BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q42525 (496 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4QS9-A nrPDB 956 0.0 5ZQT-A nrPDB 646 0.0 3O1W-A nrPDB 277 7e-75 1BDG-A nrPDB 265 3e-71 1IG8-A nrPDB 253 1e-67 1BG3-A nrPDB 251 4e-67 4FOI-A nrPDB 247 1e-65 5HFU-A nrPDB 245 3e-65 3HM8-A nrPDB 242 3e-64 3B8A-X nrPDB 237 1e-62 4DCH-A nrPDB 235 3e-62 3W0L-A nrPDB 234 6e-62 2YHX-A nrPDB 41 0.001 1HKG-A nrPDB 40 0.002 1UR1-A nrPDB 31 1.6 1JUE-A nrPDB 30 1.7 6BPQ-A nrPDB 30 2.5 2NN6-I nrPDB 30 3.3 3PFO-A nrPDB 29 3.7 5ZZ8-r nrPDB 29 5.1 3IEF-A nrPDB 28 6.7 6HSV-A nrPDB 28 7.4 2OKL-A nrPDB 28 7.7 3DCY-A nrPDB 28 8.3 >4QS9-A nrPDB Length = 474 Score = 956 bits (2472), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/468 (99%), Positives = 467/468 (99%) Query: 29 QSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL 88 SSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL Sbjct: 7 HSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL 66 Query: 89 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA 148 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA Sbjct: 67 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA 126 Query: 149 EALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 208 EALAKFVATECEDFHLPEGRQRELGFTF+FPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV Sbjct: 127 EALAKFVATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 186 Query: 209 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK 268 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK Sbjct: 187 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK 246 Query: 269 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 328 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR Sbjct: 247 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 306 Query: 329 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS 388 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS Sbjct: 307 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS 366 Query: 389 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ 448 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ Sbjct: 367 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ 426 Query: 449 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS 496 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS Sbjct: 427 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS 474 >5ZQT-A nrPDB Length = 473 Score = 646 bits (1666), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/464 (67%), Positives = 379/464 (81%), Gaps = 5/464 (1%) Query: 34 WGRV---LAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPS 90 W R+ A+++ E+ +TP + LR +ADAM EM GL +D + LKMLISYVDNLP+ Sbjct: 6 WIRIPMAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPT 65 Query: 91 GDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEA 150 GDE GLFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA Sbjct: 66 GDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAE 125 Query: 151 LAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGA 210 L FV TE EDFHLPEGRQRELGFTFSFPV QTS+SSG+LIKWTKGFSI VG+DVV Sbjct: 126 LESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAE 185 Query: 211 LNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWH 270 L++A+ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW Sbjct: 186 LSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWT 245 Query: 271 GLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRV 330 GLLP+SG MVINMEWGNF+S LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+ Sbjct: 246 GLLPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 305 Query: 331 LLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLK 390 LLK+A DA+ FGD VP+KL FI+RTP MSAMH+DTS DLK +G+K+KDIL V TSL+ Sbjct: 306 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 365 Query: 391 MRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDE--EVQKSVIAMDGGLFEHYTQ 448 R + + +C+++A RGARL+AAGIYGILKKLGRD + + Q++VIA+DGGL+EHY + Sbjct: 366 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 425 Query: 449 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 492 F C+E++L +LLG+EA+ SV V +NDGSGIGAALLAASHS Y Sbjct: 426 FRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 469 >3O1W-A nrPDB Length = 485 Score = 277 bits (709), Expect = 7e-75, Method: Compositional matrix adjust. Identities = 165/446 (36%), Positives = 245/446 (54%), Gaps = 29/446 (6%) Query: 54 KLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVL 113 K+R + E+ GL+ GG+ + M+ +V P+G E G F ALDLGGTN RV+ V Sbjct: 40 KMRSIVKHFISELDKGLSKKGGN-IPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVK 98 Query: 114 LGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL- 172 LGG + Q + +P HL TG S++L++FIA+ L +FV D P+G L Sbjct: 99 LGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV-----DEWYPDGVSEPLP 151 Query: 173 -GFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDT 231 GFTFS+P Q ++SG L +WTKGF IE G DVV L + +E++ + + + AL+NDT Sbjct: 152 LGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKLNIPINVVALINDT 211 Query: 232 VGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPK----SGEMVINMEWGN 287 GTL Y +P +I+GTG N AY + + I K GLLP+ M IN E+G+ Sbjct: 212 TGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPDSPMAINCEYGS 271 Query: 288 FRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTV 345 F + H LP T++D +D ES PG+Q EK+ SG YLGEI+R VLL + + F D Sbjct: 272 FDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQD 331 Query: 346 PSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATR 405 SKL+ +++ T + S + +D +L+ K L + TT ++ RK++ L ++ TR Sbjct: 332 ISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE-RKLIRKLAELVGTR 390 Query: 406 GARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEA 465 ARL+ G+ I K G T IA DG +F Y + E +LK++ + Sbjct: 391 AARLTVCGVSAICDKRGYKTAH--------IAADGSVFNRYPGYKEKAAQALKDIYNWDV 442 Query: 466 SG----SVEVTHSNDGSGIGAALLAA 487 +++ + DGSG+GAA++A Sbjct: 443 EKMEDHPIQLVAAEDGSGVGAAIIAC 468 >1BDG-A nrPDB Length = 451 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 162/458 (35%), Positives = 251/458 (54%), Gaps = 27/458 (5%) Query: 36 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDE 93 +V+ ILK F+ + ++ D M M GL +++ S +KM SYV P+G E Sbjct: 11 KVVEILKPFD----LSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTE 66 Query: 94 KGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAK 153 G F ALDLGGTN+RV+ V L GK + QE IP M+G ELF +IAE LA Sbjct: 67 TGNFLALDLGGTNYRVLSVTLEGKGKSPRIQE-RTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 154 FVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNK 213 F+ + + ++ +LGFTFSFP Q L+ +L++WTKGFS + G +V L Sbjct: 126 FLEN-----NGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQT 180 Query: 214 ALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL 273 L++ L+++ A+VNDTVGTLA +P +I+GTGTN AY+E ++ + G+ Sbjct: 181 ELDKRELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV- 239 Query: 274 PKSGEMVINMEWGNF-RSSHLPL--TEFDHTLDFESLNPGEQILEKIISGMYLGEILRRV 330 K E+VIN EWG F L T+FD ++D +SL+PG+Q+ EK++SGMYLGE++R + Sbjct: 240 -KEPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHI 298 Query: 331 LLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLK 390 ++ + E F +P +L++ + T +++ + D + L + D L VP Sbjct: 299 IVYLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPI 358 Query: 391 MRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFS 450 ++V C ++ R A L+ AGI IL+++ R + + +DG L++ + +F Sbjct: 359 DNRIVRYACEMVVKRAAYLAGAGIACILRRINR--------SEVTVGVDGSLYKFHPKFC 410 Query: 451 ECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS 488 E M + +L + + S DGSG GAA +AAS Sbjct: 411 ERMTDMVDKLKPKNTRFCLRL--SEDGSGKGAAAIAAS 446 >1IG8-A nrPDB Length = 486 Score = 253 bits (646), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 156/435 (35%), Positives = 227/435 (52%), Gaps = 26/435 (5%) Query: 37 VLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGL 96 ++ ++ FE+ P L+ V E+ GL+ GG+ + M+ +V + P+G E G Sbjct: 23 LMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-IPMIPGWVMDFPTGKESGD 81 Query: 97 FYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHL-MTGGSDELFNFIAEALAKFV 155 F A+DLGGTN RV+ V LGG +R + +P + T DEL+ FIA++L F+ Sbjct: 82 FLAIDLGGTNLRVVLVKLGG--DRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFI 139 Query: 156 ATECEDFHLPEGRQRE--LGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNK 213 D P+G LGFTFSFP Q ++ G L +WTKGF I DVV L K Sbjct: 140 -----DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQK 194 Query: 214 ALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL 273 + + + + + AL+NDT GTL Y +P+ VI GTG N AY + + I K G L Sbjct: 195 QITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKL 254 Query: 274 ----PKSGEMVINMEWGNFRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEIL 327 P S M IN E+G+F + H LP T++D T+D ES PG+Q EK+ SG YLGEIL Sbjct: 255 SDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEIL 314 Query: 328 RRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTT 387 R L+ M + F + SK PF++ T + + + D +L+ ++ + TT Sbjct: 315 RLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 374 Query: 388 SLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYT 447 ++ RK++ L +I R ARLS GI I +K G T IA DG ++ Y Sbjct: 375 -VQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH--------IAADGSVYNRYP 425 Query: 448 QFSECMESSLKELLG 462 F E ++LK++ G Sbjct: 426 GFKEKAANALKDIYG 440 >1BG3-A nrPDB Length = 918 Score = 251 bits (642), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 159/441 (36%), Positives = 237/441 (53%), Gaps = 26/441 (5%) Query: 55 LRQVADAMTVEMHAGLASDGGSK--LKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 112 L +V + EM GL + SK +KML S+V ++P G E G F ALDLGGTNFRV+ V Sbjct: 484 LMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLV 543 Query: 113 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL 172 + ++R V+ + SIP +M G DELF+ I ++ F+ D+ +G + L Sbjct: 544 KIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL-----DYMGIKGPRMPL 598 Query: 173 GFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVNDT 231 GFTFSFP QT+L G LI WTKGF + G DV L A++R D+ + A+VNDT Sbjct: 599 GFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDT 658 Query: 232 VGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSS 291 VGT+ Y P +I+GTGTNA Y+E + G G+M INMEWG F + Sbjct: 659 VGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDN 715 Query: 292 HL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSK 348 T+FD +D SLN G+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 716 GCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEP 775 Query: 349 LRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMRKVVISLCNIIATRG 406 L+ I T +S + +D ++ +++ IL+ ++ +V ++C +++ R Sbjct: 776 LKTRGIFETKFLSQIESD-----RLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 830 Query: 407 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEAS 466 A+L AG+ +++K+ + D + +DG L++ + FS M ++KEL Sbjct: 831 AQLCGAGMAAVVEKIRENRGLDH--LNVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPK 885 Query: 467 GSVEVTHSNDGSGIGAALLAA 487 +V S DGSG GAAL+ A Sbjct: 886 CTVSFLLSEDGSGKGAALITA 906 Score = 229 bits (583), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 157/436 (36%), Positives = 232/436 (53%), Gaps = 36/436 (8%) Query: 65 EMHAGLASDGG--SKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVV 122 EM GL+ D + +KML ++V ++P G EKG F ALDLGG++FR++RV + ++ + V Sbjct: 46 EMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV 105 Query: 123 KQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEGRQRELGFTFSFPVK 181 E E P +++ G +LF+ +A+ L F+ + +D LP +GFTFSFP + Sbjct: 106 SMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLP------VGFTFSFPCR 159 Query: 182 QTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRY 240 Q+ + LI WTK F G DVV LNKA+++ G D I A+VNDTVGT+ Y Sbjct: 160 QSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY 219 Query: 241 YNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF---RSSHLPLTE 297 + +I+GTGTNA Y+E I G G M IN EWG F S TE Sbjct: 220 DDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRTE 276 Query: 298 FDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRT 357 FD LD SLNPG+Q+ EK++SGMY+GE++R +L+KMA++ F + +L T Sbjct: 277 FDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNT 336 Query: 358 PHMSAMHND------TSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSA 411 +SA+ D L +G + D+ V V +C I++ R A L A Sbjct: 337 SDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVS---------VQHICTIVSFRSANLVA 387 Query: 412 AGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEV 471 A + IL +L RD K ++ + +DG L++ + Q+S +L+ L+ D V Sbjct: 388 ATLGAILNRL-RD-NKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRF 442 Query: 472 THSNDGSGIGAALLAA 487 S G+G GAA++ A Sbjct: 443 LLSESGTGKGAAMVTA 458 >4FOI-A nrPDB Length = 917 Score = 247 bits (630), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 157/441 (35%), Positives = 236/441 (53%), Gaps = 26/441 (5%) Query: 55 LRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 112 L +V M EM GL + + +KML S+V P G E G F ALDLGGTNFRV+ V Sbjct: 484 LLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLV 543 Query: 113 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL 172 + ++R V+ + +IP +M G +ELF+ I ++ F+ D+ +G + L Sbjct: 544 KIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL-----DYMGIKGPRMPL 598 Query: 173 GFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVNDT 231 GFTFSFP +QTSL +G LI WTKGF + VG DVV L A++R D+ + A+VNDT Sbjct: 599 GFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDT 658 Query: 232 VGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSS 291 VGT+ Y P +I+GTG+NA Y+E + G G+M INMEWG F + Sbjct: 659 VGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG---DQGQMCINMEWGAFGDN 715 Query: 292 HL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSK 348 T +D +D SLN G+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 716 GCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISET 775 Query: 349 LRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMRKVVISLCNIIATRG 406 L+ I T +S + +D ++ +++ IL+ ++ +V ++C +++ R Sbjct: 776 LKTRGIFETKFLSQIESD-----RLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRA 830 Query: 407 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEAS 466 A+L AG+ ++ K+ + D + +DG L++ + FS M ++KEL Sbjct: 831 AQLCGAGMAAVVDKIRENRGLDR--LNVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPK 885 Query: 467 GSVEVTHSNDGSGIGAALLAA 487 +V S DGSG GAAL+ A Sbjct: 886 CNVSFLLSEDGSGKGAALITA 906 Score = 229 bits (585), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 159/437 (36%), Positives = 232/437 (53%), Gaps = 38/437 (8%) Query: 65 EMHAGLASDGG--SKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVV 122 EM GL+ D + +KML ++V ++P G EKG F ALDLGG++FR++RV + ++ + V Sbjct: 46 EMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV 105 Query: 123 KQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVAT-ECEDFHLPEGRQRELGFTFSFPVK 181 E E P +++ G +LF+ +AE L F+ + +D LP +GFTFSFP + Sbjct: 106 HMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLP------VGFTFSFPCQ 159 Query: 182 QTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRY 240 Q+ + LI WTK F G DVV LNKA+++ G D I A+VNDTVGT+ Y Sbjct: 160 QSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY 219 Query: 241 YNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF---RSSHLPLTE 297 + +I+GTGTNA Y+E I G G M IN EWG F S TE Sbjct: 220 DDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRTE 276 Query: 298 FDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRT 357 FD +D SLNPG+Q+ EK++SGMYLGE++R +L+KMA++ F + +L T Sbjct: 277 FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNT 336 Query: 358 PHMSA-------MHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLS 410 +SA +HN L +G + D V V +C I++ R A L Sbjct: 337 SDVSAIEKNKEGLHN-AKEILTRLGVEPSDDDCVS---------VQHVCTIVSFRSANLV 386 Query: 411 AAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVE 470 AA + IL +L RD K ++ + ++G L++ + Q+S +L+ L+ D V Sbjct: 387 AATLGAILNRL-RD-NKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVPD---SDVR 441 Query: 471 VTHSNDGSGIGAALLAA 487 S GSG GAA++ A Sbjct: 442 FLLSESGSGKGAAMVTA 458 >5HFU-A nrPDB Length = 923 Score = 245 bits (626), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 161/442 (36%), Positives = 241/442 (54%), Gaps = 28/442 (6%) Query: 55 LRQVADAMTVEMHAGLA--SDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 112 L +++ EM GL + + +KML ++V + P G E G F ALDLGGTNFRV+ V Sbjct: 42 LLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWV 101 Query: 113 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEGRQRE 171 + + V+ E + +IP +M G +LF+ IAE LA F+ + +D LP Sbjct: 102 KVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLP------ 155 Query: 172 LGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVND 230 LGFTFSFP QT L L+ WTKGF G+DVV + KA++R G D+ I A+VND Sbjct: 156 LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVND 215 Query: 231 TVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF-- 288 TVGT+ Y + + +I+GTG+NA Y+E I G G M INMEWG F Sbjct: 216 TVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWGAFGD 272 Query: 289 -RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPS 347 S + TEFD +D SLNPG+Q+ EK+ISGMY+GE++R +L+KMA++ FG + Sbjct: 273 DGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSP 332 Query: 348 KLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVIS--LCNIIATR 405 +L T +S + + K K +++L V + +C I++TR Sbjct: 333 ELLNTGRFETKDISDIEGE-----KDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 387 Query: 406 GARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEA 465 A L AA + +L+++ + K EE +S I +DG +++ + F++ + +++ L+ Sbjct: 388 SASLCAATLAAVLQRIKEN--KGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV---P 442 Query: 466 SGSVEVTHSNDGSGIGAALLAA 487 V S DGSG GAA++ A Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTA 464 Score = 244 bits (623), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 158/441 (35%), Positives = 237/441 (53%), Gaps = 22/441 (4%) Query: 53 SKLRQVADAMTVEMHAGLASD--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVM 110 +L +V M VEM GL+ + + +KML +YV P G EKG F ALDLGGTNFRV+ Sbjct: 488 DQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVL 547 Query: 111 RVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQR 170 V + + V+ + +IP +M G DELF+ I + +A F+ ++ +G Sbjct: 548 LVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL-----EYMGMKGVSL 602 Query: 171 ELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVN 229 LGFTFSFP +Q SL L+KWTKGF G+DVV L +A+ R D+ + A+VN Sbjct: 603 PLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVN 662 Query: 230 DTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFR 289 DTVGT+ + +P +I+GTG+NA Y+E + G + G M +NMEWG F Sbjct: 663 DTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFG 719 Query: 290 SSHLP---LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVP 346 + TEFD +D SLNPG+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 720 DNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRIS 779 Query: 347 SKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRG 406 +L+ I T +S + +D L++ I L + +T +V +C ++A R Sbjct: 780 ERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGLESTC-DDSIIVKEVCTVVARRA 836 Query: 407 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEAS 466 A+L AG+ ++ ++ + D K + +DG L++ + F++ M ++K+L Sbjct: 837 AQLCGAGMAAVVDRIRENRGLD--ALKVTVGVDGTLYKLHPHFAKVMHETVKDL---APK 891 Query: 467 GSVEVTHSNDGSGIGAALLAA 487 V S DGSG GAAL+ A Sbjct: 892 CDVSFLQSEDGSGKGAALITA 912 >3HM8-A nrPDB Length = 445 Score = 242 bits (617), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 165/440 (37%), Positives = 241/440 (54%), Gaps = 29/440 (6%) Query: 54 KLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVM--R 111 +L V M M GL + S L+ML ++V P G E+G F ALDLGGTNFRV+ R Sbjct: 19 QLAAVQAQMRKAMAKGLRGEA-SSLRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVR 77 Query: 112 VLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRE 171 V G V+ E SIP + G +LF+ I + + F + G+ Sbjct: 78 VTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDF-----QQKQGLSGQSLP 126 Query: 172 LGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKAL-ERVGLDMRIAALVND 230 LGFTFSFP +Q L G L+ WTKGF + GQDVV L +A+ R +++ + A+VND Sbjct: 127 LGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVND 186 Query: 231 TVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF-- 288 TVGT+ Y +P +I+GTGTNA Y+E + G+ SG M INMEWG F Sbjct: 187 TVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVA---GVPGDSGRMCINMEWGAFGD 243 Query: 289 -RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPS 347 S + T FD ++D S+NPG+Q EK+ISGMYLGEI+R +LL + F Sbjct: 244 DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ 303 Query: 348 KLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGA 407 +L+ I +T +S + +D S L+ V + ++D L +P TS +V+ +C ++ R A Sbjct: 304 RLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTSDDA-LMVLEVCQAVSQRAA 360 Query: 408 RLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASG 467 +L AG+ +++K+ R+ EE+ SV +DG L++ + +FS + ++++EL Sbjct: 361 QLCGAGVAAVVEKI-RENRGLEELAVSV-GVDGTLYKLHPRFSSLVAATVREL---APRC 415 Query: 468 SVEVTHSNDGSGIGAALLAA 487 V S DGSG GAAL+ A Sbjct: 416 VVTFLQSEDGSGKGAALVTA 435 >3B8A-X nrPDB Length = 485 Score = 237 bits (604), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 164/444 (36%), Positives = 235/444 (52%), Gaps = 27/444 (6%) Query: 55 LRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLL 114 LR+V E++ GL GG+ + M+ +V P+G E G + A+DLGGTN RV+ V L Sbjct: 41 LRKVVKHFIDELNKGLTKKGGN-IPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKL 99 Query: 115 GGKQERVVKQEFEEVSIPPHLM--TGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL 172 G Q ++ PH M T +EL++FIA++L F+ E L L Sbjct: 100 SGNHTFDTTQSKYKL---PHDMRTTKHQEELWSFIADSLKDFM---VEQELLNTKDTLPL 153 Query: 173 GFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTV 232 GFTFS+P Q ++ G L +WTKGF I G DVV L + + L + I AL+NDTV Sbjct: 154 GFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTV 213 Query: 233 GTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL----PKSGEMVINMEWGNF 288 GTL Y +P+ VI GTG N A+ + + I K G L P + M IN E+G+F Sbjct: 214 GTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSF 273 Query: 289 RSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVP 346 + H LP T++D +D +S PG+Q EK+ SG YLGE+LR VLL++ E D Sbjct: 274 DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDL 333 Query: 347 SKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRG 406 SKL+ P+I+ T + + + +D +L+ + V TT L RK++ LC +I TR Sbjct: 334 SKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTT-LPERKLIRRLCELIGTRA 392 Query: 407 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELL---GD 463 ARL+ GI I +K G T IA DG ++ Y F E L+++ GD Sbjct: 393 ARLAVCGIAAICQKRGYKTGH--------IAADGSVYNKYPGFKEAAAKGLRDIYGWTGD 444 Query: 464 EASGSVEVTHSNDGSGIGAALLAA 487 + + + + DGSG GAA++AA Sbjct: 445 ASKDPITIVPAEDGSGAGAAVIAA 468 >4DCH-A nrPDB Length = 473 Score = 235 bits (600), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 166/475 (34%), Positives = 261/475 (54%), Gaps = 37/475 (7%) Query: 25 RRRMQSSGKWG--RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKM 80 R RM+++ K ++LA + EED L++V M EM GL + + +KM Sbjct: 5 RARMEAAKKEKVEQILAEFQLQEED-------LKKVMRRMQKEMDRGLRLETHEEASVKM 57 Query: 81 LISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQE--RVVKQEFEEVSIPPHLMTG 138 L +YV + P G E G F +LDLGGTNFRVM V +G +E VK + + SIP MTG Sbjct: 58 LPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTG 117 Query: 139 GSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFS 198 ++ LF++I+E ++ F+ D H + ++ LGFTFSFPV+ + G L+ WTKGF Sbjct: 118 TAEMLFDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFK 172 Query: 199 IEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNA 257 A G +VVG L A++R G +M + A+VNDTV T+ Y + +I+GTG NA Sbjct: 173 ASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNA 232 Query: 258 AYVERATAIPKWHGLLPKSGEMVINMEWGNF-RSSHLP--LTEFDHTLDFESLNPGEQIL 314 Y+E + G G M +N EWG F S L L E+D +D S NPG+Q+ Sbjct: 233 CYMEEMQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLY 289 Query: 315 EKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIV 374 EK+I G Y+GE++R VLL++ ++ F +LR T +S + +DT D K + Sbjct: 290 EKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQI 348 Query: 375 GSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKS 434 + + + P+T+ +V C ++TR A + +AG+ G++ ++ ++ E+V + Sbjct: 349 YNILSTLGLRPSTTDC--DIVRRACESVSTRAAHMCSAGLAGVINRM--RESRSEDVMRI 404 Query: 435 VIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVT--HSNDGSGIGAALLAA 487 + +DG +++ + F E +S++ L + S E+T S +GSG GAAL++A Sbjct: 405 TVGVDGSVYKLHPSFKERFHASVRRL-----TPSCEITFIESEEGSGRGAALVSA 454 >3W0L-A nrPDB Length = 458 Score = 234 bits (597), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 157/436 (36%), Positives = 241/436 (55%), Gaps = 28/436 (6%) Query: 62 MTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQE 119 M EM GL ++ + +KML +YV + P G E G F ALDLGGTNFRVM V +G E Sbjct: 30 MQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFLALDLGGTNFRVMLVKVGEDLE 89 Query: 120 RVVKQEFEE--VSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFS 177 K E + SIP MTG ++ LF++IAE ++ ++ D + ++ LGFTFS Sbjct: 90 GQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYL-----DQQNMKHKKLPLGFTFS 144 Query: 178 FPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLA 236 FPV+ + G L+ WTKGF A G +VVG L A++R G +M + A+VNDTV T+ Sbjct: 145 FPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMI 204 Query: 237 GGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF-RSSHLP- 294 Y + +I+GTG NA Y+E + + G + G M +N EWG F + L Sbjct: 205 SCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEG---EEGRMCVNTEWGAFGDTGELED 261 Query: 295 -LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPF 353 E+D +D SLNPG+Q+ EK+I G Y+GE++R VL+KM + FG KL+ Sbjct: 262 FRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENLLFGGESSEKLKTRG 321 Query: 354 IIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAG 413 T +S + DTS D K + ++ L V T V ++ C ++TR A + +AG Sbjct: 322 AFETQFVSQIEADTS-DFKQTLNILR-TLGVQATIGDCHAVRLA-CESVSTRAAIMCSAG 378 Query: 414 IYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVT- 472 + GIL ++ + ++ EE+ + + +DG +++ + F + +++ +L + E+T Sbjct: 379 LAGILNRMRQ--SRREELLRITVGVDGSVYKLHPSFKDKFHATVLKL-----TSGCEITF 431 Query: 473 -HSNDGSGIGAALLAA 487 S +GSG GAAL++A Sbjct: 432 IQSEEGSGRGAALISA 447 >2YHX-A nrPDB Length = 457 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 61/264 (23%), Positives = 100/264 (37%), Gaps = 23/264 (8%) Query: 78 LKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQE------RVVKQEFEEVSI 131 + M+ +V SG + G F A+ +GG + V+ + L G+QE R + +I Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 132 PPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLI 191 P L G+ N + +P LGFTF + + G + Sbjct: 104 PSDLW--GNXAXSNAAFSSXEFSSXAG----SVP------LGFTFXEAGAKEXVIKGQIT 151 Query: 192 KWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVIL 251 FS+ A ++ A+ A G A + D+ G L Y + + +I Sbjct: 152 XQAXAFSL--AXLXKLISAMXNAXFPAGDXXXSVADIXDSHGILXXVNYTDAXIKMGIIF 209 Query: 252 GTGTNAAYVERATAI--PKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNP 309 G+G NAAY +T I G +G M I + +FR + L + + +P Sbjct: 210 GSGVNAAYWCDSTXIGDAADGGXXGGAGXMXICCDQSSFRKAFPSLPQIXYLXTLNXXSP 269 Query: 310 -GEQILEKIISGMYLGEILRRVLL 332 + K G+ LR VL+ Sbjct: 270 XAXKTFXKNSXAKNXGQSLRDVLM 293 >1HKG-A nrPDB Length = 457 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 60/264 (22%), Positives = 98/264 (37%), Gaps = 23/264 (8%) Query: 78 LKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQE------RVVKQEFEEVSI 131 + M+ +V G + G F A+ +GG + V+ + L G QE R + +I Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 132 PPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLI 191 P L G+ N + +P LGFTF + + G + Sbjct: 104 PSDLW--GNXAXSNAAFSSXEFSSXAG----SVP------LGFTFXEAGAKEXVIKGQIT 151 Query: 192 KWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVIL 251 FS+ A ++ A+ A G A + D+ G L Y + + +I Sbjct: 152 XQAXAFSL--AXLXKLISAMXNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIF 209 Query: 252 GTGTNAAYVERATAI--PKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNP 309 G+G NAAY +T I G +G M + +FR + L + + +P Sbjct: 210 GSGVNAAYWCDSTXIADAADAGXXGGAGXMXVCCXQDSFRKAFPSLPQIXYXXTLNXXSP 269 Query: 310 -GEQILEKIISGMYLGEILRRVLL 332 + EK G+ LR VL+ Sbjct: 270 XAXKTFEKNSXAKNXGQSLRDVLM 293 >1UR1-A nrPDB Length = 378 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%) Query: 392 RKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDG-GLFEHYTQFS 450 R+ + + + RG + GI G LG DT E++KS+IA GL H+T Sbjct: 208 REATVEMIERLQKRGMPIHGLGIQG---HLGIDTPPIAEIEKSIIAFAKLGLRVHFTSLD 264 Query: 451 ECMESSLKELLGDEASGSVEVTHSND 476 + S+ EL E S E D Sbjct: 265 VDVLPSVWELPVAEVSTRFEYKPERD 290 >1JUE-A nrPDB Length = 311 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 56/126 (44%), Gaps = 21/126 (16%) Query: 234 TLAGGRYYNPDVVAAVI----------LGTGTNAAYVERATAIPKWHG-LLPKSGEMVIN 282 T A ++ NP + A+ + L AY+ +++ + K G LP+ ++ Sbjct: 5 TFANAKFANPFMNASGVHCMTIEDLEELKASQAGAYITKSSTLEKREGNPLPR----YVD 60 Query: 283 MEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKI----ISGMYLGEILRRVLLKMAEDA 338 +E G+ S LP FD+ LD+ N E E I+GM E + +LK +++ Sbjct: 61 LELGSINSMGLPNLGFDYYLDYVLKNQKENAQEGPIFFSIAGMSAAENI--AMLKKIQES 118 Query: 339 AFFGDT 344 F G T Sbjct: 119 DFSGIT 124 >6BPQ-A nrPDB Length = 950 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 4/53 (7%) Query: 390 KMRKVVISLCNIIATRGARLSAAGI-YGILKKLG---RDTTKDEEVQKSVIAM 438 +MRK+ L I ++GA + G YG++K +G RD T +++V+A+ Sbjct: 59 RMRKIFSRLIYIAQSKGAWIFTGGTHYGLMKYIGEVVRDNTISRSSEENVVAI 111 >2NN6-I nrPDB Length = 209 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 3/52 (5%) Query: 286 GNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAED 337 G R + TE D ++S PG+ +L K+IS LG+ LL AE+ Sbjct: 115 GTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVIS---LGDAQSNYLLTTAEN 163 >3PFO-A nrPDB Length = 433 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 7/42 (16%) Query: 203 VGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPD 244 V +DV+ A +KA LD R++ VNDT RYY+ D Sbjct: 352 VAEDVLTAAHKAAFNAPLDARLSTAVNDT-------RYYSVD 386 >5ZZ8-r nrPDB Length = 585 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 12/79 (15%) Query: 427 KDEEVQKSVIAMDGGLFEHYTQFSECMESSL-KELLGDEASGSV-----------EVTHS 474 +D+++ K+ A GG +EH + + ++L + + A G V +V H Sbjct: 295 RDDKLPKAQFAAAGGRYEHGALATHVVIATLVRHGVLPAAPGDVPRDTSTRVNPDDVAHR 354 Query: 475 NDGSGIGAALLAASHSLYL 493 +D + AA LA H+L+L Sbjct: 355 DDVNRAAAAFLARGHNLFL 373 >3IEF-A nrPDB Length = 233 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 29/55 (52%), Gaps = 8/55 (14%) Query: 116 GKQERVVK-QEFEEVSIPPHLMTGGS-------DELFNFIAEALAKFVATECEDF 162 G ER+++ +E EEVSI ++++GG D + + + ++ +CE F Sbjct: 116 GVDERIIEARELEEVSIGDYILSGGETAALVLLDAIVRLLPGVMGNEISAKCESF 170 >6HSV-A nrPDB Length = 124 Score = 28.5 bits (62), Expect = 7.4, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 26/57 (45%) Query: 201 EAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNA 257 E G + + KA+ER+ +RIA L V L P +AA+ + G +A Sbjct: 51 EVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMANGVSA 107 >2OKL-A nrPDB Length = 185 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 9/97 (9%) Query: 214 ALERVGLDMR-IAALVNDTVGTLAGGRYYNPDVVAAVI----LGTGTNAAYVERATA--I 266 A ++G+ + IA V D GTL +NP +++ + L G V+R + Sbjct: 63 AAPQIGVSKKMIAVHVTDADGTLYSHALFNPKIISHSVERTYLQGGEGCLSVDREVPGYV 122 Query: 267 PKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLD 303 P++ + K+ IN E R LP F H +D Sbjct: 123 PRYTRITVKATS--INGEEVKLRLKGLPAIVFQHEID 157 >3DCY-A nrPDB Length = 275 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 24/44 (54%) Query: 450 SECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYL 493 S C+E+SL E+ + S +V + G+ A++L SH Y+ Sbjct: 164 SNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVVSHGAYM 207 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4QS9-A nrPDB 652 0.0 5ZQT-A nrPDB 595 e-170 4FOI-A nrPDB 561 e-160 1BG3-A nrPDB 561 e-160 3O1W-A nrPDB 551 e-157 1IG8-A nrPDB 543 e-155 5HFU-A nrPDB 531 e-151 4DCH-A nrPDB 531 e-151 3B8A-X nrPDB 528 e-150 3W0L-A nrPDB 527 e-150 1BDG-A nrPDB 520 e-148 3HM8-A nrPDB 510 e-145 2YHX-A nrPDB 249 1e-66 Sequences not found previously or not previously below threshold: 1HKG-A nrPDB 239 2e-63 2YXX-A nrPDB 29 4.3 3V03-A nrPDB 29 4.8 4UST-A nrPDB 29 6.9 1Q5D-A nrPDB 28 9.6 >4QS9-A nrPDB Length = 474 Score = 652 bits (1681), Expect = 0.0, Method: Composition-based stats. Identities = 466/468 (99%), Positives = 467/468 (99%) Query: 29 QSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL 88 SSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL Sbjct: 7 HSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL 66 Query: 89 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA 148 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA Sbjct: 67 PSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIA 126 Query: 149 EALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 208 EALAKFVATECEDFHLPEGRQRELGFTF+FPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV Sbjct: 127 EALAKFVATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 186 Query: 209 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK 268 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK Sbjct: 187 GALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPK 246 Query: 269 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 328 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR Sbjct: 247 WHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 306 Query: 329 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS 388 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS Sbjct: 307 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS 366 Query: 389 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ 448 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ Sbjct: 367 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ 426 Query: 449 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS 496 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS Sbjct: 427 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS 474 >5ZQT-A nrPDB Length = 473 Score = 595 bits (1533), Expect = e-170, Method: Composition-based stats. Identities = 312/464 (67%), Positives = 379/464 (81%), Gaps = 5/464 (1%) Query: 34 WGRV---LAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPS 90 W R+ A+++ E+ +TP + LR +ADAM EM GL +D + LKMLISYVDNLP+ Sbjct: 6 WIRIPMAAAVIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPT 65 Query: 91 GDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEA 150 GDE GLFYALDLGGTNFRV+RV LGG+++RVV Q++EEV+IPPHLM G S ELF+FIA Sbjct: 66 GDEHGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAE 125 Query: 151 LAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGA 210 L FV TE EDFHLPEGRQRELGFTFSFPV QTS+SSG+LIKWTKGFSI VG+DVV Sbjct: 126 LESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAE 185 Query: 211 LNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWH 270 L++A+ER GLDM++ ALVNDTVGTLAGGRY + DV AAVILGTGTNAAYVE A AIPKW Sbjct: 186 LSRAMERQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWT 245 Query: 271 GLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRV 330 GLLP+SG MVINMEWGNF+S LP +++D+ LDFESLNPGEQI EK+ISGMYLGEI+RR+ Sbjct: 246 GLLPRSGNMVINMEWGNFKSERLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 305 Query: 331 LLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLK 390 LLK+A DA+ FGD VP+KL FI+RTP MSAMH+DTS DLK +G+K+KDIL V TSL+ Sbjct: 306 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 365 Query: 391 MRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDE--EVQKSVIAMDGGLFEHYTQ 448 R + + +C+++A RGARL+AAGIYGILKKLGRD + + Q++VIA+DGGL+EHY + Sbjct: 366 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 425 Query: 449 FSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLY 492 F C+E++L +LLG+EA+ SV V +NDGSGIGAALLAASHS Y Sbjct: 426 FRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQY 469 >4FOI-A nrPDB Length = 917 Score = 561 bits (1446), Expect = e-160, Method: Composition-based stats. Identities = 160/463 (34%), Positives = 241/463 (52%), Gaps = 29/463 (6%) Query: 36 RVLAILKAFEED---CATPISKLRQVADAMTVEMHAGLA--SDGGSKLKMLISYVDNLPS 90 R+ + EE L +V M EM GL + + +KML S+V P Sbjct: 462 RLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPD 521 Query: 91 GDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEA 150 G E G F ALDLGGTNFRV+ V + ++R V+ + +IP +M G +ELF+ I Sbjct: 522 GTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581 Query: 151 LAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGA 210 ++ F+ D+ +G + LGFTFSFP +QTSL +G LI WTKGF + VG DVV Sbjct: 582 ISDFL-----DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL 636 Query: 211 LNKALERV-GLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKW 269 L A++R D+ + A+VNDTVGT+ Y P +I+GTG+NA Y+E + Sbjct: 637 LRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMV 696 Query: 270 HGLLPKSGEMVINMEWGNFRSSHL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEI 326 G G+M INMEWG F + T +D +D SLN G+Q EK+ISGMYLGEI Sbjct: 697 EG---DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEI 753 Query: 327 LRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV-- 384 +R +L+ + F + L+ I T +S + +D ++ +++ IL+ Sbjct: 754 VRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESD-----RLALLQVRAILQQLG 808 Query: 385 PTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFE 444 ++ +V ++C +++ R A+L AG+ ++ K+ + D + +DG L++ Sbjct: 809 LNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLD--RLNVTVGVDGTLYK 866 Query: 445 HYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487 + FS M ++KEL +V S DGSG GAAL+ A Sbjct: 867 LHPHFSRIMHQTVKEL---SPKCNVSFLLSEDGSGKGAALITA 906 Score = 454 bits (1167), Expect = e-128, Method: Composition-based stats. Identities = 152/446 (34%), Positives = 229/446 (51%), Gaps = 26/446 (5%) Query: 50 TPISKLRQVADAMTVEMHAGLASD--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNF 107 L + EM GL+ D + +KML ++V ++P G EKG F ALDLGG++F Sbjct: 31 LSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSF 90 Query: 108 RVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEG 167 R++RV + ++ + V E E P +++ G +LF+ +AE L F+ + + Sbjct: 91 RILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM-----EKRKIKD 145 Query: 168 RQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGL-DMRIAA 226 ++ +GFTFSFP +Q+ + LI WTK F G DVV LNKA+++ G D I A Sbjct: 146 KKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVA 205 Query: 227 LVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWG 286 +VNDTVGT+ Y + +I+GTGTNA Y+E I G G M IN EWG Sbjct: 206 VVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWG 262 Query: 287 NFR---SSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGD 343 F S TEFD +D SLNPG+Q+ EK++SGMYLGE++R +L+KMA++ F Sbjct: 263 AFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEG 322 Query: 344 TVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKV--VISLCNI 401 + +L T +SA+ + K K+IL V +C I Sbjct: 323 RITPELLTRGKFNTSDVSAIEKN-----KEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377 Query: 402 IATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELL 461 ++ R A L AA + IL +L + ++ + ++G L++ + Q+S +L+ L+ Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKG--TPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLV 435 Query: 462 GDEASGSVEVTHSNDGSGIGAALLAA 487 D V S GSG GAA++ A Sbjct: 436 PDS---DVRFLLSESGSGKGAAMVTA 458 >1BG3-A nrPDB Length = 918 Score = 561 bits (1445), Expect = e-160, Method: Composition-based stats. Identities = 162/463 (34%), Positives = 242/463 (52%), Gaps = 29/463 (6%) Query: 36 RVLAILKAFEED---CATPISKLRQVADAMTVEMHAGLASDGGSK--LKMLISYVDNLPS 90 R+ + EE L +V + EM GL + SK +KML S+V ++P Sbjct: 462 RLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPD 521 Query: 91 GDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEA 150 G E G F ALDLGGTNFRV+ V + ++R V+ + SIP +M G DELF+ I Sbjct: 522 GTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSC 581 Query: 151 LAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGA 210 ++ F+ D+ +G + LGFTFSFP QT+L G LI WTKGF + G DV Sbjct: 582 ISDFL-----DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASL 636 Query: 211 LNKALERV-GLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKW 269 L A++R D+ + A+VNDTVGT+ Y P +I+GTGTNA Y+E + Sbjct: 637 LRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMV 696 Query: 270 HGLLPKSGEMVINMEWGNFRSSHL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEI 326 G G+M INMEWG F + T+FD +D SLN G+Q EK+ISGMYLGEI Sbjct: 697 EG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEI 753 Query: 327 LRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV-- 384 +R +L+ + F + L+ I T +S + +D ++ +++ IL+ Sbjct: 754 VRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESD-----RLALLQVRAILQQLG 808 Query: 385 PTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFE 444 ++ +V ++C +++ R A+L AG+ +++K+ + D + +DG L++ Sbjct: 809 LNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDH--LNVTVGVDGTLYK 866 Query: 445 HYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487 + FS M ++KEL +V S DGSG GAAL+ A Sbjct: 867 LHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITA 906 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 152/446 (34%), Positives = 229/446 (51%), Gaps = 26/446 (5%) Query: 50 TPISKLRQVADAMTVEMHAGLASD--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNF 107 L + EM GL+ D + +KML ++V ++P G EKG F ALDLGG++F Sbjct: 31 LSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSF 90 Query: 108 RVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEG 167 R++RV + ++ + V E E P +++ G +LF+ +A+ L F+ + + Sbjct: 91 RILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKI-----KD 145 Query: 168 RQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGL-DMRIAA 226 ++ +GFTFSFP +Q+ + LI WTK F G DVV LNKA+++ G D I A Sbjct: 146 KKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVA 205 Query: 227 LVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWG 286 +VNDTVGT+ Y + +I+GTGTNA Y+E I G G M IN EWG Sbjct: 206 VVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWG 262 Query: 287 NFR---SSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGD 343 F S TEFD LD SLNPG+Q+ EK++SGMY+GE++R +L+KMA++ F Sbjct: 263 AFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEG 322 Query: 344 TVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKV--VISLCNI 401 + +L T +SA+ D K K+IL V +C I Sbjct: 323 RITPELLTRGKFNTSDVSAIEKD-----KEGIQNAKEILTRLGVEPSDVDCVSVQHICTI 377 Query: 402 IATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELL 461 ++ R A L AA + IL +L + ++ + +DG L++ + Q+S +L+ L+ Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKG--TPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLV 435 Query: 462 GDEASGSVEVTHSNDGSGIGAALLAA 487 D V S G+G GAA++ A Sbjct: 436 PDS---DVRFLLSESGTGKGAAMVTA 458 >3O1W-A nrPDB Length = 485 Score = 551 bits (1420), Expect = e-157, Method: Composition-based stats. Identities = 166/463 (35%), Positives = 249/463 (53%), Gaps = 29/463 (6%) Query: 37 VLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGL 96 ++ + E K+R + E+ GL+ GG+ + M+ +V P+G E G Sbjct: 23 LMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKGGN-IPMIPGWVVEYPTGKETGD 81 Query: 97 FYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVA 156 F ALDLGGTN RV+ V LGG + Q + +P HL TG S++L++FIA+ L +FV Sbjct: 82 FLALDLGGTNLRVVLVKLGGNHDFDTTQN--KYRLPDHLRTGTSEQLWSFIAKCLKEFV- 138 Query: 157 TECEDFHLPEGRQ--RELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKA 214 D P+G LGFTFS+P Q ++SG L +WTKGF IE G DVV L + Sbjct: 139 ----DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQ 194 Query: 215 LERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLP 274 +E++ + + + AL+NDT GTL Y +P +I+GTG N AY + + I K GLLP Sbjct: 195 IEKLNIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLP 254 Query: 275 K----SGEMVINMEWGNFRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 328 + M IN E+G+F + H LP T++D +D ES PG+Q EK+ SG YLGEI+R Sbjct: 255 EDIGPDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMR 314 Query: 329 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTS 388 VLL + + F D SKL+ +++ T + S + +D +L+ K L + TT Sbjct: 315 LVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTV 374 Query: 389 LKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQ 448 ++ RK++ L ++ TR ARL+ G+ I K G T IA DG +F Y Sbjct: 375 VE-RKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAH--------IAADGSVFNRYPG 425 Query: 449 FSECMESSLKELLGDEASG----SVEVTHSNDGSGIGAALLAA 487 + E +LK++ + +++ + DGSG+GAA++A Sbjct: 426 YKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIAC 468 >1IG8-A nrPDB Length = 486 Score = 543 bits (1400), Expect = e-155, Method: Composition-based stats. Identities = 156/455 (34%), Positives = 233/455 (51%), Gaps = 30/455 (6%) Query: 35 GRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEK 94 ++ ++ FE+ P L+ V E+ GL+ GG+ + M+ +V + P+G E Sbjct: 21 KELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-IPMIPGWVMDFPTGKES 79 Query: 95 GLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHL-MTGGSDELFNFIAEALAK 153 G F A+DLGGTN RV+ V LGG +R + +P + T DEL+ FIA++L Sbjct: 80 GDFLAIDLGGTNLRVVLVKLGG--DRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKA 137 Query: 154 FVATECEDFHLPEGRQRE--LGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGAL 211 F+ D P+G LGFTFSFP Q ++ G L +WTKGF I DVV L Sbjct: 138 FI-----DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPML 192 Query: 212 NKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHG 271 K + + + + + AL+NDT GTL Y +P+ VI GTG N AY + + I K G Sbjct: 193 QKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQG 252 Query: 272 LL----PKSGEMVINMEWGNFRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGE 325 L P S M IN E+G+F + H LP T++D T+D ES PG+Q EK+ SG YLGE Sbjct: 253 KLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGE 312 Query: 326 ILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVP 385 ILR L+ M + F + SK PF++ T + + + D +L+ ++ + Sbjct: 313 ILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI- 371 Query: 386 TTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEH 445 T+++ RK++ L +I R ARLS GI I +K G T IA DG ++ Sbjct: 372 NTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH--------IAADGSVYNR 423 Query: 446 YTQFSECMESSLKELLGDEASG----SVEVTHSND 476 Y F E ++LK++ G + +++ + D Sbjct: 424 YPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAED 458 >5HFU-A nrPDB Length = 923 Score = 531 bits (1368), Expect = e-151, Method: Composition-based stats. Identities = 159/448 (35%), Positives = 239/448 (53%), Gaps = 22/448 (4%) Query: 46 EDCATPISKLRQVADAMTVEMHAGLA--SDGGSKLKMLISYVDNLPSGDEKGLFYALDLG 103 E +L +V M VEM GL+ + + +KML +YV P G EKG F ALDLG Sbjct: 481 EHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLG 540 Query: 104 GTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFH 163 GTNFRV+ V + + V+ + +IP +M G DELF+ I + +A F+ ++ Sbjct: 541 GTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL-----EYM 595 Query: 164 LPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDM 222 +G LGFTFSFP +Q SL L+KWTKGF G+DVV L +A+ R D+ Sbjct: 596 GMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDL 655 Query: 223 RIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVIN 282 + A+VNDTVGT+ + +P +I+GTG+NA Y+E + G + G M +N Sbjct: 656 DVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVN 712 Query: 283 MEWGNFRSSHLP---LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAA 339 MEWG F + TEFD +D SLNPG+Q EK+ISGMYLGEI+R +L+ + Sbjct: 713 MEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 772 Query: 340 FFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLC 399 F + +L+ I T +S + +D L V + ++ L + +T +V +C Sbjct: 773 LFRGRISERLKTRGIFETKFLSQIESDCLALL-QVRAILQH-LGLEST-CDDSIIVKEVC 829 Query: 400 NIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKE 459 ++A R A+L AG+ ++ ++ + D K + +DG L++ + F++ M ++K+ Sbjct: 830 TVVARRAAQLCGAGMAAVVDRIRENRGLD--ALKVTVGVDGTLYKLHPHFAKVMHETVKD 887 Query: 460 LLGDEASGSVEVTHSNDGSGIGAALLAA 487 L V S DGSG GAAL+ A Sbjct: 888 L---APKCDVSFLQSEDGSGKGAALITA 912 Score = 529 bits (1362), Expect = e-150, Method: Composition-based stats. Identities = 158/446 (35%), Positives = 238/446 (53%), Gaps = 26/446 (5%) Query: 50 TPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNF 107 L +++ EM GL + + +KML ++V + P G E G F ALDLGGTNF Sbjct: 37 LSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNF 96 Query: 108 RVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEG 167 RV+ V + + V+ E + +IP +M G +LF+ IAE LA F+ D + Sbjct: 97 RVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFM-----DKLQIKD 151 Query: 168 RQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAA 226 ++ LGFTFSFP QT L L+ WTKGF G+DVV + KA++R G D+ I A Sbjct: 152 KKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVA 211 Query: 227 LVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWG 286 +VNDTVGT+ Y + + +I+GTG+NA Y+E I G G M INMEWG Sbjct: 212 VVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWG 268 Query: 287 NF---RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGD 343 F S + TEFD +D SLNPG+Q+ EK+ISGMY+GE++R +L+KMA++ FG Sbjct: 269 AFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGG 328 Query: 344 TVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVI--SLCNI 401 + +L T +S + + K K +++L V +C I Sbjct: 329 KLSPELLNTGRFETKDISDIEGE-----KDGIRKAREVLMRLGLDPTQEDCVATHRICQI 383 Query: 402 IATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELL 461 ++TR A L AA + +L+++ + EE +S I +DG +++ + F++ + +++ L+ Sbjct: 384 VSTRSASLCAATLAAVLQRIKENKG--EERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 441 Query: 462 GDEASGSVEVTHSNDGSGIGAALLAA 487 V S DGSG GAA++ A Sbjct: 442 ---PGCDVRFLRSEDGSGKGAAMVTA 464 >4DCH-A nrPDB Length = 473 Score = 531 bits (1367), Expect = e-151, Method: Composition-based stats. Identities = 164/473 (34%), Positives = 258/473 (54%), Gaps = 33/473 (6%) Query: 25 RRRMQSSGKWG--RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLA--SDGGSKLKM 80 R RM+++ K ++LA + EED L++V M EM GL + + +KM Sbjct: 5 RARMEAAKKEKVEQILAEFQLQEED-------LKKVMRRMQKEMDRGLRLETHEEASVKM 57 Query: 81 LISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQE--RVVKQEFEEVSIPPHLMTG 138 L +YV + P G E G F +LDLGGTNFRVM V +G +E VK + + SIP MTG Sbjct: 58 LPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTG 117 Query: 139 GSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFS 198 ++ LF++I+E ++ F+ D H + ++ LGFTFSFPV+ + G L+ WTKGF Sbjct: 118 TAEMLFDYISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFK 172 Query: 199 IEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNA 257 A G +VVG L A++R G +M + A+VNDTV T+ Y + +I+GTG NA Sbjct: 173 ASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNA 232 Query: 258 AYVERATAIPKWHGLLPKSGEMVINMEWGNF-RSSHLP--LTEFDHTLDFESLNPGEQIL 314 Y+E + G G M +N EWG F S L L E+D +D S NPG+Q+ Sbjct: 233 CYMEEMQNVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLY 289 Query: 315 EKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIV 374 EK+I G Y+GE++R VLL++ ++ F +LR T +S + +DT D K + Sbjct: 290 EKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQI 348 Query: 375 GSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKS 434 + + + P+T+ +V C ++TR A + +AG+ G++ ++ ++ E+V + Sbjct: 349 YNILSTLGLRPSTTDCD--IVRRACESVSTRAAHMCSAGLAGVINRMRE--SRSEDVMRI 404 Query: 435 VIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487 + +DG +++ + F E +S++ L S + S +GSG GAAL++A Sbjct: 405 TVGVDGSVYKLHPSFKERFHASVRRL---TPSCEITFIESEEGSGRGAALVSA 454 >3B8A-X nrPDB Length = 485 Score = 528 bits (1361), Expect = e-150, Method: Composition-based stats. Identities = 162/463 (34%), Positives = 238/463 (51%), Gaps = 25/463 (5%) Query: 35 GRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEK 94 ++ + E+ LR+V E++ GL GG+ + M+ +V P+G E Sbjct: 21 KELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGN-IPMIPGWVMEFPTGKES 79 Query: 95 GLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHL-MTGGSDELFNFIAEALAK 153 G + A+DLGGTN RV+ V L G Q + +P + T +EL++FIA++L Sbjct: 80 GNYLAIDLGGTNLRVVLVKLSGNHTFDTTQ--SKYKLPHDMRTTKHQEELWSFIADSLKD 137 Query: 154 FVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNK 213 F+ E L LGFTFS+P Q ++ G L +WTKGF I G DVV L Sbjct: 138 FM---VEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQN 194 Query: 214 ALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL 273 + + L + I AL+NDTVGTL Y +P+ VI GTG N A+ + + I K G L Sbjct: 195 EISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKL 254 Query: 274 ----PKSGEMVINMEWGNFRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEIL 327 P + M IN E+G+F + H LP T++D +D +S PG+Q EK+ SG YLGE+L Sbjct: 255 ADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELL 314 Query: 328 RRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTT 387 R VLL++ E D SKL+ P+I+ T + + + +D +L+ + V TT Sbjct: 315 RLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTT 374 Query: 388 SLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYT 447 L RK++ LC +I TR ARL+ GI I +K G T IA DG ++ Y Sbjct: 375 -LPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGH--------IAADGSVYNKYP 425 Query: 448 QFSECMESSLKELLGD---EASGSVEVTHSNDGSGIGAALLAA 487 F E L+++ G + + + + DGSG GAA++AA Sbjct: 426 GFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAA 468 >3W0L-A nrPDB Length = 458 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 158/460 (34%), Positives = 245/460 (53%), Gaps = 31/460 (6%) Query: 36 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDE 93 ++L+ EED L + M EM GL ++ + +KML +YV + P G E Sbjct: 11 QILSEFHLQEED-------LHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSE 63 Query: 94 KGLFYALDLGGTNFRVMRVLLGGKQE--RVVKQEFEEVSIPPHLMTGGSDELFNFIAEAL 151 G F ALDLGGTNFRVM V +G E V+ + + SIP MTG ++ LF++IAE + Sbjct: 64 VGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECI 123 Query: 152 AKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGAL 211 + ++ D + ++ LGFTFSFPV+ + G L+ WTKGF A G +VVG L Sbjct: 124 SDYL-----DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 178 Query: 212 NKALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWH 270 A++R G +M + A+VNDTV T+ Y + +I+GTG NA Y+E + + Sbjct: 179 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVE 238 Query: 271 GLLPKSGEMVINMEWGNFRS---SHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEIL 327 G + G M +N EWG F E+D +D SLNPG+Q+ EK+I G Y+GE++ Sbjct: 239 G---EEGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELV 295 Query: 328 RRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTT 387 R VL+KM + FG KL+ T +S + DTS D K + ++ L V T Sbjct: 296 RLVLIKMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILRT-LGVQAT 353 Query: 388 SLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYT 447 V C ++TR A + +AG+ GIL ++ + ++ EE+ + + +DG +++ + Sbjct: 354 IGDCHA-VRLACESVSTRAAIMCSAGLAGILNRMRQ--SRREELLRITVGVDGSVYKLHP 410 Query: 448 QFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487 F + +++ +L + + S +GSG GAAL++A Sbjct: 411 SFKDKFHATVLKL---TSGCEITFIQSEEGSGRGAALISA 447 >1BDG-A nrPDB Length = 451 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 162/458 (35%), Positives = 251/458 (54%), Gaps = 27/458 (5%) Query: 36 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDE 93 +V+ ILK F+ + ++ D M M GL +++ S +KM SYV P+G E Sbjct: 11 KVVEILKPFD----LSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTE 66 Query: 94 KGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAK 153 G F ALDLGGTN+RV+ V L GK + QE IP M+G ELF +IAE LA Sbjct: 67 TGNFLALDLGGTNYRVLSVTLEGKGKSPRIQE-RTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 154 FVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNK 213 F+ + + ++ +LGFTFSFP Q L+ +L++WTKGFS + G +V L Sbjct: 126 FLEN-----NGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQT 180 Query: 214 ALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL 273 L++ L+++ A+VNDTVGTLA +P +I+GTGTN AY+E ++ + G+ Sbjct: 181 ELDKRELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGV- 239 Query: 274 PKSGEMVINMEWGNFR-SSHLP--LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRV 330 K E+VIN EWG F L T+FD ++D +SL+PG+Q+ EK++SGMYLGE++R + Sbjct: 240 -KEPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHI 298 Query: 331 LLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLK 390 ++ + E F +P +L++ + T +++ + D + L + D L VP Sbjct: 299 IVYLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPI 358 Query: 391 MRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFS 450 ++V C ++ R A L+ AGI IL+++ R + + +DG L++ + +F Sbjct: 359 DNRIVRYACEMVVKRAAYLAGAGIACILRRINR--------SEVTVGVDGSLYKFHPKFC 410 Query: 451 ECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS 488 E M + +L + + S DGSG GAA +AAS Sbjct: 411 ERMTDMVDKLKPKNTRFCLRL--SEDGSGKGAAAIAAS 446 >3HM8-A nrPDB Length = 445 Score = 510 bits (1312), Expect = e-145, Method: Composition-based stats. Identities = 159/452 (35%), Positives = 239/452 (52%), Gaps = 25/452 (5%) Query: 40 ILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYA 99 +L+ +L V M M GL + S L+ML ++V P G E+G F A Sbjct: 5 LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEA-SSLRMLPTFVRATPDGSERGDFLA 63 Query: 100 LDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATEC 159 LDLGGTNFRV+ V + V+ E SIP + G +LF+ I + + F Sbjct: 64 LDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDF----- 114 Query: 160 EDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV- 218 + G+ LGFTFSFP +Q L G L+ WTKGF + GQDVV L +A+ R Sbjct: 115 QQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQ 174 Query: 219 GLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGE 278 +++ + A+VNDTVGT+ Y +P +I+GTGTNA Y+E + G+ SG Sbjct: 175 AVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVA---GVPGDSGR 231 Query: 279 MVINMEWGNFRSSH---LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMA 335 M INMEWG F + T FD ++D S+NPG+Q EK+ISGMYLGEI+R +LL + Sbjct: 232 MCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLT 291 Query: 336 EDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVV 395 F +L+ I +T +S + +D S L+ V + ++D L +P TS +V Sbjct: 292 SLGVLFRGQQIQRLQTRDIFKTKFLSEIESD-SLALRQVRAILED-LGLPLTSDDA-LMV 348 Query: 396 ISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMES 455 + +C ++ R A+L AG+ +++K+ + +E + +DG L++ + +FS + + Sbjct: 349 LEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEE--LAVSVGVDGTLYKLHPRFSSLVAA 406 Query: 456 SLKELLGDEASGSVEVTHSNDGSGIGAALLAA 487 +++EL V S DGSG GAAL+ A Sbjct: 407 TVREL---APRCVVTFLQSEDGSGKGAALVTA 435 >2YHX-A nrPDB Length = 457 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 91/462 (19%), Positives = 156/462 (33%), Gaps = 40/462 (8%) Query: 39 AILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFY 98 ++++ P L+ V +T + + M+ +V SG + G F Sbjct: 7 SLVEVHXXVFIVPPXILQAVVSILTT--RXDDXDSSAASIPMVPGWVLKQVSGAQAGSFL 64 Query: 99 ALDLGGTNFRVMRVLLGGKQE------RVVKQEFEEVSIPPHLMTGGSDELFNFIAEALA 152 A+ +GG + V+ + L G+QE R + +IP L G+ N Sbjct: 65 AIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAIPSDLW--GNXAXSN------- 115 Query: 153 KFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALN 212 A LGFTF + + G + FS+ A ++ A+ Sbjct: 116 ---AAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL--AXLXKLISAMX 170 Query: 213 KALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAI--PKWH 270 A G A + D+ G L Y + + +I G+G NAAY +T I Sbjct: 171 NAXFPAGDXXXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIGDAADG 230 Query: 271 GLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNP-GEQILEKIISGMYLGEILRR 329 G +G M I + +FR + L + + +P + K G+ LR Sbjct: 231 GXXGGAGXMXICCDQSSFRKAFPSLPQIXYLXTLNXXSPXAXKTFXKNSXAKNXGQSLRD 290 Query: 330 VLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSL 389 VL+ + T + + + DL+ + + Sbjct: 291 VLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTX 349 Query: 390 KMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQF 449 M+ VV +IA RL I I +K G + IA G Y+ F Sbjct: 350 -MKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH--------IAAXGSX-RSYSGF 399 Query: 450 SECMESSLKELLGD----EASGSVEVTHSNDGSGIGAALLAA 487 S + + G S + +T + DG G + ++ + Sbjct: 400 SXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXS 441 >1HKG-A nrPDB Length = 457 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 88/462 (19%), Positives = 151/462 (32%), Gaps = 40/462 (8%) Query: 39 AILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFY 98 ++++ P L+ V + + M+ +V G + G F Sbjct: 7 SLVEVHXXVFIVPPXILQAVVS--IATTRXDDXDSAAASIPMVPGWVLKQVXGSQAGSFL 64 Query: 99 ALDLGGTNFRVMRVLLGGKQE------RVVKQEFEEVSIPPHLMTGGSDELFNFIAEALA 152 A+ +GG + V+ + L G QE R + +IP L G+ N Sbjct: 65 AIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAIPSDLW--GNXAXSN------- 115 Query: 153 KFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALN 212 A LGFTF + + G + FS+ A ++ A+ Sbjct: 116 ---AAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL--AXLXKLISAMX 170 Query: 213 KALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAI--PKWH 270 A G A + D+ G L Y + + +I G+G NAAY +T I Sbjct: 171 NAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIADAADA 230 Query: 271 GLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNP-GEQILEKIISGMYLGEILRR 329 G +G M + +FR + L + + +P + EK G+ LR Sbjct: 231 GXXGGAGXMXVCCXQDSFRKAFPSLPQIXYXXTLNXXSPXAXKTFEKNSXAKNXGQSLRD 290 Query: 330 VLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSL 389 VL+ + + + + + DL+ + + Sbjct: 291 VLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTX 349 Query: 390 KMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQF 449 M+ VV +IA RL I I +K G + IA G Y+ F Sbjct: 350 -MKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH--------IAAXGSX-RDYSGF 399 Query: 450 SECMESSLKELLGD----EASGSVEVTHSNDGSGIGAALLAA 487 S + + G S + +T + DG G ++ + Sbjct: 400 SXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXS 441 >2YXX-A nrPDB Length = 386 Score = 29.3 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 22/61 (36%), Gaps = 3/61 (4%) Query: 48 CATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNL---PSGDEKGLFYALDLGG 104 P+ L + GL GS++ + +V+ E+ F +++GG Sbjct: 154 FGIPLEDLDSFMERFRSMNIRGLHVHIGSQITRVEPFVEAFSKVVRASERYGFEEINIGG 213 Query: 105 T 105 Sbjct: 214 G 214 >3V03-A nrPDB Length = 583 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 18/60 (30%), Positives = 22/60 (36%), Gaps = 7/60 (11%) Query: 277 GEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQIL-------EKIISGMYLGEILRR 329 G+M E + L+ D + D L P L EK G YL EI RR Sbjct: 85 GDMADCCEKQEPERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARR 144 >4UST-A nrPDB Length = 475 Score = 28.5 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 27/69 (39%), Gaps = 7/69 (10%) Query: 285 WGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLG-------EILRRVLLKMAED 337 +G+F + FD L F ++ + EK S MY+ EIL + + E Sbjct: 26 YGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEK 85 Query: 338 AAFFGDTVP 346 FG + Sbjct: 86 VLIFGGDIL 94 >1Q5D-A nrPDB Length = 419 Score = 28.1 bits (61), Expect = 9.6, Method: Composition-based stats. Identities = 30/178 (16%), Positives = 59/178 (33%), Gaps = 16/178 (8%) Query: 194 TKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGT 253 TK G ++ + R L+ + ++ + + I+ Sbjct: 195 TKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAA 254 Query: 254 GTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQI 313 GT+ A + L ++ E G R++ + FD+ L ++ Q Sbjct: 255 GTDTTIY--LIAFAVLNLLRSPEALELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQD 312 Query: 314 LEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDL 371 LE + + GE++ ++ PS LR + P + + DTS L Sbjct: 313 LEYCGASIKKGEMVFLLI--------------PSALRDGTVFSRPDVFDVRRDTSASL 356 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.317 0.132 0.344 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,587,519 Number of Sequences: 36641 Number of extensions: 677043 Number of successful extensions: 2101 Number of sequences better than 10.0: 24 Number of HSP's better than 10.0 without gapping: 31 Number of HSP's successfully gapped in prelim test: 24 Number of HSP's that attempted gapping in prelim test: 1854 Number of HSP's gapped (non-prelim): 63 length of query: 496 length of database: 10,336,785 effective HSP length: 101 effective length of query: 395 effective length of database: 6,636,044 effective search space: 2621237380 effective search space used: 2621237380 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 61 (28.1 bits)