 CDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPS-RLSKSYIATASQDRTVLIWTK 288 Query: 246 DDASGNM-WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVN 304 D S P KF DV W SWS++ N+LA+SGGDNKVTLWKE++ G+W +V+ Sbjct: 289 DGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVD 348 Query: 305 K 305 + Sbjct: 349 Q 349 >3JRP-A nrPDB Length = 379 Score = 289 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 150/300 (50%), Positives = 197/300 (65%), Gaps = 8/300 (2%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPVW+V WAH Sbjct: 6 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 65 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L SSDG Sbjct: 66 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 125 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 +S++ + G I+ AH IG N+ SWAPA + +KF +GG Sbjct: 126 KVSVVEFKENGTTSPIIID-AHAIGVNSASWAPATIEED----GEHNGTKESRKFVTGGA 180 Query: 188 DNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD IWT D Sbjct: 181 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRTCIIWTQD 239 Query: 247 DASGNMWSPKLL-HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 + G L KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W +V++ Sbjct: 240 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 9/99 (9%) Query: 4 VINTVDTSHEDMIHDAQMDYY---GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP- 59 V+ + H D + D + LA+ S DR+ I+ N L E Sbjct: 197 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 256 Query: 60 --VWQVAWAHPMYGNILASCSYDRKVIIWKEE-NGTWEK 95 +W+ +W+ + GN+LA D KV +WKE G WE Sbjct: 257 DVLWRASWS--LSGNVLALSGGDNKVTLWKENLEGKWEP 293 >4BZK-B nrPDB Length = 297 Score = 281 bits (719), Expect = 2e-76, Method: Composition-based stats. Identities = 150/300 (50%), Positives = 197/300 (65%), Gaps = 8/300 (2%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + +H ++IHDA +DYYG RLATCSSD+++KIF+V LI L GHEGPVW+V WAH Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P +G ILASCSYD KV+IWKEENG W + H+ H +SVNSV WAPH+YG +L SSDG Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 +S++ + G I+ AH IG N+ SWAPA + +KF +GG Sbjct: 124 KVSVVEFKENGTTSPIIID-AHAIGVNSASWAPATIEED----GEHNGTKESRKFVTGGA 178 Query: 188 DNLIKLWREEEDGQ-WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 DNL+K+W+ D Q + E LE HSDWVRDVAW+P++ L S +AS SQD IWT D Sbjct: 179 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRTCIIWTQD 237 Query: 247 DASGNMWSPKLL-HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 + G L KF DV+W SWS++ N+LA+SGGDNKVTLWKE+++G+W +V++ Sbjct: 238 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 28/99 (28%), Positives = 42/99 (42%), Gaps = 9/99 (9%) Query: 4 VINTVDTSHEDMIHDAQMDYY---GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP- 59 V+ + H D + D + LA+ S DR+ I+ N L E Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP 254 Query: 60 --VWQVAWAHPMYGNILASCSYDRKVIIWKEE-NGTWEK 95 +W+ +W+ + GN+LA D KV +WKE G WE Sbjct: 255 DVLWRASWS--LSGNVLALSGGDNKVTLWKENLEGKWEP 291 >5A9Q-7 nrPDB Length = 360 Score = 236 bits (602), Expect = 8e-63, Method: Composition-based stats. Identities = 101/343 (29%), Positives = 158/343 (46%), Gaps = 35/343 (10%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGPVWQ 62 V ++ H+D+IHD D++G R+ATCSSD+SVK++D +G A + H G VW+ Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENG----------TWEKTHEHSGHDSSVNSVCWA 112 V WAHP +G +LASCS+DR +W+E G W K +SV V +A Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 113 PHDYGLILACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169 P GL+LA S+DG + + QW ++ + + C+ +SW P+ Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEIS-CKLSCSCISWNPSSSRAHSPM 181 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEED-GQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 G + A ++++ E+ ++ + + L +D V D+A+AP++G Sbjct: 182 IAVGSDDSSPNAMA------KVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSF 235 Query: 229 STIASCSQDGRVFIWTCDDASGNMWSPKL-----------LHKFNDVVWHVSWSITANIL 277 +A ++D V I+T + S N VW VSW+IT +L Sbjct: 236 HILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVL 293 Query: 278 AVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQN 320 A SG D V LWK + W C + V+ S +G N Sbjct: 294 ASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSN 336 >1VYH-C nrPDB Length = 410 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 111/283 (39%), Gaps = 25/283 (8%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D + D D+ G LA+CS+D ++K++D + I + GH+ V V+ Sbjct: 148 GHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF--ECIRTMHGHDHNVSSVSIMP--N 203 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ + S S D+ + +W+ + G KT +GH V V P+ G ++A S+D + Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKT--FTGHREWVRMVR--PNQDGTLIASCSNDQTVR 259 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK---FASGGC 187 + E K H +SWAP S+ + + K SG Sbjct: 260 VWVV---ATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSR 316 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D IK+W L H +WVR V + I SC+ D + +W Sbjct: 317 DKTIKMWDV---STGMCLMTLVGHDNWVRGVLFHSG----GKFILSCADDKTLRVWD--- 366 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 N K L+ V + + TA + D V +W+ Sbjct: 367 -YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 53/298 (17%), Positives = 97/298 (32%), Gaps = 54/298 (18%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH PV +V + HP++ ++ S S D + +W E G +E+T GH SV + + Sbjct: 104 LSGHRSPVTRVIF-HPVFS-VMVSASEDATIKVWDYETGDFERT--LKGHTDSVQDISF- 158 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCN------------------ 154 G +LA S+D I L + G ++ + + Sbjct: 159 -DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 155 ----AVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEA 210 + G + AS D +++W + + +L Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV---ATKECKAELRE 274 Query: 211 HSDWVRDVAWAPS----------------IGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 H V ++WAP G P + S S+D + +W Sbjct: 275 HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG----MC 330 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSA 312 L ++ V V + + D + +W C+ +N + V++ Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY---KNKRCMKTLNAHEHFVTS 385 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 73/203 (35%), Gaps = 44/203 (21%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H + + + + GT +A+CS+D++V+++ V + A+LR H V ++WA Sbjct: 231 TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT--KECKAELREHRHVVECISWAPES 288 Query: 70 Y------------------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 G L S S D+ + +W G GHD+ V V + Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC--LMTLVGHDNWVRGVLF 346 Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 H G + + D + + Y + + NAH ++ + Sbjct: 347 --HSGGKFILSCADDKTLRVWDYKNKRCMKTL---NAHEHFVTSLDFH------------ 389 Query: 172 SGQKPNYIKKFASGGCDNLIKLW 194 +G D +K+W Sbjct: 390 -----KTAPYVVTGSVDQTVKVW 407 Score = 94.9 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 71/220 (32%), Gaps = 36/220 (16%) Query: 91 GTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHT 150 + + SGH S V V + P ++ S D I + Y K HT Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFS--VMVSASEDATIKVWDYETGDFERTLK---GHT 150 Query: 151 IGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEA 210 +S+ + K AS D IKLW + ++ + + Sbjct: 151 DSVQDISF-----------------DHSGKLLASCSADMTIKLWDFQG---FECIRTMHG 190 Query: 211 HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSW 270 H V V+ P+ I S S+D + +W K + V V Sbjct: 191 HDHNVSSVSIMPN----GDHIVSASRDKTIKMWEVQTGY----CVKTFTGHREWVRMVRP 242 Query: 271 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 + ++A D V +W + C +++ + + V Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATK---ECKAELREHRHVV 279 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 42/111 (37%), Gaps = 11/111 (9%) Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFND 263 E+ L H V V + P S + S S+D + +W + + L D Sbjct: 100 EKYALSGHRSPVTRVIFHP----VFSVMVSASEDATIKVWDYETGDFE----RTLKGHTD 151 Query: 264 VVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASI 314 V +S+ + +LA D + LW + CI ++ +VS+ Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWDFQ---GFECIRTMHGHDHNVSSVS 199 Score = 63.7 bits (153), Expect = 9e-11, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H++ + G + +C+ D++++++D +N + + L HE V + + H Sbjct: 336 GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN--KRCMKTLNAHEHFVTSLDF-HKTA 392 Query: 71 GNILASCSYDRKVIIWKEE 89 + + S D+ V +W+ Sbjct: 393 P-YVVTGSVDQTVKVWECR 410 Score = 34.4 bits (77), Expect = 0.068, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 16/34 (47%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR 43 +HE + + T S D++VK+++ R Sbjct: 377 NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >5OQL-J nrPDB Length = 912 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 114/307 (37%), Gaps = 41/307 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIF--DVRNGGQILIADLRGHEGPVWQVA---- 64 HED++ +D+ G +A+ S D + +++ D N A GH V VA Sbjct: 431 GHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKV 490 Query: 65 --------WAHP--MYGNILASCSYDRKVIIWKE-----ENGTWEKTHEHSGHDSSVNSV 109 + +P L S S DR V + G + HD +N++ Sbjct: 491 VPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINAL 550 Query: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169 +P+ G + A S D + + + EV+ I H G V +AP P + Sbjct: 551 DISPN--GKLFASASQDKTVKIWDVE---KLEVQGILRGHKRGVWTVRFAPLNTPVIQGE 605 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAW-----APSI 224 Q S + +G D IKLW + + E HS V V W SI Sbjct: 606 QGSVSGRGVV---LTGSGDKTIKLWNL---SDYTCIRTFEGHSHNVLKVVWLHISRDDSI 659 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 AS D V +W + L D +W ++ NILA +G D+ Sbjct: 660 TKTKVQFASAGADTLVKVWDANTGETEC----TLDNHEDRLWTLAVHSKTNILASAGSDS 715 Query: 285 KVTLWKE 291 KVT W++ Sbjct: 716 KVTFWRD 722 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 60/391 (15%), Positives = 122/391 (31%), Gaps = 89/391 (22%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNG--------GQILIADLR 54 +++ T H + +D T LAT ++D ++KI+D+ G +L++ L Sbjct: 102 TLVRTTKP-HATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALH 160 Query: 55 GHEGPVWQVAWAHPMYGN------------------ILASCSYDRKVIIWKEENGTWEKT 96 E V + + LA + D ++ I+ T Sbjct: 161 FFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPV 220 Query: 97 H-----EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT---------------- 135 + + H+S+V + ++P + L GS D ++L + Sbjct: 221 YADPKRKKEAHESNVQCIAYSPEQH--ALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLE 278 Query: 136 -----GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK-----FASG 185 EG+W + + + + + + Sbjct: 279 SVGFLNEGKWMYSAGTSG-VLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCA 337 Query: 186 GCDNLIKLWREEEDGQWKEE---------QKLEAHSDWVRDVAW-APSIGLPTSTIASCS 235 D + L+R +++ D + D+ + P + IA+ S Sbjct: 338 QADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMA--IATNS 395 Query: 236 QDGRVFIWTCDDA------SGNMWS-------PKLLHKFNDVVWHVSWSITANILAVSGG 282 +D + I + DA + S LL D+V + + + +A Sbjct: 396 ED--IRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSK 453 Query: 283 DNKVTLWK-ESVDGQWVCISDVNKGQGSVSA 312 DN LW+ + + + C + SV A Sbjct: 454 DNTARLWRVDPANNSYTCYAVFTGHLESVGA 484 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 45/275 (16%), Positives = 86/275 (31%), Gaps = 30/275 (10%) Query: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 +HE + L + S D+++ ++ R+G LR + V + + Sbjct: 228 KEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLR--HELLESVGFLN- 284 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 G + S + IW + + + + + LIL C +D Sbjct: 285 -EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLIL-CAQADFT 342 Query: 129 ISLLTYTGEGQWEV----------KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 + L ++I+ H + P ++ + Sbjct: 343 LVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVS 402 Query: 179 IKKFASGGCDNLIKLWREEEDGQW--KEEQKLEAHSDWV--RDVAWAPSIGLPTSTIASC 234 +K + DN E G + + L+ H D V DV W+ IAS Sbjct: 403 VKDAQAYSEDNA-----ECRSGSYFGHDVALLKGHEDIVMSLDVDWS------GHWIASG 451 Query: 235 SQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVS 269 S+D +W D A+ + + + V V+ Sbjct: 452 SKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVA 486 Score = 68.3 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 48/305 (15%), Positives = 104/305 (34%), Gaps = 36/305 (11%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 VI + T ++ LA+ + ++ +A+++G P+ + Sbjct: 16 VIQPIYTG-----GSVALENGARILASTLGENAIL---TELNTGKRLAEIQGDGEPISTL 67 Query: 64 AWAHPMYGNILASCSYDRKVIIWKE----ENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 G+ L CS + I+ + + E T + + V A + Sbjct: 68 TITP--SGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTL 125 Query: 120 LACGSSDGAISLLTYTGEGQWEVKK-----INNAHTIGCNAVSWAPAVVPGSLIDQPSGQ 174 LA G++DGAI + G ++ H + + + GQ Sbjct: 126 LATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQ 185 Query: 175 KPNYIK-----KFASGGCDNLIKLWREEEDGQWK----EEQKLEAHSDWVRDVAWAPSIG 225 + + + A G D I+++ + ++K EAH V+ +A++P Sbjct: 186 NDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP--- 242 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNK 285 + S S+D + +W D +W + + ++ V + + +G Sbjct: 243 -EQHALLSGSRDKTMTLWLWRDG---IWQGTPMLRHE-LLESVGFLNEGKWMYSAGTSGV 297 Query: 286 VTLWK 290 + +W Sbjct: 298 LRIWD 302 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 47/139 (33%), Gaps = 12/139 (8%) Query: 156 VSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWV 215 ++ A V + S N + AS +N I E K +++ + + Sbjct: 9 TTFEVANVIQPIYTGGSVALENGARILASTLGENAI----LTELNTGKRLAEIQGDGEPI 64 Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTC----DDASGNMWSPKLLHKFNDVVWHVSWS 271 + PS S + CS+ + I++ D S + V ++ Sbjct: 65 STLTITPS----GSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVD 120 Query: 272 ITANILAVSGGDNKVTLWK 290 T+ +LA D + +W Sbjct: 121 RTSTLLATGAADGAIKIWD 139 >3F3P-A nrPDB Length = 351 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 99/364 (27%), Positives = 153/364 (42%), Gaps = 76/364 (20%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIF--DVRNGGQILIADLRGHEGPVWQ 62 + D+ H+D++HD D+YG +ATCSSD+ +K+F D L R H+ + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEE-------NGTWEKTHEHSGHDSSVNSVCWAPHD 115 + WA P YG I+AS SYD+ V +W+E+ W K + S+ SV +AP Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 116 YGLILACGSSDGAISLLT---------YTGEGQWEVKKINNA-HTIGCNAVSWAPAVVPG 165 GL LAC +DG + L +T + +V I A H +SW P+ Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 166 SLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 +K A + I +++ +DG+ KL H +R ++WAPSIG Sbjct: 183 --------------EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 227 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK------------------------- 260 IA+ +DGR+ I+ + + S + L Sbjct: 228 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 287 Query: 261 -----------------FNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 N VW VSW++T IL+ +G D KV LWK + ++ C+S + Sbjct: 288 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 347 Query: 304 NKGQ 307 Q Sbjct: 348 TAQQ 351 >6QX9-5O nrPDB Length = 357 Score = 204 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 117/307 (38%), Gaps = 43/307 (14%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 + HE ++ + G+ LA+ DR + +++V G A L+GH G V ++ + Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTD- 120 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC-GSSDGA 128 G++L S S D+ V +W E G E+ GH S VNS P G L C GS DG Sbjct: 121 -GSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDDGT 175 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 + L + + AV D + SGG D Sbjct: 176 VKLWDIRKKAAIQT----------FQNTYQVLAVTFNDTSD-----------QIISGGID 214 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 N IK+W ++ K + H+D V ++ + S + S + D V +W Sbjct: 215 NDIKVWDLRQN---KLTYTMRGHADSVTGLSLSS----EGSYLLSNAMDNTVRVWDVRPF 267 Query: 249 SGNMWSPKLL----HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVN 304 + K+ H F + SWS + +A D V +W + + + Sbjct: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR---RILYKLP 324 Query: 305 KGQGSVS 311 GS++ Sbjct: 325 GHAGSIN 331 Score = 88.4 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 30/125 (24%), Positives = 58/125 (46%), Gaps = 12/125 (9%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRN--GGQILIADLRG--H--EGPVWQVA 64 H D + + G+ L + + D +V+++DVR + + +G H E + + + Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 W+ G+ +A+ S DR V +W + ++ GH S+N V + P + I+ S Sbjct: 293 WSPD--GSKIAAGSADRFVYVWDTTSRRI--LYKLPGHAGSINEVAFHPDE--PIIISAS 346 Query: 125 SDGAI 129 SD + Sbjct: 347 SDKRL 351 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 22/54 (40%), Gaps = 2/54 (3%) Query: 257 LLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 LL V+ + + LA +G D + LW +V G + + G+V Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAV 112 Score = 32.1 bits (71), Expect = 0.31, Method: Composition-based stats. Identities = 5/34 (14%), Positives = 15/34 (44%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR 43 H I++ + + SSD+ + + +++ Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 >3FM0-A nrPDB Length = 345 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 83/286 (29%), Positives = 126/286 (44%), Gaps = 39/286 (13%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASC 77 + GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASA 79 Query: 78 SYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGE 137 S+D IWK+ +E GH++ V SV WAP G +LA S D ++ + E Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP--SGNLLATCSRDKSVWVWEVDEE 137 Query: 138 GQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREE 197 ++E + N+HT V W P+ + AS D+ +KL+REE Sbjct: 138 DEYECVSVLNSHTQDVKHVVWHPSQ-----------------ELLASASYDDTVKLYREE 180 Query: 198 EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCD 246 ED W LE H V +A+ PS +ASCS D V IW C Sbjct: 181 ED-DWVCCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACS 235 Query: 247 DASGNMWSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 291 + + L F+ ++ ++W LA + GD+ + +++E Sbjct: 236 GSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281 Score = 150 bits (378), Expect = 7e-37, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 109/307 (35%), Gaps = 46/307 (14%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + H+ + G LA+ S D + I+ + L GHE V VAWA Sbjct: 56 LSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP 115 Query: 68 PMYGNILASCSYDRKVIIWKE-ENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 GN+LA+CS D+ V +W+ E +E + H V V W P +LA S D Sbjct: 116 --SGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQ--ELLASASYD 171 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 + L E W H ++++ P+ ++ AS Sbjct: 172 DTVKLYR-EEEDDWVCCATLEGHESTVWSLAFDPS-----------------GQRLASCS 213 Query: 187 CDNLIKLWRE------------EEDGQWKEEQKLEA-HSDWVRDVAWAPSIGLPTSTIAS 233 D +++WR+ D WK L HS + D+AW T +A+ Sbjct: 214 DDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC----QLTGALAT 269 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLL-----HKFNDVVWHVSWSITAN-ILAVSGGDNKVT 287 D + ++ D S L + V V+W+ +LA D +V Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVA 329 Query: 288 LWKESVD 294 WK Sbjct: 330 FWKYQRP 336 Score = 136 bits (341), Expect = 1e-32, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 99/258 (38%), Gaps = 41/258 (15%) Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHS-GHDSSVNSVCWAPHDYGLI 119 W +AW G +LASC DR++ IW E +W S GH +V V W+P G Sbjct: 20 WFLAWNP--AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNY 75 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 LA S D + + E H +V+WAP+ Sbjct: 76 LASASFDATTCIWKKNQDDF-ECVTTLEGHENEVKSVAWAPS-----------------G 117 Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 A+ D + +W +E+ +++ L +H+ V+ V W PS L +AS S D Sbjct: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQEL----LASASYDDT 173 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ--- 296 V ++ + + L VW +++ + LA D V +W++ + G Sbjct: 174 VKLY--REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQG 231 Query: 297 ---------WVCISDVNK 305 W CI ++ Sbjct: 232 VACSGSDPSWKCICTLSG 249 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 99/248 (39%), Gaps = 24/248 (9%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV-RNGGQILIADLRGHEGPVWQVAW 65 T HE+ + G LATCS D+SV +++V ++ L H V V W Sbjct: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW 158 Query: 66 AHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 +LAS SYD V +++EE W GH+S+V S+ + P G LA S Sbjct: 159 HPSQ--ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDP--SGQRLASCSD 214 Query: 126 DGAISLLTYTGEGQWEVKKINNAHTIG---CNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 D + + G + + + C + + Q +G Sbjct: 215 DRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA-------L 267 Query: 183 ASGGCDNLIKLWREEEDGQ-----WKEEQKL-EAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 A+ D+ I++++E+ + + L +AHS V VAW P +ASCS Sbjct: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP---KEPGLLASCSD 324 Query: 237 DGRVFIWT 244 DG V W Sbjct: 325 DGEVAFWK 332 Score = 97.2 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 50/212 (23%), Positives = 76/212 (35%), Gaps = 40/212 (18%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 +V SH + LA+ S D +VK++ + A L GHE VW +A+ Sbjct: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF- 202 Query: 67 HPMYGNILASCSYDRKVIIWKEE-------------NGTWEKTHEHSG-HDSSVNSVCWA 112 G LASCS DR V IW++ + +W+ SG H ++ + W Sbjct: 203 -DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC 261 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWE------VKKINNAHTIGCNAVSWAPAVVPGS 166 L ACG D AI + + ++ AH+ N V+W P Sbjct: 262 QLTGALATACG--DDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP------ 313 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEE 198 AS D + W+ + Sbjct: 314 ----------KEPGLLASCSDDGEVAFWKYQR 335 Score = 94.5 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 6/129 (4%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 AS G D I++W E D + E H VR VAW+P + +AS S D Sbjct: 31 LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP----CGNYLASASFDATTC 86 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCIS 301 IW + + L + V V+W+ + N+LA D V +W+ + ++ C+S Sbjct: 87 IWKKN--QDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVS 144 Query: 302 DVNKGQGSV 310 +N V Sbjct: 145 VLNSHTQDV 153 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 12/46 (26%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 262 NDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 + W ++W+ +LA GGD ++ +W + W+C S +++G Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWG-TEGDSWICKSVLSEGH 60 Score = 31.3 bits (69), Expect = 0.49, Method: Composition-based stats. Identities = 8/40 (20%), Positives = 16/40 (40%), Gaps = 1/40 (2%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIF 40 S+ + +H ++ + LA+CS D V + Sbjct: 292 FSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331 >5FL8-q nrPDB Length = 515 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 72/347 (20%), Positives = 111/347 (31%), Gaps = 85/347 (24%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH--- 67 H + + G +AT S D +++++D ++G L LRGH + ++W Sbjct: 184 GHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQC-LGDALRGHSKWITSLSWEPIHL 242 Query: 68 --PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 P LAS S D + IW + + + SGH +SV+ V W +L GS Sbjct: 243 VKPGSKPRLASSSKDGTIKIWDTVSRVCQ--YTMSGHTNSVSCVKW---GGQGLLYSGSH 297 Query: 126 DGAISLLTYTGEGQWE-------------------------------------------- 141 D + + +G+ Sbjct: 298 DRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKAL 357 Query: 142 ------VKKINNAHTIGCNA------VSWAPAVVPGSLIDQPSGQK-------PNYIKKF 182 KK N+ + A W P + QK + Sbjct: 358 ENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYI 417 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 S DN IKLW + K H V VAW+ L + SCS+D + + Sbjct: 418 VSASFDNSIKLW---DGRDGKFISTFRGHVASVYQVAWSSDCRL----LVSCSKDTTLKV 470 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 W ++ P D V+ V WS+ + G D V LW Sbjct: 471 WDVRTRKLSVDLP----GHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 146 bits (367), Expect = 1e-35, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 118/350 (33%), Gaps = 75/350 (21%) Query: 2 VSVINTVDTSHEDMIHDAQMDYY-GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 V+ ++ H I + + +R+ T + D + +I+D Q + L+GH V Sbjct: 132 VTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDT--QTPMHTLKGHYNWV 189 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD----- 115 V+W+ G ++A+ S D + +W ++G GH + S+ W P Sbjct: 190 LCVSWSPD--GEVIATGSMDNTIRLWDPKSGQC-LGDALRGHSKWITSLSWEPIHLVKPG 246 Query: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQK 175 LA S DG I + + + HT + V W Sbjct: 247 SKPRLASSSKDGTIKIWDTVSRVC---QYTMSGHTNSVSCVKW----------------- 286 Query: 176 PNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI----------- 224 SG D +++W + Q + L++H+ WV ++ + Sbjct: 287 -GGQGLLYSGSHDRTVRVWDI--NSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTG 343 Query: 225 ------------------------GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK 260 G + + S D +F+W ++ + Sbjct: 344 KKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKP---IARMTG 400 Query: 261 FNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 +V HV++S + + DN + LW DG++ IS SV Sbjct: 401 HQKLVNHVAFSPDGRYIVSASFDNSIKLWD-GRDGKF--ISTFRGHVASV 447 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H+ +++ G + + S D S+K++D R+G I+ RGH V+QVAW+ Sbjct: 399 TGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGK--FISTFRGHVASVYQVAWSSDC 456 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +L SCS D + +W + + GH V +V W+ G + G D + Sbjct: 457 --RLLVSCSKDTTLKVWDVRTRKL--SVDLPGHKDEVYTVDWSVD--GKRVCSGGKDKMV 510 Query: 130 SLLTY 134 L T+ Sbjct: 511 RLWTH 515 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 87/278 (31%), Gaps = 69/278 (24%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 V + H + + + G L + S DR+V+++D+ N I L+ H V + Sbjct: 269 VCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDI-NSQGRCINILKSHAHWVNHL 326 Query: 64 AWAHP----------------------------------MYGN---ILASCSYDRKVIIW 86 + + GN ++ + S D + +W Sbjct: 327 SLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLW 386 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 T + +GH VN V ++P G + S D +I L + Sbjct: 387 NPLKST-KPIARMTGHQKLVNHVAFSPD--GRYIVSASFDNSIKLWDGRDG---KFISTF 440 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 H V+W+ + + S D +K+W K Sbjct: 441 RGHVASVYQVAWS-----------------SDCRLLVSCSKDTTLKVWDV---RTRKLSV 480 Query: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 L H D V V W+ + + S +D V +WT Sbjct: 481 DLPGHKDEVYTVDWS----VDGKRVCSGGKDKMVRLWT 514 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 45/216 (20%), Positives = 76/216 (35%), Gaps = 33/216 (15%) Query: 99 HSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW 158 +GH S++ +APH ++ G+ D + + K H VSW Sbjct: 139 IAGHGSTILCSAFAPHTSSRMV-TGAGDNTARIWDCDTQTPMHTLK---GHYNWVLCVSW 194 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 +P + A+G DN I+LW + + L HS W+ + Sbjct: 195 SP-----------------DGEVIATGSMDNTIRLWDPKSGQCLGDA--LRGHSKWITSL 235 Query: 219 AWAPSI---GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITAN 275 +W P +AS S+DG + IW + + + V V W Sbjct: 236 SWEPIHLVKPGSKPRLASSSKDGTIKIWDT----VSRVCQYTMSGHTNSVSCVKWGGQG- 290 Query: 276 ILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 +L D V +W + G+ CI+ + V+ Sbjct: 291 LLYSGSHDRTVRVWDINSQGR--CINILKSHAHWVN 324 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 45/237 (18%), Positives = 80/237 (33%), Gaps = 35/237 (14%) Query: 92 TWEKTHEHSGHDSSVNSVCWAPHDYGLILACG---SSDGAISLLTYTGEGQWEVKKINNA 148 T+ T + V ++ + Y ++ G + D L T + + +++ Sbjct: 78 TFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSS 137 Query: 149 HTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKL 208 G + A P + + +G DN ++W + L Sbjct: 138 AIAGHGSTILCSAFAP------------HTSSRMVTGAGDNTARIWDCD---TQTPMHTL 182 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 + H +WV V+W+P IA+ S D + +W D SG L + + + Sbjct: 183 KGHYNWVLCVSWSPD----GEVIATGSMDNTIRLW--DPKSGQCLGDA-LRGHSKWITSL 235 Query: 269 SWSI-------TANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQ 318 SW + LA S D + +W VC ++ SVS GQ Sbjct: 236 SWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSR---VCQYTMSGHTNSVSCVKWGGQ 289 >6EMK-B nrPDB Length = 303 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 106/282 (37%), Gaps = 32/282 (11%) Query: 12 HEDM-IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D ++ ++ LAT ++V+++D+R +A GH G V V++ Sbjct: 30 HSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD-- 86 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + + S D + +W + + + ++ H++ VN V P+ LI DG I Sbjct: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPNQGELI--SCDRDGNIR 141 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + ++ ++S A GS++ + + Y+ + Sbjct: 142 IWDLGENQC--THQLTPEDDTSLQSLSMA---SDGSMLAAANTKGNCYVWEMP------- 189 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 + K K AHS ++ + + + +A+CS D +W+ DD Sbjct: 190 ----NHTDASHLKPVTKFRAHSTYITRILLSSDV----KHLATCSADHTARVWSIDD--- 238 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 + L VW ++S + L + D+ V LW S Sbjct: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 45/239 (18%), Positives = 81/239 (33%), Gaps = 28/239 (11%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + + T S D ++K++DVR+ I H PV +V HP Sbjct: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVI-HPNQ 128 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G L SC D + IW + + + G +LA ++ G Sbjct: 129 GE-LISCDRDGNIRIWDLGENQCTHQLTP---EDDTSLQSLSMASDGSMLAAANTKGNCY 184 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + +H + L+ + +K A+ D+ Sbjct: 185 VWEMPN-------HTDASHLKPVTKFRAHSTYITRILL-------SSDVKHLATCSADHT 230 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 ++W ++D +K E L+ H WV D A++ + + + S D V +W Sbjct: 231 ARVWSIDDD--FKLETTLDGHQRWVWDCAFSADS----AYLVTASSDHYVRLWDLSTRE 283 Score = 94.1 bits (232), Expect = 8e-20, Method: Composition-based stats. Identities = 41/283 (14%), Positives = 92/283 (32%), Gaps = 38/283 (13%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 L + D +++ ++ G + ++ + V ++ + +LA+ + + V ++ Sbjct: 4 ILVSAGYDHTIRFWEALTG--VCSRTIQHSDSQVNRLEITNDKK--LLATAGH-QNVRLY 58 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 GH +V SV + + + S DG I + N Sbjct: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNR--WMVTSSEDGTIKVWDVRSPSIPR----N 112 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 H N V P + S D I++W E+ + Sbjct: 113 YKHNAPVNEVVIHPNQ-----------------GELISCDRDGNIRIWDLGEN---QCTH 152 Query: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA--SGNMWSPKLLHKFNDV 264 +L D + S+ S +A+ + G ++W + + ++ + Sbjct: 153 QLTPEDDTSLQ---SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 Query: 265 VWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 + + S LA D+ +W S+D + + ++ Q Sbjct: 210 ITRILLSSDVKHLATCSADHTARVW--SIDDDFKLETTLDGHQ 250 Score = 66.8 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 40/101 (39%), Gaps = 5/101 (4%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H I + LATCS+D + +++ + + L L GH+ VW A++ Sbjct: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDD-DFKLETTLDGHQRWVWDCAFSADSA 263 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 L + S D V +W E ++ GH V Sbjct: 264 --YLVTASSDHYVRLWDLSTR--EIVRQYGGHHKGAVCVAL 300 Score = 44.4 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 24/62 (38%), Gaps = 2/62 (3%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 + T H+ + D L T SSD V+++D+ + ++ GH VA Sbjct: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST--REIVRQYGGHHKGAVCVA 299 Query: 65 WA 66 Sbjct: 300 LN 301 >5MZH-A nrPDB Length = 452 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 99/281 (35%), Gaps = 39/281 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H+ I + T +AT S D + K++DV G + A L GH + + + Sbjct: 177 GHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQER--ATLAGHRAEIVSLGFNT--G 232 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+++ + S+D +W G H SGH V+S + + G ++ GS D Sbjct: 233 GDLIVTGSFDHDSRLWDVRTGQC--VHVLSGHRGEVSSTQF--NYAGTLVVSGSIDCTSR 288 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 L VK HT V++ A K S D Sbjct: 289 LWDVRSGRCLSVK---QGHTDEVLDVAFDAAGT-----------------KMVSASADGS 328 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +L+ + L H + VA+ P + + + S D +W CD Sbjct: 329 ARLYH---TLTGVCQHTLVGHEGEISKVAFNP----QGTRLITASSDKTCRLWDCDTGE- 380 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 ++L D ++ +++ + + DN +WK Sbjct: 381 ---CLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 108/322 (33%), Gaps = 43/322 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H + + + G R T S DR+ K+++ G ++ L GH+ V+ +A+ +P Y Sbjct: 92 AHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF--TLEGHKNVVYAIAFNNP-Y 148 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ + + S+D+ +W G + + GH + + + + P I+A GS D Sbjct: 149 GDKIVTGSFDKTCKLWDAYTG--QLYYTLKGHQTEIVCLSFNP--QSTIIATGSMDNTAK 204 Query: 131 LLTYTGEGQWEVKKINNA--------------------HTIGCNAVS--WAPAVVPGSLI 168 L + + A H V V+ G Sbjct: 205 LWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRG 264 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 + S Q SG D +LW + + H+D V DVA+ Sbjct: 265 EVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVK---QGHTDEVLDVAFD----AAG 317 Query: 229 STIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288 + + S S DG ++ L + V+++ L + D L Sbjct: 318 TKMVSASADGSARLYHTLTG----VCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRL 373 Query: 289 WKESVDGQWVCISDVNKGQGSV 310 W C+ + + Sbjct: 374 WD---CDTGECLQVLEGHTDEI 392 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 49/242 (20%), Positives = 79/242 (32%), Gaps = 35/242 (14%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H I + G + T S D +++DVR G + L GH G V + Sbjct: 218 AGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ--CVHVLSGHRGEVSSTQFN--Y 273 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 G ++ S S D +W +G + GH V V + G + S+DG+ Sbjct: 274 AGTLVVSGSIDCTSRLWDVRSGRCLSVKQ--GHTDEVLDVAF--DAAGTKMVSASADGSA 329 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 L + H + V++ P + + D Sbjct: 330 RLYHTLTGVC---QHTLVGHEGEISKVAFNPQGT-----------------RLITASSDK 369 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 +LW + + Q LE H+D + A+ I + S+D IW AS Sbjct: 370 TCRLWDCD---TGECLQVLEGHTDEIFSCAF----NYEGDFIITGSKDNTCRIWKALTAS 422 Query: 250 GN 251 Sbjct: 423 SQ 424 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 8/126 (6%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 +V H D + D D GT++ + S+D S +++ G + L GHEG + +VA+ Sbjct: 299 SVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTG--VCQHTLVGHEGEISKVAFN 356 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 G L + S D+ +W + G + E GH + S + + G + GS D Sbjct: 357 P--QGTRLITASSDKTCRLWDCDTGECLQVLE--GHTDEIFSCAF--NYEGDFIITGSKD 410 Query: 127 GAISLL 132 + Sbjct: 411 NTCRIW 416 Score = 78.7 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 24/94 (25%), Positives = 40/94 (42%), Gaps = 4/94 (4%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 + V HE I + GTRL T SSD++ +++D G + L GH + Sbjct: 335 LTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTG--ECLQVLEGHTDEI 392 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWE 94 + A+ G+ + + S D IWK + + Sbjct: 393 FSCAFN--YEGDFIITGSKDNTCRIWKALTASSQ 424 Score = 29.8 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 4/39 (10%), Positives = 14/39 (35%) Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + K+L + + +++ + + D +W Sbjct: 83 SFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVW 121 >6F3T-A nrPDB Length = 608 Score = 168 bits (426), Expect = 2e-42, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 90/260 (34%), Gaps = 39/260 (15%) Query: 32 SSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENG 91 S D +I D + ++ I L GH GPV+ +++ N L S S D V +W + Sbjct: 328 SDDVLERIMDEKTASELKI--LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQTF 383 Query: 92 TWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTI 151 T + GH+ V ++P YG G D L ++ +I H Sbjct: 384 TC--LVGYKGHNYPVWDTQFSP--YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLA 436 Query: 152 GCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAH 211 N + P A+G D ++LW + H Sbjct: 437 DVNCTRFHPNS-----------------NYVATGSADRTVRLWDVLNGN---CVRIFTGH 476 Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS 271 + + ++P+ +A+ + DGRV +W L D V + +S Sbjct: 477 KGPIHSLTFSPN----GRFLATGATDGRVLLWDIGHG----LMVGELKGHTDTVCSLRFS 528 Query: 272 ITANILAVSGGDNKVTLWKE 291 ILA DN V LW Sbjct: 529 RDGEILASGSMDNTVRLWDA 548 Score = 141 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 46/235 (19%), Positives = 88/235 (37%), Gaps = 35/235 (14%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ A L + S D +V+++ ++ + +GH PVW ++ Y Sbjct: 349 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF--TCLVGYKGHNYPVWDTQFSP--Y 404 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G S +DR +W ++ +GH + VN + P+ +A GS+D + Sbjct: 405 GYYFVSGGHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPN--SNYVATGSADRTVR 460 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 L +I H ++++++P + A+G D Sbjct: 461 LWDVLNGNCV---RIFTGHKGPIHSLTFSP-----------------NGRFLATGATDGR 500 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 + LW G +L+ H+D V + ++ +AS S D V +W Sbjct: 501 VLLWDI---GHGLMVGELKGHTDTVCSLRFS----RDGEILASGSMDNTVRLWDA 548 Score = 122 bits (305), Expect = 2e-28, Method: Composition-based stats. Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 8/127 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H ++ + +AT S+DR+V+++DV NG + I GH+GP+ + ++ Sbjct: 432 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--FTGHKGPIHSLTFSP-- 487 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 G LA+ + D +V++W +G E GH +V S+ ++ G ILA GS D + Sbjct: 488 NGRFLATGATDGRVLLWDIGHGLM--VGELKGHTDTVCSLRFSRD--GEILASGSMDNTV 543 Query: 130 SLLTYTG 136 L Sbjct: 544 RLWDAIK 550 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 44/292 (15%), Positives = 90/292 (30%), Gaps = 53/292 (18%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 + + +A +D +V+++ V + ++ ++L Sbjct: 284 VDVTDDSSLIAGGFADSTVRVWSVTPKKLRSV-------KQASDLSLIDKESDDVLE--- 333 Query: 79 YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 I E+ + K GH V ++P L S DG + L + Sbjct: 334 -----RIMDEKTASELKI--LYGHSGPVYGASFSPDRN--YLLSSSEDGTVRLWSLQ--- 381 Query: 139 QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEE 198 + H ++P Y F SGG D + +LW Sbjct: 382 TFTCLVGYKGHNYPVWDTQFSP-----------------YGYYFVSGGHDRVARLWA--- 421 Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 ++ + H V + P+ +A+ S D V +W + + ++ Sbjct: 422 TDHYQPLRIFAGHLADVNCTRFHPNSN----YVATGSADRTVRLWDVLNGN----CVRIF 473 Query: 259 HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 + +++S LA D +V LW G + + ++ +V Sbjct: 474 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI---GHGLMVGELKGHTDTV 522 >6MZM-G nrPDB Length = 800 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 81/239 (33%), Gaps = 37/239 (15%) Query: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWA 112 L GH GPV+ +++ N L S S D V +W + T + GH+ V ++ Sbjct: 539 LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQTFTC--LVGYKGHNYPVWDTQFS 594 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P YG G D L ++ +I H N + P Sbjct: 595 P--YGYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNS---------- 639 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 A+G D ++LW + H + + ++P+ +A Sbjct: 640 -------NYVATGSADRTVRLWDVLNGN---CVRIFTGHKGPIHSLTFSPN----GRFLA 685 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 + + DGRV +W L D V + +S ILA DN V LW Sbjct: 686 TGATDGRVLLWDIGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 46/235 (19%), Positives = 88/235 (37%), Gaps = 35/235 (14%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ A L + S D +V+++ ++ + +GH PVW ++ Y Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF--TCLVGYKGHNYPVWDTQFSP--Y 596 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G S +DR +W ++ +GH + VN + P+ +A GS+D + Sbjct: 597 GYYFVSGGHDRVARLW--ATDHYQPLRIFAGHLADVNCTRFHPN--SNYVATGSADRTVR 652 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 L +I H ++++++P + A+G D Sbjct: 653 LWDVLNGNCV---RIFTGHKGPIHSLTFSP-----------------NGRFLATGATDGR 692 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 + LW G +L+ H+D V + ++ +AS S D V +W Sbjct: 693 VLLWDI---GHGLMVGELKGHTDTVCSLRFS----RDGEILASGSMDNTVRLWDA 740 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 8/127 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H ++ + +AT S+DR+V+++DV NG + I GH+GP+ + ++ Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--FTGHKGPIHSLTFSP-- 679 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 G LA+ + D +V++W +G E GH +V S+ ++ G ILA GS D + Sbjct: 680 NGRFLATGATDGRVLLWDIGHGLM--VGELKGHTDTVCSLRFSRD--GEILASGSMDNTV 735 Query: 130 SLLTYTG 136 L Sbjct: 736 RLWDAIK 742 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 36/212 (16%), Positives = 67/212 (31%), Gaps = 36/212 (16%) Query: 99 HSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW 158 GH V ++P L S DG + L + + H + Sbjct: 539 LYGHSGPVYGASFSPDRN--YLLSSSEDGTVRLWSLQ---TFTCLVGYKGHNYPVWDTQF 593 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 +P Y F SGG D + +LW ++ + H V Sbjct: 594 SP-----------------YGYYFVSGGHDRVARLWA---TDHYQPLRIFAGHLADVNCT 633 Query: 219 AWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILA 278 + P+ +A+ S D V +W + + ++ + +++S LA Sbjct: 634 RFHPNSN----YVATGSADRTVRLWDVLNGN----CVRIFTGHKGPIHSLTFSPNGRFLA 685 Query: 279 VSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 D +V LW G + + ++ +V Sbjct: 686 TGATDGRVLLWDI---GHGLMVGELKGHTDTV 714 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 35/115 (30%), Gaps = 11/115 (9%) Query: 206 QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVV 265 + L HS V +++P + + S S+DG V +W+ N V Sbjct: 537 KILYGHSGPVYGASFSPD----RNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPV 588 Query: 266 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQN 320 W +S G D LW + + V+ + N Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWA---TDHYQPLRIFAGHLADVNCTRFHPNSN 640 >5NNZ-B nrPDB Length = 415 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 107/303 (35%), Gaps = 42/303 (13%) Query: 11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H ++++ + YG ++AT S D++ K++ V G RGH + +++ Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--CYHTFRGHTAEIVCLSFNP-- 187 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 ++A+ S D +W +NG E+ + GH + + S+ + + G + GS D + Sbjct: 188 QSTLVATGSMDTTAKLWDIQNG--EEVYTLRGHSAEIISLSF--NTSGDRIITGSFDHTV 243 Query: 130 SLLTYTGEGQWEVKKINNA----------------------HTIGCNAVSWAPAVVPGSL 167 + + + + A + A + G Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303 Query: 168 IDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP 227 + K A+ D +++ K KLE H + +++ P Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFS---AATRKCIAKLEGHEGEISKISFNP----Q 356 Query: 228 TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 287 + + + S D IW ++L D ++ +++ NI+ DN Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQ----CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412 Query: 288 LWK 290 +W+ Sbjct: 413 IWR 415 Score = 160 bits (404), Expect = 7e-40, Method: Composition-based stats. Identities = 60/318 (18%), Positives = 110/318 (34%), Gaps = 43/318 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H + + ++ G+ T S DR+ K++D +G + + L GH V+ +A+ +P Y Sbjct: 90 AHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEE--LNTLEGHRNVVYAIAFNNP-Y 146 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ +A+ S+D+ +W E G H GH + + + + P ++A GS D Sbjct: 147 GDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNP--QSTLVATGSMDTTAK 202 Query: 131 LLTYTGEGQWEVKKINNAH----------------TIGCNAVSWA------PAVVPGSLI 168 L + + ++A + V W ++ G Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 + S +G D KLW + K L H D + D + Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLTGHDDEILDSCFD----YTG 315 Query: 229 STIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288 IA+ S DG I++ L + +S++ N L D + Sbjct: 316 KLIATASADGTARIFSAATRK----CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371 Query: 289 WKESVDGQWVCISDVNKG 306 W C+ + Sbjct: 372 WDAQTG---QCLQVLEGH 386 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 8/124 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H+D I D+ DY G +AT S+D + +IF + IA L GHEG + ++++ Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIF--SAATRKCIAKLEGHEGEISKISFNP-- 355 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 GN L + S D+ IW + G + E GH + S + + G I+ GS D Sbjct: 356 QGNHLLTGSSDKTARIWDAQTGQCLQVLE--GHTDEIFSCAF--NYKGNIVITGSKDNTC 411 Query: 130 SLLT 133 + Sbjct: 412 RIWR 415 Score = 28.6 bits (62), Expect = 3.4, Method: Composition-based stats. Identities = 6/44 (13%), Positives = 17/44 (38%) Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 +++ + K+L + +V+ + + + D LW Sbjct: 77 NSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 120 >5M25-A nrPDB Length = 434 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 104/306 (33%), Gaps = 41/306 (13%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + + G LA+ S+D+ +KI+ +G + GH+ + VAW+ Sbjct: 142 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD- 198 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N+L S S D+ + IW +G KT GH + V + P ++ GS D ++ Sbjct: 199 -SNLLVSASDDKTLKIWDVSSGKCLKT--LKGHSNYVFCCNFNP--QSNLIVSGSFDESV 253 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID-------------------- 169 + + ++ + +V S Sbjct: 254 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 313 Query: 170 ---QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 + K + DN +KLW + K + H + + +A Sbjct: 314 NPPVSFVKFSPNGKYILAATLDNTLKLWDY---SKGKCLKTYTGHKNEKYCI-FANFSVT 369 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG--DN 284 I S S+D V+IW + L DVV + T NI+A + D Sbjct: 370 GGKWIVSGSEDNLVYIWNLQTKE----IVQKLQGHTDVVISTACHPTENIIASAALENDK 425 Query: 285 KVTLWK 290 + LWK Sbjct: 426 TIKLWK 431 Score = 158 bits (398), Expect = 4e-39, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 96/263 (36%), Gaps = 39/263 (14%) Query: 45 GGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDS 104 L L GH V V ++ G LAS S D+ + IW +G +EKT SGH Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKL 188 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 ++ V W+ +L S D + + + + K ++ + CN + Sbjct: 189 GISDVAWSSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL--- 243 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 SG D +++W + K + L AHSD V V + Sbjct: 244 -----------------IVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHF---- 279 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 S I S S DG IW D ASG L+ N V V +S + + DN Sbjct: 280 NRDGSLIVSSSYDGLCRIW--DTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDN 336 Query: 285 KVTLWKESVDGQWVCISDVNKGQ 307 + LW S + C+ + Sbjct: 337 TLKLWDYS---KGKCLKTYTGHK 356 Score = 44.1 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 23/75 (30%), Gaps = 3/75 (4%) Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 N L V V +S LA S D + +W DG++ ++ Sbjct: 129 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFE--KTISG 185 Query: 306 GQGSVSASITEGQQN 320 + +S N Sbjct: 186 HKLGISDVAWSSDSN 200 >5FVM-C nrPDB Length = 303 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 51/284 (17%), Positives = 106/284 (37%), Gaps = 32/284 (11%) Query: 12 HEDM-IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D ++ ++ LA V+++D+R+ ++ GH+G V +A+ Sbjct: 30 HADSQVNRLEITSDKKYLAAAG-HLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQ--QE 86 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S S D + +W + + ++ ++ H++ VN V P+ LI DG I Sbjct: 87 NRWMVSSSEDGTIKVWDVRSPSVQRNYK---HNAPVNEVAIHPNQGELI--SCDQDGNIR 141 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + ++ ++S A GS++ + + Y+ + Sbjct: 142 IWDLGENQCTN--QLTPEDNTPLQSLSVA---SDGSMLVAGNNKGNCYVWRMP------- 189 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 + + K ++H+ ++ V + + +A+CS D +W +D Sbjct: 190 ----HHTDASTLEPVTKFKSHTKYITRVLLSADVKN----LATCSADHTARVWNIED--- 238 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 N L VW ++S + L + D+ V LW S Sbjct: 239 NYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTS 282 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 47/242 (19%), Positives = 87/242 (35%), Gaps = 34/242 (14%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H+ + + + S D ++K++DVR+ + H PV +VA HP Sbjct: 73 GHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS---VQRNYKHNAPVNEVAI-HPNQ 128 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G L SC D + IW ++ + S+ A G +L G++ G Sbjct: 129 GE-LISCDQDGNIRIWDLGENQCTNQLTPED-NTPLQSLSVASD--GSMLVAGNNKGNCY 184 Query: 131 LLT---YTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + +T E +HT V + +K A+ Sbjct: 185 VWRMPHHTDASTLEPVTKFKSHTKYITRVLLS-----------------ADVKNLATCSA 227 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D+ ++W E++ ++ E L+ H WV D A++ + + + D V +W Sbjct: 228 DHTARVWNIEDN--YQLETTLDGHQRWVWDCAFSADS----AYLVTACSDHYVRLWDLST 281 Query: 248 AS 249 + Sbjct: 282 SE 283 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 5/101 (4%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 SH I + LATCS+D + +++++ + L L GH+ VW A++ Sbjct: 205 SHTKYITRVLLSADVKNLATCSADHTARVWNIED-NYQLETTLDGHQRWVWDCAFSADSA 263 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 L + D V +W T E ++ GH V Sbjct: 264 --YLVTACSDHYVRLWDLS--TSEIVRQYGGHHKGAVCVAL 300 Score = 57.5 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 27/193 (13%), Positives = 53/193 (27%), Gaps = 34/193 (17%) Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +ILA D I + ++ + + Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQV---------------------NRLEI 40 Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 KK+ + ++L+ + E H V +A+ + S S+ Sbjct: 41 TSDKKYLAAAGHLHVRLYDIRSNNP-NPVSSFEGHKGNVTSIAF----QQENRWMVSSSE 95 Query: 237 DGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 DG + +W S +K N V V+ L D + +W G+ Sbjct: 96 DGTIKVWDVRSPSVQ-----RNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDL---GE 147 Query: 297 WVCISDVNKGQGS 309 C + + + Sbjct: 148 NQCTNQLTPEDNT 160 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 22/62 (35%), Gaps = 2/62 (3%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 + T H+ + D L T SD V+++D+ ++ GH VA Sbjct: 242 LETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTS--EIVRQYGGHHKGAVCVA 299 Query: 65 WA 66 Sbjct: 300 LN 301 >2H9P-A nrPDB Length = 329 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 104/306 (33%), Gaps = 41/306 (13%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + + G LA+ S+D+ +KI+ +G + GH+ + VAW+ Sbjct: 37 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSD- 93 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N+L S S D+ + IW +G KT GH + V + P ++ GS D ++ Sbjct: 94 -SNLLVSASDDKTLKIWDVSSGKCLKT--LKGHSNYVFCCNFNP--QSNLIVSGSFDESV 148 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID-------------------- 169 + + ++ + +V S Sbjct: 149 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 208 Query: 170 ---QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 + K + DN +KLW + K + H + + +A Sbjct: 209 NPPVSFVKFSPNGKYILAATLDNTLKLWDY---SKGKCLKTYTGHKNEKYCI-FANFSVT 264 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG--DN 284 I S S+D V+IW + L DVV + T NI+A + D Sbjct: 265 GGKWIVSGSEDNLVYIWNLQTKE----IVQKLQGHTDVVISTACHPTENIIASAALENDK 320 Query: 285 KVTLWK 290 + LWK Sbjct: 321 TIKLWK 326 Score = 151 bits (381), Expect = 3e-37, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 96/263 (36%), Gaps = 39/263 (14%) Query: 45 GGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDS 104 L L GH V V ++ G LAS S D+ + IW +G +EKT SGH Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKL 83 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 ++ V W+ +L S D + + + + K ++ + CN + Sbjct: 84 GISDVAWSSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL--- 138 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 SG D +++W + K + L AHSD V V + Sbjct: 139 -----------------IVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHF---- 174 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 S I S S DG IW D ASG L+ N V V +S + + DN Sbjct: 175 NRDGSLIVSSSYDGLCRIW--DTASGQCLK-TLIDDDNPPVSFVKFSPNGKYILAATLDN 231 Query: 285 KVTLWKESVDGQWVCISDVNKGQ 307 + LW S + C+ + Sbjct: 232 TLKLWDYS---KGKCLKTYTGHK 251 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 23/75 (30%), Gaps = 3/75 (4%) Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 N L V V +S LA S D + +W DG++ ++ Sbjct: 24 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFE--KTISG 80 Query: 306 GQGSVSASITEGQQN 320 + +S N Sbjct: 81 HKLGISDVAWSSDSN 95 >5WYJ-BC nrPDB Length = 817 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 100/298 (33%), Gaps = 46/298 (15%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL--IADLRGHEGPVWQVA 64 + HED+++ G +AT S D + ++ A GH V V Sbjct: 382 EIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVG 441 Query: 65 WAH---PMYGNILASCSYDRKVIIWKEENGTW--------EKTHEHSGHDSSVNSVCWAP 113 + Y L + S D + W T + H+ +N++ +P Sbjct: 442 LPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 +D I A S D + E++ H G VS+ Sbjct: 502 NDS--IFATASYDKTCKIWNLENG---ELEATLANHKRGLWDVSFC-------------- 542 Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 Y K A+ D +K+W + + + LE H++ V+ ++ + S Sbjct: 543 ---QYDKLLATSSGDKTVKIWSLD---TFSVMKTLEGHTNAVQRCSF----INKQKQLIS 592 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 C DG + IW C K L N+ +W +S +++ + D WK+ Sbjct: 593 CGADGLIKIWDCSSGE----CLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKD 646 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 78/196 (39%), Gaps = 28/196 (14%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 ++ V +HE I+ + + AT S D++ KI+++ NG L A L H+ + Sbjct: 479 IIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENG--ELEATLANHKRGL 536 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 W V++ Y +LA+ S D+ V IW + + KT E GH ++V + LI Sbjct: 537 WDVSFC--QYDKLLATSSGDKTVKIWSLDTFSVMKTLE--GHTNAVQRCSFINKQKQLI- 591 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 +DG I + + + G N WA + + + Sbjct: 592 -SCGADGLIKIWDCSSGECLKTLD-------GHNNRLWALSTMNDGDM------------ 631 Query: 181 KFASGGCDNLIKLWRE 196 S D + + W++ Sbjct: 632 -IVSADADGVFQFWKD 646 Score = 91.4 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 102/297 (34%), Gaps = 44/297 (14%) Query: 33 SDRSVKIFDVRNGGQ------ILIADLRGHEGPVWQVAWAHPMYGNI-LASCSYDRKVI- 84 SD+++++ +V + + + + G+ G + + + P + LA+ S ++I Sbjct: 307 SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIP 366 Query: 85 IWKEENGT---WEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY-TGEGQW 140 + + GH+ +NS+ + GL +A S D + Y ++ Sbjct: 367 VPDLSGPEASLPLDVEIYEGHEDLLNSLD--ATEDGLWIATASKDNTAIVWRYNENSCKF 424 Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDG 200 ++ H+ AV P+ Y + + D IK W + Sbjct: 425 DIYAKYIGHSAAVTAV------------GLPNIVSKGYPEFLLTASNDLTIKKWIIPKPT 472 Query: 201 Q-------WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMW 253 E AH + ++ +P+ S A+ S D IW ++ Sbjct: 473 ASMDVQIIKVSEYTRHAHEKDINALSVSPN----DSIFATASYDKTCKIWNLENGELE-- 526 Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 L +W VS+ +LA S GD V +W + + + +V Sbjct: 527 --ATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSL---DTFSVMKTLEGHTNAV 578 Score = 71.8 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 73/203 (35%), Gaps = 37/203 (18%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 +++ + E I ++ G L S + +KIF ++ G V + Sbjct: 52 ILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKV------------VRSM 99 Query: 64 AWAHPMY-------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP--H 114 + P Y +LA D +I+ ENG TH GH +++S+ + + Sbjct: 100 KISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYI--THSFKGHGGTISSLKFYGQLN 157 Query: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQ 174 +LA G ++G + + + + + G + + VP + + Sbjct: 158 SKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDII-----EVPDNDEPSLN-- 210 Query: 175 KPNYIKKFASGGCDNLIKLWREE 197 SGG D++I LW Sbjct: 211 -------LLSGGRDDIINLWDFN 226 Score = 62.2 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 44/318 (13%), Positives = 98/318 (30%), Gaps = 36/318 (11%) Query: 11 SHEDMIHDAQMDYYGTR------LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 H I + YG LA+ ++ VK++D+ + + L+ H V + Sbjct: 142 GHGGTISSLKF--YGQLNSKIWLLASGDTNGMVKVWDL--VKRKCLHTLQEHTSAVRGLD 197 Query: 65 WA----HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGL-I 119 + L S D + +W K + + V S + G I Sbjct: 198 IIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRI 257 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 + D L+ + + V+P Q + Sbjct: 258 IYTAGGDAIFQLIDSESGSVLKRTNKPIEE-------LFIIGVLPILSNSQMFLVLSDQT 310 Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 + + D L +E+ Q + + + D+ + +G + +A + Sbjct: 311 LQLINVEED----LKNDEDTIQ--VTSSIAGNHGIIADMRY---VGPELNKLALATNSPS 361 Query: 240 VFIWTCDDASGNM----WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 295 + I D SG ++ D++ + + +A + DN +W+ + + Sbjct: 362 LRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENS 421 Query: 296 -QWVCISDVNKGQGSVSA 312 ++ + +V+A Sbjct: 422 CKFDIYAKYIGHSAAVTA 439 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 68/233 (29%), Gaps = 40/233 (17%) Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGH-DSSVNSVCWAPHDYGLILACGSSDG 127 G ILA+ D + I G+ + H+ S + + ++ P G L S Sbjct: 27 ENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEITALKLTPD--GQYLTYVSQAQ 83 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + KI P ++D S A GG Sbjct: 84 LLKIFHLKTGKVVRSMKI----------------SSPSYILDADSTST-----LLAVGGT 122 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D I + E + H + + + + +AS +G V +W Sbjct: 123 DGSIIVVDIENG---YITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDL-- 177 Query: 248 ASGNMWSPKLLHKFNDVVWHVSW-------SITANILAVSGGDNKVTLWKESV 293 L + V + + N+L G D+ + LW ++ Sbjct: 178 --VKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLL-SGGRDDIINLWDFNM 227 >6HQA-B nrPDB Length = 722 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 99/298 (33%), Gaps = 57/298 (19%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI-------------------ADL 53 + + + + T +A+ D +K++ + + L Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRL 449 Query: 54 RGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP 113 GH G V+ V ++ L SCS D+ V +W + T + GH SSV V ++P Sbjct: 450 VGHSGAVYGVDFSPD--NRYLISCSEDKTVRLWSLDTYTC--LVSYKGHSSSVWDVKFSP 505 Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 G A S D L + +I H + V + P Sbjct: 506 M--GHYFATASHDQTARLWSC---DHIYPLRIFAGHLNDVDCVEFHPNST---------- 550 Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 +G D ++W + + + HS + +A +P +AS Sbjct: 551 -------YLFTGSSDKTARMWDI---ARGECVRVFMGHSGAINCLAVSPD----GRWLAS 596 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLLHKF-NDVVWHVSWSITANILAVSGGDNKVTLWK 290 +D V +W K + ++ +++S +L +G DN V +W Sbjct: 597 AGEDSVVCLWDISTG----RRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWD 650 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 89/237 (37%), Gaps = 36/237 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ L +CS D++V+++ + + +GH VW V ++ Sbjct: 451 GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT--YTCLVSYKGHSSSVWDVKFSP--M 506 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ A+ S+D+ +W ++ + +GH + V+ V + P+ L GSSD Sbjct: 507 GHYFATASHDQTARLWSCDHIYPLRI--FAGHLNDVDCVEFHPN--STYLFTGSSDKTAR 562 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + E ++ H+ N ++ +P + AS G D++ Sbjct: 563 MWDIARG---ECVRVFMGHSGAINCLAVSP-----------------DGRWLASAGEDSV 602 Query: 191 IKLWREEEDGQWKEEQKLEAH-SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 + LW + + + H + +A++ + + S D V +W Sbjct: 603 VCLWDI---STGRRIKAMRGHGRSSIYSLAFS----REGTVLVSTGADNSVRVWDVK 652 Score = 111 bits (278), Expect = 3e-25, Method: Composition-based stats. Identities = 40/290 (13%), Positives = 82/290 (28%), Gaps = 54/290 (18%) Query: 48 ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTH---------- 97 + + + + + ++AS D + +W + Sbjct: 381 VCMYTFHNTNNDLTCLKFNDD--STMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNN 438 Query: 98 ---------EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNA 148 GH +V V ++P + L S D + L + + Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNR--YLISCSEDKTVRLWSL---DTYTCLVSYKG 493 Query: 149 HTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKL 208 H+ V ++P FA+ D +LW + + Sbjct: 494 HSSSVWDVKFSPMGH-----------------YFATASHDQTARLWSCD---HIYPLRIF 533 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 H + V V + P+ + + + S D +W ++ + + + Sbjct: 534 AGHLNDVDCVEFHPNS----TYLFTGSSDKTARMWDIARGE----CVRVFMGHSGAINCL 585 Query: 269 SWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQ 318 + S LA +G D+ V LW S + + + A EG Sbjct: 586 AVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGT 635 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 53/129 (41%), Gaps = 9/129 (6%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + + + T L T SSD++ +++D+ G + GH G + +A + Sbjct: 534 AGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARG--ECVRVFMGHSGAINCLAVSPD- 590 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGH-DSSVNSVCWAPHDYGLILACGSSDGA 128 G LAS D V +W G K GH SS+ S+ ++ G +L +D + Sbjct: 591 -GRWLASAGEDSVVCLWDISTGRRIKAMR--GHGRSSIYSLAFS--REGTVLVSTGADNS 645 Query: 129 ISLLTYTGE 137 + + Sbjct: 646 VRVWDVKKN 654 Score = 74.1 bits (180), Expect = 7e-14, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 39/89 (43%), Gaps = 5/89 (5%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGH-EGPVWQVAWAHPM 69 H I+ + G LA+ D V ++D+ G + I +RGH ++ +A++ Sbjct: 577 GHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRR--IKAMRGHGRSSIYSLAFSR-- 632 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHE 98 G +L S D V +W + T + + Sbjct: 633 EGTVLVSTGADNSVRVWDVKKNTNSPSAQ 661 >5Z56-q nrPDB Length = 504 Score = 153 bits (387), Expect = 7e-38, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 41/290 (14%) Query: 23 YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRK 82 ++ T +D++V +FD + ++A L+GH V V + HP ++ S S D Sbjct: 232 SDTNKILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVF-HPSQD-LVFSASPDAT 287 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 + IW N + + H+S+V + H G L S D + G+ Sbjct: 288 IRIWSVPNASCVQVVR--AHESAVTGLSL--HATGDYLLSSSDDQ-YWAFSDIQTGRVLT 342 Query: 143 KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQW 202 K + + P + F +G D+ IK+W +E Sbjct: 343 KVTDETSGCSLTCAQFHPDGLI-----------------FGTGTMDSQIKIWDLKERTN- 384 Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 HS + +A++ + +A+ + D V +W N + +L + F Sbjct: 385 --VANFPGHSGPITSIAFSEN----GYYLATAADDSSVKLWDLR-KLKNFKTLQLDNNFE 437 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSA 312 V + + + LA+ G D ++ + K QW I + G + Sbjct: 438 --VKSLIFDQSGTYLALGGTDVQIYICK-----QWTEILHFTEHSGLTTG 480 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 85/279 (30%), Gaps = 38/279 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + + + S D +++I+ V N + +R HE V ++ Sbjct: 262 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS--CVQVVRAHESAVTGLSLH--AT 317 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ L S S D+ + G S+ + P GLI G+ D I Sbjct: 318 GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD--GLIFGTGTMDSQIK 375 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + A PG S A+ D+ Sbjct: 376 IWDLKE--------------------RTNVANFPGHSGPITSIAFSENGYYLATAADDSS 415 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +KLW + +K Q V+ + + S + +A D +++I Sbjct: 416 VKLWDLRKLKNFKTLQLDNNFE--VKSLIFDQS----GTYLALGGTDVQIYI------CK 463 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + + + V++ A +A +G D + + Sbjct: 464 QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 Score = 92.6 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 34/252 (13%), Positives = 75/252 (29%), Gaps = 42/252 (16%) Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 P N + + D+ V+++ + + GH V SV + P ++ S D Sbjct: 230 CPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHPSQD--LVFSASPD 285 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + + +V AH +S + Sbjct: 286 ATIRIWSVPNASCVQVV---RAHESAVTGLSLHA------------------TGDYLLSS 324 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D+ + + + G+ + E + + P + + D ++ IW Sbjct: 325 SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD----GLIFGTGTMDSQIKIWDLK 380 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES---------VDGQW 297 + + + + +++S LA + D+ V LW +D + Sbjct: 381 ER----TNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 436 Query: 298 VCISDVNKGQGS 309 S + G+ Sbjct: 437 EVKSLIFDQSGT 448 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 79/238 (33%), Gaps = 34/238 (14%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 V +HE + + G L + S D+ D++ G + + + Sbjct: 301 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 360 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 G I + + D ++ IW + T GH + S+ ++ + G LA + D Sbjct: 361 D--GLIFGTGTMDSQIKIWDLKERT--NVANFPGHSGPITSIAFS--ENGYYLATAADDS 414 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 ++ L ++ +++N ++ + + A GG Sbjct: 415 SVKLWDLRKLKNFKTLQLDNN--FEVKSLIFDQSGT-----------------YLALGGT 455 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 D I + + QW E HS VA+ G IAS D + ++ Sbjct: 456 DVQIYICK-----QWTEILHFTEHSGLTTGVAF----GHHAKFIASTGMDRSLKFYSL 504 >3DM0-A nrPDB Length = 694 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 100/291 (34%), Gaps = 38/291 (13%) Query: 4 VINTVDTSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL---IADLRGHEGP 59 V+ +H DM+ + + S D+S+ ++ + + L GH Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 V V + G S S+D ++ +W G T GH V SV ++ + Sbjct: 433 VEDVVLSSD--GQFALSGSWDGELRLWDLAAG--VSTRRFVGHTKDVLSVAFSLDNRQ-- 486 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 + S D I L GE ++ + + H + V ++P + Sbjct: 487 IVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQP-------------- 532 Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 S D +K+W K L H+ +V VA +P S AS +DG Sbjct: 533 -TIVSASWDKTVKVWNL---SNCKLRSTLAGHTGYVSTVAVSPD----GSLCASGGKDGV 584 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 V +W + N V+ + +S L + ++ + +W Sbjct: 585 VLLWDLAEGKKLYSLEA-----NSVIHALCFSPNRYWLCAA-TEHGIKIWD 629 Score = 133 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 48/302 (15%), Positives = 99/302 (32%), Gaps = 49/302 (16%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 V T H + D + G + S D ++++D+ G + GH V V Sbjct: 421 VAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAG--VSTRRFVGHTKDVLSV 478 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENG-TWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 A++ + + S S DR + +W + + GH V+ V ++P+ + Sbjct: 479 AFS--LDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVS 536 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 S D + + + +++ HT + V+ +P Sbjct: 537 ASWDKTVKVWNLSN---CKLRSTLAGHTGYVSTVAVSP-----------------DGSLC 576 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 ASGG D ++ LW E + + + + + ++P+ + + + I Sbjct: 577 ASGGKDGVVLLWDLAEGKKLYSLEA----NSVIHALCFSPN-----RYWLCAATEHGIKI 627 Query: 243 WTCDDASGNMWSPKLLHKFND---------------VVWHVSWSITANILAVSGGDNKVT 287 W + S L + ++WS + L D + Sbjct: 628 WDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIR 687 Query: 288 LW 289 +W Sbjct: 688 VW 689 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 63/216 (29%), Gaps = 29/216 (13%) Query: 98 EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157 H V ++ P D I+ S D +I L T + + + G + Sbjct: 377 TMRAHTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDD--KAYGVAQRRLTGHSHFV 433 Query: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 + SG D ++LW ++ H+ V Sbjct: 434 EDVVLSSDGQFA-------------LSGSWDGELRLWDL---AAGVSTRRFVGHTKDVLS 477 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITA--N 275 VA++ L I S S+D + +W + D V V +S Sbjct: 478 VAFS----LDNRQIVSASRDRTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQP 532 Query: 276 ILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 + + D V +W S S + G VS Sbjct: 533 TIVSASWDKTVKVWNLS---NCKLRSTLAGHTGYVS 565 >4LG8-A nrPDB Length = 354 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 41/290 (14%) Query: 23 YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRK 82 ++ T +D++V +FD + ++A L+GH V V + HP ++ S S D Sbjct: 82 SDTNKILTGGADKNVVVFDKS--SEQILATLKGHTKKVTSVVF-HPSQD-LVFSASPDAT 137 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 + IW N + + H+S+V + H G L S D + G+ Sbjct: 138 IRIWSVPNASCVQVVR--AHESAVTGLSL--HATGDYLLSSSDDQ-YWAFSDIQTGRVLT 192 Query: 143 KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQW 202 K + + P + F +G D+ IK+W +E Sbjct: 193 KVTDETSGCSLTCAQFHPDGLI-----------------FGTGTMDSQIKIWDLKERTN- 234 Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 HS + +A++ + +A+ + D V +W N + +L + F Sbjct: 235 --VANFPGHSGPITSIAFSEN----GYYLATAADDSSVKLWDLR-KLKNFKTLQLDNNFE 287 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSA 312 V + + + LA+ G D ++ + K QW I + G + Sbjct: 288 --VKSLIFDQSGTYLALGGTDVQIYICK-----QWTEILHFTEHSGLTTG 330 Score = 92.6 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 84/279 (30%), Gaps = 38/279 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + + + S D +++I+ V N + +R HE V ++ Sbjct: 112 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS--CVQVVRAHESAVTGLSLH--AT 167 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+ L S S D+ + G S+ + P GLI G+ D I Sbjct: 168 GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD--GLIFGTGTMDSQIK 225 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + A PG S A+ D+ Sbjct: 226 IWDLKE--------------------RTNVANFPGHSGPITSIAFSENGYYLATAADDSS 265 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +KLW + +K Q V+ + + + +A D +++I Sbjct: 266 VKLWDLRKLKNFKTLQLDNNFE--VKSLIFD----QSGTYLALGGTDVQIYI------CK 313 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + + + V++ A +A +G D + + Sbjct: 314 QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 352 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 34/252 (13%), Positives = 75/252 (29%), Gaps = 42/252 (16%) Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 P N + + D+ V+++ + + GH V SV + P ++ S D Sbjct: 80 CPSDTNKILTGGADKNVVVFDKSSEQI--LATLKGHTKKVTSVVFHPSQD--LVFSASPD 135 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + + +V AH +S + Sbjct: 136 ATIRIWSVPNASCVQVV---RAHESAVTGLSLHA------------------TGDYLLSS 174 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D+ + + + G+ + E + + P + + D ++ IW Sbjct: 175 SDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD----GLIFGTGTMDSQIKIWDLK 230 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES---------VDGQW 297 + + + + +++S LA + D+ V LW +D + Sbjct: 231 ER----TNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNF 286 Query: 298 VCISDVNKGQGS 309 S + G+ Sbjct: 287 EVKSLIFDQSGT 298 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 79/238 (33%), Gaps = 34/238 (14%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 V +HE + + G L + S D+ D++ G + + + Sbjct: 151 VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP 210 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 G I + + D ++ IW + T GH + S+ ++ + G LA + D Sbjct: 211 D--GLIFGTGTMDSQIKIWDLKERT--NVANFPGHSGPITSIAFS--ENGYYLATAADDS 264 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 ++ L ++ +++N ++ + + A GG Sbjct: 265 SVKLWDLRKLKNFKTLQLDNN--FEVKSLIFDQSGT-----------------YLALGGT 305 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 D I + + QW E HS VA+ G IAS D + ++ Sbjct: 306 DVQIYICK-----QWTEILHFTEHSGLTTGVAF----GHHAKFIASTGMDRSLKFYSL 354 >4BTS-AR nrPDB Length = 343 Score = 147 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 93/253 (36%), Gaps = 43/253 (16%) Query: 53 LRGHEGPVWQVA--WAHPMYGN--ILASCSYDRKVIIWK----EENGTWEKTHE-HSGHD 103 L GH V + ++ + +L S S D+ V+IWK E+NG + H+ +GH+ Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 104 SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 V+ + + S D + L +G + ++ A Sbjct: 77 HFVSDLALS--QENCFAISSSWDKTLRLWDLRTG-------TTYKRFVGHQSEVYSVAFS 127 Query: 164 PGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 P + ++ S G + IKLW + ++ +K E HSDWV V ++P Sbjct: 128 PDN-------------RQILSAGAEREIKLWNILGECKFSSAEK-ENHSDWVSCVRYSPI 173 Query: 224 IGLPTS------TIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 + AS DGR+ +W N V H+S S + Sbjct: 174 MKSANKVQPFAPYFASVGWDGRLKVWNT-----NFQIRYTFKAHESNVNHLSISPNGKYI 228 Query: 278 AVSGGDNKVTLWK 290 A G D K+ +W Sbjct: 229 ATGGKDKKLLIWD 241 Score = 132 bits (331), Expect = 2e-31, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 113/298 (37%), Gaps = 38/298 (12%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTR------LATCSSDRSVKIFDVRNGGQ-----ILIA 51 V + H D + + L + S D++V I+ + Q I Sbjct: 11 VVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHK 70 Query: 52 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 L GH V +A + S S+D+ + +W GT K GH S V SV + Sbjct: 71 ALTGHNHFVSDLALSQENC--FAISSSWDKTLRLWDLRTGTTYK--RFVGHQSEVYSVAF 126 Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 +P + ++ ++ I L GE ++ H+ + V ++P + + Sbjct: 127 SPDNRQIL--SAGAEREIKLWNILGECKFS-SAEKENHSDWVSCVRYSPIMKSAN----- 178 Query: 172 SGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 + + FAS G D +K+W ++ +AH V ++ +P+ I Sbjct: 179 --KVQPFAPYFASVGWDGRLKVWNTN----FQIRYTFKAHESNVNHLSISPN----GKYI 228 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 A+ +D ++ IW N+ P+ + ++++ +AV G D V ++ Sbjct: 229 ATGGKDKKLLIWDI----LNLTYPQREFDAGSTINQIAFNPKLQWVAV-GTDQGVKIF 281 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 45/305 (14%), Positives = 98/305 (32%), Gaps = 50/305 (16%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 + + T H + D + + S D++++++D+R G GH+ V+ Sbjct: 65 FGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTT--YKRFVGHQSEVY 122 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP-------- 113 VA++ + S +R++ +W + E H V+ V ++P Sbjct: 123 SVAFSPD--NRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKV 180 Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 + A DG + + ++++ AH N +S +P Sbjct: 181 QPFAPYFASVGWDGRLKVWNTN----FQIRYTFKAHESNVNHLSISP------------- 223 Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 K A+GG D + +W + + + + + +A+ P + + Sbjct: 224 ----NGKYIATGGKDKKLLIWDIL-NLTYPQREFDAG--STINQIAFNPKL-----QWVA 271 Query: 234 CSQDGRVFIWTCDDASGNMWSP---------KLLHKFNDVVWHVSWSITANILAVSGGDN 284 D V I+ S + N ++W+ L D Sbjct: 272 VGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDG 331 Query: 285 KVTLW 289 + + Sbjct: 332 VIRTF 336 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 23/90 (25%), Positives = 34/90 (37%), Gaps = 5/90 (5%) Query: 208 LEAHSDWVRDVA--WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMW---SPKLLHKFN 262 LE HSDWV + ++ + + S S+D V IW + N + K L N Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKES 292 V ++ S S D + LW Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLR 106 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 47/136 (34%), Gaps = 18/136 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +HE ++ + G +AT D+ + I+D+ N G + Q+A+ + Sbjct: 211 AHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAG--STINQIAFNPKLQ 268 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHS-----------GHDSSVNSVCWAPHDYGLI 119 + D+ V I+ + G + S+ W + G Sbjct: 269 ---WVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAW--NALGKK 323 Query: 120 LACGSSDGAISLLTYT 135 L G +DG I ++ Sbjct: 324 LFAGFTDGVIRTFSFE 339 >6G51-g nrPDB Length = 317 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 91/252 (36%), Gaps = 34/252 (13%) Query: 44 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKE---ENGTWEKTHEHS 100 L L+GH G V Q+A P + +++ S S D+ +I+WK E Sbjct: 2 TEQMTLRGTLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 101 GHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP 160 GH V+ V + G GS DG + L T G + Sbjct: 61 GHSHFVSDVVISSD--GQFALSGSWDGTLRLWDL---------------TTGTTTRRF-- 101 Query: 161 AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAW 220 G D S + ++ SG D IKLW G K + E+HS+WV V + Sbjct: 102 ---VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRF 156 Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVS 280 +P+ P I SC D V +W N + V+ S ++ A Sbjct: 157 SPNSSNP--IIVSCGWDKLVKVWNL----ANCKLKTNHIGHTGYLNTVTVSPDGSLCASG 210 Query: 281 GGDNKVTLWKES 292 G D + LW + Sbjct: 211 GKDGQAMLWDLN 222 Score = 128 bits (321), Expect = 3e-30, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 99/284 (34%), Gaps = 40/284 (14%) Query: 11 SHEDMIHDAQMDYY-GTRLATCSSDRSVKIFDV---RNGGQILIADLRGHEGPVWQVAWA 66 H + + + S D+++ ++ + I LRGH V V + Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 G S S+D + +W GT T GH V SV ++ + + GS D Sbjct: 73 SD--GQFALSGSWDGTLRLWDLTTGT--TTRRFVGHTKDVLSVAFSSDNRQ--IVSGSRD 126 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I L G ++ V+ + +H+ + V ++P S G Sbjct: 127 KTIKLWNTLGVCKYTVQ--DESHSEWVSCVRFSPNSSNPI---------------IVSCG 169 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D L+K+W K + H+ ++ V +P S AS +DG+ +W + Sbjct: 170 WDKLVKVWNL---ANCKLKTNHIGHTGYLNTVTVSPD----GSLCASGGKDGQAMLWDLN 222 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + D++ + +S L + G + +W Sbjct: 223 EGKHLYTLDGG-----DIINALCFSPNRYWLCAATG-PSIKIWD 260 Score = 128 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 95/288 (32%), Gaps = 39/288 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + D + G + S D +++++D+ G GH V VA++ Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT--RRFVGHTKDVLSVAFSSD-- 116 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S S D+ + +W G + T + H V+ V ++P+ I+ D + Sbjct: 117 NRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + ++K + HT N V+ +P ASGG D Sbjct: 176 VWNLAN---CKLKTNHIGHTGYLNTVTVSP-----------------DGSLCASGGKDGQ 215 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD---- 246 LW E L+ D + + ++P+ + + IW + Sbjct: 216 AMLWDLNEGKHL---YTLDG-GDIINALCFSPN-----RYWLCAATGPSIKIWDLEGKII 266 Query: 247 -DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 D ++WS L DN V +W+ ++ Sbjct: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 46/138 (33%), Gaps = 15/138 (10%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 + T H ++ + G+ A+ D ++D+ G + L G + + Sbjct: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH--LYTLDG-GDIINALC 240 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSS-------VNSVCWAPHDYG 117 ++ Y L + + + IW E + +S S+ W+ G Sbjct: 241 FSPNRY--WLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD--G 295 Query: 118 LILACGSSDGAISLLTYT 135 L G +D + + T Sbjct: 296 QTLFAGYTDNLVRVWQVT 313 >6BX3-A nrPDB Length = 314 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 102/291 (35%), Gaps = 25/291 (8%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 +V T+ TSH + G +AT S D SV+I + G L+ GH PV Sbjct: 44 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVIS 100 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + + GN+L + S D + IW NG+ KT S H +V SV P + IL+ Sbjct: 101 LTFNR--KGNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVD-VPMNDSSILSS 155 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 GS DG I + + + ++ + + Sbjct: 156 GSYDGLIRIFDAETGHCLKTLTYDKDWKRE------------NGVVPISQVKFSENARYL 203 Query: 183 ASGGCDNLIKLWREEEDG---QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 D ++K+W ++ + + + + T + S ++G Sbjct: 204 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGD 263 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 ++ W D S L+ + V +S NI+ + LW+ Sbjct: 264 IYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLWR 312 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 17/127 (13%), Positives = 41/127 (32%), Gaps = 22/127 (17%) Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 A+ D +++ + H+ V + + + + + S D + Sbjct: 69 IATASDDFSVEIIHL----SYGLLHTFIGHTAPVISLTFN----RKGNLLFTSSMDESIK 120 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGGDNKVTLWKE--------- 291 IW + S K + ++ V V + ++IL+ D + ++ Sbjct: 121 IWDTLNGS----LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTL 176 Query: 292 SVDGQWV 298 + D W Sbjct: 177 TYDKDWK 183 Score = 27.5 bits (59), Expect = 8.0, Method: Composition-based stats. Identities = 8/40 (20%), Positives = 13/40 (32%) Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 S L+ + WS +A + D V + S Sbjct: 46 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 85 >4V6W-Ag nrPDB Length = 318 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 93/253 (36%), Gaps = 35/253 (13%) Query: 44 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW----KEENGTWEKTHEH 99 + L L GH G V Q+A +P + + S S D+ +I+W E+ Sbjct: 2 SETLQLRGTLIGHNGWVTQIA-TNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 100 SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWA 159 GH ++ V + G GS D + L + + HT +V+++ Sbjct: 61 YGHSHFISDVVLSSD--GNYALSGSWDQTLRLWDLAAG---KTTRRFEGHTKDVLSVAFS 115 Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 ++ SG D IKLW + ++ ++ H+DWV V Sbjct: 116 -----------------ADNRQIVSGSRDKTIKLWNTLAECKFTIQED--GHTDWVSCVR 156 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 ++P+ P I SC D V +W N H N + V+ S ++ Sbjct: 157 FSPNHSNP--IIVSCGWDRTVKVWNL----ANCKLKNNHHGHNGYLNTVTVSPDGSLCTS 210 Query: 280 SGGDNKVTLWKES 292 G D+K LW + Sbjct: 211 GGKDSKALLWDLN 223 Score = 134 bits (338), Expect = 3e-32, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 100/290 (34%), Gaps = 41/290 (14%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H I D + G + S D++++++D+ G GH V VA++ Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTT--RRFEGHTKDVLSVAFSAD-- 117 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S S D+ + +W + T + GH V+ V ++P+ I+ D + Sbjct: 118 NRQIVSGSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVK 176 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + ++K ++ H N V+ +P SGG D+ Sbjct: 177 VWNLAN---CKLKNNHHGHNGYLNTVTVSP-----------------DGSLCTSGGKDSK 216 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT------ 244 LW + + H+D + + ++P+ + + IW Sbjct: 217 ALLWDLNDGKNLYTLE----HNDIINALCFSPN-----RYWLCVAYGPSIKIWDLACKKT 267 Query: 245 CDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 ++ + SP ++WS L DN + +W+ SV Sbjct: 268 VEELRPEVVSPTS-KADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVS 316 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 79/220 (35%), Gaps = 34/220 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + ++ + S D+++K+++ GH V V ++ Sbjct: 104 GHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHS 162 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 I+ SC +DR V +W N + + H GH+ +N+V +P G + G D Sbjct: 163 NPIIVSCGWDRTVKVWNLAN--CKLKNNHHGHNGYLNTVTVSPD--GSLCTSGGKDSKAL 218 Query: 131 LLTYT-GEGQWEVKKINNAHTIGCN------AVSWAPA-------------------VVP 164 L G+ + ++ + + + + V++ P+ V P Sbjct: 219 LWDLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSP 278 Query: 165 GSLIDQP---SGQKPNYIKKFASGGCDNLIKLWREEEDGQ 201 S DQP S + +G DN I++W+ Sbjct: 279 TSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSAH 318 >2HES-X nrPDB Length = 330 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 55/208 (26%), Positives = 94/208 (45%), Gaps = 27/208 (12%) Query: 111 WAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN-NAHTIGCNAVSWAPAVVPGSLID 169 W+ ILA GS+D I L++ + + ++ AH +V+W P Sbjct: 18 WSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRP--------- 68 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKL----EAHSDWVRDVAWAPSIG 225 + A+G D+ + +W +EE E L E H + V+ VAW+ Sbjct: 69 --------HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND-- 118 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNK 285 +A+CS+D V+IW D++ +L + + V HV W + +LA S D+ Sbjct: 119 --GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDT 176 Query: 286 VTLWKESVDGQWVCISDVNKGQGSVSAS 313 V +WK+ D W C++ +N +G+V +S Sbjct: 177 VRIWKD-YDDDWECVAVLNGHEGTVWSS 203 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 115/292 (39%), Gaps = 39/292 (13%) Query: 20 QMDYYGTRLATCSSDRSVKIFDVRNGGQILIADL--RGHEGPVWQVAWAHPMYGNILASC 77 D+ LAT S+DR +K+ V+ LI L H+ + VAW + ++LA+ Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRP--HTSLLAAG 76 Query: 78 SYDRKVIIW-----KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 S+D V IW + + GH++ V V W+ + G LA S D ++ + Sbjct: 77 SFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS--NDGYYLATCSRDKSVWIW 134 Query: 133 TYTGEG-QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 G ++E + H+ V W P+ AS D+ + Sbjct: 135 ETDESGEEYECISVLQEHSQDVKHVIWHPSEA-----------------LLASSSYDDTV 177 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----TCD 246 ++W++ +D W+ L H V + + S S D V +W D Sbjct: 178 RIWKDYDD-DWECVAVLNGHEGTVWSSDF--DKTEGVFRLCSGSDDSTVRVWKYMGDDED 234 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 D + L V++V+W ++A G D + +++E VDG+W Sbjct: 235 DQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEE-VDGEWK 284 Score = 129 bits (324), Expect = 1e-30, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 120/304 (39%), Gaps = 41/304 (13%) Query: 2 VSVINTVD-TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV-----RNGGQILIADLRG 55 ++I+ +D T+H+ I + + LA S D +V I+ R L+A + G Sbjct: 46 FTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEG 105 Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIW--KEENGTWEKTHEHSGHDSSVNSVCWAP 113 HE V VAW++ G LA+CS D+ V IW E +E H V V W P Sbjct: 106 HENEVKGVAWSND--GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP 163 Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 + +LA S D + + + WE + N H + + Sbjct: 164 SEA--LLASSSYDDTVRIW-KDYDDDWECVAVLNGHEGTVWSSDFD-------------- 206 Query: 174 QKPNYIKKFASGGCDNLIKLW-----REEEDGQWKEEQKLEA-HSDWVRDVAWAPSIGLP 227 K + + SG D+ +++W E++ +W E L H V +VAW + Sbjct: 207 -KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG--- 262 Query: 228 TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSW-SITAN-ILAVSGGDNK 285 IAS DG + ++ D +++ + L + V W + ILA G D Sbjct: 263 --LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGI 320 Query: 286 VTLW 289 V W Sbjct: 321 VNFW 324 Score = 128 bits (320), Expect = 4e-30, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 19/245 (7%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIF--DVRNGGQILIADLRGHEGPVWQVAW 65 + HE+ + G LATCS D+SV I+ D I+ L+ H V V W Sbjct: 102 IIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIW 161 Query: 66 AHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 +LAS SYD V IWK+ + WE +GH+ +V S + + L GS Sbjct: 162 HPSEA--LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSD 219 Query: 126 DGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 D + + Y G+ + A++P Q + AS Sbjct: 220 DSTVRVWKYMGDDE------------DDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASV 267 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDW-VRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 G D ++ ++ E + ++ H + + V W G + +A+ DG V W+ Sbjct: 268 GADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNG--KTILATGGDDGIVNFWS 325 Query: 245 CDDAS 249 + A+ Sbjct: 326 LEKAA 330 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 107/269 (39%), Gaps = 43/269 (15%) Query: 49 LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKE--ENGTWEKTHEHSGHDSSV 106 LI L+ ++ +W ++ ILA+ S DRK+ + ++ T + + H ++ Sbjct: 6 LIKSLKLYKEKIWSFDFSQ----GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAI 61 Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEG----QWEVKKINNAHTIGCNAVSWAPAV 162 SV W PH +LA GS D +S+ + ++ I H V+W+ Sbjct: 62 RSVAWRPHTS--LLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS--- 116 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDG-QWKEEQKLEAHSDWVRDVAWA 221 N A+ D + +W +E G +++ L+ HS V+ V W Sbjct: 117 --------------NDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWH 162 Query: 222 PSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI--LAV 279 PS L +AS S D V IW D + +L+ VW + T + L Sbjct: 163 PSEAL----LASSSYDDTVRIW--KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCS 216 Query: 280 SGGDNKVTLWKESVDG-----QWVCISDV 303 D+ V +WK D +WVC + + Sbjct: 217 GSDDSTVRVWKYMGDDEDDQQEWVCEAIL 245 >3JAP-g nrPDB Length = 326 Score = 137 bits (345), Expect = 5e-33, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 105/286 (36%), Gaps = 31/286 (10%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQ---ILIADLRGH 56 ++ V+ H + L + S D+++ + + Q + + +GH Sbjct: 6 IMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGH 65 Query: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 V V + GN S S+D+ + +W G E GH V SV + Sbjct: 66 SHIVQDVVVSAD--GNYAVSASWDKTLRLWNLATGNSE--ARFVGHTGDVLSVAIDANSS 121 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +I S D I + G+ + + HT V AP + +D Sbjct: 122 KII--SASRDKTIRVWNTVGDCAYVLL----GHTDWVTKVRVAPKNLEDGEVD------- 168 Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 + F S G D +++ W ED ++ E H++++ V +P L AS + Sbjct: 169 DGRITFVSAGMDKIVRSWSLNEDS-YRIEADFIGHNNYINVVQPSPDGSLA----ASAGK 223 Query: 237 DGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 DG++++W S M D V+ +++S + L + Sbjct: 224 DGQIYVWNLKHKSAFMNF-----DAKDEVFALAFSPSRFWLTAATA 264 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 81/260 (31%), Gaps = 38/260 (14%) Query: 48 ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKE---ENGTWEKTHEHSGHDS 104 +L L GH G V ++ N+L S S D+ +I W+ E + GH Sbjct: 9 VLRGTLEGHNGWVTSLS-TSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 V V + G S D + L + A Sbjct: 68 IVQDVVVSAD--GNYAVSASWDKTLRLWNLATGN--------------------SEARFV 105 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 G D S K S D I++W D + L H+DWV V AP Sbjct: 106 GHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYV----LLGHTDWVTKVRVAPKN 161 Query: 225 GLPTS------TIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILA 278 T S D V W+ ++ S N+ + V S ++ A Sbjct: 162 LEDGEVDDGRITFVSAGMDKIVRSWSLNEDS--YRIEADFIGHNNYINVVQPSPDGSLAA 219 Query: 279 VSGGDNKVTLWKESVDGQWV 298 +G D ++ +W ++ Sbjct: 220 SAGKDGQIYVWNLKHKSAFM 239 Score = 107 bits (267), Expect = 6e-24, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 96/293 (32%), Gaps = 48/293 (16%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ D + G + S D++++++++ G A GH G V VA Sbjct: 64 GHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSE--ARFVGHTGDVLSVAI--DAN 119 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP--------HDYGLILAC 122 + + S S D+ + +W + GH V V AP D + Sbjct: 120 SSKIISASRDKTIRVWNTVGD---CAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVS 176 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 D + + E + ++ H N V +P Sbjct: 177 AGMDKIVRSWSL-NEDSYRIEADFIGHNNYINVVQPSP-----------------DGSLA 218 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 AS G D I +W + + D V +A++PS T+ AS + I Sbjct: 219 ASAGKDGQIYVWNLKHKSAFMNFDA----KDEVFALAFSPSRFWLTAATASG-----IKI 269 Query: 243 WTCD-----DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + + D ++ + V ++WS L DN + +W+ Sbjct: 270 YDLENEVLIDELKPEFAGYTKAQDPHAV-SLAWSADGQTLFAGYTDNVIRVWQ 321 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 31/93 (33%), Gaps = 4/93 (4%) Query: 198 EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-K 256 + LE H+ WV + + + + S S+D + W + P + Sbjct: 4 SNIMLVLRGTLEGHNGWVTSL---STSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVR 60 Query: 257 LLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + +V V S N + D + LW Sbjct: 61 SYKGHSHIVQDVVVSADGNYAVSASWDKTLRLW 93 Score = 46.0 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 52/132 (39%), Gaps = 10/132 (7%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + I+ Q G+ A+ D + ++++++ + D + V+ +A++ + Sbjct: 201 GHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAK---DEVFALAFSPSRF 257 Query: 71 GNILASCSYDRKVIIWKEENGTW--EKTHEHSGHDSS--VNSVCWAPHDYGLILACGSSD 126 A+ S + I+ EN E E +G+ + ++V A G L G +D Sbjct: 258 WLTAATASG---IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTD 314 Query: 127 GAISLLTYTGEG 138 I + Sbjct: 315 NVIRVWQVMTAN 326 >5WJC-A nrPDB Length = 430 Score = 134 bits (338), Expect = 3e-32, Method: Composition-based stats. Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 32/197 (16%) Query: 12 HEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGPVWQVAWAHPM 69 H D+++D Q + LA+ S D +++I D R N + ++ H + VA +P Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAI-NPF 292 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +LA+ S D+ V +W N ++ H GH+ V + W+PHD ILA S+D + Sbjct: 293 NDYLLATASADKTVALWDLRNPY-QRLHTLEGHEDEVYGLEWSPHDE-PILASSSTDRRV 350 Query: 130 SLLTYT-----------GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 + +G E+ ++ HT + SW P Sbjct: 351 CIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNE---------------- 394 Query: 179 IKKFASGGCDNLIKLWR 195 S DN++++W Sbjct: 395 RWVVGSLADDNILQIWS 411 Score = 120 bits (300), Expect = 9e-28, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 108/308 (35%), Gaps = 49/308 (15%) Query: 12 HEDMIHDAQMDYYG-TRLATCSSDRSVKIFD------VRNGGQILIADLRGHEGPVWQVA 64 H+ ++ A+ +AT + IFD + G + A L+GH + + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWE--------KTHEHSGHDSSVNSVCWAPHDY 116 W + GN LA+ + D+ + +W + ++ ++ H VN V + P Sbjct: 190 WNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHE 248 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +LA S D + + + E K+ AH+ NAV+ P Sbjct: 249 A-LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINP---------------- 291 Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 A+ D + LW ++ LE H D V + W+P +AS S Sbjct: 292 FNDYLLATASADKTVALWDLRN--PYQRLHTLEGHEDEVYGLEWSPH---DEPILASSST 346 Query: 237 DGRVFIWTC----------DDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSGGDNK 285 D RV IW D G+ + + + SW ++ DN Sbjct: 347 DRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNI 406 Query: 286 VTLWKESV 293 + +W S Sbjct: 407 LQIWSPSR 414 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 85/255 (33%), Gaps = 38/255 (14%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWK------EENGTWEKTHEHSGHDSSVNSV 109 H+G V + + P I+A+ I+ G GH + + Sbjct: 130 HDGDVNRARYM-PQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGL 188 Query: 110 CWAPHDYGLILACGSSDGAISLLTY-------TGEGQWEVKKINNAHTIGCNAVSWAPAV 162 CW P+ G LA G+ D I L + + HT N V + P Sbjct: 189 CWNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQ- 246 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 + AS D +++ + + + + ++AHS + VA P Sbjct: 247 ---------------HEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINP 291 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSG 281 +A+ S D V +W + L D V+ + WS ILA S Sbjct: 292 ---FNDYLLATASADKTVALWDLRN---PYQRLHTLEGHEDEVYGLEWSPHDEPILASSS 345 Query: 282 GDNKVTLWKESVDGQ 296 D +V +W G+ Sbjct: 346 TDRRVCIWDLEKIGE 360 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 18/121 (14%), Positives = 46/121 (38%), Gaps = 10/121 (8%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 G+ + L+ H+ + W P++ +A+ ++D + +W S K++ Sbjct: 169 TGEALPQAVLKGHTAEGFGLCWNPNLPGN---LATGAEDQVICLWDVQTQSFTSSETKVI 225 Query: 259 ------HKFNDVVWHVSWSIT-ANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 H+ D+V V + +LA D + + ++ + + +++ Sbjct: 226 SPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAIN 285 Query: 312 A 312 A Sbjct: 286 A 286 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 37/90 (41%), Gaps = 14/90 (15%) Query: 11 SHEDMIHDAQMDYYGT-RLATCSSDRSVKIFDV------------RNGGQILIADLRGHE 57 HED ++ + + LA+ S+DR V I+D+ +G L+ GH Sbjct: 323 GHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHT 382 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 + + +W ++ S + D + IW Sbjct: 383 NRISEFSWCPNERW-VVGSLADDNILQIWS 411 >5FA5-B nrPDB Length = 367 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 51/239 (21%), Positives = 92/239 (38%), Gaps = 30/239 (12%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 + V H+D++ + GT+ + S D +K++D+ Q++++ R H V Sbjct: 139 LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ--QVVLSSYRAHAAQVT 196 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 VA A P ++ SCS D ++++W S S+ W P + Sbjct: 197 CVA-ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQS-EVFV 254 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 G +G +SL+ +++ G + ++P VP Sbjct: 255 FGDENGTVSLVDTKSTSCVLSSAVHSQCVTG---LVFSPHSVP----------------F 295 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 AS D + + D E + +AH D+VRD W+P L S + + D +V Sbjct: 296 LASLSEDCSLAV----LDSSLSELFRSQAHRDFVRDATWSP---LNHSLLTTVGWDHQV 347 Score = 50.6 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 39/259 (15%), Positives = 71/259 (27%), Gaps = 45/259 (17%) Query: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG--HDSSVNSVCWAPH 114 E V + W + + S V +W+ + + HD V++V + Sbjct: 105 EAGVADLTW---VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV--SVL 159 Query: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA-----------------VS 157 G GS D I + + + + A A + Sbjct: 160 SSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 219 Query: 158 W---APAVVPGSLIDQPSGQKPNYIKK------FASGGCDNLIKLWREEEDGQWKEEQKL 208 W P P + F G + + L + Sbjct: 220 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAV- 278 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 HS V + ++P +AS S+D + + + D V Sbjct: 279 --HSQCVTGLVFSPH---SVPFLASLSEDCSLAVLDSSLSELF-----RSQAHRDFVRDA 328 Query: 269 SWSI-TANILAVSGGDNKV 286 +WS ++L G D++V Sbjct: 329 TWSPLNHSLLTTVGWDHQV 347 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 23/60 (38%) Query: 231 IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 I S G V +W D+ + S ++ +D+V VS + D + +W Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 >6QX9-4B nrPDB Length = 522 Score = 131 bits (328), Expect = 5e-31, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 96/310 (30%), Gaps = 50/310 (16%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 + I LAT K++ V L+ LRGH V + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPKST 286 Query: 71 GNI------LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 ++ LASC+ D V +W ++ E + GH V V W P G L Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHP--SGRFLGTTC 342 Query: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW-------------------------A 159 D + L + + ++ H++G +++ Sbjct: 343 YDRSWRLWDLEAQEEILHQE---GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRC 399 Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 + G L + A+G DN K+W + + + AH + V V Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQR---RCVYTIPAHQNLVTGVK 456 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 + P + + + + D IWT K L V + S ++A Sbjct: 457 FEPIH---GNFLLTGAYDNTAKIWT----HPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509 Query: 280 SGGDNKVTLW 289 D LW Sbjct: 510 CSYDRTFKLW 519 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 86/264 (32%), Gaps = 44/264 (16%) Query: 55 GHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH 114 G + P+ ++ +LA+ + +W H GH+++V ++ + P Sbjct: 229 GDDRPISYCHFSP--NSKMLATACWSGLCKLWSV--PDCNLLHTLRGHNTNVGAIVFHPK 284 Query: 115 D------YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 + LA ++DG++ L + + E HT+ V W P+ Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSD---EPVADIEGHTVRVARVMWHPS------- 334 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 + + D +LW E E E HS V D+A+ L Sbjct: 335 ----------GRFLGTTCYDRSWRLWDLEAQE---EILHQEGHSMGVYDIAFHQDGSLAG 381 Query: 229 STIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288 + D +W L ++ +++S +A GDN + Sbjct: 382 ----TGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKV 433 Query: 289 WKESVDGQWVCISDVNKGQGSVSA 312 W Q C+ + Q V+ Sbjct: 434 WDLR---QRRCVYTIPAHQNLVTG 454 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 16/31 (51%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIF 40 HE + + G +ATCS DR+ K++ Sbjct: 489 AGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >5GAN-H nrPDB Length = 465 Score = 131 bits (328), Expect = 5e-31, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 97/234 (41%), Gaps = 31/234 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 HE I D + G + + S D + +++D ++L+ GH+ V+ +++ Sbjct: 263 GHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQ--EGHDKGVFSLSFQCD-- 318 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G+++ S D ++W +G+ K +GH + +V W+P+ G +A G DG I+ Sbjct: 319 GSLVCSGGMDSLSMLWDIRSGS--KVMTLAGHSKPIYTVAWSPN--GYQVATGGGDGIIN 374 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + ++ +I AH V ++ K + KK S G DNL Sbjct: 375 VWDIRKRDEGQLNQIL-AHRNIVTQVRFS---------------KEDGGKKLVSCGYDNL 418 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 I ++ W + L H+D + + + + + S D + +W Sbjct: 419 INVYS---SDTWLKMGSLAGHTDKIISLDISNNS----HFLVSGGWDRSIKLWN 465 Score = 118 bits (294), Expect = 4e-27, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 102/282 (36%), Gaps = 36/282 (12%) Query: 11 SHEDMIHDAQMDYY-GTRLATCSSDRSVKIFDVRN--GGQILIADLRGHEGPVWQVAWAH 67 SH I ++ +C+ D +K F N GG L+ DL GHE + V + H Sbjct: 216 SHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKY-H 274 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P G + S S+D +W E GHD V S+ + G ++ G D Sbjct: 275 PS-GKFIGSASHDMTWRLWDASTHQELLLQE--GHDKGVFSLSF--QCDGSLVCSGGMDS 329 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 L + H+ V+W+P + A+GG Sbjct: 330 LSMLWDIRSGSKVMTL---AGHSKPIYTVAWSPNGY-----------------QVATGGG 369 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D +I +W + + + Q L AH + V V ++ G + SC D + +++ D Sbjct: 370 DGIINVWDIRKRDEGQLNQIL-AHRNIVTQVRFSKEDG--GKKLVSCGYDNLINVYSSDT 426 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 L D + + S ++ L G D + LW Sbjct: 427 ----WLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 98.4 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 4/124 (3%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H I+ G ++AT D + ++D+R + + + H V QV ++ Sbjct: 346 AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKED 405 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 G L SC YD + ++ + TW K +GH + S+ + + + L G D +I Sbjct: 406 GGKKLVSCGYDNLINVYS--SDTWLKMGSLAGHTDKIISLDISNNSH--FLVSGGWDRSI 461 Query: 130 SLLT 133 L Sbjct: 462 KLWN 465 Score = 88.0 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 78/241 (32%), Gaps = 33/241 (13%) Query: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 P+ V+ + ++A+ S+ + + + T + H + ++ W P Sbjct: 175 TKPISAVSLSTDDM--VVATGSWAGDLQVLNSQTLQP-LTQKLDSHVGKIGAIDWHPDSN 231 Query: 117 GLILACGSSDGAISLLTY-TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQK 175 +++C DG I Y EG + H + V + P+ Sbjct: 232 NQMISCA-EDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS-------------- 276 Query: 176 PNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS 235 K S D +LW + + E H V +++ S + S Sbjct: 277 ---GKFIGSASHDMTWRLWDASTHQELLLQ---EGHDKGVFSLSFQCD----GSLVCSGG 326 Query: 236 QDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG 295 D +W S M L + ++ V+WS +A GGD + +W Sbjct: 327 MDSLSMLWDIRSGSKVM----TLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRD 382 Query: 296 Q 296 + Sbjct: 383 E 383 Score = 58.7 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 41/107 (38%), Gaps = 3/107 (2%) Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDV 264 QKL++H + + W P + SC++DG + + + G + L Sbjct: 211 TQKLDSHVGKIGAIDWHPDSNNQ---MISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERR 267 Query: 265 VWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 + V + + + + D LW S + + +KG S+S Sbjct: 268 ISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLS 314 >6EOJ-D nrPDB Length = 470 Score = 130 bits (327), Expect = 7e-31, Method: Composition-based stats. Identities = 51/277 (18%), Positives = 90/277 (32%), Gaps = 31/277 (11%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 S++ +D +H + I D ++ TCS D +KI++ NG Q + L GH V Sbjct: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVK 223 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 W HP G ++AS S D V +W +G + H V + P G +L Sbjct: 224 SCDW-HPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPT-KGNLLM 278 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 S D + + + + + W P Sbjct: 279 AISKDKSCRVFDIRYSMKELMCV---RDETDYMTLEWHPI----------------NESM 319 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 F D +K + ++ AH + +++ P A+ ++D + Sbjct: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP----VGHIFATAAKDRTIR 375 Query: 242 IWT-CDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 WT N + + W + N + Sbjct: 376 FWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAV 412 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 44/284 (15%), Positives = 95/284 (33%), Gaps = 34/284 (11%) Query: 6 NTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW 65 T+ +H+ + + + + + +D +KI+ N + D H + +A+ Sbjct: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-NFSMVKEID-AAHTESIRDMAF 185 Query: 66 AHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 + + +CS D + IW NG E+ SGH V S W P ++A S Sbjct: 186 SS--NDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDWHPEMG--LIASASK 239 Query: 126 DGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 D + L + HT+ + +P + Sbjct: 240 DNLVKLWDPRSGNCIS-SILKFKHTV------------------LKTRFQPTKGNLLMAI 280 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 D +++ + + E +D++ + W P + DG + + Sbjct: 281 SKDKSCRVFDIRYSMKELMCVRDE--TDYMT-LEWHPINESMFTL---ACYDGSLKHFDL 334 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + N + + + + +S++ +I A + D + W Sbjct: 335 -LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 77.6 bits (189), Expect = 6e-15, Method: Composition-based stats. Identities = 40/208 (19%), Positives = 76/208 (36%), Gaps = 36/208 (17%) Query: 103 DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 + ++ W P L++A S G SL + + + AH + ++ Sbjct: 93 KHVIPAIQWTPEGRRLVVATYS--GEFSLWNA---SSFTFETLMQAHDSAVTTMKYS--- 144 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 + SG D +IK+W+ ++ AH++ +RD+A++ Sbjct: 145 --------------HDSDWMISGDADGMIKIWQPNFS---MVKEIDAAHTESIRDMAFSS 187 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 + +CS D + IW + ++L + V W ++A + Sbjct: 188 NDSK----FVTCSDDNILKIWNFSNGK----QERVLSGHHWDVKSCDWHPEMGLIASASK 239 Query: 283 DNKVTLWKESVDGQWVCISDVNKGQGSV 310 DN V LW CIS + K + +V Sbjct: 240 DNLVKLWDPRSGN---CISSILKFKHTV 264 >4G56-B nrPDB Length = 357 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 50/230 (21%), Positives = 87/230 (37%), Gaps = 30/230 (13%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H+D++ + GT+ + D SVK++D+ + ++ H V VA A P Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQ--KAVLKSYNAHSSEVNCVA-ACPGKD 194 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 I SC D ++++W + D+ SV W P + ACG G +SL Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHP-EKDDTFACGDETGNVSL 253 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 + + +++ + G A S+ + AS D + Sbjct: 254 VNIKNPDSAQTSAVHSQNITGL-AYSYHSSPF------------------LASISEDCTV 294 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 + D + E + +H D+V VAW+P L S + D +V Sbjct: 295 AV----LDADFSEVFRDLSHRDFVTGVAWSP---LDHSKFTTVGWDHKVL 337 Score = 68.7 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 85/272 (31%), Gaps = 33/272 (12%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 + D + S +V+++++ +L+ +E + G Sbjct: 97 VTDVAW-VSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAV 155 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 S D V +W K++ + H S VN V P + L+CG DG I L Sbjct: 156 SGGKDFSVKVWDLSQKAVLKSY--NAHSSEVNCVAACPGKDTIFLSCG-EDGRILLWDTR 212 Query: 136 GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR 195 + TI +V+W P +G K + + Sbjct: 213 KPKPATRIDFCASDTIP-TSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAV---- 267 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 HS + +A++ + +AS S+D V + D + Sbjct: 268 ---------------HSQNITGLAYS---YHSSPFLASISEDCTVAVLDADFSEVFRDLS 309 Query: 256 KLLHKFNDVVWHVSWSI-TANILAVSGGDNKV 286 D V V+WS + G D+KV Sbjct: 310 -----HRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 51.4 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 56/170 (32%), Gaps = 27/170 (15%) Query: 103 DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 ++ V V W + G+++A S GA+ L + V K Sbjct: 94 EAGVTDVAWV-SEKGILVA--SDSGAVELWEILEKESLLVNKFAK--------------- 135 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 + + + SGG D +K+W + K AHS V VA P Sbjct: 136 -YEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKS---YNAHSSEVNCVAACP 191 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI 272 + SC +DGR+ +W D + + + V+W Sbjct: 192 G---KDTIFLSCGEDGRILLW--DTRKPKPATRIDFCASDTIPTSVTWHP 236 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 29/78 (37%), Gaps = 5/78 (6%) Query: 215 VRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITA 274 V DVAW G I S G V +W + + + ++ +D+V +S Sbjct: 97 VTDVAWVSEKG-----ILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDG 151 Query: 275 NILAVSGGDNKVTLWKES 292 G D V +W S Sbjct: 152 TQAVSGGKDFSVKVWDLS 169 >5NZU-C nrPDB Length = 905 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 88/283 (31%), Gaps = 35/283 (12%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T+ D + + + + SV +++ Q L+ + PV + Sbjct: 12 TARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHET--QTLVKTFEVCDLPVRAAKFV--A 67 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N + + + D ++ ++ T E+ H H + + P + S D I Sbjct: 68 RKNWVVTGADDMQIRVFNYN--TLERVHMFEAHSDYIRCIAVHPTQ--PFILTSSDDMLI 123 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 L + + +W ++ HT + P +FAS D Sbjct: 124 KLWDW--DKKWSCSQVFEGHTHYVMQIVINP----------------KDNNQFASASLDR 165 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 IK+W+ LE H V + + P + S + D V IW Sbjct: 166 TIKVWQLGSSS---PNFTLEGHEKGVNCIDYYSGGDKP--YLISGADDRLVKIWD----Y 216 Query: 250 GNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 N + L V S+ I+ D V +W S Sbjct: 217 QNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 40/209 (19%), Positives = 72/209 (34%), Gaps = 27/209 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H D I + + T S D +K++D + GH V Q+ +P Sbjct: 97 AHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW-DKKWSCSQVFEGHTHYVMQIVI-NPKD 154 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 N AS S DR + +W+ G+ GH+ VN + + L G+ D + Sbjct: 155 NNQFASASLDRTIKVWQL--GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVK 212 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + Y + + + H + S+ P + +G D Sbjct: 213 IWDYQNKTCVQTLE---GHAQNVSCASFHPE-----------------LPIIITGSEDGT 252 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 +++W ++ E L + V VA Sbjct: 253 VRIWH---SSTYRLESTLNYGMERVWCVA 278 Score = 121 bits (303), Expect = 4e-28, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 90/274 (32%), Gaps = 35/274 (12%) Query: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74 + A+ + T + D +++F+ + H + +A HP + Sbjct: 59 PVRAAKFVARKNWVVTGADDMQIRVFN--YNTLERVHMFEAHSDYIRCIA-VHPTQP-FI 114 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 + S D + +W + W + GH V + P D A S D I + Sbjct: 115 LTSSDDMLIKLWDWDK-KWSCSQVFEGHTHYVMQIVINPKDN-NQFASASLDRTIKVWQL 172 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 G H G N + + SG D L+K+W Sbjct: 173 ---GSSSPNFTLEGHEKGVNCIDYYSG---------------GDKPYLISGADDRLVKIW 214 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 + Q LE H+ V ++ P + I + S+DG V IW S Sbjct: 215 DYQN---KTCVQTLEGHAQNVSCASFHPELP----IIITGSEDGTVRIW----HSSTYRL 263 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288 L+ + VW V+ +N +A+ + + + Sbjct: 264 ESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 84/266 (31%), Gaps = 40/266 (15%) Query: 51 ADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVC 110 L V V HP +LAS Y+ V +W E T KT E D V + Sbjct: 9 RKLTARSDRVKSVDL-HPTEPWMLASL-YNGSVCVWNHETQTLVKTFEVC--DLPVRAAK 64 Query: 111 WAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQ 170 + + G+ D I + Y E + AH+ ++ P Sbjct: 65 FVA--RKNWVVTGADDMQIRVFNY---NTLERVHMFEAHSDYIRCIAVHPTQPF------ 113 Query: 171 PSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTST 230 + D LIKLW D +W Q E H+ +V + P + Sbjct: 114 -----------ILTSSDDMLIKLWDW--DKKWSCSQVFEGHTHYVMQIVINP---KDNNQ 157 Query: 231 IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI--TANILAVSGGDNKVTL 288 AS S D + +W +S N L V + + L D V + Sbjct: 158 FASASLDRTIKVWQLGSSSPNF----TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKI 213 Query: 289 WKESVDGQWVCISDVNKGQGSVSASI 314 W + C+ + +VS + Sbjct: 214 WD--YQNK-TCVQTLEGHAQNVSCAS 236 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 33/161 (20%), Positives = 59/161 (36%), Gaps = 7/161 (4%) Query: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + ++ + A+ S DR++K++ + + L GHE V + + Sbjct: 140 GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF--TLEGHEKGVNCIDYYSGG 197 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 L S + DR V IW +N T +T E GH +V+ + P I+ GS DG + Sbjct: 198 DKPYLISGADDRLVKIWDYQNKTCVQTLE--GHAQNVSCASFHP--ELPIIITGSEDGTV 253 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQ 170 + + ++ + V G Sbjct: 254 RIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGS 294 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 18/133 (13%), Positives = 42/133 (31%), Gaps = 13/133 (9%) Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 + +W E + E VR + + + + + D ++ ++ + Sbjct: 38 SVCVWNHE---TQTLVKTFEVCDLPVRAAKF----VARKNWVVTGADDMQIRVFNYNT-- 88 Query: 250 GNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS 309 + + +D + ++ T + S D + LW D +W C Sbjct: 89 --LERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD--WDKKWSCSQVFEGHTHY 144 Query: 310 VSASITEGQQNEQ 322 V + + N Q Sbjct: 145 VMQIVINPKDNNQ 157 >6N9G-C nrPDB Length = 353 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 79/239 (33%), Gaps = 31/239 (12%) Query: 6 NTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW 65 H + + ++ T S D + ++DV +G L+ GH V + Sbjct: 146 KKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQ--LLQSFHGHGADVLCLDL 203 Query: 66 AHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 A GN S D+K ++W +G + E H+S VNSV + P G A GS Sbjct: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFE--THESDVNSVRYYP--SGDAFASGSD 259 Query: 126 DGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 D L + + + + + S + +G Sbjct: 260 DATCRLYDLRADREVAIYSKES------------------IIFGASSVDFSLSGRLLFAG 301 Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 D I +W + + L H + V + +P + S S D + +W Sbjct: 302 YNDYTINVWDVLKGSR---VSILFGHENRVSTLRVSPD----GTAFCSGSWDHTLRVWA 353 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 79/278 (28%), Gaps = 37/278 (13%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKI----FDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 + G +A D + FD + H + ++ + Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 + + S D +W E+G ++ GH + V + AP + G G D + Sbjct: 168 --ILTASGDGTCALWDVESGQLLQSFH--GHGADVLCLDLAPSETGNTFVSGGCDKKAMV 223 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 + H N+V + P+ FASG D Sbjct: 224 WDMRSGQCVQA---FETHESDVNSVRYYPS-----------------GDAFASGSDDATC 263 Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN 251 +L+ D + E+ V ++ L + + D + +W S Sbjct: 264 RLYDLRADRE-VAIYSKESIIFGASSVDFS----LSGRLLFAGYNDYTINVWDVLKGSR- 317 Query: 252 MWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 +L + V + S D+ + +W Sbjct: 318 ---VSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 95.3 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 51/249 (20%), Positives = 77/249 (30%), Gaps = 35/249 (14%) Query: 51 ADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVC 110 L+GH V + W + S S D KVI+W + T K H + + V + Sbjct: 57 RTLKGHGNKVLCMDWCKDK--RRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACA 112 Query: 111 WAPHDYGLILACGSSDGAISLLTY---TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSL 167 +AP G +ACG D S+ E KK HT +A S+ Sbjct: 113 YAP--SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--------- 161 Query: 168 IDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP 227 N + + D LW E + H V + APS Sbjct: 162 --------TNSDMQILTASGDGTCALWDVESGQLLQS---FHGHGADVLCLDLAPS--ET 208 Query: 228 TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 287 +T S D + +W + V V + + + A D Sbjct: 209 GNTFVSGGCDKKAMVWDMRSGQ----CVQAFETHESDVNSVRYYPSGDAFASGSDDATCR 264 Query: 288 LWKESVDGQ 296 L+ D + Sbjct: 265 LYDLRADRE 273 Score = 48.3 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 36/94 (38%), Gaps = 8/94 (8%) Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 K + L+ H + V + W I S SQDG+V +W + Sbjct: 54 KTRRTLKGHGNKVLCMDWC----KDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC---- 105 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 V +++ + +A G DNK +++ + D Sbjct: 106 TWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKN 139 Score = 34.8 bits (78), Expect = 0.045, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 15/39 (38%) Query: 252 MWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 M + + L + V + W + S D KV +W Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91 >3JB9-L nrPDB Length = 340 Score = 128 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 54/305 (17%), Positives = 105/305 (34%), Gaps = 42/305 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + A+ D G+ A+ DR + +++V G L G +G + + W+ Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNV-FGDVKNYGVLNGCKGAITDLQWSRD-- 104 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 ++ S D ++ W +G +K +H GH VN++ +L S D + Sbjct: 105 SRVVYCSSSDTHLMSWDAVSG--QKIRKHKGHAGVVNALD-VLKVGSELLTSVSDDCTMK 161 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + + + + + GG D Sbjct: 162 VWDSRSKDCIKTIEEKY---------------------PLTAVAIAQQGTQVFIGGIDGA 200 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 IK+W + L+ H D + +A I S++ S S D V I+ + Sbjct: 201 IKIWDLRNN---HCSHVLKGHKDIITSLA----ISKDGSSLLSNSMDNTVRIFDVKPFAS 253 Query: 251 NMWSPKLL----HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 ++ H + V+WS + + D V +W + D ++ + Sbjct: 254 AQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRY----VLPGH 309 Query: 307 QGSVS 311 +GSV+ Sbjct: 310 EGSVN 314 Score = 96.1 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 38/127 (29%), Positives = 59/127 (46%), Gaps = 13/127 (10%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGG------QILIADLRGHEGPVWQVA 64 H+D+I + G+ L + S D +V+IFDV+ QI + G E + VA Sbjct: 217 GHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVA 276 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 W+ + + S D+ V +W + T + + GH+ SVN V + PH I+ S Sbjct: 277 WSR--NSRFVGAGSSDKNVYVW---SATGDLRYVLPGHEGSVNHVDFHPHQD--IILSCS 329 Query: 125 SDGAISL 131 SD I L Sbjct: 330 SDRTIFL 336 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 28/162 (17%), Positives = 48/162 (29%), Gaps = 15/162 (9%) Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 + G + + FASGG D I LW G K L + D+ Sbjct: 43 NLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVF--GDVKNYGVLNGCKGAITDLQ 100 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSW-SITANILA 278 W+ + + S D + W + VV + + + +L Sbjct: 101 WS----RDSRVVYCSSSDTHLMSWDAVSGQK----IRKHKGHAGVVNALDVLKVGSELLT 152 Query: 279 VSGGDNKVTLWKESVDGQWVCISDVNKGQG-SVSASITEGQQ 319 D + +W CI + + + A +G Q Sbjct: 153 SVSDDCTMKVWDSRSKD---CIKTIEEKYPLTAVAIAQQGTQ 191 Score = 36.4 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 14/28 (50%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSV 37 HE ++ + + +CSSDR++ Sbjct: 307 PGHEGSVNHVDFHPHQDIILSCSSDRTI 334 >6QDV-o nrPDB Length = 513 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 96/284 (33%), Gaps = 35/284 (12%) Query: 10 TSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 + H + ++ G L +CS D +K+++V G + + GH V + + Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRDICFNT- 276 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH-DYGLILACGSSDG 127 G S +YDR + +W E G + V + P D + G SD Sbjct: 277 -AGTQFLSAAYDRYLKLWDTETGQCISRFTN---RKVPYCVKFNPDEDKQNLFVAGMSDK 332 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 I E+ + + H N + + + ++F S Sbjct: 333 KIVQWDIRSG---EIVQEYDRHLGAVNTIVFV-----------------DENRRFVSTSD 372 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D +++W + +K + HS V +P+ +A S D ++ I+ + Sbjct: 373 DKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPN----GKWLACQSMDNQILIFGAQN 426 Query: 248 A-SGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 N H V +S + + G+ K+ +W Sbjct: 427 RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 470 Score = 114 bits (284), Expect = 6e-26, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 98/284 (34%), Gaps = 38/284 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM- 69 H + D + GT+ + + DR +K++D G I+ + P + V + Sbjct: 264 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQ--CISRFTNRKVP-YCVKFNPDED 320 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N+ + D+K++ W +G E E+ H +VN++ + D S D ++ Sbjct: 321 KQNLFVAGMSDKKIVQWDIRSG--EIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSL 376 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + + ++ + H P+ K A DN Sbjct: 377 RVWEWDIPVDFKYIAEPSMH-------------------SMPAVTLSPNGKWLACQSMDN 417 Query: 190 LIKLWREEEDGQWKEEQKLEAH--SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 I ++ + + +++ + H + + V ++P + S + S +G++ IW Sbjct: 418 QILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM----SYVISGDGNGKLNIWDWKT 473 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGGDNKVTLWK 290 + V W + + G D + LW Sbjct: 474 TK----LYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 64/209 (30%), Gaps = 29/209 (13%) Query: 94 EKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 153 ++ H SGH V++V P G +L S D I L GE + + H+ Sbjct: 213 KQIHVWSGHTKGVSAVRLFP-LSGHLLLSCSMDCKIKLWEVYGERR--CLRTFIGHSKAV 269 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 + + A +F S D +KLW E GQ Sbjct: 270 RDICFNTAGT-----------------QFLSAAYDRYLKLWD-TETGQCISRFTNRKVP- 310 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSIT 273 V + P +A S D ++ W + + V + + Sbjct: 311 --YCVKFNPDEDKQNLFVAGMS-DKKIVQWDIRSGE----IVQEYDRHLGAVNTIVFVDE 363 Query: 274 ANILAVSGGDNKVTLWKESVDGQWVCISD 302 + D + +W+ + + I++ Sbjct: 364 NRRFVSTSDDKSLRVWEWDIPVDFKYIAE 392 >5YZG-W nrPDB Length = 579 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 96/284 (33%), Gaps = 35/284 (12%) Query: 10 TSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 + H + ++ G L +CS D +K+++V G + + GH V + + Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRDICFNT- 342 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH-DYGLILACGSSDG 127 G S +YDR + +W E G + V + P D + G SD Sbjct: 343 -AGTQFLSAAYDRYLKLWDTETGQCISRFTN---RKVPYCVKFNPDEDKQNLFVAGMSDK 398 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 I E+ + + H N + + + ++F S Sbjct: 399 KIVQWDIRSG---EIVQEYDRHLGAVNTIVFV-----------------DENRRFVSTSD 438 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D +++W + +K + HS V +P+ +A S D ++ I+ + Sbjct: 439 DKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPN----GKWLACQSMDNQILIFGAQN 492 Query: 248 A-SGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 N H V +S + + G+ K+ +W Sbjct: 493 RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536 Score = 114 bits (284), Expect = 6e-26, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 98/284 (34%), Gaps = 38/284 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM- 69 H + D + GT+ + + DR +K++D G I+ + P + V + Sbjct: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQ--CISRFTNRKVP-YCVKFNPDED 386 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N+ + D+K++ W +G E E+ H +VN++ + D S D ++ Sbjct: 387 KQNLFVAGMSDKKIVQWDIRSG--EIVQEYDRHLGAVNTIVFV--DENRRFVSTSDDKSL 442 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + + ++ + H P+ K A DN Sbjct: 443 RVWEWDIPVDFKYIAEPSMH-------------------SMPAVTLSPNGKWLACQSMDN 483 Query: 190 LIKLWREEEDGQWKEEQKLEAH--SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 I ++ + + +++ + H + + V ++P + S + S +G++ IW Sbjct: 484 QILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM----SYVISGDGNGKLNIWDWKT 539 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGGDNKVTLWK 290 + V W + + G D + LW Sbjct: 540 TK----LYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 66.0 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 64/209 (30%), Gaps = 29/209 (13%) Query: 94 EKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 153 ++ H SGH V++V P G +L S D I L GE + + H+ Sbjct: 279 KQIHVWSGHTKGVSAVRLFP-LSGHLLLSCSMDCKIKLWEVYGERR--CLRTFIGHSKAV 335 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 + + A +F S D +KLW E GQ Sbjct: 336 RDICFNTAGT-----------------QFLSAAYDRYLKLWD-TETGQCISRFTNRKVP- 376 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSIT 273 V + P +A S D ++ W + + V + + Sbjct: 377 --YCVKFNPDEDKQNLFVAGMS-DKKIVQWDIRSGE----IVQEYDRHLGAVNTIVFVDE 429 Query: 274 ANILAVSGGDNKVTLWKESVDGQWVCISD 302 + D + +W+ + + I++ Sbjct: 430 NRRFVSTSDDKSLRVWEWDIPVDFKYIAE 458 >6ID0-T nrPDB Length = 514 Score = 124 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 92/283 (32%), Gaps = 41/283 (14%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 V + H + ++ T S+DR++KI+D+ +G L L GH V V + Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHISTVRGVIVST 256 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 L SC D++V W E + + GH S+V + P +L S D Sbjct: 257 --RSPYLFSCGEDKQVKCWDLEYNKVIRHYH--GHLSAVYGLDLHPTID--VLVTCSRDS 310 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + + + P + +G Sbjct: 311 TARIWDVRTKASVHTLSGHTNAVATVRCQAAEP--------------------QIITGSH 350 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D I+LW K L H VR V P T AS S D + W D Sbjct: 351 DTTIRLWDLVAG---KTRVTLTNHKKSVRAVVLHPRH----YTFASGSPDN-IKQWKFPD 402 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 S + L N ++ ++ + +L + + LW Sbjct: 403 GSF----IQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWD 440 Score = 98.8 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 44/267 (16%), Positives = 77/267 (28%), Gaps = 41/267 (15%) Query: 45 GGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDS 104 L + GH G V +A + S DR + IW +G + +GH S Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLK--LSLTGHIS 247 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 +V V + +CG D + +V + + H + P + Sbjct: 248 TVRGV-IVSTRSPYLFSCG-EDKQVKCWDLEYN---KVIRHYHGHLSAVYGLDLHPTIDV 302 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 + D+ ++W L H++ V V Sbjct: 303 -----------------LVTCSRDSTARIWDV---RTKASVHTLSGHTNAVATVR----C 338 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 I + S D + +W + L V V A DN Sbjct: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRV----TLTNHKKSVRAVVLHPRHYTFASGSPDN 394 Query: 285 KVTLWKESVDGQWVCISDVNKGQGSVS 311 + WK DG + I +++ ++ Sbjct: 395 -IKQWKFP-DGSF--IQNLSGHNAIIN 417 Score = 67.9 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 52/167 (31%), Gaps = 16/167 (9%) Query: 157 SWAP-----AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAH 211 W P V+ G L + F +G D IK+W K + L H Sbjct: 189 QWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSLTGH 245 Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS 271 VR V + + + SC +D +V W + + H V+ + Sbjct: 246 ISTVRGVI----VSTRSPYLFSCGEDKQVKCWDLEYNKV----IRHYHGHLSAVYGLDLH 297 Query: 272 ITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQ 318 T ++L D+ +W +S +V E Q Sbjct: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ 344 Score = 57.2 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 68/190 (35%), Gaps = 43/190 (22%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 + H + + + ++ T S D +++++D+ G + L H+ V V Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRV--TLTNHKKSVRAVVLHPRH 384 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSV-------------------- 109 Y AS S D + WK +G++ + SGH++ +N++ Sbjct: 385 Y--TFASGSPDN-IKQWKFPDGSFIQN--LSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439 Query: 110 CW----------------APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 153 W + I AC LLT + +V + ++ T Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEET 499 Query: 154 NAVSWAPAVV 163 + VSW P ++ Sbjct: 500 HPVSWKPEII 509 >6HHQ-h nrPDB Length = 319 Score = 121 bits (304), Expect = 3e-28, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 93/285 (32%), Gaps = 37/285 (12%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQ---ILIADLRGHE 57 V V+ H + L + S D+++ + + Q + + +GH Sbjct: 6 VLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHS 65 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYG 117 V G S S+D+ + +W G E GH S V SV Sbjct: 66 HIVQDCTLTAD--GAYALSASWDKTLRLWDVATG--ETYQRFVGHKSDVMSVDI--DKKA 119 Query: 118 LILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPN 177 ++ GS D I + T G+ + H + V P + + + Sbjct: 120 SMIISGSRDKTIKVWTIKGQCLATLL----GHNDWVSQVRVVP-----------NEKADD 164 Query: 178 YIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD 237 S G D ++K W Q++ E H+ + + +P + IAS +D Sbjct: 165 DSVTIISAGNDKMVKAWNLN---QFQIEADFIGHNSNINTLTASPD----GTLIASAGKD 217 Query: 238 GRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 G + +W D V+ +++S LA + Sbjct: 218 GEIMLWNLAAKKAMYTLSA-----QDEVFSLAFSPNRYWLAAATA 257 Score = 118 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 75/253 (29%), Gaps = 36/253 (14%) Query: 42 VRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT---WEKTHE 98 N +L L GH G V +A N+L S S D+ +I WK Sbjct: 2 ASNEVLVLRGTLEGHNGWVTSLA-TSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRS 60 Query: 99 HSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW 158 GH V G S D + L ++ Sbjct: 61 FKGHSHIVQDCTLTAD--GAYALSASWDKTLRLWDVATGETYQ----------------- 101 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 G D S SG D IK+W + + L H+DWV V Sbjct: 102 ---RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW----TIKGQCLATLLGHNDWVSQV 154 Query: 219 AWAPSIGL--PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI 276 P+ + TI S D V W + N + ++ S + Sbjct: 155 RVVPNEKADDDSVTIISAGNDKMVKAWNLN----QFQIEADFIGHNSNINTLTASPDGTL 210 Query: 277 LAVSGGDNKVTLW 289 +A +G D ++ LW Sbjct: 211 IASAGKDGEIMLW 223 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 97/288 (33%), Gaps = 44/288 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ D + G + S D++++++DV G GH+ V V Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGET--YQRFVGHKSDVMSVDI--DKK 118 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH----DYGLILACGSSD 126 +++ S S D+ + +W + + GH+ V+ V P+ D + + +D Sbjct: 119 ASMIISGSRDKTIKVWTIKG---QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGND 175 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 + Q++++ H N ++ +P AS G Sbjct: 176 KMVKAWNL---NQFQIEADFIGHNSNINTLTASPDGT-----------------LIASAG 215 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS----CSQDGRVFI 242 D I LW K L A D V +A++P+ + A+ S D + + Sbjct: 216 KDGEIMLWNL---AAKKAMYTLSA-QDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLV 271 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 H ++WS L DN + +W+ Sbjct: 272 DDLRPEFAGYSKAAEPHA-----VSLAWSADGQTLFAGYTDNVIRVWQ 314 Score = 74.5 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 62/230 (26%), Gaps = 37/230 (16%) Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 147 N GH+ V S+ + +L S D + TG+ Sbjct: 2 ASNEVLVLRGTLEGHNGWVTSLATSAGQ-PNLLLSASRDKTLISWKLTGDD--------- 51 Query: 148 AHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQK 207 G S+ G S D ++LW + Q+ Sbjct: 52 -QKFGVPVRSFK-----GHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETY---QR 102 Query: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWH 267 H V V I S I S S+D + +WT L ND V Sbjct: 103 FVGHKSDVMSV----DIDKKASMIISGSRDKTIKVWTIKG-----QCLATLLGHNDWVSQ 153 Query: 268 VSWSITANI------LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 V + +G D V W + Q+ +D +++ Sbjct: 154 VRVVPNEKADDDSVTIISAGNDKMVKAWNLN---QFQIEADFIGHNSNIN 200 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 24/181 (13%), Positives = 50/181 (27%), Gaps = 60/181 (33%) Query: 11 SHEDMIHDAQMDYYGT------RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 H D + ++ + + +D+ VK +++ + AD GH + + Sbjct: 146 GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL--NQFQIEADFIGHNSNINTLT 203 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY-------- 116 + G ++AS D ++++W T V S+ ++P+ Y Sbjct: 204 ASPD--GTLIASAGKDGEIMLWNLAAKKAMYTLSA---QDEVFSLAFSPNRYWLAAATAT 258 Query: 117 ---------------------------------------GLILACGSSDGAISLLTYTGE 137 G L G +D I + Sbjct: 259 GIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTA 318 Query: 138 G 138 Sbjct: 319 N 319 >5K1B-B nrPDB Length = 677 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 95/273 (34%), Gaps = 29/273 (10%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL-IADLRGHEGPVWQVAWAHPMYGNIL 74 ++ Q+D RL T D ++I+ V Q IA + H V + G L Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC--NGKTL 90 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 S S D V +W G T H V ++ +A ++A D I L Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLR--THKDYVKALAYAKD--KELVASAGLDRQIFLWDV 146 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 + +T+ +++S G+ S SG + ++++W Sbjct: 147 N----TLTALTASNNTVTTSSLS-------GNKDSIYSLAMNQLGTIIVSGSTEKVLRVW 195 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 + + KL+ H+D V+ + + + S S DG + +W+ G Sbjct: 196 ---DPRTCAKLMKLKGHTDNVKALL----LNRDGTQCLSGSSDGTIRLWSL----GQQRC 244 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 287 ++ VW + + + G D K+ Sbjct: 245 IATYRVHDEGVWALQVNDAFTHVYSGGRDRKIY 277 Score = 94.9 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 29/147 (19%), Positives = 61/147 (41%), Gaps = 14/147 (9%) Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 Q + + + G D++I++W + Q +E H+DWV D+ + T+ S Sbjct: 37 QLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN----GKTLIS 92 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 S D V +W + L D V ++++ ++A +G D ++ LW + Sbjct: 93 ASSDTTVKVWNAHKG----FCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN- 147 Query: 294 DGQWVCISDVNKGQGSVSASITEGQQN 320 ++ + +V+ S G ++ Sbjct: 148 -----TLTALTASNNTVTTSSLSGNKD 169 Score = 94.1 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 49/243 (20%), Positives = 92/243 (37%), Gaps = 40/243 (16%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H D ++D + G L + SSD +VK+++ G ++ LR H+ V +A+A Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG--FCMSTLRTHKDYVKALAYAKDK-- 129 Query: 72 NILASCSYDRKVIIWKEEN-------GTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGS 124 ++AS DR++ +W T SG+ S+ S+ + G I+ GS Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAM--NQLGTIIVSGS 187 Query: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFAS 184 ++ + + ++ K+ HT A+ + S Sbjct: 188 TEKVLRVWD--PRTCAKLMKL-KGHTDNVKALLLN-----------------RDGTQCLS 227 Query: 185 GGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 G D I+LW GQ + H + V WA + + + S +D +++ Sbjct: 228 GSSDGTIRLWSL---GQQRCIATYRVHDEGV----WALQVNDAFTHVYSGGRDRKIYCTD 280 Query: 245 CDD 247 + Sbjct: 281 LRN 283 Score = 87.6 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 65/246 (26%), Gaps = 40/246 (16%) Query: 72 NILASCSYDRKVIIWKEENGTWEK-THEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 N L + D + IW + H VN + + G L SSD + Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN--GKTLISASSDTTVK 100 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + H A+++A + AS G D Sbjct: 101 VWNAHKGFCMSTLRT---HKDYVKALAYA-----------------KDKELVASAGLDRQ 140 Query: 191 IKLWREEE------DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 I LW L + D + +A + + I S S + + +W Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA----MNQLGTIIVSGSTEKVLRVWD 196 Query: 245 CDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVN 304 L D V + + D + LW GQ CI+ Sbjct: 197 PRT----CAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL---GQQRCIATYR 249 Query: 305 KGQGSV 310 V Sbjct: 250 VHDEGV 255 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 52/136 (38%), Gaps = 8/136 (5%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 +V + + ++D I+ M+ GT + + S+++ ++++D R + L+GH V Sbjct: 158 TVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT--CAKLMKLKGHTDNVKA 215 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + G S S D + +W G + HD V ++ +D + Sbjct: 216 LLLNRD--GTQCLSGSSDGTIRLWSL--GQQRCIATYRVHDEGVWALQ--VNDAFTHVYS 269 Query: 123 GSSDGAISLLTYTGEG 138 G D I Sbjct: 270 GGRDRKIYCTDLRNPD 285 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 62/193 (32%), Gaps = 8/193 (4%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D + ++ GT+ + SSD +++++ + G Q IA R H+ VW + Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL--GQQRCIATYRVHDEGVWALQVNDAF- 264 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH-DYGLILACGSSDGAI 129 + S DRK+ N + V + D + ++ + Sbjct: 265 -THVYSGGRDRKIYCTDLRNPDIRVL--ICEEKAPVLKMELDRSADPPPAIWVATTKSTV 321 Query: 130 SLLTYTGEGQWEVK-KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 + T G + +N T + P V N + + + Sbjct: 322 NKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTN 381 Query: 189 NLIKLWREEEDGQ 201 N + W + + Sbjct: 382 NNVAYWDVLKACK 394 >4XYI-A nrPDB Length = 430 Score = 120 bits (301), Expect = 6e-28, Method: Composition-based stats. Identities = 48/197 (24%), Positives = 83/197 (42%), Gaps = 32/197 (16%) Query: 12 HEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIAD-LRGHEGPVWQVAWAHPM 69 H +++D Q + L + S D +++I D R + ++ HE PV VA+ +P Sbjct: 234 HTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAF-NPF 292 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +LA+ S D V +W ++ H GH+ V +V W+PHD IL S+D + Sbjct: 293 NDYLLATASADHTVALWDLRRLN-QRLHTLEGHEDEVYNVQWSPHDE-PILVTSSTDRRV 350 Query: 130 SLLTY-----------TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 + + +G E+ ++ HT + +SW P N Sbjct: 351 CVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNP----------------NN 394 Query: 179 IKKFASGGCDNLIKLWR 195 AS DN++++W Sbjct: 395 KWVLASLADDNILQIWS 411 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 39/144 (27%), Positives = 66/144 (45%), Gaps = 16/144 (11%) Query: 3 SVINTVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 S + +HE ++ + LAT S+D +V ++D+R Q + L GHE V+ Sbjct: 271 SSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQ-RLHTLEGHEDEVY 329 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKE------------ENGTWEKTHEHSGHDSSVNSV 109 V W+ P IL + S DR+V +W E+G E H GH + V+ + Sbjct: 330 NVQWS-PHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDL 388 Query: 110 CWAPHDYGLILACGSSDGAISLLT 133 W P++ +LA + D + + + Sbjct: 389 SWNPNNK-WVLASLADDNILQIWS 411 Score = 101 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 99/304 (32%), Gaps = 49/304 (16%) Query: 12 HEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILI------ADLRGHEGPVWQVA 64 HE ++ A+ +AT + + IFD+ + I A LR H + + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTW--------EKTHEHSGHDSSVNSVCWAPHDY 116 W G LA+ + D + +W + + + H + VN + + Sbjct: 190 WNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +L S D + + + AH N V++ P Sbjct: 249 A-LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNP---------------- 291 Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 A+ D+ + LW Q LE H D V +V W+P + + S Sbjct: 292 FNDYLLATASADHTVALWDLRRLNQR--LHTLEGHEDEVYNVQWSPH---DEPILVTSST 346 Query: 237 DGRVFIWTC----------DDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSGGDNK 285 D RV +W D G + + V +SW+ +LA DN Sbjct: 347 DRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNI 406 Query: 286 VTLW 289 + +W Sbjct: 407 LQIW 410 Score = 88.4 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 89/265 (33%), Gaps = 38/265 (14%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHE------HSGHDSSVNSV 109 HEG V + + P +I+A+ + I+ + + H S + Sbjct: 130 HEGDVNKARFM-PQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN-------NAHTIGCNAVSWAPAV 162 W G LA G+ D +I + G+ K I+ + HT N + + Sbjct: 189 GWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQ- 246 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 + S D +++ Q ++AH V VA+ P Sbjct: 247 ---------------HEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNP 291 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSG 281 +A+ S D V +W + + L D V++V WS IL S Sbjct: 292 ---FNDYLLATASADHTVALWDLRRLNQRL---HTLEGHEDEVYNVQWSPHDEPILVTSS 345 Query: 282 GDNKVTLWKESVDGQWVCISDVNKG 306 D +V +W S G+ + D G Sbjct: 346 TDRRVCVWDLSKIGEEQTVEDSEDG 370 >4V8M-A7 nrPDB Length = 318 Score = 120 bits (301), Expect = 6e-28, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 88/253 (34%), Gaps = 38/253 (15%) Query: 48 ILIADLRGHEGPVWQVAWAH-PMYGNILASCSYDRKVIIW-------KEENGTWEKTHEH 99 L GH G V +A P + S S D+ ++ W E Sbjct: 4 AYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL 63 Query: 100 SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWA 159 GH + V+ V + + G S D ++ L + + HT +V+++ Sbjct: 64 EGHSAFVSDVALS--NNGNFAVSASWDHSLRLWNLQNG---QCQYKFLGHTKDVLSVAFS 118 Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 P ++ SGG DN +++W + + + AH+DWV V Sbjct: 119 P-----------------DNRQIVSGGRDNALRVWNVKGECMHTLSRG--AHTDWVSCVR 159 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 ++PS+ P I S D V +W L + V V+ S ++ A Sbjct: 160 FSPSLDAP--VIVSGGWDNLVKVWDLATG----RLVTDLKGHTNYVTSVTVSPDGSLCAS 213 Query: 280 SGGDNKVTLWKES 292 S D LW + Sbjct: 214 SDKDGVARLWDLT 226 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 41/282 (14%), Positives = 87/282 (30%), Gaps = 37/282 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + D + G + S D S+++++++NG GH V VA++ Sbjct: 65 GHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQY--KFLGHTKDVLSVAFSPD-- 120 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S D + +W + G T H V+ V ++P ++ G D + Sbjct: 121 NRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVK 179 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + K + + AS D + Sbjct: 180 VWDLATGRLVTDLKGHTNYVTSVT--------------------VSPDGSLCASSDKDGV 219 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +LW + E A + + ++P+ + + + I+ ++ Sbjct: 220 ARLWDLTKGEALSE----MAAGAPINQICFSPN-----RYWMCAATEKGIRIFDLENKDI 270 Query: 251 NMWSP---KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + + K ++WS + L DN + +W Sbjct: 271 IVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 33/121 (27%), Gaps = 43/121 (35%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGG---------------------QIL 49 H + + + G+ A+ D +++D+ G + Sbjct: 194 GHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMC 253 Query: 50 IADLRG------------------HEGPVW----QVAWAHPMYGNILASCSYDRKVIIWK 87 A +G H+G V+ A G+ L S D + +W Sbjct: 254 AATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWG 313 Query: 88 E 88 Sbjct: 314 V 314 >3MKQ-A nrPDB Length = 814 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 86/270 (31%), Gaps = 36/270 (13%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 E + + + S D +++F+ G +++ D H + +A HP Sbjct: 55 ETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVV--DFEAHPDYIRSIA-VHPTKPY 111 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 +L S S D V +W EN W GH+ V V + P D A G D + + Sbjct: 112 VL-SGSDDLTVKLWNWEN-NWALEQTFEGHEHFVMCVAFNPKDPST-FASGCLDRTVKVW 168 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + + G N V + P + D IK Sbjct: 169 SLGQ--STPNFTLTTGQERGVNYVDYYPLP---------------DKPYMITASDDLTIK 211 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 +W + LE H V + P++ I S S+DG + IW Sbjct: 212 IWDYQ---TKSCVATLEGHMSNVSFAVFHPTLP----IIISGSEDGTLKIWNSSTYKVEK 264 Query: 253 WSPKLLHKFNDVVWHVSWSITA--NILAVS 280 L + W ++ T N +A Sbjct: 265 TLNVGLERS----WCIATHPTGRKNYIASG 290 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 80/228 (35%), Gaps = 28/228 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H D I + + + S D +VK+++ N L GHE V VA+ +P Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN-NWALEQTFEGHEHFVMCVAF-NPKD 152 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + AS DR V +W T T +G + VN V + P + S D I Sbjct: 153 PSTFASGCLDRTVKVWSLGQSTPNFTLT-TGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + Y + + H + + P + SG D Sbjct: 212 IWDYQTKSCVATLE---GHMSNVSFAVFHPT-----------------LPIIISGSEDGT 251 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG 238 +K+W +K E+ L + +A P+ + IAS +G Sbjct: 252 LKIWN---SSTYKVEKTLNVGLERSWCIATHPTGR--KNYIASGFDNG 294 Score = 113 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 87/281 (30%), Gaps = 36/281 (12%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 D + + T V+I++ Q+ + ++ E PV + N Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVEIWNYET--QVEVRSIQVTETPVRAGKFI--ARKN 68 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 + S D ++ ++ G EK + H + S+ P + GS D + L Sbjct: 69 WIIVGSDDFRIRVFNYNTG--EKVVDFEAHPDYIRSIAVHP--TKPYVLSGSDDLTVKLW 124 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + E W +++ H V++ P FASG D +K Sbjct: 125 NW--ENNWALEQTFEGHEHFVMCVAFNP----------------KDPSTFASGCLDRTVK 166 Query: 193 LWREEEDGQWKEEQKLE-AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN 251 +W + L V V + P P + + S D + IW S Sbjct: 167 VWSLGQS---TPNFTLTTGQERGVNYVDYYPLPDKP--YMITASDDLTIKIWDYQTKS-- 219 Query: 252 MWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 L V + T I+ D + +W S Sbjct: 220 --CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSS 258 >5OPT-p nrPDB Length = 318 Score = 118 bits (294), Expect = 4e-27, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 92/285 (32%), Gaps = 37/285 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + D + G + S D S+++++++ G + GH V V ++ Sbjct: 65 GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG--VCQHKFLGHTKDVLSVTFSPD-- 120 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S D + +W + G T H V+ V ++P ++ G D + Sbjct: 121 NRQIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVK 179 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + HT +V+ +P AS D + Sbjct: 180 VWDIASG---RLLTDLKGHTNYITSVTVSP-----------------DGSLCASSDKDGV 219 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +LW + E A + + ++P+ + + + I+ ++ Sbjct: 220 ARLWDLTKGEALSE----MAAGAPINQICFSPN-----RYWMCAATEKGIRIFDLENKDV 270 Query: 251 NMWS---PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 + + K ++WS N L DN + +W S Sbjct: 271 IVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 114 bits (286), Expect = 3e-26, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 38/253 (15%) Query: 48 ILIADLRGHEGPVWQVAWAHPMYGNI-LASCSYDRKVIIW----KEENGTWE---KTHEH 99 + L+GH G V +A I S S D +I W + E Sbjct: 4 VYEGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRL 63 Query: 100 SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWA 159 GH + V+ V + + G S D ++ L + HT +V+++ Sbjct: 64 EGHSAFVSDVALSNN--GDFAVSASWDHSLRLWNLQTGVC---QHKFLGHTKDVLSVTFS 118 Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 P ++ SGG DN +++W + G+ AH+DWV V Sbjct: 119 P-----------------DNRQIVSGGRDNALRVWNVK--GECLHTLGRGAHTDWVSCVR 159 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 ++PS+ P I S D V +W L + + V+ S ++ A Sbjct: 160 FSPSLETP--LIVSGGWDNLVKVWDIASG----RLLTDLKGHTNYITSVTVSPDGSLCAS 213 Query: 280 SGGDNKVTLWKES 292 S D LW + Sbjct: 214 SDKDGVARLWDLT 226 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 49/171 (28%), Gaps = 49/171 (28%) Query: 11 SHEDMIHDAQMDYY--GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 +H D + + + + D VK++D+ +G L+ DL+GH + V + Sbjct: 150 AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGR--LLTDLKGHTNYITSVTVSPD 207 Query: 69 MYGNILASCSYDRKVIIWKE---------------------ENGTWEKTHEHSG------ 101 G++ AS D +W N W G Sbjct: 208 --GSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDL 265 Query: 102 ----------------HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG 136 + + A G L G +D I + + + Sbjct: 266 ENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 >5OQL-d nrPDB Length = 446 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 48/195 (24%), Positives = 74/195 (37%), Gaps = 8/195 (4%) Query: 17 HDAQMDYYGTR-LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 + + LA S D ++ IFD RN + L +GH V V ++ G L Sbjct: 243 NRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQ-KGHVAAVMDVEFSP--TGEELV 299 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 S SYDR + +W+ + G + H+ V W D IL GS DG + L Sbjct: 300 SGSYDRTIRLWRRDAGHSRDVY-HTKRMQRVFRTMWT-MDSKYIL-TGSDDGNVRLWRAN 356 Query: 136 GEGQWEVKKINNAHTIGC-NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 + VK + NA+ +P + P +KK + L + Sbjct: 357 ASERSGVKATRQRQALEYNNALLDRYGHLPEIRRIRRHRHLPKVVKKATEIKREELAAIK 416 Query: 195 REEEDGQWKEEQKLE 209 R EE+ + +K E Sbjct: 417 RREENERKHSNKKYE 431 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 89/309 (28%), Gaps = 37/309 (11%) Query: 8 VDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 + H ++ D +A+ S D VK++D+ + H V + + Sbjct: 61 LGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRV-AAHNNIVKGLTFT 119 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 + L SC+ D + +W T + + + + H A S Sbjct: 120 NDKK---LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYT-SLSFHRSANTFAASSGQ 174 Query: 127 GAISLLTYTGEGQWE-------VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 G I + + V I + S+I I Sbjct: 175 GCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVI 234 Query: 180 KKFASGGCDNLI----------------KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 K C+ ++ ++ + K + H V DV ++P+ Sbjct: 235 KTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPT 294 Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGD 283 + S S D + +W D K V+ W++ + + D Sbjct: 295 ----GEELVSGSYDRTIRLWRRDAGHSRDVYHT---KRMQRVFRTMWTMDSKYILTGSDD 347 Query: 284 NKVTLWKES 292 V LW+ + Sbjct: 348 GNVRLWRAN 356 >6CHG-A nrPDB Length = 312 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 107/293 (36%), Gaps = 31/293 (10%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 S + + T+H++ I+ +A+ S D +V+I + G I L GH PV Sbjct: 44 SKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHIIYG---RIRRLMGHTAPVIS 100 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + + + GNIL S S D + W +GT KT S H +V S+ P IL+ Sbjct: 101 ICYNN--KGNILCSSSMDESIKEWHVLSGTALKT--MSAHSDAVVSIDI-PKFDSSILSS 155 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 GS DG I + + + W + ++ + + K Sbjct: 156 GSYDGLIRIFDTESGHCLKTLTYDKD---------W---IAEDGVVPISTVKFSRNGKFL 203 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT-----STIASCSQD 237 DN++KLW L H + + + + L + S + Sbjct: 204 LVKSLDNVVKLWEYTRGT--VVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDS 261 Query: 238 GRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 G + +W + + + + + +S S + + +A + + L++ Sbjct: 262 GSMCVWNVYSKN----LVQKIDEKHRNSPLISISASYDKVATLSLNGECNLFR 310 Score = 67.6 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 76/245 (31%), Gaps = 54/245 (22%) Query: 68 PMYGNILASC--SYDRKV---------IIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 P G I SC S D ++ ++++ + K + H +N +CW+P Sbjct: 10 PASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLT--TTHKECINCLCWSPDSK 67 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +A GS D + + + G S Sbjct: 68 --CIASGSEDFTVEITHIIYG---------------------RIRRLMGHTAPVISICYN 104 Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 N S D IK W K + AHSD V + +S ++S S Sbjct: 105 NKGNILCSSSMDESIKEWHVLSGTALK---TMSAHSDAVVSID---IPKFDSSILSSGSY 158 Query: 237 DGRVFIWTCDDASGNMWSPKLLHKFNDVV--------WHVSWSITANILAVSGGDNKVTL 288 DG + I+ + K L D + V +S L V DN V L Sbjct: 159 DGLIRIFDTESGH----CLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKL 214 Query: 289 WKESV 293 W+ + Sbjct: 215 WEYTR 219 >2YNP-A nrPDB Length = 604 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 86/270 (31%), Gaps = 36/270 (13%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 E + + + S D +++F+ G +++ D H + +A HP Sbjct: 55 ETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVV--DFEAHPDYIRSIA-VHPTKPY 111 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 +L S S D V +W EN W GH+ V V + P D A G D + + Sbjct: 112 VL-SGSDDLTVKLWNWEN-NWALEQTFEGHEHFVMCVAFNPKDPST-FASGCLDRTVKVW 168 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + + G N V + P + D IK Sbjct: 169 SLGQ--STPNFTLTTGQERGVNYVDYYPLP---------------DKPYMITASDDLTIK 211 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 +W + LE H V + P++ I S S+DG + IW Sbjct: 212 IWDYQ---TKSCVATLEGHMSNVSFAVFHPTLP----IIISGSEDGTLKIWNSSTYKVEK 264 Query: 253 WSPKLLHKFNDVVWHVSWSITA--NILAVS 280 L + W ++ T N +A Sbjct: 265 TLNVGLERS----WCIATHPTGRKNYIASG 290 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 80/228 (35%), Gaps = 28/228 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +H D I + + + S D +VK+++ N L GHE V VA+ +P Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN-NWALEQTFEGHEHFVMCVAF-NPKD 152 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + AS DR V +W T T +G + VN V + P + S D I Sbjct: 153 PSTFASGCLDRTVKVWSLGQSTPNFTLT-TGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + Y + + H + + P + SG D Sbjct: 212 IWDYQTKSCVATLE---GHMSNVSFAVFHPT-----------------LPIIISGSEDGT 251 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG 238 +K+W +K E+ L + +A P+ + IAS +G Sbjct: 252 LKIWN---SSTYKVEKTLNVGLERSWCIATHPTGR--KNYIASGFDNG 294 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 87/281 (30%), Gaps = 36/281 (12%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 D + + T V++++ Q+ + ++ E PV + N Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVELWNYET--QVEVRSIQVTETPVRAGKFI--ARKN 68 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 + S D ++ ++ G EK + H + S+ P + GS D + L Sbjct: 69 WIIVGSDDFRIRVFNYNTG--EKVVDFEAHPDYIRSIAVHP--TKPYVLSGSDDLTVKLW 124 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + E W +++ H V++ P FASG D +K Sbjct: 125 NW--ENNWALEQTFEGHEHFVMCVAFNP----------------KDPSTFASGCLDRTVK 166 Query: 193 LWREEEDGQWKEEQKLE-AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN 251 +W + L V V + P P + + S D + IW S Sbjct: 167 VWSLGQS---TPNFTLTTGQERGVNYVDYYPLPDKP--YMITASDDLTIKIWDYQTKS-- 219 Query: 252 MWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 L V + T I+ D + +W S Sbjct: 220 --CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSS 258 >3C9C-A nrPDB Length = 432 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 100/309 (32%), Gaps = 48/309 (15%) Query: 7 TVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDV--------RNGGQILIADLRGHE 57 + +HE ++ A+ +AT + V +FD +G LRGH+ Sbjct: 124 EIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQ 183 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTH-----EHSGHDSSVNSVCWA 112 + ++W + G L S S D + +W E +GH + V V W Sbjct: 184 KEGYGLSWNPNLNG-YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 + + D + + + +AHT N +S+ P Sbjct: 243 LLHES-LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS---------- 291 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 A+G D + LW + E+H D + V W+P + +A Sbjct: 292 ------EFILATGSADKTVALWDLRN--LKLKLHSFESHKDEIFQVQWSPH---NETILA 340 Query: 233 SCSQDGRVFIWTC----------DDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSG 281 S D R+ +W D G + + SW+ I+ Sbjct: 341 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 400 Query: 282 GDNKVTLWK 290 DN + +W+ Sbjct: 401 EDNIMQVWQ 409 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 78/208 (37%), Gaps = 32/208 (15%) Query: 5 INTVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRGHEGPVWQ 62 + T H ++ D + + + + D+ + I+D RN + H V Sbjct: 225 AKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 284 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 +++ +P ILA+ S D+ V +W N K H H + V W+PH+ ILA Sbjct: 285 LSF-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHNE-TILAS 341 Query: 123 GSSDGAISLLTYT-----------GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 +D + + + +G E+ I+ HT + SW P Sbjct: 342 SGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE--------- 392 Query: 172 SGQKPNYIKKFASGGCDNLIKLWREEED 199 S DN++++W+ E+ Sbjct: 393 -------PWIICSVSEDNIMQVWQMAEN 413 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 93/264 (35%), Gaps = 37/264 (14%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWK--------EENGTWEKTHEHSGHDSSVN 107 HEG V + + P ++A+ + V+++ E +G + GH Sbjct: 129 HEGEVNRARYM-PQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 108 SVCWAPHDYGLILACGSSDGAISLLTYTGEGQ----WEVKKINNAHTIGCNAVSWAPAVV 163 + W P+ G +L S D I L + + K I HT V+W Sbjct: 188 GLSWNPNLNGYLL-SASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLL-- 244 Query: 164 PGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 + F S D + +W + K ++AH+ V +++ P Sbjct: 245 --------------HESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPY 290 Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG 282 +A+ S D V +W + + S D ++ V WS ILA SG Sbjct: 291 SEF---ILATGSADKTVALWDLRNLKLKLHS---FESHKDEIFQVQWSPHNETILASSGT 344 Query: 283 DNKVTLWKESVDGQWVCISDVNKG 306 D ++ +W S G+ D G Sbjct: 345 DRRLHVWDLSKIGEEQSTEDAEDG 368 >3CFV-B nrPDB Length = 414 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 102/309 (33%), Gaps = 48/309 (15%) Query: 7 TVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDV--------RNGGQILIADLRGHE 57 + +HE ++ A+ +AT + V +FD +G LRGH+ Sbjct: 120 EIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQ 179 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHE-----HSGHDSSVNSVCWA 112 + ++W + G L S S D V +W G E +GH + V V W Sbjct: 180 KEGYGLSWNSNLSG-HLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWH 238 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 + + D + + + + +AHT N +S+ P Sbjct: 239 LLHES-LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS---------- 287 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 A+G D + LW + E+H D + V W+P + +A Sbjct: 288 ------EFILATGSADKTVALWDLRN--LKLKLHTFESHKDEIFQVHWSPH---NETILA 336 Query: 233 SCSQDGRVFIWTC----------DDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSG 281 S D R+ +W D G + + SW+ ++ Sbjct: 337 SSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 396 Query: 282 GDNKVTLWK 290 DN + +W+ Sbjct: 397 EDNIMQIWQ 405 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 80/208 (38%), Gaps = 32/208 (15%) Query: 5 INTVDTSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQ 62 + T H ++ D + + + + D+ + I+D R+ + L H V Sbjct: 221 AKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNC 280 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 +++ +P ILA+ S D+ V +W N K H H + V W+PH+ ILA Sbjct: 281 LSF-NPYSEFILATGSADKTVALWDLRNLKL-KLHTFESHKDEIFQVHWSPHNE-TILAS 337 Query: 123 GSSDGAISLLTYT-----------GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 +D +++ + +G E+ I+ HT + SW P Sbjct: 338 SGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNE--------- 388 Query: 172 SGQKPNYIKKFASGGCDNLIKLWREEED 199 S DN++++W+ E+ Sbjct: 389 -------PWVICSVSEDNIMQIWQMAEN 409 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 51/264 (19%), Positives = 90/264 (34%), Gaps = 37/264 (14%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWK--------EENGTWEKTHEHSGHDSSVN 107 HEG V + + P +I+A+ + V+++ + +G GH Sbjct: 125 HEGEVNRARYM-PQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 108 SVCWAPHDYGLILACGSSDGAISLLTY----TGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 + W + G +L S D + L + K I H+ V+W Sbjct: 184 GLSWNSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLL-- 240 Query: 164 PGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 + F S D + +W + K ++AH+ V +++ P Sbjct: 241 --------------HESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPY 286 Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG 282 +A+ S D V +W + + D ++ V WS ILA SG Sbjct: 287 SEF---ILATGSADKTVALWDLRNLKLKL---HTFESHKDEIFQVHWSPHNETILASSGT 340 Query: 283 DNKVTLWKESVDGQWVCISDVNKG 306 D ++ +W S G+ D G Sbjct: 341 DRRLNVWDLSKIGEEQSAEDAEDG 364 >5Y1U-A nrPDB Length = 456 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 61/331 (18%), Positives = 109/331 (32%), Gaps = 51/331 (15%) Query: 7 TVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDV--------RNGGQILIADLRGHE 57 + +HE ++ A+ +AT + V +FD +G LRGH+ Sbjct: 149 EIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQ 208 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWE-----KTHEHSGHDSSVNSVCWA 112 + ++W + G L S S D + +W E +GH + V V W Sbjct: 209 KEGYGLSWNPNLSG-HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH 267 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 + + D + + + +AHT N +S+ P Sbjct: 268 LLHES-LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS---------- 316 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 A+G D + LW + E+H D + V W+P + +A Sbjct: 317 ------EFILATGSADKTVALWDLRN--LKLKLHSFESHKDEIFQVQWSPH---NETILA 365 Query: 233 SCSQDGRVFIWTC----------DDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSG 281 S D R+ +W D G + + SW+ ++ Sbjct: 366 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 425 Query: 282 GDNKVTLWKES---VDGQWVCISDVNKGQGS 309 DN + +W+ + + + S +GQGS Sbjct: 426 EDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 456 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 45/211 (21%), Positives = 81/211 (38%), Gaps = 32/211 (15%) Query: 2 VSVINTVDTSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVR-NGGQILIADLRGHEGP 59 V T+ T H ++ D + + + + D+ + I+D R N + H Sbjct: 247 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 306 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 V +++ +P ILA+ S D+ V +W N K H H + V W+PH+ I Sbjct: 307 VNCLSF-NPYSEFILATGSADKTVALWDLRNLKL-KLHSFESHKDEIFQVQWSPHNE-TI 363 Query: 120 LACGSSDGAISLLTYT-----------GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 LA +D +++ + +G E+ I+ HT + SW P Sbjct: 364 LASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE------ 417 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEED 199 S DN++++W+ E+ Sbjct: 418 ----------PWVICSVSEDNIMQVWQMAEN 438 >2AQ5-A nrPDB Length = 402 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 30/133 (22%), Positives = 55/133 (41%), Gaps = 9/133 (6%) Query: 7 TVDTSHEDMIHDAQM-DYYGTRLATCSSDRSVKIFDVRNGG-----QILIADLRGHEGPV 60 + H + D + +A+ S D +V ++++ +GG + + L GH V Sbjct: 75 PLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRV 134 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 VAW HP N+L S D +++W G T H ++ SV W+ G ++ Sbjct: 135 GIVAW-HPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRD--GALI 191 Query: 121 ACGSSDGAISLLT 133 D + ++ Sbjct: 192 CTSCRDKRVRVIE 204 Score = 79.9 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 44/217 (20%), Positives = 74/217 (34%), Gaps = 33/217 (15%) Query: 100 SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW----EVKKINNAHTIGCNA 155 GH + V + W PH+ ++A GS D + + G E HT Sbjct: 78 CGHTAPVLDIAWCPHN-DNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 156 VSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWV 215 V+W P S GCDN+I +W G + H D + Sbjct: 137 VAWHP----------------TAQNVLLSAGCDNVILVWDVG-TGAAVLTLGPDVHPDTI 179 Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPK-LLHKFNDVVWHVSWSITA 274 V W+ + I + +D RV + + G + + K H+ V H + Sbjct: 180 YSVDWS----RDGALICTSCRDKRVRV--IEPRKGTVVAEKDRPHEGTRPV-HAVFVSEG 232 Query: 275 NILAVS---GGDNKVTLWKESVDGQWVCISDVNKGQG 308 IL + +V LW + + + +++ G Sbjct: 233 KILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSG 269 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 4/128 (3%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEG--PVWQVAWAHPM 69 H D I+ G + T D+ V++ + R G + D R HEG PV V + Sbjct: 175 HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKD-RPHEGTRPVHAVFVSEGK 233 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 S +R+V +W ++ + + S V + P D ++ CG D +I Sbjct: 234 ILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDP-DTNIVYLCGKGDSSI 292 Query: 130 SLLTYTGE 137 T E Sbjct: 293 RYFEITSE 300 >5Y88-O nrPDB Length = 451 Score = 110 bits (275), Expect = 6e-25, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 83/242 (34%), Gaps = 43/242 (17%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + + +AT D +K++D+R +I + L GH+GP+ QV Sbjct: 222 GHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRT--RIPVITLVGHKGPINQVQCTP--V 277 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + S S D V +W G K H H SV + P ++ + AC + Sbjct: 278 DPQVVSSSTDATVRLWDVVAGKTMKVLTH--HKRSVRATALHPKEFSVASACTDDIRSWG 335 Query: 131 L--------LTYTGEGQWEVKKINNAHTI----------------GCNAVSWAPAVVPGS 166 L G IN + G S A + GS Sbjct: 336 LAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGS 395 Query: 167 LIDQPSGQKPNYIK---KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 L + S + K + +G D IK+W+++E + E +AW P+ Sbjct: 396 LEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEP----------GLAWNPN 445 Query: 224 IG 225 + Sbjct: 446 LS 447 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 92/293 (31%), Gaps = 50/293 (17%) Query: 8 VDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 V H + +D T S+D ++K++D+ G L L GH V VA + Sbjct: 134 VINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGK--LKTTLAGHVMTVRDVAVS 191 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 L S S D+ V W E + ++ GH S V +V P ++A D Sbjct: 192 DRHP--YLFSVSEDKTVKCWDLEKNQIIR--DYYGHLSGVRTVSIHP--TLDLIATAGRD 245 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I L + P + S Sbjct: 246 SVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDP--------------------QVVSSS 285 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D ++LW K L H VR A P S ++C+ D + W Sbjct: 286 TDATVRLWDVVAGKTMKV---LTHHKRSVRATALHP---KEFSVASACTDD--IRSWGLA 337 Query: 247 DASGNMWSPKLLHKFNDV----VWHVSWSITANILAVSGGDNKVTLWKESVDG 295 + S LL F + +S + + A GGDN V + + G Sbjct: 338 EGS-------LLTNFESEKTGIINTLSINQDDVLFA--GGDNGVLSFYDYKSG 381 Score = 98.8 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 74/244 (30%), Gaps = 37/244 (15%) Query: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSS 105 L + GH G V VA P+ + S D + +W G + T +GH + Sbjct: 128 PWKLSRVINGHLGWVRCVAID-PVDNEWFITGSNDTTMKVWDLATGKLKTT--LAGHVMT 184 Query: 106 VNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPG 165 V V + D L S D + ++ + H G VS P Sbjct: 185 VRDVAVS--DRHPYLFSVSEDKTVKCWDLEKN---QIIRDYYGHLSGVRTVSIHPT---- 235 Query: 166 SLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 + A+ G D++IKLW L H + V P Sbjct: 236 -------------LDLIATAGRDSVIKLWDM---RTRIPVITLVGHKGPINQVQCTP--- 276 Query: 226 LPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNK 285 + S S D V +W K+L V + +A + D+ Sbjct: 277 -VDPQVVSSSTDATVRLWDVVAGKT----MKVLTHHKRSVRATALHPKEFSVASACTDD- 330 Query: 286 VTLW 289 + W Sbjct: 331 IRSW 334 Score = 81.8 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 76/248 (30%), Gaps = 35/248 (14%) Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 P L Y++ + E + W+ + +GH V V P D GS+D Sbjct: 103 QPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEW-FITGSND 161 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 + + ++K H + V+ + S Sbjct: 162 TTMKVWDLATG---KLKTTLAGHVMTVRDVA-----------------VSDRHPYLFSVS 201 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D +K W E++ + + H VR V+ P++ L IA+ +D + +W Sbjct: 202 EDKTVKCWDLEKN---QIIRDYYGHLSGVRTVSIHPTLDL----IATAGRDSVIKLWDMR 254 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 L + V + + S D V LW + + Sbjct: 255 TRIP----VITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAG---KTMKVLTHH 307 Query: 307 QGSVSASI 314 + SV A+ Sbjct: 308 KRSVRATA 315 >5L9T-R nrPDB Length = 493 Score = 110 bits (274), Expect = 8e-25, Method: Composition-based stats. Identities = 44/238 (18%), Positives = 86/238 (36%), Gaps = 37/238 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + +L++ S DR + D+R L+GH V + W+ Sbjct: 269 GHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH- 325 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS-DGAI 129 +LAS D K+++W + + +++ H ++V ++ W+PH +GL+ + G + D I Sbjct: 326 -QLLASGGNDNKLLVWN--HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCI 382 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFAS--GGC 187 + + ++W+ + + S G Sbjct: 383 RFWNTLTGQPLQCIDTGSQ----VCNLAWS-----------------KHANELVSTHGYS 421 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 N I +W+ + KL HS V +A +P I + + D + W Sbjct: 422 QNQILVWKYPS---LTQVAKLTGHSYRVLYLAMSPD----GEAIVTGAGDETLRFWNV 472 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 87/276 (31%), Gaps = 35/276 (12%) Query: 14 DMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNI 73 D + G +A + V+I+D G + ++ L GH V +AW Sbjct: 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK--LSMLEGHTARVGALAW----NAEQ 283 Query: 74 LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 L+S S DR ++ + GH V + W+ +LA G +D + + Sbjct: 284 LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ--LLASGGNDNKLLVWN 341 Query: 134 YTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKL 193 + + H A++W+P + G D I+ Sbjct: 342 H---SSLSPVQQYTEHLAAVKAIAWSPHQH--------------GLLASGGGTADRCIRF 384 Query: 194 WREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMW 253 W + V ++AW+ ST ++ +W ++ Sbjct: 385 WNTLTGQPLQCIDT----GSQVCNLAWSKHANELVSTHGYSQ--NQILVW----KYPSLT 434 Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 L + V +++ S + GD + W Sbjct: 435 QVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470 Score = 88.7 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 93/283 (32%), Gaps = 41/283 (14%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 +D + +D+ + + V ++ + DL V V W+ GN Sbjct: 185 QDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWS--ERGN 242 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ++A ++ V IW G K GH + V ++ W L+ GS D I L Sbjct: 243 LVAVGTHKGFVQIWDAAAGK--KLSMLEGHTARVGALAWNAEQ----LSSGSRDRMI-LQ 295 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + ++ H + W+ + ASGG DN + Sbjct: 296 RDIRTPPLQSERRLQGHRQEVCGLKWSTDH-----------------QLLASGGNDNKLL 338 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS--QDGRVFIWTCDDASG 250 +W Q+ H V+ +AW+P +AS D + W Sbjct: 339 VWNH---SSLSPVQQYTEHLAAVKAIAWSPHQHG---LLASGGGTADRCIRFWNTLTGQP 392 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAV--SGGDNKVTLWKE 291 + V +++WS AN L N++ +WK Sbjct: 393 -LQCIDT----GSQVCNLAWSKHANELVSTHGYSQNQILVWKY 430 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 43/221 (19%), Positives = 78/221 (35%), Gaps = 36/221 (16%) Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 V +W + + S SV SV W+ + G ++A G+ G + + + Sbjct: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWS--ERGNLVAVGTHKGFVQIWDAAAGKK--- 263 Query: 143 KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQW 202 + HT A++W ++ +SG D +I L R+ Sbjct: 264 LSMLEGHTARVGALAWNA-------------------EQLSSGSRDRMI-LQRDIRTPPL 303 Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 + E++L+ H V + W+ +AS D ++ +W S + + Sbjct: 304 QSERRLQGHRQEVCGLKWSTDH----QLLASGGNDNKLLVWNHSSLSP----VQQYTEHL 355 Query: 263 DVVWHVSWSI-TANILAVSGG--DNKVTLWKESVDGQWVCI 300 V ++WS +LA GG D + W CI Sbjct: 356 AAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI 396 Score = 35.2 bits (79), Expect = 0.041, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 41/103 (39%), Gaps = 8/103 (7%) Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSIT 273 ++ V W+ S+ + + + +C V++W+ + + D V V WS Sbjct: 189 YLNLVDWS-SLNVLSVGLGTC-----VYLWSACTSQVTRLCDLSVEG--DSVTSVGWSER 240 Query: 274 ANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITE 316 N++AV V +W + + + G+++ + + Sbjct: 241 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 283 Score = 33.3 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 7/33 (21%), Positives = 15/33 (45%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV 42 T H + M G + T + D +++ ++V Sbjct: 440 TGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 >5G04-R nrPDB Length = 499 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 94/276 (34%), Gaps = 34/276 (12%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 I G LA +S V+++DV+ Q + ++ H V ++W IL+ Sbjct: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARVGSLSW----NSYILS 282 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL-TY 134 S S + SGH V + WAP G LA G +D +++ + Sbjct: 283 SGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSA 339 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 GEG W + H AV+W P + + G D I++W Sbjct: 340 PGEGGWVPLQTFTQHQGAVKAVAWCP--------------WQSNVLATGGGTSDRHIRIW 385 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 ++AHS V + W+P S ++ IW M Sbjct: 386 NV---CSGACLSAVDAHSQ-VCSILWSPHYKELIS--GHGFAQNQLVIW----KYPTMAK 435 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 L V ++ S +A + D + LW+ Sbjct: 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 86/241 (35%), Gaps = 38/241 (15%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 TSH + + Y L++ S + DVR +A L GH V + WA Sbjct: 265 TSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD- 320 Query: 70 YGNILASCSYDRKVIIWKEENGT--WEKTHEHSGHDSSVNSVCWAPHDYGLILACGS-SD 126 G LAS D V +W G W + H +V +V W P ++ G SD Sbjct: 321 -GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 379 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + ++ ++ W+P + K+ SG Sbjct: 380 RHIRIWNVCSGACLSAVDAHSQ----VCSILWSP-----------------HYKELISGH 418 Query: 187 --CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 N + +W+ + +L+ H+ V + +P +T+AS + D + +W Sbjct: 419 GFAQNQLVIWKYPTMAK---VAELKGHTSRVLSLTMSPD----GATVASAAADETLRLWR 471 Query: 245 C 245 C Sbjct: 472 C 472 Score = 93.0 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 76/230 (33%), Gaps = 37/230 (16%) Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 V W+ GN+LA D V +W +G + + ++SV W G LA Sbjct: 190 VDWSS---GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAV 243 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G+S + L + + + +H+ ++SW ++ + + Sbjct: 244 GTSSAEVQLWDVQQQKR---LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE- 299 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 L HS V + WAP +AS D V + Sbjct: 300 --------------------HHVATLSGHSQEVCGLRWAPD----GRHLASGGNDNLVNV 335 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG--DNKVTLW 289 W G + + V V+W +N+LA GG D + +W Sbjct: 336 WPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 75/207 (36%), Gaps = 35/207 (16%) Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 N V W+ G +LA D ++ L + + ++ ++ ++V+W Sbjct: 188 NLVDWS---SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEY-ISSVAW-------- 234 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 A G ++LW ++ + + + +HS V ++W Sbjct: 235 ---------IKEGNYLAVGTSSAEVQLWDVQQQKRL---RNMTSHSARVGSLSWNS---- 278 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 ++S S+ G + A + L + V + W+ LA G DN V Sbjct: 279 --YILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 Query: 287 TLW-KESVDGQWVCISDVNKGQGSVSA 312 +W +G WV + + QG+V A Sbjct: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKA 360 >4V7E-Bg nrPDB Length = 380 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 96/312 (30%), Gaps = 38/312 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H ++ + + S D + +++ + ++ H V + A+A Sbjct: 64 GHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKT--HAIKLHCPWVMECAFAP--N 119 Query: 71 GNILASCSYDRKVIIWKE-----ENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSS 125 G +A D I+ +G + +GH +S + P L GS Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQE-TRLITGSG 178 Query: 126 DGAISLLTYTGEGQWEV--KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA 183 D L T + + + + HT ++S F Sbjct: 179 DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA----------------NMFI 222 Query: 184 SGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 SG CD ++LW + + H + V + P + S DG ++ Sbjct: 223 SGSCDTTVRLWDLRITSR--AVRTYHGHEGDINSVKFFPD----GQRFGTGSDDGTCRLF 276 Query: 244 TCDDASGNM---WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 P +V V++SI+ +L + +W + + + Sbjct: 277 DMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNL 336 Query: 301 SDV-NKGQGSVS 311 + N +G +S Sbjct: 337 GTLQNSHEGRIS 348 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 81/250 (32%), Gaps = 30/250 (12%) Query: 45 GGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDS 104 + L+GH G V+ + W N + S S D ++I+W +KTH H Sbjct: 54 TDLVCCRTLQGHSGKVYSLDWTPEK--NWIVSASQDGRLIVWNALT--SQKTHAIKLHCP 109 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTG----EGQWEVKKINNAHTIGCNAVSWAP 160 V +AP+ G +ACG D A S+ + +G V ++ H ++ + P Sbjct: 110 WVMECAFAPN--GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVP 167 Query: 161 AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAW 220 + + +G D LW GQ E S DV Sbjct: 168 ----------------DQETRLITGSGDQTCVLWDVT-TGQRISIFGSEFPSGHTADVLS 210 Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVS 280 L + S S D V +W S + + H + V + Sbjct: 211 LSINSLNANMFISGSCDTTVRLWDLRITS---RAVRTYHGHEGDINSVKFFPDGQRFGTG 267 Query: 281 GGDNKVTLWK 290 D L+ Sbjct: 268 SDDGTCRLFD 277 Score = 98.0 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 81/251 (32%), Gaps = 26/251 (10%) Query: 5 INTVDTSHEDMIHDAQMDYY-GTRLATCSSDRSVKIFDVRNGGQILIADLR---GHEGPV 60 ++ V T H+ Q TRL T S D++ ++DV G +I I GH V Sbjct: 149 VSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADV 208 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 ++ + N+ S S D V +W T + GH+ +NSV + P G Sbjct: 209 LSLSINS-LNANMFISGSCDTTVRLWDLRI-TSRAVRTYHGHEGDINSVKFFPD--GQRF 264 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 GS DG L Q +V P L S + Sbjct: 265 GTGSDDGTCRLFDMRTGHQLQVYNRE-------------PDRNDNELPIVTSVAFSISGR 311 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLE-AHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 +G + +W L+ +H + + + S + + S D Sbjct: 312 LLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSD----GSALCTGSWDKN 367 Query: 240 VFIWTCDDASG 250 + IW Sbjct: 368 LKIWAFSGHRK 378 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 42/116 (36%), Gaps = 12/116 (10%) Query: 201 QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK 260 + L+ HS V + W P + I S SQDGR+ +W + + Sbjct: 55 DLVCCRTLQGHSGKVYSLDWTP----EKNWIVSASQDGRLIVWNALTSQK----THAIKL 106 Query: 261 FNDVVWHVSWSITANILAVSGGDNKVTLW----KESVDGQWVCISDVNKGQGSVSA 312 V +++ +A G D+ +++ + DG + +G S+ Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASS 162 Score = 37.9 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 25/49 (51%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL 49 MV + T+ SHE I + G+ L T S D+++KI+ +I+ Sbjct: 332 MVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHRKIV 380 >5WBU-D nrPDB Length = 328 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 96/283 (33%), Gaps = 30/283 (10%) Query: 12 HEDM-IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H+D ++ ++ + +A + ++++D+ + I G + V + Sbjct: 42 HQDSQVNALEVTPDRSMIAAAGY-QHIRMYDLNSNNPNPIISYDGVNKNIASVGFH--ED 98 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G + + D IW + + ++ +N VC P+ LI+ G GAI Sbjct: 99 GRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAELIV--GDQSGAIH 155 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + +++ + + P S + + Y+ G D + Sbjct: 156 IWDLKTDHN---EQLIPEPEVSITSAHIDP---DASYMAAVNSTGNCYVWNLTGGIGDEV 209 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 Q + K+ AH+ + ++P L +A+CS D IW + S Sbjct: 210 ---------TQLIPKTKIPAHTRYALQCRFSPDSTL----LATCSADQTCKIWRTSNFSL 256 Query: 251 NMWSPKLLHK----FNDVVWHVSWSITANILAVSGGDNKVTLW 289 +W ++S + + + DN LW Sbjct: 257 MTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 299 Score = 81.4 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 41/292 (14%), Positives = 94/292 (32%), Gaps = 40/292 (13%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 LAT D +V+ + +G I ++ + V + +++A+ Y + ++ Sbjct: 16 ILATAGYDHTVRFWQAHSG--ICTRTVQHQDSQVNALEVTPDR--SMIAAAGYQH-IRMY 70 Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 + + G + ++ SV + H+ G + G D + + ++I Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRN-LQCQRIF 127 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 + N V P + G I +W + D EQ Sbjct: 128 QVNAP-INCVCLHPNQA-----------------ELIVGDQSGAIHIWDLKTD---HNEQ 166 Query: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH----KFN 262 + + P S +A+ + G ++W G+ + + Sbjct: 167 LIPEPEVSITSAHIDPD----ASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 222 Query: 263 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASI 314 +S + +LA D +W+ S + +++++ G+ S Sbjct: 223 RYALQCRFSPDSTLLATCSADQTCKIWRTS---NFSLMTELSIKSGNPGESS 271 Score = 80.6 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 39/257 (15%), Positives = 75/257 (29%), Gaps = 24/257 (9%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 I G + T D + +I+D+R+ + P+ V HP ++ Sbjct: 90 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCL-HPNQAELIV 147 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 + IW + E+ + S+ S P D + A S+ G + T Sbjct: 148 -GDQSGAIHIWDLKTDHNEQL--IPEPEVSITSAHIDP-DASYMAAVNST-GNCYVWNLT 202 Query: 136 GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR 195 G EV ++ +P + A+ D K+WR Sbjct: 203 GGIGDEVTQLIPK------------TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 250 Query: 196 EEEDGQWKEEQKLEAH-SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 E + + R W + + I + S D +W + Sbjct: 251 TSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK--- 307 Query: 255 PKLLHKFNDVVWHVSWS 271 + V ++++ Sbjct: 308 -REYGGHQKAVVCLAFN 323 Score = 68.3 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 46/114 (40%), Gaps = 10/114 (8%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR------GHE 57 + T +H + T LATCS+D++ KI+ N + ++ Sbjct: 213 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 272 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 G +W A++ + + S D +W E G ++ E+ GH +V + + Sbjct: 273 GWMWGCAFS--GDSQYIVTASSDNLARLWCVETGEIKR--EYGGHQKAVVCLAF 322 Score = 33.7 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 8/70 (11%), Positives = 26/70 (37%), Gaps = 5/70 (7%) Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 ++G +A+ D V W + + + V + + +++A +G Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSG----ICTRTVQHQDSQVNALEVTPDRSMIAAAGY 64 Query: 283 DNKVTLWKES 292 + + ++ + Sbjct: 65 QH-IRMYDLN 73 >4GGA-A nrPDB Length = 420 Score = 107 bits (266), Expect = 7e-24, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 94/276 (34%), Gaps = 34/276 (12%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 I G LA +S V+++DV+ Q + ++ H V ++W IL+ Sbjct: 150 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARVGSLSW----NSYILS 203 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL-TY 134 S S + SGH V + WAP G LA G +D +++ + Sbjct: 204 SGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSA 260 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 GEG W + H AV+W P + + G D I++W Sbjct: 261 PGEGGWVPLQTFTQHQGAVKAVAWCP--------------WQSNVLATGGGTSDRHIRIW 306 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 ++AHS V + W+P S ++ IW M Sbjct: 307 NV---CSGACLSAVDAHSQ-VCSILWSPHYKELIS--GHGFAQNQLVIW----KYPTMAK 356 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 L V ++ S +A + D + LW+ Sbjct: 357 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 392 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 86/241 (35%), Gaps = 38/241 (15%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 TSH + + Y L++ S + DVR +A L GH V + WA Sbjct: 186 TSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD- 241 Query: 70 YGNILASCSYDRKVIIWKEENGT--WEKTHEHSGHDSSVNSVCWAPHDYGLILACGS-SD 126 G LAS D V +W G W + H +V +V W P ++ G SD Sbjct: 242 -GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 300 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + ++ ++ W+P + K+ SG Sbjct: 301 RHIRIWNVCSGACLSAVDAHSQ----VCSILWSP-----------------HYKELISGH 339 Query: 187 --CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 N + +W+ + +L+ H+ V + +P +T+AS + D + +W Sbjct: 340 GFAQNQLVIWKYPTMAK---VAELKGHTSRVLSLTMSPD----GATVASAAADETLRLWR 392 Query: 245 C 245 C Sbjct: 393 C 393 Score = 90.7 bits (223), Expect = 7e-19, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 76/230 (33%), Gaps = 37/230 (16%) Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 V W+ GN+LA D V +W +G + + ++SV W G LA Sbjct: 111 VDWSS---GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAV 164 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G+S + L + + + +H+ ++SW ++ + + Sbjct: 165 GTSSAEVQLWDVQQQKR---LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE- 220 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 L HS V + WAP +AS D V + Sbjct: 221 --------------------HHVATLSGHSQEVCGLRWAPD----GRHLASGGNDNLVNV 256 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG--DNKVTLW 289 W G + + V V+W +N+LA GG D + +W Sbjct: 257 WPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 306 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 40/207 (19%), Positives = 74/207 (35%), Gaps = 35/207 (16%) Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 N V W+ G +LA D ++ L + + ++ ++ P S Sbjct: 109 NLVDWS---SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQ------------PGEYISS 152 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 + G A G ++LW ++ + + + +HS V ++W Sbjct: 153 VAWIKEG------NYLAVGTSSAEVQLWDVQQQKRL---RNMTSHSARVGSLSWNS---- 199 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 ++S S+ G + A + L + V + W+ LA G DN V Sbjct: 200 --YILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 254 Query: 287 TLW-KESVDGQWVCISDVNKGQGSVSA 312 +W +G WV + + QG+V A Sbjct: 255 NVWPSAPGEGGWVPLQTFTQHQGAVKA 281 >6Q8F-A nrPDB Length = 514 Score = 107 bits (266), Expect = 8e-24, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 92/280 (32%), Gaps = 33/280 (11%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQVAWAHPMYG 71 +D + LAT + D +K++ +++G + H V ++++ Sbjct: 265 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQ--CLRRFERAHSKGVTCLSFSKDSSQ 322 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 + S S+D+ + I ++G K E GH S VN + G + SSDG + + Sbjct: 323 --ILSASFDQTIRIHGLKSGKTLK--EFRGHSSFVNEATFT--QDGHYIISASSDGTVKI 376 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG-QKPNYIKKFASGGCDNL 190 T C+ + G+ I S P + F N Sbjct: 377 WNMK--------------TTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNT 422 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 + + + D+V A +P I +D ++ ++ Sbjct: 423 VVIMNMQGQIVRSFSSGKREGGDFV-CCALSP----RGEWIYCVGEDFVLYCFSTVTGKL 477 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + L V ++ N++A D + LWK Sbjct: 478 E----RTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 47/326 (14%), Positives = 93/326 (28%), Gaps = 42/326 (12%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGH------E 57 + + + + A+ G L T S D +++++ G + + Sbjct: 206 LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 265 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYG 117 V + ++ +LA+ + D K+ +WK ++G + E H V + ++ Sbjct: 266 DAVLCMCFSRDT--EMLATGAQDGKIKVWKIQSGQCLRRFE-RAHSKGVTCLSFSKDSSQ 322 Query: 118 LILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPN 177 ++ S D I + + K H+ N ++ Sbjct: 323 IL--SASFDQTIRIHGLKSG---KTLKEFRGHSSFVNEATF-----------------TQ 360 Query: 178 YIKKFASGGCDNLIKLWREEEDG---QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASC 234 S D +K+W + +K V V P C Sbjct: 361 DGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLP---KNPEHFVVC 417 Query: 235 SQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 ++ V I +S D V + S + G D V +V Sbjct: 418 NRSNTVVIMNMQGQIVRSFSSGKREG-GDFVC-CALSPRGEWIYCVGED-FVLYCFSTVT 474 Query: 295 GQWVCISDVNKGQGSVSASITEGQQN 320 G+ + + V QN Sbjct: 475 GKLE--RTLTVHEKDVIGIAHHPHQN 498 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 84/244 (34%), Gaps = 34/244 (13%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 + + +H + +++ + S D++++I +++G + + RGH V + Sbjct: 300 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT--LKEFRGHSSFVNEAT 357 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDS----SVNSVCWAPHDYGLIL 120 + G+ + S S D V IW + T + G + +VNSV P + Sbjct: 358 FTQD--GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKN-PEHF 414 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 + + ++ G ++ + ++ G I Y Sbjct: 415 VVCNRSNTVVIMNMQG----QIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCF 470 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 +G K E+ L H V +A P L IA+ S+DG + Sbjct: 471 STVTG-----------------KLERTLTVHEKDVIGIAHHPHQNL----IATYSEDGLL 509 Query: 241 FIWT 244 +W Sbjct: 510 KLWK 513 >5LCW-Q nrPDB Length = 374 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 94/276 (34%), Gaps = 34/276 (12%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 I G LA +S V+++DV+ Q + ++ H V ++W IL+ Sbjct: 104 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARVGSLSW----NSYILS 157 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL-TY 134 S S + SGH V + WAP G LA G +D +++ + Sbjct: 158 SGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSA 214 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 GEG W + H AV+W P + + G D I++W Sbjct: 215 PGEGGWVPLQTFTQHQGAVKAVAWCP--------------WQSNVLATGGGTSDRHIRIW 260 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 ++AHS V + W+P S ++ IW M Sbjct: 261 NV---CSGACLSAVDAHSQ-VCSILWSPHYKELIS--GHGFAQNQLVIW----KYPTMAK 310 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 L V ++ S +A + D + LW+ Sbjct: 311 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 346 Score = 101 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 86/241 (35%), Gaps = 38/241 (15%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 TSH + + Y L++ S + DVR +A L GH V + WA Sbjct: 140 TSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD- 195 Query: 70 YGNILASCSYDRKVIIWKEENGT--WEKTHEHSGHDSSVNSVCWAPHDYGLILACGS-SD 126 G LAS D V +W G W + H +V +V W P ++ G SD Sbjct: 196 -GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 254 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + ++ ++ W+P + K+ SG Sbjct: 255 RHIRIWNVCSGACLSAVDAHSQ----VCSILWSP-----------------HYKELISGH 293 Query: 187 --CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 N + +W+ + +L+ H+ V + +P +T+AS + D + +W Sbjct: 294 GFAQNQLVIWKYPTMAK---VAELKGHTSRVLSLTMSPD----GATVASAAADETLRLWR 346 Query: 245 C 245 C Sbjct: 347 C 347 Score = 89.9 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 76/230 (33%), Gaps = 37/230 (16%) Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 V W+ GN+LA D V +W +G + + ++SV W G LA Sbjct: 65 VDWSS---GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAV 118 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G+S + L + + + +H+ ++SW ++ + + Sbjct: 119 GTSSAEVQLWDVQQQKR---LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE- 174 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 L HS V + WAP +AS D V + Sbjct: 175 --------------------HHVATLSGHSQEVCGLRWAPD----GRHLASGGNDNLVNV 210 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG--DNKVTLW 289 W G + + V V+W +N+LA GG D + +W Sbjct: 211 WPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 260 Score = 57.9 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 40/207 (19%), Positives = 74/207 (35%), Gaps = 35/207 (16%) Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 N V W+ G +LA D ++ L + + ++ ++ P S Sbjct: 63 NLVDWS---SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQ------------PGEYISS 106 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 + G A G ++LW ++ + + + +HS V ++W Sbjct: 107 VAWIKEG------NYLAVGTSSAEVQLWDVQQQKRL---RNMTSHSARVGSLSWNS---- 153 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 ++S S+ G + A + L + V + W+ LA G DN V Sbjct: 154 --YILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 208 Query: 287 TLW-KESVDGQWVCISDVNKGQGSVSA 312 +W +G WV + + QG+V A Sbjct: 209 NVWPSAPGEGGWVPLQTFTQHQGAVKA 235 >2P9P-C nrPDB Length = 372 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 95/270 (35%), Gaps = 19/270 (7%) Query: 14 DMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNI 73 + I + T++A C ++ V I++ + + +L+ H G V V WA N Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD--SNR 66 Query: 74 LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 + +C DR +W + TW+ T + + V WAP++ A GS IS+ Sbjct: 67 IVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKK--FAVGSGSRVISICY 124 Query: 134 YTGEGQWEV-KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + E W V K I ++ W P V + + Sbjct: 125 FEQENDWWVCKHIKKPIRSTVLSLDWHPNSVL-LAAGSCDFKCRIFSAYIKEVEERPAPT 183 Query: 193 LWREEEDGQWKEEQKLEAHSD--WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 W E E+ S WV V ++ + S +A S D V + D Sbjct: 184 PW---GSKMPFGELMFESSSSCGWVHGVCFSAN----GSRVAWVSHDSTVCLADAD---- 232 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVS 280 + L + V++ ++++A Sbjct: 233 KKMAVATLASETLPLLAVTFITESSLVAAG 262 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 43/280 (15%), Positives = 77/280 (27%), Gaps = 39/280 (13%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKI--FDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 + + A S R + I F+ N + + V + W Sbjct: 96 NRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHP--N 153 Query: 71 GNILASCSYDRKVII----------------WKEENGTWEKTHEHSGHDSSVNSVCWAPH 114 +LA+ S D K I W + E E S V+ VC++ + Sbjct: 154 SVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSAN 213 Query: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQ 174 G +A S D + L + + ++ + V G Sbjct: 214 --GSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFT 271 Query: 175 KPNYIKKFASGGCDNLIK------LWREEEDGQWKEEQKLEA-----------HSDWVRD 217 + K + GG ++ K L E ++ E H + V Sbjct: 272 YDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQ 331 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKL 257 ++ S + DG + IW + K+ Sbjct: 332 ISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLESALKDLKI 371 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 39/103 (37%), Gaps = 6/103 (5%) Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 E+ +W + +L+ H+ V V WAP I +C D ++WT + Sbjct: 35 YEKSGNKWVQVHELKEHNGQVTGVDWAPDSNR----IVTCGTDRNAYVWTLKGRT--WKP 88 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 ++ + N V W+ AV G +++ + W Sbjct: 89 TLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDW 131 Score = 48.3 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 20/164 (12%), Positives = 39/164 (23%), Gaps = 6/164 (3%) Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWA-PAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + H + W + + + G D Sbjct: 16 WNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRN 75 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +W + L + R V WAP+ A S + I + + Sbjct: 76 AYVWTLKGRTWKPTLVILRINRA-ARCVRWAPNEKK----FAVGSGSRVISICYFEQEND 130 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 + V + W + +LA D K ++ + Sbjct: 131 WWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIK 174 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 8/78 (10%) Query: 213 DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMW-SPKLLHKFNDVVWHVSWS 271 + + AW + IA C + V I+ + SGN W L + N V V W+ Sbjct: 9 EPISCHAW----NKDRTQIAICPNNHEVHIY---EKSGNKWVQVHELKEHNGQVTGVDWA 61 Query: 272 ITANILAVSGGDNKVTLW 289 +N + G D +W Sbjct: 62 PDSNRIVTCGTDRNAYVW 79 >5WYK-BB nrPDB Length = 943 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 53/318 (16%), Positives = 102/318 (32%), Gaps = 59/318 (18%) Query: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74 + + LAT S + S+KI++++ I G + G ++ Sbjct: 393 DVRSIDISDDNKLLATAS-NGSLKIWNIKT--HKCIRTFE--CGYALTCKFLP--GGLLV 445 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 + + ++ ++ + + T E HD+++ S+ G L GS+D + + Sbjct: 446 ILGTRNGELQLFDLASSSLLDTIE-DAHDAAIWSLDLTSD--GKRLVTGSADKTVKFWDF 502 Query: 135 TGEGQWE---------VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY------- 178 E V K+++ T+ V P S Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDS 562 Query: 179 ----------------------IKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVR 216 K + D IK+W + K L AH D + Sbjct: 563 MKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKS---LFAHQDSIM 619 Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI 276 +V + P + SCS+D V W + L+ VW ++ + Sbjct: 620 NVKFLP----QSHNFFSCSKDAVVKYWD----GEKFECIQKLYAHQSEVWALAVATDGGF 671 Query: 277 LAVSGGDNKVTLWKESVD 294 + S D+ + +W+E+ D Sbjct: 672 VVSSSHDHSIRIWEETED 689 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 89/263 (33%), Gaps = 47/263 (17%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR-------NGGQILIADLRG 55 S+++T++ +H+ I + G RL T S+D++VK +D + + L+ Sbjct: 463 SLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKL 522 Query: 56 H-------EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNS 108 H + V + LA D V ++ ++ + GH V S Sbjct: 523 HHDTTLELTDDILCVRVSPD--DRYLAISLLDNTVKVFFLDSMKF--YLSLYGHKLPVLS 578 Query: 109 VCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 + + ++ S+D I + + + + + + Sbjct: 579 IDISFDSK--MIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQS--------- 627 Query: 169 DQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 F S D ++K W + +++ QKL AH V +A A G Sbjct: 628 -----------HNFFSCSKDAVVKYW---DGEKFECIQKLYAHQSEVWALAVATDGG--- 670 Query: 229 STIASCSQDGRVFIWTCDDASGN 251 + S S D + IW + Sbjct: 671 -FVVSSSHDHSIRIWEETEDQVF 692 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 61/176 (34%), Gaps = 31/176 (17%) Query: 22 DYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDR 81 LA +D +K++D+ + ++ + GH+ + + + G L S S D Sbjct: 88 HKDTDLLAVGYADGVIKVWDL--MSKTVLLNFNGHKAAITLLQF--DGTGTRLISGSKDS 143 Query: 82 KVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 141 +I+W ++ H S+ W + LI S DG I L E Sbjct: 144 NIIVWDLVGE--VGLYKLRSHKDSITGF-WCQGEDWLI--STSKDGMIKLWDLKTHQCIE 198 Query: 142 VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREE 197 + AHT C ++ + G D+ +K+W+ + Sbjct: 199 T---HIAHTGECWGLA-------------------VKDDLLITTGTDSQVKIWKLD 232 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 50/130 (38%), Gaps = 11/130 (8%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H+ I Q D GTRL + S D ++ ++D+ G++ + LR H+ + W Sbjct: 118 NGHKAAITLLQFDGTGTRLISGSKDSNIIVWDL--VGEVGLYKLRSHKDSITGF-WCQGE 174 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 + L S S D + +W + +T H H CW +L +D + Sbjct: 175 --DWLISTSKDGMIKLWDLKTHQCIET--HIAHTGE----CWGLAVKDDLLITTGTDSQV 226 Query: 130 SLLTYTGEGQ 139 + E Sbjct: 227 KIWKLDIEND 236 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 48/361 (13%), Positives = 91/361 (25%), Gaps = 85/361 (23%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 SH+D I L + S D +K++D++ I H G W +A + Sbjct: 161 SHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKT--HQCIETHIAHTGECWGLA----VK 213 Query: 71 GNILASCSYDRKVIIW--KEENGTWEKTHEHSG-----HDSSVNSVCWAPHDYGL--ILA 121 ++L + D +V IW EN G + + + Sbjct: 214 DDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFY 273 Query: 122 CGSSDGAISLLTYTGEGQ----------------WEVKKINNAHTIGCNAVSWAPAVVPG 165 ++D I E + ++I + ++ P Sbjct: 274 IQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIR 333 Query: 166 SLIDQPSGQKPNYIK---KFASGGCDNLIKLWREEEDGQ--------WKEEQKLEAHSDW 214 SL S + N I+ + + + +L+ Sbjct: 334 SLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTD 393 Query: 215 VRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS------------------------- 249 VR + I +A+ S +G + IW Sbjct: 394 VRSI----DISDDNKLLATAS-NGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILG 448 Query: 250 ------------GNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 + + + +W + + L D V W V+ Sbjct: 449 TRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSL 508 Query: 298 V 298 V Sbjct: 509 V 509 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 39/234 (16%), Positives = 71/234 (30%), Gaps = 44/234 (18%) Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSS--------VNSVCWAPHDYGLILAC 122 G ++ S D V IW + G + H +LA Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G +DG I + + V N H + + + Sbjct: 97 GYADGVIKVWDLMSK---TVLLNFNGHKAAITLLQF-----------------DGTGTRL 136 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 SG D+ I +W + KL +H D + W + S S+DG + + Sbjct: 137 ISGSKDSNIIVWDLVGE---VGLYKLRSHKDSITGF-WCQG----EDWLISTSKDGMIKL 188 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 W + W ++ + ++L +G D++V +WK ++ Sbjct: 189 WDLKTHQ----CIETHIAHTGECWGLA--VKDDLLITTGTDSQVKIWKLDIEND 236 Score = 64.5 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 80/239 (33%), Gaps = 50/239 (20%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILI---------ADLRGHEGPVWQVAWAHPMYGNILA 75 G + + D V I+D++ G + +D RG P ++LA Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARG-AKPAECTYLEAHKDTDLLA 95 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 D + +W + T +GH +++ + + G L GS D I + Sbjct: 96 VGYADGVIKVWDLMSKTV--LLNFNGHKAAITLLQF--DGTGTRLISGSKDSNIIVWDLV 151 Query: 136 GE-GQWEVKKINNAHT-IGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKL 193 GE G ++++ ++ T C W S D +IKL Sbjct: 152 GEVGLYKLRSHKDSITGFWCQGEDW-----------------------LISTSKDGMIKL 188 Query: 194 WREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 W + + + AH+ +A + + + D +V IW D + M Sbjct: 189 WDLKTH---QCIETHIAHTGECWGLAVKDDL------LITTGTDSQVKIWKLDIENDKM 238 >5XYI-g nrPDB Length = 335 Score = 104 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 107/308 (34%), Gaps = 38/308 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ---ILIADLRGHEGPVWQVAWAH 67 H I ++D L + S D+S ++ + + L GH V V+ + Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSR 90 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 + L + S+D + +W T +K GH V V ++P + +I D Sbjct: 91 D--ASHLLTSSWDSTLRLWDLSTRTTKKL--FLGHKKDVLGVTFSPCNRRII--SVGRDN 144 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + GE + E+ SW +V + D+ S A G Sbjct: 145 QVKIWNILGENKAEL-----------QCSSWVTSVACAPMADETSPLV------IAVGCW 187 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 D + +W E++ + +E +AH V + P + + D +V +W ++ Sbjct: 188 DGKVYIWSIEKEAKLIKE--FKAHDGRCTSVDFTPD----GKWVITGGSDRKVVMWLTEN 241 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 + + V V+ T + + + + +W Q + K + Sbjct: 242 GAKTISFTA-----PSPVHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHE 295 Query: 308 GSVSASIT 315 G +A T Sbjct: 296 GKRNAGRT 303 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 82/243 (33%), Gaps = 36/243 (14%) Query: 51 ADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT---WEKTHEHSGHDSSVN 107 A GH + + + N L S S D+ ++WK GH+ V+ Sbjct: 27 ATFVGHNAAIESIEIDNEH--NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 108 SVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSL 167 V + L S D + L + KK+ H V+++P Sbjct: 85 DVSLSRDASH--LLTSSWDSTLRLWDLSTR---TTKKLFLGHKKDVLGVTFSPC------ 133 Query: 168 IDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP 227 ++ S G DN +K+W + + + + S WV VA AP Sbjct: 134 -----------NRRIISVGRDNQVKIWNILGENKAELQC-----SSWVTSVACAPMADET 177 Query: 228 TST-IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 + IA DG+V+IW+ K + V ++ + G D KV Sbjct: 178 SPLVIAVGCWDGKVYIWSI---EKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKV 234 Query: 287 TLW 289 +W Sbjct: 235 VMW 237 Score = 93.0 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 53/290 (18%), Positives = 96/290 (33%), Gaps = 46/290 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + D + + L T S D +++++D+ + GH+ V V ++ Sbjct: 78 GHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKL--FLGHKKDVLGVTFSP--C 133 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD---YGLILACGSSDG 127 + S D +V IW + S V SV AP L++A G DG Sbjct: 134 NRRIISVGRDNQVKIWNILGENKAELQC----SSWVTSVACAPMADETSPLVIAVGCWDG 189 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + + E ++ K AH C +V + P K +GG Sbjct: 190 KVYIWSIEKEA--KLIKEFKAHDGRCTSVDFTP-----------------DGKWVITGGS 230 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT--- 244 D + +W E + V VA P+ + I + + +G + +W Sbjct: 231 DRKVVMWLTENGAKTISFTA----PSPVHAVAACPT----QAWICAATYEG-IAVWDIGA 281 Query: 245 ---CDDASGNMWSPKLLHKFNDVVWHV-SWSITANILAVSGGDNKVTLWK 290 D N + +W+ ++L D + W+ Sbjct: 282 KQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 Score = 72.2 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 71/242 (29%), Gaps = 30/242 (12%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH--- 67 H+ + R+ + D VKI+++ + + V VA A Sbjct: 120 GHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQ----CSSWVTSVACAPMAD 175 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 ++A +D KV IW E + E HD SV + P G + G SD Sbjct: 176 ETSPLVIAVGCWDGKVYIWSIEK-EAKLIKEFKAHDGRCTSVDFTPD--GKWVITGGSDR 232 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA-SGG 186 + + + + + +P + Q Y G Sbjct: 233 KVVMWLTENGAKT------------ISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIG 280 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 I + E ++ + +AWA S + S DG + W Sbjct: 281 AKQQI---DLVQPNFKHEGKRNAGRTPDCTCLAWAAD----GSVLYSGYNDGSIRAWEVK 333 Query: 247 DA 248 A Sbjct: 334 SA 335 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 33/95 (34%), Gaps = 5/95 (5%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-KL 257 + H+ + + I + + S S+D +W + +P Sbjct: 20 SAHFAPRATFVGHNAAIESI----EIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTR 75 Query: 258 LHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 L N V VS S A+ L S D+ + LW S Sbjct: 76 LIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLS 110 >4XFV-A nrPDB Length = 792 Score = 104 bits (258), Expect = 6e-23, Method: Composition-based stats. Identities = 58/331 (17%), Positives = 115/331 (34%), Gaps = 56/331 (16%) Query: 26 TRLATCSSDRSVKIFD-VRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 ++ + +++ ++D + + + A L+GHE V V + + + S S D V Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 88 Query: 85 IWK-EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 IWK + + + ++ ++ P +++ G +DG IS+ + Sbjct: 89 IWKFTDYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIWRQNIQND---- 140 Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN-----LIKLWREEE 198 + AH + P + S +++ K + G N + + Sbjct: 141 EFGLAHEFTIKKGFFYPLCLSLSKVEEK--------KYLLAIGGTNVNVFIASFILSDSG 192 Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT------CDDASGNM 252 + + +LE H DWV+ +A+ + S SQD + +W DD+ + Sbjct: 193 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 252 Query: 253 WSPKLLHK-----------------------FNDVVWHVSWSITANILAVSGGDNKVTLW 289 LL +D + + W + L + D + +W Sbjct: 253 KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 312 Query: 290 K-ESVDGQWVCISDVNKGQGSVSASITEGQQ 319 + + G WVC S S AS G Sbjct: 313 EPDETSGIWVC-SLRLGEMSSKGASTATGSS 342 Score = 84.1 bits (206), Expect = 6e-17, Method: Composition-based stats. Identities = 43/288 (14%), Positives = 91/288 (31%), Gaps = 61/288 (21%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRGHEGPVWQVAWAHPM 69 HE + + + + S D VKI+ + I ++ + + ++ Sbjct: 61 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS----A 116 Query: 70 YGNILASCSYDRKVIIW--KEENGTWEKTHEHSGHDSSVNSVCWA---PHDYGLILACGS 124 ++++ D + IW +N + HE + +C + + +LA G Sbjct: 117 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 176 Query: 125 SDGAISLLTYTGEG----QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 ++ + + ++ + V H ++++ PG + Sbjct: 177 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYL------------ 224 Query: 181 KFASGGCDNLIKLWR------------------EEEDGQWKEEQKLE------------A 210 SG D I+LWR + Q+K + E Sbjct: 225 -LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 283 Query: 211 HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 H DW+ + W S + + + D + +W D+ SG L Sbjct: 284 HDDWISSLQWHES----RLQLLAATADTSLMVWEPDETSGIWVCSLRL 327 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 63/200 (31%), Gaps = 20/200 (10%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRG---HEGPVW 61 I H I + G L + DR +++ + H +W Sbjct: 602 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 661 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG---HDSSVNSVCWAPH--DY 116 WA +GN+ + S D+ V +W+ + + H +V ++ Sbjct: 662 DADWAPLEFGNVFVTASRDKTVKVWRHQK-EPADDYVLEASIKHTKAVTAISIHDSMIRE 720 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 ++++ G +G I L +YT + ++N T + S K Sbjct: 721 KILISVGLENGEIYLYSYTLGKFELITQLNEDIT-----------PADKITRLRWSHLKR 769 Query: 177 NYIKKFASGGCDNLIKLWRE 196 N G D +++ Sbjct: 770 NGKLFLGVGSSDLSTRIYSL 789 Score = 71.0 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 43/245 (17%), Positives = 84/245 (34%), Gaps = 25/245 (10%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRS-----VKIFDVRNGGQILIADLRGHEGPVWQVAW 65 H I + +A+ + ++IF N +I A L H + ++ + Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-LPFHSLTITRLKF 618 Query: 66 AHPMYGNILASCSYDRKVIIW--KEENGTWEKTHEHSG-HDSSVNSVCWAPHDYGLILAC 122 + G L S DRK +W E+ T+E ++ H + WAP ++G + Sbjct: 619 SKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 676 Query: 123 GSSDGAISLLTYTGEGQWE-VKKINNAHTIGCNAVSWA-PAVVPGSLIDQPSGQKPNYIK 180 S D + + + E + V + + HT A+S + LI Y+ Sbjct: 677 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 736 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 + G + + +L + D + + W+ + S D Sbjct: 737 SYTLGKFELITQLNEDITPA------------DKITRLRWSHLKRNGKLFLGVGSSDLST 784 Query: 241 FIWTC 245 I++ Sbjct: 785 RIYSL 789 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 54/137 (39%), Gaps = 7/137 (5%) Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVA 219 P + Q + +KK + G I LW E L+ H V V Sbjct: 11 PEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 70 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 + P + S S+D V IW D S ++ + + ++ + V+ S ++++V Sbjct: 71 FVPDSD----FMVSASEDHHVKIWKFTDYS-HLQCIQTIQHYSKTI--VALSALPSLISV 123 Query: 280 SGGDNKVTLWKESVDGQ 296 D +++W++++ Sbjct: 124 GCADGTISIWRQNIQND 140 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 31/235 (13%), Positives = 64/235 (27%), Gaps = 52/235 (22%) Query: 11 SHEDMIHDAQM----DYYGTRLATCSSDRSVKIFDVRNGGQI------------------ 48 HED + L + S DR ++++ +R I Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 263 Query: 49 -------------LIADLRGHEGPVWQVAWAHPMYGNI-LASCSYDRKVIIW--KEENGT 92 A + GH+ + + W + L + + D +++W E +G Sbjct: 264 KFQIDDELRVGINFEALIMGHDDWISSLQW---HESRLQLLAATADTSLMVWEPDETSGI 320 Query: 93 WEKTHEH-----------SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 141 W + +G S W H+ G+ + + Sbjct: 321 WVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICD 380 Query: 142 VKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWRE 196 + + T ++W+P+ + + + G I W E Sbjct: 381 QRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHE 435 Score = 60.6 bits (145), Expect = 8e-10, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 83/227 (36%), Gaps = 31/227 (13%) Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD---GAISLLTYTGEGQWEVKK 144 + + W + + GH + + +P + AC S++ I + + E E+K Sbjct: 547 QRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST--ENWLEIKP 604 Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREE-EDGQWK 203 H++ + ++ K S D LW ED ++ Sbjct: 605 ALPFHSLTITRLKFS-----------------KDGKFLLSVCRDRKWALWERNMEDNTFE 647 Query: 204 EEQKLE-AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN 262 K E H+ + D WAP + + S+D V +W + + + K Sbjct: 648 LRFKNEKPHTRIIWDADWAP--LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHT 705 Query: 263 DVVWHVSWS---ITANILAVSGGDN-KVTLWKESVDGQWVCISDVNK 305 V +S I IL G +N ++ L+ ++ G++ I+ +N+ Sbjct: 706 KAVTAISIHDSMIREKILISVGLENGEIYLYSYTL-GKFELITQLNE 751 Score = 60.6 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 48/366 (13%), Positives = 90/366 (24%), Gaps = 84/366 (22%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR-------------GHE 57 H+D I Q +L ++D S+ +++ I + LR G Sbjct: 283 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 342 Query: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIW-KEENGTWEKTHEHSGHDSSVNSVC------ 110 G W W + + +W ++N ++ SG V + Sbjct: 343 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE 402 Query: 111 ------------------------------WAPHDYGLI---------------LACGSS 125 W I G Sbjct: 403 YLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGD 462 Query: 126 DGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASG 185 + + ++K + + + V L ++ N + G Sbjct: 463 EKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEG 522 Query: 186 GCDNLIKLWR-------------EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 G + + W E +KL H + + +P L IA Sbjct: 523 GNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKL----IA 578 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKL--LHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 S + V S W L + + + +S L D K LW+ Sbjct: 579 SACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE 638 Query: 291 ESVDGQ 296 +++ Sbjct: 639 RNMEDN 644 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 39/312 (12%), Positives = 84/312 (26%), Gaps = 41/312 (13%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV----RNGGQILIADLRG------HEGP 59 + + D G L S D++ ++F +G + IA H Sbjct: 386 SGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD 445 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 + V + S ++ + + G + G S D + Sbjct: 446 MICVE---TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEM---PDSATV 499 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP---------------AVVP 164 G S+ A + + E ++ P + Sbjct: 500 PVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLY 559 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIK---LWREEEDGQWKEEQKLEAHSDWVRDVAWA 221 G + K AS N ++ + + + + L HS + + ++ Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 619 Query: 222 PSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK-FNDVVWHVSWSIT--ANILA 278 + S +D + +W + K ++W W+ N+ Sbjct: 620 ----KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 675 Query: 279 VSGGDNKVTLWK 290 + D V +W+ Sbjct: 676 TASRDKTVKVWR 687 >4PSX-B nrPDB Length = 401 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 33/203 (16%) Query: 5 INTVDTSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 + T + H D+I+D + + T S D +KI DVR + D P + Sbjct: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQPFNTL 257 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 A++H N+LA+ D V ++ N E H SGH+ +VN++ ++ H G++++ G Sbjct: 258 AFSH-HSSNLLAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 Query: 124 SSDGAISLLTYTG-----------EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 S + + + +G E+ ++ H N P + Sbjct: 316 SDNRLM-MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI---------- 364 Query: 173 GQKPNYIKKFASGGCDNLIKLWR 195 AS +N++++W+ Sbjct: 365 ------PWLVASAEEENILQVWK 381 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 95/303 (31%), Gaps = 44/303 (14%) Query: 7 TVDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW 65 T HE+ I A+ +AT + + ++ G L + L+ H+ + +++ Sbjct: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG---LQSTLKFHKDNGYALSF 168 Query: 66 AHPMYGNILASCSYDRKVIIWKEENG--TWEKTHEHSG-HDSSVNSVCWAPHDYGLILAC 122 + + G +L S S D V +W+ +G + + H +N W + + Sbjct: 169 STLVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD-LFGT 226 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 S D + + N ++++ Sbjct: 227 VSEDSLLKINDVRANN---TTIDTVKCPQPFNTLAFSHHSS----------------NLL 267 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 A+ G D+ + L+ + + H D V ++ ++ + + S D R+ + Sbjct: 268 AAAGMDSYVYLYDLRN--MKEPLHHMSGHEDAVNNLEFSTHVDG---VVVSSGSDNRLMM 322 Query: 243 WTCDDASGNMW----------SPKLLHKFNDVVWHVSWSITAN-ILAVSGGDNKVTLWKE 291 W + V + ++A + +N + +WK Sbjct: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 Query: 292 SVD 294 S Sbjct: 383 SHS 385 Score = 51.4 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 37/197 (18%), Positives = 69/197 (35%), Gaps = 29/197 (14%) Query: 102 HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPA 161 H+ + + P D I+A + G L + + Q +K H A+S++ Sbjct: 117 HEEEITRARYMPQD-PNIVATINGQGTTFLYSRSEGLQSTLKF----HKDNGYALSFSTL 171 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEA--HSDWVRDVA 219 V + SG D+ + LW G + + HSD + D Sbjct: 172 V----------------KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAV 279 W + S+D + I + + + K FN + + ++N+LA Sbjct: 216 WH---NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFS---HHSSNLLAA 269 Query: 280 SGGDNKVTLWKESVDGQ 296 +G D+ V L+ + Sbjct: 270 AGMDSYVYLYDLRNMKE 286 >6J6H-n nrPDB Length = 455 Score = 102 bits (255), Expect = 1e-22, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 94/288 (32%), Gaps = 34/288 (11%) Query: 10 TSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 H + + G + + +D ++KI+D + + D +GH P+ + + Sbjct: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH-DYECLRDFQGHNKPIKALRFTED 217 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 S S+DR V IW E G + + + V S PH+ G S+ Sbjct: 218 CQS--FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSK 271 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 I + + + H A+ + P KF S D Sbjct: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFP-----------------DGSKFISSSED 314 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 +++W + + K+ HS +V + + + S D R++ ++ Sbjct: 315 KTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQN------YFCAQSMDNRIYSFSLKPK 368 Query: 249 SGNMWSPKLLHKFNDVVW--HVSWSITANILAVSGGDNKVTLWKESVD 294 K+ + + +++S + +++ W + Sbjct: 369 YKRHPK-KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS 415 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 66/208 (31%), Gaps = 28/208 (13%) Query: 99 HSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW 158 + GH ++ + P G ++ G +D I + + + +E + H A+ + Sbjct: 158 YPGHPEGTTALKFLPK-TGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHNKPIKALRF 214 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 + F S D +K+W E G+ K L + DV Sbjct: 215 -----------------TEDCQSFLSSSFDRSVKIWD-TETGKVKTRLHL---NSTPADV 253 Query: 219 AWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILA 278 P+ S S+ + D S N + + + + + Sbjct: 254 ESRPTNPHEFIVGLSNSK----ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 Query: 279 VSGGDNKVTLWKESVDGQWVCISDVNKG 306 S D V +W+ ++ ISD + Sbjct: 310 SSSEDKTVRIWENQINVPIKQISDTAQH 337 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 20/166 (12%), Positives = 47/166 (28%), Gaps = 46/166 (27%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNG-------------------------- 45 H I + G++ + S D++V+I++ + Sbjct: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYF 351 Query: 46 ------------------GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 + +GH + ++ A G + S ++ W Sbjct: 352 CAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 + G + + V W P + ++ G++ G I + Sbjct: 412 WNTSRLLNNIKIPG-NKPITQVDWHPQETSKVICSGAA-GKIYVCD 455 >4N14-A nrPDB Length = 314 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 94/276 (34%), Gaps = 34/276 (12%) Query: 16 IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 I G LA +S V+++DV+ Q + ++ H V ++W IL+ Sbjct: 66 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQ--QKRLRNMTSHSARVGSLSW----NSYILS 119 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL-TY 134 S S + SGH V + WAP G LA G +D +++ + Sbjct: 120 SGSRSGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPD--GRHLASGGNDNLVNVWPSA 176 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 GEG W + H AV+W P + + G D I++W Sbjct: 177 PGEGGWVPLQTFTQHQGAVKAVAWCP--------------WQSNVLATGGGTSDRHIRIW 222 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWS 254 ++AHS V + W+P S ++ IW M Sbjct: 223 NV---CSGACLSAVDAHSQ-VCSILWSPHYKELIS--GHGFAQNQLVIW----KYPTMAK 272 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 L V ++ S +A + D + LW+ Sbjct: 273 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Score = 97.6 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 86/241 (35%), Gaps = 38/241 (15%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 TSH + + Y L++ S + DVR +A L GH V + WA Sbjct: 102 TSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVAEHH-VATLSGHSQEVCGLRWAPD- 157 Query: 70 YGNILASCSYDRKVIIWKEENGT--WEKTHEHSGHDSSVNSVCWAPHDYGLILACGS-SD 126 G LAS D V +W G W + H +V +V W P ++ G SD Sbjct: 158 -GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSD 216 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 I + ++ ++ W+P + K+ SG Sbjct: 217 RHIRIWNVCSGACLSAVDAHSQ----VCSILWSP-----------------HYKELISGH 255 Query: 187 --CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 N + +W+ + +L+ H+ V + +P +T+AS + D + +W Sbjct: 256 GFAQNQLVIWKYPTMAK---VAELKGHTSRVLSLTMSPD----GATVASAAADETLRLWR 308 Query: 245 C 245 C Sbjct: 309 C 309 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 76/230 (33%), Gaps = 37/230 (16%) Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 V W+ GN+LA D V +W +G + + ++SV W G LA Sbjct: 27 VDWSS---GNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK--EGNYLAV 80 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G+S + L + + + +H+ ++SW ++ + + Sbjct: 81 GTSSAEVQLWDVQQQKR---LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE- 136 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 L HS V + WAP +AS D V + Sbjct: 137 --------------------HHVATLSGHSQEVCGLRWAPD----GRHLASGGNDNLVNV 172 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANILAVSGG--DNKVTLW 289 W G + + V V+W +N+LA GG D + +W Sbjct: 173 WPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 222 Score = 55.6 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 40/207 (19%), Positives = 74/207 (35%), Gaps = 35/207 (16%) Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGS 166 N V W+ G +LA D ++ L + + ++ ++ P S Sbjct: 25 NLVDWS---SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQ------------PGEYISS 68 Query: 167 LIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL 226 + G A G ++LW ++ + + + +HS V ++W Sbjct: 69 VAWIKEG------NYLAVGTSSAEVQLWDVQQQKRL---RNMTSHSARVGSLSWNS---- 115 Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 ++S S+ G + A + L + V + W+ LA G DN V Sbjct: 116 --YILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 170 Query: 287 TLW-KESVDGQWVCISDVNKGQGSVSA 312 +W +G WV + + QG+V A Sbjct: 171 NVWPSAPGEGGWVPLQTFTQHQGAVKA 197 >5UZ7-B nrPDB Length = 351 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 77/252 (30%), Gaps = 36/252 (14%) Query: 51 ADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVC 110 LRGH ++ + W +L S S D K+IIW T K H S V + Sbjct: 60 RTLRGHLAKIYAMHWGTD--SRLLVSASQDGKLIIWDSY--TTNKVHAIPLRSSWVMTCA 115 Query: 111 WAPHDYGLILACGSSDGAISLLTYTG-EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169 +AP G +ACG D S+ EG V + HT + + Sbjct: 116 YAP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF----------- 162 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTS 229 + + D LW E Q H+ V ++ AP L Sbjct: 163 -------LDDNQIVTSSGDTTCALWDIETGQQTTTFTG---HTGDVMSLSLAPDTRL--- 209 Query: 230 TIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 S + D +W + + + + + N A D L+ Sbjct: 210 -FVSGACDASAKLWDVREG----MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF 264 Query: 290 KESVDGQWVCIS 301 D + + S Sbjct: 265 DLRADQELMTYS 276 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 93/315 (29%), Gaps = 48/315 (15%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H I+ L + S D + I+D ++ LR V A+A Sbjct: 64 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR--SSWVMTCAYAP--S 119 Query: 71 GNILASCSYDRKVIIWKEEN--GTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 GN +A D I+ + G + E +GH ++ + + S D Sbjct: 120 GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF---LDDNQIVTSSGDTT 176 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 +L Q HT ++S AP + F SG CD Sbjct: 177 CALWDIETGQQ---TTTFTGHTGDVMSLSLAP-----------------DTRLFVSGACD 216 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 KLW E Q H + + + P+ + A+ S D ++ Sbjct: 217 ASAKLWDVREG---MCRQTFTGHESDINAICFFPN----GNAFATGSDDATCRLFDLRAD 269 Query: 249 SGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK----------ESVDGQWV 298 M + VS+S + +L D +W D + Sbjct: 270 QELM--TYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS 327 Query: 299 CISDVNKGQGSVSAS 313 C+ + G + S Sbjct: 328 CLGVTDDGMAVATGS 342 Score = 99.5 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 81/235 (34%), Gaps = 34/235 (14%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + + ++ T S D + ++D+ G Q H G V ++ A Sbjct: 151 AGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTG--HTGDVMSLSLAPDT 207 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 + S + D +W G +T +GH+S +N++C+ P+ G A GS D Sbjct: 208 --RLFVSGACDASAKLWDVREGMCRQT--FTGHESDINAICFFPN--GNAFATGSDDATC 261 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 L + + ++ G +VS++ + +G D Sbjct: 262 RLFDLRADQELMTYS-HDNIICGITSVSFS-----------------KSGRLLLAGYDDF 303 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 +W + + L H + V + + +A+ S D + IW Sbjct: 304 NCNVWDALKADR---AGVLAGHDNRVSCL----GVTDDGMAVATGSWDSFLKIWN 351 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 53/130 (40%), Gaps = 6/130 (4%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 + T HE I+ G AT S D + ++FD+R +++ + V Sbjct: 228 MCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV 287 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 +++ G +L + D +W ++ +GHD+ V+ + D G+ +A G Sbjct: 288 SFS--KSGRLLLAGYDDFNCNVWDAL--KADRAGVLAGHDNRVSCLGVT--DDGMAVATG 341 Query: 124 SSDGAISLLT 133 S D + + Sbjct: 342 SWDSFLKIWN 351 Score = 33.7 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 8/54 (14%), Positives = 19/54 (35%), Gaps = 1/54 (1%) Query: 244 TCDD-ASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 D M + + L ++ + W + +L + D K+ +W + Sbjct: 47 NIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNK 100 >5WLC-LO nrPDB Length = 923 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 52/330 (15%), Positives = 98/330 (29%), Gaps = 60/330 (18%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQ 62 V + V H I + T S D S KI+ V + + L A GH V Sbjct: 137 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 196 Query: 63 VAWAHPMYGNILASCSYDRKVIIW-----------------------KEENGTWEKTHEH 99 ++H + + S D V +W +W T +H Sbjct: 197 AFFSHDQ--EKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 254 Query: 100 --SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157 + + V V + P +LA G + G L + + + Sbjct: 255 FFYANQAKVKCVTFHPATR--LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS--- 309 Query: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 + + + + + L+ W+ E K + H D Sbjct: 310 -------VNQTGEWLAFGSSKLGQL-------LVYEWQSE-----SYILKQQGHFDSTNS 350 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 +A++P S + + S+DG++ +W + + V V ++ ++ Sbjct: 351 LAYSPD----GSRVVTASEDGKIKVWDITSG----FCLATFEEHTSSVTAVQFAKRGQVM 402 Query: 278 AVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 S D V W + + + Q Sbjct: 403 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQ 432 Score = 101 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 54/322 (16%), Positives = 108/322 (33%), Gaps = 53/322 (16%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D + G+R+ T S D +K++D+ +G +A H V V +A Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG--FCLATFEEHTSSVTAVQFA--KR 398 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG-AI 129 G ++ S S D V W +T + N + P G ++ GS D I Sbjct: 399 GQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQF-NCLAVDP--SGEVVCAGSLDNFDI 455 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + + ++ + H + +S++ AS D Sbjct: 456 HVWSVQTG---QLLDALSGHEGPVSCLSFSQENSV-----------------LASASWDK 495 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 I++W Q E + V A S+ +A + G++ I+ +DA Sbjct: 496 TIRIWSIFGRSQQVEPIE-------VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAK 548 Query: 250 --GNMWSPKLL--------------HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 GN+ K + + + + +S + G +N + L+ V Sbjct: 549 QVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYD--V 606 Query: 294 DGQWVCISDVNKGQGSVSASIT 315 + + + +++ ++ Sbjct: 607 PNEVLLKRFIVSRNMALNGTLE 628 Score = 61.4 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 48/366 (13%), Positives = 104/366 (28%), Gaps = 82/366 (22%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 T + H I ++ GT L + D + + + + + + V ++ Sbjct: 49 TFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK---EKCSAVKFS 105 Query: 67 HPMYGNILASCSYDRKVIIWKEEN-------GTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 G + A S R + IWK + + + H+GH + S+ W+ Sbjct: 106 PD--GRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS--QDSRF 160 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAH------------------------------ 149 + S D + + + E + N H Sbjct: 161 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 220 Query: 150 -------------------TIGCNAVSWA---PAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + SW + + A G Sbjct: 221 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 280 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD-GRVFIWTCD 246 +L+ + + Q+L + V V S+ +A S G++ ++ Sbjct: 281 SGEFRLYDLPD---FTLIQQLSMGQNPVNTV----SVNQTGEWLAFGSSKLGQLLVYEWQ 333 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 S + D +++S + + + D K+ +W + C++ + Sbjct: 334 SESYILKQ----QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG---FCLATFEEH 386 Query: 307 QGSVSA 312 SV+A Sbjct: 387 TSSVTA 392 Score = 44.4 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 48/150 (32%), Gaps = 24/150 (16%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ--VAWAH 67 + HE + + LA+ S D++++I+ + Q + V+ +A + Sbjct: 470 SGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPI------EVYSDVLALSM 523 Query: 68 PMYGNILASCSYDRKVIIWKEENGTW----------------EKTHEHSGHDSSVNSVCW 111 G +A + ++ I+ E+ + + S Sbjct: 524 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 583 Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWE 141 G+ + G ++ +I L E + Sbjct: 584 HYSFDGMAIVAGGNNNSICLYDVPNEVLLK 613 Score = 36.4 bits (82), Expect = 0.020, Method: Composition-based stats. Identities = 14/103 (13%), Positives = 35/103 (33%), Gaps = 10/103 (9%) Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN-----MWSPKLLHKFNDVVWHVSW 270 V ++P L +AS + IW D + + ++ + ++W Sbjct: 100 SAVKFSPDGRLFA--LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 154 Query: 271 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSAS 313 S + + + D +W + + + + N + V + Sbjct: 155 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 197 >3JB9-g nrPDB Length = 558 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 93/283 (32%), Gaps = 35/283 (12%) Query: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H I + G L + S D +KI++V + + L+ +GH P+ ++++ Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYH-DRSLLRTFQGHARPIRDLSFSQD- 321 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPH-DYGLILACGSSDGA 128 G S S+D+ + +W E G D N V + D G++D Sbjct: 322 -GRSFLSTSFDKTIKLWDTELGKC---LNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKR 377 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 I + + H G N++++ K+F + D Sbjct: 378 ILQFDIRSPDIVQA---YDHHLGGINSITF-----------------LENGKRFVTTSDD 417 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 + ++ W K + HS VA P+ +IA S D +++++ + Sbjct: 418 SSMRFWEYGTPVPIKFVADIAMHSMP--RVALRPN----GKSIACQSLDNCIYVYSAYEK 471 Query: 249 -SGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 N + + V +S + W Sbjct: 472 YRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWD 514 Score = 93.4 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 41/285 (14%), Positives = 88/285 (30%), Gaps = 39/285 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA-HPM 69 H I D G + S D+++K++D G + + V + P Sbjct: 308 GHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGK--CLNCFNS-DRLTNCVKFQVDPD 364 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 N + + D++++ + + + ++H H +NS+ + + G S D ++ Sbjct: 365 KPNEFLAGTADKRILQFDIRSPDIVQAYDH--HLGGINSITF--LENGKRFVTTSDDSSM 420 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 Y + H P K A DN Sbjct: 421 RFWEYGTPVPIKFVADIAMH-------------------SMPRVALRPNGKSIACQSLDN 461 Query: 190 LIKLWREEEDGQWKEEQKLEAH--SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD 247 I ++ E + +++ + + S + +V ++P + S G W Sbjct: 462 CIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPD----GRFVFSGDSSGNACFWDWKT 517 Query: 248 ASGNMWSPKLLHKFNDVVWHVSWSI--TANILAVSGGDNKVTLWK 290 L + V +++ T+ + S D + W Sbjct: 518 ----CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 80.6 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 34/242 (14%), Positives = 68/242 (28%), Gaps = 34/242 (14%) Query: 52 DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCW 111 +GH + + + P+ G++L S S D ++ IW+ + GH + + + Sbjct: 261 TWKGHTKGISCLRFF-PISGHLLLSGSMDNQIKIWEVYHDR-SLLRTFQGHARPIRDLSF 318 Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 + G S D I L N+ C P Sbjct: 319 S--QDGRSFLSTSFDKTIKLWDTELGKCLNC--FNSDRLTNCVKFQVDP----------- 363 Query: 172 SGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 + +F +G D I + Q + H + + + + Sbjct: 364 -----DKPNEFLAGTADKRILQFDIRSPD---IVQAYDHHLGGINSITFLEN----GKRF 411 Query: 232 ASCSQDGRVFIWTC-DDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + S D + W + +H V+ +A DN + ++ Sbjct: 412 VTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP----RVALRPNGKSIACQSLDNCIYVYS 467 Query: 291 ES 292 Sbjct: 468 AY 469 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 57/211 (27%), Gaps = 29/211 (13%) Query: 96 THEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNA 155 GH ++ + + P G +L GS D I + + + + H Sbjct: 259 IFTWKGHTKGISCLRFFP-ISGHLLLSGSMDNQIKIWEVYHDR--SLLRTFQGHARPIRD 315 Query: 156 VSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWV 215 +S++ + F S D IKLW E Sbjct: 316 LSFS-----------------QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDR----LT 354 Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITAN 275 V + P +A + D R+ + + + +++ Sbjct: 355 NCVKFQVDPDKPNEFLA-GTADKRILQFDIRSPD----IVQAYDHHLGGINSITFLENGK 409 Query: 276 ILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 + D+ + W+ ++D+ Sbjct: 410 RFVTTSDDSSMRFWEYGTPVPIKFVADIAMH 440 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 30/98 (30%), Gaps = 6/98 (6%) Query: 202 WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKF 261 K + H+ + + + P + + S S D ++ IW + Sbjct: 256 KKHIFTWKGHTKGISCLRFFP---ISGHLLLSGSMDNQIKIWEVYHDRS---LLRTFQGH 309 Query: 262 NDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVC 299 + +S+S + D + LW + C Sbjct: 310 ARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNC 347 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 15/34 (44%), Gaps = 2/34 (5%) Query: 10 TSHEDMIHDAQMDYYGT-RLATCS-SDRSVKIFD 41 +H + T ++AT S D S+K +D Sbjct: 525 PAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >5I2T-A nrPDB Length = 742 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 52/330 (15%), Positives = 98/330 (29%), Gaps = 60/330 (18%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQ 62 V + V H I + T S D S KI+ V + + L A GH V Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 221 Query: 63 VAWAHPMYGNILASCSYDRKVIIW-----------------------KEENGTWEKTHEH 99 ++H + + S D V +W +W T +H Sbjct: 222 AFFSHDQ--EKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 279 Query: 100 --SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157 + + V V + P +LA G + G L + + + Sbjct: 280 FFYANQAKVKCVTFHPATR--LLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVS--- 334 Query: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 + + + + + L+ W+ E K + H D Sbjct: 335 -------VNQTGEWLAFGSSKLGQL-------LVYEWQSE-----SYILKQQGHFDSTNS 375 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 +A++P S + + S+DG++ +W + + V V ++ ++ Sbjct: 376 LAYSPD----GSRVVTASEDGKIKVWDITSG----FCLATFEEHTSSVTAVQFAKRGQVM 427 Query: 278 AVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 S D V W + + + Q Sbjct: 428 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQ 457 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 54/322 (16%), Positives = 108/322 (33%), Gaps = 53/322 (16%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D + G+R+ T S D +K++D+ +G +A H V V +A Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG--FCLATFEEHTSSVTAVQFA--KR 423 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG-AI 129 G ++ S S D V W +T + N + P G ++ GS D I Sbjct: 424 GQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQF-NCLAVDP--SGEVVCAGSLDNFDI 480 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + + ++ + H + +S++ AS D Sbjct: 481 HVWSVQTG---QLLDALSGHEGPVSCLSFSQENSV-----------------LASASWDK 520 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 I++W Q E + V A S+ +A + G++ I+ +DA Sbjct: 521 TIRIWSIFGRSQQVEPIE-------VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAK 573 Query: 250 --GNMWSPKLL--------------HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 GN+ K + + + + +S + G +N + L+ V Sbjct: 574 QVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYD--V 631 Query: 294 DGQWVCISDVNKGQGSVSASIT 315 + + + +++ ++ Sbjct: 632 PNEVLLKRFIVSRNMALNGTLE 653 Score = 59.8 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 48/366 (13%), Positives = 104/366 (28%), Gaps = 82/366 (22%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 T + H I ++ GT L + D + + + + + + V ++ Sbjct: 74 TFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFK---EKCSAVKFS 130 Query: 67 HPMYGNILASCSYDRKVIIWKEEN-------GTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 G + A S R + IWK + + + H+GH + S+ W+ Sbjct: 131 PD--GRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWS--QDSRF 185 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAH------------------------------ 149 + S D + + + E + N H Sbjct: 186 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 245 Query: 150 -------------------TIGCNAVSWA---PAVVPGSLIDQPSGQKPNYIKKFASGGC 187 + + SW + + A G Sbjct: 246 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 305 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD-GRVFIWTCD 246 +L+ + + Q+L + V V S+ +A S G++ ++ Sbjct: 306 SGEFRLYDLPD---FTLIQQLSMGQNPVNTV----SVNQTGEWLAFGSSKLGQLLVYEWQ 358 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 S + D +++S + + + D K+ +W + C++ + Sbjct: 359 SESYILKQ----QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG---FCLATFEEH 411 Query: 307 QGSVSA 312 SV+A Sbjct: 412 TSSVTA 417 Score = 43.7 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 48/150 (32%), Gaps = 24/150 (16%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ--VAWAH 67 + HE + + LA+ S D++++I+ + Q + V+ +A + Sbjct: 495 SGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPI------EVYSDVLALSM 548 Query: 68 PMYGNILASCSYDRKVIIWKEENGTW----------------EKTHEHSGHDSSVNSVCW 111 G +A + ++ I+ E+ + + S Sbjct: 549 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 608 Query: 112 APHDYGLILACGSSDGAISLLTYTGEGQWE 141 G+ + G ++ +I L E + Sbjct: 609 HYSFDGMAIVAGGNNNSICLYDVPNEVLLK 638 Score = 35.6 bits (80), Expect = 0.031, Method: Composition-based stats. Identities = 14/103 (13%), Positives = 35/103 (33%), Gaps = 10/103 (9%) Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN-----MWSPKLLHKFNDVVWHVSW 270 V ++P L +AS + IW D + + ++ + ++W Sbjct: 125 SAVKFSPDGRLFA--LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 179 Query: 271 SITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSAS 313 S + + + D +W + + + + N + V + Sbjct: 180 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGA 222 >6GMH-W nrPDB Length = 305 Score = 99 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 109/315 (34%), Gaps = 44/315 (13%) Query: 11 SHEDMIHDAQMDYYGT----RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 +H+D I + T S D VK++ R+ L L GH+ V V + Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 H + I AS S D + +W ENG K+ + ++ ++P LA G+ Sbjct: 74 HTLP--IAASSSLDAHIRLWDLENGKQIKSIDAG--PVDAWTLAFSPD--SQYLATGTHV 127 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 G +++ + + +++++P K ASG Sbjct: 128 GKVNIFGVESGKKEYSLDTRGKFIL---SIAYSP-----------------DGKYLASGA 167 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D +I ++ K LE H+ +R + ++P + + S DG + I+ Sbjct: 168 IDGIINIFDI---ATGKLLHTLEGHAMPIRSLTFSPDS----QLLVTASDDGYIKIYDVQ 220 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306 A+ L V +V++ S D V +W G C+ Sbjct: 221 HAN----LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV---GTRTCVHTFFDH 273 Query: 307 QGSVSASITEGQQNE 321 Q V G ++ Sbjct: 274 QDQVWGVKYNGNGSK 288 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 25/92 (27%), Positives = 35/92 (38%), Gaps = 2/92 (2%) Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV 268 +AH D + VAW + + T+ + S D V +W D ++ L V V Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWS--LEGHQLGVVSV 70 Query: 269 SWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 S T I A S D + LW Q I Sbjct: 71 DISHTLPIAASSSLDAHIRLWDLENGKQIKSI 102 Score = 38.3 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 36/78 (46%), Gaps = 4/78 (5%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 + H + + T + SSD+SVK++DV G + + H+ VW V + Sbjct: 229 SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV--GTRTCVHTFFDHQDQVWGVKYN--G 284 Query: 70 YGNILASCSYDRKVIIWK 87 G+ + S D+++ I+ Sbjct: 285 NGSKIVSVGDDQEIHIYD 302 >4J0W-A nrPDB Length = 343 Score = 94.1 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 43/296 (14%), Positives = 97/296 (32%), Gaps = 51/296 (17%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR---------GHEGPVW 61 H+ I + + + + + D S+ + V +G ++ + GH V Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 +A + G LAS + ++IW+ ++ + + +GH +V+ + + + L Sbjct: 72 CMAISSD--GKYLASGDRSKLILIWEAQS--CQHLYTFTGHRDAVSGLAFRRGTHQ--LY 125 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 S D ++ + E + +A+S Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS--------------------RECC 165 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 +GG D +++W+ E+ Q H + + + + S + DG V Sbjct: 166 VTAGGRDGTVRVWKIPEESQLV----FYGHQGSIDCIHL-----INEEHMVSGADDGSVA 216 Query: 242 IWTCDDASGNMWS-----PKLLHKFNDVVW--HVSWSITANILAVSGGDNKVTLWK 290 +W + W V+ + +++A + V LW+ Sbjct: 217 LWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 97/303 (32%), Gaps = 49/303 (16%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H + + G LA+ + + I++ + + GH V +A+ Sbjct: 64 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQ--SCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 + L S S+DR V +W ++ GH +V ++ + + G DG + Sbjct: 122 HQ--LYSTSHDRSVKVWNVAENSY--VETLFGHQDAVAALDALSRE--CCVTAGGRDGTV 175 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 + E Q + H + + SG D Sbjct: 176 RVWKIPEESQL----VFYGHQGSIDCIHLINEEH------------------MVSGADDG 213 Query: 190 LIKLWREEEDGQWKEEQKLEAHSD--------WVRDVAWAPSIGLPTSTIASCSQDGRVF 241 + LW + +++ W+ VA L T +A+ S V Sbjct: 214 SVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVA----ALLNTDLVATGSHSSCVR 269 Query: 242 IWTCDD--ASGNMWSPKLLHKFNDVVWHVSWSITANILAVS-GGDNKV-TLWKESVDGQW 297 +W C + ++ L F + + +S + + L G ++++ W+ Sbjct: 270 LWQCGEGFRQLDLLCDIPLVGF---INSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNS 326 Query: 298 VCI 300 VCI Sbjct: 327 VCI 329 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 14/94 (14%), Positives = 29/94 (30%), Gaps = 11/94 (11%) Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHK---- 260 + L H + + P S I S ++D + W+ + P+ Sbjct: 7 IRVLRGHQLSITCLVVTPD----DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 62 Query: 261 ---FNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 + V ++ S LA + +W+ Sbjct: 63 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEA 96 >3ODT-A nrPDB Length = 313 Score = 92.6 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 91/279 (32%), Gaps = 51/279 (18%) Query: 17 HDAQMDYYGTRLATCSSDRSVK-IFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 + D L D + + G+ + L GH+G V +++ ++ Sbjct: 63 NSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF----QDGVVI 118 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNS---VCWAPHDYGLILACGSSDGAISLL 132 S S+D+ +WKE + + H++SV V ++ + S+D I L Sbjct: 119 SGSWDKTAKVWKEGS----LVYNLQAHNASVWDAKVVSFSENK----FLTASADKTIKLW 170 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + G D F S D LIK Sbjct: 171 QNDKVIKT----------------------FSGIHNDVVRHLAVVDDGHFISCSNDGLIK 208 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 L + E H +V + P+ I SC +D V IW+ + +G++ Sbjct: 209 LVDMHTGDVL---RTYEGHESFVYCIKLLPNGD-----IVSCGEDRTVRIWSKE--NGSL 258 Query: 253 WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 L + +W V +I+ DN V ++ + Sbjct: 259 KQVITLPAIS--IWSVDCMSNGDIIV-GSSDNLVRIFSQ 294 Score = 75.6 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 38/150 (25%), Positives = 62/150 (41%), Gaps = 11/150 (7%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 VI T H D++ + G + +CS+D +K+ D+ G ++ GHE V+ + Sbjct: 175 VIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGD--VLRTYEGHESFVYCI 231 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 + SC DR V IW +ENG+ ++ S+ SV G I+ G Sbjct: 232 KLLPNGD---IVSCGEDRTVRIWSKENGSLKQVITLPAI--SIWSVD--CMSNGDIIV-G 283 Query: 124 SSDGAISLLTYTGEGQWEVKKINNAHTIGC 153 SSD + + + +I GC Sbjct: 284 SSDNLVRIFSQEKSRWASEDEIKGELRSGC 313 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 37/198 (18%), Positives = 76/198 (38%), Gaps = 35/198 (17%) Query: 11 SHEDMIHDAQM-DYYGTRLATCSSDRSVKIFDVRNGGQILIADLRG-HEGPVWQVAWAHP 68 +H + DA++ + + T S+D+++K++ +I G H V +A Sbjct: 140 AHNASVWDAKVVSFSENKFLTASADKTIKLW----QNDKVIKTFSGIHNDVVRHLAV--- 192 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 + SCS D + + G +T+E GH+S V + P+ G I++CG D Sbjct: 193 VDDGHFISCSNDGLIKLVDMHTGDVLRTYE--GHESFVYCIKLLPN--GDIVSCG-EDRT 247 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 + + + +V + + +S G D Sbjct: 248 VRIWSKENGSLKQVITLPAISIWSVDCMS---------------------NGDIIVGSSD 286 Query: 189 NLIKLWREEEDGQWKEEQ 206 NL++++ +E+ E++ Sbjct: 287 NLVRIFSQEKSRWASEDE 304 Score = 32.9 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 34/135 (25%), Gaps = 10/135 (7%) Query: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217 + + K AS D ++LW +++ + + V Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVC- 66 Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 + +D + SG L V +S+ ++ Sbjct: 67 ------YDSEKELLLFGGKDTMINGVPLFATSGE-DPLYTLIGHQGNVCSLSFQ--DGVV 117 Query: 278 AVSGGDNKVTLWKES 292 D +WKE Sbjct: 118 ISGSWDKTAKVWKEG 132 >4A11-B nrPDB Length = 408 Score = 91.0 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 82/263 (31%), Gaps = 55/263 (20%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG-----------HDS 104 H G + + P+ G + S D ++++ EN + + + H Sbjct: 42 HGGGINTLDIE-PVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRY 100 Query: 105 SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 SV +V W PHD G + S D + + +V + +P Sbjct: 101 SVETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVF----NFEETVYSHHMSPVSTK 155 Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 L+ + + SG C L+ H + V+W+P Sbjct: 156 HCLVAVGTRGPKVQLCDLKSGSCS-----------------HILQGHRQEILAVSWSP-- 196 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH---------------KFNDVVWHVS 269 +A+ S D RV +W ASG L N V + Sbjct: 197 -RYDYILATASADSRVKLWDVRRASG---CLITLDQHNGKKSQAVESANTAHNGKVNGLC 252 Query: 270 WSITANILAVSGGDNKVTLWKES 292 ++ L G DN++ LW S Sbjct: 253 FTSDGLHLLTVGTDNRMRLWNSS 275 Score = 82.2 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 78/264 (29%), Gaps = 53/264 (20%) Query: 12 HEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRG-----------HEGP 59 H I+ ++ G + + SD + ++D+ N + + H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYG-L 118 V V W +P + S S+D+ + +W + +V S +P Sbjct: 102 VETVQW-YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF---EETVYSHHMSPVSTKHC 157 Query: 119 ILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 ++A G+ + L I H AVSW+P Y Sbjct: 158 LVAVGTRGPKVQLCDLKSGSC---SHILQGHRQEILAVSWSPR----------------Y 198 Query: 179 IKKFASGGCDNLIKLWREEEDGQW-------------KEEQKLEAHSDWVRDVAWAPSIG 225 A+ D+ +KLW E AH+ V + + Sbjct: 199 DYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD-- 256 Query: 226 LPTSTIASCSQDGRVFIWTCDDAS 249 + + D R+ +W + Sbjct: 257 --GLHLLTVGTDNRMRLWNSSNGE 278 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 81/289 (28%), Gaps = 82/289 (28%) Query: 12 HEDMIHDAQMDYYGT-RLATCSSDRSVKIFDVRNGGQI---------------------- 48 H + Q + T + S D+++K++D Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 Query: 49 --------------------LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKE 88 L+GH + V+W+ P Y ILA+ S D +V +W Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS-PRYDYILATASADSRVKLWDV 216 Query: 89 E------------NGTWEKTHEH--SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 NG + E + H+ VN +C+ GL L +D + L Sbjct: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD--GLHLLTVGTDNRMRLWNS 274 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 + V + CN S +F + I ++ Sbjct: 275 SNGENTLV-----NYGKVCN----------NSKKGLKFTVSCGCSSEFVFVPYGSTIAVY 319 Query: 195 REEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 Q L+ H V + + + S S+D + W Sbjct: 320 TVYSGEQ---ITMLKGHYKTVDCCVFQSN----FQELYSGSRDCNILAW 361 Score = 64.9 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 75/219 (34%), Gaps = 19/219 (8%) Query: 102 HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPA 161 H +N++ P + +L+ GS DG I L ++ C+ P Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGS-DGVIVLYDLENSS----RQSYYTCKAVCSIGRDHPD 96 Query: 162 VVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWA 221 V S+ + P+ F S D +K+W + + + V + Sbjct: 97 VHRYSV--ETVQWYPHDTGMFTSSSFDKTLKVWDTNT----LQTADVFNFEETVYSHHMS 150 Query: 222 PSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI-LAVS 280 P + +A ++ +V + S +L + VSWS + LA + Sbjct: 151 P-VSTKHCLVAVGTRGPKVQLCDLKSGS----CSHILQGHRQEILAVSWSPRYDYILATA 205 Query: 281 GGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQ 319 D++V LW C+ +++ G S ++ Sbjct: 206 SADSRVKLWDVRRASG--CLITLDQHNGKKSQAVESANT 242 Score = 50.6 bits (119), Expect = 8e-07, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 46/129 (35%), Gaps = 5/129 (3%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 + + +T+H ++ G L T +D +++++ NG L+ + + Sbjct: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 Query: 65 WA-HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 + + Y + ++ +G E+ GH +V+ + + L G Sbjct: 297 FTVSCGCSSEFVFVPYGSTIAVYTVYSG--EQITMLKGHYKTVDCCVFQSNFQE--LYSG 352 Query: 124 SSDGAISLL 132 S D I Sbjct: 353 SRDCNILAW 361 >4AEZ-A nrPDB Length = 401 Score = 91.0 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 95/294 (32%), Gaps = 35/294 (11%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 SV +T + + + G+ L+ + V I+DV Q + + GH+ V Sbjct: 124 SVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVE--SQTKLRTMAGHQARVGC 181 Query: 63 VAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 ++W ++L+S S + + GH S V + W GL LA Sbjct: 182 LSWNR----HVLSSGSRSGAIHHHDVRIAN-HQIGTLQGHSSEVCGLAWRSD--GLQLAS 234 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 G +D + + K H AV+W P + K + Sbjct: 235 GGNDNVVQIWDARSSI---PKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA 291 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 A+G N + + G HS + P D + I Sbjct: 292 ATGARVNTV------DAGSQVTSLIWSPHSKEIMSTHGFP--------------DNNLSI 331 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 W+ +S + + + V + + S IL+ + D + W+ DG Sbjct: 332 WSY--SSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRV-YDGD 382 Score = 84.1 bits (206), Expect = 7e-17, Method: Composition-based stats. Identities = 42/195 (21%), Positives = 71/195 (36%), Gaps = 26/195 (13%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + G +LA+ +D V+I+D R+ H V VAW P Sbjct: 215 GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKT--NHNAAVKAVAWC-PWQ 271 Query: 71 GNILASCS--YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 N+LA+ D+++ W G T + S V S+ W+PH ++ G D Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAG---SQVTSLIWSPHSKEIMSTHGFPDNN 328 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 +S+ +Y+ G + I AH + +P + ++ D Sbjct: 329 LSIWSYSSSGLTKQVDI-PAHDTRVLYSALSP-----------------DGRILSTAASD 370 Query: 189 NLIKLWREEEDGQWK 203 +K WR + K Sbjct: 371 ENLKFWRVYDGDHVK 385 Score = 47.1 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 56/168 (33%), Gaps = 12/168 (7%) Query: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFAS 184 D ++LL ++ V N + ++ S + S + + + Sbjct: 92 DDYYLNLLDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSV 151 Query: 185 GGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 G + L+ ++ E + + + H V ++W ++S S+ G + Sbjct: 152 GLGNGLVDIYDVESQTKL---RTMAGHQARVGCLSWN------RHVLSSGSRSGAIHHHD 202 Query: 245 CDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 A+ L + V ++W LA G DN V +W Sbjct: 203 VRIANH---QIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDAR 247 Score = 32.1 bits (71), Expect = 0.29, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 21/39 (53%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI 48 +H+ + + + G L+T +SD ++K + V +G + Sbjct: 346 PAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHV 384 >5A31-R nrPDB Length = 386 Score = 90.3 bits (222), Expect = 9e-19, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 97/289 (33%), Gaps = 40/289 (13%) Query: 6 NTVDTSH----EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 NT D H E+ G+ LA ++ V+I+DV + I L GH V Sbjct: 120 NTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDV--MKRKCIRTLSGHIDRVA 177 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 ++W + ++L S S D +++ H V + W D LA Sbjct: 178 CLSWNN----HVLTSGSRDHRILHRDVRMPDPF-FETIESHTQEVCGLKWNVADNK--LA 230 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 G +D + + T + + H A++W+P + Sbjct: 231 SGGNDNVVHVYEGTSKSPILT---FDEHKAAVKAMAWSPH--------------KRGVLA 273 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 G D +K+W + + + ++ W+ + ++ + + Sbjct: 274 TGGGTADRRLKIWNVNTSIKMSDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTL- 328 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 W C+ +M +L + V H++ S + GD + WK Sbjct: 329 -WDCN----SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 372 Score = 37.1 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 38/121 (31%), Gaps = 46/121 (38%) Query: 12 HEDMIHDAQMDYYGT-RLATCS--SDRSVKIF---------DVRNGGQIL---------- 49 H+ + + LAT +DR +KI+ D+ +G QI Sbjct: 255 HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNE 314 Query: 50 ----------------------IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 IA L+GH V + ++ G + S + D + WK Sbjct: 315 LVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSND--GTTVVSGAGDETLRYWK 372 Query: 88 E 88 Sbjct: 373 L 373 >3DWL-C nrPDB Length = 377 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 56/310 (18%), Positives = 109/310 (35%), Gaps = 23/310 (7%) Query: 20 QMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSY 79 + T T ++ V++++ G H+ V V WA N + +CS Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAP--KSNRIVTCSQ 75 Query: 80 DRKVIIWKEE-NGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 DR ++++ +GTW++T + + V W+P++ A GS IS+ + E Sbjct: 76 DRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDK--FAVGSGARVISVCYFEQEN 133 Query: 139 QWEV-KKINNAHTIGCNAVSWAPAVVP--GSLIDQPSGQKPNYIKKFASGGCDNLIKLWR 195 W V K + ++ W P V D+ + Y++ +W Sbjct: 134 DWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDV---DAKPEASVWG 190 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 + WV V ++PS + +A D V I + Sbjct: 191 SRLPFNTVCAEYPSG--GWVHAVGFSPS----GNALAYAGHDSSVTIAYPSAPEQPPRAL 244 Query: 256 KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS---- 311 + + + W+ + I+A + + L + + W D++ G S Sbjct: 245 ITVKLSQLPLRSLLWANESAIVAAGYNYSPILL--QGNESGWAHTRDLDAGTSKTSFTHT 302 Query: 312 ASITEGQQNE 321 + EG++ E Sbjct: 303 GNTGEGREEE 312 >3W15-A nrPDB Length = 368 Score = 89.1 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 110/329 (33%), Gaps = 78/329 (23%) Query: 13 EDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 +D + D + + ++ D ++++FD + IA + HE V+ W Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQ 120 Query: 72 NILASCSYDRKVIIW----------------------KEENGTWEKTHEHSGHDSS---V 106 N L S S+D + IW N K +G + V Sbjct: 121 NFL-SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 107 NSVCWAPHDYGLILACGSSDGA----ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 ++PHD L+L+C + A I L + + + V A + C+ + P V Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA--LTCDFNKYRPYV 237 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR----EEEDGQWK----EEQKLEAHSDW 214 V A+GG DN I++W + GQ + AH Sbjct: 238 V-------------------ATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLA 278 Query: 215 VRDVAWAPSIGLPTSTIASCSQDGRVFIW------------TCDDASGNMWSPKLLHKFN 262 +R V W+P + S S D IW + S + + Sbjct: 279 IRKVTWSPHHSN---ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 335 Query: 263 DVVWHVSWSITAN--ILAVSGGDNKVTLW 289 + V+ WS+ +A + D + +W Sbjct: 336 EFVFGADWSLWGKPGYVASTAWDGNLFVW 364 Score = 74.9 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 83/279 (29%), Gaps = 64/279 (22%) Query: 12 HEDMIHDAQMDYYGTR-LATCSSDRSVKIF----------------------DVRNGGQI 48 HE + + + + S D S+KI+ D N + Sbjct: 105 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 164 Query: 49 LIADLRGHEGPVWQV--AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSV 106 G V A P N++ SCS + ++ + + + H Sbjct: 165 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 224 Query: 107 NSVCWAPHDYGLILACGSSDGAISLLTYT--------GEGQWEVKKINNAHTIGCNAVSW 158 C ++A G D AI + + +I NAH + V+W Sbjct: 225 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTW 284 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQK----------- 207 +P S D ++WR+ + KE K Sbjct: 285 SPHHS----------------NILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 328 Query: 208 --LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 HS++V W+ + +AS + DG +F+W Sbjct: 329 FNFTQHSEFVFGADWS--LWGKPGYVASTAWDGNLFVWN 365 Score = 62.2 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 33/264 (12%), Positives = 72/264 (27%), Gaps = 54/264 (20%) Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 ++ +AW +L + D + ++ H+ V S W + Sbjct: 65 LFDLAWNESHENQVLVAQG-DGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNF 122 Query: 120 LACGSSDGAISLLTYTGEGQWEVKK------------------------INNAHTIGCNA 155 L+ S DG+I + + + + + Sbjct: 123 LSS-SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 156 VSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWV 215 ++P L + + + SG N + E + +V Sbjct: 182 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC----DFNKYRPYV 237 Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-------KLLHKFNDVVWHV 268 +A+ D + IW + N ++ + + V Sbjct: 238 ---------------VATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKV 282 Query: 269 SWSIT-ANILAVSGGDNKVTLWKE 291 +WS +NIL + D +W++ Sbjct: 283 TWSPHHSNILMSASYDMTCRIWRD 306 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 38/100 (38%), Gaps = 15/100 (15%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLA-TCSSDRSVKIF-DVRNGG-------------Q 47 S IN + +H I + + + + S D + +I+ D+ N G + Sbjct: 266 SCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATK 325 Query: 48 ILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 I + H V+ W+ +AS ++D + +W Sbjct: 326 GSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >5OQL-L nrPDB Length = 557 Score = 88.4 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 87/274 (31%), Gaps = 43/274 (15%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ-ILIADLRGHEGPVWQVAWAHPMYG 71 + H ++ G L +++FDV G + +++ H+ PVW W+ Sbjct: 99 DSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTEL- 157 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP-HDYGLILACGSSDGAIS 130 L SCS D+ V +W + + +GH V + P +L GS D + Sbjct: 158 TTLMSCSDDKTVRLWDLPSNDPTRL--FTGHTDYVRCGAFMPGSANSNLLVSGSYDETVR 215 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + G + + P+ A+ G N Sbjct: 216 VWDARAPGGAVMTFKHADPIEDV-------------------LPLPSGTTLLAASG--NA 254 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 I + K + + H V + S+ + S S DG V ++ Sbjct: 255 ISVLDLVAA---KPLRLITNHQKTVTSL----SLASQGRRVVSGSLDGHVKVFETTS--- 304 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 W+ K+ + +S I A + D+ Sbjct: 305 --WNVVAGAKYPSPILSLSV-----ITAGASHDD 331 Score = 81.8 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 84/258 (32%), Gaps = 41/258 (15%) Query: 37 VKIFDVRNGGQILIA---DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT- 92 V+IF +R + D H G + G +L + ++ ++ GT Sbjct: 81 VEIFSIRKREPLKTIGRFDSEAHCGEIR-------PDGRVLVAGEDTGRMQVFDVGQGTR 133 Query: 93 WEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIG 152 H V W+P + +++C S D + L + ++ HT Sbjct: 134 AVILKTWHIHKQPVWVTKWSPTELTTLMSC-SDDKTVRLWDLPSN---DPTRLFTGHTDY 189 Query: 153 CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHS 212 ++ P +L SG D +++W G K H+ Sbjct: 190 VRCGAFMPGSANSNL--------------LVSGSYDETVRVWDARAPGGAVMTFK---HA 232 Query: 213 DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI 272 D + DV PS +T+ + S + + + A +L+ V +S + Sbjct: 233 DPIEDVLPLPS----GTTLLAASGNA-ISVLDLVAAKP----LRLITNHQKTVTSLSLAS 283 Query: 273 TANILAVSGGDNKVTLWK 290 + D V +++ Sbjct: 284 QGRRVVSGSLDGHVKVFE 301 Score = 64.5 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 46/140 (32%), Gaps = 11/140 (7%) Query: 160 PAVVPGSLIDQPSGQKPNYIKKFASGGCDN-LIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 P G + + + G D ++++ + + + H V Sbjct: 91 PLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVT 150 Query: 219 AWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSW---SITAN 275 W+P+ +T+ SCS D V +W +L D V ++ S +N Sbjct: 151 KWSPT---ELTTLMSCSDDKTVRLWDLPSNDP----TRLFTGHTDYVRCGAFMPGSANSN 203 Query: 276 ILAVSGGDNKVTLWKESVDG 295 +L D V +W G Sbjct: 204 LLVSGSYDETVRVWDARAPG 223 Score = 35.6 bits (80), Expect = 0.027, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 31/88 (35%), Gaps = 6/88 (6%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + T+H+ + + G R+ + S D VK+F+ + + A P+ ++ Sbjct: 268 LITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKY---PSPILSLSVIT 324 Query: 68 ---PMYGNILASCSYDRKVIIWKEENGT 92 LA + I +G Sbjct: 325 AGASHDDRHLAVGMQSGVLSIRTRLSGP 352 >4BH6-A nrPDB Length = 308 Score = 88.4 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 97/289 (33%), Gaps = 40/289 (13%) Query: 6 NTVDTSH----EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 NT D H E+ G+ LA ++ V+I+DV + I L GH V Sbjct: 51 NTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDV--MKRKCIRTLSGHIDRVA 108 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 ++W + ++L S S D +++ H V + W D LA Sbjct: 109 CLSWNN----HVLTSGSRDHRILHRDVRMPDPF-FETIESHTQEVCGLKWNVADNK--LA 161 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 G +D + + T + + H A++W+P + Sbjct: 162 SGGNDNVVHVYEGTSKSPILT---FDEHKAAVKAMAWSPH--------------KRGVLA 204 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF 241 G D +K+W + + + ++ W+ + ++ + + Sbjct: 205 TGGGTADRRLKIWNVNTSIKMSDIDS----GSQICNMVWSKNTNELVTSHGYSKYNLTL- 259 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 W C+ +M +L + V H++ S + GD + WK Sbjct: 260 -WDCN----SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 303 Score = 36.0 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 38/121 (31%), Gaps = 46/121 (38%) Query: 12 HEDMIHDAQMDYYGT-RLATCS--SDRSVKIF---------DVRNGGQIL---------- 49 H+ + + LAT +DR +KI+ D+ +G QI Sbjct: 186 HKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNE 245 Query: 50 ----------------------IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 IA L+GH V + ++ G + S + D + WK Sbjct: 246 LVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSND--GTTVVSGAGDETLRYWK 303 Query: 88 E 88 Sbjct: 304 L 304 >4OWR-A nrPDB Length = 339 Score = 87.6 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 47/315 (14%), Positives = 95/315 (30%), Gaps = 47/315 (14%) Query: 7 TVDTSHEDMIHDAQMDYY---GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 V +S +D I G L S V+ ++V++ GQ + + H GPV V Sbjct: 4 EVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDV 63 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 W+ G+ + + S D+ +W + + + HD+ V ++ W + G Sbjct: 64 CWSDD--GSKVFTASCDKTAKMWDLSSNQAIQIAQ---HDAPVKTIHWIKAPNYSCVMTG 118 Query: 124 SSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA 183 S D + V ++ A Sbjct: 119 SWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMA-----------------------V 155 Query: 184 SGGCDNLIKLWREEED-GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 + + +++ E +++ + H R VA + A S +GRV I Sbjct: 156 VATAERGLIVYQLENQPSEFRRIESPLKHQH--RCVAIFKDKQNKPTGFALGSIEGRVAI 213 Query: 243 WTCDDASGNMWSPKLLHKFNDV------------VWHVSWSITANILAVSGGDNKVTLWK 290 + + V +++ LA G D + + W Sbjct: 214 HYINPPNPA-KDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWD 272 Query: 291 ESVDGQWVCISDVNK 305 + + +++ Sbjct: 273 KDARTKLKTSEQLDQ 287 >5WLC-LU nrPDB Length = 489 Score = 86.8 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 94/302 (31%), Gaps = 51/302 (16%) Query: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H D ++ +Y +LAT S+D +K +++ + + H G V + P Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMST--REEFVSFKAHYGLVTGLCVTQPR 122 Query: 70 Y---------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 + N + SCS D+ V +W S+N ++ + Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLW------------------SINVDDYSNKNSSDND 164 Query: 121 ACGSSDGAISLLTYTG---------EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP 171 + + +G I E H N + + G+ Sbjct: 165 SVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITS 224 Query: 172 SGQKPNYIKKFASGGCDNLIKLWREEEDG-QWKEEQKLEAHSDWVRDVAWAPSIGLPTST 230 N AS G DN I L+ + K Q + + W P + Sbjct: 225 LKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRT-----NAICWNP---MEAFN 276 Query: 231 IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + ++D + + + S S + V V +S T + + D + ++K Sbjct: 277 FVTANEDHNAYYYDMRNLS---RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYK 333 Query: 291 ES 292 + Sbjct: 334 TN 335 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 91/286 (31%), Gaps = 55/286 (19%) Query: 28 LATCSSDRSVKIF---------------DVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 + +CS D++VK++ D + LI G E + +H Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGID-SHRENST 193 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 A+ K+ +W + + S ++ S+ + ++ ++ + GS D +I L Sbjct: 194 F-ATGG--AKIHLWDVN--RLKPVSDLSWGADNITSLKFNQNETDILASTGS-DNSIVLY 247 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 + T+ NA+ W P F + D+ Sbjct: 248 DLRTNSPTQKIV----QTMRTNAICWNPMEAFN----------------FVTANEDHNAY 287 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 + + + H V DV ++P+ I + S D + I+ + Sbjct: 288 YYDMRNLSR--SLNVFKDHVSAVMDVDFSPT----GDEIVTGSYDKSIRIYKTNHGHSRE 341 Query: 253 WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 + V+ V +S+ + + D V LW+ W Sbjct: 342 IYHTKRMQH---VFQVKYSMDSKYIISGSDDGNVRLWR---SKAWE 381 Score = 80.6 bits (197), Expect = 7e-16, Method: Composition-based stats. Identities = 36/187 (19%), Positives = 69/187 (36%), Gaps = 8/187 (4%) Query: 17 HDAQMDYYGTR-LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILA 75 + + T + D + +D+RN + L + H V V ++ G+ + Sbjct: 265 NAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLN-VFKDHVSAVMDVDFSP--TGDEIV 321 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 + SYD+ + I+K +G + + H+ V V ++ D I+ GS DG + L Sbjct: 322 TGSYDKSIRIYKTNHGHSREIY-HTKRMQHVFQVKYS-MDSKYII-SGSDDGNVRLWRSK 378 Query: 136 GEGQWEVKKINNAHTIGCN-AVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLW 194 + VK + + + + +P P IKK L + Sbjct: 379 AWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIK 438 Query: 195 REEEDGQ 201 R E + + Sbjct: 439 RREANER 445 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 35/81 (43%), Gaps = 5/81 (6%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNG-GQILIADLRGHEGPVWQVAWAHPM 69 H + D G + T S D+S++I+ +G + + R V+QV ++ M Sbjct: 303 DHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKR--MQHVFQVKYS--M 358 Query: 70 YGNILASCSYDRKVIIWKEEN 90 + S S D V +W+ + Sbjct: 359 DSKYIISGSDDGNVRLWRSKA 379 Score = 37.1 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 29/97 (29%), Gaps = 18/97 (18%) Query: 210 AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHV- 268 H D V +A + +A+ S DG + W + +V + Sbjct: 65 GHRDGVYAIA---KNYGSLNKLATGSADGVIKYWNMSTREEFV----SFKAHYGLVTGLC 117 Query: 269 ----SWS------ITANILAVSGGDNKVTLWKESVDG 295 + + N + D V LW +VD Sbjct: 118 VTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDD 154 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 6/53 (11%), Positives = 17/53 (32%), Gaps = 9/53 (16%) Query: 11 SHEDMIHD---------AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR 54 H I+ + + + S D +V+++ + + + R Sbjct: 337 GHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTR 389 >5N4A-A nrPDB Length = 771 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 100/292 (34%), Gaps = 47/292 (16%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRG-----HEG 58 V + H ++ + + TCS D+++ +++ + ++ L H Sbjct: 5 VKQSSANVHSELTAAVGWNVWNELF-TCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWY 63 Query: 59 PVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGL 118 PV ++ A D V I G EK+ E GH + S+ W+ G Sbjct: 64 PVSS-KKTQAGGTDVFAVACTDGSVKI-LSRTGRVEKSIE--GHKGACISLRWS--YDGT 117 Query: 119 ILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 LA DG++ + + G ++ ++ WA Sbjct: 118 ALATAGEDGSVKIWSRNGM----LRSTLAQADSPVYSIVWAY---------------DCD 158 Query: 179 IKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG 238 + +G + + + + + +AH V V W+P I + +D Sbjct: 159 QLCYCTGS---NVVIKSLSSNAK---QNAWKAHDGVVLKVDWSP----INHLIITGGEDC 208 Query: 239 RVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + +W D ++ L F+ V V+W+ + + AV G N + L Sbjct: 209 KYKVW--DSFGRLLFQSGL---FDYPVTSVAWAPSGELFAVGGF-NTLQLCD 254 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 37/121 (30%), Gaps = 14/121 (11%) Query: 177 NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTS-----TI 231 N + + D I W + EQK+ + D+ W P T Sbjct: 23 NVWNELFTCSDDQTIHKWNMLGE----PEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVF 78 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 A DG V I + K + + WS LA +G D V +W Sbjct: 79 AVACTDGSVKILSRTG-----RVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSR 133 Query: 292 S 292 + Sbjct: 134 N 134 >3JZG-A nrPDB Length = 402 Score = 85.3 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 92/305 (30%), Gaps = 27/305 (8%) Query: 8 VDTSHEDMIHDAQMDYYGT----RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 VD ++ + Y LA S ++I + I GH + ++ Sbjct: 100 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT--MQCIKHYVGHGNAINEL 157 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTH-EHSGHDSSVNSVCWAPHDYGLILAC 122 + HP N+L S S D + +W + T GH V S + G + Sbjct: 158 KF-HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY--DLLGEKIMS 214 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPA--VVPGSLIDQPSGQKPNYIK 180 D ++ L + K + + + P + ++ Sbjct: 215 CGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVR 274 Query: 181 ----KFASGGCDNLIKLWREEEDGQWK-------EEQKLEAHSDWVRDVAWAP--SIGLP 227 S C+N I W+ + + D+ + W S+ Sbjct: 275 WLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFW 334 Query: 228 TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFN--DVVWHVSWSITANILAVSGGDNK 285 +A +Q G++++W + + L + S+S ++IL D Sbjct: 335 QKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS 394 Query: 286 VTLWK 290 + W Sbjct: 395 IWRWD 399 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 32/89 (35%), Gaps = 4/89 (4%) Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFND 263 + H + + ++ + P + + S S+D + +W + + D Sbjct: 143 CIKHYVGHGNAINELKFHP---RDPNLLLSVSKDHALRLWNIQT-DTLVAIFGGVEGHRD 198 Query: 264 VVWHVSWSITANILAVSGGDNKVTLWKES 292 V + + + G D+ + LW+ + Sbjct: 199 EVLSADYDLLGEKIMSCGMDHSLKLWRIN 227 Score = 35.2 bits (79), Expect = 0.037, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 25/94 (26%), Gaps = 5/94 (5%) Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI-TANI 276 AW +A G + I M K + + + + N+ Sbjct: 111 CAWTYDSNTSHPLLAVAGSRGIIRIINPIT----MQCIKHYVGHGNAINELKFHPRDPNL 166 Query: 277 LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 L D+ + LW D V + V Sbjct: 167 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEV 200 >5WLC-LJ nrPDB Length = 513 Score = 84.9 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 96/264 (36%), Gaps = 33/264 (12%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 +D+++ A G L + V ++D N IL+ + P V H Sbjct: 81 KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILL-SINASTHP-THVTKFHTQDNK 138 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ILA+ S DR +W N E E +G V ++ + P ++A GS DG I L Sbjct: 139 ILATASDDRVTRLWDISNAY-EPQLELTGATDYVRTLSFIPA-APHLVATGSYDGLIRLY 196 Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 G + +N+ + N ++ +P + S G +N K Sbjct: 197 DTRSSGSTPIYSLNHDQPVE-NVIAVSPT-------------------QIVSCGGNN-FK 235 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP-TSTIASCSQDGRVFIWTCDDASGN 251 +W + + E + V + + + P S + + S DG V ++ D Sbjct: 236 VWDLTSNKKLYERGNF---NKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDN--- 289 Query: 252 MWSPKLLHKFNDVVWHVSWSITAN 275 + K KF+ V + S + Sbjct: 290 -FQVKFGWKFSGPVLSCAVSPSTA 312 Score = 44.1 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 26/193 (13%), Positives = 52/193 (26%), Gaps = 31/193 (16%) Query: 104 SSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 +SV + + P S+ + + + +V K + + S+ Sbjct: 40 NSVTHISFNPQHPHDFAVTSST--RVQIFSSRTR---QVIKTFSRFKDVVYSASFR---- 90 Query: 164 PGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 + K +G L+ ++ H V Sbjct: 91 -------------SDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKF----- 132 Query: 224 IGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSGG 282 +A+ S D +W +A L D V +S+ A ++A Sbjct: 133 HTQDNKILATASDDRVTRLWDISNAYEPQLE---LTGATDYVRTLSFIPAAPHLVATGSY 189 Query: 283 DNKVTLWKESVDG 295 D + L+ G Sbjct: 190 DGLIRLYDTRSSG 202 >5OQL-X nrPDB Length = 630 Score = 84.5 bits (207), Expect = 5e-17, Method: Composition-based stats. Identities = 41/270 (15%), Positives = 79/270 (29%), Gaps = 30/270 (11%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + G + T +D+ + +++ + I H V +A+ Sbjct: 244 GHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLK--PIKAFTQHRDAVTGLAFRRGT- 300 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 N L SCS DR V +W + GH + + + ++ G+ D Sbjct: 301 -NQLYSCSKDRTVKVWSLD--ELAYVETLFGHQDEILDIDALGQER--CVSVGARDRTAR 355 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS--GQKPNYIKKFASGGCD 188 E Q + + P + P S + S F +G + Sbjct: 356 YWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDN 415 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVR------------DVAWAPSIGLPTST------ 230 + LW + + ++ + AP T+ Sbjct: 416 GDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYS 475 Query: 231 --IASCSQDGRVFIWTCDDASGNMWSPKLL 258 I S S DG + +W + + + +L Sbjct: 476 DLIFSGSWDGCIRVWRLSEDKRKLEAVGIL 505 Score = 72.2 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 73/229 (31%), Gaps = 35/229 (15%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T H D + +L +CS DR+VK++ + + L GH+ + + Sbjct: 285 TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLD--ELAYVETLFGHQDEILDID--ALG 340 Query: 70 YGNILASCSYDRKVIIWKEE-------------NGTWEKTHEHS--------GHDSSVNS 108 ++ + DR WK + K H+ H+ S++ Sbjct: 341 QERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDR 400 Query: 109 VCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 V + GS +G ++L + + V + ++ +P I Sbjct: 401 VA---MIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSI 457 Query: 169 DQPSGQKP-------NYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEA 210 + Y SG D I++WR ED + E + Sbjct: 458 IPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILG 506 Score = 61.8 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 44/126 (34%), Gaps = 11/126 (8%) Query: 165 GSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSI 224 G L + K +GG D + ++ K + H D V +A+ Sbjct: 244 GHLKAPLVVKASQDGKFVVTGGADKRLVVYN---AADLKPIKAFTQHRDAVTGLAF---- 296 Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDN 284 T+ + SCS+D V +W+ D + + L D + + ++V D Sbjct: 297 RRGTNQLYSCSKDRTVKVWSLD----ELAYVETLFGHQDEILDIDALGQERCVSVGARDR 352 Query: 285 KVTLWK 290 WK Sbjct: 353 TARYWK 358 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 15/119 (12%), Positives = 36/119 (30%), Gaps = 11/119 (9%) Query: 192 KLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGN 251 ++ + D + ++ + H V + + D R+ ++ D Sbjct: 226 RICFAKADARKANDKTYQGHLKAPLVVK----ASQDGKFVVTGGADKRLVVYNAADLKP- 280 Query: 252 MWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 K + D V +++ N L D V +W + + + Q + Sbjct: 281 ---IKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSL---DELAYVETLFGHQDEI 333 >4U1E-I nrPDB Length = 347 Score = 84.1 bits (206), Expect = 7e-17, Method: Composition-based stats. Identities = 46/278 (16%), Positives = 96/278 (34%), Gaps = 32/278 (11%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 T HE + + + G L +CS D S ++ NG + + L GH G +W + Sbjct: 7 TGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER--LGTLDGHTGTIWSIDV--DC 62 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP--HDYGLILACGSSDG 127 + + S D + +W NG T + V V ++P + + IL D Sbjct: 63 FTKYCVTGSADYSIKLWDVSNGQCVATWKSPV---PVKRVEFSPCGNYFLAIL-----DN 114 Query: 128 AISLLTYTGEGQWEVKKINNAHTIG-CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 + +E+++ + H + + + L K +G Sbjct: 115 VMK--NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGH 172 Query: 187 CDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 D I + + ++ + L H + D+ ++P + + + S+D F+ Sbjct: 173 KDGKISKYDVSNNYEYVDSIDL--HEKSISDMQFSPDL----TYFITSSRDTNSFLVDVS 226 Query: 247 DASGNMWSPKLLHKFND--VVWHVSWSITANILAVSGG 282 ++L K+ + + + + GG Sbjct: 227 T-------LQVLKKYETDCPLNTAVITPLKEFIILGGG 257 Score = 57.9 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 74/228 (32%), Gaps = 38/228 (16%) Query: 94 EKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGC 153 K + +GH+ + V + + G +L S D + S+ + G Sbjct: 1 MKAIKLTGHERPLTQVKY--NKEGDLLFSCSKDSSASVWYSLNGERLGTLD-------GH 51 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 W+ + K +G D IKLW +GQ K Sbjct: 52 TGTIWS-------------IDVDCFTKYCVTGSADYSIKLWDV-SNGQCVATWKSPV--- 94 Query: 214 WVRDVAWAPSIGLPTSTIASCSQD-GRVFIWTCDDASGNMWSPKL---------LHKFND 263 V+ V ++P + + + ++ G + I+ + S K+ H+ D Sbjct: 95 PVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLD 154 Query: 264 VVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311 WS + D K++ K V + + ++ + S+S Sbjct: 155 AATVAGWSTKGKYIIAGHKDGKIS--KYDVSNNYEYVDSIDLHEKSIS 200 Score = 31.3 bits (69), Expect = 0.51, Method: Composition-based stats. Identities = 5/33 (15%), Positives = 12/33 (36%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR 43 H ++ + GT A+ D +++ Sbjct: 291 GHFGPLNTVAISPQGTSYASGGEDGFIRLHHFE 323 >6ELZ-p nrPDB Length = 460 Score = 82.6 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 59/364 (16%), Positives = 101/364 (27%), Gaps = 99/364 (27%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 S+ED + + + + S D V+ +D+ Q GH GP+ V + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQ---KQYSGHSGPIRAVKYISN-- 155 Query: 71 GNILASCSYDRKVIIWKEENGTWEKT---------------------HEHSGHDSSVNSV 109 L S DR + +WK +N + T GH + V S+ Sbjct: 156 -TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSI 214 Query: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK----KINNAHTIGCNAVSWAPAVVPG 165 + + + S D +I + + V N + I A + Sbjct: 215 DVSDNSR---ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKD 271 Query: 166 SLIDQPSGQKPNYIKKFA---------------SGGCDNLIKLWREEED----------- 199 I + + S D+ IK W Sbjct: 272 GTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYS 331 Query: 200 -------------------------------GQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 +Q+L H ++V + P Sbjct: 332 LLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPE---NE 388 Query: 229 STIASCSQDGRVFIWTCDDASGNMWSPK----LLHKFNDVVWHVSWSITANILAVSGGDN 284 + S S DG V +W S + + ND V+ V W+ I+ +G D Sbjct: 389 YILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGII-SAGQDK 447 Query: 285 KVTL 288 K+ + Sbjct: 448 KIQI 451 Score = 51.4 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 23/155 (14%), Positives = 47/155 (30%), Gaps = 29/155 (18%) Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 + + S + K SG D +++ W + Q ++ HS +R V Sbjct: 95 SYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQ----KQYSGHSGPIRAV 150 Query: 219 AWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPK-------------------LLH 259 + + + + S D + +W + + S + +L Sbjct: 151 KYISN-----TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILE 205 Query: 260 KFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 V + S + IL + DN + W Sbjct: 206 GHKAPVVSIDVSDNSRIL-SASYDNSIGFWSTIYK 239 Score = 44.1 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 34/89 (38%), Gaps = 10/89 (11%) Query: 4 VINTVDTSHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIAD------LRGH 56 V H++ + L + S D +VK++DVR+ + +G Sbjct: 366 VTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGV 425 Query: 57 EGPVWQVAWAHPMYGNILASCSYDRKVII 85 V+ V WA + + S D+K+ I Sbjct: 426 NDKVFAVKWAEKVG---IISAGQDKKIQI 451 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 31/84 (36%), Gaps = 10/84 (11%) Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS 271 DWV + +G + I S S DG V W +S + + V + Sbjct: 103 EDWVSSL----DVGDGSKHIISGSYDGIVRTWDLSGNVQKQYS-----GHSGPIRAVKY- 152 Query: 272 ITANILAVSGGDNKVTLWKESVDG 295 I+ L +G D + LWK D Sbjct: 153 ISNTRLVSAGNDRTLRLWKTKNDD 176 >6E29-D nrPDB Length = 345 Score = 81.8 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 53/319 (16%), Positives = 105/319 (32%), Gaps = 29/319 (9%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 + NT+ + H + + G LA+ D +V I+D+ G + LRGH + + Sbjct: 19 ITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMG--VARKLRGHSKNITSL 73 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 +W+ G L S KVI+W ++G + V P ++ A Sbjct: 74 SWSR--CGRYLLSACQGWKVILWDLQDGKRYREVRFRA---PVYGAELHPWNHHQFAAAL 128 Query: 124 SSDG-AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 D + +T E ++ + + + + + + Sbjct: 129 FEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHL 188 Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 +G + + E+ +R + + +QD + Sbjct: 189 LAGTTKGRLNIIDARTREIIYSEKIASGIITTLR-------LTESGRELLVNAQDRIIRT 241 Query: 243 W-----TCDDASGNMWSPKLLHKFNDVVWHVSW-----SITANILAVSGGDN-KVTLWKE 291 + + D + L HKF DVV +SW S T +A S +N ++ +W+ Sbjct: 242 FIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWER 301 Query: 292 SVDGQWVCISDVNKGQGSV 310 + + QG + Sbjct: 302 GHGSLVRMLEGPKEEQGVI 320 Score = 49.1 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 29/137 (21%), Positives = 55/137 (40%), Gaps = 20/137 (14%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIF----------DVRNGGQILIADLRGHEGPVWQ 62 +I ++ G L + DR ++ F D L + V + Sbjct: 215 SGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQ---DVVNR 271 Query: 63 VAWAH---PMYGNILASCSYDR-KVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGL 118 ++W H G +A+ +Y+ ++ IW+ +G+ + E + V + W PH L Sbjct: 272 LSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGV--IEWHPH-RAL 328 Query: 119 ILACGSSDGAISLLTYT 135 + ACG G I++ + T Sbjct: 329 LAACGLETGRINIWSVT 345 >1NR0-A nrPDB Length = 611 Score = 80.6 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 94/280 (33%), Gaps = 32/280 (11%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 + T H A+ G A+ +V+I+D IL + GPV ++W Sbjct: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWD 112 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 +R ++ + GT +G ++NSV + P + GS D Sbjct: 113 SESKRIAAVGEGRERFGHVFLFDTGT--SNGNLTGQARAMNSVDFKP-SRPFRIISGSDD 169 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 +++ ++ K HT ++V + P FAS G Sbjct: 170 NTVAIFEGPP---FKFKSTFGEHTKFVHSVRYNP-----------------DGSLFASTG 209 Query: 187 CDNLIKLWREEEDGQWKEEQKLE----AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 D I L+ + + + AHS V + W+P + IAS S D + I Sbjct: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD----GTKIASASADKTIKI 265 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 W P + D + W+ A + + G Sbjct: 266 WNVATLKVEKTIPVG-TRIEDQQLGIIWTKQALVSISANG 304 Score = 77.2 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 91/293 (31%), Gaps = 36/293 (12%) Query: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDR----SVKIFDVRNGGQILIADLRGHEGP 59 ++ T + D D R+A R V +FD +L G Sbjct: 94 ILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSN----GNLTGQARA 149 Query: 60 VWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 + V + P + S S D V I++ ++ T H V+SV + P G + Sbjct: 150 MNSVDFK-PSRPFRIISGSDDNTVAIFEGPPFKFKST--FGEHTKFVHSVRYNPD--GSL 204 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 A DG I L + V + ++ + + + P Sbjct: 205 FASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGT------------ 252 Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 K AS D IK+W K D + W + S S +G Sbjct: 253 -KIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW------TKQALVSISANG- 304 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 FI + G++ + + N + +S S L + + + W S Sbjct: 305 -FINFVNPELGSIDQVR--YGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 Score = 71.0 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 51/346 (14%), Positives = 103/346 (29%), Gaps = 68/346 (19%) Query: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRN----------------------GG 46 + +H + GT++A+ S+D+++KI++V Sbjct: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 Query: 47 QILIADLR-------------------GHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 Q L++ GH + A + G L S + + W Sbjct: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAIT--ALSSSADGKTLFSADAEGHINSWD 352 Query: 88 EENGTWEKTH----------EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGE 137 G + + + +V W ++ A GS + + Sbjct: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWD-DHLKVVPAGGSGVDSSKAVANKLS 411 Query: 138 GQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS-------GQKPNYIKKFASGGCDNL 190 Q ++ I A A+ + + N + A GG D+ Sbjct: 412 SQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSK 471 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 + +++ E K H + VA++ + + + + Q +V ++ + + Sbjct: 472 VHVYKLSGAS--VSEVKTIVHPAEITSVAFSNN----GAFLVATDQSRKVIPYSVAN-NF 524 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 + V VSWS LA DN V +W + Sbjct: 525 ELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 58/185 (31%), Gaps = 27/185 (14%) Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 VA ++ +A D KV ++K + + H + + SV ++ + G L Sbjct: 452 SCVALSNDK--QFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFS--NNGAFL 506 Query: 121 ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 + + + HT VSW+P V Sbjct: 507 VATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNV----------------- 549 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 + A+G DN + +W + K V V W L +TI S QD + Sbjct: 550 RLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-----LNETTIVSAGQDSNI 604 Query: 241 FIWTC 245 W Sbjct: 605 KFWNV 609 Score = 54.1 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 31/95 (32%), Gaps = 11/95 (11%) Query: 2 VSVINTVDTSHEDM-------IHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR 54 SV N + +H + + RLAT S D SV ++++ I Sbjct: 518 YSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKG 577 Query: 55 GHE-GPVWQVAWAHPMYGNILASCSYDRKVIIWKE 88 H V V W + + S D + W Sbjct: 578 AHAMSSVNSVIW---LNETTIVSAGQDSNIKFWNV 609 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 53/322 (16%), Positives = 98/322 (30%), Gaps = 67/322 (20%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI-----ADL-----R 54 I+ V H I G L + ++ + +D+ G + A + Sbjct: 316 IDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKT 375 Query: 55 GHEGPVWQVAW---------------AHPMYGNILAS------CSYDRKVIIWKEENGTW 93 +G ++ V+W + N L+S S D + + Sbjct: 376 TSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAV-----AAC 430 Query: 94 EKTHEHSGHDS------SVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINN 147 K H S NS C A + +A G D + + +G EVK I Sbjct: 431 YKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV- 489 Query: 148 AHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQK 207 H +V+++ + + + + + Sbjct: 490 -HPAEITSVAFSNNGAF-----------------LVATDQSRKVIPYSVANNFELAHTNS 531 Query: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWH 267 H+ V V+W+P +A+ S D V +W + S + K H + V Sbjct: 532 WTFHTAKVACVSWSPDNVR----LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSS-VNS 586 Query: 268 VSWSITANILAVSGGDNKVTLW 289 V W + + +G D+ + W Sbjct: 587 VIW-LNETTIVSAGQDSNIKFW 607 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 31/205 (15%), Positives = 60/205 (29%), Gaps = 28/205 (13%) Query: 85 IWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 ++ G+ T ++ H +P G A G G + + T +K Sbjct: 41 VYTVPVGSLTDTEIYTEHSHQTTVAKTSP--SGYYCASGDVHGNVRIWDTTQTTHI-LKT 97 Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKE 204 + +SW + ++ ++ F +G Sbjct: 98 TIPVFSGPVKDISWD-SESKRIAAVGEGRERFGHVFLFDTGT-----------------S 139 Query: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDV 264 L + + V + PS I S S D V I+ + Sbjct: 140 NGNLTGQARAMNSVDFKPSRPF---RIISGSDDNTVAIFE----GPPFKFKSTFGEHTKF 192 Query: 265 VWHVSWSITANILAVSGGDNKVTLW 289 V V ++ ++ A +GGD + L+ Sbjct: 193 VHSVRYNPDGSLFASTGGDGTIVLY 217 >2PM9-A nrPDB Length = 416 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 93/295 (31%), Gaps = 23/295 (7%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 S T SH+ + GT A S+D S++++ + + Sbjct: 12 FSRTATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFN 71 Query: 62 QVAWAHPMYGNILASCSYDRKVIIW--KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI 119 + W+H I+A + + ++ E N S H SSV +V + + Sbjct: 72 DLDWSH--NNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQ-DNV 128 Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 LA G ++G I + E N P S+ + S + Sbjct: 129 LASGGNNGEIFIWDMNK--CTESPS---------NYTPLTPGQSMSSVDEVISLAWNQSL 177 Query: 180 KK-FASGGCDNLIKLWREEEDG---QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS 235 FAS G N +W + + V W P +T Sbjct: 178 AHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSD 237 Query: 236 QDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSW-SITANILAVSGGDNKVTLW 289 D + IW +A+ + L + + W ++L SG DN V LW Sbjct: 238 NDPSILIWDLRNANTPLQ--TLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLW 290 Score = 71.8 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 42/289 (14%), Positives = 85/289 (29%), Gaps = 36/289 (12%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDV--RNGGQILIADLRGHEGPVWQVAWAHPMY 70 + +D + +A + S++++ N +A H V V + + Sbjct: 67 DSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKF-NAKQ 125 Query: 71 GNILASCSYDRKVIIWKEE-------NGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 N+LAS + ++ IW N T + V S+ W + A Sbjct: 126 DNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN-QSLAHVFASA 184 Query: 124 SSDGAISLLTYTGEGQW---EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 S S+ + + N+ + V W P + + Sbjct: 185 GSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHP-------------KNSTRVA 231 Query: 181 KFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV 240 D I +W + + + H + + W + S +D V Sbjct: 232 TATGSDNDPSILIWDL-RNANTPLQTLNQGHQKGILSLDW---CHQDEHLLLSSGRDNTV 287 Query: 241 FIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL-AVSGGDNKVTL 288 +W + A + + ++ A L A + DNK+ + Sbjct: 288 LLWNPESAE----QLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 33/133 (24%), Positives = 54/133 (40%), Gaps = 11/133 (8%) Query: 29 ATCSS-DRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 AT S D S+ I+D+RN L +GH+ + + W H ++L S D V++W Sbjct: 233 ATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCH-QDEHLLLSSGRDNTVLLWN 291 Query: 88 EENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS------LLTYTGEGQWE 141 E+ E+ + + +AP + + AC S D I L E + E Sbjct: 292 PESA--EQLSQFPARGNWCFKTKFAP-EAPDLFACASFDNKIEVQTLQNLTNTLDEQETE 348 Query: 142 VKKINNAHTIGCN 154 K+ + N Sbjct: 349 TKQQESETDFWNN 361 Score = 44.4 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 46/108 (42%), Gaps = 6/108 (5%) Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 D+ ++LW K L+ S + D+ W+ + IA +G + +++ Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSHN----NKIIAGALDNGSLELYST 96 Query: 246 DDASGNMWSPKLLHKFNDVVWHVSWSITA-NILAVSGGDNKVTLWKES 292 ++A+ + S + V V ++ N+LA G + ++ +W + Sbjct: 97 NEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMN 144 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 35/87 (40%), Gaps = 4/87 (4%) Query: 5 INTVDTSHEDMIHDAQM-DYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 + T++ H+ I L + D +V +++ + Q ++ ++ Sbjct: 254 LQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQ--LSQFPARGNWCFKT 311 Query: 64 AWAHPMYGNILASCSYDRKVIIWKEEN 90 +A P ++ A S+D K+ + +N Sbjct: 312 KFA-PEAPDLFACASFDNKIEVQTLQN 337 >5CXC-A nrPDB Length = 510 Score = 79.9 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 94/331 (28%), Gaps = 74/331 (22%) Query: 21 MDYYGTRLATCSSDRSVKIFDVRNG--GQILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 + R+ + S D ++I++ GH + + + LAS Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLT---SDRLASAG 210 Query: 79 YDRKVIIW-----KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 DR V +W G + T E GH SV+ + H ++ S+DGAI + Sbjct: 211 MDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL--TASADGAIGFWS 268 Query: 134 YTGEGQWEVKK--INNAHT-----------------IGCNAVSWAPAVV----PGSLIDQ 170 + E + AH +G ++ APA P Sbjct: 269 ASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVA 328 Query: 171 PSGQKPNYIKK---------------------------------FASGGCDNLIKLWREE 197 S + + ++ A+G I + Sbjct: 329 YSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 198 EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKL 257 L H++ V ++ +P ++ S S DG +W Sbjct: 389 ASSATTSVMTLRGHANKVVSLSPSPE---NEYSLVSGSHDGTCRVWDLRSVRPATKEEGS 445 Query: 258 LHKFNDVVW---HVSWSITANILAVSGGDNK 285 L ++ V+ SW+ GD Sbjct: 446 LGGVSEPVYVIERESWASKGKKKRPVAGDGC 476 Score = 51.8 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 40/129 (31%), Gaps = 21/129 (16%) Query: 211 HSDWVRDVAWAPSIGLPTS----------------TIASCSQDGRVFIWTCDDASGNMWS 254 H DWV V + + S S DG + IW + Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSP 184 Query: 255 PKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK----ESVDGQWVCISDVNKGQGSV 310 + + +T++ LA +G D V +WK + G+ ++ GSV Sbjct: 185 SGSHGGHTASIKAAKF-LTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSV 243 Query: 311 SASITEGQQ 319 +G Sbjct: 244 DWLDVDGHS 252 >5CXB-B nrPDB Length = 369 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 60/364 (16%), Positives = 103/364 (28%), Gaps = 83/364 (22%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 +V T+ HE + +D G LAT D +V+++++ G Q+ L G + V Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNT 69 Query: 63 VAWAHPMYGNIL-ASCSYDRKVII--------------WKEEN----------------- 90 V W IL A+ D ++I N Sbjct: 70 VRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPP 129 Query: 91 -----GTWEKTHEHSGHDS-----SVNSV--CWAPHDYGLILACGSSDGAISLLTYTGEG 138 G W + + +V S + H G A S G S + Sbjct: 130 GKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLS 189 Query: 139 QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK----------------- 181 + + S+ P + Q S + + K Sbjct: 190 KHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPGAKWISSFD 249 Query: 182 -------FASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASC 234 G D + LW + + + + H++ +R V + A Sbjct: 250 VHPGGDNLVVGSYDKRL-LWHDLDLSNRPY-KTMRFHTEAIRAVRFH---KGGLPLFADA 304 Query: 235 SQDGRVFIWTCDDASGNMWSPKL-----LHKFNDV----VWHVSWSITANILAVSGGDNK 285 S DG + I+ + + +P + L V V + W +G D Sbjct: 305 SDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGT 364 Query: 286 VTLW 289 LW Sbjct: 365 ARLW 368 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 3/83 (3%) Query: 41 DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHS 100 +++ + RGHEG V VA G LA+ D V +W+ G + + + Sbjct: 5 ELKPFPTVQQTIFRGHEGRVRSVAI--DPTGVALATGGDDGTVRVWELLTGRQVWSVKLN 62 Query: 101 GHDSSVNSVCWAPHDYGLILACG 123 G D +VN+V W P ILA Sbjct: 63 G-DEAVNTVRWRPTKDTFILAAA 84 Score = 51.0 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 28/86 (32%), Gaps = 4/86 (4%) Query: 87 KEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 + + + GH+ V SV P G+ LA G DG + + Q K+N Sbjct: 5 ELKPFPTVQQTIFRGHEGRVRSVAIDP--TGVALATGGDDGTVRVWELLTGRQVWSVKLN 62 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPS 172 N V W P L Sbjct: 63 GDEA--VNTVRWRPTKDTFILAAAAG 86 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 13/37 (35%) Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + V V+ T LA G D V +W+ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWE 49 >6CB1-s nrPDB Length = 569 Score = 77.2 bits (188), Expect = 8e-15, Method: Composition-based stats. Identities = 57/343 (16%), Positives = 103/343 (30%), Gaps = 65/343 (18%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP----VWQ 62 T+ H+ + +D G LAT S D +V+++++ G ++ L E + Sbjct: 193 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 252 Query: 63 VAWAHPMYGNILASCSYDRKVII------WKEENGTWEKTHEHSGHD--SSVNSVCWAPH 114 + W ILA + +I + EN K + G+D +V + Sbjct: 253 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 312 Query: 115 DYGLILACGSSDG-----------AISLLTYTGEGQWEVKK-INNAHTIGCNAVSWA--- 159 + G G DG ++ + Q E I + +SW Sbjct: 313 ENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKG 368 Query: 160 -PAVVPGSLIDQPSGQKPNYIKKFASGGCDNL-----------------------IKLWR 195 V S K ++++ Sbjct: 369 DYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYD 428 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 Q +KL + W+ + P + IAS S D RV D AS Sbjct: 429 L---SQQILVKKLLPGARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPY--- 478 Query: 256 KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 K L V V++ + + + D + ++ +V + Sbjct: 479 KTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMM 521 Score = 67.6 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 71/192 (36%), Gaps = 35/192 (18%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 + +I DA+ + +L CS R V+I+D+ QIL+ L + ++ HP N Sbjct: 401 KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQ--QILVKKLLPGARWLSKIDI-HPRGDN 456 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ++AS S+D++V +W + + H+ +V SV + H + + + DG I + Sbjct: 457 LIAS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADDGTIHVF 512 Query: 133 ------TYTGEGQWEVKKINNAHT----IGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 K H +G W P Sbjct: 513 HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREA-----------------WL 555 Query: 183 ASGGCDNLIKLW 194 S G DN +LW Sbjct: 556 FSAGADNTARLW 567 Score = 54.1 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 79/300 (26%), Gaps = 61/300 (20%) Query: 41 DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHS 100 D+R GH+G V ++ G LA+ S D V +W+ G Sbjct: 183 DLRPFPIRCSTIYAGHKGKVRTLSI--DPSGLWLATGSDDGTVRVWEILTGREVYRTTLI 240 Query: 101 G----HDSSVNSVCWAPHDYGLILACGSSDGA------ISLLTYTGEGQWEVKKINNAHT 150 D + + W P ILA + I G+ +++ T Sbjct: 241 DDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDT 300 Query: 151 IG-CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA-----------------SGGCDNLIK 192 G + D + N +KK + C +K Sbjct: 301 FGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVK 360 Query: 193 --LWREEED-------------------GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 W + D + + + + D + P + Sbjct: 361 KLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP----FKPQL 416 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 CSQ V I+ K L + + + L S D +V LW + Sbjct: 417 FVCSQ-RYVRIYDL----SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHD 470 Score = 51.0 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 78/275 (28%), Gaps = 59/275 (21%) Query: 35 RSVKIFDVRNGGQIL--IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT 92 + V ++ + Q+ I + V +++W G+ + D T Sbjct: 332 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR--KGDYFVTVQPD--------SGNT 381 Query: 93 WEKTHEHSGH---------DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 H+ S H + + P L + + + + Q VK Sbjct: 382 SVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQ--QILVK 436 Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWK 203 K+ W + D + D + LW + + Sbjct: 437 KLLPG-------ARWLSKIDIHPRGDN-----------LIASSFDKRV-LWHDLDLAS-T 476 Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-----KLL 258 + L H VR V + + L +S + DG + ++ M +P K L Sbjct: 477 PYKTLRYHEKAVRSVNFHKKLPL----FSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 532 Query: 259 HKFNDV----VWHVSWSITANILAVSGGDNKVTLW 289 + V W L +G DN LW Sbjct: 533 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 29/88 (32%), Gaps = 13/88 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFD-------VRNGGQILIADLRGHEG----PV 60 HE + ++ + D ++ +F ++N + + L GH+ V Sbjct: 484 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 543 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKE 88 W HP L S D +W Sbjct: 544 LDAIW-HPREA-WLFSAGADNTARLWTT 569 Score = 32.1 bits (71), Expect = 0.32, Method: Composition-based stats. Identities = 6/35 (17%), Positives = 15/35 (42%), Gaps = 4/35 (11%) Query: 10 TSHEDM----IHDAQMDYYGTRLATCSSDRSVKIF 40 T H+ + + DA L + +D + +++ Sbjct: 533 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 >6EM1-m nrPDB Length = 807 Score = 77.2 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 57/343 (16%), Positives = 103/343 (30%), Gaps = 65/343 (18%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP----VWQ 62 T+ H+ + +D G LAT S D +V+++++ G ++ L E + Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 490 Query: 63 VAWAHPMYGNILASCSYDRKVII------WKEENGTWEKTHEHSGHD--SSVNSVCWAPH 114 + W ILA + +I + EN K + G+D +V + Sbjct: 491 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 550 Query: 115 DYGLILACGSSDG-----------AISLLTYTGEGQWEVKK-INNAHTIGCNAVSWA--- 159 + G G DG ++ + Q E I + +SW Sbjct: 551 ENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKG 606 Query: 160 -PAVVPGSLIDQPSGQKPNYIKKFASGGCDNL-----------------------IKLWR 195 V S K ++++ Sbjct: 607 DYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYD 666 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 Q +KL + W+ + P + IAS S D RV D AS Sbjct: 667 L---SQQILVKKLLPGARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPY--- 716 Query: 256 KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 K L V V++ + + + D + ++ +V + Sbjct: 717 KTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMM 759 Score = 67.6 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 71/192 (36%), Gaps = 35/192 (18%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 + +I DA+ + +L CS R V+I+D+ QIL+ L + ++ HP N Sbjct: 639 KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQ--QILVKKLLPGARWLSKIDI-HPRGDN 694 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ++AS S+D++V +W + + H+ +V SV + H + + + DG I + Sbjct: 695 LIAS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADDGTIHVF 750 Query: 133 ------TYTGEGQWEVKKINNAHT----IGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 K H +G W P Sbjct: 751 HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREA-----------------WL 793 Query: 183 ASGGCDNLIKLW 194 S G DN +LW Sbjct: 794 FSAGADNTARLW 805 Score = 54.1 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 79/300 (26%), Gaps = 61/300 (20%) Query: 41 DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHS 100 D+R GH+G V ++ G LA+ S D V +W+ G Sbjct: 421 DLRPFPIRCSTIYAGHKGKVRTLSI--DPSGLWLATGSDDGTVRVWEILTGREVYRTTLI 478 Query: 101 G----HDSSVNSVCWAPHDYGLILACGSSDGA------ISLLTYTGEGQWEVKKINNAHT 150 D + + W P ILA + I G+ +++ T Sbjct: 479 DDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDT 538 Query: 151 IG-CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA-----------------SGGCDNLIK 192 G + D + N +KK + C +K Sbjct: 539 FGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVK 598 Query: 193 --LWREEED-------------------GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 W + D + + + + D + P + Sbjct: 599 KLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP----FKPQL 654 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 CSQ V I+ K L + + + L S D +V LW + Sbjct: 655 FVCSQ-RYVRIYDL----SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHD 708 Score = 51.0 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 78/275 (28%), Gaps = 59/275 (21%) Query: 35 RSVKIFDVRNGGQIL--IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT 92 + V ++ + Q+ I + V +++W G+ + D T Sbjct: 570 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR--KGDYFVTVQPD--------SGNT 619 Query: 93 WEKTHEHSGH---------DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 H+ S H + + P L + + + + Q VK Sbjct: 620 SVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQ--QILVK 674 Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWK 203 K+ W + D + D + LW + + Sbjct: 675 KLLPG-------ARWLSKIDIHPRGDN-----------LIASSFDKRV-LWHDLDLAS-T 714 Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-----KLL 258 + L H VR V + + L +S + DG + ++ M +P K L Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLPL----FSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 259 HKFNDV----VWHVSWSITANILAVSGGDNKVTLW 289 + V W L +G DN LW Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 29/88 (32%), Gaps = 13/88 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFD-------VRNGGQILIADLRGHEG----PV 60 HE + ++ + D ++ +F ++N + + L GH+ V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKE 88 W HP L S D +W Sbjct: 782 LDAIW-HPREA-WLFSAGADNTARLWTT 807 Score = 32.1 bits (71), Expect = 0.32, Method: Composition-based stats. Identities = 6/35 (17%), Positives = 15/35 (42%), Gaps = 4/35 (11%) Query: 10 TSHEDM----IHDAQMDYYGTRLATCSSDRSVKIF 40 T H+ + + DA L + +D + +++ Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >6F1U-h nrPDB Length = 612 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 101/293 (34%), Gaps = 36/293 (12%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADL----RGHEGPVWQVAWAHPMYGNIL 74 A+ + + + ++D R+ + + H PV+ V + L Sbjct: 315 AKFHPN--LVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDS----SVNSVCWAPHDYGLILACGSSDGAIS 130 S S D K+ W + + + H +V S+ + P GS +G++ Sbjct: 373 ISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEGSVY 431 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 + + ++ H + AV ++ F + D Sbjct: 432 -TACRHGSKAGISEMFEGHQGPITGIHCHAAV-----------GAVDFSHLFVTSSFDWT 479 Query: 191 IKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 +KLW + + K E ++ +V DV W+P+ + A GR+ +W ++ + Sbjct: 480 VKLWSTKNN---KPLYSFEDNAGYVYDVMWSPTHP---ALFACVDGMGRLDLWNLNNDTE 533 Query: 251 NMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES------VDGQW 297 + + N + V W+ + +AV + ++ ++ + +W Sbjct: 534 VPTASISVEG-NPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEW 585 >6C0F-s nrPDB Length = 807 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 57/343 (16%), Positives = 103/343 (30%), Gaps = 65/343 (18%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP----VWQ 62 T+ H+ + +D G LAT S D +V+++++ G ++ L E + Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 490 Query: 63 VAWAHPMYGNILASCSYDRKVII------WKEENGTWEKTHEHSGHD--SSVNSVCWAPH 114 + W ILA + +I + EN K + G+D +V + Sbjct: 491 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 550 Query: 115 DYGLILACGSSDG-----------AISLLTYTGEGQWEVKK-INNAHTIGCNAVSWA--- 159 + G G DG ++ + Q E I + +SW Sbjct: 551 ENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKG 606 Query: 160 -PAVVPGSLIDQPSGQKPNYIKKFASGGCDNL-----------------------IKLWR 195 V S K ++++ Sbjct: 607 DYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYD 666 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 Q +KL + W+ + P + IAS S D RV D AS Sbjct: 667 L---SQQILVKKLLPGARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPY--- 716 Query: 256 KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 K L V V++ + + + D + ++ +V + Sbjct: 717 KTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMM 759 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 71/192 (36%), Gaps = 35/192 (18%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 + +I DA+ + +L CS R V+I+D+ QIL+ L + ++ HP N Sbjct: 639 KGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQ--QILVKKLLPGARWLSKIDI-HPRGDN 694 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL 132 ++AS S+D++V +W + + H+ +V SV + H + + + DG I + Sbjct: 695 LIAS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADDGTIHVF 750 Query: 133 ------TYTGEGQWEVKKINNAHT----IGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKF 182 K H +G W P Sbjct: 751 HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREA-----------------WL 793 Query: 183 ASGGCDNLIKLW 194 S G DN +LW Sbjct: 794 FSAGADNTARLW 805 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 79/300 (26%), Gaps = 61/300 (20%) Query: 41 DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHS 100 D+R GH+G V ++ G LA+ S D V +W+ G Sbjct: 421 DLRPFPIRCSTIYAGHKGKVRTLSI--DPSGLWLATGSDDGTVRVWEILTGREVYRTTLI 478 Query: 101 G----HDSSVNSVCWAPHDYGLILACGSSDGA------ISLLTYTGEGQWEVKKINNAHT 150 D + + W P ILA + I G+ +++ T Sbjct: 479 DDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDT 538 Query: 151 IG-CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA-----------------SGGCDNLIK 192 G + D + N +KK + C +K Sbjct: 539 FGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVK 598 Query: 193 --LWREEED-------------------GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTI 231 W + D + + + + D + P + Sbjct: 599 KLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP----FKPQL 654 Query: 232 ASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKE 291 CSQ V I+ K L + + + L S D +V LW + Sbjct: 655 FVCSQ-RYVRIYDL----SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHD 708 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 78/275 (28%), Gaps = 59/275 (21%) Query: 35 RSVKIFDVRNGGQIL--IADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGT 92 + V ++ + Q+ I + V +++W G+ + D T Sbjct: 570 KQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR--KGDYFVTVQPD--------SGNT 619 Query: 93 WEKTHEHSGH---------DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 H+ S H + + P L + + + + Q VK Sbjct: 620 SVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS---QRYVRIYDLSQ--QILVK 674 Query: 144 KINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWK 203 K+ W + D + D + LW + + Sbjct: 675 KLLPG-------ARWLSKIDIHPRGDN-----------LIASSFDKRV-LWHDLDLAS-T 714 Query: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP-----KLL 258 + L H VR V + + L +S + DG + ++ M +P K L Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLPL----FSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 259 HKFNDV----VWHVSWSITANILAVSGGDNKVTLW 289 + V W L +G DN LW Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 47.5 bits (111), Expect = 7e-06, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 29/88 (32%), Gaps = 13/88 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFD-------VRNGGQILIADLRGHEG----PV 60 HE + ++ + D ++ +F ++N + + L GH+ V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKE 88 W HP L S D +W Sbjct: 782 LDAIW-HPREA-WLFSAGADNTARLWTT 807 Score = 32.1 bits (71), Expect = 0.34, Method: Composition-based stats. Identities = 6/35 (17%), Positives = 15/35 (42%), Gaps = 4/35 (11%) Query: 10 TSHEDM----IHDAQMDYYGTRLATCSSDRSVKIF 40 T H+ + + DA L + +D + +++ Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >5K0Y-T nrPDB Length = 329 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 48/324 (14%), Positives = 84/324 (25%), Gaps = 66/324 (20%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV--AWAHP 68 HE I + + G L T + D V ++ NG + + GH G VW V W Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGER--LGTYMGHTGAVWCVDADWDTK 65 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 + + S D +W E G K +S+V + + ++ S+D Sbjct: 66 H----VLTGSADNSCRLWDCETG---KQLALLKTNSAVRTCGFDFGGNIIMF---STDKQ 115 Query: 129 ------ISLLTYTGEGQW---EVKKINNAHTIGCNAVSWAPA------------------ 161 +S Q E + + W P Sbjct: 116 MGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSA 175 Query: 162 -------VVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDW 214 V Q + F + DN KL+ K + Sbjct: 176 KSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRE-- 233 Query: 215 VRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP----------KLLHKFNDV 264 A +P+ + + + T G + + Sbjct: 234 --LAALSPN----YEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGP 287 Query: 265 VWHVSWSITANILAVSGGDNKVTL 288 + V++ + G D V + Sbjct: 288 INSVAFHPDGKSYSSGGEDGYVRI 311 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 30/137 (21%), Positives = 47/137 (34%), Gaps = 21/137 (15%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H I+D Q+ T T S D + K+FD + R P ++A P Y Sbjct: 187 HSRQINDIQLSREMTMFVTASKDNTAKLFD--STTLEHQKTFR--TEPPRELAALSPNYE 242 Query: 72 NILASCS---YDRKVIIWKEENGTWEKTHEH----------SGHDSSVNSVCWAPHDYGL 118 +++ D G +E H GH +NSV + P G Sbjct: 243 HVVVGGGQEAMDVTTT--STRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPD--GK 298 Query: 119 ILACGSSDGAISLLTYT 135 + G DG + + + Sbjct: 299 SYSSGGEDGYVRIHYFD 315 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 24/83 (28%), Gaps = 8/83 (9%) Query: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWH 267 L+ H + + + + + ++D V +W S N VW Sbjct: 6 LQGHERSITQIKYN----REGDLLFTVAKDPIVNVW----YSVNGERLGTYMGHTGAVWC 57 Query: 268 VSWSITANILAVSGGDNKVTLWK 290 V + DN LW Sbjct: 58 VDADWDTKHVLTGSADNSCRLWD 80 Score = 36.7 bits (83), Expect = 0.012, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 15/47 (31%), Gaps = 2/47 (4%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKI--FDVRNGGQILIADLRG 55 H I+ G ++ D V+I FD + A G Sbjct: 283 GHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEAREAG 329 >3ACP-A nrPDB Length = 417 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 43/253 (16%), Positives = 79/253 (31%), Gaps = 32/253 (12%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 ++ +D +H I + G L + S D +KI+ V++G L GH V Sbjct: 125 FNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN--PRTLIGHRATVT 182 Query: 62 QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSG--HDSSVNSVCWAPHDYGLI 119 +A G + S S D + +W+ GT T HD VNS+ Sbjct: 183 DIAII--DRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDG-VNSIAL-------- 231 Query: 120 LACGSSDGAISLLTYTGEGQWEV----KKINNAHTIGCNAVS------WAPAVVPGSLID 169 +D + ++ + + E K + H G V + Sbjct: 232 --FVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCS 289 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTS 229 S + G +N + + + + L + +V +A + Sbjct: 290 CNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFA-----AGA 344 Query: 230 TIASCSQDGRVFI 242 S D + + Sbjct: 345 LFVSSGFDTSIKL 357 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 56/158 (35%), Gaps = 11/158 (6%) Query: 133 TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 T+ G K + H N + + + +++F G + IK Sbjct: 60 TFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIK 119 Query: 193 LWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNM 252 + + Q + +AH + + + PS + S SQD ++ IW+ D S Sbjct: 120 VLDSNFNLQ---REIDQAHVSEITKLKFFPS----GEALISSSQDMQLKIWSVKDGS--- 169 Query: 253 WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 +P+ L V ++ + + D + LW+ Sbjct: 170 -NPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWE 206 Score = 45.6 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 49/144 (34%), Gaps = 34/144 (23%) Query: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI 179 G+++G I +L Q ++I+ AH + + P+ Sbjct: 109 FILGTTEGDIKVLDSNFNLQ---REIDQAHVSEITKLKFFPS-----------------G 148 Query: 180 KKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 + S D +K+W ++ + L H V D+A I + S S DG Sbjct: 149 EALISSSQDMQLKIWSVKDGSN---PRTLIGHRATVTDIA----IIDRGRNVLSASLDGT 201 Query: 240 VFIWTCDDASGNMWSPKLLHKFND 263 + +W C +H FN Sbjct: 202 IRLWECGTG-------TTIHTFNR 218 >5BJS-A nrPDB Length = 605 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 37/175 (21%), Positives = 60/175 (34%), Gaps = 15/175 (8%) Query: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 L ++ +VK+++V G L L GH G + +A P I+AS S D + IW Sbjct: 150 LLCIAGNEGNVKVYNVTEGK--LYRTLVGHGGGINDLA-TSPANPYIIASASDDTTIRIW 206 Query: 87 KE----ENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLL---TYTGEGQ 139 E GH + SV + HD G + D I+L + E Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAF--HDNGRYVLSAGHDQVINLWALPEFPNEHM 264 Query: 140 WEVKKINNAHTIG---CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 I H N + A ++ + + + + D+ I Sbjct: 265 EIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIEGFSSDDPI 319 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 40/107 (37%), Gaps = 8/107 (7%) Query: 185 GGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWT 244 G + +K++ E + + L H + D+A +P IAS S D + IW+ Sbjct: 154 AGNEGNVKVYNVTEGKLY---RTLVGHGGGINDLATSP---ANPYIIASASDDTTIRIWS 207 Query: 245 CDDASGNMWSPKLL--HKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 +L + + V++ + +G D + LW Sbjct: 208 LAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 60.6 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 51/142 (35%), Gaps = 21/142 (14%) Query: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNG----GQILIADLRGHEGPVWQVAW 65 H I+D +A+ S D +++I+ + + I GH + VA+ Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 66 AHPMYGNILASCSYDRKVIIW---KEENGTWEKTHEH--------SGHDSSVNSVCWAPH 114 H G + S +D+ + +W + N E H++ V+ V + Sbjct: 236 -HD-NGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY-- 291 Query: 115 DYGLILACGSSDGAISLLTYTG 136 LIL+ + I L G Sbjct: 292 -GDLILSRACHEDTIVLWRIEG 312 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 78/246 (31%), Gaps = 44/246 (17%) Query: 65 WAHPMYGNILASCSYDRKVIIW-----KEENGTWEKTHEHSGHDSSVNS-VCWA--PHDY 116 ++ P + A+ S VI ++ E + N CW+ P Sbjct: 88 YSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITD 147 Query: 117 GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKP 176 +L ++G + + T + H G N ++ +PA Sbjct: 148 QPLLCIAGNEGNVKVYNVTEGKLYRTLV---GHGGGINDLATSPANPY------------ 192 Query: 177 NYIKKFASGGCDNLIKLWR---EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 AS D I++W E E E HS + VA+ + + S Sbjct: 193 ----IIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDN----GRYVLS 244 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLL---------HKFNDVVWHVSWSITANILAVSGGDN 284 D + +W + ++ N++V V++ IL+ + ++ Sbjct: 245 AGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGD-LILSRACHED 303 Query: 285 KVTLWK 290 + LW+ Sbjct: 304 TIVLWR 309 Score = 40.6 bits (93), Expect = 9e-04, Method: Composition-based stats. Identities = 14/95 (14%), Positives = 33/95 (34%), Gaps = 18/95 (18%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI-----------ADLRGHEGP 59 H + G + + D+ + ++ + + + H Sbjct: 225 GHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNL 284 Query: 60 VWQVAWAHPMYGNILAS--CSYDRKVIIWKEENGT 92 V VA+ YG+++ S C D +++W+ E + Sbjct: 285 VDCVAF----YGDLILSRACHED-TIVLWRIEGFS 314 Score = 37.5 bits (85), Expect = 0.008, Method: Composition-based stats. Identities = 10/90 (11%), Positives = 29/90 (32%), Gaps = 5/90 (5%) Query: 220 WAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL-A 278 W+ + +G V ++ + + L + ++ S + A Sbjct: 140 WSKDPITDQPLLCIAGNEGNVKVYNVTEGK----LYRTLVGHGGGINDLATSPANPYIIA 195 Query: 279 VSGGDNKVTLWKESVDGQWVCISDVNKGQG 308 + D + +W + + + + G+G Sbjct: 196 SASDDTTIRIWSLAPEHEKQPCVCILGGEG 225 >5MWJ-A nrPDB Length = 337 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 91/294 (30%), Gaps = 59/294 (20%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY- 70 H +++ + + T VK++D+ + G++ PV Q+ + Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHP---------GNKSPVSQLDCLNRDNY 99 Query: 71 ---------GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 G L + IW T E + + ++ +P D + + Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISP-DSKVCFS 158 Query: 122 CGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKK 181 C S DG I++ + + + HT G + + N K Sbjct: 159 CCS-DGNIAVWDLHNQ---TLVRQFQGHTDGASCI-----------------DISNDGTK 197 Query: 182 FASGGCDNLIKLWREEEDGQWKEEQKLEAH--SDWVRDVAWAPSIGLPTSTIASCSQDGR 239 +GG DN ++ W E Q L+ H + + + + P+ + S Sbjct: 198 LWTGGLDNTVRSWDLREGRQ------LQQHDFTSQIFSLGYCPTGEWLAVGMESS----- 246 Query: 240 VFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 + N LH V + ++ +G DN + W+ Sbjct: 247 ----NVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPY 296 Score = 62.2 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 35/246 (14%), Positives = 71/246 (28%), Gaps = 38/246 (15%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENG---TWEKTHEHSGHDSSVNSVCWA 112 H V V ++P + + V +W + + + D+ + S Sbjct: 50 HGEVVCAVTISNPT--RHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLL 106 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P G L G +S+ +K + C A++ +P Sbjct: 107 PD--GCTLIVGGEASTLSIWDLAAP-TPRIKAELTSSAPACYALAISP------------ 151 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 K S D I +W ++ + H+D + I + + Sbjct: 152 -----DSKVCFSCCSDGNIAVWDLHNQ---TLVRQFQGHTDGASCI----DISNDGTKLW 199 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 + D V W + H F ++ + + T LAV + V + + Sbjct: 200 TGGLDNTVRSWDLREGRQLQQ-----HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVN 254 Query: 293 VDGQWV 298 ++ Sbjct: 255 KPDKYQ 260 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 43/129 (33%), Gaps = 10/129 (7%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D + GT+L T D +V+ +D+R G Q+ D ++ + + Sbjct: 181 GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDF---TSQIFSLGYCP--T 235 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 G LA V + ++ H+S V S+ +A G D ++ Sbjct: 236 GEWLAVGMESSNVEVLHVNKPDK---YQLHLHESCVLSLKFA--YCGKWFVSTGKDNLLN 290 Query: 131 LLTYTGEGQ 139 Sbjct: 291 AWRTPYGAS 299 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 11/77 (14%), Positives = 25/77 (32%), Gaps = 5/77 (6%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 HE + + Y G + D + + G I + V + + Sbjct: 264 HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK---ESSSVLSCDIS--VDD 318 Query: 72 NILASCSYDRKVIIWKE 88 + + S D+K +++ Sbjct: 319 KYIVTGSGDKKATVYEV 335 >6BX3-B nrPDB Length = 412 Score = 72.6 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 41/285 (14%), Positives = 92/285 (32%), Gaps = 29/285 (10%) Query: 18 DAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI--ADLRGHEGPVWQVAWAHPMYGNILA 75 Q G LA ++ ++ I+D+ I + L H P+ +AW+ G +L Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD--GRLLL 87 Query: 76 SCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT 135 + S D + +W K + DS + W L +A + ++ ++ Sbjct: 88 TSSRDWSIKLWDLS--KPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 145 Query: 136 GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWR 195 + + ++ + + P + G + ++ Sbjct: 146 NDPVASLLSKSDEKQL---------SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 196 Query: 196 EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSP 255 Q + L+ S ++ + + + +A D + + N Sbjct: 197 FHSLYQTECIHSLKITSSNIKHLIVSQN----GERLAINCSDRTIRQYEISIDDENSAVE 252 Query: 256 KLL-HKFNDVVWHVSW------SITANILAV---SGGDNKVTLWK 290 L HK+ DV+ + W + TA L +++ +W+ Sbjct: 253 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 297 Score = 55.6 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 97/301 (32%), Gaps = 28/301 (9%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIL-IADLRGHEGPVWQVAWAHPM 69 +H I G L T S D S+K++D+ + L + P+W W Sbjct: 69 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF---DSPIWGCQWLDAK 125 Query: 70 YGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 +A+ + + N S + P D+G +L C Sbjct: 126 RRLCVATIFEESDAYVIDFSNDPVASLL----SKSDEKQLSSTP-DHGYVLVCTVHTKHP 180 Query: 130 SLLTYTGEGQW-EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 +++ W + K ++ + C + LI +G ++ A D Sbjct: 181 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNG------ERLAINCSD 234 Query: 189 NLIKLWREEEDGQWKEEQKLEAHS--DWVRDVAWAP---SIGLPTSTIAS--CSQDGRVF 241 I+ + D + + H D + + W S +AS S ++ Sbjct: 235 RTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELY 294 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGD-NKVTLWKESVDGQWVCI 300 IW ++L + + ++W + + +G + V +W + +W + Sbjct: 295 IWETTSG----TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL 350 Query: 301 S 301 + Sbjct: 351 A 351 Score = 55.6 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 33/273 (12%), Positives = 75/273 (27%), Gaps = 31/273 (11%) Query: 47 QILIADLRGHEGPVW----------QVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKT 96 Q A L+ H + + ++ G+ LA + ++I+ + Sbjct: 5 QDPFAVLKEHPEKLTHTIENPLRTECLQFSP--CGDYLALGCANGALVIYDMDTFRPICV 62 Query: 97 HE--HSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCN 154 H + S+ W+P G +L S D +I L + + + ++ GC Sbjct: 63 PGNMLGAHVRPITSIAWSPD--GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 120 Query: 155 AVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDW 214 + + D + L + ++ Q + Sbjct: 121 WL-------DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD----HGY 169 Query: 215 VRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITA 274 V S + L + + H+ S Sbjct: 170 VLVCTVHTKHPNIIIVGTSKGWLDFYKF----HSLYQTECIHSLKITSSNIKHLIVSQNG 225 Query: 275 NILAVSGGDNKVTLWKESVDGQWVCISDVNKGQ 307 LA++ D + ++ S+D + + + + Sbjct: 226 ERLAINCSDRTIRQYEISIDDENSAVELTLEHK 258 >5OV3-A nrPDB Length = 381 Score = 68.7 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 100/297 (33%), Gaps = 35/297 (11%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 + ++H + G +L + S+D V +DV +G P+ +V + H Sbjct: 62 IISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRF---PSPILKVQY-H 117 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 P N + C ++ T S H V D + S D Sbjct: 118 PRDQNKVLVCPM---------KSAPVMLTLSDSKH------VVLPVDDDSDLNVVASFDR 162 Query: 128 AIS-LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGG 186 + T +G+ V K ++ + S+ + S + F Sbjct: 163 RGEYIYTGNAKGKILVLKTDSQDLVA----SFRVTTGTSNTTAIKSIEFARKGSCFLINT 218 Query: 187 CDNLIKLWREEED---GQWKEEQKLEAHSDWVRDVAW--APSIGLPTSTIASCSQDGRVF 241 D +I+++ E G+ E + ++ D V W G +A ++ ++ Sbjct: 219 ADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALY 278 Query: 242 IWTCDDASGNMWSPKLLHKFN-DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 IW + K+LH +++ V+W I+A V++W ++ W Sbjct: 279 IWEKSIGN----LVKILHGTRGELLLDVAWHPVRPIIASISS-GVVSIWAQNQVENW 330 Score = 54.5 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 37/268 (13%), Positives = 73/268 (27%), Gaps = 41/268 (15%) Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLIL 120 + +G +LA D +++IW K S H V S+CW+ G L Sbjct: 27 MALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKI--ISAHIHPVCSLCWSRD--GHKL 82 Query: 121 ACGSSDGAISLLTYTGEGQ------WEVKKINNAHTIGCNAVSWAPAVV----------- 163 S+D +S H N V P Sbjct: 83 VSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSK 142 Query: 164 ------PGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDW--V 215 + +G I + + + + S+ + Sbjct: 143 HVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAI 202 Query: 216 RDVAWAPSIGLPTSTIASCSQDGRVFIWTCDD--ASGNMWSPKLLHKFNDVVWHVSW--- 270 + + +A S + D + ++ + G P+ + K D+V W Sbjct: 203 KSIEFA----RKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKC 258 Query: 271 --SITANILAVSGG-DNKVTLWKESVDG 295 S + + + +W++S+ Sbjct: 259 CFSGDGEYIVAGSARQHALYIWEKSIGN 286 Score = 49.1 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 27/74 (36%), Gaps = 4/74 (5%) Query: 217 DVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI 276 +A + + +A DGR+ IW K++ V + WS + Sbjct: 26 SMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRG----IAKIISAHIHPVCSLCWSRDGHK 81 Query: 277 LAVSGGDNKVTLWK 290 L + DN V+ W Sbjct: 82 LVSASTDNIVSQWD 95 Score = 41.4 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 54/145 (37%), Gaps = 16/145 (11%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFD-------VRNGGQILIADLRG--HE 57 T TS+ I + G+ ++DR ++++D R+G + L+ + Sbjct: 193 TTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNR 252 Query: 58 GPVWQVAWAHPMYGNILASCS-YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 P + ++ G + + S + IW++ G K H + V W P Sbjct: 253 TPWKKCCFS--GDGEYIVAGSARQHALYIWEKSIGNLVKIL-HGTRGELLLDVAWHPVR- 308 Query: 117 GLILACGSSDGAISLLTYTGEGQWE 141 I+A SS G +S+ W Sbjct: 309 -PIIASISS-GVVSIWAQNQVENWS 331 Score = 35.6 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 28/203 (13%), Positives = 57/203 (28%), Gaps = 30/203 (14%) Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 + +G +LA G +DG I + + G + KI +AH ++ W+ Sbjct: 34 NRWGTLLAVGCNDGRIVIWDFLTRG---IAKIISAHIHPVCSLCWS-------------- 76 Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 K S DN++ W G + + + V + P + Sbjct: 77 ---RDGHKLVSASTDNIVSQWDVLS-GDCDQRFRFP---SPILKVQYHP--RDQNKVLVC 127 Query: 234 CSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESV 293 + V + D + +D+ S+ + K+ + K Sbjct: 128 PMKSAPVMLTLSDSKHV----VLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDS 183 Query: 294 DGQWVCISDVNKGQGSVSASITE 316 + + E Sbjct: 184 QDLVASFRVTTGTSNTTAIKSIE 206 >4J0X-A nrPDB Length = 451 Score = 68.7 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 48/335 (14%), Positives = 92/335 (27%), Gaps = 60/335 (17%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D I G + T DR + ++ + + + + G V +A+ Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAF-RKNS 170 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + ASC+ D K+ + + + GH V + + + G+ D Sbjct: 171 DQLYASCA-DFKIRTYSIN--QFSQLEILYGHHDIVEDISALAMER--CVTVGARDRTAM 225 Query: 131 LLTYTGEGQWEVKKINNAHTI-----------GCNAVSWAPAVVPGSL---IDQPSGQKP 176 L E + + + + G + P L Sbjct: 226 LWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSM 285 Query: 177 NYIKKFASGGCDNLIKLWRE-------------------------EEDGQWKEEQKLEAH 211 F +G + I LW E + +++L+ Sbjct: 286 VDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGK 345 Query: 212 S----DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWH 267 W+ + P S S G + +W D + L VV Sbjct: 346 KLLQPFWITSLYAIPYSN----VFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTK 401 Query: 268 VSWSITAN-------ILAVSGGDNKVTLWKESVDG 295 + + ILA ++++ W +V G Sbjct: 402 IQVVESGKHGKEKFRILASIAKEHRLGRWIANVSG 436 Score = 46.8 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 37/100 (37%), Gaps = 6/100 (6%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 + + E E H D + VA +P + + +D ++ +W+ + S P Sbjct: 101 TSKHEYENTTEGHYDEILTVAASPD----GKYVVTGGRDRKLIVWSTESLSPVKVIPT-- 154 Query: 259 HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 V +++ ++ L S D K+ + + Q Sbjct: 155 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLE 194 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 46/130 (35%), Gaps = 9/130 (6%) Query: 161 AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAW 220 G + + K +GG D + +W E K + V +A+ Sbjct: 108 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT-KDRRGEVLSLAF 166 Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVS 280 + ASC+ D ++ ++ + S ++L+ +D+V +S + V Sbjct: 167 RKN---SDQLYASCA-DFKIRTYSINQFS----QLEILYGHHDIVEDISALAMERCVTVG 218 Query: 281 GGDNKVTLWK 290 D LWK Sbjct: 219 ARDRTAMLWK 228 >4E5Z-B nrPDB Length = 436 Score = 68.3 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 29/273 (10%), Positives = 76/273 (27%), Gaps = 34/273 (12%) Query: 13 EDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 + + + +A S + +++ + G G + + + +P+ Sbjct: 119 DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF-NPLNT 177 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNS--VCWAPHDYGLILACGSSDGAI 129 N + S + + + ++N ++ G + G + Sbjct: 178 NQFYASSMEGTTRLQDFKGN----ILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNV 233 Query: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDN 189 LL G+ W ++ H V+ P A+ D Sbjct: 234 ILLNMDGKELWNLRM----HKKKVTHVALNP----------------CCDWFLATASVDQ 273 Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 +K+W + H V ++P + + + Q + +++ Sbjct: 274 TVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPD----GARLLTTDQKSEIRVYSASQWD 329 Query: 250 GNMWSPKLLHKFNDVVW--HVSWSITANILAVS 280 + H+ + +W N++ V Sbjct: 330 CPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 362 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 30/191 (15%), Positives = 59/191 (30%), Gaps = 29/191 (15%) Query: 103 DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 D S+ W P + A GS G I L + + + K A + + P Sbjct: 119 DRRATSLAWHPTHPSTV-AVGSKGGDIMLWNFGIKDKPTFIKGIGA-GGSITGLKFNPLN 176 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 +F + + +L + + SD + W Sbjct: 177 T----------------NQFYASSMEGTTRLQDFKGNILRVFAS-----SDTIN--IWFC 213 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITAN-ILAVSG 281 S+ + S+ + D + + +W+ ++ V HV+ + + LA + Sbjct: 214 SLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRM---HKKKVTHVALNPCCDWFLATAS 270 Query: 282 GDNKVTLWKES 292 D V +W Sbjct: 271 VDQTVKIWDLR 281 Score = 30.6 bits (67), Expect = 0.92, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 41/145 (28%), Gaps = 21/145 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEG-----PVWQVAWA 66 H ++ A G RL T ++++ L H P+ AW Sbjct: 295 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AW- 352 Query: 67 HPMYGNILASCSYD-----------RKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 HP Y I+ D R + ++ +G + + P Sbjct: 353 HPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG 412 Query: 116 YGLILACGSSDGAISLLTYTGEGQW 140 L A G I + + E + Sbjct: 413 DTLASAMGYH---ILIWSEQEEART 434 >5WLC-LN nrPDB Length = 776 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 56/321 (17%), Positives = 109/321 (33%), Gaps = 43/321 (13%) Query: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 + I ++ SH+ I+ RLA S+ +++I++ RN + G + + Sbjct: 44 ATITSLAFSHKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEG 101 Query: 63 VAWAH-PMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILA 121 + W++ L S V W G + ++ + + S+ +D L+ Sbjct: 102 LCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCN--SGVIWSISI--NDSQDKLS 157 Query: 122 CGSSDGAISLLTYT-GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK 180 G +G + L+ + G G E I ++W Sbjct: 158 VGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAW-------------------KKD 198 Query: 181 KFASGGC-DNLIKLWREEEDG-------QWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 F GGC D I++W +++ + K + S V V + P T IA Sbjct: 199 DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLP----RTDQIA 254 Query: 233 SCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 S G + W A+ N + V ++ N + +G D K+ + ++ Sbjct: 255 SGDSTGSIKFWDFQFATLNQ----SFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQN 310 Query: 293 VDGQWVCISDVNKGQGSVSAS 313 + VN + + Sbjct: 311 TNKSQKNNRWVNSSNRLLHGN 331 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 51/316 (16%), Positives = 96/316 (30%), Gaps = 61/316 (19%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIAD--LRGHEGPVWQVAWAHPMY 70 +I ++ +L+ + +V + D+ G +L D L E V +AW Sbjct: 141 SGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAW---KK 197 Query: 71 GNILASCSYDRKVIIWKEENG--------TWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + + D ++ IW + K + + V SV + P +A Sbjct: 198 DDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQ--IAS 255 Query: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGC-----NAVSWAPAVVPGSLIDQPSGQKPN 177 G S G+I + + K ++A + N ++ V + K Sbjct: 256 GDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQ 315 Query: 178 YIKK---------------------------FASGGCDNLIKLWREE--EDGQWKEEQKL 208 + SGG + + + +G +++ + Sbjct: 316 KNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTV 375 Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG---NMWSPKLLH-KFNDV 264 E +S V + + S S+ V IWT S N L K + Sbjct: 376 EPYSKNVL-------VNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLKDDQN 427 Query: 265 VWHVSWSITANILAVS 280 + S S +L V Sbjct: 428 ISTCSLSPDGQVLVVG 443 >5WLC-SG nrPDB Length = 573 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 48/335 (14%), Positives = 92/335 (27%), Gaps = 60/335 (17%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H D I G + T DR + ++ + + + + G V +A+ Sbjct: 234 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAF-RKNS 292 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 + ASC+ D K+ + + + GH V + + + G+ D Sbjct: 293 DQLYASCA-DFKIRTYSIN--QFSQLEILYGHHDIVEDISALAMER--CVTVGARDRTAM 347 Query: 131 LLTYTGEGQWEVKKINNAHTI-----------GCNAVSWAPAVVPGSL---IDQPSGQKP 176 L E + + + + G + P L Sbjct: 348 LWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSM 407 Query: 177 NYIKKFASGGCDNLIKLWRE-------------------------EEDGQWKEEQKLEAH 211 F +G + I LW E + +++L+ Sbjct: 408 VDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGK 467 Query: 212 S----DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWH 267 W+ + P S S G + +W D + L VV Sbjct: 468 KLLQPFWITSLYAIPYSN----VFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTK 523 Query: 268 VSWSITAN-------ILAVSGGDNKVTLWKESVDG 295 + + ILA ++++ W +V G Sbjct: 524 IQVVESGKHGKEKFRILASIAKEHRLGRWIANVSG 558 Score = 46.8 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 37/100 (37%), Gaps = 6/100 (6%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 + + E E H D + VA +P + + +D ++ +W+ + S P Sbjct: 223 TSKHEYENTTEGHYDEILTVAASPD----GKYVVTGGRDRKLIVWSTESLSPVKVIPT-- 276 Query: 259 HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWV 298 V +++ ++ L S D K+ + + Q Sbjct: 277 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLE 316 Score = 38.7 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 46/130 (35%), Gaps = 9/130 (6%) Query: 161 AVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAW 220 G + + K +GG D + +W E K + V +A+ Sbjct: 230 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT-KDRRGEVLSLAF 288 Query: 221 APSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVS 280 + ASC+ D ++ ++ + S ++L+ +D+V +S + V Sbjct: 289 RKN---SDQLYASCA-DFKIRTYSINQFS----QLEILYGHHDIVEDISALAMERCVTVG 340 Query: 281 GGDNKVTLWK 290 D LWK Sbjct: 341 ARDRTAMLWK 350 >5YZG-2 nrPDB Length = 646 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 66/248 (26%), Gaps = 41/248 (16%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 H + V + + + S+D V WK+ E H + S+ + Sbjct: 89 HRDVITHVVCT---KTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVS--S 143 Query: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKI--NNAHTIGCNAVSWAPAVVPGSLIDQPSG 173 G + D A+ + + K+ PG I + Sbjct: 144 EGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC--------PGDAISSVAA 195 Query: 174 QKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 + + K F G ++ KL H+ + + P + S Sbjct: 196 SEKSTGKIFIYDGR---------GDNQPLHIFDKL--HTSPLTQIRLNP----VYKAVVS 240 Query: 234 CSQDGRVFIWTCDDASGNM-----------WSPKLLHKFNDVVWHVSWSITANILAVSGG 282 + G + WT K V +S +A G Sbjct: 241 SDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGS 300 Query: 283 DNKVTLWK 290 D KV +++ Sbjct: 301 DRKVRIFR 308 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 72/239 (30%), Gaps = 27/239 (11%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H D+I + T S D VK + G + R H G + +A + G Sbjct: 89 HRDVITHVVCTKTDFII-TASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSS--EG 145 Query: 72 NILASCSYDRKVIIWKEENG---TWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 + S D+ + ++ N K G + + A S G Sbjct: 146 ALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC---PGDAISSVAASEKSTGK 202 Query: 129 ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAP----AVVPGSLIDQPSGQKPNYIKKFAS 184 I + G+ Q + + HT + P V P + KF Sbjct: 203 IFIYDGRGDNQP-LHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPK 261 Query: 185 GGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 W + D E K +A + V ++P IA+ D +V I+ Sbjct: 262 NVN------WEYKTDTDLYEFAKCKA---YPTSVCFSPD----GKKIATIGSDRKVRIF 307 Score = 48.7 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 58/185 (31%), Gaps = 7/185 (3%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 SH +I + G + D+++K+FDV N I + L G + Sbjct: 131 SHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAI 190 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 ++ AS K+ I+ H S + + P + G I Sbjct: 191 SSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYK--AVVSSDKSGMIE 248 Query: 131 LLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNL 190 T K +N + + +A S KK A+ G D Sbjct: 249 YWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYP-----TSVCFSPDGKKIATIGSDRK 303 Query: 191 IKLWR 195 ++++R Sbjct: 304 VRIFR 308 Score = 35.2 bits (79), Expect = 0.038, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 15/34 (44%) Query: 17 HDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILI 50 G ++AT SDR V+IF G + + Sbjct: 284 TSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRV 317 Score = 29.0 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 22/59 (37%), Gaps = 4/59 (6%) Query: 40 FDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHE 98 ++ + + + V ++ G +A+ DRKV I++ G + + Sbjct: 265 WEYKTDTDLYE--FAKCKAYPTSVCFSPD--GKKIATIGSDRKVRIFRFVTGKLMRVFD 319 >5K19-A nrPDB Length = 569 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 73/226 (32%), Gaps = 30/226 (13%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 E +++ G LA S D +++F+ L ++ + G + V W+ G Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFD--SVELHGTMKSYFGGLLCVCWSPD--GK 275 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP-----HDYGLILACGSSDG 127 + + D V +W + GH S V+ V + P + + GS Sbjct: 276 YIVTGGEDDLVTVWSFVD--CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD-- 331 Query: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGC 187 E ++ + S + + + +F S G Sbjct: 332 ---------EDFQDLLHFGRDRANSTQSRL--------SKRNSTDSRPVSVTYRFGSVGQ 374 Query: 188 DNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 D + LW ED + + A + A +P G +++ + Sbjct: 375 DTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 36/187 (19%), Positives = 55/187 (29%), Gaps = 46/187 (24%) Query: 103 DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 S V V W P L L SS G + L HT G A + Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSS-GNMYLYNVE-------------HTCGTTAPHYQLLK 194 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 S K N + W E + + A++P Sbjct: 195 QGESFAVHTCKSKSTR----------NPLLKWTVGEGA--------------LNEFAFSP 230 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 +A SQDG + ++ D ++ + + + V WS + G Sbjct: 231 D----GKFLACVSQDGFLRVFNFD----SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282 Query: 283 DNKVTLW 289 D+ VT+W Sbjct: 283 DDLVTVW 289 >6CHG-D nrPDB Length = 439 Score = 64.9 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 44/299 (14%), Positives = 98/299 (32%), Gaps = 46/299 (15%) Query: 18 DAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR--GHEGPVWQVAWAHPMYGNILA 75 + G LA S+ ++ I+D+ + I + H V V W++ G L Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND--GRYLW 89 Query: 76 SCSYDRKVIIWKEENGT-WEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 S D +W T + ++ G S + V W + ++T Sbjct: 90 SSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRW----------------NVCIVTV 133 Query: 135 TGE-GQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKL 193 E + + + + C + + G + P +G I Sbjct: 134 VEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINA 193 Query: 194 WREEEDGQW----KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW------ 243 ++ + + + + + + + ++ + +PS + IA D + + Sbjct: 194 FQLDLESGFEDKIRCCYEEKIANANIKQIIISPS----GTRIAINGSDRTIRQYQLIVED 249 Query: 244 -TCDDASGNMWSPKLLHKFNDVVWHVSWSI------TANILAV---SGGDNKVTLWKES 292 + S + S +L HK+ D++ + W+ + L + + LW+ S Sbjct: 250 NESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETS 308 Score = 51.0 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 44/324 (13%), Positives = 99/324 (30%), Gaps = 49/324 (15%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPV 60 ++++ T +H + G L + D K++D+ + G Sbjct: 62 IAMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSC 121 Query: 61 WQVAWAHPMYGNILASCSYDRKVIIWKEENGT--------WEKTHEHSGHDSSVNSVCWA 112 V W + + + + + E+ + SGH ++ + Sbjct: 122 HVVRWN-----VCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACP-H 175 Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 P +I+ S + Q +++ C A A + +I Sbjct: 176 PTIESIIITGTSK-------GWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSG 228 Query: 173 GQKPNYIKKFASGGCDNLIKLW------REEEDGQWKEEQKLEAHS--DWVRDVAWA--- 221 + A G D I+ + E E G H D + + W Sbjct: 229 T-------RIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIF 281 Query: 222 -PSIGLPTSTIASC--SQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILA 278 + +AS S +++W S ++L ++ + + W+ + +A Sbjct: 282 FSNHSGEY-LVASAHGSSAHDLYLWETSSGS----LVRVLEGADEELLDIDWNFYSMRIA 336 Query: 279 VSGGD-NKVTLWKESVDGQWVCIS 301 +G + V +W + +W ++ Sbjct: 337 SNGFESGWVYMWSIVIPPKWSALA 360 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 28/97 (28%) Query: 200 GQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH 259 G KE + H+ V A +A +G + I+ D Sbjct: 11 GVLKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSG 70 Query: 260 KFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 V V WS L SG D LW + + Sbjct: 71 AHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTK 107 >5WYJ-BE nrPDB Length = 939 Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 93/336 (27%), Gaps = 50/336 (14%) Query: 11 SHEDMIHDAQM-DYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEG----------- 58 H D + + S DRS+ F +R Q R H+ Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTI 407 Query: 59 -----PVWQVAWAHPMYGNI--LASCSYD-RKVIIWKEENGTWEKTHEHSGHDSSVNSVC 110 + +A + G + + D + W N + + D V SV Sbjct: 408 KSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVA 467 Query: 111 WAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQ 170 + G GSS+G+I++ + K++ G + +V L Sbjct: 468 MS--QCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGI 525 Query: 171 PSGQKPNYIKKFASGGCDNLIKLWREEEDGQW------------------KEEQKLEAHS 212 N D I + ++L HS Sbjct: 526 VGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHS 585 Query: 213 DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSI 272 + + ++P I S S D + W ++ V +S Sbjct: 586 NRITAFDFSP----EGRWIVSASLDSTIRTWDLPTGG--CIDGIIVDNVATNVK---FSP 636 Query: 273 TANILAVSG-GDNKVTLWKESVDGQWVCISDVNKGQ 307 ++LA + N + +W + V +++ + Sbjct: 637 NGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESE 672 >5AMS-A nrPDB Length = 431 Score = 63.3 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 38/294 (12%), Positives = 92/294 (31%), Gaps = 29/294 (9%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H D + + T D ++ + L G+ V ++ G Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS--EG 121 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLI--LACGSSDGAI 129 L + KV++ + + V + W + A G++DG++ Sbjct: 122 GFLVTADMSGKVLV--HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 Query: 130 SLLTY-TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 +G E H C S+ + + K + + D Sbjct: 180 WCYQINEQDGSLEQLMSGFVHQQDC------------SMGEFINTDKGENTLELVTCSLD 227 Query: 189 NLIKLWR--EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTS--TIASCSQDGRVFIWT 244 + I W + + +++ ++ AP + +A S +G + + Sbjct: 228 STIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 Query: 245 CDDASGNMWSPKLL------HKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 C++ + ++ + + + +SWS +++A+ ++ L+ S Sbjct: 288 CNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTS 341 Score = 31.7 bits (70), Expect = 0.39, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 14/36 (38%) Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 S K D V+ + ++ GGDN LW Sbjct: 57 SLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 >1PI6-A nrPDB Length = 615 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 96/274 (35%), Gaps = 27/274 (9%) Query: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 + AT +D +++++DV + L + QV G I+ S S D + Sbjct: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTL 321 Query: 84 IIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYT---GEGQW 140 ++ G E SGH+ + ++ P L GS DG I + + + Sbjct: 322 NFYEL--GHDEVLKTISGHNKGITALTVNP------LISGSYDGRIMEWSSSSMHQDHSN 373 Query: 141 EVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDG 200 + ++N+ +++SW + + G +P K AS D + D Sbjct: 374 LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQP----KVASANNDGFTAV--LTNDD 427 Query: 201 QWKEEQKLEAHSDWVRDVAWA---PSIGLPTSTIASCSQDG-RVFIWTCDDASGNMWSPK 256 Q D ++ V ++ L + +A ++G + ++ D + Sbjct: 428 DLLILQSFTG--DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 Query: 257 LLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 L + S S + +A K+ L+ Sbjct: 486 PLRAKPSYI---SISPSETYIAAGDVMGKILLYD 516 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 53/326 (16%), Positives = 97/326 (29%), Gaps = 47/326 (14%) Query: 17 HDAQMDYYGTRLA-TCSSDRSVKIFDVRNGGQILIADLRGHEGPV-WQVAWAHPMYGNIL 74 D +A C V+ D + + GH V V ++ L Sbjct: 22 THLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYL 81 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 S KVI+W D NSV +LA G IS +++ Sbjct: 82 CSGDESGKVIVWG------------WTFDKESNSVEVNVKSEFQVLA-----GPISDISW 124 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIK-----KFASGGCDN 189 EG+ G +SW G + ++K + + G D Sbjct: 125 DFEGRRLCVVGEGRDNFGV-FISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDG 183 Query: 190 LIKLWREEEDGQWKEEQKLEAHS---DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 + + + +K H +VRDV ++P + + D ++ + Sbjct: 184 SVVFY---QGPPFKFSASDRTHHKQGSFVRDVEFSPD---SGEFVITVGSDRKISCFDGK 237 Query: 247 DASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDG---QW------ 297 + ++ +SW + + A G D + +W + +W Sbjct: 238 SGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 Query: 298 ---VCISDVNKGQGSVSASITEGQQN 320 + V G G + + +G N Sbjct: 297 LGNQQVGVVATGNGRIISLSLDGTLN 322 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 48/284 (16%), Positives = 89/284 (31%), Gaps = 42/284 (14%) Query: 15 MIHDAQMDYYGTRLATCS---SDRSVKI-FDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 I D D+ G RL + V I +D N + ++ GH + Sbjct: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNS----LGEVSGHSQRINACHLKQSRP 173 Query: 71 GNILASCSYDRKVIIWKEENGTWEKT-HEHSGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 + + D V+ ++ + + H S V V ++P ++ GS D I Sbjct: 174 MRSM-TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS-DRKI 231 Query: 130 SLLTYTGEGQWEVKKINNAHTI-GCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 S + + + G A+SW +KFA+ G D Sbjct: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSW------------------LDSQKFATVGAD 273 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 I++W + ++ L+ + V + I S S DG + + Sbjct: 274 ATIRVWDVT-TSKCVQKWTLDKQQLGNQQVGV---VATGNGRIISLSLDGTLNFYELGHD 329 Query: 249 SGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 K + N + ++ + L D ++ W S Sbjct: 330 EV----LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS 365 Score = 41.0 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 26/64 (40%), Gaps = 4/64 (6%) Query: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 +AT S D ++ I+ V+ +I I L H+ V + W P L S D + Sbjct: 553 EDLVATGSLDTNIFIYSVKRPMKI-IKALNAHKDGVNNLLWETPST---LVSSGADACIK 608 Query: 85 IWKE 88 W Sbjct: 609 RWNV 612 >5A9Q-0 nrPDB Length = 380 Score = 61.8 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 32/150 (21%), Positives = 55/150 (36%), Gaps = 10/150 (6%) Query: 10 TSHEDMIHDAQMDYYGTRL-ATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 T +H + AT D + I+DVR G + ++ L+ HE +W+V + HP Sbjct: 214 TGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT-MPVSLLKAHEAEMWEVHF-HP 271 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEK--THEHSGHDSSVNSVCWAPHDYGLILACGSSD 126 L +CS D + W EK G S+ S + S Sbjct: 272 SNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISS-- 329 Query: 127 GAISLLTYTGEGQWEVKKINNAHTIGCNAV 156 L T + + E+ + + ++ N + Sbjct: 330 ---WLSTDPAKDRIEITSLLPSRSLSVNTL 356 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 93/278 (33%), Gaps = 41/278 (14%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDR-SVKIFDVRNGGQILIADLR-GH-----------EG 58 H + D Q +A S+ +V + N + H Sbjct: 73 HHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSA 132 Query: 59 PVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGL 118 P V +P + + D ++ +++ ++ +T + + S++++V + Sbjct: 133 PCTGVVCNNPE----IVTVGEDGRINLFRADHKEAVRTID-NADSSTLHAVTF--LRTPE 185 Query: 119 ILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY 178 IL S G + + + +G N S ++ + + PN Sbjct: 186 ILTVNSI-GQLKIWDFRQQG---------------NEPSQILSLTGDRVPLHCVDRHPNQ 229 Query: 179 IKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG 238 A+GG D ++ +W + L+AH + +V + PS + +CS+DG Sbjct: 230 QHVVATGGQDGMLSIWDVRQGTM--PVSLLKAHEAEMWEVHFHPS---NPEHLFTCSEDG 284 Query: 239 RVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANI 276 ++ W S + S S AN+ Sbjct: 285 SLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANV 322 Score = 41.0 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 40/253 (15%), Positives = 77/253 (30%), Gaps = 35/253 (13%) Query: 57 EGPVWQVAWAHPMYGNI-----LASCSYDR---KVIIWKE-------ENGTWEKTHEHS- 100 + + W G++ A+ S+D + +W +G +E H+ Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 101 --GHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSW 158 H V + + + + SS G +++ + Q +N T + Sbjct: 70 DIRHHGDVMDLQFFDQER---IVAASSTGCVTVFLHHPNNQ--TLSVNQQWTTA----HY 120 Query: 159 APAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDV 218 S P + + G D I L+R D + A S + V Sbjct: 121 HTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFR--ADHKEAVRTIDNADSSTLHAV 178 Query: 219 AWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITAN-IL 277 + L T I + + G++ IW L + V ++ Sbjct: 179 TF-----LRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVV 233 Query: 278 AVSGGDNKVTLWK 290 A G D +++W Sbjct: 234 ATGGQDGMLSIWD 246 >5A9Q-2 nrPDB Length = 326 Score = 59.1 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 37/198 (18%), Positives = 70/198 (35%), Gaps = 29/198 (14%) Query: 103 DSSVNSVCWAPH---DYGLILACGSSDGAISLLTYTGEGQWEVKKINNA------HTIGC 153 + V+ V + P D G ++A G ++ + E + +V+ I H + Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 154 NAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSD 213 + ++W+P SL + KF + D I+L + E + LE H+D Sbjct: 76 DGIAWSPETRLDSLPP---------VIKFCTSAADMKIRL-FTSDLQDKNEYKVLEGHTD 125 Query: 214 WVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSIT 273 ++ + + P IAS S D IW + + + V W Sbjct: 126 FINGLVFDP---KEGQEIASVSDDHTCRIWNLEGVQTAHFVL------HSPGMSVCWHPE 176 Query: 274 ANI-LAVSGGDNKVTLWK 290 L V+ + + + Sbjct: 177 ETFKLMVAEKNGTIRFYD 194 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 47/296 (15%), Positives = 89/296 (30%), Gaps = 59/296 (19%) Query: 13 EDMIHDAQMDY-----YGTRLATCSSDRSV--------KIFDVRNGGQILIADLRGHEGP 59 ED +H + + G +A ++ V + DV + H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFH-HGVR 74 Query: 60 VWQVAWAHPMYGNIL------ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP 113 V +AW+ + L + + D K+ ++ + + GH +N + + P Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDP 134 Query: 114 HDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCN---AVSWAPAVVPGSLIDQ 170 + I A S D + G + AH + + +V W P ++ + Sbjct: 135 KEGQEI-ASVSDDHTCRIWNLEG--------VQTAHFVLHSPGMSVCWHPEETFKLMVAE 185 Query: 171 PSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTST 230 +G I+ + + LE+ + W + Sbjct: 186 KNG----------------TIRFYDLLAQ---QAILSLESEQVPLMSAHWC--LKNTFKV 224 Query: 231 IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWS-ITANILAVSGGDNK 285 A D IW +S + D WS I+ N+ A +G K Sbjct: 225 GAVAGND--WLIWDITRSSYPQNKRPV---HMDRACLFRWSTISENLFATTGYPGK 275 Score = 53.3 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 58/187 (31%), Gaps = 24/187 (12%) Query: 11 SHEDMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 H D I+ D G +A+ S D + +I+++ + A H P V W HP Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEG---VQTAHFVLHS-PGMSVCW-HPE 176 Query: 70 YGNILASCSYDRKVIIWKE------ENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 L + + + + E+ S H W + + A Sbjct: 177 ETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH--------WCLKNTFKVGAVA 228 Query: 124 SSDGAIS-LLTYTGEGQWEVKKINNAHTIGCNAVS---WAPAVVPGSLIDQPSGQKPNYI 179 +D I + + ++ A + +S +A PG + Q + Sbjct: 229 GNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHP 288 Query: 180 KKFASGG 186 + G Sbjct: 289 QPILMGS 295 >5WLC-LS nrPDB Length = 594 Score = 58.7 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 55/357 (15%), Positives = 98/357 (27%), Gaps = 74/357 (20%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 N SH I L T D++++I+ + L+ L P+ Sbjct: 241 ANASHPSHS-AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCT 299 Query: 65 WAH---PMYGNILASCSYDRKVIIWKE--------ENGTWEKTHEHSGHDS--------- 104 + + + R + W + EK GH+S Sbjct: 300 FYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFK 359 Query: 105 ----------SVNSVCWAPHDYGLILACGSSDGA----ISLLTYTGEGQWEVKKINNA-- 148 SV+ + + G I S+ G + + + + I+ Sbjct: 360 VAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKF 419 Query: 149 ------------------HTIGCNAVSWAPAVVPGSLIDQPSG-----------QKPNYI 179 + G W G Q G K Sbjct: 420 RTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQN 479 Query: 180 KKFASGGCDNLIKLWREEE---DGQWKEEQKLEAHSDWVRDVAWAPSIG-LPTSTIASCS 235 + A G + L+ L+ + + ++ ++P L ++ A Sbjct: 480 RWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKD 539 Query: 236 QDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 V + +C S S L K V V++S + +LAV KV LWK + Sbjct: 540 ALRLVHLPSCSVFSNWPTSGTPLGK----VTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 >5M89-A nrPDB Length = 329 Score = 56.0 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 42/213 (19%), Positives = 77/213 (36%), Gaps = 37/213 (17%) Query: 23 YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRK 82 + GT++ ++ VK++D A + H GPV +A HP G ILAS D+ Sbjct: 100 WTGTKVVIGTAKGWVKVYDAGRES----ATFQTHAGPVTGLA-VHPG-GRILASVGVDKS 153 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 + + E G E+ D+++ + + P G + A G+ G I + T Q E Sbjct: 154 FVFYDLETG--ERVARGYA-DAALTTCAFHPD--GNLFAAGTQTGHILVFHTTTLEQAE- 207 Query: 143 KKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQW 202 P Q N A+G + + ++ + G Sbjct: 208 -------------------SFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAA 248 Query: 203 KEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCS 235 ++L+ + V ++W +A+ Sbjct: 249 AAVKELQ--TGEVLSISWD----YTGQYLATGG 275 Score = 42.5 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 23/182 (12%), Positives = 61/182 (33%), Gaps = 13/182 (7%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 H + + G LA+ D+S +D+ G ++ + + A+ G Sbjct: 129 HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA---DAALTTCAFHPD--G 183 Query: 72 NILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 N+ A+ + ++++ ++ + + ++ ++ + + A G ++++ Sbjct: 184 NLFAAGTQTGHILVFHTTTLEQAESFPLG---TPIQALAFSENGF-WFAATGKGTSSVTI 239 Query: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLI 191 G K T ++SW + Y K A+ + Sbjct: 240 FDLRKSGAAAAVKEL--QTGEVLSISWDYTGQYLATGGGTGVTVQMYTK--ATKSWSEPV 295 Query: 192 KL 193 +L Sbjct: 296 RL 297 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 13/100 (13%), Positives = 29/100 (29%), Gaps = 10/100 (10%) Query: 190 LIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 K W + D +E + H+ V +A P +AS D + + Sbjct: 109 TAKGWVKVYDA-GRESATFQTHAGPVTGLAVHPG----GRILASVGVDKSFVFYDLETGE 163 Query: 250 GNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 + + ++ N+ A + ++ Sbjct: 164 RVARGYA-----DAALTTCAFHPDGNLFAAGTQTGHILVF 198 Score = 32.5 bits (72), Expect = 0.25, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 67/232 (28%), Gaps = 46/232 (19%) Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 A D K+ I+ E+T + V + W G + G++ G + + Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIG---EPVTATEWT----GTKVVIGTAKGWVKVYDA 119 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYI-------KKFASGGC 187 E + + G AV PG I G +++ ++ A G Sbjct: 120 GRESA--TFQTHAGPVTGL-------AVHPGGRILASVGVDKSFVFYDLETGERVARGYA 170 Query: 188 DNLIKLWREEEDGQWKEEQKLEAH-----------------SDWVRDVAWAPSIGLPTST 230 D + DG H ++ +A++ + Sbjct: 171 DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENG---FWF 227 Query: 231 IASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGG 282 A+ V I+ + +L V +SW T LA GG Sbjct: 228 AATGKGTSSVTIFDLRKSGAAAAVKELQTG---EVLSISWDYTGQYLATGGG 276 Score = 29.0 bits (63), Expect = 2.5, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 33/108 (30%), Gaps = 16/108 (14%) Query: 183 ASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 A GG D + ++ + K E+ L+ + V W + + + G V + Sbjct: 67 AVGGLDGKLDIYSVVAN---KVERTLD-IGEPVTATEW------TGTKVVIGTAKGWVKV 116 Query: 243 WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + S V ++ ILA G D + Sbjct: 117 YDAGRESA------TFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYD 158 >5TF2-A nrPDB Length = 407 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 74/216 (34%), Gaps = 12/216 (5%) Query: 19 AQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS 78 ++ T LAT +D V+++ V + ++L + HEG + +A L + Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLE--FKAHEGEIEDLALGPDGK---LVTVG 232 Query: 79 YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEG 138 D K +W+++ + + +G S + +G + + L T Sbjct: 233 RDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQV---PDQPAGLRLFTVQIP- 288 Query: 139 QWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFAS-GGCDNLIKLWREE 197 +++ + + ++ P + S + F G + ++ Sbjct: 289 HKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAF 348 Query: 198 EDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIAS 233 + EAH V DVA+ P G + S Sbjct: 349 SLQCLYYVR--EAHGIVVTDVAFLPEKGRGPELLGS 382 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 22/64 (34%), Gaps = 5/64 (7%) Query: 227 PTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 + +A+ DG V +W ++ + ++ L G D K Sbjct: 183 DNTLLATGGTDGYVRVWKV----PSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKA 237 Query: 287 TLWK 290 ++W+ Sbjct: 238 SVWQ 241 Score = 37.1 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 17/113 (15%), Positives = 39/113 (34%), Gaps = 9/113 (7%) Query: 134 YTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKL 193 E + + + + + A S Q + A+GG D +++ Sbjct: 140 APAEKKCGAETQHEGLELRVENL-QAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRV 198 Query: 194 WREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 W+ ++ + +AH + D+A P + + +D + +W D Sbjct: 199 WKVPS---LEKVLEFKAHEGEIEDLALGPDGK-----LVTVGRDLKASVWQKD 243 Score = 33.7 bits (75), Expect = 0.10, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 19/49 (38%), Gaps = 3/49 (6%) Query: 262 NDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 310 + + V ++ +LA G D V +WK + + +G + Sbjct: 172 DPLQKVVCFNHDNTLLATGGTDGYVRVWKVP---SLEKVLEFKAHEGEI 217 >3I2N-A nrPDB Length = 357 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 35/272 (12%), Positives = 75/272 (27%), Gaps = 59/272 (21%) Query: 26 TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNI----LASCSYDR 81 LAT ++ I+++ + + ++GH+ + + + + + S D Sbjct: 81 RYLATGDFGGNLHIWNLEAPE-MPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDG 139 Query: 82 KVIIWKEEN-----GTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTG 136 V +W E + D + A + ++ G +G I L Sbjct: 140 TVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRN 199 Query: 137 EG-QWEVKKINNAHTI-------GCNAVS---------------WAPAVVPGSLIDQPS- 172 +WE N ++ N + P S+ ++ Sbjct: 200 MALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHK 259 Query: 173 ------GQKPNYIKKFASGGCDNLIKLWREE---EDGQWKEEQKLEAH------------ 211 P + F + G + LW+ E + + E Sbjct: 260 STVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTL 319 Query: 212 -SDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 + + + W+P S D V + Sbjct: 320 STQPISSLDWSPDKRG---LCVCSSFDQTVRV 348 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 31/207 (14%), Positives = 63/207 (30%), Gaps = 31/207 (14%) Query: 97 HEHSGHDSSVNSVCWAPHDYGLI----LACGSSDGAISLLTYTGEGQWEVKKINNAHTIG 152 H G + +V W P + A G G I L +++I A I Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARG--TGVIQLYEIQHGDLKLLREIEKAKPIK 69 Query: 153 CNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHS 212 C G + A+G + +W E ++ H Sbjct: 70 CGTF----------------GATSLQQRYLATGDFGGNLHIWNLEAPEM--PVYSVKGHK 111 Query: 213 DWVRDVAWAPSIGLPTST--IASCSQDGRVFIWTCDDASGNMWSPKLLHKFN-DVVWHVS 269 + + + +G+ I + S+DG V +W + + + + N W V+ Sbjct: 112 EIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVA 171 Query: 270 W----SITANILAVSGGDNKVTLWKES 292 + + ++ + + L+ Sbjct: 172 FGNAYNQEERVVCAGYDNGDIKLFDLR 198 Score = 28.6 bits (62), Expect = 3.5, Method: Composition-based stats. Identities = 12/75 (16%), Positives = 22/75 (29%), Gaps = 3/75 (4%) Query: 225 GLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLH---KFNDVVWHVSWSITANILAVSG 281 L +A+ G + IW + ++S K D + + A + Sbjct: 77 SLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 282 GDNKVTLWKESVDGQ 296 D V +W Sbjct: 137 RDGTVKVWDPRQKDD 151 >5WLC-LH nrPDB Length = 896 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 38/354 (10%), Positives = 106/354 (29%), Gaps = 70/354 (19%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR---------GHEGPVWQ 62 H D + + G+ L + ++ + ++ + Q + L G +G + Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYS 355 Query: 63 VAW------AHPMYGNILASCS--------------YDRKVI----------------IW 86 + ++ Y +L + S ++ + I Sbjct: 356 LILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSIT 415 Query: 87 KEENGTWEKTHEH--SGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 + +++ + S +V P + L S+ + + + Q + Sbjct: 416 SLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISA---VQIFDFYKNEQVNYQY 472 Query: 145 INNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNY----------IKKFASGGCDNLIKLW 194 + + V + + + D + + +S +++K W Sbjct: 473 LTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFW 532 Query: 195 --REEEDGQWKEEQKLEAH--SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG 250 + E + + + H S + + +P + + +G + W+ D Sbjct: 533 TKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHES 592 Query: 251 NMWSPKLLH----KFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300 N W K + ++WS +++ G D+K+ + ++ + Sbjct: 593 N-WCLKKISLPNFNHFSNSVSLAWSQDGSLI-FHGFDDKLQILDFDTFKKFESL 644 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 39/89 (43%), Gaps = 5/89 (5%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 + +D G +LA + + I + + + I L+ H V ++++H G+ Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLAD---LQIRLLKWHIDSVLSLSFSHD--GS 310 Query: 73 ILASCSYDRKVIIWKEENGTWEKTHEHSG 101 L S +++ + +W+ E + + +G Sbjct: 311 YLLSGGWEKVMSLWQLETNSQQFLPRLNG 339 Score = 33.7 bits (75), Expect = 0.10, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 18/37 (48%) Query: 254 SPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 +LL D V +S+S + L G + ++LW+ Sbjct: 289 QIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQ 325 >6IYY-A nrPDB Length = 317 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 49/135 (36%), Gaps = 4/135 (2%) Query: 10 TSHEDMIHDAQMDYYGTRLATCSSDRS-VKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 +HE ++ ++ GTR+AT S + ++IFD +G I ++ + + Sbjct: 173 PAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQD 232 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTH-EHSGHDSSVNSVCWAPHDYGLILACGSSDG 127 +++ S V I+ E+ + + + S + +I C Sbjct: 233 --ASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSY 290 Query: 128 AISLLTYTGEGQWEV 142 L GE +V Sbjct: 291 YKFLFNPKGECIRDV 305 >3EI3-B nrPDB Length = 383 Score = 48.7 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 34/259 (13%), Positives = 76/259 (29%), Gaps = 32/259 (12%) Query: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 + V + W HP + +A S +I+W + + G ++ + + + Sbjct: 73 DRRVTSLEW-HPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNT 131 Query: 117 GLILACGSSDGAISLLTYTGE---------------GQWEVKKINNAHTIGCNAVSWAPA 161 + S GA +L ++G +V G + Sbjct: 132 NQLFVS-SIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLL 190 Query: 162 VVPGSLIDQPSGQKPNY---------IKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHS 212 + G I + K A+ D +KLW H Sbjct: 191 GLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHE 250 Query: 213 DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVW--HVSW 270 V + P+ ++ + + Q + +++ D S H+ + +W Sbjct: 251 KPVNAAYFNPT---DSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATW 307 Query: 271 SITANILAVSGG-DNKVTL 288 +++ D+++ L Sbjct: 308 HPMYDLIVAGRYPDDQLLL 326 Score = 34.4 bits (77), Expect = 0.063, Method: Composition-based stats. Identities = 40/212 (18%), Positives = 60/212 (28%), Gaps = 29/212 (13%) Query: 103 DSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAV 162 D V S+ W P +A GS G I L Y + N S+ + Sbjct: 73 DRRVTSLEWHPTH-PTTVAVGSKGGDIILWDYDVQ----------------NKTSFIQGM 115 Query: 163 VPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAP 222 PG I + N + F S I+ D Q W W Sbjct: 116 GPGDAITGMKFNQFNTNQLFVS-----SIRGATTLRDFSGSVIQVFAKTDSWDY---WYC 167 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL-AVSG 281 + + S + D + ++ KL V H ++ + L A S Sbjct: 168 CVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKL---HKAKVTHAEFNPRCDWLMATSS 224 Query: 282 GDNKVTLWKESVDGQWVCISDVNKGQGSVSAS 313 D V LW + V+A+ Sbjct: 225 VDATVKLWDLRNIKDKNSYIAEMPHEKPVNAA 256 Score = 29.0 bits (63), Expect = 2.5, Method: Composition-based stats. Identities = 12/73 (16%), Positives = 22/73 (30%), Gaps = 1/73 (1%) Query: 250 GNMWSPKLLHKFNDVVWHVSWSIT-ANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQG 308 + + F+ V + W T +AV + LW V + I + G Sbjct: 61 KSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDA 120 Query: 309 SVSASITEGQQNE 321 + N+ Sbjct: 121 ITGMKFNQFNTNQ 133 >3DW8-B nrPDB Length = 447 Score = 48.3 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 45/326 (13%), Positives = 91/326 (27%), Gaps = 69/326 (21%) Query: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 D + D+I + ++ G LAT V IF +I RG E V+ +H Sbjct: 24 DVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHS-RG-EYNVYSTFQSHE 81 Query: 69 MYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGA 128 + L S + +N + W P ++D Sbjct: 82 PEFDYLKS-----------------------LEIEEKINKIRWLPQKNAAQFLLSTNDKT 118 Query: 129 ISLLTYTGEGQ------WEVKKINNAHTIGCNAVSWAPAVVPGSLIDQP----------- 171 I L + + + + + P P L+ + Sbjct: 119 IKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLR-VPVFRPMDLMVEASPRRIFANAHT 177 Query: 172 ----SGQKPNYIKKFASGGCDNLIKLWREEEDGQ-----WKEEQKLEAHSDWVRDVAWAP 222 S + + + S D I LW E + + +E ++ + + P Sbjct: 178 YHINSISINSDYETYLSAD-DLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHP 236 Query: 223 SIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDV------------VWHVSW 270 + S G + + ++ KL + D + V + Sbjct: 237 NSCNTFVY---SSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKF 293 Query: 271 SITANILAVSGGDNKVTLWKESVDGQ 296 S + + V +W +++ + Sbjct: 294 SHSGRYMMTRDY-LSVKVWDLNMENR 318 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 36/367 (9%), Positives = 99/367 (26%), Gaps = 97/367 (26%) Query: 13 EDMIHDAQMDY--YGTRLATCSSDRSVKIF-----------------DVRNGGQILIADL 53 E+ I+ + + ++D+++K++ D R + L Sbjct: 93 EEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTL 152 Query: 54 R---------------------GHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEE--N 90 R H + ++ + + D ++ +W E + Sbjct: 153 RVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYL---SADDLRINLWHLEITD 209 Query: 91 GTWEKTHEHSGHDSSVNSV----CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 ++ + + V + P+ + S G I L + Sbjct: 210 RSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSK-GTIRLCDMRASALCDRHSKL 268 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 + S+ + + + + + +K+W + + + Sbjct: 269 FEEPEDPSNRSF----FSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENR--PVE 321 Query: 207 KLEAHSDWVRDV-----------AWAPSIGLPTSTIASCSQDGRVFIWTCDD-------- 247 + H + + S + + S + ++ + Sbjct: 322 TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEA 381 Query: 248 ASGNMWSPKLLH--------------------KFNDVVWHVSWSITANILAVSGGDNKVT 287 + N +L FN + H +W NI+AV+ +N + Sbjct: 382 SRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN-LY 440 Query: 288 LWKESVD 294 ++++ V+ Sbjct: 441 IFQDKVN 447 >5MC6-j nrPDB Length = 397 Score = 47.9 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 41/321 (12%), Positives = 106/321 (33%), Gaps = 36/321 (11%) Query: 1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR-----NGGQILIADLRG 55 + +H+ I + + +CS D +K++D + N + Sbjct: 4 VFIATANAGKAHDADI--FSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFV- 60 Query: 56 HEGPVWQVAWAHPMYGN-----ILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVC 110 H+ + V + + ++A+ S+ ++ ++ K + Sbjct: 61 HKSGLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFE--KLDLLDSD 118 Query: 111 WAPHDYGLILACGSSDGAI--SLLTYTGEGQWEVKKINN-AHTIGCNAVSWAPAVVPGSL 167 H + + S+D + L+ +G + K + A ++W+P + Sbjct: 119 MKKHSFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGT 178 Query: 168 IDQPSGQKP-------NYIKKFASGGCDNLIKLWREEEDG---QWKEEQKLEAHSDWVRD 217 ++ P + A+G + +++ ++ + + +S+ +R Sbjct: 179 VESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRS 238 Query: 218 VAWAPSIGLPTSTIASCSQDG-RVFIWTCDDASGNMWSPKLLH-------KFNDVVWHVS 269 V ++P L S S ++ + G++ P + V +S Sbjct: 239 VKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLS 298 Query: 270 WSITANILAVSGGDNKVTLWK 290 ++ + L +G D K+ W Sbjct: 299 FNDSGETLCSAGWDGKLRFWD 319 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 36/108 (33%), Gaps = 18/108 (16%) Query: 13 EDMIHDAQMDYYGTRLATCSSDRS---VKIFDVRNGGQI-----LIADLRG------HEG 58 + I + G+ LA S + +++ G +I + H Sbjct: 233 SNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSS 292 Query: 59 PVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSV 106 V +++ G L S +D K+ W + T E+ + H + Sbjct: 293 WVMSLSFN--DSGETLCSAGWDGKLRFWDVK--TKERITTLNMHCDDI 336 Score = 40.2 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 69/239 (28%), Gaps = 39/239 (16%) Query: 49 LIADLRGHEGPVWQVAWAHPMY---GNILASCSYDRKVIIW---------KEENGTWEKT 96 L +D++ H W + W + L + IW W T Sbjct: 115 LDSDMKKHS--FWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPT 172 Query: 97 HEHSG-------HDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW---EVKKIN 146 E G SV + + GLI A G ++G + + + E + Sbjct: 173 LELQGTVESPMTPSQFATSVDIS--ERGLI-ATGFNNGTVQISELSTLRPLYNFESQHSM 229 Query: 147 NAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQ 206 ++ +V ++P GSL+ I Sbjct: 230 INNSNSIRSVKFSPQ---GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLG 286 Query: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVV 265 + AHS WV +++ S T+ S DG++ W L+ D + Sbjct: 287 EF-AHSSWVMSLSFNDS----GETLCSAGWDGKLRFWDVKTKER----ITTLNMHCDDI 336 Score = 32.1 bits (71), Expect = 0.30, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 19/50 (38%), Gaps = 2/50 (4%) Query: 11 SHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV 60 +H + + G L + D ++ +DV+ + I L H + Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKT--KERITTLNMHCDDI 336 >2I3T-A nrPDB Length = 341 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 51/308 (16%), Positives = 98/308 (31%), Gaps = 39/308 (12%) Query: 13 EDMIHDAQMDYYGTRLATCSSDR--SVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 +D I D ++ + L S D +V FD++ L+ LR ++ P+ + Sbjct: 11 KDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFIDNTD 69 Query: 71 GNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 I + +++ + ++ + + +C L S DG I Sbjct: 70 LQIYV-GTVQGEILKVDLIGSPSFQALTNNEANLGICRIC---KYGDDKLIAASWDGLIE 125 Query: 131 LLTYT--GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188 ++ G+G VK +N+ +T N + + G + Sbjct: 126 VIDPRNYGDGVIAVKNLNSNNTKVKNKI----------------FTMDTNSSRLIVGMNN 169 Query: 189 NLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 + ++ +R + +RDVA P A S DGRV + DD Sbjct: 170 SQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLP---KEQEGYACSSIDGRVAVEFFDDQ 226 Query: 249 SGNMWSPKLL-----------HKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQW 297 + S K V + +S L +G D ++ W + Sbjct: 227 GDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKI 286 Query: 298 VCISDVNK 305 + N+ Sbjct: 287 KNFAKFNE 294 >6CVZ-A nrPDB Length = 351 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 68/255 (26%), Gaps = 38/255 (14%) Query: 56 HEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHD 115 H + +A++ + G +L S S D + + E T +T+ V S CW + Sbjct: 73 HGKQIRGLAFSSYLRG-LLLSASLDNTIKLTSLETNTVVQTYNAG---RPVWSCCWCLDE 128 Query: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQK 175 I A G ++G+I + + + ++S+ P + Sbjct: 129 ANYIYA-GLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAG 187 Query: 176 PNYIKKFASGGCDNLIKLWRE-------------EEDGQWKEEQKLEAHSD--WVRDVAW 220 F D W E+ + +R V Sbjct: 188 TLEDASFWEQKMD--FSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLM 245 Query: 221 APSIGLP--TSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILA 278 S L + I SC F F NIL Sbjct: 246 EMSYRLDDTGNPICSCQPVHTFF------GGPTCKLLTKNAIFQSP------ENDGNILV 293 Query: 279 VSGGD--NKVTLWKE 291 +G + N LW Sbjct: 294 CTGDEAANSALLWDA 308 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 13/80 (16%), Positives = 27/80 (33%), Gaps = 5/80 (6%) Query: 12 HEDMIHDAQMDYYGT-RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H I Y L + S D ++K+ + ++ PVW W Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETN--TVVQTYNA-GRPVWSCCWCLDEA 129 Query: 71 GNILASCSYDRKVIIWKEEN 90 N + + + ++++ N Sbjct: 130 -NYIYAGLANGSILVYDVRN 148 >5WLC-LW nrPDB Length = 554 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 40/122 (32%), Gaps = 8/122 (6%) Query: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNIL 74 Y L T +K DV G L+++LR GP +A A + ++ Sbjct: 192 EARHLDFLPYHYLLVTAGETGWLKYHDVSTGQ--LVSELRTKAGP--TMAMAQNPWNAVM 247 Query: 75 ASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 + V +W E + VNS+ G +A +D ++ + Sbjct: 248 HLGHSNGTVSLWSPS--MPEPLVKLLSARGPVNSIAI--DRSGYYMATTGADRSMKIWDI 303 Query: 135 TG 136 Sbjct: 304 RN 305 Score = 41.4 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 21/33 (63%) Query: 15 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ 47 ++ +D G +AT +DRS+KI+D+RN Q Sbjct: 276 PVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQ 308 Score = 36.0 bits (81), Expect = 0.023, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 4/62 (6%) Query: 31 CSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEEN 90 S+ +V ++ + L GPV +A G +A+ DR + IW N Sbjct: 250 GHSNGTVSLW--SPSMPEPLVKLLSARGPVNSIAI--DRSGYYMATTGADRSMKIWDIRN 305 Query: 91 GT 92 Sbjct: 306 FK 307 Score = 32.1 bits (71), Expect = 0.32, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 27/79 (34%), Gaps = 4/79 (5%) Query: 237 DGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 +G V +W+ + V ++ + +A +G D + +W Q Sbjct: 253 NGTVSLWSPSMPEPLVKLLSA----RGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQ 308 Query: 297 WVCISDVNKGQGSVSASIT 315 + + +VS S T Sbjct: 309 LHSVESLPTPGTNVSISDT 327 >3JB9-S nrPDB Length = 488 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 43/114 (37%), Gaps = 9/114 (7%) Query: 12 HEDMIHDAQMDYYGTRLA-TCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 H + Q G L T + D + I+D+R + L+ V + + Sbjct: 374 HSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAV-----SLDIT 428 Query: 71 GNILASC-SYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 +L S V I+ + + +W + H SS++++ W + L+ + Sbjct: 429 SQLLVSSDGETLYVHIYVKSSKSWRCMSQ--THVSSISNLVWLNELHQLLFSTS 480 >2VDU-B nrPDB Length = 450 Score = 41.4 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 34/93 (36%), Gaps = 7/93 (7%) Query: 11 SHEDMIHDAQM--DYYGTRLATCSS-DRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAH 67 H M+ D + D G + S D +KI I+ L GH+ V + Sbjct: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISH-YPQCFIVDKWLFGHKHFVSSICC-- 249 Query: 68 PMYGNILASCSYDRKVIIWKEENGTWEKTHEHS 100 +L S D K+ W + G T +++ Sbjct: 250 -GKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYN 281 Score = 36.0 bits (81), Expect = 0.020, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 55/179 (30%), Gaps = 22/179 (12%) Query: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPS 172 D ++AC SD ++ + + V K+ + + P ++ Sbjct: 111 TSDESRLIACADSDKSLLVFDVDKTSK-NVLKLRK---------RFCFSKRPNAISIAED 160 Query: 173 GQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 KF G I + E ++ +E L H + DV I Sbjct: 161 DTTVIIADKF---GDVYSIDINSIPE-EKFTQEPIL-GHVSMLTDVHLIKDSDG-HQFII 214 Query: 233 SCSQDGRVFIWTCDDASGNMWSP-KLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 + +D + I + K L V + +L +GGD+K+ W Sbjct: 215 TSDRDEHIKI----SHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWD 268 >4FHN-A nrPDB Length = 394 Score = 41.0 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 90/298 (30%), Gaps = 35/298 (11%) Query: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADL---RGHEGPVWQVAWA-- 66 H+ + Y LA D +V++ +N I L GH V + A Sbjct: 89 HDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADV 148 Query: 67 ----HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILAC 122 + + ++AS D +IIW+ + + SV + P + ++ Sbjct: 149 YSADNRLAEQVIASVGDDCTLIIWRL-TDEGPILAGYPLSSPGI-SVQFRPSNPNQLIV- 205 Query: 123 GSSDGAISLLTYT----GEGQWEVKKINNAHTIGCNAVSWAPA-VVPGSLIDQPSGQKPN 177 G +G I + +T E + + + N + N + G + + Sbjct: 206 GERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIG 265 Query: 178 YIKKFASGGCDNLIKL-WREEEDGQWKEEQKLEAHSDW------VRDVAWAPS------I 224 C + L W + + E V+ ++ PS Sbjct: 266 SDGSGILAMCKSGAWLRWNLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLGACPH 325 Query: 225 GLPTSTIASC-SQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSG 281 A+ SQ G + + + N +L + W + LA++ Sbjct: 326 PRYMDYFATAHSQHGLIQLINTYEKDSNSIPIQL----GMPIVDFCWHQDGSHLAIAT 379 Score = 36.4 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 40/115 (34%), Gaps = 7/115 (6%) Query: 188 DNLIK--LWREEEDGQWKEEQKLEAHSDWVRDVA----WAPSIGLPTSTIASCSQDGRVF 241 DN ++ + + E H ++V D+ ++ L IAS D + Sbjct: 111 DNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASVGDDCTLI 170 Query: 242 IWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 IW D + L V + S + I+ G+ ++ W ++ + Sbjct: 171 IWRLTDEGPILAGYPLSSPGISVQFRPS-NPNQLIVGERNGNIRIFDWTLNLSAE 224 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 15/89 (16%) Query: 9 DTSHEDMIHDA----QMDYYGTR----LATCSSDRSVKIFDVRNGGQILIADLRGH--EG 58 + H + ++D +A+ D ++ I+ + + G I L G+ Sbjct: 133 KSGHHNFVNDIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPI----LAGYPLSS 188 Query: 59 PVWQVAWAHPMYGNILASCSYDRKVIIWK 87 P V + P N L + + I+ Sbjct: 189 PGISVQF-RPSNPNQLIVGERNGNIRIFD 216 >4AV8-A nrPDB Length = 339 Score = 38.3 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 39/89 (43%), Gaps = 7/89 (7%) Query: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGR-VFIWTCDDASGNMWSPKLLHKFNDVVWH 267 +AH++ V+ V + +A+CSQDG + ++ D+ + L + + Sbjct: 176 KAHANPVKMVR----LNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDR--TSIID 229 Query: 268 VSWSITANILAVSGGDNKVTLWKESVDGQ 296 + WS + LAV + +++ D + Sbjct: 230 MRWSPDGSKLAVVSDKWTLHVFEVFNDAE 258 Score = 36.4 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 53/127 (41%), Gaps = 10/127 (7%) Query: 8 VDTSHEDMIHDAQMDYYGTRLATCSSDRS-VKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 + +H + + +++ G +ATCS D + +++F NG + + + W+ Sbjct: 174 LVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS 233 Query: 67 HPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVN----SVCWAPHDYGLILAC 122 G+ LA S + +++ N K H +N W+ ++ L ++ Sbjct: 234 PD--GSKLAVVSDKWTLHVFEVFNDAENKRHVL---KDWINIKYFQSEWSICNFKLKVSK 288 Query: 123 GSSDGAI 129 GS+D I Sbjct: 289 GSNDCKI 295 >5LTD-A nrPDB Length = 525 Score = 37.5 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 30/178 (16%), Positives = 60/178 (33%), Gaps = 30/178 (16%) Query: 36 SVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCS----------------- 78 ++ I+D+ L+ + P +A + N LA S Sbjct: 138 TIYIYDI--NNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSN 195 Query: 79 ----YDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTY 134 + VII+ + T + T H +S+ ++ + GL+LA S G I + Sbjct: 196 PQTVRNGDVIIFDAK--TLQPTSVIEAHRTSLAAIALSKD--GLLLATASDKGTIIRVFS 251 Query: 135 TGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIK 192 G + + +++++P + S + +I + N IK Sbjct: 252 VATGIKLYQFRRGTYPTKIYSLAFSP---DNRFVIASSATETVHIFRLGEEEAANTIK 306 Score = 35.6 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 32/80 (40%), Gaps = 3/80 (3%) Query: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRS-VKIFDVRNGGQILIADLRGHEGPVWQVAW 65 +V +H + + G LAT S + +++F V G ++ + ++ +A+ Sbjct: 216 SVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAF 275 Query: 66 AHPMYGNILASCSYDRKVII 85 + + + S V I Sbjct: 276 SPD--NRFVIASSATETVHI 293 >4YHC-A nrPDB Length = 468 Score = 37.5 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 41/109 (37%), Gaps = 3/109 (2%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 I V H+ I + A+ DRS+ ++D+R L+ + +A Sbjct: 22 IEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIA 81 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP 113 GN ++ S D + I E+ + H + +S +V W P Sbjct: 82 L--DPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 Score = 31.3 bits (69), Expect = 0.55, Method: Composition-based stats. Identities = 11/85 (12%), Positives = 29/85 (34%), Gaps = 6/85 (7%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 + +++ E H + +A + + T AS D + +W + K Sbjct: 17 EEKFRIEPVPVHHQLDILKIAVSEN----YKTFASVGLDRSLVVWDLRQWCTKLVLSK-- 70 Query: 259 HKFNDVVWHVSWSITANILAVSGGD 283 + + ++ N +++ D Sbjct: 71 EQMPRTLKAIALDPQGNYVSLFSKD 95 >5GRS-A nrPDB Length = 396 Score = 36.7 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 40/109 (36%), Gaps = 3/109 (2%) Query: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 I V H+ I + A+ DR + ++D+R L+ + +A Sbjct: 22 IEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIA 81 Query: 65 WAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP 113 GN ++ S D + I E+ + H + +S +V W P Sbjct: 82 L--DPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMP 127 Score = 30.6 bits (67), Expect = 0.87, Method: Composition-based stats. Identities = 11/85 (12%), Positives = 29/85 (34%), Gaps = 6/85 (7%) Query: 199 DGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 + +++ E H + +A + + T AS D + +W + K Sbjct: 17 EEKFRIEPVPVHHQLDILKIAVSEN----YKTFASVGLDRCLVVWDLRQWCTKLVLSK-- 70 Query: 259 HKFNDVVWHVSWSITANILAVSGGD 283 + + ++ N +++ D Sbjct: 71 EQMPRTLKAIALDPQGNYVSLFSKD 95 >6N8P-A nrPDB Length = 979 Score = 34.4 bits (77), Expect = 0.060, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 84/296 (28%), Gaps = 48/296 (16%) Query: 14 DMIHDAQMDY-YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN 72 +M+ Q ++ S V I+D+ G ++L L + + W G Sbjct: 178 EMVEALQEHPRDPNQILIGYSRGLVVIWDL-QGSRVLYHFLS--SQQLENIWWQRD--GR 232 Query: 73 ILASCSYDRKVIIW----KEENGTWEKTHEHSG--HDSSVNSVCWAPHDYGL---ILACG 123 +L SC D W + + ++ G ++ + W GL I G Sbjct: 233 LLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGG 292 Query: 124 SSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFA 183 + + + + I++ + S + D + Y Sbjct: 293 -------MPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYA--LV 343 Query: 184 SGGCDNLIKLWREEEDGQWKEEQKLEA--HSDWVRDVAWAPSI--GLPTSTIASCSQDGR 239 + L+ + + G + A H + +I L IA+ S+ Sbjct: 344 VLAEEELVVI-DLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNA 402 Query: 240 VFI---WTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 F W D + +P ++L D V W S Sbjct: 403 HFSTMEWPIDGGTSLTPAP----------------PQRDLLLTGHEDGTVRFWDAS 442 Score = 32.5 bits (72), Expect = 0.22, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 31/94 (32%), Gaps = 10/94 (10%) Query: 30 TCSSDRS---VKIFD-VRNGGQILIADLRGHEGPV---WQVAWAHPMYGNILASCSYDRK 82 TCS S +K+++ + G A E P+ + A P +L + D Sbjct: 377 TCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRD-LLLTGHEDGT 435 Query: 83 VIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDY 116 V W ++ S V P++ Sbjct: 436 VRFWDASGVCLRLLYKLS--TVRVFLTDTDPNEN 467 >5CWW-B nrPDB Length = 595 Score = 32.9 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 27/97 (27%), Gaps = 11/97 (11%) Query: 212 SDWVRDVAWAPS------IGLPTSTIASCSQDGRVFIWTCDDASGNMW--SPKLLHKFND 263 +D +R + +P+ + T I + I W P Sbjct: 114 ADDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRS 173 Query: 264 VVWHVSWSI---TANILAVSGGDNKVTLWKESVDGQW 297 V W + L D V +W+ S +W Sbjct: 174 AVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRW 210 Score = 30.6 bits (67), Expect = 0.97, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 16/44 (36%), Gaps = 1/44 (2%) Query: 98 EHSGHDSSVNSVCWAP-HDYGLILACGSSDGAISLLTYTGEGQW 140 H S+V S W P G L + D + + + +W Sbjct: 167 THVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRW 210 Score = 29.8 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 9/47 (19%), Positives = 17/47 (36%), Gaps = 1/47 (2%) Query: 212 SDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLL 258 V W P +G+ + + ++D V +W A + L Sbjct: 172 RSAVVSAVWHP-LGVNGHALVTVTEDAIVRVWELSTADRWTFDAPTL 217 Score = 28.3 bits (61), Expect = 4.3, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 14/36 (38%), Gaps = 3/36 (8%) Query: 16 IHDAQMDY---YGTRLATCSSDRSVKIFDVRNGGQI 48 + A G L T + D V+++++ + Sbjct: 175 VVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRW 210 >4MHC-A nrPDB Length = 826 Score = 32.1 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 42/117 (35%), Gaps = 10/117 (8%) Query: 186 GCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPS---IGLPTSTIASCSQDGRVFI 242 DN + LW ++ ++E V+ V +P+ + I + D + Sbjct: 108 TSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILT 167 Query: 243 --WTCDDASGNMWSPKL---LHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVD 294 + N+++ L + FN V +S+ T I D V +W+ + Sbjct: 168 ISFNDRTHELNIFNTGLKVNVTGFN-VSNIISYERTGQIFFTGATDG-VNVWELQYN 222 >1NDS-A nrPDB Length = 330 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 29/73 (39%), Gaps = 2/73 (2%) Query: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 V+V+ T+ SH + + A G T + SV I + + GH VW Sbjct: 197 VAVMRTLTPSHA-VFNGAVGALTGANALTAAVGESVLIIHSQANRDSRPHLIGGHGDWVW 255 Query: 62 QV-AWAHPMYGNI 73 +A+P N+ Sbjct: 256 TTGKFANPPQLNM 268 >1OI2-A nrPDB Length = 366 Score = 29.8 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 7/25 (28%), Positives = 14/25 (56%) Query: 70 YGNILASCSYDRKVIIWKEENGTWE 94 + +L + SY R + W + G+W+ Sbjct: 249 FDTLLVNGSYHRTLRFWDYQQGSWQ 273 >3O9P-A nrPDB Length = 519 Score = 29.4 bits (64), Expect = 2.1, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 25/80 (31%), Gaps = 4/80 (5%) Query: 30 TCSSDRSVKIF--DVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWK 87 T + D + D L H G + + + +P Y +LA S + V Sbjct: 408 TGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISR--FNNPAYDKVLAQASTENTVKARN 465 Query: 88 EENGTWEKTHEHSGHDSSVN 107 + EK + + Sbjct: 466 ADYNAAEKILMEQAPIAPIY 485 >5BPT-A nrPDB Length = 741 Score = 29.0 bits (63), Expect = 2.5, Method: Composition-based stats. Identities = 18/74 (24%), Positives = 27/74 (36%), Gaps = 6/74 (8%) Query: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANIL 277 +AW+P IA ++ G V + + +WS V ++W IL Sbjct: 19 LAWSP----KRDLIALVNKAGEVLLHRLANIQ-RVWSLPPNENTGKEVTCLAWRPDGKIL 73 Query: 278 AVSGGD-NKVTLWK 290 A D KV L Sbjct: 74 AFGLADTKKVILCD 87 >5TXC-A nrPDB Length = 705 Score = 29.0 bits (63), Expect = 2.6, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 15/29 (51%), Gaps = 1/29 (3%) Query: 269 SWSITANILAVSGGD-NKVTLWKESVDGQ 296 WS + LA D +V +W+ SV G+ Sbjct: 133 RWSPSGTHLAYLRQDQGRVRVWRASVKGE 161 >6DKH-A nrPDB Length = 346 Score = 28.6 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 21/38 (55%) Query: 86 WKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACG 123 WK E G ++ + E SGH SSVN+ G+++ G Sbjct: 232 WKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVG 269 >1RI6-A nrPDB Length = 343 Score = 27.5 bits (59), Expect = 7.7, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 48/168 (28%), Gaps = 22/168 (13%) Query: 111 WAPHDYGLILACGSSD-GAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169 + G + GS + G +S+ V + +A + P + Sbjct: 89 ISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSA-----NISPDNRTL 143 Query: 170 QPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTS 229 K + I F +L+ E +E R + + P+ Sbjct: 144 WVPALKQDRICLFTVSDDGHLVA-------QDPAEVTTVEG--AGPRHMVFHPNEQYAYC 194 Query: 230 TIASCSQDGRVFIWTCDDASGNMWSPKLLH----KFNDVVWHVSWSIT 273 + V +W D GN+ + L F+D W IT Sbjct: 195 V---NELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHIT 239 >4XXF-A nrPDB Length = 258 Score = 27.5 bits (59), Expect = 8.6, Method: Composition-based stats. Identities = 7/56 (12%), Positives = 24/56 (42%) Query: 261 FNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITE 316 + + ++S LA++ D+ ++ G + + K G+++ ++ + Sbjct: 117 HSHSTYGKAFSSLGKPLAITTQDSCAFYGDVALLGDFGGVVIEEKESGTIAVALQQ 172 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.120 0.327 Lambda K H 0.267 0.0368 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,845,526 Number of Sequences: 36641 Number of extensions: 504003 Number of successful extensions: 5278 Number of sequences better than 10.0: 154 Number of HSP's better than 10.0 without gapping: 174 Number of HSP's successfully gapped in prelim test: 83 Number of HSP's that attempted gapping in prelim test: 1335 Number of HSP's gapped (non-prelim): 1047 length of query: 322 length of database: 10,336,785 effective HSP length: 97 effective length of query: 225 effective length of database: 6,782,608 effective search space: 1526086800 effective search space used: 1526086800 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.5 bits)