BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q46857 (275 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1MZR-A nrPDB 564 e-161 1A80-A nrPDB 273 5e-74 4OTK-A nrPDB 260 5e-70 4GIE-A nrPDB 254 4e-68 4F40-A nrPDB 240 5e-64 1VBJ-A nrPDB 238 2e-63 1VP5-A nrPDB 236 1e-62 3D3F-A nrPDB 232 1e-61 4MHB-A nrPDB 213 9e-56 3WCZ-A nrPDB 207 6e-54 2ALR-A nrPDB 199 9e-52 1HQT-A nrPDB 197 6e-51 4GAC-A nrPDB 194 4e-50 1ZUA-X nrPDB 193 6e-50 4HBK-A nrPDB 191 2e-49 3H7R-A nrPDB 187 3e-48 1QWK-A nrPDB 187 3e-48 3H7U-A nrPDB 186 7e-48 2BGQ-A nrPDB 185 1e-47 5JH1-A nrPDB 183 8e-47 5ZCM-A nrPDB 182 1e-46 1FRB-A nrPDB 177 4e-45 1C9W-A nrPDB 174 5e-44 5Z6T-A nrPDB 172 2e-43 1DLA-A nrPDB 172 2e-43 4JQA-A nrPDB 171 3e-43 1K8C-A nrPDB 171 3e-43 5UXF-A nrPDB 168 2e-42 1Q5M-A nrPDB 167 3e-42 3KRB-A nrPDB 167 5e-42 3RX4-A nrPDB 166 8e-42 3G1R-A nrPDB 165 2e-41 3O3R-A nrPDB 164 5e-41 5JM5-A nrPDB 163 9e-41 4IJC-A nrPDB 157 4e-39 2FVL-A nrPDB 155 2e-38 1AFS-A nrPDB 154 3e-38 2HE8-A nrPDB 152 2e-37 3WG6-A nrPDB 150 8e-37 4H8N-A nrPDB 146 8e-36 3UP8-A nrPDB 145 1e-35 1PZ1-A nrPDB 76 1e-14 1PYF-A nrPDB 69 2e-12 4R9O-A nrPDB 63 1e-10 1OG6-A nrPDB 60 1e-09 1LQA-A nrPDB 54 6e-08 3EB3-A nrPDB 47 7e-06 4EXA-A nrPDB 44 9e-05 3N6Q-A nrPDB 41 7e-04 1GVE-A nrPDB 35 0.044 2CLP-A nrPDB 34 0.063 2C91-A nrPDB 34 0.064 2BP1-A nrPDB 34 0.076 3T6Z-A nrPDB 30 1.2 6MFL-A nrPDB 28 5.0 3VS9-A nrPDB 28 5.7 >1MZR-A nrPDB Length = 296 Score = 564 bits (1453), Expect = e-161, Method: Compositional matrix adjust. Identities = 274/275 (99%), Positives = 275/275 (100%) Query: 1 MANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 60 +ANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA Sbjct: 22 LANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 81 Query: 61 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 120 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW Sbjct: 82 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 141 Query: 121 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 180 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK Sbjct: 142 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 201 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE Sbjct: 202 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 261 Query: 241 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 275 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG Sbjct: 262 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 296 >1A80-A nrPDB Length = 277 Score = 273 bits (698), Expect = 5e-74, Method: Compositional matrix adjust. Identities = 139/274 (50%), Positives = 182/274 (66%), Gaps = 6/274 (2%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 P+++ L DGN +PQLG GV++ + A+++ALEVGYR IDTAA Y NEEGVG A+ Sbjct: 3 PSIV-LNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGVGAAIAA 61 Query: 64 ASVNREELFITTKLWNDDHK--RPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWK 121 + + R++LFITTKLWND H P A+ +SL KL LD +DLYL+HWP PA D+YV AW+ Sbjct: 62 SGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTPAADNYVHAWE 121 Query: 122 GMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKI 181 MIEL+ GL +SIGV N + HL+R++ TGV P +NQIELHP QQR++ W A H + Sbjct: 122 KMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPAVNQIELHPAYQQREITDWAAAHDV 181 Query: 182 QTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAEN 241 + ESW PL QG +F + + A +GKTPAQ V+RWHL G VV PKSV R+ EN Sbjct: 182 KIESWGPLGQGKYDLFGAEPVTAAAAAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEEN 241 Query: 242 FDVWDFRLDKDELGEIAKLDQGK---RLGPDPDQ 272 DV+DF L E+ I +D G R+ PD+ Sbjct: 242 LDVFDFDLTDTEIAAIDAMDPGDGSGRVSAHPDE 275 >4OTK-A nrPDB Length = 318 Score = 260 bits (664), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 129/271 (47%), Positives = 174/271 (64%), Gaps = 4/271 (1%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASV 66 I L D + MP LGLGV + S++E A+ ALE+G R IDTA AY NE VG+A+ + V Sbjct: 49 ITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIAASGV 108 Query: 67 NREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMI 124 REELF+TTKL D R +EA SL +L LDY+DLYL+HWP P + YV+AW GMI Sbjct: 109 AREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMI 168 Query: 125 ELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTE 184 + + EG +SIGV NF +++ LID T VTP +NQIELHPL+ Q +L NA H + T+ Sbjct: 169 QSRGEGHARSIGVSNFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQ 228 Query: 185 SWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDV 244 S+ PLA G + D + +A +Y KTPAQ+++RW+L G V+ +S P RIA NFDV Sbjct: 229 SYCPLALG--RLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDV 286 Query: 245 WDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 275 +DF L + + + L+ G R+ DP + G Sbjct: 287 FDFELAAEHMDALGGLNDGTRVREDPLTYAG 317 >4GIE-A nrPDB Length = 290 Score = 254 bits (648), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 123/276 (44%), Positives = 179/276 (64%), Gaps = 6/276 (2%) Query: 2 ANPTVIKLQDGNVMPQLGLGVWQASN-EEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 60 N + L + MPQLGLGVW+A + E A++ A+E GYR IDTA Y NE GVG+ Sbjct: 11 CNYNCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQG 70 Query: 61 LKNASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVE 118 ++ + V REE+++TTK+WN D +++ A S + L L+YIDLYL+HWP +V+ Sbjct: 71 IRESGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP--GKKKFVD 128 Query: 119 AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNAT 178 WK + +L +E +++IGV NF+ HHL L + P++NQ+ELHPL QQR L + Sbjct: 129 TWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMVNQVELHPLFQQRTLREFCKQ 188 Query: 179 HKIQTESWSPLAQGGK-GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSR 237 H I +WSPL G + G+ V+ ++A K+ K+PAQ+VIRW + G+V IPKS R Sbjct: 189 HNIAITAWSPLGSGEEAGILKNHVLGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGR 248 Query: 238 IAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 I ENF+VWDF+L ++E+ +I +L++ KR+G DPD F Sbjct: 249 IQENFNVWDFKLTEEEMRQIDELNEDKRIGADPDNF 284 >4F40-A nrPDB Length = 288 Score = 240 bits (612), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 122/277 (44%), Positives = 174/277 (62%), Gaps = 11/277 (3%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVI-TAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 ++ L +G MPQ GLGVWQ+ EV A++ AL GYR IDTAA YKNEE VG L+ Sbjct: 11 AMVTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRA 70 Query: 64 ASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWP------VPAIDH 115 + V RE++FITTKLWN + ++ A +S +KL +DYIDLYL+HWP Sbjct: 71 SGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEGKK 130 Query: 116 YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW 175 Y+++W+ +L KE +++IGV NF IHHL+ ++ VTP++NQ+ELHPL Q L A+ Sbjct: 131 YLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMVNQVELHPLNNQADLRAF 190 Query: 176 NATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTP 235 +I+ E+WSPL QG + ++ + KY KT AQ+++RW++ L+ IPKSV Sbjct: 191 CDAKQIKVEAWSPLGQG--KLLSNPILSAIGAKYNKTAAQVILRWNIQKNLITIPKSVHR 248 Query: 236 SRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQ 272 RI EN D++DF L +++ I L+ R GPDPD+ Sbjct: 249 ERIEENADIFDFELGAEDVMSIDALNTNSRYGPDPDE 285 >1VBJ-A nrPDB Length = 281 Score = 238 bits (608), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 117/276 (42%), Positives = 175/276 (63%), Gaps = 7/276 (2%) Query: 1 MANPTVIKLQDGNVMPQLGLGVWQASN-EEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MA +KL +G +MP LG G+W+ + E TA A++ GYR IDTAA YKNEE G+ Sbjct: 6 MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGR 65 Query: 60 ALKNASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYV 117 A+ + V REELF+TTKLWN D ++ A S+KKL L+Y+DLYL+HWP D ++ Sbjct: 66 AIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWP--GKDKFI 123 Query: 118 EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNA 177 + WK +L + +++IGV NF HH++ L+ V P++NQIELHPL+ Q+ L + Sbjct: 124 DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCK 183 Query: 178 THKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSR 237 + I +WSPL QG + + ++ + KYGKT AQ+++RW + +G++ IPKS +R Sbjct: 184 SKNIAVTAWSPLGQG--HLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEAR 241 Query: 238 IAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 I EN +++DF L +++ I ++ G R GPDP+ F Sbjct: 242 IKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPEVF 277 >1VP5-A nrPDB Length = 298 Score = 236 bits (601), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 119/264 (45%), Positives = 173/264 (65%), Gaps = 9/264 (3%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNAS- 65 + L +G MP LG GV+Q E+ + +A++VGYR IDTAA+Y NEEGVG+A+K A Sbjct: 18 VTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAIKRAID 77 Query: 66 ---VNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 120 V REELF+TTKLW D ++ ++A SLKKLQL+YIDLYL+H P + AW Sbjct: 78 EGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFGDVHC---AW 134 Query: 121 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 180 K M E+ K+GL+++IGV NF L L+ + P +NQIE+HP Q+++ + + Sbjct: 135 KAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVPAVNQIEIHPFYQRQEEIEFMRNYN 194 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 IQ E+W P A+G K +F V+R +A+KYGKT AQ+++RW G+V IPK+V R+ E Sbjct: 195 IQPEAWGPFAEGRKNIFQNGVLRSIAEKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKE 254 Query: 241 NFDVWDFRLDKDELGEIAKLDQGK 264 N ++DF L ++++ +IA LD+G+ Sbjct: 255 NISIFDFELTQEDMEKIATLDEGQ 278 >3D3F-A nrPDB Length = 275 Score = 232 bits (591), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 122/271 (45%), Positives = 187/271 (69%), Gaps = 7/271 (2%) Query: 6 VIKLQDGNVMPQLGLGVWQASN-EEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 +KL +G MP GLGV++ N E +++ A++ GYRSIDTAA YKNEEGVG +K + Sbjct: 7 TVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKES 66 Query: 65 SVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKG 122 V REELFIT+K+WN+D ++ A SL++LQLDY+DLYL+HWP D Y + W+ Sbjct: 67 GVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP--GKDKYKDTWRA 124 Query: 123 MIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQ 182 + +L K+G I++IGV NFQ+HHL+ L+ + + P++NQ+E HP + Q++L + IQ Sbjct: 125 LEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVNQVEFHPRLTQKELRDYCKGQGIQ 184 Query: 183 TESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENF 242 E+WSPL QG + D +V+ +A+K+ K+ AQ+++RW L G+V IPKS+ RI EN Sbjct: 185 LEAWSPLMQG--QLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENA 242 Query: 243 DVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 D++DF L ++++ +I L++ +R+GP+PD+ Sbjct: 243 DIFDFELSQEDMDKIDALNKDERVGPNPDEL 273 >4MHB-A nrPDB Length = 297 Score = 213 bits (541), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 111/259 (42%), Positives = 158/259 (61%), Gaps = 6/259 (2%) Query: 6 VIKLQDGNVMPQLGLGVWQASNE-EVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 +KL +G MP LG GV+Q +N E A+ A+E GYR IDTAA+Y+NE VG ALK + Sbjct: 17 TVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKLS 76 Query: 65 SVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKG 122 + R+ELFITTKLW D ++ + SL +LQLDY+DLYL+H P + AW+ Sbjct: 77 GIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---AWRA 133 Query: 123 MIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQ 182 M EL + G I++IGV NF L L+ + P +NQIE++P QQ W + IQ Sbjct: 134 MEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQ 193 Query: 183 TESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENF 242 E+W+P A+G G+F V+ + +KYGK+ Q+V+RW G+V + KSV R+ EN Sbjct: 194 PEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENI 253 Query: 243 DVWDFRLDKDELGEIAKLD 261 ++ DF L +++ +IA LD Sbjct: 254 NILDFELSAEDMLQIAALD 272 >3WCZ-A nrPDB Length = 308 Score = 207 bits (526), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 119/288 (41%), Positives = 172/288 (59%), Gaps = 27/288 (9%) Query: 6 VIKLQDGNVMPQLGLGVWQA------SNEEVITAIQKALEVGYRSIDTAAAYKNEE---- 55 I+L DGN +P + LG + S +EV A+ A+E GYR IDTAA Y++EE Sbjct: 7 CIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQVGQ 66 Query: 56 GVGKALKNASVNREELFITTKLWNDDHKRPR--EALLDSLKKLQLDYIDLYLMHWPV--- 110 G+ +A+ N V REELF+TTKLWND H R + AL +SLKKL LDYIDLYL+H+P+ Sbjct: 67 GIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIATK 126 Query: 111 ----PAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPL 166 P Y+E W+GM + ++ GL +SIGV NF + RL+ + + PVINQIE++P Sbjct: 127 PDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYIRPVINQIEVNPT 186 Query: 167 MQQRQLHAWNATHKIQTESWSPL----AQGGKGV----FDQKVIRDLADKYGKTPAQIVI 218 Q L A + I ++SP ++G G D + LA+KY K+ QI++ Sbjct: 187 NTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTLTALANKYRKSVGQILL 246 Query: 219 RWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 R+ +D GL+ IPKS RIA+N D++DF+L +E+ I + ++ R+ Sbjct: 247 RYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKNHRV 294 >2ALR-A nrPDB Length = 324 Score = 199 bits (507), Expect = 9e-52, Method: Compositional matrix adjust. Identities = 106/295 (35%), Positives = 163/295 (55%), Gaps = 35/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN- 63 + + L G MP +GLG W++ +V A++ AL VGYR ID AA Y NE +G+ALK Sbjct: 3 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 62 Query: 64 ----ASVNREELFITTKLWNDDHKRPRE---ALLDSLKKLQLDYIDLYLMHWPVPA---- 112 +V REELF+T+KLWN H P + AL +L LQL+Y+DLYLMHWP Sbjct: 63 VGPGKAVPREELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 121 Query: 113 --------------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVI 158 HY E WK + L +GL++++G+ NF + ++ V P + Sbjct: 122 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYG 210 Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+KYG Sbjct: 182 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 ++PAQI++RW + ++ IPKS+TPSRI +N V+DF +E+ ++ L++ R Sbjct: 242 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 296 >1HQT-A nrPDB Length = 326 Score = 197 bits (500), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 104/296 (35%), Positives = 163/296 (55%), Gaps = 35/296 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 + + L G MP +GLG W++ +V AI+ AL VGYR ID AA + NE +G+AL+ Sbjct: 5 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEALQET 64 Query: 65 -----SVNREELFITTKLWNDDHKRPRE---ALLDSLKKLQLDYIDLYLMHWPVPA---- 112 +V REELF+T+KLWN H P + AL +L LQL+Y+DLYLMHWP Sbjct: 65 VGPGKAVPREELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 123 Query: 113 --------------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVI 158 HY + WK + L +GL++++G+ NF + ++ V P + Sbjct: 124 NPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRPAV 183 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYG 210 Q+E HP + Q +L A ++ ++SPL + + ++ V++ LA+KY Sbjct: 184 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYN 243 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 ++PAQI++RW + ++ IPKSVTPSRI +N V+DF +E+ ++ L++ R Sbjct: 244 RSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRF 299 >4GAC-A nrPDB Length = 324 Score = 194 bits (492), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 104/295 (35%), Positives = 162/295 (54%), Gaps = 35/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 + + L G MP +GLG W++ +V AI+ AL GYR ID A+ Y NE +G+ALK + Sbjct: 3 SSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 62 Query: 65 -----SVNREELFITTKLWNDDHKRPRE---ALLDSLKKLQLDYIDLYLMHWPVPA---- 112 +V REELF+T+KLWN H P + AL +L LQL+Y+DLYLMHWP Sbjct: 63 VGSGKAVPREELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 121 Query: 113 --------------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVI 158 HY E WK + L +GL+K++G+ NF + ++ V P + Sbjct: 122 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYG 210 Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+K+G Sbjct: 182 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 ++PAQI++RW + ++ IPKS+ PSRI +N V+DF +E+ ++ L++ R Sbjct: 242 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWR 296 >1ZUA-X nrPDB Length = 317 Score = 193 bits (491), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 106/295 (35%), Positives = 171/295 (57%), Gaps = 34/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 T ++L MP +GLG W++ +V A++ A++ GYR ID A Y+NE VG+A++ Sbjct: 4 TFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEK 63 Query: 65 ----SVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP--------- 109 +V RE+LFI +KLW +RP R+A +LK L+L Y+D+YL+HWP Sbjct: 64 IQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDL 123 Query: 110 VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVI 158 P D +++AW+ M EL EGL+K++GV NF +++L+++ G+ PV Sbjct: 124 FPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVT 183 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK--------GVFDQKVIRDLADKYG 210 NQ+E HP + Q +L + + I ++SPL + + + I+++A K+ Sbjct: 184 NQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHK 243 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ ++VIPKSVTP+RI EN V+DF+L +E+ I ++ R Sbjct: 244 KTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWR 298 >4HBK-A nrPDB Length = 344 Score = 191 bits (486), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 104/281 (37%), Positives = 167/281 (59%), Gaps = 31/281 (11%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA-- 64 +K+ +G +P +GLG W + EV A++KALE+GYR +D A Y+NE +G+AL+NA Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALN 97 Query: 65 --SVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVP-------- 111 + RE++FIT+KLWN RP R+A ++LK L+L+Y+DLYL+HWPVP Sbjct: 98 SLRLKREDIFITSKLWNTFF-RPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLF 156 Query: 112 --------AIDH--YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQI 161 +D+ + + WK M +L EGL+KSIG+ NF +Q +++ + P QI Sbjct: 157 PTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQI 216 Query: 162 ELHPLMQQRQLHAWNATHKIQTESWSPLAQ-----GGKGVFDQKVIRDLADKYGKTPAQI 216 E+H +L + + + +++PL G + + + ++A ++ KTPAQ+ Sbjct: 217 EIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAHSPGKVNLLTKPCVLEIAHRHKKTPAQV 276 Query: 217 VIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEI 257 ++R+ L L+V+PKSVT RI ENF V+DF+L +E+ E+ Sbjct: 277 LLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHEL 317 >3H7R-A nrPDB Length = 331 Score = 187 bits (476), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 108/289 (37%), Positives = 164/289 (56%), Gaps = 29/289 (10%) Query: 1 MANPT-VIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MA P +L G +P +GLG + V TAI++A+++GYR ID A+ Y NE+ +G Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTYAM----VATAIEQAIKIGYRHIDCASIYGNEKEIGG 76 Query: 60 ALK----NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP---- 109 LK + V REELFIT+KLW++DH + +AL +L+ LQ+DY+DLYL+HWP Sbjct: 77 VLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLK 136 Query: 110 ----VPAIDHYVE-----AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160 +P + + WK M L G ++IGV NF L L++ VTP +NQ Sbjct: 137 KESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQ 196 Query: 161 IELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG-----VFDQKVIRDLADKYGKTPAQ 215 +E HP+ QQ+ LH + + +SPL KG V ++ ++A+K GKT AQ Sbjct: 197 VECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQ 256 Query: 216 IVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 + +RW L +G V+PKS + +R+ EN DV+D+ + +D + + + Q K Sbjct: 257 VALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQEK 305 >1QWK-A nrPDB Length = 317 Score = 187 bits (476), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 116/300 (38%), Positives = 167/300 (55%), Gaps = 36/300 (12%) Query: 1 MANPTV-IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 M++ T IKL +G MP +GLG WQ+S EVITA++ A++ GYR IDTA+ Y+NEE +G Sbjct: 1 MSSATASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGT 60 Query: 60 ALKN----ASVNREELFITTKLWNDDHK--RPREALLDSLKKLQLDYIDLYLMHWPVPAI 113 A+K V REELFITTK W + + L +SLKKLQL+Y+DLYL H P Sbjct: 61 AIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN 120 Query: 114 DHYVE--------AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN-QIELH 164 D E W+ + K GL K++GV N+ + R + G+TPV N Q+ELH Sbjct: 121 DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRAL-ALGLTPVHNSQVELH 179 Query: 165 PLMQQRQLHAWNATHKIQTESWSPLAQGGKGVF------------------DQKVIRDLA 206 Q + H I S++ L G+ F DQ V+ LA Sbjct: 180 LYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPAPSDLQDQNVLA-LA 238 Query: 207 DKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 +K KTPAQ+++R+ LD G ++PKS+ +RI ENF+V+DF L ++++ ++ + +RL Sbjct: 239 EKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEESKNSQRL 298 >3H7U-A nrPDB Length = 335 Score = 186 bits (473), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 109/289 (37%), Positives = 155/289 (53%), Gaps = 25/289 (8%) Query: 1 MANP-TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MAN T KL G P +GLG WQAS V A+ A+++GYR ID A Y NE+ +G Sbjct: 21 MANAITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGA 80 Query: 60 ALK----NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAI 113 LK + V RE+LFIT+KLW DH + EAL +LK LQL+Y+DLYL+HWP Sbjct: 81 VLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIK 140 Query: 114 DHYV-------------EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160 V WK M L G ++IGV NF L L++ V P +NQ Sbjct: 141 KGSVGIKPENLLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPAVNQ 200 Query: 161 IELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRD-----LADKYGKTPAQ 215 +E HP +Q +L + + + ++SPL G V+++ +A+K GK+PAQ Sbjct: 201 VECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSDVLKNPILNMVAEKLGKSPAQ 260 Query: 216 IVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 + +RW L G V+PKS RI ENF+V+D+ + + A+++Q + Sbjct: 261 VALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIEQAR 309 >2BGQ-A nrPDB Length = 344 Score = 185 bits (470), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 102/277 (36%), Positives = 153/277 (55%), Gaps = 19/277 (6%) Query: 9 LQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK---NAS 65 L+ G+ MP +GLG W+A ++ + E GYR +DTAA Y E+ VGK LK A Sbjct: 42 LKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAMEAG 101 Query: 66 VNREELFITTKLW--NDDHKRPREALLDSLKKLQLDYIDLYLMHWPV---------PAID 114 ++R++LF+T+K+W N +R R AL ++LK LQLDYIDLY +HWP P Sbjct: 102 IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMPPEAG 161 Query: 115 HYVE-----AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQ 169 +E WK M L K+GL+K IGVCN+ + L RL+ + P + Q+E+HP + Sbjct: 162 EVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQMEMHPGWKN 221 Query: 170 RQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVI 229 ++ H I ++SPL K + V+ +A+K KTP Q++I+W L G VI Sbjct: 222 DKIFEACKKHGIHITAYSPLGSSEKNLAHDPVVEKVANKLNKTPGQVLIKWALQRGTSVI 281 Query: 230 PKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 PKS RI EN V+ + + +++ + + KR+ Sbjct: 282 PKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRV 318 >5JH1-A nrPDB Length = 309 Score = 183 bits (464), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 105/281 (37%), Positives = 156/281 (55%), Gaps = 23/281 (8%) Query: 9 LQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN----A 64 L G +P +GLG WQ+ V A+ A++ GYR ID A Y NE+ +G ALK Sbjct: 6 LNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKLFEEG 65 Query: 65 SVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV-------PAIDH 115 V RE++FIT+KLWND H + EAL DSL LQL+Y+DLYL+HWP + ++ Sbjct: 66 VVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNTSPEN 125 Query: 116 YVE-----AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQR 170 +V W M +L G ++IGV NF L L+ V P ++Q+E HP QQ Sbjct: 126 FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPGWQQT 185 Query: 171 QLHAWNATHKIQTESWSPLAQGGK-----GVFDQKVIRDLADKYGKTPAQIVIRWHLDSG 225 +LH++ + + ++SPL G V + +I +A+K GKT AQ+ +RW++ G Sbjct: 186 KLHSFCQSTGVHLTAYSPLGSPGTTWMNGNVLKEPIIISIAEKLGKTSAQVALRWNIQMG 245 Query: 226 LVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 V+PKS RI +N DV+D+ + D L + +++ Q + L Sbjct: 246 HSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQARLL 286 >5ZCM-A nrPDB Length = 341 Score = 182 bits (462), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 111/302 (36%), Positives = 153/302 (50%), Gaps = 42/302 (13%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKN----EEGVGKALK 62 IKL G MP +G G W+ N + A++VGYR D A Y N EG+ +AL Sbjct: 24 IKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRALD 83 Query: 63 NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV---------- 110 V R+ELFIT+KLWN H K AL L ++LDYIDL+L+H+P+ Sbjct: 84 EGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPFEEK 143 Query: 111 --PAID-------HY-----VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP 156 PA HY +E WK M +L K G KSIG+ NF + L+ + P Sbjct: 144 YPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLRGAEIKP 203 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPL------------AQGGKGVFDQKVIRD 204 + QIE HP +QQ +L + + I ++S A +F+ K I Sbjct: 204 AVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFEHKTITS 263 Query: 205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 +ADKY KTPAQ+++RW + +IPKS P R+ +N +V DF L K++ EI+KLDQ Sbjct: 264 IADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEISKLDQDL 323 Query: 265 RL 266 R Sbjct: 324 RF 325 >1FRB-A nrPDB Length = 315 Score = 177 bits (449), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 112/295 (37%), Positives = 171/295 (57%), Gaps = 34/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL--- 61 T ++L MP +GLG W++ +V A++ A++ GYR ID A AY NE VG+A+ Sbjct: 2 TFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQEK 61 Query: 62 -KNASVNREELFITTKLWND--DHKRPREALLDSLKKLQLDYIDLYLMHWP--------- 109 K +V RE+LFI +KLW + K +EA +L L+LDY+DLYL+HWP Sbjct: 62 IKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKEL 121 Query: 110 VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVI 158 P D ++EAW+GM EL +GL+K++GV NF ++RL+++ G+ PV Sbjct: 122 FPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVT 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK--------GVFDQKVIRDLADKYG 210 NQ+E HP + Q +L + + I ++SPL + + + I+++A K+ Sbjct: 182 NQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAKHE 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ +VVIPKSVTPSRI EN V+DF+L +E+ I ++ R Sbjct: 242 KTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWR 296 >1C9W-A nrPDB Length = 315 Score = 174 bits (440), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 111/295 (37%), Positives = 170/295 (57%), Gaps = 34/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL--- 61 T ++L MP +GLG WQ+ +V A++ A++ GYR ID A AY NE VG+A+ Sbjct: 2 TFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQEK 61 Query: 62 -KNASVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP--------- 109 K +V RE+LFI +KLW +R +EA +L L+LDY+DLYL+HWP Sbjct: 62 IKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKEL 121 Query: 110 VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVI 158 P D +++AW+ M EL EGL+K++GV NF ++R++++ G+ PV Sbjct: 122 FPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPVT 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK--------GVFDQKVIRDLADKYG 210 NQ+E HP + Q +L + + I ++SPL + + + I+++A K+ Sbjct: 182 NQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAKHK 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ +VVIPKSVTP+RI ENF V+DF+L E+ I ++ R Sbjct: 242 KTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWR 296 >5Z6T-A nrPDB Length = 343 Score = 172 bits (435), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 108/306 (35%), Positives = 158/306 (51%), Gaps = 43/306 (14%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEE----GVGKALK 62 IKL G MP +G G W+ + I +A++ GYR D A Y NE+ GV KA+ Sbjct: 29 IKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKAID 88 Query: 63 NASVNREELFITTKLWNDDHK--RPREALLDSLKKLQLDYIDLYLMHWPV-----PAIDH 115 V RE+LF+T+KLWN+ H +AL +L LQ+DY+DL+L+H+PV P + Sbjct: 89 EGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPLEEK 148 Query: 116 Y-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP 156 Y +E WK + +L K G I+SIGV NF L L+ + P Sbjct: 149 YPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGATIKP 208 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPL------------AQGGKGVFDQKVIRD 204 + Q+E HP +QQ +L + + I ++S A +F+ + I+ Sbjct: 209 SVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENETIKA 268 Query: 205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 +A K+GK+PAQ+++RW G+ +IPKS T R+ EN DV F LD+ + +IAKLD Sbjct: 269 IAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLDINL 328 Query: 265 RLGPDP 270 R DP Sbjct: 329 RFN-DP 333 >1DLA-A nrPDB Length = 314 Score = 172 bits (435), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 109/292 (37%), Positives = 168/292 (57%), Gaps = 34/292 (11%) Query: 9 LQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVG----KALKNA 64 L G MP LGLG W++ +V A++ A+++GYR ID A Y+NE VG + L+ Sbjct: 5 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQ 64 Query: 65 SVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP------------- 109 V RE+LFI +KLW DH++ + A +L+ L+LDY+DLYL+HWP Sbjct: 65 VVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLD 124 Query: 110 -----VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVINQIE 162 VP +VE W+ M EL EGL+K+IGV NF +++++++ G+ P +NQIE Sbjct: 125 GDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 184 Query: 163 LHPLMQQRQLHAWNATHKIQTESWSPLAQGGK--------GVFDQKVIRDLADKYGKTPA 214 +HP + Q +L + + I ++SPL + + + I+ +A KY KT A Sbjct: 185 VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTA 244 Query: 215 QIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 Q++IR+ + L+VIPKSVTP RIAENF V+DF L +++ + ++ R+ Sbjct: 245 QVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRV 296 >4JQA-A nrPDB Length = 331 Score = 171 bits (434), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 105/300 (35%), Positives = 160/300 (53%), Gaps = 42/300 (14%) Query: 6 VIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 +KL DG+ MP LG G + + + + A++ A+E G+ ID+A Y NEE VG A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 63 ----NASVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVP---- 111 + SV RE++F T+KLW++ H RP R AL SLK LQLDY+DLYL+H+PV Sbjct: 67 SKIADGSVKREDIFYTSKLWSNSH-RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125 Query: 112 ---------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT- 155 +D W+ M + + GL KSIGV NF L+ ++++ G+ Sbjct: 126 EEVIPKDENGKILFDTVD-LCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKY 184 Query: 156 -PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDL 205 PV NQ+E HP QR+L + + I ++S L + + V+ L Sbjct: 185 KPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCAL 244 Query: 206 ADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 A K+ +TPA I +R+ L G+VV+ KS RI +N V++F+L +E+ I L++ R Sbjct: 245 AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVR 304 >1K8C-A nrPDB Length = 322 Score = 171 bits (433), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 109/306 (35%), Positives = 157/306 (51%), Gaps = 43/306 (14%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNAS- 65 IKL G++MP +G G W+ +N + +A++ GYR D A Y NE+ VG +K A Sbjct: 8 IKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGDGVKRAID 67 Query: 66 ---VNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP-----VPAIDH 115 V REE+F+T+KLWN+ H K AL +L L++DY+DL+L+H+P VP + Sbjct: 68 EGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFKFVPIEEK 127 Query: 116 Y-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP 156 Y +E WK + +L G IKSIGV NF L L+ + P Sbjct: 128 YPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRGATIKP 187 Query: 157 VINQIELHPLMQQRQLHAW--------NATHKIQTESWSPLAQG----GKGVFDQKVIRD 204 + Q+E HP +QQ +L + A +S+ + QG +F I+ Sbjct: 188 AVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTLFAHDTIKA 247 Query: 205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 +A KY KTPA++++RW G+ VIPKS P R+ +N F L K++ EIAKLD G Sbjct: 248 IAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEEIAKLDIGL 307 Query: 265 RLGPDP 270 R DP Sbjct: 308 RFN-DP 312 >5UXF-A nrPDB Length = 342 Score = 168 bits (425), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 102/303 (33%), Positives = 166/303 (54%), Gaps = 42/303 (13%) Query: 6 VIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 +KL DG+++P LG G + + + + A AL+VGYR +DTA AY+ EE +G+A++ Sbjct: 26 CVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQ 85 Query: 63 NA----SVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVP---- 111 +A V RE+LF+TTKLW RP + AL SLKKLQLDY+DLY+MH+PVP Sbjct: 86 SAIAAGVVKREDLFVTTKLWCTCF-RPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSG 144 Query: 112 ---------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGV-- 154 +D + + W+ + E + GL+KSIGV NF L+R++++ G+ Sbjct: 145 DNDFPVNEQGKSLLDTVD-FCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKY 203 Query: 155 TPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDL 205 PV NQ+E H + QR+L + + I ++ L Q + + V+ D+ Sbjct: 204 KPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDV 263 Query: 206 ADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 A K ++PA I +R+ + G+V + +S + + EN V+ F+L +++ + L++ R Sbjct: 264 AKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFR 323 Query: 266 LGP 268 P Sbjct: 324 YLP 326 >1Q5M-A nrPDB Length = 322 Score = 167 bits (424), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 102/298 (34%), Positives = 162/298 (54%), Gaps = 40/298 (13%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 + L DG+ +P LG G + + + + A + A++ G+R ID+A YKNE+ VG A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 ---NASVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWP------- 109 + +V RE++F T+KLW H RP R +L DSLK LQLDY+DLY++H+P Sbjct: 67 KIADGTVKREDIFYTSKLWCTFH-RPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGV 125 Query: 110 --VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 +P +H W+ M + + GL KSIGV NF L+ ++++ G+ P Sbjct: 126 EIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 185 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLAD 207 V NQ+E HP + Q +L + + I ++S L Q + + +I LA Sbjct: 186 VCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAK 245 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 K+ +TPA I +R+ L G+VV+ KS T RI EN V++F+L +++ I L++ R Sbjct: 246 KHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFR 303 >3KRB-A nrPDB Length = 334 Score = 167 bits (422), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 101/297 (34%), Positives = 157/297 (52%), Gaps = 49/297 (16%) Query: 16 PQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA----LKNAS--VNRE 69 P+LG G WQA E V TA++ AL GYR ID A Y+NEE +G+A K+AS + RE Sbjct: 26 PRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSGIKRE 85 Query: 70 ELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVPAIDHYV--------- 117 +++IT+KLWN +H RP RE ++ LQ+DY+DL+L+HWP+ + + V Sbjct: 86 DVWITSKLWNYNH-RPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKDAE 144 Query: 118 -----------EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPL 166 + W+ M +L +EGL+K IGV N+ + L L++ + P++NQIE+HP Sbjct: 145 GRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHPW 204 Query: 167 MQQRQLHAWNATHKIQTESWSPLAQGGKG-------------VFDQKVIRDLADKYGKTP 213 + + I ++SP+ GG + + K ++ +AD G +P Sbjct: 205 HPNDATVKFCLDNGIGVTAYSPM--GGSYADPRDPSGTQKNVILECKTLKAIADAKGTSP 262 Query: 214 AQIVIRWHL----DSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 + + WH+ S VIPKS TP+RI NF + +L D++ I + KR+ Sbjct: 263 HCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRI 319 >3RX4-A nrPDB Length = 336 Score = 166 bits (421), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 108/292 (36%), Positives = 164/292 (56%), Gaps = 34/292 (11%) Query: 9 LQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA----LKNA 64 L +G MP LGLG W++ +V A++ A++VGYR ID A Y+NE VG A L+ Sbjct: 27 LNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQ 86 Query: 65 SVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP------------- 109 V REELFI +KLW H++ + A +L L+LDY+DLYL+HWP Sbjct: 87 VVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLD 146 Query: 110 -----VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVINQIE 162 VP+ + ++ W M EL EGL+K+IG+ NF ++ ++++ G+ P +NQIE Sbjct: 147 ESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIE 206 Query: 163 LHPLMQQRQLHAWNATHKIQTESWSPLAQGGK--------GVFDQKVIRDLADKYGKTPA 214 HP + Q +L + + I ++SPL + + + I+ +A K+ KT A Sbjct: 207 CHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTA 266 Query: 215 QIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 Q++IR+ + LVVIPKSVTP RIAENF V+DF L ++ + ++ R+ Sbjct: 267 QVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRV 318 >3G1R-A nrPDB Length = 346 Score = 165 bits (417), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 99/299 (33%), Positives = 154/299 (51%), Gaps = 39/299 (13%) Query: 7 IKLQDGNVMPQLGLGVWQASNEE----VITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 I L DGN +P +GLG + T+++ A++ GYR ID A Y+NE VG+A++ Sbjct: 30 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 89 Query: 63 N----ASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV---PAI 113 V RE++F KLW +H + R L +L+ LQLDY+DLY++ P+ P Sbjct: 90 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 149 Query: 114 DHY---------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 + Y W+ M + GL+KS+GV NF L+ ++++ G+ P Sbjct: 150 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 209 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGV---------FDQKVIRDLAD 207 V NQ+E HP Q +L + H I ++SPL + ++ L Sbjct: 210 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 269 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 +Y KT AQIV+R+++ G+VVIPKS RI ENF ++DF L ++E+ +I L++ R Sbjct: 270 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 328 >3O3R-A nrPDB Length = 316 Score = 164 bits (414), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 171/295 (57%), Gaps = 34/295 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL--- 61 T +KL+ MP +GLG W++ +V A++ A++ GYR D A Y+NE VG+A+ Sbjct: 3 TFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEK 62 Query: 62 -KNASVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP--------- 109 K +V RE+LFI +KLW+ ++ +EA +L L+LDY+DLYL+HWP Sbjct: 63 IKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEF 122 Query: 110 ---------VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVI 158 + + +++AW+GM EL +GL+K++GV NF ++RL+++ G+ PV Sbjct: 123 LPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVT 182 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYG 210 NQ+E HP + Q +L + + I ++SPL + V + I+++A K+ Sbjct: 183 NQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHK 242 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ + VIPKSVT S I EN V+DF+L ++++ I L++ R Sbjct: 243 KTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWR 297 >5JM5-A nrPDB Length = 332 Score = 163 bits (412), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 101/297 (34%), Positives = 155/297 (52%), Gaps = 40/297 (13%) Query: 6 VIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 +KL DG+ MP LG G + + + + + A+E G+R ID+A Y NEE VG A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 63 ----NASVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPVPA--- 112 + SV RE++F T+KLW+ H RP R AL +SLKK QLDY+DLYL+H P+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSTFH-RPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125 Query: 113 ---------------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT-- 155 I W+ M + + GL KSIGV NF L+ ++++ G+ Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185 Query: 156 PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLA 206 PV NQ+E HP + +L + + I ++S L + + V+ LA Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245 Query: 207 DKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQG 263 K+ +TPA I +R+ L G+VV+ KS RI +N V++F+L +++ I LD+ Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRN 302 >4IJC-A nrPDB Length = 344 Score = 157 bits (398), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 99/287 (34%), Positives = 151/287 (52%), Gaps = 38/287 (13%) Query: 7 IKLQDGNVMPQLGLGVWQASNE--EVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK-- 62 L +G +P LGLG + E A++ A++ GYR IDTA AY+ E VG+A+K Sbjct: 25 FSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKEL 84 Query: 63 --NASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPV---------- 110 + S+ RE+LFITTK+W +L +SLK L L+Y+DL L HWP+ Sbjct: 85 LEDGSIKREDLFITTKVWPVLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKG 144 Query: 111 -------PAIDH----------YVEAWKGMIELQ---KEGLIKSIGVCNFQIHHLQRLID 150 P D Y+E +K + ++ + +++IGV NF I +L+RLI Sbjct: 145 ISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIK 204 Query: 151 ETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYG 210 E V P +NQ+E HP + Q +L + H I ++SPL G +++ LA+KY Sbjct: 205 ECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKYN 264 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEI 257 T ++I +H+ G +VIP+S+ P RI+ + + L KDEL E+ Sbjct: 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQEL 309 >2FVL-A nrPDB Length = 324 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 99/297 (33%), Positives = 155/297 (52%), Gaps = 38/297 (12%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 ++L DG+ MP LG G + + + + A+E G+R ID+A Y NEE VG A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 ---NASVNREELFITTKLWND--DHKRPREALLDSLKKLQLDYIDLYLMHWPVP------ 111 + SV RE++F T+KLW + + AL SLKKLQLDY+DLYL+H+P+ Sbjct: 69 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 128 Query: 112 ---------AIDHYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 I V+ W+ M + + GL KSIGV NF L+ ++++ G+ PV Sbjct: 129 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKPV 188 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLADK 208 NQ+E HP + Q +L + + I + S L + + V+ LA K Sbjct: 189 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 248 Query: 209 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 + +TPA I +R+ L G+VV+ KS RI EN V++F+L +++ + L++ R Sbjct: 249 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 305 >1AFS-A nrPDB Length = 323 Score = 154 bits (390), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 95/298 (31%), Positives = 158/298 (53%), Gaps = 40/298 (13%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 + L DGN +P LG G + + +EVI A + A++ G+R D+A Y+ EE VG+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 ---NASVNREELFITTKLWNDDHKRP---REALLDSLKKLQLDYIDLYLMHWPV------ 110 + +V RE++F T+KLW+ H RP R L +LK QLDY+DLY++H+P+ Sbjct: 68 KIEDGTVKREDIFYTSKLWSTFH-RPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGD 126 Query: 111 ---PAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 P +H + W+ M + + GL KSIGV NF L+R++++ G+ P Sbjct: 127 IFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKP 186 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLAD 207 V NQ+E H + Q ++ + + I S+ L Q + D V+ +A Sbjct: 187 VCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAK 246 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KY +TPA + +R+ L G+V + +S RI E V++F+L +++ + L++ R Sbjct: 247 KYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFR 304 >2HE8-A nrPDB Length = 323 Score = 152 bits (383), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 94/303 (31%), Positives = 156/303 (51%), Gaps = 42/303 (13%) Query: 6 VIKLQDGNVMPQLGLGV-----WQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 60 + L DGN +P LG G S + +T I A++ G+ D+A+ Y E+ VG+A Sbjct: 7 CVILNDGNFIPVLGFGTALPLECPKSKAKELTKI--AIDAGFHHFDSASVYNTEDHVGEA 64 Query: 61 LK----NASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPV---- 110 ++ + +V RE++F T+K+W + R +L SL+KLQ DY+DLYL+H+P+ Sbjct: 65 IRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKP 124 Query: 111 -----PAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT- 155 P +H W+ M + + GL KSIGV NF L+ ++++ G+ Sbjct: 125 GEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKY 184 Query: 156 -PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDL 205 PV NQ+E HP + Q +L + + I ++ L Q + D+ V+ + Sbjct: 185 KPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSM 244 Query: 206 ADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 A KY +TPA I +R+ L G+VV+ S+ RI EN V++F+L +++ + L++ R Sbjct: 245 AKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMR 304 Query: 266 LGP 268 P Sbjct: 305 YIP 307 >3WG6-A nrPDB Length = 307 Score = 150 bits (378), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 94/287 (32%), Positives = 155/287 (54%), Gaps = 28/287 (9%) Query: 7 IKLQDGNVMPQLGLGVWQAS--------NEEVITAIQKALEVGYRSIDTAAAYKNEEGVG 58 KL +GN +P + G ++++I ++ AL G+R ID A Y + +G Sbjct: 11 FKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGTNKEIG 70 Query: 59 KALKNASVNREELFITTKLWNDDH---------KRPREALLDSLKKLQLDYIDLYLMHWP 109 ALKN +NR+++FIT K + +H + P AL L+ L L+Y+DLYL+H+P Sbjct: 71 IALKNVGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVDLYLIHFP 130 Query: 110 VPAIDHY----VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLID-ETGVTPVINQIELH 164 + + VEAW+ + + EGL ++IGV NF I +L+ ++D T PV+NQIE Sbjct: 131 YISEKSHGFDLVEAWRYLERAKNEGLARNIGVSNFTIENLKSILDANTDSIPVVNQIEFS 190 Query: 165 PLMQQRQ--LHAWNATHKIQTESWSPLA---QGGKGVFDQKVIRDLADKYGKTPAQIVIR 219 +Q + + ++ I E++ PL QG G D KV+ L++KY + QI++R Sbjct: 191 AYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRPGPLD-KVLSKLSEKYKRNEGQILLR 249 Query: 220 WHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 W L G++ I + RI + +++DF LDK++ +I K+ + K L Sbjct: 250 WVLQRGILPITTTSKEERINDVLEIFDFELDKEDEDQITKVGKEKTL 296 >4H8N-A nrPDB Length = 310 Score = 146 bits (369), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 85/250 (34%), Positives = 146/250 (58%), Gaps = 18/250 (7%) Query: 29 EVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNREELFITTKL---WND---DH 82 E++ I L++G+R IDTA AY ++ VG+ALK V RE++++TTK W Sbjct: 44 ELVDNILLGLKLGFRHIDTAEAYNTQKEVGEALKRTDVPREDIWVTTKYSPGWGSIKAYS 103 Query: 83 KRPREALLDSLKKLQLDYIDLYLMHWPVPAIDH---YV--EAWKGMIELQKEGLIKSIGV 137 K P +++ +L +L +DY+DL+L+H P + Y +AW+ ++E +K G ++ IG+ Sbjct: 104 KSPSDSIDKALAQLGVDYVDLFLIHSPFFTTEQTHGYTLEQAWEALVEAKKAGKVREIGI 163 Query: 138 CNFQIHHLQRLIDET---GVTPVINQIELHPLMQ--QRQLHAWNATHKIQTESWSPLAQG 192 N I HL++L + PV+NQIE HP +Q + + + H I E++SPLA Sbjct: 164 SNAAIPHLEKLFAASPSPEYYPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLAPL 223 Query: 193 GKGVFDQ--KVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLD 250 + + + ++ LA+KY KT AQ+++R+ L G++ + S SR+ E+ +++DF L Sbjct: 224 ARVETNALAETLKRLAEKYKKTEAQVLLRYTLQRGILPVTTSSKESRLKESLNLFDFELT 283 Query: 251 KDELGEIAKL 260 +E+ EI K+ Sbjct: 284 DEEVNEINKI 293 >3UP8-A nrPDB Length = 298 Score = 145 bits (367), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 146/257 (56%), Gaps = 12/257 (4%) Query: 10 QDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNRE 69 +G +P LG G ++ S EV+ + +AL++G+R +DTA Y NE VG+A++ + + R Sbjct: 29 SNGANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQKSGIPRA 88 Query: 70 ELFITTKLWNDDHKRPR--EALLDSLKKLQLDYIDLYLMHWP---VPAIDHYVEAWKGMI 124 ++F+TTK+W D+++ ++ +SL+KL+ D++DL L+HWP VP E + Sbjct: 89 DVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGSDVP----MAERIGALN 144 Query: 125 ELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTE 184 E++ G ++ IG+ NF ++ + NQ+E HP + Q ++ + Sbjct: 145 EVRNAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYHPYLDQTKVLQTARRLGMSLT 204 Query: 185 SWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHL-DSGLVVIPKSVTPSRIAENFD 243 S+ +A G V ++ ++ ++GKT AQ+ +RW + ++V+ K+ T +R+ ENF Sbjct: 205 SYYAMANG--KVPADPLLTEIGGRHGKTAAQVALRWLVQQQDVIVLSKTATEARLKENFA 262 Query: 244 VWDFRLDKDELGEIAKL 260 ++DF L ++E+ + +L Sbjct: 263 IFDFALTREEMAAVREL 279 >1PZ1-A nrPDB Length = 333 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/142 (38%), Positives = 81/142 (57%), Gaps = 16/142 (11%) Query: 18 LGLGVWQASNEEV-ITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFI 73 +G +W ++E+ I I+ AL+ G IDTA AY ++EE VGKA+K + R+++ + Sbjct: 23 IGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKE-YMKRDQVIL 81 Query: 74 TTKL---WNDDH-----KRPR--EALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGM 123 TK W ++ R R E + +SLK+LQ DYIDLY +HWP P + E + M Sbjct: 82 ATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWPDPLVP-IEETAEVM 140 Query: 124 IELQKEGLIKSIGVCNFQIHHL 145 EL G I++IGV NF I + Sbjct: 141 KELYDAGKIRAIGVSNFSIEQM 162 >1PYF-A nrPDB Length = 312 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 129/290 (44%), Gaps = 54/290 (18%) Query: 19 GLGVWQASNEEV-ITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFIT 74 G ++ NEE +++A+ G +DTA Y ++EE +G+ L+ NRE++ I Sbjct: 25 GHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLR--EFNREDVVIA 82 Query: 75 TK----------LWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWK 121 TK ++++ ++++ +SLK+L DYIDL+ +H+P D + EA Sbjct: 83 TKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP----DEHTPKDEAVN 138 Query: 122 GMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKI 181 + E++K G I+SIGV NF + L+ + V + + L ++ + H I Sbjct: 139 ALNEMKKAGKIRSIGVSNFSLEQLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNI 198 Query: 182 QTESWSPLAQG---GK----GVFDQKVIRD----------------------LADKYGKT 212 + PL G GK F + +R+ +A+K+ Sbjct: 199 SFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVD 258 Query: 213 PAQIVIRWHLDSGL--VVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKL 260 IV+ W+L ++IP + ++ +N D L ++++ I KL Sbjct: 259 IPHIVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQEDISFIDKL 308 >4R9O-A nrPDB Length = 301 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 104/254 (40%), Gaps = 44/254 (17%) Query: 23 WQASNEEVITAIQKALEVGYRSIDTA---AAYKNEEGVGKALKNASVNREELFITTKLWN 79 W S ++++ I++ L++G ++D A Y+ E G+AL A RE+L I TK Sbjct: 30 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHLREKLQIVTKCGI 89 Query: 80 DDHKRP-----------REALLD---SLKKLQLDYIDLYLMHWPVPAIDH--YVEAWKGM 123 R R +L SLK L DY+D+ L+H P P +D EA++ Sbjct: 90 ATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDADDVAEAFQ-- 147 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW---NATHK 180 L + G ++ GV NF L T NQ+E+ P+ Q L + Sbjct: 148 -HLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLR 206 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 I+ +WS L GG +F+ + + L + L VI + + S I + Sbjct: 207 IRPMAWSCL--GGGRLFNDEAYQPLRQE-----------------LSVIAQELNASSIEQ 247 Query: 241 NFDVWDFRLDKDEL 254 W RL L Sbjct: 248 VVYAWILRLPSQPL 261 >1OG6-A nrPDB Length = 298 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 103/254 (40%), Gaps = 44/254 (17%) Query: 23 WQASNEEVITAIQKALEVGYRSIDTA---AAYKNEEGVGKALKNASVNREELFITTKL-- 77 W S ++++ I++ L++G ++D A Y+ E G+ALK A RE + I +K Sbjct: 27 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSKCGI 86 Query: 78 ------------WNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAID--HYVEAWKGM 123 + D ++ SL L D++DL L+H P P +D +A+K Sbjct: 87 ATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDADEVADAFK-- 144 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW---NATHK 180 L + G ++ GV NF L T NQ+E+ P+ Q L + Sbjct: 145 -HLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLR 203 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 ++ +WS L GG +F+ + L D+ L V+ + + I + Sbjct: 204 VRPMAWSCL--GGGRLFNDDYFQPLRDE-----------------LAVVAEELNAGSIEQ 244 Query: 241 NFDVWDFRLDKDEL 254 + W RL L Sbjct: 245 VVNAWVLRLPSQPL 258 >1LQA-A nrPDB Length = 346 Score = 53.9 bits (128), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/167 (31%), Positives = 69/167 (41%), Gaps = 47/167 (28%) Query: 18 LGLGVW----QASNEEVITAIQKALEVGYRSIDTAAAYK----------NEEGVGKALKN 63 LGLG Q S + + A+ G ID A Y E VG L Sbjct: 16 LGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTETYVGNWLAK 75 Query: 64 ASVNREELFITTKLW-----NDDHKRP---------REALLDSLKKLQLDYIDLYLMHWP 109 +RE+L I +K+ ND RP REAL DSLK+LQ DY+DLY +HWP Sbjct: 76 HG-SREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLDLYQVHWP 134 Query: 110 -----------------VPAIDHYVEAWKGMIELQKEGLIKSIGVCN 139 PA+ ++ + E Q+ G I+ IGV N Sbjct: 135 QRPTNCFGKLGYSWTDSAPAVS-LLDTLDALAEYQRAGKIRYIGVSN 180 >3EB3-A nrPDB Length = 327 Score = 47.4 bits (111), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 86/209 (41%), Gaps = 29/209 (13%) Query: 10 QDGNVMPQLGLGVW-----QASNEEVITAIQKALEVGYRSIDTAAAY---KNEEGVGKAL 61 + G + LGLG W Q ++E + A + G DTA Y K E +G + Sbjct: 10 KSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 69 Query: 62 KNASVNREELFITTKLWND---------DHKRPREALLDSLKKLQLDYIDLYLMHWPVPA 112 K R L ITTK++ K E L SL++LQL+Y+D+ + P P Sbjct: 70 KKKGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN 129 Query: 113 IDHYVEAWKGMIELQKEGLIKSIGVCN------FQIHHLQRLIDETGVTPVINQIELHPL 166 E + M + +G+ G + + + R + + P+ Q E H Sbjct: 130 TPME-ETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNL--IPPICEQAEYHMF 186 Query: 167 MQQR-QLHAWNATHKI--QTESWSPLAQG 192 +++ ++ HKI +WSPLA G Sbjct: 187 QREKVEVQLPELFHKIGVGAMTWSPLACG 215 >4EXA-A nrPDB Length = 292 Score = 43.5 bits (101), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 48/194 (24%), Positives = 82/194 (42%), Gaps = 21/194 (10%) Query: 27 NEEVITAIQKALEVGYRSIDTAAAY-KNEEGVGKALKN-------ASVNREELFITTKLW 78 + E + A ++G IDTA AY ++EE +G L+ S EE ++ Sbjct: 69 DREAADLLALARDLGINLIDTAPAYGRSEERLGPLLRGQREHWVIVSKVGEEFVDGQSVF 128 Query: 79 NDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAID--HYVEAWKGMIELQKEGLIKSIG 136 + R ++ SLK+L+ D I+L L+H +D E + + L++EGLI + G Sbjct: 129 DFSAAHTRRSVERSLKRLETDRIELVLVHSDGNDLDILENSEVYPTLAALKREGLIGAYG 188 Query: 137 VCNFQIHHLQRLI---DETGVTPVINQIELHPLMQQRQLH--------AWNATHKIQTES 185 + + R + D VT +N+ P+++ H A + H Sbjct: 189 LSGKTVEGGLRALREGDCAMVTYNLNERAERPVIEYAAAHAKGILVKKALASGHACLGAG 248 Query: 186 WSPLAQGGKGVFDQ 199 P+ + VFDQ Sbjct: 249 QDPVRASFELVFDQ 262 >3N6Q-A nrPDB Length = 346 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 40/171 (23%) Query: 10 QDGNVMPQLGLGVWQASN-----EEVITAIQKALEVGYRSIDTAAAY-----KNEEGVGK 59 + G +P L LG+W E ++KA ++G D A Y EE G+ Sbjct: 20 KSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 60 ALK-NASVNREELFITTKLWNDDHKRP------REALL----DSLKKLQLDYIDLYLMHW 108 L+ + + R+EL I+TK D P R+ LL SLK++ L+Y+D++ H Sbjct: 80 LLREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHR 139 Query: 109 ---------PVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLID 150 A+ H V++ K + +G+ ++ Q++++ Sbjct: 140 VDENTPMEETASALAHAVQSGKALY----------VGISSYSPERTQKMVE 180 >1GVE-A nrPDB Length = 327 Score = 34.7 bits (78), Expect = 0.044, Method: Compositional matrix adjust. Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 21/177 (11%) Query: 33 AIQKALEVGYRSIDTAAAYKN---EEGVGKALKNASVNREELFITTK---LWNDDHKRP- 85 +++ L+ G+ IDTA Y N E +G + ++ I TK ++ K Sbjct: 27 SVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKVKIATKAAPMFGKTLKPAD 86 Query: 86 -REALLDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWKGMIELQKEGLIKSIGVCNF- 140 R L SLK+LQ +DL+ +H+P DH E + +L +EG +G+ N+ Sbjct: 87 VRFQLETSLKRLQCPRVDLFYLHFP----DHGTPIEETLQACHQLHQEGKFVELGLSNYV 142 Query: 141 --QIHHLQRLIDETG-VTPVINQIELHPLMQQRQLHAWNATHK--IQTESWSPLAQG 192 ++ + L + G + P + Q + + +Q + + ++ +++PLA G Sbjct: 143 SWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGG 199 >2CLP-A nrPDB Length = 347 Score = 34.3 bits (77), Expect = 0.063, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 89/202 (44%), Gaps = 33/202 (16%) Query: 33 AIQKA-LEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTK---LWNDDHK-- 83 A+ +A LE G+ IDTA Y ++E +G + + I TK L+ + K Sbjct: 46 AVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPD 105 Query: 84 RPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWKGMIELQKEGLIKSIGVCNF 140 R L SLK+LQ +DL+ +H P DH E + +L +EG +G+ N+ Sbjct: 106 SLRFQLETSLKRLQCPRVDLFYLHMP----DHSTPVEETLRACHQLHQEGKFVELGLSNY 161 Query: 141 ---QIHHLQRLIDETG-VTPVINQIELHPLMQQRQLHAWNATHK--IQTESWSPLAQG-- 192 ++ + L G + P + Q + + +Q + + ++ +++PLA G Sbjct: 162 AAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLL 221 Query: 193 -GKGVFDQKVIRDLADKYGKTP 213 GK ++ DK GK P Sbjct: 222 TGKYKYE--------DKDGKQP 235 >2C91-A nrPDB Length = 338 Score = 34.3 bits (77), Expect = 0.064, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 19/142 (13%) Query: 34 IQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKL--WNDDHKRP--- 85 ++ LE G+ +DTA Y ++E +G + I TK W +P Sbjct: 39 VRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSI 98 Query: 86 REALLDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWKGMIELQKEGLIKSIGVCNF-- 140 R L SLK+LQ +DL+ +H P DH E +L +EG +G+ N+ Sbjct: 99 RSQLETSLKRLQCPRVDLFYLHAP----DHSTPVEETLCACHQLHQEGKFVELGLSNYAS 154 Query: 141 -QIHHLQRLIDETG-VTPVINQ 160 ++ + L G + P + Q Sbjct: 155 WEVAEICTLCKSNGWILPTVYQ 176 >2BP1-A nrPDB Length = 360 Score = 33.9 bits (76), Expect = 0.076, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 81/205 (39%), Gaps = 50/205 (24%) Query: 38 LEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKL--WNDDHKRP---REAL 89 LE G+ +DTA Y ++E +G + I TK W+ +P R L Sbjct: 65 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 124 Query: 90 LDSLKKLQLDYIDLYLMHWPVPAIDHYV---EAWKGMIELQKEGLIKSIGVCNF---QIH 143 SLK+LQ +DL+ +H P DH E L +EG +G+ N+ ++ Sbjct: 125 ETSLKRLQCPQVDLFYLHAP----DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVA 180 Query: 144 HLQRLIDETG-VTPVINQ-----------IELHPLMQQRQLHAWNATHKIQTESWSPLAQ 191 + L G + P + Q EL P ++ L + +++PLA Sbjct: 181 EICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY---------AYNPLAG 231 Query: 192 G---GKGVFDQKVIRDLADKYGKTP 213 G GK ++ DK GK P Sbjct: 232 GLLTGKYKYE--------DKDGKQP 248 >3T6Z-A nrPDB Length = 495 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 27/68 (39%), Gaps = 1/68 (1%) Query: 174 AWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSV 233 A N+T W + G GV D IR D G I WHLD+G ++ Sbjct: 412 ASNSTSNYDDPIWRDVVSIG-GVGDNVTIRFCTDNPGPWFLHCHIDWHLDAGFAIVFAED 470 Query: 234 TPSRIAEN 241 P+ + N Sbjct: 471 IPNTASAN 478 >6MFL-A nrPDB Length = 308 Score = 27.7 bits (60), Expect = 5.0, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%) Query: 81 DHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKEGLI 132 DH R A+LD + LD +++ +M P + H++E +K ++Q G I Sbjct: 31 DHLPQRVAVLDMNEADFLDQLNVPIMGMPKDYVPHFLEKYKKDAQIQDLGAI 82 >3VS9-A nrPDB Length = 410 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 7/56 (12%) Query: 200 KVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE-NFDVWDFRLDKDEL 254 K +++ DKY +PAQI R LV PK +T R + NFD+ D D+ L Sbjct: 59 KTVKEKFDKYAVSPAQIKQRQ-----LVYFPK-LTDIRFGDGNFDIADPEPDQAHL 108 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1MZR-A nrPDB 435 e-122 4GIE-A nrPDB 401 e-112 1ZUA-X nrPDB 395 e-110 1VBJ-A nrPDB 394 e-110 4JQA-A nrPDB 388 e-108 2ALR-A nrPDB 384 e-107 4F40-A nrPDB 383 e-107 4GAC-A nrPDB 381 e-106 1HQT-A nrPDB 381 e-106 1Q5M-A nrPDB 378 e-105 5JM5-A nrPDB 376 e-105 2FVL-A nrPDB 373 e-104 3H7U-A nrPDB 369 e-103 5UXF-A nrPDB 364 e-101 3RX4-A nrPDB 363 e-101 2HE8-A nrPDB 363 e-101 1VP5-A nrPDB 361 e-100 1C9W-A nrPDB 359 e-100 3D3F-A nrPDB 359 e-100 1DLA-A nrPDB 358 1e-99 1FRB-A nrPDB 358 2e-99 4OTK-A nrPDB 357 3e-99 3G1R-A nrPDB 357 3e-99 5JH1-A nrPDB 357 3e-99 1AFS-A nrPDB 356 8e-99 3O3R-A nrPDB 352 9e-98 3H7R-A nrPDB 352 1e-97 4MHB-A nrPDB 352 1e-97 4HBK-A nrPDB 351 2e-97 3WCZ-A nrPDB 345 1e-95 5Z6T-A nrPDB 345 2e-95 2BGQ-A nrPDB 344 2e-95 5ZCM-A nrPDB 343 4e-95 1A80-A nrPDB 341 2e-94 1K8C-A nrPDB 340 4e-94 1QWK-A nrPDB 324 3e-89 3KRB-A nrPDB 312 1e-85 3UP8-A nrPDB 304 3e-83 4IJC-A nrPDB 302 1e-82 3WG6-A nrPDB 284 2e-77 4H8N-A nrPDB 276 8e-75 1PYF-A nrPDB 200 8e-52 4R9O-A nrPDB 199 1e-51 1OG6-A nrPDB 195 2e-50 3EB3-A nrPDB 181 3e-46 1PZ1-A nrPDB 169 1e-42 3N6Q-A nrPDB 156 8e-39 1LQA-A nrPDB 147 5e-36 4EXA-A nrPDB 139 1e-33 Sequences not found previously or not previously below threshold: 1GVE-A nrPDB 75 3e-14 2BP1-A nrPDB 75 3e-14 2CLP-A nrPDB 75 3e-14 2C91-A nrPDB 71 4e-13 2OHJ-A nrPDB 32 0.36 2YZ5-A nrPDB 31 0.73 4L1C-A nrPDB 30 0.95 4YMI-A nrPDB 30 1.0 5WSO-A nrPDB 30 1.3 2B3Y-A nrPDB 30 1.3 4L6H-A nrPDB 30 1.4 4EHI-A nrPDB 29 1.5 3QLD-A nrPDB 29 2.3 6C95-A nrPDB 29 2.8 3Q3N-A nrPDB 28 4.8 4X3Q-A nrPDB 28 6.5 6N2G-A nrPDB 27 7.8 >1MZR-A nrPDB Length = 296 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 274/275 (99%), Positives = 275/275 (100%) Query: 1 MANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 60 +ANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA Sbjct: 22 LANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 81 Query: 61 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 120 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW Sbjct: 82 LKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 141 Query: 121 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 180 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK Sbjct: 142 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 201 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE Sbjct: 202 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 261 Query: 241 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 275 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG Sbjct: 262 NFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 296 >4GIE-A nrPDB Length = 290 Score = 401 bits (1032), Expect = e-112, Method: Composition-based stats. Identities = 123/276 (44%), Positives = 179/276 (64%), Gaps = 6/276 (2%) Query: 2 ANPTVIKLQDGNVMPQLGLGVWQASNE-EVITAIQKALEVGYRSIDTAAAYKNEEGVGKA 60 N + L + MPQLGLGVW+A + E A++ A+E GYR IDTA Y NE GVG+ Sbjct: 11 CNYNCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQG 70 Query: 61 LKNASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVE 118 ++ + V REE+++TTK+WN D +++ A S + L L+YIDLYL+HWP +V+ Sbjct: 71 IRESGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP--GKKKFVD 128 Query: 119 AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNAT 178 WK + +L +E +++IGV NF+ HHL L + P++NQ+ELHPL QQR L + Sbjct: 129 TWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMVNQVELHPLFQQRTLREFCKQ 188 Query: 179 HKIQTESWSPLAQGGK-GVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSR 237 H I +WSPL G + G+ V+ ++A K+ K+PAQ+VIRW + G+V IPKS R Sbjct: 189 HNIAITAWSPLGSGEEAGILKNHVLGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGR 248 Query: 238 IAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 I ENF+VWDF+L ++E+ +I +L++ KR+G DPD F Sbjct: 249 IQENFNVWDFKLTEEEMRQIDELNEDKRIGADPDNF 284 >1ZUA-X nrPDB Length = 317 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 106/296 (35%), Positives = 171/296 (57%), Gaps = 34/296 (11%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 T ++L MP +GLG W++ +V A++ A++ GYR ID A Y+NE VG+A++ Sbjct: 3 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 64 A----SVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP-------- 109 +V RE+LFI +KLW +RP R+A +LK L+L Y+D+YL+HWP Sbjct: 63 KIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDD 122 Query: 110 -VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 P D +++AW+ M EL EGL+K++GV NF +++L+++ G+ PV Sbjct: 123 LFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPV 182 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKY 209 NQ+E HP + Q +L + + I ++SPL + + + I+++A K+ Sbjct: 183 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKH 242 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ ++VIPKSVTP+RI EN V+DF+L +E+ I ++ R Sbjct: 243 KKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWR 298 >1VBJ-A nrPDB Length = 281 Score = 394 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 117/276 (42%), Positives = 175/276 (63%), Gaps = 7/276 (2%) Query: 1 MANPTVIKLQDGNVMPQLGLGVWQASNE-EVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MA +KL +G +MP LG G+W+ + E TA A++ GYR IDTAA YKNEE G+ Sbjct: 6 MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGR 65 Query: 60 ALKNASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYV 117 A+ + V REELF+TTKLWN D ++ A S+KKL L+Y+DLYL+HWP D ++ Sbjct: 66 AIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWP--GKDKFI 123 Query: 118 EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNA 177 + WK +L + +++IGV NF HH++ L+ V P++NQIELHPL+ Q+ L + Sbjct: 124 DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCK 183 Query: 178 THKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSR 237 + I +WSPL QG + + ++ + KYGKT AQ+++RW + +G++ IPKS +R Sbjct: 184 SKNIAVTAWSPLGQG--HLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEAR 241 Query: 238 IAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 I EN +++DF L +++ I ++ G R GPDP+ F Sbjct: 242 IKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPEVF 277 >4JQA-A nrPDB Length = 331 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 105/312 (33%), Positives = 161/312 (51%), Gaps = 39/312 (12%) Query: 2 ANPTVIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVG 58 + +KL DG+ MP LG G + + + + A++ A+E G+ ID+A Y NEE VG Sbjct: 3 SKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVG 62 Query: 59 KALK----NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPA 112 A++ + SV RE++F T+KLW++ H + R AL SLK LQLDY+DLYL+H+PV Sbjct: 63 LAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSV 122 Query: 113 ID------------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGV 154 W+ M + + GL KSIGV NF L+ ++++ G+ Sbjct: 123 KPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGL 182 Query: 155 T--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIR 203 PV NQ+E HP QR+L + + I ++S L + + V+ Sbjct: 183 KYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLC 242 Query: 204 DLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQG 263 LA K+ +TPA I +R+ L G+VV+ KS RI +N V++F+L +E+ I L++ Sbjct: 243 ALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRN 302 Query: 264 KRLGPDPDQFGG 275 R D F G Sbjct: 303 VRYLT-LDIFAG 313 >2ALR-A nrPDB Length = 324 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 105/297 (35%), Positives = 161/297 (54%), Gaps = 33/297 (11%) Query: 3 NPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 + + L G MP +GLG W++ +V A++ AL VGYR ID AA Y NE +G+ALK Sbjct: 1 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 63 N-----ASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAI-- 113 +V REELF+T+KLWN H + AL +L LQL+Y+DLYLMHWP Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 114 ----------------DHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPV 157 HY E WK + L +GL++++G+ NF + ++ V P Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 180 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG--------KGVFDQKVIRDLADKY 209 + Q+E HP + Q +L A ++ ++SPL + ++ V+ LA+KY Sbjct: 181 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 240 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 G++PAQI++RW + ++ IPKS+TPSRI +N V+DF +E+ ++ L++ R Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 297 >4F40-A nrPDB Length = 288 Score = 383 bits (984), Expect = e-107, Method: Composition-based stats. Identities = 122/277 (44%), Positives = 174/277 (62%), Gaps = 11/277 (3%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVIT-AIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 ++ L +G MPQ GLGVWQ+ EV A++ AL GYR IDTAA YKNEE VG L+ Sbjct: 11 AMVTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRA 70 Query: 64 ASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAI------DH 115 + V RE++FITTKLWN + ++ A +S +KL +DYIDLYL+HWP Sbjct: 71 SGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPRGKDILSKEGKK 130 Query: 116 YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW 175 Y+++W+ +L KE +++IGV NF IHHL+ ++ VTP++NQ+ELHPL Q L A+ Sbjct: 131 YLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMVNQVELHPLNNQADLRAF 190 Query: 176 NATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTP 235 +I+ E+WSPL QG + ++ + KY KT AQ+++RW++ L+ IPKSV Sbjct: 191 CDAKQIKVEAWSPLGQGK--LLSNPILSAIGAKYNKTAAQVILRWNIQKNLITIPKSVHR 248 Query: 236 SRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQ 272 RI EN D++DF L +++ I L+ R GPDPD+ Sbjct: 249 ERIEENADIFDFELGAEDVMSIDALNTNSRYGPDPDE 285 >4GAC-A nrPDB Length = 324 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 103/296 (34%), Positives = 160/296 (54%), Gaps = 33/296 (11%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 + + L G MP +GLG W++ +V AI+ AL GYR ID A+ Y NE +G+ALK Sbjct: 2 ASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKE 61 Query: 64 A-----SVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAI--- 113 + +V REELF+T+KLWN H + AL +L LQL+Y+DLYLMHWP Sbjct: 62 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 121 Query: 114 ---------------DHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVI 158 HY E WK + L +GL+K++G+ NF + ++ V P + Sbjct: 122 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAV 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG--------KGVFDQKVIRDLADKYG 210 Q+E HP + Q +L A ++ ++SPL + ++ V+ LA+K+G Sbjct: 182 LQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHG 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 ++PAQI++RW + ++ IPKS+ PSRI +N V+DF +E+ ++ L++ R Sbjct: 242 RSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 297 >1HQT-A nrPDB Length = 326 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 103/297 (34%), Positives = 161/297 (54%), Gaps = 33/297 (11%) Query: 3 NPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 + + L G MP +GLG W++ +V AI+ AL VGYR ID AA + NE +G+AL+ Sbjct: 3 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEALQ 62 Query: 63 N-----ASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVP---- 111 +V REELF+T+KLWN H + AL +L LQL+Y+DLYLMHWP Sbjct: 63 ETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 122 Query: 112 --------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPV 157 HY + WK + L +GL++++G+ NF + ++ V P Sbjct: 123 DNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRPA 182 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG--------KGVFDQKVIRDLADKY 209 + Q+E HP + Q +L A ++ ++SPL + ++ V++ LA+KY Sbjct: 183 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKY 242 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 ++PAQI++RW + ++ IPKSVTPSRI +N V+DF +E+ ++ L++ R Sbjct: 243 NRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRF 299 >1Q5M-A nrPDB Length = 322 Score = 378 bits (972), Expect = e-105, Method: Composition-based stats. Identities = 100/298 (33%), Positives = 161/298 (54%), Gaps = 38/298 (12%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 + L DG+ +P LG G + + + + A + A++ G+R ID+A YKNE+ VG A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 ---NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP-------- 109 + +V RE++F T+KLW H + R +L DSLK LQLDY+DLY++H+P Sbjct: 67 KIADGTVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGVE 126 Query: 110 -VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 +P +H W+ M + + GL KSIGV NF L+ ++++ G+ PV Sbjct: 127 IIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPV 186 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLADK 208 NQ+E HP + Q +L + + I ++S L Q + + +I LA K Sbjct: 187 CNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAKK 246 Query: 209 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 + +TPA I +R+ L G+VV+ KS T RI EN V++F+L +++ I L++ R Sbjct: 247 HQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRY 304 >5JM5-A nrPDB Length = 332 Score = 376 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 100/308 (32%), Positives = 156/308 (50%), Gaps = 39/308 (12%) Query: 5 TVIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL 61 +KL DG+ MP LG G + + + + + A+E G+R ID+A Y NEE VG A+ Sbjct: 6 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAI 65 Query: 62 K----NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAID- 114 + + SV RE++F T+KLW+ H + R AL +SLKK QLDY+DLYL+H P+ Sbjct: 66 RSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125 Query: 115 -----------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT-- 155 W+ M + + GL KSIGV NF L+ ++++ G+ Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185 Query: 156 PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLA 206 PV NQ+E HP + +L + + I ++S L + + V+ LA Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245 Query: 207 DKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 K+ +TPA I +R+ L G+VV+ KS RI +N V++F+L +++ I LD+ Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHY 305 Query: 267 GPDPDQFG 274 + D F Sbjct: 306 F-NSDSFA 312 >2FVL-A nrPDB Length = 324 Score = 373 bits (957), Expect = e-104, Method: Composition-based stats. Identities = 97/298 (32%), Positives = 152/298 (51%), Gaps = 38/298 (12%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 ++L DG+ MP LG G + + + + A+E G+R ID+A Y NEE VG A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 ---NASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAID--- 114 + SV RE++F T+KLW + + AL SLKKLQLDY+DLYL+H+P+ Sbjct: 69 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 128 Query: 115 ---------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 W+ M + + GL KSIGV NF L+ ++++ G+ PV Sbjct: 129 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKPV 188 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLADK 208 NQ+E HP + Q +L + + I + S L + + V+ LA K Sbjct: 189 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 248 Query: 209 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 + +TPA I +R+ L G+VV+ KS RI EN V++F+L +++ + L++ R Sbjct: 249 HKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 306 >3H7U-A nrPDB Length = 335 Score = 369 bits (948), Expect = e-103, Method: Composition-based stats. Identities = 109/291 (37%), Positives = 154/291 (52%), Gaps = 25/291 (8%) Query: 1 MANP-TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MAN T KL G P +GLG WQAS V A+ A+++GYR ID A Y NE+ +G Sbjct: 21 MANAITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGA 80 Query: 60 ALK----NASVNREELFITTKLWNDDHK--RPREALLDSLKKLQLDYIDLYLMHWPVPAI 113 LK + V RE+LFIT+KLW DH EAL +LK LQL+Y+DLYL+HWP Sbjct: 81 VLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIK 140 Query: 114 DHYV-------------EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160 V WK M L G ++IGV NF L L++ V P +NQ Sbjct: 141 KGSVGIKPENLLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPAVNQ 200 Query: 161 IELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG-----VFDQKVIRDLADKYGKTPAQ 215 +E HP +Q +L + + + ++SPL G V ++ +A+K GK+PAQ Sbjct: 201 VECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSDVLKNPILNMVAEKLGKSPAQ 260 Query: 216 IVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 + +RW L G V+PKS RI ENF+V+D+ + + A+++Q + + Sbjct: 261 VALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIEQARLV 311 >5UXF-A nrPDB Length = 342 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 98/301 (32%), Positives = 162/301 (53%), Gaps = 38/301 (12%) Query: 6 VIKLQDGNVMPQLGLGVWQ---ASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 +KL DG+++P LG G ++ + + A AL+VGYR +DTA AY+ EE +G+A++ Sbjct: 26 CVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQ 85 Query: 63 N----ASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVP----- 111 + V RE+LF+TTKLW + + AL SLKKLQLDY+DLY+MH+PVP Sbjct: 86 SAIAAGVVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGD 145 Query: 112 -------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 + + W+ + E + GL+KSIGV NF L+R++++ G+ P Sbjct: 146 NDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKP 205 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLAD 207 V NQ+E H + QR+L + + I ++ L Q + + V+ D+A Sbjct: 206 VCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAK 265 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLG 267 K ++PA I +R+ + G+V + +S + + EN V+ F+L +++ + L++ R Sbjct: 266 KNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRYL 325 Query: 268 P 268 P Sbjct: 326 P 326 >3RX4-A nrPDB Length = 336 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 107/297 (36%), Positives = 166/297 (55%), Gaps = 34/297 (11%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL-- 61 + + L +G MP LGLG W++ +V A++ A++VGYR ID A Y+NE VG A+ Sbjct: 22 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 81 Query: 62 --KNASVNREELFITTKLWNDDHKR--PREALLDSLKKLQLDYIDLYLMHWP-------- 109 + V REELFI +KLW H++ + A +L L+LDY+DLYL+HWP Sbjct: 82 KLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKE 141 Query: 110 ----------VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 VP+ + ++ W M EL EGL+K+IG+ NF ++ ++++ G+ P Sbjct: 142 FFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPA 201 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKY 209 +NQIE HP + Q +L + + I ++SPL + + + I+ +A K+ Sbjct: 202 VNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKH 261 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 KT AQ++IR+ + LVVIPKSVTP RIAENF V+DF L ++ + ++ R+ Sbjct: 262 NKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRV 318 >2HE8-A nrPDB Length = 323 Score = 363 bits (931), Expect = e-101, Method: Composition-based stats. Identities = 91/301 (30%), Positives = 154/301 (51%), Gaps = 38/301 (12%) Query: 6 VIKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 + L DGN +P LG G + + + A++ G+ D+A+ Y E+ VG+A++ Sbjct: 7 CVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIR 66 Query: 63 ----NASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPV------ 110 + +V RE++F T+K+W + R +L SL+KLQ DY+DLYL+H+P+ Sbjct: 67 SKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGE 126 Query: 111 ---PAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 P +H W+ M + + GL KSIGV NF L+ ++++ G+ P Sbjct: 127 ENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKP 186 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIRDLAD 207 V NQ+E HP + Q +L + + I ++ L Q + D+ V+ +A Sbjct: 187 VCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMAK 246 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLG 267 KY +TPA I +R+ L G+VV+ S+ RI EN V++F+L +++ + L++ R Sbjct: 247 KYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYI 306 Query: 268 P 268 P Sbjct: 307 P 307 >1VP5-A nrPDB Length = 298 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 118/264 (44%), Positives = 172/264 (65%), Gaps = 9/264 (3%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK---- 62 + L +G MP LG GV+Q E+ + +A++VGYR IDTAA+Y NEEGVG+A+K Sbjct: 18 VTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAIKRAID 77 Query: 63 NASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAW 120 V REELF+TTKLW D ++ ++A SLKKLQL+YIDLYL+H P + AW Sbjct: 78 EGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFGDVHC---AW 134 Query: 121 KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHK 180 K M E+ K+GL+++IGV NF L L+ + P +NQIE+HP Q+++ + + Sbjct: 135 KAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVPAVNQIEIHPFYQRQEEIEFMRNYN 194 Query: 181 IQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240 IQ E+W P A+G K +F V+R +A+KYGKT AQ+++RW G+V IPK+V R+ E Sbjct: 195 IQPEAWGPFAEGRKNIFQNGVLRSIAEKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKE 254 Query: 241 NFDVWDFRLDKDELGEIAKLDQGK 264 N ++DF L ++++ +IA LD+G+ Sbjct: 255 NISIFDFELTQEDMEKIATLDEGQ 278 >1C9W-A nrPDB Length = 315 Score = 359 bits (922), Expect = e-100, Method: Composition-based stats. Identities = 112/302 (37%), Positives = 171/302 (56%), Gaps = 34/302 (11%) Query: 5 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL--- 61 T ++L MP +GLG WQ+ +V A++ A++ GYR ID A AY NE VG+A+ Sbjct: 2 TFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQEK 61 Query: 62 -KNASVNREELFITTKLWNDDHKR--PREALLDSLKKLQLDYIDLYLMHWP--------- 109 K +V RE+LFI +KLW +R +EA +L L+LDY+DLYL+HWP Sbjct: 62 IKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKEL 121 Query: 110 VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVI 158 P D +++AW+ M EL EGL+K++GV NF ++R++++ G+ PV Sbjct: 122 FPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPVT 181 Query: 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQG--------GKGVFDQKVIRDLADKYG 210 NQ+E HP + Q +L + + I ++SPL + + I+++A K+ Sbjct: 182 NQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAKHK 241 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDP 270 KT AQ++IR+H+ +VVIPKSVTP+RI ENF V+DF+L E+ I ++ R P Sbjct: 242 KTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACLLP 301 Query: 271 DQ 272 + Sbjct: 302 ET 303 >3D3F-A nrPDB Length = 275 Score = 359 bits (921), Expect = e-100, Method: Composition-based stats. Identities = 122/271 (45%), Positives = 187/271 (69%), Gaps = 7/271 (2%) Query: 6 VIKLQDGNVMPQLGLGVWQASNE-EVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 64 +KL +G MP GLGV++ N E +++ A++ GYRSIDTAA YKNEEGVG +K + Sbjct: 7 TVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKES 66 Query: 65 SVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKG 122 V REELFIT+K+WN+D ++ A SL++LQLDY+DLYL+HWP D Y + W+ Sbjct: 67 GVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP--GKDKYKDTWRA 124 Query: 123 MIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQ 182 + +L K+G I++IGV NFQ+HHL+ L+ + + P++NQ+E HP + Q++L + IQ Sbjct: 125 LEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVNQVEFHPRLTQKELRDYCKGQGIQ 184 Query: 183 TESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENF 242 E+WSPL QG + D +V+ +A+K+ K+ AQ+++RW L G+V IPKS+ RI EN Sbjct: 185 LEAWSPLMQGQ--LLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENA 242 Query: 243 DVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 D++DF L ++++ +I L++ +R+GP+PD+ Sbjct: 243 DIFDFELSQEDMDKIDALNKDERVGPNPDEL 273 >1DLA-A nrPDB Length = 314 Score = 358 bits (919), Expect = 1e-99, Method: Composition-based stats. Identities = 109/292 (37%), Positives = 167/292 (57%), Gaps = 34/292 (11%) Query: 9 LQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA---- 64 L G MP LGLG W++ +V A++ A+++GYR ID A Y+NE VG L+ Sbjct: 5 LYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQ 64 Query: 65 SVNREELFITTKLWNDDHKR--PREALLDSLKKLQLDYIDLYLMHWP------------- 109 V RE+LFI +KLW DH++ + A +L+ L+LDY+DLYL+HWP Sbjct: 65 VVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLD 124 Query: 110 -----VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVINQIE 162 VP +VE W+ M EL EGL+K+IGV NF +++++++ G+ P +NQIE Sbjct: 125 GDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIE 184 Query: 163 LHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYGKTPA 214 +HP + Q +L + + I ++SPL + + + I+ +A KY KT A Sbjct: 185 VHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTA 244 Query: 215 QIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 Q++IR+ + L+VIPKSVTP RIAENF V+DF L +++ + ++ R+ Sbjct: 245 QVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRV 296 >1FRB-A nrPDB Length = 315 Score = 358 bits (918), Expect = 2e-99, Method: Composition-based stats. Identities = 112/303 (36%), Positives = 173/303 (57%), Gaps = 34/303 (11%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL-- 61 T ++L MP +GLG W++ +V A++ A++ GYR ID A AY NE VG+A+ Sbjct: 1 ATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 62 --KNASVNREELFITTKLWNDDHKR--PREALLDSLKKLQLDYIDLYLMHWP-------- 109 K +V RE+LFI +KLW ++ +EA +L L+LDY+DLYL+HWP Sbjct: 61 KIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKE 120 Query: 110 -VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 P D ++EAW+GM EL +GL+K++GV NF ++RL+++ G+ PV Sbjct: 121 LFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 180 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKY 209 NQ+E HP + Q +L + + I ++SPL + + + I+++A K+ Sbjct: 181 TNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAKH 240 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPD 269 KT AQ++IR+H+ +VVIPKSVTPSRI EN V+DF+L +E+ I ++ R Sbjct: 241 EKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLL 300 Query: 270 PDQ 272 P+ Sbjct: 301 PET 303 >4OTK-A nrPDB Length = 318 Score = 357 bits (917), Expect = 3e-99, Method: Composition-based stats. Identities = 130/276 (47%), Positives = 175/276 (63%), Gaps = 4/276 (1%) Query: 2 ANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL 61 A I L D + MP LGLGV + S++E A+ ALE+G R IDTA AY NE VG+A+ Sbjct: 44 AAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAI 103 Query: 62 KNASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEA 119 + V REELF+TTKL D R +EA SL +L LDY+DLYL+HWP P + YV+A Sbjct: 104 AASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVGKYVDA 163 Query: 120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATH 179 W GMI+ + EG +SIGV NF +++ LID T VTP +NQIELHPL+ Q +L NA H Sbjct: 164 WGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQH 223 Query: 180 KIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIA 239 + T+S+ PLA G + D + +A +Y KTPAQ+++RW+L G V+ +S P RIA Sbjct: 224 TVVTQSYCPLALGR--LLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIA 281 Query: 240 ENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG 275 NFDV+DF L + + + L+ G R+ DP + G Sbjct: 282 SNFDVFDFELAAEHMDALGGLNDGTRVREDPLTYAG 317 >3G1R-A nrPDB Length = 346 Score = 357 bits (917), Expect = 3e-99, Method: Composition-based stats. Identities = 97/299 (32%), Positives = 152/299 (50%), Gaps = 39/299 (13%) Query: 7 IKLQDGNVMPQLGLGVWQASNEE----VITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 62 I L DGN +P +GLG + T+++ A++ GYR ID A Y+NE VG+A++ Sbjct: 30 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 89 Query: 63 N----ASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAID-- 114 V RE++F KLW +H + R L +L+ LQLDY+DLY++ P+ Sbjct: 90 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 149 Query: 115 ----------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 156 + W+ M + GL+KS+GV NF L+ ++++ G+ P Sbjct: 150 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 209 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG---------KGVFDQKVIRDLAD 207 V NQ+E HP Q +L + H I ++SPL + ++ L Sbjct: 210 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 269 Query: 208 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 +Y KT AQIV+R+++ G+VVIPKS RI ENF ++DF L ++E+ +I L++ R Sbjct: 270 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 328 >5JH1-A nrPDB Length = 309 Score = 357 bits (917), Expect = 3e-99, Method: Composition-based stats. Identities = 104/286 (36%), Positives = 153/286 (53%), Gaps = 23/286 (8%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK---- 62 L G +P +GLG WQ+ V A+ A++ GYR ID A Y NE+ +G ALK Sbjct: 4 FVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKLFE 63 Query: 63 NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV---------- 110 V RE++FIT+KLWND H + EAL DSL LQL+Y+DLYL+HWP Sbjct: 64 EGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNTSP 123 Query: 111 --PAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQ 168 + W M +L G ++IGV NF L L+ V P ++Q+E HP Q Sbjct: 124 ENFVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPGWQ 183 Query: 169 QRQLHAWNATHKIQTESWSPLAQGG-----KGVFDQKVIRDLADKYGKTPAQIVIRWHLD 223 Q +LH++ + + ++SPL G V + +I +A+K GKT AQ+ +RW++ Sbjct: 184 QTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGNVLKEPIIISIAEKLGKTSAQVALRWNIQ 243 Query: 224 SGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPD 269 G V+PKS RI +N DV+D+ + D L + +++ Q + L + Sbjct: 244 MGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQARLLRGN 289 >1AFS-A nrPDB Length = 323 Score = 356 bits (913), Expect = 8e-99, Method: Composition-based stats. Identities = 92/299 (30%), Positives = 156/299 (52%), Gaps = 38/299 (12%) Query: 7 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 62 + L DGN +P LG G + + +EVI A + A++ G+R D+A Y+ EE VG+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 ---NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV------- 110 + +V RE++F T+KLW+ H + R L +LK QLDY+DLY++H+P+ Sbjct: 68 KIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGDI 127 Query: 111 --PAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 P +H + W+ M + + GL KSIGV NF L+R++++ G+ PV Sbjct: 128 FFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKPV 187 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG---------KGVFDQKVIRDLADK 208 NQ+E H + Q ++ + + I S+ L + D V+ +A K Sbjct: 188 CNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAKK 247 Query: 209 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLG 267 Y +TPA + +R+ L G+V + +S RI E V++F+L +++ + L++ R Sbjct: 248 YKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN 306 >3O3R-A nrPDB Length = 316 Score = 352 bits (904), Expect = 9e-98, Method: Composition-based stats. Identities = 106/296 (35%), Positives = 170/296 (57%), Gaps = 34/296 (11%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL-- 61 T +KL+ MP +GLG W++ +V A++ A++ GYR D A Y+NE VG+A+ Sbjct: 2 TTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQE 61 Query: 62 --KNASVNREELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWP-------- 109 K +V RE+LFI +KLW+ ++ +EA +L L+LDY+DLYL+HWP Sbjct: 62 KIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE 121 Query: 110 -VPAIDH---------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 157 +P +++AW+GM EL +GL+K++GV NF ++RL+++ G+ PV Sbjct: 122 FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 181 Query: 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG--------KGVFDQKVIRDLADKY 209 NQ+E HP + Q +L + + I ++SPL V + I+++A K+ Sbjct: 182 TNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKH 241 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 KT AQ++IR+H+ + VIPKSVT S I EN V+DF+L ++++ I L++ R Sbjct: 242 KKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWR 297 >3H7R-A nrPDB Length = 331 Score = 352 bits (903), Expect = 1e-97, Method: Composition-based stats. Identities = 107/289 (37%), Positives = 160/289 (55%), Gaps = 29/289 (10%) Query: 1 MANPT-VIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK 59 MA P +L G +P +GLG + V TAI++A+++GYR ID A+ Y NE+ +G Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTY----AMVATAIEQAIKIGYRHIDCASIYGNEKEIGG 76 Query: 60 ALK----NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVP-- 111 LK + V REELFIT+KLW++DH + +AL +L+ LQ+DY+DLYL+HWP Sbjct: 77 VLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLK 136 Query: 112 -----------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQ 160 WK M L G ++IGV NF L L++ VTP +NQ Sbjct: 137 KESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQ 196 Query: 161 IELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG-----VFDQKVIRDLADKYGKTPAQ 215 +E HP+ QQ+ LH + + +SPL KG V ++ ++A+K GKT AQ Sbjct: 197 VECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQ 256 Query: 216 IVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 + +RW L +G V+PKS + +R+ EN DV+D+ + +D + + + Q K Sbjct: 257 VALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQEK 305 >4MHB-A nrPDB Length = 297 Score = 352 bits (903), Expect = 1e-97, Method: Composition-based stats. Identities = 110/260 (42%), Positives = 158/260 (60%), Gaps = 6/260 (2%) Query: 5 TVIKLQDGNVMPQLGLGVWQASN-EEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 63 +KL +G MP LG GV+Q +N E A+ A+E GYR IDTAA+Y+NE VG ALK Sbjct: 16 QTVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKL 75 Query: 64 ASVNREELFITTKLW--NDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWK 121 + + R+ELFITTKLW + ++ + SL +LQLDY+DLYL+H P + AW+ Sbjct: 76 SGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG---AWR 132 Query: 122 GMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKI 181 M EL + G I++IGV NF L L+ + P +NQIE++P QQ W + I Sbjct: 133 AMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVNQIEVNPFNQQLHAVPWMQSRGI 192 Query: 182 QTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAEN 241 Q E+W+P A+G G+F V+ + +KYGK+ Q+V+RW G+V + KSV R+ EN Sbjct: 193 QPEAWAPFAEGRNGLFQNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEEN 252 Query: 242 FDVWDFRLDKDELGEIAKLD 261 ++ DF L +++ +IA LD Sbjct: 253 INILDFELSAEDMLQIAALD 272 >4HBK-A nrPDB Length = 344 Score = 351 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 102/288 (35%), Positives = 165/288 (57%), Gaps = 29/288 (10%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNAS- 65 +K+ +G +P +GLG W + EV A++KALE+GYR +D A Y+NE +G+AL+NA Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALN 97 Query: 66 ---VNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDH----- 115 + RE++FIT+KLWN + R+A ++LK L+L+Y+DLYL+HWPVP Sbjct: 98 SLRLKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLFP 157 Query: 116 -------------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIE 162 + + WK M +L EGL+KSIG+ NF +Q +++ + P QIE Sbjct: 158 TDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQIE 217 Query: 163 LHPLMQQRQLHAWNATHKIQTESWSPLAQ-----GGKGVFDQKVIRDLADKYGKTPAQIV 217 +H +L + + + +++PL G + + + ++A ++ KTPAQ++ Sbjct: 218 IHANFPNIKLVEYAQSVGLTVTAYAPLGSPAHSPGKVNLLTKPCVLEIAHRHKKTPAQVL 277 Query: 218 IRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 265 +R+ L L+V+PKSVT RI ENF V+DF+L +E+ E+ +R Sbjct: 278 LRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNER 325 >3WCZ-A nrPDB Length = 308 Score = 345 bits (885), Expect = 1e-95, Method: Composition-based stats. Identities = 118/290 (40%), Positives = 169/290 (58%), Gaps = 27/290 (9%) Query: 4 PTVIKLQDGNVMPQLGLGVWQASN------EEVITAIQKALEVGYRSIDTAAAYKNEEGV 57 I+L DGN +P + LG + + +EV A+ A+E GYR IDTAA Y++EE V Sbjct: 5 APCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQV 64 Query: 58 G----KALKNASVNREELFITTKLWNDDHKRPR--EALLDSLKKLQLDYIDLYLMHWPV- 110 G +A+ N V REELF+TTKLWND H R + AL +SLKKL LDYIDLYL+H+P+ Sbjct: 65 GQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIA 124 Query: 111 ------PAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELH 164 P Y+E W+GM + ++ GL +SIGV NF + RL+ + + PVINQIE++ Sbjct: 125 TKPDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYIRPVINQIEVN 184 Query: 165 PLMQQRQLHAWNATHKIQTESWSPLA-------QGGKGV-FDQKVIRDLADKYGKTPAQI 216 P Q L A + I ++SP G D + LA+KY K+ QI Sbjct: 185 PTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTLTALANKYRKSVGQI 244 Query: 217 VIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 ++R+ +D GL+ IPKS RIA+N D++DF+L +E+ I + ++ R+ Sbjct: 245 LLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKNHRV 294 >5Z6T-A nrPDB Length = 343 Score = 345 bits (885), Expect = 2e-95, Method: Composition-based stats. Identities = 107/307 (34%), Positives = 157/307 (51%), Gaps = 43/307 (14%) Query: 6 VIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVG----KAL 61 IKL G MP +G G W+ + I +A++ GYR D A Y NE+ VG KA+ Sbjct: 28 SIKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKAI 87 Query: 62 KNASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV-----PAID 114 V RE+LF+T+KLWN+ H +AL +L LQ+DY+DL+L+H+PV P + Sbjct: 88 DEGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPLEE 147 Query: 115 HY-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT 155 Y +E WK + +L K G I+SIGV NF L L+ + Sbjct: 148 KYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGATIK 207 Query: 156 PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ------------GGKGVFDQKVIR 203 P + Q+E HP +QQ +L + + I ++S +F+ + I+ Sbjct: 208 PSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENETIK 267 Query: 204 DLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQG 263 +A K+GK+PAQ+++RW G+ +IPKS T R+ EN DV F LD+ + +IAKLD Sbjct: 268 AIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLDIN 327 Query: 264 KRLGPDP 270 R DP Sbjct: 328 LRFN-DP 333 >2BGQ-A nrPDB Length = 344 Score = 344 bits (883), Expect = 2e-95, Method: Composition-based stats. Identities = 102/286 (35%), Positives = 155/286 (54%), Gaps = 19/286 (6%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK---N 63 L+ G+ MP +GLG W+A ++ + E GYR +DTAA Y E+ VGK LK Sbjct: 40 FVLKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAME 99 Query: 64 ASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPV---------PA 112 A ++R++LF+T+K+W + +R R AL ++LK LQLDYIDLY +HWP P Sbjct: 100 AGIDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMPPE 159 Query: 113 IDHYVE-----AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLM 167 +E WK M L K+GL+K IGVCN+ + L RL+ + P + Q+E+HP Sbjct: 160 AGEVLEFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQMEMHPGW 219 Query: 168 QQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLV 227 + ++ H I ++SPL K + V+ +A+K KTP Q++I+W L G Sbjct: 220 KNDKIFEACKKHGIHITAYSPLGSSEKNLAHDPVVEKVANKLNKTPGQVLIKWALQRGTS 279 Query: 228 VIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQF 273 VIPKS RI EN V+ + + +++ + + KR+ + F Sbjct: 280 VIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLTGEELF 325 >5ZCM-A nrPDB Length = 341 Score = 343 bits (881), Expect = 4e-95, Method: Composition-based stats. Identities = 108/304 (35%), Positives = 151/304 (49%), Gaps = 42/304 (13%) Query: 6 VIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK----AL 61 IKL G MP +G G W+ N + A++VGYR D A Y N + +G+ AL Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRAL 82 Query: 62 KNASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP-----VPAID 114 V R+ELFIT+KLWN H K AL L ++LDYIDL+L+H+P VP + Sbjct: 83 DEGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPFEE 142 Query: 115 HY-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT 155 Y +E WK M +L K G KSIG+ NF + L+ + Sbjct: 143 KYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLRGAEIK 202 Query: 156 PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGG------------KGVFDQKVIR 203 P + QIE HP +QQ +L + + I ++S +F+ K I Sbjct: 203 PAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFEHKTIT 262 Query: 204 DLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQG 263 +ADKY KTPAQ+++RW + +IPKS P R+ +N +V DF L K++ EI+KLDQ Sbjct: 263 SIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEISKLDQD 322 Query: 264 KRLG 267 R Sbjct: 323 LRFN 326 >1A80-A nrPDB Length = 277 Score = 341 bits (876), Expect = 2e-94, Method: Composition-based stats. Identities = 139/272 (51%), Positives = 179/272 (65%), Gaps = 5/272 (1%) Query: 6 VIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNAS 65 I L DGN +PQLG GV++ + A+++ALEVGYR IDTAA Y NEEGVG A+ + Sbjct: 4 SIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGVGAAIAASG 63 Query: 66 VNREELFITTKLWNDDHKR--PREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGM 123 + R++LFITTKLWND H P A+ +SL KL LD +DLYL+HWP PA D+YV AW+ M Sbjct: 64 IARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTPAADNYVHAWEKM 123 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQT 183 IEL+ GL +SIGV N + HL+R++ TGV P +NQIELHP QQR++ W A H ++ Sbjct: 124 IELRAAGLTRSIGVSNHLVPHLERIVAATGVVPAVNQIELHPAYQQREITDWAAAHDVKI 183 Query: 184 ESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFD 243 ESW PL QG +F + + A +GKTPAQ V+RWHL G VV PKSV R+ EN D Sbjct: 184 ESWGPLGQGKYDLFGAEPVTAAAAAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLD 243 Query: 244 VWDFRLDKDELGEIAKLDQGK---RLGPDPDQ 272 V+DF L E+ I +D G R+ PD+ Sbjct: 244 VFDFDLTDTEIAAIDAMDPGDGSGRVSAHPDE 275 >1K8C-A nrPDB Length = 322 Score = 340 bits (872), Expect = 4e-94, Method: Composition-based stats. Identities = 105/306 (34%), Positives = 154/306 (50%), Gaps = 43/306 (14%) Query: 7 IKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVG----KALK 62 IKL G++MP +G G W+ +N + +A++ GYR D A Y NE+ VG +A+ Sbjct: 8 IKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGDGVKRAID 67 Query: 63 NASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWP-----VPAIDH 115 V REE+F+T+KLWN+ H K AL +L L++DY+DL+L+H+P VP + Sbjct: 68 EGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFKFVPIEEK 127 Query: 116 Y-------------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP 156 Y +E WK + +L G IKSIGV NF L L+ + P Sbjct: 128 YPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRGATIKP 187 Query: 157 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ------------GGKGVFDQKVIRD 204 + Q+E HP +QQ +L + + ++S +F I+ Sbjct: 188 AVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTLFAHDTIKA 247 Query: 205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK 264 +A KY KTPA++++RW G+ VIPKS P R+ +N F L K++ EIAKLD G Sbjct: 248 IAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEEIAKLDIGL 307 Query: 265 RLGPDP 270 R DP Sbjct: 308 RFN-DP 312 >1QWK-A nrPDB Length = 317 Score = 324 bits (831), Expect = 3e-89, Method: Composition-based stats. Identities = 111/297 (37%), Positives = 161/297 (54%), Gaps = 33/297 (11%) Query: 2 ANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL 61 + IKL +G MP +GLG WQ+S EVITA++ A++ GYR IDTA+ Y+NEE +G A+ Sbjct: 3 SATASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAI 62 Query: 62 K----NASVNREELFITTKLWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDH 115 K V REELFITTK W + + L +SLKKLQL+Y+DLYL H P D Sbjct: 63 KELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFNDD 122 Query: 116 YVE--------AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN-QIELHPL 166 E W+ + K GL K++GV N+ + R + G+TPV N Q+ELH Sbjct: 123 MSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALAL-GLTPVHNSQVELHLY 181 Query: 167 MQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKV-----------------IRDLADKY 209 Q + H I S++ L G+ F + LA+K Sbjct: 182 FPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPAPSDLQDQNVLALAEKT 241 Query: 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 266 KTPAQ+++R+ LD G ++PKS+ +RI ENF+V+DF L ++++ ++ + +RL Sbjct: 242 HKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEESKNSQRL 298 >3KRB-A nrPDB Length = 334 Score = 312 bits (800), Expect = 1e-85, Method: Composition-based stats. Identities = 95/302 (31%), Positives = 153/302 (50%), Gaps = 44/302 (14%) Query: 16 PQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKAL------KNASVNRE 69 P+LG G WQA E V TA++ AL GYR ID A Y+NEE +G+A ++ + RE Sbjct: 26 PRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSGIKRE 85 Query: 70 ELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAIDH------------ 115 +++IT+KLWN +H + RE ++ LQ+DY+DL+L+HWP+ + + Sbjct: 86 DVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKDAEG 145 Query: 116 --------YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLM 167 + W+ M +L +EGL+K IGV N+ + L L++ + P++NQIE+HP Sbjct: 146 RAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHPWH 205 Query: 168 QQRQLHAWNATHKIQTESWSPLAQG-----------GKGVFDQKVIRDLADKYGKTPAQI 216 + + I ++SP+ + + K ++ +AD G +P + Sbjct: 206 PNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKGTSPHCV 265 Query: 217 VIRWHLDS----GLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLG-PDPD 271 + WH+ VIPKS TP+RI NF + +L D++ I + KR+ DP Sbjct: 266 ALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFCDPA 325 Query: 272 QF 273 F Sbjct: 326 IF 327 >3UP8-A nrPDB Length = 298 Score = 304 bits (778), Expect = 3e-83, Method: Composition-based stats. Identities = 75/256 (29%), Positives = 146/256 (57%), Gaps = 6/256 (2%) Query: 10 QDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNRE 69 +G +P LG G ++ S EV+ + +AL++G+R +DTA Y NE VG+A++ + + R Sbjct: 29 SNGANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQKSGIPRA 88 Query: 70 ELFITTKLWNDDHKRP--REALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQ 127 ++F+TTK+W D+++ ++ +SL+KL+ D++DL L+HWP + E + E++ Sbjct: 89 DVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGSDVPM-AERIGALNEVR 147 Query: 128 KEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWS 187 G ++ IG+ NF ++ + NQ+E HP + Q ++ + S+ Sbjct: 148 NAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYHPYLDQTKVLQTARRLGMSLTSYY 207 Query: 188 PLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHL-DSGLVVIPKSVTPSRIAENFDVWD 246 +A G V ++ ++ ++GKT AQ+ +RW + ++V+ K+ T +R+ ENF ++D Sbjct: 208 AMANGK--VPADPLLTEIGGRHGKTAAQVALRWLVQQQDVIVLSKTATEARLKENFAIFD 265 Query: 247 FRLDKDELGEIAKLDQ 262 F L ++E+ + +L + Sbjct: 266 FALTREEMAAVRELAR 281 >4IJC-A nrPDB Length = 344 Score = 302 bits (773), Expect = 1e-82, Method: Composition-based stats. Identities = 100/302 (33%), Positives = 152/302 (50%), Gaps = 40/302 (13%) Query: 7 IKLQDGNVMPQLGLGVWQASN--EEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK-- 62 L +G +P LGLG E A++ A++ GYR IDTA AY+ E VG+A+K Sbjct: 25 FSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKEL 84 Query: 63 --NASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWP----------- 109 + S+ RE+LFITTK+W +L +SLK L L+Y+DL L HWP Sbjct: 85 LEDGSIKREDLFITTKVWPVLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKG 144 Query: 110 ----------------VPAIDHYVEAWKGMIELQ---KEGLIKSIGVCNFQIHHLQRLID 150 A Y+E +K + ++ + +++IGV NF I +L+RLI Sbjct: 145 ISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLIK 204 Query: 151 ETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYG 210 E V P +NQ+E HP + Q +L + H I ++SPL G +++ LA+KY Sbjct: 205 ECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKYN 264 Query: 211 KTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGK--RLGP 268 T ++I +H+ G +VIP+S+ P RI+ + + L KDEL E+ + R Sbjct: 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELNDFGEKYPVRFID 322 Query: 269 DP 270 +P Sbjct: 323 EP 324 >3WG6-A nrPDB Length = 307 Score = 284 bits (728), Expect = 2e-77, Method: Composition-based stats. Identities = 93/295 (31%), Positives = 156/295 (52%), Gaps = 28/295 (9%) Query: 7 IKLQDGNVMPQLGLGVWQAS--------NEEVITAIQKALEVGYRSIDTAAAYKNEEGVG 58 KL +GN +P + G ++++I ++ AL G+R ID A Y + +G Sbjct: 11 FKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGTNKEIG 70 Query: 59 KALKNASVNREELFITTKLWNDDH---------KRPREALLDSLKKLQLDYIDLYLMHWP 109 ALKN +NR+++FIT K + +H + P AL L+ L L+Y+DLYL+H+P Sbjct: 71 IALKNVGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVDLYLIHFP 130 Query: 110 VPAIDHY----VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLID-ETGVTPVINQIELH 164 + + VEAW+ + + EGL ++IGV NF I +L+ ++D T PV+NQIE Sbjct: 131 YISEKSHGFDLVEAWRYLERAKNEGLARNIGVSNFTIENLKSILDANTDSIPVVNQIEFS 190 Query: 165 PLMQQRQ--LHAWNATHKIQTESWSPLA---QGGKGVFDQKVIRDLADKYGKTPAQIVIR 219 +Q + + ++ I E++ PL QG G KV+ L++KY + QI++R Sbjct: 191 AYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRPGPL-DKVLSKLSEKYKRNEGQILLR 249 Query: 220 WHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFG 274 W L G++ I + RI + +++DF LDK++ +I K+ + K L ++ Sbjct: 250 WVLQRGILPITTTSKEERINDVLEIFDFELDKEDEDQITKVGKEKTLRQFSKEYS 304 >4H8N-A nrPDB Length = 310 Score = 276 bits (706), Expect = 8e-75, Method: Composition-based stats. Identities = 90/285 (31%), Positives = 156/285 (54%), Gaps = 26/285 (9%) Query: 4 PTVIKLQDGNVMP-QLGLGV-WQAS------NEEVITAIQKALEVGYRSIDTAAAYKNEE 55 P + + G + LG G W+ + + E++ I L++G+R IDTA AY ++ Sbjct: 11 PKTFRTKSGKEISIALGTGTKWKQAQTINDVSTELVDNILLGLKLGFRHIDTAEAYNTQK 70 Query: 56 GVGKALKNASVNREELFITTKL---WND---DHKRPREALLDSLKKLQLDYIDLYLMHWP 109 VG+ALK V RE++++TTK W K P +++ +L +L +DY+DL+L+H P Sbjct: 71 EVGEALKRTDVPREDIWVTTKYSPGWGSIKAYSKSPSDSIDKALAQLGVDYVDLFLIHSP 130 Query: 110 VPAIDH-----YVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDE---TGVTPVINQI 161 + +AW+ ++E +K G ++ IG+ N I HL++L PV+NQI Sbjct: 131 FFTTEQTHGYTLEQAWEALVEAKKAGKVREIGISNAAIPHLEKLFAASPSPEYYPVVNQI 190 Query: 162 ELHPLMQQ--RQLHAWNATHKIQTESWSPLAQGGKGVFDQ--KVIRDLADKYGKTPAQIV 217 E HP +Q + + + H I E++SPLA + + + ++ LA+KY KT AQ++ Sbjct: 191 EFHPFLQNQSKNIVRFCQEHGILVEAFSPLAPLARVETNALAETLKRLAEKYKKTEAQVL 250 Query: 218 IRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQ 262 +R+ L G++ + S SR+ E+ +++DF L +E+ EI K+ Sbjct: 251 LRYTLQRGILPVTTSSKESRLKESLNLFDFELTDEEVNEINKIGD 295 >1PYF-A nrPDB Length = 312 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 123/287 (42%), Gaps = 48/287 (16%) Query: 19 GLGVWQASNEEV-ITAIQKALEVGYRSIDTAAAYK---NEEGVGKALKNASVNREELFIT 74 G ++ NEE +++A+ G +DTA Y +EE +G+ L+ NRE++ I Sbjct: 25 GHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLREF--NREDVVIA 82 Query: 75 TK----------LWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMI 124 TK ++++ ++++ +SLK+L DYIDL+ +H+P EA + Sbjct: 83 TKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKD-EAVNALN 141 Query: 125 ELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTE 184 E++K G I+SIGV NF + L+ + V + + L ++ + H I Sbjct: 142 EMKKAGKIRSIGVSNFSLEQLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFI 201 Query: 185 SWSPLAQG-------GKGVFDQKVIR----------------------DLADKYGKTPAQ 215 + PL G F + +R +A+K+ Sbjct: 202 PYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPH 261 Query: 216 IVIRWHLDSGL--VVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKL 260 IV+ W+L ++IP + ++ +N D L ++++ I KL Sbjct: 262 IVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQEDISFIDKL 308 >4R9O-A nrPDB Length = 301 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 64/257 (24%), Positives = 103/257 (40%), Gaps = 40/257 (15%) Query: 23 WQASNEEVITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKL-- 77 W S ++++ I++ L++G ++D A Y + E G+AL A RE+L I TK Sbjct: 30 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHLREKLQIVTKCGI 89 Query: 78 ------------WNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIE 125 + D + + SLK L DY+D+ L+H P P +D + + Sbjct: 90 ATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDAD-DVAEAFQH 148 Query: 126 LQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW---NATHKIQ 182 L + G ++ GV NF L T NQ+E+ P+ Q L +I+ Sbjct: 149 LHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIR 208 Query: 183 TESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENF 242 +WS L GG +F+ + + L + L VI + + S I + Sbjct: 209 PMAWSCL--GGGRLFNDEAYQPLRQE-----------------LSVIAQELNASSIEQVV 249 Query: 243 DVWDFRLDKDELGEIAK 259 W RL L I Sbjct: 250 YAWILRLPSQPLPIIGS 266 >1OG6-A nrPDB Length = 298 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 101/257 (39%), Gaps = 40/257 (15%) Query: 23 WQASNEEVITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKL-- 77 W S ++++ I++ L++G ++D A Y + E G+ALK A RE + I +K Sbjct: 27 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSKCGI 86 Query: 78 ------------WNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIE 125 + D ++ SL L D++DL L+H P P +D E Sbjct: 87 ATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDAD-EVADAFKH 145 Query: 126 LQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAW---NATHKIQ 182 L + G ++ GV NF L T NQ+E+ P+ Q L +++ Sbjct: 146 LHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRVR 205 Query: 183 TESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENF 242 +WS L GG +F+ + L D+ L V+ + + I + Sbjct: 206 PMAWSCL--GGGRLFNDDYFQPLRDE-----------------LAVVAEELNAGSIEQVV 246 Query: 243 DVWDFRLDKDELGEIAK 259 + W RL L I Sbjct: 247 NAWVLRLPSQPLPIIGS 263 >3EB3-A nrPDB Length = 327 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 115/319 (36%), Gaps = 62/319 (19%) Query: 10 QDGNVMPQLGLGVW-----QASNEEVITAIQKALEVGYRSIDTAAAY---KNEEGVGKAL 61 + G + LGLG W Q ++E + A + G DTA Y K E +G + Sbjct: 10 KSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNII 69 Query: 62 KNASVNREELFITTKLWND---------DHKRPREALLDSLKKLQLDYIDLYLMHWPVPA 112 K R L ITTK++ K E L SL++LQL+Y+D+ + P P Sbjct: 70 KKKGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN 129 Query: 113 IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETG----VTPVINQIELHPLMQ 168 E + M + +G+ G + + + P+ Q E H + Sbjct: 130 TPME-ETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQR 188 Query: 169 QR-QLHAWNATHKIQT--ESWSPLAQG-------------------GKGVFDQKV----- 201 ++ ++ HKI +WSPLA G G K+ Sbjct: 189 EKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEG 248 Query: 202 ---------IRDLADKYGKTPAQIVIRWHLD-SGL-VVIPKSVTPSRIAENFDVWDF--R 248 ++ +A++ G T Q+ I W L G+ V+ + ++ EN + Sbjct: 249 RRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPK 308 Query: 249 LDKDELGEIAKLDQGKRLG 267 L + EI + K Sbjct: 309 LSSSIVHEIDSILGNKPYS 327 >1PZ1-A nrPDB Length = 333 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 79/313 (25%), Positives = 130/313 (41%), Gaps = 57/313 (18%) Query: 11 DGNVMPQLGLGVWQA--------SNEEVITAIQKALEVGYRSIDTAAAY---KNEEGVGK 59 G ++GLG W + I I+ AL+ G IDTA AY ++EE VGK Sbjct: 9 TGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGK 68 Query: 60 ALKNASVNREELFITTKL---WNDD-------HKRPREALLDSLKKLQLDYIDLYLMHWP 109 A+K + R+++ + TK W ++ R E + +SLK+LQ DYIDLY +HWP Sbjct: 69 AIKE-YMKRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWP 127 Query: 110 VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQ 169 P + E + M EL G I++IGV NF I + + + L + Sbjct: 128 DPLVP-IEETAEVMKELYDAGKIRAIGVSNFSIEQMDTFRAVAPLHTIQPPYNLFEREME 186 Query: 170 RQLHAWNATHKIQTESWSPLAQG-------GKGVFDQKVIR------------------- 203 + + +KI T + L +G + F+ +R Sbjct: 187 ESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTFEGDDLRNHDPKFQKPRFKEYLSAVN 246 Query: 204 ---DLAD-KYGKTPAQIVIRWHLDSGLVVIP--KSVTPSRIAENFDVWDFRLDKDELGEI 257 LA +YGK+ + +RW LD I + P ++ ++ + L+ ++ +I Sbjct: 247 QLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGARKPGQLEALSEITGWTLNSEDQKDI 306 Query: 258 AKLDQGKRLGPDP 270 + + DP Sbjct: 307 NTILENT--ISDP 317 >3N6Q-A nrPDB Length = 346 Score = 156 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 119/312 (38%), Gaps = 63/312 (20%) Query: 10 QDGNVMPQLGLGVWQASN-----EEVITAIQKALEVGYRSIDTAAAYK-----NEEGVGK 59 + G +P L LG+W E ++KA ++G D A Y EE G+ Sbjct: 20 KSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 60 ALK-NASVNREELFITTKLWNDDHKRPR----------EALLDSLKKLQLDYIDLYLMHW 108 L+ + + R+EL I+TK D P +L SLK++ L+Y+D++ H Sbjct: 80 LLREDFAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHR 139 Query: 109 PVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQR---LIDETGVTPVINQIELHP 165 E + + G +G+ ++ Q+ L+ E + +I+Q + Sbjct: 140 VDENTPME-ETASALAHAVQSGKALYVGISSYSPERTQKMVELLREWKIPLLIHQPSYNL 198 Query: 166 LMQ---QRQLHAWNATHKIQTESWSPLAQG--------------------------GKGV 196 L + + L + + +++PLAQG + Sbjct: 199 LNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMHREGNKVRGLTPKM 258 Query: 197 FDQK------VIRDLADKYGKTPAQIVIRWHL--DSGLVVIPKSVTPSRIAENFD-VWDF 247 + ++ ++A + G++ AQ+ + W L D V+ + ++ EN + + Sbjct: 259 LTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVTSVLIGASRAEQLEENVQALNNL 318 Query: 248 RLDKDELGEIAK 259 EL +I + Sbjct: 319 TFSTKELAQIDQ 330 >1LQA-A nrPDB Length = 346 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 76/341 (22%), Positives = 119/341 (34%), Gaps = 82/341 (24%) Query: 10 QDGNVMPQLGLGVW----QASNEEVITAIQKALEVGYRSIDTAAAYK----------NEE 55 + LGLG Q S + + A+ G ID A Y E Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTET 67 Query: 56 GVGKALKNASVNREELFITTKLWND--------------DHKRPREALLDSLKKLQLDYI 101 VG L +RE+L I +K+ D K REAL DSLK+LQ DY+ Sbjct: 68 YVGNWLAKHG-SREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYL 126 Query: 102 DLYLMHWPVPAIDHY----------------VEAWKGMIELQKEGLIKSIGVCNFQIHHL 145 DLY +HWP + + ++ + E Q+ G I+ IGV N + Sbjct: 127 DLYQVHWPQRPTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVSNETAFGV 186 Query: 146 QRLI------DETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQG------- 192 R + D + + N L + L + ++ ++S L G Sbjct: 187 MRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGFGTLTGKYL 246 Query: 193 --------GKGVFD----------QKVIRD---LADKYGKTPAQIVIRWHLDSGLV--VI 229 +F QK + +A ++G PAQ+ + + V + Sbjct: 247 NGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRRQPFVASTL 306 Query: 230 PKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDP 270 + T ++ N + L +D L EI + Q P P Sbjct: 307 LGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTY-PAP 346 >4EXA-A nrPDB Length = 292 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 36/230 (15%) Query: 11 DGNVMPQLGLGVWQ---------------ASNEEVITAIQKALEVGYRSIDTAAAYK-NE 54 G + LGLG + + E + A ++G IDTA AY +E Sbjct: 38 TGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRSE 97 Query: 55 EGVGKALKN-------ASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMH 107 E +G L+ S EE +++ R ++ SLK+L+ D I+L L+H Sbjct: 98 ERLGPLLRGQREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRLETDRIELVLVH 157 Query: 108 WPVPAID--HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLI---DETGVTPVINQIE 162 +D E + + L++EGLI + G+ + R + D VT +N+ Sbjct: 158 SDGNDLDILENSEVYPTLAALKREGLIGAYGLSGKTVEGGLRALREGDCAMVTYNLNERA 217 Query: 163 LHPLMQQRQLH--------AWNATHKIQTESWSPLAQGGKGVFDQKVIRD 204 P+++ H A + H P+ + VFDQ + Sbjct: 218 ERPVIEYAAAHAKGILVKKALASGHACLGAGQDPVRASFELVFDQPGVAA 267 >1GVE-A nrPDB Length = 327 Score = 75.3 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 79/195 (40%), Gaps = 19/195 (9%) Query: 16 PQLGLGVWQASNEE----VITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNR 68 P LG + +++ L+ G+ IDTA Y ++E +G + Sbjct: 6 PATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSG 65 Query: 69 EELFITTKLWNDDHKRPREA-----LLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGM 123 ++ I TK K + A L SLK+LQ +DL+ +H+P E + Sbjct: 66 CKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTP-IEETLQAC 124 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETG----VTPVINQIELHPLMQQRQLHAW-NAT 178 +L +EG +G+ N+ + + + P + Q + + +Q + + Sbjct: 125 HQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLR 184 Query: 179 H-KIQTESWSPLAQG 192 H ++ +++PLA G Sbjct: 185 HFGLRFYAFNPLAGG 199 >2BP1-A nrPDB Length = 360 Score = 75.3 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 96/292 (32%), Gaps = 63/292 (21%) Query: 38 LEVGYRSIDTAAAY---KNEEGVGKALKNASVNREELFITTKL--WNDD---HKRPREAL 89 LE G+ +DTA Y ++E +G + I TK W+ R L Sbjct: 65 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 124 Query: 90 LDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLI 149 SLK+LQ +DL+ +H P E L +EG +G+ N+ + + Sbjct: 125 ETSLKRLQCPQVDLFYLHAPDHGTP-VEETLHACQRLHQEGKFVELGLSNYASWEVAEIC 183 Query: 150 DETG----VTPVINQIELHPLMQQRQLHAW-NATH-KIQTESWSPLAQG---GKGVFDQK 200 + P + Q + +Q + + H ++ +++PLA G GK ++ K Sbjct: 184 TLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK 243 Query: 201 ---------------------------------VIRDLADKYGKTPAQI---VIRW---- 220 V + L YG + + +RW Sbjct: 244 DGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHH 303 Query: 221 -HLD--SGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPD 269 L G VI + ++ +N + + + +Q L Sbjct: 304 SQLQGAHGDAVILGMSSLEQLEQNLAATE-EGPLEP-AVVDAFNQAWHLVAH 353 >2CLP-A nrPDB Length = 347 Score = 74.9 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 60/318 (18%), Positives = 111/318 (34%), Gaps = 67/318 (21%) Query: 16 PQLGLGVWQAS---NEEVITAIQKA-LEVGYRSIDTAAAY---KNEEGVGKALKNASVNR 68 P LG + + A+ +A LE G+ IDTA Y ++E +G + Sbjct: 26 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSD 85 Query: 69 EELFITTK---LWNDD--HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGM 123 + I TK L+ + R L SLK+LQ +DL+ +H P + E + Sbjct: 86 CRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP-VEETLRAC 144 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETG----VTPVINQIELHPLMQQRQLHAW-NAT 178 +L +EG +G+ N+ + + + P + Q + + +Q + + Sbjct: 145 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLR 204 Query: 179 H-KIQTESWSPLAQG---GKGVFDQK---------------------------------V 201 H ++ +++PLA G GK ++ K V Sbjct: 205 HFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV 264 Query: 202 IRDLADKYGKTPAQI---VIRW-----HLD--SGLVVIPKSVTPSRIAENFDVWDFRLDK 251 + L YG + + +RW L G VI + ++ +N + Sbjct: 265 EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAE-EGPL 323 Query: 252 DELGEIAKLDQGKRLGPD 269 + + +Q L Sbjct: 324 EP-AVVDAFNQAWHLVAH 340 >2C91-A nrPDB Length = 338 Score = 71.4 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 41/195 (21%), Positives = 74/195 (37%), Gaps = 19/195 (9%) Query: 16 PQLGLGVWQASNEE----VITAIQKALEVGYRSIDTAAAY---KNEEGVGKALKNASVNR 68 P LG + +++ LE G+ +DTA Y ++E +G Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGD 76 Query: 69 EELFITTKL--W---NDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGM 123 + I TK W + R L SLK+LQ +DL+ +H P + E Sbjct: 77 CTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTP-VEETLCAC 135 Query: 124 IELQKEGLIKSIGVCNFQIHHLQRLIDETG----VTPVINQIELHPLMQQRQL-HAWNAT 178 +L +EG +G+ N+ + + + P + Q + +Q + Sbjct: 136 HQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAELLPCLR 195 Query: 179 H-KIQTESWSPLAQG 192 H ++ +++PLA G Sbjct: 196 HFGLRFYAYNPLAGG 210 >2OHJ-A nrPDB Length = 404 Score = 31.8 bits (71), Expect = 0.36, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 25/69 (36%), Gaps = 10/69 (14%) Query: 43 RSIDTAAAYKNEEGVGKALKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYID 102 R A Y E V LK+ RE F+T K + + +L L+ Sbjct: 97 RRFPEAPIYCTEVAVKGLLKHYPSLREAEFMTVKTGD-----VLDLGGKTLTFLETP--- 148 Query: 103 LYLMHWPVP 111 L+HWP Sbjct: 149 --LLHWPDS 155 >2YZ5-A nrPDB Length = 267 Score = 30.6 bits (68), Expect = 0.73, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 37/92 (40%), Gaps = 15/92 (16%) Query: 60 ALKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYI---DLYLMHWPVPAIDHY 116 AL+ ++L++ L D H L L++ DY+ YL WP+ DH Sbjct: 62 ALERVRERAQDLYVGIGLEADFHPGTEGFLAQLLRRYPFDYVIGSVHYLGAWPLDHPDHQ 121 Query: 117 VE-AWKGM-----------IELQKEGLIKSIG 136 E AW+ + + + GL +IG Sbjct: 122 EEYAWRDLKEVFRAYFQEVEKAARSGLFHAIG 153 >4L1C-A nrPDB Length = 103 Score = 30.2 bits (67), Expect = 0.95, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 24/59 (40%), Gaps = 3/59 (5%) Query: 104 YLMHWPVPAIDHYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN 159 +L H PV +E W M + ++ IGV + L+ I++ G+ + Sbjct: 44 FLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPILTE 102 >4YMI-A nrPDB Length = 233 Score = 30.2 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 24/68 (35%), Gaps = 6/68 (8%) Query: 91 DSLKKLQLDY--IDLYLMHWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRL 148 D+L L+ + DLY + + +W+ +L L K IGV Sbjct: 113 DTLTDLRTAHPDADLYFI--TGADALASILSWENWEQLFT--LAKFIGVSRPGYELSSDH 168 Query: 149 IDETGVTP 156 I + P Sbjct: 169 IAHAELPP 176 >5WSO-A nrPDB Length = 476 Score = 29.8 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 13/26 (50%) Query: 101 IDLYLMHWPVPAIDHYVEAWKGMIEL 126 +DL + WP P VE K + ++ Sbjct: 448 VDLLGLDWPDPGNQQVVETGKALKQV 473 >2B3Y-A nrPDB Length = 888 Score = 29.8 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 4/41 (9%), Positives = 14/41 (34%), Gaps = 1/41 (2%) Query: 166 LMQQRQLHAWNATHKIQTESWSPLAQ-GGKGVFDQKVIRDL 205 +Q+ + + + + + G G + V+ + Sbjct: 480 YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAI 520 >4L6H-A nrPDB Length = 789 Score = 29.8 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 39/108 (36%), Gaps = 5/108 (4%) Query: 12 GNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNREEL 71 G +P+L L + + AI+ G+ D + + V LK+ + Sbjct: 265 GADVPELILTTYFGDVRPNLKAIENLPVAGF-HFDFVRVPEQLDEVASILKDGQTLSAGV 323 Query: 72 FITTKLWNDDHKRPREALLDSLKKLQLDYIDLY----LMHWPVPAIDH 115 +W D + + +++K+ D + + L+H PV Sbjct: 324 VDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESE 371 >4EHI-A nrPDB Length = 534 Score = 29.4 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 25/57 (43%), Gaps = 15/57 (26%) Query: 42 YRSIDTAAAYKNEEGVGKALKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQL 98 ++ ID Y+N + VG+ +EL K N REA + LK L++ Sbjct: 383 FKHIDGGFVYQNSDEVGE---------DEL----K--NAKLMSQREASKEELKDLEI 424 >3QLD-A nrPDB Length = 388 Score = 29.1 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 36/100 (36%), Gaps = 14/100 (14%) Query: 30 VITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNREELFITTKLWNDDHKRPREAL 89 +I ++ A+E G+R + A + A+K + +L I L Sbjct: 153 LIQSVDAAVEQGFRRVKLKIAPGRDRA---AIKAVRLRYPDLAIAADANGSYRPEDAPVL 209 Query: 90 LDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKE 129 QLD DL + P+P D W + +LQ Sbjct: 210 R------QLDAYDLQFIEQPLPEDD-----WFDLAKLQAS 238 >6C95-A nrPDB Length = 866 Score = 28.7 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 24/59 (40%), Gaps = 8/59 (13%) Query: 47 TAAAYKNEEGVGKALKN-ASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLY 104 A AYK G+ALK + R + IT ++ R+ L S Y+DL Sbjct: 491 CAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRS-------YVDLL 542 >3Q3N-A nrPDB Length = 500 Score = 27.9 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 9/29 (31%), Positives = 12/29 (41%), Gaps = 3/29 (10%) Query: 80 DDHKRPREALLDSLKKLQLD---YIDLYL 105 ++ SL L LD Y DL+L Sbjct: 293 FMYEWIIGQFERSLIDLGLDKPWYWDLFL 321 >4X3Q-A nrPDB Length = 355 Score = 27.5 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 50/137 (36%), Gaps = 26/137 (18%) Query: 47 TAAAYKNEEGVGKALKNASVN--REELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLY 104 T Y+N +G A ++ R+ + K+ E+L + + + Sbjct: 71 TDGGYRNGAPIGAAFRDGLWPVLRDIVQYQDKIAYQPAADYVESL-RTGQNAGIR----- 124 Query: 105 LMHWPVPAIDHY--VEAWKGMIELQKEGLIKSIGVCN--------FQIHHLQRLIDETGV 154 H+P D Y + A G+ EL G+ + N F + R++D G Sbjct: 125 --HFPGTTRDLYSRLAAVPGLEELFYRGMHAWSQLSNPVLLAQPDFT--RVHRVLDVGGG 180 Query: 155 TPVINQIEL---HPLMQ 168 +N + L HP ++ Sbjct: 181 D-AVNAVALARAHPSLR 196 >6N2G-A nrPDB Length = 316 Score = 27.1 bits (59), Expect = 7.8, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 17/26 (65%) Query: 56 GVGKALKNASVNREELFITTKLWNDD 81 +G+A+++ + R LF T +L +DD Sbjct: 271 EMGQAIRDTIIPRAVLFYTGELQSDD 296 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.155 0.474 Lambda K H 0.267 0.0475 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,342,879 Number of Sequences: 36641 Number of extensions: 627178 Number of successful extensions: 2036 Number of sequences better than 10.0: 66 Number of HSP's better than 10.0 without gapping: 103 Number of HSP's successfully gapped in prelim test: 24 Number of HSP's that attempted gapping in prelim test: 1524 Number of HSP's gapped (non-prelim): 133 length of query: 275 length of database: 10,336,785 effective HSP length: 96 effective length of query: 179 effective length of database: 6,819,249 effective search space: 1220645571 effective search space used: 1220645571 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.1 bits)