BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q42521 (502 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3HBX-A nrPDB 1044 0.0 2DGM-A nrPDB 401 e-112 5GP4-C nrPDB 386 e-107 3MC6-C nrPDB 102 3e-22 5K1R-A nrPDB 94 1e-19 3MAF-B nrPDB 91 1e-18 4Q6R-A nrPDB 80 1e-15 4W8I-A nrPDB 79 7e-15 3F9T-A nrPDB 74 2e-13 6EEQ-A nrPDB 39 0.004 1ECX-A nrPDB 33 0.25 1NJ8-A nrPDB 30 3.6 1QSO-A nrPDB 28 9.3 >3HBX-A nrPDB Length = 502 Score = 1044 bits (2699), Expect = 0.0, Method: Compositional matrix adjust. Identities = 502/502 (100%), Positives = 502/502 (100%) Query: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL Sbjct: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 Query: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG Sbjct: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE Sbjct: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 Query: 181 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP 240 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP Sbjct: 181 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP 240 Query: 241 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL 300 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL Sbjct: 241 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL 300 Query: 301 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK Sbjct: 301 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 Query: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV 420 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV Sbjct: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV 420 Query: 421 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK 480 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK Sbjct: 421 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK 480 Query: 481 QRDIITGWKKFVADRKKTSGIC 502 QRDIITGWKKFVADRKKTSGIC Sbjct: 481 QRDIITGWKKFVADRKKTSGIC 502 >2DGM-A nrPDB Length = 466 Score = 401 bits (1030), Expect = e-112, Method: Compositional matrix adjust. Identities = 197/440 (44%), Positives = 281/440 (63%), Gaps = 6/440 (1%) Query: 14 VHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECD 73 + S F ++ + T + P + + + A+QIINDEL LDGN R NLA+F TW + Sbjct: 14 LDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDENVH 73 Query: 74 KLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLA 133 KL+ SINKN++D +EYP + + RCVNM+A L++AP + AVG T+GSSEA ML Sbjct: 74 KLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACMLG 133 Query: 134 GLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQ 193 G+A K +W+ + +A GKP DKPN+V G VQ+CW KFARY++VEL+E+ + G MDP+ Sbjct: 134 GMAMKWRWRKRMEAAGKPTDKPNLVCGP-VQICWHKFARYWDVELREIPMRPGQLFMDPK 192 Query: 194 QAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAP 253 + ++ DENTI V G T G +E + L+D L + +TG D +H+DAASGGF+AP Sbjct: 193 RMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAP 252 Query: 254 FLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPT 313 F+ P++ WDFRLP VKSI+ SGHK+GL G GWVIWR++E LP+EL+F+++YLG T Sbjct: 253 FVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQIGT 312 Query: 314 FTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSK---D 370 F +NFS+ + QVIAQYY+ +RLG EGY V + L + + K + + D Sbjct: 313 FAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGRPD 372 Query: 371 EGVPLVAFSLKDSS--CHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRT 428 EG+P V F LKD +T +++S+ LR GW VPA+T+ A I V+R++ R F Sbjct: 373 EGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFEMD 432 Query: 429 LAERLVIDIEKVMRELDELP 448 AE L+ D + ++ L + P Sbjct: 433 FAELLLEDYKASLKYLSDHP 452 >5GP4-C nrPDB Length = 468 Score = 386 bits (992), Expect = e-107, Method: Compositional matrix adjust. Identities = 185/450 (41%), Positives = 285/450 (63%), Gaps = 6/450 (1%) Query: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 M+ E+D ++ F + R LP++K+ ++++ A +++ D+L+ +GN RLNL Sbjct: 3 MLYGKHTHETDETLKPIFGASAERHDLPKYKLAKHALEPREADRLVRDQLLDEGNSRLNL 62 Query: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 A+F T+MEPE +L+ ++ KN +D EYP T E++NRCVN+IA+L++AP EAE+ G Sbjct: 63 ATFCQTYMEPEAVELMKDTLEKNAIDKSEYPRTAEIENRCVNIIANLWHAP--EAESFTG 120 Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPV--DKPNIVTGANVQVCWEKFARYFEVEL 178 T+GSSEA MLAGLA K W+ + KA G + +PNIV A QVCWEKF Y+++++ Sbjct: 121 TSTIGSSEACMLAGLAMKFAWRKRAKANGLDLTAHQPNIVISAGYQVCWEKFCVYWDIDM 180 Query: 179 KEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWD 238 V + + + ++ +D VD+ TI + I+G T G+++D+ L+ ++ N+ T + Sbjct: 181 HVVPMDDDHMSLNVDHVLDYVDDYTIGIVGIMGITYTGQYDDLARLDAVVERYNRTTKFP 240 Query: 239 TPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPE 298 IHVDAASGGF PF+ PEL+WDFRL V SIN SGHKYGLVY G+GWVIWR+++ LP+ Sbjct: 241 VYIHVDAASGGFYTPFIEPELKWDFRLNNVISINASGHKYGLVYPGVGWVIWRDQQYLPK 300 Query: 299 ELIFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGL 358 EL+F ++YLG + PT +NFS +SQ+I QYY IR G +GYR + E + L + L Sbjct: 301 ELVFKVSYLGGELPTMAINFSHSASQLIGQYYNFIRFGFDGYREIQEKTHDVARYLAKSL 360 Query: 359 EKTERFNIVSKDEGVPLVAFSLKDSSCH--TEFEISDMLRRYGWIVPAYTMPPNAQHITV 416 K F++++ +PL+ + L S T +++SD L GW VP Y +P N + Sbjct: 361 TKLGGFSLINDGHELPLICYELTADSDREWTLYDLSDRLLMKGWQVPTYPLPKNMTDRVI 420 Query: 417 LRVVIREDFSRTLAERLVIDIEKVMRELDE 446 R+V+R DF ++A + D+ + + +LD+ Sbjct: 421 QRIVVRADFGMSMAHDFIDDLTQAIHDLDQ 450 >3MC6-C nrPDB Length = 497 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 101/393 (25%), Positives = 185/393 (47%), Gaps = 53/393 (13%) Query: 83 NYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQ 142 N + D +P ++++ V+M+ +FNAP ++T G T G +E+++LA L+ K Sbjct: 95 NQLHPDVFPAVRKMESEVVSMVLRMFNAP---SDTGCGTTTSGGTESLLLACLSAKMYAL 151 Query: 143 NKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDEN 202 + R + +P I+ ++K A YF ++L+ V+L Y +D + +++N Sbjct: 152 HHRG-----ITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVKKFINKN 206 Query: 203 TICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL----YPE 258 T+ + + +G +D++ L + + + P+HVD+ G FI F+ Y Sbjct: 207 TVLLVGSAPNFPHGIADDIEGLGKIAQK------YKLPLHVDSCLGSFIVSFMEKAGYKN 260 Query: 259 LE-WDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLN 317 L DFR+P V SI+ HKYG G +++RN + + + + G + TL Sbjct: 261 LPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLA 320 Query: 318 FSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKD-EGVP-- 374 S+ + V+ + ++ +G GY +E+C+E ++ +K + NI D G P Sbjct: 321 GSRPGAIVVGCWATMVNMGENGY---IESCQE-IVGAAMKFKKYIQENIPDLDIMGNPRY 376 Query: 375 -LVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAERL 433 +++FS K + H E+SD L + GW A P V + F+R L+ + Sbjct: 377 SVISFSSKTLNIH---ELSDRLSKKGWHFNALQKP----------VALHMAFTR-LSAHV 422 Query: 434 VIDIEKVMRELDELPSRVIHKISLGQEKSESNS 466 V +I ++R ++ + KSESNS Sbjct: 423 VDEICDILR------------TTVQELKSESNS 443 >5K1R-A nrPDB Length = 480 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/346 (23%), Positives = 148/346 (42%), Gaps = 32/346 (9%) Query: 83 NYVDMDEYPVTTELQNRCVNMIAHLFNAPL----EEAETAVGVGTVGSSEAIMLAGLAFK 138 N + D P +++ V M L + + A A G ++G +E+I+ A LA++ Sbjct: 79 NALQRDLCPSMNRMESEIVAMTVALLHGEAVQRHDGAHRACGALSLGGTESILNATLAYR 138 Query: 139 RKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDM 198 K + +R +++P ++ A+ + K A F ++ + +D D Sbjct: 139 EKARAERG-----IERPRMIWPASAHPAFRKAAHLFGFDVTVAPIDPVTMQVDADFVRDA 193 Query: 199 VDENTICVAAILGSTLN---GEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL 255 VD NT+ ++GS N G + + L+ + VEK D +HVD GG++ P+ Sbjct: 194 VDANTVM---LVGSACNYPYGTIDPIGALSAIAVEK------DVWLHVDGCLGGWMLPWG 244 Query: 256 ----YPEL-EWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGAD 310 YP++ +DFRLP V SI+ HK+G G + WR+ + +++G Sbjct: 245 EALGYPDIPAFDFRLPGVTSISADTHKFGYGPKGGSVLAWRDASFRRHQYFLMTDWVGGV 304 Query: 311 QPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKD 370 + L S+ + A + L LG EGY + E ++ + ++ K Sbjct: 305 YGSPGLTGSRSGGLIAATWAALRSLGREGYLARAKAIFETAFDMQAAVRAIPELRVLGK- 363 Query: 371 EGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITV 416 P F+ S + ++D +R+ GW P+A H+ V Sbjct: 364 ---PTFCFAFT-SDAFDIYHVNDFMRQRGWRFNGLQH-PDALHMCV 404 >3MAF-B nrPDB Length = 518 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 87/380 (22%), Positives = 149/380 (39%), Gaps = 37/380 (9%) Query: 81 NKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRK 140 N + D +P T + + V M AH+ T G T G +E+++LA + R Sbjct: 129 QSNPLHPDLWPSTAKFEAEVVAMTAHMLGGD-AAGGTVCGTVTSGGTESLLLA-MKTYRD 186 Query: 141 WQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 W K + P V + ++K A+YF ++L L Y D + + Sbjct: 187 WARATKG----ITAPEAVVPVSAHAAFDKAAQYFGIKLVRTPLDADYRA-DVAAMREAIT 241 Query: 201 ENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL----Y 256 NT+ VA +G + + + L E HVDA GGFI P+ Y Sbjct: 242 PNTVVVAGSAPGYPHGVVDPIPEIAALAAEHGIGC------HVDACLGGFILPWAERLGY 295 Query: 257 PELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPT--- 313 P +DFRL V S++ HKYG G +++R +L+ + ++ AD P Sbjct: 296 PVPPFDFRLEGVTSVSADTHKYGYGAKGTSVILYRRP-----DLLHYQYFIAADWPGGLY 350 Query: 314 FTLNF--SKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDE 371 F+ F S+ + + ++ LG EGY + + L+ G+ I+ Sbjct: 351 FSPTFAGSRPGALSATAWAAMLSLGEEGYLDATRRILQAADRLKAGVRAIPSLKIL---- 406 Query: 372 GVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAE 431 G PL ++ + + +M R GW + PP LR + + Sbjct: 407 GDPLWVIAVASDELNIYQVMEEMAGR-GWRLNGLHRPPAFHVALTLR-----HTEPGVVD 460 Query: 432 RLVIDIEKVMRELDELPSRV 451 R + D++ + ++ P + Sbjct: 461 RFLADLQDAVAQVRAHPEKA 480 >4Q6R-A nrPDB Length = 511 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/346 (23%), Positives = 145/346 (41%), Gaps = 27/346 (7%) Query: 83 NYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQ 142 N + D +P +++ V + LFN + G T G +E+I++A A++ Sbjct: 114 NPLHPDIFPGLRKIEAEIVRIACSLFNG----GPDSCGCVTSGGTESILMACKAYRDL-- 167 Query: 143 NKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDEN 202 A K + P IV + + K A YF +++ V L++ V D + + N Sbjct: 168 ----AFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEV-DVRAMRRAISRN 222 Query: 203 TICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL----YP- 257 T + +G + V + L V+ + P+HVDA GGF+ F+ YP Sbjct: 223 TAMLVCSTPQFPHGVIDPVPEVAKLAVK------YKIPLHVDACLGGFLIVFMEKAGYPL 276 Query: 258 ELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLN 317 E +DFR+ V SI+ HKYG G V++ +K+ + ++ G + T+ Sbjct: 277 EHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIA 336 Query: 318 FSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVA 377 S+ A + L+ G GY + + L+ LE + + + + ++A Sbjct: 337 GSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQ-LSVIA 395 Query: 378 FSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQH-ITVLRVVIR 422 +D + +S+++ GW + PP+ IT+L R Sbjct: 396 LGSRDFDI---YRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKR 438 >4W8I-A nrPDB Length = 551 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 92/368 (25%), Positives = 152/368 (41%), Gaps = 41/368 (11%) Query: 88 DEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKA 147 D++P +Q + +LF+ E G+ T G + +I+ A A+ + A Sbjct: 132 DKWPRINAMQAEVIRWCQNLFHGSKE----GYGLLTHGGTTSIIEAMAAYVIR------A 181 Query: 148 EGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVA 207 K +D P IV ++K A L V + + ++P + NT + Sbjct: 182 RAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVNPNVMSSYITRNTAVMV 241 Query: 208 AILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPELE-WDFRLP 266 S +NG + + L L +KN P HVDA GGF+ FL E DFR+P Sbjct: 242 GSAPSFMNGIHDPISELGQLAKKKN------VPFHVDACLGGFLTAFLDTSSEPMDFRVP 295 Query: 267 LVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIF-HINYLGADQPT-FTLNFSKGSSQ 324 V SI+ HKYG G ++ ED P ++ +N+ G T L+ S ++ Sbjct: 296 GVTSISADLHKYGCCPKGTSVCLF--SEDSPALSVYAALNWSGGLYATPGILDGSTSGAR 353 Query: 325 VIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK-----TERFNIVSKDE----GVPL 375 V Y L G Y+ + +++I LR ++K E N ++ ++ G P Sbjct: 354 VAEVYATLSYYGKNKYQEIA----KSIIRLRNAIQKELTALVEEGNGLTSEDIYVYGNPQ 409 Query: 376 VA-FSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQ----HITVLRVVIREDFSRTLA 430 + + ++C+ F I+D L + GW + P H+ L F + L Sbjct: 410 WSILGFRSNTCNAHF-IADELEKRGWKLNLLQNPDGFHLCLTHVHTLVGSFETQFIKDLR 468 Query: 431 ERLVIDIE 438 E VID++ Sbjct: 469 E-AVIDVK 475 >3F9T-A nrPDB Length = 397 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 88/362 (24%), Positives = 148/362 (40%), Gaps = 57/362 (15%) Query: 53 DGNPRLNLASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPL 112 DGN ++ S V P K++ + N D + T L+ + V ++ L N Sbjct: 31 DGNIFGSMCSNVL----PITRKIVDIFLETNLGDPGLFKGTKLLEEKAVALLGSLLNN-- 84 Query: 113 EEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFAR 172 + A G G +EA ++A K W+ KR+ + P I+ +EK Sbjct: 85 ---KDAYGHIVSGGTEANLMALRCIKNIWREKRRKGLSKNEHPKIIVPITAHFSFEKGRE 141 Query: 173 YFEVELKEVKLSEGYYVMDPQQAVDMVDENTI-CVAAILGSTLNGEFEDVKLLNDLLVEK 231 ++E + E Y +D + D V++ + + I G+T G ++++ L+ + E Sbjct: 142 MMDLEYIYAPIKED-YTIDEKFVKDAVEDYDVDGIIGIAGTTELGTIDNIEELSKIAKEN 200 Query: 232 NKETGWDTPIHVDAASGGFIAPFLYPE-------LEWDFRLPLVKSINVSGHKYGLVYAG 284 N IHVDAA GG + PFL + ++DF L V SI + HK G Sbjct: 201 N------IYIHVDAAFGGLVIPFLDDKYKKKGVNYKFDFSLG-VDSITIDPHKMGHCPIP 253 Query: 285 IGWVIWRNKEDLPEELIFHINYLGADQPTFT-----------LNFSKGSSQVIAQYYQLI 333 G +++++ I + YL D P T + F + + +Y Sbjct: 254 SGGILFKD--------IGYKRYLDVDAPYLTETRQATILGTRVGFGGACTYAVLRY---- 301 Query: 334 RLGHEGYRNVMENCRENMIVLREGLEKTER-------FNIVS-KDEGVPLVAFSLKDSSC 385 LG EG R ++ C EN + L + L++ NIV+ +DE V L+D Sbjct: 302 -LGREGQRKIVNECMENTLYLYKKLKENNFKPVIEPILNIVAIEDEDYKEVCKKLRDRGI 360 Query: 386 HT 387 + Sbjct: 361 YV 362 >6EEQ-A nrPDB Length = 490 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 69/311 (22%), Positives = 127/311 (40%), Gaps = 36/311 (11%) Query: 91 PVTTELQNRCVNMIAHLFNAP--LEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAE 148 P TEL+N V+ +A + N P + GV + EA++ A + K N+ + Sbjct: 125 PAATELENVVVDWMAKMLNLPSSFCFSGGGGGVLQANTCEAVLCTLAAARDKALNRVGDD 184 Query: 149 GKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKL----SEGYYVMDPQQAVDMVDENT- 203 ++K + K A+ + K +K E + + P D + + Sbjct: 185 --QINKLVLYCSDQTHFTIHKGAKLIGIRSKNIKSITTKKENEFKLCPNDLRDAIRSDLE 242 Query: 204 -----ICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPE 258 V +G+T G + +K L + E +D +HVD A GG + + PE Sbjct: 243 AGLVPFYVCGTIGTTALGVVDPIKELGKVARE------FDLWLHVDGAYGG--SACICPE 294 Query: 259 LEWDFR-LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGA-----DQP 312 + + LV SI+++ HK+ L ++ ++ L E L N+L D Sbjct: 295 FQHYLDGVDLVDSISMNAHKWLLSNLDCCFLWLQSPNALIESLAAEANFLKGGSEMVDYK 354 Query: 313 TFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENM---IVLREGLEKTERFNIVSK 369 + ++ S+ + + + +IR G N++E+ R ++ + E + +RF IV Sbjct: 355 DWQISLSRRFRAI--KMWMVIR--RYGVSNLIEHIRSDVSMAVRFEEMVAADDRFEIVFP 410 Query: 370 DEGVPLVAFSL 380 + LV F L Sbjct: 411 RK-FALVCFKL 420 >1ECX-A nrPDB Length = 384 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 12/92 (13%) Query: 198 MVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYP 257 +VDE+T V+ + + G + V+ + ++ +KNKE T +HVDA PF Sbjct: 135 LVDEDTFLVSIMAANNEVGTIQPVEDVTRIVKKKNKE----TLVHVDAVQTIGKIPFSLE 190 Query: 258 ELEWDFRLPLVKSINVSGHKY-GLVYAGIGWV 288 +LE D+ + S HK+ G GI ++ Sbjct: 191 KLEVDY-------ASFSAHKFHGPKGVGITYI 215 >1NJ8-A nrPDB Length = 459 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 7/56 (12%) Query: 331 QLIRLGHEGYRNVMENCR-------ENMIVLREGLEKTERFNIVSKDEGVPLVAFS 379 QL+ + + N+MEN + EN I + E + E NI+S+ GV LV F Sbjct: 370 QLMEVVEKTLNNIMENIKNRAWEKFENFITILEDINPDEIKNILSEKRGVILVPFK 425 >1QSO-A nrPDB Length = 149 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 28/134 (20%), Positives = 52/134 (38%), Gaps = 22/134 (16%) Query: 164 QVCWEKFARYFEV----ELKEVKLSEGYYVMDPQ------QAVDMVDENTICVAAILGST 213 Q W+ + ++EV +L + +DP AV+ E I + Sbjct: 16 QRLWKSYQDFYEVSFPDDLDDFNFGR---FLDPNIKMWAAVAVESSSEKIIGMINFFNHM 72 Query: 214 LNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINV 273 +F+D +NDL V++N +GG + F+Y E + + + Sbjct: 73 TTWDFKDKIYINDLYVDENSRV---------KGAGGKLIQFVYDEADKLGTPSVYWCTDE 123 Query: 274 SGHKYGLVYAGIGW 287 S H+ L+Y +G+ Sbjct: 124 SNHRAQLLYVKVGY 137 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3HBX-A nrPDB 726 0.0 5GP4-C nrPDB 588 e-168 2DGM-A nrPDB 582 e-166 3MAF-B nrPDB 404 e-113 4Q6R-A nrPDB 394 e-110 5K1R-A nrPDB 394 e-110 3MC6-C nrPDB 368 e-102 4W8I-A nrPDB 352 2e-97 3F9T-A nrPDB 319 2e-87 Sequences not found previously or not previously below threshold: 4RIT-B nrPDB 109 4e-24 5HSI-A nrPDB 91 8e-19 6EEQ-A nrPDB 91 9e-19 2QMA-A nrPDB 87 2e-17 2OKK-A nrPDB 87 2e-17 6JRL-A nrPDB 84 1e-16 4OBV-D nrPDB 82 8e-16 3RBF-A nrPDB 79 3e-15 5O5C-A nrPDB 77 2e-14 4E1O-A nrPDB 76 3e-14 2OKJ-A nrPDB 74 2e-13 6ENZ-A nrPDB 73 3e-13 2JIS-A nrPDB 72 5e-13 1JS3-A nrPDB 72 5e-13 6EEW-A nrPDB 70 2e-12 6EEI-A nrPDB 69 5e-12 5XT5-A nrPDB 62 5e-10 5WGB-A nrPDB 61 9e-10 1T3I-A nrPDB 61 2e-09 1ECX-A nrPDB 59 3e-09 3K40-A nrPDB 58 7e-09 6EEM-B nrPDB 58 9e-09 4ISY-A nrPDB 56 4e-08 4EB7-A nrPDB 56 4e-08 3GZD-A nrPDB 52 7e-07 3A9Z-A nrPDB 49 3e-06 5HH9-A nrPDB 49 6e-06 3ELE-A nrPDB 48 1e-05 4K2M-A nrPDB 45 6e-05 2C81-A nrPDB 43 3e-04 6C9E-A nrPDB 42 5e-04 5YHV-A nrPDB 41 0.001 3NYS-A nrPDB 40 0.002 1WYV-B nrPDB 40 0.002 1GC4-A nrPDB 40 0.003 1B9H-A nrPDB 39 0.004 3UWC-A nrPDB 39 0.005 2GMS-A nrPDB 38 0.008 5WMH-A nrPDB 38 0.010 4PIW-A nrPDB 37 0.013 4M2J-A nrPDB 34 0.16 4PFU-A nrPDB 33 0.34 3FFH-A nrPDB 32 0.60 3EUC-A nrPDB 32 0.83 2Z9W-A nrPDB 31 0.92 3ZXJ-A nrPDB 31 0.96 2EH6-A nrPDB 31 1.0 6FKK-A nrPDB 31 1.5 5XFM-A nrPDB 30 2.3 4LSW-A nrPDB 30 2.7 5V41-A nrPDB 30 2.9 5ZBI-A nrPDB 29 4.2 6CN1-A nrPDB 29 5.8 >3HBX-A nrPDB Length = 502 Score = 726 bits (1873), Expect = 0.0, Method: Composition-based stats. Identities = 502/502 (100%), Positives = 502/502 (100%) Query: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL Sbjct: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 Query: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG Sbjct: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE Sbjct: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 Query: 181 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP 240 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP Sbjct: 181 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTP 240 Query: 241 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL 300 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL Sbjct: 241 IHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL 300 Query: 301 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK Sbjct: 301 IFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 Query: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV 420 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV Sbjct: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVV 420 Query: 421 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK 480 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK Sbjct: 421 IREDFSRTLAERLVIDIEKVMRELDELPSRVIHKISLGQEKSESNSDNLMVTVKKSDIDK 480 Query: 481 QRDIITGWKKFVADRKKTSGIC 502 QRDIITGWKKFVADRKKTSGIC Sbjct: 481 QRDIITGWKKFVADRKKTSGIC 502 >5GP4-C nrPDB Length = 468 Score = 588 bits (1516), Expect = e-168, Method: Composition-based stats. Identities = 185/450 (41%), Positives = 285/450 (63%), Gaps = 6/450 (1%) Query: 1 MVLSHAVSESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNL 60 M+ E+D ++ F + R LP++K+ ++++ A +++ D+L+ +GN RLNL Sbjct: 3 MLYGKHTHETDETLKPIFGASAERHDLPKYKLAKHALEPREADRLVRDQLLDEGNSRLNL 62 Query: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVG 120 A+F T+MEPE +L+ ++ KN +D EYP T E++NRCVN+IA+L++AP EAE+ G Sbjct: 63 ATFCQTYMEPEAVELMKDTLEKNAIDKSEYPRTAEIENRCVNIIANLWHAP--EAESFTG 120 Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPV--DKPNIVTGANVQVCWEKFARYFEVEL 178 T+GSSEA MLAGLA K W+ + KA G + +PNIV A QVCWEKF Y+++++ Sbjct: 121 TSTIGSSEACMLAGLAMKFAWRKRAKANGLDLTAHQPNIVISAGYQVCWEKFCVYWDIDM 180 Query: 179 KEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWD 238 V + + + ++ +D VD+ TI + I+G T G+++D+ L+ ++ N+ T + Sbjct: 181 HVVPMDDDHMSLNVDHVLDYVDDYTIGIVGIMGITYTGQYDDLARLDAVVERYNRTTKFP 240 Query: 239 TPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPE 298 IHVDAASGGF PF+ PEL+WDFRL V SIN SGHKYGLVY G+GWVIWR+++ LP+ Sbjct: 241 VYIHVDAASGGFYTPFIEPELKWDFRLNNVISINASGHKYGLVYPGVGWVIWRDQQYLPK 300 Query: 299 ELIFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGL 358 EL+F ++YLG + PT +NFS +SQ+I QYY IR G +GYR + E + L + L Sbjct: 301 ELVFKVSYLGGELPTMAINFSHSASQLIGQYYNFIRFGFDGYREIQEKTHDVARYLAKSL 360 Query: 359 EKTERFNIVSKDEGVPLVAFSLKDSSCH--TEFEISDMLRRYGWIVPAYTMPPNAQHITV 416 K F++++ +PL+ + L S T +++SD L GW VP Y +P N + Sbjct: 361 TKLGGFSLINDGHELPLICYELTADSDREWTLYDLSDRLLMKGWQVPTYPLPKNMTDRVI 420 Query: 417 LRVVIREDFSRTLAERLVIDIEKVMRELDE 446 R+V+R DF ++A + D+ + + +LD+ Sbjct: 421 QRIVVRADFGMSMAHDFIDDLTQAIHDLDQ 450 >2DGM-A nrPDB Length = 466 Score = 582 bits (1499), Expect = e-166, Method: Composition-based stats. Identities = 197/443 (44%), Positives = 281/443 (63%), Gaps = 6/443 (1%) Query: 12 VSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPE 71 + S F ++ + T + P + + + A+QIINDEL LDGN R NLA+F TW + Sbjct: 12 ELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLDGNARQNLATFCQTWDDEN 71 Query: 72 CDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIM 131 KL+ SINKN++D +EYP + + RCVNM+A L++AP + AVG T+GSSEA M Sbjct: 72 VHKLMDLSINKNWIDKEEYPQSAAIDLRCVNMVADLWHAPAPKNGQAVGTNTIGSSEACM 131 Query: 132 LAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMD 191 L G+A K +W+ + +A GKP DKPN+V G VQ+CW KFARY++VEL+E+ + G MD Sbjct: 132 LGGMAMKWRWRKRMEAAGKPTDKPNLVCGP-VQICWHKFARYWDVELREIPMRPGQLFMD 190 Query: 192 PQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFI 251 P++ ++ DENTI V G T G +E + L+D L + +TG D +H+DAASGGF+ Sbjct: 191 PKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFL 250 Query: 252 APFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQ 311 APF+ P++ WDFRLP VKSI+ SGHK+GL G GWVIWR++E LP+EL+F+++YLG Sbjct: 251 APFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNVDYLGGQI 310 Query: 312 PTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSK-- 369 TF +NFS+ + QVIAQYY+ +RLG EGY V + L + + K + + Sbjct: 311 GTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYLADEIAKLGPYEFICTGR 370 Query: 370 -DEGVPLVAFSLKDSSC--HTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFS 426 DEG+P V F LKD +T +++S+ LR GW VPA+T+ A I V+R++ R F Sbjct: 371 PDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRGWQVPAFTLGGEATDIVVMRIMCRRGFE 430 Query: 427 RTLAERLVIDIEKVMRELDELPS 449 AE L+ D + ++ L + P Sbjct: 431 MDFAELLLEDYKASLKYLSDHPK 453 >3MAF-B nrPDB Length = 518 Score = 404 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 81/375 (21%), Positives = 144/375 (38%), Gaps = 27/375 (7%) Query: 81 NKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRK 140 N + D +P T + + V M AH+ T G T G +E+++LA ++ Sbjct: 129 QSNPLHPDLWPSTAKFEAEVVAMTAHMLGGDA-AGGTVCGTVTSGGTESLLLAMKTYRDW 187 Query: 141 WQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 + K + P V + ++K A+YF ++L L Y D + + Sbjct: 188 AR-----ATKGITAPEAVVPVSAHAAFDKAAQYFGIKLVRTPLDADYRA-DVAAMREAIT 241 Query: 201 ENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF----LY 256 NT+ VA +G + + + L E HVDA GGFI P+ Y Sbjct: 242 PNTVVVAGSAPGYPHGVVDPIPEIAALAAEHGIGC------HVDACLGGFILPWAERLGY 295 Query: 257 PELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTL 316 P +DFRL V S++ HKYG G +++R + L + ++ G + T Sbjct: 296 PVPPFDFRLEGVTSVSADTHKYGYGAKGTSVILYRRPDLLHYQYFIAADWPGGLYFSPTF 355 Query: 317 NFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLV 376 S+ + + ++ LG EGY + + L+ G+ I+ G PL Sbjct: 356 AGSRPGALSATAWAAMLSLGEEGYLDATRRILQAADRLKAGVRAIPSLKIL----GDPLW 411 Query: 377 AFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAERLVID 436 ++ + + +M GW + PP LR + +R + D Sbjct: 412 VIAVASDELNIYQVMEEMAG-RGWRLNGLHRPPAFHVALTLR-----HTEPGVVDRFLAD 465 Query: 437 IEKVMRELDELPSRV 451 ++ + ++ P + Sbjct: 466 LQDAVAQVRAHPEKA 480 >4Q6R-A nrPDB Length = 511 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 92/451 (20%), Positives = 179/451 (39%), Gaps = 34/451 (7%) Query: 27 LPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKLIMSSINKNYVD 86 LP + +++ ++ D +G + S + K N + Sbjct: 59 LPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSG-EEKLTELLVKAYGDFAWSNPLH 117 Query: 87 MDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRK 146 D +P +++ V + LFN + G T G +E+I++A A++ Sbjct: 118 PDIFPGLRKIEAEIVRIACSLFNG----GPDSCGCVTSGGTESILMACKAYRDL------ 167 Query: 147 AEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICV 206 A K + P IV + + K A YF +++ V L++ +D + + NT + Sbjct: 168 AFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTK-MMEVDVRAMRRAISRNTAML 226 Query: 207 AAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL----YP-ELEW 261 +G + V + L V+ + P+HVDA GGF+ F+ YP E + Sbjct: 227 VCSTPQFPHGVIDPVPEVAKLAVK------YKIPLHVDACLGGFLIVFMEKAGYPLEHPF 280 Query: 262 DFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLNFSKG 321 DFR+ V SI+ HKYG G V++ +K+ + ++ G + T+ S+ Sbjct: 281 DFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRP 340 Query: 322 SSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVAFSLK 381 A + L+ G GY + + L+ LE + + + + ++A + Sbjct: 341 GGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQ-LSVIALGSR 399 Query: 382 DSSCHTEFEISDMLRRYGWIVPAYTMPPNAQH-ITVLRVVIREDFSRTLAERLVIDIEKV 440 D + +S+++ GW + PP+ IT+L R +A + + DI + Sbjct: 400 DFDI---YRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKR------VAIQFLKDIRES 450 Query: 441 MRELDELPSRVIHKISLGQEKSESNSDNLMV 471 + ++ + P + +++ D MV Sbjct: 451 VTQIMKNPKAKTTGMGAIYGMAQTTVDRNMV 481 >5K1R-A nrPDB Length = 480 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 85/432 (19%), Positives = 161/432 (37%), Gaps = 34/432 (7%) Query: 25 TSLPRFKMPENSIPKEAAYQIIN-DELMLDGNPRLNLASFVTTWME-PECDKLIMSSINK 82 P MP + +E + D G + + ++ + Sbjct: 21 HEFPERGMPRERLLEELRSMAVREDRKWESGRCSGTM--YCGDHEHYAFLNEAYGLFSHV 78 Query: 83 NYVDMDEYPVTTELQNRCVNMIAHLFNAPL----EEAETAVGVGTVGSSEAIMLAGLAFK 138 N + D P +++ V M L + + A A G ++G +E+I+ A LA++ Sbjct: 79 NALQRDLCPSMNRMESEIVAMTVALLHGEAVQRHDGAHRACGALSLGGTESILNATLAYR 138 Query: 139 RKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDM 198 K + +R +++P ++ A+ + K A F ++ + +D D Sbjct: 139 EKARAER-----GIERPRMIWPASAHPAFRKAAHLFGFDVTVAPIDPVTMQVDADFVRDA 193 Query: 199 VDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL--- 255 VD NT+ + + G + + L+ + VEK D +HVD GG++ P+ Sbjct: 194 VDANTVMLVGSACNYPYGTIDPIGALSAIAVEK------DVWLHVDGCLGGWMLPWGEAL 247 Query: 256 -YPELE-WDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPT 313 YP++ +DFRLP V SI+ HK+G G + WR+ + +++G + Sbjct: 248 GYPDIPAFDFRLPGVTSISADTHKFGYGPKGGSVLAWRDASFRRHQYFLMTDWVGGVYGS 307 Query: 314 FTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGV 373 L S+ + A + L LG EGY + E ++ + ++ K Sbjct: 308 PGLTGSRSGGLIAATWAALRSLGREGYLARAKAIFETAFDMQAAVRAIPELRVLGK---- 363 Query: 374 PLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAERL 433 P F+ + ++D +R+ GW P +AER Sbjct: 364 PTFCFAFTS-DAFDIYHVNDFMRQRGWRFNGLQHPDALHMCVT-----GPQTQPGVAERF 417 Query: 434 VIDIEKVMRELD 445 D+ + + Sbjct: 418 RQDLGEAVEHAR 429 >3MC6-C nrPDB Length = 497 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 98/393 (24%), Positives = 180/393 (45%), Gaps = 53/393 (13%) Query: 83 NYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQ 142 N + D +P ++++ V+M+ +FNAP + G E+++LA L+ K Sbjct: 95 NQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGT---ESLLLACLSAKMYAL 151 Query: 143 NKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDEN 202 + R + +P I+ ++K A YF ++L+ V+L Y +D + +++N Sbjct: 152 HHR-----GITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVKKFINKN 206 Query: 203 TICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFL----YPE 258 T+ + + +G +D++ L + + + P+HVD+ G FI F+ Y Sbjct: 207 TVLLVGSAPNFPHGIADDIEGLGKIAQK------YKLPLHVDSCLGSFIVSFMEKAGYKN 260 Query: 259 LEW-DFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLN 317 L DFR+P V SI+ HKYG G +++RN + + + + G + TL Sbjct: 261 LPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLA 320 Query: 318 FSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKD-EGVP-- 374 S+ + V+ + ++ +G GY +E+C+E ++ +K + NI D G P Sbjct: 321 GSRPGAIVVGCWATMVNMGENGY---IESCQE-IVGAAMKFKKYIQENIPDLDIMGNPRY 376 Query: 375 -LVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAERL 433 +++FS K + H E+SD L + GW A P V + F+R L+ + Sbjct: 377 SVISFSSKTLNIH---ELSDRLSKKGWHFNALQKP----------VALHMAFTR-LSAHV 422 Query: 434 VIDIEKVMRELDELPSRVIHKISLGQEKSESNS 466 V +I ++R ++ + KSESNS Sbjct: 423 VDEICDILR------------TTVQELKSESNS 443 >4W8I-A nrPDB Length = 551 Score = 352 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 87/396 (21%), Positives = 156/396 (39%), Gaps = 33/396 (8%) Query: 53 DGNPRLNLASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPL 112 DG L + + ++ ++ N + D++P +Q + +LF+ Sbjct: 98 DGKDSGALYAIHPKELTELLKEVYGATALTNPLH-DKWPRINAMQAEVIRWCQNLFHGSK 156 Query: 113 EEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFAR 172 E G+ T G + +I+ A A+ + + K +D P IV ++K A Sbjct: 157 E----GYGLLTHGGTTSIIEAMAAYVIRAR------AKGIDYPEIVVPETAHAAFKKAAE 206 Query: 173 YFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKN 232 L V + + ++P + NT + S +NG + + L L +KN Sbjct: 207 LTGAILITVPVDKKTGAVNPNVMSSYITRNTAVMVGSAPSFMNGIHDPISELGQLAKKKN 266 Query: 233 KETGWDTPIHVDAASGGFIAPFLYPEL-EWDFRLPLVKSINVSGHKYGLVYAGIGWVIWR 291 P HVDA GGF+ FL DFR+P V SI+ HKYG G ++ Sbjct: 267 ------VPFHVDACLGGFLTAFLDTSSEPMDFRVPGVTSISADLHKYGCCPKGTSVCLF- 319 Query: 292 NKEDLPEELIF-HINYLGADQPTFTL-NFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRE 349 ED P ++ +N+ G T + + S ++V Y L G Y+ + ++ Sbjct: 320 -SEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGKNKYQEIAKSIIR 378 Query: 350 NMIVLREGLEKT-ERFNIVSKDE----GVPLVA-FSLKDSSCHTEFEISDMLRRYGWIVP 403 +++ L E N ++ ++ G P + + ++C+ F I+D L + GW + Sbjct: 379 LRNAIQKELTALVEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHF-IADELEKRGWKLN 437 Query: 404 AYTMPPNAQ----HITVLRVVIREDFSRTLAERLVI 435 P H+ L F + L E ++ Sbjct: 438 LLQNPDGFHLCLTHVHTLVGSFETQFIKDLREAVID 473 >3F9T-A nrPDB Length = 397 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 89/362 (24%), Positives = 147/362 (40%), Gaps = 47/362 (12%) Query: 48 DELMLDGNPRLNLASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHL 107 D DGN ++ S V P K++ + N D + T L+ + V ++ L Sbjct: 26 DLKYEDGNIFGSMCSNVL----PITRKIVDIFLETNLGDPGLFKGTKLLEEKAVALLGSL 81 Query: 108 FNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCW 167 N + A G G +EA ++A K W+ KR+ + P I+ + Sbjct: 82 LNN-----KDAYGHIVSGGTEANLMALRCIKNIWREKRRKGLSKNEHPKIIVPITAHFSF 136 Query: 168 EKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTI-CVAAILGSTLNGEFEDVKLLND 226 EK ++E + E Y +D + D V++ + + I G+T G ++++ L+ Sbjct: 137 EKGREMMDLEYIYAPIKED-YTIDEKFVKDAVEDYDVDGIIGIAGTTELGTIDNIEELSK 195 Query: 227 LLVEKNKETGWDTPIHVDAASGGFIAPFLYP-------ELEWDFRLPLVKSINVSGHKYG 279 + E N IHVDAA GG + PFL ++DF L V SI + HK G Sbjct: 196 IAKENN------IYIHVDAAFGGLVIPFLDDKYKKKGVNYKFDFSL-GVDSITIDPHKMG 248 Query: 280 LVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTF------TLNFSKGSSQVIAQYYQLI 333 G +++++ I + YL D P T+ ++ Y L Sbjct: 249 HCPIPSGGILFKD--------IGYKRYLDVDAPYLTETRQATILGTRVGFGGACTYAVLR 300 Query: 334 RLGHEGYRNVMENCRENMIVLREGLEKTER-------FNIVS-KDEGVPLVAFSLKDSSC 385 LG EG R ++ C EN + L + L++ NIV+ +DE V L+D Sbjct: 301 YLGREGQRKIVNECMENTLYLYKKLKENNFKPVIEPILNIVAIEDEDYKEVCKKLRDRGI 360 Query: 386 HT 387 + Sbjct: 361 YV 362 >4RIT-B nrPDB Length = 486 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 71/370 (19%), Positives = 136/370 (36%), Gaps = 42/370 (11%) Query: 32 MPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEP------ECDKLIMSSINKNYV 85 +PE + + Q I D M+DG+ ++ M+P L+ +++N N + Sbjct: 61 IPEAAATEATLLQAIRD--MVDGSMNPANPGYI-GHMDPMPATMAILGDLVAAAVNNNML 117 Query: 86 DMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKR 145 ++ P + L+ + IA LF E A GV T G S A + A + + Sbjct: 118 SLEMSPSFSRLETLLLRAIAGLFG----LGEQAGGVLTSGGSLANLQALAVARNVAFDSV 173 Query: 146 KAEGKPV-DKPNIVTGANVQVCWEKFARYFEV-ELKEVKLSEGYYV-MDPQQAVDMVDE- 201 + + +P I +K A + + + MDP+ +D+ Sbjct: 174 EPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTAAVIPVRATADSRMDPEDLRARIDQA 233 Query: 202 -----NTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLY 256 + CV A G+T G + + + + E HVDAA GG + Sbjct: 234 RGAGQHPFCVVATAGTTTTGNIDPLAEIGAIAREHG------LWFHVDAAYGGALV--FS 285 Query: 257 PELEWDFRLPLV---KSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGA---- 309 W RL + SI + K+ V V++R+ L Y+ A Sbjct: 286 ERHRW--RLAGIEQADSITFNPQKWLYVAKTCAMVLFRDAGVLERAFRIPAPYMRATDGF 343 Query: 310 -DQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVS 368 + + ++ + V+ + L +G +GY ++++ + EG+ + + Sbjct: 344 INLGEIGVQGTRHAD-VVKLWLTLQHIGQQGYARLIDDGYRLAERVVEGVRQRPFLRLAG 402 Query: 369 KDEGVPLVAF 378 + + +V F Sbjct: 403 EIDTN-IVCF 411 >5HSI-A nrPDB Length = 634 Score = 91.4 bits (225), Expect = 8e-19, Method: Composition-based stats. Identities = 48/254 (18%), Positives = 82/254 (32%), Gaps = 50/254 (19%) Query: 158 VTGANVQVCWEKFARYFEV---ELKEVKLSEGYYVMDPQQAVDMVDENTI------CVAA 208 + W K A + ++ V + Y MD Q ++ + V Sbjct: 235 LVPQTKHYSWMKAADIIGIGLDQVVPVPIDSNYR-MDIQALESIIRKYAAEKTPILGVVG 293 Query: 209 ILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFI-APFLYPELEW------ 261 + GST G + + + L + KE + +HVDAA GG+ A FL + ++ Sbjct: 294 VAGSTEEGAVDGIDKIVALRQKLQKEGIY-FYLHVDAAYGGYARALFLDEDDQFIPYKNL 352 Query: 262 --------------DFRLPLV----------KSINVSGHKYGLVYAGIGWVIWRNKEDLP 297 ++ P V +SI + HK G V G ++ ++ Sbjct: 353 QKVHAENHVFTEDKEYIKPEVYAAYKAFDQAESITIDPHKMGYVPYSAGGIVIQDIRMRD 412 Query: 298 EELIFHINYL--GADQPTF----TLNFSKGSSQVIAQYYQLIRLGHE--GYRNVMENCRE 349 F GAD P L SK + + + L GY + E Sbjct: 413 TISYFATYVFEKGADIPALLGAYILEGSKAGATAASVWAAHHTLPLNVTGYGKLEGASIE 472 Query: 350 NMIVLREGLEKTER 363 + L+ + Sbjct: 473 GAHRYYDFLKNLKF 486 >6EEQ-A nrPDB Length = 490 Score = 91.4 bits (225), Expect = 9e-19, Method: Composition-based stats. Identities = 71/375 (18%), Positives = 133/375 (35%), Gaps = 35/375 (9%) Query: 91 PVTTELQNRCVNMIAHLFNAPLEE--AETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAE 148 P TEL+N V+ +A + N P + GV + EA++ A + K N+ Sbjct: 125 PAATELENVVVDWMAKMLNLPSSFCFSGGGGGVLQANTCEAVLCTLAAARDKALNRVG-- 182 Query: 149 GKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKL----SEGYYVMDPQQAVDMV-DENT 203 ++K + K A+ + K +K E + + P D + + Sbjct: 183 DDQINKLVLYCSDQTHFTIHKGAKLIGIRSKNIKSITTKKENEFKLCPNDLRDAIRSDLE 242 Query: 204 ICVA-----AILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPE 258 + +G+T G + +K L + E +D +HVD A GG + Sbjct: 243 AGLVPFYVCGTIGTTALGVVDPIKELGKVARE------FDLWLHVDGAYGGSACICPEFQ 296 Query: 259 LEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGA-----DQPT 313 D + LV SI+++ HK+ L ++ ++ L E L N+L D Sbjct: 297 HYLD-GVDLVDSISMNAHKWLLSNLDCCFLWLQSPNALIESLAAEANFLKGGSEMVDYKD 355 Query: 314 FTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGV 373 + ++ S+ + I + + R G + + + E + +RF IV Sbjct: 356 WQISLSRR-FRAIKMWMVIRRYGVSNLIEHIRSDVSMAVRFEEMVAADDRFEIV-FPRKF 413 Query: 374 PLVAFSLKD------SSCHTEFEISDMLRRYG-WIVPAYTMPPNAQHITVLRVVIREDFS 426 LV F L E+ + + G + M V+ + E+ Sbjct: 414 ALVCFKLSSEKTPPGRDSELTRELMERVNSSGKAYLSGVQMGRIFFIRCVIGSSLTEERH 473 Query: 427 RTLAERLVIDIEKVM 441 RL+ + + + Sbjct: 474 VDNLWRLIQETAQSI 488 >2QMA-A nrPDB Length = 497 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 47/306 (15%), Positives = 119/306 (38%), Gaps = 39/306 (12%) Query: 88 DEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFK-RKWQNKRK 146 D+ T ++ + VN + + + +E A G+ T G +++ + + + Sbjct: 133 DQASSATYVEQKVVNWLCDKY----DLSEKADGIFTSGGTQSNQMGLMLARDWIADKLSG 188 Query: 147 AEGKPVDKP------NIVTGANVQVCWEKFARYFEV-ELKEVKLSEGY-YVMDPQQAVDM 198 + + P IV +K A + + E + + MD + ++ Sbjct: 189 HSIQKLGLPDYADKLRIVCSKKSHFTVQKSASWMGLGEKAVMTVDANADGTMDITKLDEV 248 Query: 199 VDENTI------CVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIA 252 + + + G+T +G +D+ + D+ V+ D +HVD A GG + Sbjct: 249 IAQAKAEGLIPFAIVGTAGTTDHGAIDDLDFIADMAVKH------DMWMHVDGAYGGALI 302 Query: 253 PFLYPELEWDFRLPLVK---SINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGA 309 + RL V+ SI+V HK G ++ +K + + L+ H +YL Sbjct: 303 LSSHKS-----RLKGVERAHSISVDFHKLFYQTISCGALLVNDKSNF-KFLLHHADYLNR 356 Query: 310 DQPTF--TLNFSKGSSQ---VIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERF 364 + ++ S +++ + + + +G + ++ ++ + + + + ++F Sbjct: 357 EHDELPNLVDKSIATTKRFDALKVFMTMQNVGPKALGDMYDHLLAQTLEVADMIRTNDQF 416 Query: 365 NIVSKD 370 ++++ Sbjct: 417 ELLAEP 422 >2OKK-A nrPDB Length = 497 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 57/344 (16%), Positives = 122/344 (35%), Gaps = 36/344 (10%) Query: 76 IMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGL 135 + S+ N N + PV L+ + + + P + G+ + G + + M A + Sbjct: 109 LTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWP---GGSGDGIFSPGGAISNMYAMM 165 Query: 136 AFKRKWQNKRKAEGKPVDKPNIVT--GANVQVCWEKFARYFEV---ELKEVKLSEGYYVM 190 + K + K +G P ++ + +K A + + +K E ++ Sbjct: 166 IARFKMFPEVKEKGMA-ALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMI 224 Query: 191 DPQQAVDMVDENTICVAA-----ILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDA 245 +++ G+T+ G F+ + + D+ + + +HVDA Sbjct: 225 PSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKK------YKIWMHVDA 278 Query: 246 ASGGFIAPFLYPELEWDFR-LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHI 304 A GG + + + +W + S+ + HK V ++ R + + H Sbjct: 279 AWGGGLL--MSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHA 336 Query: 305 NYLGADQPTFTLNFSKG-----SSQ---VIAQYYQLIRLGHEGYRNVMENCRENMIVLRE 356 +YL + L++ G + V + G G+ ++ C E L Sbjct: 337 SYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYN 396 Query: 357 GLEKTERFNIVSKDEGVPL---VAFSLKDSSCHTEFEISDMLRR 397 ++ E + +V +G P V F S T + + + R Sbjct: 397 IIKNREGYEMVF--DGKPQHTNVCFWYIPPSLRTLEDNEERMSR 438 >6JRL-A nrPDB Length = 510 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 76/392 (19%), Positives = 140/392 (35%), Gaps = 42/392 (10%) Query: 91 PVTTELQNRCVNMIAHLFNAPL----EEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRK 146 P TEL+ ++ +A P GV +SEA+++A LA + + + Sbjct: 109 PACTELEVVVMDWLAKFLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYR 168 Query: 147 AEGKPVDKPNI------VTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 + + + + C EK + ++ + E +V+ ++ Sbjct: 169 ESHPELSESEVRGRLVAYSSDQSNSCIEKAGVLAAMPIRLLPAGED-FVLRGDTLRGAIE 227 Query: 201 ENT------ICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 E+ + A LG+T ++D++ L+ + E + +HVDAA G F Sbjct: 228 EDVAAGRIPVICVATLGTTGTCAYDDIESLSAVCEE------FKVWLHVDAAYAG--GAF 279 Query: 255 LYPELEWDFR--LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQ- 311 E D R L V S+N + HK+ LV + R+ + + YL Sbjct: 280 ALEECS-DLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDSFNVDRIYLKHKHE 338 Query: 312 -PTFTLNFSK---GSS---QVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERF 364 + +F + + + LG EG RN + E + + K RF Sbjct: 339 GQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRF 398 Query: 365 NIVSKDEGVPLVAFSLKDSSCHTEFEISDML-RRYGWIVPAYTMPPNAQHITVLRVVIRE 423 +V+ + LV F K + T + ++ R+ ++V A V Sbjct: 399 ELVA-PRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFVV----CGM 453 Query: 424 DFSRTLAERLVIDIEKVMRELDELPSRVIHKI 455 D + + +IE + +L S V K Sbjct: 454 DTKASDIDFAWQEIESQLTDLQAEQSLVARKS 485 >4OBV-D nrPDB Length = 490 Score = 81.7 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 46/312 (14%), Positives = 104/312 (33%), Gaps = 37/312 (11%) Query: 75 LIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAG 134 ++ S+ N + P+ ++ + +A GV G S A + A Sbjct: 112 IMTSAYNIHAGGSKLAPMVNCIEQEVLKWLAKQVGFTENPG----GVFVSGGSMANITAL 167 Query: 135 LAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEV---ELKEVKLSEGYYVMD 191 A + K + K R + ++ + + ++ MD Sbjct: 168 TAARD-----NKLTDINLHLGTAYISDQTHSSVAKGLRIIGITDSRIRRIP-TNSHFQMD 221 Query: 192 PQQAVDMVDENT------ICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDA 245 + + ++ + V G+T G + + ++ L + D H+D Sbjct: 222 TTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCKKH------DMWFHIDG 275 Query: 246 ASGGFIAPFLYPELEWDFRLPLV-KSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHI 304 A G + L P+ + + SI+ HK+ G V+ ++ +L + Sbjct: 276 AYGASVL--LSPKYKSLLTGTGLADSISWDAHKWLFQTYGCAMVLVKDIRNLFHSFHVNP 333 Query: 305 NYL--------GADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLRE 356 YL + + ++ ++ + + L LG + + +E+ + + E Sbjct: 334 EYLKDLENDIDNVNTWDIGMELTRP-ARGLKLWLTLQVLGSDLIGSAIEHGFQLAVWAEE 392 Query: 357 GLEKTERFNIVS 368 L + + IVS Sbjct: 393 ALNPKKDWEIVS 404 >3RBF-A nrPDB Length = 480 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 72/386 (18%), Positives = 145/386 (37%), Gaps = 52/386 (13%) Query: 91 PVTTELQNRCVNMIAHLFNAPL----EEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRK 146 P TEL+ ++ + + P E+A GV +SEA ++A LA + K ++ + Sbjct: 109 PACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQ 168 Query: 147 AEGKPVDKPNIV------TGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 A + + I+ + E+ V+LK + G + M + ++ Sbjct: 169 AASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSD-GNFAMRASALQEALE 227 Query: 201 ENTIC------VAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 + + A LG+T F+++ + + ++ D +HVDAA G + F Sbjct: 228 RDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKE------DIWLHVDAAYAG--SAF 279 Query: 255 LYPELEWDFR--LPLV---KSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLG- 308 + PE FR L V S N + HK+ LV + + + DL YL Sbjct: 280 ICPE----FRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKH 335 Query: 309 --------ADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 D + + + + + ++ G +G + + + + + Sbjct: 336 SHQDSGLITDYRHWQIPLGRR-FRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQ 394 Query: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTM-PPNAQHITVLR- 418 RF I + + LV F LK S+ ++++ L + + P + + VLR Sbjct: 395 DPRFEI-CVEVILGLVCFRLKGSN-----KVNEALLQRINSAKKIHLVPCHLRDKFVLRF 448 Query: 419 VVIREDFSRTLAERLVIDIEKVMREL 444 + +R I+++ ++ Sbjct: 449 AICSRTVESAHVQRAWEHIKELAADV 474 >5O5C-A nrPDB Length = 519 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 88/265 (33%), Gaps = 36/265 (13%) Query: 63 FVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVG 122 + + IM+++N + D+ T ++ + ++ P G+ Sbjct: 111 NCPVVLPSLLAEQIMAAVNSSVDTWDQSAGGTLIEQKVIDWTLSRIGLPAGAD----GIF 166 Query: 123 TVGSSEAIMLAGLAFKRKWQNKR------KAEGKPVDKPN--IVTGANVQVCWEKFARYF 174 T G +++ ++A L + W K G P D + T +K Sbjct: 167 TSGGTQSNLMAMLLARDSWCAAHHPGHLIKHRGLPHDAAKWRVFTSKLSHFSIQKSMAIL 226 Query: 175 EVEL-KEVKLS-EGYYVMDPQQAVDMVDE------NTICVAAILGSTLNGEFEDVKLLND 226 + + + + Y MD V + V A G+T G + + +++ Sbjct: 227 GLGYDAVIPVDYDERYRMDVDCLKQEVQRCLQQGLIPVAVVATSGTTDFGSIDPLGAISE 286 Query: 227 LLVEKNKETGWDTPIHVDAASG-GFIAPFLYPELEWDFRLPLV---KSINVSGHKYGLVY 282 L +HVDAA G G + + RL + S+ V HK Sbjct: 287 LCKHHG------MWMHVDAAYGCGLLVSESHRP-----RLAGIEKADSVTVDYHKSFFQT 335 Query: 283 AGIGWVIWRNKEDLPEELIFHINYL 307 G R+K L + H +YL Sbjct: 336 VSCGAFFVRDKHHLSH-VTHHADYL 359 >4E1O-A nrPDB Length = 481 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 67/374 (17%), Positives = 136/374 (36%), Gaps = 48/374 (12%) Query: 91 PVTTELQNRCVNMIAHLFNAPLE-----EAETAVGVGTVGSSEAIMLAGLAFKRKWQNKR 145 P TEL+ ++ +A + P + GV SE+ ++A LA ++ + Sbjct: 114 PACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEM 173 Query: 146 KAEGKPVDKP----NIVTGAN--VQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMV 199 K D+ +V A+ EK V++K + + + + + + Sbjct: 174 KTSEPDADESSLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVD-DNFSLRGEALQKAI 232 Query: 200 DENT------ICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAP 253 +E+ + V A LG+T F+ + L + + +H+DAA G Sbjct: 233 EEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREG------LWLHIDAAYAG--TA 284 Query: 254 FLYPELEWDFR--LPLV---KSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLG 308 FL PE FR L + S + K+ +V+ ++K L + + YL Sbjct: 285 FLCPE----FRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLR 340 Query: 309 ADQPTFTLNFSK---GSS---QVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTE 362 +F S + + ++ + G + + + + E + Sbjct: 341 HANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDP 400 Query: 363 RFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIR 422 F I +K + LV F LK + TE + ++ + + +P Q ++R + Sbjct: 401 SFEIPAKRH-LGLVVFRLKGPNSLTENVLKEIAKAG----RLFLIPATIQDKLIIRFTVT 455 Query: 423 EDFSRTLAERLVID 436 F+ + ++ D Sbjct: 456 SQFTT--RDDILRD 467 >2OKJ-A nrPDB Length = 504 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 50/324 (15%), Positives = 110/324 (33%), Gaps = 30/324 (9%) Query: 74 KLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLA 133 + + S+ N N + PV ++ + + + ++ G+ + G + + M + Sbjct: 111 EWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVG---WSSKDGDGIFSPGGAISNMYS 167 Query: 134 GLAFKRKWQNKRKAEGKPVDKPNIV--TGANVQVCWEKFARYFEV---ELKEVKLSEGYY 188 +A + K+ + K +G P +V T +K + +K +E Sbjct: 168 IMAARYKYFPEVKTKGMA-AVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGK 226 Query: 189 VMDPQQAVDMVDENTICVAA-----ILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHV 243 ++ +++ G+T+ G F+ ++ + D+ + N +HV Sbjct: 227 IIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYN------LWLHV 280 Query: 244 DAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDL---PEEL 300 DAA GG + + + + S+ + HK V ++ + K L + Sbjct: 281 DAAWGGGLLMSRKHRHKLN-GIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMC 339 Query: 301 IFHINYLGADQPTFTLNFSKG--SSQVIAQ---YYQLIRLGHEGYRNVMENCRENMIVLR 355 ++ K + + + G G+ N + C E L Sbjct: 340 AGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLY 399 Query: 356 EGLEKTERFNIVSKDE-GVPLVAF 378 ++ E F +V E V F Sbjct: 400 AKIKNREEFEMVFNGEPEHTNVCF 423 >6ENZ-A nrPDB Length = 530 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 73/496 (14%), Positives = 158/496 (31%), Gaps = 73/496 (14%) Query: 9 ESDVSVHSTFASRYVRTSLPRFKMPENSI--------PKEAAYQIINDELMLDGNPRLNL 60 ++DV F R + + + P E Q+++ E+ G + L Sbjct: 48 QTDVKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWQPPEQLRQLLDLEMRDTGESQDKL 107 Query: 61 ASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLE------- 113 + N+ Y +D Y + + +N + + Sbjct: 108 LKLCQDVIHFSVKTNHPRFFNQLYAGLDYYSLAARIITEALNPSIYTYEVSPVFLLVEEA 167 Query: 114 ---------EAETAVGVGTVGSSEAIMLAG-LAFKRKWQNKRKAEGKPVDKPNIVTGANV 163 + G+ G S + M A LA R + ++ + + + T A Sbjct: 168 VLKKMIECVGWKEGDGIFNPGGSVSNMCAMNLARYRHCPDIKEKGLSGLPRLILFTSAEC 227 Query: 164 QVCWEKFARYFEV---ELKEVKLSEGYYVMDPQQAVDMVDENTICVAA-----ILGSTLN 215 +K A + + + V+ ++ + G+T+ Sbjct: 228 HYSMKKAASFLGIGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCATSGTTVL 287 Query: 216 GEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSG 275 G F+ + + ++ +HVDA+ GG + S+ + Sbjct: 288 GAFDPLDEIAEVCERHG------LWLHVDASWGGSALV-SRKHRRLLHGIHRADSVAWNP 340 Query: 276 HKYGLVYAGIGWVIWRNKEDL-------------PEELIFHINYLGADQPTFTLNFSKGS 322 HK + ++ ++K DL ++ + ++Y D+ ++ S+ Sbjct: 341 HKMLMAGIQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDK---SIQCSRRP 397 Query: 323 SQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVAF---- 378 + LG G + L + ++K E F ++ + E V F Sbjct: 398 D-AFKFWMTWKALGTSGLEERVNRAFALSRYLVDEIKKREGFKLLMEPE-YTNVCFWYIP 455 Query: 379 -SLKDSSCHTEF---------EISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRT 428 SL++ EF I + + + G ++ Y P + +VVI SR Sbjct: 456 PSLREMEEGPEFWRKLSLVAPAIKEKMMKKGSLMLGYQ-PHRGKVNFFRQVVISPQVSRE 514 Query: 429 LAERLVIDIEKVMREL 444 + L+ +I+ + R++ Sbjct: 515 DMDFLLDEIDSLGRDM 530 >2JIS-A nrPDB Length = 515 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 119/342 (34%), Gaps = 31/342 (9%) Query: 74 KLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLA 133 ++I S+N + + PV ++ + + L + G+ G S + M A Sbjct: 127 RIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALV-----GWSSGDGIFCPGGSISNMYA 181 Query: 134 G-LAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEV---ELKEVKLSEGYYV 189 LA +++ + ++ + + + T +K A + + ++ VK E + Sbjct: 182 VNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKM 241 Query: 190 MDPQQ-----AVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVD 244 + + V+A G+T+ G F+ ++ + D+ +HVD Sbjct: 242 VPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHG------LWLHVD 295 Query: 245 AASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHI 304 AA GG + D + S+ + HK ++ ++ +L + Sbjct: 296 AAWGGSVLLSQTHRHLLD-GIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQ 354 Query: 305 -NYLGADQPTFTLNFSKG-----SSQVIAQ---YYQLIRLGHEGYRNVMENCRENMIVLR 355 +YL + + G + + + G +G ++ L Sbjct: 355 ASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLV 414 Query: 356 EGLEKTERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRR 397 E ++K E F +V + E V V F S + E D R Sbjct: 415 EEMKKREGFELVMEPEFV-NVCFWFVPPSLRGKQESPDYHER 455 >1JS3-A nrPDB Length = 486 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 73/369 (19%), Positives = 133/369 (36%), Gaps = 57/369 (15%) Query: 91 PVTTELQNRCVNMIAHLFNAPLE----EAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRK 146 P TEL+ ++ + + P EA GV +SEA ++A LA + K + + Sbjct: 109 PACTELETVMMDWLGKMLQLPEAFLAGEAGEGGGVIQGSASEATLVALLAARTKVVRRLQ 168 Query: 147 AEGKPVDK----PNIVTGAN--VQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 A + + +V A+ E+ V+LK + G + M + ++ Sbjct: 169 AASPGLTQGAVLEKLVAYASDQAHSSVERAGLIGGVKLKAIPSD-GKFAMRASALQEALE 227 Query: 201 ENTIC------VAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 + V A LG+T F+++ + + E+ D +HVDAA G + F Sbjct: 228 RDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICHEE------DIWLHVDAAYAG--SAF 279 Query: 255 LYPELEWDFR--LPLV---KSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLG- 308 + PE FR L V S N + HK+ LV + + + DL YL Sbjct: 280 ICPE----FRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRTDLTGAFKLDPVYLKH 335 Query: 309 ADQPTFTLNFSKGSSQVIAQ-------YYQLIRLGHEGYRNVMENCRENMIVLREGLEKT 361 + Q + + + + + ++ G +G + + + + + Sbjct: 336 SHQGSGLITDYRHWQLPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFEAFVLQD 395 Query: 362 ERFNIVSKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVI 421 RF + + + LV F LK S G +A+ I ++ + Sbjct: 396 PRFEV-CAEVTLGLVCFRLKGSD--------------GLNEALLERINSARKIHLVPCRL 440 Query: 422 REDFSRTLA 430 R F A Sbjct: 441 RGQFVLRFA 449 >6EEW-A nrPDB Length = 500 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 67/344 (19%), Positives = 117/344 (34%), Gaps = 55/344 (15%) Query: 91 PVTTELQNRCVNMIAHLFNAPLEE--AETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAE 148 P TEL+ ++ +A + P + T GV +SE+I+ +A + + K + Sbjct: 130 PAATELEMIVMDWLAQILKLPKSFMFSGTGGGVIQNTTSESILCTIIAARERALEKLGPD 189 Query: 149 GKPVDKPNIVT--GANVQVCWEKFARYFEVELKEVKLSEGYYVMD----PQQAVDMVDEN 202 +V + K + + ++L D PQ MV+++ Sbjct: 190 SIG----KLVCYGSDQTHTMFPKTCKLAGIYPNNIRLIPTTVETDFGISPQVLRKMVEDD 245 Query: 203 TICVAAILGSTLNGEF--------EDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 A + L + V L+++ E IHVDAA G + Sbjct: 246 VA--AGYVPLFLCATLGTTSTTATDPVDSLSEIANEFG------IWIHVDAAYAG--SAC 295 Query: 255 LYPELEWDFR-----LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLG- 308 + PE FR + V S+++S HK+ L Y + + L L + YL Sbjct: 296 ICPE----FRHYLDGIERVDSLSLSPHKWLLAYLDCTCLWVKQPHLLLRALTTNPEYLKN 351 Query: 309 --------ADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 D + + + + + + L G ++ + + + E + Sbjct: 352 KQSDLDKVVDFKNWQIATGRK-FRSLKLWLILRSYGVVNLQSHIRSDVAMAKMFEEWVRS 410 Query: 361 TERFNIVSKDEGVPLVAFSLKDSSCHTEFE-----ISDMLRRYG 399 RF IV LV F LK E + DML G Sbjct: 411 DSRFEIV-VPRNFSLVCFRLKPDVSSLHVEEVNKKLLDMLNSTG 453 >6EEI-A nrPDB Length = 490 Score = 69.0 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 51/312 (16%), Positives = 110/312 (35%), Gaps = 34/312 (10%) Query: 91 PVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSS--EAIMLAGLAFKRKWQNKRKAE 148 P TEL+ ++ +A L N P + G G + S EA+++ +A + K Sbjct: 120 PAATELEMIVLDWVAKLLNLPEQFMSKGNGGGVIQGSASEAVLVVLIAARDKVLRSVGKN 179 Query: 149 GKPVDKPNIVTGANVQVCWEKFARYFEV---ELKEVKLSEGY-YVMDPQQAVDMVDEN-T 203 ++K + + +K + + + + Y + P+ + V + Sbjct: 180 A--LEKLVVYSSDQTHSALQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLE 237 Query: 204 ICVAAIL-----GSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPE 258 + G+T + + + L + HVDAA G + + PE Sbjct: 238 AGLIPFFLCANVGTTSSTAVDPLAALGKIANSNG------IWFHVDAAYAG--SACICPE 289 Query: 259 L-EWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLG--------- 308 ++ + S N++ HK+ L + ++++ L L + +L Sbjct: 290 YRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKDQDSLTLALSTNPEFLKNKASQANLV 349 Query: 309 ADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVS 368 D + + + + + + L G E ++ + N + + + + F IV+ Sbjct: 350 VDYKDWQIPLGRR-FRSLKLWMVLRLYGSETLKSYIRNHIKLAKEFEQLVSQDPNFEIVT 408 Query: 369 KDEGVPLVAFSL 380 LV F L Sbjct: 409 -PRIFALVCFRL 419 >5XT5-A nrPDB Length = 419 Score = 62.5 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 49/291 (16%), Positives = 93/291 (31%), Gaps = 50/291 (17%) Query: 123 TVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVC----WEKFARYFEVEL 178 T G++ ++ + L++ +A KP D +V W++ + L Sbjct: 92 TKGTTTSLNMVALSY-------ARANLKPGD--EVVITYMEHHANIIPWQQAVKATGATL 142 Query: 179 KEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWD 238 K + L E + + + V NT VA S + G +K + + + Sbjct: 143 KYIPLQED-GTISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAV---- 197 Query: 239 TPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRN---KED 295 I VD A P ++ D + +S HK G+G + + + Sbjct: 198 --IVVDGAQST-------PHMKIDVQDLDCDFFALSSHKM-CGPTGVGVLYGKKALLENM 247 Query: 296 LPEELIF-HINYLGA------------DQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRN 342 P E I+++G + T + I + L G Sbjct: 248 EPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAG------AIGLGAAIDFLEEIGLDE 301 Query: 343 VMENCRENMIVLREGLEKTERFNIVSKDEGVPLVAFSLKDSSCHTEFEISD 393 + + + E + + + +E LV F+L D H + D Sbjct: 302 ISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVLD 352 >5WGB-A nrPDB Length = 426 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 96/278 (34%), Gaps = 44/278 (15%) Query: 65 TTWMEPECDKLIMSSINKNYVDMDE------YPVTTELQNRCVNMIAHLFNAPLEEAETA 118 TT ++P ++ + Y + + ++ R +A L A E Sbjct: 35 TTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAME-RARQQVASLIGADPREI--- 90 Query: 119 VGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYF---E 175 + T G++E+ +A R +++++K +++T C R Sbjct: 91 --IFTSGATESNNIAIKGVARFYRSRKK---------HLITTQTEHKCVLDSCRSLEAEG 139 Query: 176 VELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKET 235 ++ + + + ++D ++ + +T V+ + + G + + + + + Sbjct: 140 FQVTYLPVQK-SGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRIC------S 192 Query: 236 GWDTPIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKED 295 H DAA P +++ D +++SGHK G+G + R + Sbjct: 193 SRKVYFHTDAAQAVGKIPLDVNDMKIDL-------MSISGHKI-YGPKGVGAIYIRRRPR 244 Query: 296 LPEELIFH-----INYLGADQPTFTLNFSKGSSQVIAQ 328 + E + PT + + +V Q Sbjct: 245 VRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQ 282 >1T3I-A nrPDB Length = 420 Score = 60.6 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 75/442 (16%), Positives = 142/442 (32%), Gaps = 57/442 (12%) Query: 31 KMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECD--KLIMSSINKNY-VDM 87 ++P + + I+N E+ +G+P + L T +P KL+ N N V Sbjct: 5 QIPSLAATVRQDFPILNQEI--NGHPLVYL-DNAATSQKPRAVLEKLMHYYENDNANVHR 61 Query: 88 DEYP-VTTELQN-RCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKR 145 + V F E T ++EAI L +A+ N + Sbjct: 62 GAHQLSVRATDAYEAVRNKVAKFINARSPREIVY---TRNATEAINL--VAYSWGMNNLK 116 Query: 146 KAEGKPVDKPNIVTGANVQ----VCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDE 201 + I+T V W+ A LK V+L E D + ++ E Sbjct: 117 AGD-------EIITTVMEHHSNLVPWQMVAAKTGAVLKFVQLDE-QESFDLEHFKTLLSE 168 Query: 202 NTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYPELEW 261 T V + S G + + L + + VDA P Sbjct: 169 KTKLVTVVHISNTLGCVNPAEEIAQLAHQAGAKVL------VDACQS-------APHYPL 215 Query: 262 DFRLPLVKSINVSGHKYGLVYAGIGWVIWRNK--EDLPEEL--------IFHINYLGADQ 311 D +L + SGHK GIG++ + + E +P +F ++ + Sbjct: 216 DVQLIDCDWLVASGHKM-CAPTGIGFLYGKEEILEAMPPFFGGGEMIAEVFFDHFTTGEL 274 Query: 312 PTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNI--VSK 369 P + ++ IA + L G N+ E L +GL + + + + Sbjct: 275 PHKFEAGTPAIAEAIALGAAVDYLTDLGMENIHNYEVELTHYLWQGLGQIPQLRLYGPNP 334 Query: 370 DEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHIT-----VLRVVIRED 424 G S + H +++ M+ + G + + H R + Sbjct: 335 KHGDRAALASFNVAGLHAS-DVATMVDQDGIAIRSGHHCTQPLHRLFDASGSARASLYFY 393 Query: 425 FSRTLAERLVIDIEKVMRELDE 446 ++ + + ++ +R + Sbjct: 394 NTKEEIDLFLQSLQATIRFFSD 415 >1ECX-A nrPDB Length = 384 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 40/168 (23%), Positives = 66/168 (39%), Gaps = 16/168 (9%) Query: 127 SEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCW---EKFARYFEVELKEVKL 183 SE + W K AE K I+T K+ ++K V + Sbjct: 62 SEIFFTSCATESINWILKTVAETFEKRKRTIITTPIEHKAVLETMKYLSMKGFKVKYVPV 121 Query: 184 SEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHV 243 V+ ++ +VDE+T V+ + + G + V+ + ++ +KNKET +HV Sbjct: 122 DS-RGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVTRIVKKKNKETL----VHV 176 Query: 244 DAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWR 291 DA PF +LE D+ + S HK+ G+G R Sbjct: 177 DAVQTIGKIPFSLEKLEVDYA-------SFSAHKF-HGPKGVGITYIR 216 >3K40-A nrPDB Length = 475 Score = 58.2 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 125/361 (34%), Gaps = 38/361 (10%) Query: 91 PVTTELQNRCVNMIAHLFNAPLE----EAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRK 146 P TEL+ ++ + + P E GV +SE+ ++A L K K + K Sbjct: 109 PACTELEVVMMDWLGKMLELPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVK 168 Query: 147 AEGKPVDKPNIV------TGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVD 200 D+ I+ E+ V+L+ V + M ++ Sbjct: 169 ELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSV--QSENHRMRGAALEKAIE 226 Query: 201 ENTI-CVAA-----ILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 ++ + LG+T + F+ + + + N IHVDAA G + F Sbjct: 227 QDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHN------LWIHVDAAYAG--SAF 278 Query: 255 LYPELEWDFR-LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPT 313 + PE + + S N + HK+ LV + ++ + YL D Sbjct: 279 ICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQG 338 Query: 314 FTLNFSK---GSS---QVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIV 367 ++ + + ++ L G E + + + RF + Sbjct: 339 SAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFE-L 397 Query: 368 SKDEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSR 427 + + + LV F LK S+ E + + R + +P + + LR+ I F++ Sbjct: 398 AAEINMGLVCFRLKGSNERNEALLKRINGRGHIHL----VPAKIKDVYFLRMAICSRFTQ 453 Query: 428 T 428 + Sbjct: 454 S 454 >6EEM-B nrPDB Length = 512 Score = 58.2 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 54/326 (16%), Positives = 112/326 (34%), Gaps = 46/326 (14%) Query: 91 PVTTELQNRCVNMIAHLFNAPLE-----EAETAVGVGTVGSS-EAIMLAGLAFKRKWQNK 144 P TEL++ +N + + P + + G G++ EAI+ A + K NK Sbjct: 128 PAATELESIVMNWLGQMLTLPKSFLFSSDGSSGGGGVLQGTTCEAILCTLTAARDKMLNK 187 Query: 145 RKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMD----PQQAVDMV- 199 E ++K + +K A+ + K V+ + + P + Sbjct: 188 IGRE--NINKLVVYASDQTHCALQKAAQIAGINPKNVRAIKTSKATNFGLSPNSLQSAIL 245 Query: 200 DENTICVAA-----ILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPF 254 + + +G+T + + + L + + +H+DAA G + Sbjct: 246 ADIESGLVPLFLCATVGTTSSTAVDPIGPLCAVAK------LYGIWVHIDAAYAG--SAC 297 Query: 255 LYPELEWDFR-----LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGA 309 + PE FR + S +++ HK+ + ++ + L + L YL Sbjct: 298 ICPE----FRHFIDGVEDADSFSLNAHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKN 353 Query: 310 ---------DQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEK 360 D + + S+ + + + L G R + + + + + Sbjct: 354 KATESKQVIDYKDWQIALSRR-FRSMKLWLVLRSYGVANLRTFLRSHVKMAKHFQGLIGM 412 Query: 361 TERFNIVSKDEGVPLVAFSLKDSSCH 386 RF IV +V F LK ++ Sbjct: 413 DNRFEIV-VPRTFAMVCFRLKPTAIF 437 >4ISY-A nrPDB Length = 404 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 66/178 (37%), Gaps = 31/178 (17%) Query: 123 TVGSSEAIMLAGLAFKRKWQ----NKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVEL 178 T G +E+ LA + ++R+ V+ ++ N V + + Sbjct: 76 TAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLV------EHEGAHV 129 Query: 179 KEVKLSEGYYVMDPQQAVDMVD--ENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETG 236 + + + + + ++ V+ + + G + ++ + +E Sbjct: 130 TWLPTAAD-GSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFG---- 184 Query: 237 WDTPIHVDA--ASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRN 292 P+H DA A G +L DF + +++V+GHK+G G+G ++ R Sbjct: 185 --VPMHSDAIQAVG---------QLPLDFGASGLSAMSVAGHKFG-GPPGVGALLLRR 230 >4EB7-A nrPDB Length = 382 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 48/285 (16%), Positives = 105/285 (36%), Gaps = 46/285 (16%) Query: 60 LASFVTTWMEPECDKLIMSSI--------NKNYVDMDEYPVTTELQNRCVNMIAHLFNAP 111 +A F T +P ++++ + + N + V + +Q +A L N Sbjct: 1 MAYFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQ-EAREKVAKLVNG- 58 Query: 112 LEEAETAVGVGTVGSSEAIMLAGLAFKRK-WQNKRKAEGKPVDKPNIVTGANVQVCWEKF 170 V T G++EA LA + + + + + V+ +++ A KF Sbjct: 59 ----GGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPA-------KF 107 Query: 171 ARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVE 230 + E++ + + + Y +D + ++TI V+ + G + V+ ++++L Sbjct: 108 LQKQGFEVEYIPVGK-YGEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVLAG 166 Query: 231 KNKETGWDTPIHVDA-ASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVI 289 K +H+DA AS G ++E D + +S + G+G + Sbjct: 167 KAA-------LHIDATASVG--------QIEVDVEKIGADMLTISSNDI-YGPKGVG-AL 209 Query: 290 WRNKEDLPEELIFHINYLGADQPT-----FTLNFSKGSSQVIAQY 329 W KE + +I + + F K + ++ Sbjct: 210 WIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITAMEW 254 >3GZD-A nrPDB Length = 440 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 61/423 (14%), Positives = 143/423 (33%), Gaps = 55/423 (13%) Query: 63 FVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVG 122 TT +EPE + + ++ + + + P + + + + A A + + + Sbjct: 32 NATTPLEPEVIQAMTKAMWEAWGNPSS-PYSAGRKAKDIINAARESLAKMIGGKPQDIIF 90 Query: 123 TVGSSEAIMLAGLAFKRKW------QNKRKAEGKPVD--KPNIVTGANVQVCWEKFARYF 174 T G +E+ L + + + + PV KP+ +T + + Sbjct: 91 TSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHL 150 Query: 175 EVE----LKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLN----D 226 E + V +S+ + + V T V +L + G V ++ Sbjct: 151 VEEQVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKA 210 Query: 227 LLVEKNKETGWDTPIHVDA--ASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAG 284 L E+ +H DA A G + D V + + GHK+ Sbjct: 211 LNQERVAAGLPPILVHTDAAQALG---------KQRVDVEDLGVDFLTIVGHKF-YGPRI 260 Query: 285 IGWVIWRNKEDLP-EELIF----HINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEG 339 I E P ++F N+ + T + +++++ Q + +E Sbjct: 261 GALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCE----AYEA 316 Query: 340 YRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVA-FSLKDSSCHTEFEI------- 391 + + + E + G ++ + + +P FS++ + Sbjct: 317 HMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLM 376 Query: 392 --------SDMLRRYGWIVPAYTMPPNAQHITVLRVVIREDFSRTLAERLVIDIEKVMRE 443 SD + ++ +Y +P + LR+ + +R + +V D+++ + + Sbjct: 377 ASVGAACHSDHGDQPSPVLLSYGVPFDVA-RNALRLSVGRSTTRAEVDLVVQDLKQAVAQ 435 Query: 444 LDE 446 L++ Sbjct: 436 LED 438 >3A9Z-A nrPDB Length = 432 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 82/247 (33%), Gaps = 29/247 (11%) Query: 55 NPRLNLASFVTTWMEPECDKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEE 114 N ++ + TT +EPE + + ++ + + + V +N + Sbjct: 17 NRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGG 76 Query: 115 AETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDK--------PNIVTGANVQVC 166 + + T G +E+ L + R + ++ +G+ VD+ P+ +T Sbjct: 77 KPQDI-IFTSGGTESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDS 135 Query: 167 WEKFARYFE----VELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVK 222 + E+ V +S+ ++ + + V T V +L + G + Sbjct: 136 IRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPIS 195 Query: 223 LLNDLLVEKN----KETGWDTPIHVDA--ASGGFIAPFLYPELEWDFRLPLVKSINVSGH 276 ++ + N +H DA A G + D V + + GH Sbjct: 196 EISRRIKALNQIRAASGLPRVLVHTDAAQALG---------KRRVDVEDLGVDFLTIVGH 246 Query: 277 KYGLVYA 283 K+ Sbjct: 247 KF-YGPR 252 >5HH9-A nrPDB Length = 390 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 49/359 (13%), Positives = 108/359 (30%), Gaps = 50/359 (13%) Query: 43 YQIINDELMLDGNPRLNLASFVTTWMEPECDKLIM---SSINKNYVDMDEYPV--TTELQ 97 ++ + + LD L+ A+F+ T + I ++N + ++ + + Sbjct: 3 WKALRQQFDLDPQ-YLHFANFLLTSHPRPVREAIERLRVRFDRNPGEAVDWHREEIWKYE 61 Query: 98 NRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKP-- 155 + F A G T G A G + +P Sbjct: 62 DEARAWAGRYF-AVQPGQVALTGSTTDG--------LAAIY----------GGLLVQPGK 102 Query: 156 NIVTGANVQVCWEKFARY----FEVELKEVKLSEGYYVMDPQQAVDMVD----ENTICVA 207 I+T ++ Y +++E L + + + + + + T + Sbjct: 103 EILTSSHEHYSTYTTLEYRHKRMGTQVREFPLFKDPHRVSADEILSSIAAQIRPQTRVLG 162 Query: 208 AILGSTLNGEFEDVKLLNDLLVEKN--KETGWDTPIHVDAASGGFIAPFLYPELEW-DFR 264 + +G ++ + L+ E N ++ VD G F ++ + DF Sbjct: 163 MTWVQSGSGVKLPIREIGKLVRELNQKRDEQDRIIYVVDGVHG-----FGVEDVSFADF- 216 Query: 265 LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGAD-QPT-FTLNFSKGS 322 HK+ G G +I R+++ + + AD T T Sbjct: 217 --DCDYFIAGTHKWLFGPRGTGVIIARSEQLQEHLVPSIPTFSRADNFGTLMTPGGYHAF 274 Query: 323 SQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVAFSLK 381 +A G V + L++ L + + +V+ P ++ Sbjct: 275 EHRLALGTAFELHLQLGKAEVQARIHQLNAYLKQRLGEHPKVRLVTPTS--PELSSGFT 331 >3ELE-A nrPDB Length = 398 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 86/264 (32%), Gaps = 38/264 (14%) Query: 156 NIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLN 215 +T A ++ F L EV ++ +D + ++ +T V + + Sbjct: 126 EFITIAPYFPEYKVFVNAAGARLVEVPADTEHFQIDFDALEERINAHTRGVIINSPNNPS 185 Query: 216 GEF---EDVKLLNDLLVEKNKETGWDTPIHVDA-----ASGGFIAPFL---YPELEWDFR 264 G E +K L+DLL +K+KE G I D G PF+ Y + Sbjct: 186 GTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEPYREIVYDGIKVPFVTKYYDNTLVCYS 245 Query: 265 LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTF--------TL 316 KS+++ G + G V+ ++ EL + G + Sbjct: 246 YS--KSLSLPGERIGY-------VLVPDEVYDKAELYAAVCGAGRALGYVCAPSLFQKMI 296 Query: 317 NFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLV 376 +G++ I Y + L +EG + +C + ++ E + Sbjct: 297 VKCQGATGDINAYKENRDLLYEGLTRIGYHCFKPDGAFYMFVKALE--------DDSNAF 348 Query: 377 AFSLKDSSCHTEFEISDMLRRYGW 400 K+ +D GW Sbjct: 349 CEKAKEED--VLIVAADGFGCPGW 370 >4K2M-A nrPDB Length = 443 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 54/166 (32%), Gaps = 30/166 (18%) Query: 123 TVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVK 182 T ++AIM+ LA P D ++ AN E V Sbjct: 124 TSSGTDAIMIGLLAL----------GLNPGD--EVIMPANSFSATENAVLASGGVPIYVD 171 Query: 183 LSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIH 242 ++ + +DP + + + T + L L G+ D++ + + + + Sbjct: 172 INPQTFCIDPDKIEEAITPYTKFI---LPVHLYGKHSDMQHIRQIANR------YKLKVI 222 Query: 243 VDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHK-YGLVYAGIGW 287 DA G + + + +++ + +K +G+ Sbjct: 223 EDACQGIGLTDLG--------KYADITTLSFNPYKNFGVCGKAGAI 260 >2C81-A nrPDB Length = 418 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 48/160 (30%), Gaps = 22/160 (13%) Query: 73 DKLIMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIML 132 K+ + + + ++ + A + V T S A+ML Sbjct: 20 RKIEEVFQSNRWAISGYWTGEESMERKFAK-------AFADFNGVPYCVPTTSGSTALML 72 Query: 133 AGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDP 192 A A EG V P++ A A V + Y +DP Sbjct: 73 ALEALGI-------GEGDEVIVPSLTWIATATAVLNVNAL-----PVFVDVEADTYCIDP 120 Query: 193 QQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKN 232 Q + + T + L G ++ +N++ E N Sbjct: 121 QLIKSAITDKTKAII---PVHLFGSMANMDEINEIAQEHN 157 >6C9E-A nrPDB Length = 422 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 51/301 (16%), Positives = 98/301 (32%), Gaps = 58/301 (19%) Query: 125 GSSEAI-MLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKL 183 G++EAI ++A + + ++ + + W+ + +L+ + Sbjct: 109 GTTEAINLVAQSLVAPRILPDEEILITHMEHHSNIVP------WQMVCKKMGCKLQVAPI 162 Query: 184 SEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHV 243 S V+ + ++ENT VA S G VK + + E + + Sbjct: 163 SLNGEVILEEFERK-LNENTKMVAINYASNSLGTINPVKTMIKMAHEVGAKVL------L 215 Query: 244 DAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFH 303 D A +L+ DF SGHK GIG V+W +E L Sbjct: 216 DGAQATAHLIVDVQDLDCDF-------YAFSGHKM-YGPTGIG-VLWGKEELLNS----M 262 Query: 304 INYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRN--------------------- 342 Y G + +++F +Y + G N Sbjct: 263 TPYQGGGEMINSVSFE------ATEYAAIPHKFEAGTPNIAGAIGLAAAIDYIWSLDLDA 316 Query: 343 VMENCRENMIVLREGLEKTERFNIVSK-DEGVPLVAF---SLKDSSCHTEFEISDMLRRY 398 + E + + + +E + +NI+ VP+++F + T + + R Sbjct: 317 IAEYETQLLNYATKAIEAVKGYNIIGTAANKVPIISFVHGKIHAHDIGTILDSEGIAIRS 376 Query: 399 G 399 G Sbjct: 377 G 377 >5YHV-A nrPDB Length = 394 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 27/108 (25%), Gaps = 13/108 (12%) Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 V T GSS +LA LA A C+ E+ E Sbjct: 101 VITTGSSGGFLLAFLACFDAGDRVAMASP-------------GYPCYRNILSALGCEVVE 147 Query: 181 VKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLL 228 + Q + +D V + G + L + Sbjct: 148 IPCGPQTRFQPTAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIA 195 >3NYS-A nrPDB Length = 367 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 26/83 (31%), Gaps = 3/83 (3%) Query: 156 NIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLN 215 ++T V + + V + Y +DPQ + T + +L Sbjct: 77 EVITPGFTYVATAETVALLGAKPVYVDIDPRTYNLDPQLLEAAITPRTKAII---PVSLY 133 Query: 216 GEFEDVKLLNDLLVEKNKETGWD 238 G+ D +N + + D Sbjct: 134 GQCADFDAINAIASKYGIPVIED 156 >1WYV-B nrPDB Length = 474 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 44/339 (12%), Positives = 108/339 (31%), Gaps = 39/339 (11%) Query: 85 VDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNK 144 + + P T + R + + A A+ + + + L + +++ Sbjct: 93 LHPYQDPRTAQGALRLMWELGEYLKA--LTGMDAITLEPAAGAHGELTGILIIRAYHEDR 150 Query: 145 RKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTI 204 + + V ++ + A +++E+ +D + + + Sbjct: 151 GEGRTRRV----VLVPDSAHGSNPATASMAGYQVREIPSGPE-GEVDLEALKRELGPHVA 205 Query: 205 CVAAILGSTLNGEFED-VKLLNDLLVEKNKETGWDTPIHVDAASGGFIAPFLYP-ELEWD 262 + +TL G FE + ++ L E ++ D A+ I + P ++ +D Sbjct: 206 ALMLTNPNTL-GLFERRILEISRLCKEAG------VQLYYDGANLNAIMGWARPGDMGFD 258 Query: 263 FRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEEL-IFHINYLGADQPTFTLNFSKG 321 ++++ HK V G G + + + F L+F + Sbjct: 259 V-------VHLNLHKTFTVPHGGGGPGSGPVGVKAHLAPYLPVPLVERGEEGFYLDFDRP 311 Query: 322 SSQ------------VIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSK 369 S ++ + + LG EG + N L+E L++ + + + Sbjct: 312 KSIGRVRSFYGNFLALVRAWAYIRTLGLEGLKKAAALAVLNARYLKELLKE-KGYRVPYD 370 Query: 370 DEGVPLVAFSLKDSSCHTEFEISDMLRRYGWIVPAYTMP 408 + F + +++ L G+ P P Sbjct: 371 GPSMHE--FVAQPPEGFRALDLAKGLLELGFHPPTVYFP 407 >1GC4-A nrPDB Length = 385 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 38/127 (29%), Gaps = 18/127 (14%) Query: 122 GTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEV 181 TVG S+A+ A V P +V R+ + EV Sbjct: 96 VTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMV-------------RFAGGVVVEV 142 Query: 182 KLSEGYYVM-DPQQAVDMVDENTICVAAILGSTLNGEFED---VKLLNDLLVEKNKETGW 237 + + DP++ + T + + G ++ L L VE + Sbjct: 143 ETLPEEGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVEHDFYLVS 202 Query: 238 D-TPIHV 243 D H+ Sbjct: 203 DEIYEHL 209 >1B9H-A nrPDB Length = 388 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 30/91 (32%), Gaps = 9/91 (9%) Query: 156 NIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLN 215 ++ A + + A+ V + Y +DP+ V T + + + Sbjct: 80 EVIVPAFTFISSSQAAQRLGAVTVPVDVDAATYNLDPEAVAAAVTPRTKVI---MPVHMA 136 Query: 216 GEFEDVKLLNDLLVEKNKETGWDTPIHVDAA 246 G D+ L + + P+ DAA Sbjct: 137 GLMADMDALAKISADTG------VPLLQDAA 161 >3UWC-A nrPDB Length = 374 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 13/65 (20%) Query: 184 SEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHV 243 SE YV+DP++ + + T AI+ G D+ L + + N +H+ Sbjct: 107 SENGYVIDPEKIEAAITDKT---KAIMPVHYTGNIADMPALAKIAKKHN--------LHI 155 Query: 244 --DAA 246 DA Sbjct: 156 VEDAC 160 >2GMS-A nrPDB Length = 390 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 39/112 (34%), Gaps = 9/112 (8%) Query: 116 ETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFE 175 + V S A +L +A + R +G + P + + + Sbjct: 48 GSKYAVMVSSGSTANLL-MIAALFFTKKPRLKKGDEIIVPAVSWSTTYYP-----LQQYG 101 Query: 176 VELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDL 227 + +K V + +D + + V ++T AIL L G + +N + Sbjct: 102 LRVKFVDIDINTLNIDIESLKEAVTDST---KAILTVNLLGNPNNFDEINKI 150 >5WMH-A nrPDB Length = 475 Score = 37.8 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 67/487 (13%), Positives = 150/487 (30%), Gaps = 66/487 (13%) Query: 8 SESDVSVHSTFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTW 67 S+S V+V S+ A+R P K P S+ + ++ + GN + + Sbjct: 3 SQSSVAVISSAAARGES--FPDSKKPIGSVRFQQPLRL-SFSYCKSGNMSSRICAMAKPN 59 Query: 68 MEPECDKLIMSSINK--NYVDMDEYPVTTELQNRCVNMIAHL---------FNAPLEEAE 116 + S++ + + V T+L V + F+ P AE Sbjct: 60 DAETLSSSVDMSLSPRVQSLKPSKTMVITDLAATLVQSGVPVIRLAAGEPDFDTPKVVAE 119 Query: 117 TAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKP--------------------- 155 + G + + AG+ R+ ++ E + Sbjct: 120 AGINAIREGFTRYTLNAGITELREAICRKLKEENGLSYAPDQILVSNGAKQSLLQAVLAV 179 Query: 156 -----NIVTGANVQVCWEKFARYFEVELKEVKLS-EGYYVMDPQQAVDMVDENTICVAAI 209 ++ A V + + AR + + +++DP+ + E + + Sbjct: 180 CSPGDEVIIPAPYWVSYTEQARLADATPVVIPTKISNNFLLDPKDLESKLTEKSRLLILC 239 Query: 210 LGSTLNGEFED---VKLLNDLLVEKNKETGW--DTPIHVDAASGGFIAPFLYPELEWDFR 264 S G ++ + ++ + + + H+ AP + Sbjct: 240 SPSNPTGSVYPKSLLEEIARIIAKHPRLLVLSDEIYEHI------IYAPATHTSFA---S 290 Query: 265 LPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLNFSKGSSQ 324 LP + ++ + + +A GW + P+ ++ + L + + ++ + Sbjct: 291 LPDMYERTLTVNGFSKAFAMTGWRL--GYLAGPKHIVAACSKLQGQVSSGASSIAQKAGV 348 Query: 325 VIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVSKDEGVPLVAFSLKD-- 382 L + G E +++ RE L + L + I S+ +G + Sbjct: 349 AAL---GLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKI-SEPQGAFYLFIDFSAYY 404 Query: 383 -SSCHTEFEISDMLRRYGWIVPAYT--MPPNAQHITVLRVVIREDFSRTLAERLVIDIEK 439 S I+D + + + M P + I S + + V I K Sbjct: 405 GSEAEGFGLINDSSSLALYFLDKFQVAMVPGDAFGDDSCIRISYATSLDVLQAAVEKIRK 464 Query: 440 VMRELDE 446 + L Sbjct: 465 ALEPLRA 471 >4PIW-A nrPDB Length = 396 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 7/77 (9%), Positives = 21/77 (27%), Gaps = 3/77 (3%) Query: 156 NIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLN 215 ++ + V ++ V + +D + + T + Sbjct: 93 EVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNIDETLIEAAITDKTRVIV---PVHYA 149 Query: 216 GEFEDVKLLNDLLVEKN 232 G ++ + L + N Sbjct: 150 GVACEMDTIMALAKKHN 166 >4M2J-A nrPDB Length = 406 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 33/127 (25%), Gaps = 17/127 (13%) Query: 121 VGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKE 180 + T GSSEAI L A + +V + + R ++ Sbjct: 106 LVTHGSSEAIALTLNALLHRGDR-------------VVVQEGIYHSLGHYPRAAGCDVAV 152 Query: 181 VKLSEGY-YVMDPQQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDT 239 + +DP +V T V G + L L Sbjct: 153 LPGRAVRDGEIDPDVLAGLVTPGTAAVIVNFPHNPTGVTLSPQGLRALKERTAATGAVLV 212 Query: 240 PIHVDAA 246 DAA Sbjct: 213 W---DAA 216 >4PFU-A nrPDB Length = 547 Score = 32.8 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 53/152 (34%), Gaps = 24/152 (15%) Query: 138 KRKWQNKRKAE--GKPVDKPNIVTGANVQV------CWEKFARYFEVELKEVKLSEGYYV 189 K W+ K + + P +E+F ++ ++ VK + Y V Sbjct: 146 KHIWEEKDETTILQSSNEYPLGSGPYVAHSWDQNKMIFERFENWWGTKVMGVKPAPKYVV 205 Query: 190 MDPQQAVDMVDENTICVAAILGSTLNGEFED----VKLLNDLLVEKNKETGWD-TPIHVD 244 + V ++ N G + GE + + + L N T +D P H+ Sbjct: 206 I-----VRVLSNNVAL-----GMLMKGELDFSNFMLPGVPILKKVYNLNTWYDEPPYHLS 255 Query: 245 AAS-GGFIAPFLYPELEWDFRLPLVKSINVSG 275 + G F+ YP +FR + SIN Sbjct: 256 STVVGLFLNARKYPLSLPEFRRAIAMSINADP 287 >3FFH-A nrPDB Length = 363 Score = 32.1 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 37/101 (36%), Gaps = 5/101 (4%) Query: 153 DKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGS 212 N V V + + A E++E+ L + D + ++ +DE T V + Sbjct: 107 TTTNTVMATPTFVQYRQNALIEGAEVREIPLLQD-GEHDLEGMLNAIDEKTTIVWICNPN 165 Query: 213 TLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDAASGGFIAP 253 G + ++ + L D + +D A ++ P Sbjct: 166 NPTGNYIELADIQAFLDR----VPSDVLVVLDEAYIEYVTP 202 >3EUC-A nrPDB Length = 367 Score = 31.7 bits (70), Expect = 0.83, Method: Composition-based stats. Identities = 9/74 (12%), Positives = 26/74 (35%), Gaps = 2/74 (2%) Query: 156 NIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAIL-GSTL 214 ++ V + A++ +E V L + +D + + E+ + + + Sbjct: 111 KVMAPVPGFVMYAMSAQFAGLEFVGVPLRAD-FTLDRGAMLAAMAEHQPAIVYLAYPNNP 169 Query: 215 NGEFEDVKLLNDLL 228 G D + ++ Sbjct: 170 TGNLFDAADMEAIV 183 >2Z9W-A nrPDB Length = 392 Score = 31.3 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 38/115 (33%), Gaps = 21/115 (18%) Query: 146 KAEGKPVDKPNIVTGANVQVCWEKFARYFEVEL------KEVKLSEGYYVMDPQQAVDMV 199 +A + P+ V + K Y+ EV +E +DPQ DM+ Sbjct: 73 EAAAASLISPDDVVLNLASGVYGKGFGYWAKRYSPHLLEIEVPYNE---AIDPQAVADML 129 Query: 200 DEN---TICVAAILGSTLNGEFEDVKLLNDLLVEKNKETGWDTPIHVDA--ASGG 249 + T+ T +G + + L+ + VDA + GG Sbjct: 130 KAHPEITVVSVCHH-DTPSGTINPIDAIGALVSAHGA------YLIVDAVSSFGG 177 >3ZXJ-A nrPDB Length = 542 Score = 31.3 bits (69), Expect = 0.96, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 43/149 (28%), Gaps = 21/149 (14%) Query: 250 FIAPFLYPELEWD---FRLPLVKSINVSGHKYGLVY---AGIGWVIWRNKEDLPEELIFH 303 F P L+ + D FR+ V + S Y V W L F Sbjct: 8 FTNPVLWEDHP-DLEVFRVGSVFYYSSSTFAYSPGAPVLKSYDLVHWTPVTHSVPRLNFG 66 Query: 304 INYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREGLEKTER 363 NY D P+ T + V + +R R C E L Sbjct: 67 SNY---DLPSGT-----PGAYVKGIWASTLRYRRSNDRFYWYGCVEGRTYLWTS----PG 114 Query: 364 FNIVSKDEGVP--LVAFSLKDSSCHTEFE 390 N ++ + VP + + + ++ Sbjct: 115 GNALANNGEVPPSAWNWQHTATIDNCYYD 143 >2EH6-A nrPDB Length = 375 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 41/124 (33%), Gaps = 17/124 (13%) Query: 126 SSEAIMLAGLAFKRKWQNKRKAEGKPVDKPNIV-------TGANVQVCWEKFARYFEVEL 178 +E++ A ++ W++K K + K + N A Q + K Sbjct: 95 GTESVEAAIKLARKYWRDKGKNKWKFISFENSFHGRTYGSLSATGQPKFHKGFEPLVPGF 154 Query: 179 KEVKLSEGYYVMDPQQAVDMVDENTICVAAILGSTLNGEF----EDVKLLNDLLVEKNKE 234 KL+ D ++DE T + + G + + L ++ EK+ Sbjct: 155 SYAKLN------DIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLSKLQEICKEKDVL 208 Query: 235 TGWD 238 D Sbjct: 209 LIID 212 >6FKK-A nrPDB Length = 578 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 37/119 (31%), Gaps = 17/119 (14%) Query: 173 YFEVELKEVKLSEGYYVMDP--QQAVDMVDENTICVAAILGSTLNGEFEDVKLLNDLLVE 230 Y++V + ++ VD V + + G ++ L + Sbjct: 402 YYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGT--PIRELVISTSK 459 Query: 231 KNKETGWD-----TPIH-----VDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYG 279 + D P+H VD G P WD + K++ S HK+G Sbjct: 460 NSLVVVSDGSLVSVPLHHCSHIVD-CLG--CLSLQDPICAWDLQTHECKNLATSQHKFG 515 >5XFM-A nrPDB Length = 642 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 11/62 (17%), Positives = 26/62 (41%), Gaps = 4/62 (6%) Query: 248 GGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYL 307 G + P + + WD V + + H Y W++W++ ++ + +I++ Sbjct: 266 GDHLKPIVETTVPWDV----VSPLYETKHDYRFGRGTWSWILWQDGSINYDDQVRYIDFA 321 Query: 308 GA 309 A Sbjct: 322 SA 323 >4LSW-A nrPDB Length = 318 Score = 29.7 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 16/126 (12%), Positives = 37/126 (29%), Gaps = 14/126 (11%) Query: 165 VCWEKFARY--FEVELKEVKLSEGYYVMDPQQAVDMVD---ENTICVAAILGSTLNGEF- 218 + +E R F++++ ++ Y D D V + + S Sbjct: 156 IGFEVARRLAGFDMQISYSDIAPKSYAPDWTFVEDAVTLARDVDFLFVTLAASAATRHIV 215 Query: 219 --EDVKLLN------DLLVEKNKETGWDTPIHVDAASGGFIAPFLYPELEWDFRLPLVKS 270 + ++ L ++ N + D G E +D R + + Sbjct: 216 GRDVIEALGPEGMLINISRASNIDEEALIAALADGRLGSAALDVFEGEPNFDPRFRDLPN 275 Query: 271 INVSGH 276 + + H Sbjct: 276 VLLQPH 281 >5V41-A nrPDB Length = 286 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 17/149 (11%) Query: 266 PLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQPTFTLNFSKGSSQV 325 PL+ + YG E+ ++ + + + D P + +S G Sbjct: 39 PLLGRLPADTPMYGFERVEGSI------EERAQQYVPKLIEMQGDGPYVLVGWSLGGVLA 92 Query: 326 IAQYYQLIRLGHE----GYRNVM---ENCRENMIVLREGLEKTERFNIVSKDEGVPLVAF 378 A L RLG + G + + E + +R+ ++ F + + +P + + Sbjct: 93 YACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPY 152 Query: 379 SL---KDSSCHTEFEISDMLRRYGWIVPA 404 D F + D + + G +PA Sbjct: 153 EQLEELDDEGQVRFVL-DAVSQSGVQIPA 180 >5ZBI-A nrPDB Length = 532 Score = 29.4 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 50/138 (36%), Gaps = 10/138 (7%) Query: 251 IAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGAD 310 I F+Y ++ +D R P +I S K VY G+ +D E + N+L Sbjct: 150 IIVFMYDDIAYDIRNPYPGTIINSPDKKD-VYKGV-------PKDYTGEDVNVQNFLAVI 201 Query: 311 QPTFTLNFSKGSSQVIAQY--YQLIRLGHEGYRNVMENCRENMIVLREGLEKTERFNIVS 368 T + + + I GY V+ E + + ++ ++ + + Sbjct: 202 LGNKTALTGGSGKVLDTRPNDHIFIYYTDHGYPGVLGMPTEPYLYANDLIDTLKKKHALG 261 Query: 369 KDEGVPLVAFSLKDSSCH 386 EG+ + + +S Sbjct: 262 TYEGLVFYVEACESASIF 279 >6CN1-A nrPDB Length = 424 Score = 29.0 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 50/146 (34%), Gaps = 5/146 (3%) Query: 94 TELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNKRKAEGKPVD 153 +++ + A L A +V +E IM+A K + + A Sbjct: 139 AKIEVEGGYIKAKAPEGGLRGAHFFFDTVSVTGTENIMMAAALAKGRSVLQNAAR----- 193 Query: 154 KPNIVTGANVQVCWEKFARYFEVELKEVKLSEGYYVMDPQQAVDMVDENTICVAAILGST 213 +P +V AN + + + E + + D ++ T VAA + Sbjct: 194 EPEVVDLANFINAMGGNIQGAGTDTITIDGVERLDSANYRVMPDRIETGTYLVAAAVTGG 253 Query: 214 LNGEFEDVKLLNDLLVEKNKETGWDT 239 + + + ++EK KE G D Sbjct: 254 RVKVKDTDPTILEAVLEKLKEAGADI 279 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.125 0.315 Lambda K H 0.267 0.0385 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,955,167 Number of Sequences: 36641 Number of extensions: 655573 Number of successful extensions: 2045 Number of sequences better than 10.0: 64 Number of HSP's better than 10.0 without gapping: 40 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 1906 Number of HSP's gapped (non-prelim): 84 length of query: 502 length of database: 10,336,785 effective HSP length: 101 effective length of query: 401 effective length of database: 6,636,044 effective search space: 2661053644 effective search space used: 2661053644 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.2 bits)