BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q39193 (361 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3UC3-A nrPDB 743 0.0 3ZUT-A nrPDB 595 e-170 5WAX-A nrPDB 564 e-161 3UDB-A nrPDB 563 e-161 4CZT-A nrPDB 202 1e-52 3H4J-B nrPDB 200 1e-51 4D28-A nrPDB 199 1e-51 4RED-A nrPDB 193 8e-50 4REW-A nrPDB 193 1e-49 4CFH-A nrPDB 193 1e-49 4CFF-A nrPDB 192 2e-49 5EZV-A nrPDB 191 4e-49 2YZA-A nrPDB 189 2e-48 2QNJ-A nrPDB 187 5e-48 5ES1-A nrPDB 186 9e-48 5KZ7-A nrPDB 186 1e-47 4YNZ-A nrPDB 183 1e-46 3MN3-A nrPDB 181 3e-46 2HAK-A nrPDB 178 3e-45 6C9D-A nrPDB 177 5e-45 5YKS-A nrPDB 172 2e-43 3HZT-A nrPDB 166 2e-41 3DXN-A nrPDB 164 7e-41 2J90-A nrPDB 160 6e-40 4CQG-A nrPDB 160 9e-40 2BRG-A nrPDB 159 1e-39 3GUB-A nrPDB 157 5e-39 3NCG-A nrPDB 155 2e-38 4D2V-A nrPDB 155 4e-38 5JN2-A nrPDB 153 1e-37 3DFA-A nrPDB 153 1e-37 3MA6-A nrPDB 150 6e-37 5FG8-A nrPDB 150 7e-37 2JAM-A nrPDB 150 1e-36 3F3Z-A nrPDB 149 2e-36 5U6Y-A nrPDB 149 3e-36 2VZ6-A nrPDB 148 3e-36 2W4O-A nrPDB 148 3e-36 3BHH-A nrPDB 148 4e-36 2VN9-A nrPDB 147 6e-36 6CMJ-A nrPDB 147 8e-36 4FG9-A nrPDB 146 1e-35 2JC6-A nrPDB 146 2e-35 5IG1-A nrPDB 145 2e-35 3SOA-A nrPDB 145 3e-35 3D2K-A nrPDB 145 4e-35 4UZD-A nrPDB 144 4e-35 3LIJ-A nrPDB 144 6e-35 2YAB-A nrPDB 144 7e-35 2BDW-A nrPDB 143 1e-34 3KK8-A nrPDB 142 2e-34 4RGJ-A nrPDB 142 2e-34 2JDO-A nrPDB 142 2e-34 1ZWS-A nrPDB 141 3e-34 5D9K-A nrPDB 141 4e-34 3HDN-A nrPDB 141 5e-34 3KN6-A nrPDB 140 7e-34 2A27-A nrPDB 140 7e-34 4MVF-A nrPDB 140 7e-34 4YZB-A nrPDB 140 1e-33 2V7O-A nrPDB 140 1e-33 5YV8-A nrPDB 139 2e-33 3MV5-A nrPDB 138 3e-33 6FDY-U nrPDB 138 3e-33 3Q5I-A nrPDB 138 4e-33 5KCV-A nrPDB 137 5e-33 2Z7Q-A nrPDB 137 7e-33 4B8L-A nrPDB 135 4e-32 2YCR-A nrPDB 134 5e-32 5JZN-A nrPDB 134 7e-32 1KOA-A nrPDB 134 8e-32 3UTO-A nrPDB 133 1e-31 5N23-A nrPDB 131 6e-31 5XZW-A nrPDB 130 7e-31 2X4F-A nrPDB 130 7e-31 4NIF-A nrPDB 130 1e-30 4I6B-A nrPDB 130 1e-30 3I6U-A nrPDB 130 1e-30 5DYK-A nrPDB 129 1e-30 5X3F-B nrPDB 129 2e-30 2I0E-A nrPDB 129 2e-30 4JG6-A nrPDB 129 2e-30 4C0T-A nrPDB 128 3e-30 3PFQ-A nrPDB 128 4e-30 4B6L-A nrPDB 127 5e-30 4RA4-A nrPDB 127 6e-30 5F9E-A nrPDB 127 9e-30 3IS5-A nrPDB 126 1e-29 4WB7-A nrPDB 126 1e-29 4PDS-A nrPDB 126 2e-29 3TXO-A nrPDB 126 2e-29 5FET-A nrPDB 125 2e-29 6CCF-A nrPDB 125 4e-29 4AF3-A nrPDB 124 5e-29 3DB8-A nrPDB 124 5e-29 1NY3-A nrPDB 122 3e-28 2OZA-A nrPDB 122 3e-28 6QAU-A nrPDB 122 3e-28 3KA0-A nrPDB 121 4e-28 1KOB-A nrPDB 121 4e-28 1FOT-A nrPDB 121 4e-28 6E9W-A nrPDB 121 5e-28 4JXF-A nrPDB 120 6e-28 4WNO-A nrPDB 120 8e-28 6BDL-A nrPDB 118 3e-27 2OU7-A nrPDB 117 5e-27 4J52-A nrPDB 117 8e-27 3TAC-A nrPDB 117 9e-27 6ED6-A nrPDB 116 2e-26 3A8W-A nrPDB 114 7e-26 4L42-A nrPDB 114 8e-26 4RLP-A nrPDB 112 2e-25 3ORZ-A nrPDB 112 2e-25 1VZO-A nrPDB 112 2e-25 3LM0-A nrPDB 111 5e-25 4X7Q-B nrPDB 110 8e-25 2WTK-C nrPDB 109 2e-24 4APC-A nrPDB 109 2e-24 4XBR-A nrPDB 108 3e-24 2Y7J-A nrPDB 108 4e-24 6E2O-A nrPDB 108 5e-24 4JDH-A nrPDB 108 5e-24 2Q0N-A nrPDB 108 5e-24 4EQM-A nrPDB 108 5e-24 4FIE-A nrPDB 107 6e-24 6DC0-A nrPDB 107 1e-23 4KS7-A nrPDB 106 1e-23 5CEK-A nrPDB 106 1e-23 6BXI-A nrPDB 105 3e-23 1PHK-A nrPDB 104 6e-23 3HKO-A nrPDB 104 7e-23 5LOH-A nrPDB 103 9e-23 6CQF-A nrPDB 102 2e-22 3FXW-A nrPDB 102 3e-22 3PPZ-A nrPDB 102 3e-22 4CRS-A nrPDB 102 3e-22 5TUR-A nrPDB 101 6e-22 4RC3-A nrPDB 101 6e-22 3BGP-A nrPDB 100 8e-22 4BGQ-A nrPDB 100 1e-21 1TKI-A nrPDB 100 1e-21 4OTD-A nrPDB 100 1e-21 2F57-A nrPDB 100 1e-21 3DLS-A nrPDB 100 2e-21 5VO2-A nrPDB 100 2e-21 5J5T-A nrPDB 100 2e-21 5L2Q-C nrPDB 99 2e-21 6FD3-A nrPDB 99 3e-21 3Q53-A nrPDB 98 5e-21 1U5R-A nrPDB 98 7e-21 2GCD-A nrPDB 97 8e-21 2BPM-A nrPDB 97 8e-21 2XNP-A nrPDB 97 1e-20 3C51-A nrPDB 97 1e-20 2UV2-A nrPDB 96 2e-20 3M42-A nrPDB 96 3e-20 4QMW-A nrPDB 95 4e-20 4UY9-A nrPDB 95 5e-20 2XIK-A nrPDB 95 5e-20 3GC0-A nrPDB 95 6e-20 4UYA-A nrPDB 94 6e-20 3COM-A nrPDB 94 9e-20 6GU6-A nrPDB 94 9e-20 3DTC-A nrPDB 93 2e-19 5UUU-A nrPDB 93 2e-19 4AU8-A nrPDB 93 2e-19 3PVW-A nrPDB 92 3e-19 4G3E-A nrPDB 92 5e-19 4GS6-A nrPDB 92 5e-19 4NST-A nrPDB 92 5e-19 1V0B-A nrPDB 92 5e-19 4IDT-A nrPDB 91 6e-19 6CKI-A nrPDB 91 6e-19 4AGU-A nrPDB 91 6e-19 4FR4-A nrPDB 91 7e-19 4FZF-B nrPDB 91 7e-19 3NIZ-A nrPDB 91 8e-19 4KIK-B nrPDB 91 9e-19 5KKR-C nrPDB 90 1e-18 1S9I-A nrPDB 90 1e-18 3TKU-A nrPDB 90 1e-18 4BBM-A nrPDB 90 2e-18 5AIR-A nrPDB 90 2e-18 5EFQ-A nrPDB 90 2e-18 3EQC-A nrPDB 89 2e-18 4IC8-A nrPDB 89 2e-18 3DAK-A nrPDB 89 3e-18 3QA8-A nrPDB 89 3e-18 4ZSG-A nrPDB 89 3e-18 4KRC-A nrPDB 89 3e-18 2F9G-A nrPDB 88 5e-18 6DTL-A nrPDB 88 5e-18 6HXF-B nrPDB 88 6e-18 5X5O-A nrPDB 88 6e-18 2HW6-A nrPDB 88 6e-18 6AO5-A nrPDB 87 8e-18 4LG4-A nrPDB 87 1e-17 2BUJ-A nrPDB 87 2e-17 4AN9-A nrPDB 86 2e-17 3NYO-A nrPDB 86 2e-17 4F0G-A nrPDB 85 5e-17 3ZDU-A nrPDB 85 5e-17 5DBX-A nrPDB 84 8e-17 1UA2-A nrPDB 84 1e-16 5G6V-A nrPDB 84 1e-16 5NGU-A nrPDB 84 1e-16 5Z33-A nrPDB 83 2e-16 4EWQ-A nrPDB 83 2e-16 5D7A-A nrPDB 83 2e-16 4TNB-A nrPDB 83 2e-16 4U41-A nrPDB 82 2e-16 4PWN-A nrPDB 82 3e-16 3SXS-A nrPDB 82 3e-16 4QTB-A nrPDB 82 3e-16 2WQN-A nrPDB 82 4e-16 3QGY-A nrPDB 82 5e-16 5O2C-A nrPDB 82 5e-16 5HVK-A nrPDB 82 5e-16 5O2B-A nrPDB 82 5e-16 5TQX-A nrPDB 82 5e-16 4MYG-A nrPDB 81 7e-16 3GC9-A nrPDB 81 8e-16 4E7W-A nrPDB 80 1e-15 4AW2-A nrPDB 80 1e-15 4TPT-A nrPDB 79 2e-15 1CM8-A nrPDB 79 3e-15 2VD5-A nrPDB 79 3e-15 3OMV-A nrPDB 79 3e-15 5O0Y-A nrPDB 79 3e-15 3OHT-A nrPDB 79 3e-15 4Y83-A nrPDB 79 3e-15 3ORP-A nrPDB 78 6e-15 2XS0-A nrPDB 78 6e-15 2I6L-A nrPDB 78 6e-15 6DBM-A nrPDB 77 1e-14 3E7O-A nrPDB 77 1e-14 4Y93-A nrPDB 77 1e-14 4XI2-A nrPDB 77 2e-14 2W1I-A nrPDB 77 2e-14 3E3P-A nrPDB 76 2e-14 6E4F-A nrPDB 76 2e-14 5AWM-A nrPDB 76 2e-14 2Y4I-B nrPDB 76 2e-14 6DBN-A nrPDB 76 3e-14 1ZXE-A nrPDB 75 4e-14 1G3N-A nrPDB 75 4e-14 3N9X-A nrPDB 75 4e-14 3IO7-A nrPDB 75 5e-14 3ALO-A nrPDB 74 8e-14 3VN9-A nrPDB 74 9e-14 3MIA-A nrPDB 74 9e-14 3RP9-A nrPDB 74 1e-13 4JLC-A nrPDB 74 1e-13 3FME-A nrPDB 74 1e-13 5Y86-A nrPDB 74 1e-13 4EUU-A nrPDB 73 2e-13 6NT9-A nrPDB 73 2e-13 4E20-A nrPDB 73 2e-13 4OLI-A nrPDB 73 2e-13 3FI2-A nrPDB 73 2e-13 4EUT-A nrPDB 73 2e-13 4C59-A nrPDB 73 2e-13 1JNK-A nrPDB 72 3e-13 4QNY-A nrPDB 72 4e-13 4O2Z-A nrPDB 72 5e-13 2PMN-X nrPDB 71 6e-13 2WO6-A nrPDB 71 7e-13 4YHJ-A nrPDB 71 7e-13 2Y6O-A nrPDB 71 7e-13 3HMP-A nrPDB 71 8e-13 5ZTN-A nrPDB 71 9e-13 4P5Q-A nrPDB 71 9e-13 6O8B-A nrPDB 71 9e-13 6GVJ-A nrPDB 70 1e-12 2VWV-A nrPDB 70 1e-12 2WTK-B nrPDB 70 1e-12 3NIE-A nrPDB 70 1e-12 5AP3-A nrPDB 70 1e-12 4HVI-A nrPDB 70 2e-12 6O6Q-A nrPDB 70 2e-12 5B2L-A nrPDB 70 2e-12 2W96-B nrPDB 70 2e-12 4CRL-A nrPDB 69 3e-12 3EB0-A nrPDB 69 3e-12 4YFF-A nrPDB 69 3e-12 4CSV-A nrPDB 69 4e-12 6EII-A nrPDB 69 4e-12 5HIE-A nrPDB 68 5e-12 2ZMD-A nrPDB 68 6e-12 5HI2-A nrPDB 68 6e-12 3OZ6-A nrPDB 68 6e-12 4PDO-A nrPDB 68 7e-12 4LFI-A nrPDB 68 7e-12 2R2P-A nrPDB 68 8e-12 5IKW-A nrPDB 67 8e-12 4MD7-E nrPDB 67 1e-11 5L6P-A nrPDB 67 1e-11 4LQP-A nrPDB 67 1e-11 5X8I-B nrPDB 67 1e-11 5VC6-A nrPDB 66 2e-11 4OW8-A nrPDB 66 2e-11 1JPA-A nrPDB 66 3e-11 6B2Q-A nrPDB 66 3e-11 4X3F-A nrPDB 65 3e-11 5UIU-A nrPDB 65 4e-11 1U59-A nrPDB 65 4e-11 5TE0-A nrPDB 65 6e-11 2XYN-A nrPDB 64 8e-11 3KUL-B nrPDB 64 8e-11 5H2U-A nrPDB 64 9e-11 3DKO-A nrPDB 64 1e-10 2A1A-B nrPDB 64 1e-10 1BYG-A nrPDB 64 1e-10 5XVU-A nrPDB 64 2e-10 4HZS-A nrPDB 63 2e-10 2JD5-A nrPDB 63 2e-10 1U54-B nrPDB 63 2e-10 3PLS-A nrPDB 63 2e-10 2OZO-A nrPDB 63 2e-10 4E93-A nrPDB 63 2e-10 6HMD-A nrPDB 63 2e-10 5MJB-A nrPDB 62 4e-10 5WNL-A nrPDB 61 6e-10 2PVN-A nrPDB 61 6e-10 4NEU-A nrPDB 61 7e-10 3UIU-A nrPDB 61 7e-10 1K9A-A nrPDB 60 1e-09 4AT3-A nrPDB 60 1e-09 6NPU-A nrPDB 60 1e-09 4M7I-A nrPDB 60 2e-09 4XEY-B nrPDB 59 2e-09 3A4O-X nrPDB 59 2e-09 3LLT-A nrPDB 59 3e-09 5AMN-A nrPDB 59 3e-09 3PP0-A nrPDB 59 4e-09 2RIO-A nrPDB 59 5e-09 2PSQ-A nrPDB 58 6e-09 5WNO-A nrPDB 58 6e-09 4IAN-A nrPDB 58 6e-09 2FO0-A nrPDB 58 7e-09 1AD5-A nrPDB 58 8e-09 3MDY-A nrPDB 57 9e-09 3Q4U-A nrPDB 57 9e-09 5HLW-A nrPDB 57 1e-08 5UNP-A nrPDB 57 1e-08 6CTH-A nrPDB 57 1e-08 6HV0-A nrPDB 57 1e-08 6FER-A nrPDB 57 1e-08 2HK5-A nrPDB 57 2e-08 1FVR-A nrPDB 56 2e-08 3C1X-A nrPDB 56 3e-08 1LUF-A nrPDB 56 3e-08 5U6B-A nrPDB 55 3e-08 5KMM-A nrPDB 55 3e-08 5VD3-A nrPDB 55 4e-08 3BBT-B nrPDB 55 4e-08 5E8V-A nrPDB 55 5e-08 3REP-A nrPDB 55 5e-08 4M66-A nrPDB 55 5e-08 6FEX-A nrPDB 55 6e-08 5EG3-A nrPDB 55 6e-08 2X7G-A nrPDB 55 6e-08 5AR8-A nrPDB 55 6e-08 4PL5-B nrPDB 55 6e-08 4K33-A nrPDB 54 8e-08 3RAW-A nrPDB 54 8e-08 2QKW-B nrPDB 54 9e-08 4WUA-A nrPDB 54 9e-08 3MY0-A nrPDB 54 1e-07 4XCU-A nrPDB 53 2e-07 3LMG-A nrPDB 53 3e-07 3GQL-A nrPDB 52 3e-07 2H34-A nrPDB 52 3e-07 3ZBF-A nrPDB 52 3e-07 5TOS-A nrPDB 52 4e-07 3TT0-A nrPDB 52 4e-07 5LPZ-A nrPDB 52 4e-07 5A46-A nrPDB 52 5e-07 1PY5-A nrPDB 52 5e-07 5LPV-A nrPDB 52 5e-07 3UIM-A nrPDB 52 6e-07 3PG1-A nrPDB 52 6e-07 3V5Q-A nrPDB 51 6e-07 6BSD-A nrPDB 51 1e-06 5GNK-A nrPDB 50 1e-06 5SYS-A nrPDB 50 1e-06 5VDK-A nrPDB 50 1e-06 4F9B-A nrPDB 50 1e-06 2DQ7-X nrPDB 50 2e-06 3QUP-A nrPDB 50 2e-06 2H8H-A nrPDB 50 2e-06 4NT4-A nrPDB 49 3e-06 6F3F-A nrPDB 49 3e-06 2PL0-A nrPDB 49 3e-06 3ZZW-A nrPDB 49 4e-06 5OAT-A nrPDB 49 4e-06 3LZB-A nrPDB 48 6e-06 5C26-A nrPDB 48 7e-06 2QLU-A nrPDB 47 9e-06 4BTK-A nrPDB 47 1e-05 3SOC-A nrPDB 47 1e-05 4NFN-A nrPDB 47 2e-05 4FL3-A nrPDB 47 2e-05 2C47-A nrPDB 46 2e-05 2CHL-A nrPDB 46 2e-05 5M07-A nrPDB 46 2e-05 5XD6-A nrPDB 46 3e-05 4TN6-A nrPDB 46 3e-05 2CMW-A nrPDB 45 3e-05 2PZI-A nrPDB 45 4e-05 5J0A-A nrPDB 45 4e-05 4LRM-A nrPDB 45 5e-05 4Y12-A nrPDB 45 6e-05 3SV0-A nrPDB 44 1e-04 3QD2-B nrPDB 43 2e-04 3AOX-A nrPDB 42 3e-04 4MWI-A nrPDB 42 3e-04 5X1R-A nrPDB 42 4e-04 6J5U-C nrPDB 42 4e-04 5FQD-C nrPDB 42 5e-04 1CSN-A nrPDB 42 6e-04 5CLR-A nrPDB 41 9e-04 4XHL-A nrPDB 40 0.001 6BFN-A nrPDB 40 0.002 4L00-A nrPDB 39 0.003 4XHH-A nrPDB 39 0.003 3G2F-A nrPDB 39 0.005 6EQI-C nrPDB 38 0.006 6EWX-A nrPDB 37 0.010 4JRN-A nrPDB 36 0.027 6BHC-A nrPDB 35 0.073 5UU1-A nrPDB 34 0.100 2GLJ-A nrPDB 33 0.23 5UV4-A nrPDB 32 0.33 5VE6-A nrPDB 32 0.38 2RSV-A nrPDB 31 0.80 2LAV-A nrPDB 31 0.81 6G4J-A nrPDB 31 0.88 2IRM-A nrPDB 30 1.4 5C01-A nrPDB 30 1.4 4WOV-A nrPDB 30 1.6 3G6S-A nrPDB 29 3.2 5DMZ-A nrPDB 29 3.8 4TR8-A nrPDB 28 6.2 3ICE-A nrPDB 27 10.0 >3UC3-A nrPDB Length = 361 Score = 743 bits (1918), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/361 (99%), Positives = 359/361 (99%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG ID Sbjct: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID 60 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF Sbjct: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT Sbjct: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE Sbjct: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 Query: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA 360 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA Sbjct: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA 360 Query: 361 L 361 L Sbjct: 361 L 361 >3ZUT-A nrPDB Length = 362 Score = 595 bits (1534), Expect = e-170, Method: Compositional matrix adjust. Identities = 287/363 (79%), Positives = 327/363 (90%), Gaps = 3/363 (0%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDR P +GP+D+PIMHDSDRY+ VKDIGSGNFGVARLMRDK + ELVAVKYIERG+KID Sbjct: 1 MDR-PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQL+SGVSYCH+MQ+CHRDLKLENTLLDGSPAPRLKIC FGYSKSSVLHSQPKSTVGT Sbjct: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGT 179 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 Query: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDM--DDFDSESEIDIDSSGEIV 358 QP QS++ IMQII+EAT+P + L+ ++T +LD+DDDM D ++DIDSSGEIV Sbjct: 300 QPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIV 359 Query: 359 YAL 361 YA+ Sbjct: 360 YAM 362 >5WAX-A nrPDB Length = 310 Score = 564 bits (1454), Expect = e-161, Method: Compositional matrix adjust. Identities = 260/309 (84%), Positives = 291/309 (94%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH 70 +DMPIMHD DRY+ V+DIGSGNFGVARLMR++ +LVAVKYIERG+KIDENVQREIINH Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINH 61 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 RSLRHPNI+RFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARFFFQQL+SGVS Sbjct: 62 RSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 YCHSMQ+CHRDLKLENTLLDGS APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 ++EYDGK+ADVWSCGVTLYVMLVGAYPFEDP+EP+++RKTIQRIL V+YSIPD + ISPE Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 C LISRIFVA+PATRI+IPEI+ H WFLKNLPADLM++S Q++EPEQPMQS+D IM Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDEIM 301 Query: 311 QIISEATIP 319 QI++EATIP Sbjct: 302 QILAEATIP 310 >3UDB-A nrPDB Length = 317 Score = 563 bits (1452), Expect = e-161, Method: Compositional matrix adjust. Identities = 261/318 (82%), Positives = 292/318 (91%), Gaps = 1/318 (0%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDR P GP+D+PIMHDSDRY+ VKDIG+GNFGVARLMRDK ELVAVKYIERG+KID Sbjct: 1 MDR-PAVAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID 59 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQL+SGVSY H+MQ+ HRDLKLENTLLDGSPAPRLKI DFGYSK+SVLHSQPKS VGT Sbjct: 120 FFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGT 179 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 Query: 301 QPMQSLDTIMQIISEATI 318 QP QS++ IMQII+EAT+ Sbjct: 300 QPGQSIEEIMQIIAEATV 317 >4CZT-A nrPDB Length = 464 Score = 202 bits (515), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 106/275 (38%), Positives = 160/275 (58%), Gaps = 23/275 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHP 76 +Y+ + +G G F + R+ + VA+K I++ +K+ ++REI + ++HP Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N++R EV+ + T + ++E+ +GGEL+++I + GR EDEAR +FQQL++ V YCHS Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 131 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYS-------KSSVLHSQPKSTVGTPAYIAPEVL 189 + HRDLK EN LLD + A LK+ DFG S + +LH +T GTP Y+APEV+ Sbjct: 132 VYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLH----TTCGTPNYVAPEVI 185 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + YDG AD+WSCGV L+V++ G PFED Y+K I +++ P S Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKK----IFKAEFTCPP--WFSA 239 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 LI RI +PATRI+ E+ + WF K A Sbjct: 240 SAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA 274 >3H4J-B nrPDB Length = 336 Score = 200 bits (508), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 114/266 (42%), Positives = 158/266 (59%), Gaps = 13/266 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPN 77 Y + +G G+FG +L T++ VA+K+I R + V+REI + LRHP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I++ +VI TPT + +++EYA GGEL++ I R +EDE R FFQQ++ + YCH +I Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD + +KI DFG S + K++ G+P Y APEV+ + Y G Sbjct: 130 VHRDLKPENLLLDDNL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWSCG+ LYVMLVG PF+D P ++K + S Y +PD +SP LI R Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKK----VNSCVYVMPD--FLSPGAQSLIRR 241 Query: 258 IFVADPATRISIPEIKTHSWFLKNLP 283 + VADP RI+I EI+ WF NLP Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLP 267 >4D28-A nrPDB Length = 446 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 112/277 (40%), Positives = 160/277 (57%), Gaps = 25/277 (9%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHR 71 M +Y+ + IG G F + R+ T + VA+K + + +++ + ++REI + Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 +RHPNIVR EV+ + + + I++E+ +GGEL++RI + GR EDE+R +FQQL+ V++ Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-------TVGTPAYI 184 CHS + HRDLK EN LLD + LK+ DFG L + P+ T GTP Y+ Sbjct: 125 CHSKGVYHRDLKPENLLLDTN--GNLKVSDFG------LSALPQEGVELLNDTCGTPNYV 176 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 APEVL Q YDG AD+WSCGV L+V+L G PF + + P YRK I + ++ P Sbjct: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFDCPP- 231 Query: 245 IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 S E LI RI +P TRI I IK WF KN Sbjct: 232 -WFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKN 267 >4RED-A nrPDB Length = 351 Score = 193 bits (491), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 113/327 (34%), Positives = 169/327 (51%), Gaps = 19/327 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPNIVRFKE 83 +G G FG ++ + +LT VAVK + R + ++REI N + RHP+I++ + Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 VI TP+ + ++MEY SGGEL++ IC GR E E+R FQQ+LSGV YCH + HRDLK Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 141 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD KI DFG S +++ G+P Y APEV+ + Y G D+WS Sbjct: 142 PENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 GV LY +L G PF+D P ++K I + P ++P L+ + DP Sbjct: 200 SGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQ--YLNPSVISLLKHMLQVDP 253 Query: 264 ATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRN 323 R SI +I+ H WF ++LP L E + S ++ ++ + + E + + N Sbjct: 254 MKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEVLSCLYN 313 Query: 324 RCLDD-------FMTDNLDLDDDMDDF 343 R D + DN + ++ DF Sbjct: 314 RNHQDPLAVAYHLIIDNRRIMNEAKDF 340 >4REW-A nrPDB Length = 540 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 113/327 (34%), Positives = 169/327 (51%), Gaps = 19/327 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPNIVRFKE 83 +G G FG ++ + +LT VAVK + R + ++REI N + RHP+I++ + Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 VI TP+ + ++MEY SGGEL++ IC GR E E+R FQQ+LSGV YCH + HRDLK Sbjct: 74 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLK 133 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD KI DFG S +++ G+P Y APEV+ + Y G D+WS Sbjct: 134 PENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 191 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 GV LY +L G PF+D P ++K I + P ++P L+ + DP Sbjct: 192 SGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQ--YLNPSVISLLKHMLQVDP 245 Query: 264 ATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRN 323 R SI +I+ H WF ++LP L E + S ++ ++ + + E + + N Sbjct: 246 MKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYN 305 Query: 324 RCLDD-------FMTDNLDLDDDMDDF 343 R D + DN + ++ DF Sbjct: 306 RNHQDPLAVAYHLIIDNRRIMNEAKDF 332 >4CFH-A nrPDB Length = 493 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 117/350 (33%), Positives = 175/350 (50%), Gaps = 23/350 (6%) Query: 9 GPLDMPIMHDS----DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KID 60 GP+ HD Y +G G FG ++ + +LT VAVK + R + Sbjct: 18 GPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV 77 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ++REI N + RHP+I++ +VI TP+ + ++MEY SGGEL++ IC GR E E+R Sbjct: 78 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRR 137 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FQQ+LSGV YCH + HRDLK EN LLD KI DFG S +++ G+ Sbjct: 138 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGS 195 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 P Y APEV+ + Y G D+WS GV LY +L G PF+D P ++K I + Sbjct: 196 PNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FY 251 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 P ++P L+ + DP R +I +I+ H WF ++LP L E + S + Sbjct: 252 TPQ--YLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDD 309 Query: 301 QPMQSLDTIMQIISEATIPAVRNRCLDD-------FMTDNLDLDDDMDDF 343 + ++ + + E + + NR D + DN + ++ DF Sbjct: 310 EALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 359 >4CFF-A nrPDB Length = 571 Score = 192 bits (488), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 111/289 (38%), Positives = 153/289 (52%), Gaps = 16/289 (5%) Query: 9 GPLDMPIMHDS----DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KID 60 GP+ HD Y +G G FG ++ +LT VAVK + R + Sbjct: 18 GPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV 77 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ++REI N + RHP+I++ +VI TPT ++MEY SGGEL++ IC GR E EAR Sbjct: 78 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 137 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FQQ+LS V YCH + HRDLK EN LLD KI DFG S +++ G+ Sbjct: 138 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGS 195 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 P Y APEV+ + Y G D+WSCGV LY +L G PF+D P ++K I + Sbjct: 196 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFY 251 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 IP+ + S L+ + DP R +I +I+ H WF ++LP+ L E Sbjct: 252 IPEYLNRS--VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 298 >5EZV-A nrPDB Length = 560 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 106/266 (39%), Positives = 147/266 (55%), Gaps = 12/266 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPNIVRFKE 83 +G G FG ++ +LT VAVK + R + ++REI N + RHP+I++ + Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH + HRDLK Sbjct: 96 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 155 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD KI DFG S +++ G+P Y APEV+ + Y G D+WS Sbjct: 156 PENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 213 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 CGV LY +L G PF+D P ++K I + IP+ + S L+ + DP Sbjct: 214 CGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLMHMLQVDP 267 Query: 264 ATRISIPEIKTHSWFLKNLPADLMNE 289 R +I +I+ H WF ++LP+ L E Sbjct: 268 LKRATIKDIREHEWFKQDLPSYLFPE 293 >2YZA-A nrPDB Length = 276 Score = 189 bits (480), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 106/266 (39%), Positives = 146/266 (54%), Gaps = 12/266 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPNIVRFKE 83 +G G FG ++ +LT VAVK + R + ++REI N + RHP+I++ + Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH + HRDLK Sbjct: 79 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 138 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD KI DFG S + + G+P Y APEV+ + Y G D+WS Sbjct: 139 PENVLLDAHMNA--KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIWS 196 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 CGV LY +L G PF+D P ++K I + IP+ + S L+ + DP Sbjct: 197 CGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLMHMLQVDP 250 Query: 264 ATRISIPEIKTHSWFLKNLPADLMNE 289 R +I +I+ H WF ++LP+ L E Sbjct: 251 LKRATIKDIREHEWFKQDLPSYLFPE 276 >2QNJ-A nrPDB Length = 328 Score = 187 bits (476), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 110/282 (39%), Positives = 157/282 (55%), Gaps = 17/282 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNI 78 Y +K IG GNF +L R LT VA+K I++ ++Q RE+ + L HPNI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V+ EVI T L +IMEYASGGE+++ + GR E EAR F+Q++S V YCH +I Sbjct: 74 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 133 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLD +KI DFG+S + + + G+P Y APE+ ++YDG Sbjct: 134 HRDLKAENLLLDAD--MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPE 191 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS GV LY ++ G+ PF D + ++ R +R+L KY IP +S +C +L+ R Sbjct: 192 VDVWSLGVILYTLVSGSLPF-DGQNLKELR---ERVLRGKYRIP--FYMSTDCENLLKRF 245 Query: 259 FVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 V +P R ++ +I W + +E + F EPE Sbjct: 246 LVLNPIKRGTLEQIMKDRWI------NAGHEEDELKPFVEPE 281 >5ES1-A nrPDB Length = 328 Score = 186 bits (473), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 104/283 (36%), Positives = 156/283 (55%), Gaps = 17/283 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNI 78 Y ++ IG GNF +L R LT VA+K I++ ++Q RE+ + L HPNI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V+ EVI T L ++MEYAS GE+++ + + GR E EAR F+Q++S V YCH I Sbjct: 77 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV 136 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLD +KI DFG+S L S+ + G+P Y APE+ ++YDG Sbjct: 137 HRDLKAENLLLDAE--ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 D+WS GV LY ++ G+ PF+ + ++ +R+L KY +P +S +C ++ R Sbjct: 195 VDIWSLGVILYTLVSGSLPFDG----HNLKELRERVLRGKYRVP--FYMSTDCESILRRF 248 Query: 259 FVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 V +PA R ++ +I W ++ E + EPE+ Sbjct: 249 LVLNPAKRCTLEQIMKDKWI------NIGYEGEELKPYTEPEE 285 >5KZ7-A nrPDB Length = 346 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 103/259 (39%), Positives = 150/259 (57%), Gaps = 11/259 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNI 78 Y +K IG GNF +L R LT + VAVK I++ ++Q RE+ + L HPNI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 95 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV 154 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLD +KI DFG+S ++ + G+P Y APE+ ++YDG Sbjct: 155 HRDLKAENLLLDAD--MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPE 212 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS GV LY ++ G+ PF D + ++ R +R+L KY IP +S +C +L+ + Sbjct: 213 VDVWSLGVILYTLVSGSLPF-DGQNLKELR---ERVLRGKYRIP--FYMSTDCENLLKKF 266 Query: 259 FVADPATRISIPEIKTHSW 277 + +P+ R ++ +I W Sbjct: 267 LILNPSKRGTLEQIMKDRW 285 >4YNZ-A nrPDB Length = 342 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 100/286 (34%), Positives = 164/286 (57%), Gaps = 25/286 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV----QREIINHRSLRHPN 77 Y K +G G G+ +L +T + VA+K + R +K+ E+V +REI + + HP+ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNR-EKLSESVLMKVEREIAILKLIEHPH 70 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +++ +V +L +++E+ SGGEL++ + GR + EAR FF+Q++S + +CHS I Sbjct: 71 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 CHRDLK EN LLD ++I DFG + V S +++ G+P Y PEV+ ++YDG+ Sbjct: 131 CHRDLKPENLLLD--ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 ADVWSCGV L+ +LVGA PF+D + R+ ++++ + +P I P+C L+ Sbjct: 189 KADVWSCGVILFALLVGALPFDDD----NLRQLLEKVKRGVFHMPH--FIPPDCQSLLRG 242 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPM 303 + D A R+++ I+ H W++ G EPEQP+ Sbjct: 243 MIEVDAARRLTLEHIQKHIWYI------------GGKNEPEPEQPI 276 >3MN3-A nrPDB Length = 271 Score = 181 bits (460), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 107/270 (39%), Positives = 150/270 (55%), Gaps = 13/270 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLRHPN 77 Y VK +G G+FG +L T + VA+K I + + ++REI R LRHP+ Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I++ +VI + + +++EYA G EL++ I + SE EAR FFQQ++S V YCH +I Sbjct: 66 IIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKI 124 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD +KI DFG S + K++ G+P Y APEV+ + Y G Sbjct: 125 VHRDLKPENLLLD--EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGP 182 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWSCGV LYVML PF+D P ++ + Y++P +SP LI R Sbjct: 183 EVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGV----YTLPK--FLSPGAAGLIKR 236 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLM 287 + + +P RISI EI WF +LP L+ Sbjct: 237 MLIVNPLNRISIHEIMQDDWFKVDLPEYLL 266 >2HAK-A nrPDB Length = 328 Score = 178 bits (452), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 150/259 (57%), Gaps = 11/259 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNI 78 Y K IG GNF +L R LT VAVK I++ ++Q RE+ + L HPNI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 77 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 136 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLDG +KI DFG+S + ++ + G+P Y APE+ ++YDG Sbjct: 137 HRDLKAENLLLDGD--MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS GV LY ++ G+ PF D + ++ R +R+L KY IP +S +C +L+ ++ Sbjct: 195 VDVWSLGVILYTLVSGSLPF-DGQNLKELR---ERVLRGKYRIP--FYMSTDCENLLKKL 248 Query: 259 FVADPATRISIPEIKTHSW 277 V +P R S+ +I W Sbjct: 249 LVLNPIKRGSLEQIMKDRW 267 >6C9D-A nrPDB Length = 459 Score = 177 bits (450), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 106/259 (40%), Positives = 149/259 (57%), Gaps = 11/259 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNI 78 Y K IG GNF +L R LT VAVK I++ ++Q RE+ + L HPNI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 83 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 142 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLDG +KI DFG+S + ++ G+P Y APE+ ++YDG Sbjct: 143 HRDLKAENLLLDGD--MNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPE 200 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS GV LY ++ G+ PF D + ++ R +R+L KY IP +S +C +L+ ++ Sbjct: 201 VDVWSLGVILYTLVSGSLPF-DGQNLKELR---ERVLRGKYRIP--FYMSTDCENLLKKL 254 Query: 259 FVADPATRISIPEIKTHSW 277 V +P R S+ +I W Sbjct: 255 LVLNPIKRGSLEQIMKDRW 273 >5YKS-A nrPDB Length = 377 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 96/262 (36%), Positives = 150/262 (57%), Gaps = 13/262 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRHPN 77 YD K +G G+F V +L R T E VAVK I++ K+D ++ +E+ + ++HPN Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK-TKLDTLATGHLFQEVRCMKLVQHPN 95 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQ 136 IVR EVI T T L +I+E GG++++ I +ED A+ +F Q++ +SYCH + Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK EN + +K+ DFG+S + ++ G+ AY APE+LL EYD Sbjct: 156 VVHRDLKPENVVFFEKQG-LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+WS GV L++++ G PF++ + +T+ I+ KY++P +S EC LI+ Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDS----ETLTMIMDCKYTVPS--HVSKECKDLIT 268 Query: 257 RIFVADPATRISIPEIKTHSWF 278 R+ DP R S+ EI+ H W Sbjct: 269 RMLQRDPKRRASLEEIENHPWL 290 >3HZT-A nrPDB Length = 467 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 107/302 (35%), Positives = 159/302 (52%), Gaps = 21/302 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLR 74 SDRY VK +GSG +G L +DKLT A+K I++ + +++ + L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNI++ E + ++ME GGEL++ I +FSE +A +Q+LSG +Y H Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 135 MQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 I HRDLK EN LL+ L KI DFG S + + K +GT YIAPEV LR++ Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV-LRKK 181 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 YD K DVWSCGV LY++L G PF + ++ ++R+ K+S PD ++S E Sbjct: 182 YDEK-CDVWSCGVILYILLCGYPPFGGQTD----QEILKRVEKGKFSFDPPDWTQVSDEA 236 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFLK---NLPADLMNESNTGS-----QFQEPEQPM 303 L+ + +P+ RIS E H W +K D+ + TG+ +FQ ++ Sbjct: 237 KQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQSSQKLA 296 Query: 304 QS 305 Q+ Sbjct: 297 QA 298 >3DXN-A nrPDB Length = 287 Score = 164 bits (414), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 102/281 (36%), Positives = 151/281 (53%), Gaps = 13/281 (4%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQRE 66 ++G ++ SDRY VK +GSG +G L +DKLT A+K I++ + Sbjct: 8 SSGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGA 67 Query: 67 IINH----RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFF 122 +++ + L HPNI++ E + ++ME GGEL++ I +FSE +A Sbjct: 68 LLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIM 127 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTP 181 +Q+LSG +Y H I HRDLK EN LL+ L KI DFG S + + K +GT Sbjct: 128 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTA 187 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 YIAPEV LR++YD K DVWSCGV LY++L G PF + ++ ++R+ K+S Sbjct: 188 YYIAPEV-LRKKYDEK-CDVWSCGVILYILLCGYPPFGGQTD----QEILKRVEKGKFSF 241 Query: 242 --PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 PD ++S E L+ + +P+ RIS E H W +K Sbjct: 242 DPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >2J90-A nrPDB Length = 304 Score = 160 bits (406), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 94/269 (34%), Positives = 144/269 (53%), Gaps = 16/269 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-------RGDKIDENVQREIINHRS 72 D Y+ +++GSG F + R R K T + A K+I+ R E ++RE+ R Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 +RHPNI+ ++ T + +I+E SGGEL++ + +EDEA F +Q+L GV Y Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 133 HSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS +I H DLK EN +L P PR+K+ DFG + ++ K+ GTP ++APE+ + Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEI-V 204 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RIS 248 E G AD+WS GV Y++L GA PF + ++T+ I +V Y ++ S Sbjct: 205 NYEPLGLEADMWSIGVITYILLSGASPFLGETK----QETLTNISAVNYDFDEEYFSNTS 260 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 I R+ V DP R++I + HSW Sbjct: 261 ELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 >4CQG-A nrPDB Length = 331 Score = 160 bits (405), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 98/281 (34%), Positives = 151/281 (53%), Gaps = 24/281 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPNIV 79 Y+ + IG+G F +L LT E+VA+K +++ + V+ EI +SLRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ T + +++EY GGEL++ I + R SE+E R F+Q+LS V+Y HS H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAH 130 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--------VGTPAYIAPEVLLR 191 RDLK EN L D + +LK+ DFG L ++PK G+ AY APE++ Sbjct: 131 RDLKPENLLFDEN--HKLKLIDFG------LCAKPKGNKDYHLQECCGSLAYAAPELIQG 182 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 + Y G ADVWS G+ LYV++ G PF+D Y+K I+ KY +P +SP Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKK----IMRGKYEVPK--WLSPSS 236 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNT 292 L+ ++ DP RIS+ + H W +++ + +S T Sbjct: 237 ILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKT 277 >2BRG-A nrPDB Length = 297 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 97/281 (34%), Positives = 155/281 (55%), Gaps = 21/281 (7%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREII 68 + +P + D +D V+ +G G +G +L +++T+E VAVK ++ +D EN+++EI Sbjct: 1 MAVPFVED---WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEIC 57 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 ++ L H N+V+F + +EY SGGEL++RI E +A+ FF QL++G Sbjct: 58 INKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIA 185 V Y H + I HRD+K EN LLD LKI DFG + +++ + GT Y+A Sbjct: 118 VVYLHGIGITHRDIKPENLLLDER--DNLKISDFGLATVFRYNNRERLLNKMCGTLPYVA 175 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDP----EEPRDYRKTIQRILSVKYSI 241 PE+L R+E+ + DVWSCG+ L ML G P++ P +E D+++ + K Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWK--- 232 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 +I L+ +I V +P+ RI+IP+IK W+ K L Sbjct: 233 ----KIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 269 >3GUB-A nrPDB Length = 295 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 93/269 (34%), Positives = 145/269 (53%), Gaps = 16/269 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-------RGDKIDENVQREIINHRS 72 D YD +++GSG F V + R+K T A K+I+ R E+++RE+ + Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 ++HPN++ EV T + +I E +GGEL++ + +E+EA F +Q+L+GV Y Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 133 HSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS+QI H DLK EN +L P PR+KI DFG + ++ K+ GTP ++APE+ + Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEI-V 189 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RIS 248 E G AD+WS GV Y++L GA PF + ++T+ + +V Y D+ S Sbjct: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANVSAVNYEFEDEYFSNTS 245 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 I R+ V DP R++I + H W Sbjct: 246 ALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274 >3NCG-A nrPDB Length = 486 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 96/268 (35%), Positives = 145/268 (54%), Gaps = 12/268 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG---DKIDENVQREIINHRSLRH 75 ++RY+ V +G G+FG +D++T++ AVK I + +K + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI++ E++ + I+ E +GGEL++ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 136 QICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEV LR Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEV-LRGTY 199 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS--IPDDIRISPECC 252 D K DVWS GV LY++L G PF E ++R+ + KY+ +P IS + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNE----YDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK 280 LI ++ P+ RI+ + H W K Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQK 282 >4D2V-A nrPDB Length = 356 Score = 155 bits (391), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 93/281 (33%), Positives = 150/281 (53%), Gaps = 26/281 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPNIV 79 Y+ + IG+G F +L LT E+VA+K +++ + ++ EI ++LRH +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ T + +++EY GGEL++ I + R SE+E R F+Q++S V+Y HS H Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK--------STVGTPAYIAPEVLLR 191 RDLK EN L D +LK+ DFG L ++PK + G AY APE++ Sbjct: 151 RDLKPENLLFD--EYHKLKLIDFG------LCAKPKGNKDYHLQACCGALAYAAPELIQG 202 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 + Y G ADVWS G+ LYV++ G PF+D + +I+ KY +P +SP Sbjct: 203 KSYLGSEADVWSMGILLYVLMCGFLPFDDDTAA----ALVAKIMRGKYDVPK--WLSPSS 256 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFLK--NLPADLMNES 290 L+ ++ DP RIS+ + H W ++ N P + +++ Sbjct: 257 ILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKN 297 >5JN2-A nrPDB Length = 525 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 104/290 (35%), Positives = 150/290 (51%), Gaps = 20/290 (6%) Query: 4 APVTTGPLD-------MPIMHD----SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKY 52 A + GP D M + H SDRY + +G G+FG L +DK+T + AVK Sbjct: 40 AGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV 99 Query: 53 IER---GDKID-ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC 108 I + K D E++ RE+ + L HPNI++ E + ++ E +GGEL++ I Sbjct: 100 ISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEII 159 Query: 109 NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKS 167 + RFSE +A +Q+LSG++Y H +I HRDLK EN LL+ S ++I DFG S Sbjct: 160 SRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTH 219 Query: 168 SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 + K +GT YIAPEV L YD K DVWS GV LY++L G PF E D Sbjct: 220 FEASKKMKDKIGTAYYIAPEV-LHGTYDEK-CDVWSTGVILYILLSGCPPFNGANE-YDI 276 Query: 228 RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSW 277 K +++ + +P ++S LI ++ P+ RIS + H W Sbjct: 277 LKKVEKG-KYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEW 325 >3DFA-A nrPDB Length = 286 Score = 153 bits (386), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 96/268 (35%), Positives = 145/268 (54%), Gaps = 12/268 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG---DKIDENVQREIINHRSLRH 75 ++RY+ V +G G+FG +D++T++ AVK I + +K + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI++ E++ + I+ E +GGEL++ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 136 QICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEV LR Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEV-LRGTY 199 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS--IPDDIRISPECC 252 D K DVWS GV LY++L G PF E ++R+ + KY+ +P IS + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNE----YDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK 280 LI ++ P+ RI+ + H W K Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQK 282 >3MA6-A nrPDB Length = 298 Score = 150 bits (380), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 98/264 (37%), Positives = 142/264 (53%), Gaps = 9/264 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKID-ENVQREIINHRSLR 74 SDRY + +G G+FG L +DK+T + AVK I + K D E++ RE+ + L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 90 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNI++ E + ++ E +GGEL++ I + RFSE +A +Q+LSG++Y H Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 150 Query: 135 MQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 +I HRDLK EN LL+ S ++I DFG S + K +GT YIAPEV L Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV-LHGT 209 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 YD K DVWS GV LY++L G PF E D K +++ + +P ++S Sbjct: 210 YDEK-CDVWSTGVILYILLSGCPPFNGANE-YDILKKVEK-GKYTFELPQWKKVSESAKD 266 Query: 254 LISRIFVADPATRISIPEIKTHSW 277 LI ++ P+ RIS + H W Sbjct: 267 LIRKMLTYVPSMRISARDALDHEW 290 >5FG8-A nrPDB Length = 285 Score = 150 bits (379), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 91/267 (34%), Positives = 138/267 (51%), Gaps = 8/267 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRH 75 SD YD +++G G F + + K T A K I + Q RE R L H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I + ++ + +GGEL+E I +SE +A QQ+L V++CH Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYS-KSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 + HRDLK EN LL + +K+ DFG + + H GTP Y++PEVL ++ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y GK D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE + Sbjct: 193 Y-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI--KAGAYDYPSPEWDTVTPEAKN 249 Query: 254 LISRIFVADPATRISIPEIKTHSWFLK 280 LI+++ +P RI+ E H W + Sbjct: 250 LINQMLTVNPNKRITAAEALKHPWICQ 276 >2JAM-A nrPDB Length = 304 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 90/258 (34%), Positives = 139/258 (53%), Gaps = 10/258 (3%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSLRHPNIVRFK 82 F++ +GSG F L++ +LT +L A+K I++ D +++ EI + ++H NIV + Sbjct: 13 FMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLE 72 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 ++ + TH ++M+ SGGEL++RI G ++E +A QQ+LS V Y H I HRDL Sbjct: 73 DIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 132 Query: 143 KLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADV 201 K EN L L ++ I DFG SK + + GTP Y+APEVL ++ Y K D Sbjct: 133 KPENLLYLTPEENSKIMITDFGLSKME-QNGIMSTACGTPGYVAPEVLAQKPYS-KAVDC 190 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE--CCHLISRIF 259 WS GV Y++L G PF + E + + K + + DDI S + CHL+ + Sbjct: 191 WSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK-- 248 Query: 260 VADPATRISIPEIKTHSW 277 DP R + + +H W Sbjct: 249 --DPNERYTCEKALSHPW 264 >3F3Z-A nrPDB Length = 277 Score = 149 bits (375), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 93/271 (34%), Positives = 140/271 (51%), Gaps = 10/271 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPNIVR 80 Y IG G++G ++ K T+ A K I + D + ++EI +SL HPNI+R Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIR 70 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 E T + ++ME +GGEL+ER+ + F E +A + +LS V+YCH + + HR Sbjct: 71 LYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHR 130 Query: 141 DLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIA 199 DLK EN L L SP LK+ DFG + ++ VGTP Y++P+VL + G Sbjct: 131 DLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL--EGLYGPEC 188 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP--DDIRISPECCHLISR 257 D WS GV +YV+L G PF P + + + +I ++ P D + +SP+ LI R Sbjct: 189 DEWSAGVMMYVLLCGYPPFSAPTD----SEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMN 288 + P RI+ + H WF K L + N Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQLSSSPRN 275 >5U6Y-A nrPDB Length = 461 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 135/263 (51%), Gaps = 12/263 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREIINHRSLRHPNI 78 Y +++G G F V R L + A K I + + ++RE R L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 VR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M + Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 139 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQEYDG 196 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Y G Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 180 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHL 254 K D+W+CGV LY++LVG PF D ++ R Y Q+I + Y P+ ++PE L Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLY----QQIKAGAYDFPSPEWDTVTPEAKDL 236 Query: 255 ISRIFVADPATRISIPEIKTHSW 277 I+++ +P+ RI+ E H W Sbjct: 237 INKMLTINPSKRITAAEALKHPW 259 >2VZ6-A nrPDB Length = 313 Score = 148 bits (374), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 136/263 (51%), Gaps = 12/263 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHPNI 78 Y +++G G F V R L + A K I + + + ++RE R L+HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 VR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M + Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 143 Query: 139 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQEYDG 196 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Y G Sbjct: 144 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 202 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHL 254 K D+W+CGV LY++LVG PF D ++ R Y Q+I + Y P+ ++PE L Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLY----QQIKAGAYDFPSPEWDTVTPEAKDL 258 Query: 255 ISRIFVADPATRISIPEIKTHSW 277 I+++ +P+ RI+ E H W Sbjct: 259 INKMLTINPSKRITAAEALKHPW 281 >2W4O-A nrPDB Length = 349 Score = 148 bits (374), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 97/285 (34%), Positives = 151/285 (52%), Gaps = 13/285 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR-EIINHRSLRHPN 77 SD ++ ++G G + + K T++ A+K +++ +D+ + R EI L HPN Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKK--TVDKKIVRTEIGVLLRLSHPN 109 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I++ KE+ TPT +++++E +GGEL++RI G +SE +A +Q+L V+Y H I Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 138 CHRDLKLENTLLDGSPAPR--LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 HRDLK EN LL +PAP LKI DFG SK K+ GTP Y APE+L Y Sbjct: 170 VHRDLKPEN-LLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY- 227 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCH 253 G D+WS G+ Y++L G PF D R + +RIL+ +Y P +S Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYD---ERGDQFMFRRILNCEYYFISPWWDEVSLNAKD 284 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 L+ ++ V DP R++ + H W + A+ ++ + QE Sbjct: 285 LVRKLIVLDPKKRLTTFQALQHPW-VTGKAANFVHMDTAQKKLQE 328 >3BHH-A nrPDB Length = 295 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 97/282 (34%), Positives = 142/282 (50%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 +D Y +DIG G F V R T A K I + + + ++RE R L+H Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 NIVR + I ++ + +GGEL+E I +SE +A QQ+L V +CH M Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 + HRDLK EN LL +K+ DFG + Q GTP Y++PEVL ++ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D D K Q+I + Y P+ ++PE Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWD----EDQHKLYQQIKAGAYDFPSPEWDTVTPEA 237 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 +LI+++ +PA RI+ E H W ++ A +M+ T Sbjct: 238 KNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQET 279 >2VN9-A nrPDB Length = 301 Score = 147 bits (372), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 97/282 (34%), Positives = 145/282 (51%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 +D Y +++G G F V R T + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I ++ + +GGEL+E I +SE +A QQ+L V++CH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 I HRDLK EN LL S +K+ DFG + Q GTP Y++PEVL + Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D ++ R Y Q+I + Y P+ ++PE Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLY----QQIKAGAYDFPSPEWDTVTPEA 237 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 LI+++ +PA RI+ E H W ++ A +M+ T Sbjct: 238 KDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQET 279 >6CMJ-A nrPDB Length = 321 Score = 147 bits (371), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 100/284 (35%), Positives = 145/284 (51%), Gaps = 34/284 (11%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID------------ENVQREI 67 D+Y +IG G++GV +L ++ A+K + + I E V +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 68 INHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 + L HPN+V+ EV+ P HL ++ E + G + E + SED+ARF+FQ L Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDL 152 Query: 126 LSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSK----SSVLHSQPKSTVG 179 + G+ Y H +I HRD+K N L+ DG +KI DFG S S L S +TVG Sbjct: 153 IKGIEYLHYQKIIHRDIKPSNLLVGEDG----HIKIADFGVSNEFKGSDALLS---NTVG 205 Query: 180 TPAYIAPEVL--LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 TPA++APE L R+ + GK DVW+ GVTLY + G PF D +I S Sbjct: 206 TPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERIMCLHSKIKSQ 261 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 PD I+ + LI+R+ +P +RI +PEIK H W ++ Sbjct: 262 ALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >4FG9-A nrPDB Length = 320 Score = 146 bits (368), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 97/273 (35%), Positives = 137/273 (50%), Gaps = 14/273 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D YDF +G+G F L DK T++LVA+K I E + + +++ EI ++HPN Sbjct: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPN 77 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV ++ + HL +IM+ SGGEL++RI G ++E +A Q+L V Y H + I Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 138 CHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 HRDLK EN L LD ++ I DFG SK S + GTP Y+APEVL ++ Y Sbjct: 138 VHRDLKPENLLYYSLDED--SKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPY 195 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECC 252 K D WS GV Y++L G PF D + K ++IL +Y P IS Sbjct: 196 -SKAVDCWSIGVIAYILLCGYPPFYDENDA----KLFEQILKAEYEFDSPYWDDISDSAK 250 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLKNLPAD 285 I + DP R + + H W + D Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD 283 >2JC6-A nrPDB Length = 334 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 89/261 (34%), Positives = 132/261 (50%), Gaps = 10/261 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG--DKIDENVQREIINHRSLRHPNIV 79 ++F + +G+G F L +K T +L AVK I + + +++ EI R ++H NIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 +++ +P HL ++M+ SGGEL++RI G ++E +A +Q+L V Y H M I H Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 143 Query: 140 RDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 RDLK EN L ++ I DFG SK + GTP Y+APEVL ++ Y K Sbjct: 144 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKA 202 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHLIS 256 D WS GV Y++L G PF D + K ++IL +Y P IS I Sbjct: 203 VDCWSIGVIAYILLCGYPPFYDENDS----KLFEQILKAEYEFDSPYWDDISDSAKDFIR 258 Query: 257 RIFVADPATRISIPEIKTHSW 277 + DP R + + H W Sbjct: 259 NLMEKDPNKRYTCEQAARHPW 279 >5IG1-A nrPDB Length = 344 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 99/320 (30%), Positives = 159/320 (49%), Gaps = 26/320 (8%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE----RGDKIDENVQREIINHR 71 ++D D D IG G F +K T E+ AVK I R +I++ ++REI Sbjct: 13 LYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINK-IKREIGICS 71 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 SL+H +IV + +H ++ EY SGGEL++ I ++E +A Q+LS + + Sbjct: 72 SLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQH 131 Query: 132 CHSMQICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEV 188 CHS I HRDLK EN LL P +KI DFG + ++ P GTP Y++PEV Sbjct: 132 CHSKNIIHRDLKPENLLLASKDPNAPVKITDFGL--AVIMEQGPTYFGFAGTPGYLSPEV 189 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--R 246 + R YD + DVW+CGV LY++LVG PF + D++K +I + +Y P Sbjct: 190 IRRVPYDTAV-DVWACGVILYILLVGYPPFWE----EDHQKLYAQIKNCQYDFPSPEWDS 244 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNES--------NTGSQFQ 297 ++ LI + +P R ++ E+ H W +++P + ++ N + + Sbjct: 245 VTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSVHRQATLEELKKFNARRKLK 304 Query: 298 EPEQPMQSLDTIMQIISEAT 317 + + +M+ + EAT Sbjct: 305 GGVNAVIGVSKMMRTMQEAT 324 >3SOA-A nrPDB Length = 444 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 91/266 (34%), Positives = 137/266 (51%), Gaps = 12/266 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 ++ Y +++G G F V R L + A I + + + ++RE R L+H Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 + HR+LK EN LL +K+ DFG + Q GTP Y++PEVL + Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D ++ R Y Q+I + Y P+ ++PE Sbjct: 190 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLY----QQIKAGAYDFPSPEWDTVTPEA 244 Query: 252 CHLISRIFVADPATRISIPEIKTHSW 277 LI+++ +P+ RI+ E H W Sbjct: 245 KDLINKMLTINPSKRITAAEALKHPW 270 >3D2K-A nrPDB Length = 272 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 91/277 (32%), Positives = 147/277 (53%), Gaps = 14/277 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQ 64 GPL + +D + +G G FG L R++ +K ++A+K + + ++ ++ Sbjct: 1 GPLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR 60 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 RE+ LRHPNI+R T + +I+EYA G +Y + RF E + + Sbjct: 61 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITE 120 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 L + +SYCHS ++ HRD+K EN LL GS LKI DFG+S + S+ + GT Y+ Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLL-GSNG-ELKIADFGWSVHAP-SSRRTTLCGTLDYL 177 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 PE++ + +D K+ D+WS GV Y LVG PF E Y++T +RI V+++ PD Sbjct: 178 PPEMIEGRMHDEKV-DLWSLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDF 232 Query: 245 IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 ++ LISR+ + + R+++ E+ H W N Sbjct: 233 --VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKAN 267 >4UZD-A nrPDB Length = 287 Score = 144 bits (364), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 91/282 (32%), Positives = 151/282 (53%), Gaps = 16/282 (5%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPN 77 ++ + +G G FG L R+K +K ++A+K + + ++ ++RE+ LRHPN Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I+R T + +I+EYA G +Y + +F E + +L + +SYCHS ++ Sbjct: 70 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 129 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRD+K EN LL GS A LKI DFG+S + S+ + GT Y+ PE++ + +D K Sbjct: 130 IHRDIKPENLLL-GS-AGELKIADFGWSVHAP-SSRRTTLCGTLDYLPPEMIEGRMHDEK 186 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 + D+WS GV Y LVG PF E Y++T +RI V+++ PD ++ LISR Sbjct: 187 V-DLWSLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDF--VTEGARDLISR 239 Query: 258 IFVADPATRISIPEIKTHSWFLKN--LPADLMNESNTGSQFQ 297 + +P+ R + E+ H W N P++ N+ + + + Sbjct: 240 LLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAAAALE 281 >3LIJ-A nrPDB Length = 494 Score = 144 bits (363), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 94/267 (35%), Positives = 140/267 (52%), Gaps = 12/267 (4%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSL 73 H S+ Y VK +GSG +G L RDK+T A+K I + + + E+ + L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 HPNI++ + + ++ME GGEL++ I + +F+E +A +Q+LSGV+Y H Sbjct: 94 DHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 134 SMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 I HRDLK EN LL+ L KI DFG S + K +GT YIAPEV LR+ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEV-LRK 212 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPE 250 +YD K DVWS GV L+++L G PF + ++ ++++ KY+ P+ +S Sbjct: 213 KYDEK-CDVWSIGVILFILLAGYPPFGGQTD----QEILRKVEKGKYTFDSPEWKNVSEG 267 Query: 251 CCHLISRIFVADPATRISIPEIKTHSW 277 LI ++ D RIS + H W Sbjct: 268 AKDLIKQMLQFDSQRRISAQQALEHPW 294 >2YAB-A nrPDB Length = 361 Score = 144 bits (363), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 89/269 (33%), Positives = 141/269 (52%), Gaps = 16/269 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-------RGDKIDENVQREIINHRS 72 D YD +++GSG F + + R+K T A K+I+ R E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ 71 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 + HPNI+ +V T + +I+E SGGEL++ + SE+EA F +Q+L GV+Y Sbjct: 72 VLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 133 HSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 H+ +I H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RIS 248 E G AD+WS GV Y++L GA PF + ++T+ I +V Y ++ + S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSYDFDEEFFSQTS 246 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 I ++ V + R++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >2BDW-A nrPDB Length = 362 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 90/264 (34%), Positives = 134/264 (50%), Gaps = 9/264 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 SD YD +++G G F V R K T A K I K+ + ++RE R L+ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINT-KKLSARDFQKLEREARICRKLQ 86 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNIVR + I + ++ + +GGEL+E I +SE +A QQ+L ++YCHS Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS 146 Query: 135 MQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 I HR+LK EN LL + +K+ DFG + GTP Y++PEVL + Sbjct: 147 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDP 206 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y K D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE Sbjct: 207 YS-KPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKS 263 Query: 254 LISRIFVADPATRISIPEIKTHSW 277 LI + +P RI+ + W Sbjct: 264 LIDSMLTVNPKKRITADQALKVPW 287 >3KK8-A nrPDB Length = 284 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 134/263 (50%), Gaps = 7/263 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 SD YD +++G G F V R K T A K I + + + ++RE R L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I + ++ + +GGEL+E I +SE +A QQ+L ++YCHS Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HR+LK EN LL + +K+ DFG + GTP Y++PEVL + Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 K D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE L Sbjct: 185 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 241 Query: 255 ISRIFVADPATRISIPEIKTHSW 277 I + +P RI+ + W Sbjct: 242 IDSMLTVNPKKRITADQALKVPW 264 >4RGJ-A nrPDB Length = 520 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 94/278 (33%), Positives = 144/278 (51%), Gaps = 14/278 (5%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KID-ENVQREIINHRSLR 74 +++Y +K +G G+FG L RDK T A+K I + K D E++ RE+ + L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NI++ E + ++ + +GGEL++ I + RF E +A +Q+LSG++Y H Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHK 178 Query: 135 MQICHRDLKLENTLLDGSPAPRL--KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 + HRDLK EN LL+ + KI DFG S + K +GT YIAP+V L Sbjct: 179 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV-LHG 237 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS--IPDDIRISPE 250 YD K D+WSCGV LY++L G PF E ++++ + KY+ +P +IS + Sbjct: 238 TYDEK-CDIWSCGVILYILLSGCPPFNGSNE----YDILKKVEAGKYTFDLPQFKKISDK 292 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 LI ++ + A RIS + H W D +N Sbjct: 293 AKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLN 330 >2JDO-A nrPDB Length = 342 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 138/268 (51%), Gaps = 19/268 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSL---RHPN 77 +D++K +G G FG L+R+K T A+K + + I ++ V + R L RHP Sbjct: 12 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 71 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 + K T L +MEYA+GGEL+ + F+E+ ARF+ +++S + Y HS + Sbjct: 72 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 131 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQEYDG 196 +RD+KLEN +LD +KI DFG K + K+ GTP Y+APEVL +Y G Sbjct: 132 VYRDIKLENLMLDKD--GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-G 188 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 + D W GV +Y M+ G PF + +D+ + + IL + P +SPE L++ Sbjct: 189 RAVDWWGLGVVMYEMMCGRLPFYN----QDHERLFELILMEEIRFPRT--LSPEAKSLLA 242 Query: 257 RIFVADPATRIS-----IPEIKTHSWFL 279 + DP R+ E+ H +FL Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 >1ZWS-A nrPDB Length = 288 Score = 141 bits (356), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 88/269 (32%), Positives = 139/269 (51%), Gaps = 16/269 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-------RGDKIDENVQREIINHRS 72 D YD +++GSG F + + R+K T A K+I+ R E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 + H N++ +V T + +I+E SGGEL++ + SE+EA F +Q+L GV+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 133 HSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 H+ +I H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RIS 248 E G AD+WS GV Y++L GA PF + ++T+ I SV Y ++ S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITSVSYDFDEEFFSHTS 246 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 I ++ V + R++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >5D9K-A nrPDB Length = 330 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 89/276 (32%), Positives = 154/276 (55%), Gaps = 27/276 (9%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLT----KELVAVKYIERG-----DKIDENVQREII 68 D +++ +K +G G+FG L++ K++ ++L A+K +++ D++ ++R+I+ Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 + HP IV+ T L +I+++ GG+L+ R+ F+E++ +F+ +L Sbjct: 87 V--EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 144 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPE 187 + + HS+ I +RDLK EN LLD +K+ DFG SK S+ H + S GT Y+APE Sbjct: 145 LDHLHSLGIIYRDLKPENILLD--EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 V+ R+ + + AD WS GV ++ ML G PF+ +D ++T+ IL K +P + Sbjct: 203 VVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQ--FL 255 Query: 248 SPECCHLISRIFVADPATRI-----SIPEIKTHSWF 278 SPE L+ +F +PA R+ + EIK HS+F Sbjct: 256 SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 291 >3HDN-A nrPDB Length = 373 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 96/297 (32%), Positives = 146/297 (49%), Gaps = 20/297 (6%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR 65 + GP P SD + F+K IG G+FG L R K + AVK +++ + + ++ Sbjct: 25 INLGPSSNPHAKPSD-FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEK 83 Query: 66 EIINHRSL-----RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 I++ R++ +HP +V T L +++Y +GGEL+ + F E ARF Sbjct: 84 HIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARF 143 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-G 179 + ++ S + Y HS+ I +RDLK EN LLD + + DFG K ++ H+ ST G Sbjct: 144 YAAEIASALGYLHSLNIVYRDLKPENILLDSQ--GHIVLTDFGLCKENIEHNSTTSTFCG 201 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 TP Y+APEVL +Q YD + D W G LY ML G PF Y + + L +K Sbjct: 202 TPEYLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 260 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIP----EIKTHSWFLKNLPADLMNESNT 292 +I + R HL+ + D R+ EIK+H +F DL+N+ T Sbjct: 261 NITNSAR------HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKIT 311 >3KN6-A nrPDB Length = 325 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 88/261 (33%), Positives = 137/261 (52%), Gaps = 11/261 (4%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEV 84 K +G G+F + R K + + AVK I + +++ N Q+EI + HPNIV+ EV Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK--RMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 H ++ME +GGEL+ERI FSE EA + ++L+S VS+ H + + HRDLK Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 145 ENTLL-DGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQEYDGKIADVW 202 EN L D + +KI DFG+++ +QP K+ T Y APE+L + YD + D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLW 193 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK---YSIPDDI--RISPECCHLISR 257 S GV LY ML G PF+ + ++ + +K +S + +S E LI Sbjct: 194 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 253 Query: 258 IFVADPATRISIPEIKTHSWF 278 + DP R+ + ++ + W Sbjct: 254 LLTVDPNKRLKMSGLRYNEWL 274 >2A27-A nrPDB Length = 321 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 87/269 (32%), Positives = 140/269 (52%), Gaps = 16/269 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-------RGDKIDENVQREIINHRS 72 D YD +++GSG F + + R+K T A K+I+ R E ++RE+ R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 + H N++ +V T + +I+E SGGEL++ + SE+EA F +Q+L GV+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 133 HSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 H+ +I H DLK EN +L P P +K+ DFG + + K+ GTP ++APE+ + Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RIS 248 E G AD+WS GV Y++L GA PF + ++T+ I +V Y ++ + S Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTK----QETLANITAVSYDFDEEFFSQTS 246 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 I ++ V + R++I E H W Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4MVF-A nrPDB Length = 506 Score = 140 bits (353), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 91/262 (34%), Positives = 135/262 (51%), Gaps = 10/262 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLRHP 76 D+Y + +G G +G DK+T +L A+K E+ D++ +N+ R EI + L HP Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRL-KNINRFFQEIEIMKKLDHP 114 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 NIV+ E ++ +IME SG EL++ I G F+E A +Q+ S + Y HS+ Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 137 ICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I HRDLK EN L + LKI DFG SK+ + GTP Y+AP+V L +YD Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQV-LDGKYD 233 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D+WS GV +Y +L G PF + +K + + D IS + +LI Sbjct: 234 KK-CDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFC--FYENDWGSISSDAKNLI 290 Query: 256 SRIFVADPATRISIPEIKTHSW 277 +++ +P R +I E H W Sbjct: 291 TKLLTYNPNERCTIEEALNHPW 312 >4YZB-A nrPDB Length = 491 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 93/265 (35%), Positives = 136/265 (51%), Gaps = 9/265 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLR- 74 SDRY + +G G+FG L +DK+T + AVK I + K D+ + + + Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNI++ E + ++ E +GGEL++ I + RFSE +A +Q+LSG++Y H Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 148 Query: 135 MQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 +I HRDLK EN LL+ ++I DFG S + K +GT YIAPEV L Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEV-LHGT 207 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 YD K DVWS GV LY++L G PF E D K +++ + +P ++S Sbjct: 208 YDEK-CDVWSTGVILYILLSGCPPFNGANEF-DILKKVEK-GKFTFDLPQWKKVSEPAKD 264 Query: 254 LISRIFVADPATRISIPEIKTHSWF 278 LI ++ P RIS + H W Sbjct: 265 LIRKMLAYVPTMRISARDALEHEWL 289 >2V7O-A nrPDB Length = 336 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 93/282 (32%), Positives = 141/282 (50%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 +D Y +++G G F V R K + A K I + + + ++RE R L+H Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I ++ + +GGEL+E I +SE +A Q+L V++ H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 I HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D D K Q+I + Y P+ ++PE Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWD----EDQHKLYQQIKAGAYDFPSPEWDTVTPEA 264 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 +LI+++ +PA RI+ + H W ++ A +M+ T Sbjct: 265 KNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQET 306 >5YV8-A nrPDB Length = 298 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 100/295 (33%), Positives = 144/295 (48%), Gaps = 49/295 (16%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID------------------- 60 ++Y +IG G++GV +L ++ A+K + + I Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 61 --------ENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNA 110 E V +EI + L HPN+V+ EV+ P HL ++ E + G + E + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 131 Query: 111 GRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSK-- 166 SED+ARF+FQ L+ G+ Y H +I HRD+K N L+ DG +KI DFG S Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDG----HIKIADFGVSNEF 187 Query: 167 --SSVLHSQPKSTVGTPAYIAPEVL--LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE 222 S L S +TVGTPA++APE L R+ + GK DVW+ GVTLY + G PF D Sbjct: 188 KGSDALLS---NTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDER 244 Query: 223 EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSW 277 + K I S PD I+ + LI+R+ +P +RI +PEIK H W Sbjct: 245 IMCLHSK----IKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >3MV5-A nrPDB Length = 342 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 106/344 (30%), Positives = 165/344 (47%), Gaps = 44/344 (12%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSL---RH 75 + ++++K +G G FG L+++K T A+K +++ + ++ V + +R L RH Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y HS Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 129 Query: 136 Q-ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQE 193 + + +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 130 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 187 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y G+ D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 188 Y-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPRT--LGPEAKS 240 Query: 254 LISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 L+S + DP R+ EI H +F A ++ + + P +P Sbjct: 241 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----AGIVWQHVYEKKLSPPFKP------ 289 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNL------DLDDDMDDFDSE 346 Q+ SE R D+ T + D DD M+ DSE Sbjct: 290 --QVTSETD-----TRYFDEEFTAQMITITPPDQDDSMECVDSE 326 >6FDY-U nrPDB Length = 276 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 87/271 (32%), Positives = 143/271 (52%), Gaps = 11/271 (4%) Query: 20 DRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRH 75 D + + +GSG + V + K T+E+VA+K + + EN+ EI + +RH Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRH 70 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P+IV+ K+ ++ +IME+ +GG+L I E AR F QQL S + + H Sbjct: 71 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 130 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I H DLK +N LL P LK+ DFG+++ + G+P Y+APE++ +++YD Sbjct: 131 NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYD 190 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY-SIPDDIRISPECCHL 254 ++ D+WS GV LY L G PF R + + ++I S + +P +S +C L Sbjct: 191 ARV-DLWSMGVILYEALFGQPPFAS----RSFSELEEKIRSNRVIELPLRPLLSRDCRDL 245 Query: 255 ISRIFVADPATRISIPEIKTHSWF-LKNLPA 284 + R+ DP+ RIS + H W L+++P+ Sbjct: 246 LQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >3Q5I-A nrPDB Length = 504 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 104/343 (30%), Positives = 165/343 (48%), Gaps = 36/343 (10%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERG--------------DKIDENVQREIINH 70 V+ +GSG +G L ++K A+K I++ +K E + EI Sbjct: 41 VRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLL 100 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 +SL HPNI++ +V + ++ E+ GGEL+E+I N +F E +A +Q+LSG+ Sbjct: 101 KSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGIC 160 Query: 131 YCHSMQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H I HRD+K EN LL+ + +KI DFG S + + +GT YIAPEV Sbjct: 161 YLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEV- 219 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--SIPDDIRI 247 L+++Y+ K DVWSCGV +Y++L G PF + + I+++ KY D I Sbjct: 220 LKKKYNEK-CDVWSCGVIMYILLCGYPPFGGQND----QDIIKKVEKGKYYFDFNDWKNI 274 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGS---------QFQE 298 S E LI + D R + E W K A+ +N+S+ + +F+ Sbjct: 275 SDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK--YANNINKSDQKTLCGALSNMRKFEG 332 Query: 299 PEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 ++ Q+ I+ I S+ T R D F + + D +D Sbjct: 333 SQKLAQA--AILFIGSKLTTLEERKELTDIFKKLDKNGDGQLD 373 >5KCV-A nrPDB Length = 460 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 140/270 (51%), Gaps = 20/270 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSL---RH 75 + ++++K +G G FG L+++K T A+K +++ + ++ V + +R L RH Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y HS Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 281 Query: 136 Q-ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQE 193 + + +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 282 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 339 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y G+ D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 340 Y-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPRT--LGPEAKS 392 Query: 254 LISRIFVADPATRIS-----IPEIKTHSWF 278 L+S + DP R+ EI H +F Sbjct: 393 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 422 >2Z7Q-A nrPDB Length = 321 Score = 137 bits (345), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 88/276 (31%), Positives = 150/276 (54%), Gaps = 27/276 (9%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTK----ELVAVKYIERG-----DKIDENVQREII 68 D ++ +K +G G+FG L+R K+T+ L A+K +++ D++ ++R+I+ Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVR-KVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDIL 84 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 + HP +V+ T L +I+++ GG+L+ R+ F+E++ +F+ +L G Sbjct: 85 A--DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 142 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPE 187 + + HS+ I +RDLK EN LLD +K+ DFG SK ++ H + S GT Y+APE Sbjct: 143 LDHLHSLGIIYRDLKPENILLD--EEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 V+ RQ + AD WS GV ++ ML G+ PF+ +D ++T+ IL K +P + Sbjct: 201 VVNRQGHSHS-ADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQ--FL 253 Query: 248 SPECCHLISRIFVADPATRI-----SIPEIKTHSWF 278 S E L+ +F +PA R+ EIK H ++ Sbjct: 254 STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFY 289 >4B8L-A nrPDB Length = 286 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 139/269 (51%), Gaps = 20/269 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLRH 75 D +D + +G G FG L R+K K ++A+K + + + ++ ++REI LRH Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI+R + +++E+A GELY+ + GRF E + F ++L + YCH Sbjct: 75 PNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHER 134 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVLLRQ 192 ++ HRD+K EN L+ LKI DFG+S +H+ + ++ GT Y+ PE++ + Sbjct: 135 KVIHRDIKPENLLMGYKGE--LKIADFGWS----VHAPSLRRRTMCGTLDYLPPEMIEGK 188 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 +D K+ D+W GV Y LVG PF+ P + +T +RI++V P +S Sbjct: 189 THDEKV-DLWCAGVLCYEFLVGMPPFDSP----SHTETHRRIVNVDLKFPPF--LSDGSK 241 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLKN 281 LIS++ P R+ + + H W N Sbjct: 242 DLISKLLRYHPPQRLPLKGVMEHPWVKAN 270 >2YCR-A nrPDB Length = 323 Score = 134 bits (338), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 96/293 (32%), Positives = 140/293 (47%), Gaps = 22/293 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER-----GDKIDE----NVQREIINH 70 D Y K +GSG G +L ++ T + VA+K I + G + NV+ EI Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + L HP I++ K + I++E GGEL++++ R E + +F Q+L V Sbjct: 70 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H I HRDLK EN LL L KI DFG+SK S ++ GTP Y+APEVL Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 190 LRQEYDG--KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-- 245 + G + D WS GV L++ L G PF E R +I S KY+ ++ Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWF----LKNLPADLMNESNTGS 294 +S + L+ ++ V DP R + E H W +K DL++E N + Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENEST 298 >5JZN-A nrPDB Length = 280 Score = 134 bits (337), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 84/267 (31%), Positives = 137/267 (51%), Gaps = 15/267 (5%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD--KIDENVQREIINHRSLRHP 76 ++RY + IG GNF V + ++ T A+K I++ + +Q E+ R ++HP Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 NIV E + PT L ++ME GG+L++ I + +++E +A L S + Y HS+ Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 137 ICHRDLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 I HRD+K EN L+ DGS + LK+ DFG ++++ + GTP Y+APE++ Sbjct: 138 IVHRDIKPENLLVYEHQDGSKS--LKLGDFGL--ATIVDGPLYTVCGTPTYVAPEIIAET 193 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL--SVKYSIPDDIRISPE 250 Y K+ D+W+ GV Y++L G PF + D +IL V + P +S Sbjct: 194 GYGLKV-DIWAAGVITYILLCGFPPFRGSGD--DQEVLFDQILMGQVDFPSPYWDNVSDS 250 Query: 251 CCHLISRIFVADPATRISIPEIKTHSW 277 LI+ + + D R S ++ H W Sbjct: 251 AKELITMMLLVDVDQRFSAVQVLEHPW 277 >1KOA-A nrPDB Length = 491 Score = 134 bits (336), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 87/277 (31%), Positives = 139/277 (50%), Gaps = 15/277 (5%) Query: 10 PLDMPIMHDS--DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQRE 66 P + I HD D YD +++G+G FGV + ++ T A K++ + D E V++E Sbjct: 39 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKE 98 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQL 125 I LRHP +V + + +I E+ SGGEL+E++ + + SEDEA + +Q+ Sbjct: 99 IQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQV 158 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 G+ + H H DLK EN + + LK+ DFG + K T GT + A Sbjct: 159 CKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAA 218 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF--EDPEEPRDYRKTIQRILSVKYSIPD 243 PEV + G D+WS GV Y++L G PF E+ +E T++ + S +++ D Sbjct: 219 PEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDE------TLRNVKSCDWNMDD 271 Query: 244 DI--RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 IS + I ++ +ADP TR++I + H W Sbjct: 272 SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >3UTO-A nrPDB Length = 573 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 87/277 (31%), Positives = 139/277 (50%), Gaps = 15/277 (5%) Query: 10 PLDMPIMHDS--DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQRE 66 P + I HD D YD +++G+G FGV + ++ T A K++ + D E V++E Sbjct: 145 PQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKE 204 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQL 125 I LRHP +V + + +I E+ SGGEL+E++ + + SEDEA + +Q+ Sbjct: 205 IQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQV 264 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 G+ + H H DLK EN + + LK+ DFG + K T GT + A Sbjct: 265 CKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAA 324 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF--EDPEEPRDYRKTIQRILSVKYSIPD 243 PEV + G D+WS GV Y++L G PF E+ +E T++ + S +++ D Sbjct: 325 PEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDE------TLRNVKSCDWNMDD 377 Query: 244 DI--RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 IS + I ++ +ADP TR++I + H W Sbjct: 378 SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >5N23-A nrPDB Length = 352 Score = 131 bits (329), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 81/268 (30%), Positives = 138/268 (51%), Gaps = 19/268 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH---- 75 D+++ ++ +G+G+FG L++ K T A+K +++ + +N + ++ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L +++EYA GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +K+ DFG++K V P + GTP Y+APE++L + Y+ Sbjct: 162 DLIYRDLKPENLLIDQQGY--IKVADFGFAK-RVKGRTPWTLCGTPEYLAPEIILSKGYN 218 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y K I+S K P S + L+ Sbjct: 219 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 271 Query: 256 SRIFVADPATRI-----SIPEIKTHSWF 278 + D R + +IK H WF Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >5XZW-A nrPDB Length = 471 Score = 130 bits (328), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 88/267 (32%), Positives = 125/267 (46%), Gaps = 18/267 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G F + ++ T + AVK I + I + V RE+ + L HP IVR K Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 263 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 ++ME+ SGG+L + + G ED R +Q+L+ + Y HSM I HRDLK + Sbjct: 264 EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPD 323 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL-------------RQ 192 N L++ +KI DFG +K S K+ GT AY+APEV+ R Sbjct: 324 NILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERN 383 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 EY + D+WS G +YV+L G PF + + Y K I R S D RIS E Sbjct: 384 EYS-SLVDMWSMGCLVYVILTGHLPFSGSTQDQLY-KQIGR-GSYHEGPLKDFRISEEAR 440 Query: 253 HLISRIFVADPATRISIPEIKTHSWFL 279 I + DP R + + H W + Sbjct: 441 DFIDSLLQVDPNNRSTAAKALNHPWIV 467 >2X4F-A nrPDB Length = 373 Score = 130 bits (328), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 9/255 (3%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVIL 86 +G G FG + T +A K I+ RG K E V+ EI L H N+++ + Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFE 156 Query: 87 TPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 + + ++MEY GGEL++RI + +E + F +Q+ G+ + H M I H DLK E Sbjct: 157 SKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPE 216 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCG 205 N L A ++KI DFG ++ + K GTP ++APEV + ++ D+WS G Sbjct: 217 NILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV-VNYDFVSFPTDMWSVG 275 Query: 206 VTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD--IRISPECCHLISRIFVADP 263 V Y++L G PF + +T+ IL+ ++ + D+ IS E IS++ + + Sbjct: 276 VIAYMLLSGLSPFLGDNDA----ETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEK 331 Query: 264 ATRISIPEIKTHSWF 278 + RIS E H W Sbjct: 332 SWRISASEALKHPWL 346 >4NIF-A nrPDB Length = 333 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/272 (35%), Positives = 139/272 (51%), Gaps = 25/272 (9%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 SD Y + IG G++ + K T AVK I++ K D + + EI+ R +HPNI Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEIL-LRYGQHPNI 64 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + K+V H+ ++ E GGEL ++I FSE EA F + V Y HS + Sbjct: 65 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 139 HRDLKLENTL-LDGSPAPR-LKICDFGYSKSSVLHSQPKSTVGTPAY----IAPEVLLRQ 192 HRDLK N L +D S P L+ICDFG++K L ++ + TP Y +APEVL RQ Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQ--LRAE-NGLLMTPCYTANFVAPEVLKRQ 181 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFED-----PEEPRDYRKTIQRILSVKYSIPDD--I 245 YD + D+WS G+ LY ML G PF + PEE + RI S K+++ Sbjct: 182 GYD-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEE------ILTRIGSGKFTLSGGNWN 234 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSW 277 +S L+S++ DP R++ ++ H W Sbjct: 235 TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >4I6B-A nrPDB Length = 308 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 84/276 (30%), Positives = 144/276 (52%), Gaps = 16/276 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIIN-----HRSLRH 75 RY K +G G F M D ++ A K I ++ + QRE I+ HR L H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPH-SRVSKPHQREKIDKEIELHRILHH 87 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 ++V+F ++ I++EY S + + +E E R++ +Q++SG+ Y H Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ 147 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 +I HRDLKL N ++ S LK+ DFG ++ L + ++ GTP Y++PEVL +Q + Sbjct: 148 EILHRDLKLGNFFINES--MELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH 205 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 G +D+W+ G +Y ML+G PFE + ++T + I +Y++P + ++P HL Sbjct: 206 -GAESDIWALGCVMYTMLLGRPPFETT----NLKETYRSIREARYTMPSSL-LAP-AKHL 258 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 I+ + +P R S+ +I H +F + D ++ S Sbjct: 259 IASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSS 294 >3I6U-A nrPDB Length = 419 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 94/288 (32%), Positives = 138/288 (47%), Gaps = 22/288 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER-----GDKIDE----NVQREIINH 70 D Y K +GSG G +L ++ T + VA++ I + G + NV+ EI Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + L HP I++ K + I++E GGEL++++ R E + +F Q+L V Sbjct: 195 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H I HRDLK EN LL L KI DFG+SK S ++ GTP Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 190 LRQEYDG--KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-- 245 + G + D WS GV L++ L G PF E R +I S KY+ ++ Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWF----LKNLPADLMNE 289 +S + L+ ++ V DP R + E H W +K DL++E Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE 418 >5DYK-A nrPDB Length = 853 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 130/260 (50%), Gaps = 17/260 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----HPNIVRFKE 83 IG G FG +L+ K TK A+K + + I+ N Q I R + HP I+R Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVR 606 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + + E +GGELY+ I G S+ +A+F+ ++ + Y H I +RDLK Sbjct: 607 TFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLK 666 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD +K+ DFG +K + + + VGTP Y+APEV+L + Y G D+W+ Sbjct: 667 PENILLD--KQGYVKLIDFGCAKK--VQGRAYTLVGTPHYMAPEVILGKGY-GCTVDIWA 721 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 G+ LY + G PF + EE D + + IL+ + + PD + + +L+ R+ P Sbjct: 722 LGICLYEFICGPLPFGNDEE--DQLEIFRDILTGQLTFPDYV-TDTDSINLMKRLLCRLP 778 Query: 264 ATRI-----SIPEIKTHSWF 278 RI +IK H +F Sbjct: 779 QGRIGCSINGFKDIKDHPFF 798 >5X3F-B nrPDB Length = 393 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 138/268 (51%), Gaps = 20/268 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR----SLRH 75 D++D +K +G+G+FG L++ K + A+K +++ + +N + ++ Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L ++MEY +GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 144 PFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 203 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 204 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 259 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y K I+S K P S + L+ Sbjct: 260 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 312 Query: 256 SRIFVADPATRI-----SIPEIKTHSWF 278 + D R + +IK H WF Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >2I0E-A nrPDB Length = 353 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 90/268 (33%), Positives = 134/268 (50%), Gaps = 20/268 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RHP 76 ++F+ +G G+FG L K T EL AVK +++ I D++V+ ++ R L + P Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 82 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 141 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEYD 195 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Y Sbjct: 142 IIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY- 198 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 GK D W+ GV LY ML G PFE +E + Q I+ + P +S E + Sbjct: 199 GKSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKS--MSKEAVAIC 252 Query: 256 SRIFVADPATRISI-PE----IKTHSWF 278 + P R+ PE IK H++F Sbjct: 253 KGLMTKHPGKRLGCGPEGERDIKEHAFF 280 >4JG6-A nrPDB Length = 355 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 98/289 (33%), Positives = 144/289 (49%), Gaps = 27/289 (9%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 +D Y+ +DIG G++ V + K T AVK I++ K D + EI+ R +HPNI Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK-SKRDPTEEIEIL-LRYGQHPNI 91 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + K+V ++ ++ E GGEL ++I FSE EA + V Y H+ + Sbjct: 92 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 139 HRDLKLENTL-LDGSPAPR-LKICDFGYSKSSVLHSQPKSTVGTPAY----IAPEVLLRQ 192 HRDLK N L +D S P ++ICDFG++K L ++ + TP Y +APEVL RQ Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQ--LRAE-NGLLMTPCYTANFVAPEVLERQ 208 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFED-----PEEPRDYRKTIQRILSVKYSIPDDI-- 245 YD D+WS GV LY ML G PF + PEE + RI S K+S+ Sbjct: 209 GYDAA-CDIWSLGVLLYTMLTGYTPFANGPDDTPEE------ILARIGSGKFSLSGGYWN 261 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFLK--NLPADLMNESNT 292 +S L+S++ DP R++ + H W + LP +N + Sbjct: 262 SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDA 310 >4C0T-A nrPDB Length = 974 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 132/273 (48%), Gaps = 26/273 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE------NVQREIINHRSLRH 75 + F K++G G++ L DK+T + AVK +++ I E N+++ +N S R Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 ++ L +++YAS GEL I +E+ R F Q+L + Y H Sbjct: 328 -GVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDN 386 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGY----------SKSSVLHSQPKSTVGTPAYIA 185 + HRDLK EN LLD R++I DFG S+ + + KS VGT Y++ Sbjct: 387 GVIHRDLKPENILLDD--KMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE LL +Y GK DVW+ G +Y M+ G PF+ E ++K + + P I Sbjct: 445 PE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTII 503 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 R LI +I V P+ R +IPEI+ H +F Sbjct: 504 R------DLIKKILVLQPSRRATIPEIQKHYFF 530 >3PFQ-A nrPDB Length = 674 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 90/268 (33%), Positives = 134/268 (50%), Gaps = 20/268 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RHP 76 ++F+ +G G+FG L K T EL AVK +++ I D++V+ ++ R L + P Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 403 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG 462 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEYD 195 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Y Sbjct: 463 IIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY- 519 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 GK D W+ GV LY ML G PFE +E + Q I+ + P +S E + Sbjct: 520 GKSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKS--MSKEAVAIC 573 Query: 256 SRIFVADPATRISI-PE----IKTHSWF 278 + P R+ PE IK H++F Sbjct: 574 KGLMTKHPGKRLGCGPEGERDIKEHAFF 601 >4B6L-A nrPDB Length = 281 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 129/265 (48%), Gaps = 14/265 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIIN----HRSLRHPNIVRFKE 83 +G G F D T AVK I + + + +I+N HR L+H +IVRF Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 76 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 ++ I +E S L E E R++ +Q+LSG+ Y H I HRDLK Sbjct: 77 HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLK 136 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIADVW 202 L N + + LK+ DFG + Q K T+ GTP Y+APEVLLRQ + G ADVW Sbjct: 137 LGNFFI--TENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-GPEADVW 193 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G +Y +L G+ PFE D ++T + I V Y++P + + L++ I A Sbjct: 194 SLGCVMYTLLCGSPPFETA----DLKETYRCIKQVHYTLPASLSLPAR--QLLAAILRAS 247 Query: 263 PATRISIPEIKTHSWFLKNLPADLM 287 P R SI +I H +F K D + Sbjct: 248 PRDRPSIDQILRHDFFTKGYTPDRL 272 >4RA4-A nrPDB Length = 355 Score = 127 bits (320), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 20/268 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RHP 76 ++F+ +G G+FG L K T+EL A+K +++ I D++V+ ++ R L + P Sbjct: 22 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 81 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 + + T L +MEY +GG+L I G+F E +A F+ ++ G+ + H Sbjct: 82 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG 141 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYD 195 I +RDLKL+N +LD +KI DFG K ++ T GTP YIAPE++ Q Y Sbjct: 142 IIYRDLKLDNVMLDSE--GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY- 198 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 GK D W+ GV LY ML G PF+ +E + Q I+ S P +S E + Sbjct: 199 GKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKS--LSKEAVSIC 252 Query: 256 SRIFVADPATRISI-PE----IKTHSWF 278 + PA R+ PE ++ H++F Sbjct: 253 KGLMTKHPAKRLGCGPEGERDVREHAFF 280 >5F9E-A nrPDB Length = 353 Score = 127 bits (318), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 85/265 (32%), Positives = 138/265 (52%), Gaps = 18/265 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RHP 76 ++ K +G G+FG L K T + A+K +++ + D++V+ ++ R L HP Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 + T +L +MEY +GG+L I + +F A F+ +++ G+ + HS Sbjct: 81 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG 140 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLRQEYD 195 I +RDLKL+N LLD +KI DFG K ++L ++ GTP YIAPE+LL Q+Y+ Sbjct: 141 IVYRDLKLDNILLDKD--GHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYN 198 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR-ISPECCHL 254 + D WS GV LY ML+G PF +E + S++ P R + E L Sbjct: 199 HSV-DWWSFGVLLYEMLIGQSPFHGQDEEELFH-------SIRMDNPFYPRWLEKEAKDL 250 Query: 255 ISRIFVADPATRISI-PEIKTHSWF 278 + ++FV +P R+ + +I+ H F Sbjct: 251 LVKLFVREPEKRLGVRGDIRQHPLF 275 >3IS5-A nrPDB Length = 285 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 86/272 (31%), Positives = 137/272 (50%), Gaps = 24/272 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D + F + +GSG FG L+ ++ + +K I +R E ++ EI +SL HPN Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPN 81 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNA---GR-FSEDEARFFFQQLLSGVSYCH 133 I++ EV ++ I+ME GGEL ERI +A G+ SE +Q+++ ++Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 134 SMQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 S + H+DLK EN L D SP +KI DFG ++ + GT Y+APEV R Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRD 201 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPF-----EDPEEPRDYRKTIQRILSVKYSIPDDIR- 246 D+WS GV +Y +L G PF E+ ++ Y++ Y++ + R Sbjct: 202 VTFK--CDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEP-------NYAV--ECRP 250 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 ++P+ L+ ++ DP R S ++ H WF Sbjct: 251 LTPQAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >4WB7-A nrPDB Length = 405 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 20/268 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR----SLRH 75 D+++ +K +G+G+FG L++ K T A+K +++ + +N + ++ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L ++MEY GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 215 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 216 DLIYRDLKPENLLIDQQGY--IQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 271 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y K I+S K P S + L+ Sbjct: 272 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 324 Query: 256 SRIFVADPATRI-----SIPEIKTHSWF 278 + D R + +IK H WF Sbjct: 325 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >4PDS-A nrPDB Length = 347 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 86/265 (32%), Positives = 123/265 (46%), Gaps = 18/265 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G F + ++ T + +VK I + I + V RE+ + L HP IVR K Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 98 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 ++ME+ SGG+L + + G ED R +Q+L+ + Y HSM I HRDLK + Sbjct: 99 EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPD 158 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL-------------RQ 192 N L++ +KI FG +K S K+ GT AY+APEV+ R Sbjct: 159 NILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERN 218 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 EY + D+WS G +YV+L G PF + + Y K I R S D RIS E Sbjct: 219 EYS-SLVDMWSMGCLVYVILTGHLPFSGSTQDQLY-KQIGR-GSYHEGPLKDFRISEEAR 275 Query: 253 HLISRIFVADPATRISIPEIKTHSW 277 I + DP R + + H W Sbjct: 276 DFIDSLLQVDPNNRSTAAKALNHPW 300 >3TXO-A nrPDB Length = 353 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 79/211 (37%), Positives = 114/211 (54%), Gaps = 11/211 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI--DENVQREIINHRSL---- 73 D ++F++ +G G+FG L R K T +L AVK +++ D I D++V+ + R L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKK-DVILQDDDVECTMTEKRILSLAR 81 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 HP + + TP L +ME+ +GG+L I + RF E ARF+ +++S + + H Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQ 192 I +RDLKL+N LLD K+ DFG K + + +T GTP YIAPE+L Sbjct: 142 DKGIIYRDLKLDNVLLDHE--GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 199 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 Y G D W+ GV LY ML G PFE E Sbjct: 200 LY-GPAVDWWAMGVLLYEMLCGHAPFEAENE 229 >5FET-A nrPDB Length = 847 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 83/260 (31%), Positives = 129/260 (49%), Gaps = 17/260 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----HPNIVRFKE 83 IG G FG +L+ K T+ A+K + + I N Q I R + HP I+R Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVR 600 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + E +GGELY+ I G S+ +A+F+ ++ + Y H I +RDLK Sbjct: 601 TFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLK 660 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN LLD +K+ DFG +K + + + VGTP Y+APEV+L + Y G D+W+ Sbjct: 661 PENILLD--KQGYVKLIDFGCAKK--IQGRAYTLVGTPHYMAPEVILGKGY-GCTVDIWA 715 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 GV LY + G PF + +E D + + IL+ + + PD + + +L+ R+ P Sbjct: 716 LGVCLYEFICGPLPFGNDQE--DQLEIFRDILTGQLTFPDYVS-DQDSINLMKRLLCRLP 772 Query: 264 ATRI-----SIPEIKTHSWF 278 RI +IK H++F Sbjct: 773 QGRIGCSINGFKDIKEHAFF 792 >6CCF-A nrPDB Length = 290 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 83/228 (36%), Positives = 122/228 (53%), Gaps = 18/228 (7%) Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEA 118 E V +EI + L H N+V+ EV+ P +L ++ + G + E C+ FSE++A Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDK-PFSEEQA 131 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLH-SQPK 175 R + + ++ G+ Y H +I HRD+K N LL DG +KI DFG S + +Q Sbjct: 132 RLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDG----HVKIADFGVSNQFEGNDAQLS 187 Query: 176 STVGTPAYIAPEVL--LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 ST GTPA++APE + Q + GK DVW+ GVTLY + G PF D D+ + R Sbjct: 188 STAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID-----DFILALHR 242 Query: 234 -ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 I + P++ IS E LI ++ +P TRI +P+IK H W K Sbjct: 243 KIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >4AF3-A nrPDB Length = 292 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 84/283 (29%), Positives = 143/283 (50%), Gaps = 21/283 (7%) Query: 7 TTGPLDMPIMHDS-DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDE 61 ++G D+ H + D ++ + +G G FG L R+K + +VA+K + + + ++ Sbjct: 9 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH 68 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFF 121 ++REI L HPNI+R + +I+EYA GELY+ + + F E Sbjct: 69 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI 128 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTV 178 ++L + YCH ++ HRD+K EN LL LKI DFG+S +H+ + K+ Sbjct: 129 MEELADALMYCHGKKVIHRDIKPENLLLGLKGE--LKIADFGWS----VHAPSLRRKTMC 182 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GT Y+ PE++ + ++ K+ D+W GV Y +LVG PFE YR+ ++ L Sbjct: 183 GTLDYLPPEMIEGRMHNEKV-DLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFP 241 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 S+P + LIS++ +P+ R+ + ++ H W N Sbjct: 242 ASVPTGAQ------DLISKLLRHNPSERLPLAQVSAHPWVRAN 278 >3DB8-A nrPDB Length = 317 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 132/263 (50%), Gaps = 14/263 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHP 76 RY + +G G F + D TKE+ A K + + + E + EI H+SL +P Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNP 102 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 ++V F + +++E L E +E EAR+F +Q + GV Y H+ + Sbjct: 103 HVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNR 162 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + HRDLKL N L+ +KI DFG +K + K GTP YIAPEVL ++ + Sbjct: 163 VIHRDLKLGNLFLNDDMD--VKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHS 220 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 ++ D+WS G LY +LVG PFE ++T RI +YS+P I+P LI Sbjct: 221 FEV-DIWSLGCILYTLLVGKPPFET----SCLKETYIRIKKNEYSVPR--HINPVASALI 273 Query: 256 SRIFVADPATRISIPEIKTHSWF 278 R+ ADP R S+ E+ T +F Sbjct: 274 RRMLHADPTLRPSVAELLTDEFF 296 >1NY3-A nrPDB Length = 400 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 13/263 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR----FKE 83 +G G G + +K T+E A+K ++ K V+ ++ R+ + P+IVR ++ Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIVRIVDVYEN 126 Query: 84 VILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 + L I+ME GGEL+ RI + G F+E EA + + + Y HS+ I HRD Sbjct: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 Query: 142 LKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 +K EN L P LK+ DFG++K + H+ + TP Y+APEVL ++YD K D Sbjct: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD-KSCD 245 Query: 201 VWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 +WS GV +Y++L G PF KT R+ ++ P+ +S E LI + Sbjct: 246 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 305 Query: 259 FVADPATRISIPEIKTHSWFLKN 281 +P R++I E H W +++ Sbjct: 306 LKTEPTQRMTITEFMNHPWIMQS 328 >2OZA-A nrPDB Length = 356 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 13/263 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR----FKE 83 +G G G + +K T+E A+K ++ K V+ ++ R+ + P+IVR ++ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIVRIVDVYEN 82 Query: 84 VILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 + L I+ME GGEL+ RI + G F+E EA + + + Y HS+ I HRD Sbjct: 83 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 142 Query: 142 LKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 +K EN L P LK+ DFG++K + H+ + TP Y+APEVL ++YD K D Sbjct: 143 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD-KSCD 201 Query: 201 VWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 +WS GV +Y++L G PF KT R+ ++ P+ +S E LI + Sbjct: 202 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 261 Query: 259 FVADPATRISIPEIKTHSWFLKN 281 +P R++I E H W +++ Sbjct: 262 LKTEPTQRMTITEFMNHPWIMQS 284 >6QAU-A nrPDB Length = 280 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 80/229 (34%), Positives = 120/229 (52%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKEL-VAVKYIERGDKIDENV--QREIINHRSLRHPNIVRFKEV 84 +G G F V R + + VA+K I + + + +EI + L+H NIV +V Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDV 78 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 P + ++MEY +GG+L + + G SED R F Q+ + + HS I HRDLK Sbjct: 79 QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKP 138 Query: 145 ENTLLDGS-------PAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVLLRQEYD 195 +N LL + R+KI DFG+++ LHS + G+P Y+APEV++ Q YD Sbjct: 139 QNILLSYANRRKSSVSGIRIKIADFGFAR--YLHSNMMAADLCGSPMYMAPEVIMSQHYD 196 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 K AD+WS G +Y LVG PF+ P+D R ++ S+ SIP + Sbjct: 197 AK-ADLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLMPSIPRE 243 >3KA0-A nrPDB Length = 320 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 84/263 (31%), Positives = 133/263 (50%), Gaps = 13/263 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR----FKE 83 +G G G + +K T+E A+K ++ K V+ ++ R+ + P+IVR ++ Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIVRIVDVYEN 80 Query: 84 VILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 + L I+ME GGEL+ RI + G F+E EA + + + Y HS+ I HRD Sbjct: 81 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 140 Query: 142 LKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 +K EN L P LK+ DFG++K + H+ TP Y+APEVL ++YD K D Sbjct: 141 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKYD-KSCD 199 Query: 201 VWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 +WS GV +Y++L G PF KT R+ ++ P+ +S E LI + Sbjct: 200 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 259 Query: 259 FVADPATRISIPEIKTHSWFLKN 281 +P R++I E H W +++ Sbjct: 260 LKTEPTQRMTITEFMNHPWIMQS 282 >1KOB-A nrPDB Length = 387 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 77/263 (29%), Positives = 125/263 (47%), Gaps = 9/263 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQREIINHRSLRHPNI 78 D YD ++++GSG FGV +K T + K+I +D+ V+ EI L HP + Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKL 110 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQI 137 + + + +I+E+ SGGEL++RI + SE E + +Q G+ + H I Sbjct: 111 INLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSI 170 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 H D+K EN + + A +KI DFG + K T T + APE++ R+ G Sbjct: 171 VHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPV-GF 229 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECCHLI 255 D+W+ GV YV+L G PF D +T+Q + + +D +SPE I Sbjct: 230 YTDMWAIGVLGYVLLSGLSPFAG----EDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFI 285 Query: 256 SRIFVADPATRISIPEIKTHSWF 278 + +P R+++ + H W Sbjct: 286 KNLLQKEPRKRLTVHDALEHPWL 308 >1FOT-A nrPDB Length = 318 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 142/293 (48%), Gaps = 21/293 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPN 77 + ++ +G+G+FG L+R + A+K +++ K E+ E + + HP Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I+R + +IM+Y GGEL+ + + RF A+F+ ++ + Y HS I Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDI 127 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 +RDLK EN LLD + +KI DFG++K + + GTP YIAPEV+ + Y+ Sbjct: 128 IYRDLKPENILLDKN--GHIKITDFGFAK--YVPDVTYTLCGTPDYIAPEVVSTKPYNKS 183 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 I D WS G+ +Y ML G PF D + Y K + L +D++ L+SR Sbjct: 184 I-DWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVK------DLLSR 236 Query: 258 IFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQS 305 + D + R+ ++K H WF + + L++ N + ++ P Q Q Sbjct: 237 LITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSR-NIETPYEPPIQQGQG 288 >6E9W-A nrPDB Length = 443 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 93/274 (33%), Positives = 136/274 (49%), Gaps = 22/274 (8%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----R 74 ++ Y+ VK IG G FG +L+R K T+++ A+K + + + I + R + Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 P +V+ +L ++MEY GG+L + N E ARF+ +++ + HS Sbjct: 161 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHS 219 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFG----YSKSSVLHSQPKSTVGTPAYIAPEVLL 190 M HRD+K +N LLD S LK+ DFG +K ++ + VGTP YI+PEVL Sbjct: 220 MGFIHRDVKPDNMLLDKSG--HLKLADFGTCMKMNKEGMVRCD--TAVGTPDYISPEVLK 275 Query: 191 RQE---YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 Q Y G+ D WS GV LY MLVG PF Y K + S+ + PDD I Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTF--PDDNDI 333 Query: 248 SPECCHLISRIFVADPATRI---SIPEIKTHSWF 278 S E +LI F+ D R+ + EIK H +F Sbjct: 334 SKEAKNLIC-AFLTDREVRLGRNGVEEIKRHLFF 366 >4JXF-A nrPDB Length = 266 Score = 120 bits (302), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 79/260 (30%), Positives = 131/260 (50%), Gaps = 15/260 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGD----KIDENVQREIINHRSLRHPNIVRFKE 83 +G G+F T VA+K I++ + + VQ E+ H L+HP+I+ Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 ++ +++E GE+ + N + FSE+EAR F Q+++G+ Y HS I HRDL Sbjct: 75 YFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDL 134 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVL-HSQPKSTVGTPAYIAPEVLLRQEYDGKIADV 201 L N LL + +KI DFG + + H + + GTP YI+PE+ R + G +DV Sbjct: 135 TLSNLLL--TRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH-GLESDV 191 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVA 261 WS G Y +L+G PF+ + T+ +++ Y +P + I E LI ++ Sbjct: 192 WSLGCMFYTLLIGRPPFDTD----TVKNTLNKVVLADYEMPSFLSI--EAKDLIHQLLRR 245 Query: 262 DPATRISIPEIKTHSWFLKN 281 +PA R+S+ + H + +N Sbjct: 246 NPADRLSLSSVLDHPFMSRN 265 >4WNO-A nrPDB Length = 287 Score = 120 bits (301), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 80/235 (34%), Positives = 123/235 (52%), Gaps = 16/235 (6%) Query: 21 RYDFVKD--IGSGNFGVARLMRDKLTKEL-VAVKYIERGD--KIDENVQREIINHRSLRH 75 +++F + IG G F V R + +L VAVK I + + K + +EI + L+H Sbjct: 17 KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 NIV + + ++MEY +GG+L + + SED R F QQ+ + HS Sbjct: 77 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSK 136 Query: 136 QICHRDLKLENTLLDGSPAP--------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 I HRDLK +N LL +PA R+KI DFG+++ + + G+P Y+APE Sbjct: 137 GIIHRDLKPQNILLS-NPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE 195 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 V++ Q YDGK AD+WS G +Y L G PF+ P+D R ++ ++ +IP Sbjct: 196 VIMSQHYDGK-ADLWSIGTIVYQCLTGKAPFQ-ASSPQDLRLFYEKNKTLVPTIP 248 >6BDL-A nrPDB Length = 347 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 73/267 (27%), Positives = 134/267 (50%), Gaps = 17/267 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTK-ELVAVKYIERGDKIDENVQREIINHRSLRHPN--- 77 ++ + +G G FG L++ K + + A+K +++ +D Q I + + + Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 78 -IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 IVR +L ++ME GGEL+ + + G F + RF+ ++ +Y HS Sbjct: 96 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 155 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I +RDLK EN +LD +L DFG++K + + GTP Y+APE++L + +D Sbjct: 156 IIYRDLKPENLILDHRGYAKL--VDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 213 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 AD WS G+ +Y +L G+ PF P+ + Y ++ I +++ +I+ +LI Sbjct: 214 S-ADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP----KKIAKNAANLIK 268 Query: 257 RIFVADPATRI-----SIPEIKTHSWF 278 ++ +P+ R+ + +I+ H WF Sbjct: 269 KLCRDNPSERLGNLKNGVKDIQKHKWF 295 >2OU7-A nrPDB Length = 335 Score = 117 bits (294), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 86/265 (32%), Positives = 129/265 (48%), Gaps = 15/265 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHPNIVRFKE 83 +G G F + D TKE+ A K + + + E + EI HRSL H ++V F Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + +++E L E +E EAR++ +Q++ G Y H ++ HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIADVW 202 L N L+ +KI DFG + + K + GTP YIAPEVL ++ + ++ DVW Sbjct: 169 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV-DVW 225 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G +Y +LVG PFE ++T RI +YSIP I+P LI ++ D Sbjct: 226 SIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 279 Query: 263 PATRISIPEIKTHSWFLKN-LPADL 286 P R +I E+ +F +PA L Sbjct: 280 PTARPTINELLNDEFFTSGYIPARL 304 >4J52-A nrPDB Length = 293 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 86/265 (32%), Positives = 129/265 (48%), Gaps = 15/265 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHPNIVRFKE 83 +G G F + D TKE+ A K + + + E + EI HRSL H ++V F Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + +++E L E +E EAR++ +Q++ G Y H ++ HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIADVW 202 L N L+ +KI DFG + + K + GTP YIAPEVL ++ + ++ DVW Sbjct: 142 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV-DVW 198 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G +Y +LVG PFE ++T RI +YSIP I+P LI ++ D Sbjct: 199 SIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 252 Query: 263 PATRISIPEIKTHSWFLKN-LPADL 286 P R +I E+ +F +PA L Sbjct: 253 PTARPTINELLNDEFFTSGYIPARL 277 >3TAC-A nrPDB Length = 361 Score = 117 bits (292), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 137/277 (49%), Gaps = 28/277 (10%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID------ENVQREIINHRSL 73 D Y+ + IG G F V R ++ T + AVK ++ E+++RE L Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML 85 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERI---CNAG-RFSEDEARFFFQQLLSGV 129 +HP+IV E + L ++ E+ G +L I +AG +SE A + +Q+L + Sbjct: 86 KHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEAL 145 Query: 130 SYCHSMQICHRDLKLENTLLDG--SPAPRLKICDFGYS----KSSVLHSQPKSTVGTPAY 183 YCH I HRD+K LL + AP +K+ FG + +S ++ VGTP + Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAP-VKLGGFGVAIQLGESGLVAG---GRVGTPHF 201 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI-P 242 +APEV+ R+ Y GK DVW CGV L+++L G PF +E + + I+ KY + P Sbjct: 202 MAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGKYKMNP 255 Query: 243 DDI-RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 IS L+ R+ + DPA RI++ E H W Sbjct: 256 RQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >6ED6-A nrPDB Length = 415 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 88/274 (32%), Positives = 136/274 (49%), Gaps = 22/274 (8%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----R 74 ++ YD VK IG G FG +L+R K ++++ A+K + + + I + R + Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 146 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 P +V+ +L ++MEY GG+L + N E A+F+ +++ + HS Sbjct: 147 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHS 205 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFG----YSKSSVLHSQPKSTVGTPAYIAPEVLL 190 M + HRD+K +N LLD LK+ DFG ++ ++H + VGTP YI+PEVL Sbjct: 206 MGLIHRDVKPDNMLLDKH--GHLKLADFGTCMKMDETGMVHCD--TAVGTPDYISPEVLK 261 Query: 191 RQEYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 Q D G+ D WS GV LY MLVG PF Y K + S+ + P+D I Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCF--PEDAEI 319 Query: 248 SPECCHLISRIFVADPATRI---SIPEIKTHSWF 278 S +LI F+ D R+ + EI+ H +F Sbjct: 320 SKHAKNLIC-AFLTDREVRLGRNGVEEIRQHPFF 352 >3A8W-A nrPDB Length = 345 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 143/295 (48%), Gaps = 27/295 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER-----GDKIDENVQREIINHRSLRHP 76 +D ++ IG G++ L+R K T + A+K +++ + ID + + ++ HP Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +V T + L ++EY +GG+L + + E+ ARF+ ++ ++Y H Sbjct: 71 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG 130 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYD 195 I +RDLKL+N LLD +K+ D+G K + ST GTP YIAPE+L ++Y Sbjct: 131 IIYRDLKLDNVLLDSE--GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY- 187 Query: 196 GKIADVWSCGVTLYVMLVGAYPF------EDPEE-PRDYRKTIQRILSVKYSIPDDIRIS 248 G D W+ GV ++ M+ G PF ++P++ DY Q IL + IP + + Sbjct: 188 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDY--LFQVILEKQIRIPRSLSV- 244 Query: 249 PECCHLISRIFVADPATRI------SIPEIKTHSWFLKNLPADLMNESNTGSQFQ 297 + ++ DP R+ +I+ H +F +N+ D+M + F+ Sbjct: 245 -KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF-RNVDWDMMEQKQVVPPFK 297 >4L42-A nrPDB Length = 346 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 79/273 (28%), Positives = 135/273 (49%), Gaps = 27/273 (9%) Query: 22 YDFVKDIGSGNFGVA---RLMRDKLTKELVAVKYIERG-------DKIDENVQREIINHR 71 ++ ++ +G G +G R + T ++ A+K +++ D +R I+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE-- 77 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 ++HP IV T L +I+EY SGGEL+ ++ G F ED A F+ ++ + + Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 137 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLL 190 H I +RDLK EN +L+ +K+ DFG K S+ T GT Y+APE+L+ Sbjct: 138 LHQKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 R ++ + D WS G +Y ML GA PF + +KTI +IL K ++P ++ E Sbjct: 196 RSGHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPP--YLTQE 248 Query: 251 CCHLISRIFVADPATRIS-----IPEIKTHSWF 278 L+ ++ + A+R+ E++ H +F Sbjct: 249 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >4RLP-A nrPDB Length = 288 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 79/273 (28%), Positives = 135/273 (49%), Gaps = 27/273 (9%) Query: 22 YDFVKDIGSGNFGVA---RLMRDKLTKELVAVKYIERG-------DKIDENVQREIINHR 71 ++ ++ +G G +G R + T ++ A+K +++ D +R I+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE-- 64 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 ++HP IV T L +I+EY SGGEL+ ++ G F ED A F+ ++ + + Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 124 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLL 190 H I +RDLK EN +L+ +K+ DFG K S+ T GT Y+APE+L+ Sbjct: 125 LHQKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 R ++ + D WS G +Y ML GA PF + +KTI +IL K ++P ++ E Sbjct: 183 RSGHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPP--YLTQE 235 Query: 251 CCHLISRIFVADPATRIS-----IPEIKTHSWF 278 L+ ++ + A+R+ E++ H +F Sbjct: 236 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >3ORZ-A nrPDB Length = 316 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 85/272 (31%), Positives = 128/272 (47%), Gaps = 26/272 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRHPN 77 + F K +G G+F L R+ T A+K +E+ I EN V RE L HP Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 V+ L + YA GEL + I G F E RF+ +++S + Y H I Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-----STVGTPAYIAPEVLLRQ 192 HRDLK EN LL+ ++I DFG +K VL + K S VGT Y++PE LL + Sbjct: 159 IHRDLKPENILLNED--MHIQITDFGTAK--VLSPESKQARANSFVGTAQYVSPE-LLTE 213 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 + K +D+W+ G +Y ++ G PF E Q+I+ ++Y P+ + P+ Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNE----YLIFQKIIKLEYDFPE--KFFPKAR 267 Query: 253 HLISRIFVADPATRISIPE------IKTHSWF 278 L+ ++ V D R+ E +K H +F Sbjct: 268 DLVEKLLVLDATKRLGCEEMEGYGPLKAHPFF 299 >1VZO-A nrPDB Length = 355 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 139/280 (49%), Gaps = 25/280 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRD---KLTKELVAVKYIERGDKIDE-------NVQREIIN 69 + ++ +K +G+G +G L+R T +L A+K +++ + + +R+++ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 H + P +V T T L +I++Y +GGEL+ + RF+E E + + +++ + Sbjct: 114 HIR-QSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPE 187 + H + I +RD+KLEN LLD + + + DFG SK V ++ GT Y+AP+ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSN--GHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 188 VLLRQEYDG--KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 + +R G K D WS GV +Y +L GA PF E + +RIL + P + Sbjct: 231 I-VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE- 288 Query: 246 RISPECCHLISRIFVADPATRISIP-----EIKTHSWFLK 280 +S LI R+ + DP R+ EIK H +F K Sbjct: 289 -MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >3LM0-A nrPDB Length = 327 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 84/290 (28%), Positives = 134/290 (46%), Gaps = 16/290 (5%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREI-INHRSLRHPNIVRF 81 K++G G F V R K T + A K+++ RG + EI + + P ++ Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 82 KEVILTPTHLAIIMEYASGGELYERICN---AGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 EV + + +I+EYA+GGE++ +C A SE++ +Q+L GV Y H I Sbjct: 95 HEVYENTSEIILILEYAAGGEIFS-LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIV 153 Query: 139 HRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD-- 195 H DLK +N LL P +KI DFG S+ + + +GTP Y+APE+L YD Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL---NYDPI 210 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 D+W+ G+ Y++L PF + Y Q ++V YS +S I Sbjct: 211 TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQ--VNVDYSEETFSSVSQLATDFI 268 Query: 256 SRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQS 305 + V +P R + +HSW + +L + T S Q + ++S Sbjct: 269 QSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRS 318 >4X7Q-B nrPDB Length = 312 Score = 110 bits (276), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 85/280 (30%), Positives = 127/280 (45%), Gaps = 30/280 (10%) Query: 28 IGSGNFGVARLMRDKLTKEL-VAVKYIERG---------DKIDENVQREIINHRSLR--H 75 +G G FG +LT L VA+K I R D + ++ ++ H Sbjct: 39 LGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGH 97 Query: 76 PNIVRFKEVILTPTHLAIIMEYA-SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 P ++R + T +++E +L++ I G E +R FF Q+++ + +CHS Sbjct: 98 PGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHS 157 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQE 193 + HRD+K EN L+D K+ DFG ++LH +P + GT Y PE + R + Sbjct: 158 RGVVHRDIKDENILIDLRRG-CAKLIDFG--SGALLHDEPYTDFDGTRVYSPPEWISRHQ 214 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y A VWS G+ LY M+ G PFE RD Q IL + P +SP+CC Sbjct: 215 YHALPATVWSLGILLYDMVCGDIPFE-----RD-----QEILEAELHFP--AHVSPDCCA 262 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTG 293 LI R P++R S+ EI W +N S G Sbjct: 263 LIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGG 302 >2WTK-C nrPDB Length = 305 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 77/234 (32%), Positives = 119/234 (50%), Gaps = 21/234 (8%) Query: 60 DENVQREIINHRSLRHPNIVRFKEVILT--PTHLAIIMEYASGG--ELYERICNAGRFSE 115 + NV++EI R LRH N+++ +V+ + ++MEY G E+ + + RF Sbjct: 50 EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPV 108 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--- 172 +A +F QL+ G+ Y HS I H+D+K N LL + LKI G +++ LH Sbjct: 109 CQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLL--TTGGTLKISALGVAEA--LHPFAA 164 Query: 173 --QPKSTVGTPAYIAPEVLLRQE-YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 +++ G+PA+ PE+ + + G D+WS GVTLY + G YPFE + K Sbjct: 165 DDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYK 220 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLP 283 + I Y+IP D P L+ + +PA R SI +I+ HSWF K P Sbjct: 221 LFENIGKGSYAIPGD--CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 >4APC-A nrPDB Length = 350 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 79/274 (28%), Positives = 143/274 (52%), Gaps = 24/274 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHRSLRHP 76 ++Y ++ IG G+FG A L++ +K I K E +RE+ +++HP Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR---FSEDEARFFFQQLLSGVSYCH 133 NIV+++E L I+M+Y GG+L++RI NA + F ED+ +F Q+ + + H Sbjct: 84 NIVQYRESFEENGSLYIVMDYCEGGDLFKRI-NAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 134 SMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEV 188 +I HRD+K +N L DG+ +++ DFG ++ VL+S ++ +GTP Y++PE+ Sbjct: 143 DRKILHRDIKSQNIFLTKDGT----VQLGDFGIAR--VLNSTVELARACIGTPYYLSPEI 196 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + Y+ K +D+W+ G LY + + F E + + +I+S + P + S Sbjct: 197 CENKPYNNK-SDIWALGCVLYELCTLKHAF----EAGSMKNLVLKIISGSFP-PVSLHYS 250 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 + L+S++F +P R S+ I + K + Sbjct: 251 YDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRI 284 >4XBR-A nrPDB Length = 366 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 143/278 (51%), Gaps = 18/278 (6%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRF 81 +F+K IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 98 NFIK-IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEM 156 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD Sbjct: 157 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 142 LKLENTLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 +K ++ LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G Sbjct: 216 IKSDSILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPE 270 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 D+WS G+ + M+ G P+ + E P K I+ L + + + ++SP + R+ Sbjct: 271 VDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPR--LKNLHKVSPSLKGFLDRL 327 Query: 259 FVADPATRISIPEIKTHSWFLKNLP----ADLMNESNT 292 V DPA R + E+ H + K P LM ++ T Sbjct: 328 LVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT 365 >2Y7J-A nrPDB Length = 365 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 80/274 (29%), Positives = 131/274 (47%), Gaps = 21/274 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---------RGDKIDENVQREI-INH 70 +YD IG G V R + T AVK +E + +++ E +RE I Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + HP+I+ + + + + ++ + GEL++ + SE E R + LL VS Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 + H+ I HRDLK EN LLD + ++++ DFG+S + + GTP Y+APE+ L Sbjct: 215 FLHANNIVHRDLKPENILLDDN--MQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEI-L 271 Query: 191 RQEYD------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 + D GK D+W+CGV L+ +L G+ PF + R ++ ++S P+ Sbjct: 272 KCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG--QYQFSSPEW 329 Query: 245 IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S LISR+ DP R++ + H +F Sbjct: 330 DDRSSTVKDLISRLLQVDPEARLTAEQALQHPFF 363 >6E2O-A nrPDB Length = 295 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 78/245 (31%), Positives = 123/245 (50%), Gaps = 10/245 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYI-ERGDKIDENVQREIINHRSLRHPNIVRFKEVIL 86 +G G +G+ RD + +A+K I ER + + + EI H+ L+H NIV++ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS 89 Query: 87 TPTHLAIIMEYASGGELYERI-CNAGRFSEDEAR--FFFQQLLSGVSYCHSMQICHRDLK 143 + I ME GG L + G ++E F+ +Q+L G+ Y H QI HRD+K Sbjct: 90 ENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIK 149 Query: 144 LENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLRQEYD-GKIADV 201 +N L++ + + LKI DFG SK + ++ ++ GT Y+APE++ + GK AD+ Sbjct: 150 GDNVLIN-TYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 208 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVA 261 WS G T+ M G PF + EP+ + + V IP+ +S E I + F Sbjct: 209 WSLGCTIIEMATGKPPFYELGEPQAAMFKVG-MFKVHPEIPES--MSAEAKAFILKCFEP 265 Query: 262 DPATR 266 DP R Sbjct: 266 DPDKR 270 >4JDH-A nrPDB Length = 346 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 143/278 (51%), Gaps = 18/278 (6%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRF 81 +F+K IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 78 NFIK-IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEM 136 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 142 LKLENTLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 +K ++ LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G Sbjct: 196 IKSDSILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPE 250 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 D+WS G+ + M+ G P+ + E P K I+ L + + + ++SP + R+ Sbjct: 251 VDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPR--LKNLHKVSPSLKGFLDRL 307 Query: 259 FVADPATRISIPEIKTHSWFLKNLP----ADLMNESNT 292 V DPA R + E+ H + K P LM ++ T Sbjct: 308 LVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT 345 >2Q0N-A nrPDB Length = 301 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 143/278 (51%), Gaps = 18/278 (6%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRF 81 +F+K IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 33 NFIK-IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEM 91 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 142 LKLENTLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 +K ++ LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G Sbjct: 151 IKSDSILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPE 205 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 D+WS G+ + M+ G P+ + E P K I+ L + + + ++SP + R+ Sbjct: 206 VDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPR--LKNLHKVSPSLKGFLDRL 262 Query: 259 FVADPATRISIPEIKTHSWFLKNLP----ADLMNESNT 292 V DPA R + E+ H + K P LM ++ T Sbjct: 263 LVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT 300 >4EQM-A nrPDB Length = 294 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 71/206 (34%), Positives = 102/206 (49%), Gaps = 9/206 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI----ERGDKIDENVQREIINHRSLR 74 ++RY V +G G L D + VA+K I ++ + +RE+ N L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NIV +V ++MEY G L E I + G S D A F Q+L G+ + H Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHD 129 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQ 192 M+I HRD+K +N L+D + LKI DFG +K S +Q +GT Y +PE + Sbjct: 130 MRIVHRDIKPQNILIDSNKT--LKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAKG 186 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPF 218 E + D++S G+ LY MLVG PF Sbjct: 187 EATDECTDIYSIGIVLYEMLVGEPPF 212 >4FIE-A nrPDB Length = 423 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 143/278 (51%), Gaps = 18/278 (6%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRF 81 +F+K IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 155 NFIK-IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEM 213 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD Sbjct: 214 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 142 LKLENTLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 +K ++ LL DG R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G Sbjct: 273 IKSDSILLTHDG----RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPE 327 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 D+WS G+ + M+ G P+ + E P K I+ L + + + ++SP + R+ Sbjct: 328 VDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPR--LKNLHKVSPSLKGFLDRL 384 Query: 259 FVADPATRISIPEIKTHSWFLKNLP----ADLMNESNT 292 V DPA R + E+ H + K P LM ++ T Sbjct: 385 LVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT 422 >6DC0-A nrPDB Length = 292 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 104/208 (50%), Gaps = 13/208 (6%) Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NI EVIL T + E G+++ + + R E+EA F+Q++S V++CH Sbjct: 57 HSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 115 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVL-L 190 I DLKL + +L++ + ++ + + G PAY++PE+L Sbjct: 116 SAIVLGDLKLRKFVFSTEERTQLRLESL--EDTHIMKGEDDALSDKHGCPAYVSPEILNT 173 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Y GK ADVWS GV LY +LVG YPF D D +I ++ IP+ ISP+ Sbjct: 174 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDS----DPSALFSKIRRGQFCIPE--HISPK 227 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWF 278 LI + +P+ R++ PEI H WF Sbjct: 228 ARCLIRSLLRREPSERLTAPEILLHPWF 255 >4KS7-A nrPDB Length = 292 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 80/266 (30%), Positives = 139/266 (52%), Gaps = 22/266 (8%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFK 82 +VK IG G+ G+ L R+K + VAVK ++ R + E + E++ R +H N+V Sbjct: 28 YVK-IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMY 86 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 + L L ++ME+ GG L + I + R +E++ + +L ++Y H+ + HRD+ Sbjct: 87 KSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 143 KLENTL--LDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIA 199 K ++ L LDG R+K+ DFG+ ++ S + KS VGTP ++APEV+ R Y ++ Sbjct: 146 KSDSILLTLDG----RVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEV- 200 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI----RISPECCHLI 255 D+WS G+ + M+ D E P +Q + ++ S P + ++SP + Sbjct: 201 DIWSLGIMVIEMV-------DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFL 253 Query: 256 SRIFVADPATRISIPEIKTHSWFLKN 281 R+ V DP R + E+ H + L+ Sbjct: 254 ERMLVRDPQERATAQELLDHPFLLQT 279 >5CEK-A nrPDB Length = 263 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 104/208 (50%), Gaps = 13/208 (6%) Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NI EVIL T + E G+++ + + R E+EA F+Q++S V++CH Sbjct: 60 HSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 118 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVL-L 190 I DLKL + +L++ + ++ + + G PAY++PE+L Sbjct: 119 SAIVLGDLKLRKFVFSTEERTQLRLESL--EDTHIMKGEDDALSDKHGCPAYVSPEILNT 176 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Y GK ADVWS GV LY +LVG YPF D D +I ++ IP+ ISP+ Sbjct: 177 TGTYSGKAADVWSLGVMLYTLLVGRYPFHD----SDPSALFSKIRRGQFCIPEH--ISPK 230 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWF 278 LI + +P+ R++ PEI H WF Sbjct: 231 ARCLIRSLLRREPSERLTAPEILLHPWF 258 >6BXI-A nrPDB Length = 333 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 57/304 (18%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN---- 77 ++ +K IG G FG RL++ K T + A+K + + D +++ I R + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V+ +L +IME+ GG++ + +E+E +F+ + + + H + Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF 127 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKS-----------SVLHSQPK----------- 175 HRD+K +N LLD +K+ DFG ++ HS P Sbjct: 128 IHRDIKPDNLLLDSK--GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 176 --------------STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF--E 219 STVGTP YIAPEV ++ Y+ K+ D WS GV +Y ML+G PF E Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSE 244 Query: 220 DPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHLISRIFVADPATRISIP---EIKT 274 P+E T +++++ K ++ P ++ IS + LI R F + RI P EIK+ Sbjct: 245 TPQE------TYKKVMNWKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGAPGVEEIKS 297 Query: 275 HSWF 278 +S+F Sbjct: 298 NSFF 301 >1PHK-A nrPDB Length = 298 Score = 104 bits (260), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 121/269 (44%), Gaps = 24/269 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYI----------ERGDKIDENVQREI-INHRSLRHP 76 +G G V R K T + AVK I E ++ E +E+ I + HP Sbjct: 25 LGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHP 84 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 NI++ K+ T T ++ + GEL++ + SE E R + LL + H + Sbjct: 85 NIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKLN 144 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD- 195 I HRDLK EN LLD +K+ DFG+S + + GTP+Y+APE++ D Sbjct: 145 IVHRDLKPENILLDDD--MNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDN 202 Query: 196 ----GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISP 249 GK D+WS GV +Y +L G+ PF R ++ I+S Y P+ S Sbjct: 203 HPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLMLRMIMSGNYQFGSPEWDDYSD 258 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWF 278 L+SR V P R + E H +F Sbjct: 259 TVKDLVSRFLVVQPQKRYTAEEALAHPFF 287 >3HKO-A nrPDB Length = 345 Score = 104 bits (259), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 135/311 (43%), Gaps = 58/311 (18%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD------KIDENVQREIINHRSLR 74 +Y IG G++GV R+ + T+ + A+K + + K E ++ E+ + L Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYER--------------------ICNAGRFS 114 HPNI R EV ++ ++ME GG L ++ IC + Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 115 ED----------EARFFFQ----------QLLSGVSYCHSMQICHRDLKLENTLLDGSPA 154 E+ E+ F Q Q+ S + Y H+ ICHRD+K EN L + + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 155 PRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVL-LRQEYDGKIADVWSCGVTL 208 +K+ DFG SK ++ + + GTP ++APEVL E G D WS GV L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 209 YVMLVGAYPFEDPEEPRDYRKTIQRILSVK--YSIPDDIRISPECCHLISRIFVADPATR 266 +++L+GA PF + TI ++L+ K + P+ +SP L+S + + R Sbjct: 267 HLLLMGAVPFPGVNDA----DTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDER 322 Query: 267 ISIPEIKTHSW 277 H W Sbjct: 323 FDAMRALQHPW 333 >5LOH-A nrPDB Length = 341 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 77/271 (28%), Positives = 128/271 (47%), Gaps = 21/271 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----RH 75 + + VK I G FG L + +L AVK +++ D I++N+ ++ R + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P IV + + ++ ++MEY GG++ + G F E+ A + ++ + Y H Sbjct: 94 PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 153 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-------QPKSTVGTPAYIAPEV 188 I HRDLK +N L+ S +K+ DFG SK ++ ++ GTP Y+APE+ Sbjct: 154 GIIHRDLKPDNMLI--SNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPEL 211 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD-DIRI 247 LL + + G D W+ GV L+ L G PF D E P ++ Q IL P+ + ++ Sbjct: 212 LLGRAH-GPAVDWWALGVCLFEFLTGIPPFND-ETP---QQVFQNILKRDIPWPEGEEKL 266 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWF 278 S + + D R + E+K H F Sbjct: 267 SDNAQSAVEILLTIDDTKRAGMKELKRHPLF 297 >6CQF-A nrPDB Length = 297 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 62/193 (32%), Positives = 106/193 (54%), Gaps = 8/193 (4%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPNI 78 D YD ++ +G G +G RDK++ +LVA+K ++ D +Q+EI+ ++ RH NI Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANI 75 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V + L L I ME+ G L + G SE + + +++L G++Y HS + Sbjct: 76 VAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKI 135 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE---VLLRQEY 194 HRD+K N L++ A +++ DFG S ++ + +GTP ++APE V L+ Y Sbjct: 136 HRDIKGANILIN--DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 195 DGKIADVWSCGVT 207 + ++ D+WS G+T Sbjct: 194 N-ELCDIWSLGIT 205 >3FXW-A nrPDB Length = 336 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 83/275 (30%), Positives = 132/275 (48%), Gaps = 17/275 (6%) Query: 19 SDRYDFVKDI-GSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHP 76 +D Y K + G G G + T + A+K + K ++E+ +H ++ P Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK----ARQEVDHHWQASGGP 82 Query: 77 NIVRFKEVILTPTH----LAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVS 130 +IV +V H L IIME GGEL+ RI G F+E EA + + + + Sbjct: 83 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 131 YCHSMQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 + HS I HRD+K EN L LK+ DFG++K + ++ ++ TP Y+APEVL Sbjct: 143 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCYTPYYVAPEVL 201 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD--IRI 247 ++YD K D+WS GV +Y++L G PF +RI +Y P+ + Sbjct: 202 GPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEV 260 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 S + LI + DP R++I + H W +++ Sbjct: 261 SEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSM 295 >3PPZ-A nrPDB Length = 309 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 87/261 (33%), Positives = 127/261 (48%), Gaps = 32/261 (12%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNIVRFKEV 84 IG+G+FG R + VAVK + D E V RE+ + LRHPNIV F Sbjct: 45 IGAGSFGTVH--RAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGA 102 Query: 85 ILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQ--LLSGVSYCHSMQ--ICH 139 + P +L+I+ EY S G LY + +G R DE R + G++Y H+ I H Sbjct: 103 VTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVH 162 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 RDLK N L+D +K+CDFG S+ S+ L S KS GTP ++APEV LR E Sbjct: 163 RDLKSPNLLVDKKYT--VKVCDFGLSRLKASTFLSS--KSAAGTPEWMAPEV-LRDEPSN 217 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS-----IPDDIRISPEC 251 + +DV+S GV L+ + P+ + Q + +V + IP + ++P+ Sbjct: 218 EKSDVYSFGVILWELATLQQPWGN-------LNPAQVVAAVGFKCKRLEIPRN--LNPQV 268 Query: 252 CHLISRIFVADPATRISIPEI 272 +I + +P R S I Sbjct: 269 AAIIEGCWTNEPWKRPSFATI 289 >4CRS-A nrPDB Length = 341 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/265 (31%), Positives = 129/265 (48%), Gaps = 31/265 (11%) Query: 31 GNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR-------SLRHPNIVRFKE 83 G+FG L K T E+ A+K +++GD + + ++ + S+RHP +V Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 82 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 T H+ +MEYA+GG+L I + FSE A F+ ++ G+ Y H +I +RDLK Sbjct: 83 CFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLK 141 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIADVW 202 L+N LLD +KI DFG K + + ST GTP ++APEVL Y + D W Sbjct: 142 LDNLLLDTEGF--VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYT-RAVDWW 198 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR----ISPECCHLISRI 258 GV +Y MLVG PF +E + + D++R +S E ++ R+ Sbjct: 199 GLGVLIYEMLVGESPFPGDDEEEVFDSIVN----------DEVRYPRFLSTEAISIMRRL 248 Query: 259 FVADPATRISIPE-----IKTHSWF 278 +P R+ E +K H +F Sbjct: 249 LRRNPERRLGASEKDAEDVKKHPFF 273 >5TUR-A nrPDB Length = 404 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 85/277 (30%), Positives = 126/277 (45%), Gaps = 42/277 (15%) Query: 21 RYDFVKDIGSGNFGVAR---LMRDKLTKELVAVKYIERGDKIDE--------NVQREII- 68 +Y +GSG FG + D L VA+K++E+ D+I + V E++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEK-DRISDWGELPNGTRVPMEVVL 183 Query: 69 -NHRSLRHPNIVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLL 126 S ++R + P +I+E +L++ I G E+ AR FF Q+L Sbjct: 184 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTP 181 V +CH+ + HRD+K EN L+D + LK+ DFG ++L K TV GT Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG--SGALL----KDTVYTDFDGTR 296 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 Y PE + Y G+ A VWS G+ LY M+ G PFE EE ++ + Sbjct: 297 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------IIRGQV 344 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 R+S EC HLI P+ R + EI+ H W Sbjct: 345 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 381 >4RC3-A nrPDB Length = 289 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 86/269 (31%), Positives = 126/269 (46%), Gaps = 42/269 (15%) Query: 28 IGSGNFG-VARLMR--DKLTKELVAVKYIERGDKIDE--------NVQREII--NHRSLR 74 +GSG FG V +R D L VA+K++E+ D+I + V E++ S Sbjct: 20 LGSGGFGSVYSGIRVSDNLP---VAIKHVEK-DRISDWGELPNGTRVPMEVVLLKKVSSG 75 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 ++R + P +I+E +L++ I G E+ AR FF Q+L V +CH Sbjct: 76 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 135 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTPAYIAPEV 188 + + HRD+K EN L+D + LK+ DFG ++L K TV GT Y PE Sbjct: 136 NCGVLHRDIKDENILIDLNRG-ELKLIDFG--SGALL----KDTVYTDFDGTRVYSPPEW 188 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + Y G+ A VWS G+ LY M+ G PFE EE ++ + R+S Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------IIRGQVFFRQRVS 236 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 EC HLI P+ R + EI+ H W Sbjct: 237 SECQHLIRWCLALRPSDRPTFEEIQNHPW 265 >3BGP-A nrPDB Length = 333 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/269 (31%), Positives = 126/269 (46%), Gaps = 42/269 (15%) Query: 28 IGSGNFG-VARLMR--DKLTKELVAVKYIERGDKIDE--------NVQREII--NHRSLR 74 +GSG FG V +R D L VA+K++E+ D+I + V E++ S Sbjct: 64 LGSGGFGSVYSGIRVSDNLP---VAIKHVEK-DRISDWGELPNGTRVPMEVVLLKKVSSG 119 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 ++R + P +I+E +L++ I G E+ AR FF Q+L V +CH Sbjct: 120 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 179 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-----GTPAYIAPEV 188 + + HRD+K EN L+D + LK+ DFG ++L K TV GT Y PE Sbjct: 180 NCGVLHRDIKDENILIDLNRG-ELKLIDFG--SGALL----KDTVYTDFDGTRVYSPPEW 232 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + Y G+ A VWS G+ LY M+ G PFE EE ++ + R+S Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------IIRGQVFFRQRVS 280 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 EC HLI P+ R + EI+ H W Sbjct: 281 SECQHLIRWCLALRPSDRPTFEEIQNHPW 309 >4BGQ-A nrPDB Length = 304 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 71/224 (31%), Positives = 111/224 (49%), Gaps = 13/224 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHP 76 ++++ + +G G +GV R K T E+VA+K E +++ E RE+ R+L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQE 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 NIV KE L ++ EY EL E + N ++ + + QL+ + +CH Sbjct: 72 NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCHK 129 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQ 192 I HRD+K EN L+ + LK+CDFG+++ S ++ V T Y +PE+LL Sbjct: 130 NDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS 236 Y GK D+WS G L + G P E D TIQ++L Sbjct: 188 PY-GKSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLG 229 >1TKI-A nrPDB Length = 321 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 68/268 (25%), Positives = 125/268 (46%), Gaps = 12/268 (4%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 ++Y +D+G G FG+ + +K+ K+++ V++EI RH NI+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNIL 64 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 E + L +I E+ SG +++ERI +A +E E + Q+ + + HS I Sbjct: 65 HLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIG 124 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD--G 196 H D++ EN + + +KI +FG ++ + P Y APEV ++D Sbjct: 125 HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV---HQHDVVS 181 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECCHL 254 D+WS G +YV+L G PF ++ I+ I++ +Y+ ++ IS E Sbjct: 182 TATDMWSLGTLVYVLLSGINPF----LAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 237 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNL 282 + R+ V + +R++ E H W + + Sbjct: 238 VDRLLVKERKSRMTASEALQHPWLKQKI 265 >4OTD-A nrPDB Length = 341 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 128/262 (48%), Gaps = 26/262 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR-------SLR 74 + F+ +G G+FG L + + EL A+K +++GD + + ++ + S Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAG 73 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HP +V TP H+ +MEY++GG+L I ++ FSE A F+ ++ G+ + H Sbjct: 74 HPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSACVVLGLQFLHE 132 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQE 193 +I +RDLKL+N LL +KI DFG K + + ST GTP ++APEVL Sbjct: 133 HKIVYRDLKLDNLLL--DTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 190 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR----ISP 249 Y + D W GV LY MLVG PF +E + + D++R +S Sbjct: 191 YT-RAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN----------DEVRYPRFLSA 239 Query: 250 ECCHLISRIFVADPATRISIPE 271 E ++ R+ +P R+ E Sbjct: 240 EAIGIMRRLLRRNPERRLGSSE 261 >2F57-A nrPDB Length = 317 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 138/266 (51%), Gaps = 23/266 (8%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRF 81 +F+K IG G+ G+ + +K T + VAVK ++ R + E + E++ R H N+V Sbjct: 49 NFIK-IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDM 107 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L L ++ME+ GG L + I R +E++ +L +SY H+ + HRD Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 142 LKLENTLL--DGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 +K ++ LL DG R+K+ DFG+ ++ S + KS VGTP ++APEV+ R Y G Sbjct: 167 IKSDSILLTSDG----RIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTE 221 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI----RISPECCHL 254 D+WS G+ + M+ G P+ + EP +Q + ++ S+P + ++S Sbjct: 222 VDIWSLGIMVIEMIDGEPPYFN--EP-----PLQAMRRIRDSLPPRVKDLHKVSSVLRGF 274 Query: 255 ISRIFVADPATRISIPEIKTHSWFLK 280 + + V +P+ R + E+ H FLK Sbjct: 275 LDLMLVREPSQRATAQELLGHP-FLK 299 >3DLS-A nrPDB Length = 335 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 76/269 (28%), Positives = 123/269 (45%), Gaps = 24/269 (8%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---------NVQREIIN 69 S +Y + +GSG FG DK + V VK+I++ +++ V EI Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIME-YASGGELYERICNAGRFSEDEARFFFQQLLSG 128 + H NI++ ++ ++ME + SG +L+ I R E A + F+QL+S Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 V Y I HRD+K EN ++ + +K+ DFG + + GT Y APEV Sbjct: 143 VGYLRLKDIIHRDIKDENIVI--AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEV 200 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 L+ Y G ++WS GVTLY ++ PF + EE +V+ +I +S Sbjct: 201 LMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEE------------TVEAAIHPPYLVS 248 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSW 277 E L+S + P R ++ ++ T W Sbjct: 249 KELMSLVSGLLQPVPERRTTLEKLVTDPW 277 >5VO2-A nrPDB Length = 300 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 85/255 (33%), Positives = 122/255 (47%), Gaps = 29/255 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +GSG G L R E VAVK K+ + + +I + R L+HPNI+ FK V Sbjct: 20 VGSGAQGAVFLGR--FHGEEVAVK------KVRDLKETDIKHLRKLKHPNIITFKGVCTQ 71 Query: 88 PTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLEN 146 I+ME+ + G+LYE + AGR + + + G++Y H +I HRDLK N Sbjct: 72 APCYCILMEFCAQGQLYE-VLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 130 Query: 147 TLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGV 206 L+ +KI DFG SK S S GT A++APEV +R E + D+WS GV Sbjct: 131 MLITYDDV--VKISDFGTSKELSDKSTKMSFAGTVAWMAPEV-IRNEPVSEKVDIWSFGV 187 Query: 207 TLYVMLVGAYPFEDPEEPRDYRKTIQRI------LSVKYSIPDDIRISPECCHLISRIFV 260 L+ +L G P++D D I + L V S PD +I L+ + + Sbjct: 188 VLWELLTGEIPYKD----VDSSAIIWGVGSNSLHLPVPSSCPDGFKI------LLRQCWN 237 Query: 261 ADPATRISIPEIKTH 275 + P R S +I H Sbjct: 238 SKPRNRPSFRQILLH 252 >5J5T-A nrPDB Length = 370 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/274 (28%), Positives = 128/274 (46%), Gaps = 11/274 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPNIV 79 ++ ++ IGSG +G R+ T EL A+K I E G+ VQ+EII + +HPNIV Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF-AVVQQEIIMMKDCKHPNIV 64 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + L L I ME+ GG L + G SE + + ++ L G+ Y HS H Sbjct: 65 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 124 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLRQEYDG-- 196 RD+K N LL + +K+ DFG S + ++ K+ +GTP ++APEV + G Sbjct: 125 RDIKGANILLTDN--GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRD-YRKTIQRILSVKYSIPDDIRISPECCHLI 255 ++ D+W+ G+T + P D R + T K + D ++ S H + Sbjct: 183 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPK--LKDKMKWSNSFHHFV 240 Query: 256 SRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 +P R + ++ H + ++L L E Sbjct: 241 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE 274 >5L2Q-C nrPDB Length = 320 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 59/162 (36%), Positives = 86/162 (53%), Gaps = 6/162 (3%) Query: 112 RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 171 R SE E F ++ V H I HRDLKL N +L+ R+ I +F K V Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLGKHLVSE 207 Query: 172 SQP-KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT 230 K G+PAYI+P+VL + Y GK +D+W+ GV L+ ML G +PF D +RK Sbjct: 208 GDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRK- 266 Query: 231 IQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 I + +Y+IP+D R+S LI ++ V DP R++ ++ Sbjct: 267 ---IKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADV 305 >6FD3-A nrPDB Length = 300 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 67/207 (32%), Positives = 106/207 (51%), Gaps = 12/207 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIV 79 +Y + IG G G D T + VA+K + + E + EI+ R ++PNIV Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIV 82 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + + L L ++MEY +GG L + + E + ++ L + + HS Q+ H Sbjct: 83 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIH 141 Query: 140 RDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQEYDG 196 RD+K +N LL DGS +K+ DFG+ +ST VGTP ++APEV+ R+ Y Sbjct: 142 RDIKSDNILLGMDGS----VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 197 Query: 197 KIADVWSCGVTLYVMLVGAYPF--EDP 221 K+ D+WS G+ M+ G P+ E+P Sbjct: 198 KV-DIWSLGIMAIEMVEGEPPYLNENP 223 >3Q53-A nrPDB Length = 306 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 66/207 (31%), Positives = 106/207 (51%), Gaps = 12/207 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIV 79 +Y + IG G G D T + VA++ + + E + EI+ R ++PNIV Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV 81 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + + L L ++MEY +GG L + + E + ++ L + + HS Q+ H Sbjct: 82 NYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIH 140 Query: 140 RDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQEYDG 196 RD+K +N LL DGS +K+ DFG+ +ST VGTP ++APEV+ R+ Y Sbjct: 141 RDIKSDNILLGMDGS----VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 196 Query: 197 KIADVWSCGVTLYVMLVGAYPF--EDP 221 K+ D+WS G+ M+ G P+ E+P Sbjct: 197 KV-DIWSLGIMAIEMIEGEPPYLNENP 222 >1U5R-A nrPDB Length = 348 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 66/192 (34%), Positives = 99/192 (51%), Gaps = 17/192 (8%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVR 80 +++IG G+FG RD E+VA+K + K ++II + LRHPN ++ Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 81 FKEVILTPTHLAIIMEY--ASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 ++ L ++MEY S +L E + E E L G++Y HS + Sbjct: 119 YRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 176 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---RQEYD 195 HRD+K N LL S +K+ DFG S+ + + S VGTP ++APEV+L +YD Sbjct: 177 HRDVKAGNILL--SEPGLVKLGDFG---SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 231 Query: 196 GKIADVWSCGVT 207 GK+ DVWS G+T Sbjct: 232 GKV-DVWSLGIT 242 >2GCD-A nrPDB Length = 309 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 66/192 (34%), Positives = 99/192 (51%), Gaps = 17/192 (8%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVR 80 +++IG G+FG RD E+VA+K + K ++II + LRHPN ++ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 81 FKEVILTPTHLAIIMEY--ASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 ++ L ++MEY S +L E + E E L G++Y HS + Sbjct: 80 YRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSHNMI 137 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL---RQEYD 195 HRD+K N LL S +K+ DFG S+ + + S VGTP ++APEV+L +YD Sbjct: 138 HRDVKAGNILL--SEPGLVKLGDFG---SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 192 Query: 196 GKIADVWSCGVT 207 GK+ DVWS G+T Sbjct: 193 GKV-DVWSLGIT 203 >2BPM-A nrPDB Length = 309 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 69/203 (33%), Positives = 106/203 (52%), Gaps = 13/203 (6%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSL 73 D + + V+ IG G +GV R+KLT E+VA+K I R D E V REI + L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKEL 63 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVS 130 HPNIV+ +VI T L ++ E+ + ++ +A + + + QLL G++ Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVL 189 +CHS ++ HRDLK +N L++ A +K+ DFG +++ V V T Y APE+L Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 190 LRQEYDGKIADVWSCGVTLYVML 212 L +Y D+WS G M+ Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMV 202 >2XNP-A nrPDB Length = 279 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 83/272 (30%), Positives = 132/272 (48%), Gaps = 29/272 (10%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRH 75 ++ Y+ + IG+G++G + +R K +++ K ++ G + Q E+ R L+H Sbjct: 5 AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 76 PNIVRFKEVIL--TPTHLAIIMEYASGGELYERICNAGR----FSEDEARFFFQQLLSGV 129 PNIVR+ + I+ T T L I+MEY GG+L I + E+ QL + Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 130 SYCH-----SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH---SQPKSTVGTP 181 CH + HRDLK N LDG +K+ DFG ++ +L+ S K+ VGTP Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQ--NVKLGDFGLAR--ILNHDTSFAKTFVGTP 180 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY-S 240 Y++PE + R Y+ K +D+WS G LY + PF + ++ +I K+ Sbjct: 181 YYMSPEQMNRMSYNEK-SDIWSLGCLLYELCALMPPFTAFSQ----KELAGKIREGKFRR 235 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEI 272 IP R S E +I+R+ R S+ EI Sbjct: 236 IP--YRYSDELNEIITRMLNLKDYHRPSVEEI 265 >3C51-A nrPDB Length = 543 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 123/267 (46%), Gaps = 23/267 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN------VQREIINHRSLRHPNIVRF 81 +G G FG + K T +L A K + + V+++I+ R IV Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF--IVSL 250 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGR----FSEDEARFFFQQLLSGVSYCHSMQI 137 T T L ++M +GG++ I N F E A F+ Q++SG+ + H I Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYS-KSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 +RDLK EN LLD ++I D G + + ++ K GTP ++APE+LL +EYD Sbjct: 311 IYRDLKPENVLLDDD--GNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDF 368 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 + D ++ GVTLY M+ PF E + ++ QR+L + PD + SP Sbjct: 369 SV-DYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD--KFSPASKDFCE 425 Query: 257 RIFVADPATRISIPE-----IKTHSWF 278 + DP R+ + ++TH F Sbjct: 426 ALLQKDPEKRLGFRDGSCDGLRTHPLF 452 >2UV2-A nrPDB Length = 325 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 68/206 (33%), Positives = 109/206 (52%), Gaps = 15/206 (7%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLR 74 ++ D ++ + ++G G FG ++K T L A K I+ + ++ E+ EI S Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCD 92 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCH 133 HPNIV+ + +L I++E+ +GG + + R +E + + +Q L ++Y H Sbjct: 93 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 134 SMQICHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLL 190 +I HRDLK N L LDG +K+ DFG S + Q + S +GTP ++APEV++ Sbjct: 153 DNKIIHRDLKAGNILFTLDGD----IKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM 208 Query: 191 RQE-----YDGKIADVWSCGVTLYVM 211 + YD K ADVWS G+TL M Sbjct: 209 CETSKDRPYDYK-ADVWSLGITLIEM 233 >3M42-A nrPDB Length = 299 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 77/263 (29%), Positives = 123/263 (46%), Gaps = 34/263 (12%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR----FKE 83 +G G G + +K T+E A+K ++ K V+ ++ R+ + P+IVR ++ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIVRIVDVYEN 82 Query: 84 VILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 + L I+ME GGEL+ RI + G F+E EA + + + Y HS+ I HRD Sbjct: 83 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 142 Query: 142 LKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 +K EN L P LK+ DFG++ K T G ++YD K D Sbjct: 143 VKPENLLYTSKRPNAILKLTDFGFA---------KETTG------------EKYD-KSCD 180 Query: 201 VWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 +WS GV +Y++L G PF KT R+ ++ P+ +S E LI + Sbjct: 181 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 240 Query: 259 FVADPATRISIPEIKTHSWFLKN 281 +P R++I E H W +++ Sbjct: 241 LKTEPTQRMTITEFMNHPWIMQS 263 >4QMW-A nrPDB Length = 310 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 137/292 (46%), Gaps = 26/292 (8%) Query: 1 MDRAPVTTGPLDMPIMHD-----SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE- 54 M +PV +G +P M + + + ++ IG G+FG D T+++VA+K I+ Sbjct: 8 MAHSPVQSG---LPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL 64 Query: 55 -RGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRF 113 + E++Q+EI P + ++ L T L IIMEY GG + + G Sbjct: 65 EEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALD-LLEPGPL 123 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 E + +++L G+ Y HS + HRD+K N LL S +K+ DFG + + +Q Sbjct: 124 DETQIATILREILKGLDYLHSEKKIHRDIKAANVLL--SEHGEVKLADFGVA-GQLTDTQ 180 Query: 174 PK--STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 K + VGTP ++APEV+ + YD K AD+WS G+T + G E P + Sbjct: 181 IKRNTFVGTPFWMAPEVIKQSAYDSK-ADIWSLGITAIELARG-------EPPHSELHPM 232 Query: 232 QRILSVKYSIPDDIR--ISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 + + + + P + S + +P+ R + E+ H + L+N Sbjct: 233 KVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 284 >4UY9-A nrPDB Length = 323 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 74/206 (35%), Positives = 105/206 (50%), Gaps = 21/206 (10%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID-----ENVQREIINHRSLRHPNIVRFK 82 IG G FG ++ R + VAVK D ENV++E L+HPNI+ + Sbjct: 17 IGIGGFG--KVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS---MQICH 139 V L +L ++ME+A GG L R+ + R D + Q+ G++Y H + I H Sbjct: 75 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 133 Query: 140 RDLKLENTLL-----DGSPAPR-LKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQ 192 RDLK N L+ +G + + LKI DFG ++ H K S GT A++APEV +R Sbjct: 134 RDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGTYAWMAPEV-IRA 190 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPF 218 K +DVWS GV L+ +L G PF Sbjct: 191 SMFSKGSDVWSYGVLLWELLTGEVPF 216 >2XIK-A nrPDB Length = 294 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 71/197 (36%), Positives = 101/197 (51%), Gaps = 9/197 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+FG D TKE+VA+K I+ + E++Q+EI P I R+ Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 86 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L T L IIMEY GG + + G E +++L G+ Y HS + HRD+K Sbjct: 87 LKSTKLWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAA 145 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLLRQEYDGKIADVWS 203 N LL S +K+ DFG + + +Q K + VGTP ++APEV+ + YD K AD+WS Sbjct: 146 NVLL--SEQGDVKLADFGVA-GQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK-ADIWS 201 Query: 204 CGVTLYVMLVGAYPFED 220 G+T + G P D Sbjct: 202 LGITAIELAKGEPPNSD 218 >3GC0-A nrPDB Length = 329 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 74/220 (33%), Positives = 105/220 (47%), Gaps = 15/220 (6%) Query: 7 TTGPLDM-----PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE 61 T GP M P DRY + +G G +G D +T E VA+K I R + +E Sbjct: 16 TQGPGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRI-RLEHEEE 74 Query: 62 NVQ----REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE 117 V RE+ + L+H NI+ K VI L +I EYA +L + + S Sbjct: 75 GVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRV 133 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLL---DGSPAPRLKICDFGYSKS-SVLHSQ 173 + F QL++GV++CHS + HRDLK +N LL D S P LKI DFG +++ + Q Sbjct: 134 IKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQ 193 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV 213 + T Y PE+LL + D+WS ML+ Sbjct: 194 FTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLM 233 >4UYA-A nrPDB Length = 340 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 73/220 (33%), Positives = 107/220 (48%), Gaps = 21/220 (9%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-----ENVQREII 68 P+ +R + + IG+G FG ++ R + VAVK + + D E+V+RE Sbjct: 20 PVHVAFERLELKELIGAGGFG--QVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREAR 77 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 LRHPNI+ + V L HL +++E+A GG L R R + Q+ G Sbjct: 78 LFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARG 136 Query: 129 VSYCHS---MQICHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPK-STV 178 + Y H + I HRDLK N LL D LKI DFG ++ H K +T Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--WHRTTKMATA 194 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 G A++APEV ++ K +D+WS GV L+ +L G P+ Sbjct: 195 GAYAWMAPEV-IKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >3COM-A nrPDB Length = 314 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 100/201 (49%), Gaps = 6/201 (2%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 +D ++ +G G++G K T ++VA+K + + E + +EI + P++V++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEII-KEISIMQQCDSPHVVKY 89 Query: 82 KEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T L I+MEY G + + I +EDE Q L G+ Y H M+ HR Sbjct: 90 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHR 149 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIA 199 D+K N LL+ K+ DFG + ++TV GTP ++APEV+ Y+ +A Sbjct: 150 DIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 206 Query: 200 DVWSCGVTLYVMLVGAYPFED 220 D+WS G+T M G P+ D Sbjct: 207 DIWSLGITAIEMAEGKPPYAD 227 >6GU6-A nrPDB Length = 302 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 136/290 (46%), Gaps = 39/290 (13%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRHPN 77 Y ++ IG G +GV R K T ++VA+K I R + +E V REI + LRHPN Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 67 Query: 78 IVRFKEVILTPTHLAIIMEYASGG-ELYERICNAGRFSEDE-ARFFFQQLLSGVSYCHSM 135 IV ++V++ + L +I E+ S + Y G++ + + + Q+L G+ +CHS Sbjct: 68 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 127 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLRQEY 194 ++ HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 128 RVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 195 DGKIADVWSCGVTLYVMLVGAYP-------------------------FEDPEEPRDYRK 229 D+WS G T++ L P + + E +DY+ Sbjct: 186 YSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 244 Query: 230 TIQRILSVKYSIPDDIR-ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 T + S+ ++ + L+S++ + DPA RIS H +F Sbjct: 245 TFPKWKPG--SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >3DTC-A nrPDB Length = 271 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 105/206 (50%), Gaps = 21/206 (10%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYI-----ERGDKIDENVQREIINHRSLRHPNIVRFK 82 IG G FG ++ R + VAVK E + ENV++E L+HPNI+ + Sbjct: 15 IGIGGFG--KVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS---MQICH 139 V L +L ++ME+A GG L R+ + R D + Q+ G++Y H + I H Sbjct: 73 GVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIH 131 Query: 140 RDLKLENTLL-----DGSPAPR-LKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQ 192 RDLK N L+ +G + + LKI DFG ++ H K S G A++APEV +R Sbjct: 132 RDLKSSNILILQKVENGDLSNKILKITDFGLARE--WHRTTKMSAAGAYAWMAPEV-IRA 188 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPF 218 K +DVWS GV L+ +L G PF Sbjct: 189 SMFSKGSDVWSYGVLLWELLTGEVPF 214 >5UUU-A nrPDB Length = 547 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 129/297 (43%), Gaps = 38/297 (12%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH-------PNIVR 80 IG G FG R T ++ A+K +++ + + +N R + P IV Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + H+ + +R Sbjct: 266 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 325 Query: 141 DLKLENTLLDGSPAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 DLK N LLD R+ CDF K P ++VGT Y+APEVL + Sbjct: 326 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 378 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 AD +S G L+ +L G PF + +D + + L++ +PD SPE L+ Sbjct: 379 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLE 435 Query: 257 RIFVADPATRISI-----------PEIKTHSW---FLKNLPADLM---NESNTGSQF 296 + D R+ P ++ W FL+ P L+ E N F Sbjct: 436 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 492 >4AU8-A nrPDB Length = 296 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/225 (30%), Positives = 110/225 (48%), Gaps = 10/225 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLR 74 S +Y+ ++ IG G +G +++ T E+VA+K + R D DE V REI + L+ Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-RLDDDDEGVPSSALREICLLKELK 63 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 H NIVR +V+ + L ++ E+ + Y CN G + + F QLL G+ +CH Sbjct: 64 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFLFQLLKGLGFCH 122 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQ 192 S + HRDLK +N L++ + LK+ DFG +++ + + S V T Y P+VL Sbjct: 123 SRNVLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + D+WS G + P + D K I R+L Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 225 >3PVW-A nrPDB Length = 695 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 129/297 (43%), Gaps = 38/297 (12%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH-------PNIVR 80 IG G FG R T ++ A+K +++ + + +N R + P IV Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + H+ + +R Sbjct: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Query: 141 DLKLENTLLDGSPAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 DLK N LLD R+ CDF K P ++VGT Y+APEVL + Sbjct: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 369 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 AD +S G L+ +L G PF + +D + + L++ +PD SPE L+ Sbjct: 370 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLE 426 Query: 257 RIFVADPATRISI-----------PEIKTHSW---FLKNLPADLM---NESNTGSQF 296 + D R+ P ++ W FL+ P L+ E N F Sbjct: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 >4G3E-A nrPDB Length = 352 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 12/197 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G+FG M+DK T AVK + +++ E++ L P IV + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKV----RLEVFRVEELVACAGLSSPRIVPLYGAVRE 137 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 + I ME GG L + I G ED A ++ Q L G+ Y H+ +I H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNV 197 Query: 148 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLRQEYDGKIADV 201 LL S R +CDFG++ KS + GT ++APEV++ + D K+ D+ Sbjct: 198 LLS-SDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV-DI 255 Query: 202 WSCGVTLYVMLVGAYPF 218 WS + ML G +P+ Sbjct: 256 WSSCCMMLHMLNGCHPW 272 >4GS6-A nrPDB Length = 315 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 129/269 (47%), Gaps = 30/269 (11%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-- 73 M D + + +G G FGV + + K + VA+K IE + + I+ R L Sbjct: 5 MIDYKEIEVEEVVGRGAFGV--VCKAKWRAKDVAIKQIES----ESERKAFIVELRQLSR 58 Query: 74 -RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA---GRFSEDEARFFFQQLLSGV 129 HPNIV+ L P + ++MEYA GG LY + A ++ A + Q GV Sbjct: 59 VNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 130 SYCHSMQ---ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 +Y HSMQ + HRDLK N LL LKICDFG + + + + G+ A++AP Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAG-GTVLKICDFG--TACDIQTHMTNNKGSAAWMAP 173 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--SIPDD 244 EV Y K DV+S G+ L+ ++ PF++ P RI+ + + P Sbjct: 174 EVFEGSNYSEK-CDVFSWGIILWEVITRRKPFDEIGGPAF------RIMWAVHNGTRPPL 226 Query: 245 IRISPECCH-LISRIFVADPATRISIPEI 272 I+ P+ L++R + DP+ R S+ EI Sbjct: 227 IKNLPKPIESLMTRCWSKDPSQRPSMEEI 255 >4NST-A nrPDB Length = 351 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 68/205 (33%), Positives = 98/205 (47%), Gaps = 19/205 (9%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRH 75 D++D + IG G +G +DK T ELVA+K + R D E REI R L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKV-RLDNEKEGFPITAIREIKILRQLIH 71 Query: 76 PNIVRFKEVILTPT----------HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 ++V KE++ ++ EY + FSED + F +QL Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKST-VGTPAY 183 + G+ YCH HRD+K N LL+ S ++K+ DFG ++ + S+P + V T Y Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNS--GQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTL 208 PE+LL +E DVWSCG L Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCIL 214 >1V0B-A nrPDB Length = 288 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 86/294 (29%), Positives = 134/294 (45%), Gaps = 40/294 (13%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRH 75 ++Y ++ IG G +GV ++ E A+K I R +K DE + REI + L+H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNYG-ETFALKKI-RLEKEDEGIPSTTIREISILKELKH 59 Query: 76 PNIVRFKEVILTPTHLAIIMEYASG--GELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 NIV+ +VI T L ++ E+ +L + +C G A+ F QLL+G++YCH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLD-VCEGG-LESVTAKSFLLQLLNGIAYCH 117 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLRQ 192 ++ HRDLK +N L++ LKI DFG +++ + + V T Y AP+VL+ Sbjct: 118 DRRVLHRDLKPQNLLINRE--GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV-------------KY 239 + D+WS G M+ GA F E D I RIL KY Sbjct: 176 KKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEA-DQLMRIFRILGTPNSKNWPNVTELPKY 234 Query: 240 SIPDDIRISP------------ECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 P+ P L+S++ DP RI+ + H++F +N Sbjct: 235 D-PNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4IDT-A nrPDB Length = 356 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 27/257 (10%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G+FG M DK T AVK + +++ E++ L P IV + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKV----RLEVFRAEELMACAGLTSPRIVPLYGAVRE 137 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 + I ME GG L + + G ED A ++ Q L G+ Y HS +I H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNV 197 Query: 148 LL--DGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLRQEYDGKIA 199 LL DGS A +CDFG++ K + GT ++APEV+L + D K+ Sbjct: 198 LLSSDGSHA---ALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKV- 253 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI- 258 DVWS + ML G +P+ + +R + L + P I P C L ++ Sbjct: 254 DVWSSCCMMLHMLNGCHPWT-----QFFRGPL--CLKIASEPPPVREIPPSCAPLTAQAI 306 Query: 259 ---FVADPATRISIPEI 272 +P R+S E+ Sbjct: 307 QEGLRKEPIHRVSAAEL 323 >6CKI-A nrPDB Length = 316 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 87/298 (29%), Positives = 127/298 (42%), Gaps = 31/298 (10%) Query: 20 DRYDFVKDI-GSGNFGVARLMRDKLTKELVAVKYIERG-DKIDENVQREI-INHRSLRHP 76 D Y +D+ G G + + +T + AVK IE+ I V RE+ + ++ H Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHR 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N++ E ++ E GG + I F+E EA Q + S + + H+ Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 137 ICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHS--QPKST------VGTPAYIAPE 187 I HRDLK EN L + + +KICDFG L+ P ST G+ Y+APE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 188 VL--LRQE---YDGKIADVWSCGVTLYVMLVGAYPF-----------EDPEEPRDYRKTI 231 V+ +E YD K D+WS GV LY++L G PF P Sbjct: 192 VVEAFSEEASIYD-KRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 232 QRILSVKYSIPDD--IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLM 287 + I KY PD IS LIS++ V D R+S ++ H W P + + Sbjct: 251 ESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL 308 >4AGU-A nrPDB Length = 311 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 132/291 (45%), Gaps = 37/291 (12%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGDK--IDENVQREIINHRSLRHP 76 ++Y+ + IG G++GV R++ T ++VA+K ++E D I + REI + L+HP Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N+V EV L ++ EY L+E E + Q L V++CH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHN 122 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK----STVGTPAYIAPEVLLRQ 192 HRD+K EN L+ +K+CDFG+++ L + P V T Y +PE+L+ Sbjct: 123 CIHRDVKPENILITKHSV--IKLCDFGFAR---LLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 193 EYDGKIADVWSCGVTLYVMLVGA--YPFE-DPEEPRDYRKTI-------QRILS------ 236 G DVW+ G +L G +P + D ++ RKT+ Q++ S Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 237 -VKYSIPDDIR--------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 VK P+D+ IS L+ DP R++ ++ H +F Sbjct: 238 GVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >4FR4-A nrPDB Length = 384 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 8/205 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRH 75 D ++ ++ IG G+FG +++ TK++ A+KY+ + ++ N R + + L H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V + ++++ GG+L + F E+ + F +L+ + Y + Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 134 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 +I HRD+K +N LLD + I DF + +Q + GT Y+APE+ ++ Sbjct: 135 RIIHRDMKPDNILLDEH--GHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGA 192 Query: 196 GK--IADVWSCGVTLYVMLVGAYPF 218 G D WS GVT Y +L G P+ Sbjct: 193 GYSFAVDWWSLGVTAYELLRGRRPY 217 >4FZF-B nrPDB Length = 283 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 78/264 (29%), Positives = 122/264 (46%), Gaps = 26/264 (9%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+FG D T+++VA+K I+ + E++Q+EI + ++ Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 75 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L + L IIMEY GG + + AG F E + +++L G+ Y HS + HRD+K Sbjct: 76 LKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAA 134 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLLRQEYDGKIADVWS 203 N LL S +K+ FG + + +Q K + VGTP ++APEV+ + YD K AD+WS Sbjct: 135 NVLL--SEQGDVKLAAFGVA-GQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK-ADIWS 190 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD------IRISPECCHLISR 257 G+T + G P D R V + IP + + I Sbjct: 191 LGITAIELAKGEPPNSDMHPMR-----------VLFLIPKNNPPTLVGDFTKSFKEFIDA 239 Query: 258 IFVADPATRISIPEIKTHSWFLKN 281 DP+ R + E+ H + +KN Sbjct: 240 CLNKDPSFRPTAKELLKHKFIVKN 263 >3NIZ-A nrPDB Length = 311 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 130/289 (44%), Gaps = 35/289 (12%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRH 75 ++Y ++ +G G +GV +D + +VA+K I R D DE + REI + L H Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKDSQGR-IVALKRI-RLDAEDEGIPSTAIREISLLKELHH 78 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIV +VI + L ++ E+ N + + + + QLL GV++CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQH 138 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLRQEY 194 +I HRDLK +N L++ A LK+ DFG +++ + + + V T Y AP+VL+ + Sbjct: 139 RILHRDLKPQNLLINSDGA--LKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 195 DGKIADVWSCGVTLYVMLVGAYPF-------EDPE--------EPRDYRKT------IQR 233 D+WS G M+ G F + P+ PR++ + QR Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 234 ILSVKYSIPDDIRISPECCH----LISRIFVADPATRISIPEIKTHSWF 278 V P I P C L+S + DP RIS + H +F Sbjct: 257 TFQVFEKKPWS-SIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >4KIK-B nrPDB Length = 677 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 73/240 (30%), Positives = 111/240 (46%), Gaps = 21/240 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLRHPNI 78 ++ + +G+G FG ++ T E +A+K R + N +R EI R L HPN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHPNV 79 Query: 79 VRFKEV-----ILTPTHLAII-MEYASGGEL------YERICNAGRFSEDEARFFFQQLL 126 V ++V L P L ++ MEY GG+L +E C E + Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCG---LREGAILTLLSDIA 136 Query: 127 SGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 S + Y H +I HRDLK EN +L G KI D GY+K S S VGT Y+A Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE+L +Q+Y + D WS G + + G PF +P + +++ V + +D+ Sbjct: 197 PELLEQQKYTVTV-DYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDL 255 >5KKR-C nrPDB Length = 395 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 106/208 (50%), Gaps = 11/208 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH---- 75 D ++ + ++G+GN GV + K + ++A K I +I ++ +II + H Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 125 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HS 134 P IV F + ++I ME+ GG L + + AGR E ++ G++Y Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 185 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 +I HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 186 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 242 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPE 222 + +D+WS G++L M VG YP P+ Sbjct: 243 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 269 >1S9I-A nrPDB Length = 354 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 107/208 (51%), Gaps = 11/208 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH---- 75 D ++ + ++G+GN GV ++ + + ++A K I +I ++ +II + H Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL--EIKPAIRNQIIRELQVLHECNS 73 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HS 134 P IV F + ++I ME+ GG L + + A R E+ +L G++Y Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 QI HRD+K N L++ +K+CDFG S ++ S S VGT +Y+APE L Y Sbjct: 134 HQIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMAPERLQGTHY 190 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPE 222 + +D+WS G++L + VG YP P+ Sbjct: 191 SVQ-SDIWSMGLSLVELAVGRYPIPPPD 217 >3TKU-A nrPDB Length = 433 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 77/284 (27%), Positives = 128/284 (45%), Gaps = 33/284 (11%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE------NVQREIIN 69 +H D ++ +K IG G FG +++ K T+ + A+K + + + + +R+++ Sbjct: 87 LHRED-FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV 145 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSG 128 + + I HL ++M+Y GG+L + + ED ARF+ +++ Sbjct: 146 NGDCQW--ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLA 203 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPR-------LKICDFGYSKSSVLHSQPKSTVGTP 181 + H + HRD+K +N LLD + R LK+ D G +SSV VGTP Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSV-------AVGTP 256 Query: 182 AYIAPEVLLRQEYD----GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 YI+PE+L E G D WS GV +Y ML G PF Y K + Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--EE 314 Query: 238 KYSIPDDIR-ISPECCHLISRIFVADP--ATRISIPEIKTHSWF 278 ++ P + +S E LI R+ + + I + K H++F Sbjct: 315 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF 358 >4BBM-A nrPDB Length = 331 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 102/201 (50%), Gaps = 10/201 (4%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGD--KIDENVQREIINHRSLRHP 76 ++Y+ + +G G++G+ R+K T +VA+K ++E D + + REI + LRH Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 N+V EV ++ E+ L E N + + F Q+++G+ +CHS Sbjct: 85 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLF--QIINGIGFCHS 142 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQE 193 I HRD+K EN L+ S +K+CDFG++++ + V T Y APE+L+ Sbjct: 143 HNIIHRDIKPENILVSQSGV--VKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDV 200 Query: 194 YDGKIADVWSCGVTLYVMLVG 214 GK DVW+ G + M +G Sbjct: 201 KYGKAVDVWAIGCLVTEMFMG 221 >5AIR-A nrPDB Length = 430 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 101/347 (29%), Positives = 153/347 (44%), Gaps = 58/347 (16%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 Y K IG+G+FGV + + ELVA+K + + DK +N RE+ R L H NIVR Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-DKRFKN--RELQIMRKLDHCNIVRL 122 Query: 82 KEVILTP------THLAIIMEYASGGELYERICNAGRFSEDE-------ARFFFQQLLSG 128 + + +L ++++Y E R+ A +S + + + QL Sbjct: 123 RYFFYSSGEKKDEVYLNLVLDYVP--ETVYRV--ARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 ++Y HS ICHRD+K +N LLD A LK+CDFG +K V S + + Y APE+ Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTA-VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 237 Query: 189 LL-RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS----------- 236 + +Y I DVWS G L +L+G P + D I ++L Sbjct: 238 IFGATDYTSSI-DVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 237 ---VKYSIPD----------DIRISPECCHLISRIFVADPATRISIPEIKTHSWF--LKN 281 ++ P R PE L SR+ P R++ E HS+F L++ Sbjct: 296 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 Query: 282 LPADLMNESNTGSQFQEPEQPMQS---LDTIM-----QIISEATIPA 320 L N +T + F Q + S L TI+ +I + A+ PA Sbjct: 356 PNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPA 402 >5EFQ-A nrPDB Length = 347 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 19/220 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRH 75 D++D + IG G +G RDK T E+VA+K + R D E REI R L H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKV-RLDNEKEGFPITAIREIKILRQLTH 69 Query: 76 PNIVRFKEVILTPT----------HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 +I+ KE++ ++ EY + F+E+ + F +QL Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 129 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKST-VGTPAY 183 + G+ YCH HRD+K N LL+ ++K+ DFG ++ S S+P + V T Y Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNR--GQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 PE+LL +E DVWSCG L + F+ +E Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE 227 >3EQC-A nrPDB Length = 360 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 106/208 (50%), Gaps = 11/208 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH---- 75 D ++ + ++G+GN GV + K + ++A K I +I ++ +II + H Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 90 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HS 134 P IV F + ++I ME+ GG L + + AGR E ++ G++Y Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 +I HRD+K N L++ +K+CDFG S ++ S S VGT +Y++PE L Y Sbjct: 151 HKIMHRDVKPSNILVNSRG--EIKLCDFGVS-GQLIDSMANSFVGTRSYMSPERLQGTHY 207 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPE 222 + +D+WS G++L M VG YP P+ Sbjct: 208 SVQ-SDIWSMGLSLVEMAVGRYPIPPPD 234 >4IC8-A nrPDB Length = 442 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 33/239 (13%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR-----EIINHRSL 73 D Y+ ++ IG+G +GV R +LT + VA+K I + N +R +I+ H Sbjct: 54 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--F 111 Query: 74 RHPNIVRFKEVILTPT-------HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLL 126 +H NI+ K+ IL PT + ++++ +L++ I ++ + + R+F QLL Sbjct: 112 KHDNIIAIKD-ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-------STVG 179 G+ Y HS Q+ HRDLK N L++ + LKI DFG ++ L + P V Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARG--LCTSPAEHQYFMTEYVA 225 Query: 180 TPAYIAPEVLLR-QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 T Y APE++L EY I D+WS G ML F ++Y +Q I+ V Sbjct: 226 TRWYRAPELMLSLHEYTQAI-DLWSVGCIFGEMLARRQLFPG----KNYVHQLQLIMMV 279 >3DAK-A nrPDB Length = 290 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/291 (28%), Positives = 132/291 (45%), Gaps = 28/291 (9%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINH 70 +P + D Y+ + IGSG V + KE VA+K I E+ + + +EI Sbjct: 3 LPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAM 62 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN--------AGRFSEDEARFFF 122 HPNIV + + L ++M+ SGG + + I + +G E Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSK-----SSVLHSQPK 175 +++L G+ Y H HRD+K N LL DGS ++I DFG S + ++ + Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGS----VQIADFGVSAFLATGGDITRNKVR 178 Query: 176 ST-VGTPAYIAPEVLLR-QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 T VGTP ++APEV+ + + YD K AD+WS G+T + GA P+ + T+Q Sbjct: 179 KTFVGTPCWMAPEVMEQVRGYDFK-ADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN 237 Query: 234 -ILSVKYSIPDD---IRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 S++ + D + +IS DP R + E+ H +F K Sbjct: 238 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >3QA8-A nrPDB Length = 676 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 91/334 (27%), Positives = 143/334 (42%), Gaps = 30/334 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPNIV 79 ++ + +G+G FG + T E VA+K E K E EI + L HPN+V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 80 RFKEV-----ILTPTHLAII-MEYASGGEL------YERICNAGRFSEDEARFFFQQLLS 127 +EV L P L ++ MEY GG+L +E C E R + S Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCG---LKEGPIRTLLSDISS 132 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRL--KICDFGYSKSSVLHSQPKSTVGTPAYIA 185 + Y H +I HRDLK EN +L P RL KI D GY+K VGT Y+A Sbjct: 133 ALRYLHENRIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGELCTEFVGTLQYLA 191 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE+L +++Y + D WS G + + G PF +P + ++ + + DD+ Sbjct: 192 PELLEQKKYTVTV-DYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDL 250 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP-MQ 304 + + ++ P I K W L + ++ G+ Q P Q Sbjct: 251 TGAVKFSSVL-----PTPNHLSGILAGKLERWLQCML---MWHQRQRGTDPQNPNVGCFQ 302 Query: 305 SLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDD 338 +LD+I+ + + + V R +T+N +L + Sbjct: 303 ALDSILSLKLLSVMNMVSGRVHTYPVTENENLQN 336 >4ZSG-A nrPDB Length = 347 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/236 (30%), Positives = 116/236 (49%), Gaps = 27/236 (11%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR-----EIINHRSL 73 D Y+ ++ IG+G +GV R +LT + VA+K I + N +R +I+ H Sbjct: 6 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH--F 63 Query: 74 RHPNIVRFKEVILTPT-------HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLL 126 +H NI+ K+ IL PT + ++++ +L++ I ++ + + R+F QLL Sbjct: 64 KHDNIIAIKD-ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKST--VGTP 181 G+ Y HS Q+ HRDLK N L++ + LKI DFG ++ +S Q T V T Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATR 179 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 Y APE++L + D+WS G ML F ++Y +Q I+ V Sbjct: 180 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPG----KNYVHQLQLIMMV 231 >4KRC-A nrPDB Length = 317 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 12/218 (5%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSL 73 M S ++ ++ +G+G + +K T VA+K ++ + REI + L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGG-ELY---ERICNAGRFSE-DEARFFFQQLLSG 128 +H NIVR +VI T L ++ E+ + Y + N R E + ++F QLL G Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE 187 +++CH +I HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP+ Sbjct: 121 LAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGA--YPFEDPEE 223 VL+ D+WSCG L M+ G +P + EE Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 >2F9G-A nrPDB Length = 353 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 83/298 (27%), Positives = 120/298 (40%), Gaps = 54/298 (18%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDK--IDENVQREIINHRSLRHPNIVRFKEVI 85 +G G +GV K T E+VA+K IE DK REI + +H NI+ I Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN-I 77 Query: 86 LTPTHLAIIMEYASGGELYE----RICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 P E EL + R+ + S+D ++F Q L V H + HRD Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 Query: 142 LKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKST-------VGTPAYIAPEVLL 190 LK N L++ + LK+CDFG ++ S+ +S+P V T Y APEV+L Sbjct: 138 LKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD------ 244 + DVWSCG L + + F RDYR + I + + D Sbjct: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFPG----RDYRHQLLLIFGIIGTPHSDNDLRCI 251 Query: 245 ------------------------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 R++P+ L+ R+ V DPA RI+ E H + Sbjct: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 >6DTL-A nrPDB Length = 364 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/185 (34%), Positives = 91/185 (49%), Gaps = 9/185 (4%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERG--DKID-ENVQREIINHRSLRHPNIVRFKEV 84 IG G +G+ + T E VA+K I +KID + REI R + H NIV +++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 85 ILTPTHLAIIMEYAS----GGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 I P A Y + +L++ I + SE+ ++F Q+L G+ Y HS + HR Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 157 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 DLK N LL+ + LKICDFG ++ + V T Y APE+LL D Sbjct: 158 DLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 215 Query: 201 VWSCG 205 VWS G Sbjct: 216 VWSVG 220 >6HXF-B nrPDB Length = 302 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 65/202 (32%), Positives = 105/202 (51%), Gaps = 19/202 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR---HPNI 78 ++ V ++G G FG ++K T L A K IE K +E ++ I+ L HP I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIE--TKSEEELEDYIVEIEILATCDHPYI 78 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQI 137 V+ L I++E+ GG + + R +E + + +Q+L +++ HS +I Sbjct: 79 VKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRI 138 Query: 138 CHRDLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE- 193 HRDLK N L L+G +++ DFG S ++ Q + S +GTP ++APEV++ + Sbjct: 139 IHRDLKAGNVLMTLEGD----IRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 194 Query: 194 ----YDGKIADVWSCGVTLYVM 211 YD K AD+WS G+TL M Sbjct: 195 KDTPYDYK-ADIWSLGITLIEM 215 >5X5O-A nrPDB Length = 310 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 71/209 (33%), Positives = 105/209 (50%), Gaps = 18/209 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 D F ++ G G+FG + + VAVK + + +K + EI++ L H NI+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK-----EAEILS--VLSHRNII 67 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVSYCHS-- 134 +F VIL P + I+ EYAS G LY+ I N+ R E D + + G+ Y H Sbjct: 68 QFYGVILEPPNYGIVTEYASLGSLYDYI-NSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 135 -MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 +++ HRDLK N ++ LKICDFG S+ H+ S VGT ++APEV+ Sbjct: 127 PVKVIHRDLKSRNVVIAADGV--LKICDFGASRFHN-HTTHMSLVGTFPWMAPEVIQSLP 183 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPE 222 + D +S GV L+ ML PF+ E Sbjct: 184 VS-ETCDTYSYGVVLWEMLTREVPFKGLE 211 >2HW6-A nrPDB Length = 307 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 123/294 (41%), Gaps = 31/294 (10%) Query: 20 DRYDFVKDI-GSGNFGVARLMRDKLTKELVAVKYIER-GDKIDENVQREIIN-HRSLRHP 76 D Y ++ G G + + + AVK IE+ V RE+ ++ + Sbjct: 12 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 NI+ E T ++ E GG + I F+E EA + + + + + H+ Sbjct: 72 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 137 ICHRDLKLENTLLDGSP--APRLKICDFGYSKSSVLH------SQPKSTV--GTPAYIAP 186 I HRDLK EN L + SP +KICDF L+ + P+ T G+ Y+AP Sbjct: 132 IAHRDLKPENILCE-SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAP 190 Query: 187 EVLL----RQEYDGKIADVWSCGVTLYVMLVGAYPF-----EDPEEPRD------YRKTI 231 EV+ + + K D+WS GV LY+ML G PF D R K Sbjct: 191 EVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLF 250 Query: 232 QRILSVKYSIPDD--IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLP 283 + I KY PD IS E LIS++ V D R+S ++ H W P Sbjct: 251 ESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 304 >6AO5-A nrPDB Length = 362 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 71/266 (26%), Positives = 120/266 (45%), Gaps = 18/266 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 +D ++ +G G++G K + ++VA+K + + E + +EI + P +V++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEII-KEISIMQQCDSPYVVKY 70 Query: 82 KEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T L I+MEY G + + I EDE + L G+ Y H M+ HR Sbjct: 71 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 130 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIA 199 ++K N LL+ K+ DFG + ++TV GTP ++APEV+ Y+ +A Sbjct: 131 NIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 187 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR----ISPECCHLI 255 D+WS G+T M G P+ D R I + + P R S + + Sbjct: 188 DIWSLGITSIEMAEGKPPYADIHPMR-------AIFMIPTNPPPTFRKPELWSDDFTDFV 240 Query: 256 SRIFVADPATRISIPEIKTHSWFLKN 281 + V +P R + ++ H F+KN Sbjct: 241 KKCLVKNPEQRATATQLLQHP-FIKN 265 >4LG4-A nrPDB Length = 299 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/267 (26%), Positives = 120/267 (44%), Gaps = 20/267 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 +D ++ +G G++G K + ++VA+K + + E + +EI + P +V++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-IIKEISIMQQCDSPYVVKY 71 Query: 82 KEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T L I+MEY G + + I EDE + L G+ Y H M+ HR Sbjct: 72 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 131 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-GTPAYIAPEVLLRQEYDGKIA 199 ++K N LL+ K+ DFG + ++TV GTP ++APEV+ Y+ +A Sbjct: 132 NIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC-VA 188 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH-----L 254 D+WS G+T M G P+ D R I + + P R PE Sbjct: 189 DIWSLGITSIEMAEGKPPYADIHPMR-------AIFMIPTNPPPTFR-KPELWSDDFTDF 240 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKN 281 + + V +P R + ++ H F+KN Sbjct: 241 VKKCLVKNPEQRATATQLLQHP-FIKN 266 >2BUJ-A nrPDB Length = 317 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/275 (28%), Positives = 117/275 (42%), Gaps = 28/275 (10%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHP 76 D+ Y F++ +G G F L+ A+K I ++ D E QRE HR HP Sbjct: 27 DNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHP 86 Query: 77 NIVRFKEVIL---TPTHLA-IIMEYASGGELY---ERICNAGRF-SEDEARFFFQQLLSG 128 NI+R L H A +++ + G L+ ER+ + G F +ED+ + + G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---------- 178 + H+ HRDLK N LL P L D G + +H + Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLM--DLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 179 GTPAYIAPEVLLRQEY---DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 T +Y APE+ Q + D + DVWS G LY M+ G P++ + D ++ + Sbjct: 205 CTISYRAPELFSVQSHCVIDER-TDVWSLGCVLYAMMFGEGPYDMVFQKGD---SVALAV 260 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 + SIP R S L++ + DP R IP Sbjct: 261 QNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIP 295 >4AN9-A nrPDB Length = 301 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/267 (25%), Positives = 126/267 (47%), Gaps = 15/267 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH---- 75 D ++ + ++G+GN GV + K + ++A K I +I ++ +II + H Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL--EIKPAIRNQIIRELQVLHECNS 66 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HS 134 P IV F + ++I ME+ GG L + + AGR E ++ G++Y Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 +I HRD+K N L++ +K+CDFG S ++ VGT +Y++PE L Y Sbjct: 127 HKIMHRDVKPSNILVNSR--GEIKLCDFGVS-GQLIDEMANEFVGTRSYMSPERLQGTHY 183 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 + +D+WS G++L M VG Y P P + + I++ S E Sbjct: 184 SVQ-SDIWSMGLSLVEMAVGRY----PRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDF 238 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKN 281 +++ + +PA R + ++ H++ ++ Sbjct: 239 VNKCLIKNPAERADLKQLMVHAFIKRS 265 >3NYO-A nrPDB Length = 576 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 138/312 (44%), Gaps = 37/312 (11%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 ++R PVT + + + +G G FG + + T ++ A K +E+ Sbjct: 176 LERQPVT-----------KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK 224 Query: 61 ENVQREIINHRSLRHPNIVRFKEVIL----TPTHLAIIMEYASGGELYERICNAGR--FS 114 + +N + + RF + T L +++ +GG+L I + G+ F Sbjct: 225 RKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP 284 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 E A F+ ++ G+ H +I +RDLK EN LLD ++I D G + Sbjct: 285 EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTI 342 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 K VGT Y+APEV+ + Y D W+ G LY M+ G PF+ + + R+ ++R+ Sbjct: 343 KGRVGTVGYMAPEVVKNERYTFS-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERL 400 Query: 235 LSVKYSIPDDI--RISPECCHLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLM 287 + +P++ R SP+ L S++ DPA R+ S E+K H F K + Sbjct: 401 VK---EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK------L 451 Query: 288 NESNTGSQFQEP 299 N G+ EP Sbjct: 452 NFKRLGAGMLEP 463 >4F0G-A nrPDB Length = 287 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/273 (28%), Positives = 129/273 (47%), Gaps = 30/273 (10%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGV---ARLMRDKLTKELVAVKYIERGDKIDEN------- 62 +P + D++ ++ K IG G FG+ RL++D K +VA+K + GD E Sbjct: 13 LPTLADNE-IEYEKQIGKGGFGLVHKGRLVKD---KSVVAIKSLILGDSEGETEMIEKFQ 68 Query: 63 -VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF- 120 QRE+ +L HPNIV+ ++ P + +ME+ G+LY R+ + + + Sbjct: 69 EFQREVFIMSNLNHPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKAHPIKWSVKLR 126 Query: 121 FFQQLLSGVSYCHSMQ--ICHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQPK 175 + G+ Y + I HRDL+ N LD + K+ DFG S+ SV HS Sbjct: 127 LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSV-HSV-S 184 Query: 176 STVGTPAYIAPEVLLRQE--YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 +G ++APE + +E Y K AD +S + LY +L G PF++ + + R Sbjct: 185 GLLGNFQWMAPETIGAEEESYTEK-ADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIR 243 Query: 234 ILSVKYSIPDDIRISPECCHLISRIFVADPATR 266 ++ +IP+D P ++I + DP R Sbjct: 244 EEGLRPTIPED--CPPRLRNVIELCWSGDPKKR 274 >3ZDU-A nrPDB Length = 325 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 83/322 (25%), Positives = 136/322 (42%), Gaps = 47/322 (14%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGDK-IDENVQREIINHRSLRHPN 77 + Y+ + +G G++G + K T ++VA+K + ER ++ +++ REI + H N Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 62 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V EV + ++ E+ L E R + Q+L + Y HS I Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST----VGTPAYIAPEVLLRQE 193 HRD+K EN L+ S +L CDFG++++ + P V T Y APE++L+ Sbjct: 123 IHRDIKPENILVSQSGITKL--CDFGFARTL---AAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI-----------QRILSV----- 237 GK D+W+ G + M G P+ D I Q I S Sbjct: 178 SYGKPVDIWALGCMIIEMATGN-PYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 238 -----KYSIPDDIRIS-PECCHLISRIFVA----DPATRISIPEIKTHSWFLKN------ 281 + P + R P+ L++ I A DPA RIS ++ H +F ++ Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKF 296 Query: 282 ---LPADLMNESNTGSQFQEPE 300 L A L+ E+ S + E Sbjct: 297 MPELKAKLLQEAKVNSLIKPKE 318 >5DBX-A nrPDB Length = 328 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 79/267 (29%), Positives = 119/267 (44%), Gaps = 50/267 (18%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHR 71 PI D+ Y+ + IGSG V + K +E VA+K I E+ + + +EI Sbjct: 7 PICRDA--YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMS 64 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELY---ERICNAGR-----FSEDEARFFFQ 123 HPN+V + + L ++M+ SGG + + I N G E + Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSK------SSVLHSQPK 175 ++L G+ Y H HRDLK N LL DGS ++I DFG S + K Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGS----VQIADFGVSAFLATGGDVTRNKVRK 180 Query: 176 STVGTPAYIAPEVLLR-QEYDGKIADVWSCGVTLYVMLVGAYPF---------------- 218 VGTP ++APEV+ + + YD K AD+WS G+T + GA P+ Sbjct: 181 DFVGTPCWMAPEVMEQVRGYDFK-ADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND 239 Query: 219 --------EDPEEPRDYRKTIQRILSV 237 ED E + Y K+ +++LS+ Sbjct: 240 PPTLETGVEDKEMMKKYGKSFRKLLSL 266 >1UA2-A nrPDB Length = 346 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/318 (25%), Positives = 130/318 (40%), Gaps = 39/318 (12%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG------DKIDENVQREIINHRS 72 + RY+ + +G G F RDK T ++VA+K I+ G D I+ REI + Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 L HPNI+ + ++++++ ++ N+ + + + L G+ Y Sbjct: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLR 191 H I HRDLK N LLD + LK+ DFG +KS ++ + V T Y APE+L Sbjct: 129 HQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--------SIPD 243 G D+W+ G L +L+ PF + D I L S+PD Sbjct: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Query: 244 DIRISP---------------ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 + + LI +F+ +P RI+ + +F N P Sbjct: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-SNRPG---- 300 Query: 289 ESNTGSQFQEPEQPMQSL 306 G Q P P+++L Sbjct: 301 -PTPGCQLPRPNCPVETL 317 >5G6V-A nrPDB Length = 324 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 106/217 (48%), Gaps = 14/217 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 +G G + + KLT LVA+K I E + RE+ + L+H NIV ++I Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDII 69 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRF-SEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 T L ++ EY +L + + + G + + F QLL G++YCH ++ HRDLK Sbjct: 70 HTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKP 128 Query: 145 ENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL-RQEYDGKIADVW 202 +N L++ LK+ DFG +++ + ++ + V T Y P++LL +Y +I D+W Sbjct: 129 QNLLIN--ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQI-DMW 185 Query: 203 SCGVTLYVMLVG--AYPFEDPEEPRDYRKTIQRILSV 237 G Y M G +P EE + I RIL Sbjct: 186 GVGCIFYEMATGRPLFPGSTVEEQLHF---IFRILGT 219 >5NGU-A nrPDB Length = 381 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/202 (32%), Positives = 93/202 (46%), Gaps = 13/202 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNI 78 RY + IG G +G+ D L K VA+K I + REI RH NI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 79 VRFKEVILTPTHLAI----IMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 + ++I PT + I++ +LY ++ S D +F Q+L G+ Y HS Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHS 161 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 190 + HRDLK N LL+ + LKICDFG ++ + H V T Y APE++L Sbjct: 162 ANVLHRDLKPSNLLLNTTCD--LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 191 RQEYDGKIADVWSCGVTLYVML 212 + K D+WS G L ML Sbjct: 220 NSKGYTKSIDIWSVGCILAEML 241 >5Z33-A nrPDB Length = 425 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 79/307 (25%), Positives = 129/307 (42%), Gaps = 61/307 (19%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----- 74 +RY K++G G +G+ + T E VA+K K+ ++I+ R+LR Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIK------KVTNVFSKKILAKRALREIKLL 84 Query: 75 -----HPNIVRFKEV-ILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLL 126 H NI ++ I P + + E +L I + ++ + F Q+L Sbjct: 85 QHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQIL 144 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-----VGTP 181 G+ Y HS + HRDLK N L++ LKICDFG ++ + + + V T Sbjct: 145 CGLKYIHSANVLHRDLKPGNLLVNAD--CELKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 Y APE++L + K DVWS G L L+G PF + RDY + +IL + Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCIL-AELLGGRPF---FKGRDYVDQLNQILHI-LGT 257 Query: 242 PDDIRIS------------------------------PECCHLISRIFVADPATRISIPE 271 P++ +S P+ L+ R+ DP++RIS+ + Sbjct: 258 PNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQ 317 Query: 272 IKTHSWF 278 H + Sbjct: 318 ALEHPYL 324 >4EWQ-A nrPDB Length = 383 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 130/304 (42%), Gaps = 44/304 (14%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQREI 67 L+ I +RY + +GSG +G D T VAVK + R + + RE+ Sbjct: 36 LNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYREL 95 Query: 68 INHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFSEDEARFFF 122 + ++H N++ +V L ++ + G +L I + ++D +F Sbjct: 96 RLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLI 154 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGT 180 Q+L G+ Y HS I HRDLK N L + LKI DFG ++ H+ + T V T Sbjct: 155 YQILRGLKYIHSADIIHRDLKPSN--LAVNEDCELKILDFGLAR----HTDDEMTGYVAT 208 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG--AYPFED------------------ 220 Y APE++L + + D+WS G + +L G +P D Sbjct: 209 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 268 Query: 221 ------PEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 E R+Y +++ ++ + ++ I +P L+ ++ V D RI+ + Sbjct: 269 LLKKISSESARNYIQSLTQMPKMNFA-NVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 327 Query: 275 HSWF 278 H++F Sbjct: 328 HAYF 331 >5D7A-A nrPDB Length = 308 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 114/238 (47%), Gaps = 22/238 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREI-INHRSLRHPNIVR 80 ++ V+ +G+G +G R T +L A+K ++ +E +++EI + + H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 81 FKEVILTPT------HLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYC 132 + + L ++ME+ G + + I N E+ + +++L G+S+ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLR 191 H ++ HRD+K +N LL + +K+ DFG S ++T +GTP ++APEV+ Sbjct: 139 HQHKVIHRDIKGQNVLL--TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 196 Query: 192 QE-----YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY----RKTIQRILSVKYS 240 E YD K +D+WS G+T M GA P D R R R+ S K+S Sbjct: 197 DENPDATYDFK-SDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWS 253 >4TNB-A nrPDB Length = 590 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 118/278 (42%), Gaps = 24/278 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRS-LRHPN---IVRFKE 83 +G G FG + + T ++ A K +E+ + +N + L N +V Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQICHRD 141 T L +++ +GG+L I N G F E+ A F+ ++L G+ H +RD Sbjct: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRD 311 Query: 142 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADV 201 LK EN LLD ++I D G + + VGT Y+APEVL Q Y G D Sbjct: 312 LKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDY 368 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK--YSIPDDIRISPECCHLISRIF 259 W G +Y M+ G PF +E + +R+L + YS + S E + + Sbjct: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS----HKFSEEAKSICKMLL 424 Query: 260 VADPATRISI-----PEIKTHSWF----LKNLPADLMN 288 D R+ E+K H +F K L A +++ Sbjct: 425 TKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLD 462 >4U41-A nrPDB Length = 332 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 18/214 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREI-INHRSLRHPNIVR 80 ++ V+ +G+G +G R T +L A+K ++ + +E ++ EI + + H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 81 FKEVILT---PTH---LAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYC 132 + + P H L ++ME+ G + + + N ED + +++L G+++ Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLR 191 H + HRD+K +N LL + +K+ DFG S ++T +GTP ++APEV+ Sbjct: 146 HIHHVIHRDIKGQNVLL--TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 203 Query: 192 QE-----YDGKIADVWSCGVTLYVMLVGAYPFED 220 E YD + +D+WSCG+T M GA P D Sbjct: 204 DENPDATYDYR-SDLWSCGITAIEMAEGAPPLCD 236 >4PWN-A nrPDB Length = 274 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 75/276 (27%), Positives = 128/276 (46%), Gaps = 22/276 (7%) Query: 16 MHDSDRY-DFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH---- 70 M + R+ F +IG G+F D T+ V V + E D+ +R+ Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLD--TETTVEVAWCELQDRKLTKSERQRFKEEAEM 62 Query: 71 -RSLRHPNIVRF----KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 + L+HPNIVRF + + + ++ E + G L + R + +Q+ Sbjct: 63 LKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQI 122 Query: 126 LSGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 L G+ + H+ I HRDLK +N + G P +KI D G + S KS +GTP + Sbjct: 123 LKGLQFLHTRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLATLEKRASFAKSVIGTPEF 181 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS-VKYSIP 242 +APE + ++YD + DV++ G+ + M YP+ E ++ + +R+ S VK + Sbjct: 182 MAPE-MYEEKYDESV-DVYAFGMCMLEMATSEYPY---SECQNAAQIYRRVTSGVKPASF 236 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 D + I PE +I + R SI ++ H++F Sbjct: 237 DKVAI-PEVKEIIEGCIRQNKDERYSIKDLLNHAFF 271 >3SXS-A nrPDB Length = 268 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/201 (31%), Positives = 101/201 (50%), Gaps = 10/201 (4%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 +K++GSG FGV +L + K + VAVK I+ G ++ +E L HP +V+F Sbjct: 12 LLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 70 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF-FFQQLLSGVSYCHSMQICHRDL 142 V + I+ EY S G L + + G+ E + G+++ S Q HRDL Sbjct: 71 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 130 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIA 199 N L+D +K+ DFG ++ VL Q S+VGT + APEV +Y K + Sbjct: 131 AARNCLVDRDLC--VKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSK-S 186 Query: 200 DVWSCGVTLY-VMLVGAYPFE 219 DVW+ G+ ++ V +G P++ Sbjct: 187 DVWAFGILMWEVFSLGKMPYD 207 >4QTB-A nrPDB Length = 380 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 97/202 (48%), Gaps = 13/202 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNI 78 RY ++ IG G +G+ D + K VA+K I + REI RH N+ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 79 VRFKEVILTPTHLAI----IMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 + ++++ T A+ I++ +LY ++ + + S D +F Q+L G+ Y HS Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS 160 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 190 + HRDLK N L++ + LKICDFG ++ + H V T Y APE++L Sbjct: 161 ANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 191 RQEYDGKIADVWSCGVTLYVML 212 + K D+WS G L ML Sbjct: 219 NSKGYTKSIDIWSVGCILAEML 240 >2WQN-A nrPDB Length = 310 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 16/204 (7%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVRF 81 K IG G F L VA+K ++ D +D + + I + L HPN++++ Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGR----FSEDEARFFFQQLLSGVSYCHSMQI 137 + L I++E A G+L I + + E +F QL S + + HS ++ Sbjct: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157 Query: 138 CHRDLKLENTLLDGSPAPR---LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 HRD+K N + + + L + F SK++ H S VGTP Y++PE + Y Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAH----SLVGTPYYMSPERIHENGY 213 Query: 195 DGKIADVWSCGVTLYVMLVGAYPF 218 + K +D+WS G LY M PF Sbjct: 214 NFK-SDIWSLGCLLYEMAALQSPF 236 >3QGY-A nrPDB Length = 286 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 104/220 (47%), Gaps = 12/220 (5%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR 65 V G L M I D FV++IGSG FG+ L L K+ VA+K I+ G +++ Sbjct: 15 VPRGSLHMVI--DPSELTFVQEIGSGQFGLVHLGY-WLNKDKVAIKTIKEGSMSEDDFIE 71 Query: 66 EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQ 124 E L HP +V+ V L + ++ E+ G L + + G F+ + Sbjct: 72 EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLD 131 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 181 + G++Y + HRDL N L+ + +K+ DFG ++ VL Q S+ GT Sbjct: 132 VCEGMAYLEEACVIHRDLAARNCLVGENQV--IKVSDFGMTR-FVLDDQYTSSTGTKFPV 188 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 + +PEV Y K +DVWS GV ++ V G P+E+ Sbjct: 189 KWASPEVFSFSRYSSK-SDVWSFGVLMWEVFSEGKIPYEN 227 >5O2C-A nrPDB Length = 380 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 68/264 (25%), Positives = 121/264 (45%), Gaps = 22/264 (8%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-----RSLRHPNIVRF 81 ++G G F D T+ V V + E D+ +++ + L+HPNIVRF Sbjct: 32 ELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRF 89 Query: 82 ----KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ- 136 + ++ + ++ E + G L + R + +Q+L G+ + H+ Sbjct: 90 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + + YD Sbjct: 150 PIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE-MYEEHYD 206 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRD-YRKTIQRILSVKYSIPDDIRISPECCHL 254 + DV++ G+ + M YP+ + + YRK I ++ D PE + Sbjct: 207 ESV-DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTD----PEVKEI 261 Query: 255 ISRIFVADPATRISIPEIKTHSWF 278 I + + R+SI ++ H++F Sbjct: 262 IEGCIRQNKSERLSIRDLLNHAFF 285 >5HVK-A nrPDB Length = 315 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 83/297 (27%), Positives = 134/297 (45%), Gaps = 44/297 (14%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVRFKE 83 +G G FG A + + T E++ +K + R DE QR + R L HPN+++F Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 84 VILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 V+ L I EY GG L I + ++ + F + + SG++Y HSM I HR+L Sbjct: 79 VLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRNL 138 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPK--------------STVGTPAYIAPE 187 N L+ + + + DFG ++ V +QP+ + VG P ++APE Sbjct: 139 NSHNCLVREN--KNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPR--DYRKTIQRILSVKYSIPD-- 243 ++ + YD K+ DV+S G+ L ++G + PR D+ ++ L +Y P+ Sbjct: 197 MINGRSYDEKV-DVFSFGIVL-CEIIGRVNADPDYLPRTMDFGLNVRGFLD-RYCPPNCP 253 Query: 244 --DIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 I+ CC L DP R S +K W L+ L L G Q ++ Sbjct: 254 PSFFPITVRCCDL-------DPEKRPSF--VKLEHW-LETLRMHLAGHLPLGPQLEQ 300 >5O2B-A nrPDB Length = 285 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 68/264 (25%), Positives = 121/264 (45%), Gaps = 22/264 (8%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-----RSLRHPNIVRF 81 ++G G F D T+ V V + E D+ +++ + L+HPNIVRF Sbjct: 23 ELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRF 80 Query: 82 ----KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ- 136 + ++ + ++ E + G L + R + +Q+L G+ + H+ Sbjct: 81 YDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + + YD Sbjct: 141 PIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE-MYEEHYD 197 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRD-YRKTIQRILSVKYSIPDDIRISPECCHL 254 + DV++ G+ + M YP+ + + YRK I ++ D PE + Sbjct: 198 ESV-DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTD----PEVKEI 252 Query: 255 ISRIFVADPATRISIPEIKTHSWF 278 I + + R+SI ++ H++F Sbjct: 253 IEGCIRQNKSERLSIRDLLNHAFF 276 >5TQX-A nrPDB Length = 655 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 102/226 (45%), Gaps = 18/226 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVK--YIERGDKIDENVQREIINHRSLRHPNIV 79 ++ + +G+G FG L + + +A+K +E K E EI + L H N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 80 RFKEVILTPTHLAII--------MEYASGGELYERIC---NAGRFSEDEARFFFQQLLSG 128 + +V P L I+ MEY SGG+L + + N E + + SG Sbjct: 70 KACDV---PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 126 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 + Y H +I HRDLK EN +L + KI D GY+K VGT Y+APE Sbjct: 127 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE 186 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 + + Y + D WS G ++ + G PF +P + + I++ Sbjct: 187 LFENKPYTATV-DYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK 231 >4MYG-A nrPDB Length = 372 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 125/289 (43%), Gaps = 49/289 (16%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRHPNIVRFKEV 84 +GSG +G DK + E VA+K + R + + RE++ + ++H N++ +V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 85 ILTPTHLA------IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + L ++M + ++I FSE++ ++ Q+L G+ Y HS + Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTD--LQKIMGM-EFSEEKIQYLVYQMLKGLKYIHSAGVV 167 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK N ++ LKI DFG ++ + ++ V T Y APEV+L + + Sbjct: 168 HRDLKPGNLAVNED--CELKILDFGLARHA--DAEMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK-------------------- 238 D+WS G + ML G F+ +DY + +IL V Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKG----KDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 279 Query: 239 YSIPDD---------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S+P R SP+ L+ ++ D R++ + TH +F Sbjct: 280 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 328 >3GC9-A nrPDB Length = 370 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 76/313 (24%), Positives = 127/313 (40%), Gaps = 46/313 (14%) Query: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI--- 59 RA L+ + R ++ +GSG +G D ++ VAVK + R + Sbjct: 11 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 70 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFS 114 RE+ + L+H N++ +V T + ++ G +L I + S Sbjct: 71 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKSQALS 129 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 ++ +F QLL G+ Y HS I HRDLK N ++ L+I DFG ++ + + Sbjct: 130 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFGLARQA--DEEM 185 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 V T Y APE++L + + D+WS G + +L G F DY ++RI Sbjct: 186 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS----DYIDQLKRI 241 Query: 235 LSVKYSIPDDI--RIS---------------------------PECCHLISRIFVADPAT 265 + V + ++ +IS P L+ R+ V D Sbjct: 242 MEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQ 301 Query: 266 RISIPEIKTHSWF 278 R+S E H++F Sbjct: 302 RVSAAEALAHAYF 314 >4E7W-A nrPDB Length = 394 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 81/296 (27%), Positives = 130/296 (43%), Gaps = 51/296 (17%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTK-ELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 Y K IG+G+FGV + + KL + + VA+K + + DK +N RE+ R ++HPN+V Sbjct: 42 YTNCKVIGNGSFGV--VFQAKLVESDEVAIKKVLQ-DKRFKN--RELQIMRIVKHPNVVD 96 Query: 81 FKEVILT------PTHLAIIMEYASGGELYERICNAGRFSEDEA--------RFFFQQLL 126 K + L +++EY E + A R + + QLL Sbjct: 97 LKAFFYSNGDKKDEVFLNLVLEYVP-----ETVYRASRHYAKLKQTMPMLLIKLYMYQLL 151 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 ++Y HS+ ICHRD+K +N LLD P+ LK+ DFG +K + S + + Y AP Sbjct: 152 RSLAYIHSIGICHRDIKPQNLLLD-PPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAP 210 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS------VKYS 240 E++ D+WS G + ++ G P E D I ++L +K Sbjct: 211 ELIFGATNYTTNIDIWSTGCVMAELMQGQ-PLFPGESGIDQLVEIIKVLGTPSREQIKTM 269 Query: 241 IPDDI------------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 P+ + R P+ LISR+ P+ R++ E H +F Sbjct: 270 NPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >4AW2-A nrPDB Length = 437 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 70/279 (25%), Positives = 122/279 (43%), Gaps = 23/279 (8%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE------NVQREIIN 69 +H D ++ +K IG G FG +++ K ++ A+K + + + + +R+++ Sbjct: 71 LHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSG 128 + + I +L ++M+Y GG+L + R E+ ARF+ +++ Sbjct: 130 NGDSKW--ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAP 186 + H + HRD+K +N L+D + RL DFG + +S+ VGTP YI+P Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRL--ADFGSCLKLMEDGTVQSSVAVGTPDYISP 245 Query: 187 EVLLRQEYD----GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 E+L E G D WS GV +Y ML G PF Y K + ++ P Sbjct: 246 EILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--KERFQFP 303 Query: 243 DDIRISPECCHLISRIFVADPATRI---SIPEIKTHSWF 278 + E + R + R+ I + K H +F Sbjct: 304 TQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF 342 >4TPT-A nrPDB Length = 303 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/255 (27%), Positives = 115/255 (45%), Gaps = 33/255 (12%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDK-IDENVQREIINHRSLRHPNIVRFKEVIL 86 +G G FG A + K T +++ +K + R D+ + E+ RSL HPN+++F V+ Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 67 Query: 87 TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLEN 146 L ++ EY GG L + + + F + F + + SG++Y HSM I HRDL N Sbjct: 68 KDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHN 127 Query: 147 TLLDGSPAPRLKICDFGYS-----------------KSSVLHSQPK----STVGTPAYIA 185 L+ + + DFG S K L + + VG P ++A Sbjct: 128 CLIKLDKT--VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMA 185 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE-EPRDYRKTIQRILSVKYSIPDD 244 PE+L + YD + D++S G+ L ++ Y DP+ PR + L + +P D Sbjct: 186 PEMLNGKSYD-ETVDIFSFGIVLCEIIGQVY--ADPDCLPRTLDFGLNVKLFWEKFVPTD 242 Query: 245 -----IRISPECCHL 254 ++ CC L Sbjct: 243 CPPAFFPLAAICCRL 257 >1CM8-A nrPDB Length = 367 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 121/296 (40%), Gaps = 50/296 (16%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRHPNI 78 Y ++ +GSG +G D T VA+K + R + + RE+ + +RH N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 79 VRFKEVILTP-------THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 + +V TP T ++M + G ++ + ED +F Q+L G+ Y Sbjct: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 H+ I HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI------ 245 + D+WS G + M+ G F+ D+ ++ I+ V + P + Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGS----DHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 246 -----------------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 SP +L+ ++ V D R++ E H +F Sbjct: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 >2VD5-A nrPDB Length = 412 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 24/278 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV------QREIINHRSL 73 D ++ +K IG G F +++ K T ++ A+K + + D + +R+++ + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYC 132 R I + +L ++MEY GG+L + G R + ARF+ +++ + Sbjct: 121 RW--ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 178 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS--TVGTPAYIAPEVLL 190 H + HRD+K +N LLD +++ DFG +S VGTP Y++PE+L Sbjct: 179 HRLGYVHRDIKPDNILLD--RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 236 Query: 191 RQEYDGKI------ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 D W+ GV Y M G PF Y K + + + D+ Sbjct: 237 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 296 Query: 245 IRISPECCHLISRIFVADPATRI---SIPEIKTHSWFL 279 + E I R+ + P TR+ + +TH +F Sbjct: 297 -GVPEEARDFIQRL-LCPPETRLGRGGAGDFRTHPFFF 332 >3OMV-A nrPDB Length = 307 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/249 (29%), Positives = 118/249 (47%), Gaps = 20/249 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPNIVRFKEV 84 IGSG+FG + + K + VAVK ++ D E Q E+ R RH NI+ F Sbjct: 44 IGSGSFGT--VYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 100 Query: 85 ILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 +T +LAI+ ++ G LY+ + +F + +Q G+ Y H+ I HRD+K Sbjct: 101 -MTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMK 159 Query: 144 LENTLLDGSPAPRLKICDFGYS--KSSVLHSQP-KSTVGTPAYIAPEVLLRQEYD--GKI 198 N L +KI DFG + KS SQ + G+ ++APEV+ Q+ + Sbjct: 160 SNNIFLH--EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 +DV+S G+ LY ++ G P+ R I ++ Y+ PD ++ C + R+ Sbjct: 218 SDVYSYGIVLYELMTGELPYSHINN----RDQIIFMVGRGYASPDLSKLYKNCPKAMKRL 273 Query: 259 FVADPATRI 267 VAD ++ Sbjct: 274 -VADCVKKV 281 >5O0Y-A nrPDB Length = 579 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 107/244 (43%), Gaps = 21/244 (8%) Query: 54 ERGDKIDENVQREIINHRSLRHPNIVRFKEVI-LTPTHLAIIMEYASGGELYERICNAGR 112 E+ + ++ RE H+ L HP IV+ + L ++EY G +L + Sbjct: 326 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL 385 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQ--ICHRDLKLENTLL-DGSPAPRLKICDFGYSK--- 166 SE EAR Q+++ + Y + ++ I H DLK N LL +G+ +KI DFG SK Sbjct: 386 MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD 445 Query: 167 ----SSV----LHSQPKSTVGTPAYIAPEVLLRQEYDGKIA---DVWSCGVTLYVMLVGA 215 +SV L SQ GT Y+ PE + + KI+ DVWS GV Y L G Sbjct: 446 DDSYNSVDGMELTSQ---GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGR 502 Query: 216 YPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 PF + +D + + + + P ++PE I R RI + ++ Sbjct: 503 KPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 276 SWFL 279 + L Sbjct: 563 PYLL 566 >3OHT-A nrPDB Length = 389 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/306 (24%), Positives = 129/306 (42%), Gaps = 48/306 (15%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQREI 67 L+ I +RY + +GSG +G D + +AVK + R + + RE+ Sbjct: 42 LNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYREL 101 Query: 68 INHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICNAGRFSEDEARFFF 122 + ++H N++ +V T L ++ + G +L I + ++D +F Sbjct: 102 RLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLI 160 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGT 180 Q+L G+ Y HS I HRDLK N ++ LKI DFG ++ H+ + T V T Sbjct: 161 YQILRGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLAR----HTDDEMTGYVAT 214 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG--AYPFED------------------ 220 Y APE++L + D+WS G + +L G +P D Sbjct: 215 RWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAS 274 Query: 221 ------PEEPRDYRKTIQRILSVKYSIPDDIRI--SPECCHLISRIFVADPATRISIPEI 272 E R+Y ++ ++ ++ D+ I +P L+ ++ V D RI+ E Sbjct: 275 VISRMPSHEARNYINSLPQMPKRNFA---DVFIGANPLAVDLLEKMLVLDTDKRITASEA 331 Query: 273 KTHSWF 278 H +F Sbjct: 332 LAHPYF 337 >4Y83-A nrPDB Length = 332 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/199 (29%), Positives = 94/199 (47%), Gaps = 14/199 (7%) Query: 26 KDIGS-----GNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 ++IGS G FG L +D TK+ +A K I +D+ ++ RH NI Sbjct: 74 RNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI----PVDQFKPSDVEIQACFRHENIAE 129 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 +L + + ME GG + E++ + G E E + + +L G+ + HS ++ H Sbjct: 130 LYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHH 189 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLRQEYDGKIA 199 D+K N + + A + DFG S PK GT Y++PEV+L + + K A Sbjct: 190 DIKPSNIVFMSTKA---VLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTK-A 245 Query: 200 DVWSCGVTLYVMLVGAYPF 218 D++S G TL M G P+ Sbjct: 246 DIYSLGATLIHMQTGTPPW 264 >3ORP-A nrPDB Length = 311 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 93/214 (43%), Gaps = 15/214 (7%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE----RGDKIDENVQREIINHRS 72 H SDRY+ + +G G L RD VAVK + R +RE N + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 73 LRHPNIVRFKEVILTPTHLA----IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 L HP IV + T I+MEY G L + + G + A Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYI 184 +++ H I HRD+K N ++ + A +K+ DFG ++ S +Q + +GT Y+ Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNA--VKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 +PE D + +DV+S G LY +L G PF Sbjct: 187 SPEQARGDSVDAR-SDVYSLGCVLYEVLTGEPPF 219 >2XS0-A nrPDB Length = 386 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 101/226 (44%), Gaps = 21/226 (9%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLRHPN 77 RY +K IGSG G+ D + + VA+K + R + + +R E++ + + H N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 78 IVRFKEVILTPTH-------LAIIMEYASGGELYERICNAGRFSEDEAR--FFFQQLLSG 128 I+ V TP + I+ME +C + D R + Q+L G Sbjct: 87 IIGLLNV-FTPQKSLEEFQDVYIVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCG 140 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 + + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMVPFVVTRYYRAPEV 198 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 +L Y + D+WS G + M+ G F + + K I+++ Sbjct: 199 ILGMGYKENV-DIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 243 >2I6L-A nrPDB Length = 320 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 87/311 (27%), Positives = 124/311 (39%), Gaps = 51/311 (16%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIV 79 RY +K +G G G+ D + VA+K I D + ++ REI R L H NIV Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIV 71 Query: 80 RFKEVILTPTHLAIIMEYASGGEL-------------YERICNAGRFSEDEARFFFQQLL 126 + E IL P+ + + S EL + G E+ AR F QLL Sbjct: 72 KVFE-ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL 130 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPA 182 G+ Y HS + HRDLK N ++ + LKI DFG ++ H K + T Sbjct: 131 RGLKYIHSANVLHRDLKPANLFIN-TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW 189 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE-----------PRDYRKTI 231 Y +P +LL K D+W+ G ML G F E P + + Sbjct: 190 YRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDR 249 Query: 232 QRILSVKYSIPDDIR----------------ISPECCHLISRIFVADPATRISIPEIKTH 275 Q +LSV IP IR IS E + +I P R++ E +H Sbjct: 250 QELLSV---IPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSH 306 Query: 276 SWF-LKNLPAD 285 + + + P D Sbjct: 307 PYMSIYSFPMD 317 >6DBM-A nrPDB Length = 318 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/221 (33%), Positives = 109/221 (49%), Gaps = 25/221 (11%) Query: 9 GPLDMPIMHDSDRY-DFVKDIGSGNFGVARLM----RDKLTKELVAVKYIER--GDKIDE 61 GP D + H RY ++D+G G+FG L + T E+VAVK ++ G + Sbjct: 21 GPGDPTVFHK--RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRS 78 Query: 62 NVQREIINHRSLRHPNIVRFKEVI--LTPTHLAIIMEYASGGELYERICNAGRFSEDEAR 119 ++EI R+L H +I+++K L ++MEY G L + + R S A+ Sbjct: 79 GWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL---PRHSIGLAQ 135 Query: 120 F--FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQP 174 F QQ+ G++Y HS HRDL N LLD +KI DFG +K+ + + Sbjct: 136 LLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRV 193 Query: 175 KSTVGTPA-YIAPEVLLRQEYDGKIA-DVWSCGVTLYVMLV 213 + +P + APE L +EY A DVWS GVTLY +L Sbjct: 194 REDGDSPVFWYAPECL--KEYKFYYASDVWSFGVTLYELLT 232 >3E7O-A nrPDB Length = 360 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 100/220 (45%), Gaps = 9/220 (4%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLRHPN 77 RY +K IGSG G+ D + VAVK + R + + +R E++ + + H N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYE-RICNAGRFSEDEAR--FFFQQLLSGVSYCHS 134 I+ V L + EL + +C D R + Q+L G+ + HS Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHS 142 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK N ++ LKI DFG ++++ + V T Y APEV+L Y Sbjct: 143 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGY 200 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 + D+WS G + ++ G+ F+ + + K I+++ Sbjct: 201 KENV-DIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQL 239 >4Y93-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 104/227 (45%), Gaps = 22/227 (9%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV 63 AP T G D F+K++G+G FGV + + + + VA+K I+ G ++ Sbjct: 172 APSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEF 230 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 E +L H +V+ V + II EY + G C E RF Q Sbjct: 231 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQ 284 Query: 124 QLL-------SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 QLL + Y S Q HRDL N L++ +K+ DFG ++ VL + S Sbjct: 285 QLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGMTR-YVLDDEYTS 341 Query: 177 TVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFE 219 + G+ + +PEVL+ ++ K +D+W+ GV ++ + +G P+E Sbjct: 342 STGSKFPVKWASPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYE 387 >4XI2-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 103/227 (45%), Gaps = 22/227 (9%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV 63 AP T G D F+K++G+G FGV + + + + VA+K I G ++ Sbjct: 171 APSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSEDEF 229 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 E +L H +V+ V + II EY + G C E RF Q Sbjct: 230 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQ 283 Query: 124 QLL-------SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 QLL + Y S Q HRDL N L++ +K+ DFG S+ VL + S Sbjct: 284 QLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTS 340 Query: 177 TVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFE 219 +VG+ + PEVL+ ++ K +D+W+ GV ++ + +G P+E Sbjct: 341 SVGSKFPVRWSPPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYE 386 >2W1I-A nrPDB Length = 326 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 104/213 (48%), Gaps = 17/213 (7%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMR-DKL---TKELVAVKYIERG-DKIDENVQREII 68 P + F++ +G GNFG + R D L T E+VAVK ++ ++ + +REI Sbjct: 35 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 94 Query: 69 NHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQL 125 +SL+H NIV++K V + +L +IMEY G L + + + R + + Q+ Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 154 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--- 182 G+ Y + + HRDL N L++ R+KI DFG +K + + V P Sbjct: 155 CKGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTK-VLPQDKEYYKVKEPGESP 211 Query: 183 --YIAPEVLLRQEYDGKIADVWSCGVTLYVMLV 213 + APE L ++ +DVWS GV LY + Sbjct: 212 IFWYAPESLTESKFS-VASDVWSFGVVLYELFT 243 >3E3P-A nrPDB Length = 360 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 19/210 (9%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 DR+ + G G FG +L ++K T VA+K + + + + + + L HPNIV Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 80 RFKEVILT-------PTHLAIIMEYASGGELYERICNAGRFSEDEA------RFFFQQLL 126 + + T +L ++MEY + R C + A + F QL+ Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCR-NYYRRQVAPPPILIKVFLFQLI 139 Query: 127 SGVSYCH--SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 + H S+ +CHRD+K N L++ + LK+CDFG +K + + + Y Sbjct: 140 RSIGCLHLPSVNVCHRDIKPHNVLVNEADG-TLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVG 214 APE++ ++ D+WS G M++G Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLG 228 >6E4F-A nrPDB Length = 290 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 99/207 (47%), Gaps = 22/207 (10%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 F+K++G+G FGV + + + + VA+K I+ G ++ E +L H +V+ Sbjct: 35 FLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYG 93 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLL-------SGVSYCHSMQ 136 V + II EY + G C E RF QQLL + Y S Q Sbjct: 94 VCTKQRPIFIITEYMANG------CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 147 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQE 193 HRDL N L++ +K+ DFG S+ VL + S+VG+ + PEVL+ + Sbjct: 148 FLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPFE 219 + K +D+W+ GV ++ + +G P+E Sbjct: 205 FSSK-SDIWAFGVLMWEIYSLGKMPYE 230 >5AWM-A nrPDB Length = 394 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/308 (25%), Positives = 125/308 (40%), Gaps = 62/308 (20%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 RY ++ IGSG G+ D +T++ VA+K + R +NV +R + +V Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPF---QNVTHAKRAYREFKLMKLVN 101 Query: 81 FKEVI-----LTPTH-------LAIIMEYASGGELYERICNAGRFSEDEAR--FFFQQLL 126 K +I TP + ++ME +C + D R + Q+L Sbjct: 102 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQML 156 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + HS I HRDLK N ++ LKI DFG ++++ V T Y AP Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAP 214 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS---------- 236 EV+L Y + D+WS G + M+ G F + + K I+++ + Sbjct: 215 EVILGMGYTENV-DIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 237 -------------VKYS----IPDDI----------RISPECCHLISRIFVADPATRISI 269 YS PD + R + + +L+S++ V DP RIS+ Sbjct: 274 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 333 Query: 270 PEIKTHSW 277 E H + Sbjct: 334 DEALKHEY 341 >2Y4I-B nrPDB Length = 319 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 103/210 (49%), Gaps = 24/210 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYI--ERGDKID-ENVQREIINHRSLRHPNIVRFKEV 84 IG G FG ++ + E VA++ I ER ++ + +RE++ +R RH N+V F Sbjct: 41 IGKGRFG--QVYHGRWHGE-VAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 85 ILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 ++P HLAII G LY + +A ++ R Q+++ G+ Y H+ I H+DLK Sbjct: 98 CMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLK 157 Query: 144 LENTLLDGSPAPRLKICDFG-YSKSSVLHSQPKS-----TVGTPAYIAPEVLLRQEYD-- 195 +N D ++ I DFG +S S VL + + G ++APE++ + D Sbjct: 158 SKNVFYDNG---KVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTE 214 Query: 196 ------GKIADVWSCGVTLYVMLVGAYPFE 219 K +DV++ G Y + +PF+ Sbjct: 215 EDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >6DBN-A nrPDB Length = 316 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/202 (31%), Positives = 102/202 (50%), Gaps = 16/202 (7%) Query: 25 VKDIGSGNFGVARLMR----DKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPNI 78 ++D+G G+FG L R T E VAVK + E G ++++EI R+L H NI Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENI 99 Query: 79 VRFKEVIL--TPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSM 135 V++K + + +IME+ G L E + N + + + + Q+ G+ Y S Sbjct: 100 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 159 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPA-YIAPEVLLR 191 Q HRDL N L++ ++KI DFG +K + + K +P + APE L++ Sbjct: 160 QYVHRDLAARNVLVESEH--QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 192 QEYDGKIADVWSCGVTLYVMLV 213 ++ +DVWS GVTL+ +L Sbjct: 218 SKFY-IASDVWSFGVTLHELLT 238 >1ZXE-A nrPDB Length = 303 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 77/283 (27%), Positives = 118/283 (41%), Gaps = 41/283 (14%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVIL- 86 +G G FG R+ L A+K I ++ + E++ SL H +VR+ L Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLE 73 Query: 87 ------------TPTHLAIIMEYASGGELYERICNAGRFSE-DEARFFFQQLLSGVSYCH 133 + L I MEY LY+ I + + DE F+Q+L +SY H Sbjct: 74 RRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIH 133 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-------VLHSQP--------KSTV 178 S I HR+LK N +D S +KI DFG +K+ L SQ S + Sbjct: 134 SQGIIHRNLKPMNIFIDES--RNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAI 191 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GT Y+A EVL + + D++S G+ + M+ YPF E + ++++ SV Sbjct: 192 GTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVN---ILKKLRSVS 245 Query: 239 YSIP---DDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 P DD ++ E +I + DP R + W Sbjct: 246 IEFPPDFDDNKMKVE-KKIIRLLIDHDPNKRPGARTLLNSGWL 287 >1G3N-A nrPDB Length = 326 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 121/293 (41%), Gaps = 39/293 (13%) Query: 21 RYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYI-----ERGDKIDENVQREIINH-RSL 73 +Y+ V +IG G +G RD K VA+K + E G + + ++ H + Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 74 RHPNIVRFKEVILTP-----THLAIIMEYASG--GELYERICNAGRFSEDEARFFFQQLL 126 HPN+VR +V T L ++ E+ +++ G +E FQ LL Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LL 130 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + HS ++ HRDLK +N L+ S ++K+ DFG ++ S V T Y AP Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYSIPDDI 245 EVLL+ Y + D+WS G M F + K + I L + P D+ Sbjct: 189 EVLLQSSYATPV-DLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 246 RISPECCH--------------------LISRIFVADPATRISIPEIKTHSWF 278 + + H L+ + +PA RIS +H +F Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 >3N9X-A nrPDB Length = 432 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/228 (29%), Positives = 101/228 (44%), Gaps = 34/228 (14%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKID-ENVQREIINHRS 72 +H D Y IG G++G L DK T++ VA+K + R D ID + + REI Sbjct: 22 VHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNR 81 Query: 73 LRHPNIVRFKEVI-----LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLS 127 L+ I+R ++I L L I++E A +L + +E+ + LL Sbjct: 82 LKSDYIIRLYDLIIPDDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEEHIKTILYNLLL 140 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-------------------- 167 G ++ H I HRDLK N LL+ + +K+CDFG +++ Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCS--VKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 168 ---SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 L Q S V T Y APE++L QE K D+WS G +L Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >3IO7-A nrPDB Length = 313 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 102/203 (50%), Gaps = 17/203 (8%) Query: 24 FVKDIGSGNFGVARLMR-DKL---TKELVAVKYIERG-DKIDENVQREIINHRSLRHPNI 78 F++ +G GNFG + R D L T E+VAVK ++ ++ + +REI +SL+H NI Sbjct: 32 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 91 Query: 79 VRFKEVILTPT--HLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSM 135 V++K V + +L +IMEY G L + + + R + + Q+ G+ Y + Sbjct: 92 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 151 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLL 190 + HRDL N L++ R+KI DFG +K + + V P + APE L Sbjct: 152 RYIHRDLATRNILVENE--NRVKIGDFGLTK-VLPQDKEYYKVKEPGESPIFWYAPESLT 208 Query: 191 RQEYDGKIADVWSCGVTLYVMLV 213 ++ +DVWS GV LY + Sbjct: 209 ESKFS-VASDVWSFGVVLYELFT 230 >3ALO-A nrPDB Length = 327 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 72/267 (26%), Positives = 116/267 (43%), Gaps = 19/267 (7%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREI-----INHRSLRHPNIVRF 81 +IG G +G M K + +++AVK I +DE Q+++ + RS P IV+F Sbjct: 29 EIGRGAYGSVNKMVHKPSGQIMAVKRIR--STVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 82 KEVILTPTHLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLLSGVSYCH---SMQ 136 + I ME S + Y+ + + E L + + H +++ Sbjct: 87 YGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLK 146 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL----LRQ 192 I HRD+K N LLD S +K+CDFG S V G Y+APE + RQ Sbjct: 147 IIHRDIKPSNILLDRSG--NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQ 204 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 YD + +DVWS G+TLY + G +P+ D + + + S ++ SP Sbjct: 205 GYDVR-SDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFI 263 Query: 253 HLISRIFVADPATRISIPEIKTHSWFL 279 + ++ D + R E+ H + L Sbjct: 264 NFVNLCLTKDESKRPKYKELLKHPFIL 290 >3VN9-A nrPDB Length = 340 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 125/272 (45%), Gaps = 19/272 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREI-----INHRSL 73 +D + + ++G G +GV MR + +++AVK I ++ Q+ + I+ R++ Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLLMDLDISMRTV 107 Query: 74 RHPNIVRFKEVILTPTHLAIIMEY--ASGGELYERICNAGR-FSEDEARFFFQQLLSGVS 130 P V F + + I ME S + Y+++ + G+ ED ++ + Sbjct: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 Query: 131 YCHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 + HS + + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 168 HLHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 Query: 190 ---LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 L Q+ +D+WS G+T+ + + +P++ P +++ Q + +P D + Sbjct: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-K 282 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S E S+ + R + PE+ H +F Sbjct: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >3MIA-A nrPDB Length = 351 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 84/335 (25%), Positives = 143/335 (42%), Gaps = 53/335 (15%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREI 67 ++ P + +Y+ + IG G FG R + T + VA+K + + REI Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 68 INHRSLRHPNIVRFKEVILTPTH--------LAIIMEYASGGELYERICNA-GRFSEDEA 118 + L+H N+V E+ T + ++ ++ +L + N +F+ E Sbjct: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVL--HSQP 174 + Q LL+G+ Y H +I HRD+K N L+ DG LK+ DFG +++ L +SQP Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQP 182 Query: 175 K---STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVM-------------------- 211 + V T Y PE+LL + G D+W G + M Sbjct: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 Query: 212 -LVGAYPFEDPEEPRDYR--KTIQRILSVKYSIPDDIRI---SPECCHLISRIFVADPAT 265 L G+ E +Y + ++ + K + D ++ P LI ++ V DPA Sbjct: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 Query: 266 RISIPEIKTHSWFLKN-LPADL--MNESNTGSQFQ 297 RI + H +F + +P+DL M ++ S F+ Sbjct: 303 RIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 >3RP9-A nrPDB Length = 458 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 100/229 (43%), Gaps = 39/229 (17%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKID-ENVQREIINHRSLRHP 76 DRY+ IG+G++G DKL K +VA+K I R D ID + + REI L H Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 77 NIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 ++V+ ++++ L +++E A + + +E + LL GV Y Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADS-DFKKLFRTPVYLTELHIKTLLYNLLVGVKY 171 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS------------------------ 167 HS I HRDLK N L++ + +K+CDFG +++ Sbjct: 172 VHSAGILHRDLKPANCLVNQDCS--VKVCDFGLARTVDYPENGNSQLPISPREDDMNLVT 229 Query: 168 ----SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 L Q V T Y APE++L QE + DVWS G +L Sbjct: 230 FPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >4JLC-A nrPDB Length = 657 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/229 (30%), Positives = 103/229 (44%), Gaps = 20/229 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQ-REIINHRSLRHPNIVRF--KE 83 +G G R K T +L AVK + +VQ RE + L H NIV+ E Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 75 Query: 84 VILTPTHLAIIMEYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY E NA E E + ++ G+++ I HR Sbjct: 76 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 135 Query: 141 DLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQ 192 D+K N + DG K+ DFG ++ Q S GT Y+ P++ +LR+ Sbjct: 136 DIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 193 Query: 193 EYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 ++ G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 194 DHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 242 >3FME-A nrPDB Length = 290 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 125/272 (45%), Gaps = 19/272 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREI-----INHRSL 73 +D + + ++G G +GV MR + +++AVK I ++ Q+ + I+ R++ Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLLMDLDISMRTV 63 Query: 74 RHPNIVRFKEVILTPTHLAIIMEY--ASGGELYERICNAGR-FSEDEARFFFQQLLSGVS 130 P V F + + I ME S + Y+++ + G+ ED ++ + Sbjct: 64 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 131 YCHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 + HS + + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 124 HLHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERI 181 Query: 190 ---LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 L Q+ +D+WS G+T+ + + +P++ P +++ Q + +P D + Sbjct: 182 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-K 238 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S E S+ + R + PE+ H +F Sbjct: 239 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >5Y86-A nrPDB Length = 588 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 73/225 (32%), Positives = 101/225 (44%), Gaps = 24/225 (10%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIIN 69 + +P H + RY+ +K IG G+FG VAR+ KL ++ VA+K + + EI Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEI-- 254 Query: 70 HRSLRH---------PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEA 118 R L H N++ E H+ + E S +LYE I FS Sbjct: 255 -RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLV 312 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST- 177 R F Q +L + H +I H DLK EN LL K+ DFG SS Q T Sbjct: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTY 369 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGA--YPFED 220 + + Y APE++L Y I D+WS G L +L G +P ED Sbjct: 370 IQSRFYRAPEIILGSRYSTPI-DIWSFGCILAELLTGQPLFPGED 413 >4EUU-A nrPDB Length = 319 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/219 (30%), Positives = 101/219 (46%), Gaps = 20/219 (9%) Query: 40 RDKLTKELVAVKYIERGDKIDE-NVQ-REIINHRSLRHPNIVRF--KEVILTPTHLAIIM 95 R K T +L A+K + +VQ RE + L H NIV+ E T H +IM Sbjct: 29 RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIM 88 Query: 96 EYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--- 149 E+ G LY E NA E E + ++ G+++ I HR++K N + Sbjct: 89 EFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIG 148 Query: 150 -DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQEYD---GKIADV 201 DG K+ DFG ++ Q S GT Y+ P++ +LR+++ G D+ Sbjct: 149 EDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDL 206 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 207 WSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >6NT9-A nrPDB Length = 742 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 103/229 (44%), Gaps = 20/229 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQ-REIINHRSLRHPNIVRF--KE 83 +G G R K T +L A+K + +VQ RE + L H NIV+ E Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 Query: 84 VILTPTHLAIIMEYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY E NA E E + ++ G+++ I HR Sbjct: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 Query: 141 DLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQ 192 ++K N + DG K+ DFG ++ Q S GT Y+ P++ +LR+ Sbjct: 135 NIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 Query: 193 EYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 ++ G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 >4E20-A nrPDB Length = 290 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 22/204 (10%) Query: 25 VKDIGSGNFGVARLM----RDKLTKELVAVKYIERG--DKIDENVQREIINHRSLRHPNI 78 ++D+G G+FG L + T E+VAVK ++ G ++ QREI R+L H +I Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHI 72 Query: 79 VRFKEVI--LTPTHLAIIMEYASGGELYE---RICNAGRFSEDEARFFFQQLLSGVSYCH 133 V++K + ++MEY G L + R C + F QQ+ G++Y H Sbjct: 73 VKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC----VGLAQLLLFAQQICEGMAYLH 128 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQPKSTVGTPA-YIAPEVL 189 + HR L N LLD +KI DFG +K+ + + + +P + APE L Sbjct: 129 AQHYIHRALAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 186 Query: 190 LRQEYDGKIADVWSCGVTLYVMLV 213 ++ +DVWS GVTLY +L Sbjct: 187 KECKFY-YASDVWSFGVTLYELLT 209 >4OLI-A nrPDB Length = 645 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/204 (32%), Positives = 102/204 (50%), Gaps = 22/204 (10%) Query: 25 VKDIGSGNFGVARLM----RDKLTKELVAVKYIER--GDKIDENVQREIINHRSLRHPNI 78 ++D+G G+FG L + T E+VAVK ++ G + ++EI R+L H +I Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI 417 Query: 79 VRFKEVI--LTPTHLAIIMEYASGGELYERICNAGRFSEDEARF--FFQQLLSGVSYCHS 134 +++K L ++MEY G L + + R S A+ F QQ+ G++Y HS Sbjct: 418 IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQICEGMAYLHS 474 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQPKSTVGTPA-YIAPEVLL 190 HR+L N LLD +KI DFG +K+ + + + +P + APE L Sbjct: 475 QHYIHRNLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL- 531 Query: 191 RQEYDGKIA-DVWSCGVTLYVMLV 213 +EY A DVWS GVTLY +L Sbjct: 532 -KEYKFYYASDVWSFGVTLYELLT 554 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 61/157 (38%), Gaps = 17/157 (10%) Query: 123 QQLLSGVSYCHSM-----QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST 177 QQL S +SY + +C R++ L L +P +K+ D G ++ + Sbjct: 174 QQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVER 233 Query: 178 VGTPAYIAPEVLLRQEYDGKIA-DVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRIL 235 + ++APE L A D W G TL + G P + P + QR Sbjct: 234 I---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQS-RSPSEKEHFYQR-- 287 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 ++ +P+ P+ L S+ +P R S I Sbjct: 288 --QHRLPEP--SCPQLATLTSQCLTYEPTQRPSFRTI 320 >3FI2-A nrPDB Length = 353 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 118/299 (39%), Gaps = 45/299 (15%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRHPN 77 RY +K IGSG G+ D + VA+K + R + RE++ + + H N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYE-RICNAGRFSEDEAR--FFFQQLLSGVSYCHS 134 I+ V L + EL + +C + D R + Q+L G+ + HS Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 144 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 145 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 202 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-------------------- 234 + D+WS G + M+ F + + K I+++ Sbjct: 203 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 261 Query: 235 -------LSVKYSIPDDI---------RISPECCHLISRIFVADPATRISIPEIKTHSW 277 L+ PD + + + L+S++ V DPA RIS+ + H + Sbjct: 262 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 320 >4EUT-A nrPDB Length = 396 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 103/229 (44%), Gaps = 20/229 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQ-REIINHRSLRHPNIVRF--KE 83 +G G R K T +L A+K + +VQ RE + L H NIV+ E Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 84 VILTPTHLAIIMEYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY E NA E E + ++ G+++ I HR Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 136 Query: 141 DLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQ 192 ++K N + DG K+ DFG ++ Q S GT Y+ P++ +LR+ Sbjct: 137 NIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 193 EYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 ++ G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 195 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 >4C59-A nrPDB Length = 340 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 121/277 (43%), Gaps = 53/277 (19%) Query: 25 VKDIGSGN-FGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF-- 81 +D+GSG + + RL+ ++ K ++ + K+ HPNIV+F Sbjct: 46 AQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSG-------------HPNIVQFCS 92 Query: 82 ------KEVILTPTHLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 +E ++ E G E +++ + G S D F Q V + H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 134 SMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-------SQPKSTV------ 178 + I HRDLK+EN LL S +K+CDFG S +++ H +Q ++ V Sbjct: 153 RQKPPIIHRDLKVENLLL--SNQGTIKLCDFG-SATTISHYPDYSWSAQRRALVEEEITR 209 Query: 179 -GTPAYIAPEVL-LRQEYD-GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 TP Y PE++ L + G+ D+W+ G LY++ +PFED + RI+ Sbjct: 210 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK--------LRIV 261 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + KYSIP LI + +P R+SI E+ Sbjct: 262 NGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >1JNK-A nrPDB Length = 423 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 120/299 (40%), Gaps = 45/299 (15%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLRHPN 77 RY +K IGSG G+ D + VA+K + R + + +R E++ + + H N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYE-RICNAGRFSEDEAR--FFFQQLLSGVSYCHS 134 I+ V L + EL + +C + D R + Q+L G+ + HS Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-------------------- 234 + D+WS G + M+ F + + K I+++ Sbjct: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Query: 235 -------LSVKYSIPDDI---------RISPECCHLISRIFVADPATRISIPEIKTHSW 277 L+ PD + + + L+S++ V DPA RIS+ + H + Sbjct: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 >4QNY-A nrPDB Length = 354 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 94/343 (27%), Positives = 144/343 (41%), Gaps = 57/343 (16%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYIERGDKIDEN 62 A + L + DRY + IG+G++GV RD K LVA+K + + E Sbjct: 4 ATKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNK-----EI 58 Query: 63 VQREIINHRSLRH---------PNIVRFKEVILTPT------HLAIIMEYASGGELYERI 107 + I+ R LR NI+ + ILTP H I+M+ +L + + Sbjct: 59 FEEVILAKRILREIKLLAHFNDDNIIGLRN-ILTPEDPENFDHFYIVMDIMET-DLKQVL 116 Query: 108 CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS 167 + +E +FF Q L + HS + HRD+ N L++ + LKICDFG +K Sbjct: 117 RSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCD--LKICDFGLAKE 174 Query: 168 SVLHSQPKST-VGTPAYIAPEVLLR-QEYDGKIADVWSCGVTLYVMLVGAYP-FEDPEEP 224 + + V Y APE+++ ++Y +I DVW G L +L G+ P F+ + Sbjct: 175 ENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQI-DVWGIGCILGELL-GSRPLFQGKDRV 232 Query: 225 RDYRKTI-------------------QRILSVKYSIPD-DIR-----ISPECCHLISRIF 259 K + Q+ L K P D R SPE L+ + Sbjct: 233 NQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHML 292 Query: 260 VADPATRISIPEIKTHSWFLKNLPADL-MNESNTGSQFQEPEQ 301 V +P RI++ + H FL+ L D N S +F E EQ Sbjct: 293 VFNPKRRITVLQAMRHP-FLEQLHDDADDNLSYALFRFDENEQ 334 >4O2Z-A nrPDB Length = 377 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 133/312 (42%), Gaps = 52/312 (16%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKY---IERGDKIDEN 62 V+ P ++P +Y +K +G G +G+A D T E V++K + R + + Sbjct: 36 VSGSPFEVP-----SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 63 VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELY---------ERICNAGR- 112 V REI R H N++ IL P + EY S ++Y + R Sbjct: 91 VLREIDMMRFFHHENLLNVVN-ILPP----LKREYHSFEDVYVVTPLMDVDMNVVLRSRQ 145 Query: 113 -FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVL 170 E ++F Q+L G+ Y HS + HRDLK N + + S LKI DFG S+S V Sbjct: 146 VLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNIS--CELKIIDFGLSRSVDVP 203 Query: 171 HSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVM-----------------LV 213 +S+ V T Y PE+LL D+WS G M ++ Sbjct: 204 YSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMI 263 Query: 214 GAYPFEDPEEPRDYRKTIQRI-------LSVKYSIPDDIRISPECCHLISRIFVADPATR 266 + + P ++R+ ++++ L++ +P + + E +S+++ DP+ R Sbjct: 264 AQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVP-GLAGNTEGIDFLSKMWTLDPSKR 322 Query: 267 ISIPEIKTHSWF 278 + ++ H + Sbjct: 323 PTAADMLAHPYL 334 >2PMN-X nrPDB Length = 348 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 52/172 (30%), Positives = 80/172 (46%), Gaps = 21/172 (12%) Query: 123 QQLLSGVSYCHSMQ-ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 + +L+ SY H+ + ICHRD+K N L+D + R+K+ DFG S+ V + K + GT Sbjct: 158 KSVLNSFSYIHNEKNICHRDVKPSNILMDKNG--RVKLSDFGESEYMV-DKKIKGSRGTY 214 Query: 182 AYIAPEVLLRQE-YDGKIADVWSCGVTLYVMLVGAYPF---------------EDPEEPR 225 ++ PE + Y+G D+WS G+ LYVM PF ++ E P Sbjct: 215 EFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPL 274 Query: 226 DYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSW 277 D R L+ K S + +S E + +PA RI+ + H W Sbjct: 275 D-RNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEW 325 >2WO6-A nrPDB Length = 382 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 68/223 (30%), Positives = 96/223 (43%), Gaps = 14/223 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREII------NHRSL 73 DRY+ IG G+FG D++ +E VA+K I+ Q E+ H + Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYE--RICNAGRFSEDEARFFFQQLLSGVSY 131 IV K + HL ++ E S LY+ R N S + R F QQ+ + + + Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLS-YNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 132 CHS--MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 + + I H DLK EN LL +KI DFG S L + + + Y +PEVL Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFG--SSCQLGQRIYQYIQSRFYRSPEVL 230 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 L YD I D+WS G L M G F E K ++ Sbjct: 231 LGMPYDLAI-DMWSLGCILVEMHTGEPLFSGANEVDQMNKIVE 272 >4YHJ-A nrPDB Length = 584 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 103/227 (45%), Gaps = 11/227 (4%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL 73 P+ ++ R+ V +G G FG + + T ++ A K +++ + +N + + Sbjct: 181 PVTKNTFRHYRV--LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRI 238 Query: 74 RHPNIVRFKEVIL----TPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLS 127 RF + T L +++ +GG+L I N G F E A F+ +L Sbjct: 239 LEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 G+ +I +RDLK EN LLD ++I D G + + + VGT Y+APE Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDR--GHIRISDLGLATEIPEGQRVRGRVGTVGYMAPE 356 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 V+ ++Y D W G +Y M+ G PF+ +E + + QRI Sbjct: 357 VVNNEKYTFS-PDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI 402 >2Y6O-A nrPDB Length = 291 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 94/208 (45%), Gaps = 18/208 (8%) Query: 26 KDIGSGNFG---VARLMRDKLTKELVAVKYIERG--DKIDENVQREIINHRSLRHPNIVR 80 K IG G FG RL + VA+K ++ G DK + E HPNI+ Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIH 79 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ + II EY G L + N GRF+ + + + SG+ Y M H Sbjct: 80 LEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVH 139 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLLRQE 193 RDL N L++ + K+ DFG S+ VL P++ T + APE + ++ Sbjct: 140 RDLAARNILVNSNLV--CKVSDFGMSR--VLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 195 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPFED 220 + +DVWS G+ ++ VM G P+ D Sbjct: 196 FTSA-SDVWSYGIVMWEVMSYGERPYWD 222 >3HMP-A nrPDB Length = 342 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 131/302 (43%), Gaps = 51/302 (16%) Query: 22 YDFVKDIGSGNFG-VARLMRDKLTKELVAVKYI---ERGDKIDENVQREI--INHRSLRH 75 Y +K IGSG V +++ +K K++ A+KY+ E ++ ++ + EI +N Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 187 I H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 175 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 188 VL----------LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + + +DVWS G LY M G PF ++ + + I+ Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 283 Query: 238 KYSI--PD----DIRISPECCHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNES 290 + I PD D++ +CC DP RISIPE+ H + ++ P + M + Sbjct: 284 NHEIEFPDIPEKDLQDVLKCC------LKRDPKQRISIPELLAHPYVQIQTHPVNQMAKG 337 Query: 291 NT 292 T Sbjct: 338 TT 339 >5ZTN-A nrPDB Length = 429 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 94/224 (41%), Gaps = 13/224 (5%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH 70 + +P H + RY+ +K IG G+FG D + VA+K + + EI Sbjct: 88 VQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRIL 147 Query: 71 RSLRHP------NIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFF 122 LR N++ E H+ + E S LYE I FS R F Sbjct: 148 EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFA 206 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 182 +L + H +I H DLK EN LL +K+ DFG S H + + + + Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTYIQSRF 264 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRD 226 Y APEV+L Y G D+WS G L +L G YP E+ D Sbjct: 265 YRAPEVILGARY-GMPIDMWSLGCILAELLTG-YPLLPGEDEGD 306 >4P5Q-A nrPDB Length = 361 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 102/209 (48%), Gaps = 24/209 (11%) Query: 26 KDIGSGNFGVARLMRDKL--TKEL-VAVKYIERGDKIDENVQREIINHRSLR----HPNI 78 K +G+G FG R KL KE+ VA+K ++ G E +R+ + S+ HPNI Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVG--YTEKQRRDFLGEASIMGQFDHPNI 96 Query: 79 VRFKEVILTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +R + V+ + I+ EY G L + R +A +F+ + + + SG+ Y M Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDA-QFTVIQLVGMLRGIASGMKYLSDMG 155 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLL 190 HRDL N L++ + K+ DFG S+ VL P++ T + +PE + Sbjct: 156 YVHRDLAARNILINSNLV--CKVSDFGLSR--VLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 191 RQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 +++ +DVWS G+ L+ VM G P+ Sbjct: 212 YRKFTSA-SDVWSYGIVLWEVMSYGERPY 239 >6O8B-A nrPDB Length = 665 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 102/229 (44%), Gaps = 20/229 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQ-REIINHRSLRHPNIVRF--KE 83 +G G R K T +L A+K + +VQ RE + L H NIV+ E Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 82 Query: 84 VILTPTHLAIIMEYASGGELY---ERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY E NA E E + ++ G+++ I HR Sbjct: 83 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 142 Query: 141 DLKLENTLL----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV----LLRQ 192 ++K N + DG K+ DFG ++ Q GT Y+ P++ +LR+ Sbjct: 143 NIKPGNIMRVIGEDGQSV--YKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRK 200 Query: 193 EYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 ++ G D+WS GVT Y G+ PF E PR ++ + +I++ K Sbjct: 201 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 249 >6GVJ-A nrPDB Length = 429 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 131/302 (43%), Gaps = 51/302 (16%) Query: 22 YDFVKDIGSGNFG-VARLMRDKLTKELVAVKYI---ERGDKIDENVQREI--INHRSLRH 75 Y +K IGSG V +++ +K K++ A+KY+ E ++ ++ + EI +N Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 203 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 187 I H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 263 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 188 VL----------LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + + +DVWS G LY M G PF ++ + + I+ Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 371 Query: 238 KYSI--PD----DIRISPECCHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNES 290 + I PD D++ +CC DP RISIPE+ H + ++ P + M + Sbjct: 372 NHEIEFPDIPEKDLQDVLKCC------LKRDPKQRISIPELLAHPYVQIQTHPVNQMAKG 425 Query: 291 NT 292 T Sbjct: 426 TT 427 >2VWV-A nrPDB Length = 302 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 28 IGSGNFG---VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----RHPNIVR 80 IG+G FG RL + VA+K ++ G E +RE ++ S+ HPNI+R Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGG--YTERQRREFLSEASIMGQFEHPNIIR 81 Query: 81 FKEVILTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + V+ + I+ E+ G L + R+ N G+F+ + + + SG+ Y M Sbjct: 82 LEGVVTNSMPVMILTEFMENGALDSFLRL-NDGQFTVIQLVGMLRGIASGMRYLAEMSYV 140 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPA---YIAPEVLLRQ 192 HRDL N L++ + K+ DFG S+ +S S++G + APE + + Sbjct: 141 HRDLAARNILVNSNLV--CKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFR 198 Query: 193 EYDGKIADVWSCGVTLY-VMLVGAYPFED 220 ++ +D WS G+ ++ VM G P+ D Sbjct: 199 KFTSA-SDAWSYGIVMWEVMSFGERPYWD 226 >2WTK-B nrPDB Length = 373 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 18/215 (8%) Query: 22 YDFVKDIGSG--NFGVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSLRHP 76 Y+ + IG G + L R K T E V V+ I +E V Q E+ + HP Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCHS 134 NIV ++ + L ++ + + G + IC +E + Q +L + Y H Sbjct: 71 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 130 Query: 135 MQICHRDLKLENTLL--DGSP-----APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 M HR +K + L+ DG L + G + V+H PK +V +++PE Sbjct: 131 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG-QRQRVVHDFPKYSVKVLPWLSPE 189 Query: 188 VLLR--QEYDGKIADVWSCGVTLYVMLVGAYPFED 220 VL + Q YD K +D++S G+T + G PF+D Sbjct: 190 VLQQNLQGYDAK-SDIYSVGITACELANGHVPFKD 223 >3NIE-A nrPDB Length = 429 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 95/227 (41%), Gaps = 37/227 (16%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKID-ENVQREIINHRSLRHP 76 D Y+ IG G++G L DK + VA+K + R D ID + + REI L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 77 NIVRFKEVI-----LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 I+R ++I L L I++E A +L + +E + LL G + Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS------------------------ 167 H I HRDLK N LL+ + +KICDFG +++ Sbjct: 147 IHESGIIHRDLKPANCLLNQDCS--VKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 168 --SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 L Q S V T Y APE++L QE D+WS G +L Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >5AP3-A nrPDB Length = 313 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 131/302 (43%), Gaps = 51/302 (16%) Query: 22 YDFVKDIGSGNFG-VARLMRDKLTKELVAVKYI---ERGDKIDENVQREI--INHRSLRH 75 Y +K IGSG V +++ +K K++ A+KY+ E ++ ++ + EI +N Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 87 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 187 I H DLK N L+ DG LK+ DFG + QP +T VGT Y+ PE Sbjct: 147 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGTVNYMPPE 198 Query: 188 VL----------LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + + +DVWS G LY M G PF ++ + + I+ Sbjct: 199 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 255 Query: 238 KYSI--PD----DIRISPECCHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNES 290 + I PD D++ +CC DP RISIPE+ H + ++ P + M + Sbjct: 256 NHEIEFPDIPEKDLQDVLKCC------LKRDPKQRISIPELLAHPYVQIQTHPVNQMAKG 309 Query: 291 NT 292 T Sbjct: 310 TT 311 >4HVI-A nrPDB Length = 314 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 96/213 (45%), Gaps = 17/213 (7%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMR-DKL---TKELVAVKYIER-GDKIDENVQREII 68 P + + ++ +G GNFG L R D L T LVAVK ++ G + QREI Sbjct: 4 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 63 Query: 69 NHRSLRHPNIVRFKEVILTPTH--LAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQL 125 ++L IV+++ V P L ++MEY G L + + + R + Q+ Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 123 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--- 182 G+ Y S + HRDL N L++ +KI DFG +K L + V P Sbjct: 124 CKGMEYLGSRRCVHRDLAARNILVESE--AHVKIADFGLAKLLPL-DKDYYVVREPGQSP 180 Query: 183 --YIAPEVLLRQEYDGKIADVWSCGVTLYVMLV 213 + APE L + + +DVWS GV LY + Sbjct: 181 IFWYAPESLSDNIFS-RQSDVWSFGVVLYELFT 212 >6O6Q-A nrPDB Length = 335 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 126/298 (42%), Gaps = 48/298 (16%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPN 77 + Y+ ++ +G G + L D +E V +K ++ + + ++REI ++L PN Sbjct: 40 QENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKR--KKIKREISILKNLVDGPN 97 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAG------RFSEDEARFFFQQLLSGVSY 131 I+ +V+ P + + G ++E I N F++ + RF+ +LL + Y Sbjct: 98 IIAMLDVVREP-------QSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALDY 150 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 HSM I HRD+K N ++D L++ D+G ++ ++ V + + PE+L+ Sbjct: 151 SHSMGIMHRDVKPHNVMIDHDKKL-LRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVD 209 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIP- 242 D+WS G L M+ PF + D I R+L KY+I Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 243 ----DDI------------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 +DI +S E LI R+ D R++ E H++F Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >5B2L-A nrPDB Length = 324 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/289 (26%), Positives = 122/289 (42%), Gaps = 56/289 (19%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVRFK 82 ++GSG G MR + T ++AVK + R +EN +R +++ +S P IV+ Sbjct: 24 EMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN-KRILMDLDVVLKSHDCPYIVQCF 82 Query: 83 EVILTPTHLAIIMEYASG----------GELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 +T T + I ME G + ERI + +A ++ ++ Sbjct: 83 GTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE-------- 134 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL--- 189 + HRD+K N LLD ++K+CDFG S V + G AY+APE + Sbjct: 135 -KHGVIHRDVKPSNILLD--ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFED------------PEEP------RDYRK 229 + +YD + ADVWS G++L + G +P+++ EEP + Sbjct: 192 DPTKPDYDIR-ADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSG 250 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 Q VK + D R P+ L+ F+ R E+ SWF Sbjct: 251 DFQSF--VKDCLTKDHRKRPKYNKLLEHSFIK----RYETLEVDVASWF 293 >2W96-B nrPDB Length = 306 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 89/208 (42%), Gaps = 19/208 (9%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI-----ERGDKIDENVQREIINHRSL 73 + RY+ V +IG G +G RD + VA+K + E G I + RE+ R L Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPI--STVREVALLRRL 60 Query: 74 R---HPNIVRFKEVILTP-----THLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQQ 124 HPN+VR +V T + ++ E+ Y + + +Q Sbjct: 61 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 120 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 L G+ + H+ I HRDLK EN L+ +K+ DFG ++ V T Y Sbjct: 121 FLRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALDPVVVTLWYR 178 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVML 212 APEVLL+ Y + D+WS G M Sbjct: 179 APEVLLQSTYATPV-DMWSVGCIFAEMF 205 >4CRL-A nrPDB Length = 406 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 120/290 (41%), Gaps = 58/290 (20%) Query: 49 AVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGEL--- 103 A+K IE G I + REI R L+HPN++ ++V L+ + ++ +YA Sbjct: 53 ALKQIE-GTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHII 111 Query: 104 -YERICNAGR----FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPR 156 + R A + + Q+L G+ Y H+ + HRDLK N L+ +G R Sbjct: 112 KFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGR 171 Query: 157 LKICDFGYSKSSVLHSQPKS----TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 +KI D G+++ +P + V T Y APE+LL + K D+W+ G +L Sbjct: 172 VKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELL 231 Query: 213 -----------------------------VGAYP----FED----PEEP---RDYRKTIQ 232 V +P +ED PE +D+R+ Sbjct: 232 TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTY 291 Query: 233 RILS-VKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 S +KY ++ + HL+ ++ DP RI+ + +FL++ Sbjct: 292 TNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLED 341 >3EB0-A nrPDB Length = 383 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 47/238 (19%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 S +Y K +G+G+FG+ + D + + A+K + + + RE+ + L H NI Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK---NRELDIMKVLDHVNI 62 Query: 79 VRF-----------------------------------KEVILTPT---HLAIIMEYA-- 98 ++ K VI+ P+ +L +IMEY Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 99 SGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRL 157 + ++ + +GR + + QL V + HS+ ICHRD+K +N L++ S L Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVN-SKDNTL 181 Query: 158 KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL-RQEYDGKIADVWSCGVTLYVMLVG 214 K+CDFG +K + + + + Y APE++L EY I D+WS G +++G Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSI-DLWSIGCVFGELILG 238 >4YFF-A nrPDB Length = 311 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 99/210 (47%), Gaps = 22/210 (10%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVK------YIERGDKIDENVQREIINHRSLRHP 76 +F + IGSG+FG ++ + + ++VA+K Y + D + RE+ L HP Sbjct: 45 EFHEIIGSGSFG--KVYKGRCRNKIVAIKRYRANTYCSKSDV--DMFCREVSILCQLNHP 100 Query: 77 NIVRFKEVILT-PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ-QLLSGVSYCHS 134 +++F L P+ AI+ +Y SGG L+ + R + +++ + G+ Y H+ Sbjct: 101 CVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160 Query: 135 MQ--ICHRDLKLENTLL--DGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEV 188 + I HRDL N LL DG + DFG S+ S+ G ++APEV Sbjct: 161 LTQPIIHRDLNSHNILLYEDGHAV----VADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 + ADV+S + L+ +L G PF Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >4CSV-A nrPDB Length = 275 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 14/201 (6%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 + +GSG FG + + VAVK ++ G E +E + L+HPN+V+ V Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLKHPNLVQLYGVC 76 Query: 86 LTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + II EY S G L Y R C + Q+ SG++Y S HRDL Sbjct: 77 TKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRDLA 136 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLRQEYDGKI 198 N L+ + +K+ DFG ++ L ++ + T A + APE + + K Sbjct: 137 ARNCLVGENNV--VKVADFGLAR---LINEDEYTARAGAKFPIKWTAPEAISYNRFSIK- 190 Query: 199 ADVWSCGVTLY-VMLVGAYPF 218 +DVW+ G+ L+ + G P+ Sbjct: 191 SDVWAFGILLWEIFTYGQVPY 211 >6EII-A nrPDB Length = 352 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 103/241 (42%), Gaps = 46/241 (19%) Query: 76 PNIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVS 130 PNI+ +++ P A++ E+ + +LY+ + + + RF+ ++L + Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY------DIRFYMYEILKALD 168 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 YCHSM I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 169 YCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 227 Query: 191 -RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSI 241 Q YD + D+WS G L M+ PF + D I ++L KY+I Sbjct: 228 DYQMYDYSL-DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 286 Query: 242 PDDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSW 277 D R +SPE + ++ D +R++ E H + Sbjct: 287 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 346 Query: 278 F 278 F Sbjct: 347 F 347 >5HIE-A nrPDB Length = 302 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 109/240 (45%), Gaps = 20/240 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 IGSG+FG + + K + VAVK + + + + E+ R RH NI+ F Sbjct: 44 IGSGSFGT--VYKGKWHGD-VAVKMLT--PQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 98 Query: 88 PTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLEN 146 P LAI+ ++ G LY + +F + +Q G+ Y H+ I HRDLK N Sbjct: 99 P-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNN 157 Query: 147 TLLDGSPAPRLKICDFGY----SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD--GKIAD 200 L +KI DFG S+ S H Q + G+ ++APEV+ Q+ + +D Sbjct: 158 IFLHEDLT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVIRMQDKNPYSFQSD 214 Query: 201 VWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFV 260 V++ G+ LY ++ G P+ + R I ++ Y PD ++ C + R+ Sbjct: 215 VYAFGIVLYELMTGQLPYSNINN----RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 270 >2ZMD-A nrPDB Length = 390 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 130/302 (43%), Gaps = 51/302 (16%) Query: 22 YDFVKDIGSGNFG-VARLMRDKLTKELVAVKYI---ERGDKIDENVQREI--INHRSLRH 75 Y +K IGSG V +++ +K K++ A+KY+ E ++ ++ + EI +N Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST-------VGTPAYIAPE 187 I H DLK N L+ DG LK+ DFG + QP +T VG Y+ PE Sbjct: 175 GIVHSDLKPANFLIVDG----MLKLIDFGIAN----QMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 188 VL----------LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + + +DVWS G LY M G PF ++ + + I+ Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAIIDP 283 Query: 238 KYSI--PD----DIRISPECCHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNES 290 + I PD D++ +CC DP RISIPE+ H + ++ P + M + Sbjct: 284 NHEIEFPDIPEKDLQDVLKCC------LKRDPKQRISIPELLAHPYVQIQTHPVNQMAKG 337 Query: 291 NT 292 T Sbjct: 338 TT 339 >5HI2-A nrPDB Length = 283 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 110/240 (45%), Gaps = 20/240 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 IGSG+FG + + K + VAVK + + + + E+ R RH NI+ F Sbjct: 28 IGSGSFGT--VYKGKWHGD-VAVKMLT--PQQLQAFKNEVGVLRKTRHVNILLFMGYSTK 82 Query: 88 PTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLEN 146 P LAI+ ++ G LY + + +F + +Q G+ Y H+ I HRDLK N Sbjct: 83 P-QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN 141 Query: 147 TLLDGSPAPRLKICDFGY----SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD--GKIAD 200 L +KI DFG S+ S H Q + G+ ++APEV+ Q+ + +D Sbjct: 142 IFLHEDNT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVIRMQDSNPYSFQSD 198 Query: 201 VWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFV 260 V++ G+ LY ++ G P+ + + R I ++ PD ++ C + R+ Sbjct: 199 VYAFGIVLYELMTGQLPYSNI----NNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMA 254 >3OZ6-A nrPDB Length = 388 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 94/228 (41%), Gaps = 28/228 (12%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSL 73 H +Y+ VK +G G +G+ D+ T E+VAVK I + + Q REI+ L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 74 R-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 H NIV V+ + + + + A ++ QL+ + Y Sbjct: 66 SGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYL 125 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKST---------- 177 HS + HRD+K N LL+ +K+ DFG S+S V ++ P S Sbjct: 126 HSGGLLHRDMKPSNILLNAE--CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 178 -------VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 V T Y APE+LL K D+WS G L +L G F Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIF 231 >4PDO-A nrPDB Length = 299 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 23/209 (11%) Query: 26 KDIGSGNFG---VARLMRDKLTKEL-VAVKYIERG----DKIDENVQREIINHRSLRHPN 77 K IG+G FG L KE+ VA+K ++ G ++D + I+ S H N Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFS--HHN 97 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + VI + II EY G L + + G FS + + + +G+ Y +M Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN 157 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLL 190 HRDL N L++ + K+ DFG S+ VL P++T T + APE + Sbjct: 158 YVHRDLAARNILVNSNLV--CKVSDFGLSR--VLEDDPEATYTTSGGKIPIRWTAPEAIS 213 Query: 191 RQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 +++ +DVWS G+ ++ VM G P+ Sbjct: 214 YRKFTSA-SDVWSFGIVMWEVMTYGERPY 241 >4LFI-A nrPDB Length = 374 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 6/146 (4%) Query: 75 HPNIVRFKEVILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 H NI+ ++I P A++ EY + RI + ++ E RF+ +LL + YC Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYP-KLTDLEIRFYMFELLKALDYC 188 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HSM I HRD+K N ++D +L++ D+G ++ ++ + V + + PE+L+ Sbjct: 189 HSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 247 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPF 218 D+WS G L M+ PF Sbjct: 248 RMYDYSLDLWSFGTMLASMIFKREPF 273 >2R2P-A nrPDB Length = 295 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 99/206 (48%), Gaps = 22/206 (10%) Query: 28 IGSGNFGVARLMRDKL--TKEL-VAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 IG+G FG R KL +EL VA+K ++ G E +R+ + S+ HPNI+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG--YTEKQRRDFLGEASIMGQFDHPNIIH 87 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ + I+ EY G L + N G+F+ + + + +G+ Y M H Sbjct: 88 LEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVH 147 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLLRQE 193 RDL N L++ + K+ DFG S+ VL P++ T + APE + ++ Sbjct: 148 RDLAARNILINSNLV--CKVSDFGLSR--VLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 203 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPF 218 + +DVWS G+ ++ V+ G P+ Sbjct: 204 FTSA-SDVWSYGIVMWEVVSYGERPY 228 >5IKW-A nrPDB Length = 310 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 126/304 (41%), Gaps = 48/304 (15%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV-QREIINHRSLR-HPNIVRFKE 83 + + G F L+R A+K + + D NV +REI + L H NIV + + Sbjct: 20 ESLAEGGFSTVFLVRTHGGIR-CALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLD 78 Query: 84 VILTPT-----HLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQ 136 + + I+MEY G++ ++ + F+E E F V+ H + Sbjct: 79 CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCK 138 Query: 137 --ICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTPAYI 184 I HRDLK+EN LL DG +CDFG + + L+ Q T +Y Sbjct: 139 TPIIHRDLKVENILLNDGG---NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYR 195 Query: 185 APEVLLRQEYDGK----IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 APE++ Y GK AD+W+ G LY + PF + + I ++ Sbjct: 196 APEMI--NLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA---------ICDGNFT 244 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF-----LKNLPADLMNESNTGSQ 295 IPD+ R S LI + DP R P+I S+F + P +N S+ S Sbjct: 245 IPDNSRYSRNIHCLIRFMLEPDPEHR---PDIFQVSYFAFKFAAADCPVSNINNSSIPSA 301 Query: 296 FQEP 299 EP Sbjct: 302 LPEP 305 >4MD7-E nrPDB Length = 391 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 103/241 (42%), Gaps = 46/241 (19%) Query: 76 PNIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVS 130 PNI+ +++ P A++ E+ + +LY+ + + + RF+ ++L + Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDY------DIRFYMYEILKALD 145 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 YCHSM I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 146 YCHSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 Query: 191 -RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSI 241 Q YD + D+WS G L M+ PF + D I ++L KY+I Sbjct: 205 DYQMYDYSL-DMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI 263 Query: 242 PDDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSW 277 D R +SPE + ++ D +R++ E H + Sbjct: 264 ELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 Query: 278 F 278 F Sbjct: 324 F 324 >5L6P-A nrPDB Length = 298 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 99/211 (46%), Gaps = 26/211 (12%) Query: 28 IGSGNFG---VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 IG+G FG RL + + VA+K ++ G E +R+ ++ S+ HPNI+R Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG--YTERQRRDFLSEASIMGQFDHPNIIR 84 Query: 81 FKEVILTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + V+ + I+ E+ L + R+ N G+F+ + + + +G+ Y M Sbjct: 85 LEGVVTKSRPVMILTEFMENCALDSFLRL-NDGQFTVIQLVGMLRGIAAGMKYLSEMNYV 143 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--------YIAPEVLL 190 HRDL N L++ + K+ DFG S+ L P T + + APE + Sbjct: 144 HRDLAARNILVNSNLV--CKVSDFGLSR--FLEDDPSDPTYTSSLGGKIPIRWTAPEAIA 199 Query: 191 RQEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 +++ +DVWS G+ ++ VM G P+ D Sbjct: 200 YRKFTSA-SDVWSYGIVMWEVMSYGERPYWD 229 >4LQP-A nrPDB Length = 508 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/108 (43%), Positives = 60/108 (55%), Gaps = 10/108 (9%) Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF--EDPEEPRDYRKTIQR 233 STVGTP YIAPE+ L Q Y G+ D WS G +Y L+G PF E P+E YRK + Sbjct: 322 STVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQET--YRKIMNF 378 Query: 234 ILSVKYSIPDDIRISPECCHLISRIFV-ADP--ATRISIPEIKTHSWF 278 ++++ PDDI IS E LI R+ AD EIK+H +F Sbjct: 379 EQTLQF--PDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFF 424 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 69/145 (47%), Gaps = 6/145 (4%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 VK IG G FG RL++ K T ++ A+K + + + ++ + R + P +V Sbjct: 107 VKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVS 166 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 +L +IME+ GG+L + F+ED RF+ + + + H + HR Sbjct: 167 LYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHR 226 Query: 141 DLKLENTLLDGSPAPRLKICDFGYS 165 +K +N L+D +K+ DFG S Sbjct: 227 AIKPDNILID--IRGHIKLSDFGLS 249 >5X8I-B nrPDB Length = 346 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 89/325 (27%), Positives = 126/325 (38%), Gaps = 70/325 (21%) Query: 19 SDRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREI--INHRSLRH 75 S RY+ V +G G FG V + K VAVK ++ D+ E + EI + H + Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTD 71 Query: 76 PN----IVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGV 129 PN V+ E H+ I+ E G Y+ I G F D R Q+ V Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 130 SYCHSMQICHRDLKLENTLL---DGSPA--------------PRLKICDFGYSKSSVLHS 172 ++ HS ++ H DLK EN L D + A P +K+ DFG S+ Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SATYDD 187 Query: 173 QPKST-VGTPAYIAPEVLLRQEYDGKIADVWSCGVTL--YVMLVGAYPFEDPEEPRDY-- 227 + ST V T Y APEV+L + + DVWS G L Y + +P D +E Sbjct: 188 EHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMME 246 Query: 228 -------RKTIQRILSVKYSIPDDI---------RISPECCH------------------ 253 + IQ+ KY D + R C Sbjct: 247 RILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFD 306 Query: 254 LISRIFVADPATRISIPEIKTHSWF 278 LI ++ DPA RI++ E H +F Sbjct: 307 LIQKMLEYDPAKRITLREALKHPFF 331 >5VC6-A nrPDB Length = 289 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 113/280 (40%), Gaps = 36/280 (12%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSL-RHPNIVR 80 ++ IGSG FG +L + A+K ++ G ++N RE+ H L +H ++VR Sbjct: 16 LEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR 75 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGR----FSEDEARFFFQQLLSGVSYCHSMQ 136 + H+ I EY +GG L + I R F E E + Q+ G+ Y HSM Sbjct: 76 YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMS 135 Query: 137 ICHRDLKLENTLLDGSPAPR-----------------LKICDFGYSKSSVLHSQPKSTVG 179 + H D+K N + + P KI D G+ S P+ G Sbjct: 136 LVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRI---SSPQVEEG 192 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 ++A EVL AD+++ +T+ V GA P P + + Q L Sbjct: 193 DSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPL--PRNGDQWHEIRQGRLP--- 246 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 IP +S E L+ + DP R S + HS L Sbjct: 247 RIPQ--VLSQEFTELLKVMIHPDPERRPSAMALVKHSVLL 284 >4OW8-A nrPDB Length = 283 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 89/211 (42%), Gaps = 14/211 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 S RY + I +G G D VAVK ++ D E + E L Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 69 Query: 75 HPNIVR---FKEVILTPTHLA--IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP I + E + ++ME +G L + GR S A +Q + Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 129 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 187 H+ + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 130 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 L + +DV+S GV Y + G PF Sbjct: 188 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 217 >1JPA-A nrPDB Length = 312 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 96/210 (45%), Gaps = 24/210 (11%) Query: 28 IGSGNFGVARLMRDKLTKE---LVAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 IG+G FG KL + VA+K ++ G E +R+ ++ S+ HPN++ Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG--YTEKQRRDFLSEASIMGQFDHPNVIH 98 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ T + II E+ G L + N G+F+ + + + +G+ Y M H Sbjct: 99 LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVH 158 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA--------YIAPEVLLR 191 RDL N L++ + K+ DFG S+ L T A + APE + Sbjct: 159 RDLAARNILVNSNLV--CKVSDFGLSR--FLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 192 QEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 +++ +DVWS G+ ++ VM G P+ D Sbjct: 215 RKFTSA-SDVWSYGIVMWEVMSYGERPYWD 243 >6B2Q-A nrPDB Length = 317 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 89/211 (42%), Gaps = 14/211 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 S RY + I +G G D VAVK ++ D E + E L Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 90 Query: 75 HPNIVR---FKEVILTPTHLA--IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP I + E + ++ME +G L + GR S A +Q + Sbjct: 91 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 150 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 187 H+ + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 151 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 L + +DV+S GV Y + G PF Sbjct: 209 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 238 >4X3F-A nrPDB Length = 337 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 89/211 (42%), Gaps = 14/211 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 S RY + I +G G D VAVK ++ D E + E L Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 70 Query: 75 HPNIVR---FKEVILTPTHLA--IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP I + E + ++ME +G L + GR S A +Q + Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 130 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS--SVLHSQPKSTVGTPAYIAPE 187 H+ + HRD+K N L+ +P ++KI DFG +K+ + +Q +GT YIAPE Sbjct: 131 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 L + +DV+S GV Y + G PF Sbjct: 189 QALGHDAS-PASDVYSLGVVGYEAVSGKRPF 218 >5UIU-A nrPDB Length = 323 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 96/209 (45%), Gaps = 17/209 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIE-----RGDKIDENVQREIINHRSLRHPNIVRFK 82 +G G FGV + + + VAVK + +++ + +EI +H N+V Sbjct: 55 MGEGGFGV--VYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 83 EVILTPTHLAIIMEYASGGELYERI-CNAGR--FSEDEARFFFQQLLSGVSYCHSMQICH 139 L ++ Y G L +R+ C G S Q +G+++ H H Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 172 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAYIAPEVLLRQEYDG 196 RD+K N LLD A KI DFG +++S +Q T VGT AY+APE LR E Sbjct: 173 RDIKSANILLD--EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA-LRGEITP 229 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPR 225 K +D++S GV L ++ G ++ EP+ Sbjct: 230 K-SDIYSFGVVLLEIITGLPAVDEHREPQ 257 >1U59-A nrPDB Length = 287 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 99/210 (47%), Gaps = 18/210 (8%) Query: 27 DIGSGNFGVARLMRDKLTKEL--VAVKYIERG-DKID-ENVQREIINHRSLRHPNIVRFK 82 ++G GNFG R ++ K+ VA+K +++G +K D E + RE L +P IVR Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVSYCHSMQICH 139 V L ++ME A GG L++ + G+ E Q+ G+ Y H Sbjct: 77 GVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLRQEYD 195 RDL N LL KI DFG SK+ + +S P + APE + +++ Sbjct: 134 RDLAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 191 Query: 196 GKIADVWSCGVTLYVML-VGAYPFEDPEEP 224 + +DVWS GVT++ L G P++ + P Sbjct: 192 SR-SDVWSYGVTMWEALSYGQKPYKKMKGP 220 >5TE0-A nrPDB Length = 347 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 122/299 (40%), Gaps = 41/299 (13%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVIL 86 + G F + L+R + + + + +REI R L H NIV + + + Sbjct: 27 LAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSI 86 Query: 87 TPT------HLAIIMEYASGGE---LYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ- 136 + I+M++ GG+ L + G F+E+E F V+ H + Sbjct: 87 NNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVARLHQCKT 145 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG---------TPAYIAP 186 I HRDLK+EN LL +CDFG + + + Q + T +Y AP Sbjct: 146 PIIHRDLKVENILLHDRG--HYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 203 Query: 187 EVLLRQEYDGKI----ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 E++ Y GKI AD+W+ G LY + PF + + I ++IP Sbjct: 204 EMV--NLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA---------ICDGNFTIP 252 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL--KNLPADLMNESNTGSQFQEP 299 D+ R S + LI + DP R I ++ S+ L K P + S ++ EP Sbjct: 253 DNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEP 311 >2XYN-A nrPDB Length = 292 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 103/259 (39%), Gaps = 21/259 (8%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G +G + K VAVK ++ E +E + ++HPN+V+ V Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTL 99 Query: 88 PTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 I+ EY G L Y R CN + + Q+ S + Y HRDL Sbjct: 100 EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 159 Query: 146 NTLLDGSPAPRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 N L+ + +K+ DFG S+ + H+ K + + APE L + K +D Sbjct: 160 NCLVGENHV--VKVADFGLSRLMTGDTYTAHAGAKFPI---KWTAPESLAYNTFSIK-SD 213 Query: 201 VWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIF 259 VW+ GV L+ + G P+ P + +L Y + P+ L+ + Sbjct: 214 VWAFGVLLWEIATYGMSPY-----PGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACW 268 Query: 260 VADPATRISIPEIKTHSWF 278 PA R S E TH F Sbjct: 269 KWSPADRPSFAE--THQAF 285 >3KUL-B nrPDB Length = 325 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 100/216 (46%), Gaps = 22/216 (10%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERGDKIDENVQREIINHRSLR 74 ++ R K IGSG+ G R ++ + VA+K ++ G E +R+ ++ S+ Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG--YTERQRRDFLSEASIM 104 Query: 75 ----HPNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGV 129 HPNI+R + V+ I+ EY G L + + G+F+ + + + +G+ Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 164 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------Y 183 Y + HRDL N L+D + K+ DFG S+ VL P + T + Sbjct: 165 RYLSDLGYVHRDLAARNVLVDSNLV--CKVSDFGLSR--VLEDDPDAAYTTTGGKIPIRW 220 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 APE + + + +DVWS GV ++ V+ G P+ Sbjct: 221 TAPEAIAFRTFS-SASDVWSFGVVMWEVLAYGERPY 255 >5H2U-A nrPDB Length = 267 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 68/263 (25%), Positives = 109/263 (41%), Gaps = 22/263 (8%) Query: 20 DRYDFVKDIGSGNFG--VARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSLRHP 76 + + + +GSG FG L +D++ VA+K I R + + + +Q EI + LRH Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQ---VAIKVISRDNLLHQQMLQSEIQAMKKLRHK 62 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYE--RICNAGRFSEDEARFFFQQLLSGVSYCHS 134 +I+ V+ + II E + G L E R + E Q+ G+ Y S Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYIAPEVLLR 191 HRDL N L+ + K+ DFG + K V S + + APE L R Sbjct: 123 QNYIHRDLAARNILVGENTL--CKVGDFGLARLIKEDVYLSHDHNI--PYKWTAPEALSR 178 Query: 192 QEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Y K +DVWS G+ L+ M G P+ + + + Y +P + P Sbjct: 179 GHYSTK-SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR-----VDAGYRMPCPLECPPS 232 Query: 251 CCHLISRIFVADPATRISIPEIK 273 L+ + DP R + ++ Sbjct: 233 VHKLMLTCWCRDPEQRPTFKALR 255 >3DKO-A nrPDB Length = 318 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 99/208 (47%), Gaps = 22/208 (10%) Query: 28 IGSGNFGVARLMRDKLTKE---LVAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 IG+G FG R KL + VA+K ++ G E +R+ + S+ HPN+V Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG--YTEKQRRDFLCEASIMGQFDHPNVVH 108 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ + I++E+ G L + + G+F+ + + + +G+ Y M H Sbjct: 109 LEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVH 168 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA------YIAPEVLLRQE 193 RDL N L++ + K+ DFG S+ V+ P++ T + APE + ++ Sbjct: 169 RDLAARNILVNSNLV--CKVSDFGLSR--VIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 224 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPFED 220 + +DVWS G+ ++ VM G P+ D Sbjct: 225 FTSA-SDVWSYGIVMWEVMSYGERPYWD 251 >2A1A-B nrPDB Length = 284 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 91/203 (44%), Gaps = 24/203 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF------ 81 IGSG FG + ++ + +K ++ + E +RE+ L H NIV + Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIKRVKYNN---EKAEREVKALAKLDHVNIVHYNGCWDG 75 Query: 82 ---------KEVILTPTH-LAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGV 129 K + T L I ME+ G L + I + + A F+Q+ GV Sbjct: 76 FDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV 135 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y HS ++ +RDLK N L ++KI DFG S + + GT Y++PE + Sbjct: 136 DYIHSKKLINRDLKPSNIFL--VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI 193 Query: 190 LRQEYDGKIADVWSCGVTLYVML 212 Q+Y GK D+++ G+ L +L Sbjct: 194 SSQDY-GKEVDLYALGLILAELL 215 >1BYG-A nrPDB Length = 278 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 109/263 (41%), Gaps = 24/263 (9%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 ++ IG G FG L + K VAVK I + D + E LRH N+V+ Sbjct: 25 LLQTIGKGEFGDVMLGDYRGNK--VAVKCI-KNDATAQAFLAEASVMTQLRHSNLVQLLG 81 Query: 84 VILT-PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQICHR 140 VI+ L I+ EY + G L + + + GR D F + + Y HR Sbjct: 82 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 141 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-YIAPEVLLRQEYDGKIA 199 DL N L+ S K+ DFG +K + S + T P + APE L +++ K + Sbjct: 142 DLAARNVLV--SEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALREKKFSTK-S 195 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI-------PDDIRISPECC 252 DVWS G+ L+ + Y F PR K + + Y + P + C Sbjct: 196 DVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCW 251 Query: 253 HLISRIFVADPATRISIPEIKTH 275 HL + + + R + IKTH Sbjct: 252 HLDAAMRPSFLQLREQLEHIKTH 274 >5XVU-A nrPDB Length = 332 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 102/241 (42%), Gaps = 46/241 (19%) Query: 76 PNIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVS 130 PNI++ +++ P ++I EY + LY + F++ + R++ Q+L + Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPK------FTDKDIRYYIYQILKALD 139 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 YCHS I HRD+K N ++D ++++ +G ++ + V + Y PE+L+ Sbjct: 140 YCHSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLI 198 Query: 191 -RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK----YSIPDDI 245 Q YD + D+WS G L M+ PF + D I ++L + Y +I Sbjct: 199 DLQLYDYSL-DIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNI 257 Query: 246 RISP----------------------------ECCHLISRIFVADPATRISIPEIKTHSW 277 ++ P E LI ++ + D A RI+ E H + Sbjct: 258 KLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPY 317 Query: 278 F 278 F Sbjct: 318 F 318 >4HZS-A nrPDB Length = 341 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 98/212 (46%), Gaps = 25/212 (11%) Query: 24 FVKDIGSGNFGVARLMR-DKLTKELVAVKY-------IERGDKIDENVQREIINHRSLRH 75 ++ +G G+FGV R D + + V+V + + + +D+ + RE+ SL H Sbjct: 16 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI-REVNAMHSLDH 74 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHS 134 N++R V+LTP + ++ E A G L +R+ + G F + Q+ G+ Y S Sbjct: 75 RNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLES 133 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-------SVLHSQPKSTVGTPAYIAPE 187 + HRDL N LL + +KI DFG ++ V+ K A+ APE Sbjct: 134 KRFIHRDLAARNLLL--ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF---AWCAPE 188 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLV-GAYPF 218 L + + +D W GVTL+ M G P+ Sbjct: 189 SLKTRTFS-HASDTWMFGVTLWEMFTYGQEPW 219 >2JD5-A nrPDB Length = 373 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 108/244 (44%), Gaps = 53/244 (21%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI------DE------------- 61 RY V+ +G G+F L +D + VA+K I RGDK+ DE Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMK-IVRGDKVYTEAAEDEIKLLQRVNDADNT 78 Query: 62 -------NVQREIINHRSLRHPNIVRFKEV--ILTPTHLAIIMEYASGG--ELYERICNA 110 N ++++H + + PN V V +L LA+I +Y G +Y + + Sbjct: 79 KEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQIS- 137 Query: 111 GRFSEDEARFFFQQLLSGVSYCHSM-QICHRDLKLENTLLDGSPAP----RLKICDFGYS 165 +QLL G+ Y H I H D+K EN L++ +P ++KI D G Sbjct: 138 ------------KQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG-- 183 Query: 166 KSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPR 225 + +++ T Y +PEVLL + G AD+WS ++ ++ G + FE P+E Sbjct: 184 NACWYDEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFE-PDEGH 241 Query: 226 DYRK 229 Y K Sbjct: 242 SYTK 245 >1U54-B nrPDB Length = 291 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 98/212 (46%), Gaps = 25/212 (11%) Query: 24 FVKDIGSGNFGVARLMR-DKLTKELVAVKY-------IERGDKIDENVQREIINHRSLRH 75 ++ +G G+FGV R D + + V+V + + + +D+ + RE+ SL H Sbjct: 22 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFI-REVNAMHSLDH 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHS 134 N++R V+LTP + ++ E A G L +R+ + G F + Q+ G+ Y S Sbjct: 81 RNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLES 139 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-------SVLHSQPKSTVGTPAYIAPE 187 + HRDL N LL + +KI DFG ++ V+ K A+ APE Sbjct: 140 KRFIHRDLAARNLLL--ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF---AWCAPE 194 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLV-GAYPF 218 L + + +D W GVTL+ M G P+ Sbjct: 195 SLKTRTFS-HASDTWMFGVTLWEMFTYGQEPW 225 >3PLS-A nrPDB Length = 298 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/257 (27%), Positives = 114/257 (44%), Gaps = 31/257 (12%) Query: 28 IGSGNFGV---ARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFK 82 IG G+FGV + + A+K + R ++ E RE + R L HPN++ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 88 Query: 83 EVILTPTHLA-IIMEYASGGELYERICNAGRF-SEDEARFFFQQLLSGVSYCHSMQICHR 140 ++L P L +++ Y G+L + I + R + + F Q+ G+ Y + HR Sbjct: 89 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHR 148 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTPAYIAPEVLLRQ 192 DL N +LD S +K+ DFG ++ S H + V + A E L Sbjct: 149 DLAARNCMLDESFT--VKVADFGLARDILDREYYSVQQHRHARLPV---KWTALESLQTY 203 Query: 193 EYDGKIADVWSCGVTLYVMLV-GAYPFE--DPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + K +DVWS GV L+ +L GA P+ DP + + +R+ +Y PD + Sbjct: 204 RFTTK-SDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYC-PDSLYQVM 261 Query: 250 ECCHLISRIFVADPATR 266 + C + ADPA R Sbjct: 262 QQC------WEADPAVR 272 >2OZO-A nrPDB Length = 613 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 99/210 (47%), Gaps = 18/210 (8%) Query: 27 DIGSGNFGVARLMRDKLTKEL--VAVKYIERG-DKID-ENVQREIINHRSLRHPNIVRFK 82 ++G GNFG R ++ K+ VA+K +++G +K D E + RE L +P IVR Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVSYCHSMQICH 139 V L ++ME A GG L++ + G+ E Q+ G+ Y H Sbjct: 403 GVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLRQEYD 195 R+L N LL KI DFG SK+ + +S P + APE + +++ Sbjct: 460 RNLAARNVLLVNRHY--AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 Query: 196 GKIADVWSCGVTLYVML-VGAYPFEDPEEP 224 + +DVWS GVT++ L G P++ + P Sbjct: 518 SR-SDVWSYGVTMWEALSYGQKPYKKMKGP 546 >4E93-A nrPDB Length = 377 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 87/208 (41%), Gaps = 22/208 (10%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ--REIINHRSLRHPNIVRFKE 83 + IG GNFG R + LVAVK D + +E + HPNIVR Sbjct: 120 EQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 179 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLL-------SGVSYCHSMQ 136 V + I+ME GG+ + G AR + LL +G+ Y S Sbjct: 180 VCTQKQPIYIVMELVQGGDFLTFLRTEG------ARLRVKTLLQMVGDAAAGMEYLESKC 233 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPA-YIAPEVLLRQE 193 HRDL N L+ LKI DFG S+ +++ P + APE L Sbjct: 234 CIHRDLAARNCLVTEKNV--LKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 291 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPFED 220 Y + +DVWS G+ L+ +GA P+ + Sbjct: 292 YSSE-SDVWSFGILLWETFSLGASPYPN 318 >6HMD-A nrPDB Length = 365 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/240 (23%), Positives = 100/240 (41%), Gaps = 46/240 (19%) Query: 77 NIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLLSGVSY 131 NI++ + + P A++ EY + +LY+ + + + RF+ +LL + Y Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF------DIRFYMYELLKALDY 162 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL- 190 CHS I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 163 CHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 221 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIP 242 Q YD + D+WS G L M+ PF ++ D I ++L KY I Sbjct: 222 YQMYDYSL-DMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 280 Query: 243 DDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 D +SPE L+ ++ D R++ E H +F Sbjct: 281 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >5MJB-A nrPDB Length = 305 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 98/208 (47%), Gaps = 20/208 (9%) Query: 28 IGSGNFGVARLMRDKL--TKEL-VAVKYIERGDKIDENVQREIINHRSLR----HPNIVR 80 IG+G FG R KL +E+ VA+K ++ G E +R+ ++ S+ H NI+R Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG--YSEKQRRDFLSEASIMGQFDHRNIIR 91 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ + II E+ L + N G+F+ + + + +G+ Y M H Sbjct: 92 LEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVH 151 Query: 140 RDLKLENTLLDGSPAPRLKICDFG---YSKSSVLHSQPKSTVGTPA---YIAPEVLLRQE 193 RDL N L++ + K+ DFG Y + S++G + APE + ++ Sbjct: 152 RDLAARNILVNSNLV--CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 209 Query: 194 YDGKIADVWSCGVTLY-VMLVGAYPFED 220 + +DVWS G+ ++ VM G P+ D Sbjct: 210 FTSA-SDVWSYGIVMWEVMSFGERPYWD 236 >5WNL-A nrPDB Length = 342 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 121/275 (44%), Gaps = 25/275 (9%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 D+ + + +GSG FG +R K +A+K +D+ + E++ + Sbjct: 18 DAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRERMELLE--EAKKME 74 Query: 78 IVRFKEVI----LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 + +F+ ++ + + ++MEY G L E++ + D + G+++ H Sbjct: 75 MAKFRYILPVYGICQEPVGLVMEYMETGSL-EKLLASEPLPWDLRFRIVHETAVGMNFLH 133 Query: 134 SMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-HSQPKST---VGTPAYIAPE 187 M + H +LK N LLD +KI DFG +K + + HS S GT AY+ PE Sbjct: 134 CMSPPLLHLNLKPANILLDAH--YHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 188 VLLRQE--YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 + + +D K DV+S + ++ +L PF D E ++ + + +P Sbjct: 192 RIREKSRLFDTK-HDVYSFAIVIWGVLTQKKPFAD--EKNILHIMMKVVKGHRPELPPIC 248 Query: 246 RISPECCH----LISRIFVADPATRISIPEIKTHS 276 R P C L+ R + ADP R + EI + + Sbjct: 249 RPRPRACASLIGLMQRCWHADPQVRPTFQEITSET 283 >2PVN-A nrPDB Length = 352 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 103/244 (42%), Gaps = 52/244 (21%) Query: 76 PNIVRFKEVIL-----TPTHLAIIMEYASGGE---LYERICNAGRFSEDEARFFFQQLLS 127 PNIV+ +++ TP+ +I EY + + LY + ++ + R++ +LL Sbjct: 107 PNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVLYPTL------TDYDIRYYIYELLK 157 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 + YCHS I HRD+K N ++D +L++ D+G ++ + V + + PE Sbjct: 158 ALDYCHSQGIMHRDVKPHNVMID-HELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPE 216 Query: 188 VLL-RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------K 238 +L+ Q+YD + D+WS G M+ PF + D I ++L K Sbjct: 217 LLVDLQDYDYSL-DMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNK 275 Query: 239 YSIPDDIR------------------------ISPECCHLISRIFVADPATRISIPEIKT 274 Y I D + +SPE + ++ D R++ E T Sbjct: 276 YRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMT 335 Query: 275 HSWF 278 H +F Sbjct: 336 HPYF 339 >4NEU-A nrPDB Length = 333 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 38/278 (13%) Query: 23 DFVK--DIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQREIINHRSLRHPN 77 DF++ ++ SG FG L + T+ L+ +K + +G +E + E LRH Sbjct: 25 DFLESAELDSGGFGKVSLCFHR-TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V+ VI+ +++MEY G L + +++ G+ Y H + Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 143 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFG---YSKSSVLHSQ-----------PKSTVGTPAY 183 H+DLK EN L+D +KI D G + S L+++ K GT Y Sbjct: 144 IHKDLKPENILVDND--FHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYY 201 Query: 184 IAPEVLLRQEYDGK---IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 +APE L + + K +DV+S V L+ + P+E+ + Q I+ +K Sbjct: 202 MAPEHL--NDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQ------QLIMCIKSG 253 Query: 241 IPDDIRISPECC-----HLISRIFVADPATRISIPEIK 273 D+ E C L+ + A+P R + P I+ Sbjct: 254 NRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIE 291 >3UIU-A nrPDB Length = 306 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 91/216 (42%), Gaps = 37/216 (17%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF------ 81 IGSG FG + ++ + ++ ++ + E +RE+ L H NIV + Sbjct: 20 IGSGGFGQVFKAKHRIDGKTYVIRRVKYNN---EKAEREVKALAKLDHVNIVHYNGCWDG 76 Query: 82 ----------------------KEVILTPTH-LAIIMEYASGGELYERICN--AGRFSED 116 K + T L I ME+ G L + I + + Sbjct: 77 FDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV 136 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 A F+Q+ GV Y HS ++ HRDLK N L ++KI DFG S + Sbjct: 137 LALELFEQITKGVDYIHSKKLIHRDLKPSNIFL--VDTKQVKIGDFGLVTSLKNDGKRTR 194 Query: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 + GT Y++PE + Q+Y GK D+++ G+ L +L Sbjct: 195 SKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELL 229 >1K9A-A nrPDB Length = 450 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 107/254 (42%), Gaps = 17/254 (6%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 ++ IG G FG L + K VAVK I + D + E LRH N+V+ Sbjct: 197 LLQTIGKGEFGDVMLGDYRGNK--VAVKCI-KNDATAQAFLAEASVMTQLRHSNLVQLLG 253 Query: 84 VILT-PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQICHR 140 VI+ L I+ EY + G L + + + GR D F + + Y HR Sbjct: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-YIAPEVLLRQEYDGKIA 199 DL N L+ S K+ DFG +K + S + T P + APE L +++ K + Sbjct: 314 DLAARNVLV--SEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALREKKFSTK-S 367 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIF 259 DVWS G+ L+ + Y F PR K + + Y + P ++ + Sbjct: 368 DVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 Query: 260 VADPATRISIPEIK 273 D ATR + +++ Sbjct: 424 HLDAATRPTFLQLR 437 >4AT3-A nrPDB Length = 299 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 110/238 (46%), Gaps = 35/238 (14%) Query: 9 GPLDMPIMHDSDRYDFV--KDIGSGNFGVARLM--------RDKLTKELVAVKYIE-RGD 57 G +D + H R++ V +++G G FG L +DK+ LVAVK ++ D Sbjct: 1 GAMDTFVQH-IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI---LVAVKTLKDASD 56 Query: 58 KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG------ 111 ++ RE +L+H +IV+F V + L ++ EY G+L + + G Sbjct: 57 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 116 Query: 112 -------RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGY 164 ++ + QQ+ +G+ Y S HRDL N L+ + +KI DFG Sbjct: 117 AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL--VKIGDFGM 174 Query: 165 SK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 S+ S+ + T+ ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 175 SRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE-SDVWSLGVVLWEIFTYGKQPW 231 >6NPU-A nrPDB Length = 298 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/259 (25%), Positives = 105/259 (40%), Gaps = 31/259 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G +G K VAVK ++ E +E + ++HPN+V+ V Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTR 93 Query: 88 PTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 II E+ + G L Y R CN + + Q+ S + Y HRDL Sbjct: 94 EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 153 Query: 146 NTLLDGSPAPRLKICDFGYSK-----SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 N L+ + +K+ DFG S+ + H+ K + + APE L ++ K +D Sbjct: 154 NCLVGENHL--VKVADFGLSRLMTGDTYTAHAGAKFPI---KWTAPESLAYNKFSIK-SD 207 Query: 201 VWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS-PECC-----H 253 VW+ GV L+ + G P+ + + Y + D R+ PE C Sbjct: 208 VWAFGVLLWEIATYGMSPYPGIDLSQVYE-----------LLEKDYRMERPEGCPEKVYE 256 Query: 254 LISRIFVADPATRISIPEI 272 L+ + +P+ R S EI Sbjct: 257 LMRACWQWNPSDRPSFAEI 275 >4M7I-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 93/227 (40%), Gaps = 36/227 (15%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK--IDENVQREIINHRSLRHPNIV 79 ++ ++ +G G FGV ++K+ A+K I ++ E V RE+ L HP IV Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 66 Query: 80 RFKEVILTPT------------HLAIIMEYASGGELYERICNAGRFSEDEARF---FFQQ 124 R+ L +L I M+ L + + E E F Q Sbjct: 67 RYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQ 126 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGY--------SKSSVLHSQPK- 175 + V + HS + HRDLK N +K+ DFG + +VL P Sbjct: 127 IAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 176 ----STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 VGT Y++PE + Y K+ D++S G+ L+ +L YPF Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNSYSHKV-DIFSLGLILFELL---YPF 227 >4XEY-B nrPDB Length = 408 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 95/230 (41%), Gaps = 21/230 (9%) Query: 4 APVTTGPLDMPIMHDSDRYDFVK-------DIGSGNFGVARLMRDKLTKELVAVKYIERG 56 AP P + + D+++ + +G G +G K VAVK ++ Sbjct: 102 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED 161 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGEL--YERICNAGRFS 114 E +E + ++HPN+V+ V II E+ + G L Y R CN + Sbjct: 162 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 221 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-----SSV 169 + Q+ S + Y HRDL N L+ + +K+ DFG S+ + Sbjct: 222 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYT 279 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 H+ K + + APE L ++ K +DVW+ GV L+ + G P+ Sbjct: 280 AHAGAKFPI---KWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPY 325 >3A4O-X nrPDB Length = 286 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 102/226 (45%), Gaps = 18/226 (7%) Query: 24 FVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFK 82 VK +G+G FG V + TK VAVK ++ G + E ++L+H +VR Sbjct: 17 LVKRLGAGQFGEVWMGYYNNSTK--VAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 74 Query: 83 EVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 V+ + II EY + G L + + + G+ + F Q+ G++Y HR Sbjct: 75 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 134 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGK 197 DL+ N L+ S + KI DFG ++ + ++ + G + APE + + K Sbjct: 135 DLRAANVLV--SESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 191 Query: 198 IADVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 +DVWS G+ LY ++ G P+ P + LS Y +P Sbjct: 192 -SDVWSFGILLYEIVTYGKIPY-----PGRTNADVMTALSQGYRMP 231 >3LLT-A nrPDB Length = 360 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 101/231 (43%), Gaps = 38/231 (16%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIE------RGDKIDENVQREIINHRSLRHPNI 78 ++ +G G FG L + K+ AVK + R KI+ ++ ++I + + + NI Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKI-QNDDINNNNI 98 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 V++ + H+ +I E G LYE I N F ++ + + ++L ++Y M Sbjct: 99 VKYHGKFMYYDHMCLIFE-PLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMS 157 Query: 137 ICHRDLKLENTLLDG-----------------------SPAPRLKICDFGYSK-SSVLHS 172 + H DLK EN LLD + + +K+ DFG + S H Sbjct: 158 LTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHG 217 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 S + T Y APEV+L +D +D+WS G L + G+ F E Sbjct: 218 ---SIINTRQYRAPEVILNLGWDVS-SDMWSFGCVLAELYTGSLLFRTHEH 264 >5AMN-A nrPDB Length = 299 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 32/235 (13%) Query: 26 KDIGSGNFG-----VARLMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPNI 78 K +G G FG A ++ + VAVK ++ E ++ E + + HP++ Sbjct: 29 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 88 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNA---GRFSEDEARF-------FFQQLLSG 128 ++ L +I+EYA G L + + G DE F Q+ G Sbjct: 89 IKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQG 148 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK------SSVLHSQPKSTVGTPA 182 + Y M++ HRDL N L+ + ++KI DFG S+ S V SQ + V Sbjct: 149 MQYLAEMKLVHRDLAARNILV--AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV---K 203 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGA--YPFEDPEEPRDYRKTIQRI 234 ++A E L Y + +DVWS GV L+ ++ +G YP PE + KT R+ Sbjct: 204 WMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM 257 >3PP0-A nrPDB Length = 338 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 97/206 (47%), Gaps = 15/206 (7%) Query: 25 VKDIGSGNFGVA----RLMRDKLTKELVAVKYIERGD--KIDENVQREIINHRSLRHPNI 78 VK +GSG FG + + K VA+K + K ++ + E + P + Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYV 81 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 R + LT T + ++ + G L + + N GR + + Q+ G+SY +++ Sbjct: 82 SRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRL 140 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA---YIAPEVLLRQEY 194 HRDL N L+ SP +KI DFG ++ + G ++A E +LR+ + Sbjct: 141 VHRDLAARNVLVK-SPN-HVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF 198 Query: 195 DGKIADVWSCGVTLY-VMLVGAYPFE 219 + +DVWS GVT++ +M GA P++ Sbjct: 199 THQ-SDVWSYGVTVWELMTFGAKPYD 223 >2RIO-A nrPDB Length = 434 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 101/238 (42%), Gaps = 40/238 (16%) Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF--------FFQQLL 126 HPN++R+ T L I +E + + + + S++ + +Q+ Sbjct: 68 HPNVIRYYCSETTDRFLYIALELCNLN--LQDLVESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 127 SGVSYCHSMQICHRDLKLENTLLD-----------GSPAPRLKICDFGYSKS-----SVL 170 SGV++ HS++I HRDLK +N L+ G+ R+ I DFG K S Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 171 HSQPKSTVGTPAYIAPEVLLRQEYDG--------KIADVWSCGVTLYVMLV-GAYPFEDP 221 + + GT + APE+L +E + + D++S G Y +L G +PF D Sbjct: 186 RTNLNNPSGTSGWRAPELL--EESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDK 243 Query: 222 EEPRDYRKTIQRILSV-KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 I+ I S+ + D + E LIS++ DP R + ++ H F Sbjct: 244 YSRES--NIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >2PSQ-A nrPDB Length = 370 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 98/230 (42%), Gaps = 35/230 (15%) Query: 20 DRYDFVKDIGSGNFGVARLM------RDKLTKELVAVKYIERGDKIDENVQREIINHRSL 73 D+ K +G G FG + +DK KE V V D E ++++ + Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDK-PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 139 Query: 74 -----RHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-----------CNAGRFSEDE 117 +H NI+ L +I+EYAS G L E + + R E++ Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 118 ARF-----FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 171 F QL G+ Y S + HRDL N L+ + +KI DFG ++ + + Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV--MKIADFGLARDINNID 257 Query: 172 SQPKSTVGT--PAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 K+T G ++APE L + Y + +DVWS GV ++ + +G P+ Sbjct: 258 YYKKTTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMWEIFTLGGSPY 306 >5WNO-A nrPDB Length = 330 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 63/258 (24%), Positives = 105/258 (40%), Gaps = 32/258 (12%) Query: 26 KDIGSGNFGVARL-----MRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 K +G+G FG R K K VA+K + + + E N LRH N+++ Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 81 FKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + L I+ Y G L + + E + Q+ SG+ Y ++ H Sbjct: 88 IIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVH 147 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP----AYIAPEVLLRQEYD 195 RDL N L+ ++I DFG SK + H T+ + ++A E+ + Y Sbjct: 148 RDLATRNVLV--KKFNHVEITDFGLSK-ILKHDADSITIKSGKVAIKWLAIEIFSKHCYT 204 Query: 196 GKIADVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS--PECC 252 +DVW+ GVT + ++ G P++ S+ + D R+S P C Sbjct: 205 -HASDVWAFGVTCWEIITFGQSPYQGMSTD-----------SIHNFLKDGNRLSQPPNCS 252 Query: 253 ----HLISRIFVADPATR 266 + R ++ADP +R Sbjct: 253 QDLYQELLRCWMADPKSR 270 >4IAN-A nrPDB Length = 358 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 89/208 (42%), Gaps = 14/208 (6%) Query: 21 RYDFVKDIGSGNF-GVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP--- 76 RY+ G G F V R + + VAVK I + + + +E+ + L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 77 ---NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR---FSEDEARFFFQQLLSGVS 130 + +R HL ++ E S L E + G+ R + QQL + Sbjct: 91 DKFHCLRLFRHFYHKQHLCLVFEPLSMN-LREVLKKYGKDVGLHIKAVRSYSQQLFLALK 149 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 I H D+K +N L++ S LK+CDFG S S V + + + Y APE+++ Sbjct: 150 LLKRCNILHADIKPDNILVNESKTI-LKLCDFG-SASHVADNDITPYLVSRFYRAPEIII 207 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPF 218 + YD I D+WS G TLY + G F Sbjct: 208 GKSYDYGI-DMWSVGCTLYELYTGKILF 234 >2FO0-A nrPDB Length = 495 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 95/230 (41%), Gaps = 21/230 (9%) Query: 4 APVTTGPLDMPIMHDSDRYDFVK-------DIGSGNFGVARLMRDKLTKELVAVKYIERG 56 AP P + + D+++ + +G G +G K VAVK ++ Sbjct: 194 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED 253 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGEL--YERICNAGRFS 114 E +E + ++HPN+V+ V II E+ + G L Y R CN + Sbjct: 254 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 313 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-----SSV 169 + Q+ S + Y HR+L N L+ + +K+ DFG S+ + Sbjct: 314 AVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHL--VKVADFGLSRLMTGDTYT 371 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 H+ K + + APE L ++ K +DVW+ GV L+ + G P+ Sbjct: 372 AHAGAKFPI---KWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPY 417 >1AD5-A nrPDB Length = 438 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 109/256 (42%), Gaps = 29/256 (11%) Query: 26 KDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEV 84 K +G+G FG V +K TK VAVK ++ G E E ++L+H +V+ V Sbjct: 188 KKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAV 245 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF--FFQQLLSGVSYCHSMQICHRDL 142 + T + II E+ + G L + + + + + F Q+ G+++ HRDL Sbjct: 246 V-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDL 304 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIA 199 + N L+ S KI DFG ++ VG + APE + + K + Sbjct: 305 RAANILVSASLV--CKIADFGLAR-----------VGAKFPIKWTAPEAINFGSFTIK-S 350 Query: 200 DVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS G+ L ++ G P+ P + R L Y +P E +++ R Sbjct: 351 DVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCPEELYNIMMRC 405 Query: 259 FVADPATRISIPEIKT 274 + P R + I++ Sbjct: 406 WKNRPEERPTFEYIQS 421 >3MDY-A nrPDB Length = 337 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 130/296 (43%), Gaps = 49/296 (16%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 + + VK IG G +G + K E VAVK ++ + EI +RH NI Sbjct: 36 AKQIQMVKQIGKGRYG--EVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENI 93 Query: 79 VRFKEVIL----TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 + F + + T L +I +Y G LY+ + + ++ + + + SG+ + H+ Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSV-SGLCHLHT 152 Query: 135 M--------QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTP 181 I HRDLK +N L+ + I D G + + + P + VGT Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 182 AYIAPEV----LLRQEYDGKI-ADVWSCGVTLYVM--------LVGAY--PFED--PEEP 224 Y+ PEV L R + I AD++S G+ L+ + +V Y P+ D P +P Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 270 Query: 225 --RDYRKTIQRILSVKYSIPDDIRISPECC-----HLISRIFVADPATRISIPEIK 273 D R+ + I ++ S P+ R S + C L++ + +PA+R++ +K Sbjct: 271 SYEDMREIVC-IKKLRPSFPN--RWSSDECLRQMGKLMTECWAHNPASRLTALRVK 323 >3Q4U-A nrPDB Length = 301 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 78/288 (27%), Positives = 121/288 (42%), Gaps = 51/288 (17%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G +G + R E VAVK D+ + E+ N LRH NI+ F +T Sbjct: 16 VGKGRYG--EVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 73 Query: 88 PTH----LAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH--------SM 135 H L +I Y G LY+ + + R + SG+++ H Sbjct: 74 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL-SIASGLAHLHIEIFGTQGKP 132 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--------VGTPAYIAPE 187 I HRDLK +N L+ + + I D G +V+HSQ + VGT Y+APE Sbjct: 133 AIAHRDLKSKNILVKKN--GQCCIADLGL---AVMHSQSTNQLDVGNNPRVGTKRYMAPE 187 Query: 188 VLLRQE----YDG-KIADVWSCGVTLYVM--------LVGAY--PFED--PEEP--RDYR 228 VL +D K D+W+ G+ L+ + +V Y PF D P +P D R Sbjct: 188 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMR 247 Query: 229 KTIQRILSVKYSIPDDIRISP---ECCHLISRIFVADPATRISIPEIK 273 K + + + +IP+ P L+ + +P+ R++ IK Sbjct: 248 KVVC-VDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIK 294 >5HLW-A nrPDB Length = 299 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 94/210 (44%), Gaps = 16/210 (7%) Query: 24 FVKDIGSGNFGV---ARLMRDKLTKELVAVKYIERGDKIDENVQ--REIINHRSLRHPNI 78 F + IG G+FG L+ + K AVK + R I E Q E I + HPN+ Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 79 VRFKEVIL-TPTHLAIIMEYASGGELYERICNAGRF-SEDEARFFFQQLLSGVSYCHSMQ 136 + + L + +++ Y G+L I N + + F Q+ G+ Y S + Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK 143 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGTPA-YIAPEVLLR 191 HRDL N +LD +K+ DFG ++ K+ P ++A E L Sbjct: 144 FVHRDLAARNCMLDEKFT--VKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQT 201 Query: 192 QEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 Q++ K +DVWS GV L+ +M GA P+ D Sbjct: 202 QKFTTK-SDVWSFGVLLWELMTRGAPPYPD 230 >5UNP-A nrPDB Length = 369 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 102/243 (41%), Gaps = 29/243 (11%) Query: 19 SDRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREI-----INHRS 72 +RY+ V +G G FG V + + + VA+K I+ +K E + EI IN + Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKD 92 Query: 73 LRHPNI-VRFKEVILTPTHLAIIMEYASGGEL-YERICNAGRFSEDEARFFFQQLLSGVS 130 + N+ V+ + H+ I E + + N + + R QL V Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVK 152 Query: 131 YCHSMQICHRDLKLENTLLDGS-----------------PAPRLKICDFGYSKSSVLHSQ 173 + H ++ H DLK EN L S + +++ DFG ++ H Sbjct: 153 FLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG--SATFDHEH 210 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 + V T Y APEV+L + + DVWS G ++ VG F+ + R++ ++R Sbjct: 211 HSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQ-THDNREHLAMMER 268 Query: 234 ILS 236 IL Sbjct: 269 ILG 271 >6CTH-A nrPDB Length = 309 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 88/199 (44%), Gaps = 16/199 (8%) Query: 19 SDRYDFVKDIGSGNFG-VAR-LMRDKLTKELVAVKYIERGDK--IDENVQREIINHRSLR 74 + ++ +G G FG V R +RD T +AVK + R K I E I R LR Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDT--YIAVKKVSRASKQGIKEYASEVKIISR-LR 70 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF-FFQQLLSGVSYCH 133 H N+V+ L ++ E+ + G L I E R+ + L S + Y H Sbjct: 71 HKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLH 130 Query: 134 SMQ---ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPEV 188 + HRD+K N +LD S +L DFG ++ K T+ GT Y+APE Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNAKLG--DFGLARLVDHAKGLKKTLLAGTVGYMAPEC 188 Query: 189 LLRQEYDGKIADVWSCGVT 207 L + K +DV+S GV Sbjct: 189 LSSGKAS-KESDVYSFGVV 206 >6HV0-A nrPDB Length = 416 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 98/229 (42%), Gaps = 43/229 (18%) Query: 75 HPNIVRF--KEVILTPTHLAIIMEYASGGELYER--ICNAGRFSEDEARFFFQQLLSGVS 130 HPN++R+ E ++AI + A+ E E+ + G E QQ SG++ Sbjct: 61 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLQQTTSGLA 116 Query: 131 YCHSMQICHRDLKLENTLL---DGSPAPRLKICDFGYSKSSVL----HSQPKSTVGTPAY 183 + HS+ I HRDLK N L+ + + I DFG K + S+ GT + Sbjct: 117 HLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 176 Query: 184 IAPEVLLR--QEYDGKIADVWSCG-VTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 IAPE+L +E D++S G V YV+ G++PF K++QR ++ Sbjct: 177 IAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFG---------KSLQRQANILLG 227 Query: 241 IPDDIRISPECCH-----------LISRIFVADPATRISIPEIKTHSWF 278 S +C H LI ++ DP R S + H +F Sbjct: 228 A-----CSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >6FER-A nrPDB Length = 309 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/182 (29%), Positives = 86/182 (47%), Gaps = 26/182 (14%) Query: 47 LVAVKYIERGDKIDENVQ----REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGE 102 LVAVK + R D ++N + +EI L+ PNI+ V +T L +I EY G+ Sbjct: 52 LVAVKML-RADA-NKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGD 109 Query: 103 LYERIC----------NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGS 152 L + + + S +F Q+ SG+ Y S+ HRDL N L+ + Sbjct: 110 LNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN 169 Query: 153 PAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLRQEYDGKIADVWSCGVT 207 +KI DFG S++ L+S + A +++ E +L ++ +DVW+ GVT Sbjct: 170 YT--IKIADFGMSRN--LYSGDYYRIQGRAVLPIRWMSWESILLGKFT-TASDVWAFGVT 224 Query: 208 LY 209 L+ Sbjct: 225 LW 226 >2HK5-A nrPDB Length = 270 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 112/256 (43%), Gaps = 19/256 (7%) Query: 26 KDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEV 84 K +G+G FG V +K TK VAVK ++ G E E ++L+H +V+ V Sbjct: 21 KKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAV 78 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF--FFQQLLSGVSYCHSMQICHRDL 142 + T + II E+ + G L + + + + + F Q+ G+++ HRDL Sbjct: 79 V-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDL 137 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIA 199 + N L+ S KI DFG ++ + ++ + G + APE + + K + Sbjct: 138 RAANILVSASLV--CKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIK-S 193 Query: 200 DVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 DVWS G+ L ++ G P+ P + R L Y +P E +++ R Sbjct: 194 DVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCPEELYNIMMRC 248 Query: 259 FVADPATRISIPEIKT 274 + P R + I++ Sbjct: 249 WKNRPEERPTFEYIQS 264 >1FVR-A nrPDB Length = 327 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 74/289 (25%), Positives = 114/289 (39%), Gaps = 39/289 (13%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFG---VARLMRDKLTKELVAVK----YIERGDKIDEN 62 P P++ D + F IG GNFG AR+ +D L + A+K Y + D D Sbjct: 16 PTIYPVL-DWNDIKFQDVIGEGNFGQVLKARIKKDGLRMD-AAIKRMKEYASKDDHRDFA 73 Query: 63 VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--------------- 107 + E++ HPNI+ +L + +EYA G L + + Sbjct: 74 GELEVLCKLG-HHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIA 132 Query: 108 -CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 A S + F + G+ Y Q HRDL N L+ + KI DFG S+ Sbjct: 133 NSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA--KIADFGLSR 190 Query: 167 SSVLHSQPKSTVGT--PAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFEDPEE 223 ++ K T+G ++A E L Y +DVWS GV L+ ++ +G P+ Sbjct: 191 GQEVYV--KKTMGRLPVRWMAIESLNYSVYTTN-SDVWSYGVLLWEIVSLGGTPYCGMTC 247 Query: 224 PRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 Y K Q Y + + E L+ + + P R S +I Sbjct: 248 AELYEKLPQ-----GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI 291 >3C1X-A nrPDB Length = 373 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 18/211 (8%) Query: 24 FVKDIGSGNFGV---ARLMRDKLTKELVAVKYIERGDKIDENVQ--REIINHRSLRHPNI 78 F + IG G+FG L+ + K AVK + R I E Q E I + HPN+ Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 79 VRFKEVIL-TPTHLAIIMEYASGGELYERICNAGRF-SEDEARFFFQQLLSGVSYCHSMQ 136 + + L + +++ Y G+L I N + + F Q+ G+ + S + Sbjct: 153 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKK 212 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV------LHSQPKSTVGTPAYIAPEVLL 190 HRDL N +LD +K+ DFG ++ +H++ + + ++A E L Sbjct: 213 FVHRDLAARNCMLDEKFT--VKVADFGLARDMYDKEFDSVHNKTGAKLPV-KWMALESLQ 269 Query: 191 RQEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 Q++ K +DVWS GV L+ +M GA P+ D Sbjct: 270 TQKFTTK-SDVWSFGVLLWELMTRGAPPYPD 299 >1LUF-A nrPDB Length = 343 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 94/221 (42%), Gaps = 37/221 (16%) Query: 23 DFVKDIGSGNFGVARLMRDK--LTKE---LVAVKYI--ERGDKIDENVQREIINHRSLRH 75 ++V+DIG G FG R L E +VAVK + E + + QRE + Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 109 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYE----------------------RICNAG-- 111 PNIV+ V + ++ EY + G+L E R+ + G Sbjct: 110 PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPP 169 Query: 112 RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS--SV 169 S E +Q+ +G++Y + HRDL N L+ + +KI DFG S++ S Sbjct: 170 PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV--VKIADFGLSRNIYSA 227 Query: 170 LHSQPKSTVGTPA-YIAPEVLLRQEYDGKIADVWSCGVTLY 209 + + P ++ PE + Y + +DVW+ GV L+ Sbjct: 228 DYYKADGNDAIPIRWMPPESIFYNRYTTE-SDVWAYGVVLW 267 >5U6B-A nrPDB Length = 307 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 68/289 (23%), Positives = 118/289 (40%), Gaps = 47/289 (16%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-------ENVQREI 67 +M D + K +G G FG +M +L ++ +K + KI E+ E Sbjct: 18 VMVDRHKVALGKTLGEGEFGA--VMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 75 Query: 68 INHRSLRHPNIVRFKEVILTPTHL------AIIMEYASGGEL-----YERICNAGRFSED 116 + + HPN++R V + +I+ + G+L Y R+ + + Sbjct: 76 VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT 135 Query: 117 EARF-FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHS 172 + F + SG+ Y + + HRDL N +L+ + + + + DFG SK + + Sbjct: 136 QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS--VCVADFGLSKKIYNGDYYR 193 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGA---YPFEDPEEPRDYRK 229 Q + +IA E L + Y K +DVWS GVT++ + YP + E DY + Sbjct: 194 QGRIAKMPVKWIAIESLADRVYTSK-SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 252 Query: 230 TIQRILSVKYSIPDDIRISPECC-----HLISRIFVADPATRISIPEIK 273 R+ P C L+SR + +P R S E++ Sbjct: 253 QGNRL------------KQPADCLDGLYALMSRCWELNPQDRPSFTELR 289 >5KMM-A nrPDB Length = 329 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 66/230 (28%), Positives = 102/230 (44%), Gaps = 30/230 (13%) Query: 16 MHDSDRYDFV--KDIGSGNFGVARL-----MRDKLTKELVAVKYI-ERGDKIDENVQREI 67 +H R D V ++G G FG L + + K LVAVK + E + ++ QRE Sbjct: 29 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREA 88 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG------RFSEDEA--R 119 L+H +IVRF V L ++ EY G+L + + G ED A Sbjct: 89 ELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 148 Query: 120 FFFQQLL-------SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSV 169 QLL +G+ Y + HRDL N L+ +KI DFG S+ S+ Sbjct: 149 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLV--VKIGDFGMSRDIYSTD 206 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + T+ ++ PE +L +++ + +DVWS GV L+ + G P+ Sbjct: 207 YYRVGGRTMLPIRWMPPESILYRKFTTE-SDVWSFGVVLWEIFTYGKQPW 255 >5VD3-A nrPDB Length = 311 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/193 (28%), Positives = 85/193 (44%), Gaps = 12/193 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHRSL-RHPN 77 + + +G G++G +R K L AVK RG K E+ +H + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF--FFQQLLSGVSYCHSM 135 VR ++ L + E G ++ C A S EA+ + + L +++ HS Sbjct: 119 CVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + H D+K N L P R K+ DFG + G P Y+APE+L Q Sbjct: 177 GLVHLDVKPANIFL--GPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL--QGSY 232 Query: 196 GKIADVWSCGVTL 208 G ADV+S G+T+ Sbjct: 233 GTAADVFSLGLTI 245 >3BBT-B nrPDB Length = 328 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 96/206 (46%), Gaps = 15/206 (7%) Query: 25 VKDIGSGNFGVA----RLMRDKLTKELVAVKYIER--GDKIDENVQREIINHRSLRHPNI 78 VK +GSG FG + + K VA+K + G K + E + S+ HP++ Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 79 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 VR V L+PT + ++ + G L E + + + Q+ G+ Y ++ Sbjct: 80 VRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRL 138 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEY 194 HRDL N L+ SP +KI DFG ++ + + G ++A E + +++ Sbjct: 139 VHRDLAARNVLVK-SPN-HVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 196 Query: 195 DGKIADVWSCGVTLY-VMLVGAYPFE 219 + +DVWS GVT++ +M G P++ Sbjct: 197 THQ-SDVWSYGVTIWELMTFGGKPYD 221 >5E8V-A nrPDB Length = 316 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 89/213 (41%), Gaps = 34/213 (15%) Query: 28 IGSGNFGVARLMRDKLTK------ELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 +G G F A + + KL + E VAVK + +++I + +L+H NI++F Sbjct: 17 VGKGRF--AEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 74 Query: 82 KEVILTPTHLA----IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS--- 134 T L +I + + G L E + S ++ R L G+++ HS Sbjct: 75 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIAHLHSDHT 133 Query: 135 ------MQICHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTPAY 183 M I HRDLK N L+ L CDFG S SV VGT Y Sbjct: 134 PCGRPKMPIVHRDLKSSNILVKNDLTCCL--CDFGLSLRLDPTLSVDDLANSGQVGTARY 191 Query: 184 IAPEVL-----LRQEYDGKIADVWSCGVTLYVM 211 +APEVL L K DV+S + L+ M Sbjct: 192 MAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >3REP-A nrPDB Length = 271 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/260 (21%), Positives = 106/260 (40%), Gaps = 23/260 (8%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREIINHRSLR 74 D + +F+ + + G L + + + VK ++ D + + E R Sbjct: 8 DFKQLNFLTKLNENHSG--ELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS 65 Query: 75 HPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEARF--FFQQLLSGVS 130 HPN++ +P H +I + G LY + F D+++ F + G++ Sbjct: 66 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 125 Query: 131 YCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 + H+++ I L + ++D R+ + D +S Q + PA++APE Sbjct: 126 FLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS------FQSPGRMYAPAWVAPEA 179 Query: 189 LLRQEYDG--KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 L ++ D + AD+WS V L+ ++ PF D K + ++ +IP Sbjct: 180 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVA--LEGLRPTIPPG-- 235 Query: 247 ISPECCHLISRIFVADPATR 266 ISP L+ DPA R Sbjct: 236 ISPHVSKLMKICMNEDPAKR 255 >4M66-A nrPDB Length = 325 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 91/207 (43%), Gaps = 32/207 (15%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G FGV + VAVK + + + E+ +LR+ N++ +L Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVN-----SKKISWEVKAMVNLRNENVL-----LLL 77 Query: 88 PTHLAIIMEYASGGELYERICN----AGRFSEDEARFF------FQQLLSGVSYCHSMQ- 136 + ++ SG L R AG + R + Q+++ G+ Y HS+ Sbjct: 78 GVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDP 137 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSK-------SSVLHSQPKSTVGTPAYIAPEV 188 + HRDLK N LLD P K+ DFG S S S + + GT AY+ PE+ Sbjct: 138 PLLHRDLKPSNILLD--PELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPEL 195 Query: 189 LLRQEYDG-KIADVWSCGVTLYVMLVG 214 L + K +DV+S G+ ++ +L G Sbjct: 196 LFKVNLKASKASDVYSFGILVWAVLAG 222 >6FEX-A nrPDB Length = 321 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 102/237 (43%), Gaps = 45/237 (18%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKY---IERGDKIDENVQ------------- 64 R F + +G G FG L ++LV++ + + +G + V+ Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARND 76 Query: 65 --REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR--- 119 +E+ L+ PNI+R V + L +I +Y G+L + +A + + A Sbjct: 77 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL-NQFLSAHQLEDKAAEGAP 135 Query: 120 -----------FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS 168 Q+ SG+ Y ++ HRDL N L+ + +KI DFG S++ Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT--IKIADFGMSRN- 192 Query: 169 VLHSQPKSTVGTPA-----YIAPEVLLRQEYDGKIADVWSCGVTLY--VMLVGAYPF 218 L++ V A ++A E +L ++ +DVW+ GVTL+ +ML A PF Sbjct: 193 -LYAGDYYRVQGRAVLPIRWMAWECILMGKFT-TASDVWAFGVTLWEVLMLCRAQPF 247 >5EG3-A nrPDB Length = 334 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 35/230 (15%) Query: 20 DRYDFVKDIGSGNFGVARLM------RDKLTKELVAVKYIERGDKIDENVQREIINHRSL 73 D+ K +G G FG + +DK KE V V D E ++++ + Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDK-PKEAVTVAVKMLKDDATEKDLSDLVSEMEM 93 Query: 74 -----RHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-----------CNAGRFSEDE 117 +H NI+ L +I+ YAS G L E + + R E++ Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 118 ARF-----FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVL 170 F QL G+ Y S + HRDL N L+ + +KI DFG ++ +++ Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV--MKIADFGLARDINNID 211 Query: 171 HSQPKSTVGTPA-YIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + + P ++APE L + Y + +DVWS GV ++ + +G P+ Sbjct: 212 FFKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMWEIFTLGGSPY 260 >2X7G-A nrPDB Length = 389 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 106/291 (36%), Gaps = 68/291 (23%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH----- 75 RY ++ +G G+F L D K VA+K ++ E EI + +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 76 PN-------IVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQLL 126 PN I FK + H+ ++ E G L + I N + +Q+L Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSIIRQVL 150 Query: 127 SGVSYCHS-MQICHRDLKLENTLL-------------------DGSPAP----------- 155 G+ Y HS +I H D+K EN L+ G+P P Sbjct: 151 QGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAA 210 Query: 156 ---------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 R+KI D G + +H + T Y + EVL+ Y AD Sbjct: 211 DLLVNPLDPRNADKIRVKIADLG--NACWVHKHFTEDIQTRQYRSIEVLIGAGYSTP-AD 267 Query: 201 VWSCGVTLYVMLVGAYPFEDPEEPRDYRK---TIQRILSVKYSIPDDIRIS 248 +WS + + G Y FE P DY + I I+ + SIP +S Sbjct: 268 IWSTACMAFELATGDYLFE-PHSGEDYSRDEDHIAHIIELLGSIPRHFALS 317 >5AR8-A nrPDB Length = 326 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 109/265 (41%), Gaps = 22/265 (8%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEV 84 ++ + G G R + VAVK++ + ++ +++++ + H + Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 85 IL----TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ---QLLSGVSYCHSMQ- 136 IL P L I+ EY G L E + + + F+ ++ GV+Y H+M Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVL 189 + H DLK +N LLD +KI DFG SK ++ + GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNE--FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 190 -LRQEYDGKIA-DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI---QRILSVKYSIPDD 244 Q+ I D++S V + +L PFED P ++ R + + S+P D Sbjct: 215 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYD 274 Query: 245 IRISPECCHLISRIFVADPATRISI 269 I LI + +P R S Sbjct: 275 IPHRARMISLIESGWAQNPDERPSF 299 >4PL5-B nrPDB Length = 435 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 97/229 (42%), Gaps = 43/229 (18%) Query: 75 HPNIVRF--KEVILTPTHLAIIMEYASGGELYER--ICNAGRFSEDEARFFFQQLLSGVS 130 HPN++R+ E ++AI + A+ E E+ + G E Q SG++ Sbjct: 80 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGL----EPITLLHQTTSGLA 135 Query: 131 YCHSMQICHRDLKLENTLLDGSPA-PRLK--ICDFGYSKSSVL----HSQPKSTVGTPAY 183 + HS+ I HRDLK N LL A R+K I DFG K + S+ GT + Sbjct: 136 HLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGW 195 Query: 184 IAPEVLLRQEYDGK--IADVWSCG-VTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 IAPE+L D D++S G V YV+ G +PF K++QR ++ Sbjct: 196 IAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFG---------KSLQRQANILLG 246 Query: 241 IPDDIRISPECCH-----------LISRIFVADPATRISIPEIKTHSWF 278 + +C H LI ++ DP R S + H +F Sbjct: 247 A-----CNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4K33-A nrPDB Length = 325 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 102/230 (44%), Gaps = 37/230 (16%) Query: 21 RYDFVKDIGSGNFGVARLM------RDKLTKEL-VAVKYIERGDKIDENVQREIINHRSL 73 R K +G G FG + +D+ K + VAVK + + D D+++ + + Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKML-KDDATDKDLSDLVSEMEMM 95 Query: 74 R----HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-----FSED-----EAR 119 + H NI+ L +++EYA+ G L E A R +S D E + Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLRE-FLRARRPPGLDYSFDTSKPPEEQ 154 Query: 120 FFFQQLLS-------GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 171 F+ L+S G+ Y S + HRDL N L+ +KI DFG ++ L Sbjct: 155 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV--MKIADFGLARDVHNLD 212 Query: 172 SQPKSTVGT--PAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 ++T G ++APE L + Y + +DVWS GV L+ + +G P+ Sbjct: 213 YYKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLLWEIFTLGGSPY 261 >3RAW-A nrPDB Length = 381 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 79/331 (23%), Positives = 122/331 (36%), Gaps = 70/331 (21%) Query: 20 DRYDFVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 +RY+ V ++G G FG V + K VA+K I K E + EI + ++ + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 79 V-RFKEVILT-----PTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQLLSGVS 130 +F V+++ H+ I E G +E + N + R QL + Sbjct: 111 ENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRL-----------------KICDFGYSKSSVLHSQ 173 + H Q+ H DLK EN L S L ++ DFG ++ H Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG--SATFDHEH 227 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 + V T Y PEV+L + + DVWS G L+ G F+ E R++ +++ Sbjct: 228 HTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQ-THENREHLVMMEK 285 Query: 234 ILS------------VKYSIP---------DDIRISPECCH------------------L 254 IL KY D R E C L Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNLPAD 285 + R+ DPA RI++ E H +F P + Sbjct: 346 MRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >2QKW-B nrPDB Length = 321 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 10/146 (6%) Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLLSGV 129 RHP++V + +I +Y G L + + S ++ G+ Sbjct: 93 RHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGL 152 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTV--GTPAYIAP 186 Y H+ I HRD+K N LLD + P KI DFG SK L STV GT YI P Sbjct: 153 HYLHTRAIIHRDVKSINILLDENFVP--KITDFGISKKGTELDQTHLSTVVKGTLGYIDP 210 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVML 212 E ++ K +DV+S GV L+ +L Sbjct: 211 EYFIKGRLTEK-SDVYSFGVVLFEVL 235 >4WUA-A nrPDB Length = 401 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 106/273 (38%), Gaps = 67/273 (24%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH--P 76 + RY ++ +G G+F L D K+ VA+K ++ + E EI +S+R+ P Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDP 99 Query: 77 N------IVR----FKEVILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQ 124 N +V+ FK + TH+ ++ E G L + I N + QQ Sbjct: 100 NDPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKIIQQ 158 Query: 125 LLSGVSYCHSM-QICHRDLKLENTLL-------------------DGSPAP--------- 155 +L G+ Y H+ +I H D+K EN LL G+P P Sbjct: 159 VLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAP 218 Query: 156 -------------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 ++KI D G + +H + T Y + EVL+ Y+ Sbjct: 219 ATAGNFLVNPLEPKNAEKLKVKIADLG--NACWVHKHFTEDIQTRQYRSLEVLIGSGYNT 276 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 AD+WS + + G Y FE P +Y + Sbjct: 277 P-ADIWSTACMAFELATGDYLFE-PHSGEEYTR 307 >3MY0-A nrPDB Length = 305 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 84/213 (39%), Gaps = 37/213 (17%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 V+ +G G +G + R E VAVK D+ + EI N LRH NI+ F Sbjct: 12 LVECVGKGRYG--EVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 84 VILT----PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH------ 133 +T T L +I Y G LY+ A G+++ H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYD-FLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT 128 Query: 134 --SMQICHRDLKLENTLLDGSPAPRLKIC--DFGYSKSSVLHSQPKS--------TVGTP 181 I HRD K N L+ + L+ C D G +V+HSQ VGT Sbjct: 129 QGKPAIAHRDFKSRNVLVKSN----LQCCIADLGL---AVMHSQGSDYLDIGNNPRVGTK 181 Query: 182 AYIAPEVLLRQEYDG-----KIADVWSCGVTLY 209 Y+APEVL Q K D+W+ G+ L+ Sbjct: 182 RYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW 214 >4XCU-A nrPDB Length = 300 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/234 (27%), Positives = 96/234 (41%), Gaps = 32/234 (13%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFG-VARLMRDKL------TKELVAVKYIE-------R 55 PLD DR K +G G FG V R + VAVK ++ Sbjct: 7 PLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL 66 Query: 56 GDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE 115 D + E ++I RH NI+ V L +I+E A+ G L E + Sbjct: 67 ADLVSEMEVMKLIG----RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGS 122 Query: 116 DEARFFFQQLLS-------GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS- 167 E F L+S G+ Y S + HRDL N L+ +KI DFG ++ Sbjct: 123 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--MKIADFGLARGV 180 Query: 168 -SVLHSQPKSTVGTPA-YIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + + + S P ++APE L + Y + +DVWS G+ L+ + +G P+ Sbjct: 181 HHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGILLWEIFTLGGSPY 233 >3LMG-A nrPDB Length = 344 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 25 VKDIGSGNFGVAR----LMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNI 78 +K +GSG FG + + K V +K IE G + + V ++ SL H +I Sbjct: 36 LKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHI 95 Query: 79 VRFKEVILTP-THLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 VR + L P + L ++ +Y G L + + + G + Q+ G+ Y Sbjct: 96 VRL--LGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSK------SSVLHSQPKSTVGTPAYIAPEVLL 190 + HR+L N LL SP+ ++++ DFG + +L+S+ K+ + ++A E + Sbjct: 154 MVHRNLAARNVLLK-SPS-QVQVADFGVADLLPPDDKQLLYSEAKTPI---KWMALESIH 208 Query: 191 RQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 +Y + +DVWS GVT++ +M GA P+ Sbjct: 209 FGKYTHQ-SDVWSYGVTVWELMTFGAEPY 236 >3GQL-A nrPDB Length = 326 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 97/236 (41%), Gaps = 47/236 (19%) Query: 20 DRYDFVKDIGSGNFGVARLMR---------DKLTKELVAVKYIER-------GDKIDENV 63 DR K +G G FG L +++TK VAVK ++ D I E Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDLSDLISEME 85 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----------- 112 ++I +H NI+ L +I+EYAS G L E + A R Sbjct: 86 MMKMIG----KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYCYNPS 140 Query: 113 ------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 S + Q+ G+ Y S + HRDL N L+ +KI DFG ++ Sbjct: 141 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLAR 198 Query: 167 S-SVLHSQPKSTVGT--PAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + K+T G ++APE L + Y + +DVWS GV L+ + +G P+ Sbjct: 199 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPY 253 >2H34-A nrPDB Length = 309 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 9/204 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHPN 77 Y + +G G G D + + +VA+K + D +QRE L+ P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V + L + M +G +L + G + A +Q+ S + H+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEVLLRQEYD 195 HRD+K EN L+ L DFG + ++ +Q +TVGT Y+APE + + Sbjct: 156 THRDVKPENILVSADDFAYL--VDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFSESHA 212 Query: 196 GKIADVWSCGVTLYVMLVGAYPFE 219 AD+++ LY L G+ P++ Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQ 236 >3ZBF-A nrPDB Length = 322 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 106/253 (41%), Gaps = 26/253 (10%) Query: 48 VAVKYIERGDKIDENVQ--REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGEL-- 103 VAVK +++G E ++ +E HPNI++ V L II+E GG+L Sbjct: 67 VAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT 126 Query: 104 YERICNAGRFSEDEARFFFQQ-----LLSGVSYCHSMQICHRDLKLENTLLDGS--PAPR 156 Y R F + G Y M HRDL N L+ +PR Sbjct: 127 YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPR 186 Query: 157 L-KICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 + KI DFG ++ + + + + ++APE L+ + + +DVWS G+ ++ +L Sbjct: 187 IVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQ-SDVWSFGILIWEIL 245 Query: 213 VGA---YPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 YP + +Y +T R L + PDD+ +L+++ + +P R + Sbjct: 246 TLGHQPYPAHSNLDVLNYVQTGGR-LEPPRNCPDDL------WNLMTQCWAQEPDQRPTF 298 Query: 270 PEIKTHSWFLKNL 282 I+ +N Sbjct: 299 HRIQDQLQLFRNF 311 >5TOS-A nrPDB Length = 395 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 87/206 (42%), Gaps = 22/206 (10%) Query: 28 IGSGNFGV---ARLMRDKLTKE------LVAVKYI-ERGDKIDENVQREIINHRSLRHPN 77 IG G FG L LT ++AVK + + G + EI L HPN Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL----LSGVSYCH 133 +V+ L H ++ E+ G L + G + + F + G+++ H Sbjct: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 Query: 134 S--MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV---LHSQPKSTVGTPAYIAPEV 188 S +++ +RD+K N LLD K+ DFG ++ L +GT Y APE Sbjct: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVG 214 + + + +DV+S GV L +L G Sbjct: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 >3TT0-A nrPDB Length = 382 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 67/236 (28%), Positives = 101/236 (42%), Gaps = 47/236 (19%) Query: 20 DRYDFVKDIGSGNFGVARLMR---------DKLTKELVAVKYIER-------GDKIDENV 63 DR K +G G FG L +++TK VAVK ++ D I E Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDLSDLISEME 126 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-----FSEDEA 118 ++I +H NI+ L +I+EYAS G L E + A R +S + + Sbjct: 127 MMKMIG----KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYSYNPS 181 Query: 119 RFFFQQLLS------------GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 +QL S G+ Y S + HRDL N L+ +KI DFG ++ Sbjct: 182 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLAR 239 Query: 167 S-SVLHSQPKSTVGT--PAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + K+T G ++APE L + Y + +DVWS GV L+ + +G P+ Sbjct: 240 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPY 294 >5LPZ-A nrPDB Length = 332 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 83/205 (40%), Gaps = 13/205 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 IGSG FG K + K I + D E+ ++H N+V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 88 PTHLAIIMEYASGGELYERICN---AG-RFSEDEARFFFQQLLSGVSYCH---SMQICHR 140 ++ E+ G L + + + AG + + R G+++ H S I HR Sbjct: 85 GDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHR 144 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 D+K N LLD + R + DFG ++ + H + GTP Y+ PE K Sbjct: 145 DMKSSNVLLDENLEAR--VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 202 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPE 222 DV+S GV L +L G P + P+ Sbjct: 203 -GDVYSYGVVLLELLTGKRPTDSPD 226 >5A46-A nrPDB Length = 386 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 97/236 (41%), Gaps = 47/236 (19%) Query: 20 DRYDFVKDIGSGNFGVARLMR---------DKLTKELVAVKYIER-------GDKIDENV 63 DR K +G G FG L +++TK VAVK ++ D I E Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDLSDLISEME 97 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----------- 112 ++I +H NI+ L +I+EYAS G L E + A R Sbjct: 98 MMKMIG----KHKNIINLLGACTQDGPLYVIVEYASKGNLREYL-QARRPPGLEYCYNPS 152 Query: 113 ------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 S + Q+ G+ Y S + HRDL N L+ +KI DFG ++ Sbjct: 153 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFGLAR 210 Query: 167 S-SVLHSQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + K+T G ++APE L + Y + +DVWS GV L+ + +G P+ Sbjct: 211 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPY 265 >1PY5-A nrPDB Length = 326 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 86/206 (41%), Gaps = 27/206 (13%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF---- 81 + IG G FG + R K E VAVK ++ + EI LRH NI+ F Sbjct: 35 ESIGKGRFG--EVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD 92 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH-------- 133 + T T L ++ +Y G L++ + E + SG+++ H Sbjct: 93 NKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA-SGLAHLHMEIVGTQG 151 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGY-----SKSSVLHSQPKSTVGTPAYIAPEV 188 I HRDLK +N L+ + I D G S + + P VGT Y+APEV Sbjct: 152 KPAIAHRDLKSKNILVKKNGT--CCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV 209 Query: 189 L-----LRQEYDGKIADVWSCGVTLY 209 L ++ K AD+++ G+ + Sbjct: 210 LDDSINMKHFESFKRADIYAMGLVFW 235 >5LPV-A nrPDB Length = 296 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 83/205 (40%), Gaps = 13/205 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 IGSG FG K + K I + D E+ ++H N+V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 88 PTHLAIIMEYASGGELYERICN---AG-RFSEDEARFFFQQLLSGVSYCH---SMQICHR 140 ++ E+ G L + + + AG + + R G+++ H S I HR Sbjct: 85 GDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHR 144 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 D+K N LLD + R + DFG ++ + H + GTP Y+ PE K Sbjct: 145 DMKSSNVLLDENLEAR--VSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTK 202 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPE 222 DV+S GV L +L G P + P+ Sbjct: 203 -GDVYSYGVVLLELLTGKRPTDSPD 226 >3UIM-A nrPDB Length = 326 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 91/213 (42%), Gaps = 17/213 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLT-KELVAVKYI--ERGDKIDENVQREIINHRSLRH 75 SD + +G G FG ++ + +L LVAVK + ER + Q E+ H Sbjct: 29 SDNFSNKNILGRGGFG--KVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH 86 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGE----LYERICNAGRFSEDEARFFFQQLLSGVSY 131 N++R + +TPT ++ Y + G L ER + + + G++Y Sbjct: 87 RNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 132 CHSM---QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAP 186 H +I HRD+K N LLD + DFG +K +T GT +IAP Sbjct: 147 LHDHCDPKIIHRDVKAANILLD--EEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 E L + K DV+ GV L ++ G F+ Sbjct: 205 EYLSTGKSSEK-TDVFGYGVMLLELITGQRAFD 236 >3PG1-A nrPDB Length = 362 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 63/258 (24%), Positives = 103/258 (39%), Gaps = 51/258 (19%) Query: 61 ENVQREI--INHRSLRHPNI-------VRFKEVILTPTHLAIIMEYASGGELY--ERICN 109 + V REI +NH HPNI V F+E + +L + ++ +RI Sbjct: 74 KRVLREIRLLNH--FHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIV- 130 Query: 110 AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 S ++F +L G+ H + HRDL N LL + + ICDF ++ Sbjct: 131 ---ISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILL--ADNNDITICDFNLAREDT 185 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGV---------------TLY----- 209 + V Y APE++++ + K+ D+WS G T Y Sbjct: 186 ADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNK 245 Query: 210 -VMLVGAYPFED-----PEEPRDY-RKTIQRILSVKYS--IPDDIRISPECCHLISRIFV 260 V +VG ED RDY R ++ + + ++ +P P LI+++ Sbjct: 246 IVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPT---ADPVALDLIAKMLE 302 Query: 261 ADPATRISIPEIKTHSWF 278 +P RIS + H +F Sbjct: 303 FNPQRRISTEQALRHPYF 320 >3V5Q-A nrPDB Length = 297 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 100/222 (45%), Gaps = 35/222 (15%) Query: 26 KDIGSGNFGVARL--------MRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHP 76 +++G G FG L +DK+ LVAVK ++ ++ QRE +L+H Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKM---LVAVKALKDPTLAARKDFQREAELLTNLQHE 77 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYE---------RICNAGRFSEDEARFFFQQLL- 126 +IV+F V L ++ EY G+L + I G+ + + Q+L Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 127 ------SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKST 177 SG+ Y S HRDL N L+ + +KI DFG S+ S+ + T Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLL--VKIGDFGMSRDVYSTDYYRVGGHT 195 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 + ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 196 MLPIRWMPPESIMYRKFTTE-SDVWSFGVILWEIFTYGKQPW 236 >6BSD-A nrPDB Length = 876 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 102/243 (41%), Gaps = 51/243 (20%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKY---IERGDKIDENVQ------------- 64 R F + +G G FG L ++LV++ + + +G + V+ Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARND 631 Query: 65 --REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR--- 119 +E+ L+ PNI+R V + L +I +Y G+L + +A + + A Sbjct: 632 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDL-NQFLSAHQLEDKAAEGAP 690 Query: 120 -----------------FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDF 162 Q+ SG+ Y ++ HRDL N L+ + +KI DF Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT--IKIADF 748 Query: 163 GYSKSSVLHSQPKSTVGTPA-----YIAPEVLLRQEYDGKIADVWSCGVTLY--VMLVGA 215 G S++ L++ V A ++A E +L ++ +DVW+ GVTL+ +ML A Sbjct: 749 GMSRN--LYAGDYYRVQGRAVLPIRWMAWECILMGKFT-TASDVWAFGVTLWEVLMLCRA 805 Query: 216 YPF 218 PF Sbjct: 806 QPF 808 >5GNK-A nrPDB Length = 297 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 23/213 (10%) Query: 22 YDFVKDIGSGNFGVA----RLMRDKLTKELVAVKYIERGD--KIDENVQREIINHRSLRH 75 + +K +GSG FG + + K VA+K + K ++ + E S+ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE--ARFFFQ---QLLSGVS 130 P++ R + LT T + +IM+ G L + + R +D +++ Q+ G++ Sbjct: 81 PHVCRLLGICLTST-VQLIMQLMPFGCLLDYV----REHKDNIGSQYLLNWCVQIAKGMN 135 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA---YIAPE 187 Y ++ HRDL N L+ +P +KI DFG +K + G ++A E Sbjct: 136 YLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 193 Query: 188 VLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFE 219 +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 194 SILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 225 >5SYS-A nrPDB Length = 286 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 23/192 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G FG + T VA+K ++ G E +E + LRH +V+ V+ + Sbjct: 26 LGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-S 83 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ---------QLLSGVSYCHSMQIC 138 + I+ EY S G L + F + E + + Q+ SG++Y M Sbjct: 84 EEPIYIVTEYMSKGSLLD-------FLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 136 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRDL+ N L+ + K+ DFG ++ ++ + + APE L + Sbjct: 137 HRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 194 Query: 197 KIADVWSCGVTL 208 K +DVWS G+ L Sbjct: 195 K-SDVWSFGILL 205 >5VDK-A nrPDB Length = 297 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 89/217 (41%), Gaps = 36/217 (16%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVK-----YIERGDKIDENVQREIINHRSL-RHPNI 78 V+ IG G FG +L + A+K + E + + + E+ H L HP++ Sbjct: 20 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSN--ENSALHEVYAHAVLGHHPHV 77 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERIC----NAGRFSEDEARFFFQQLLSGVSYCHS 134 VR+ H+ I EY +GG L I + F E + + Q+ G++Y H+ Sbjct: 78 VRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHN 137 Query: 135 MQICHRDLKLENTLL--------DG-------------SPAPRLKICDFGYSKSSVLHSQ 173 + H D+K N + G S KI D G++ S ++ Sbjct: 138 SSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI---NK 194 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYV 210 PK G ++A E+L AD+++ G+T+ V Sbjct: 195 PKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAV 231 >4F9B-A nrPDB Length = 361 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/174 (28%), Positives = 69/174 (39%), Gaps = 39/174 (22%) Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N++ K H+ I M Y E + I N+ F E R + L + H Sbjct: 81 NVMGVKYCFRKNDHVVIAMPYLEH-ESFLDILNSLSF--QEVREYMLNLFKALKRIHQFG 137 Query: 137 ICHRDLKLENTLLDGSPAPRLK---ICDFGYSKSS------VLH-----------SQPKS 176 I HRD+K N L + RLK + DFG ++ + +L SQ K Sbjct: 138 IVHRDVKPSNFLYN----RRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKC 193 Query: 177 TV------------GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 ++ GTP + APEVL + D+WS GV +L G YPF Sbjct: 194 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 247 >2DQ7-X nrPDB Length = 283 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 91/202 (45%), Gaps = 12/202 (5%) Query: 23 DFVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 +K +G+G FG V + TK VA+K ++ G E+ E + L+H +V+ Sbjct: 12 QLIKRLGNGQFGEVWMGTWNGNTK--VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 69 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNA-GR-FSEDEARFFFQQLLSGVSYCHSMQICH 139 V+ + + I+ EY + G L + + + GR Q+ +G++Y M H Sbjct: 70 YAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 128 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 RDL+ N L+ KI DFG ++ ++ + + APE L + K Sbjct: 129 RDLRSANILVGNGLI--CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 186 Query: 198 IADVWSCGVTLYVMLV-GAYPF 218 +DVWS G+ L ++ G P+ Sbjct: 187 -SDVWSFGILLTELVTKGRVPY 207 >3QUP-A nrPDB Length = 323 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 69/279 (24%), Positives = 112/279 (40%), Gaps = 46/279 (16%) Query: 21 RYDFVKDIGSGNFGVAR---LMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSL 73 ++ + +G G FG R L ++ + VAVK + + D I E RE + Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKML-KADIIASSDIEEFLREAACMKEF 82 Query: 74 RHPNIVRFKEVILTPTHLA------IIMEYASGGELYERICNAGRFSEDEARFFFQQLL- 126 HP++ + V L +I+ + G+L+ + A R E+ Q L+ Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLL-ASRIGENPFNLPLQTLVR 141 Query: 127 ------SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKIC--DFGYSK---SSVLHSQPK 175 G+ Y S HRDL N +L A + +C DFG S+ S + Q Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCML----AEDMTVCVADFGLSRKIYSGDYYRQGC 197 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRI 234 ++ ++A E L Y +DVW+ GVT++ +M G P+ E Y I Sbjct: 198 ASKLPVKWLALESLADNLYTVH-SDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG-- 254 Query: 235 LSVKYSIPDDIRISPECCH----LISRIFVADPATRISI 269 + ++ PEC L+ + + ADP R S Sbjct: 255 -------GNRLKQPPECMEEVYDLMYQCWSADPKQRPSF 286 >2H8H-A nrPDB Length = 535 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 23/192 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G FG + T VA+K ++ G E +E + LRH +V+ V+ + Sbjct: 275 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-S 332 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ---------QLLSGVSYCHSMQIC 138 + I+ EY S G L + F + E + + Q+ SG++Y M Sbjct: 333 EEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 385 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRDL+ N L+ + K+ DFG ++ ++ + + APE L + Sbjct: 386 HRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 443 Query: 197 KIADVWSCGVTL 208 K +DVWS G+ L Sbjct: 444 K-SDVWSFGILL 454 >4NT4-A nrPDB Length = 312 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 108/252 (42%), Gaps = 23/252 (9%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK-----IDENVQREI 67 M ++ + K IG GNFG RL ++ E VA+K K ++ + + Sbjct: 5 MAVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLL 64 Query: 68 INHRSLRHPNIVRFKEV-ILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQ 124 +H I R + + A+++E S +L+ IC A +FS +Q Sbjct: 65 GSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFN-IC-ARKFSLKTVLMIAKQ 122 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLK---ICDFGYSKS--------SVLHSQ 173 LL + Y HS + +RD+K EN L+ + R K I DFG +K + + + Sbjct: 123 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 182 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 KS GT Y++ + +E + D+ + G L G+ P++ + ++ Q+ Sbjct: 183 HKSLTGTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLKAD-TLKERYQK 240 Query: 234 ILSVKYSIPDDI 245 I K + P ++ Sbjct: 241 IGDTKRATPIEV 252 >6F3F-A nrPDB Length = 455 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 23/192 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G FG + T VA+K ++ G E +E + LRH +V+ V+ + Sbjct: 195 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-S 252 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ---------QLLSGVSYCHSMQIC 138 + I+ EY + G L + F + E + + Q+ SG++Y M Sbjct: 253 EEPIYIVTEYMNKGSLLD-------FLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV 305 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRDL+ N L+ + K+ DFG ++ ++ + + APE L + Sbjct: 306 HRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 363 Query: 197 KIADVWSCGVTL 208 K +DVWS G+ L Sbjct: 364 K-SDVWSFGILL 374 >2PL0-A nrPDB Length = 289 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 11/190 (5%) Query: 24 FVKDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFK 82 V+ +G+G FG V + TK VAVK +++G + E + L+H +VR Sbjct: 27 LVERLGAGQFGEVWMGYYNGHTK--VAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY 84 Query: 83 EVILTPTHLAIIMEYASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 V+ T + II EY G L + + + + + ++ Q+ G+++ HR Sbjct: 85 AVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 143 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 DL+ N L+ + + KI DFG ++ ++ + + APE + + K Sbjct: 144 DLRAANILVSDTLS--CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK- 200 Query: 199 ADVWSCGVTL 208 +DVWS G+ L Sbjct: 201 SDVWSFGILL 210 >3ZZW-A nrPDB Length = 289 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 56/227 (24%), Positives = 100/227 (44%), Gaps = 40/227 (17%) Query: 24 FVKDIGSGNFGVARLMRDKL-------TKELVAVKYIERGDKID----ENVQREIINHRS 72 F++++G FG ++ + L + VA+K ++ DK + E + E + Sbjct: 13 FMEELGEDRFG--KVYKGHLFGPAPGEQTQAVAIKTLK--DKAEGPLREEFRHEAMLRAR 68 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYE----RICNAGRFSEDEAR--------- 119 L+HPN+V V+ L++I Y S G+L+E R ++ S D+ R Sbjct: 69 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128 Query: 120 ---FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 Q+ +G+ Y S + H+DL N L+ +KI D G + V + Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV--YDKLNVKISDLGLFR-EVYAADYYK 185 Query: 177 TVGTPA----YIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 +G ++APE ++ ++ +D+WS GV L+ V G P+ Sbjct: 186 LLGNSLLPIRWMAPEAIMYGKFSID-SDIWSYGVVLWEVFSYGLQPY 231 >5OAT-A nrPDB Length = 411 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 30/169 (17%) Query: 128 GVSYCHSMQICHRDLKLENTLLDGS--PAPRLKICDFG---YSKSSVLHSQPKSTV---- 178 GV++ + I HRDLK +N LLD S +P L I DFG K++ L S P ++ Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGL-SLPYTSYEMDK 223 Query: 179 -GTPAYIAPEVLLRQEYDGKI-----ADVWSCGVTLYVMLVGAYPFEDPEEPRDYR---- 228 G A +APE++ ++ + AD+W+ G Y + PF P +++ Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEG 283 Query: 229 ----------KTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRI 267 IQ +++ + R+ PE + ++F+ P+T + Sbjct: 284 DLPKLPDEVPTVIQALVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWL 332 >3LZB-A nrPDB Length = 327 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 100/213 (46%), Gaps = 23/213 (10%) Query: 22 YDFVKDIGSGNFGVA----RLMRDKLTKELVAVKYIERGD--KIDENVQREIINHRSLRH 75 + +K +GSG FG + + K VA+K + K ++ + E S+ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 76 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE--ARFFFQ---QLLSGVS 130 P++ R + LT T + +I + G L + + R +D +++ Q+ G++ Sbjct: 77 PHVCRLLGICLTST-VQLITQLMPFGCLLDYV----REHKDNIGSQYLLNWCVQIAKGMN 131 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA---YIAPE 187 Y ++ HRDL N L+ +P +KI DFG +K + G ++A E Sbjct: 132 YLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 189 Query: 188 VLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFE 219 +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 190 SILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 221 >5C26-A nrPDB Length = 299 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 15/194 (7%) Query: 26 KDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVR 80 K++GSGNFG V + I + + D ++ E++ + L +P IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 + + + ++ME A G L + + + Q+ G+ Y HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 DL N LL KI DFG SK+ + +Q Y APE + ++ Sbjct: 152 DLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 208 Query: 196 GKIADVWSCGVTLY 209 K +DVWS GV ++ Sbjct: 209 SK-SDVWSFGVLMW 221 >2QLU-A nrPDB Length = 314 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 49/177 (27%), Positives = 72/177 (40%), Gaps = 23/177 (12%) Query: 31 GNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF----KEVIL 86 G FG + + +L + VAVK DK +REI + ++H N+++F K Sbjct: 26 GRFGC--VWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSN 83 Query: 87 TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-----------HSM 135 L +I + G L + + + +E + + G+SY H Sbjct: 84 LEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKP 142 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAYIAPEVL 189 I HRD K +N LL L DFG + P T VGT Y+APEVL Sbjct: 143 SIAHRDFKSKNVLLKSDLTAVL--ADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 >4BTK-A nrPDB Length = 337 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 15/212 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP-N 77 DR+ +K IG G FG D LT+E VA+K +E + + ++ E+ + L+ + Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDH 113 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYE--RICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 + RF ++M+ G L + R G F+ +Q+L + HS+ Sbjct: 114 VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 172 Query: 136 QICHRDLKLENTLLDGSPAPRLK--ICDFG----YSKSSVLHSQPKSTV---GTPAYIAP 186 HRD+K N + P+ K + DFG Y+ ++ P++ GT Y + Sbjct: 173 GFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASV 232 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 +E G+ D+WS L VG P+ Sbjct: 233 NAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 263 >3SOC-A nrPDB Length = 322 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 74/176 (42%), Gaps = 22/176 (12%) Query: 31 GNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF----KEVIL 86 G FG + + +L E VAVK DK + E+ + ++H NI++F K Sbjct: 35 GRFGC--VWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTS 92 Query: 87 TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC----------HSMQ 136 L +I + G L + + A S +E + + G++Y H Sbjct: 93 VDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA 151 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYIAPEVL 189 I HRD+K +N LL + I DFG + ++ VGT Y+APEVL Sbjct: 152 ISHRDIKSKNVLLKNNLTA--CIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 205 >4NFN-A nrPDB Length = 309 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 15/212 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP-N 77 DR+ +K IG G FG D LT+E VA+K +E + + ++ E+ + L+ + Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDH 78 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYE--RICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 + RF ++M+ G L + R G F+ +Q+L + HS+ Sbjct: 79 VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV 137 Query: 136 QICHRDLKLENTLLDGSPAPRLK--ICDFG----YSKSSVLHSQPKSTV---GTPAYIAP 186 HRD+K N + P+ K + DFG Y+ ++ P++ GT Y + Sbjct: 138 GFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASV 197 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 +E G+ D+WS L VG P+ Sbjct: 198 NAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 228 >4FL3-A nrPDB Length = 635 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 15/194 (7%) Query: 26 KDIGSGNFG-VARLMRDKLTKELVAVKYIERGDKIDENVQREIINH----RSLRHPNIVR 80 K++GSGNFG V + I + + D ++ E++ + L +P IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 + + + ++ME A G L + + + Q+ G+ Y HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 DL N LL KI DFG SK+ + +Q Y APE + ++ Sbjct: 494 DLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 550 Query: 196 GKIADVWSCGVTLY 209 K +DVWS GV ++ Sbjct: 551 SK-SDVWSFGVLMW 563 >2C47-A nrPDB Length = 313 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 95/215 (44%), Gaps = 32/215 (14%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH-------PNI 78 K IG GNFG RL ++ T E VA+K + I + + +R + P + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLSATEGVPQV 65 Query: 79 VRFKEVILTPTHLAIIMEY--ASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 F + A+++E S +L++ +C+ F+ QL++ + Y H+ Sbjct: 66 YYFGPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFTLKTVLMIAIQLITRMEYVHTKS 120 Query: 137 ICHRDLKLENTLLDGSPAPR----LKICDFGY--------SKSSVLHSQPKSTVGTPAYI 184 + +RD+K EN L+ G P + + I DFG +K + + + KS GT Y+ Sbjct: 121 LIYRDVKPENFLV-GRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 179 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 + L +E + D+ + G L G+ P++ Sbjct: 180 SINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 213 >2CHL-A nrPDB Length = 351 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 26/212 (12%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH----PNIVRF 81 K IG GNFG RL ++ T E VA+K +E + E ++ L P + F Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYF 94 Query: 82 KEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + A+++E S +L++ +C+ FS QL+S + Y HS + + Sbjct: 95 GPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIY 149 Query: 140 RDLKLENTLLDGSPAPR----LKICDFGY--------SKSSVLHSQPKSTVGTPAYIAPE 187 RD+K EN L+ G P + + I DF +K + + + KS GT Y++ Sbjct: 150 RDVKPENFLI-GRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSIN 208 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 L +E + D+ + G L G+ P++ Sbjct: 209 THLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 239 >5M07-A nrPDB Length = 276 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 81/208 (38%), Gaps = 26/208 (12%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLRHPN 77 Y V+ +G+ G L++ A+K + D+ QRE L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE----DEARFFFQQLLSGVSYCH 133 I+ + L I M+Y G + + + + RF E + + Y H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMAD--RFPAVLPVGEVLAIVTAVAGALDYAH 149 Query: 134 SMQICHRDLKLENTLLDGSPAP--RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 + HRD+ N +L A R+ + DFG + P+Y APE+ Sbjct: 150 QRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSAG 196 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFE 219 + DG+ AD ++ +T + GA P + Sbjct: 197 ADVDGR-ADQYALALTAIHLFAGAPPVD 223 >5XD6-A nrPDB Length = 305 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 97/234 (41%), Gaps = 32/234 (13%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKL-TKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 +D Y IG G++G R+ L + + A+K ++ + D+ ++ LR N Sbjct: 21 TDNYGSKSLIGEGSYG--RVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQEN 78 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR----FFFQQLLS------ 127 +V + + EYA G L++ + GR A+ + Q + Sbjct: 79 VVALLGYCVDGPLRVLAYEYAPNGSLHDIL--HGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 128 -GVSYCHSM---QICHRDLKLENTLL-DGSPAPRLKICDFGYSK-----SSVLHSQPKST 177 G+ Y H + HRD+K N LL D A KI DF S ++ LHS Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVA---KIADFDLSNQAPDMAARLHS--TRV 191 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 +GT Y APE + K +DV+S GV L +L G P D PR + + Sbjct: 192 LGTFGYHAPEYAMTGTLSTK-SDVYSFGVVLLELLTGRKPV-DHTLPRGQQSVV 243 >4TN6-A nrPDB Length = 318 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 101/249 (40%), Gaps = 37/249 (14%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-----------YIERGDKIDENVQREI 67 +RY + IGSG+FG L D E VA+K +IE KI + +Q + Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIE--SKIYKMMQGGV 63 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQL 125 I + + ++ME G E + N + +FS Q+ Sbjct: 64 ---------GIPTIRWCGAEGDYNVMVMELL--GPSLEDLFNFCSRKFSLKTVLLLADQM 112 Query: 126 LSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKS 176 +S + Y HS HRD+K +N L+ G + I DFG +K + + + K+ Sbjct: 113 ISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKN 172 Query: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS 236 GT Y + L E + D+ S G L +G+ P++ + R+ +RI Sbjct: 173 LTGTARYASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAATK-RQKYERISE 230 Query: 237 VKYSIPDDI 245 K S P ++ Sbjct: 231 KKMSTPIEV 239 >2CMW-A nrPDB Length = 310 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 93/215 (43%), Gaps = 31/215 (14%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH--------PN 77 K IG GNFG RL ++ T E VA+K + I + + +R + P Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 78 IVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 + F + A+++E S +L++ +C+ F+ QLLS + Y HS Sbjct: 62 VYYFGPC---GKYNAMVLELLGPSLEDLFD-LCDR-TFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 136 QICHRDLKLENTLLDGSPAPR---LKICDFGY--------SKSSVLHSQPKSTVGTPAYI 184 + +RD+K EN L+ + + I DFG +K + + + KS GT Y+ Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 + L +E + D+ + G L G+ P++ Sbjct: 177 SINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQ 210 >2PZI-A nrPDB Length = 681 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/142 (30%), Positives = 68/142 (47%), Gaps = 15/142 (10%) Query: 75 HPNIVR-FKEVILTPTHL----AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP+IV+ F V T H I+MEY G L + + EA + ++L + Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEILPAL 195 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 SY HS+ + + DLK EN +L +LK+ D G S ++S GTP + APE++ Sbjct: 196 SYLHSIGLVYNDLKPENIMLT---EEQLKLIDLG--AVSRINSF-GYLYGTPGFQAPEIV 249 Query: 190 LRQEYDGKIADVWSCGVTLYVM 211 + D+++ G TL + Sbjct: 250 --RTGPTVATDIYTVGRTLAAL 269 >5J0A-A nrPDB Length = 300 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 73/158 (46%), Gaps = 12/158 (7%) Query: 71 RSLRHPNIVRFKEVI-LTPTHLAIIMEYASGGELYERICNAGRFSED--EARFFFQQLLS 127 +SL HPNIV ++ L + MEY L + I + S+D A + L+ Sbjct: 69 KSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALN 128 Query: 128 ---GVSYCHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKST-VG 179 G+ Y H ++ H D+K N ++ G +KICD G S ++ + P++ +G Sbjct: 129 MARGLKYLHQEKKLLHGDIKSSNVVIKGD-FETIKICDVGVSLPLDENMEVTDPEACYIG 187 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYP 217 T + E + AD+++ G+TL+ M+ + P Sbjct: 188 TEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >4LRM-A nrPDB Length = 334 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 98/216 (45%), Gaps = 26/216 (12%) Query: 22 YDFVKDIGSGNFGVAR--LMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----- 74 + +K +GSG FG L + K + V E + +EI++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 75 --HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE--ARFFFQ---QLLS 127 +P++ R + LT T + +I + G L + + R +D +++ Q+ Sbjct: 81 PGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYV----REHKDNIGSQYLLNWCVQIAK 135 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA---YI 184 G++Y ++ HRDL N L+ +P +KI DFG +K + G ++ Sbjct: 136 GMNYLEDRRLVHRDLAARNVLVK-TPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 193 Query: 185 APEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFE 219 A E +L + Y + +DVWS GVT++ +M G+ P++ Sbjct: 194 ALESILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYD 228 >4Y12-A nrPDB Length = 375 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 43/142 (30%), Positives = 68/142 (47%), Gaps = 15/142 (10%) Query: 75 HPNIVR-FKEVILTPTHL----AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP+IV+ F V T H I+MEY G L + + EA + ++L + Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEILPAL 234 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 SY HS+ + + DLK EN +L +LK+ D G S ++S GTP + APE++ Sbjct: 235 SYLHSIGLVYNDLKPENIMLT---EEQLKLIDLG--AVSRINSF-GYLYGTPGFQAPEIV 288 Query: 190 LRQEYDGKIADVWSCGVTLYVM 211 + D+++ G TL + Sbjct: 289 --RTGPTVATDIYTVGRTLAAL 308 >3SV0-A nrPDB Length = 483 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 93/226 (41%), Gaps = 42/226 (18%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 +++ + IGSG+FG L + T E VA+K ENV+ +HP + Sbjct: 6 GNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL--------ENVK--------TKHPQL 49 Query: 79 V---RFKEVILTPTHLAIIMEYASGGEL-----------YERICN--AGRFSEDEARFFF 122 + + ++ T + + + G+ E + N + + S Sbjct: 50 LYESKIYRILQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLA 109 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQ 173 Q+++ V + HS HRD+K +N L+ G A ++ I DFG +K + + + Sbjct: 110 DQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRE 169 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 K+ GT Y + L E + D+ S G L L G+ P++ Sbjct: 170 NKNLTGTARYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQ 214 >3QD2-B nrPDB Length = 332 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 16/104 (15%) Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGY--------SKSSVLHSQ 173 F Q+ V + HS + HRDLK N +K+ DFG + +VL Sbjct: 170 FIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPM 227 Query: 174 PK-----STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML 212 P VGT Y++PE + Y K+ D++S G+ L+ +L Sbjct: 228 PAYATHTGQVGTKLYMSPEQIHGNNYSHKV-DIFSLGLILFELL 270 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 2/62 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK--IDENVQREIINHRSLRHPNIV 79 ++ ++ +G G FGV ++K+ A+K I ++ E V RE+ L HP IV Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 67 Query: 80 RF 81 R+ Sbjct: 68 RY 69 >3AOX-A nrPDB Length = 344 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 87/217 (40%), Gaps = 26/217 (11%) Query: 24 FVKDIGSGNFG------VARLMRDKLTKELVAVKYI----ERGDKIDENVQREIINHRSL 73 ++ +G G FG V+ + D + VAVK + D++D ++ II+ Sbjct: 51 LIRGLGHGAFGEVYEGQVSGMPNDPSPLQ-VAVKTLPEVCSEQDELDFLMEALIIS--KF 107 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYE-------RICNAGRFSEDEARFFFQQLL 126 H NIVR V L I++E +GG+L R + + + + Sbjct: 108 NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIA 167 Query: 127 SGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSK---SSVLHSQPKSTVGTPA 182 G Y HRD+ N LL P KI DFG ++ + + + + Sbjct: 168 CGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVK 227 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPF 218 ++ PE + + K D WS GV L+ + +G P+ Sbjct: 228 WMPPEAFMEGIFTSK-TDTWSFGVLLWEIFSLGYMPY 263 >4MWI-A nrPDB Length = 294 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 102/243 (41%), Gaps = 35/243 (14%) Query: 59 IDENVQREIINHRSLRHPNIVRFKEVIL----TPTHLAIIMEYASGGELYERICNAGRFS 114 + + +EI + PNI+R + + TP +I+MEY G L E + + Sbjct: 66 VRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLT 125 Query: 115 EDEARFFFQQLLSGVSYCHSMQI--CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 + G+ H + H ++ N L+ + ++K+ F K+ S Sbjct: 126 LGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLV--TQGYQVKLAGFELRKTQTSMS 183 Query: 173 -----QPKSTVGTPAYIAPEVL--LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPR 225 + V + AY++P+ L + +YD K ++++S G+ L+ + G PF+ + Sbjct: 184 LGTTREKTDRVKSTAYLSPQELEDVFYQYDVK-SEIYSFGIVLWEIATGDIPFQGCNSEK 242 Query: 226 DYRKTIQRILSVKYS-------IPDDIRISPECCHLISRIFVADPATRISIPEI-KTHSW 277 I+++++VK P ++R +I DP+ R S+ EI K S Sbjct: 243 -----IRKLVAVKRQQEPLGEDCPSELR------EIIDECRAHDPSVRPSVDEILKKLST 291 Query: 278 FLK 280 F K Sbjct: 292 FSK 294 >5X1R-A nrPDB Length = 302 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/280 (21%), Positives = 109/280 (38%), Gaps = 58/280 (20%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIE--------------RGD 57 +P + + ++ + IG G FG+ D + +A+K Y+ RG+ Sbjct: 14 LPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGE 73 Query: 58 KIDENVQREI------------INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYE 105 + + Q + +H L H ++RF E T + ++ SG L Sbjct: 74 RFGKTFQAGLNSFIQEARLLARFSHPGLLH--VLRFWEENGTAY---MGTQFYSGTTLKN 128 Query: 106 -RICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGY 164 + + E R L S ++ H HRD+ L+N + S P L DFG Sbjct: 129 LQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVL--LDFGS 186 Query: 165 SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK---IADVWSCGVTLYVMLVGAYP---- 217 ++ + + ++ + AP + DG+ D+++ G L+ ++VG+ P Sbjct: 187 ARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSV 246 Query: 218 ---FEDPEEPRDYR----------KTIQRILSVKYSIPDD 244 ED +P R +T+ R L++K P+D Sbjct: 247 VRSIEDSYQPLTERRPAGYSPELLRTVDRALALK---PED 283 >6J5U-C nrPDB Length = 426 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 13/190 (6%) Query: 47 LVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYE 105 +VAVK ++ G + + E+ L HPN+V + ++ E+ G L Sbjct: 120 VVAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLEN 179 Query: 106 RICNAGRFSEDEARFFFQQL--LSGVSYCHSM--QICHRDLKLENTLLDGSPAPRLKICD 161 + G A + G+++ H Q+ +RD K N LLD K+ D Sbjct: 180 HLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDAD--FNAKLSD 237 Query: 162 FGYSKSSV----LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYP 217 FG +K+ H K +GT Y APE + K +DV+S GV L ++ G Sbjct: 238 FGLAKAGPTGDNTHVSTK-VIGTHGYAAPEYVATGRLTAK-SDVYSFGVVLLELISGRRA 295 Query: 218 FEDPEEPRDY 227 ++ +Y Sbjct: 296 MDNSNGGNEY 305 >5FQD-C nrPDB Length = 341 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 98/252 (38%), Gaps = 43/252 (17%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 +Y V+ IGSG+FG L + E VAVK + + RHP + Sbjct: 18 GGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK----------------LESQKARHPQL 61 Query: 79 V---RFKEVILTPTHLAIIMEYASG-----------GELYERICN--AGRFSEDEARFFF 122 + + +++ + I Y G E + N + RF+ Sbjct: 62 LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLA 121 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQ 173 Q++S + Y H+ HRD+K +N L+ G +L + DFG +K + + + Sbjct: 122 DQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRE 181 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 K+ GT Y + L E + D+ S G L + P++ + +K ++ Sbjct: 182 DKNLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQK-YEK 239 Query: 234 ILSVKYSIPDDI 245 I K S P ++ Sbjct: 240 ISEKKMSTPVEV 251 >1CSN-A nrPDB Length = 298 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 105/238 (44%), Gaps = 25/238 (10%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH----PN 77 Y + IG G+FGV + L + VA+K+ R + ++ E ++ L PN Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQ-LRDEYRTYKLLAGCTGIPN 70 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQ 136 + F + L H ++++ G L + + GR FS +Q+L+ V H Sbjct: 71 VYYFGQEGL---HNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKS 126 Query: 137 ICHRDLKLENTLLDGSP----APRLKICDFGY--------SKSSVLHSQPKSTVGTPAYI 184 + +RD+K +N L+ G P A + + DFG +K + + + K+ GT Y+ Sbjct: 127 LVYRDIKPDNFLI-GRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 + L +E + D+ + G L G+ P++ + + +K +RI K S P Sbjct: 186 SINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQK-YERIGEKKQSTP 241 >5CLR-A nrPDB Length = 451 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 54/99 (54%), Gaps = 14/99 (14%) Query: 119 RFFFQQLLSGVSYCHSMQ------ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 + F++ L +S CH ++ + HRDLK N +LD L DFG S S Sbjct: 173 KHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHL--VDFGSSSSD---K 227 Query: 173 QPK-STVGTPAYIAPEVLLRQEYDG--KIADVWSCGVTL 208 +PK ++ GT +Y+APE+ ++++ +++D+++ +L Sbjct: 228 EPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSL 266 >4XHL-A nrPDB Length = 394 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 13/138 (9%) Query: 112 RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--- 167 RFS Q+ + Y H HRD+K +N L+ G + + DFG SK Sbjct: 99 RFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 Query: 168 -----SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE 222 + + + KS GT Y + L E + D+ S G L G+ P++ + Sbjct: 159 FNTHRHIPYRENKSLTGTARYASVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLK 217 Query: 223 ---EPRDYRKTIQRILSV 237 + + Y + +++ L+V Sbjct: 218 ATTKKQKYDRIMEKKLNV 235 >6BFN-A nrPDB Length = 342 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 81/209 (38%), Gaps = 26/209 (12%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERG-----DKIDENVQREIINHRSLRHPNIVRF 81 IG G FG + R + + AVK ++ + ++ E+ RHPNIV F Sbjct: 29 KIGEGGFGC--VYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 82 KEVILTPTHLAIIMEYASGGELYERI-CNAGR---FSEDEARFFFQQLLSGVSYCH--SM 135 ++ + G L +R+ C S + + + H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVGTPAYIA 185 + H D+K N LLD P+L DFG ++ S + ++ ++ GT AY+ Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLG--DFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL- 203 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVG 214 PE ++ D +S GV + L G Sbjct: 204 PEEYIKTGRLAVDTDTFSFGVVVLETLAG 232 >4L00-A nrPDB Length = 304 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 65/157 (41%), Gaps = 10/157 (6%) Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF-FFQQLLSGV 129 R + H +IV V + ++ E+ GG L + +F +QL S + Sbjct: 87 RQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASAL 146 Query: 130 SYCHSMQICHRDLKLENTLL-----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 SY + H ++ +N LL D P +K+ D G +VL Q + +I Sbjct: 147 SYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIP-ITVLSRQ--ECIERIPWI 203 Query: 185 APEVLLRQEYDGKIADVWSCGVTLY-VMLVGAYPFED 220 APE + + AD WS G TL+ + G P +D Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKD 240 >4XHH-A nrPDB Length = 403 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 11/127 (8%) Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQP 174 Q++ V Y H HRD+K +N L+ G + + DFG SK + + + Sbjct: 111 QMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYREN 170 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 KS GT Y + L E + D+ S G L G+ P++ + +K RI Sbjct: 171 KSLTGTARYASVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQK-YDRI 228 Query: 235 LSVKYSI 241 L K I Sbjct: 229 LEKKLCI 235 >3G2F-A nrPDB Length = 336 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 78/197 (39%), Gaps = 32/197 (16%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 D D ++ IG G +G + + L + VAVK ++ + ++ I + H N Sbjct: 11 DLDNLKLLELIGRGRYGA--VYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDN 68 Query: 78 IVRF---KEVILTPTHLA--IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 I RF E + + ++MEY G L + + R + G++Y Sbjct: 69 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLA-HSVTRGLAYL 127 Query: 133 HSM---------QICHRDLKLENTLL--DGSPAPRLKICDFGYS---------KSSVLHS 172 H+ I HRDL N L+ DG+ I DFG S + + Sbjct: 128 HTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV----ISDFGLSMRLTGNRLVRPGEEDN 183 Query: 173 QPKSTVGTPAYIAPEVL 189 S VGT Y+APEVL Sbjct: 184 AAISEVGTIRYMAPEVL 200 >6EQI-C nrPDB Length = 433 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 43/154 (27%), Positives = 69/154 (44%), Gaps = 25/154 (16%) Query: 128 GVSYCHSMQICHRDLKLENTLLD---GSPAPRLKICDFGYS---KSSVL----HSQPKST 177 V++ + I HRDLK +N L+D G P + I DFG K + L S+ + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 178 VGTPAYIAPEVLLRQE-----YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 G A +APE+ + + K +D+W+ G Y + PF Y KT+ Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPF--------YDKTM- 289 Query: 233 RILSVKYSIPDDIRISPECCHLISRIFVADPATR 266 ++LS Y +D+ P+ I R V++ +R Sbjct: 290 KLLSKSYK-EEDLPELPDTIPFIIRNLVSNMLSR 322 >6EWX-A nrPDB Length = 484 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 77/214 (35%), Gaps = 61/214 (28%) Query: 102 ELYER-ICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL----------- 149 E+YER +C F QL +G+ + I HRDL LEN LL Sbjct: 206 EVYERRVC-----------FLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGP 254 Query: 150 ------------------------DGSPA----PRLKICDFGYSKSSVLHSQPKSTVGTP 181 G P PRL I +F +K + + Sbjct: 255 SANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQ 314 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE--PRDYRKTIQRILSVKY 239 A +APE++ +Y + D + G+ +Y +L PFE + RDYR+ L Sbjct: 315 ARLAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPL---- 368 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 P SP L + ADP RI I E K Sbjct: 369 --PTLSLYSPGLQQLAHLLLEADPIKRIRIGEAK 400 >4JRN-A nrPDB Length = 372 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 11/102 (10%) Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKST 177 + Q + V+ + I H D+K N LL DG RL + DFG + +++ Sbjct: 206 YLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDG----RLFLGDFGTYR---INNSVGRA 258 Query: 178 VGTPAYIAPEVLLRQEYDGKI--ADVWSCGVTLYVMLVGAYP 217 +GTP Y PE + D W G+TLY + P Sbjct: 259 IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP 300 >6BHC-A nrPDB Length = 438 Score = 34.7 bits (78), Expect = 0.073, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 68/166 (40%), Gaps = 26/166 (15%) Query: 127 SGVSYCHSMQICHRDLKLENTLL-------------DGSPAP------RLKICDFGYSKS 167 SG+ + + H DL+LEN LL P P RL + +F +K Sbjct: 189 SGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQ 248 Query: 168 SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 P+ + + +APE++ +Y K D + G+ +Y ML PF++ E ++ Sbjct: 249 KSHLVDPE-ILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKER 305 Query: 228 RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 T + + + P + L S + +P+ RI I + K Sbjct: 306 EYTRADLPRIPFRSPYSRGLQ----QLASCLLNPNPSERILISDAK 347 >5UU1-A nrPDB Length = 324 Score = 33.9 bits (76), Expect = 0.100, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 69/167 (41%), Gaps = 20/167 (11%) Query: 18 DSDRYDFVKDIGSGNFGVARLMR-----DKLTKELVAVKYIERGDKIDE----------N 62 + +++ K IGSG FG+ L +K + +V V+Y E G E + Sbjct: 14 EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKD 73 Query: 63 VQREIINHRSLRHPNIVRFKEVILTP----THLAIIMEYASGGELYERICNAGRFSEDEA 118 ++ I + L + I F LT ++ ++ME G +L + G F + Sbjct: 74 CIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTV 132 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYS 165 ++L + Y H + H D+K N LL ++ + D+G S Sbjct: 133 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 >2GLJ-A nrPDB Length = 461 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 25/40 (62%) Query: 211 MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 +L+G+ P +D EE + + I +IL+ KY I ++ +S E Sbjct: 197 ILIGSIPLKDGEEKQKVKHNIMKILNEKYDISEEDFVSAE 236 >5UV4-A nrPDB Length = 311 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 41/180 (22%), Positives = 74/180 (41%), Gaps = 13/180 (7%) Query: 47 LVAVKYIERG-DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIM--EYASGGEL 103 ++ VK+++ G K + REI S+RHPN+V + P IM +YA L Sbjct: 51 MLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSL 110 Query: 104 YERIC-----NAGRFSEDEARFFFQQLLSGVSYCHSMQIC-HRDLKLENTLLDGSPAPRL 157 + N S + + + Y H+ ++ H ++K N L+ S P Sbjct: 111 STYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNS-TPSA 169 Query: 158 KICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI-ADVWSCGVTLYVMLVG 214 + D+ + + + ++ G Y PE + + +DV++ GV L +L G Sbjct: 170 LVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTG 229 >5VE6-A nrPDB Length = 492 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 71/205 (34%), Gaps = 59/205 (28%) Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLL------------------------------ 149 F QL +G+ + I HRDL LEN LL Sbjct: 212 FLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAA 271 Query: 150 ---------DGSPA----------PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 PA PRL I +F +K + + A +APE++ Sbjct: 272 PPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVS 331 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE--PRDYRKTIQRILSVKYSIPDDIRIS 248 +Y + D + G+ +Y +L PFE + RDYR Q L +P S Sbjct: 332 ASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYR---QEDLP---PLPALSLYS 383 Query: 249 PECCHLISRIFVADPATRISIPEIK 273 P L + ADP RI I E K Sbjct: 384 PGLQQLAHLLLEADPIKRIRIGEAK 408 >2RSV-A nrPDB Length = 403 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 2/62 (3%) Query: 102 ELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICD 161 ++YE NA RFS ++L + Y H + H D+K N LL+ ++ + D Sbjct: 147 KIYE--ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 204 Query: 162 FG 163 +G Sbjct: 205 YG 206 >2LAV-A nrPDB Length = 361 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 2/62 (3%) Query: 102 ELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICD 161 ++YE NA RFS ++L + Y H + H D+K N LL+ ++ + D Sbjct: 140 KIYE--ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVD 197 Query: 162 FG 163 +G Sbjct: 198 YG 199 >6G4J-A nrPDB Length = 315 Score = 30.8 bits (68), Expect = 0.88, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 4/69 (5%) Query: 95 MEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPA 154 MEY G L + + + G + QLLS +S H DLK +N ++ G PA Sbjct: 105 MEYIKGPLLLKYVSDKG---AEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPA 161 Query: 155 PRLKICDFG 163 R++ D G Sbjct: 162 -RIRCIDVG 169 >2IRM-A nrPDB Length = 358 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/52 (26%), Positives = 25/52 (48%) Query: 270 PEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAV 321 P + T + +L AD MN+ QF+ Q + SL+ + + S A + + Sbjct: 111 PHVATKTAIQLHLSADGMNQYEISQQFENVLQKLDSLNNALSVGSSAVLALI 162 >5C01-A nrPDB Length = 342 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 61/157 (38%), Gaps = 17/157 (10%) Query: 123 QQLLSGVSYCHSM-----QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST 177 QQL S +SY + +C R++ L L +P +K+ D G ++ + Sbjct: 187 QQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVER 246 Query: 178 VGTPAYIAPEVLLRQEYDGKIA-DVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRIL 235 + ++APE L A D W G TL + G P + P + QR Sbjct: 247 I---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQS-RSPSEKEHFYQR-- 300 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 ++ +P+ P+ L S+ +P R S I Sbjct: 301 --QHRLPEP--SCPQLATLTSQCLTYEPTQRPSFRTI 333 >4WOV-A nrPDB Length = 317 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 61/157 (38%), Gaps = 17/157 (10%) Query: 123 QQLLSGVSYCHSM-----QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST 177 QQL S +SY + +C R++ L L +P +K+ D G ++ + Sbjct: 164 QQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVER 223 Query: 178 VGTPAYIAPEVLLRQEYDGKIA-DVWSCGVTLY-VMLVGAYPFEDPEEPRDYRKTIQRIL 235 + ++APE L A D W G TL + G P + P + QR Sbjct: 224 I---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQS-RSPSEKEHFYQR-- 277 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 ++ +P+ P+ L S+ +P R S I Sbjct: 278 --QHRLPEP--SCPQLATLTSQCLTYEPTQRPSFRTI 310 >3G6S-A nrPDB Length = 267 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 18/36 (50%) Query: 225 RDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFV 260 +D KT R+ V Y+ D RI E C I IFV Sbjct: 193 KDAYKTAARVTGVDYTFHDFARIPAEDCEKIDFIFV 228 >5DMZ-A nrPDB Length = 365 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 17/110 (15%) Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGS---------PAPRLKICDFGYSKSSVLH 171 F ++L + H +I H D+K +N +L + L + D G S L Sbjct: 177 FAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLF 236 Query: 172 SQPKSTVGTP-----AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAY 216 PK T+ T + E+L + ++ +I D + T+Y ML G Y Sbjct: 237 --PKGTIFTAKCETSGFQCVEMLSNKPWNYQI-DYFGVAATVYCMLFGTY 283 >4TR8-A nrPDB Length = 383 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 23/44 (52%) Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 G L V LVG ED EP + ++++ + S+P+D+ I Sbjct: 61 TGTDLEVELVGRVVLEDAAEPGEITVPARKLMDICKSLPNDVLI 104 >3ICE-A nrPDB Length = 422 Score = 27.3 bits (59), Expect = 10.0, Method: Compositional matrix adjust. Identities = 17/63 (26%), Positives = 28/63 (44%), Gaps = 10/63 (15%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV 63 V TG +D +H R+ FG AR + + + ++A I+ G K+DE + Sbjct: 285 GKVLTGGVDANALHRPKRF----------FGAARNVEEGGSLTIIATALIDTGSKMDEVI 334 Query: 64 QRE 66 E Sbjct: 335 YEE 337 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3UC3-A nrPDB 540 e-154 3ZUT-A nrPDB 470 e-133 5WAX-A nrPDB 445 e-125 3UDB-A nrPDB 440 e-124 4REW-A nrPDB 356 9e-99 4CFH-A nrPDB 354 3e-98 4RED-A nrPDB 349 8e-97 4CFF-A nrPDB 337 5e-93 5EZV-A nrPDB 331 3e-91 3HZT-A nrPDB 330 5e-91 5JN2-A nrPDB 324 3e-89 3LIJ-A nrPDB 319 1e-87 3DXN-A nrPDB 318 2e-87 3NCG-A nrPDB 312 1e-85 3Q5I-A nrPDB 311 4e-85 5ES1-A nrPDB 310 6e-85 2QNJ-A nrPDB 309 1e-84 4MVF-A nrPDB 308 2e-84 5FG8-A nrPDB 307 4e-84 3MA6-A nrPDB 307 5e-84 2VN9-A nrPDB 307 5e-84 3DFA-A nrPDB 307 6e-84 5KZ7-A nrPDB 306 8e-84 5IG1-A nrPDB 306 1e-83 4CZT-A nrPDB 304 3e-83 2BDW-A nrPDB 304 4e-83 4YZB-A nrPDB 304 4e-83 3H4J-B nrPDB 303 6e-83 2YZA-A nrPDB 303 7e-83 3MN3-A nrPDB 303 9e-83 2V7O-A nrPDB 302 2e-82 3BHH-A nrPDB 302 2e-82 5U6Y-A nrPDB 302 2e-82 3KK8-A nrPDB 301 3e-82 2JC6-A nrPDB 301 4e-82 4RGJ-A nrPDB 300 6e-82 2VZ6-A nrPDB 300 6e-82 4D28-A nrPDB 300 8e-82 2W4O-A nrPDB 297 4e-81 3SOA-A nrPDB 296 1e-80 4FG9-A nrPDB 296 2e-80 5YKS-A nrPDB 294 6e-80 3MV5-A nrPDB 293 7e-80 2JAM-A nrPDB 292 1e-79 3F3Z-A nrPDB 291 4e-79 2HAK-A nrPDB 289 2e-78 6C9D-A nrPDB 288 2e-78 4CQG-A nrPDB 288 3e-78 2JDO-A nrPDB 287 4e-78 4YNZ-A nrPDB 285 2e-77 5KCV-A nrPDB 285 2e-77 4UZD-A nrPDB 285 2e-77 4D2V-A nrPDB 285 3e-77 1FOT-A nrPDB 285 3e-77 3HDN-A nrPDB 283 1e-76 2J90-A nrPDB 282 1e-76 3D2K-A nrPDB 282 2e-76 4NIF-A nrPDB 281 3e-76 2YCR-A nrPDB 281 4e-76 2BPM-A nrPDB 280 9e-76 5XZW-A nrPDB 279 1e-75 5D9K-A nrPDB 277 4e-75 4JG6-A nrPDB 276 8e-75 3I6U-A nrPDB 275 2e-74 3GUB-A nrPDB 275 2e-74 3UTO-A nrPDB 275 3e-74 5JZN-A nrPDB 274 3e-74 2YAB-A nrPDB 274 5e-74 6FDY-U nrPDB 272 1e-73 1PHK-A nrPDB 272 1e-73 1KOA-A nrPDB 272 1e-73 2Z7Q-A nrPDB 272 2e-73 4L42-A nrPDB 272 2e-73 3TAC-A nrPDB 271 3e-73 6CMJ-A nrPDB 271 4e-73 5N23-A nrPDB 271 4e-73 2Y7J-A nrPDB 270 6e-73 3IS5-A nrPDB 270 6e-73 4PDS-A nrPDB 270 8e-73 1KOB-A nrPDB 269 2e-72 2A27-A nrPDB 269 2e-72 5X3F-B nrPDB 268 2e-72 1ZWS-A nrPDB 268 3e-72 4WB7-A nrPDB 267 4e-72 4RLP-A nrPDB 267 5e-72 6E9W-A nrPDB 267 6e-72 3COM-A nrPDB 267 8e-72 3KN6-A nrPDB 266 9e-72 1VZO-A nrPDB 266 1e-71 2X4F-A nrPDB 265 2e-71 3NIZ-A nrPDB 265 2e-71 2HW6-A nrPDB 264 6e-71 4LG4-A nrPDB 263 9e-71 5FET-A nrPDB 263 1e-70 5DYK-A nrPDB 262 1e-70 4JXF-A nrPDB 262 1e-70 4I6B-A nrPDB 262 2e-70 1NY3-A nrPDB 262 2e-70 5YV8-A nrPDB 262 2e-70 3ORZ-A nrPDB 262 2e-70 4B6L-A nrPDB 262 3e-70 2OZA-A nrPDB 261 4e-70 4RA4-A nrPDB 261 4e-70 3KA0-A nrPDB 261 4e-70 6AO5-A nrPDB 260 5e-70 6ED6-A nrPDB 260 5e-70 4QMW-A nrPDB 260 8e-70 4EWQ-A nrPDB 260 8e-70 3DB8-A nrPDB 259 1e-69 2BRG-A nrPDB 259 2e-69 5J5T-A nrPDB 259 2e-69 6FD3-A nrPDB 258 3e-69 3TXO-A nrPDB 257 4e-69 4CSV-A nrPDB 257 5e-69 3OHT-A nrPDB 257 5e-69 4AGU-A nrPDB 257 7e-69 4B8L-A nrPDB 255 2e-68 6GU6-A nrPDB 255 2e-68 6DTL-A nrPDB 254 4e-68 5F9E-A nrPDB 254 4e-68 2OU7-A nrPDB 254 4e-68 4FIE-A nrPDB 254 5e-68 4AU8-A nrPDB 253 7e-68 3FXW-A nrPDB 253 8e-68 3DAK-A nrPDB 253 8e-68 4KRC-A nrPDB 253 9e-68 1CM8-A nrPDB 253 9e-68 4J52-A nrPDB 253 1e-67 6CKI-A nrPDB 252 1e-67 4JDH-A nrPDB 252 1e-67 1UA2-A nrPDB 252 2e-67 3GC9-A nrPDB 252 2e-67 2Q0N-A nrPDB 252 2e-67 3PFQ-A nrPDB 252 2e-67 3LM0-A nrPDB 252 2e-67 3A8W-A nrPDB 252 2e-67 4KS7-A nrPDB 252 2e-67 4BBM-A nrPDB 252 2e-67 4AF3-A nrPDB 252 3e-67 4XBR-A nrPDB 251 3e-67 3HKO-A nrPDB 251 3e-67 6QAU-A nrPDB 251 4e-67 4C0T-A nrPDB 251 4e-67 2F57-A nrPDB 250 5e-67 4WNO-A nrPDB 250 5e-67 5LOH-A nrPDB 250 7e-67 1V0B-A nrPDB 250 8e-67 2I0E-A nrPDB 250 9e-67 6BDL-A nrPDB 249 2e-66 5Z33-A nrPDB 248 3e-66 4XEY-B nrPDB 248 3e-66 4FZF-B nrPDB 248 4e-66 3Q53-A nrPDB 248 4e-66 3ZDU-A nrPDB 247 4e-66 3NYO-A nrPDB 247 4e-66 2FO0-A nrPDB 247 5e-66 3TKU-A nrPDB 247 5e-66 4MYG-A nrPDB 247 6e-66 2XIK-A nrPDB 247 8e-66 6CCF-A nrPDB 246 9e-66 4IC8-A nrPDB 246 9e-66 4AW2-A nrPDB 246 9e-66 4QNY-A nrPDB 246 9e-66 4APC-A nrPDB 246 1e-65 5Y86-A nrPDB 246 1e-65 3QA8-A nrPDB 245 2e-65 5AIR-A nrPDB 245 2e-65 4QTB-A nrPDB 245 3e-65 2F9G-A nrPDB 244 4e-65 3GC0-A nrPDB 244 5e-65 4ZSG-A nrPDB 244 7e-65 3E7O-A nrPDB 244 7e-65 5AWM-A nrPDB 242 1e-64 5D7A-A nrPDB 242 2e-64 5NGU-A nrPDB 242 3e-64 1G3N-A nrPDB 241 4e-64 5DBX-A nrPDB 240 6e-64 4TNB-A nrPDB 240 8e-64 2XYN-A nrPDB 240 9e-64 6E2O-A nrPDB 239 1e-63 2XS0-A nrPDB 239 1e-63 6NPU-A nrPDB 239 1e-63 2UV2-A nrPDB 239 2e-63 6BXI-A nrPDB 239 2e-63 2VD5-A nrPDB 238 2e-63 3PPZ-A nrPDB 238 2e-63 6CQF-A nrPDB 238 2e-63 5UUU-A nrPDB 238 3e-63 3OZ6-A nrPDB 237 4e-63 3PVW-A nrPDB 237 4e-63 6HXF-B nrPDB 237 4e-63 1JNK-A nrPDB 237 7e-63 2H8H-A nrPDB 237 8e-63 4FR4-A nrPDB 236 9e-63 1TKI-A nrPDB 236 1e-62 6F3F-A nrPDB 235 2e-62 2WQN-A nrPDB 235 2e-62 3C51-A nrPDB 235 3e-62 5ZTN-A nrPDB 234 4e-62 3FI2-A nrPDB 234 4e-62 4UYA-A nrPDB 234 4e-62 5VO2-A nrPDB 234 4e-62 4BGQ-A nrPDB 234 4e-62 3MIA-A nrPDB 234 5e-62 5G6V-A nrPDB 232 1e-61 4GS6-A nrPDB 232 2e-61 5SYS-A nrPDB 232 2e-61 4NST-A nrPDB 232 3e-61 4UY9-A nrPDB 231 3e-61 4E7W-A nrPDB 231 4e-61 4O2Z-A nrPDB 231 4e-61 5EFQ-A nrPDB 231 5e-61 4X7Q-B nrPDB 230 5e-61 3DTC-A nrPDB 230 6e-61 5H2U-A nrPDB 230 6e-61 5TUR-A nrPDB 230 1e-60 4RC3-A nrPDB 229 2e-60 3BGP-A nrPDB 229 2e-60 3M42-A nrPDB 228 2e-60 4OTD-A nrPDB 228 2e-60 4P5Q-A nrPDB 228 3e-60 5X5O-A nrPDB 228 4e-60 2W96-B nrPDB 227 5e-60 4AN9-A nrPDB 227 6e-60 4Y93-A nrPDB 227 7e-60 6DBM-A nrPDB 226 1e-59 2DQ7-X nrPDB 225 2e-59 5MJB-A nrPDB 225 2e-59 4YHJ-A nrPDB 225 2e-59 1JPA-A nrPDB 225 2e-59 1FVR-A nrPDB 225 3e-59 3QGY-A nrPDB 225 3e-59 4U41-A nrPDB 225 3e-59 5L6P-A nrPDB 224 4e-59 3DKO-A nrPDB 224 4e-59 2I6L-A nrPDB 224 4e-59 1U5R-A nrPDB 224 4e-59 2HK5-A nrPDB 224 4e-59 2Y6O-A nrPDB 223 7e-59 2XNP-A nrPDB 223 9e-59 4CRS-A nrPDB 223 9e-59 2GCD-A nrPDB 223 1e-58 3VN9-A nrPDB 223 1e-58 4XI2-A nrPDB 223 1e-58 2R2P-A nrPDB 222 2e-58 4E93-A nrPDB 222 2e-58 4OLI-A nrPDB 222 2e-58 3ALO-A nrPDB 221 3e-58 5O0Y-A nrPDB 221 3e-58 3A4O-X nrPDB 221 4e-58 1AD5-A nrPDB 221 4e-58 3FME-A nrPDB 220 5e-58 3DLS-A nrPDB 220 6e-58 4KIK-B nrPDB 220 7e-58 2VWV-A nrPDB 220 8e-58 2PL0-A nrPDB 219 1e-57 1K9A-A nrPDB 219 1e-57 2WTK-C nrPDB 219 2e-57 6E4F-A nrPDB 218 2e-57 3E3P-A nrPDB 218 3e-57 3V5Q-A nrPDB 218 3e-57 5KKR-C nrPDB 218 3e-57 3SXS-A nrPDB 217 5e-57 4AT3-A nrPDB 217 5e-57 4XCU-A nrPDB 217 7e-57 5TQX-A nrPDB 216 1e-56 5O2B-A nrPDB 216 1e-56 1BYG-A nrPDB 216 1e-56 3N9X-A nrPDB 216 1e-56 4E20-A nrPDB 216 1e-56 3EQC-A nrPDB 215 2e-56 3TT0-A nrPDB 215 2e-56 4PWN-A nrPDB 215 2e-56 3PG1-A nrPDB 215 2e-56 6O6Q-A nrPDB 215 2e-56 5O2C-A nrPDB 215 2e-56 3ORP-A nrPDB 215 3e-56 6FEX-A nrPDB 215 3e-56 3KUL-B nrPDB 215 3e-56 3RP9-A nrPDB 215 3e-56 5KMM-A nrPDB 214 4e-56 4HZS-A nrPDB 214 4e-56 5A46-A nrPDB 214 4e-56 3EB0-A nrPDB 214 6e-56 6BSD-A nrPDB 213 1e-55 4PDO-A nrPDB 213 1e-55 3GQL-A nrPDB 213 1e-55 4EQM-A nrPDB 213 1e-55 6GVJ-A nrPDB 213 1e-55 2PSQ-A nrPDB 210 6e-55 3NIE-A nrPDB 210 8e-55 5AMN-A nrPDB 210 8e-55 1LUF-A nrPDB 210 1e-54 1ZXE-A nrPDB 210 1e-54 2W1I-A nrPDB 210 1e-54 6DBN-A nrPDB 209 2e-54 5HVK-A nrPDB 209 2e-54 1S9I-A nrPDB 208 3e-54 1U54-B nrPDB 208 4e-54 5X8I-B nrPDB 208 4e-54 3IO7-A nrPDB 207 5e-54 3HMP-A nrPDB 207 5e-54 4K33-A nrPDB 207 7e-54 4IDT-A nrPDB 207 7e-54 6FER-A nrPDB 207 9e-54 5EG3-A nrPDB 207 1e-53 4HVI-A nrPDB 205 2e-53 2ZMD-A nrPDB 205 2e-53 5AP3-A nrPDB 205 2e-53 4F0G-A nrPDB 205 2e-53 5TE0-A nrPDB 205 2e-53 5HI2-A nrPDB 205 3e-53 3ZBF-A nrPDB 205 3e-53 3BBT-B nrPDB 204 4e-53 4Y83-A nrPDB 204 5e-53 5B2L-A nrPDB 204 5e-53 3OMV-A nrPDB 202 2e-52 5HIE-A nrPDB 202 3e-52 5U6B-A nrPDB 201 4e-52 3LZB-A nrPDB 201 4e-52 4C59-A nrPDB 200 5e-52 2WO6-A nrPDB 200 5e-52 4MD7-E nrPDB 200 6e-52 4TPT-A nrPDB 200 8e-52 3PLS-A nrPDB 199 1e-51 5GNK-A nrPDB 199 1e-51 3QUP-A nrPDB 199 2e-51 6HMD-A nrPDB 199 2e-51 4G3E-A nrPDB 198 2e-51 5HLW-A nrPDB 198 3e-51 3C1X-A nrPDB 198 3e-51 1U59-A nrPDB 198 3e-51 3PP0-A nrPDB 198 4e-51 2OZO-A nrPDB 197 1e-50 2WTK-B nrPDB 196 1e-50 6EII-A nrPDB 195 3e-50 3RAW-A nrPDB 195 3e-50 5IKW-A nrPDB 195 3e-50 2A1A-B nrPDB 194 5e-50 5WNO-A nrPDB 194 5e-50 2BUJ-A nrPDB 194 6e-50 4JLC-A nrPDB 193 8e-50 4LRM-A nrPDB 193 8e-50 4CRL-A nrPDB 193 9e-50 3Q4U-A nrPDB 193 9e-50 2PVN-A nrPDB 193 1e-49 5WNL-A nrPDB 193 1e-49 4EUU-A nrPDB 192 2e-49 4OW8-A nrPDB 192 2e-49 6B2Q-A nrPDB 192 2e-49 4X3F-A nrPDB 192 2e-49 5UIU-A nrPDB 192 3e-49 3MY0-A nrPDB 191 4e-49 4NEU-A nrPDB 191 4e-49 4EUT-A nrPDB 191 4e-49 5UNP-A nrPDB 191 4e-49 5XVU-A nrPDB 191 5e-49 3UIU-A nrPDB 189 1e-48 5TOS-A nrPDB 189 1e-48 4M7I-A nrPDB 189 1e-48 4YFF-A nrPDB 189 2e-48 6O8B-A nrPDB 188 2e-48 6NT9-A nrPDB 188 3e-48 3MDY-A nrPDB 188 4e-48 6CTH-A nrPDB 187 7e-48 3AOX-A nrPDB 186 1e-47 5VD3-A nrPDB 186 1e-47 2RIO-A nrPDB 184 4e-47 4FL3-A nrPDB 184 4e-47 3ZZW-A nrPDB 182 2e-46 5VC6-A nrPDB 181 4e-46 5C26-A nrPDB 181 5e-46 5LPZ-A nrPDB 180 9e-46 1PY5-A nrPDB 180 9e-46 6J5U-C nrPDB 180 1e-45 5LPV-A nrPDB 180 1e-45 5AR8-A nrPDB 179 2e-45 5CEK-A nrPDB 178 3e-45 6DC0-A nrPDB 178 4e-45 6HV0-A nrPDB 177 6e-45 4PL5-B nrPDB 176 9e-45 2X7G-A nrPDB 176 1e-44 3LMG-A nrPDB 176 1e-44 4IAN-A nrPDB 176 2e-44 4WUA-A nrPDB 175 3e-44 5XD6-A nrPDB 174 5e-44 3LLT-A nrPDB 173 9e-44 5L2Q-C nrPDB 173 1e-43 2JD5-A nrPDB 172 2e-43 2Y4I-B nrPDB 170 6e-43 3UIM-A nrPDB 170 7e-43 4LFI-A nrPDB 169 1e-42 2PMN-X nrPDB 168 2e-42 2H34-A nrPDB 168 3e-42 4LQP-A nrPDB 167 5e-42 4M66-A nrPDB 166 1e-41 3REP-A nrPDB 165 3e-41 3SOC-A nrPDB 165 3e-41 5VDK-A nrPDB 165 4e-41 5E8V-A nrPDB 165 4e-41 5FQD-C nrPDB 162 2e-40 3SV0-A nrPDB 162 3e-40 4TN6-A nrPDB 161 3e-40 4F9B-A nrPDB 158 4e-39 2QLU-A nrPDB 157 5e-39 4MWI-A nrPDB 157 6e-39 2CHL-A nrPDB 157 8e-39 2QKW-B nrPDB 156 1e-38 2CMW-A nrPDB 155 2e-38 4NT4-A nrPDB 154 7e-38 2C47-A nrPDB 153 1e-37 4BTK-A nrPDB 153 2e-37 4NFN-A nrPDB 152 3e-37 5X1R-A nrPDB 149 2e-36 1CSN-A nrPDB 147 7e-36 3QD2-B nrPDB 145 3e-35 5J0A-A nrPDB 142 2e-34 5M07-A nrPDB 142 3e-34 4XHL-A nrPDB 137 8e-33 2PZI-A nrPDB 132 3e-31 4Y12-A nrPDB 132 3e-31 5OAT-A nrPDB 112 2e-25 5CLR-A nrPDB 88 6e-18 Sequences not found previously or not previously below threshold: 4EBW-A nrPDB 229 1e-60 2J0K-A nrPDB 225 3e-59 6GQK-A nrPDB 209 1e-54 4H1J-A nrPDB 209 2e-54 4XUF-A nrPDB 206 1e-53 2OGV-A nrPDB 206 1e-53 5X02-A nrPDB 205 2e-53 3BEA-A nrPDB 205 3e-53 5FM2-A nrPDB 205 3e-53 3KRL-A nrPDB 203 6e-53 4XLV-A nrPDB 203 1e-52 4R7H-A nrPDB 203 1e-52 3CJF-A nrPDB 199 2e-51 3G0E-A nrPDB 198 2e-51 5GRN-A nrPDB 197 8e-51 6FYV-A nrPDB 196 1e-50 3I81-A nrPDB 190 8e-49 5U6C-A nrPDB 182 2e-46 6BFN-A nrPDB 152 2e-37 5X18-A nrPDB 150 7e-37 4M69-B nrPDB 148 4e-36 4BTF-A nrPDB 147 8e-36 3G2F-A nrPDB 145 3e-35 3HNG-A nrPDB 139 2e-33 4XHH-A nrPDB 138 4e-33 3VHK-A nrPDB 137 6e-33 4RT7-A nrPDB 132 3e-31 4L00-A nrPDB 131 5e-31 5USZ-A nrPDB 129 2e-30 5C01-A nrPDB 119 2e-27 4WOV-A nrPDB 118 3e-27 5UV4-A nrPDB 113 1e-25 6EQI-C nrPDB 108 4e-24 4I94-A nrPDB 107 6e-24 4L68-A nrPDB 105 3e-23 6J6I-B nrPDB 100 9e-22 4JRN-A nrPDB 99 1e-21 5UU1-A nrPDB 96 3e-20 4IX6-A nrPDB 92 3e-19 2RSV-A nrPDB 91 6e-19 2LAV-A nrPDB 90 1e-18 4O1O-A nrPDB 82 3e-16 6G4J-A nrPDB 82 4e-16 6EAS-A nrPDB 78 4e-15 5DMZ-A nrPDB 77 1e-14 6EWX-A nrPDB 75 3e-14 4OAU-C nrPDB 74 1e-13 4CI6-B nrPDB 72 5e-13 5VE6-A nrPDB 70 2e-12 6BHC-A nrPDB 69 3e-12 2JII-A nrPDB 67 1e-11 6M7Z-A nrPDB 62 3e-10 5GZ9-A nrPDB 57 1e-08 5GZA-A nrPDB 56 2e-08 4CYJ-A nrPDB 55 5e-08 4AZW-A nrPDB 53 3e-07 6G38-A nrPDB 53 3e-07 4AZV-A nrPDB 52 4e-07 4BWP-A nrPDB 50 2e-06 4CZY-B nrPDB 50 2e-06 3ENH-A nrPDB 47 1e-05 2W1Z-A nrPDB 45 4e-05 3BYV-A nrPDB 45 4e-05 3DZO-A nrPDB 43 2e-04 4WWA-A nrPDB 41 7e-04 1TQM-A nrPDB 37 0.013 3Q60-A nrPDB 36 0.031 5YK0-A nrPDB 34 0.067 4BVU-A nrPDB 34 0.090 6G5I-z nrPDB 34 0.12 4OTP-A nrPDB 34 0.13 6EF6-A nrPDB 33 0.33 6G18-v nrPDB 32 0.37 6FDN-A nrPDB 31 0.70 4H05-A nrPDB 31 0.85 4GYG-A nrPDB 29 2.4 6QM4-A nrPDB 29 3.1 >3UC3-A nrPDB Length = 361 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 359/361 (99%), Positives = 359/361 (99%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG ID Sbjct: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID 60 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF Sbjct: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT Sbjct: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE Sbjct: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 Query: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA 360 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA Sbjct: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYA 360 Query: 361 L 361 L Sbjct: 361 L 361 >3ZUT-A nrPDB Length = 362 Score = 470 bits (1209), Expect = e-133, Method: Composition-based stats. Identities = 287/363 (79%), Positives = 327/363 (90%), Gaps = 3/363 (0%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDR P +GP+D+PIMHDSDRY+ VKDIGSGNFGVARLMRDK + ELVAVKYIERG+KID Sbjct: 1 MDR-PAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID 59 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQL+SGVSYCH+MQ+CHRDLKLENTLLDGSPAPRLKIC FGYSKSSVLHSQPKSTVGT Sbjct: 120 FFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGT 179 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 Query: 301 QPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDM--DDFDSESEIDIDSSGEIV 358 QP QS++ IMQII+EAT+P + L+ ++T +LD+DDDM D ++DIDSSGEIV Sbjct: 300 QPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIV 359 Query: 359 YAL 361 YA+ Sbjct: 360 YAM 362 >5WAX-A nrPDB Length = 310 Score = 445 bits (1144), Expect = e-125, Method: Composition-based stats. Identities = 260/309 (84%), Positives = 291/309 (94%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH 70 +DMPIMHD DRY+ V+DIGSGNFGVARLMR++ +LVAVKYIERG+KIDENVQREIINH Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINH 61 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 RSLRHPNI+RFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARFFFQQL+SGVS Sbjct: 62 RSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 YCHSMQ+CHRDLKLENTLLDGS APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 ++EYDGK+ADVWSCGVTLYVMLVGAYPFEDP+EP+++RKTIQRIL V+YSIPD + ISPE Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 C LISRIFVA+PATRI+IPEI+ H WFLKNLPADLM++S Q++EPEQPMQS+D IM Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDEIM 301 Query: 311 QIISEATIP 319 QI++EATIP Sbjct: 302 QILAEATIP 310 >3UDB-A nrPDB Length = 317 Score = 440 bits (1132), Expect = e-124, Method: Composition-based stats. Identities = 261/318 (82%), Positives = 292/318 (91%), Gaps = 1/318 (0%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 MDR P GP+D+PIMHDSDRY+ VKDIG+GNFGVARLMRDK ELVAVKYIERG+KID Sbjct: 1 MDR-PAVAGPMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID 59 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ENV+REIINHRSLRHPNIVRFKEVILTPTHLAI+MEYASGGEL+ERICNAGRFSEDEARF Sbjct: 60 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 FFQQL+SGVSY H+MQ+ HRDLKLENTLLDGSPAPRLKI DFGYSK+SVLHSQPKS VGT Sbjct: 120 FFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGT 179 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 PAYIAPEVLL++EYDGK+ADVWSCGVTLYVMLVGAYPFEDPEEP+++RKTI RIL+V+Y+ Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYA 239 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 IPD + ISPEC HLISRIFVADPA RISIPEI+ H WFLKNLPADLMN++ +QF E + Sbjct: 240 IPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESD 299 Query: 301 QPMQSLDTIMQIISEATI 318 QP QS++ IMQII+EAT+ Sbjct: 300 QPGQSIEEIMQIIAEATV 317 >4REW-A nrPDB Length = 540 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 114/334 (34%), Positives = 169/334 (50%), Gaps = 19/334 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRHP 76 Y +G G FG ++ + +LT VAVK + R ++REI N + RHP Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +I++ +VI TP+ + ++MEY SGGEL++ IC GR E E+R FQQ+LSGV YCH Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 127 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 184 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+WS GV LY +L G PF+D P ++K I + P ++P L+ Sbjct: 185 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQY--LNPSVISLLK 238 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEA 316 + DP R SI +I+ H WF ++LP L E + S ++ ++ + + E Sbjct: 239 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEE 298 Query: 317 TIPAVRNRCLDDF-------MTDNLDLDDDMDDF 343 + + NR D + DN + ++ DF Sbjct: 299 VLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 332 >4CFH-A nrPDB Length = 493 Score = 354 bits (909), Expect = 3e-98, Method: Composition-based stats. Identities = 117/351 (33%), Positives = 174/351 (49%), Gaps = 23/351 (6%) Query: 8 TGPLDMPIMHDS----DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-- 61 GP+ HD Y +G G FG ++ + +LT VAVK + R Sbjct: 17 QGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDV 76 Query: 62 --NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR 119 ++REI N + RHP+I++ +VI TP+ + ++MEY SGGEL++ IC GR E E+R Sbjct: 77 VGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR 136 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 179 FQQ+LSGV YCH + HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCG 194 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 +P Y APEV+ + Y G D+WS GV LY +L G PF+D P ++K I + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----F 250 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 P ++P L+ + DP R +I +I+ H WF ++LP L E + S Sbjct: 251 YTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 308 Query: 300 EQPMQSLDTIMQIISEATIPAVRNRCLDDF-------MTDNLDLDDDMDDF 343 ++ ++ + + E + + NR D + DN + ++ DF Sbjct: 309 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 359 >4RED-A nrPDB Length = 351 Score = 349 bits (897), Expect = 8e-97, Method: Composition-based stats. Identities = 114/334 (34%), Positives = 169/334 (50%), Gaps = 19/334 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRHP 76 Y +G G FG ++ + +LT VAVK + R ++REI N + RHP Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +I++ +VI TP+ + ++MEY SGGEL++ IC GR E E+R FQQ+LSGV YCH Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 135 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+WS GV LY +L G PF+D P ++K I + P ++P L+ Sbjct: 193 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI----FYTPQY--LNPSVISLLK 246 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEA 316 + DP R SI +I+ H WF ++LP L E + S ++ ++ + + E Sbjct: 247 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEE 306 Query: 317 TIPAVRNRCLDDF-------MTDNLDLDDDMDDF 343 + + NR D + DN + ++ DF Sbjct: 307 VLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDF 340 >4CFF-A nrPDB Length = 571 Score = 337 bits (864), Expect = 5e-93, Method: Composition-based stats. Identities = 115/351 (32%), Positives = 171/351 (48%), Gaps = 23/351 (6%) Query: 8 TGPLDMPIMHDS----DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-- 61 GP+ HD Y +G G FG ++ +LT VAVK + R Sbjct: 17 QGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV 76 Query: 62 --NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR 119 ++REI N + RHP+I++ +VI TPT ++MEY SGGEL++ IC GR E EAR Sbjct: 77 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 136 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG 179 FQQ+LS V YCH + HRDLK EN LLD KI DFG S +++ G Sbjct: 137 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCG 194 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 +P Y APEV+ + Y G D+WSCGV LY +L G PF+D P ++K I + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVF 250 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 IP+ + S L+ + DP R +I +I+ H WF ++LP+ L E + Sbjct: 251 YIPEYLNRS--VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID 308 Query: 300 EQPMQSLDTIMQIISEATIPAVRNRCLDD-------FMTDNLDLDDDMDDF 343 ++ ++ + + + ++ + D + DN + + +F Sbjct: 309 DEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEF 359 >5EZV-A nrPDB Length = 560 Score = 331 bits (849), Expect = 3e-91, Method: Composition-based stats. Identities = 111/334 (33%), Positives = 166/334 (49%), Gaps = 19/334 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRHP 76 Y +G G FG ++ +LT VAVK + R ++REI N + RHP Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +I++ +VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH Sbjct: 89 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 148 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y G Sbjct: 149 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 206 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+WSCGV LY +L G PF+D P ++K I + IP+ + S L+ Sbjct: 207 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLM 260 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEA 316 + DP R +I +I+ H WF ++LP+ L E + ++ ++ + + Sbjct: 261 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESE 320 Query: 317 TIPAVRNRCLDD-------FMTDNLDLDDDMDDF 343 + ++ + D + DN + + +F Sbjct: 321 VMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEF 354 >3HZT-A nrPDB Length = 467 Score = 330 bits (847), Expect = 5e-91, Method: Composition-based stats. Identities = 112/338 (33%), Positives = 170/338 (50%), Gaps = 23/338 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLR 74 SDRY VK +GSG +G L +DKLT A+K I++ + + E+ + L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNI++ E + ++ME GGEL++ I +FSE +A +Q+LSG +Y H Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 135 MQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 I HRDLK EN LL+ +KI DFG S + + K +GT YIAPEVL R++ Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RKK 181 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 YD K DVWSCGV LY++L G PF + ++ ++R+ K+S PD ++S E Sbjct: 182 YDEK-CDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSFDPPDWTQVSDEA 236 Query: 252 CHLISRIFVADPATRISIPEIKTHSW---FLKNLPADLMNESNTGS-----QFQEPEQPM 303 L+ + +P+ RIS E H W F D+ + TG+ +FQ ++ Sbjct: 237 KQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQSSQKLA 296 Query: 304 QSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 Q+ ++ + S+ T F + + D +D Sbjct: 297 QA--AMLFMGSKLTTLEETKELTQIFRQLDNNGDGQLD 332 >5JN2-A nrPDB Length = 525 Score = 324 bits (832), Expect = 3e-89, Method: Composition-based stats. Identities = 113/363 (31%), Positives = 173/363 (47%), Gaps = 33/363 (9%) Query: 4 APVTTGPLD-------MPIMHD----SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKY 52 A + GP D M + H SDRY + +G G+FG L +DK+T + AVK Sbjct: 40 AGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV 99 Query: 53 IERGD----KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC 108 I + E++ RE+ + L HPNI++ E + ++ E +GGEL++ I Sbjct: 100 ISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEII 159 Query: 109 NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKS 167 + RFSE +A +Q+LSG++Y H +I HRDLK EN LL+ S ++I DFG S Sbjct: 160 SRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTH 219 Query: 168 SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 + K +GT YIAPEVL YD K DVWS GV LY++L G PF E Sbjct: 220 FEASKKMKDKIGTAYYIAPEVLHG-TYDEK-CDVWSTGVILYILLSGCPPFNGANEYD-- 275 Query: 228 RKTIQRILSVKYSI--PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL----KN 281 ++++ KY+ P ++S LI ++ P+ RIS + H W + Sbjct: 276 --ILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 333 Query: 282 LPADLMNESNT---GSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDD 338 + D+ + N QFQ ++ Q+ ++ + S+ T F + + D Sbjct: 334 ISVDVPSLDNAILNIRQFQGTQKLAQA--ALLYMGSKLTSQDETKELTAIFHKMDKNGDG 391 Query: 339 DMD 341 +D Sbjct: 392 QLD 394 >3LIJ-A nrPDB Length = 494 Score = 319 bits (817), Expect = 1e-87, Method: Composition-based stats. Identities = 104/339 (30%), Positives = 163/339 (48%), Gaps = 22/339 (6%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSL 73 H S+ Y VK +GSG +G L RDK+T A+K I + + + E+ + L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 HPNI++ + + ++ME GGEL++ I + +F+E +A +Q+LSGV+Y H Sbjct: 94 DHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 134 SMQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 I HRDLK EN LL+ +KI DFG S + K +GT YIAPEVL R+ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL-RK 212 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPE 250 +YD K DVWS GV L+++L G PF + ++ ++++ KY+ P+ +S Sbjct: 213 KYDEK-CDVWSIGVILFILLAGYPPFGG----QTDQEILRKVEKGKYTFDSPEWKNVSEG 267 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLP--------ADLMNESNTGSQFQEPEQP 302 LI ++ D RIS + H W + L N +FQ ++ Sbjct: 268 AKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANAIENMRKFQNSQKL 327 Query: 303 MQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 Q+ ++ + S+ T D F + + D +D Sbjct: 328 AQA--ALLYMASKLTSQEETKELTDIFRHIDKNGDGQLD 364 >3DXN-A nrPDB Length = 287 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 102/281 (36%), Positives = 151/281 (53%), Gaps = 13/281 (4%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN---- 62 ++G ++ SDRY VK +GSG +G L +DKLT A+K I++ + Sbjct: 8 SSGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGA 67 Query: 63 VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFF 122 + E+ + L HPNI++ E + ++ME GGEL++ I +FSE +A Sbjct: 68 LLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIM 127 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTP 181 +Q+LSG +Y H I HRDLK EN LL+ +KI DFG S + + K +GT Sbjct: 128 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTA 187 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 YIAPEVL R++YD K DVWSCGV LY++L G PF + ++ ++R+ K+S Sbjct: 188 YYIAPEVL-RKKYDEK-CDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSF 241 Query: 242 --PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 PD ++S E L+ + +P+ RIS E H W +K Sbjct: 242 DPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >3NCG-A nrPDB Length = 486 Score = 312 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 105/337 (31%), Positives = 171/337 (50%), Gaps = 22/337 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN---VQREIINHRSLRH 75 ++RY+ V +G G+FG +D++T++ AVK I + +++ + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI++ E++ + I+ E +GGEL++ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 136 QICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEVL Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECC 252 D K DVWS GV LY++L G PF E ++R+ + KY+ P IS + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNEYD----ILKRVETGKYAFDLPQWRTISDDAK 254 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK-----NLPADLMNESNTGS---QFQEPEQPMQ 304 LI ++ P+ RI+ + H W K +DL + + + QFQ ++ Q Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQ 314 Query: 305 SLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 + ++ + S+ T + + F + + D +D Sbjct: 315 A--ALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLD 349 >3Q5I-A nrPDB Length = 504 Score = 311 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 103/349 (29%), Positives = 164/349 (46%), Gaps = 36/349 (10%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG--------------DKIDENVQ 64 + Y V+ +GSG +G L ++K A+K I++ +K E + Sbjct: 35 GESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 EI +SL HPNI++ +V + ++ E+ GGEL+E+I N +F E +A +Q Sbjct: 95 NEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQ 154 Query: 125 LLSGVSYCHSMQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 +LSG+ Y H I HRD+K EN LL + + +KI DFG S + + +GT Y Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--SI 241 IAPEVL ++ + DVWSCGV +Y++L G PF + + I+++ KY Sbjct: 215 IAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQND----QDIIKKVEKGKYYFDF 268 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGS------- 294 D IS E LI + D R + E W K A+ +N+S+ + Sbjct: 269 NDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK--YANNINKSDQKTLCGALSN 326 Query: 295 --QFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 +F+ ++ Q+ I+ I S+ T R D F + + D +D Sbjct: 327 MRKFEGSQKLAQA--AILFIGSKLTTLEERKELTDIFKKLDKNGDGQLD 373 >5ES1-A nrPDB Length = 328 Score = 310 bits (794), Expect = 6e-85, Method: Composition-based stats. Identities = 103/284 (36%), Positives = 154/284 (54%), Gaps = 17/284 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRHPN 77 Y ++ IG GNF +L R LT VA+K I++ + + RE+ + L HPN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ EVI T L ++MEYAS GE+++ + + GR E EAR F+Q++S V YCH I Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 135 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD +KI DFG+S L S+ + G+P Y APE+ ++YDG Sbjct: 136 VHRDLKAENLLLDAE--ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 D+WS GV LY ++ G+ PF+ ++ +R+L KY +P +S +C ++ R Sbjct: 194 EVDIWSLGVILYTLVSGSLPFDGHN----LKELRERVLRGKYRVP--FYMSTDCESILRR 247 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 V +PA R ++ +I W ++ E + EPE+ Sbjct: 248 FLVLNPAKRCTLEQIMKDKWI------NIGYEGEELKPYTEPEE 285 >2QNJ-A nrPDB Length = 328 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 108/283 (38%), Positives = 157/283 (55%), Gaps = 17/283 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPN 77 Y +K IG GNF +L R LT VA+K I++ ++Q RE+ + L HPN Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ EVI T L +IMEYASGGE+++ + GR E EAR F+Q++S V YCH +I Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 132 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD +KI DFG+S + + + G+P Y APE+ ++YDG Sbjct: 133 VHRDLKAENLLLDADM--NIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 190 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWS GV LY ++ G+ PF+ ++ ++ +R+L KY IP +S +C +L+ R Sbjct: 191 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIP--FYMSTDCENLLKR 244 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 V +P R ++ +I W + +E + F EPE Sbjct: 245 FLVLNPIKRGTLEQIMKDRWI------NAGHEEDELKPFVEPE 281 >4MVF-A nrPDB Length = 506 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 96/366 (26%), Positives = 162/366 (44%), Gaps = 31/366 (8%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPN 77 D+Y + +G G +G DK+T +L A+K ++ + +EI + L HPN Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPN 115 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ E ++ +IME SG EL++ I G F+E A +Q+ S + Y HS+ I Sbjct: 116 IVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 138 CHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRDLK EN L + LKI DFG SK+ + GTP Y+AP+VL + Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK--YD 233 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHL 254 K D+WS GV +Y +L G PF + + ++++ ++ D IS + +L Sbjct: 234 KKCDIWSSGVIMYTLLCGYPPFYGDTD----NEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNL--PADLMNESNTGSQFQEPEQPMQSLDTIMQI 312 I+++ +P R +I E H W + + S + ++ + + I Sbjct: 290 ITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKNLKNFKKENELKKIALTI 349 Query: 313 ISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSES-------------------EIDIDS 353 I++ N + F+ ++D + + +ID ++ Sbjct: 350 IAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLKKIGYQKIPPDIHQVLRDIDSNA 409 Query: 354 SGEIVY 359 SG+I Y Sbjct: 410 SGQIHY 415 >5FG8-A nrPDB Length = 285 Score = 307 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 91/268 (33%), Positives = 136/268 (50%), Gaps = 8/268 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRH 75 SD YD +++G G F + + K T A K I + Q RE R L H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I + ++ + +GGEL+E I +SE +A QQ+L V++CH Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 + HRDLK EN LL +K+ DFG + Q GTP Y++PEVL ++ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y GK D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE + Sbjct: 193 Y-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI--KAGAYDYPSPEWDTVTPEAKN 249 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKN 281 LI+++ +P RI+ E H W + Sbjct: 250 LINQMLTVNPNKRITAAEALKHPWICQR 277 >3MA6-A nrPDB Length = 298 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 100/283 (35%), Positives = 145/283 (51%), Gaps = 18/283 (6%) Query: 8 TGPLDMPIMHD----SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----KI 59 GP M + H SDRY + +G G+FG L +DK+T + AVK I + Sbjct: 17 QGPG-MFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD 75 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR 119 E++ RE+ + L HPNI++ E + ++ E +GGEL++ I + RFSE +A Sbjct: 76 KESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAA 135 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTV 178 +Q+LSG++Y H +I HRDLK EN LL+ S ++I DFG S + K + Sbjct: 136 RIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKI 195 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GT YIAPEVL YD K DVWS GV LY++L G PF E ++++ K Sbjct: 196 GTAYYIAPEVLHG-TYDEK-CDVWSTGVILYILLSGCPPFNGANEYD----ILKKVEKGK 249 Query: 239 YSI--PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 Y+ P ++S LI ++ P+ RIS + H W Sbjct: 250 YTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 >2VN9-A nrPDB Length = 301 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 94/280 (33%), Positives = 145/280 (51%), Gaps = 9/280 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 +D Y +++G G F V R T + A K I + + + ++RE R L+H Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I ++ + +GGEL+E I +SE +A QQ+L V++CH Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 136 QICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 I HRDLK EN LL S +K+ DFG + Q GTP Y++PEVL + Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y GK D+W+CGV LY++LVG PF D ++ R Y++ + + + P+ ++PE Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 239 Query: 254 LISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNESNT 292 LI+++ +PA RI+ E H W ++ A +M+ T Sbjct: 240 LINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQET 279 >3DFA-A nrPDB Length = 286 Score = 307 bits (786), Expect = 6e-84, Method: Composition-based stats. Identities = 94/268 (35%), Positives = 144/268 (53%), Gaps = 12/268 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN---VQREIINHRSLRH 75 ++RY+ V +G G+FG +D++T++ AVK I + +++ + RE+ + L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI++ E++ + I+ E +GGEL++ I RFSE +A +Q+ SG++Y H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 136 QICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRDLK EN LL+ +KI DFG S +++ K +GT YIAPEVL Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECC 252 D K DVWS GV LY++L G PF E ++R+ + KY+ P IS + Sbjct: 200 DEK-CDVWSAGVILYILLSGTPPFYGKNEYD----ILKRVETGKYAFDLPQWRTISDDAK 254 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK 280 LI ++ P+ RI+ + H W K Sbjct: 255 DLIRKMLTFHPSLRITATQCLEHPWIQK 282 >5KZ7-A nrPDB Length = 346 Score = 306 bits (785), Expect = 8e-84, Method: Composition-based stats. Identities = 104/282 (36%), Positives = 158/282 (56%), Gaps = 17/282 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRHPN 77 Y +K IG GNF +L R LT + VAVK I++ ++Q RE+ + L HPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 153 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD +KI DFG+S ++ + G+P Y APE+ ++YDG Sbjct: 154 VHRDLKAENLLLDADM--NIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 211 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWS GV LY ++ G+ PF+ ++ ++ +R+L KY IP +S +C +L+ + Sbjct: 212 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIP--FYMSTDCENLLKK 265 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 + +P+ R ++ +I W ++ +E + + EP Sbjct: 266 FLILNPSKRGTLEQIMKDRWM------NVGHEDDELKPYVEP 301 >5IG1-A nrPDB Length = 344 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 95/317 (29%), Positives = 147/317 (46%), Gaps = 20/317 (6%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---NVQREIINHRS 72 ++D D D IG G F +K T E+ AVK I ++REI S Sbjct: 13 LYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSS 72 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 L+H +IV + +H ++ EY SGGEL++ I ++E +A Q+LS + +C Sbjct: 73 LQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHC 132 Query: 133 HSMQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 HS I HRDLK EN LL P +KI DFG + GTP Y++PEV+ R Sbjct: 133 HSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRR 192 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISP 249 YD DVW+CGV LY++LVG PF + D++K +I + +Y P+ ++ Sbjct: 193 VPYDT-AVDVWACGVILYILLVGYPPFWE----EDHQKLYAQIKNCQYDFPSPEWDSVTT 247 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES---------NTGSQFQEPE 300 LI + +P R ++ E+ H W + ++ N + + Sbjct: 248 AAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSVHRQATLEELKKFNARRKLKGGV 307 Query: 301 QPMQSLDTIMQIISEAT 317 + + +M+ + EAT Sbjct: 308 NAVIGVSKMMRTMQEAT 324 >4CZT-A nrPDB Length = 464 Score = 304 bits (779), Expect = 3e-83, Method: Composition-based stats. Identities = 109/311 (35%), Positives = 167/311 (53%), Gaps = 24/311 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRHP 76 +Y+ + +G G F + R+ + VA+K I++ + ++REI + ++HP Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N++R EV+ + T + ++E+ +GGEL+++I + GR EDEAR +FQQL++ V YCHS Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 131 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYS---KSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 + HRDLK EN LLD + A LK+ DFG S + +T GTP Y+APEV+ + Sbjct: 132 VYHRDLKPENLLLDANGA--LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 YDG AD+WSCGV L+V++ G PFED Y+K I +++ P S Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKK----IFKAEFTCPPW--FSASAKK 243 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQII 313 LI RI +PATRI+ E+ + WF K A +F+ + + +D I Sbjct: 244 LIKRILDPNPATRITFAEVIENEWFKKGYKAP---------KFENADVSLDDVDAIFDDS 294 Query: 314 SEATIPAVRNR 324 E+ V R Sbjct: 295 GESKNLVVERR 305 >2BDW-A nrPDB Length = 362 Score = 304 bits (779), Expect = 4e-83, Method: Composition-based stats. Identities = 100/341 (29%), Positives = 152/341 (44%), Gaps = 11/341 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRH 75 SD YD +++G G F V R K T A K I + Q RE R L+H Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 87 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I + ++ + +GGEL+E I +SE +A QQ+L ++YCHS Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HR+LK EN LL +K+ DFG + GTP Y++PEVL + Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 K D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE L Sbjct: 208 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 264 Query: 255 ISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNTGSQFQEPEQPMQSLDTIMQII 313 I + +P RI+ + W + A ++ +T ++ + I+ + Sbjct: 265 IDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKGAILTTM 324 Query: 314 SEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSS 354 + R L + SES ID + Sbjct: 325 IATRNLSNLGRNL---LNKKEQGPPSTIKESSESSQTIDDN 362 >4YZB-A nrPDB Length = 491 Score = 304 bits (779), Expect = 4e-83, Method: Composition-based stats. Identities = 102/337 (30%), Positives = 161/337 (47%), Gaps = 22/337 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLR 74 SDRY + +G G+FG L +DK+T + AVK I + + + +E+ + L Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HPNI++ E + ++ E +GGEL++ I + RFSE +A +Q+LSG++Y H Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 148 Query: 135 MQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 +I HRDLK EN LL + ++I DFG S + K +GT YIAPEVL Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG-T 207 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 YD K DVWS GV LY++L G PF E ++++ K++ P ++S Sbjct: 208 YDEK-CDVWSTGVILYILLSGCPPFNGANE----FDILKKVEKGKFTFDLPQWKKVSEPA 262 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNTGS------QFQEPEQPMQ 304 LI ++ P RIS + H W + D ++ + S QFQ ++ Sbjct: 263 KDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKL-- 320 Query: 305 SLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 + ++ + S+ T F + + D +D Sbjct: 321 AAAALLYMGSKLTTNEETVELNKIFQRMDKNGDGQLD 357 >3H4J-B nrPDB Length = 336 Score = 303 bits (777), Expect = 6e-83, Method: Composition-based stats. Identities = 113/279 (40%), Positives = 159/279 (56%), Gaps = 13/279 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE----RGDKIDENVQREIINHRSLRHPN 77 Y + +G G+FG +L T++ VA+K+I + + V+REI + LRHP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I++ +VI TPT + +++EYA GGEL++ I R +EDE R FFQQ++ + YCH +I Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLD + +KI DFG S + K++ G+P Y APEV+ + Y G Sbjct: 130 VHRDLKPENLLLDDNL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWSCG+ LYVMLVG PF+D P +++ S Y +PD +SP LI R Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIP----NLFKKVNSCVYVMPDF--LSPGAQSLIRR 241 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQF 296 + VADP RI+I EI+ WF NLP L + Sbjct: 242 MIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSY 280 >2YZA-A nrPDB Length = 276 Score = 303 bits (777), Expect = 7e-83, Method: Composition-based stats. Identities = 107/273 (39%), Positives = 146/273 (53%), Gaps = 12/273 (4%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRHP 76 Y +G G FG ++ +LT VAVK + R ++REI N + RHP Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +I++ +VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 131 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK EN LLD KI DFG S + + G+P Y APEV+ + Y G Sbjct: 132 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+WSCGV LY +L G PF+D P ++K I + IP+ + S L+ Sbjct: 190 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLM 243 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 + DP R +I +I+ H WF ++LP+ L E Sbjct: 244 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 276 >3MN3-A nrPDB Length = 271 Score = 303 bits (776), Expect = 9e-83, Method: Composition-based stats. Identities = 108/274 (39%), Positives = 151/274 (55%), Gaps = 13/274 (4%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLRHP 76 Y VK +G G+FG +L T + VA+K I + + ++REI R LRHP Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +I++ +VI + + +++EYA G EL++ I + SE EAR FFQQ++S V YCH + Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHK 123 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I HRDLK EN LLD +KI DFG S + K++ G+P Y APEV+ + Y G Sbjct: 124 IVHRDLKPENLLLDEHL--NVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 DVWSCGV LYVML PF+D P ++ I + Y++P +SP LI Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKN----ISNGVYTLPKF--LSPGAAGLIK 235 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 R+ + +P RISI EI WF +LP L+ Sbjct: 236 RMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPD 269 >2V7O-A nrPDB Length = 336 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 93/282 (32%), Positives = 140/282 (49%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREIINHRSLRH 75 +D Y +++G G F V R K + A K I + + ++RE R L+H Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I ++ + +GGEL+E I +SE +A Q+L V++ H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 136 QICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 I HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D D K Q+I + Y P+ ++PE Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWD----EDQHKLYQQIKAGAYDFPSPEWDTVTPEA 264 Query: 252 CHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNESNT 292 +LI+++ +PA RI+ + H W ++ A +M+ T Sbjct: 265 KNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQET 306 >3BHH-A nrPDB Length = 295 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 97/282 (34%), Positives = 142/282 (50%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 +D Y +DIG G F V R T A K I + + + ++RE R L+H Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 NIVR + I ++ + +GGEL+E I +SE +A QQ+L V +CH M Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 136 QICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 + HRDLK EN LL +K+ DFG + Q GTP Y++PEVL ++ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPEC 251 Y GK D+W+CGV LY++LVG PF D D K Q+I + Y P+ ++PE Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWD----EDQHKLYQQIKAGAYDFPSPEWDTVTPEA 237 Query: 252 CHLISRIFVADPATRISIPEIKTHSWF-LKNLPADLMNESNT 292 +LI+++ +PA RI+ E H W ++ A +M+ T Sbjct: 238 KNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQET 279 >5U6Y-A nrPDB Length = 461 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 93/277 (33%), Positives = 142/277 (51%), Gaps = 9/277 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHPNI 78 Y +++G G F V R L + A K I + + + ++RE R L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 VR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M + Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 121 Query: 139 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQEYDG 196 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Y G Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 180 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 K D+W+CGV LY++LVG PF D ++ R Y++ + + + P+ ++PE LI+ Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 257 RIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 ++ +P+ RI+ E H W ++ A M+ T Sbjct: 239 KMLTINPSKRITAAEALKHPWISHRSTVASCMHRQET 275 >3KK8-A nrPDB Length = 284 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 92/279 (32%), Positives = 136/279 (48%), Gaps = 8/279 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ---REIINHRSLRH 75 SD YD +++G G F V R K T A K I + Q RE R L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I + ++ + +GGEL+E I +SE +A QQ+L ++YCHS Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HR+LK EN LL +K+ DFG + GTP Y++PEVL + Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 K D+W+CGV LY++LVG PF D ++ R Y + + + Y P+ ++PE L Sbjct: 185 -SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI--KAGAYDYPSPEWDTVTPEAKSL 241 Query: 255 ISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 I + +P RI+ + W + A ++ +T Sbjct: 242 IDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDT 280 >2JC6-A nrPDB Length = 334 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 90/280 (32%), Positives = 137/280 (48%), Gaps = 10/280 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG--DKIDENVQREIINHRSLRHPNIV 79 ++F + +G+G F L +K T +L AVK I + + +++ EI R ++H NIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 +++ +P HL ++M+ SGGEL++RI G ++E +A +Q+L V Y H M I H Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 143 Query: 140 RDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 RDLK EN L ++ I DFG SK + GTP Y+APEVL ++ Y K Sbjct: 144 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKA 202 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHLIS 256 D WS GV Y++L G PF D + K ++IL +Y P IS I Sbjct: 203 VDCWSIGVIAYILLCGYPPFYDEND----SKLFEQILKAEYEFDSPYWDDISDSAKDFIR 258 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQF 296 + DP R + + H W + + + +Q Sbjct: 259 NLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQI 298 >4RGJ-A nrPDB Length = 520 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 101/339 (29%), Positives = 159/339 (46%), Gaps = 24/339 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLR 74 +++Y +K +G G+FG L RDK T A+K I + E++ RE+ + L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NI++ E + ++ + +GGEL++ I + RF E +A +Q+LSG++Y H Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHK 178 Query: 135 MQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 + HRDLK EN LL +KI DFG S + K +GT YIAP+VL Sbjct: 179 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG- 237 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPE 250 YD K D+WSCGV LY++L G PF E ++++ + KY+ P +IS + Sbjct: 238 TYDEK-CDIWSCGVILYILLSGCPPFNGSNEYD----ILKKVEAGKYTFDLPQFKKISDK 292 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTG--------SQFQEPEQP 302 LI ++ + A RIS + H W D +N QFQ ++ Sbjct: 293 AKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKL 352 Query: 303 MQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMD 341 Q+ ++ + S+ T F + + D +D Sbjct: 353 AQA--ALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLD 389 >2VZ6-A nrPDB Length = 313 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 93/277 (33%), Positives = 142/277 (51%), Gaps = 9/277 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHPNI 78 Y +++G G F V R L + A K I + + + ++RE R L+HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 VR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M + Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 143 Query: 139 HRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQEYDG 196 HRDLK EN LL +K+ DFG + Q GTP Y++PEVL + Y G Sbjct: 144 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-G 202 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 K D+W+CGV LY++LVG PF D ++ R Y++ + + + P+ ++PE LI+ Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKDLIN 260 Query: 257 RIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 ++ +P+ RI+ E H W ++ A M+ T Sbjct: 261 KMLTINPSKRITAAEALKHPWISHRSTVASCMHRQET 297 >4D28-A nrPDB Length = 446 Score = 300 bits (768), Expect = 8e-82, Method: Composition-based stats. Identities = 112/281 (39%), Positives = 157/281 (55%), Gaps = 13/281 (4%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHR 71 M +Y+ + IG G F + R+ T + VA+K + + + + ++REI + Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 +RHPNIVR EV+ + + + I++E+ +GGEL++RI + GR EDE+R +FQQL+ V++ Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLL 190 CHS + HRDLK EN LLD + LK+ DFG S + T GTP Y+APEVL Sbjct: 125 CHSKGVYHRDLKPENLLLDTN--GNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS 182 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Q YDG AD+WSCGV L+V+L G PF + + P YRK I + ++ P S E Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRK----INAAEFDCPPW--FSAE 236 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESN 291 LI RI +P TRI I IK WF KN E Sbjct: 237 VKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEE 277 >2W4O-A nrPDB Length = 349 Score = 297 bits (762), Expect = 4e-81, Method: Composition-based stats. Identities = 92/283 (32%), Positives = 144/283 (50%), Gaps = 9/283 (3%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 SD ++ ++G G + + K T++ A+K +++ + V+ EI L HPNI Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKK-TVDKKIVRTEIGVLLRLSHPNI 110 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 ++ KE+ TPT +++++E +GGEL++RI G +SE +A +Q+L V+Y H I Sbjct: 111 IKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIV 170 Query: 139 HRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN L +P LKI DFG SK K+ GTP Y APE+L Y G Sbjct: 171 HRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GP 229 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--PDDIRISPECCHLI 255 D+WS G+ Y++L G PF D + +RIL+ +Y P +S L+ Sbjct: 230 EVDMWSVGIITYILLCGFEPFYDERGDQF---MFRRILNCEYYFISPWWDEVSLNAKDLV 286 Query: 256 SRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 ++ V DP R++ + H W A+ ++ + QE Sbjct: 287 RKLIVLDPKKRLTTFQALQHPWVTGKA-ANFVHMDTAQKKLQE 328 >3SOA-A nrPDB Length = 444 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 94/312 (30%), Positives = 154/312 (49%), Gaps = 9/312 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRH 75 ++ Y +++G G F V R L + A I + + + ++RE R L+H Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNIVR + I H +I + +GGEL+E I +SE +A QQ+L V +CH M Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 + HR+LK EN LL +K+ DFG + Q GTP Y++PEVL + Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y GK D+W+CGV LY++LVG PF D ++ R Y++ + + + P+ ++PE Sbjct: 190 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--KAGAYDFPSPEWDTVTPEAKD 246 Query: 254 LISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNTGSQFQEPEQPMQSLDTIMQI 312 LI+++ +P+ RI+ E H W ++ A M+ T ++ + I+ + Sbjct: 247 LINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTV 306 Query: 313 ISEATIPAVRNR 324 + +VR + Sbjct: 307 MLATRNFSVRKQ 318 >4FG9-A nrPDB Length = 320 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 96/299 (32%), Positives = 141/299 (47%), Gaps = 14/299 (4%) Query: 8 TGPLDMPIMHDSDR----YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN- 62 G ++ P ++ YDF +G+G F L DK T++LVA+K I + + Sbjct: 2 LGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG 61 Query: 63 -VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFF 121 ++ EI ++HPNIV ++ + HL +IM+ SGGEL++RI G ++E +A Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 Q+L V Y H + I HRDLK EN L ++ I DFG SK S + GT Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGT 181 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 P Y+APEVL ++ Y K D WS GV Y++L G PF D + K ++IL +Y Sbjct: 182 PGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDA----KLFEQILKAEYE 236 Query: 241 I--PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQ 297 P IS I + DP R + + H W + D + Q + Sbjct: 237 FDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIK 295 >5YKS-A nrPDB Length = 377 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 95/268 (35%), Positives = 150/268 (55%), Gaps = 11/268 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---NVQREIINHRSLRHPNI 78 YD K +G G+F V +L R T E VAVK I++ ++ +E+ + ++HPNI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 VR EVI T T L +I+E GG++++ I + +ED A+ +F Q++ +SYCH + + Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN + +K+ DFG+S + ++ G+ AY APE+LL EYD Sbjct: 157 VHRDLKPENVVFFEKQ-GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 D+WS GV L++++ G PF++ + +T+ I+ KY++P +S EC LI+R Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEAND----SETLTMIMDCKYTVP--SHVSKECKDLITR 269 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPAD 285 + DP R S+ EI+ H W P+ Sbjct: 270 MLQRDPKRRASLEEIENHPWLQGVDPSP 297 >3MV5-A nrPDB Length = 342 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 104/344 (30%), Positives = 163/344 (47%), Gaps = 44/344 (12%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV----QREIINHRSLRH 75 + ++++K +G G FG L+++K T A+K +++ + ++ E ++ RH Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS- 134 P + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y HS Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 129 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYIAPEVLLRQE 193 + +RDLKLEN +LD +KI DFG K + + K+ GTP Y+APEVL + Sbjct: 130 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 187 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y G+ D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 188 Y-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPR--TLGPEAKS 240 Query: 254 LISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 L+S + DP R+ EI H +F A ++ + + P +P Sbjct: 241 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----AGIVWQHVYEKKLSPPFKP------ 289 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNL------DLDDDMDDFDSE 346 Q+ SE R D+ T + D DD M+ DSE Sbjct: 290 --QVTSETD-----TRYFDEEFTAQMITITPPDQDDSMECVDSE 326 >2JAM-A nrPDB Length = 304 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 87/263 (33%), Positives = 137/263 (52%), Gaps = 6/263 (2%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSLRHPNIVR 80 + F++ +GSG F L++ +LT +L A+K I++ ++ ++ EI + ++H NIV Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVT 70 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 +++ + TH ++M+ SGGEL++RI G ++E +A QQ+LS V Y H I HR Sbjct: 71 LEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 130 Query: 141 DLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIA 199 DLK EN L L ++ I DFG SK + + GTP Y+APEVL ++ Y K Sbjct: 131 DLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPY-SKAV 188 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIF 259 D WS GV Y++L G PF + E + + K + ++ P IS I + Sbjct: 189 DCWSIGVITYILLCGYPPFYEETESKLFEKIKEGY--YEFESPFWDDISESAKDFICHLL 246 Query: 260 VADPATRISIPEIKTHSWFLKNL 282 DP R + + +H W N Sbjct: 247 EKDPNERYTCEKALSHPWIDGNT 269 >3F3Z-A nrPDB Length = 277 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 10/271 (3%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPNIVR 80 Y IG G++G ++ K T+ A K I + D + ++EI +SL HPNI+R Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIR 70 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 E T + ++ME +GGEL+ER+ + F E +A + +LS V+YCH + + HR Sbjct: 71 LYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHR 130 Query: 141 DLKLENTL-LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIA 199 DLK EN L L SP LK+ DFG + ++ VGTP Y++P+VL G Sbjct: 131 DLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYGPEC 188 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP--DDIRISPECCHLISR 257 D WS GV +YV+L G PF P + + + +I ++ P D + +SP+ LI R Sbjct: 189 DEWSAGVMMYVLLCGYPPFSAPTD----SEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMN 288 + P RI+ + H WF K L + N Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQLSSSPRN 275 >2HAK-A nrPDB Length = 328 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 106/283 (37%), Positives = 157/283 (55%), Gaps = 17/283 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREIINHRSLRHPN 77 Y K IG GNF +L R LT VAVK I++ + + RE+ + L HPN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 135 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLDG +KI DFG+S + ++ + G+P Y APE+ ++YDG Sbjct: 136 VHRDLKAENLLLDGDM--NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWS GV LY ++ G+ PF+ ++ ++ +R+L KY IP +S +C +L+ + Sbjct: 194 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIP--FYMSTDCENLLKK 247 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 + V +P R S+ +I W ++ +E + EP+ Sbjct: 248 LLVLNPIKRGSLEQIMKDRWM------NVGHEEEELKPYTEPD 284 >6C9D-A nrPDB Length = 459 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 106/283 (37%), Positives = 156/283 (55%), Gaps = 17/283 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQREIINHRSLRHPN 77 Y K IG GNF +L R LT VAVK I++ + + RE+ + L HPN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IV+ EVI T L ++MEYASGGE+++ + GR E EAR F+Q++S V YCH I Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 141 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 HRDLK EN LLDG +KI DFG+S + ++ G+P Y APE+ ++YDG Sbjct: 142 VHRDLKAENLLLDGDM--NIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGP 199 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 DVWS GV LY ++ G+ PF+ ++ ++ +R+L KY IP +S +C +L+ + Sbjct: 200 EVDVWSLGVILYTLVSGSLPFDG----QNLKELRERVLRGKYRIP--FYMSTDCENLLKK 253 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 + V +P R S+ +I W ++ +E + EP+ Sbjct: 254 LLVLNPIKRGSLEQIMKDRWM------NVGHEEEELKPYTEPD 290 >4CQG-A nrPDB Length = 331 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 94/276 (34%), Positives = 147/276 (53%), Gaps = 12/276 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPNIV 79 Y+ + IG+G F +L LT E+VA+K +++ + V+ EI +SLRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICH 139 + V+ T + +++EY GGEL++ I + R SE+E R F+Q+LS V+Y HS H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAH 130 Query: 140 RDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 RDLK EN L D + +LK+ DFG + G+ AY APE++ + Y G Sbjct: 131 RDLKPENLLFDENH--KLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGS 188 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISR 257 ADVWS G+ LYV++ G PF+D Y+K ++ KY +P +SP L+ + Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR----GKYEVPKW--LSPSSILLLQQ 242 Query: 258 IFVADPATRISIPEIKTHSWFLKNLPADLMNESNTG 293 + DP RIS+ + H W +++ + +S T Sbjct: 243 MLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTP 278 >2JDO-A nrPDB Length = 342 Score = 287 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 102/358 (28%), Positives = 164/358 (45%), Gaps = 39/358 (10%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR--- 65 G +D + + +D++K +G G FG L+R+K T A+K + + I ++ Sbjct: 1 GAMDPKVTMN--DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV 58 Query: 66 -EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 E ++ RHP + K T L +MEYA+GGEL+ + F+E+ ARF+ + Sbjct: 59 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 118 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAY 183 ++S + Y HS + +RD+KLEN +LD +KI DFG K + K+ GTP Y Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLDKD--GHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +APEVL +Y G+ D W GV +Y M+ G PF + +D+ + + IL + P Sbjct: 177 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHERLFELILMEEIRFPR 231 Query: 244 DIRISPECCHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 +SPE L++ + DP R+ E+ H +FL D++ + + Sbjct: 232 --TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK-----KLLP 284 Query: 299 PEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGE 356 P +P V R DD T D +DS +++D E Sbjct: 285 PFKP-------------QVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQREE 329 >4YNZ-A nrPDB Length = 342 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 105/332 (31%), Positives = 173/332 (52%), Gaps = 36/332 (10%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---NVQREIINHRSLRHPNI 78 Y K +G G G+ +L +T + VA+K + R + V+REI + + HP++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 ++ +V +L +++E+ SGGEL++ + GR + EAR FF+Q++S + +CHS IC Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 131 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 HRDLK EN LLD ++I DFG + V S +++ G+P Y PEV+ ++YDG+ Sbjct: 132 HRDLKPENLLLDE--RNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 ADVWSCGV L+ +LVGA PF+D R+ ++++ + +P I P+C L+ + Sbjct: 190 ADVWSCGVILFALLVGALPFDDDN----LRQLLEKVKRGVFHMPHF--IPPDCQSLLRGM 243 Query: 259 FVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATI 318 D A R+++ I+ H W++ G EPEQP+ I + S I Sbjct: 244 IEVDAARRLTLEHIQKHIWYI------------GGKNEPEPEQPIPRKVQIRSLPSLEDI 291 Query: 319 PA-------------VRNRCLDDFMTDNLDLD 337 RN+ L D +++ + + Sbjct: 292 DPDVLDSMHSLGCFRDRNKLLQDLLSEEENQE 323 >5KCV-A nrPDB Length = 460 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 97/326 (29%), Positives = 155/326 (47%), Gaps = 38/326 (11%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV----QREIINHRSLRH 75 + ++++K +G G FG L+++K T A+K +++ + ++ E ++ RH Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS- 134 P + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y HS Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 281 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYIAPEVLLRQE 193 + +RDLKLEN +LD +KI DFG K + + K+ GTP Y+APEVL + Sbjct: 282 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 339 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y G+ D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 340 Y-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPR--TLGPEAKS 392 Query: 254 LISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 L+S + DP R+ EI H +F A ++ + + P +P Sbjct: 393 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----AGIVWQHVYEKKLSPPFKP------ 441 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNL 334 Q+ SE R D+ T + Sbjct: 442 --QVTSETD-----TRYFDEEFTAQM 460 >4UZD-A nrPDB Length = 287 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 90/291 (30%), Positives = 149/291 (51%), Gaps = 16/291 (5%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK----IDENVQREII 68 M + ++ + +G G FG L R+K +K ++A+K + + ++ ++RE+ Sbjct: 1 MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVE 60 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 LRHPNI+R T + +I+EYA G +Y + +F E + +L + Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 +SYCHS ++ HRD+K EN LL A LKI DFG+S S+ + GT Y+ PE+ Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGS--AGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEM 177 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + + +D K D+WS GV Y LVG PF E Y++T +RI V+++ PD ++ Sbjct: 178 IEGRMHDEK-VDLWSLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDF--VT 230 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKN--LPADLMNESNTGSQFQ 297 LISR+ +P+ R + E+ H W N P++ N+ + + + Sbjct: 231 EGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAAAALE 281 >4D2V-A nrPDB Length = 356 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 92/287 (32%), Positives = 147/287 (51%), Gaps = 16/287 (5%) Query: 15 IMHDSDR----YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--NVQREII 68 M D D Y+ + IG+G F +L LT E+VA+K +++ + ++ EI Sbjct: 20 HMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIE 79 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 ++LRH +I + V+ T + +++EY GGEL++ I + R SE+E R F+Q++S Sbjct: 80 ALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSA 139 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAP 186 V+Y HS HRDLK EN L D +LK+ DFG ++ G AY AP Sbjct: 140 VAYVHSQGYAHRDLKPENLLFDE--YHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 E++ + Y G ADVWS G+ LYV++ G PF+D + +I+ KY +P Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAA----LVAKIMRGKYDVPKW-- 251 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTG 293 +SP L+ ++ DP RIS+ + H W +++ + +S Sbjct: 252 LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNP 298 >1FOT-A nrPDB Length = 318 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 87/308 (28%), Positives = 147/308 (47%), Gaps = 21/308 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHP 76 + ++ +G+G+FG L+R + A+K +++ + E+ E + + HP Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + +IM+Y GGEL+ + + RF A+F+ ++ + Y HS Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKD 126 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I +RDLK EN LLD + +KI DFG++K + + GTP YIAPEV+ + Y+ Sbjct: 127 IIYRDLKPENILLDKN--GHIKITDFGFAKYVPDVT--YTLCGTPDYIAPEVVSTKPYN- 181 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 K D WS G+ +Y ML G PF D KT ++IL+ + P + + L+S Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNT----MKTYEKILNAELRFPPF--FNEDVKDLLS 235 Query: 257 RIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQ 311 R+ D + R+ ++K H WF + + L++ N + ++ P Q Q + Sbjct: 236 RLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSR-NIETPYEPPIQQGQGDTSQFD 294 Query: 312 IISEATIP 319 E I Sbjct: 295 KYPEEDIN 302 >3HDN-A nrPDB Length = 373 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 94/299 (31%), Positives = 144/299 (48%), Gaps = 20/299 (6%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR 65 + GP P SD + F+K IG G+FG L R K + AVK +++ + + ++ Sbjct: 25 INLGPSSNPHAKPSD-FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEK 83 Query: 66 EII-----NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 I+ ++++HP +V T L +++Y +GGEL+ + F E ARF Sbjct: 84 HIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARF 143 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VG 179 + ++ S + Y HS+ I +RDLK EN LLD + + DFG K ++ H+ ST G Sbjct: 144 YAAEIASALGYLHSLNIVYRDLKPENILLDSQ--GHIVLTDFGLCKENIEHNSTTSTFCG 201 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 TP Y+APEVL +Q YD + D W G LY ML G PF Y + + L +K Sbjct: 202 TPEYLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 260 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIP----EIKTHSWFLKNLPADLMNESNTGS 294 + I+ HL+ + D R+ EIK+H +F DL+N+ T Sbjct: 261 N------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPP 313 >2J90-A nrPDB Length = 304 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 95/300 (31%), Positives = 152/300 (50%), Gaps = 17/300 (5%) Query: 4 APVTTGPLDMPIM-HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD----- 57 + V G ++ D Y+ +++GSG F + R R K T + A K+I++ Sbjct: 9 SGVDLGTENLYFQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSR 68 Query: 58 --KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE 115 E ++RE+ R +RHPNI+ ++ T + +I+E SGGEL++ + +E Sbjct: 69 RGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTE 128 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQ 173 DEA F +Q+L GV Y HS +I H DLK EN +L P PR+K+ DFG + ++ Sbjct: 129 DEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE 188 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 K+ GTP ++APE++ + G AD+WS GV Y++L GA PF ++T+ Sbjct: 189 FKNIFGTPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLG----ETKQETLTN 243 Query: 234 ILSVKYSIPDDI--RISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESN 291 I +V Y ++ S I R+ V DP R++I + HSW ++ E + Sbjct: 244 ISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDS 303 >3D2K-A nrPDB Length = 272 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 89/277 (32%), Positives = 144/277 (51%), Gaps = 14/277 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK----IDENVQ 64 GPL + +D + +G G FG L R++ +K ++A+K + + ++ ++ Sbjct: 1 GPLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLR 60 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 RE+ LRHPNI+R T + +I+EYA G +Y + RF E + + Sbjct: 61 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITE 120 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 L + +SYCHS ++ HRD+K EN LL + LKI DFG+S S+ + GT Y+ Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSN--GELKIADFGWS-VHAPSSRRTTLCGTLDYL 177 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 PE++ + +D K D+WS GV Y LVG PF E Y++T +RI V+++ PD Sbjct: 178 PPEMIEGRMHDEK-VDLWSLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDF 232 Query: 245 IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 ++ LISR+ + + R+++ E+ H W N Sbjct: 233 --VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKAN 267 >4NIF-A nrPDB Length = 333 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 89/282 (31%), Positives = 136/282 (48%), Gaps = 13/282 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPN 77 SD Y + IG G++ + K T AVK I++ + EI +HPN Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE---EIEILLRYGQHPN 63 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I+ K+V H+ ++ E GGEL ++I FSE EA F + V Y HS + Sbjct: 64 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 138 CHRDLKLENTL-LDGSPAPR-LKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQEY 194 HRDLK N L +D S P L+ICDFG++K + + T ++APEVL RQ Y Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 183 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP--DDIRISPECC 252 D + D+WS G+ LY ML G PF + + + RI S K+++ + +S Sbjct: 184 D-EGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGKFTLSGGNWNTVSETAK 241 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK--NLPADLMNESNT 292 L+S++ DP R++ ++ H W + LP ++ + Sbjct: 242 DLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL 283 >2YCR-A nrPDB Length = 323 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 94/297 (31%), Positives = 137/297 (46%), Gaps = 22/297 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---------KIDENVQREIINH 70 D Y K +GSG G +L ++ T + VA+K I + NV+ EI Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + L HP I++ K + I++E GGEL++++ R E + +F Q+L V Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 131 YCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H I HRDLK EN LL +KI DFG+SK S ++ GTP Y+APEVL Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI-PD-DI 245 + + D WS GV L++ L G PF E R +I S KY+ P+ Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFL----KNLPADLMNESNTGSQFQE 298 +S + L+ ++ V DP R + E H W K DL++E N + + Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAKPQ 302 >2BPM-A nrPDB Length = 309 Score = 280 bits (716), Expect = 9e-76, Method: Composition-based stats. Identities = 80/293 (27%), Positives = 128/293 (43%), Gaps = 32/293 (10%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHRS 72 + D + + V+ IG G +GV R+KLT E+VA+K I + + REI + Sbjct: 3 LVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 62 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA--GRFSEDEARFFFQQLLSGVS 130 L HPNIV+ +VI T L ++ E+ +L + + + + + QLL G++ Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVL 189 +CHS ++ HRDLK +N L++ A +K+ DFG +++ V V T Y APE+L Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ--------------RIL 235 L +Y D+WS G M+ F E + + + Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 236 SVKYSIPDDIR---------ISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 K S P R + + L+S++ DP RIS H +F Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 292 >5XZW-A nrPDB Length = 471 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 82/276 (29%), Positives = 127/276 (46%), Gaps = 17/276 (6%) Query: 19 SDRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI--DENVQREIINHRSLRH 75 + + + +G G F + ++ T + AVK I + I + V RE+ + L H Sbjct: 194 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNH 253 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P IVR K ++ME+ SGG+L + + G ED R +Q+L+ + Y HSM Sbjct: 254 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 313 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY- 194 I HRDLK +N L++ +KI DFG +K S K+ GT AY+APEV+ ++ Sbjct: 314 GISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 373 Query: 195 -----------DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 + D+WS G +YV+L G PF + + Y++ + S Sbjct: 374 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG--SYHEGPLK 431 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 D RIS E I + DP R + + H W + Sbjct: 432 DFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIV 467 >5D9K-A nrPDB Length = 330 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 89/295 (30%), Positives = 155/295 (52%), Gaps = 26/295 (8%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLT---KELVAVKYIER-----GDKIDENVQREIIN 69 D +++ +K +G G+FG L++ ++L A+K +++ D++ ++R+I+ Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 + HP IV+ T L +I+++ GG+L+ R+ F+E++ +F+ +L + Sbjct: 88 E--VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 145 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEV 188 + HS+ I +RDLK EN LLD +K+ DFG SK S+ H + S GT Y+APEV Sbjct: 146 DHLHSLGIIYRDLKPENILLDEE--GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 203 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + R+ + + AD WS GV ++ ML G PF+ +D ++T+ IL K +P +S Sbjct: 204 VNRRGHT-QSADWWSFGVLMFEMLTGTLPFQG----KDRKETMTMILKAKLGMPQF--LS 256 Query: 249 PECCHLISRIFVADPATRISI-----PEIKTHSWFLKNLPADLMNESNTGSQFQE 298 PE L+ +F +PA R+ EIK HS+F + + + F+ Sbjct: 257 PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFS-TIDWNKLYRREIHPPFKP 310 >4JG6-A nrPDB Length = 355 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 89/283 (31%), Positives = 136/283 (48%), Gaps = 13/283 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPN 77 +D Y+ +DIG G++ V + K T AVK I++ + EI +HPN Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE---EIEILLRYGQHPN 90 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 I+ K+V ++ ++ E GGEL ++I FSE EA + V Y H+ + Sbjct: 91 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 150 Query: 138 CHRDLKLENTL-LDGSPAPR-LKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQEY 194 HRDLK N L +D S P ++ICDFG++K + + T ++APEVL RQ Y Sbjct: 151 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGY 210 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP--DDIRISPECC 252 D D+WS GV LY ML G PF + + + + RI S K+S+ +S Sbjct: 211 DA-ACDIWSLGVLLYTMLTGYTPFANGPD-DTPEEILARIGSGKFSLSGGYWNSVSDTAK 268 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLK--NLPADLMNESNTG 293 L+S++ DP R++ + H W + LP +N + Sbjct: 269 DLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAP 311 >3I6U-A nrPDB Length = 419 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 92/289 (31%), Positives = 134/289 (46%), Gaps = 22/289 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---------KIDENVQREIINH 70 D Y K +GSG G +L ++ T + VA++ I + NV+ EI Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + L HP I++ K + I++E GGEL++++ R E + +F Q+L V Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 131 YCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H I HRDLK EN LL +KI DFG+SK S ++ GTP Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI-PD-DI 245 + + D WS GV L++ L G PF E R +I S KY+ P+ Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFL----KNLPADLMNES 290 +S + L+ ++ V DP R + E H W K DL++E Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEE 419 >3GUB-A nrPDB Length = 295 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 95/291 (32%), Positives = 153/291 (52%), Gaps = 16/291 (5%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK-------IDENVQREIINH 70 D YD +++GSG F V + R+K T A K+I++ E+++RE+ Sbjct: 9 VDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + ++HPN++ EV T + +I E +GGEL++ + +E+EA F +Q+L+GV Sbjct: 69 KEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVY 128 Query: 131 YCHSMQICHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 Y HS+QI H DLK EN LLD + P PR+KI DFG + ++ K+ GTP ++APE+ Sbjct: 129 YLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEI 188 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--R 246 + + G AD+WS GV Y++L GA PF ++T+ + +V Y D+ Sbjct: 189 VNYEPL-GLEADMWSIGVITYILLSGASPFLGD----TKQETLANVSAVNYEFEDEYFSN 243 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQ 297 S I R+ V DP R++I + H W ++ + + QF+ Sbjct: 244 TSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAWSHPQFE 294 >3UTO-A nrPDB Length = 573 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 82/275 (29%), Positives = 134/275 (48%), Gaps = 9/275 (3%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGDKIDENVQREI 67 P+++ H D YD +++G+G FGV + ++ T A K + + E V++EI Sbjct: 146 QPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEI 205 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLL 126 LRHP +V + + +I E+ SGGEL+E++ + SEDEA + +Q+ Sbjct: 206 QTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVC 265 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + H H DLK EN + + LK+ DFG + K T GT + AP Sbjct: 266 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 325 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 EV + G D+WS GV Y++L G PF + +T++ + S +++ D Sbjct: 326 EVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGEND----DETLRNVKSCDWNMDDSAF 380 Query: 247 --ISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 IS + I ++ +ADP TR++I + H W Sbjct: 381 SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >5JZN-A nrPDB Length = 280 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 78/264 (29%), Positives = 131/264 (49%), Gaps = 7/264 (2%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN--VQREIINHRSLRHP 76 ++RY + IG GNF V + ++ T A+K I++ + +Q E+ R ++HP Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 NIV E + PT L ++ME GG+L++ I + +++E +A L S + Y HS+ Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 137 ICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 I HRD+K EN L+ + LK+ DFG + ++ + GTP Y+APE++ Y Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT--IVDGPLYTVCGTPTYVAPEIIAETGY 195 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 G D+W+ GV Y++L G PF + ++ + V + P +S L Sbjct: 196 -GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 254 Query: 255 ISRIFVADPATRISIPEIKTHSWF 278 I+ + + D R S ++ H W Sbjct: 255 ITMMLLVDVDQRFSAVQVLEHPWV 278 >2YAB-A nrPDB Length = 361 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 89/275 (32%), Positives = 142/275 (51%), Gaps = 16/275 (5%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-------DENVQREII 68 D YD +++GSG F + + R+K T A K+I++ E ++RE+ Sbjct: 8 QKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVS 67 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 R + HPNI+ +V T + +I+E SGGEL++ + SE+EA F +Q+L G Sbjct: 68 ILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 129 VSYCHSMQICHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 V+Y H+ +I H DLK EN LLD + P P +K+ DFG + + K+ GTP ++AP Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI- 245 E++ + G AD+WS GV Y++L GA PF ++T+ I +V Y ++ Sbjct: 188 EIVNYEPL-GLEADMWSIGVITYILLSGASPFLGD----TKQETLANITAVSYDFDEEFF 242 Query: 246 -RISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 + S I ++ V + R++I E H W Sbjct: 243 SQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >6FDY-U nrPDB Length = 276 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 13/283 (4%) Query: 8 TGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR-DKLTKELVAVKYIERGDKID---ENV 63 GP P D + + +GSG + K T+E+VA+K + + EN+ Sbjct: 1 AGPGWGP--PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL 58 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 EI + +RHP+IV+ K+ ++ +IME+ +GG+L I E AR F Q Sbjct: 59 LTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQ 118 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 QL S + + H I H DLK +N LL P LK+ DFG+++ + G+P Y Sbjct: 119 QLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLY 178 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK-YSIP 242 +APE++ +++YD + D+WS GV LY L G PF R + + ++I S + +P Sbjct: 179 MAPEMVCQRQYDAR-VDLWSMGVILYEALFGQPPFAS----RSFSELEEKIRSNRVIELP 233 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWF-LKNLPA 284 +S +C L+ R+ DP+ RIS + H W L+++P+ Sbjct: 234 LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >1PHK-A nrPDB Length = 298 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 83/297 (27%), Positives = 130/297 (43%), Gaps = 24/297 (8%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI----------ERGDKI 59 P + Y+ + +G G V R K T + AVK I E ++ Sbjct: 7 PGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQEL 66 Query: 60 DENVQREIINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEA 118 E +E+ R + HPNI++ K+ T T ++ + GEL++ + SE E Sbjct: 67 REATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKET 126 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 R + LL + H + I HRDLK EN LLD +K+ DFG+S + + Sbjct: 127 RKIMRALLEVICALHKLNIVHRDLKPENILLDDDM--NIKLTDFGFSCQLDPGEKLREVC 184 Query: 179 GTPAYIAPEVLL-----RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 GTP+Y+APE++ GK D+WS GV +Y +L G+ PF R ++ Sbjct: 185 GTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH----RKQMLMLRM 240 Query: 234 ILSVKYSI--PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 I+S Y P+ S L+SR V P R + E H +F + + ++ + Sbjct: 241 IMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEEVRH 297 >1KOA-A nrPDB Length = 491 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 82/275 (29%), Positives = 134/275 (48%), Gaps = 9/275 (3%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGDKIDENVQREI 67 P+++ H D YD +++G+G FGV + ++ T A K + + E V++EI Sbjct: 40 QPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEI 99 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLL 126 LRHP +V + + +I E+ SGGEL+E++ + SEDEA + +Q+ Sbjct: 100 QTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVC 159 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + H H DLK EN + + LK+ DFG + K T GT + AP Sbjct: 160 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 219 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 EV + G D+WS GV Y++L G PF + +T++ + S +++ D Sbjct: 220 EVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGEND----DETLRNVKSCDWNMDDSAF 274 Query: 247 --ISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 IS + I ++ +ADP TR++I + H W Sbjct: 275 SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >2Z7Q-A nrPDB Length = 321 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 87/293 (29%), Positives = 145/293 (49%), Gaps = 22/293 (7%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDK---LTKELVAVKYIERGDKIDENVQR---EIINHR 71 D ++ +K +G G+FG L+R + L A+K +++ + R E Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 + HP +V+ T L +I+++ GG+L+ R+ F+E++ +F+ +L G+ + Sbjct: 86 DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 145 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 190 HS+ I +RDLK EN LLD +K+ DFG SK ++ H + S GT Y+APEV+ Sbjct: 146 LHSLGIIYRDLKPENILLDEE--GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 203 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 RQ + AD WS GV ++ ML G+ PF+ +D ++T+ IL K +P +S E Sbjct: 204 RQGHSH-SADWWSYGVLMFEMLTGSLPFQG----KDRKETMTLILKAKLGMPQF--LSTE 256 Query: 251 CCHLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 L+ +F +PA R+ EIK H F + + + F+ Sbjct: 257 AQSLLRALFKRNPANRLGSGPDGAEEIKRH-VFYSTIDWNKLYRREIKPPFKP 308 >4L42-A nrPDB Length = 346 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 85/339 (25%), Positives = 151/339 (44%), Gaps = 29/339 (8%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR---DKLTKELVAVKYIERGD 57 M V GP + + ++ ++ +G G +G +R T ++ A+K +++ Sbjct: 3 MSETSVNRGPEKI----RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM 58 Query: 58 KIDE-----NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR 112 + + + E ++HP IV T L +I+EY SGGEL+ ++ G Sbjct: 59 IVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 118 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 F ED A F+ ++ + + H I +RDLK EN +L+ +K+ DFG K S+ Sbjct: 119 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDG 176 Query: 173 QPKST-VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 T GT Y+APE+L+R ++ + D WS G +Y ML GA PF + +KTI Sbjct: 177 TVTHTFCGTIEYMAPEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTI 231 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADL 286 +IL K ++P ++ E L+ ++ + A+R+ E++ H +F +L Sbjct: 232 DKILKCKLNLPPY--LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 289 Query: 287 MNESNTGS--QFQEPEQPMQSLDTIMQIISEATIPAVRN 323 + + E+ + D+ + P Sbjct: 290 LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDST 328 >3TAC-A nrPDB Length = 361 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 88/306 (28%), Positives = 137/306 (44%), Gaps = 21/306 (6%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----- 60 V G + + D Y+ + IG G F V R ++ T + AVK ++ Sbjct: 12 VPRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS 71 Query: 61 -ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG----RFSE 115 E+++RE L+HP+IV E + L ++ E+ G +L I +SE Sbjct: 72 TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE 131 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPR-LKICDFGYSKSSVLHSQ- 173 A + +Q+L + YCH I HRD+K LL +K+ FG + Sbjct: 132 AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLV 191 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 VGTP ++APEV+ R+ Y GK DVW CGV L+++L G PF +E + + Sbjct: 192 AGGRVGTPHFMAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEG 245 Query: 234 ILSVKYSIPD--DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNES 290 I+ KY + IS L+ R+ + DPA RI++ E H W ++ A ++ Sbjct: 246 IIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLP 305 Query: 291 NTGSQF 296 T Q Sbjct: 306 ETVEQL 311 >6CMJ-A nrPDB Length = 321 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 97/289 (33%), Positives = 144/289 (49%), Gaps = 24/289 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID------------ENVQREI 67 D+Y +IG G++GV +L ++ A+K + + I E V +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 68 INHRSLRHPNIVRFKEVILTP--THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 + L HPN+V+ EV+ P HL ++ E + G + E + SED+ARF+FQ L Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYFQDL 152 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYI 184 + G+ Y H +I HRD+K N L+ +KI DFG S + +TVGTPA++ Sbjct: 153 IKGIEYLHYQKIIHRDIKPSNLLVGED--GHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 185 APEVLL--RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 APE L R+ + GK DVW+ GVTLY + G PF D +I S P Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERIMCLHSKIKSQALEFP 266 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESN 291 D I+ + LI+R+ +P +RI +PEIK H W ++ L +E Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDE 315 >5N23-A nrPDB Length = 352 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 85/319 (26%), Positives = 152/319 (47%), Gaps = 20/319 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRH 75 D+++ ++ +G+G+FG L++ K T A+K +++ + E+ E +++ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L +++EYA GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +K+ DFG++K V P + GTP Y+APE++L + Y+ Sbjct: 162 DLIYRDLKPENLLID--QQGYIKVADFGFAKR-VKGRTPWTLCGTPEYLAPEIILSKGYN 218 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y ++I+S K P S + L+ Sbjct: 219 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP--SHFSSDLKDLL 271 Query: 256 SRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 + D R + +IK H WF + + + F + Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI-AIYQRKVEAPFIPKFKGPGDTSNFD 330 Query: 311 QIISEATIPAVRNRCLDDF 329 E ++ +C +F Sbjct: 331 DYEEEEIRVSINEKCGKEF 349 >2Y7J-A nrPDB Length = 365 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 79/275 (28%), Positives = 129/275 (46%), Gaps = 19/275 (6%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG---------DKIDENVQREIINHR 71 +YD IG G V R + T AVK +E +++ E +RE R Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 72 SL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 + HP+I+ + + + + ++ + GEL++ + SE E R + LL VS Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 189 + H+ I HRDLK EN LLD + ++++ DFG+S + + GTP Y+APE+L Sbjct: 215 FLHANNIVHRDLKPENILLDDNM--QIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILK 272 Query: 190 ----LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 GK D+W+CGV L+ +L G+ PF + R ++ ++S P+ Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG--QYQFSSPEWD 330 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 S LISR+ DP R++ + H +F + Sbjct: 331 DRSSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >3IS5-A nrPDB Length = 285 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 82/282 (29%), Positives = 132/282 (46%), Gaps = 13/282 (4%) Query: 7 TTGPLDMPIMHDSDR-YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKIDENV 63 ++G ++ D + F + +GSG FG L+ ++ + +K I + E + Sbjct: 8 SSGRENLYFQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQI 67 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA----GRFSEDEAR 119 + EI +SL HPNI++ EV ++ I+ME GGEL ERI +A SE Sbjct: 68 EAEIEVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVA 127 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 +Q+++ ++Y HS + H+DLK EN L D SP +KI DFG ++ + Sbjct: 128 ELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAA 187 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GT Y+APEV R D+WS GV +Y +L G PF +K + + Sbjct: 188 GTALYMAPEVFKRDV--TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYA 245 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 ++P+ L+ ++ DP R S ++ H WF + Sbjct: 246 VEC---RPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4PDS-A nrPDB Length = 347 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 80/276 (28%), Positives = 125/276 (45%), Gaps = 17/276 (6%) Query: 19 SDRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI--DENVQREIINHRSLRH 75 + + + +G G F + ++ T + +VK I + I + V RE+ + L H Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNH 88 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P IVR K ++ME+ SGG+L + + G ED R +Q+L+ + Y HSM Sbjct: 89 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 148 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY- 194 I HRDLK +N L++ +KI FG +K S K+ GT AY+APEV+ ++ Sbjct: 149 GISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 208 Query: 195 -----------DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 + D+WS G +YV+L G PF + + Y++ + S Sbjct: 209 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG--SYHEGPLK 266 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 D RIS E I + DP R + + H W Sbjct: 267 DFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >1KOB-A nrPDB Length = 387 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 78/278 (28%), Positives = 130/278 (46%), Gaps = 9/278 (3%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-NVQREI 67 P+++ D YD ++++GSG FGV +K T + K+I +D+ V+ EI Sbjct: 40 QPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEI 99 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLL 126 L HP ++ + + +I+E+ SGGEL++RI + SE E + +Q Sbjct: 100 SIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQAC 159 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + H I H D+K EN + + A +KI DFG + K T T + AP Sbjct: 160 EGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAP 219 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI- 245 E++ R+ G D+W+ GV YV+L G PF D +T+Q + + +D Sbjct: 220 EIVDREPV-GFYTDMWAIGVLGYVLLSGLSPFAG----EDDLETLQNVKRCDWEFDEDAF 274 Query: 246 -RISPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 +SPE I + +P R+++ + H W + Sbjct: 275 SSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >2A27-A nrPDB Length = 321 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 88/282 (31%), Positives = 142/282 (50%), Gaps = 16/282 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK-------IDE 61 G D YD +++GSG F + + R+K T A K+I++ E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFF 121 ++RE+ R + H N++ +V T + +I+E SGGEL++ + SE+EA F Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF 120 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENT-LLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVG 179 +Q+L GV+Y H+ +I H DLK EN LLD + P P +K+ DFG + + K+ G Sbjct: 121 IKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFG 180 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 TP ++APE++ + G AD+WS GV Y++L GA PF ++T+ I +V Y Sbjct: 181 TPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGD----TKQETLANITAVSY 235 Query: 240 SIPDDI--RISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 ++ + S I ++ V + R++I E H W Sbjct: 236 DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5X3F-B nrPDB Length = 393 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 152/319 (47%), Gaps = 21/319 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRH 75 D++D +K +G+G+FG L++ K + A+K +++ + E+ E +++ Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L ++MEY +GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 144 PFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 203 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 204 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 259 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y ++I+S K P S + L+ Sbjct: 260 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP--SHFSSDLKDLL 312 Query: 256 SRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 + D R + +IK H WF + + + F + Sbjct: 313 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI-AIYQRKVEAPFIPKFKGPGDTSNFD 371 Query: 311 QIISEATIPAVRNRCLDDF 329 E ++ +C +F Sbjct: 372 DYEEEEIRVSINEKCGKEF 390 >1ZWS-A nrPDB Length = 288 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 87/282 (30%), Positives = 139/282 (49%), Gaps = 16/282 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK-------IDE 61 G D YD +++GSG F + + R+K T A K+I++ E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFF 121 ++RE+ R + H N++ +V T + +I+E SGGEL++ + SE+EA F Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF 120 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKSTVG 179 +Q+L GV+Y H+ +I H DLK EN +L P P +K+ DFG + + K+ G Sbjct: 121 IKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFG 180 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 TP ++APE++ + G AD+WS GV Y++L GA PF ++T+ I SV Y Sbjct: 181 TPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGD----TKQETLANITSVSY 235 Query: 240 SIPDDI--RISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 ++ S I ++ V + R++I E H W Sbjct: 236 DFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4WB7-A nrPDB Length = 405 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 151/319 (47%), Gaps = 21/319 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRH 75 D+++ +K +G+G+FG L++ K T A+K +++ + E+ E +++ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V+ + ++L ++MEY GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 215 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 216 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 271 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D W+ GV +Y M G PF + + Y ++I+S K P S + L+ Sbjct: 272 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP--SHFSSDLKDLL 324 Query: 256 SRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 + D R + +IK H WF + + + F + Sbjct: 325 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI-AIYQRKVEAPFIPKFKGPGDTSNFD 383 Query: 311 QIISEATIPAVRNRCLDDF 329 E ++ +C +F Sbjct: 384 DYEEEEIRVSINEKCGKEF 402 >4RLP-A nrPDB Length = 288 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 80/296 (27%), Positives = 143/296 (48%), Gaps = 28/296 (9%) Query: 22 YDFVKDIGSGNFGVARLMR---DKLTKELVAVKYIERGDKIDE-----NVQREIINHRSL 73 ++ ++ +G G +G +R T ++ A+K +++ + + + E + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 +HP IV T L +I+EY SGGEL+ ++ G F ED A F+ ++ + + H Sbjct: 67 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 126 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQ 192 I +RDLK EN +L+ +K+ DFG K S+ T GT Y+APE+L+R Sbjct: 127 QKGIIYRDLKPENIMLNHQ--GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 ++ + D WS G +Y ML GA PF + +KTI +IL K ++P ++ E Sbjct: 185 GHN-RAVDWWSLGALMYDMLTGAPPFTG----ENRKKTIDKILKCKLNLPPY--LTQEAR 237 Query: 253 HLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPM 303 L+ ++ + A+R+ E++ H +F +L+ + + P +P+ Sbjct: 238 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR-----KVEPPFKPL 288 >6E9W-A nrPDB Length = 443 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 90/278 (32%), Positives = 129/278 (46%), Gaps = 18/278 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLR 74 ++ Y+ VK IG G FG +L+R K T+++ A+K + + + I + E Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 P +V+ +L ++MEY GG+L + N E ARF+ +++ + HS Sbjct: 161 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHS 219 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK--STVGTPAYIAPEVLL-- 190 M HRD+K +N LLD S LK+ DFG + + VGTP YI+PEVL Sbjct: 220 MGFIHRDVKPDNMLLDKS--GHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQ 277 Query: 191 -RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 Y G+ D WS GV LY MLVG PF Y K + + PDD IS Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH--KNSLTFPDDNDISK 335 Query: 250 ECCHLISRIFVADPATRI---SIPEIKTHSWFLKNLPA 284 E +LI D R+ + EIK H +F + A Sbjct: 336 EAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWA 372 >3COM-A nrPDB Length = 314 Score = 267 bits (682), Expect = 8e-72, Method: Composition-based stats. Identities = 69/273 (25%), Positives = 120/273 (43%), Gaps = 17/273 (6%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 D + +D ++ +G G++G K T ++VA+K + + E + +EI + Sbjct: 21 DSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE-IIKEISIMQ 79 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVS 130 P++V++ T L I+MEY G + + I +EDE Q L G+ Sbjct: 80 QCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLE 139 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 189 Y H M+ HRD+K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 140 YLHFMRKIHRDIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 197 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR--- 246 Y+ +AD+WS G+T M G P+ D ++ I + + P R Sbjct: 198 QEIGYNC-VADIWSLGITAIEMAEGKPPYADIHP-------MRAIFMIPTNPPPTFRKPE 249 Query: 247 -ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S + + V P R + ++ H + Sbjct: 250 LWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV 282 >3KN6-A nrPDB Length = 325 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 88/262 (33%), Positives = 136/262 (51%), Gaps = 11/262 (4%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEV 84 K +G G+F + R K + + AVK I + +++ N Q+EI + HPNIV+ EV Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK--RMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 H ++ME +GGEL+ERI FSE EA + ++L+S VS+ H + + HRDLK Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 145 ENTLL-DGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQEYDGKIADVW 202 EN L D + +KI DFG+++ +QP K+ T Y APE+L + YD + D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLW 193 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYR---KTIQRILSVKYSI--PDDIRISPECCHLISR 257 S GV LY ML G PF+ + + +++I +S +S E LI Sbjct: 194 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 253 Query: 258 IFVADPATRISIPEIKTHSWFL 279 + DP R+ + ++ + W Sbjct: 254 LLTVDPNKRLKMSGLRYNEWLQ 275 >1VZO-A nrPDB Length = 355 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 85/301 (28%), Positives = 142/301 (47%), Gaps = 26/301 (8%) Query: 20 DRYDFVKDIGSGNFGVARLMR---DKLTKELVAVKYIERGD-----KIDENVQREIINHR 71 + ++ +K +G+G +G L+R T +L A+K +++ K E+ + E Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 72 SLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 +R P +V T T L +I++Y +GGEL+ + RF+E E + + +++ + Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEV 188 + H + I +RD+KLEN LLD + + + DFG SK V + GT Y+AP++ Sbjct: 174 HLHKLGIIYRDIKLENILLDSN--GHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDI 231 Query: 189 LLRQEY-DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 + + K D WS GV +Y +L GA PF E + +RIL + P + + Sbjct: 232 VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE--M 289 Query: 248 SPECCHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 S LI R+ + DP R+ EIK H +F K DL + P +P Sbjct: 290 SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDL-----AAKKVPAPFKP 344 Query: 303 M 303 + Sbjct: 345 V 345 >2X4F-A nrPDB Length = 373 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 80/257 (31%), Positives = 129/257 (50%), Gaps = 9/257 (3%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEV 84 + +G G FG + T +A K I+ RG K E V+ EI L H N+++ + Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 85 ILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + + ++MEY GGEL++RI + +E + F +Q+ G+ + H M I H DLK Sbjct: 155 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK 214 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 EN L A ++KI DFG ++ + K GTP ++APEV+ ++ D+WS Sbjct: 215 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNY-DFVSFPTDMWS 273 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECCHLISRIFVA 261 GV Y++L G PF + +T+ IL+ ++ + D+ IS E IS++ + Sbjct: 274 VGVIAYMLLSGLSPFLGDNDA----ETLNNILACRWDLEDEEFQDISEEAKEFISKLLIK 329 Query: 262 DPATRISIPEIKTHSWF 278 + + RIS E H W Sbjct: 330 EKSWRISASEALKHPWL 346 >3NIZ-A nrPDB Length = 311 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 127/307 (41%), Gaps = 33/307 (10%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENV 63 ++G ++ ++Y ++ +G G +GV +D +VA+K I + I Sbjct: 8 SSGRENLYFQGLMEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTA 66 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFF 122 REI + L HPNIV +VI + L ++ E+ +L + + N + + + + Sbjct: 67 IREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYL 125 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTP 181 QLL GV++CH +I HRDLK +N L++ A LK+ DFG +++ + V T Sbjct: 126 YQLLRGVAHCHQHRILHRDLKPQNLLINSDGA--LKLADFGLARAFGIPVRSYTHEVVTL 183 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK--- 238 Y AP+VL+ + D+WS G M+ G F + K + + Sbjct: 184 WYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPRE 243 Query: 239 -----------------YSIPDDIRISP----ECCHLISRIFVADPATRISIPEIKTHSW 277 + I P E L+S + DP RIS + H + Sbjct: 244 WPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPY 303 Query: 278 FLKNLPA 284 F P Sbjct: 304 FKDLDPQ 310 >2HW6-A nrPDB Length = 307 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 119/306 (38%), Gaps = 29/306 (9%) Query: 9 GPLDMPIMHDSDRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERG-DKIDENVQRE 66 G D D Y + +G G + + + AVK IE+ V RE Sbjct: 1 GSTDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFRE 60 Query: 67 IINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 + + + NI+ E T ++ E GG + I F+E EA + + Sbjct: 61 VETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDV 120 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHS--------QPKS 176 + + + H+ I HRDLK EN L + +KICDF L++ + + Sbjct: 121 AAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTT 180 Query: 177 TVGTPAYIAPEVLL----RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPR------- 225 G+ Y+APEV+ + + K D+WS GV LY+ML G PF Sbjct: 181 PCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGE 240 Query: 226 ----DYRKTIQRILSVKYSIP--DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 K + I KY P D IS E LIS++ V D R+S ++ H W Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 280 KNLPAD 285 P Sbjct: 301 GQAPEK 306 >4LG4-A nrPDB Length = 299 Score = 263 bits (673), Expect = 9e-71, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 126/290 (43%), Gaps = 17/290 (5%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 D + +D ++ +G G++G K + ++VA+K + + E + +EI + Sbjct: 3 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-IIKEISIMQ 61 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVS 130 P +V++ T L I+MEY G + + I EDE + L G+ Sbjct: 62 QCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 121 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 189 Y H M+ HR++K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 122 YLHFMRKIHRNIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 179 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR--- 246 Y+ +AD+WS G+T M G P+ D ++ I + + P R Sbjct: 180 QEIGYNC-VADIWSLGITSIEMAEGKPPYADIHP-------MRAIFMIPTNPPPTFRKPE 231 Query: 247 -ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQ 295 S + + + V +P R + ++ H + P ++ + T + Sbjct: 232 LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAM 281 >5FET-A nrPDB Length = 847 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 90/341 (26%), Positives = 149/341 (43%), Gaps = 37/341 (10%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----RHP 76 + + IG G FG +L+ K T+ A+K + + I N Q I R + HP Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHP 593 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + E +GGELY+ I G S+ +A+F+ ++ + Y H Sbjct: 594 FIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERN 653 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I +RDLK EN LLD +K+ DFG +K + + + VGTP Y+APEV+L + Y G Sbjct: 654 IVYRDLKPENILLD--KQGYVKLIDFGCAKK--IQGRAYTLVGTPHYMAPEVILGKGY-G 708 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D+W+ GV LY + G PF + +E D + + IL+ + + PD + + +L+ Sbjct: 709 CTVDIWALGVCLYEFICGPLPFGNDQE--DQLEIFRDILTGQLTFPDYVS-DQDSINLMK 765 Query: 257 RIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQ 311 R+ P RI +IK H++F + + G + P Sbjct: 766 RLLCRLPQGRIGCSINGFKDIKEHAFF-----GNFNWDKLAGRLLEPP------------ 808 Query: 312 IISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDID 352 + +D + D ++ + D + D+D Sbjct: 809 ---LVSKGETYAEDIDIKQIEEEDALNEGEPLDGDDSWDVD 846 >5DYK-A nrPDB Length = 853 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 88/297 (29%), Positives = 139/297 (46%), Gaps = 17/297 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----RH 75 D + + IG G FG +L+ K TK A+K + + I+ N Q I R + H Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P I+R + + E +GGELY+ I G S+ +A+F+ ++ + Y H Sbjct: 599 PFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHER 658 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I +RDLK EN LLD +K+ DFG +K + + + VGTP Y+APEV+L + Y Sbjct: 659 NIVYRDLKPENILLD--KQGYVKLIDFGCAKK--VQGRAYTLVGTPHYMAPEVILGKGY- 713 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 G D+W+ G+ LY + G PF + EE D + + IL+ + + PD + + +L+ Sbjct: 714 GCTVDIWALGICLYEFICGPLPFGNDEE--DQLEIFRDILTGQLTFPDYVT-DTDSINLM 770 Query: 256 SRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLD 307 R+ P RI +IK H +F L + E + +D Sbjct: 771 KRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDID 827 >4JXF-A nrPDB Length = 266 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 78/268 (29%), Positives = 130/268 (48%), Gaps = 15/268 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRH 75 + + +G G+F T VA+K I++ + VQ E+ H L+H Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHS 134 P+I+ ++ +++E GE+ + N FSE+EAR F Q+++G+ Y HS Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 126 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQE 193 I HRDL L N LL + +KI DFG + + H + + GTP YI+PE + + Sbjct: 127 HGILHRDLTLSNLLLTRNM--NIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRS 183 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 G +DVWS G Y +L+G PF+ + T+ +++ Y +P + I E Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTD----TVKNTLNKVVLADYEMPSFLSI--EAKD 237 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKN 281 LI ++ +PA R+S+ + H + +N Sbjct: 238 LIHQLLRRNPADRLSLSSVLDHPFMSRN 265 >4I6B-A nrPDB Length = 308 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 82/277 (29%), Positives = 138/277 (49%), Gaps = 14/277 (5%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE----RGDKIDENVQREIINHRSLR 74 RY K +G G F M D ++ A K I E + +EI HR L Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH 86 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H ++V+F ++ I++EY S + + +E E R++ +Q++SG+ Y H Sbjct: 87 HKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHE 146 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 +I HRDLKL N ++ S LK+ DFG ++ L + ++ GTP Y++PEVL +Q Sbjct: 147 QEILHRDLKLGNFFINESM--ELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG 204 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 + G +D+W+ G +Y ML+G PF E + ++T + I +Y++P + H Sbjct: 205 H-GAESDIWALGCVMYTMLLGRPPF----ETTNLKETYRSIREARYTMPSSLLAP--AKH 257 Query: 254 LISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 LI+ + +P R S+ +I H +F + D ++ S Sbjct: 258 LIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSS 294 >1NY3-A nrPDB Length = 400 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 94/317 (29%), Positives = 151/317 (47%), Gaps = 18/317 (5%) Query: 20 DRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHPN 77 D Y + +G G G + +K T+E A+K ++ K +RE+ H R+ + P+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 116 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 IVR +V L I+ME GGEL+ RI + G F+E EA + + + Y Sbjct: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 132 CHSMQICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS+ I HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRIS 248 ++YD K D+WS GV +Y++L G PF KT R+ ++ P+ +S Sbjct: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 E LI + +P R++I E H W +++ +T +E ++ + + Sbjct: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ-TPLHTSRVLKEDKERWEDVKE 354 Query: 309 IMQIISEATIPAVRNRC 325 M + AT+ + Sbjct: 355 EM-TSALATMRVDYEQI 370 >5YV8-A nrPDB Length = 298 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 94/293 (32%), Positives = 140/293 (47%), Gaps = 39/293 (13%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID------------------- 60 ++Y +IG G++GV +L ++ A+K + + I Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 61 --------ENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNA 110 E V +EI + L HPN+V+ EV+ P HL ++ E + G + E + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 131 Query: 111 GRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV- 169 SED+ARF+FQ L+ G+ Y H +I HRD+K N L+ +KI DFG S Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGED--GHIKIADFGVSNEFKG 189 Query: 170 LHSQPKSTVGTPAYIAPEVLL--RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 + +TVGTPA++APE L R+ + GK DVW+ GVTLY + G PF D Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----ERI 245 Query: 228 RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 +I S PD I+ + LI+R+ +P +RI +PEIK H W + Sbjct: 246 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >3ORZ-A nrPDB Length = 316 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 84/285 (29%), Positives = 130/285 (45%), Gaps = 22/285 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRH 75 + + F K +G G+F L R+ T A+K +E+ I EN V RE L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P V+ L + YA GEL + I G F E RF+ +++S + Y H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLRQ 192 I HRDLK EN LL+ ++I DFG +K S+ S VGT Y++PE LL + Sbjct: 157 GIIHRDLKPENILLNEDM--HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTE 213 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 + K +D+W+ G +Y ++ G PF E Q+I+ ++Y P+ P+ Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYL----IFQKIIKLEYDFPEKFF--PKAR 267 Query: 253 HLISRIFVADPATRISIPE------IKTHSWFLKNLPADLMNESN 291 L+ ++ V D R+ E +K H +F +L ++ Sbjct: 268 DLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP 312 >4B6L-A nrPDB Length = 281 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 92/272 (33%), Positives = 129/272 (47%), Gaps = 14/272 (5%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPN 77 Y + +G G F D T AVK I + E + EI HR L+H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 IVRF ++ I +E S L E E R++ +Q+LSG+ Y H I Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRDLKL N + + LK+ DFG ++ + K+ GTP Y+APEVLLRQ + G Sbjct: 131 LHRDLKLGNFFITENM--ELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-G 187 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 ADVWS G +Y +L G+ PF E D ++T + I V Y++P +S L++ Sbjct: 188 PEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIKQVHYTLP--ASLSLPARQLLA 241 Query: 257 RIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 I A P R SI +I H +F K D + Sbjct: 242 AILRASPRDRPSIDQILRHDFFTKGYTPDRLP 273 >2OZA-A nrPDB Length = 356 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 94/317 (29%), Positives = 151/317 (47%), Gaps = 18/317 (5%) Query: 20 DRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHPN 77 D Y + +G G G + +K T+E A+K ++ K +RE+ H R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 72 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 IVR +V L I+ME GGEL+ RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 132 CHSMQICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS+ I HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRIS 248 ++YD K D+WS GV +Y++L G PF KT R+ ++ P+ +S Sbjct: 193 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 251 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 E LI + +P R++I E H W +++ +T +E ++ + + Sbjct: 252 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ-TPLHTSRVLKEDKERWEDVKE 310 Query: 309 IMQIISEATIPAVRNRC 325 M + AT+ + Sbjct: 311 EM-TSALATMRVDYEQI 326 >4RA4-A nrPDB Length = 355 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 89/330 (26%), Positives = 146/330 (44%), Gaps = 27/330 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLRHP 76 ++F+ +G G+FG L K T+EL A+K +++ D E E L P Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 77 -NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 + + T L +MEY +GG+L I G+F E +A F+ ++ G+ + H Sbjct: 81 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 140 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEY 194 I +RDLKL+N +LD +KI DFG K ++ ++ GTP YIAPE++ Q Y Sbjct: 141 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 198 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 GK D W+ GV LY ML G PF+ +E ++ ++ +S S +S E + Sbjct: 199 -GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKS------LSKEAVSI 251 Query: 255 ISRIFVADPATRISI-----PEIKTHSWFLKNLPADLMNES-NTGSQFQEPEQPMQSLDT 308 + PA R+ +++ H++F + L N + + + ++ D Sbjct: 252 CKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAENFDK 311 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNLDLDD 338 P D + N+D D Sbjct: 312 FFTRGQPVLTPP------DQLVIANIDQSD 335 >3KA0-A nrPDB Length = 320 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 94/310 (30%), Positives = 149/310 (48%), Gaps = 18/310 (5%) Query: 20 DRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHPN 77 D Y + +G G G + +K T+E A+K ++ K +RE+ H R+ + P+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 70 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 IVR +V L I+ME GGEL+ RI + G F+E EA + + + Y Sbjct: 71 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 132 CHSMQICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS+ I HRD+K EN L P LK+ DFG++K + H+ TP Y+APEVL Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLG 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRIS 248 ++YD K D+WS GV +Y++L G PF KT R+ ++ P+ +S Sbjct: 191 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 249 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 E LI + +P R++I E H W +++ +T +E ++ + + Sbjct: 250 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ-TPLHTSRVLKEDKERWEDVKE 308 Query: 309 IMQIISEATI 318 M + AT+ Sbjct: 309 EM-TSALATM 317 >6AO5-A nrPDB Length = 362 Score = 260 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 126/290 (43%), Gaps = 17/290 (5%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 D + +D ++ +G G++G K + ++VA+K + + E + +EI + Sbjct: 2 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-IIKEISIMQ 60 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVS 130 P +V++ T L I+MEY G + + I EDE + L G+ Sbjct: 61 QCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 120 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVL 189 Y H M+ HR++K N LL+ K+ DFG + ++ + +GTP ++APEV+ Sbjct: 121 YLHFMRKIHRNIKAGNILLNTE--GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 178 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR--- 246 Y+ +AD+WS G+T M G P+ D ++ I + + P R Sbjct: 179 QEIGYNC-VADIWSLGITSIEMAEGKPPYADIHP-------MRAIFMIPTNPPPTFRKPE 230 Query: 247 -ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQ 295 S + + + V +P R + ++ H + P ++ + T + Sbjct: 231 LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAM 280 >6ED6-A nrPDB Length = 415 Score = 260 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 87/295 (29%), Positives = 129/295 (43%), Gaps = 19/295 (6%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHR 71 ++ YD VK IG G FG +L+R K ++++ A+K + + + I + E Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 P +V+ +L ++MEY GG+L + N E A+F+ +++ + Sbjct: 144 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDA 202 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVL 189 HSM + HRD+K +N LLD LK+ DFG + VGTP YI+PEVL Sbjct: 203 IHSMGLIHRDVKPDNMLLDKH--GHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 260 Query: 190 L---RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 + G+ D WS GV LY MLVG PF Y K + P+D Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDH--KNSLCFPEDAE 318 Query: 247 ISPECCHLISRIFVADPATRI---SIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 IS +LI D R+ + EI+ H +F KN N T + Sbjct: 319 ISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFF-KNDQWHWDNIRETAAPVVP 371 >4QMW-A nrPDB Length = 310 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 128/286 (44%), Gaps = 14/286 (4%) Query: 1 MDRAPVTTG-PLDMPIMHDSDR-YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RG 56 M +PV +G P + D + + ++ IG G+FG D T+++VA+K I+ Sbjct: 8 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 67 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSED 116 + E++Q+EI P + ++ L T L IIMEY GG + + G E Sbjct: 68 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDET 126 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPK 175 + +++L G+ Y HS + HRD+K N LL +K+ DFG + + Sbjct: 127 QIATILREILKGLDYLHSEKKIHRDIKAANVLLSEH--GEVKLADFGVAGQLTDTQIKRN 184 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 + VGTP ++APEV+ + YD K AD+WS G+T + G P K + I Sbjct: 185 TFVGTPFWMAPEVIKQSAYDSK-ADIWSLGITAIELARGEPP----HSELHPMKVLFLIP 239 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 + S + +P+ R + E+ H + L+N Sbjct: 240 KNNPPT-LEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 284 >4EWQ-A nrPDB Length = 383 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 129/335 (38%), Gaps = 43/335 (12%) Query: 2 DRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-- 59 +R L+ I +RY + +GSG +G D T VAVK + R + Sbjct: 27 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSII 86 Query: 60 -DENVQREIINHRSLRHPNIVRFKEVI------LTPTHLAIIMEYASGGELYERICNAGR 112 + RE+ + ++H N++ +V + ++ G +L I + Sbjct: 87 HAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADL-NNIVKCQK 144 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 ++D +F Q+L G+ Y HS I HRDLK N ++ LKI DFG ++ + Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHT--DD 200 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 + V T Y APE++L + + D+WS G + +L G F + + ++ Sbjct: 201 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 260 Query: 233 RILSVKYS-------------------IPD------DIRISPECCHLISRIFVADPATRI 267 + + +P I +P L+ ++ V D RI Sbjct: 261 LVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI 320 Query: 268 SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 + + H++F + D + + + + Sbjct: 321 TAAQALAHAYFAQYHDPD---DEPVADPYDQSFES 352 >3DB8-A nrPDB Length = 317 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 91/284 (32%), Positives = 134/284 (47%), Gaps = 14/284 (4%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKI 59 AP+ P + RY + +G G F + D TKE+ A K + + Sbjct: 26 APLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQ 85 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR 119 E + EI H+SL +P++V F + +++E L E +E EAR Sbjct: 86 KEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEAR 145 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTV 178 +F +Q + GV Y H+ ++ HRDLKL N L+ +KI DFG + + K Sbjct: 146 YFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDM--DVKIGDFGLATKIEFDGERKKDLC 203 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GTP YIAPEVL ++ + + D+WS G LY +LVG PFE ++T RI + Sbjct: 204 GTPNYIAPEVLCKKGHSFE-VDIWSLGCILYTLLVGKPPFETS----CLKETYIRIKKNE 258 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 YS+P I+P LI R+ ADP R S+ E+ T +F Sbjct: 259 YSVPR--HINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGY 300 >2BRG-A nrPDB Length = 297 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 96/285 (33%), Positives = 150/285 (52%), Gaps = 10/285 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPN 77 + +D V+ +G G +G +L +++T+E VAVK ++ +D EN+++EI ++ L H N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V+F + +EY SGGEL++RI E +A+ FF QL++GV Y H + I Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLRQEY 194 HRD+K EN LLD LKI DFG + +++ + GT Y+APE+L R+E+ Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 + DVWSCG+ L ML G P+ ++P D + K + +I L Sbjct: 185 HAEPVDVWSCGIVLTAMLAGELPW---DQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL 241 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 + +I V +P+ RI+IP+IK W+ K L T E Sbjct: 242 LHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSES 286 >5J5T-A nrPDB Length = 370 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 77/287 (26%), Positives = 130/287 (45%), Gaps = 9/287 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPNI 78 + ++ ++ IGSG +G R+ T EL A+K I+ D VQ+EII + +HPNI Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNI 63 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V + L L I ME+ GG L + G SE + + ++ L G+ Y HS Sbjct: 64 VAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKM 123 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEV--LLRQEYD 195 HRD+K N LL + +K+ DFG S ++ K+ +GTP ++APEV + R+ Sbjct: 124 HRDIKGANILLTDN--GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGY 181 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 ++ D+W+ G+T + P D R + + + D ++ S H + Sbjct: 182 NQLCDLWAVGITAIELAELQPPMFDLHPMRA-LFLMTKSNFQPPKLKDKMKWSNSFHHFV 240 Query: 256 SRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 +P R + ++ H + ++L L E + P+ Sbjct: 241 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIE--LLDKVNNPDHS 285 >6FD3-A nrPDB Length = 300 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 128/285 (44%), Gaps = 9/285 (3%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHR 71 + + +Y + IG G G D T + VA+K + + + + EI+ R Sbjct: 15 VSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMR 74 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 ++PNIV + + L L ++MEY +GG L + + E + ++ L + + Sbjct: 75 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDF 133 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLL 190 HS Q+ HRD+K +N LL + +K+ DFG+ +ST VGTP ++APEV+ Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT 191 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 R+ Y G D+WS G+ M+ G P+ + E P I + + P+ R+S Sbjct: 192 RKAY-GPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPE--RLSAV 247 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQ 295 ++R D R S E+ H + + P + ++ Sbjct: 248 FRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKPLSSLTPLIIAAK 292 >3TXO-A nrPDB Length = 353 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 87/300 (29%), Positives = 134/300 (44%), Gaps = 22/300 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG----DKIDENVQREIINHRSLR- 74 D ++F++ +G G+FG L R K T +L AVK +++ D E E R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HP + + TP L +ME+ +GG+L I + RF E ARF+ +++S + + H Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 142 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLLRQE 193 I +RDLKL+N LLD K+ DFG K + + + GTP YIAPE+L Sbjct: 143 KGIIYRDLKLDNVLLDHE--GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y G D W+ GV LY ML G PFE E + IL+ + P + + Sbjct: 201 Y-GPAVDWWAMGVLLYEMLCGHAPFEAENEDD----LFEAILNDEVVYPTWLH--EDATG 253 Query: 254 LISRIFVADPATRISI------PEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLD 307 ++ +P R+ I H +F + A +N F+ + + + Sbjct: 254 ILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWA-QLNHRQIEPPFRPRIKSREDVS 312 >4CSV-A nrPDB Length = 275 Score = 257 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 106/271 (39%), Gaps = 16/271 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREII 68 GP D + +GSG FG + + VAVK ++ G E +E Sbjct: 1 GPHD-KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQ 59 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQLL 126 + L+HPN+V+ V + II EY S G L + + C + Q+ Sbjct: 60 IMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVA 119 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AY 183 SG++Y S HRDL N L+ + +K+ DFG ++ + + + G + Sbjct: 120 SGMAYLESQNFIHRDLAARNCLVGENNV--VKVADFGLAR-LINEDEYTARAGAKFPIKW 176 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 APE + + K +DVW+ G+ L+ + G P+ + + Y +P Sbjct: 177 TAPEAISYNRFSIK-SDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQ-----VERGYRMP 230 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIK 273 E L+ + + P R + E Sbjct: 231 RPQGCPEEIYELMLQCWNKSPEERPTFAETL 261 >3OHT-A nrPDB Length = 389 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 76/350 (21%), Positives = 132/350 (37%), Gaps = 42/350 (12%) Query: 2 DRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-- 59 +R L+ I +RY + +GSG +G D + +AVK + R + Sbjct: 33 ERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSII 92 Query: 60 -DENVQREIINHRSLRHPNIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGR 112 + RE+ + ++H N++ +V T L ++ G +L I + Sbjct: 93 HAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADL-NNIVKCQK 150 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 ++D +F Q+L G+ Y HS I HRDLK N ++ LKI DFG ++ + Sbjct: 151 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHT--DD 206 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 + V T Y APE++L + D+WS G + +L G F + ++ ++ Sbjct: 207 EMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR 266 Query: 233 RILSVK-------------------YSIPDDIRIS------PECCHLISRIFVADPATRI 267 + +P P L+ ++ V D RI Sbjct: 267 LTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRI 326 Query: 268 SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEAT 317 + E H +F + D ES Q E Q ++ ++ E Sbjct: 327 TASEALAHPYFSQYHDPDDEPESEPYDQSFESRQL--EIEEWKRLTYEEV 374 >4AGU-A nrPDB Length = 311 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 115/288 (39%), Gaps = 31/288 (10%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK---IDENVQREIINHRSLRHP 76 ++Y+ + IG G++GV R++ T ++VA+K + I + REI + L+HP Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 N+V EV L ++ EY L+E E + Q L V++CH Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHN 122 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYIAPEVLLRQEYD 195 HRD+K EN L+ + +K+CDFG+++ V T Y +PE+L+ Sbjct: 123 CIHRDVKPENILI--TKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI-----------------QRILSVK 238 G DVW+ G +L G + + Q VK Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 239 YSIPDD--------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 P+D IS L+ DP R++ ++ H +F Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >4B8L-A nrPDB Length = 286 Score = 255 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 84/266 (31%), Positives = 131/266 (49%), Gaps = 14/266 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE----NVQREIINHRSLRH 75 D +D + +G G FG L R+K K ++A+K + + E ++REI LRH Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 PNI+R + +++E+A GELY+ + GRF E + F ++L + YCH Sbjct: 75 PNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHER 134 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 ++ HRD+K EN L+ LKI DFG+S + ++ GT Y+ PE++ + +D Sbjct: 135 KVIHRDIKPENLLMGYK--GELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMIEGKTHD 191 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K D+W GV Y LVG PF+ P +R RI++V P +S LI Sbjct: 192 EK-VDLWCAGVLCYEFLVGMPPFDSPSHTETHR----RIVNVDLKFPPF--LSDGSKDLI 244 Query: 256 SRIFVADPATRISIPEIKTHSWFLKN 281 S++ P R+ + + H W N Sbjct: 245 SKLLRYHPPQRLPLKGVMEHPWVKAN 270 >6GU6-A nrPDB Length = 302 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 123/289 (42%), Gaps = 33/289 (11%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHRSLRHP 76 + Y ++ IG G +GV R K T ++VA+K I + + REI + LRHP Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICN---AGRFSEDEARFFFQQLLSGVSYCH 133 NIV ++V++ + L +I E+ S +L + + + + + Q+L G+ +CH Sbjct: 67 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQ 192 S ++ HRDLK +N L+D +K+ DFG +++ + V T Y +PEVLL Sbjct: 126 SRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 183 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT--------------IQRILSVK 238 D+WS G + F E + ++ + K Sbjct: 184 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 243 Query: 239 YSIPDD---------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 + P + L+S++ + DPA RIS H +F Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >6DTL-A nrPDB Length = 364 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 80/324 (24%), Positives = 121/324 (37%), Gaps = 35/324 (10%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRHPNIVRF 81 + IG G +G+ + T E VA+K I + REI R + H NIV Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 82 KEVILTP-----THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +++I P + I E +L++ I + SE+ ++F Q+L G+ Y HS Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + HRDLK N LL+ + LKICDFG ++ + V T Y APE+LL Sbjct: 154 VLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY---------------SI 241 DVWS G ++ F + R ++ I + + Sbjct: 212 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271 Query: 242 PDDIRIS---------PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNT 292 P R S P LI ++ DP RI++ + H + E Sbjct: 272 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTI 331 Query: 293 GSQFQEPEQPMQSLDTIMQIISEA 316 F + I EA Sbjct: 332 PFNFDFENHALSEEQMKELIYREA 355 >5F9E-A nrPDB Length = 353 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 86/290 (29%), Positives = 141/290 (48%), Gaps = 17/290 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK-IDENVQREIINHRSLR---- 74 + ++ K +G G+FG L K T + A+K +++ +D++V+ ++ R L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 HP + T +L +MEY +GG+L I + +F A F+ +++ G+ + HS Sbjct: 79 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHS 138 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-HSQPKSTVGTPAYIAPEVLLRQE 193 I +RDLKL+N LLD +KI DFG K ++L ++ GTP YIAPE+LL Q+ Sbjct: 139 KGIVYRDLKLDNILLDKD--GHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Y+ D WS GV LY ML+G PF +D + I P + E Sbjct: 197 YNH-SVDWWSFGVLLYEMLIGQSPFHG----QDEEELFHSIRMDNPFYPRWLE--KEAKD 249 Query: 254 LISRIFVADPATRISIP-EIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 L+ ++FV +P R+ + +I+ H F + +L F+ + Sbjct: 250 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEEL-ERKEIDPPFRPKVKS 298 >2OU7-A nrPDB Length = 335 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 83/260 (31%), Positives = 122/260 (46%), Gaps = 14/260 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPNIVRFKE 83 +G G F + D TKE+ A K + + E + EI HRSL H ++V F Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + +++E L E +E EAR++ +Q++ G Y H ++ HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLRQEYDGKIADVW 202 L N L+ +KI DFG + + K GTP YIAPEVL ++ + + DVW Sbjct: 169 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VDVW 225 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G +Y +LVG PFE ++T RI +YSIP I+P LI ++ D Sbjct: 226 SIGCIMYTLLVGKPPFETS----CLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 279 Query: 263 PATRISIPEIKTHSWFLKNL 282 P R +I E+ +F Sbjct: 280 PTARPTINELLNDEFFTSGY 299 >4FIE-A nrPDB Length = 423 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 13/272 (4%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 217 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD+K + Sbjct: 218 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 276 Query: 146 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G D+WS Sbjct: 277 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 333 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + + + + + + ++SP + R+ V DPA Sbjct: 334 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNL---PPRLKNLHKVSPSLKGFLDRLLVRDPA 390 Query: 265 TRISIPEIKTHSWFLKNLPA----DLMNESNT 292 R + E+ H + K P LM ++ T Sbjct: 391 QRATAAELLKHPFLAKAGPPASIVPLMRQNRT 422 >4AU8-A nrPDB Length = 296 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 73/295 (24%), Positives = 126/295 (42%), Gaps = 32/295 (10%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRH 75 S +Y+ ++ IG G +G +++ T E+VA+K + D + + REI + L+H Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHS 134 NIVR +V+ + L ++ E+ +L + + G + + F QLL G+ +CHS Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQE 193 + HRDLK +N L++ + LK+ DFG +++ + + V T Y P+VL + Sbjct: 124 RNVLHRDLKPQNLLINRN--GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS--------IPDD- 244 D+WS G + P + D K I R+L +PD Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 245 ---------------IRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 +++ L+ + +P RIS E H +F P Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >3FXW-A nrPDB Length = 336 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 142/319 (44%), Gaps = 19/319 (5%) Query: 18 DSDRYDFVK-DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH- 75 +D Y K +G G G + T + A+K + K ++E+ +H Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK----ARQEVDHHWQASGG 81 Query: 76 PNIVRFKEVILT----PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGV 129 P+IV +V L IIME GGEL+ RI G F+E EA + + + + Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 141 Query: 130 SYCHSMQICHRDLKLENTLLDGSPA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 + HS I HRD+K EN L LK+ DFG++K + ++ ++ TP Y+APEV Sbjct: 142 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA-LQTPCYTPYYVAPEV 200 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDP--EEPRDYRKTIQRILSVKYSIPDDIR 246 L ++YD K D+WS GV +Y++L G PF + K R+ + P+ Sbjct: 201 LGPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSE 259 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSL 306 +S + LI + DP R++I + H W +++ +T QE + + Sbjct: 260 VSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQ-TPLHTARVLQEDKDHWDEV 318 Query: 307 DTIMQIISEATIPAVRNRC 325 M + AT+ ++ Sbjct: 319 KEEM-TSALATMRVDYDQV 336 >3DAK-A nrPDB Length = 290 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 119/289 (41%), Gaps = 22/289 (7%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIIN 69 +P + D Y+ + IGSG V + KE VA+K I E+ + + +EI Sbjct: 2 ALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQA 61 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--------CNAGRFSEDEARFF 121 HPNIV + + L ++M+ SGG + + I +G E Sbjct: 62 MSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ------PK 175 +++L G+ Y H HRD+K N LL + ++I DFG S K Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGS--VQIADFGVSAFLATGGDITRNKVRK 179 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR-- 233 + VGTP ++APEV+ + AD+WS G+T + GA P+ + T+Q Sbjct: 180 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 239 Query: 234 --ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 + + + +IS DP R + E+ H +F K Sbjct: 240 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >4KRC-A nrPDB Length = 317 Score = 253 bits (647), Expect = 9e-68, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 130/314 (41%), Gaps = 40/314 (12%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK--YIERGDKIDENVQREIINHRSL 73 M S ++ ++ +G+G + +K T VA+K ++ + REI + L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA------GRFSEDEARFFFQQLLS 127 +H NIVR +VI T L ++ E+ +L + + + + ++F QLL Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAP 186 G+++CH +I HRDLK +N L+ + +LK+ DFG +++ + + S V T Y AP Sbjct: 120 GLAFCHENKILHRDLKPQNLLI--NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL----------- 235 +VL+ D+WSCG L M+ G F + + + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 236 -------SVKYSIPDDIR----------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 +++ P D+R + + + +P R+S + H WF Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Query: 279 LKNLPADLMNESNT 292 + M S + Sbjct: 298 AEYYHHASMGGSRS 311 >1CM8-A nrPDB Length = 367 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 119/311 (38%), Gaps = 40/311 (12%) Query: 2 DRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDK 58 R+ + Y ++ +GSG +G D T VA+K + R + Sbjct: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Query: 59 IDENVQREIINHRSLRHPNIVRFKEVILTP------THLAIIMEYASGGELYERICNAGR 112 + RE+ + +RH N++ +V T ++M + G ++ + Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEK 124 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 ED +F Q+L G+ Y H+ I HRDLK N ++ LKI DFG ++ + S Sbjct: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DS 180 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 + V T Y APEV+L + D+WS G + M+ G F+ + ++ ++ Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 233 RILSVKYSIPDDI-------------------------RISPECCHLISRIFVADPATRI 267 + + SP +L+ ++ V D R+ Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 268 SIPEIKTHSWF 278 + E H +F Sbjct: 301 TAGEALAHPYF 311 >4J52-A nrPDB Length = 293 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 83/260 (31%), Positives = 122/260 (46%), Gaps = 14/260 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPNIVRFKE 83 +G G F + D TKE+ A K + + E + EI HRSL H ++V F Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 + +++E L E +E EAR++ +Q++ G Y H ++ HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLRQEYDGKIADVW 202 L N L+ +KI DFG + + K GTP YIAPEVL ++ + + DVW Sbjct: 142 LGNLFLNED--LEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFE-VDVW 198 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G +Y +LVG PFE ++T RI +YSIP I+P LI ++ D Sbjct: 199 SIGCIMYTLLVGKPPFETS----CLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTD 252 Query: 263 PATRISIPEIKTHSWFLKNL 282 P R +I E+ +F Sbjct: 253 PTARPTINELLNDEFFTSGY 272 >6CKI-A nrPDB Length = 316 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 120/309 (38%), Gaps = 29/309 (9%) Query: 9 GPLDMPIMHDSDRYDFVK-DIGSGNFGVARLMRDKLTKELVAVKYIERGD-KIDENVQRE 66 G D D Y + +G G + + +T + AVK IE+ I V RE Sbjct: 1 GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFRE 60 Query: 67 IINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 + + H N++ E ++ E GG + I F+E EA Q + Sbjct: 61 VEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDV 120 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHSQPK--------S 176 S + + H+ I HRDLK EN L + + +KICDFG L+ + Sbjct: 121 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLT 180 Query: 177 TVGTPAYIAPEVL----LRQEYDGKIADVWSCGVTLYVMLVGAYPF-----------EDP 221 G+ Y+APEV+ K D+WS GV LY++L G PF Sbjct: 181 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 240 Query: 222 EEPRDYRKTIQRILSVKYSIP--DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 P + I KY P D IS LIS++ V D R+S ++ H W Sbjct: 241 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 280 KNLPADLMN 288 P + + Sbjct: 301 GCAPENTLP 309 >4JDH-A nrPDB Length = 346 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 13/272 (4%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 140 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD+K + Sbjct: 141 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 199 Query: 146 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G D+WS Sbjct: 200 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 256 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + + + + + + ++SP + R+ V DPA Sbjct: 257 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNL---PPRLKNLHKVSPSLKGFLDRLLVRDPA 313 Query: 265 TRISIPEIKTHSWFLKNLPA----DLMNESNT 292 R + E+ H + K P LM ++ T Sbjct: 314 QRATAAELLKHPFLAKAGPPASIVPLMRQNRT 345 >1UA2-A nrPDB Length = 346 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 132/329 (40%), Gaps = 41/329 (12%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG------DKIDENVQ 64 + + + + RY+ + +G G F RDK T ++VA+K I+ G D I+ Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQ 123 REI + L HPNI+ + ++++++ ++ +L I N+ + + + Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML 119 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPA 182 L G+ Y H I HRDLK N LLD + LK+ DFG +KS + V T Sbjct: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRW 177 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--- 239 Y APE+L G D+W+ G L +L+ PF + D I L Sbjct: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 Query: 240 -----SIPDDIRISP---------------ECCHLISRIFVADPATRISIPEIKTHSWFL 279 S+PD + + LI +F+ +P RI+ + +F Sbjct: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF- 295 Query: 280 KNLPADLMNESNTGSQFQEPEQPMQSLDT 308 G Q P P+++L Sbjct: 296 -----SNRPGPTPGCQLPRPNCPVETLKE 319 >3GC9-A nrPDB Length = 370 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 74/353 (20%), Positives = 139/353 (39%), Gaps = 46/353 (13%) Query: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI--- 59 RA L+ + R ++ +GSG +G D ++ VAVK + R + Sbjct: 11 RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH 70 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPT------HLAIIMEYASGGELYERICNAGRF 113 RE+ + L+H N++ +V T + ++ G +L I + Sbjct: 71 ARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADL-NNIVKSQAL 128 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 S++ +F QLL G+ Y HS I HRDLK N ++ L+I DFG ++ + + Sbjct: 129 SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--SELRILDFGLARQA--DEE 184 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 V T Y APE++L + + D+WS G + +L G F + ++ ++ Sbjct: 185 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 244 Query: 234 ILSVKYS-------------------IPDDIRIS------PECCHLISRIFVADPATRIS 268 + + +P S P L+ R+ V D R+S Sbjct: 245 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 304 Query: 269 IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAV 321 E H++F + ++ + + ++ +++ + ++ E T V Sbjct: 305 AAEALAHAYFSQ------YHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEV 351 >2Q0N-A nrPDB Length = 301 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 13/272 (4%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 95 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD+K + Sbjct: 96 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 154 Query: 146 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G D+WS Sbjct: 155 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 211 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + + + + + + ++SP + R+ V DPA Sbjct: 212 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNL---PPRLKNLHKVSPSLKGFLDRLLVRDPA 268 Query: 265 TRISIPEIKTHSWFLKNLPA----DLMNESNT 292 R + E+ H + K P LM ++ T Sbjct: 269 QRATAAELLKHPFLAKAGPPASIVPLMRQNRT 300 >3PFQ-A nrPDB Length = 674 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 90/293 (30%), Positives = 141/293 (48%), Gaps = 25/293 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RH 75 ++F+ +G G+FG L K T EL AVK +++ I D++V+ ++ R L + Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 401 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 402 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 461 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEY 194 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Y Sbjct: 462 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 519 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 GK D W+ GV LY ML G PFE +E ++ ++ ++ S+ S E + Sbjct: 520 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM------SKEAVAI 572 Query: 255 ISRIFVADPATRISI-----PEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 + P R+ +IK H++F + E + Q P +P Sbjct: 573 CKGLMTKHPGKRLGCGPEGERDIKEHAFFR-----YIDWEKLERKEIQPPYKP 620 >3LM0-A nrPDB Length = 327 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 14/322 (4%) Query: 4 APVTTGPLDMPI--MHDSDRYDFV--KDIGSGNFGVARLMRDKLTKELVAVKYIER---G 56 + V G ++ M + + + + K++G G F V R K T + A K++++ G Sbjct: 9 SGVDLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRG 68 Query: 57 DKIDENVQREIINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRF 113 + EI + P ++ EV + + +I+EYA+GGE++ A Sbjct: 69 QDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMV 128 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDG-SPAPRLKICDFGYSKSSVLHS 172 SE++ +Q+L GV Y H I H DLK +N LL P +KI DFG S+ Sbjct: 129 SENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHAC 188 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ 232 + + +GTP Y+APE+L D+W+ G+ Y++L PF + Y Q Sbjct: 189 ELREIMGTPEYLAPEILNYDPITT-ATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQ 247 Query: 233 RILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNT 292 ++V YS +S I + V +P R + +HSW + +L + T Sbjct: 248 --VNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEET 305 Query: 293 GSQFQEPEQPMQSLDTIMQIIS 314 S Q + ++S + S Sbjct: 306 SSSSQTQDHSVRSSEDKTSKSS 327 >3A8W-A nrPDB Length = 345 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 80/304 (26%), Positives = 140/304 (46%), Gaps = 23/304 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER-----GDKIDENVQREIINHRSLRH 75 +D ++ IG G++ L+R K T + A+K +++ + ID + + ++ H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V T + L ++EY +GG+L + + E+ ARF+ ++ ++Y H Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-LHSQPKSTVGTPAYIAPEVLLRQEY 194 I +RDLKL+N LLD +K+ D+G K + + GTP YIAPE+L ++Y Sbjct: 130 GIIYRDLKLDNVLLDSE--GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 187 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFE-----DPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 G D W+ GV ++ M+ G PF+ D + Q IL + IP +S Sbjct: 188 -GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS--LSV 244 Query: 250 ECCHLISRIFVADPATRI------SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPM 303 + ++ DP R+ +I+ H +F +N+ D+M + F+ Sbjct: 245 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF-RNVDWDMMEQKQVVPPFKPNISGE 303 Query: 304 QSLD 307 LD Sbjct: 304 FGLD 307 >4KS7-A nrPDB Length = 292 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 72/257 (28%), Positives = 128/257 (49%), Gaps = 9/257 (3%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ L R+K + VAVK ++ R + E + E++ R +H N+V + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY 89 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I + R +E++ + +L ++Y H+ + HRD+K + Sbjct: 90 LVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 148 Query: 146 NTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ + KS VGTP ++APEV+ R Y + D+WS Sbjct: 149 SILLTLD--GRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATE-VDIWSL 205 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + ++ S + + ++SP + R+ V DP Sbjct: 206 GIMVIEMVDGEPPYFSDSPVQAMKRLRD---SPPPKLKNSHKVSPVLRDFLERMLVRDPQ 262 Query: 265 TRISIPEIKTHSWFLKN 281 R + E+ H + L+ Sbjct: 263 ERATAQELLDHPFLLQT 279 >4BBM-A nrPDB Length = 331 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 127/316 (40%), Gaps = 32/316 (10%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KID 60 + V G ++ ++Y+ + +G G++G+ R+K T +VA+K D + Sbjct: 10 SGVDLGTENLYFQS-MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK 68 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 + REI + LRH N+V EV ++ E+ L + + Sbjct: 69 KIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQK 128 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVG 179 + Q+++G+ +CHS I HRD+K EN L+ S +K+CDFG++++ V Sbjct: 129 YLFQIINGIGFCHSHNIIHRDIKPENILVSQSGV--VKLCDFGFARTLAAPGEVYDDEVA 186 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI-------- 231 T Y APE+L+ GK DVW+ G + M +G F + + Sbjct: 187 TRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIP 246 Query: 232 --------------QRILSVKYSIP---DDIRISPECCHLISRIFVADPATRISIPEIKT 274 R+ +K P ++S L + DP R E+ Sbjct: 247 RHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLH 306 Query: 275 HSWFLKNLPADLMNES 290 H +F + A+ ++ Sbjct: 307 HDFFQMDGFAERFSQE 322 >4AF3-A nrPDB Length = 292 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 84/280 (30%), Positives = 134/280 (47%), Gaps = 15/280 (5%) Query: 7 TTGPLDMPIMHDS-DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---- 61 ++G D+ H + D ++ + +G G FG L R+K + +VA+K + + E Sbjct: 9 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH 68 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFF 121 ++REI L HPNI+R + +I+EYA GELY+ + + F E Sbjct: 69 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI 128 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 ++L + YCH ++ HRD+K EN L LKI DFG+S + K+ GT Sbjct: 129 MEELADALMYCHGKKVIHRDIKPEN--LLLGLKGELKIADFGWS-VHAPSLRRKTMCGTL 185 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 Y+ PE++ + ++ K D+W GV Y +LVG PFE YR RI+ V Sbjct: 186 DYLPPEMIEGRMHNEK-VDLWCIGVLCYELLVGNPPFESASHNETYR----RIVKVDLKF 240 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 P + LIS++ +P+ R+ + ++ H W N Sbjct: 241 P--ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 278 >4XBR-A nrPDB Length = 366 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 13/272 (4%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ + + + +LVAVK ++ R + E + E++ R +H N+V Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 160 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I R +E++ +L +S H+ + HRD+K + Sbjct: 161 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 219 Query: 146 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ ++ S + KS VGTP ++APE++ R Y G D+WS Sbjct: 220 SILLTHD--GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSL 276 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + + + + + + ++SP + R+ V DPA Sbjct: 277 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNL---PPRLKNLHKVSPSLKGFLDRLLVRDPA 333 Query: 265 TRISIPEIKTHSWFLKNLPA----DLMNESNT 292 R + E+ H + K P LM ++ T Sbjct: 334 QRATAAELLKHPFLAKAGPPASIVPLMRQNRT 365 >3HKO-A nrPDB Length = 345 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 129/317 (40%), Gaps = 54/317 (17%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD------KIDENVQREIIN 69 + +Y IG G++GV R+ + T+ + A+K + + K E ++ E+ Sbjct: 22 LELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRL 81 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI---------------------- 107 + L HPNI R EV ++ ++ME GG L +++ Sbjct: 82 MKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICP 141 Query: 108 ---CNAGRFS---------------EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL 149 CN + E +Q+ S + Y H+ ICHRD+K EN L Sbjct: 142 CPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLF 201 Query: 150 DGSPAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAYIAPEVLL-RQEYDGKIADVWS 203 + + +K+ DFG SK + + GTP ++APEVL E G D WS Sbjct: 202 STNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWS 261 Query: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 GV L+++L+GA PF + + + + L + P+ +SP L+S + + Sbjct: 262 AGVLLHLLLMGAVPFPGVNDADTISQVLNKKLC--FENPNYNVLSPLARDLLSNLLNRNV 319 Query: 264 ATRISIPEIKTHSWFLK 280 R H W + Sbjct: 320 DERFDAMRALQHPWISQ 336 >6QAU-A nrPDB Length = 280 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 87/282 (30%), Positives = 136/282 (48%), Gaps = 15/282 (5%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKL-TKELVAVKYIERGDKIDENVQ--R 65 G M ++ D + Y +G G F V R + T VA+K I + + + + Sbjct: 1 GGGSMEVVGDFE-YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK 59 Query: 66 EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 EI + L+H NIV +V P + ++MEY +GG+L + + G SED R F Q+ Sbjct: 60 EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQI 119 Query: 126 LSGVSYCHSMQICHRDLKLENTLL-------DGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 + + HS I HRDLK +N LL R+KI DFG+++ + Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC 179 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 G+P Y+APEV++ Q YD K AD+WS G +Y LVG PF+ P+D R ++ S+ Sbjct: 180 GSPMYMAPEVIMSQHYDAK-ADLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYEKNRSLM 237 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 SIP + SP +L+ + + R+ +H + + Sbjct: 238 PSIPRET--SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 277 >4C0T-A nrPDB Length = 974 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 140/308 (45%), Gaps = 28/308 (9%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP---- 76 + F K++G G++ L DK+T + AVK +++ I E + + + + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 77 -NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 ++ L +++YAS GEL I +E+ R F Q+L + Y H Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDN 386 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVGTPAYIA 185 + HRDLK EN LLD R++I DFG ++ + + KS VGT Y++ Sbjct: 387 GVIHRDLKPENILLDDKM--RIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE LL +Y GK DVW+ G +Y M+ G PF+ E ++K + + P I Sbjct: 445 PE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTII 503 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFL----KNLPADLMNESNTGSQFQEPEQ 301 R LI +I V P+ R +IPEI+ H +F K+ + +++ ++ + Sbjct: 504 R------DLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAK 557 Query: 302 PMQSLDTI 309 M + + Sbjct: 558 SMMKVPEL 565 >2F57-A nrPDB Length = 317 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 73/263 (27%), Positives = 128/263 (48%), Gaps = 9/263 (3%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLRHPNIVRFKEVI 85 IG G+ G+ + +K T + VAVK ++ R + E + E++ R H N+V Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 111 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLE 145 L L ++ME+ GG L + I R +E++ +L +SY H+ + HRD+K + Sbjct: 112 LVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 170 Query: 146 NTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 + LL R+K+ DFG+ ++ S + KS VGTP ++APEV+ R Y G D+WS Sbjct: 171 SILLTSD--GRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSL 227 Query: 205 GVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPA 264 G+ + M+ G P+ + + R+ S+ + D ++S + + V +P+ Sbjct: 228 GIMVIEMIDGEPPYFNEPPLQAMRRIRD---SLPPRVKDLHKVSSVLRGFLDLMLVREPS 284 Query: 265 TRISIPEIKTHSWFLKNLPADLM 287 R + E+ H + P + Sbjct: 285 QRATAQELLGHPFLKLAGPPSCI 307 >4WNO-A nrPDB Length = 287 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 79/270 (29%), Positives = 126/270 (46%), Gaps = 16/270 (5%) Query: 21 RYDFVKD--IGSGNFGVARLMRDKLTKE-LVAVKYIERGDKIDENVQ--REIINHRSLRH 75 +++F + IG G F V R + + VAVK I + + +EI + L+H Sbjct: 17 KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 NIV + + ++MEY +GG+L + + SED R F QQ+ + HS Sbjct: 77 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSK 136 Query: 136 QICHRDLKLENTLLD-------GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 I HRDLK +N LL + R+KI DFG+++ + + G+P Y+APEV Sbjct: 137 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEV 196 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 ++ Q YDGK AD+WS G +Y L G PF+ P+D R ++ ++ +IP + Sbjct: 197 IMSQHYDGK-ADLWSIGTIVYQCLTGKAPFQ-ASSPQDLRLFYEKNKTLVPTIPRETSAP 254 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWF 278 + + R+ E H + Sbjct: 255 LRQLL--LALLQRNHKDRMDFDEFFHHPFL 282 >5LOH-A nrPDB Length = 341 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 135/302 (44%), Gaps = 23/302 (7%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQRE 66 + +P + + VK I G FG L + +L AVK +++ D I++N VQ E Sbjct: 27 IAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAE 84 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLL 126 + P IV + + ++ ++MEY GG++ + G F E+ A + ++ Sbjct: 85 RDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVA 144 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-------SSVLHSQPKSTVG 179 + Y H I HRDLK +N L+ +K+ DFG SK + + ++ G Sbjct: 145 LALDYLHRHGIIHRDLKPDNMLISNE--GHIKLTDFGLSKVTLNRDINMMDILTTRTFCG 202 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 TP Y+APE+LL + + G D W+ GV L+ L G PF D ++ Q IL Sbjct: 203 TPDYLAPELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFND----ETPQQVFQNILKRDI 257 Query: 240 SIPD-DIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 P+ + ++S + + D R + E+K H F +L ++ T + Sbjct: 258 PWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQ--TMPFIPQ 315 Query: 299 PE 300 P+ Sbjct: 316 PD 317 >1V0B-A nrPDB Length = 288 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 127/290 (43%), Gaps = 32/290 (11%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHP 76 ++Y ++ IG G +GV ++ E A+K I + + I REI + L+H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSM 135 NIV+ +VI T L ++ E+ +L + + G A+ F QLL+G++YCH Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLD-QDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQEY 194 ++ HRDLK +N L++ LKI DFG +++ + + V T Y AP+VL+ + Sbjct: 120 RVLHRDLKPQNLLINRE--GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR-------- 246 D+WS G M+ GA F E + + + + ++ Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 247 ---------------ISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 + L+S++ DP RI+ + H++F +N Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >2I0E-A nrPDB Length = 353 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 90/293 (30%), Positives = 141/293 (48%), Gaps = 25/293 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-DENVQREIINHRSL----RH 75 ++F+ +G G+FG L K T EL AVK +++ I D++V+ ++ R L + Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 80 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P + + T L +MEY +GG+L I GRF E A F+ ++ G+ + S Sbjct: 81 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK 140 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEY 194 I +RDLKL+N +LD +KI DFG K ++ K+ GTP YIAPE++ Q Y Sbjct: 141 GIIYRDLKLDNVMLDSE--GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 198 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 GK D W+ GV LY ML G PFE +E ++ ++ ++ S+ S E + Sbjct: 199 -GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM------SKEAVAI 251 Query: 255 ISRIFVADPATRISI-----PEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 + P R+ +IK H++F + E + Q P +P Sbjct: 252 CKGLMTKHPGKRLGCGPEGERDIKEHAFFR-----YIDWEKLERKEIQPPYKP 299 >6BDL-A nrPDB Length = 347 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 137/287 (47%), Gaps = 17/287 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTK-ELVAVKYIERGDKIDENVQREIINHRSL----RH 75 ++ + +G G FG L++ K + + A+K +++ +D Q I + + + Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 IVR +L ++ME GGEL+ + + G F + RF+ ++ +Y HS Sbjct: 95 DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSK 154 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 I +RDLK EN +LD K+ DFG++K + + GTP Y+APE++L + +D Sbjct: 155 GIIYRDLKPENLILDH--RGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 212 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 AD WS G+ +Y +L G+ PF P+ + Y ++ I +++ +I+ +LI Sbjct: 213 I-SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP----KKIAKNAANLI 267 Query: 256 SRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQ 297 ++ +P+ R+ + +I+ H WF L + T Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIP 314 >5Z33-A nrPDB Length = 425 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 79/339 (23%), Positives = 135/339 (39%), Gaps = 45/339 (13%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLR 74 +RY K++G G +G+ + T E VA+K + + + REI + R Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 75 -HPNIVRFKEVILTPTHL----AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 H NI ++ + + E +L I + ++ + F Q+L G+ Sbjct: 89 GHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCGL 147 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTPAYI 184 Y HS + HRDLK N L++ LKICDFG ++ + + V T Y Sbjct: 148 KYIHSANVLHRDLKPGNLLVNAD--CELKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV------- 237 APE++L + K DVWS G L +L G PF + D I IL Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETLS 264 Query: 238 ------------------KYSIPD-DIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 K P +P+ L+ R+ DP++RIS+ + H + Sbjct: 265 RIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 Query: 279 LKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEAT 317 ++ D +E + + F + ++ + + ++I + Sbjct: 325 --HIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEV 361 >4XEY-B nrPDB Length = 408 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 116/299 (38%), Gaps = 22/299 (7%) Query: 4 APVTTGPLDMPIMHDSDRYDFVK-------DIGSGNFGVARLMRDKLTKELVAVKYIERG 56 AP P + + D+++ + +G G +G K VAVK ++ Sbjct: 102 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED 161 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFS 114 E +E + ++HPN+V+ V II E+ + G L + + CN + Sbjct: 162 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 221 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHS 172 + Q+ S + Y HRDL N L+ + +K+ DFG S+ + ++ Sbjct: 222 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYT 279 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTI 231 + APE L ++ K +DVW+ GV L+ + G P+ + + Y Sbjct: 280 AHAGAKFPIKWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGIDLSQVYE--- 335 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 +L Y + + L+ + +P+ R S EI H F +++ Sbjct: 336 --LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 390 >4FZF-B nrPDB Length = 283 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 73/269 (27%), Positives = 124/269 (46%), Gaps = 16/269 (5%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRH 75 + + ++ IG G+FG D T+++VA+K I+ + E++Q+EI Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 65 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 + ++ L + L IIMEY GG + + AG F E + +++L G+ Y HS Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEILKGLDYLHSE 124 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEY 194 + HRD+K N LL S +K+ FG + + + VGTP ++APEV+ + Y Sbjct: 125 KKIHRDIKAANVLL--SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 182 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECC 252 D K AD+WS G+T + G P D ++ + + + P + + Sbjct: 183 DSK-ADIWSLGITAIELAKGEPPNSDMHP-------MRVLFLIPKNNPPTLVGDFTKSFK 234 Query: 253 HLISRIFVADPATRISIPEIKTHSWFLKN 281 I DP+ R + E+ H + +KN Sbjct: 235 EFIDACLNKDPSFRPTAKELLKHKFIVKN 263 >3Q53-A nrPDB Length = 306 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 129/294 (43%), Gaps = 9/294 (3%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHR 71 + + +Y + IG G G D T + VA++ + + + + EI+ R Sbjct: 14 VSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMR 73 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 ++PNIV + + L L ++MEY +GG L + + E + ++ L + + Sbjct: 74 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEF 132 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLL 190 HS Q+ HRD+K +N LL + +K+ DFG+ +ST VGTP ++APEV+ Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGS--VKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 R+ Y G D+WS G+ M+ G P+ + E P I + + P+ ++S Sbjct: 191 RKAY-GPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIATNGTPELQNPE--KLSAI 246 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQ 304 ++R D R S E+ H + P + ++ ++ Sbjct: 247 FRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSSLTPLIAAAKEATKNNHLE 300 >3ZDU-A nrPDB Length = 325 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 124/318 (38%), Gaps = 39/318 (12%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 + Y+ + +G G++G + K T ++VA+K +++ REI + H N Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 62 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V EV + ++ E+ L E R + Q+L + Y HS I Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 HRD+K EN L+ S K+CDFG++++ V T Y APE++L+ G Sbjct: 123 IHRDIKPENILVSQSGIT--KLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC----- 251 K D+W+ G + M G + K + ++ ++ + + SP Sbjct: 181 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 240 Query: 252 --------------------CHLISRIFVADPATRISIPEIKTHSWFLKN---------L 282 ++ DPA RIS ++ H +F ++ L Sbjct: 241 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 300 Query: 283 PADLMNESNTGSQFQEPE 300 A L+ E+ S + E Sbjct: 301 KAKLLQEAKVNSLIKPKE 318 >3NYO-A nrPDB Length = 576 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 86/376 (22%), Positives = 149/376 (39%), Gaps = 41/376 (10%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI- 59 ++R PVT + + + +G G FG + + T ++ A K +E+ Sbjct: 176 LERQPVTK-----------NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK 224 Query: 60 ---DENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FS 114 + E + +V T L +++ +GG+L I + G+ F Sbjct: 225 RKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP 284 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 E A F+ ++ G+ H +I +RDLK EN LLD ++I D G + Sbjct: 285 EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTI 342 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 K VGT Y+APEV+ + Y D W+ G LY M+ G PF+ + + R+ ++R+ Sbjct: 343 KGRVGTVGYMAPEVVKNERYTFSP-DWWALGCLLYEMIAGQSPFQ-QRKKKIKREEVERL 400 Query: 235 LSVKYSIPDDI--RISPECCHLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLM 287 + +P++ R SP+ L S++ DPA R+ S E+K H F K L + Sbjct: 401 VK---EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK-LNFKRL 456 Query: 288 NESNTGSQFQEPEQPMQSLD----TIMQIISEATIPAVRNRCLDDFMTDN-----LDLDD 338 F+ Q + D + + F T + + Sbjct: 457 GAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMV 516 Query: 339 DMDDFDSESEIDIDSS 354 + + F + +D S Sbjct: 517 ETECFQELNVFGLDGS 532 >2FO0-A nrPDB Length = 495 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 116/299 (38%), Gaps = 22/299 (7%) Query: 4 APVTTGPLDMPIMHDSDRYDFVK-------DIGSGNFGVARLMRDKLTKELVAVKYIERG 56 AP P + + D+++ + +G G +G K VAVK ++ Sbjct: 194 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED 253 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFS 114 E +E + ++HPN+V+ V II E+ + G L + + CN + Sbjct: 254 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 313 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHS 172 + Q+ S + Y HR+L N L+ + +K+ DFG S+ + ++ Sbjct: 314 AVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHL--VKVADFGLSRLMTGDTYT 371 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTI 231 + APE L ++ K +DVW+ GV L+ + G P+ + + Y Sbjct: 372 AHAGAKFPIKWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGIDLSQVYE--- 427 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 +L Y + + L+ + +P+ R S EI H F +++ Sbjct: 428 --LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 482 >3TKU-A nrPDB Length = 433 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 122/284 (42%), Gaps = 20/284 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRH 75 + ++ +K IG G FG +++ K T+ + A+K + + + + + E + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCHS 134 I HL ++M+Y GG+L + + ED ARF+ +++ + H Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 209 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLL-- 190 + HRD+K +N LLD + +++ DFG Q VGTP YI+PE+L Sbjct: 210 LHYVHRDIKPDNVLLDVN--GHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 191 --RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-RI 247 G D WS GV +Y ML G PF Y K + ++ P + + Sbjct: 268 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--EERFQFPSHVTDV 325 Query: 248 SPECCHLISRIFVADPATRI---SIPEIKTHSWFLKNLPADLMN 288 S E LI R+ + R+ I + K H++F ++ N Sbjct: 326 SEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLNWENIRN 368 >4MYG-A nrPDB Length = 372 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 129/310 (41%), Gaps = 41/310 (13%) Query: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKI 59 + ++ Y +GSG +G DK + E VA+K + R + Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRF 113 + RE++ + ++H N++ +V + L ++M + +L + + F Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIM--GMEF 142 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 SE++ ++ Q+L G+ Y HS + HRDLK N ++ LKI DFG ++ + ++ Sbjct: 143 SEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNED--CELKILDFGLARHA--DAE 198 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ- 232 V T Y APEV+L + + D+WS G + ML G F+ + + ++ Sbjct: 199 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 258 Query: 233 -RILSVKY--------------SIPD---------DIRISPECCHLISRIFVADPATRIS 268 + ++ S+P R SP+ L+ ++ D R++ Sbjct: 259 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT 318 Query: 269 IPEIKTHSWF 278 + TH +F Sbjct: 319 AAQALTHPFF 328 >2XIK-A nrPDB Length = 294 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 80/267 (29%), Positives = 119/267 (44%), Gaps = 14/267 (5%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRH 75 + + + IG G+FG D TKE+VA+K I+ + E++Q+EI Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 76 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P I R+ L T L IIMEY GG + + G E +++L G+ Y HS Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHSE 135 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS-QPKSTVGTPAYIAPEVLLRQEY 194 + HRD+K N LL S +K+ DFG + + + VGTP ++APEV+ + Y Sbjct: 136 RKIHRDIKAANVLL--SEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD-DIRISPECCH 253 D K AD+WS G+T + G P D R L K S P + + S Sbjct: 194 DFK-ADIWSLGITAIELAKGEPPNSDLHPMRVL------FLIPKNSPPTLEGQHSKPFKE 246 Query: 254 LISRIFVADPATRISIPEIKTHSWFLK 280 + DP R + E+ H + + Sbjct: 247 FVEACLNKDPRFRPTAKELLKHKFITR 273 >6CCF-A nrPDB Length = 290 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 89/297 (29%), Positives = 135/297 (45%), Gaps = 47/297 (15%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAV----------------------------- 50 ++Y +IG G +GV RL ++ A+ Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 51 --KYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTP--THLAIIMEYASGGELYER 106 K + E V +EI + L H N+V+ EV+ P +L ++ + G + E Sbjct: 65 PAKQL----LPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV 120 Query: 107 ICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 C+ FSE++AR + + ++ G+ Y H +I HRD+K N LL +KI DFG S Sbjct: 121 PCD-KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDD--GHVKIADFGVSN 177 Query: 167 SSV-LHSQPKSTVGTPAYIAPEVL--LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 +Q ST GTPA++APE + Q + GK DVW+ GVTLY + G PF D Sbjct: 178 QFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDD-- 235 Query: 224 PRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 ++I + P++ IS E LI ++ +P TRI +P+IK H W K Sbjct: 236 --FILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >4IC8-A nrPDB Length = 442 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 125/307 (40%), Gaps = 42/307 (13%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQREIINHRSLR 74 D Y+ ++ IG+G +GV R +LT + VA+K I + + RE+ + + Sbjct: 53 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK 112 Query: 75 HPNIVRFKEVIL------TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 H NI+ K+++ + ++++ +L++ I ++ + + R+F QLL G Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRG 171 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAY 183 + Y HS Q+ HRDLK N L++ + LKI DFG ++ V T Y Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI------------ 231 APE++L + D+WS G ML F + + Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 232 ----QRILSVKYSIPDDIRISPE---------CCHLISRIFVADPATRISIPEIKTHSWF 278 +R+ + S+P + E L+ R+ +P+ RIS H + Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 349 Query: 279 LKNLPAD 285 K D Sbjct: 350 AKYHDPD 356 >4AW2-A nrPDB Length = 437 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 121/284 (42%), Gaps = 20/284 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRH 75 + ++ +K IG G FG +++ K ++ A+K + + + + + E + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCHS 134 I +L ++M+Y GG+L + R E+ ARF+ +++ + H Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQ 193 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLL-- 190 + HRD+K +N L+D + +++ DFG + Q VGTP YI+PE+L Sbjct: 194 LHYVHRDIKPDNILMDMN--GHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 191 --RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-RI 247 + G D WS GV +Y ML G PF Y K + ++ P + + Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--KERFQFPTQVTDV 309 Query: 248 SPECCHLISRIFVADPATRI---SIPEIKTHSWFLKNLPADLMN 288 S LI R+ + R+ I + K H +F ++ N Sbjct: 310 SENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFSGIDWDNIRN 352 >4QNY-A nrPDB Length = 354 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 129/334 (38%), Gaps = 39/334 (11%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYIERG----DK 58 A + L + DRY + IG+G++GV RD K LVA+K + + Sbjct: 4 ATKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVI 63 Query: 59 IDENVQREIINHRSLRHPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRF 113 + + + REI NI+ + ++ H I+M+ +L + + + Sbjct: 64 LAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQEL 122 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 +E +FF Q L + HS + HRD+ N L++ + LKICDFG +K + Sbjct: 123 TEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTN--CDLKICDFGLAKEENDQGE 180 Query: 174 PKSTVGT-PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI- 231 + T Y APE+++ + DVW G L +L F+ + K + Sbjct: 181 YMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVD 240 Query: 232 ------------------QRILSVKYSIPD------DIRISPECCHLISRIFVADPATRI 267 Q+ L K P SPE L+ + V +P RI Sbjct: 241 VIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRI 300 Query: 268 SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 ++ + H + + N S +F E EQ Sbjct: 301 TVLQAMRHPFLEQLHDDADDNLSYALFRFDENEQ 334 >4APC-A nrPDB Length = 350 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 141/292 (48%), Gaps = 15/292 (5%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKID 60 + V G ++ ++Y ++ IG G+FG A L++ +K I K Sbjct: 9 SGVDLGTENLYFQS-MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER 67 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEA 118 E +RE+ +++HPNIV+++E L I+M+Y GG+L++RI F ED+ Sbjct: 68 EESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQI 127 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKST 177 +F Q+ + + H +I HRD+K +N L +++ DFG ++ + ++ Sbjct: 128 LDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGT--VQLGDFGIARVLNSTVELARAC 185 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 +GTP Y++PE+ + Y+ K +D+W+ G LY + + FE + + +I+S Sbjct: 186 IGTPYYLSPEICENKPYNNK-SDIWALGCVLYELCTLKHAFEAGS----MKNLVLKIISG 240 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 + P + S + L+S++F +P R S+ I + K + L + Sbjct: 241 SFP-PVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQ 291 >5Y86-A nrPDB Length = 588 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 80/362 (22%), Positives = 130/362 (35%), Gaps = 66/362 (18%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH 70 + +P H + RY+ +K IG G+FG + D ++ VA+K + + EI Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 Query: 71 RSLR------HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFF 122 L+ N++ E H+ + E S +LYE I FS R F Sbjct: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFA 316 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 182 Q +L + H +I H DLK EN LL K+ DFG S + + + + + Sbjct: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRF 374 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYR-----------KTI 231 Y APE++L Y D+WS G L +L G F +E K + Sbjct: 375 YRAPEIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Query: 232 QRILSVKY-----SIPDDIRISPEC----------------------------------- 251 ++ KY IP ++ + Sbjct: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 Query: 252 --CHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN-ESNTGSQFQEPEQPMQSLDT 308 + R DP+ R++ + H W K++P L + +G + P Q L + Sbjct: 494 LFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGS 553 Query: 309 IM 310 + Sbjct: 554 KL 555 >3QA8-A nrPDB Length = 676 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 141/330 (42%), Gaps = 22/330 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKIDENVQREIINHRSLRHPNIV 79 ++ + +G+G FG + T E VA+K + K E EI + L HPN+V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 80 RFKEV-----ILTPTHLAII-MEYASGGELYERIC---NAGRFSEDEARFFFQQLLSGVS 130 +EV L P L ++ MEY GG+L + + N E R + S + Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H +I HRDLK EN +L P + KI D GY+K VGT Y+APE+L Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++Y D WS G + + G PF +P + ++ + + DD+ + Sbjct: 196 EQKKYTV-TVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTGAV 254 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP-MQSLDT 308 + ++ P I K W L + ++ G+ Q P Q+LD+ Sbjct: 255 KFSSVL-----PTPNHLSGILAGKLERWLQCML---MWHQRQRGTDPQNPNVGCFQALDS 306 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNLDLDD 338 I+ + + + V R +T+N +L + Sbjct: 307 ILSLKLLSVMNMVSGRVHTYPVTENENLQN 336 >5AIR-A nrPDB Length = 430 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 93/365 (25%), Positives = 141/365 (38%), Gaps = 46/365 (12%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ 64 V P P Y K IG+G+FGV + + ELVA+K + + + Sbjct: 49 TVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---N 105 Query: 65 REIINHRSLRHPNIVRFKEVIL------TPTHLAIIMEYASGGELY---ERICNAGRFSE 115 RE+ R L H NIVR + +L ++++Y Sbjct: 106 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV 165 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 175 + + QL ++Y HS ICHRD+K +N LLD LK+CDFG +K V Sbjct: 166 IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD-TAVLKLCDFGSAKQLVRGEPNV 224 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 S + + Y APE++ DVWS G L +L+G F + I+ + Sbjct: 225 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 284 Query: 236 S-------------VKYSIPD----------DIRISPECCHLISRIFVADPATRISIPEI 272 + ++ P R PE L SR+ P R++ E Sbjct: 285 TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 344 Query: 273 KTHSWF--LKNLPADLMNESNTGSQFQEPEQPMQS---LDTIM-----QIISEATIPAVR 322 HS+F L++ L N +T + F Q + S L TI+ +I + A+ PA Sbjct: 345 CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANA 404 Query: 323 NRCLD 327 D Sbjct: 405 TAASD 409 >4QTB-A nrPDB Length = 380 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 135/348 (38%), Gaps = 45/348 (12%) Query: 5 PVTTGPLDMPIMHDSD---RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKI 59 P G ++M D RY ++ IG G +G+ D + K VA+K I Sbjct: 23 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY 82 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFS 114 + REI RH N++ ++++ T + I+ + +LY+ + + S Sbjct: 83 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LS 140 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVL 170 D +F Q+L G+ Y HS + HRDLK N L++ + LKICDFG ++ Sbjct: 141 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDH 198 Query: 171 HSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT 230 V T Y APE++L + K D+WS G L ML F Sbjct: 199 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 258 Query: 231 --------------IQRILSVKY--SIPDDIRI---------SPECCHLISRIFVADPAT 265 I + + Y S+P ++ + L+ R+ +P Sbjct: 259 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 318 Query: 266 RISIPEIKTHSWFLK--NLPADLMNESNTGSQFQEPEQPMQSLDTIMQ 311 RI++ E H + + + + + E + + P + L ++ Sbjct: 319 RITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIF 366 >2F9G-A nrPDB Length = 353 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 84/336 (25%), Positives = 126/336 (37%), Gaps = 49/336 (14%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK--IDENVQREIINHRSLRHP 76 S + +G G +GV K T E+VA+K IE DK REI + +H Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 Query: 77 NIVRFK-----EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 NI+ + + II E +L+ R+ + S+D ++F Q L V Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQ-TDLH-RVISTQMLSDDHIQYFIYQTLRAVKV 127 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-----------HSQPKSTVGT 180 H + HRDLK N L++ + LK+CDFG ++ S V T Sbjct: 128 LHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK-- 238 Y APEV+L + DVWSCG L + + F + I + Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 239 ---------------YSIPDD---------IRISPECCHLISRIFVADPATRISIPEIKT 274 S+P R++P+ L+ R+ V DPA RI+ E Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 Query: 275 HSWFLK-NLPADLMNESNTGSQFQEPEQPMQSLDTI 309 H + + P D F E + ++L T Sbjct: 306 HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTK 341 >3GC0-A nrPDB Length = 329 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 86/315 (27%), Positives = 126/315 (40%), Gaps = 37/315 (11%) Query: 7 TTGPLDM-----PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDK 58 T GP M P DRY + +G G +G D +T E VA+K I + Sbjct: 16 TQGPGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEG 75 Query: 59 IDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEA 118 + RE+ + L+H NI+ K VI L +I EYA +L + + S Sbjct: 76 VPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVI 134 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLL---DGSPAPRLKICDFGYSKSS-VLHSQP 174 + F QL++GV++CHS + HRDLK +N LL D S P LKI DFG +++ + Q Sbjct: 135 KSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQF 194 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 + T Y PE+LL + D+WS ML+ F E K + + Sbjct: 195 THEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVL 254 Query: 235 L-------SVKYSIPDDIRISPECC-HLISR----------------IFVADPATRISIP 270 ++PD + P+ + R + DP RIS Sbjct: 255 GLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAK 314 Query: 271 EIKTHSWFLKNLPAD 285 H +F N Sbjct: 315 NALEHPYFSHNDFDP 329 >4ZSG-A nrPDB Length = 347 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 125/307 (40%), Gaps = 42/307 (13%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQREIINHRSLR 74 D Y+ ++ IG+G +GV R +LT + VA+K I + + RE+ + + Sbjct: 5 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK 64 Query: 75 HPNIVRFKEVIL------TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 H NI+ K+++ + ++++ +L++ I ++ + + R+F QLL G Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRG 123 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-----VLHSQPKSTVGTPAY 183 + Y HS Q+ HRDLK N L++ + LKI DFG ++ V T Y Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNEN--CELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI------------ 231 APE++L + D+WS G ML F + + Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 232 ----QRILSVKYSIPDDIRISPE---------CCHLISRIFVADPATRISIPEIKTHSWF 278 +R+ + S+P + E L+ R+ +P+ RIS H + Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 Query: 279 LKNLPAD 285 K D Sbjct: 302 AKYHDPD 308 >3E7O-A nrPDB Length = 360 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 78/339 (23%), Positives = 132/339 (38%), Gaps = 54/339 (15%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRHP 76 RY +K IGSG G+ D + VAVK + R + + RE++ + + H Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK 81 Query: 77 NIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 NI+ V L ++ME L + I + + Q+L G+ Sbjct: 82 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--MELDHERMSYLLYQMLCGIK 138 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 + HS I HRDLK N ++ LKI DFG ++++ + V T Y APEV+L Sbjct: 139 HLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTASTNFMMTPYVVTRYYRAPEVIL 196 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI---------------- 234 Y + D+WS G + ++ G+ F+ + + K I+++ Sbjct: 197 GMGYK-ENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 235 -----------LSVKYSIPDDIRISPE---------CCHLISRIFVADPATRISIPEIKT 274 ++ + PD I S L+S++ V DP RIS+ E Sbjct: 256 NYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALR 315 Query: 275 HSWFLKNL---PADLMNESNTGSQFQEPEQPMQSLDTIM 310 H + A+ +Q +E E ++ ++ Sbjct: 316 HPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELI 354 >5AWM-A nrPDB Length = 394 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 118/304 (38%), Gaps = 52/304 (17%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDK---IDENVQREIINHRSLRHPN 77 RY ++ IGSG G+ D +T++ VA+K + R + + RE + + H N Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 78 IVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 I+ +L ++ME L + I D + Q+L G+ + Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ--MDLDHDRMSYLLYQMLCGIKH 161 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Sbjct: 162 LHSAGIIHRDLKPSNIVVKADCT--LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILG 219 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI---------- 241 Y + D+WS G + M+ G F + + K I+++ + S Sbjct: 220 MGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 242 -----PDDIRIS----------------------PECCHLISRIFVADPATRISIPEIKT 274 P S + +L+S++ V DP RIS+ E Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 275 HSWF 278 H + Sbjct: 339 HEYI 342 >5D7A-A nrPDB Length = 308 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 120/272 (44%), Gaps = 22/272 (8%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPNIVR 80 ++ V+ +G+G +G R T +L A+K ++ +E +++EI + H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 81 FKEVILTPTH------LAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYC 132 + + L ++ME+ G + + I N E+ + +++L G+S+ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLR 191 H ++ HRD+K +N LL + +K+ DFG S + + +GTP ++APEV+ Sbjct: 139 HQHKVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 196 Query: 192 QE-----YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 E YD K +D+WS G+T M GA P D R + I + Sbjct: 197 DENPDATYDFK-SDLWSLGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPAPRLKSKK 251 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S + I V + + R + ++ H + Sbjct: 252 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 283 >5NGU-A nrPDB Length = 381 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 127/329 (38%), Gaps = 42/329 (12%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNI 78 RY + IG G +G+ D L K VA+K I + REI RH NI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 79 VRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 + ++I PT + I+ + +LY+ + S D +F Q+L G+ Y H Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIH 160 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP----KSTVGTPAYIAPEVL 189 S + HRDLK N LL+ + LKICDFG ++ + V T Y APE++ Sbjct: 161 SANVLHRDLKPSNLLLNTT--CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI----------------QR 233 L + K D+WS G L ML F + + Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 234 ILSVKYSIPDDIRIS---------PECCHLISRIFVADPATRISIPEIKTHSWFLK--NL 282 + S+P ++ + L+ ++ +P RI + + H + + + Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 283 PADLMNESNTGSQFQEPEQPMQSLDTIMQ 311 + + E+ + + P + L ++ Sbjct: 339 SDEPIAEAPFKFDMELDDLPKEKLKELIF 367 >1G3N-A nrPDB Length = 326 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 123/315 (39%), Gaps = 41/315 (13%) Query: 21 RYDFVKDIGSGNFGVARLMRD-KLTKELVAVKYIERG---DKIDENVQREIINHRSLR-- 74 +Y+ V +IG G +G RD K VA+K + + + + RE+ R L Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 75 -HPNIVRFKEVIL-----TPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLL 126 HPN+VR +V T L ++ E+ +L + + + QLL Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 G+ + HS ++ HRDLK +N L+ S ++K+ DFG ++ S V T Y AP Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSS--GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYSIPDDI 245 EVLL+ Y D+WS G M F + K + I L + P D+ Sbjct: 189 EVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 246 RISPEC--------------------CHLISRIFVADPATRISIPEIKTHSWF--LKNLP 283 + + L+ + +PA RIS +H +F L+ Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 Query: 284 ADLMNESNTGSQFQE 298 +L + E Sbjct: 308 ENLDSHLPPSQNTSE 322 >5DBX-A nrPDB Length = 328 Score = 240 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 119/287 (41%), Gaps = 24/287 (8%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHR 71 PI D+ Y+ + IGSG V + K +E VA+K I E+ + + +EI Sbjct: 7 PICRDA--YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMS 64 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--------CNAGRFSEDEARFFFQ 123 HPN+V + + L ++M+ SGG + + I G E + Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ------PKST 177 ++L G+ Y H HRDLK N LL + ++I DFG S K Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGS--VQIADFGVSAFLATGGDVTRNKVRKDF 182 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 VGTP ++APEV+ + AD+WS G+T + GA P+ + T+Q Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 242 Query: 238 KYSIPDD----IRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 + +D + L+S DP+ R + E+ +F K Sbjct: 243 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >4TNB-A nrPDB Length = 590 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 80/341 (23%), Positives = 132/341 (38%), Gaps = 29/341 (8%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID 60 ++R PVT + + + +G G FG + + T ++ A K +E+ Sbjct: 176 LERQPVTK-----------NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK 224 Query: 61 EN----VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FS 114 E + +V T L +++ +GG+L I N G F Sbjct: 225 RKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 E+ A F+ ++L G+ H +RDLK EN LLD ++I D G + Sbjct: 285 EERALFYAAEILCGLEDLHHENTVYRDLKPENILLD--DYGHIRISDLGLAVKIPEGDLI 342 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 + VGT Y+APEVL Q Y G D W G +Y M+ G PF +E + +R+ Sbjct: 343 RGRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNE 289 L + + S E + + D R+ E+K H +F +N+ + Sbjct: 402 LETEEVY--SHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFF-RNMNFKRLEA 458 Query: 290 SNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFM 330 F + + D ++ I +T+ V DD Sbjct: 459 GMLDPPFVPDPRAVYCKD-VLDIEQFSTVKGVNLDHTDDDF 498 >2XYN-A nrPDB Length = 292 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 112/294 (38%), Gaps = 23/294 (7%) Query: 4 APVTTGPLDMPIMHDSDRYDFVK-------DIGSGNFGVARLMRDKLTKELVAVKYIERG 56 + V G ++ D+++ + +G G +G + K VAVK ++ Sbjct: 10 SGVDLGTENLYFQS-MDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 68 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFS 114 E +E + ++HPN+V+ V I+ EY G L + + CN + Sbjct: 69 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 128 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHS 172 + Q+ S + Y HRDL N L+ + +K+ DFG S+ + ++ Sbjct: 129 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV--VKVADFGLSRLMTGDTYT 186 Query: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTI 231 + APE L + K +DVW+ GV L+ + G P+ + + Y Sbjct: 187 AHAGAKFPIKWTAPESLAYNTFSIK-SDVWAFGVLLWEIATYGMSPYPGIDLSQVYD--- 242 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPAD 285 +L Y + P+ L+ + PA R S E TH F Sbjct: 243 --LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE--THQAFETMFHDS 292 >6E2O-A nrPDB Length = 295 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 81/284 (28%), Positives = 131/284 (46%), Gaps = 15/284 (5%) Query: 7 TTGPLDMPIMHDSDRYDFVK-----DIGSGNFGVARLMRDKLTKELVAVKYI-ERGDKID 60 +T D Y++ + +G G +G+ RD + +A+K I ER + Sbjct: 4 STEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS 63 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRF--SEDE 117 + + EI H+ L+H NIV++ + I ME GG L + + G +E Sbjct: 64 QPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQT 123 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS-VLHSQPKS 176 F+ +Q+L G+ Y H QI HRD+K +N L++ + + LKI DFG SK ++ ++ Sbjct: 124 IGFYTKQILEGLKYLHDNQIVHRDIKGDNVLIN-TYSGVLKISDFGTSKRLAGINPCTET 182 Query: 177 TVGTPAYIAPEVL-LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 GT Y+APE++ GK AD+WS G T+ M G PF + EP+ + + Sbjct: 183 FTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKV-GMF 241 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 V IP+ +S E I + F DP R ++ + Sbjct: 242 KVHPEIPES--MSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >2XS0-A nrPDB Length = 386 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 78/341 (22%), Positives = 128/341 (37%), Gaps = 58/341 (17%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRHP 76 RY +K IGSG G+ D + + VA+K + R + + RE++ + + H Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 85 Query: 77 NIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 NI+ V L I+ME L + I + + Q+L G+ Sbjct: 86 NIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIK 142 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Sbjct: 143 HLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMVPFVVTRYYRAPEVIL 200 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI--------- 241 Y + D+WS G + M+ G F + + K I+++ + Sbjct: 201 GMGYK-ENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVR 259 Query: 242 ------PDDIRIS---------------------PECCHLISRIFVADPATRISIPEIKT 274 P S + L+S++ V D + RIS+ E Sbjct: 260 TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ 319 Query: 275 HSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 H + + + ++ P+ P + LD I E Sbjct: 320 HPYI-------NVWYDPSEAEAPPPKIPDKQLDEREHTIEE 353 >6NPU-A nrPDB Length = 298 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 108/290 (37%), Gaps = 15/290 (5%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR 65 P + +G G +G K VAVK ++ E + Sbjct: 12 FQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 71 Query: 66 EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQ 123 E + ++HPN+V+ V II E+ + G L + + CN + + Sbjct: 72 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 131 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTP 181 Q+ S + Y HRDL N L+ + +K+ DFG S+ + ++ Sbjct: 132 QISSAMEYLEKKNFIHRDLAARNCLVGENHL--VKVADFGLSRLMTGDTYTAHAGAKFPI 189 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYS 240 + APE L ++ K +DVW+ GV L+ + G P+ + + Y +L Y Sbjct: 190 KWTAPESLAYNKFSIK-SDVWAFGVLLWEIATYGMSPYPGIDLSQVYE-----LLEKDYR 243 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 + + L+ + +P+ R S EI H F +++ Sbjct: 244 MERPEGCPEKVYELMRACWQWNPSDRPSFAEI--HQAFETMFQESSISDE 291 >2UV2-A nrPDB Length = 325 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 72/272 (26%), Positives = 124/272 (45%), Gaps = 14/272 (5%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLR 74 ++ D ++ + ++G G FG ++K T L A K I+ + ++ E+ EI S Sbjct: 33 LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCD 92 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCH 133 HPNIV+ + +L I++E+ +GG + + +E + + +Q L ++Y H Sbjct: 93 HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEVLL-- 190 +I HRDLK N L +K+ DFG S + Q + S +GTP ++APEV++ Sbjct: 153 DNKIIHRDLKAGNILFTLD--GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 210 Query: 191 ---RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 + YD K ADVWS G+TL M P E R ++ S ++ R Sbjct: 211 TSKDRPYDYK-ADVWSLGITLIEMAEIEPP---HHELNPMRVLLKIAKSEPPTLAQPSRW 266 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFL 279 S + + + R + ++ H + Sbjct: 267 SSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >6BXI-A nrPDB Length = 333 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 134/302 (44%), Gaps = 49/302 (16%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRH 75 + ++ +K IG G FG RL++ K T + A+K + + D +++ ++ E Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 +V+ +L +IME+ GG++ + +E+E +F+ + + + H + Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 125 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV-----------------------LHS 172 HRD+K +N LLD +K+ DFG ++S Sbjct: 126 GFIHRDIKPDNLLLDSK--GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 173 QPK-------------STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 + K STVGTP YIAPEV ++ Y+ K+ D WS GV +Y ML+G PF Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFC 242 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI---PEIKTHS 276 Y+K + + P ++ IS + LI R F + RI EIK++S Sbjct: 243 SETPQETYKKVMN--WKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGAPGVEEIKSNS 299 Query: 277 WF 278 +F Sbjct: 300 FF 301 >2VD5-A nrPDB Length = 412 Score = 238 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 120/304 (39%), Gaps = 23/304 (7%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----VQREIINHRSLRH 75 D ++ +K IG G F +++ K T ++ A+K + + D + + E + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHS 134 I + +L ++MEY GG+L + G R + ARF+ +++ + H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST--VGTPAYIAPEVLL-- 190 + HRD+K +N LLD +++ DFG +S VGTP Y++PE+L Sbjct: 181 LGYVHRDIKPDNILLD--RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAV 238 Query: 191 ----RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 G D W+ GV Y M G PF Y K + + + D+ Sbjct: 239 GGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEG- 297 Query: 247 ISPECCHLISRIFVADPATRI---SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPM 303 + E I R+ P TR+ + +TH +F L ++ F + Sbjct: 298 VPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGL---RDSVPPFTPDFEGA 353 Query: 304 QSLD 307 Sbjct: 354 TDTC 357 >3PPZ-A nrPDB Length = 309 Score = 238 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 121/272 (44%), Gaps = 22/272 (8%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN---VQREI 67 +D+P + + IG+G+FG VAVK + D E RE+ Sbjct: 32 MDIPWC----DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREV 85 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG---RFSEDEARFFFQQ 124 + LRHPNIV F + P +L+I+ EY S G LY + +G + E Sbjct: 86 AIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYD 145 Query: 125 LLSGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKSTVGTP 181 + G++Y H+ I HRDLK N L+D +K+CDFG S+ + KS GTP Sbjct: 146 VAKGMNYLHNRNPPIVHRDLKSPNLLVDKK--YTVKVCDFGLSRLKASTFLSSKSAAGTP 203 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 ++APEVL + + K +DV+S GV L+ + P+ + + + ++ Sbjct: 204 EWMAPEVLRDEPSNEK-SDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIP- 261 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIK 273 ++P+ +I + +P R S I Sbjct: 262 ---RNLNPQVAAIIEGCWTNEPWKRPSFATIM 290 >6CQF-A nrPDB Length = 297 Score = 238 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 122/260 (46%), Gaps = 7/260 (2%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPNI 78 D YD ++ +G G +G RDK++ +LVA+K ++ D +Q+EI+ ++ RH NI Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANI 75 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 V + L L I ME+ G L + G SE + + +++L G++Y HS + Sbjct: 76 VAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKI 135 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK-STVGTPAYIAPEV--LLRQEYD 195 HRD+K N L+ + A +++ DFG S + + +GTP ++APEV + + Sbjct: 136 HRDIKGANILI--NDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 ++ D+WS G+T + P D P + + + + + S + I Sbjct: 194 NELCDIWSLGITAIELAELQPPLFDVH-PLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFI 252 Query: 256 SRIFVADPATRISIPEIKTH 275 P R S ++ +H Sbjct: 253 KVTLTKSPKKRPSATKMLSH 272 >5UUU-A nrPDB Length = 547 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 134/301 (44%), Gaps = 19/301 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL------ 73 + + + IG G FG R T ++ A+K +++ + + +N R + Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 257 Query: 74 -RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 P IV TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + Sbjct: 258 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 317 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 H+ + +RDLK N LLD ++I D G + +P ++VGT Y+APEVL + Sbjct: 318 HNRFVVYRDLKPANILLDEH--GHVRISDLGLA-CDFSKKKPHASVGTHGYMAPEVLQKG 374 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 AD +S G L+ +L G PF + +D + + L++ +PD SPE Sbjct: 375 VAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDS--FSPELR 431 Query: 253 HLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLD 307 L+ + D R+ E+K +F ++L ++ P + + D Sbjct: 432 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF-RSLDWQMVFLQKYPPPLIPPRGEVNAAD 490 Query: 308 T 308 Sbjct: 491 A 491 >3OZ6-A nrPDB Length = 388 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 77/331 (23%), Positives = 117/331 (35%), Gaps = 73/331 (22%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSL 73 H +Y+ VK +G G +G+ D+ T E+VAVK I + + QR EI+ L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 74 R-HPNIVRFKEVIL--TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 H NIV V+ + ++ +Y +L+ I A ++ QL+ + Sbjct: 66 SGHENIVNLLNVLRADNDRDVYLVFDYME-TDLHAVI-RANILEPVHKQYVVYQLIKVIK 123 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--------------------L 170 Y HS + HRD+K N LL+ +K+ DFG S+S V Sbjct: 124 YLHSGGLLHRDMKPSNILLNAE--CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 171 HSQP--KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYR 228 QP V T Y APE+LL K D+WS G L +L G F Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 229 KTIQRI-----------------------------------------LSVKYSIPDDIRI 247 + I I ++ I Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADC 301 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWF 278 + E L+ ++ +P RIS + H + Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPFV 332 >3PVW-A nrPDB Length = 695 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 134/301 (44%), Gaps = 19/301 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL------ 73 + + + IG G FG R T ++ A+K +++ + + +N R + Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 Query: 74 -RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 P IV TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + Sbjct: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 H+ + +RDLK N LLD ++I D G + +P ++VGT Y+APEVL + Sbjct: 309 HNRFVVYRDLKPANILLDEH--GHVRISDLGLA-CDFSKKKPHASVGTHGYMAPEVLQKG 365 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 AD +S G L+ +L G PF + +D + + L++ +PD SPE Sbjct: 366 VAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDS--FSPELR 422 Query: 253 HLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLD 307 L+ + D R+ E+K +F ++L ++ P + + D Sbjct: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF-RSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 Query: 308 T 308 Sbjct: 482 A 482 >6HXF-B nrPDB Length = 302 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 129/289 (44%), Gaps = 12/289 (4%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE-RGDKIDENVQREIINHRSLR 74 + ++ ++ V ++G G FG ++K T L A K IE + ++ E+ EI + Sbjct: 15 LDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCD 74 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCH 133 HP IV+ L I++E+ GG + + R +E + + +Q+L +++ H Sbjct: 75 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 134 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGY-SKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 S +I HRDLK N L+ + +++ DFG +K+ + S +GTP ++APEV++ + Sbjct: 135 SKRIIHRDLKAGNVLM--TLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 193 EY----DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 AD+WS G+TL M P E R ++ S ++ + S Sbjct: 193 TMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKIAKSDPPTLLTPSKWS 249 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQ 297 E + +P TR S ++ H + + E ++ + Sbjct: 250 VEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAE 298 >1JNK-A nrPDB Length = 423 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 127/341 (37%), Gaps = 58/341 (17%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRHP 76 RY +K IGSG G+ D + VA+K + R + + RE++ + + H Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 Query: 77 NIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 NI+ V L ++ME L + I + + Q+L G+ Sbjct: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIK 178 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Sbjct: 179 HLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI---------------- 234 Y + D+WS G + M+ F + + K I+++ Sbjct: 237 GMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Query: 235 -----------LSVKYSIPDDIR---------ISPECCHLISRIFVADPATRISIPEIKT 274 L+ PD + + + L+S++ V DPA RIS+ + Sbjct: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 Query: 275 HSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 H + + + P+ + LD I E Sbjct: 356 HPYI-------NVWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 >2H8H-A nrPDB Length = 535 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 109/294 (37%), Gaps = 19/294 (6%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ 64 P T G + +G G FG + T VA+K ++ G E Sbjct: 252 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL 310 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFF 122 +E + LRH +V+ V+ + + I+ EY S G L + + + Sbjct: 311 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 369 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP- 181 Q+ SG++Y M HRDL+ N L+ + K+ DFG ++ + ++ + G Sbjct: 370 AQIASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLAR-LIEDNEYTARQGAKF 426 Query: 182 --AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVK 238 + APE L + K +DVWS G+ L + G P+ + + Sbjct: 427 PIKWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERG 480 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIP--EIKTHSWFLKNLPADLMNES 290 Y +P L+ + + +P R + + +F P E+ Sbjct: 481 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 534 >4FR4-A nrPDB Length = 384 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 138/337 (40%), Gaps = 17/337 (5%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR----EIINHRSL 73 + D ++ ++ IG G+FG +++ TK++ A+KY+ + ++ N R E+ + L Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 HP +V + ++++ GG+L + F E+ + F +L+ + Y Sbjct: 73 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 132 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 + +I HRD+K +N LLD + I DF + +Q + GT Y+APE+ ++ Sbjct: 133 NQRIIHRDMKPDNILLDEH--GHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRK 190 Query: 194 --YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 D WS GVT Y +L G P+ ++ + + + P S E Sbjct: 191 GAGYSFAVDWWSLGVTAYELLRGRRPY-HIRSSTSSKEIVHTFETTVVTYP--SAWSQEM 247 Query: 252 CHLISRIFVADPATRIS-IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIM 310 L+ ++ +P R S + +++ + ++ D + + F P + + D Sbjct: 248 VSLLKKLLEPNPDQRFSQLSDVQNFPYMN-DINWDAVFQKRLIPGF-IPNKGRLNCDPTF 305 Query: 311 QIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSES 347 ++ + D S++ Sbjct: 306 ELEE---MILESKPLHKKKKRLAKKEKDMRKCDSSQT 339 >1TKI-A nrPDB Length = 321 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 122/266 (45%), Gaps = 8/266 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 ++Y +D+G G FG+ + +K+ K+++ V++EI RH NI+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNIL 64 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 E + L +I E+ SG +++ERI +A +E E + Q+ + + HS I Sbjct: 65 HLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIG 124 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 H D++ EN + + +KI +FG ++ + P Y APEV Sbjct: 125 HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVST-A 183 Query: 199 ADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECCHLIS 256 D+WS G +YV+L G PF ++ I+ I++ +Y+ ++ IS E + Sbjct: 184 TDMWSLGTLVYVLLSGINPF----LAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 257 RIFVADPATRISIPEIKTHSWFLKNL 282 R+ V + +R++ E H W + + Sbjct: 240 RLLVKERKSRMTASEALQHPWLKQKI 265 >6F3F-A nrPDB Length = 455 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 109/294 (37%), Gaps = 19/294 (6%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ 64 P T G + +G G FG + T VA+K ++ G E Sbjct: 172 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL 230 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFF 122 +E + LRH +V+ V+ + + I+ EY + G L + + + Sbjct: 231 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMS 289 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP- 181 Q+ SG++Y M HRDL+ N L+ + K+ DFG ++ + ++ + G Sbjct: 290 AQIASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLAR-LIEDNEYTARQGAKF 346 Query: 182 --AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVK 238 + APE L + K +DVWS G+ L + G P+ + + Sbjct: 347 PIKWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERG 400 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIP--EIKTHSWFLKNLPADLMNES 290 Y +P L+ + + +P R + + +F P E+ Sbjct: 401 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 454 >2WQN-A nrPDB Length = 310 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 66/258 (25%), Positives = 109/258 (42%), Gaps = 14/258 (5%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ----REIINHRSLRHP 76 + K IG G F L VA+K ++ D +D + +EI + L HP Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----FSEDEARFFFQQLLSGVSYC 132 N++++ + L I++E A G+L I + + E +F QL S + + Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-PKSTVGTPAYIAPEVLLR 191 HS ++ HRD+K N + + +K+ D G + + S VGTP Y++PE + Sbjct: 153 HSRRVMHRDIKPANVFITATGV--VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE 210 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 Y+ K +D+WS G LY M PF + + ++I Y S E Sbjct: 211 NGYNFK-SDIWSLGCLLYEMAALQSPFYGDK--MNLYSLCKKIEQCDYPPLPSDHYSEEL 267 Query: 252 CHLISRIFVADPATRISI 269 L++ DP R + Sbjct: 268 RQLVNMCINPDPEKRPDV 285 >3C51-A nrPDB Length = 543 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 122/291 (41%), Gaps = 24/291 (8%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLRHPNIVRF 81 + +G G FG + K T +L A K + + + E + IV Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLLSGVSYCHSMQI 137 T T L ++M +GG++ I N F E A F+ Q++SG+ + H I Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLRQEYDG 196 +RDLK EN LLD ++I D G + ++ K GTP ++APE+LL +EYD Sbjct: 311 IYRDLKPENVLLDDD--GNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDF 368 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 D ++ GVTLY M+ PF E + ++ QR+L + PD + SP Sbjct: 369 -SVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD--KFSPASKDFCE 425 Query: 257 RIFVADPATRISIPE-----IKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 + DP R+ + ++TH F D+ P P Sbjct: 426 ALLQKDPEKRLGFRDGSCDGLRTHPLFR-----DISWRQLEAGMLTPPFVP 471 >5ZTN-A nrPDB Length = 429 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 83/366 (22%), Positives = 121/366 (33%), Gaps = 77/366 (21%) Query: 3 RAPVTTGP------------LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAV 50 R +T GP + +P H + RY+ +K IG G+FG D + VA+ Sbjct: 68 RQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVAL 127 Query: 51 KYIERGDKIDENVQREIINHRSLRHP------NIVRFKEVILTPTHLAIIMEYASGGELY 104 K + + EI LR N++ E H+ + E S LY Sbjct: 128 KMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-NLY 186 Query: 105 ERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDF 162 E I FS R F +L + H +I H DLK EN LL +K+ DF Sbjct: 187 ELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDF 246 Query: 163 GYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE 222 G S H + + + + Y APEV+L Y G D+WS G L +L G + Sbjct: 247 GSS--CYEHQRVYTYIQSRFYRAPEVILGARY-GMPIDMWSLGCILAELLTGYPLLPGED 303 Query: 223 EPRDYRKTIQ--------------------------------------------RILSVK 238 E I+ R K Sbjct: 304 EGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGK 363 Query: 239 YSIPDDIR---------ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 P + R P + + DPA R++ + H W + LP E Sbjct: 364 LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGE 423 Query: 290 SNTGSQ 295 + + Sbjct: 424 KTSVKR 429 >3FI2-A nrPDB Length = 353 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 118/304 (38%), Gaps = 51/304 (16%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLRHP 76 RY +K IGSG G+ D + VA+K + R + + RE++ + + H Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 83 Query: 77 NIVRFKEVILTPTHL------AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 NI+ V L ++ME L + I + + Q+L G+ Sbjct: 84 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIK 140 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Sbjct: 141 HLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 198 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI---------------- 234 Y + D+WS G + M+ F + + K I+++ Sbjct: 199 GMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 257 Query: 235 -----------LSVKYSIPDDIR---------ISPECCHLISRIFVADPATRISIPEIKT 274 L+ PD + + + L+S++ V DPA RIS+ + Sbjct: 258 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 317 Query: 275 HSWF 278 H + Sbjct: 318 HPYI 321 >4UYA-A nrPDB Length = 340 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 79/275 (28%), Positives = 117/275 (42%), Gaps = 23/275 (8%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-----ENVQREII 68 P+ +R + + IG+G FG + VAVK + + D E+V+RE Sbjct: 20 PVHVAFERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREAR 77 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 LRHPNI+ + V L HL +++E+A GG L R R + Q+ G Sbjct: 78 LFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGAL-NRALAGRRIPPHVLVNWAVQIARG 136 Query: 129 VSYCHSMQ---ICHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPKSTVG 179 + Y H I HRDLK N LL D LKI DFG ++ ++ +T G Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM-ATAG 195 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 A++APEV+ + K +D+WS GV L+ +L G P+ D + K Sbjct: 196 AYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGI----DGLAVAYGVAVNKL 250 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 ++P L+ + DP R S I Sbjct: 251 TLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE 285 >5VO2-A nrPDB Length = 300 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 76/248 (30%), Positives = 112/248 (45%), Gaps = 15/248 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +GSG G L R E VAVK + + D I + R L+HPNI+ FK V Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD------IKHLRKLKHPNIITFKGVCTQ 71 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 I+ME+ + G+LYE + + + + G++Y H +I HRDLK N Sbjct: 72 APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNM 131 Query: 148 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVT 207 L+ +KI DFG SK S S GT A++APEV+ + K D+WS GV Sbjct: 132 LITYDDV--VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK-VDIWSFGVV 188 Query: 208 LYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRI 267 L+ +L G P++D + I + S +P L+ + + + P R Sbjct: 189 LWELLTGEIPYKDVDSSA----IIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 244 Query: 268 SIPEIKTH 275 S +I H Sbjct: 245 SFRQILLH 252 >4BGQ-A nrPDB Length = 304 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 77/300 (25%), Positives = 126/300 (42%), Gaps = 38/300 (12%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHR 71 I + ++++ + +G G +GV R K T E+VA+K + +++ E RE+ R Sbjct: 7 IGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR 66 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVS 130 +L+ NIV KE L ++ EY + E + ++ + + QL+ + Sbjct: 67 TLKQENIVELKEAFRRRGKLYLVFEYVEK-NMLELLEEMPNGVPPEKVKSYIYQLIKAIH 125 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL--HSQPKSTVGTPAYIAPEV 188 +CH I HRD+K EN L+ + LK+CDFG++++ ++ V T Y +PE+ Sbjct: 126 WCHKNDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYDEEVATRWYRSPEL 183 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK--------YS 240 LL Y GK D+WS G L + G F E D TIQ++L YS Sbjct: 184 LLGAPY-GKSVDMWSVGCILGELSDGQPLFPGESEI-DQLFTIQKVLGPLPSEQMKLFYS 241 Query: 241 IPDDIR-------------------ISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 P ++ L+ + DPA R + H F Sbjct: 242 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 301 >3MIA-A nrPDB Length = 351 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 136/333 (40%), Gaps = 49/333 (14%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREI 67 ++ P + +Y+ + IG G FG R + T + VA+K + + REI Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 68 INHRSLRHPNIVRFKEVILT--------PTHLAIIMEYASGGELYERICNA-GRFSEDEA 118 + L+H N+V E+ T + ++ ++ +L + N +F+ E Sbjct: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL-----HSQ 173 + Q LL+G+ Y H +I HRD+K N L+ LK+ DFG +++ L ++ Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV--LKLADFGLARAFSLAKNSQPNR 184 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRD------- 226 + V T Y PE+LL + G D+W G + M + + E Sbjct: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 Query: 227 ----------------YRKTIQRILSVKYSIPDDIRI---SPECCHLISRIFVADPATRI 267 + ++ + K + D ++ P LI ++ V DPA RI Sbjct: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 Query: 268 SIPEIKTHSWFLKN-LPADL--MNESNTGSQFQ 297 + H +F + +P+DL M ++ S F+ Sbjct: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 >5G6V-A nrPDB Length = 324 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 72/288 (25%), Positives = 120/288 (41%), Gaps = 31/288 (10%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVK--YIERGDKIDENVQREIINHRSLRHPN 77 + Y + +G G + + KLT LVA+K +E + RE+ + L+H N Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRF-SEDEARFFFQQLLSGVSYCHSMQ 136 IV ++I T L ++ EY +L + + + G + + F QLL G++YCH + Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 120 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 + HRDLK +N L++ LK+ DFG ++ S+ + V T Y P++LL Sbjct: 121 VLHRDLKPQNLLINE--RGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ-----------RILSVK----YS 240 D+W G Y M G F + ILS + Y+ Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 241 IPDD---------IRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 P R+ + L++++ + RIS + H +FL Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFL 286 >4GS6-A nrPDB Length = 315 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 81/270 (30%), Positives = 122/270 (45%), Gaps = 21/270 (7%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 M D + + +G G FGV + + + VA+K IE + + E+ + Sbjct: 4 HMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE-SESERKAFIVELRQLSRVN 60 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFS---EDEARFFFQQLLSGVSY 131 HPNIV+ L P + ++MEYA GG LY + A A + Q GV+Y Sbjct: 61 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 118 Query: 132 CHSMQ---ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 HSMQ + HRDLK N LL + LKICDFG + + + + G+ A++APEV Sbjct: 119 LHSMQPKALIHRDLKPPNLLL-VAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEV 175 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 Y K DV+S G+ L+ ++ PF++ P I + P + Sbjct: 176 FEGSNYSEK-CDVFSWGIILWEVITRRKPFDEIGGPAF---RIMWAVHNGTRPPLIKNLP 231 Query: 249 PECCHLISRIFVADPATRISIPE---IKTH 275 L++R + DP+ R S+ E I TH Sbjct: 232 KPIESLMTRCWSKDPSQRPSMEEIVKIMTH 261 >5SYS-A nrPDB Length = 286 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 19/292 (6%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQRE 66 T G + +G G FG + T VA+K ++ G E +E Sbjct: 5 TQGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFLQE 63 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA--GRFSEDEARFFFQQ 124 + LRH +V+ V+ + + I+ EY S G L + + + Q Sbjct: 64 AQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQ 122 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 181 + SG++Y M HRDL+ N L+ + K+ DFG ++ + ++ + G Sbjct: 123 IASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLAR-LIEDNEYTARQGAKFPI 179 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYS 240 + APE L + K +DVWS G+ L + G P+ + + Y Sbjct: 180 KWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ-----VERGYR 233 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIP--EIKTHSWFLKNLPADLMNES 290 +P L+ + + DP R + + +F P E+ Sbjct: 234 MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 285 >4NST-A nrPDB Length = 351 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 125/319 (39%), Gaps = 58/319 (18%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHP 76 D++D + IG G +G +DK T ELVA+K + + REI R L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 77 NIVRFKEVILTPTH----------LAIIMEYASGGELYERICNA-GRFSEDEARFFFQQL 125 ++V KE++ ++ EY +L + + FSED + F +QL Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 183 + G+ YCH HRD+K N LL+ S ++K+ DFG ++ +S + V T Y Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNS--GQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY---------------- 227 PE+LL +E DVWSCG L + F+ E Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 228 -------------RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 +K +R L ++S I L+ + DP+ R + + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSF-----IPSAALDLLDHMLTLDPSKRCTAEQTLQ 304 Query: 275 HSWFL-----KNLPADLMN 288 + K P DL + Sbjct: 305 SDFLKDVELSKMAPPDLPH 323 >4UY9-A nrPDB Length = 323 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 79/270 (29%), Positives = 118/270 (43%), Gaps = 23/270 (8%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-----ENVQREIINHRS 72 D + IG G FG + VAVK D ENV++E Sbjct: 7 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 64 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 L+HPNI+ + V L +L ++ME+A GG L R+ + R D + Q+ G++Y Sbjct: 65 LKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 133 HSMQ---ICHRDLKLENTLL-----DGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAY 183 H I HRDLK N L+ +G + ++ KI DFG ++ ++ S GT A+ Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGTYAW 182 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +APEV+ + K +DVWS GV L+ +L G PF D + K ++P Sbjct: 183 MAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGI----DGLAVAYGVAMNKLALPI 237 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIK 273 L+ + DP +R S I Sbjct: 238 PSTCPEPFAKLMEDCWNPDPHSRPSFTNIL 267 >4E7W-A nrPDB Length = 394 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 125/317 (39%), Gaps = 39/317 (12%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 Y K IG+G+FGV + + E VA+K + + + RE+ R ++HPN+V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFK---NRELQIMRIVKHPNVVDL 97 Query: 82 KEVILTPTH------LAIIMEYAS---GGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 K + L +++EY + + QLL ++Y Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HS+ ICHRD+K +N LLD P+ LK+ DFG +K + S + + Y APE++ Sbjct: 158 HSIGICHRDIKPQNLLLDP-PSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGA 216 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQ-------------------- 232 D+WS G + ++ G F + I+ Sbjct: 217 TNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEH 276 Query: 233 ---RILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF--LKNLPADLM 287 +I +S R P+ LISR+ P+ R++ E H +F L+ A + Sbjct: 277 KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGEARMP 336 Query: 288 NESNTGSQFQEPEQPMQ 304 N F ++ + Sbjct: 337 NGRELPPLFNWTKEELS 353 >4O2Z-A nrPDB Length = 377 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 117/307 (38%), Gaps = 42/307 (13%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDEN 62 V+ P ++P +Y +K +G G +G+A D T E V++K R + + Sbjct: 36 VSGSPFEVPS-----KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 63 VQREIINHRSLRHPNIVR-------FKEVILTPTHLAIIMEYASGGELYERICNAGRFSE 115 V REI R H N++ K + + ++ ++ + + E Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDV-DMNVVLRSRQVLEE 149 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQP 174 ++F Q+L G+ Y HS + HRDLK N + + + LKI DFG S+S V +S+ Sbjct: 150 SHMQYFVYQILRGLKYLHSANVAHRDLKPANLV--TNISCELKIIDFGLSRSVDVPYSEL 207 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 V T Y PE+LL D+WS G M F R Q I Sbjct: 208 TDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHI 267 Query: 235 LSVKYSIPDDIRI-----------------------SPECCHLISRIFVADPATRISIPE 271 SI + + E +S+++ DP+ R + + Sbjct: 268 GKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAAD 327 Query: 272 IKTHSWF 278 + H + Sbjct: 328 MLAHPYL 334 >5EFQ-A nrPDB Length = 347 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 125/325 (38%), Gaps = 55/325 (16%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHP 76 D++D + IG G +G RDK T E+VA+K + + REI R L H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 77 NIVRFKEVILTPTH----------LAIIMEYASGGELYERICNA-GRFSEDEARFFFQQL 125 +I+ KE++ ++ EY +L + + F+E+ + F +QL Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFMRQL 129 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAY 183 + G+ YCH HRD+K N LL+ ++K+ DFG ++ SS + V T Y Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNN--RGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK----- 238 PE+LL +E DVWSCG L + F+ +E + I RI Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE-LAQLELISRICGSPCPAVW 246 Query: 239 ---YSIP-----------------DDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 +P + + I L + DP+ R + + + Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL 306 Query: 279 LKNLPADLMNESNTGSQFQEPEQPM 303 S+ P+ P+ Sbjct: 307 ----------RDVEPSKMPPPDLPL 321 >4X7Q-B nrPDB Length = 312 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 79/287 (27%), Positives = 119/287 (41%), Gaps = 26/287 (9%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR-------EIINHRSL 73 Y +G G FG + VA+K I R + + E+ + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 74 R----HPNIVRFKEVILTPTHLAIIMEY-ASGGELYERICNAGRFSEDEARFFFQQLLSG 128 HP ++R + T +++E +L++ I G E +R FF Q+++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 + +CHS + HRD+K EN L+D K+ DFG S + + GT Y PE Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLR-RGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEW 209 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + R +Y A VWS G+ LY M+ G PFE +E IL + P +S Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE----------ILEAELHFP--AHVS 257 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQ 295 P+CC LI R P++R S+ EI W +N S G Sbjct: 258 PDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPA 304 >3DTC-A nrPDB Length = 271 Score = 230 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 78/270 (28%), Positives = 117/270 (43%), Gaps = 23/270 (8%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-----ENVQREIINHRS 72 D + IG G FG + VAVK D ENV++E Sbjct: 5 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 62 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 L+HPNI+ + V L +L ++ME+A GG L R+ + R D + Q+ G++Y Sbjct: 63 LKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 133 HSMQ---ICHRDLKLENTLL-----DGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAY 183 H I HRDLK N L+ +G + ++ KI DFG ++ ++ S G A+ Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGAYAW 180 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +APEV+ + K +DVWS GV L+ +L G PF D + K ++P Sbjct: 181 MAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGI----DGLAVAYGVAMNKLALPI 235 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIK 273 L+ + DP +R S I Sbjct: 236 PSTCPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >5H2U-A nrPDB Length = 267 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 104/263 (39%), Gaps = 14/263 (5%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR-EIINHRSLRH 75 + + + +GSG FG K + VA+K I R + + + + + EI + LRH Sbjct: 3 RPREEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 61 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCH 133 +I+ V+ + II E + G L E + + E Q+ G+ Y Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-YIAPEVLLRQ 192 S HRDL N L+ + K+ DFG ++ P + APE L R Sbjct: 122 SQNYIHRDLAARNILVGEN--TLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRG 179 Query: 193 EYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 Y K +DVWS G+ L+ M G P+ + + + Y +P + P Sbjct: 180 HYSTK-SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR-----VDAGYRMPCPLECPPSV 233 Query: 252 CHLISRIFVADPATRISIPEIKT 274 L+ + DP R + ++ Sbjct: 234 HKLMLTCWCRDPEQRPTFKALRE 256 >5TUR-A nrPDB Length = 404 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 82/291 (28%), Positives = 125/291 (42%), Gaps = 24/291 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-------NVQREIINHRSL 73 +Y +GSG FG VA+K++E+ D V E++ + + Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 74 RHPN--IVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSGVS 130 ++R + P +I+E +L++ I G E+ AR FF Q+L V Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 247 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 +CH+ + HRD+K EN L+D + LK+ DFG S + + + GT Y PE + Sbjct: 248 HCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 305 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Y G+ A VWS G+ LY M+ G PFE EE + ++ R+S E Sbjct: 306 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------------RVSSE 353 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 C HLI P+ R + EI+ H W L E + S P + Sbjct: 354 CQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 404 >4EBW-A nrPDB Length = 304 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 66/263 (25%), Positives = 115/263 (43%), Gaps = 18/263 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIER--GDKIDENVQREIINHRSLR 74 +R + + IG G FG + VA+K + D + E +E + R Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCH 133 HP+IV+ VI T + IIME + GEL + + QL + ++Y Sbjct: 98 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLE 156 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLR 191 S + HRD+ N L+ + +K+ DFG S+ + K++ G ++APE + Sbjct: 157 SKRFVHRDIAARNVLVSSNDC--VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 214 Query: 192 QEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 + + +DVW GV ++ +L+ G PF+ + I RI + + +P P Sbjct: 215 RRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNND----VIGRIENGE-RLPMPPNCPPT 268 Query: 251 CCHLISRIFVADPATRISIPEIK 273 L+++ + DP+ R E+K Sbjct: 269 LYSLMTKCWAYDPSRRPRFTELK 291 >4RC3-A nrPDB Length = 289 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 84/303 (27%), Positives = 127/303 (41%), Gaps = 24/303 (7%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE------- 61 GP +Y +GSG FG VA+K++E+ D Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 62 NVQREIINHRSLRHPN--IVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEA 118 V E++ + + ++R + P +I+E +L++ I G E+ A Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 120 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 R FF Q+L V +CH+ + HRD+K EN L+D + LK+ DFG S + + + Sbjct: 121 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFD 178 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 GT Y PE + Y G+ A VWS G+ LY M+ G PFE EE + ++ Sbjct: 179 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ----- 233 Query: 239 YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQE 298 R+S EC HLI P+ R + EI+ H W L E + S Sbjct: 234 -------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPG 286 Query: 299 PEQ 301 P + Sbjct: 287 PSK 289 >3BGP-A nrPDB Length = 333 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 82/291 (28%), Positives = 125/291 (42%), Gaps = 24/291 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE-------NVQREIINHRSL 73 +Y +GSG FG VA+K++E+ D V E++ + + Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 74 RHPN--IVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSGVS 130 ++R + P +I+E +L++ I G E+ AR FF Q+L V Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 176 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 +CH+ + HRD+K EN L+D + LK+ DFG S + + + GT Y PE + Sbjct: 177 HCHNCGVLHRDIKDENILIDLN-RGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 234 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Y G+ A VWS G+ LY M+ G PFE EE + ++ R+S E Sbjct: 235 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------------RVSSE 282 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 C HLI P+ R + EI+ H W L E + S P + Sbjct: 283 CQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 333 >3M42-A nrPDB Length = 299 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 138/310 (44%), Gaps = 39/310 (12%) Query: 20 DRYDFV-KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHPN 77 D Y + +G G G + +K T+E A+K ++ K +RE+ H R+ + P+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 72 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 IVR +V L I+ME GGEL+ RI + G F+E EA + + + Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 132 CHSMQICHRDLKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 HS+ I HRD+K EN L P LK+ DFG++K + Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------------- 171 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRIS 248 ++YD K D+WS GV +Y++L G PF KT R+ ++ P+ +S Sbjct: 172 GEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 230 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 E LI + +P R++I E H W +++ +T +E ++ + + Sbjct: 231 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ-TPLHTSRVLKEDKERWEDVKE 289 Query: 309 IMQIISEATI 318 M + AT+ Sbjct: 290 EM-TSALATM 298 >4OTD-A nrPDB Length = 341 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 28/296 (9%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR----- 74 + + F+ +G G+FG L + + EL A+K +++GD + + ++ + + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 75 --HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 HP +V TP H+ +MEY++GG+L I + FSE A F+ ++ G+ + Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 130 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLR 191 H +I +RDLKL+ L +KI DFG K + + ST GTP ++APEVL Sbjct: 131 HEHKIVYRDLKLD--NLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 Y + D W GV LY MLVG PF +E + I++ + P +S E Sbjct: 189 TSYT-RAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF--LSAEA 241 Query: 252 CHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQP 302 ++ R+ +P R+ ++K +F L E+ + P P Sbjct: 242 IGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRT-----LGWEALLARRLPPPFVP 292 >4P5Q-A nrPDB Length = 361 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 108/266 (40%), Gaps = 19/266 (7%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRS 72 D+ K +G+G FG R KL + VA+K ++ G +K + E Sbjct: 31 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQ 90 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSY 131 HPNI+R + V+ + I+ EY G L + +F+ + + + SG+ Y Sbjct: 91 FDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKY 150 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPE 187 M HRDL N L++ + K+ DFG S+ + + G + +PE Sbjct: 151 LSDMGYVHRDLAARNILINSNLV--CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPE 208 Query: 188 VLLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 + +++ +DVWS G+ L+ M G P+ + + + + + Y +P + Sbjct: 209 AIAYRKFTS-ASDVWSYGIVLWEVMSYGERPYWEMSN-----QDVIKAVDEGYRLPPPMD 262 Query: 247 ISPECCHLISRIFVADPATRISIPEI 272 L+ + D R +I Sbjct: 263 CPAALYQLMLDCWQKDRNNRPKFEQI 288 >5X5O-A nrPDB Length = 310 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 119/269 (44%), Gaps = 20/269 (7%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREII 68 G + D F ++ G G+FG + + VAVK + + +++E Sbjct: 4 GSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAE 56 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLL 126 L H NI++F VIL P + I+ EYAS G LY+ I + D + + Sbjct: 57 ILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVA 116 Query: 127 SGVSYCHSM---QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 G+ Y H ++ HRDLK N ++ LKICDFG S+ H+ S VGT + Sbjct: 117 KGMHYLHMEAPVKVIHRDLKSRNVVIAADGV--LKICDFGASRFHN-HTTHMSLVGTFPW 173 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +APEV+ + D +S GV L+ ML PF+ E + +++ + + +IP Sbjct: 174 MAPEVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK--NERLTIPS 230 Query: 244 DIRISPECCHLISRIFVADPATRISIPEI 272 L+ + + AD R S +I Sbjct: 231 S--CPRSFAELLHQCWEADAKKRPSFKQI 257 >2W96-B nrPDB Length = 306 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 113/297 (38%), Gaps = 38/297 (12%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---NVQREIINHRSLR- 74 + RY+ V +IG G +G RD + VA+K + + + + RE+ R L Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 75 --HPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQL 125 HPN+VR +V T + ++ E+ +L + A + + +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 L G+ + H+ I HRDLK EN L+ +K+ DFG ++ V T Y A Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALDPVVVTLWYRA 179 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYSIPDD 244 PEVLL+ Y D+WS G M F E K I L + P D Sbjct: 180 PEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 238 Query: 245 IRIS--------------------PECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 + + L+ + +P RIS HS+ K+ Sbjct: 239 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 295 >4AN9-A nrPDB Length = 301 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 122/265 (46%), Gaps = 11/265 (4%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D ++ + ++G+GN GV + K + ++A K I E I + RE+ P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 68 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HSMQ 136 IV F + ++I ME+ GG L + + AGR E ++ G++Y + Sbjct: 69 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 128 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I HRD+K N L++ +K+CDFG S + VGT +Y++PE L Y Sbjct: 129 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DEMANEFVGTRSYMSPERLQGTHYSV 185 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 + +D+WS G++L M VG YP P + + I++ S E ++ Sbjct: 186 Q-SDIWSMGLSLVEMAVGRYP----RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVN 240 Query: 257 RIFVADPATRISIPEIKTHSWFLKN 281 + + +PA R + ++ H++ ++ Sbjct: 241 KCLIKNPAERADLKQLMVHAFIKRS 265 >4Y93-A nrPDB Length = 446 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 114/280 (40%), Gaps = 17/280 (6%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-VAVKYIERGDKI 59 + AP T G D F+K++G+G FGV + K + VA+K I+ G Sbjct: 169 LAAAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMS 226 Query: 60 DENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEA 118 ++ E +L H +V+ V + II EY + G L + RF + Sbjct: 227 EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQL 286 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 + + + Y S Q HRDL N L++ +K+ DFG ++ VL + S+ Sbjct: 287 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGMTR-YVLDDEYTSST 343 Query: 179 GTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRI 234 G+ + +PEVL+ ++ K +D+W+ GV ++ + G P+E Q + Sbjct: 344 GSKFPVKWASPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 402 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 +P S ++ + R + + + Sbjct: 403 -----RLPRPHLASERVYAIMYSCWHEKADERPTFKILLS 437 >6DBM-A nrPDB Length = 318 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 77/286 (26%), Positives = 123/286 (43%), Gaps = 29/286 (10%) Query: 8 TGPLDMPIMHDSDRY-DFVKDIGSGNFGVARLM----RDKLTKELVAVKYIER--GDKID 60 GP D + H RY ++D+G G+FG L + T E+VAVK ++ G + Sbjct: 20 QGPGDPTVFH--KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR 77 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEA 118 ++EI R+L H +I+++K L ++MEY G L + + + Sbjct: 78 SGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQL 136 Query: 119 RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 F QQ+ G++Y HS HRDL N LLD +KI DFG +K+ + Sbjct: 137 LLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVR 194 Query: 179 ----GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG-----AYP--FEDPEEPRDY 227 + APE L ++ +DVWS GVTLY +L + P F + Sbjct: 195 EDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQG 253 Query: 228 RKTIQR---ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 + T+ R +L +P + E HL+ + + + R + Sbjct: 254 QMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFE 299 >2DQ7-X nrPDB Length = 283 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 112/284 (39%), Gaps = 19/284 (6%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + +K +G+G FG + VA+K ++ G E+ E + L+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK 62 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFFQQLLSGVSYC 132 H +V+ V+ + + I+ EY + G L + + Q+ +G++Y Sbjct: 63 HDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 121 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVL 189 M HRDL+ N L+ KI DFG ++ + ++ + G + APE Sbjct: 122 ERMNYIHRDLRSANILVGN--GLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAA 178 Query: 190 LRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 L + K +DVWS G+ L ++ G P+ R+ ++++ Y +P Sbjct: 179 LYGRFTIK-SDVWSFGILLTELVTKGRVPYPGMNN----REVLEQV-ERGYRMPCPQDCP 232 Query: 249 PECCHLISRIFVADPATRISIPEIKT--HSWFLKNLPADLMNES 290 L+ + DP R + +++ +F P E+ Sbjct: 233 ISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGEN 276 >5MJB-A nrPDB Length = 305 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 106/265 (40%), Gaps = 21/265 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKE---LVAVKYIERG--DKIDENVQREIINHRSLRHPN 77 + IG+G FG R KL + VA+K ++ G +K + E H N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + V+ + II E+ L + N G+F+ + + + +G+ Y M Sbjct: 89 IIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 190 HRDL N L++ + K+ DFG S+ + + + + APE + Sbjct: 149 YVHRDLAARNILVNSNLV--CKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA 206 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++ +DVWS G+ ++ M G P+ D + + + Y +P + Sbjct: 207 YRKFTS-ASDVWSYGIVMWEVMSFGERPYWDMSN-----QDVINAIEQDYRLPPPMDCPA 260 Query: 250 ECCHLISRIFVADPATRISIPEIKT 274 L+ + D +R EI Sbjct: 261 ALHQLMLDCWQKDRNSRPRFAEIVN 285 >4YHJ-A nrPDB Length = 584 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 125/313 (39%), Gaps = 32/313 (10%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI- 59 ++R PVT + + + +G G FG + + T ++ A K +++ Sbjct: 177 LERQPVTK-----------NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKK 225 Query: 60 ---DENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FS 114 + E ++ +V T L +++ +GG+L I N G F Sbjct: 226 RKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 E A F+ +L G+ +I +RDLK EN LLD ++I D G + + Sbjct: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD--DRGHIRISDLGLATEIPEGQRV 343 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 + VGT Y+APEV+ ++Y D W G +Y M+ G PF+ +E + + QRI Sbjct: 344 RGRVGTVGYMAPEVVNNEKYTFSP-DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI 402 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNE 289 + + + S + + + +P+ R+ +K H F D+ Sbjct: 403 KNDTEEYSE--KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFK-----DINFR 455 Query: 290 SNTGSQFQEPEQP 302 + + P P Sbjct: 456 RLEANMLEPPFCP 468 >1JPA-A nrPDB Length = 312 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 105/265 (39%), Gaps = 21/265 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPN 77 + IG+G FG KL + VA+K ++ G +K + E HPN Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 ++ + V+ T + II E+ G L + N G+F+ + + + +G+ Y M Sbjct: 96 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMN 155 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG------TPAYIAPEVLL 190 HRDL N L++ + K+ DFG S+ + + + APE + Sbjct: 156 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 213 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++ +DVWS G+ ++ M G P+ D + + + Y +P + Sbjct: 214 YRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMTN-----QDVINAIEQDYRLPPPMDCPS 267 Query: 250 ECCHLISRIFVADPATRISIPEIKT 274 L+ + D R +I Sbjct: 268 ALHQLMLDCWQKDRNHRPKFGQIVN 292 >2J0K-A nrPDB Length = 656 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 66/263 (25%), Positives = 115/263 (43%), Gaps = 18/263 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIER--GDKIDENVQREIINHRSLR 74 +R + + IG G FG + VA+K + D + E +E + R Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCH 133 HP+IV+ VI T + IIME + GEL + + QL + ++Y Sbjct: 450 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLE 508 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLR 191 S + HRD+ N L+ + +K+ DFG S+ + K++ G ++APE + Sbjct: 509 SKRFVHRDIAARNVLVSATDC--VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINF 566 Query: 192 QEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 + + +DVW GV ++ +L+ G PF+ + I RI + + +P P Sbjct: 567 RRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNND----VIGRIENGE-RLPMPPNCPPT 620 Query: 251 CCHLISRIFVADPATRISIPEIK 273 L+++ + DP+ R E+K Sbjct: 621 LYSLMTKCWAYDPSRRPRFTELK 643 >1FVR-A nrPDB Length = 327 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 104/286 (36%), Gaps = 31/286 (10%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELV--AVKYIER--GDKIDENVQR 65 P P++ D + F IG GNFG R K + A+K ++ + Sbjct: 16 PTIYPVL-DWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG 74 Query: 66 EIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG------------- 111 E+ L HPNI+ +L + +EYA G L + + + Sbjct: 75 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS 134 Query: 112 ---RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS 168 S + F + G+ Y Q HRDL N L+ + KI DFG S+ Sbjct: 135 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA--KIADFGLSRGQ 192 Query: 169 VLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDY 227 ++ + ++A E L Y +DVWS GV L+ ++ G P+ Y Sbjct: 193 EVYVKKTMGRLPVRWMAIESLNYSVYTT-NSDVWSYGVLLWEIVSLGGTPYCGMTCAELY 251 Query: 228 RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 K L Y + + E L+ + + P R S +I Sbjct: 252 EK-----LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >3QGY-A nrPDB Length = 286 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 70/274 (25%), Positives = 116/274 (42%), Gaps = 17/274 (6%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR 65 V G L M I D FV++IGSG FG+ L L K+ VA+K I+ G +++ Sbjct: 15 VPRGSLHMVI--DPSELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIKEGSMSEDDFIE 71 Query: 66 EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQ 124 E L HP +V+ V L + ++ E+ G L + + G F+ + Sbjct: 72 EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLD 131 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 181 + G++Y + HRDL N L+ + +K+ DFG ++ VL Q S+ GT Sbjct: 132 VCEGMAYLEEACVIHRDLAARNCLVGENQV--IKVSDFGMTR-FVLDDQYTSSTGTKFPV 188 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYS 240 + +PEV Y K +DVWS GV ++ + G P+E+ S + Sbjct: 189 KWASPEVFSFSRYSSK-SDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI-----STGFR 242 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + S +++ + P R + + Sbjct: 243 LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLR 276 >4U41-A nrPDB Length = 332 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 116/271 (42%), Gaps = 20/271 (7%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPNIVR 80 ++ V+ +G+G +G R T +L A+K ++ + +E ++ EI + H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 81 FKEVIL------TPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYC 132 + + L ++ME+ G + + + N ED + +++L G+++ Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLR 191 H + HRD+K +N LL + +K+ DFG S + + +GTP ++APEV+ Sbjct: 146 HIHHVIHRDIKGQNVLLTEN--AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 203 Query: 192 QEY----DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 E +D+WSCG+T M GA P D R + I + Sbjct: 204 DENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRA----LFLIPRNPPPRLKSKKW 259 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWF 278 S + I V + R S ++ H + Sbjct: 260 SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 290 >5L6P-A nrPDB Length = 298 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 104/265 (39%), Gaps = 21/265 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPN 77 + IG+G FG R K VA+K ++ G ++ + E HPN Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + V+ + I+ E+ L + N G+F+ + + + +G+ Y M Sbjct: 82 IIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMN 141 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 190 HRDL N L++ + K+ DFG S+ + + + APE + Sbjct: 142 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA 199 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++ +DVWS G+ ++ M G P+ D + + + Y +P + Sbjct: 200 YRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSN-----QDVINAVEQDYRLPPPMDCPT 253 Query: 250 ECCHLISRIFVADPATRISIPEIKT 274 L+ +V D R +I Sbjct: 254 ALHQLMLDCWVRDRNLRPKFSQIVN 278 >3DKO-A nrPDB Length = 318 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 59/261 (22%), Positives = 109/261 (41%), Gaps = 19/261 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPN 77 + IG+G FG R KL + VA+K ++ G +K + E HPN Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSMQ 136 +V + V+ + I++E+ G L + G+F+ + + + +G+ Y M Sbjct: 106 VVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMG 165 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTP---AYIAPEVLLRQ 192 HRDL N L++ + K+ DFG S+ + +T G + APE + + Sbjct: 166 YVHRDLAARNILVNSNLV--CKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYR 223 Query: 193 EYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 ++ +DVWS G+ ++ M G P+ D + + + + Y +P + Sbjct: 224 KFTS-ASDVWSYGIVMWEVMSYGERPYWDMSN-----QDVIKAIEEGYRLPAPMDCPAGL 277 Query: 252 CHLISRIFVADPATRISIPEI 272 L+ + + A R +I Sbjct: 278 HQLMLDCWQKERAERPKFEQI 298 >2I6L-A nrPDB Length = 320 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 114/303 (37%), Gaps = 46/303 (15%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHPN 77 RY +K +G G G+ D + VA+K I D ++ REI R L H N Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDN 69 Query: 78 IVRFK--------------EVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 IV+ + + I+ EY +L + G E+ AR F Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVL-EQGPLLEEHARLFMY 127 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----G 179 QLL G+ Y HS + HRDLK N ++ + LKI DFG ++ H K + Sbjct: 128 QLLRGLKYIHSANVLHRDLKPANLFIN-TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 T Y +P +LL K D+W+ G ML G F E + ++ I V Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHE 246 Query: 240 S--------IPDDIR----------------ISPECCHLISRIFVADPATRISIPEIKTH 275 IP IR IS E + +I P R++ E +H Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSH 306 Query: 276 SWF 278 + Sbjct: 307 PYM 309 >1U5R-A nrPDB Length = 348 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 125/296 (42%), Gaps = 22/296 (7%) Query: 3 RAPVTTGP--LDMPIMHDSDR-YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI 59 RA P ++ D ++ + +++IG G+FG RD E+VA+K + K Sbjct: 34 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 93 Query: 60 D----ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFS 114 +++ +E+ + LRHPN ++++ L ++MEY G + + + Sbjct: 94 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQ 152 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 E E L G++Y HS + HRD+K N LL S +K+ DFG + Sbjct: 153 EVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILL--SEPGLVKLGDFGSASIMAP---A 207 Query: 175 KSTVGTPAYIAPEVLL---RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 S VGTP ++APEV+L +YDGK DVWS G+T + P + + Sbjct: 208 NSFVGTPYWMAPEVILAMDEGQYDGK-VDVWSLGITCIELAERKPPLFNMNA----MSAL 262 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLM 287 I + S + + P R + + H + L+ P ++ Sbjct: 263 YHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVI 318 >2HK5-A nrPDB Length = 270 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 111/266 (41%), Gaps = 17/266 (6%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLM-RDKLTKELVAVKYIERGDKIDENVQREIINHRSL 73 + K +G+G FG + +K TK VAVK ++ G E E ++L Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMSVEAFLAEANVMKTL 67 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSY 131 +H +V+ V+ T + II E+ + G L + + + + + F Q+ G+++ Sbjct: 68 QHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 126 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVL 189 HRDL+ N L+ S KI DFG ++ ++ + + APE + Sbjct: 127 IEQRNYIHRDLRAANILVSASLV--CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI 184 Query: 190 LRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + K +DVWS G+ L ++ G P+ P + R L Y +P Sbjct: 185 NFGSFTIK-SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRALERGYRMPRPENCP 238 Query: 249 PECCHLISRIFVADPATRISIPEIKT 274 E +++ R + P R + I++ Sbjct: 239 EELYNIMMRCWKNRPEERPTFEYIQS 264 >2Y6O-A nrPDB Length = 291 Score = 223 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 107/263 (40%), Gaps = 19/263 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPN 77 K IG G FG R K+ + VA+K ++ G DK + E HPN Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+ + V+ + II EY G L + N GRF+ + + + SG+ Y M Sbjct: 77 IIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMS 136 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPEVLLRQ 192 HRDL N L++ + K+ DFG S+ + + G + APE + + Sbjct: 137 YVHRDLAARNILVNSNLV--CKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR 194 Query: 193 EYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 ++ +DVWS G+ ++ M G P+ D + + + + Y +P + Sbjct: 195 KFTS-ASDVWSYGIVMWEVMSYGERPYWDMSN-----QDVIKAIEEGYRLPPPMDCPIAL 248 Query: 252 CHLISRIFVADPATRISIPEIKT 274 L+ + + + R +I Sbjct: 249 HQLMLDCWQKERSDRPKFGQIVN 271 >2XNP-A nrPDB Length = 279 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 82/279 (29%), Positives = 129/279 (46%), Gaps = 25/279 (8%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQR---EIINHRSLR 74 ++ Y+ + IG+G++G + +R K +++ K ++ G + Q E+ R L+ Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 75 HPNIVRFKE--VILTPTHLAIIMEYASGGELYERI----CNAGRFSEDEARFFFQQLLSG 128 HPNIVR+ + + T T L I+MEY GG+L I E+ QL Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 129 VSYCHS-----MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPA 182 + CH + HRDLK N LDG +K+ DFG ++ S K+ VGTP Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQ--NVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY-SI 241 Y++PE + R Y+ K +D+WS G LY + PF ++ +I K+ I Sbjct: 182 YMSPEQMNRMSYNEK-SDIWSLGCLLYELCALMPPF----TAFSQKELAGKIREGKFRRI 236 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 P R S E +I+R+ R S+ EI + L+ Sbjct: 237 P--YRYSDELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >4CRS-A nrPDB Length = 341 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 84/347 (24%), Positives = 146/347 (42%), Gaps = 27/347 (7%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL- 73 + + + G+FG L K T E+ A+K +++GD + + ++ + + Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIF 66 Query: 74 ------RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLS 127 RHP +V T H+ +MEYA+GG+L I + FSE A F+ ++ Sbjct: 67 ETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVL 125 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAP 186 G+ Y H +I +R L+ L +KI DFG K + + ST GTP ++AP Sbjct: 126 GLQYLHEHKIVYR--DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 EVL Y + D W GV +Y MLVG PF +E + I++ + P Sbjct: 184 EVLTETSYT-RAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF-- 236 Query: 247 ISPECCHLISRIFVADPATRIS-----IPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 +S E ++ R+ +P R+ ++K H +F + LM++ Sbjct: 237 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPT--- 293 Query: 302 PMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESE 348 ++ + + E T A + + + + DFD ++ Sbjct: 294 -IRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIAD 339 >2GCD-A nrPDB Length = 309 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 122/285 (42%), Gaps = 20/285 (7%) Query: 12 DMPIMHDSDR-YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQRE 66 ++ D ++ + +++IG G+FG RD E+VA+K + K +++ +E Sbjct: 6 ELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKE 65 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQL 125 + + LRHPN ++++ L ++MEY G + + + E E Sbjct: 66 VRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGA 124 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 L G++Y HS + HRD+K N LL S +K+ DFG + S VGTP ++A Sbjct: 125 LQGLAYLHSHNMIHRDVKAGNILL--SEPGLVKLGDFGSASIMAP---ANSFVGTPYWMA 179 Query: 186 PEVLL---RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 PEV+L +YDGK DVWS G+T + P + + I + Sbjct: 180 PEVILAMDEGQYDGK-VDVWSLGITCIELAERKPPLFNMNA----MSALYHIAQNESPAL 234 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLM 287 S + + P R + + H + L+ P ++ Sbjct: 235 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVI 279 >3VN9-A nrPDB Length = 340 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIIN-HRSLRH 75 +D + + ++G G +GV MR + +++AVK I + + + ++ R++ Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYER----ICNAGRFSEDEARFFFQQLLSGVSY 131 P V F + + I ME L + I ED ++ + + Sbjct: 110 PFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 Query: 132 CHSM-QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 189 HS + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 169 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L Q+ +D+WS G+T+ + + +P++ P K + + +P D + Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV--VEEPSPQLPAD-KF 283 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFL 279 S E S+ + R + PE+ H +F Sbjct: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >4XI2-A nrPDB Length = 446 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 112/277 (40%), Gaps = 17/277 (6%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-VAVKYIERGDKIDEN 62 AP T G D F+K++G+G FGV + K + VA+K I G ++ Sbjct: 171 APSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIREGSMSEDE 228 Query: 63 VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFF 121 E +L H +V+ V + II EY + G L + RF + Sbjct: 229 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEM 288 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 + + + Y S Q HRDL N L++ +K+ DFG S+ VL + S+VG+ Sbjct: 289 CKDVCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSK 345 Query: 182 ---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSV 237 + PEVL+ ++ K +D+W+ GV ++ + G P+E Q + Sbjct: 346 FPVRWSPPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLY 404 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + + S ++ + R S + + Sbjct: 405 RPHL-----ASERVYTIMYSCWHEKADERPSFKILLS 436 >2R2P-A nrPDB Length = 295 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 108/263 (41%), Gaps = 19/263 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPN 77 + IG+G FG R KL + VA+K ++ G +K + E HPN Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+ + V+ + I+ EY G L + G+F+ + + + +G+ Y M Sbjct: 85 IIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMG 144 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVG--TPAYIAPEVLLRQ 192 HRDL N L++ + K+ DFG S+ + + G + APE + + Sbjct: 145 YVHRDLAARNILINSNLV--CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFR 202 Query: 193 EYDGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 ++ +DVWS G+ ++ ++ G P+ + + + + + Y +P + Sbjct: 203 KFTS-ASDVWSYGIVMWEVVSYGERPYWEMTN-----QDVIKAVEEGYRLPSPMDCPAAL 256 Query: 252 CHLISRIFVADPATRISIPEIKT 274 L+ + + +R EI Sbjct: 257 YQLMLDCWQKERNSRPKFDEIVN 279 >4E93-A nrPDB Length = 377 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 96/265 (36%), Gaps = 15/265 (5%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKIDENVQREIINHRS 72 + + + + IG GNFG R + LVAVK + +E + Sbjct: 109 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 168 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSY 131 HPNIVR V + I+ME GG+ + G R +G+ Y Sbjct: 169 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEY 228 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS---TVGTPAYIAPEV 188 S HRDL N L+ LKI DFG S+ S + APE Sbjct: 229 LESKCCIHRDLAARNCLVTEKNV--LKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA 286 Query: 189 LLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L Y + +DVWS G+ L+ +GA P+ + + + + +P Sbjct: 287 LNYGRYSSE-SDVWSFGILLWETFSLGASPYPNLSNQQT-----REFVEKGGRLPCPELC 340 Query: 248 SPECCHLISRIFVADPATRISIPEI 272 L+ + + +P R S I Sbjct: 341 PDAVFRLMEQCWAYEPGQRPSFSTI 365 >4OLI-A nrPDB Length = 645 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 119/284 (41%), Gaps = 26/284 (9%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLM----RDKLTKELVAVKYIER--GDKIDEN 62 P P + ++D+G G+FG L + T E+VAVK ++ G + Sbjct: 342 SPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSG 401 Query: 63 VQREIINHRSLRHPNIVRFKEVILT--PTHLAIIMEYASGGELYERICNAGRFSEDEARF 120 ++EI R+L H +I+++K L ++MEY G L + + + Sbjct: 402 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQLLL 460 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV-- 178 F QQ+ G++Y HS HR+L N LLD +KI DFG +K+ + Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVRED 518 Query: 179 --GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG-----AYP--FEDPEEPRDYRK 229 + APE L ++ +DVWS GVTLY +L + P F + + Sbjct: 519 GDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQM 577 Query: 230 TIQR---ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 T+ R +L +P + E HL+ + + + R + Sbjct: 578 TVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFE 621 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 47/271 (17%), Positives = 84/271 (30%), Gaps = 21/271 (7%) Query: 39 MRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEY 97 RD+ + V +K ++ I + H ++ V + ++ EY Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 147 Query: 98 ASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTL-----LDG 151 G L + G QQL S +SY + + H ++ N L L Sbjct: 148 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 207 Query: 152 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD-GKIADVWSCGVTLYV 210 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 208 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 264 Query: 211 MLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 + G P + ++ + S P L S+ +P R S Sbjct: 265 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-------LTSQCLTYEPTQRPSF 317 Query: 270 PEIKTHSWFLKNLPADLMNESNTGSQFQEPE 300 I + P +L + + Sbjct: 318 RTILRD--LTRLQPHNLADVLTVNPDSPASD 346 >3ALO-A nrPDB Length = 327 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 119/277 (42%), Gaps = 15/277 (5%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKIDENVQREI-INHR 71 ++ + +IG G +G M K + +++AVK I +K + + ++ + R Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASG--GELYERICN--AGRFSEDEARFFFQQLLS 127 S P IV+F + I ME S + Y+ + + E+ + Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 136 Query: 128 GVSYC-HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 +++ +++I HRD+K N LLD S +K+CDFG S V G Y+AP Sbjct: 137 ALNHLKENLKIIHRDIKPSNILLDRS--GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAP 194 Query: 187 EVL----LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 E + RQ YD + +DVWS G+TLY + G +P+ D + + + S Sbjct: 195 ERIDPSASRQGYDVR-SDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNS 253 Query: 243 DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 ++ SP + ++ D + R E+ H + L Sbjct: 254 EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 290 >5O0Y-A nrPDB Length = 579 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 72/283 (25%), Positives = 113/283 (39%), Gaps = 23/283 (8%) Query: 33 FGVARLMRDKLTKELVAVKYI--------ERGDKIDENVQREIINHRSLRHPNIVRFKEV 84 F D + VAVK E+ + ++ RE H+ L HP IV+ + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 85 I-LTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ--ICHRD 141 L ++EY G +L + SE EAR Q+++ + Y + ++ I H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 142 LKLENTLL-DGSPAPRLKICDFGYSKSSVLHSQPKST--------VGTPAYIAPEVLLRQ 192 LK N LL +G+ +KI DFG SK S GT Y+ PE + Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 193 EYDGKIA---DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + KI+ DVWS GV Y L G PF + +D + + + + P ++P Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNT 292 E I R RI + ++ + L ++ + S Sbjct: 537 EAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPA 579 >3A4O-X nrPDB Length = 286 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 103/260 (39%), Gaps = 14/260 (5%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + VK +G+G FG + + VAVK ++ G + E ++L+ Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMSVQAFLEEANLMKTLQ 66 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYC 132 H +VR V+ + II EY + G L + + + G+ + F Q+ G++Y Sbjct: 67 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 126 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 190 HRDL+ N L+ S KI DFG ++ ++ + + APE + Sbjct: 127 ERKNYIHRDLRAANVLVSES--LMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 184 Query: 191 RQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + K +DVWS G+ LY ++ G P+ + LS Y +P Sbjct: 185 FGCFTIK-SDVWSFGILLYEIVTYGKIPYPGRTNAD-----VMTALSQGYRMPRVENCPD 238 Query: 250 ECCHLISRIFVADPATRISI 269 E ++ + R + Sbjct: 239 ELYDIMKMCWKEKAEERPTF 258 >1AD5-A nrPDB Length = 438 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 113/279 (40%), Gaps = 28/279 (10%) Query: 5 PVTTGPLDMPIMHDS-----DRYDFVKDIGSGNFGVARLM-RDKLTKELVAVKYIERGDK 58 P + P D+ + K +G+G FG + +K TK VAVK ++ G Sbjct: 162 PCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSM 219 Query: 59 IDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSED 116 E E ++L+H +V+ V+ T + II E+ + G L + + + + Sbjct: 220 SVEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 278 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 + F Q+ G+++ HRDL+ N L+ S KI DFG ++ Sbjct: 279 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLV--CKIADFGLARVGAKF----- 331 Query: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRIL 235 + APE + + K +DVWS G+ L ++ G P+ P + R L Sbjct: 332 ---PIKWTAPEAINFGSFTIK-SDVWSFGILLMEIVTYGRIPYPGMSNPE-----VIRAL 382 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 Y +P E +++ R + P R + I++ Sbjct: 383 ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 421 >3FME-A nrPDB Length = 290 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIIN-HRSLRH 75 +D + + ++G G +GV MR + +++AVK I + + + ++ R++ Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 65 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYER----ICNAGRFSEDEARFFFQQLLSGVSY 131 P V F + + I ME L + I ED ++ + + Sbjct: 66 PFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 132 CHSM-QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 189 HS + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 125 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L Q+ +D+WS G+T+ + + +P++ P K + + +P D + Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV--VEEPSPQLPAD-KF 239 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFL 279 S E S+ + R + PE+ H +F Sbjct: 240 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >3DLS-A nrPDB Length = 335 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 123/272 (45%), Gaps = 24/272 (8%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE---------NVQREIIN 69 S +Y + +GSG FG DK + V VK+I++ +++ V EI Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 70 HRSLRHPNIVRFKEVILTPTHLAIIME-YASGGELYERICNAGRFSEDEARFFFQQLLSG 128 + H NI++ ++ ++ME + SG +L+ I R E A + F+QL+S Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 V Y I HRD+K EN ++ +K+ DFG + + GT Y APEV Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFT--IKLIDFGSAAYLERGKLFYTFCGTIEYCAPEV 200 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 L+ Y G ++WS GVTLY ++ PF + EE +V+ +I +S Sbjct: 201 LMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEE------------TVEAAIHPPYLVS 248 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLK 280 E L+S + P R ++ ++ T W + Sbjct: 249 KELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >4KIK-B nrPDB Length = 677 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 135/329 (41%), Gaps = 22/329 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER--GDKIDENVQREIINHRSLRHPNIV 79 ++ + +G+G FG ++ T E +A+K + + E EI R L HPN+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 80 RFKEVILTPTHLA------IIMEYASGGELYERIC---NAGRFSEDEARFFFQQLLSGVS 130 ++V +LA + MEY GG+L + + N E + S + Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Y H +I HRDLK EN +L + KI D GY+K S S VGT Y+APE+L Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +Q+Y D WS G + + G PF +P + +++ V + +D+ + Sbjct: 201 EQQKYTV-TVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQ-EPEQPMQSLDT 308 + S P S+ + W L + + G+ P ++LD Sbjct: 260 KF----SSSLPY-PNNLNSVLAERLEKWLQLML---MWHPRQRGTDPTYGPNGCFKALDD 311 Query: 309 IMQIISEATIPAVRNRCLDDFMTDNLDLD 337 I+ + + V +T++ L Sbjct: 312 ILNLKLVHILNMVTGTIHTYPVTEDESLQ 340 >2VWV-A nrPDB Length = 302 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 104/263 (39%), Gaps = 21/263 (7%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIE--RGDKIDENVQREIINHRSLRHPN 77 + IG+G FG R K + VA+K ++ ++ E HPN Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPN 78 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + V+ + I+ E+ G L + N G+F+ + + + SG+ Y M Sbjct: 79 IIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMS 138 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP------AYIAPEVLL 190 HRDL N L++ + K+ DFG S+ +S + + + APE + Sbjct: 139 YVHRDLAARNILVNSNLV--CKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA 196 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++ +D WS G+ ++ M G P+ D + + + Y +P Sbjct: 197 FRKFTS-ASDAWSYGIVMWEVMSFGERPYWDMSN-----QDVINAIEQDYRLPPPPDCPT 250 Query: 250 ECCHLISRIFVADPATRISIPEI 272 L+ + D R P++ Sbjct: 251 SLHQLMLDCWQKDRNARPRFPQV 273 >2PL0-A nrPDB Length = 289 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 109/274 (39%), Gaps = 22/274 (8%) Query: 12 DMPIMHDS-----DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQRE 66 P D + V+ +G+G FG + VAVK +++G + E Sbjct: 10 QKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSPDAFLAE 68 Query: 67 IINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFFQQ 124 + L+H +VR V+ + II EY G L + + + + + ++ Q Sbjct: 69 ANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 181 + G+++ HRDL+ N L+ + + KI DFG ++ + ++ + G Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLS--CKIADFGLAR-LIEDNEYTAREGAKFPI 184 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYS 240 + APE + + K +DVWS G+ L ++ G P+ P + + L Y Sbjct: 185 KWTAPEAINYGTFTIK-SDVWSFGILLTEIVTHGRIPYPGMTNPE-----VIQNLERGYR 238 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + E L+ + P R + +++ Sbjct: 239 MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRS 272 >1K9A-A nrPDB Length = 450 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 102/264 (38%), Gaps = 17/264 (6%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + ++ IG G FG L + VAVK I + D + E LR Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-KNDATAQAFLAEASVMTQLR 244 Query: 75 HPNIVRFKEVI-LTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 H N+V+ VI L I+ EY + G L + + + GR D F + + Y Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 HRDL N L+ K+ DFG +K + + APE L Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE 360 Query: 192 QEYDGKIADVWSCGVTLYVM-LVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 +++ K +DVWS G+ L+ + G P+ PR K + + Y + P Sbjct: 361 KKFSTK-SDVWSFGILLWEIYSFGRVPY-----PRIPLKDVVPRVEKGYKMDAPDGCPPA 414 Query: 251 CCHLISRIFVADPATRISIPEIKT 274 ++ + D ATR + +++ Sbjct: 415 VYDVMKNCWHLDAATRPTFLQLRE 438 >2WTK-C nrPDB Length = 305 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 84/277 (30%), Positives = 132/277 (47%), Gaps = 22/277 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI-----DENVQREIINHRSLRH 75 +Y +G G++G + + D T AVK +++ + NV++EI R LRH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 76 PNIVRFKEVI--LTPTHLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLLSGVSY 131 N+++ +V+ + ++MEY G E+ + + RF +A +F QL+ G+ Y Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGLEY 124 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTPAYIAPEV 188 HS I H+D+K N LL LKI G +++ +++ G+PA+ PE+ Sbjct: 125 LHSQGIVHKDIKPGNLLLTT--GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 189 LLR-QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 + G D+WS GVTLY + G YPFE K + I Y+IP D Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSYAIPGD--C 236 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPA 284 P L+ + +PA R SI +I+ HSWF K P Sbjct: 237 GPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPP 273 >6E4F-A nrPDB Length = 290 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 112/274 (40%), Gaps = 17/274 (6%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-VAVKYIERGDKIDENVQR 65 T G D F+K++G+G FGV + K + VA+K I+ G ++ Sbjct: 18 TAGLGYGSWEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSEDEFIE 75 Query: 66 EIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQ 124 E +L H +V+ V + II EY + G L + RF + + Sbjct: 76 EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 135 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP--- 181 + + Y S Q HRDL N L++ +K+ DFG S+ VL + S+VG+ Sbjct: 136 VCEAMEYLESKQFLHRDLAARNCLVNDQGV--VKVSDFGLSR-YVLDDEYTSSVGSKFPV 192 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYS 240 + PEVL+ ++ K +D+W+ GV ++ + G P+E Q + + Sbjct: 193 RWSPPEVLMYSKFSSK-SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPH 251 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + S + ++ + R + + + Sbjct: 252 L-----ASEKVYTIMYSCWHEKADERPTFKILLS 280 >3E3P-A nrPDB Length = 360 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 126/337 (37%), Gaps = 47/337 (13%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 DR+ + G G FG +L ++K T VA+K + + + + + + L HPNIV Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 80 RFKEVILT-------PTHLAIIMEYAS---GGELYERICNAGRFSEDEARFFFQQLLSGV 129 + + T +L ++MEY + F QL+ + Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSI 142 Query: 130 SYCH--SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 H S+ +CHRD+K N L++ + LK+CDFG +K + + + Y APE Sbjct: 143 GCLHLPSVNVCHRDIKPHNVLVNEAD-GTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPE 201 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS------- 240 ++ ++ D+WS G M++G F + ++ + Sbjct: 202 LIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNP 261 Query: 241 ------------IPDDIRIS-------PECCHLISRIFVADPATRISIPEIKTHSWF--L 279 IP S E L+S + P R+ E H +F L Sbjct: 262 SHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFDEL 321 Query: 280 KNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEA 316 + L N + PE + L ++++SEA Sbjct: 322 HDPATKLPNNKDL------PEDLFRFLPNEIEVMSEA 352 >3V5Q-A nrPDB Length = 297 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 110/275 (40%), Gaps = 34/275 (12%) Query: 24 FVKDIGSGNFGVARLMRD-----KLTKELVAVKYIERGDKI-DENVQREIINHRSLRHPN 77 +++G G FG L K LVAVK ++ ++ QRE +L+H + Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 78 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----------------FSEDEARFF 121 IV+F V L ++ EY G+L + + G + Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTV 178 Q+ SG+ Y S HRDL N L+ + +KI DFG S+ S+ + T+ Sbjct: 139 ASQIASGMVYLASQHFVHRDLATRNCLVGANLL--VKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSV 237 ++ PE ++ +++ + +DVWS GV L+ + G P+ Q + Sbjct: 197 LPIRWMPPESIMYRKFTTE-SDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLE 255 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + + E ++ + +P R++I EI Sbjct: 256 RPRV-----CPKEVYDVMLGCWQREPQQRLNIKEI 285 >5KKR-C nrPDB Length = 395 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 126/303 (41%), Gaps = 45/303 (14%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D ++ + ++G+GN GV + K + ++A K I E I + RE+ P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 127 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HSMQ 136 IV F + ++I ME+ GG L + + AGR E ++ G++Y + Sbjct: 128 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 187 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I HRD+K N L++ +K+CDFG S + S S VGT +Y++PE L Y Sbjct: 188 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTHYSV 244 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPE---------------------------------- 222 + +D+WS G++L M VG YP P+ Sbjct: 245 Q-SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 303 Query: 223 ----EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 P + + I++ S E +++ + +PA R + ++ H++ Sbjct: 304 MDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 363 Query: 279 LKN 281 ++ Sbjct: 364 KRS 366 >3SXS-A nrPDB Length = 268 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 67/260 (25%), Positives = 115/260 (44%), Gaps = 15/260 (5%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV 79 + +K++GSG FGV +L + K + VAVK I+ G ++ +E L HP +V Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLV 66 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQIC 138 +F V + I+ EY S G L + + G+ + + G+++ S Q Sbjct: 67 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 126 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYD 195 HRDL N L+D +K+ DFG ++ VL Q S+VGT + APEV +Y Sbjct: 127 HRDLAARNCLVDRDLC--VKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 183 Query: 196 GKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 K +DVW+ G+ ++ + G P++ K Q + + S + Sbjct: 184 SK-SDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHL-----ASDTIYQI 237 Query: 255 ISRIFVADPATRISIPEIKT 274 + + P R + ++ + Sbjct: 238 MYSCWHELPEKRPTFQQLLS 257 >4AT3-A nrPDB Length = 299 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 117/283 (41%), Gaps = 34/283 (12%) Query: 9 GPLDMPIMH-DSDRYDFVKDIGSGNFGVARLMRD-----KLTKELVAVKYIE-RGDKIDE 61 G +D + H +++G G FG L + K LVAVK ++ D + Sbjct: 1 GAMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK 60 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--------- 112 + RE +L+H +IV+F V + L ++ EY G+L + + G Sbjct: 61 DFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN 120 Query: 113 ----FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-- 166 ++ + QQ+ +G+ Y S HRDL N L+ + +KI DFG S+ Sbjct: 121 PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL--VKIGDFGMSRDV 178 Query: 167 -SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEP 224 S+ + T+ ++ PE ++ +++ + +DVWS GV L+ + G P+ Sbjct: 179 YSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE-SDVWSLGVVLWEIFTYGKQPWYQLSNN 237 Query: 225 RDYRKTIQ-RILSVKYSIPDDIRISPECCHLISRIFVADPATR 266 Q R+L + P E L+ + +P R Sbjct: 238 EVIECITQGRVLQRPRTCPQ------EVYELMLGCWQREPHMR 274 >4XCU-A nrPDB Length = 300 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 111/286 (38%), Gaps = 29/286 (10%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRD-------KLTKELVAVKYIE--RGDKID 60 PLD DR K +G G FG VAVK ++ DK Sbjct: 7 PLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL 66 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-------NAGR 112 ++ E+ + + RH NI+ V L +I+E A+ G L E + + G Sbjct: 67 ADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGP 126 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLH 171 S Q+ G+ Y S + HRDL N L+ +KI DFG ++ + Sbjct: 127 LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNV--MKIADFGLARGVHHID 184 Query: 172 SQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYR 228 K++ G ++APE L + Y + +DVWS G+ L+ + G P+ + Sbjct: 185 YYKKTSNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGILLWEIFTLGGSPYPGIPVEELFS 243 Query: 229 KTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 +L + + PE L+ + A P+ R + ++ Sbjct: 244 -----LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >5TQX-A nrPDB Length = 655 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 82/349 (23%), Positives = 134/349 (38%), Gaps = 48/349 (13%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVK--YIERGDKIDENVQREIINHRSLRHPNIV 79 ++ + +G+G FG L + + +A+K +E K E EI + L H N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 80 RFKEVILTPTHLAII--------MEYASGGELYERICNAGR---FSEDEARFFFQQLLSG 128 + P L I+ MEY SGG+L + + E + + SG Sbjct: 70 K---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 126 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 + Y H +I HRDLK EN +L + KI D GY+K VGT Y+APE Sbjct: 127 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE 186 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI----------LSV 237 + + Y D WS G ++ + G PF +P + + I++ +S Sbjct: 187 LFENKPYTA-TVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSG 245 Query: 238 KYSIPDDIRISPECCHLI--------SRIFVADPATR-----ISIPE-----IKTHSWFL 279 + + C LI + DP R +++ + + H L Sbjct: 246 EVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNL 305 Query: 280 KNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDD 328 K + M + S P++ + SL + +I E I L + Sbjct: 306 KIVHILNMTSAKIISFLLPPDESLHSLQS--RIERETGINTGSQELLSE 352 >5O2B-A nrPDB Length = 285 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 122/272 (44%), Gaps = 20/272 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHPN 77 ++D ++G G F D T VA + + + + E + L+HPN Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 76 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 IVRF + + + ++ E + G L + R + +Q+L G+ + H Sbjct: 77 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLH 136 Query: 134 SMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 + I HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + Sbjct: 137 TRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE--MY 192 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE-PRDYRKTIQRILSVKYSIPDDIRISPE 250 +E+ + DV++ G+ + M YP+ + + + YRK I ++ PE Sbjct: 193 EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN----KVTDPE 248 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 +I + + R+SI ++ H++F ++ Sbjct: 249 VKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >1BYG-A nrPDB Length = 278 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 101/264 (38%), Gaps = 17/264 (6%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + ++ IG G FG L + VAVK I + D + E LR Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-KNDATAQAFLAEASVMTQLR 72 Query: 75 HPNIVRFKEVI-LTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 H N+V+ VI L I+ EY + G L + + + GR D F + + Y Sbjct: 73 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 132 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 HRDL N L+ K+ DFG +K + + APE L Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE 188 Query: 192 QEYDGKIADVWSCGVTLYVM-LVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 +++ K +DVWS G+ L+ + G P+ PR K + + Y + P Sbjct: 189 KKFSTK-SDVWSFGILLWEIYSFGRVPY-----PRIPLKDVVPRVEKGYKMDAPDGCPPA 242 Query: 251 CCHLISRIFVADPATRISIPEIKT 274 ++ + D A R S +++ Sbjct: 243 VYEVMKNCWHLDAAMRPSFLQLRE 266 >3N9X-A nrPDB Length = 432 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 83/386 (21%), Positives = 132/386 (34%), Gaps = 87/386 (22%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRS 72 +H D Y IG G++G L DK T++ VA+K + R + + + REI Sbjct: 22 VHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNR 81 Query: 73 LRHPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLS 127 L+ I+R ++I+ L I++E A +L + +E+ + LL Sbjct: 82 LKSDYIIRLYDLIIPDDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEEHIKTILYNLLL 140 Query: 128 GVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS------------------- 168 G ++ H I HRDLK N LL+ + +K+CDFG +++ Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCS--VKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 169 ----VLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML-----------V 213 L Q S V T Y APE++L QE K D+WS G +L Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTN 258 Query: 214 GAYPFEDP----------------EEPRDYRKTIQRILSVKYS----------------- 240 F + RD I I+ Sbjct: 259 RFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKL 318 Query: 241 IP---------DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESN 291 P IS + +L+ + +P RI+I + H + L N S Sbjct: 319 FPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLENFST 378 Query: 292 TGSQFQEPEQPMQSLDTIMQIISEAT 317 + + S + I + Sbjct: 379 KKIILPFDDWMVLSETQLRYIFLKEV 404 >4E20-A nrPDB Length = 290 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 117/279 (41%), Gaps = 26/279 (9%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLM----RDKLTKELVAVKYIERG--DKIDENVQREI 67 P + ++D+G G+FG L + T E+VAVK ++ G ++ QREI Sbjct: 2 PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREI 61 Query: 68 INHRSLRHPNIVRFKEVILT--PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL 125 R+L H +IV++K + ++MEY G L + + + F QQ+ Sbjct: 62 EILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQI 120 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTP 181 G++Y H+ HR L N LLD +KI DFG +K+ + Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRL--VKIGDFGLAKAVPEGHEYYRVREDGDSPV 178 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV----GAYP---FEDPEEPRDYRKTIQR- 233 + APE L ++ +DVWS GVTLY +L P F + + T+ R Sbjct: 179 FWYAPECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRL 237 Query: 234 --ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 +L +P R E HL+ + + + R + Sbjct: 238 TELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQ 276 >3EQC-A nrPDB Length = 360 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 126/303 (41%), Gaps = 45/303 (14%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D ++ + ++G+GN GV + K + ++A K I E I + RE+ P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 92 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HSMQ 136 IV F + ++I ME+ GG L + + AGR E ++ G++Y + Sbjct: 93 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 152 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I HRD+K N L++ +K+CDFG S + S S VGT +Y++PE L Y Sbjct: 153 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMSPERLQGTHYSV 209 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPE---------------------------------- 222 + +D+WS G++L M VG YP P+ Sbjct: 210 Q-SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFG 268 Query: 223 ----EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 P + + I++ S E +++ + +PA R + ++ H++ Sbjct: 269 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 328 Query: 279 LKN 281 ++ Sbjct: 329 KRS 331 >3TT0-A nrPDB Length = 382 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D DR K +G G FG L +DK + VAVK ++ +K Sbjct: 59 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 118 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +I+EYAS G L E + Sbjct: 119 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSY 178 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 S + Q+ G+ Y S + HRDL N L+ +KI DFG Sbjct: 179 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFG 236 Query: 164 YSKS-SVLHSQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ + K+T G ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYP 295 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + E ++ + A P+ R + ++ Sbjct: 296 GVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >4PWN-A nrPDB Length = 274 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 118/275 (42%), Gaps = 16/275 (5%) Query: 16 MHDSDRY-DFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHR 71 M + R+ F +IG G+F D T VA + + + + E + Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLK 64 Query: 72 SLRHPNIVRFKEVILT----PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLS 127 L+HPNIVRF + + + ++ E + G L + R + +Q+L Sbjct: 65 GLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILK 124 Query: 128 GVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 G+ + H+ I HRDLK +N + G P +KI D G + S KS +GTP ++A Sbjct: 125 GLQFLHTRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLATLEKRASFAKSVIGTPEFMA 183 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE + +E + DV++ G+ + M YP+ + + + +R+ S D Sbjct: 184 PE--MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAA---QIYRRVTSGVKPASFDK 238 Query: 246 RISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 PE +I + R SI ++ H++F + Sbjct: 239 VAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3PG1-A nrPDB Length = 362 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 122/339 (35%), Gaps = 49/339 (14%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKY------------IERGDKIDENVQREIIN 69 Y + I SG++G D VA+K I + + V REI Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 70 HRSLRHPNIVRFKEVILTPTH-----LAIIMEYASGGELYERICNAG-RFSEDEARFFFQ 123 HPNI+ +++ + L ++ E +L + I + S ++F Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQYFMY 141 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 +L G+ H + HRDL N LL + + ICDF ++ + V Y Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADN--NDITICDFNLAREDTADANKTHYVTHRWY 199 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK----- 238 APE++++ + K+ D+WS G + M F K ++ + + K Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 239 -YSIP---DDIRIS-----------------PECCHLISRIFVADPATRISIPEIKTHSW 277 +S P D +R S P LI+++ +P RIS + H + Sbjct: 260 MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPY 319 Query: 278 FLKNL-PADLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 F P DL + F E + + I E Sbjct: 320 FESLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVE 358 >6O6Q-A nrPDB Length = 335 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 40/297 (13%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-R 74 + + Y+ ++ +G G + L D +E V +K ++ + ++REI ++L Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK--PVKRKKIKREISILKNLVD 94 Query: 75 HPNIVRFKEVILTPTHLA--IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 PNI+ +V+ P +I E+ + + F++ + RF+ +LL + Y Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYELLKALDYS 151 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HSM I HRD+K N ++D L++ D+G ++ ++ V + + PE+L+ Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKL-LRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK-------------- 238 D+WS G L M+ PF + D I R+L K Sbjct: 211 RLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLG 270 Query: 239 --------YSIPDDIR---------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 Y+ +R +S E LI R+ D R++ E H++F Sbjct: 271 EEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >5O2C-A nrPDB Length = 380 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 122/272 (44%), Gaps = 20/272 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHRSLRHPN 77 ++D ++G G F D T VA + + + + E + L+HPN Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 85 Query: 78 IVRFKEVILT----PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 IVRF + + + ++ E + G L + R + +Q+L G+ + H Sbjct: 86 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLH 145 Query: 134 SMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 + I HRDLK +N + G P +KI D G + + + S KS +GTP ++APE + Sbjct: 146 TRTPPIIHRDLKCDNIFITG-PTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPE--MY 201 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE-PRDYRKTIQRILSVKYSIPDDIRISPE 250 +E+ + DV++ G+ + M YP+ + + + YRK I ++ PE Sbjct: 202 EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFN----KVTDPE 257 Query: 251 CCHLISRIFVADPATRISIPEIKTHSWFLKNL 282 +I + + R+SI ++ H++F ++ Sbjct: 258 VKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >3ORP-A nrPDB Length = 311 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 112/275 (40%), Gaps = 24/275 (8%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE----RGDKIDENVQREIINHRS 72 H SDRY+ + +G G L RD VAVK + R +RE N + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 73 LRHPNIVRFKEVILTPTHL----AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 L HP IV + T I+MEY G L + + G + A Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS----QPKSTVGTPAYI 184 +++ H I HRD+K N ++ + A +K+ DFG +++ Q + +GT Y+ Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNA--VKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD 244 +PE D + +DV+S G LY +L G PF + ++ + IP Sbjct: 187 SPEQARGDSVDAR-SDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR-----EDPIPPS 240 Query: 245 IR---ISPECCHLISRIFVADPATRI-SIPEIKTH 275 R +S + ++ + +P R + E++ Sbjct: 241 ARHEGLSADLDAVVLKALAKNPENRYQTAAEMRAD 275 >6FEX-A nrPDB Length = 321 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 110/315 (34%), Gaps = 43/315 (13%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR--------------DKLTKE--LV 48 P G + R F + +G G FG L + LV Sbjct: 1 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 60 Query: 49 AVKYIERG--DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYER 106 AVK + + +E+ L+ PNI+R V + L +I +Y G+L + Sbjct: 61 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 107 ICNAG-------------RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSP 153 + S Q+ SG+ Y ++ HRDL N L+ + Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF 180 Query: 154 APRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYV 210 +KI DFG S++ + V ++A E +L ++ +DVW+ GVTL+ Sbjct: 181 T--IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT-ASDVWAFGVTLWE 237 Query: 211 --MLVGAYPFEDPEEPRDYRK--TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATR 266 ML A PF + + R + + L+ R + + R Sbjct: 238 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 Query: 267 ISIPEIKTHSWFLKN 281 ++ H + ++ Sbjct: 298 PPFSQL--HRFLAED 310 >3KUL-B nrPDB Length = 325 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 110/266 (41%), Gaps = 19/266 (7%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKEL---VAVKYIERG--DKIDENVQREIINHRS 72 ++ R K IGSG+ G R ++ + VA+K ++ G ++ + E Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQ 106 Query: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSY 131 HPNI+R + V+ I+ EY G L + + G+F+ + + + +G+ Y Sbjct: 107 FDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRY 166 Query: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVG--TPAYIAPE 187 + HRDL N L+D + K+ DFG S+ + +T G + APE Sbjct: 167 LSDLGYVHRDLAARNVLVDSNLV--CKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPE 224 Query: 188 VLLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 + + + +DVWS GV ++ + G P+ + + + + Y +P + Sbjct: 225 AIAFRTFSS-ASDVWSFGVVMWEVLAYGERPYWNMTN-----RDVISSVEEGYRLPAPMG 278 Query: 247 ISPECCHLISRIFVADPATRISIPEI 272 L+ + D A R +I Sbjct: 279 CPHALHQLMLDCWHKDRAQRPRFSQI 304 >3RP9-A nrPDB Length = 458 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 85/388 (21%), Positives = 133/388 (34%), Gaps = 95/388 (24%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---E 61 P + P DRY+ IG+G++G DKL K +VA+K I R + + Sbjct: 38 PTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCK 97 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSED 116 + REI L H ++V+ ++++ L +++E A + + +E Sbjct: 98 RILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADS-DFKKLFRTPVYLTEL 156 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV------- 169 + LL GV Y HS I HRDLK N L++ + +K+CDFG +++ Sbjct: 157 HIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCS--VKVCDFGLARTVDYPENGNS 214 Query: 170 ---------------------LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTL 208 L Q V T Y APE++L QE + DVWS G Sbjct: 215 QLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIF 274 Query: 209 YVMLV-----------GAYPFEDPEE-------------------PRDYRKTIQRILSVK 238 +L F RD I IL Sbjct: 275 AELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTP 334 Query: 239 YS-----------------IPD---------DIRISPECCHLISRIFVADPATRISIPEI 272 P S + HL+ R+ V +P RI+I E Sbjct: 335 SEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINEC 394 Query: 273 KTHSWFLKNLPADLMNESNTGSQFQEPE 300 H +F + A++ + + + Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFND 422 >5KMM-A nrPDB Length = 329 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 106/273 (38%), Gaps = 37/273 (13%) Query: 27 DIGSGNFGVARLMRDK-----LTKELVAVKYIER-GDKIDENVQREIINHRSLRHPNIVR 80 ++G G FG L K LVAVK ++ + ++ QRE L+H +IVR Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVR 101 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNA---------------GRFSEDEARFFFQQL 125 F V L ++ EY G+L + + G + Q+ Sbjct: 102 FFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQV 161 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---- 181 +G+ Y + HRDL N L+ +KI DFG S+ ++S VG Sbjct: 162 AAGMVYLAGLHFVHRDLATRNCLVG--QGLVVKIGDFGMSR--DIYSTDYYRVGGRTMLP 217 Query: 182 -AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKY 239 ++ PE +L +++ + +DVWS GV L+ + G P+ Q Sbjct: 218 IRWMPPESILYRKFTTE-SDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ-----GR 271 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + PE ++ + +P R SI ++ Sbjct: 272 ELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 304 >4HZS-A nrPDB Length = 341 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 131/319 (41%), Gaps = 27/319 (8%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR-DKLTKELV--AVKYIE----RGDKIDE 61 G + + ++ +G G+FGV R D + + V AVK ++ + + Sbjct: 1 GSQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD 60 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARF 120 + RE+ SL H N++R V+LTP + ++ E A G L +R+ G F Sbjct: 61 DFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSR 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK----S 176 + Q+ G+ Y S + HRDL N LL +KI DFG ++ + Sbjct: 120 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL--VKIGDFGLMRALPQNDDHYVMQEH 177 Query: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRIL 235 A+ APE L + + +D W GVTL+ M G P+ + + +I Sbjct: 178 RKVPFAWCAPESLKTRTFSH-ASDTWMFGVTLWEMFTYGQEPWIGLNGSQ----ILHKID 232 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQ 295 +P + +++ + + P R + ++ + L+ P D+ Sbjct: 233 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDM----RALQD 286 Query: 296 FQEPEQPMQSLDTIMQIIS 314 F+EP++ ++ ++ +I Sbjct: 287 FEEPDKLHIQMNDVITVIE 305 >5A46-A nrPDB Length = 386 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D DR K +G G FG L +DK + VAVK ++ +K Sbjct: 30 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 89 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +I+EYAS G L E + Sbjct: 90 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 149 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 S + Q+ G+ Y S + HRDL N L+ +KI DFG Sbjct: 150 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFG 207 Query: 164 YSKS-SVLHSQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ + K+T G ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 208 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYP 266 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + E ++ + A P+ R + ++ Sbjct: 267 GVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >3EB0-A nrPDB Length = 383 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 70/324 (21%), Positives = 120/324 (37%), Gaps = 68/324 (20%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 S +Y K +G+G+FG+ + D + + A+K + + + RE+ + L H NI Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK---NRELDIMKVLDHVNI 62 Query: 79 VRFKEVILT--------------------------------------PTHLAIIMEYAS- 99 ++ + T +L +IMEY Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 100 --GGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRL 157 L I + + + QL V + HS+ ICHRD+K +N L++ L Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT-L 181 Query: 158 KICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYP 217 K+CDFG +K + + + + Y APE++L D+WS G +++G Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPL 241 Query: 218 FEDPEEPRDYRKTIQRILS-------------VKYSIP-----DDIRISPE-----CCHL 254 F + IQ + + + P D +I PE L Sbjct: 242 FSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDL 301 Query: 255 ISRIFVADPATRISIPEIKTHSWF 278 + +I +P RI+ E H +F Sbjct: 302 LEQILRYEPDLRINPYEAMAHPFF 325 >6BSD-A nrPDB Length = 876 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 110/321 (34%), Gaps = 49/321 (15%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR--------------DKLTKE--LV 48 P G + R F + +G G FG L + LV Sbjct: 556 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 615 Query: 49 AVKYIERG--DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYER 106 AVK + + +E+ L+ PNI+R V + L +I +Y G+L + Sbjct: 616 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 675 Query: 107 ICNAG-------------------RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 + S Q+ SG+ Y ++ HRDL N Sbjct: 676 LSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNC 735 Query: 148 LLDGSPAPRLKICDFGYSKSSVLHSQPK---STVGTPAYIAPEVLLRQEYDGKIADVWSC 204 L+ + +KI DFG S++ + V ++A E +L ++ +DVW+ Sbjct: 736 LVGENFT--IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT-ASDVWAF 792 Query: 205 GVTLYV--MLVGAYPFEDPEEPRDYRK--TIQRILSVKYSIPDDIRISPECCHLISRIFV 260 GVTL+ ML A PF + + R + + L+ R + Sbjct: 793 GVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS 852 Query: 261 ADPATRISIPEIKTHSWFLKN 281 + R ++ H + ++ Sbjct: 853 RESEQRPPFSQL--HRFLAED 871 >4PDO-A nrPDB Length = 299 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 59/259 (22%), Positives = 107/259 (41%), Gaps = 20/259 (7%) Query: 26 KDIGSGNFGVARLMRDK-LTKEL---VAVKYIERG--DKIDENVQREIINHRSLRHPNIV 79 K IG+G FG K + + VA+K ++ G +K + E H NI+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 80 RFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYCHSMQIC 138 R + VI + II EY G L + + G FS + + + +G+ Y +M Sbjct: 100 RLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYV 159 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLRQEY 194 HRDL N L++ + K+ DFG S+ + T + APE + +++ Sbjct: 160 HRDLAARNILVNSNLV--CKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF 217 Query: 195 DGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 +DVWS G+ ++ M G P+ + + + ++ + +P + Sbjct: 218 TS-ASDVWSFGIVMWEVMTYGERPYWELSNHE-----VMKAINDGFRLPTPMDCPSAIYQ 271 Query: 254 LISRIFVADPATRISIPEI 272 L+ + + + A R +I Sbjct: 272 LMMQCWQQERARRPKFADI 290 >3GQL-A nrPDB Length = 326 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D DR K +G G FG L +DK + VAVK ++ +K Sbjct: 18 PEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 77 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +I+EYAS G L E + Sbjct: 78 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 137 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 S + Q+ G+ Y S + HRDL N L+ +KI DFG Sbjct: 138 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV--MKIADFG 195 Query: 164 YSKS-SVLHSQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ + K+T G ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 196 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ-SDVWSFGVLLWEIFTLGGSPYP 254 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + E ++ + A P+ R + ++ Sbjct: 255 GVPVEELF-----KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >4EQM-A nrPDB Length = 294 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 82/264 (31%), Positives = 119/264 (45%), Gaps = 11/264 (4%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI----ERGDKIDENVQREIINHRSLR 74 ++RY V +G G L D + VA+K I ++ + +RE+ N L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 H NIV +V ++MEY G L E I + G S D A F Q+L G+ + H Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHD 129 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS--QPKSTVGTPAYIAPEVLLRQ 192 M+I HRD+K +N L+D + LKI DFG +K+ S Q +GT Y +PE + Sbjct: 130 MRIVHRDIKPQNILIDSNKT--LKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 + D++S G+ LY MLVG PF K IQ + + I Sbjct: 188 A-TDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVP-NVTTDVRKDIPQSLS 245 Query: 253 HLISRIFVADPATRI-SIPEIKTH 275 ++I R D A R +I E+K Sbjct: 246 NVILRATEKDKANRYKTIQEMKDD 269 >6GVJ-A nrPDB Length = 429 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 112/290 (38%), Gaps = 27/290 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSL--RHP 76 Y +K IGSG + + K++ A+KY+ + ++ + + EI L Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 205 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 263 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLRQE 193 I H DLK N L+ LK+ DFG + + S VGT Y+ PE + Sbjct: 264 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 194 YD----------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +DVWS G LY M G PF+ I + + PD Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPD 379 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 + ++ DP RISIPE+ H + + P + M + T Sbjct: 380 IPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 427 >2PSQ-A nrPDB Length = 370 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D D+ K +G G FG + +DK + VAVK ++ +K Sbjct: 71 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 130 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +I+EYAS G L E + Sbjct: 131 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY 190 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 + + QL G+ Y S + HRDL N L+ + +KI DFG Sbjct: 191 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV--MKIADFG 248 Query: 164 YSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ + + + + ++APE L + Y + +DVWS GV ++ + G P+ Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMWEIFTLGGSPYP 307 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + E ++ + A P+ R + ++ Sbjct: 308 GIPVEELF-----KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >3NIE-A nrPDB Length = 429 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 77/370 (20%), Positives = 120/370 (32%), Gaps = 90/370 (24%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID---ENVQREIINHRSLR 74 D Y+ IG G++G L DK + VA+K + R + + + REI L+ Sbjct: 26 VPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLK 85 Query: 75 HPNIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 I+R ++I+ L I++E A +L + +E + LL G Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEQHVKTILYNLLLGE 144 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH------------------ 171 + H I HRDLK N LL+ + +KICDFG +++ Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCS--VKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 172 --------SQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML----------- 212 Q S V T Y APE++L QE D+WS G +L Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPT 262 Query: 213 VGAYPFEDP----------------EEPRDYRKTIQRILSVKYS---------------- 240 F + RD I ++ Sbjct: 263 NRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIK 322 Query: 241 -IP---------DDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 P IS E L+ + + RI+I + +H + +L N S Sbjct: 323 LFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFS 382 Query: 291 NTGSQFQEPE 300 + Sbjct: 383 TEKIILPFDD 392 >5AMN-A nrPDB Length = 299 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 109/285 (38%), Gaps = 29/285 (10%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDE--NVQ 64 D K +G G FG + + VAVK ++ E ++ Sbjct: 15 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 74 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----------FS 114 E + + HP++++ L +I+EYA G L + + + + Sbjct: 75 SEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALT 134 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQ 173 + F Q+ G+ Y M++ HRDL N L+ + ++KI DFG S+ S Sbjct: 135 MGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV--AEGRKMKISDFGLSRDVYEEDSY 192 Query: 174 PKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKT 230 K + G ++A E L Y + +DVWS GV L+ ++ G P+ R + Sbjct: 193 VKRSQGRIPVKWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGNPYPGIPPERLF--- 248 Query: 231 IQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 +L + + S E L+ + + +P R +I Sbjct: 249 --NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 291 >1LUF-A nrPDB Length = 343 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 117/304 (38%), Gaps = 45/304 (14%) Query: 2 DRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDK-----LTKELVAVKYIER- 55 R P+ P + + + + ++V+DIG G FG R +VAVK ++ Sbjct: 29 QRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEE 88 Query: 56 -GDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA---- 110 + + QRE +PNIV+ V + ++ EY + G+L E + + Sbjct: 89 ASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT 148 Query: 111 --------------------GRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLD 150 S E +Q+ +G++Y + HRDL N L+ Sbjct: 149 VCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG 208 Query: 151 GSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVT 207 + +KI DFG S+ S+ + + ++ PE + Y + +DVW+ GV Sbjct: 209 ENMV--VKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTE-SDVWAYGVV 265 Query: 208 LYVML-VGAYPFEDP-EEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPAT 265 L+ + G P+ E Y IL+ + P E +L+ + PA Sbjct: 266 LWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCP------LELYNLMRLCWSKLPAD 319 Query: 266 RISI 269 R S Sbjct: 320 RPSF 323 >1ZXE-A nrPDB Length = 303 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 116/289 (40%), Gaps = 35/289 (12%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 + ++ + +G G FG R+ L A+K I ++ + E++ SL H + Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYV 64 Query: 79 VRFKEVILT-------------PTHLAIIMEYASGGELYERICNAGRFSE-DEARFFFQQ 124 VR+ L + L I MEY LY+ I + + DE F+Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--------------- 169 +L +SY HS I HR+LK N +D S +KI DFG +K+ Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESR--NVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 S +GT Y+A EVL + + D++S G+ + M+ YPF E + K Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILK 239 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 ++ + S+++ D +I + DP R + W Sbjct: 240 KLRSV-SIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >2W1I-A nrPDB Length = 326 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 118/282 (41%), Gaps = 26/282 (9%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMRDK----LTKELVAVKYIERGDKID-ENVQREII 68 P + F++ +G GNFG + R T E+VAVK ++ + + +REI Sbjct: 35 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 94 Query: 69 NHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQL 125 +SL+H NIV++K V + +L +IMEY G L + + R + + Q+ Sbjct: 95 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 154 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST----VGTP 181 G+ Y + + HRDL N L++ R+KI DFG +K + Sbjct: 155 CKGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 212 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-----GAYP------FEDPEEPRDYRKT 230 + APE L ++ +DVWS GV LY + + P + ++ + Sbjct: 213 FWYAPESLTESKFSV-ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFH 271 Query: 231 IQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + +L +P E +++ + + R S ++ Sbjct: 272 LIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >6GQK-A nrPDB Length = 328 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 99/294 (33%), Gaps = 35/294 (11%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDEN-- 62 P D +R F K +G+G FG VAVK ++ E Sbjct: 31 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREA 90 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--------- 112 + E+ L H NIV +I EY G+L + Sbjct: 91 LMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAP 150 Query: 113 -------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYS 165 + + F Q+ G+++ S HRDL N LL KICDFG + Sbjct: 151 EDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT--KICDFGLA 208 Query: 166 KSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDP 221 + S ++APE + Y + +DVWS G+ L+ + G+ P+ Sbjct: 209 RDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFE-SDVWSYGIFLWELFSLGSSPYPGM 267 Query: 222 EEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + K I + + E ++ + ADP R + +I Sbjct: 268 PVDSKFYKMI----KEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >6DBN-A nrPDB Length = 316 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 124/278 (44%), Gaps = 27/278 (9%) Query: 17 HDSDRY-DFVKDIGSGNFGVARLMR----DKLTKELVAVKYIERGDKIDE--NVQREIIN 69 H R+ ++D+G G+FG L R T E VAVK ++ + ++++EI Sbjct: 31 HFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEI 90 Query: 70 HRSLRHPNIVRFKEVILTP--THLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLL 126 R+L H NIV++K + + +IME+ G L E + N + + + + Q+ Sbjct: 91 LRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQIC 150 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP----A 182 G+ Y S Q HRDL N L++ ++KI DFG +K+ + + Sbjct: 151 KGMDYLGSRQYVHRDLAARNVLVESEH--QVKIGDFGLTKAIETDKEYYTVKDDRDSPVF 208 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLV----GAYP---FEDPEEPRDYRKTIQRI- 234 + APE L++ ++ +DVWS GVTL+ +L + P F P + T+ R+ Sbjct: 209 WYAPECLMQSKFYI-ASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV 267 Query: 235 --LSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 L +P E L+ + + P+ R S Sbjct: 268 NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQ 305 >5HVK-A nrPDB Length = 315 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 26/296 (8%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIER-GDKIDENVQREIINHRSLRHPNIVRFKE 83 + +G G FG A + + T E++ +K + R ++ +E+ R L HPN+++F Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 84 VILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 V+ L I EY GG L I + ++ + F + + SG++Y HSM I HR+L Sbjct: 79 VLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRNL 138 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLH---------------SQPKSTVGTPAYIAPE 187 N L+ + + + DFG ++ V + + VG P ++APE Sbjct: 139 NSHNCLVRENK--NVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 ++ + YD K DV+S G+ L ++ G + PR + + P Sbjct: 197 MINGRSYDEK-VDVFSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCPP--NC 252 Query: 248 SPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPM 303 P + R DP R S + H W + L L G Q ++ ++ Sbjct: 253 PPSFFPITVRCCDLDPEKRPSFVK-LEH-WL-ETLRMHLAGHLPLGPQLEQLDRGF 305 >4H1J-A nrPDB Length = 293 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 104/258 (40%), Gaps = 18/258 (6%) Query: 24 FVKDIGSGNFGVARLMR---DKLTKELVAVKYIERG--DKIDENVQREIINHRSLRHPNI 78 + +G G FG K K VAVK ++ E E + ++L HP+I Sbjct: 28 LNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHI 87 Query: 79 VRFKEVILTPTHLAIIMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 V+ +I IIME GEL + N + Q+ ++Y S+ Sbjct: 88 VKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINC 146 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG--TPAYIAPEVLLRQEYD 195 HRD+ + N L+ +K+ DFG S+ K++V +++PE + + + Sbjct: 147 VHRDIAVRNILVASPEC--VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFT 204 Query: 196 GKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 +DVW V ++ +L G PF E K + +L +P P L Sbjct: 205 T-ASDVWMFAVCMWEILSFGKQPFFWLEN-----KDVIGVLEKGDRLPKPDLCPPVLYTL 258 Query: 255 ISRIFVADPATRISIPEI 272 ++R + DP+ R E+ Sbjct: 259 MTRCWDYDPSDRPRFTEL 276 >1S9I-A nrPDB Length = 354 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 127/307 (41%), Gaps = 49/307 (15%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI--ERGDKIDENVQREIINHRSLRHPN 77 D ++ + ++G+GN GV ++ + + ++A K I E I + RE+ P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 75 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC-HSMQ 136 IV F + ++I ME+ GG L + + A R E+ +L G++Y Q Sbjct: 76 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQ 135 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 I HRD+K N L++ +K+CDFG S + S S VGT +Y+APE L Y Sbjct: 136 IMHRDVKPSNILVNS--RGEIKLCDFGVSGQLI-DSMANSFVGTRSYMAPERLQGTHYSV 192 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRD------------------------------ 226 + +D+WS G++L + VG YP P+ Sbjct: 193 Q-SDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 251 Query: 227 ------------YRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + + I++ + +P+ +++ + +PA R + + Sbjct: 252 SGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTN 311 Query: 275 HSWFLKN 281 H++ ++ Sbjct: 312 HTFIKRS 318 >1U54-B nrPDB Length = 291 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 122/295 (41%), Gaps = 24/295 (8%) Query: 9 GPLDMPIMHDSDR-YDFVKDIGSGNFGVARLMR-DKLTKELV--AVKYIE----RGDKID 60 GPL ++ ++ +G G+FGV R D + + V AVK ++ + Sbjct: 6 GPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAM 65 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEAR 119 ++ RE+ SL H N++R V+LTP + ++ E A G L +R+ G F Sbjct: 66 DDFIREVNAMHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLS 124 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---- 175 + Q+ G+ Y S + HRDL N LL +KI DFG ++ + Sbjct: 125 RYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL--VKIGDFGLMRALPQNDDHYVMQE 182 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRI 234 A+ APE L + + +D W GVTL+ M G P+ + + +I Sbjct: 183 HRKVPFAWCAPESLKTRTFSH-ASDTWMFGVTLWEMFTYGQEPWIGLNGSQ----ILHKI 237 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 +P + +++ + + P R + ++ + L+ P D+ E Sbjct: 238 DKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD--FLLEAQPTDMRAE 290 >5X8I-B nrPDB Length = 346 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 114/322 (35%), Gaps = 68/322 (21%) Query: 21 RYDFVKDIGSGNFGVARLMR-DKLTKELVAVKYIERGDKIDENVQREIINHRSLR--HPN 77 RY+ V +G G FG K VAVK ++ D+ E + EI L PN Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 78 ----IVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSY 131 V+ E H+ I+ E G Y+ I G F D R Q+ V++ Sbjct: 74 STFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNF 132 Query: 132 CHSMQICHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHSQP 174 HS ++ H DLK EN L S P +K+ DFG + Sbjct: 133 LHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--DDEHH 190 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY------- 227 + V T Y APEV+L + + DVWS G L +G F + Sbjct: 191 STLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERIL 249 Query: 228 ----RKTIQRILSVKYSIPDDIR----------ISPECC-----------------HLIS 256 + IQ+ KY D + +S C LI Sbjct: 250 GPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQ 309 Query: 257 RIFVADPATRISIPEIKTHSWF 278 ++ DPA RI++ E H +F Sbjct: 310 KMLEYDPAKRITLREALKHPFF 331 >3IO7-A nrPDB Length = 313 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 121/290 (41%), Gaps = 27/290 (9%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDK----LTKELVAVKYIERGDKID- 60 V G +M + F++ +G GNFG + R T E+VAVK ++ + Sbjct: 15 VPRGSHNM-TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL 73 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAG-RFSEDE 117 + +REI +SL+H NIV++K V + +L +IMEY G L + + R + Sbjct: 74 RDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIK 133 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST 177 + Q+ G+ Y + + HRDL N L++ R+KI DFG +K + Sbjct: 134 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE--NRVKIGDFGLTKVLPQDKEYYKV 191 Query: 178 ----VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-----GAYP------FEDPE 222 + APE L ++ +DVWS GV LY + + P + + Sbjct: 192 KEPGESPIFWYAPESLTESKFSV-ASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDK 250 Query: 223 EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + + + +L +P E +++ + + R S ++ Sbjct: 251 QGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3HMP-A nrPDB Length = 342 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 112/290 (38%), Gaps = 27/290 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSL--RHP 76 Y +K IGSG + + K++ A+KY+ + ++ + + EI L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 117 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLRQE 193 I H DLK N L+ LK+ DFG + + S VGT Y+ PE + Sbjct: 176 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 232 Query: 194 YD----------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +DVWS G LY M G PF+ I + + PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPD 291 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 + ++ DP RISIPE+ H + + P + M + T Sbjct: 292 IPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 339 >4K33-A nrPDB Length = 325 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 113/296 (38%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D R K +G G FG + +D+ K VAVK ++ DK Sbjct: 26 PADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL 85 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +++EYA+ G L E + Sbjct: 86 SDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSF 145 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 + + Q+ G+ Y S + HRDL N L+ +KI DFG Sbjct: 146 DTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV--MKIADFG 203 Query: 164 YSK---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ + + + + ++APE L + Y + +DVWS GV L+ + G P+ Sbjct: 204 LARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLLWEIFTLGGSPYP 262 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + + ++ + A P+ R + ++ Sbjct: 263 GIPVEELF-----KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >4IDT-A nrPDB Length = 356 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 73/255 (28%), Positives = 103/255 (40%), Gaps = 23/255 (9%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G+FG M DK T AVK + E E++ L P IV + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----ELMACAGLTSPRIVPLYGAVRE 137 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 + I ME GG L + + G ED A ++ Q L G+ Y HS +I H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNV 197 Query: 148 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLRQEYDGKIADV 201 LL +CDFG++ K + GT ++APEV+L + D K DV Sbjct: 198 LLSSDG-SHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAK-VDV 255 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL----ISR 257 WS + ML G +P+ L + P I P C L I Sbjct: 256 WSSCCMMLHMLNGCHPW-------TQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQE 308 Query: 258 IFVADPATRISIPEI 272 +P R+S E+ Sbjct: 309 GLRKEPIHRVSAAEL 323 >6FER-A nrPDB Length = 309 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 109/295 (36%), Gaps = 40/295 (13%) Query: 22 YDFVKDIGSGNFGVARLM--------RDKL--------TKELVAVKYIERG--DKIDENV 63 F + +G G FG L +DK LVAVK + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA----------GRF 113 +EI L+ PNI+ V +T L +I EY G+L + + Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTV 130 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ 173 S +F Q+ SG+ Y S+ HRDL N L+ + +KI DFG S++ Sbjct: 131 SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN--YTIKIADFGMSRNLYSGDY 188 Query: 174 PK---STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYV--MLVGAYPFEDPEEPRDYR 228 + V +++ E +L ++ +DVW+ GVTL+ P+ + + Sbjct: 189 YRIQGRAVLPIRWMSWESILLGKFTT-ASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 Query: 229 KTIQ--RILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 T + R + +P L+ + D R S EI H L+ Sbjct: 248 NTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI--HLLLLQQ 300 >5EG3-A nrPDB Length = 334 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 112/296 (37%), Gaps = 38/296 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM------RDKLTK-ELVAVKYIERG--DKID 60 P D D+ K +G G FG + +DK + VAVK ++ +K Sbjct: 25 PEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 84 Query: 61 ENVQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------- 112 ++ E+ + + +H NI+ L +I+ YAS G L E + Sbjct: 85 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSP 144 Query: 113 ---------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 + + QL G+ Y S + HRDL N L+ + +KI DFG Sbjct: 145 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV--MKIADFG 202 Query: 164 YSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ K T ++APE L + Y + +DVWS GV ++ + G P+ Sbjct: 203 LARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQ-SDVWSFGVLMWEIFTLGGSPYP 261 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 + ++L + + + E ++ + A P+ R + ++ Sbjct: 262 GIPVEELF-----KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4XUF-A nrPDB Length = 297 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 105/294 (35%), Gaps = 42/294 (14%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRD---KLTK--ELVAVKYIERGDKIDEN--VQ 64 D+ + +F K +GSG FG T VAVK ++ E + Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 60 Query: 65 REIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARF-- 120 E+ L H NIV + +I EY G+L + +FSEDE + Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 120 Query: 121 --------------------FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKIC 160 F Q+ G+ + HRDL N L+ +KIC Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKV--VKIC 178 Query: 161 DFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAY 216 DFG ++ + S ++APE L Y K +DVWS G+ L+ + G Sbjct: 179 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVN 237 Query: 217 PFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 P+ ++ K IQ + + + E ++ + D R S P Sbjct: 238 PYPGIPVDANFYKLIQN----GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 287 >2OGV-A nrPDB Length = 317 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 99/285 (34%), Gaps = 29/285 (10%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-----VAVKYIERGDKIDEN-- 62 P + + F K +G+G FG + VAVK ++ DE Sbjct: 28 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 87 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA----------G 111 + E+ L +H NIV + +I EY G+L + Sbjct: 88 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 112 RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH 171 + F Q+ G+++ S HRD+ N LL KI DFG ++ + Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLARDIMND 205 Query: 172 SQP---KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDY 227 S + ++APE + Y + +DVWS G+ L+ + G P+ + Sbjct: 206 SNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGILVNSKF 264 Query: 228 RKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 K + Y + ++ + +P R + +I Sbjct: 265 YKLV----KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >4HVI-A nrPDB Length = 314 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 69/278 (24%), Positives = 104/278 (37%), Gaps = 25/278 (8%) Query: 14 PIMHDSDRYDFVKDIGSGNFGVARLMR----DKLTKELVAVKYIE-RGDKIDENVQREII 68 P + + ++ +G GNFG L R T LVAVK ++ G + QREI Sbjct: 4 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 63 Query: 69 NHRSLRHPNIVRFKEVILTPTH--LAIIMEYASGGELYERICNAG-RFSEDEARFFFQQL 125 ++L IV+++ V P L ++MEY G L + + R + Q+ Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQI 123 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV----GTP 181 G+ Y S + HRDL N L++ +KI DFG +K L Sbjct: 124 CKGMEYLGSRRCVHRDLAARNILVESE--AHVKIADFGLAKLLPLDKDYYVVREPGQSPI 181 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV----GAYP------FEDPEEPRDYRKTI 231 + APE L + + +DVWS GV LY + P E + Sbjct: 182 FWYAPESLSDNIF-SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRL 240 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 +L +P E L+ + P R S Sbjct: 241 LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSF 278 >5X02-A nrPDB Length = 347 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 105/294 (35%), Gaps = 42/294 (14%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRD---KLTK--ELVAVKYIERGDKIDEN--VQ 64 D+ + +F K +GSG FG T VAVK ++ E + Sbjct: 40 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 99 Query: 65 REIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARF-- 120 E+ L H NIV + +I EY G+L + +FSEDE + Sbjct: 100 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 159 Query: 121 --------------------FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKIC 160 F Q+ G+ + HRDL N L+ +KIC Sbjct: 160 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKV--VKIC 217 Query: 161 DFGYSKSSVLHSQPKSTVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAY 216 DFG ++ + S ++APE L Y K +DVWS G+ L+ + G Sbjct: 218 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVN 276 Query: 217 PFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 P+ ++ K IQ + + + E ++ + D R S P Sbjct: 277 PYPGIPVDANFYKLIQN----GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 326 >2ZMD-A nrPDB Length = 390 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 111/290 (38%), Gaps = 27/290 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSL--RHP 76 Y +K IGSG + + K++ A+KY+ + ++ + + EI L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 117 KIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 175 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLRQE 193 I H DLK N L+ LK+ DFG + + S VG Y+ PE + Sbjct: 176 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMS 232 Query: 194 YD----------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +DVWS G LY M G PF+ I + + PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPD 291 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 + ++ DP RISIPE+ H + + P + M + T Sbjct: 292 IPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 339 >5AP3-A nrPDB Length = 313 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 112/290 (38%), Gaps = 27/290 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSL--RHP 76 Y +K IGSG + + K++ A+KY+ + ++ + + EI L Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 I+R + +T ++ ++ME +L + E + +++ +L V H Sbjct: 89 KIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 147 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLLRQE 193 I H DLK N L+ LK+ DFG + + S VGT Y+ PE + Sbjct: 148 IVHSDLKPANFLI---VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 204 Query: 194 YD----------GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 +DVWS G LY M G PF+ I + + PD Sbjct: 205 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPD 263 Query: 244 DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL-KNLPADLMNESNT 292 + ++ DP RISIPE+ H + + P + M + T Sbjct: 264 IPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 311 >4F0G-A nrPDB Length = 287 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 74/277 (26%), Positives = 121/277 (43%), Gaps = 22/277 (7%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--------NVQ 64 +P + D++ ++ K IG G FG+ R K +VA+K + GD E Q Sbjct: 13 LPTLADNE-IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQ 71 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQ 123 RE+ +L HPNIV+ ++ P ++ME+ G+LY R+ A Sbjct: 72 REVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLML 129 Query: 124 QLLSGVSYCHSMQ--ICHRDLKLENTL---LDGSPAPRLKICDFGYSKSSVLHSQPKSTV 178 + G+ Y + I HRDL+ N LD + K+ DFG S+ SV + Sbjct: 130 DIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--SVSGLL 187 Query: 179 GTPAYIAPEVL-LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 G ++APE + +E + AD +S + LY +L G PF++ + + R + Sbjct: 188 GNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGL 247 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + +IP+D P ++I + DP R I Sbjct: 248 RPTIPED--CPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >5TE0-A nrPDB Length = 347 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 129/327 (39%), Gaps = 37/327 (11%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV-QREIINHRSLR-HPNIVR 80 + + G F + L+R A+K + ++ D V +REI R L H NIV Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVG 80 Query: 81 FKEVILTPT------HLAIIMEYASGGELYERICNA--GRFSEDEARFFFQQLLSGVSYC 132 + + + + I+M++ GG++ + F+E+E F V+ Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARL 140 Query: 133 HSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTP 181 H + I HRDLK+EN LL +CDFG + + + Q + T Sbjct: 141 HQCKTPIIHRDLKVENILL--HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 182 AYIAPEV--LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 +Y APE+ L + AD+W+ G LY + PF + + I + Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA---------ICDGNF 249 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSW--FLKNLPADLMNESNTGSQFQ 297 +IPD+ R S + LI + DP R I ++ S+ K P + S ++ Sbjct: 250 TIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLP 309 Query: 298 EPEQPMQSLDTIMQIISEATIPAVRNR 324 EP + ++ Q + T P Sbjct: 310 EPVKASEAAAKKTQPKARLTDPIPTTE 336 >3BEA-A nrPDB Length = 333 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 101/289 (34%), Gaps = 33/289 (11%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-----VAVKYIERGDKIDEN-- 62 P + + F K +G+G FG + VAVK ++ DE Sbjct: 36 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 95 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--------- 112 + E+ L +H NIV + +I EY G+L + R Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFA 155 Query: 113 -----FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS 167 S + F Q+ G+++ S HRD+ N LL KI DFG ++ Sbjct: 156 IANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLARD 213 Query: 168 SVLHSQP---KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEE 223 + S + ++APE + Y + +DVWS G+ L+ + G P+ Sbjct: 214 IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGILV 272 Query: 224 PRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + K + Y + ++ + +P R + +I Sbjct: 273 NSKFYKLV----KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >5HI2-A nrPDB Length = 283 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 105/266 (39%), Gaps = 16/266 (6%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + + IGSG+FG + VAVK + + + + E+ R R Sbjct: 15 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--TPQQLQAFKNEVGVLRKTR 69 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCH 133 H NI+ F T LAI+ ++ G LY + + +F + +Q G+ Y H Sbjct: 70 HVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLH 128 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYS----KSSVLHSQPKSTVGTPAYIAPEVL 189 + I HRDLK N L +KI DFG + + S H Q + G+ ++APEV+ Sbjct: 129 AKSIIHRDLKSNNIFLHEDNT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVI 185 Query: 190 LRQEY--DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 Q+ +DV++ G+ LY ++ G P+ + + + R Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNC 245 Query: 248 SPECCHLISRIFVADPATRISIPEIK 273 L++ R S P I Sbjct: 246 PKRMKRLMAECLKKKRDERPSFPRIL 271 >5FM2-A nrPDB Length = 355 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 109/299 (36%), Gaps = 43/299 (14%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDE--NVQ 64 D K +G G FG + + VAVK ++ E ++ Sbjct: 56 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLL 115 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR------------ 112 E + + HP++++ L +I+EYA G L + + + Sbjct: 116 SEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 175 Query: 113 ------------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKIC 160 + + F Q+ G+ Y M++ HRDL N L+ + ++KI Sbjct: 176 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV--AEGRKMKIS 233 Query: 161 DFGYSKS-SVLHSQPKSTVG--TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAY 216 DFG S+ S K + G ++A E L Y + +DVWS GV L+ ++ G Sbjct: 234 DFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ-SDVWSFGVLLWEIVTLGGN 292 Query: 217 PFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 P+ R + +L + + S E L+ + + +P R +I Sbjct: 293 PYPGIPPERLF-----NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 346 >3ZBF-A nrPDB Length = 322 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 115/306 (37%), Gaps = 28/306 (9%) Query: 8 TGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR-----DKLTKEL-VAVKYIERGDKIDE 61 G ++ ++ +GSG FG + E+ VAVK +++G E Sbjct: 21 QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 80 Query: 62 N--VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-------R 112 +E HPNI++ V L II+E GG+L + A Sbjct: 81 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPL 140 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL---DGSPAPRLKICDFGYSK--- 166 + + + G Y M HRDL N L+ D + +KI DFG ++ Sbjct: 141 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 200 Query: 167 SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPR 225 + + + + ++APE L+ + + +DVWS G+ ++ +L G P+ Sbjct: 201 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQ-SDVWSFGILIWEILTLGHQPYPAHSNLD 259 Query: 226 DYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPAD 285 + + + + +L+++ + +P R + I+ +N + Sbjct: 260 -----VLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN 314 Query: 286 LMNESN 291 + +S Sbjct: 315 SIYKSR 320 >3BBT-B nrPDB Length = 328 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 115/293 (39%), Gaps = 23/293 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELV----AVKYIER--GDKIDENVQREIINHRSLR 74 VK +GSG FG E V A+K + G K + E + S+ Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMD 75 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCH 133 HP++VR V L+PT + ++ + G L E + + Q+ G+ Y Sbjct: 76 HPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 134 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLL 190 ++ HRDL N L+ +KI DFG ++ + + G ++A E + Sbjct: 135 ERRLVHRDLAARNVLVKS--PNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +++ + +DVWS GVT++ M G P++ I +L +P + Sbjct: 193 YRKFTHQ-SDVWSYGVTIWELMTFGGKPYDGIPTRE-----IPDLLEKGERLPQPPICTI 246 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSW--FLKNLPADLMNESNTGSQFQEPE 300 + ++ + ++ D +R E + ++ L+ + + + P Sbjct: 247 DVYMVMVKCWMIDADSRPKFKE-LAAEFSRMARDPQRYLVIQGDDRMKLPSPN 298 >4Y83-A nrPDB Length = 332 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 10/249 (4%) Query: 30 SGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPT 89 G FG L +D TK+ +A K I +D+ ++ RH NI +L Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIP----VDQFKPSDVEIQACFRHENIAELYGAVLWGE 138 Query: 90 HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL 149 + + ME GG + E++ + G E E + + +L G+ + HS ++ H D+K N + Sbjct: 139 TVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF 198 Query: 150 DGSPAPRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTL 208 + A + DFG S PK GT Y++PEV+L + + K AD++S G TL Sbjct: 199 MSTKAV---LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTK-ADIYSLGATL 254 Query: 209 YVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-RISPECCHLISRIFVADPATRI 267 M G P+ Y + I + D SP LI +P R Sbjct: 255 IHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRP 314 Query: 268 SIPEIKTHS 276 ++ H Sbjct: 315 RAADLLKHE 323 >5B2L-A nrPDB Length = 324 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 118/272 (43%), Gaps = 18/272 (6%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE--NVQREI-INHRSLRHP 76 + + + ++GSG G MR + T ++AVK + R +E + ++ + +S P Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNA--GRFSEDEARFFFQQLLSGVSYC-H 133 IV+ +T T + I ME G E++ G E ++ + Y Sbjct: 77 YIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL---- 189 + HRD+K N LLD ++K+CDFG S V + G AY+APE + Sbjct: 135 KHGVIHRDVKPSNILLDE--RGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 190 -LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 + +YD + ADVWS G++L + G +P+++ + D+ + + +P + S Sbjct: 193 PTKPDYDIR-ADVWSLGISLVELATGQFPYKNCK--TDFEVLTKVLQEEPPLLPGHMGFS 249 Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLK 280 + + D R ++ HS+ + Sbjct: 250 GDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 281 >3KRL-A nrPDB Length = 335 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 100/291 (34%), Gaps = 35/291 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-----VAVKYIERGDKIDEN-- 62 P + + F K +G+G FG + VAVK ++ DE Sbjct: 36 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 95 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--------- 112 + E+ L +H NIV + +I EY G+L + Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNP 155 Query: 113 -------FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYS 165 S + F Q+ G+++ S HRD+ N LL KI DFG + Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--KIGDFGLA 213 Query: 166 KSSVLHSQP---KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDP 221 + + S + ++APE + Y + +DVWS G+ L+ + G P+ Sbjct: 214 RDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQ-SDVWSYGILLWEIFSLGLNPYPGI 272 Query: 222 EEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + K + Y + ++ + +P R + +I Sbjct: 273 LVNSKFYKLV----KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >4XLV-A nrPDB Length = 328 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 109/291 (37%), Gaps = 35/291 (12%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARL--MRDKLTKE---LVAVKYIERGDKIDEN--VQREI 67 ++ ++++G G+FG+ RD + E VAVK + + E E Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 93 Query: 68 INHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICN----------AGRFSEDE 117 + ++VR V+ ++ME + G+L + + + E Sbjct: 94 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 153 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQP 174 ++ G++Y ++ + HRDL N ++ +KI DFG ++ + + + Sbjct: 154 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT--VKIGDFGMTRDIYETDYYRKG 211 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQR 233 + ++APE L + +D+WS GV L+ + P++ + ++ Sbjct: 212 GKGLLPVRWMAPESLKDGVFTT-SSDMWSFGVVLWEITSLAEQPYQGLSN----EQVLKF 266 Query: 234 ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT------HSWF 278 ++ Y + L+ + +P R + EI H F Sbjct: 267 VMDGGY-LDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >4R7H-A nrPDB Length = 343 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 100/298 (33%), Gaps = 42/298 (14%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-----VAVKYIERGDKIDEN-- 62 P + + F K +G+G FG + VAVK ++ DE Sbjct: 40 PYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 99 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA----------- 110 + E+ L +H NIV + +I EY + G+L + Sbjct: 100 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSP 159 Query: 111 ------------GRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLK 158 + F Q+ G+++ S HRD+ N LL K Sbjct: 160 GQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA--K 217 Query: 159 ICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-G 214 I DFG ++ + S + ++APE + Y + +DVWS G+ L+ + G Sbjct: 218 IGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQ-SDVWSYGILLWEIFSLG 276 Query: 215 AYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 P+ + K + Y + ++ + +P R + +I Sbjct: 277 LNPYPGILVNSKFYKLV----KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >3OMV-A nrPDB Length = 307 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 114/283 (40%), Gaps = 23/283 (8%) Query: 5 PVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQ 64 P ++ IGSG+FG + VAVK ++ D E Q Sbjct: 21 PRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQ 77 Query: 65 ---REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARF 120 E+ R RH NI+ F +T +LAI+ ++ G LY+ + +F + Sbjct: 78 AFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLID 136 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKST 177 +Q G+ Y H+ I HRD+K N L +KI DFG + Q + Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFL--HEGLTVKIGDFGLATVKSRWSGSQQVEQP 194 Query: 178 VGTPAYIAPEVLLRQEYD--GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 G+ ++APEV+ Q+ + +DV+S G+ LY ++ G P+ R I ++ Sbjct: 195 TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINN----RDQIIFMV 250 Query: 236 SVKYSIPDDIRISPECCHLISR----IFVADPATRISIPEIKT 274 Y+ PD ++ C + R R P+I + Sbjct: 251 GRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILS 293 >5HIE-A nrPDB Length = 302 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 110/270 (40%), Gaps = 24/270 (8%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR 74 + + IGSG+FG + VAVK + + + + E+ R R Sbjct: 31 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--TPQQLQAFKNEVGVLRKTR 85 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCH 133 H NI+ F T LAI+ ++ G LY + +F + +Q G+ Y H Sbjct: 86 HVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLH 144 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYS----KSSVLHSQPKSTVGTPAYIAPEVL 189 + I HRDLK N L +KI DFG + + S H Q + G+ ++APEV+ Sbjct: 145 AKSIIHRDLKSNNIFLHEDLT--VKIGDFGLATVKSRWSGSH-QFEQLSGSILWMAPEVI 201 Query: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 + +DV++ G+ LY ++ G P+ + R I ++ Y PD ++ Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN----RDQIIFMVGRGYLSPDLSKV 257 Query: 248 SPEC----CHLISRIFVADPATRISIPEIK 273 C L++ R P+I Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >5U6B-A nrPDB Length = 307 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 118/312 (37%), Gaps = 47/312 (15%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL--VAVKYIERGDKID---ENVQREIIN 69 +M D + K +G G FG + + VAVK ++ E+ E + Sbjct: 18 VMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVC 77 Query: 70 HRSLRHPNIVRFKEVILTPTHL------AIIMEYASGGELYERIC------NAGRFSEDE 117 + HPN++R V + +I+ + G+L+ + Sbjct: 78 MKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQM 137 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQP 174 F + SG+ Y + + HRDL N +L+ + + + + DFG SK + Q Sbjct: 138 LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMS--VCVADFGLSKKIYNGDYYRQG 195 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQR 233 + +IA E L + Y K +DVWS GVT++ + G P+ E Y Q Sbjct: 196 RIAKMPVKWIAIESLADRVYTSK-SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQG 254 Query: 234 ILSVKYSIPDDIRISPECCH----LISRIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 + ++ +C L+SR + +P R S E++ DL N Sbjct: 255 ---------NRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE----------DLENT 295 Query: 290 SNTGSQFQEPEQ 301 QEP++ Sbjct: 296 LKALPPAQEPDE 307 >3LZB-A nrPDB Length = 327 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 107/263 (40%), Gaps = 20/263 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELV----AVKYIER--GDKIDENVQREIINHRSLR 74 + +K +GSG FG E V A+K + K ++ + E S+ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 75 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCH 133 +P++ R + LT T + +I + G L + + + Q+ G++Y Sbjct: 76 NPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 134 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLL 190 ++ HRDL N L+ +KI DFG +K + G ++A E +L Sbjct: 135 DRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + Y + +DVWS GVT++ M G+ P++ I IL +P + Sbjct: 193 HRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-----ISSILEKGERLPQPPICTI 246 Query: 250 ECCHLISRIFVADPATRISIPEI 272 + ++ + ++ D +R E+ Sbjct: 247 DVYMIMRKCWMIDADSRPKFREL 269 >4C59-A nrPDB Length = 340 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 124/310 (40%), Gaps = 43/310 (13%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI-ERGDKIDENVQREIINHRSLR-HPNI 78 R + + G F +D + A+K + ++ + + +E+ + L HPNI Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNI 87 Query: 79 VRF--------KEVILTPTHLAIIMEYASGGELYERICN---AGRFSEDEARFFFQQLLS 127 V+F +E ++ E G+L E + G S D F Q Sbjct: 88 VQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKKMESRGPLSCDTVLKIFYQTCR 146 Query: 128 GVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---------- 175 V + H + I HRDLK+EN LL +K+CDFG + + + Sbjct: 147 AVQHMHRQKPPIIHRDLKVENLLLSNQGT--IKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 176 ---STVGTPAYIAPEVL-LRQEYD-GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT 230 + TP Y PE++ L + G+ D+W+ G LY++ +PFED + Sbjct: 205 EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL------ 258 Query: 231 IQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNES 290 RI++ KYSIP LI + +P R+SI E+ H + A +N Sbjct: 259 --RIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVV-HQ-LQEIAAARNVNPK 314 Query: 291 NTGSQFQEPE 300 + ++ E Sbjct: 315 SPITELLEQN 324 >2WO6-A nrPDB Length = 382 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 83/330 (25%), Positives = 115/330 (34%), Gaps = 72/330 (21%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHP-- 76 DRY+ IG G+FG D++ +E VA+K I+ Q E+ + +H Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 77 ---NIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSY 131 IV K + HL ++ E S LY+ + N S + R F QQ+ + + + Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 132 CH--SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 + I H DLK EN LL +KI DFG S L + + + Y +PEVL Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSS--CQLGQRIYQYIQSRFYRSPEVL 230 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK-------------------- 229 L YD D+WS G L M G F E K Sbjct: 231 LGMPYDL-AIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR 289 Query: 230 -----------------------------TIQRILSVKYSIPDDIRISP---------EC 251 + IL V+ P R + Sbjct: 290 KFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKF 349 Query: 252 CHLISRIFVADPATRISIPEIKTHSWFLKN 281 LI R+ DP TRI HS+F K Sbjct: 350 KDLILRMLDYDPKTRIQPYYALQHSFFKKT 379 >4MD7-E nrPDB Length = 391 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 130/344 (37%), Gaps = 41/344 (11%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + D Y V+ +G G + + E V + ++REI +LR Sbjct: 33 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV--VKILKPVKKKKIKREIKILENLRG 90 Query: 76 -PNIVRFKEVILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 PNI+ +++ P A++ E+ + + + ++ + RF+ ++L + YC Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 147 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HSM I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIPDD 244 + D+WS G L M+ PF + D I ++L KY+I D Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 245 IR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 R +SPE + ++ D +R++ E H +F Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 Query: 281 NLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNR 324 + S++ EP + I + + + Sbjct: 327 VVKDQARMGSSSMPGGSEPVSSANMMSGISSVPEPEPLGPLAGE 370 >4TPT-A nrPDB Length = 303 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 122/271 (45%), Gaps = 30/271 (11%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIER-GDKIDENVQREIINHRSLRHPNIVRFKE 83 + +G G FG A + K T +++ +K + R ++ + E+ RSL HPN+++F Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 V+ L ++ EY GG L + + + F + F + + SG++Y HSM I HRDL Sbjct: 65 VLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLN 124 Query: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHS---------------------QPKSTVGTPA 182 N L+ + + DFG S+ V + + VG P Sbjct: 125 SHNCLIKLDKT--VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE-PRDYRKTIQRILSVKYSI 241 ++APE+L + YD + D++S G+ L ++ G + DP+ PR + L + + Sbjct: 183 WMAPEMLNGKSYD-ETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKLFWEKFV 239 Query: 242 PDDIRISPECCHLISRIFVADPATRISIPEI 272 P D P L + +P +R + ++ Sbjct: 240 PTD--CPPAFFPLAAICCRLEPESRPAFSKL 268 >3PLS-A nrPDB Length = 298 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 65/258 (25%), Positives = 110/258 (42%), Gaps = 21/258 (8%) Query: 26 KDIGSGNFGVAR--LMRDKLTKEL-VAVKYIERGDKID--ENVQREIINHRSLRHPNIVR 80 + IG G+FGV D+ + A+K + R ++ E RE + R L HPN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 81 FKEVILTPTHL-AIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSMQIC 138 ++L P L +++ Y G+L + I + R + + F Q+ G+ Y + Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFV 146 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 HRDL N +LD S +K+ DFG + + Q + + A E L Sbjct: 147 HRDLAARNCMLDESFT--VKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 194 YDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 + K +DVWS GV L+ +L GA P+ + + L+ +P Sbjct: 205 FTTK-SDVWSFGVLLWELLTRGAPPYRHIDPFD-----LTHFLAQGRRLPQPEYCPDSLY 258 Query: 253 HLISRIFVADPATRISIP 270 ++ + + ADPA R + Sbjct: 259 QVMQQCWEADPAVRPTFR 276 >5GNK-A nrPDB Length = 297 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 108/263 (41%), Gaps = 20/263 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELV----AVKYIER--GDKIDENVQREIINHRSLR 74 + +K +GSG FG E V A+K + K ++ + E S+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCH 133 +P++ R + LT T + +IM+ G L + + + Q+ G++Y Sbjct: 80 NPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 138 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLL 190 ++ HRDL N L+ +KI DFG +K + G ++A E +L Sbjct: 139 DRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 + Y + +DVWS GVT++ M G+ P++ I IL +P + Sbjct: 197 HRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-----ISSILEKGERLPQPPICTI 250 Query: 250 ECCHLISRIFVADPATRISIPEI 272 + ++ + ++ D +R E+ Sbjct: 251 DVYMIMVKCWMIDADSRPKFREL 273 >3QUP-A nrPDB Length = 323 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 97/277 (35%), Gaps = 30/277 (10%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTK---ELVAVKYIERG---DKIDENVQREII 68 ++ ++ + +G G FG R + K VAVK ++ E RE Sbjct: 18 VLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAA 77 Query: 69 NHRSLRHPNIVRFKEVILT---PTHLAI---IMEYASGGELYERIC------NAGRFSED 116 + HP++ + V L L I I+ + G+L+ + N Sbjct: 78 CMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQ 137 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS 176 F + G+ Y S HRDL N +L + + DFG S+ + Sbjct: 138 TLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMT--VCVADFGLSRKIYSGDYYRQ 195 Query: 177 TVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQ 232 + ++A E L Y +DVW+ GVT++ M G P+ E Y I Sbjct: 196 GCASKLPVKWLALESLADNLYTV-HSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI- 253 Query: 233 RILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 + E L+ + + ADP R S Sbjct: 254 ----GGNRLKQPPECMEEVYDLMYQCWSADPKQRPSF 286 >3CJF-A nrPDB Length = 309 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 113/286 (39%), Gaps = 32/286 (11%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLM----RDK-LTKELVAVKYIERGDKIDEN--VQREI 67 DR + K +G G FG DK T VAVK ++ G E+ + E+ Sbjct: 22 WEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 81 Query: 68 INHRSL-RHPNIVRFKEVILTPT-HLAIIMEYASGGELYERICNAGR------------F 113 + H N+V P L +I+E+ G L + + Sbjct: 82 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFL 141 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVL 170 + + + Q+ G+ + S + HRDL N LL +KICDFG ++ Sbjct: 142 TLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNV--VKICDFGLARDIYKDPD 199 Query: 171 HSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRK 229 + + ++APE + + Y + +DVWS GV L+ + GA P+ + ++ + Sbjct: 200 YVRKGDARLPLKWMAPETIFDRVYTIQ-SDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 258 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 ++ + PD +PE + + +P+ R + E+ H Sbjct: 259 RLKE--GTRMRAPDYT--TPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >6HMD-A nrPDB Length = 365 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 118/302 (39%), Gaps = 41/302 (13%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 +P + D Y V+ +G G + + E V + ++RE+ Sbjct: 45 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV--VKILKPVKKKKIKREVKILE 102 Query: 72 SLRH-PNIVRFKEVILTP--THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 +LR NI++ + + P A++ EY + + + ++ + RF+ +LL Sbjct: 103 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKA 159 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 + YCHS I HRD+K N ++D +L++ D+G ++ + V + + PE+ Sbjct: 160 LDYCHSKGIMHRDVKPHNVMID-HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 218 Query: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYS 240 L+ + D+WS G L M+ PF ++ D I ++L KY Sbjct: 219 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 278 Query: 241 IPDDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHS 276 I D +SPE L+ ++ D R++ E H Sbjct: 279 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 338 Query: 277 WF 278 +F Sbjct: 339 YF 340 >4G3E-A nrPDB Length = 352 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 69/253 (27%), Positives = 106/253 (41%), Gaps = 15/253 (5%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT 87 +G G+FG M+DK T AVK + E E++ L P IV + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE----ELVACAGLSSPRIVPLYGAVRE 137 Query: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENT 147 + I ME GG L + I G ED A ++ Q L G+ Y H+ +I H D+K +N Sbjct: 138 GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNV 197 Query: 148 LLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVLLRQEYDGKIADV 201 LL R +CDFG++ KS + GT ++APEV++ + D K D+ Sbjct: 198 LLSSDG-SRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAK-VDI 255 Query: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVA 261 WS + ML G +P+ K ++ P ++ + I Sbjct: 256 WSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQA---IQEGLRK 312 Query: 262 DPATRISIPEIKT 274 +P R S E++ Sbjct: 313 EPVHRASAMELRR 325 >3G0E-A nrPDB Length = 336 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 101/295 (34%), Gaps = 37/295 (12%) Query: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDEN-- 62 P D +R F K +G+G FG VAVK ++ + E Sbjct: 36 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA 95 Query: 63 VQREIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG---------- 111 + E+ L H NIV +I EY G+L + Sbjct: 96 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 112 --------RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 ++ F Q+ G+++ S HRDL N LL KICDFG Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT--KICDFG 213 Query: 164 YSKSSVLHSQP---KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFE 219 ++ S + ++APE + Y + +DVWS G+ L+ + G+ P+ Sbjct: 214 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFE-SDVWSYGIFLWELFSLGSSPYP 272 Query: 220 DPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + K I + + E ++ + ADP R + +I Sbjct: 273 GMPVDSKFYKMI----KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >5HLW-A nrPDB Length = 299 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 65/265 (24%), Positives = 107/265 (40%), Gaps = 25/265 (9%) Query: 23 DFVKDIGSGNFGVAR---LMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPN 77 F + IG G+FG L+ + K AVK + R I E E I + HPN Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 82 Query: 78 IVRFKEVIL-TPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSM 135 ++ + L + +++ Y G+L I N + + F Q+ G+ Y S Sbjct: 83 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASK 142 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT-----PAYIAPEVLL 190 + HRDL N +LD +K+ DFG ++ T ++A E L Sbjct: 143 KFVHRDLAARNCMLDEKFT--VKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 191 RQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRI 247 Q++ K +DVWS GV L+ ++ GA P+ D + Y +R+L +Y + Sbjct: 201 TQKFTTK-SDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 259 Query: 248 SPECCHLISRIFVADPATRISIPEI 272 + + + R S E+ Sbjct: 260 -------MLKCWHPKAEMRPSFSEL 277 >3C1X-A nrPDB Length = 373 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 107/265 (40%), Gaps = 25/265 (9%) Query: 23 DFVKDIGSGNFGVAR---LMRDKLTKELVAVKYIERGDKIDE--NVQREIINHRSLRHPN 77 F + IG G+FG L+ + K AVK + R I E E I + HPN Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 151 Query: 78 IVRFKEVIL-TPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSM 135 ++ + L + +++ Y G+L I N + + F Q+ G+ + S Sbjct: 152 VLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASK 211 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT-----PAYIAPEVLL 190 + HRDL N +LD +K+ DFG ++ T ++A E L Sbjct: 212 KFVHRDLAARNCMLDEKFT--VKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 191 RQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRI 247 Q++ K +DVWS GV L+ ++ GA P+ D + Y +R+L +Y + Sbjct: 270 TQKFTTK-SDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 328 Query: 248 SPECCHLISRIFVADPATRISIPEI 272 + + + R S E+ Sbjct: 329 -------MLKCWHPKAEMRPSFSEL 346 >1U59-A nrPDB Length = 287 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 103/253 (40%), Gaps = 19/253 (7%) Query: 27 DIGSGNFGVARLMRDKLTKEL--VAVKYIERGDKI--DENVQREIINHRSLRHPNIVRFK 82 ++G GNFG R ++ K+ VA+K +++G + E + RE L +P IVR Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 83 EVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 V L ++ME A GG L++ + Q+ G+ Y HRD Sbjct: 77 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 135 Query: 142 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLRQEYDGK 197 L N LL KI DFG SK+ + + APE + +++ + Sbjct: 136 LAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 198 IADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 +DVWS GVT++ + G P++ + P Q + P + PE L+S Sbjct: 194 -SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ---GKRMECPPE--CPPELYALMS 247 Query: 257 RIFVADPATRISI 269 ++ R Sbjct: 248 DCWIYKWEDRPDF 260 >3PP0-A nrPDB Length = 338 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 108/263 (41%), Gaps = 20/263 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELV----AVKYIER--GDKIDENVQREIINHRSLR 74 VK +GSG FG E V A+K + K ++ + E + Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG 77 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCH 133 P + R + LT T + ++ + G L + + N GR + + Q+ G+SY Sbjct: 78 SPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLE 136 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPEVLL 190 +++ HRDL N L+ +KI DFG ++ + G ++A E +L Sbjct: 137 DVRLVHRDLAARNVLVKS--PNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 R+ + + +DVWS GVT++ M GA P++ I +L +P + Sbjct: 195 RRRFTHQ-SDVWSYGVTVWELMTFGAKPYDGIPARE-----IPDLLEKGERLPQPPICTI 248 Query: 250 ECCHLISRIFVADPATRISIPEI 272 + ++ + ++ D R E+ Sbjct: 249 DVYMIMVKCWMIDSECRPRFREL 271 >5GRN-A nrPDB Length = 356 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 107/305 (35%), Gaps = 49/305 (16%) Query: 10 PLDMP----IMHDSDRYDFVKDIGSGNFGVARL--MRDKLTKE---LVAVKYIERGDKID 60 P+ +P D + +GSG FG + VAVK ++ + Sbjct: 32 PMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS 91 Query: 61 EN--VQREIINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC--------- 108 E + E+ L H NIV + II EY G+L + Sbjct: 92 EKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSH 151 Query: 109 -----------------NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDG 151 N+ + + F Q+ G+ + S HRDL N LL Sbjct: 152 KKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-- 209 Query: 152 SPAPRLKICDFGYSKSSVLHSQPKSTVGT---PAYIAPEVLLRQEYDGKIADVWSCGVTL 208 + +KICDFG ++ + S S T ++APE + Y ++DVWS G+ L Sbjct: 210 AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTT-LSDVWSYGILL 268 Query: 209 YVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRI 267 + + G P+ + I Y + + E ++ + + ++P R Sbjct: 269 WEIFSLGGTPYPGMMVDSTFYNKI----KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRP 324 Query: 268 SIPEI 272 S + Sbjct: 325 SFYHL 329 >2OZO-A nrPDB Length = 613 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 63/253 (24%), Positives = 103/253 (40%), Gaps = 19/253 (7%) Query: 27 DIGSGNFGVARLMRDKLTKEL--VAVKYIERGDKI--DENVQREIINHRSLRHPNIVRFK 82 ++G GNFG R ++ K+ VA+K +++G + E + RE L +P IVR Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 83 EVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 V L ++ME A GG L++ + Q+ G+ Y HR+ Sbjct: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRN 461 Query: 142 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLRQEYDGK 197 L N LL KI DFG SK+ + + APE + +++ + Sbjct: 462 LAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 Query: 198 IADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 +DVWS GVT++ + G P++ + P Q + P + PE L+S Sbjct: 520 -SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ---GKRMECPPE--CPPELYALMS 573 Query: 257 RIFVADPATRISI 269 ++ R Sbjct: 574 DCWIYKWEDRPDF 586 >6FYV-A nrPDB Length = 337 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 108/322 (33%), Gaps = 68/322 (21%) Query: 21 RYDFVKDIGSGNFGVARLMRDKL-TKELVAVKYIERGDKIDENVQREIINHRSLRH--PN 77 RY+ V +G G FG D VAVK ++ + E + EI L PN Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 78 ----IVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSY 131 V+ E H+ I+ E G Y+ I F D R Q+ +++ Sbjct: 75 SVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQSINF 133 Query: 132 CHSMQICHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHSQP 174 H ++ H DLK EN L S +K+ DFG + Sbjct: 134 LHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--DDEHH 191 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY------- 227 + V T Y APEV+L + + DVWS G L +G F+ + Sbjct: 192 STLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 250 Query: 228 ----RKTIQRILSVKYSIP---DDIRIS------------------------PECCHLIS 256 + IQ+ KY D S + L+ Sbjct: 251 GPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVR 310 Query: 257 RIFVADPATRISIPEIKTHSWF 278 R+ DP RI++ E H +F Sbjct: 311 RMLEYDPTQRITLDEALQHPFF 332 >2WTK-B nrPDB Length = 373 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 115/316 (36%), Gaps = 60/316 (18%) Query: 22 YDFVKDIGSGNF---GVARLMRDKLTKELVAVKYIERGDKIDENV---QREIINHRSLRH 75 Y+ + IG G F L R K T E V V+ I +E V Q E+ + H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNA--GRFSEDEARFFFQQLLSGVSYCH 133 PNIV ++ + L ++ + + G + IC +E + Q +L + Y H Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 134 SMQICHRDLKLENTLLDGSP-------APRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 M HR +K + L+ L + G + V+H PK +V +++P Sbjct: 130 HMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG-QRQRVVHDFPKYSVKVLPWLSP 188 Query: 187 EVLLR--QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV------- 237 EVL + Q YD K +D++S G+T + G PF+D + + + + Sbjct: 189 EVLQQNLQGYDAK-SDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTI 247 Query: 238 ---------------------------------KYSIPDDIRISPECCHLISRIFVADPA 264 S P SP H + + +P Sbjct: 248 PAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPD 307 Query: 265 TRISIPEIKTHSWFLK 280 R S + HS+F + Sbjct: 308 ARPSASTLLNHSFFKQ 323 >6EII-A nrPDB Length = 352 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 119/298 (39%), Gaps = 41/298 (13%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + D Y V+ +G G + + E V + ++REI +LR Sbjct: 56 WGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV--VKILKPVKKKKIKREIKILENLRG 113 Query: 76 -PNIVRFKEVILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 PNI+ +++ P A++ E+ + + + ++ + RF+ ++L + YC Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 170 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HSM I HRD+K N ++D +L++ D+G ++ + V + + PE+L+ Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHR-KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSIPDD 244 + D+WS G L M+ PF + D I ++L KY+I D Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 245 IR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 R +SPE + ++ D +R++ E H +F Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >3RAW-A nrPDB Length = 381 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 115/331 (34%), Gaps = 70/331 (21%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKE-LVAVKYIERGDKIDENVQREIINHRSLRH--- 75 +RY+ V ++G G FG D + VA+K I K E + EI + ++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 76 PN---IVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFFQQLLSGVS 130 N V + H+ I E G +E + N + R QL + Sbjct: 111 ENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 131 YCHSMQICHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHSQ 173 + H Q+ H DLK EN L S +++ DFG + H Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT--FDHEH 227 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 + V T Y PEV+L + + DVWS G L+ G F+ E R++ +++ Sbjct: 228 HTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQ-THENREHLVMMEK 285 Query: 234 IL------------SVKYSIP----------DDIRISPECC-----------------HL 254 IL KY D + C L Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNLPAD 285 + R+ DPA RI++ E H +F P + Sbjct: 346 MRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >5IKW-A nrPDB Length = 310 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 123/304 (40%), Gaps = 42/304 (13%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV-QREIINHRSLR-HPNIVR 80 + + G F L+R A+K + + D NV +REI + L H NIV Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVG 75 Query: 81 FKEVILTP--THLA---IIMEYASGGELYERICNA--GRFSEDEARFFFQQLLSGVSYCH 133 + + + ++ I+MEY G++ ++ F+E E F V+ H Sbjct: 76 YLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLH 135 Query: 134 SMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---------VGTPA 182 + I HRDLK+EN LL + +CDFG + + L+ Q T + Sbjct: 136 QCKTPIIHRDLKVENILL--NDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 183 YIAPEVLL--RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Y APE++ + AD+W+ G LY + PF + + I ++ Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA---------ICDGNFT 244 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF-----LKNLPADLMNESNTGSQ 295 IPD+ R S LI + DP R I ++ S+F + P +N S+ S Sbjct: 245 IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV---SYFAFKFAAADCPVSNINNSSIPSA 301 Query: 296 FQEP 299 EP Sbjct: 302 LPEP 305 >2A1A-B nrPDB Length = 284 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 68/274 (24%), Positives = 111/274 (40%), Gaps = 38/274 (13%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 + ++ IGSG FG + ++ + +K ++ +E +RE+ L H NIV Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN---NEKAEREVKALAKLDHVNIVH 68 Query: 81 FKEVILTPTH----------------LAIIMEYASGGELYERICNAG--RFSEDEARFFF 122 + + L I ME+ G L + I + + A F Sbjct: 69 YNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELF 128 Query: 123 QQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA 182 +Q+ GV Y HS ++ +RDLK N L + ++KI DFG S + + GT Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFLVDTK--QVKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRK-TIQRILSVKYS 240 Y++PE + Q+Y GK D+++ G+ L +L V FE + D R I I K Sbjct: 187 YMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKE- 244 Query: 241 IPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 L+ ++ P R + EI Sbjct: 245 -----------KTLLQKLLSKKPEDRPNTSEILR 267 >5WNO-A nrPDB Length = 330 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 112/295 (37%), Gaps = 21/295 (7%) Query: 23 DFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 K +G+G FG R K K VA+K + + + E N LRH N Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDN 84 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 +++ + L I+ Y G L + + E + Q+ SG+ Y + Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLRQE 193 + HRDL N L+ ++I DFG SK + KS ++A E+ + Sbjct: 145 VVHRDLATRNVLV--KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC 202 Query: 194 YDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 Y +DVW+ GVT + ++ G P++ +I L + S + Sbjct: 203 YTH-ASDVWAFGVTCWEIITFGQSPYQGMST-----DSIHNFLKDGNRLSQPPNCSQDLY 256 Query: 253 HLISRIFVADPATRISIPEIKTHSW--FLKNLPADLMNESNTGSQFQEPEQPMQS 305 + R ++ADP +R EI + F K L N + E+ Q+ Sbjct: 257 QELLRCWMADPKSRPGF-EILYERFKEFCKVPQLFLENSNKISESDLSAEERFQT 310 >2BUJ-A nrPDB Length = 317 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 72/281 (25%), Positives = 116/281 (41%), Gaps = 26/281 (9%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-YIERGDKIDENVQREIINHRSL 73 ++ D+ Y F++ +G G F L+ A+K + + E QRE HR Sbjct: 24 VIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLF 83 Query: 74 RHPNIVRFKEVILTPT----HLAIIMEYASGGELY---ERICNAGRF-SEDEARFFFQQL 125 HPNI+R L +++ + G L+ ER+ + G F +ED+ + + Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGI 143 Query: 126 LSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------- 178 G+ H+ HRDLK N LL P L D G + +H + Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLM--DLGSMNQACIHVEGSRQALTLQDWA 201 Query: 179 ---GTPAYIAPEVLLRQEY--DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 T +Y APE+ Q + + DVWS G LY M+ G P++ + D ++ Sbjct: 202 AQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD---SVAL 258 Query: 234 ILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + + SIP R S L++ + DP R IP + + Sbjct: 259 AVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLS 299 >4JLC-A nrPDB Length = 657 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 64/229 (27%), Positives = 98/229 (42%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G R K T +L AVK + + RE + L H NIV+ + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 75 Query: 86 L--TPTHLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY + NA E E + ++ G+++ I HR Sbjct: 76 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 135 Query: 141 DLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR------- 191 D+K N + + K+ DFG ++ Q S GT Y+ P++ R Sbjct: 136 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 195 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Q+ G D+WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 196 QKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >4LRM-A nrPDB Length = 334 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 107/266 (40%), Gaps = 23/266 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELV----AVKYIER--GDKIDENVQREIINHRSLR 74 + +K +GSG FG E V A+K + K ++ + E S+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 75 HP---NIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVS 130 +P ++ R + LT T + +I + G L + + + Q+ G++ Sbjct: 80 NPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 138 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP---AYIAPE 187 Y ++ HRDL N L+ +KI DFG +K + G ++A E Sbjct: 139 YLEDRRLVHRDLAARNVLVKTPQ--HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 196 Query: 188 VLLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 +L + Y + +DVWS GVT++ M G+ P++ I IL +P Sbjct: 197 SILHRIYTHQ-SDVWSYGVTVWELMTFGSKPYDGIPASE-----ISSILEKGERLPQPPI 250 Query: 247 ISPECCHLISRIFVADPATRISIPEI 272 + + ++ + ++ D +R E+ Sbjct: 251 CTIDVYMIMVKCWMIDADSRPKFREL 276 >4CRL-A nrPDB Length = 406 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 125/321 (38%), Gaps = 63/321 (19%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKEL--VAVKYIERGDKIDENVQREIINHRSLRHPNI 78 Y+ K G G +G + K K+ A+K IE G I + REI R L+HPN+ Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIE-GTGISMSACREIALLRELKHPNV 81 Query: 79 VRFKEVILT--PTHLAIIMEYASGGELYERIC---------NAGRFSEDEARFFFQQLLS 127 + ++V L+ + ++ +YA +L+ I + + Q+L Sbjct: 82 ISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140 Query: 128 GVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVLHSQPKS----TVGTP 181 G+ Y H+ + HRDLK N L+ +G R+KI D G+++ +P + V T Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAY-------------PFEDPEEPRDY- 227 Y APE+LL + K D+W+ G +L P+ + R + Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260 Query: 228 ---------------------------RKTIQRILSVKYSIPDDIRISPECCHLISRIFV 260 R T +KY ++ + HL+ ++ Sbjct: 261 VMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT 320 Query: 261 ADPATRISIPEIKTHSWFLKN 281 DP RI+ + +FL++ Sbjct: 321 MDPIKRITSEQAMQDPYFLED 341 >3Q4U-A nrPDB Length = 301 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 115/295 (38%), Gaps = 43/295 (14%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 + ++ +G G +G R E VAVK D+ + E+ N LRH N Sbjct: 6 VARDITLLECVGKGRYGEV--WRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN 63 Query: 78 IVRFKEVILTPTH----LAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 I+ F +T H L +I Y G LY+ + + R + SG+++ H Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR-IVLSIASGLAHLH 122 Query: 134 --------SMQICHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGT 180 I HRDLK +N L+ + + I D G + ++ L VGT Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKN--GQCCIADLGLAVMHSQSTNQLDVGNNPRVGT 180 Query: 181 PAYIAPEVLLR----QEYDG-KIADVWSCGVTLYVMLVG----------AYPFEDPEEPR 225 Y+APEVL +D K D+W+ G+ L+ + PF D Sbjct: 181 KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPND 240 Query: 226 DYRKTIQRIL---SVKYSIPDDIRISP---ECCHLISRIFVADPATRISIPEIKT 274 + +++++ + +IP+ P L+ + +P+ R++ IK Sbjct: 241 PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >2PVN-A nrPDB Length = 352 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 113/303 (37%), Gaps = 47/303 (15%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + D Y+ V+ +G G + + E ++ + L++ Sbjct: 48 WGEQDDYEVVRKVGRGKYSEVFEGINVNNNE-----KCIIKILKPVKKKKIKREIKILQN 102 Query: 76 ----PNIVRFKEVILTP--THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 PNIV+ +++ ++I EY + + ++ + R++ +LL + Sbjct: 103 LCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFK---VLYPTLTDYDIRYYIYELLKAL 159 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 YCHS I HRD+K N ++D +L++ D+G ++ + V + + PE+L Sbjct: 160 DYCHSQGIMHRDVKPHNVMIDHELR-KLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELL 218 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV--------KYSI 241 + + D+WS G M+ PF + D I ++L KY I Sbjct: 219 VDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRI 278 Query: 242 PDDIR------------------------ISPECCHLISRIFVADPATRISIPEIKTHSW 277 D + +SPE + ++ D R++ E TH + Sbjct: 279 ELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPY 338 Query: 278 FLK 280 F + Sbjct: 339 FQQ 341 >5WNL-A nrPDB Length = 342 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 23/287 (8%) Query: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKY---IERGD 57 M+ L + D+ + + +GSG FG +R K +A+K + D Sbjct: 1 MEGEGRGRWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDD 60 Query: 58 KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE 117 + + E + I+ + P + ++MEY G L E++ + D Sbjct: 61 RERMELLEEAKKMEMAKFRYILPVYGICQEP--VGLVMEYMETGSL-EKLLASEPLPWDL 117 Query: 118 ARFFFQQLLSGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLH 171 + G+++ H M + H +LK N LLD +KI DFG +K S Sbjct: 118 RFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAH--YHVKISDFGLAKCNGMSHSHD 175 Query: 172 SQPKSTVGTPAYIAPEVLLRQE--YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 GT AY+ PE + + +D K DV+S + ++ +L PF D + Sbjct: 176 LSMDGLFGTIAYLPPERIREKSRLFDTKH-DVYSFAIVIWGVLTQKKPFADEKNI--LHI 232 Query: 230 TIQRILSVKYSIPDDIRISPECCH----LISRIFVADPATRISIPEI 272 ++ + + +P R P C L+ R + ADP R + EI Sbjct: 233 MMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4EUU-A nrPDB Length = 319 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G R K T +L A+K + + RE + L H NIV+ + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 86 L--TPTHLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY + NA E E + ++ G+++ I HR Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 136 Query: 141 DLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR------- 191 ++K N + + K+ DFG ++ Q S GT Y+ P++ R Sbjct: 137 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 196 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Q+ G D+WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 197 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >4OW8-A nrPDB Length = 283 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 19/259 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 S RY + I +G G D VAVK ++ D E + E L Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 69 Query: 75 HPNIVRFKEVIL-----TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP I + ++ME +G L + GR S A +Q + Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 129 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPAYIAPE 187 H+ + HRD+K N L+ +P ++KI DFG +K+ +Q +GT YIAPE Sbjct: 130 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L + +DV+S GV Y + G PF K I+ + Sbjct: 188 QALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPL-----PPDL 241 Query: 248 SPECCHLISRIFVADPATR 266 P LI V +PA R Sbjct: 242 PPNVRELIEITLVKNPAMR 260 >6B2Q-A nrPDB Length = 317 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 103/275 (37%), Gaps = 22/275 (8%) Query: 6 VTTGPLDMP---IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-- 60 V G L M + S RY + I +G G D VAVK ++ D Sbjct: 15 VPRGSLHMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE 74 Query: 61 --ENVQREIINHRSLRHPNIVRFKEVIL-----TPTHLAIIMEYASGGELYERICNAGRF 113 E + E L HP I + ++ME +G L + GR Sbjct: 75 FIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRL 134 Query: 114 SEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LH 171 S A +Q + H+ + HRD+K N L+ +P ++KI DFG +K+ Sbjct: 135 SLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPV 192 Query: 172 SQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 +Q +GT YIAPE L + +DV+S GV Y + G PF K I Sbjct: 193 TQTGMVMGTAQYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHI 251 Query: 232 QRILSVKYSIPDDIRISPECCHLISRIFVADPATR 266 + + P LI V +PA R Sbjct: 252 KEPPPPL-----PPDLPPNVRELIEITLVKNPAMR 281 >4X3F-A nrPDB Length = 337 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 68/259 (26%), Positives = 98/259 (37%), Gaps = 19/259 (7%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID----ENVQREIINHRSLR 74 S RY + I +G G D VAVK ++ D E + E L Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 70 Query: 75 HPNIVRFKEVIL-----TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 HP I + ++ME +G L + GR S A +Q + Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRAL 130 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV--LHSQPKSTVGTPAYIAPE 187 H+ + HRD+K N L+ +P ++KI DFG +K+ +Q +GT YIAPE Sbjct: 131 QIAHAAGLVHRDVKPGNILI--TPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L + +DV+S GV Y + G PF K I+ + Sbjct: 189 QALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPL-----PPDL 242 Query: 248 SPECCHLISRIFVADPATR 266 P LI V +PA R Sbjct: 243 PPNVRELIEITLVKNPAMR 261 >5UIU-A nrPDB Length = 323 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 105/268 (39%), Gaps = 26/268 (9%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIE-----RGDKIDENVQREIINHRSLRHPNIVRF 81 +G G FGV + VAVK + +++ + +EI +H N+V Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 82 KEVILTPTHLAIIMEYASGGELYERIC---NAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 L ++ Y G L +R+ S Q +G+++ H Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAYIAPEVLLRQEYD 195 HRD+K N LLD + KI DFG +++S +Q T VGT AY+APE L + Sbjct: 172 HRDIKSANILLDEAFTA--KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-- 227 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS--------VKYSIPDDIRI 247 +D++S GV L ++ G ++ EP+ + I + + D Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 287 Query: 248 SPECC-HLISRIFVADPATRISIPEIKT 274 S E + S+ R I +++ Sbjct: 288 SVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >3MY0-A nrPDB Length = 305 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 107/289 (37%), Gaps = 43/289 (14%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 V+ +G G +G R E VAVK D+ + EI N LRH NI+ F Sbjct: 12 LVECVGKGRYGEV--WRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 84 VILT----PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH------ 133 +T T L +I Y G LY+ + A G+++ H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFL-QRQTLEPHLALRLAVSAACGLAHLHVEIFGT 128 Query: 134 --SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-----KSTVGTPAYIAP 186 I HRD K N L+ + + I D G + S VGT Y+AP Sbjct: 129 QGKPAIAHRDFKSRNVLVKSN--LQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAP 186 Query: 187 EVLLRQEYD-----GKIADVWSCGVTLYVMLVG----------AYPFEDPEEPRDYRKTI 231 EVL Q K D+W+ G+ L+ + PF D + + Sbjct: 187 EVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM 246 Query: 232 QRILSVK---YSIPDDIRISPECCHL---ISRIFVADPATRISIPEIKT 274 ++++ V +IP+ + P L + + +P+ R++ IK Sbjct: 247 KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >4NEU-A nrPDB Length = 333 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 119/308 (38%), Gaps = 28/308 (9%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREIINHRSLRHPNIVRFKE 83 ++ SG FG L + ++ +K + +G + +E + E LRH +V+ Sbjct: 31 ELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLG 89 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 VI+ +++MEY G L + +++ G+ Y H + H+DLK Sbjct: 90 VIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLK 149 Query: 144 LENTLLDGSPAPRLKICDFGYS--------------KSSVLHSQPKSTVGTPAYIAPEVL 189 EN L+D +KI D G + + + K GT Y+APE L Sbjct: 150 PENILVDND--FHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHL 207 Query: 190 LR-QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR-- 246 + +DV+S V L+ + P+E ++ I I S DDI Sbjct: 208 NDVNAKPTEKSDVYSFAVVLWAIFANKEPYE---NAICEQQLIMCIKSGNRPDVDDITEY 264 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTH--SWFLKNLPADLMNESNTGSQFQEPEQPMQ 304 E L+ + A+P R + P I+ ++L L + + + + E + Sbjct: 265 CPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVV 324 Query: 305 SLDTIMQI 312 +Q+ Sbjct: 325 KRMQSLQL 332 >4EUT-A nrPDB Length = 396 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G R K T +L A+K + + RE + L H NIV+ + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 86 L--TPTHLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY + NA E E + ++ G+++ I HR Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 136 Query: 141 DLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR------- 191 ++K N + + K+ DFG ++ Q S GT Y+ P++ R Sbjct: 137 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 196 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Q+ G D+WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 197 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5UNP-A nrPDB Length = 369 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 118/326 (36%), Gaps = 70/326 (21%) Query: 20 DRYDFVKDIGSGNFGVARLMR-DKLTKELVAVKYIERGDKIDENVQREIINHRSLR---- 74 +RY+ V +G G FG + VA+K I+ +K E + EI + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDP 93 Query: 75 -HPNI-VRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVS 130 + N+ V+ + H+ I E G ++ + + + + R QL V Sbjct: 94 DNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVK 152 Query: 131 YCHSMQICHRDLKLENTLLDGSP-----------------APRLKICDFGYSKSSVLHSQ 173 + H ++ H DLK EN L S + +++ DFG + H Sbjct: 153 FLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT--FDHEH 210 Query: 174 PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 + V T Y APEV+L + + DVWS G ++ VG F+ + R++ ++R Sbjct: 211 HSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQ-THDNREHLAMMER 268 Query: 234 ILSVKYSI---------------------------------PDDIRISPEC------CHL 254 IL S P ++ E L Sbjct: 269 ILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDL 328 Query: 255 ISRIFVADPATRISIPEIKTHSWFLK 280 I + +PA R+++ E H +F + Sbjct: 329 IESMLEYEPAKRLTLGEALQHPFFAR 354 >5XVU-A nrPDB Length = 332 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 116/300 (38%), Gaps = 41/300 (13%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + +RY+ +K IG G + D A + ++REI ++L Sbjct: 27 WNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA--IKVLKPVKKKKIKREIKILQNLNG 84 Query: 76 -PNIVRFKEVILTP--THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 PNI++ +++ P ++I EY + + +F++ + R++ Q+L + YC Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALDYC 141 Query: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 HS I HRD+K N ++D ++++ +G ++ + V + Y PE+L+ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENR-QIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDL 200 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS---------------- 236 + D+WS G L M+ PF + D I ++L Sbjct: 201 QLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLK 260 Query: 237 -------VKYSIPDDIRI---------SPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 +Y E LI ++ + D A RI+ E H +F + Sbjct: 261 PHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >3I81-A nrPDB Length = 315 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 54/290 (18%), Positives = 110/290 (37%), Gaps = 31/290 (10%) Query: 6 VTTGPLDMP--IMHDSDRYDFVKDIGSGNFGVARLMRDK-----LTKELVAVKYIERGDK 58 V+ + +P ++ +++G G+FG+ K + VA+K + Sbjct: 2 VSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAAS 61 Query: 59 IDEN--VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG----- 111 + E E + ++VR V+ +IME + G+L + + Sbjct: 62 MRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMEN 121 Query: 112 -----RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK 166 S + ++ G++Y ++ + HRDL N ++ +KI DFG ++ Sbjct: 122 NPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFT--VKIGDFGMTR 179 Query: 167 ---SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPE 222 + + + + +++PE L + +DVWS GV L+ + P++ Sbjct: 180 DIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTY-SDVWSFGVVLWEIATLAEQPYQGLS 238 Query: 223 EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + R ++ L K D+ L+ + +P R S EI Sbjct: 239 NEQVLRFVMEGGLLDKPDNCPDMLF-----ELMRMCWQYNPKMRPSFLEI 283 >3UIU-A nrPDB Length = 306 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 111/287 (38%), Gaps = 51/287 (17%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 + ++ IGSG FG + ++ + ++ ++ +E +RE+ L H NIV Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYN---NEKAEREVKALAKLDHVNIVH 69 Query: 81 FKEVILTPTH-----------------------------LAIIMEYASGGELYERICNAG 111 + + L I ME+ G L + I Sbjct: 70 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 129 Query: 112 --RFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 + + A F+Q+ GV Y HS ++ HRDLK N L + ++KI DFG S Sbjct: 130 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK--QVKIGDFGLVTSLK 187 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYR 228 + + GT Y++PE + Q+Y GK D+++ G+ L +L V FE + D R Sbjct: 188 NDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLR 246 Query: 229 K-TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 I I K L+ ++ P R + EI Sbjct: 247 DGIISDIFDKKE------------KTLLQKLLSKKPEDRPNTSEILR 281 >5TOS-A nrPDB Length = 395 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 112/305 (36%), Gaps = 37/305 (12%) Query: 21 RYDFVKDIGSGNFGVARLM---------RDKLTKELVAVKYIE-RGDKIDENVQREIINH 70 + IG G FG T ++AVK + G + EI Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 Query: 71 RSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLL 126 L HPN+V+ L H ++ E+ G L + G Sbjct: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 Query: 127 SGVSYCHS--MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV---GTP 181 G+++ HS +++ +RD+K N LLD K+ DFG ++ + + GT Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE---------PRDYRKTIQ 232 Y APE + + + +DV+S GV L +L G + R Y + + Sbjct: 244 GYAAPEYMSSGHLNAR-SDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Query: 233 RILSVKYSIPDDIRISPECCHLIS---RIFVADPATRISIPEIKTHSWFLKNLPADLMNE 289 ++L + + D + E + S + +P +R ++ ++ L+ L +L Sbjct: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA---LQQLQDNLGKP 359 Query: 290 SNTGS 294 S T Sbjct: 360 SQTNP 364 >4M7I-A nrPDB Length = 299 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 107/288 (37%), Gaps = 40/288 (13%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHPNI 78 ++ ++ +G G FGV ++K+ A+K I + E V RE+ L HP I Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 65 Query: 79 VRFKEVILTPT------------HLAIIMEYASGGELYERICNAGRFSEDEA---RFFFQ 123 VR+ L +L I M+ L + + E E F Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ---------- 173 Q+ V + HS + HRDLK N +K+ DFG + + Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 174 ---PKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT 230 VGT Y++PE + Y K D++S G+ L+ +L YPF E +T Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSYSHK-VDIFSLGLILFELL---YPFSTQMERV---RT 236 Query: 231 IQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 + + ++K+ + E + + P R I ++ F Sbjct: 237 LTDVRNLKFPPLFTQKYPCEYVM-VQDMLSPSPMERPEAINIIENAVF 283 >4YFF-A nrPDB Length = 311 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 65/260 (25%), Positives = 103/260 (39%), Gaps = 18/260 (6%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPNI 78 +F + IGSG+FG R + ++VA+K + RE+ L HP + Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 79 VRFKEVIL-TPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ-QLLSGVSYCHS-- 134 ++F L P+ AI+ +Y SGG L+ + R + +++ + G+ Y H+ Sbjct: 103 IQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLT 162 Query: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQ 192 I HRDL N LL + DFG S+ S+ G ++APEV + Sbjct: 163 QPIIHRDLNSHNILLYEDGHAVV--ADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQC 220 Query: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 ADV+S + L+ +L G PF + P I Sbjct: 221 TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYH----HIRPPIGYSIPKPIS 276 Query: 253 HLISRIFVADPATRISIPEI 272 L+ R + A P R E+ Sbjct: 277 SLLIRGWNACPEGRPEFSEV 296 >6O8B-A nrPDB Length = 665 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 61/229 (26%), Positives = 97/229 (42%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G R K T +L A+K + + RE + L H NIV+ + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 82 Query: 86 L--TPTHLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY + NA E E + ++ G+++ I HR Sbjct: 83 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 142 Query: 141 DLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR------- 191 ++K N + + K+ DFG ++ Q GT Y+ P++ R Sbjct: 143 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDH 202 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Q+ G D+WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 203 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >6NT9-A nrPDB Length = 742 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 16/229 (6%) Query: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVI 85 +G G R K T +L A+K + + RE + L H NIV+ + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 Query: 86 L--TPTHLAIIMEYASGGELYERI---CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 T H +IME+ G LY + NA E E + ++ G+++ I HR Sbjct: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 Query: 141 DLKLENTL--LDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR------- 191 ++K N + + K+ DFG ++ Q S GT Y+ P++ R Sbjct: 135 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 194 Query: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Q+ G D+WS GVT Y G+ PF E PR ++ + +I++ K S Sbjct: 195 QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >3MDY-A nrPDB Length = 337 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 118/296 (39%), Gaps = 47/296 (15%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNI 78 + + VK IG G +G + + + E VAVK ++ + EI +RH NI Sbjct: 36 AKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENI 93 Query: 79 VRFKEVILTP----THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH- 133 + F + T L +I +Y G LY+ + + +SG+ + H Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKS-TTLDAKSMLKLAYSSVSGLCHLHT 152 Query: 134 -------SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-----PKSTVGTP 181 I HRDLK +N L+ + I D G + + + P + VGT Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 182 AYIAPEV----LLRQEYDGKI-ADVWSCGVTLYVMLVG----------AYPFED----PE 222 Y+ PEV L R + I AD++S G+ L+ + P+ D Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 270 Query: 223 EPRDYRKTIQRILSVKYSIPDDIRISPECC----HLISRIFVADPATRISIPEIKT 274 D R+ + I ++ S P+ S EC L++ + +PA+R++ +K Sbjct: 271 SYEDMREIVC-IKKLRPSFPNRWS-SDECLRQMGKLMTECWAHNPASRLTALRVKK 324 >6CTH-A nrPDB Length = 309 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 105/276 (38%), Gaps = 22/276 (7%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKID-ENVQREIINHRSLRHP 76 + ++ +G G FG + + +AVK + R K + E+ LRH Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHK 72 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF-FFQQLLSGVSYCHSM 135 N+V+ L ++ E+ + G L I E R+ + L S + Y H Sbjct: 73 NLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 136 Q---ICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLL 190 + HRD+K N +LD S K+ DFG ++ + GT Y+APE L Sbjct: 133 GDHCVLHRDIKTSNIMLDSS--FNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS 190 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI---------QRILSVKYSI 241 + K +DV+S GV + G E E + + +RIL + Sbjct: 191 SGK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRK 249 Query: 242 PDDIRISPECCHL-ISRIFVADPAT--RISIPEIKT 274 + L + ++ A P+ R SI ++ Sbjct: 250 LGMAFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >3AOX-A nrPDB Length = 344 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 54/290 (18%), Positives = 103/290 (35%), Gaps = 26/290 (8%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMR-----DKLTKELVAVKYIER--G 56 A T+ D+ ++ +G G FG + + + VAVK + Sbjct: 32 AGKTSSISDLK-EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCS 90 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR---- 112 ++ + + E + H NIVR V L I++E +GG+L + Sbjct: 91 EQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQ 150 Query: 113 ---FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRL-KICDFGYSK-- 166 + + + + G Y HRD+ N LL R+ KI DFG ++ Sbjct: 151 PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 210 Query: 167 -SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEP 224 + + + + ++ PE + + K D WS GV L+ + G P+ Sbjct: 211 YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK-TDTWSFGVLLWEIFSLGYMPYPSKSN- 268 Query: 225 RDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 ++ ++ + S P ++++ + P R + I Sbjct: 269 ---QEVLEFVTSGGRMDPPK-NCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >5VD3-A nrPDB Length = 311 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 103/264 (39%), Gaps = 17/264 (6%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGDKIDENVQREIINHRSL-RHPN 77 + + +G G++G +R K L AVK RG K E+ +H + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVSYCHSMQ 136 VR ++ L + E G L + G E + + + L +++ HS Sbjct: 119 CVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQG 177 Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 + H D+K N L P R K+ DFG + G P Y+APE+L G Sbjct: 178 LVHLDVKPANIFLG--PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YG 233 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 ADV+S G+T+ + P +++ Q L +++ +S E ++ Sbjct: 234 TAADVFSLGLTILEVACNMEL---PHGGEGWQQLRQGYLPPEFT----AGLSSELRSVLV 286 Query: 257 RIFVADPATRISIPEIKTHSWFLK 280 + DP R + + + Sbjct: 287 MMLEPDPKLRATAEALLALPVLRQ 310 >2RIO-A nrPDB Length = 434 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 112/285 (39%), Gaps = 38/285 (13%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEV 84 K +G G+ G + + VAVK + + EI HPN++R+ Sbjct: 21 KILGYGSSGTV-VFQGSFQGRPVAVKRMLIDFC--DIALMEIKLLTESDDHPNVIRYYCS 77 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEAR-------FFFQQLLSGVSYCHSMQI 137 T L I +E + L + + + E+ +Q+ SGV++ HS++I Sbjct: 78 ETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKI 136 Query: 138 CHRDLKLENTLLDGS-----------PAPRLKICDFGYSKSSVLH-----SQPKSTVGTP 181 HRDLK +N L+ S R+ I DFG K + + GT Sbjct: 137 IHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTS 196 Query: 182 AYIAPEV------LLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRI 234 + APE+ L + + D++S G Y +L G +PF D I+ I Sbjct: 197 GWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRES--NIIRGI 254 Query: 235 LSV-KYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 S+ + D + E LIS++ DP R + ++ H F Sbjct: 255 FSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >4FL3-A nrPDB Length = 635 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 92/257 (35%), Gaps = 19/257 (7%) Query: 26 KDIGSGNFGVARLMRDK-----LTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 K++GSGNFG + + T + +K + + + E + L +P IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 + + + ++ME A G L + + + Q+ G+ Y HR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLRQEYDG 196 DL N LL KI DFG SK+ + APE + ++ Sbjct: 494 DLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 Query: 197 KIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K +DVWS GV ++ G P+ + + +L + E L+ Sbjct: 552 K-SDVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAGCPREMYDLM 605 Query: 256 SRIFVADPATRISIPEI 272 + + D R + Sbjct: 606 NLCWTYDVENRPGFAAV 622 >5U6C-A nrPDB Length = 315 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 97/276 (35%), Gaps = 29/276 (10%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKL---TKELVAVKYIE---RGDKIDENVQREII 68 ++ D + K +G G FG K T VAVK ++ + E E Sbjct: 31 VVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAA 90 Query: 69 NHRSLRHPNIVRFKEVILTP-----THLAIIMEYASGGELYERIC------NAGRFSEDE 117 + HPN++R V + +I+ + G+L+ + Sbjct: 91 CMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQT 150 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS---SVLHSQP 174 F + G+ Y + HRDL N +L + + DFG SK + Q Sbjct: 151 LLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMT--VCVADFGLSKKIYSGDYYRQG 208 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQR 233 + +IA E L + Y K +DVW+ GVT++ + G P+ + Y + Sbjct: 209 RIAKMPVKWIAIESLADRVYTSK-SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLH- 266 Query: 234 ILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 + + E ++ + DP R + Sbjct: 267 ----GHRLKQPEDCLDELYEIMYSCWRTDPLDRPTF 298 >3ZZW-A nrPDB Length = 289 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 101/277 (36%), Gaps = 35/277 (12%) Query: 23 DFVKDIGSGNFGVARLMR--DKLTKEL---VAVKYIERGDK--IDENVQREIINHRSLRH 75 F++++G FG E VA+K ++ + + E + E + L+H Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----------------FSEDEAR 119 PN+V V+ L++I Y S G+L+E + + Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 120 FFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK---S 176 Q+ +G+ Y S + H+DL N L+ +KI D G + K + Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDK--LNVKISDLGLFREVYAADYYKLLGN 189 Query: 177 TVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRIL 235 ++ ++APE ++ ++ +D+WS GV L+ G P+ R + Sbjct: 190 SLLPIRWMAPEAIMYGKFSI-DSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 +P L+ + P+ R +I Sbjct: 249 -----LPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5VC6-A nrPDB Length = 289 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 119/296 (40%), Gaps = 37/296 (12%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GDKIDENVQR 65 G M + ++ + ++ IGSG FG +L + A+K ++ G ++N R Sbjct: 1 GAGSMKSRYTTE-FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALR 59 Query: 66 EIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR----FSEDEARF 120 E+ H L +H ++VR+ H+ I EY +GG L + I R F E E + Sbjct: 60 EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRL-----------------KICDFG 163 Q+ G+ Y HSM + H D+K N + + P KI D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 164 YSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 + S P+ G ++A EVL AD+++ +T+ V GA P P Sbjct: 180 HVTRI---SSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPL--PRN 233 Query: 224 PRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 + + Q L IP +S E L+ + DP R S + HS L Sbjct: 234 GDQWHEIRQGRL---PRIPQ--VLSQEFTELLKVMIHPDPERRPSAMALVKHSVLL 284 >5C26-A nrPDB Length = 299 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 92/257 (35%), Gaps = 19/257 (7%) Query: 26 KDIGSGNFGVARLMRDK-----LTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVR 80 K++GSGNFG + + T + +K + + + E + L +P IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 + + + ++ME A G L + + + Q+ G+ Y HR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVG----TPAYIAPEVLLRQEYDG 196 DL N LL KI DFG SK+ + APE + ++ Sbjct: 152 DLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 209 Query: 197 KIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 K +DVWS GV ++ G P+ + + +L + E L+ Sbjct: 210 K-SDVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAGCPREMYDLM 263 Query: 256 SRIFVADPATRISIPEI 272 + + D R + Sbjct: 264 NLCWTYDVENRPGFAAV 280 >5LPZ-A nrPDB Length = 332 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 97/274 (35%), Gaps = 26/274 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKY-IERGDKIDENVQREIINHRSLRHPNIVR 80 + IGSG FG K VA+K I + D E+ ++H N+V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLLSGVSYCHSM- 135 ++ E+ G L + + + + + R G+++ H Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 136 --QICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLL 190 I HRD+K N LLD + R+ DFG ++ + H + GTP Y+ PE Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARV--SDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFE----DPEEPRDYRKTIQRILSVKYSIPDDIR 246 K DV+S GV L +L G P + + K ++ P+ ++ Sbjct: 196 SFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMK 254 Query: 247 ISPEC-CHLISR------IFVADPATRISIPEIK 273 P L+ R ++ ++ Sbjct: 255 EDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >1PY5-A nrPDB Length = 326 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 113/290 (38%), Gaps = 45/290 (15%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 + IG G FG R K E VAVK ++ + EI LRH NI+ F Sbjct: 33 LQESIGKGRFGEV--WRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 84 VILTPT----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH------ 133 L ++ +Y G L++ + N + + SG+++ H Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYL-NRYTVTVEGMIKLALSTASGLAHLHMEIVGT 149 Query: 134 --SMQICHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVLHSQPKSTVGTPAYIAP 186 I HRDLK +N L+ + I D G + + + P VGT Y+AP Sbjct: 150 QGKPAIAHRDLKSKNILVKKNGT--CCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 187 EVL-----LRQEYDGKIADVWSCGVTLYVMLVG----------AYPFEDPEEPRDYRKTI 231 EVL ++ K AD+++ G+ + + P+ D + + Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEM 267 Query: 232 QRIL---SVKYSIPDDIRISPECC----HLISRIFVADPATRISIPEIKT 274 ++++ ++ +IP+ + S E ++ + A+ A R++ IK Sbjct: 268 RKVVCEQKLRPNIPNRWQ-SCEALRVMAKIMRECWYANGAARLTALRIKK 316 >6J5U-C nrPDB Length = 426 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 100/286 (34%), Gaps = 36/286 (12%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLT---------KELVAVKYIE-RGDKIDENVQREII 68 + + +G G FG T +VAVK ++ G + + E+ Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVN 142 Query: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLL 126 L HPN+V + ++ E+ G L + G + Sbjct: 143 YLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAA 202 Query: 127 SGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTP 181 G+++ H + + +RD K N LLD K+ DFG +K+ +GT Sbjct: 203 KGLTFLHEAKSQVIYRDFKAANILLDAD--FNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY------------RK 229 Y APE + K +DV+S GV L ++ G ++ +Y ++ Sbjct: 261 GYAAPEYVATGRLTAK-SDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKR 319 Query: 230 TIQRILSVKY--SIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 + RI+ K P + +L + D R + E+ Sbjct: 320 KLFRIMDTKLGGQYPQKGAFT--AANLALQCLNPDAKLRPKMSEVL 363 >5LPV-A nrPDB Length = 296 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 97/274 (35%), Gaps = 26/274 (9%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKY-IERGDKIDENVQREIINHRSLRHPNIVR 80 + IGSG FG K VA+K I + D E+ ++H N+V Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVP 77 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLLSGVSYCHSM- 135 ++ E+ G L + + + + + R G+++ H Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 136 --QICHRDLKLENTLLDGSPAPRLKICDFGYSK---SSVLHSQPKSTVGTPAYIAPEVLL 190 I HRD+K N LLD + R+ DFG ++ + H + GTP Y+ PE Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARV--SDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFE----DPEEPRDYRKTIQRILSVKYSIPDDIR 246 K DV+S GV L +L G P + + K ++ P+ ++ Sbjct: 196 SFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMK 254 Query: 247 ISPEC-CHLISR------IFVADPATRISIPEIK 273 P L+ R ++ ++ Sbjct: 255 EDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5AR8-A nrPDB Length = 326 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 103/269 (38%), Gaps = 22/269 (8%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYI----ERGDKIDENVQREIINHRSLRHPNIVR 80 ++ + G G R + VAVK++ D ++V RE R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFS---EDEARFFFQQLLSGVSYCHSMQ- 136 + P L I+ EY G L E + + ++ GV+Y H+M Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 137 -ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV------GTPAYIAPEVL 189 + H DLK +N LLD +KI DFG SK ++ + GT Y+ PE Sbjct: 157 PLLHHDLKTQNILLDNE--FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 190 L--RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI---QRILSVKYSIPDD 244 ++ D++S V + +L PFED P ++ R + + S+P D Sbjct: 215 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYD 274 Query: 245 IRISPECCHLISRIFVADPATRISIPEIK 273 I LI + +P R S + Sbjct: 275 IPHRARMISLIESGWAQNPDERPSFLKCL 303 >5CEK-A nrPDB Length = 263 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 74/248 (29%), Positives = 113/248 (45%), Gaps = 19/248 (7%) Query: 36 ARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPNIVRFKEVILTPTHLAII 94 T + K D+ I + L H NI EVIL T + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDK-----IRPYIQLPSHSNITGIVEVILGETKAYVF 79 Query: 95 MEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPA 154 E G+++ + + R E+EA F+Q++S V++CH I DLKL + Sbjct: 80 FE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER 138 Query: 155 PRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVLL-RQEYDGKIADVWSCGVTLYV 210 +L++ + ++ + + G PAY++PE+L Y GK ADVWS GV LY Sbjct: 139 TQLRLES--LEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 196 Query: 211 MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 +LVG YPF D + + K I ++ IP+ ISP+ LI + +P+ R++ P Sbjct: 197 LLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAP 250 Query: 271 EIKTHSWF 278 EI H WF Sbjct: 251 EILLHPWF 258 >6DC0-A nrPDB Length = 292 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 74/248 (29%), Positives = 113/248 (45%), Gaps = 19/248 (7%) Query: 36 ARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL-RHPNIVRFKEVILTPTHLAII 94 T + K D+ I + L H NI EVIL T + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDK-----IRPYIQLPSHSNITGIVEVILGETKAYVF 76 Query: 95 MEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPA 154 E G+++ + + R E+EA F+Q++S V++CH I DLKL + Sbjct: 77 FE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEER 135 Query: 155 PRLKICDFGYSKSSVLHSQPKSTV---GTPAYIAPEVLL-RQEYDGKIADVWSCGVTLYV 210 +L++ + ++ + + G PAY++PE+L Y GK ADVWS GV LY Sbjct: 136 TQLRLES--LEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYT 193 Query: 211 MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIP 270 +LVG YPF D + + K I ++ IP+ ISP+ LI + +P+ R++ P Sbjct: 194 LLVGRYPFHDSDPSALFSK----IRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAP 247 Query: 271 EIKTHSWF 278 EI H WF Sbjct: 248 EILLHPWF 255 >6HV0-A nrPDB Length = 416 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 121/321 (37%), Gaps = 21/321 (6%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVI 85 +G G G + R VAVK I + RE+ R HPN++R+ Sbjct: 15 VLGHGAEGTI-VYRGMFDNRDVAVKRI--LPECFSFADREVQLLRESDEHPNVIRYFCTE 71 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSED-EARFFFQQLLSGVSYCHSMQICHRDLKL 144 I +E + L E + E QQ SG+++ HS+ I HRDLK Sbjct: 72 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKP 130 Query: 145 ENTLLDG-SPAPRLK--ICDFGYSKSSVLH----SQPKSTVGTPAYIAPEVLLR--QEYD 195 N L+ + ++K I DFG K + S+ GT +IAPE+L +E Sbjct: 131 HNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENP 190 Query: 196 GKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 D++S G Y ++ G++PF + + + S+ + + L Sbjct: 191 TYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLGACSLD-CLHPEKHEDVIAREL 247 Query: 255 ISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIIS 314 I ++ DP R S + H +F +L L + + E E + ++ Sbjct: 248 IEKMIAMDPQKRPSAKHVLKHPFFW-SLEKQLQFFQDVSDRI-EKESLDGPIVKQLERGG 305 Query: 315 EATIPAVRNRCLDDFMTDNLD 335 A + + + +L Sbjct: 306 RAVVKMDWRENITVPLQTDLR 326 >4PL5-B nrPDB Length = 435 Score = 176 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 65/264 (24%), Positives = 102/264 (38%), Gaps = 19/264 (7%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVI 85 +G G G + + VAVK I + RE+ R HPN++R+ Sbjct: 34 VLGHGAEGTI-VYKGMFDNRDVAVKRI--LPECFSFADREVQLLRESDEHPNVIRYFCTE 90 Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSED-EARFFFQQLLSGVSYCHSMQICHRDLKL 144 I +E + L E + E Q SG+++ HS+ I HRDLK Sbjct: 91 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKP 149 Query: 145 ENTLLDG-SPAPRLK--ICDFGYSKSSVLH----SQPKSTVGTPAYIAPEVLLR--QEYD 195 N LL + R+K I DFG K + S+ GT +IAPE+L ++ Sbjct: 150 HNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNP 209 Query: 196 GKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 D++S G Y ++ G +PF + + + ++ D L Sbjct: 210 TYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLD-CFHSDKHEDVIAREL 266 Query: 255 ISRIFVADPATRISIPEIKTHSWF 278 I ++ DP R S + H +F Sbjct: 267 IEKMIAMDPQQRPSAKHVLKHPFF 290 >2X7G-A nrPDB Length = 389 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 72/362 (19%), Positives = 112/362 (30%), Gaps = 106/362 (29%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH--- 75 + RY ++ +G G+F L D K VA+K ++ E EI + +R Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDP 89 Query: 76 --PN---IVRFKEVI----LTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQL 125 PN +V+ + + H+ ++ E L I N + +Q+ Sbjct: 90 SDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQV 149 Query: 126 LSGVSYCHSM-QICHRDLKLENTLLDGSPAP----------------------------- 155 L G+ Y HS +I H D+K EN L+ A Sbjct: 150 LQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPA 209 Query: 156 ----------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIA 199 R+KI D G + +H + T Y + EVL+ Y A Sbjct: 210 ADLLVNPLDPRNADKIRVKIADLGNA--CWVHKHFTEDIQTRQYRSIEVLIGAGYSTP-A 266 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKT---IQRILSVKYSIPDDIRIS-------- 248 D+WS + + G Y FE P DY + I I+ + SIP +S Sbjct: 267 DIWSTACMAFELATGDYLFE-PHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 249 --------------------------------PECCHLISRIFVADPATRISIPEIKTHS 276 + + + P R S E H Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 277 WF 278 W Sbjct: 386 WL 387 >3LMG-A nrPDB Length = 344 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 116/295 (39%), Gaps = 23/295 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKE----LVAVKYI--ERGDKIDENVQREIINHRSLR 74 +K +GSG FG E V +K I + G + + V ++ SL Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD 91 Query: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSGVSYCH 133 H +IVR + + L ++ +Y G L + + + G + Q+ G+ Y Sbjct: 92 HAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 150 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ--PKSTVGTP-AYIAPEVLL 190 + HR+L N LL ++++ DFG + + S TP ++A E + Sbjct: 151 EHGMVHRNLAARNVLLKS--PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH 208 Query: 191 RQEYDGKIADVWSCGVTLYV-MLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISP 249 +Y + +DVWS GVT++ M GA P+ + +L + + Sbjct: 209 FGKYTHQ-SDVWSYGVTVWELMTFGAEPYAGLRLAE-----VPDLLEKGERLAQPQICTI 262 Query: 250 ECCHLISRIFVADPATRISIPEIKTHSW--FLKNLPADLMNESNTGSQFQEPEQP 302 + ++ + ++ D R + E + + ++ P L+ + +G +P Sbjct: 263 DVYMVMVKCWMIDENIRPTFKE-LANEFTRMARDPPRYLVIKRESGPGIAPGPEP 316 >4IAN-A nrPDB Length = 358 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 70/327 (21%), Positives = 119/327 (36%), Gaps = 68/327 (20%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLT-KELVAVKYIERGDKIDENVQREIINHRSLRHP-- 76 RY+ G G F RD + VAVK I + + + +E+ + L Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADP 89 Query: 77 ----NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR---FSEDEARFFFQQLLSGV 129 + +R HL ++ E S L E + G+ R + QQL + Sbjct: 90 DDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLAL 148 Query: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 I H D+K +N L++ S LK+CDFG + S V + + + Y APE++ Sbjct: 149 KLLKRCNILHADIKPDNILVNESKTI-LKLCDFGSA-SHVADNDITPYLVSRFYRAPEII 206 Query: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPE--------------------------- 222 + + YD D+WS G TLY + G F Sbjct: 207 IGKSYD-YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKD 265 Query: 223 --------------EPRDYRKTIQRILSVKYS------------IPDDIRISP-ECCHLI 255 + R+ + + ++ + +P+D R + L+ Sbjct: 266 QHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLL 325 Query: 256 SRIFVADPATRISIPEIKTHSWFLKNL 282 +I + DPA RISI + H++ + + Sbjct: 326 DQILMLDPAKRISINQALQHAFIQEKI 352 >4WUA-A nrPDB Length = 401 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 71/364 (19%), Positives = 117/364 (32%), Gaps = 108/364 (29%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH--P 76 + RY ++ +G G+F L D K+ VA+K ++ + E EI +S+R+ P Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDP 99 Query: 77 N------IVRFKEVIL----TPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQL 125 N +V+ + TH+ ++ E L I N + QQ+ Sbjct: 100 NDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQV 159 Query: 126 LSGVSYCHSM-QICHRDLKLENTLLDGSPAP----------------------------- 155 L G+ Y H+ +I H D+K EN LL + Sbjct: 160 LQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPA 219 Query: 156 ------------------RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK 197 ++KI D G + +H + T Y + EVL+ Y+ Sbjct: 220 TAGNFLVNPLEPKNAEKLKVKIADLGNA--CWVHKHFTEDIQTRQYRSLEVLIGSGYNTP 277 Query: 198 IADVWSCGVTLYVMLVGAYPFEDPEEPRDY---------------RKTIQRILSVKYSIP 242 AD+WS + + G Y FE P +Y + + I++ KYS Sbjct: 278 -ADIWSTACMAFELATGDYLFE-PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKE 335 Query: 243 ------------------------DDIRISPE----CCHLISRIFVADPATRISIPEIKT 274 + S E + + P R + E Sbjct: 336 FFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR 395 Query: 275 HSWF 278 H W Sbjct: 396 HPWL 399 >5XD6-A nrPDB Length = 305 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 87/234 (37%), Gaps = 20/234 (8%) Query: 3 RAPVTTGPLDMPIMHD-SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDE 61 P++ + + D +D Y IG G++G K + + A+K ++ + D+ Sbjct: 4 HQPISVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQ 62 Query: 62 NVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--------- 112 ++ LR N+V + + EYA G L++ + Sbjct: 63 EFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPV 122 Query: 113 FSEDEARFFFQQLLSGVSYCHSM---QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 S + G+ Y H + HRD+K N LL KI DF S + Sbjct: 123 LSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVA--KIADFDLSNQAP 180 Query: 170 LHS---QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFED 220 + +GT Y APE + K +DV+S GV L +L G P + Sbjct: 181 DMAARLHSTRVLGTFGYHAPEYAMTGTLSTK-SDVYSFGVVLLELLTGRKPVDH 233 >3LLT-A nrPDB Length = 360 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 69/327 (21%), Positives = 120/327 (36%), Gaps = 74/327 (22%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-----HP 76 + ++ +G G FG L + K+ AVK + K + + E + ++ + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERIC--NAGRFSEDEARFFFQQLLSGVSYCHS 134 NIV++ + H+ +I E G LYE I N F ++ + + ++L ++Y Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRK 155 Query: 135 MQICHRDLKLENTLLDG-----------------------SPAPRLKICDFGYSKSSVLH 171 M + H DLK EN LLD + + +K+ DFG + + Sbjct: 156 MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDY 215 Query: 172 SQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE-------- 223 S + T Y APEV+L +D +D+WS G L + G+ F E Sbjct: 216 --HGSIINTRQYRAPEVILNLGWDV-SSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMME 272 Query: 224 ------PRDYRKTIQRILSVKYSIPDDIRIS--------------------------PEC 251 P++ + KY D+++++ Sbjct: 273 SIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHELF 332 Query: 252 CHLISRIFVADPATRISIPEIKTHSWF 278 C + I DP R S E+ H + Sbjct: 333 CDFLYSILQIDPTLRPSPAELLKHKFL 359 >5L2Q-C nrPDB Length = 320 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 116/280 (41%), Gaps = 47/280 (16%) Query: 37 RLMRDKLTKELVAVKYIERGDKIDENVQ-REIINHRSLRH------------PNIVRFKE 83 L R T + +K + ++ D+ ++ +E + L H +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 84 VILT------------------PTHLAIIME-YASGG---------ELYERICNAGRFSE 115 + + ++++ + L + R SE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 116 DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP- 174 E F ++ V H I HRDLKL N +L+ R+ I +F K V Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN-KRTHRITITNFCLGKHLVSEGDLL 211 Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 K G+PAYI+P+VL + Y GK +D+W+ GV L+ ML G +PF D ++ ++I Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS----IPQELFRKI 267 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 + +Y+IP+D R+S LI ++ V DP R++ ++ Sbjct: 268 KAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >2JD5-A nrPDB Length = 373 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 114/324 (35%), Gaps = 70/324 (21%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP---- 76 RY V+ +G G+F L +D + VA+K + E + EI + + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 77 -------NIVRFKEVILTPT----HLAIIMEYASGGELYERICN--AGRFSEDEARFFFQ 123 +I++ + H+ ++ E G L I + + Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLIYVKQISK 138 Query: 124 QLLSGVSYCHSM-QICHRDLKLENTLLDGSPAP----RLKICDFGYSKSSVLHSQPKSTV 178 QLL G+ Y H I H D+K EN L++ +P ++KI D G + +++ Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA--CWYDEHYTNSI 196 Query: 179 GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPR------------- 225 T Y +PEVLL + G AD+WS ++ ++ G + FE E Sbjct: 197 QTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIE 255 Query: 226 --------------------DYRKTIQRILSVKYSIPDDIRISPECC----------HLI 255 + R ++ I +K+ P + ++ + + Sbjct: 256 LLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKF-WPLEDVLTEKYKFSKDEAKEISDFL 314 Query: 256 SRIFVADPATRISIPEIKTHSWFL 279 S + DP R + H W Sbjct: 315 SPMLQLDPRKRADAGGLVNHPWLK 338 >2Y4I-B nrPDB Length = 319 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 120/297 (40%), Gaps = 31/297 (10%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGDKIDENVQREIINHR 71 ++ + + IG G FG R VA++ I + + +RE++ +R Sbjct: 28 WDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYR 84 Query: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG-RFSEDEARFFFQQLLSGVS 130 RH N+V F ++P HLAII G LY + +A ++ R Q+++ G+ Sbjct: 85 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 144 Query: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGY------SKSSVLHSQPKSTVGTPAYI 184 Y H+ I H+DLK +N D ++ I DFG ++ + + G ++ Sbjct: 145 YLHAKGILHKDLKSKNVFYDN---GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 201 Query: 185 APEVLLRQEYDG--------KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILS 236 APE++ + D K +DV++ G Y + +PF+ I ++ + Sbjct: 202 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPA----EAIIWQMGT 257 Query: 237 VKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTG 293 I + E ++ + + R + ++ L+ LP S+ G Sbjct: 258 GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD---MLEKLPKRNRRLSHPG 311 >3UIM-A nrPDB Length = 326 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 108/278 (38%), Gaps = 28/278 (10%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGDKIDENVQREIINHRSLRHP 76 SD + +G G FG R LVAVK ++ R + Q E+ H Sbjct: 29 SDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHR 87 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGE----LYERICNAGRFSEDEARFFFQQLLSGVSYC 132 N++R + +TPT ++ Y + G L ER + + + G++Y Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 133 HSM---QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPE 187 H +I HRD+K N LLD + DFG +K +T GT +IAPE Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVV--GDFGLAKLMDYKDTHVTTAVRGTIGHIAPE 205 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPF-------EDPEEPRDYRKTIQRILSVKYS 240 L + K DV+ GV L ++ G F +D D+ K + + ++ Sbjct: 206 YLSTGKSSEK-TDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEAL 264 Query: 241 IPDDIR---ISPECCHLIS---RIFVADPATRISIPEI 272 + D++ E LI + P R + E+ Sbjct: 265 VDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEV 302 >4LFI-A nrPDB Length = 374 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 113/336 (33%), Gaps = 77/336 (22%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAV------------------------ 50 ++ Y+ +G G + +K + + Sbjct: 35 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 94 Query: 51 KY----IERGDKIDENVQREIINHRSLR----------HPNIVRFKEVILTP--THLAII 94 K + Q+E + +R H NI+ ++I P A++ Sbjct: 95 KVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 153 Query: 95 MEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPA 154 EY + + ++ E RF+ +LL + YCHSM I HRD+K N ++D Sbjct: 154 FEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKN 209 Query: 155 PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVG 214 +L++ D+G ++ ++ + V + + PE+L+ D+WS G L M+ Sbjct: 210 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 269 Query: 215 AYPFEDPEEPRDYRKTIQRILSV----KYSIPDDIRISPEC------------------- 251 PF D I ++L KY + +I + E Sbjct: 270 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 329 Query: 252 ---------CHLISRIFVADPATRISIPEIKTHSWF 278 LI + D R++ E H WF Sbjct: 330 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >2PMN-X nrPDB Length = 348 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 115/310 (37%), Gaps = 49/310 (15%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN----------------- 62 + Y ++ + G F L + A+K E+ + Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 63 -VQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGEL-----YERICNAGR---F 113 + E+ +++ + + +I + II EY + Y + + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFI 148 Query: 114 SEDEARFFFQQLLSGVSYCH-SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 + + +L+ SY H ICHRD+K N L+D + R+K+ DFG S ++ Sbjct: 149 PIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKN--GRVKLSDFGES-EYMVDK 205 Query: 173 QPKSTVGTPAYIAPEVLLRQE-YDGKIADVWSCGVTLYVMLVGAYPF------------- 218 + K + GT ++ PE + Y+G D+WS G+ LYVM PF Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 219 --EDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHS 276 ++ E P D R L+ K S + +S E + +PA RI+ + H Sbjct: 266 RTKNIEYPLD-RNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHE 324 Query: 277 WFLKNLPADL 286 W DL Sbjct: 325 WLADTNIEDL 334 >2H34-A nrPDB Length = 309 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 99/251 (39%), Gaps = 12/251 (4%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVK----YIERGDKIDENVQREIINHRSLRHPN 77 Y + +G G G D + + +VA+K + +QRE L+ P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 +V + L + M +G +L + G + A +Q+ S + H+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH--SQPKSTVGTPAYIAPEVLLRQEYD 195 HRD+K EN L+ + DFG + ++ +Q +TVGT Y+APE + + Sbjct: 156 THRDVKPENILVSADDFAY--LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-ESHA 212 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 AD+++ LY L G+ P++ + Q I P I +I Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRP---GIPVAFDAVI 269 Query: 256 SRIFVADPATR 266 +R +P R Sbjct: 270 ARGMAKNPEDR 280 >4LQP-A nrPDB Length = 508 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 40/154 (25%), Positives = 71/154 (46%), Gaps = 6/154 (3%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSL----RH 75 + + VK IG G FG RL++ K T ++ A+K + + + ++ + R + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 P +V +L +IME+ GG+L + F+ED RF+ + + + H + Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 HR +K +N L+D +K+ DFG S Sbjct: 222 GFIHRAIKPDNILID--IRGHIKLSDFGLSTGFH 253 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 43/108 (39%), Positives = 52/108 (48%), Gaps = 8/108 (7%) Query: 175 KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI 234 STVGTP YIAPE+ L Q Y G+ D WS G +Y L+G PF YRK + Sbjct: 321 YSTVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN-- 377 Query: 235 LSVKYSIPDDIRISPECCHLISRIFVADPATRI----SIPEIKTHSWF 278 PDDI IS E LI R+ R+ EIK+H +F Sbjct: 378 FEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFF 424 >4M66-A nrPDB Length = 325 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 112/289 (38%), Gaps = 37/289 (12%) Query: 7 TTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQRE 66 TG +P + + ++ +G G FGV + VAVK + + + E Sbjct: 8 PTGASAVP-LVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-----SKKISWE 61 Query: 67 IINHRSLRHPNIVRFKEVILT--PTHL---AIIMEYASGGELYERICNAGRFSEDEARFF 121 + +LR+ N++ V + A++ + G L + Sbjct: 62 VKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRL 121 Query: 122 FQQLLSGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSK-------SSVLHS 172 Q+++ G+ Y HS+ + HRDLK N LLD P K+ DFG S S S Sbjct: 122 LQEVVLGMCYLHSLDPPLLHRDLKPSNILLD--PELHAKLADFGLSTFQGGSQSGSGSGS 179 Query: 173 QPKSTVGTPAYIAPEVLLR-QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 + + GT AY+ PE+L + K +DV+S G+ ++ +L G E D I Sbjct: 180 GSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR-----EAELVDKTSLI 234 Query: 232 QRILSVKYSIPDDIRISP---------ECCHLISRIFVADPATRISIPE 271 + + + S P + P + L+ + + R S + Sbjct: 235 RETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >3REP-A nrPDB Length = 271 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 108/273 (39%), Gaps = 23/273 (8%) Query: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGD---KIDENVQREI 67 ++ D + +F+ + + G L + + + VK ++ D + + E Sbjct: 1 MNKHSGIDFKQLNFLTKLNENHSGE--LWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEEC 58 Query: 68 INHRSLRHPNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDE--ARFFFQ 123 R HPN++ +P H +I + G LY + F D+ A F Sbjct: 59 PRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFAL 118 Query: 124 QLLSGVSYCHSMQ--ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP 181 + G+++ H+++ I L + ++D R+ + D +S Q + P Sbjct: 119 DMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS------FQSPGRMYAP 172 Query: 182 AYIAPEVLLRQEYDG--KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY 239 A++APE L ++ D + AD+WS V L+ ++ PF D K + ++ Sbjct: 173 AWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKV--ALEGLRP 230 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIPEI 272 +IP ISP L+ DPA R I Sbjct: 231 TIPPG--ISPHVSKLMKICMNEDPAKRPKFDMI 261 >3SOC-A nrPDB Length = 322 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 108/304 (35%), Gaps = 45/304 (14%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENV 63 + V G ++ ++ G FG + L E VAVK DK Sbjct: 10 SGVDLGTENLYFQSMP--LQLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQN 65 Query: 64 QREIINHRSLRHPNIVRFKEVILTPT----HLAIIMEYASGGELYERICNAGRFSEDEAR 119 + E+ + ++H NI++F T L +I + G L + + A S +E Sbjct: 66 EYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELC 124 Query: 120 FFFQQLLSGVSYCHS----------MQICHRDLKLENTLLDGSPAPRLKICDFGYS---K 166 + + G++Y H I HRD+K +N LL + I DFG + + Sbjct: 125 HIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC--IADFGLALKFE 182 Query: 167 SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGK----IADVWSCGVTLYVMLVGA------- 215 + VGT Y+APEVL + D+++ G+ L+ + Sbjct: 183 AGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPV 242 Query: 216 ----YPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE------CCHLISRIFVADPAT 265 PFE+ + +Q ++ K P + C I + D Sbjct: 243 DEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEA 302 Query: 266 RISI 269 R+S Sbjct: 303 RLSA 306 >5VDK-A nrPDB Length = 297 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 109/294 (37%), Gaps = 43/294 (14%) Query: 9 GPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKI---DENVQR 65 G +M ++ + + V+ IG G FG +L + A+K + + + Sbjct: 5 GSTNMASRYEKEFLE-VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALH 63 Query: 66 EIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERI----CNAGRFSEDEARF 120 E+ H L HP++VR+ H+ I EY +GG L I + F E + + Sbjct: 64 EVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKD 123 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPR---------------------LKI 159 Q+ G++Y H+ + H D+K N + KI Sbjct: 124 ILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKI 183 Query: 160 CDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 D G++ S ++PK G ++A E+L AD+++ G+T+ V GA Sbjct: 184 GDLGHATSI---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAV-AAGAE--S 237 Query: 220 DPEEPRDYRKTIQRILSVKYSIPD-DIRISPECCHLISRIFVADPATRISIPEI 272 P + K + PD +S L+ + D R S + Sbjct: 238 LPTNGAAWHHIR------KGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >5E8V-A nrPDB Length = 316 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 107/301 (35%), Gaps = 48/301 (15%) Query: 15 IMHDSDRY--DFVKDIGSGNFGVARLMRDKLTK----ELVAVKYIERGDKIDENVQREII 68 MH+++ + +G G F + K E VAVK + +++I Sbjct: 2 HMHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIF 61 Query: 69 NHRSLRHPNIVRFKEVILTPTHL----AIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 + +L+H NI++F T L +I + + G L E + S ++ R Sbjct: 62 SDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSS 120 Query: 125 LLSGVSYCHS---------MQICHRDLKLENTLLDGSPAPRLKICDFGYS-----KSSVL 170 L G+++ HS M I HRDLK N L+ +CDFG S SV Sbjct: 121 LARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLT--CCLCDFGLSLRLDPTLSVD 178 Query: 171 HSQPKSTVGTPAYIAPEVL-----LRQEYDGKIADVWSCGVTLYVMLVG----------A 215 VGT Y+APEVL L K DV+S + L+ M Sbjct: 179 DLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYE 238 Query: 216 YPFED---PEEPRDYRKTIQRILSVKYSIPDDI---RISPECCHLISRIFVADPATRISI 269 PF + + IP + C ++ + DP R++ Sbjct: 239 PPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA 298 Query: 270 P 270 Sbjct: 299 Q 299 >5FQD-C nrPDB Length = 341 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 106/260 (40%), Gaps = 25/260 (9%) Query: 3 RAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDEN 62 R ++G I +Y V+ IGSG+FG L + E VAVK +E Sbjct: 4 RMASSSGSKAEFI--VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKARHPQ 60 Query: 63 VQREIINHRSLRH----PNIVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSED 116 + E ++ L+ P+I R+ + ++M+ S +L+ RF+ Sbjct: 61 LLYESKLYKILQGGVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMK 115 Query: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYS--------KS 167 Q++S + Y H+ HRD+K +N L+ G +L + DFG + + Sbjct: 116 TVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQ 175 Query: 168 SVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY 227 + + + K+ GT Y + L E + D+ S G L + P++ + Sbjct: 176 HIPYREDKNLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKK 234 Query: 228 RKTIQRILSVKYSIPDDIRI 247 +K ++I K S P ++ Sbjct: 235 QK-YEKISEKKMSTPVEVLC 253 >3SV0-A nrPDB Length = 483 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 58/237 (24%), Positives = 101/237 (42%), Gaps = 23/237 (9%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH- 75 +++ + IGSG+FG L + T E VA+K +E + E +R L+ Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRILQGG 62 Query: 76 ---PNIVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 PN VR+ V + ++M+ S +L+ + S Q+++ V Sbjct: 63 TGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMINRVE 117 Query: 131 YCHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTP 181 + HS HRD+K +N L+ G A ++ I DFG +K + + + K+ GT Sbjct: 118 FVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTA 177 Query: 182 AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK 238 Y + L E + D+ S G L L G+ P++ + +K ++I K Sbjct: 178 RYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQK-YEKISEKK 232 >4TN6-A nrPDB Length = 318 Score = 161 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 100/244 (40%), Gaps = 17/244 (6%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + +RY + IGSG+FG L D E VA+K +E + E ++ ++ Sbjct: 3 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQG 61 Query: 76 -PNIVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 I + + ++ME S +L+ +FS Q++S + Y Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYI 119 Query: 133 HSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSK--------SSVLHSQPKSTVGTPAY 183 HS HRD+K +N L+ G + I DFG +K + + + K+ GT Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 + L E + D+ S G L +G+ P++ + R+ +RI K S P Sbjct: 180 ASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQGLKAA-TKRQKYERISEKKMSTPI 237 Query: 244 DIRI 247 ++ Sbjct: 238 EVLC 241 >4F9B-A nrPDB Length = 361 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 107/349 (30%), Gaps = 99/349 (28%) Query: 19 SDRYDFVKDIGSGNFGVARLMRDKLT---KELVAVKYIERGDKIDENVQREIINHRSLRH 75 S+ + IG G F L +L +E +A+K++ I L+ Sbjct: 20 SNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IRIAAELQC 72 Query: 76 -------PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 N++ K H+ I M Y + + + S E R + L Sbjct: 73 LTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKA 129 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---------------- 172 + H I HRD+K N L + + DFG ++ + Sbjct: 130 LKRIHQFGIVHRDVKPSNFLYNRRLKKYA-LVDFGLAQGTHDTKIELLKFVQSEAQQERC 188 Query: 173 -------------QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 Q GTP + APEVL + D+WS GV +L G YPF Sbjct: 189 SQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFY 248 Query: 220 DPEE-----------------------------------PRDYRKTIQRILSVKYSIPD- 243 + +D RK +R+ + S P Sbjct: 249 KASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKL 308 Query: 244 -------------DIRISPECCHLISRIFVADPATRISIPEIKTHSWFL 279 + E L+ ++ +PA+RI+ E H +F Sbjct: 309 TSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 >2QLU-A nrPDB Length = 314 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 104/287 (36%), Gaps = 44/287 (15%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF 81 ++ G FG + L + VAVK DK +REI + ++H N+++F Sbjct: 17 LQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 74 Query: 82 KEVILTPT----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS--- 134 + L +I + G L + + + +E + + G+SY H Sbjct: 75 IAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVP 133 Query: 135 --------MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST---VGTPAY 183 I HRD K +N LL + DFG + P T VGT Y Sbjct: 134 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAV--LADFGLAVRFEPGKPPGDTHGQVGTRRY 191 Query: 184 IAPEVLLRQEYDGK----IADVWSCGVTLYVMLVGA-----------YPFEDPEEPRDYR 228 +APEVL + D+++ G+ L+ ++ PFE+ Sbjct: 192 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 251 Query: 229 KTIQRI---LSVKYSIPDDIRISPECCHL---ISRIFVADPATRISI 269 + +Q + ++ +I D P L I + D R+S Sbjct: 252 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4MWI-A nrPDB Length = 294 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 105/256 (41%), Gaps = 27/256 (10%) Query: 38 LMRDKLTKELVAVKYIERGD-----KIDENVQREIINHRSLRHPNIVRFKEVIL----TP 88 L + + + VA+K ++ + + +EI + PNI+R + + TP Sbjct: 40 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 99 Query: 89 THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI--CHRDLKLEN 146 +I+MEY G L E + + + G+ H + H ++ N Sbjct: 100 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSN 159 Query: 147 TLLDGSPAPRLKICDFGYSKSSVLHS-----QPKSTVGTPAYIAPEVLLR--QEYDGKIA 199 L+ + ++K+ F K+ S + V + AY++P+ L +YD K + Sbjct: 160 FLV--TQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVK-S 216 Query: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY-SIPDDIRISPECCHLISRI 258 +++S G+ L+ + G PF+ + I+++++VK P E +I Sbjct: 217 EIYSFGIVLWEIATGDIPFQGCNS-----EKIRKLVAVKRQQEPLGEDCPSELREIIDEC 271 Query: 259 FVADPATRISIPEIKT 274 DP+ R S+ EI Sbjct: 272 RAHDPSVRPSVDEILK 287 >2CHL-A nrPDB Length = 351 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 102/250 (40%), Gaps = 19/250 (7%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 M ++ + K IG GNFG RL ++ T E VA+K +E + E ++ Sbjct: 22 SMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYK 80 Query: 72 SLRH-PNIVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSG 128 L I + + A+++E S +L++ FS QL+S Sbjct: 81 QLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFSLKTVLMIAIQLISR 138 Query: 129 VSYCHSMQICHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKST 177 + Y HS + +RD+K EN L+ + I DF +K + + + KS Sbjct: 139 MEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSL 198 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 GT Y++ L +E + D+ + G L G+ P++ + ++ Q+I Sbjct: 199 TGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDT 256 Query: 238 KYSIPDDIRI 247 K + P ++ Sbjct: 257 KRATPIEVLC 266 >2QKW-B nrPDB Length = 321 Score = 156 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 93/269 (34%), Gaps = 31/269 (11%) Query: 28 IGSGNFGVARLMRDKLTKELVAVK-YIERGDKIDENVQREIINHRSLRHPNIVRFKEVIL 86 IG G FG + VA+K + E + EI RHP++V Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 87 TPTHLAIIMEYASGGELYERICNAG----RFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 + +I +Y G L + + S ++ G+ Y H+ I HRD+ Sbjct: 106 ERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDV 165 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQP---KSTVGTPAYIAPEVLLRQEYDGKIA 199 K N LLD + P KI DFG SK Q GT YI PE ++ K + Sbjct: 166 KSINILLDENFVP--KITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEK-S 222 Query: 200 DVWSCGVTLYVMLVGA------YPFE---------DPEEPRDYRKTIQRILSVKYSIPDD 244 DV+S GV L+ +L P E + + + L+ K Sbjct: 223 DVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPESL 282 Query: 245 IRISPECCHLISRIFVADPATRISIPEIK 273 + + R S+ ++ Sbjct: 283 RKFGDTAV----KCLALSSEDRPSMGDVL 307 >2CMW-A nrPDB Length = 310 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 99/240 (41%), Gaps = 20/240 (8%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH--PNIVR 80 K IG GNFG RL ++ T E VA+K +E + E ++ L + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 81 FKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + A+++E S +L++ F+ QLLS + Y HS + Sbjct: 62 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 139 HRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTVGTPAYIAPE 187 +RD+K EN L+ + + I DFG +K + + + KS GT Y++ Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 L +E + D+ + G L G+ P++ + ++ Q+I K + P + Sbjct: 180 THLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRNTPIEALC 237 >4NT4-A nrPDB Length = 312 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 105/259 (40%), Gaps = 29/259 (11%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHR 71 M ++ + K IG GNFG RL ++ E VA+K K + E ++ Sbjct: 4 PMAVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHL-EYRFYK 62 Query: 72 SL-RH--------PNIVRFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARF 120 L H P I + A+++E S +L+ A +FS Sbjct: 63 LLGSHADNAPDGIPRIYHL-GTC-GGRYNAMVLELLGLSLEDLFNIC--ARKFSLKTVLM 118 Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SV 169 +QLL + Y HS + +RD+K EN L+ + R + I DFG +K + Sbjct: 119 IAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHI 178 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 + + KS GT Y++ + +E + D+ + G L G+ P++ + ++ Sbjct: 179 PYREHKSLTGTARYMSINTHMGRE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKE 236 Query: 230 TIQRILSVKYSIPDDIRIS 248 Q+I K + P ++ Sbjct: 237 RYQKIGDTKRATPIEVLCD 255 >2C47-A nrPDB Length = 313 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 54/241 (22%), Positives = 101/241 (41%), Gaps = 19/241 (7%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH-PNIV 79 + K IG GNFG RL ++ T E VA+K +E + E ++ L + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 80 RFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 + + A+++E S +L++ F+ QL++ + Y H+ + Sbjct: 64 QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 138 CHRDLKLENTLLDGSPAPR---LKICDFGYSKS--------SVLHSQPKSTVGTPAYIAP 186 +RD+K EN L+ R + I DFG +K + + + KS GT Y++ Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 L +E + D+ + G L G+ P++ + ++ Q+I K + P ++ Sbjct: 182 NTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATPIEVL 239 Query: 247 I 247 Sbjct: 240 C 240 >4BTK-A nrPDB Length = 337 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 90/228 (39%), Gaps = 15/228 (6%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP- 76 DR+ +K IG G FG D LT+E VA+K +E + + ++ E+ + L+ Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKD 112 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCHS 134 ++ RF ++M+ G L + + G F+ +Q+L + HS Sbjct: 113 HVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 135 MQICHRDLKLENTLLDGSPAPRLK--ICDFGYSKSSV-------LHSQPKSTVGTPAYIA 185 + HRD+K N + P+ K + DFG ++ GT Y + Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 231 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 +E G+ D+WS L VG P+ ++ ++ Sbjct: 232 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 278 >6BFN-A nrPDB Length = 342 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 50/226 (22%), Positives = 83/226 (36%), Gaps = 26/226 (11%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDK-----IDENVQREIINHRSLRHPNIVRF 81 IG G FG + T + AVK ++ + ++ E+ RHPNIV F Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 82 KEVILTPTHLAIIMEYASGGELYERIC----NAGRFSEDEARFFFQQLLSGVSYCH--SM 135 ++ + G L +R+ S + + + H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK----------SSVLHSQPKSTVGTPAYIA 185 + H D+K N LLD P K+ DFG ++ S + ++ ++ GT AY+ Sbjct: 147 SLIHGDIKSSNVLLDERLTP--KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL- 203 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTI 231 PE ++ D +S GV + L G + Y K + Sbjct: 204 PEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 249 >4NFN-A nrPDB Length = 309 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 90/228 (39%), Gaps = 15/228 (6%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP- 76 DR+ +K IG G FG D LT+E VA+K +E + + ++ E+ + L+ Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKD 77 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCHS 134 ++ RF ++M+ G L + + G F+ +Q+L + HS Sbjct: 78 HVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 135 MQICHRDLKLENTLLDGSPAPRLK--ICDFGYSKSSV-------LHSQPKSTVGTPAYIA 185 + HRD+K N + P+ K + DFG ++ GT Y + Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 196 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQR 233 +E G+ D+WS L VG P+ ++ ++ Sbjct: 197 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 243 >5X18-A nrPDB Length = 295 Score = 150 bits (380), Expect = 7e-37, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 97/234 (41%), Gaps = 19/234 (8%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH-PNIV 79 Y K IG G+FGV + + VA+K E ++ E ++ L PNI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIK-FEPRKTEAPQLRDEYKTYKILNGTPNIP 66 Query: 80 RFKEVILTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 H ++++ S +L++ +FS Q+++ + H+ + Sbjct: 67 YAYYFGQEGLHNILVIDLLGPSLEDLFDWC--GRKFSVKTVVQVAVQMITLIEDLHAHDL 124 Query: 138 CHRDLKLENTLLDGSPAP---RLKICDFGYS--------KSSVLHSQPKSTVGTPAYIAP 186 +RD+K +N L+ P + + DFG + K + + + KS GT Y++ Sbjct: 125 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 187 EVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 L +E + D+ + G + L G P++ + P + +K ++I K S Sbjct: 185 NTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQK-YEKIGEKKRS 236 >5X1R-A nrPDB Length = 302 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 99/287 (34%), Gaps = 36/287 (12%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---------------RG 56 +P + + ++ + IG G FG+ D + +A+K RG Sbjct: 13 SLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRG 72 Query: 57 DKIDENVQ-------REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERI-C 108 ++ + Q +E HP ++ + ++ SG L Sbjct: 73 ERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQ 132 Query: 109 NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS 168 + E R L S ++ H HRD+ L+N + S P + DFG ++ Sbjct: 133 QPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV--LLDFGSARKE 190 Query: 169 VLHSQPKSTVGTPAYIAPEVLLRQEYD---GKIADVWSCGVTLYVMLVGAYPFEDPEEPR 225 + + ++ + AP + D G D+++ G L+ ++VG+ P R Sbjct: 191 IGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP--PVSVVR 248 Query: 226 DYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRI-SIPE 271 + Q + + SPE + R P R +I E Sbjct: 249 SIEDSYQPLTERRP-----AGYSPELLRTVDRALALKPEDRPQTIDE 290 >4M69-B nrPDB Length = 283 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 93/252 (36%), Gaps = 23/252 (9%) Query: 39 MRDKLTKELVAVKYIERGD-----KIDENVQREIINHRSLRHPNIVRFKEVILT----PT 89 R + + V +K + EI + PNI+R + + P Sbjct: 26 YRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPP 85 Query: 90 HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL 149 +I+MEY G L E + + + G+ H + HR++ + L+ Sbjct: 86 EFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV 145 Query: 150 DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLR--QEYDGKIADVW 202 G ++K+ F SK+ S+ + Y++PE L YD K A+++ Sbjct: 146 AG--GYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK-AEIY 202 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G+ L+ + G PFE + +K + + K P +I+ + Sbjct: 203 SFGIVLWEIATGKIPFEGCDS----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHE 258 Query: 263 PATRISIPEIKT 274 P+ R S+ I Sbjct: 259 PSQRPSVDGILE 270 >1CSN-A nrPDB Length = 298 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 23/238 (9%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH----P 76 Y + IG G+FGV + L + VA+K+ R + ++ E ++ L P Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQ-LRDEYRTYKLLAGCTGIP 69 Query: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQQLLSGVSYCHSM 135 N+ H ++++ G L + + GR FS +Q+L+ V H Sbjct: 70 NV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEK 125 Query: 136 QICHRDLKLENTLL---DGSPAPRLKICDFGY--------SKSSVLHSQPKSTVGTPAYI 184 + +RD+K +N L+ + A + + DFG +K + + + K+ GT Y+ Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 185 APEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP 242 + L +E + D+ + G L G+ P++ + + +K +RI K S P Sbjct: 186 SINTHLGRE-QSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQK-YERIGEKKQSTP 241 >4BTF-A nrPDB Length = 469 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 93/252 (36%), Gaps = 23/252 (9%) Query: 39 MRDKLTKELVAVKYIERGD-----KIDENVQREIINHRSLRHPNIVRFKEVILT----PT 89 R + + V +K + EI + PNI+R + + P Sbjct: 212 YRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPP 271 Query: 90 HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL 149 +I+MEY G L E + + + G+ H + HR++ + L+ Sbjct: 272 EFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV 331 Query: 150 DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-----YIAPEVLLR--QEYDGKIADVW 202 G ++K+ F SK+ S+ + Y++PE L YD K A+++ Sbjct: 332 AG--GYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK-AEIY 388 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVAD 262 S G+ L+ + G PFE + +K + + K P +I+ + Sbjct: 389 SFGIVLWEIATGKIPFEGCDS----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHE 444 Query: 263 PATRISIPEIKT 274 P+ R S+ I Sbjct: 445 PSQRPSVDGILE 456 >3QD2-B nrPDB Length = 332 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 54/327 (16%), Positives = 97/327 (29%), Gaps = 85/327 (25%) Query: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERG------------------------ 56 ++ ++ +G G FGV ++K+ A+K I Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 57 --------DKIDENVQRE---------------------------IINHRSLRHPNIVRF 81 + E Q E I N V Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 82 KEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE---ARFFFQQLLSGVSYCHSMQIC 138 + +L I M+ L + + + E F Q+ V + HS + Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQ-------------PKSTVGTPAYIA 185 HRDLK N +K+ DFG + + VGT Y++ Sbjct: 187 HRDLKPSNIFFTMDDV--VKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE + Y K D++S G+ L+ +L + + I + ++K+ + Sbjct: 245 PEQIHGNNYSHK-VDIFSLGLILFELLY------SFSTQMERVRIITDVRNLKFPLLFTQ 297 Query: 246 RISPECCHLISRIFVADPATRISIPEI 272 + E ++ + P R +I Sbjct: 298 KYPQE-HMMVQDMLSPSPTERPEATDI 323 >3G2F-A nrPDB Length = 336 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 101/302 (33%), Gaps = 54/302 (17%) Query: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPN 77 D D ++ IG G +G L + VAVK ++ + ++ I + H N Sbjct: 11 DLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDN 68 Query: 78 IVRFK---EVILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 I RF E + + ++MEY G L + + + + G++Y Sbjct: 69 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTRGLAYL 127 Query: 133 H---------SMQICHRDLKLENTLLDGSPAPRLKICDFGYS---------KSSVLHSQP 174 H I HRDL N L+ I DFG S + + Sbjct: 128 HTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV--ISDFGLSMRLTGNRLVRPGEEDNAA 185 Query: 175 KSTVGTPAYIAPEVLLR------QEYDGKIADVWSCGVTLYVMLVGAY-PFEDPEEPRDY 227 S VGT Y+APEVL E K D+++ G+ + + + F P Sbjct: 186 ISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQ 245 Query: 228 R------------KTIQRILSVKYSIPD----DIRISPECCHL---ISRIFVADPATRIS 268 + +Q ++S + P S L I + D R++ Sbjct: 246 MAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLT 305 Query: 269 IP 270 Sbjct: 306 AQ 307 >5J0A-A nrPDB Length = 300 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 97/285 (34%), Gaps = 36/285 (12%) Query: 24 FVKDIGSGNFGV-ARLMRDKLTK---ELVAVKYIER------GDKIDENVQREIINHRSL 73 F++ +G G GV LM+ AVK I + + E +SL Sbjct: 13 FMQKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 74 RHPNIVRFKEVIL-TPTHLAIIMEYASGGELYERICNA-----GRFSEDEARFFFQQLLS 127 HPNIV ++ L + MEY L + I F + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 128 GVSYCHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS----TVGTPA 182 G+ Y H ++ H D+K N ++ G +KICD G S + + +GT Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFET-IKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 183 YIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYP-----------FEDPEEPRDYRKTI 231 + E + AD+++ G+TL+ M+ + P + +E + Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAY 250 Query: 232 QRILSVKYSI--PDDIRISPECCHLISRIFVADPATRISIPEIKT 274 L + I + + L S DP R S I Sbjct: 251 YAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >5M07-A nrPDB Length = 276 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 54/268 (20%), Positives = 91/268 (33%), Gaps = 42/268 (15%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER----GDKIDENVQREIINHRSLRHPN 77 Y V+ +G+ G L++ A+K + D+ QRE L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSM 135 I+ + L I M+Y G + + + + E + + Y H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 136 QICHRDLKLENTLLDGSPAP--RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQE 193 + HRD+ N +L A R+ + DFG + P+Y APE+ + Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSAGAD 198 Query: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 DG+ AD ++ +T + GA P + + P P+ Sbjct: 199 VDGR-ADQYALALTAIHLFAGAPPVDRSH-------------TGPLQPPKLSAFRPDLAR 244 Query: 254 L---ISRIFVADPATRIS----IPEIKT 274 L +SR PA R + Sbjct: 245 LDGVLSRALATAPADRFGSCREFADAMN 272 >3HNG-A nrPDB Length = 360 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 41/172 (23%), Positives = 74/172 (43%), Gaps = 17/172 (9%) Query: 110 AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 + ++ + Q+ G+ + S + HRDL N LL + +KICDFG ++ Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV--VKICDFGLARDIY 250 Query: 170 LHSQPKSTVGTP---AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPR 225 + T ++APE + + Y K +DVWS GV L+ + G P+ + Sbjct: 251 KNPDYVRKGDTRLPLKWMAPESIFDKIYSTK-SDVWSYGVLLWEIFSLGGSPYPGVQMDE 309 Query: 226 DYRKTIQ---RILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 D+ ++ R+ + +YS P+ +I + + DP R E+ Sbjct: 310 DFCSRLREGMRMRAPEYSTPEIYQI-------MLDCWHRDPKERPRFAELVE 354 Score = 76.1 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 36/108 (33%), Gaps = 9/108 (8%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLM-----RDKLTKELVAVKYIERGDKIDE--NVQREI 67 +R K +G G FG + T VAVK ++ G E + E+ Sbjct: 22 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTEL 81 Query: 68 INHRSL-RHPNIVRFKEVIL-TPTHLAIIMEYASGGELYERICNAGRF 113 + H N+V L +I+EY G L + + Sbjct: 82 KILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >4XHH-A nrPDB Length = 403 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 52/238 (21%), Positives = 93/238 (39%), Gaps = 17/238 (7%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + ++ + IGSG+FG + ++ E VA+ +E + E ++ L Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSG 61 Query: 76 PNIVRFKEVI-LTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 + F + A++++ S +L+ +FS Q++ V Y Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--KFSFKTVIMLALQMICRVQYI 119 Query: 133 HSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKSTVGTPAY 183 H HRD+K +N L+ G + + DFG SK + + + KS GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSI 241 + L E + D+ S G L G+ P++ + ++ RIL K I Sbjct: 180 ASVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLK-ATTKKQKYDRILEKKLCI 235 >3VHK-A nrPDB Length = 368 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 73/170 (42%), Gaps = 11/170 (6%) Query: 110 AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK--- 166 + + + Q+ G+ + S + HRDL N LL +KICDFG ++ Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNV--VKICDFGLARDIY 251 Query: 167 SSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPR 225 + + ++APE + + Y + +DVWS GV L+ + GA P+ + Sbjct: 252 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQ-SDVWSFGVLLWEIFSLGASPYPGVKIDE 310 Query: 226 DYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTH 275 ++ + ++ + PD +PE + + +P+ R + E+ H Sbjct: 311 EFCRRLKE--GTRMRAPDYT--TPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 74.9 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 39/106 (36%), Gaps = 9/106 (8%) Query: 15 IMHDSDRYDFVKDIGSGNFGVARLM----RDK-LTKELVAVKYIERGDKIDEN--VQREI 67 DR K +G G FG DK T VAVK ++ G E+ + E+ Sbjct: 24 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 83 Query: 68 INHRSL-RHPNIVRFKEVILTP-THLAIIMEYASGGELYERICNAG 111 + H N+V P L +I+E+ G L + + Sbjct: 84 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 129 >4XHL-A nrPDB Length = 394 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 17/245 (6%) Query: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRH 75 + ++ + IGSG+FG + ++ E VA+ +E + E +R L Sbjct: 3 LRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSG 61 Query: 76 PNIVRFKEVI-LTPTHLAIIMEYA--SGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 + F + A++++ S +L+ RFS Q+ + Y Sbjct: 62 GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYI 119 Query: 133 HSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKS--------SVLHSQPKSTVGTPAY 183 H HRD+K +N L+ G + + DFG SK + + + KS GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 + L E + D+ S G L G+ P++ + ++ RI+ K ++ Sbjct: 180 ASVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLK-ATTKKQKYDRIMEKKLNVSV 237 Query: 244 DIRIS 248 + S Sbjct: 238 ETLCS 242 >4RT7-A nrPDB Length = 415 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 46/211 (21%), Positives = 77/211 (36%), Gaps = 19/211 (9%) Query: 65 REIINHRSLRHPNIVRFKE-VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 RE+ H I + + EY + L E + + ++ F Sbjct: 198 REVQIHP--DSDQISGLHGNSFHSEDEI----EYENQKRLEEE-EDLNVLTFEDLLCFAY 250 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTP-- 181 Q+ G+ + HRDL N L+ +KICDFG ++ + S Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKV--VKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 182 -AYIAPEVLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKY 239 ++APE L Y K +DVWS G+ L+ + G P+ ++ K IQ + Sbjct: 309 VKWMAPESLFEGIYTIK-SDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN----GF 363 Query: 240 SIPDDIRISPECCHLISRIFVADPATRISIP 270 + + E ++ + D R S P Sbjct: 364 KMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 394 Score = 91.5 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 38/108 (35%), Gaps = 8/108 (7%) Query: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRD---KLTK--ELVAVKYIERGDKIDEN--VQ 64 D+ + +F K +GSG FG T VAVK ++ E + Sbjct: 57 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALM 116 Query: 65 REIINHRSL-RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAG 111 E+ L H NIV + +I EY G+L + + Sbjct: 117 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 164 >2PZI-A nrPDB Length = 681 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 97/282 (34%), Gaps = 42/282 (14%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKL-TKELVAVKYIERGDKID-- 60 +P + P P + +Y+ I G G L D+ V +K + + Sbjct: 64 SPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQ 123 Query: 61 ------ENVQREIINHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICN 109 E++ HP+IV+ + I+MEY G L Sbjct: 124 AMAMAERQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SK 175 Query: 110 AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 + EA + ++L +SY HS+ + + DLK EN +L +LK+ D G Sbjct: 176 GQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRI- 231 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 + GTP + APE++ D+++ G TL L P + Sbjct: 232 --NSFGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLPTRNG-------- 278 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPE 271 R + ++ L+ R DP R + E Sbjct: 279 ---RYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 97/282 (34%), Gaps = 42/282 (14%) Query: 4 APVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKL-TKELVAVKYIERGDKID-- 60 +P + P P + +Y+ I G G L D+ V +K + + Sbjct: 103 SPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQ 162 Query: 61 ------ENVQREIINHRSLRHPNIVRFKEVILTPTHL-----AIIMEYASGGELYERICN 109 E++ HP+IV+ + I+MEY G L Sbjct: 163 AMAMAERQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SK 214 Query: 110 AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV 169 + EA + ++L +SY HS+ + + DLK EN +L +LK+ D G Sbjct: 215 GQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE---QLKLIDLGAVSRI- 270 Query: 170 LHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRK 229 + GTP + APE++ D+++ G TL L P + Sbjct: 271 --NSFGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLPTRNG-------- 317 Query: 230 TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPE 271 R + ++ L+ R DP R + E Sbjct: 318 ---RYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAE 356 >4L00-A nrPDB Length = 304 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 92/269 (34%), Gaps = 28/269 (10%) Query: 25 VKDIGSGN-----FGVARLMRD-----KLTKELVAVKYIERGDK-IDENVQREIINHRSL 73 + +G G G +D + K V +K ++ + I R + Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV 89 Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA-GRFSEDEARFFFQQLLSGVSYC 132 H +IV V + ++ E+ GG L + + +QL S +SY Sbjct: 90 SHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYL 149 Query: 133 HSMQICHRDLKLENTLL-----DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 187 + H ++ +N LL D P +K+ D G + + + + +IAPE Sbjct: 150 EDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI---PWIAPE 206 Query: 188 VLLRQEYDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 + + AD WS G TL+ + G P +D R R V S Sbjct: 207 CVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSC----- 261 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTH 275 E L++R DP R I Sbjct: 262 --KELADLMTRCMNYDPNQRPFFRAIMRD 288 >5USZ-A nrPDB Length = 289 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 94/275 (34%), Gaps = 24/275 (8%) Query: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKEL-------VAVKYIERGDK-IDENVQ 64 + ++ F + +G G F + + V +K +++ + E+ Sbjct: 1 VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFF 60 Query: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR-FSEDEARFFFQ 123 L H ++V V + ++ E+ G L + + + Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK 120 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLL------DGSPAPRLKICDFGYSKSSVLHSQPKST 177 QL + + + + H ++ +N LL P +K+ D G S + + + Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 178 VGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV 237 + ++ PE + + D WS G TL+ + G ++P + +++ Sbjct: 181 I---PWVPPECIENPKNLNLATDKWSFGTTLWEICSG------GDKPLSALDSQRKLQFY 231 Query: 238 KYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 + + E +LI+ +P R S I Sbjct: 232 EDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAI 266 >5C01-A nrPDB Length = 342 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 78/246 (31%), Gaps = 19/246 (7%) Query: 39 MRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEY 97 RD+ + V +K ++ I + H ++ V + ++ EY Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 160 Query: 98 ASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTL-----LDG 151 G L + G QQL S +SY + + H ++ N L L Sbjct: 161 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 220 Query: 152 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD-GKIADVWSCGVTLYV 210 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 221 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 277 Query: 211 MLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 + G P + ++ + S P L S+ +P R S Sbjct: 278 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-------LTSQCLTYEPTQRPSF 330 Query: 270 PEIKTH 275 I Sbjct: 331 RTILRD 336 >4WOV-A nrPDB Length = 317 Score = 118 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 78/246 (31%), Gaps = 19/246 (7%) Query: 39 MRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEY 97 RD+ + V +K ++ I + H ++ V + ++ EY Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 137 Query: 98 ASGGELYERICN-AGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTL-----LDG 151 G L + G QQL S +SY + + H ++ N L L Sbjct: 138 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 197 Query: 152 SPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD-GKIADVWSCGVTLYV 210 +P +K+ D G ++ + + ++APE L D W G TL Sbjct: 198 GTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLE 254 Query: 211 MLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISI 269 + G P + ++ + S P L S+ +P R S Sbjct: 255 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT-------LTSQCLTYEPTQRPSF 307 Query: 270 PEIKTH 275 I Sbjct: 308 RTILRD 313 >5UV4-A nrPDB Length = 311 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 43/203 (21%), Positives = 76/203 (37%), Gaps = 14/203 (6%) Query: 26 KDIGSGNFGVARLMRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIVRFKEV 84 + IG G + ++ VK+++ G K + REI S+RHPN+V + Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGY 89 Query: 85 ILTPT--HLAIIMEYASGGELYERI-----CNAGRFSEDEARFFFQQLLSGVSYCHSMQI 137 P +I +YA L + N S + + + Y H+ ++ Sbjct: 90 YWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERV 149 Query: 138 C-HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--GTPAYIAPE-VLLRQE 193 H ++K N L+ S L + D+ + + + G Y PE + Sbjct: 150 IPHGNIKSSNVLIQNSTPSAL-VTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208 Query: 194 YDGKIADVWSCGVTLYVMLVGAY 216 +DV++ GV L +L G Sbjct: 209 CPSLKSDVYAFGVILLELLTGKI 231 >5OAT-A nrPDB Length = 411 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 108/311 (34%), Gaps = 72/311 (23%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKEL-----VAVKYIERGDKIDE------------- 61 + K I G GV + K + A+K + D + Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 62 ------------NVQREIINHRSLR--HPNIVRFKEVILT-----------------PTH 90 N + E+ N R HPNIV V Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 91 LAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLD 150 L ++M+ L + A S + QLL GV++ + I HRDLK +N LLD Sbjct: 131 LFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLD 187 Query: 151 GS--PAPRLKICDFG--YSKSSVLHSQPKSTV-----GTPAYIAPEVLLRQEYDG----- 196 S +P L I DFG + + S P ++ G A +APE++ ++ Sbjct: 188 TSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNY 247 Query: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 AD+W+ G Y + PF P +++ + + +P I+ L++ Sbjct: 248 SKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQ------ALVA 301 Query: 257 RIFVADPATRI 267 + +P R+ Sbjct: 302 NLLKRNPNKRL 312 >6EQI-C nrPDB Length = 433 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 71/371 (19%), Positives = 117/371 (31%), Gaps = 80/371 (21%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTK-----ELVAVKYI------ERGDKIDENVQRE-- 66 D D + I G V + K + +AVK + I + + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 67 -------------IINHRSLR-----HPNIVRFKEVILTPTH------------------ 90 I N + HPNIVR V Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 91 ---------LAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 L ++M+ L E + + + + QLL V++ + I HRD Sbjct: 135 PEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISHRD 192 Query: 142 LKLENTLLD---GSPAPRLKICDFGYSKSSVLH-------SQPKSTVGTPAYIAPEVLLR 191 LK +N L+D G P + I DFG + S+ + G A +APE+ Sbjct: 193 LKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANA 252 Query: 192 QEYDG-----KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 + K +D+W+ G Y + PF D K + + + Sbjct: 253 KPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT-----MKLLSKSYKEEDLPELPDT 307 Query: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSL 306 I +L+S + R+ T + P+ + E+ T E Q + L Sbjct: 308 IPFIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSSWLKENYTLPNSNEIIQWLLCL 367 Query: 307 DTIMQIISEAT 317 + + + T Sbjct: 368 SSKVLCERDIT 378 >4I94-A nrPDB Length = 300 Score = 107 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 71/239 (29%), Gaps = 15/239 (6%) Query: 35 VARLMRDKLTKELVAVKYIERGD-KIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAI 93 V + + +AVK R E LR+ + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLL 102 Query: 94 IMEYASGGELYERICN--AGRFSEDEARFFFQQLLSGVSYCHSMQ-ICHRDLKLENTLLD 150 I E+ L + + + + + + YC S + DL L D Sbjct: 103 IAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFD 162 Query: 151 GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYV 210 PRL FG K+S + + A+ PE L + ++S G L Sbjct: 163 DDANPRLSC--FGLMKNSRDGKSYSTNL---AFTPPEYLRTGRVTPESV-IYSFGTLLLD 216 Query: 211 MLVGA--YPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRI 267 +L G P + RD + ++ D E L SR +P R Sbjct: 217 LLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDG--TELIRLASRCLQYEPRERP 273 >4L68-A nrPDB Length = 340 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 84/257 (32%), Gaps = 22/257 (8%) Query: 34 GVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAI 93 G +AVK++ + + E+ LRH N+ + + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFL 112 Query: 94 IMEYASGGELYERI-CNAGRFSEDEARFFFQQLLSGVSYCHS---MQICHRDLKLENTLL 149 + +Y S G L+ + N G G+++ H I H+++ L+ Sbjct: 113 VYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILI 172 Query: 150 DGSPAPRLKICDFGYSKSSVL-----HSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSC 204 D R I D G ++ V S +G Y+APE K DV+ Sbjct: 173 DEDFDAR--IIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKG-DVYGL 229 Query: 205 GVTLYVMLVGAYPFEDP---EEPRDYRKTIQRILSVKYSIPDDIR---ISPECCHLIS-- 256 GV L + G D+ K ++ + + ++IR E + Sbjct: 230 GVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIA 289 Query: 257 -RIFVADPATRISIPEI 272 + P R S+ + Sbjct: 290 LNCVSSRPKERWSMFQA 306 >6J6I-B nrPDB Length = 351 Score = 100 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 40/195 (20%), Positives = 77/195 (39%), Gaps = 20/195 (10%) Query: 39 MRDKLTKELVAVKYIERGDKIDENVQ-REIIN-----HRSLRHPNIVRFKEVILTPTHLA 92 R ++ +K + + + +E+ N R H N ++ L Sbjct: 75 YRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPV 134 Query: 93 IIMEYASGGELYER---ICNAGR--FSEDEARFFFQQLLSGVSYCHS---MQICHRDLKL 144 ++ E+A G + +R I N +++ + V+Y H+ I HRD+K Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 145 ENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVGTPAYIAPEVLLRQEYDGKIADV 201 + LD + K+ D +S S + + +GT YI P + + + + DV Sbjct: 195 MHVFLDKNWTA--KLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDV 251 Query: 202 WSCGVTLYVMLVGAY 216 +S G+ L V++ G Sbjct: 252 YSFGICLLVIITGKP 266 >4JRN-A nrPDB Length = 372 Score = 99 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 88/288 (30%), Gaps = 57/288 (19%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKY-IERGDKIDE---NVQREIINHRSLR-------- 74 +GSG F D T E +AVK + + DE ++QRE +R+ Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 75 ---HPNIVR---------------FKEVILTPTHLAIIMEYASGGELYERIC-------- 108 +V + ++ + ++ + I Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 109 NAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSS 168 N F + Q + V+ + I H D+K N LL RL + DFG + Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKD--GRLFLGDFG---TY 249 Query: 169 VLHSQPKSTVGTPAYIAPE--VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRD 226 +++ +GTP Y PE D W G+TLY + P + D Sbjct: 250 RINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP-TPADGIWD 308 Query: 227 YRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKT 274 Y D LI + DP R+ + Sbjct: 309 YLH-----------FADCPSTPELVQDLIRSLLNRDPQKRMLPLQALE 345 >5UU1-A nrPDB Length = 324 Score = 95.7 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 84/235 (35%), Gaps = 39/235 (16%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVA---VKY-----------------IERG 56 + +++ K IGSG FG+ L E A VK + + Sbjct: 13 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 72 Query: 57 DKIDENVQREIINHRSLRHPNIVRFKEVILTP----THLAIIMEYASGGELYERICNAGR 112 D I + ++R + L + I F LT ++ ++ME G +L + G Sbjct: 73 DCIKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGT 126 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 F + ++L + Y H + H D+K N LL ++ + D+G S + Sbjct: 127 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 186 Query: 173 QP--------KSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE 219 K GT + + + + +DV G + L G P+E Sbjct: 187 NHKQYQENPRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLPWE 240 >4IX6-A nrPDB Length = 350 Score = 92.2 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 53/316 (16%), Positives = 91/316 (28%), Gaps = 68/316 (21%) Query: 27 DIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR---HPN----IV 79 +GSGNFG K +++V ++ + + + H N Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHVHANAKGTCA 82 Query: 80 RFKEVIL----TPTHLA--IIME---YA---SGGELYERICNAGRFSEDEA--------- 118 RF I + + E G E + G A Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 119 ---RFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPK 175 + ++LL ++ H + HRD+K N + LK+ D G + + + Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 176 STV-----GTPAYI-APEVLLRQEYDGKIA----------------DVWSCGVTLYVMLV 213 + P Y A E+ L + D WS G + + V Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV 262 Query: 214 -------GAYPFEDPEEPRDYR-KTIQRILSVKYSIPDDIRISPE---CCHLISRIFVAD 262 G F + Y + S +Y D + L R+ A+ Sbjct: 263 VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQRLMEAE 322 Query: 263 PATRISIPEIKTHSWF 278 R S +H++F Sbjct: 323 RDARASCEAALSHAFF 338 >2RSV-A nrPDB Length = 403 Score = 91.5 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 90/279 (32%), Gaps = 53/279 (18%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELV------AVK-------------YIERGDKID 60 + IG G FG L D + E V VK + Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPT----HLAIIMEYASGGELYERIC--NAGRFS 114 E +Q+ I R L++ + ++ L + +IM+ G ++I NA RFS Sbjct: 101 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFS 157 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 ++L + Y H + H D+K N LL+ ++ + D+G + Sbjct: 158 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 217 Query: 175 KSTV--------GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRD 226 K GT + + + + D+ G + L G P+ED Sbjct: 218 KEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWED------ 270 Query: 227 YRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPAT 265 + KY IR L+ + F P Sbjct: 271 ------NLKDPKYVRDSKIRYRENIASLMDKCF---PEK 300 >2LAV-A nrPDB Length = 361 Score = 90.3 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 90/279 (32%), Gaps = 53/279 (18%) Query: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELV------AVK-------------YIERGDKID 60 + IG G FG L D + E V VK + Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 61 ENVQREIINHRSLRHPNIVRFKEVILTPT----HLAIIMEYASGGELYERIC--NAGRFS 114 E +Q+ I R L++ + ++ L + +IM+ G ++I NA RFS Sbjct: 94 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFS 150 Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 ++L + Y H + H D+K N LL+ ++ + D+G + Sbjct: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 Query: 175 KSTV--------GTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRD 226 K GT + + + + D+ G + L G P+ED Sbjct: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVA-PSRRGDLEILGYCMIQWLTGHLPWED------ 263 Query: 227 YRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPAT 265 + KY IR L+ + F P Sbjct: 264 ------NLKDPKYVRDSKIRYRENIASLMDKCF---PEK 293 >5CLR-A nrPDB Length = 451 Score = 88.0 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 35/191 (18%), Positives = 68/191 (35%), Gaps = 22/191 (11%) Query: 37 RLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTH--LAII 94 + + +K ++ + E L R I+ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHYIL 150 Query: 95 MEYASGGELYERICNAGRFSED-----EARFFFQQLLSGVSYCHSMQICHRDLKLENTLL 149 + G +L NA + + E + V H + + HRDLK N +L Sbjct: 151 TTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209 Query: 150 DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY--DGKIADVWSCGVT 207 D + DFG S S ++ GT +Y+APE+ ++++ +++D+++ + Sbjct: 210 DADMQCH--LVDFGSSSS--DKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYS 265 Query: 208 LYVMLVGAYPF 218 L + PF Sbjct: 266 LDELFN---PF 273 >4O1O-A nrPDB Length = 717 Score = 82.2 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 98/301 (32%), Gaps = 54/301 (17%) Query: 46 ELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGELY 104 + VAVK G Q+E+ +S R + N+V F + L + + L Sbjct: 370 QEVAVKRFSEG---STRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY-TLQ 425 Query: 105 ERICNAG----RFSEDE-ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKI 159 E + N EDE AR L + H H+DL+ +N L+D + Sbjct: 426 EHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF--L 483 Query: 160 CDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCG-VTLYVMLVGAYPF 218 DF S Q D+ + G + LYV+ G F Sbjct: 484 ADFDKSIKWAEDPQKIKR----------------------DLEALGLLVLYVVKKGDISF 521 Query: 219 EDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVA--DPATRISIPEIKTHS 276 E + + + + IQ PD+ E LI +F + R+S + H Sbjct: 522 ETLKN-QSFEEVIQG-------SPDE-----ETRDLIHHLFHPGDNVEDRLSS--LLAHP 566 Query: 277 WFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQ--IISEATIPAVRNRCLDDFMTDNL 334 +F + + ++Q +T A +D F+ + + Sbjct: 567 FFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTSELSTSFAQWTTKIDSFVMEEM 626 Query: 335 D 335 + Sbjct: 627 N 627 >6G4J-A nrPDB Length = 315 Score = 81.8 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 67/206 (32%), Gaps = 32/206 (15%) Query: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHP 76 + + Y K +G G G+ L + VA+K ++ E+ +S Sbjct: 23 WNGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV----SDDSLSITSEVNVLKSFSKA 76 Query: 77 NIVRFKEVILTPTHLAI----------IMEYASGGELYERICNAGRFSEDEARFFFQQLL 126 V I MEY G L + + + G + QLL Sbjct: 77 QSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQLL 133 Query: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 S +S H DLK +N ++ G P R++ D G + + + Y Sbjct: 134 SSLSVLHQQGWIFGDLKPDNLIVTG-PPARIRCIDVGGTTKEGRAIKEYTEFYDRGY--- 189 Query: 187 EVLLRQEYDGKIA----DVWSCGVTL 208 Y + A D+++ + + Sbjct: 190 -----WGYGTRKAEPSYDLFAVAMIM 210 >6EAS-A nrPDB Length = 308 Score = 78.4 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 44/264 (16%), Positives = 85/264 (32%), Gaps = 38/264 (14%) Query: 31 GNFGVARLMRDKLT-KELVAVKYIERGDKIDENVQRE------IINHRSLRHPNIVRFKE 83 G+ L + L+ +AV D + + E I N + H N + Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLG 108 Query: 84 VILTPTHL--AIIMEYASGGELYERIC--NAGRFSEDEARFFFQQLLSGVSYCHSMQ--I 137 ++ EYA G L+E + A + + + + H +Q Sbjct: 109 YCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPA 168 Query: 138 CHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP--EVLLRQEYD 195 R+ L A K+ D + + H+ + +P E ++R+ Sbjct: 169 ALRNFDSTTVYLTDDFAA--KVSDLEFWNDAKGHNSTTNNELA---FSPDMEDIVRK--- 220 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDY--RKTIQRILSVKYSIPDDIRISPE--- 250 G+ L +L G P + + P + + + + ++ I I PE Sbjct: 221 --------YGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTA 272 Query: 251 --CCHLISRIFVADPATRISIPEI 272 C ++ DP R + E+ Sbjct: 273 RALCEVVRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 76.8 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 47/296 (15%), Positives = 86/296 (29%), Gaps = 57/296 (19%) Query: 13 MPIMHDSDRYDFVKDI-------GSGNFGVARLMR-----DKLTKELVAVKYIERGDKID 60 +P + + + G G F D K+ +K + Sbjct: 51 LPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV--QKPANP 108 Query: 61 ENVQREIINHRSLR----HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSED 116 L+ H ++F L ++ E S G L I E Sbjct: 109 WEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEK 167 Query: 117 -----EARFFFQQLLSGVSYCHSMQICHRDLKLENTLL---------DGSPAPRLKICDF 162 F ++L + H +I H D+K +N +L + + L + D Sbjct: 168 VMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDL 227 Query: 163 GYS---KSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAY--- 216 G S K + + T + E+L + ++ + D + T+Y ML G Y Sbjct: 228 GQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQ-IDYFGVAATVYCMLFGTYMKV 286 Query: 217 -----------PFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVA 261 F + + +L+ IPD + L+ + Sbjct: 287 KNEGGECKPEGLFRRLPHLDMWNEFFHVMLN----IPDCHHLPS--LDLLRQKLKK 336 >6EWX-A nrPDB Length = 484 Score = 75.3 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 46/199 (23%), Positives = 65/199 (32%), Gaps = 45/199 (22%) Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL------------------------- 149 E F QL +G+ + I HRDL LEN LL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 150 --------------DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 PRL I +F +K + + A +APE++ +Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 + D + G+ +Y +L PF E R + +P SP L Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF----EVRAQLRERDYRREDLPPLPTLSLYSPGLQQLA 382 Query: 256 SRIFVADPATRISIPEIKT 274 + ADP RI I E K Sbjct: 383 HLLLEADPIKRIRIGEAKR 401 >4OAU-C nrPDB Length = 699 Score = 73.7 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 106/307 (34%), Gaps = 53/307 (17%) Query: 45 KELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVILTPTHLAIIMEYASGGEL 103 K+ VAVK G QRE+ +S R + ++V F HL + + Sbjct: 366 KQEVAVKTFCEGSP---RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLE 422 Query: 104 YERICNAGRFSEDE----ARFFFQQLLSGVSYCH-SMQICHRDLKLENTLLDGSPAPRLK 158 + G E+E AR + V H S H+DL+ +N L+D A Sbjct: 423 ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH-- 480 Query: 159 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCG-VTLYVMLVGAYP 217 + DF S Q EV D+ G + LYV+ G+ Sbjct: 481 LADFDKSIKWAGDPQ-------------EV---------KRDLEDLGRLVLYVVKKGSIS 518 Query: 218 FEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSW 277 FED + + + +Q + E LI R+F R + ++ H + Sbjct: 519 FEDLK-AQSNEEVVQ------------LSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPF 565 Query: 278 FLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTD-NLDL 336 F + + + +S I++++ P+ ++ D + T N + Sbjct: 566 FWTWESRYRTLRNVGN---ESDIKTRKSESEILRLLQPG--PSEHSKSFDKWTTKINECV 620 Query: 337 DDDMDDF 343 M+ F Sbjct: 621 MKKMNKF 627 >4CI6-B nrPDB Length = 643 Score = 71.8 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 94/265 (35%), Gaps = 39/265 (14%) Query: 42 KLTKELVAVKYIERGDKIDENVQREIINHRSL-----RHPNIVRFKE--VILTPTHLA-- 92 K + LVA IER + ++ E+ ++ + +HPN+ V+ Sbjct: 66 KDKQRLVA--KIERS-IAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 93 IIMEYASG-------GELYERICNAGRFSED---EARFFFQQLLSGVSYCHSMQICHRDL 142 ++M+ G L + SE +F +LL ++ I H D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVW 202 K N + D + + + D G S QPK T ++ APE+ + + +DV+ Sbjct: 183 KPGNVVFDRASGEPV-VIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF 237 Query: 203 SCGVTLYVMLVGAYPFEDPEEPRDYR-------KTIQRILSVKYSI--PDDIRISPECCH 253 + + +L G FE E + + + + Y I P + Sbjct: 238 ---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTR 294 Query: 254 LISRIFVADPATRISIPEIKTHSWF 278 I+ I +R E + H + Sbjct: 295 FITDILGVSADSRPDSNEARLHEFL 319 >5VE6-A nrPDB Length = 492 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 46/209 (22%), Positives = 65/209 (31%), Gaps = 55/209 (26%) Query: 115 EDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL------------------------- 149 E F QL +G+ + I HRDL LEN LL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPP 266 Query: 150 ------------------------DGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIA 185 PRL I +F +K + + A +A Sbjct: 267 CSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLA 326 Query: 186 PEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI 245 PE++ +Y + D + G+ +Y +L PF E R + +P Sbjct: 327 PEIVSASQY--RKFDEFQTGILIYELLHQPNPF----EVRAQLRERDYRQEDLPPLPALS 380 Query: 246 RISPECCHLISRIFVADPATRISIPEIKT 274 SP L + ADP RI I E K Sbjct: 381 LYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >6BHC-A nrPDB Length = 438 Score = 69.1 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 96/278 (34%), Gaps = 52/278 (18%) Query: 39 MRDKLTKELVAVKYIERGDKIDENVQREIINHRSLR-HPNIVRFKEVILTP--------- 88 +D L AVK + K + + +SL H NI + L Sbjct: 79 AKDPLNN--YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWE 136 Query: 89 -------THLAIIMEYASGGELYERIC-------NAGRFSEDEARFFFQQLLSGVSYCHS 134 +H+ +I + + + + E + QL SG+ + Sbjct: 137 DPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKP 196 Query: 135 MQICHRDLKLENTLL-------------------DGSPAPRLKICDFGYSKSSVLHSQPK 175 + H DL+LEN LL S RL + +F +K P+ Sbjct: 197 YHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPE 256 Query: 176 STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL 235 +APE++ +Y K D + G+ +Y ML PF++ E ++ T + Sbjct: 257 ILRDQSR-LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLP 313 Query: 236 SVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 + + P S L S + +P+ RI I + K Sbjct: 314 RIPFRSP----YSRGLQQLASCLLNPNPSERILISDAK 347 >2JII-A nrPDB Length = 352 Score = 66.8 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 24/168 (14%), Positives = 57/168 (33%), Gaps = 13/168 (7%) Query: 85 ILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDL 142 + + +++ G L + SE +LL + + H + H ++ Sbjct: 127 VHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNV 185 Query: 143 KLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTV--------GTPAYIAPEVLLRQEY 194 EN +D ++ + +G++ + + V G +I+ ++ Sbjct: 186 TAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG- 244 Query: 195 DGKIADVWSCGVTLYVMLVGAYPFEDP-EEPRDYRKTIQRILSVKYSI 241 + +D+ S G + L G P+ + D K Q+ + Sbjct: 245 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPF 292 >6M7Z-A nrPDB Length = 319 Score = 62.2 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 42/260 (16%), Positives = 91/260 (35%), Gaps = 44/260 (16%) Query: 54 ERGDKIDENVQREIINHRS-LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR 112 + + + REI+ RS L P++ ++ LT I S G + + + Sbjct: 88 PKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLT-----YIFHPLSKGLVGDMLETGR- 141 Query: 113 FSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS 172 S + + +++ + H++ + HR ++L + + L G ++ + + Sbjct: 142 -SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLG----GLDTAAPIGT 196 Query: 173 QPKSTVGTPAY-IAPEV--------LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEE 223 + + VG APE+ L Q +DV+S GV Sbjct: 197 ETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV----------------- 239 Query: 224 PRDYRKTIQRILSVKYSIPDDIRISPECCHLI----SRIFVADPATRISIPEIKTHSWFL 279 +R +Q + + D + + L+ ++ +P R +I EI F Sbjct: 240 --AFRNLVQLLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFE 297 Query: 280 KNLPADLMNESNTGSQFQEP 299 D+ ++++ Sbjct: 298 GLNFEDIEEGKARPFRYKQN 317 >5GZ9-A nrPDB Length = 305 Score = 57.2 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 39/116 (33%), Gaps = 11/116 (9%) Query: 25 VKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEV 84 +K +G G L K K VA+ + R + E+ + +SL+ ++V Sbjct: 39 LKRVGEGAVKRVFLSEWKEHK--VALSRLTRLEM-KEDFLHGLQMLKSLQSEHVVTLVGY 95 Query: 85 ILTPTHLAIIMEYASGGELYER-----ICNAGRF-SEDEARFFFQQLLSGVSYCHS 134 I+ EY G L + + + +S ++Y H Sbjct: 96 CEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHH 149 >5GZA-A nrPDB Length = 290 Score = 56.4 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 39/118 (33%), Gaps = 11/118 (9%) Query: 23 DFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFK 82 VK IG G L + VA+ + D+ ++ + R+L+ ++V Sbjct: 28 RRVKLIGQGAVKKVYLSE--WQGQKVALSVLS-SDQYADDFLHGLSMLRALQSSHVVTLV 84 Query: 83 EVILTPTHLAIIMEYASGGE---LYERICNAG---RFSEDEARFFFQQLLSGVSYCHS 134 V + EY G L + R S ++ ++Y HS Sbjct: 85 GVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 >4CYJ-A nrPDB Length = 438 Score = 54.9 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 59/170 (34%), Gaps = 24/170 (14%) Query: 33 FGV---ARLMRDKLTKELVAVKYIERGDKIDEN-VQREIINHRSLRHPNIVRFKEVILT- 87 FG ++ A++ +E +E + + + + +++ +IV EV T Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTR 124 Query: 88 ---PTHLAIIMEYASG-GELYERICNAGR---------FSEDEARFFFQQLLSGVSYCHS 134 + L ++ L E E+ + Q+ + + HS Sbjct: 125 EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 135 MQICHRDLKLENTLLDGSPAPRLK---ICD---FGYSKSSVLHSQPKSTV 178 ++ R L+ +L RL I D FG + SV+ Q + V Sbjct: 185 NRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFV 234 >4AZW-A nrPDB Length = 471 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 41/139 (29%), Gaps = 20/139 (14%) Query: 33 FGVARLMR----DKLTKELVAVKYIERGDKIDENVQREIINHRS----LRHPNIVRFKEV 84 FG + + D L A E + + EI P + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKHELHNEIKFLTQPPAGFDAPAV---LAH 310 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 ++ME G L + + E + LL ++ H D++ Sbjct: 311 GENAQSGWLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKKGFWHDDVRP 367 Query: 145 ENTLLDGSPAPRLKICDFG 163 N ++D ++ DFG Sbjct: 368 WNVMVDARQ--HARLIDFG 384 >6G38-A nrPDB Length = 357 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 35/191 (18%), Positives = 57/191 (29%), Gaps = 52/191 (27%) Query: 6 VTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---------RG 56 GP+ +++ + IG G FG T VA+K I Sbjct: 27 SQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSH 84 Query: 57 DKIDENVQREIINHRS-----------------LRHPNIVR------FKEV--------- 84 K E + EII + L + V+ + Sbjct: 85 QKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKG 144 Query: 85 -------ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH-SMQ 136 L I++E+ GG E++ S A+ QL + ++ S++ Sbjct: 145 SANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS-SLATAKSILHQLTASLAVAEASLR 203 Query: 137 ICHRDLKLENT 147 HRDL N Sbjct: 204 FEHRDLHWGNV 214 >4AZV-A nrPDB Length = 569 Score = 52.2 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 41/139 (29%), Gaps = 20/139 (14%) Query: 33 FGVARLMR----DKLTKELVAVKYIERGDKIDENVQREIINHRS----LRHPNIVRFKEV 84 FG + + D L A E + + EI P + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA----EESQRNKYELHNEIKFLTQPPAGFDAPAV---LAH 310 Query: 85 ILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKL 144 ++ME G L + + E + LL ++ H D++ Sbjct: 311 GENAQSGWLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKQGFWHDDVRP 367 Query: 145 ENTLLDGSPAPRLKICDFG 163 N ++D ++ DFG Sbjct: 368 WNVMVDARQ--HARLIDFG 384 >4BWP-A nrPDB Length = 448 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 25/162 (15%), Positives = 43/162 (26%), Gaps = 37/162 (22%) Query: 37 RLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILT----PTHLA 92 T ++ I + + L+H N+V+ +EV T L Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLV 126 Query: 93 IIMEYASG-----------------------GEL--------YERICNAGRFSEDEARFF 121 ++ +Y G GE +R N E Sbjct: 127 LVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSI 186 Query: 122 FQQLLSGVSYCHSMQICHRDLKLENTLLDGSPA--PRLKICD 161 QL +G+ H + + L ++ G I D Sbjct: 187 IMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4CZY-B nrPDB Length = 429 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 45/127 (35%), Gaps = 16/127 (12%) Query: 37 RLMRDKLTKELVAVKYIERGDKIDENVQREIINH-RSLRHPNIVRFKEVILT----PTHL 91 ++ A++ IE +E + + + + NIV E T + L Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSL 120 Query: 92 AIIMEYASGGE-LYER----------ICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 + ++ E LY+ + N + E+ + Q+ + + H+ ++ R Sbjct: 121 IFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAAR 180 Query: 141 DLKLENT 147 L+L Sbjct: 181 CLELSKI 187 >3ENH-A nrPDB Length = 540 Score = 47.2 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 37/161 (22%), Positives = 58/161 (36%), Gaps = 33/161 (20%) Query: 28 IGSGNFGVARLMRDKLTKELVAVK-YIERG---DKIDENVQ-----REIINHRSLRH--- 75 IG G A + RD V +K +++G +++DEN++ RE ++ Sbjct: 344 IGKGA--EADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 76 --PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCH 133 P I +V L + M Y +G + I + ++ V H Sbjct: 402 PAPYI---FDVDLDNKRIM--MSYINGKLAKDVIEDN--------LDIAYKIGEIVGKLH 448 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP 174 + H DL N + D L I DFG K S L Sbjct: 449 KNDVIHNDLTTSNFIFDKD----LYIIDFGLGKISNLDEDK 485 >2W1Z-A nrPDB Length = 368 Score = 45.2 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 49/181 (27%), Gaps = 24/181 (13%) Query: 103 LYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDF 162 L QL+ + + H D ++ N LLD L Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT---- 233 Query: 163 GYSKSSVLHSQPKSTVGTPAYIAPE-----VLLRQEYD----GKIADVWSCGVTLYVMLV 213 G+ + S +G + PE +L +++ D W+ G+ +Y + Sbjct: 234 GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWC 292 Query: 214 GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIK 273 P + E +R + I L+ R+ + Sbjct: 293 ADLPNTEDAELGGIEWIYRRCKN----------IPQPVRALLEGFLRYSKEDRLLPLQAM 342 Query: 274 T 274 Sbjct: 343 E 343 >3BYV-A nrPDB Length = 377 Score = 45.2 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 21/184 (11%), Positives = 46/184 (25%), Gaps = 25/184 (13%) Query: 103 LYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDF 162 L Q++ ++ H + H L+ + +LD + + F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG--VFLTGF 250 Query: 163 GYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ---EYD-------GKIADVWSCGVTLYVML 212 + V + + + PE+ R+ Y D W+ G+ +Y + Sbjct: 251 ---EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIW 307 Query: 213 VGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEI 272 P + + I L+ R+ + Sbjct: 308 CADLPITKDAALGGSEWIFRSCKN----------IPQPVRALLEGFLRYPKEDRLLPLQA 357 Query: 273 KTHS 276 Sbjct: 358 METP 361 >3DZO-A nrPDB Length = 413 Score = 43.3 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 33/265 (12%), Positives = 72/265 (27%), Gaps = 57/265 (21%) Query: 49 AVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVI-----------------LTPTHL 91 A+K ++ + + + R I N + + V + + L + Sbjct: 121 AIKQMKE-EVLRLRLLRGIKNQKQAK----VHLRFIFPFDLVKDPQKKKMIRVRLDERDM 175 Query: 92 AII--------ME--YASGGE-LYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 ++ M+ + GE L Q++ ++ H + H Sbjct: 176 WVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHT 235 Query: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE-----VLLRQEYD 195 L+ + +LD L G+ + S +G + PE +L ++ Sbjct: 236 YLRPVDIVLDQRGGVFLT----GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHH 290 Query: 196 ----GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 D W+ G+ +Y + P D + + I Sbjct: 291 PTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKN----------IPQPV 340 Query: 252 CHLISRIFVADPATRISIPEIKTHS 276 L+ R+ + Sbjct: 341 RALLEGFLRYPKEDRLLPLQAMETP 365 >4WWA-A nrPDB Length = 261 Score = 41.4 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 46/149 (30%), Gaps = 22/149 (14%) Query: 37 RLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIV------------RFKEV 84 L R K + + +KY + + + HR+L ++ + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 85 ILTPTHLAIIM--EYASGG----ELYERI--CNAGRFSEDEARFFFQQLLSGVSYCHSMQ 136 + + E GG L + + +S D +++ + H Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS-DLVATTLRKVGRQIGLLHWND 156 Query: 137 ICHRDLKLENTLLDGSPAP-RLKICDFGY 164 CH DL N +L A + DFG Sbjct: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >1TQM-A nrPDB Length = 282 Score = 37.2 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 46/159 (28%), Gaps = 36/159 (22%) Query: 24 FVKDIGSGN-----------FGVARLMRDKLTKELVAVKYIERGDKID---------ENV 63 K +G G FG + K+ K ++ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSA 151 Query: 64 QREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ 123 + E + L+ + + A++ME ELY ++ + Sbjct: 152 RNEFRALQKLQGLAVPKVYAW----EGNAVLMELIDAKELYRVRVEN---PDEVLDMILE 204 Query: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDF 162 ++ + H I H DL N L+ + I DF Sbjct: 205 EVAK---FYH-RGIVHGDLSQYNVLVSEEG---IWIIDF 236 >3Q60-A nrPDB Length = 371 Score = 35.6 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 53/164 (32%), Gaps = 8/164 (4%) Query: 121 FFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGT 180 QL+ + S + H +N + P RL + D S + ++ ++ Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFI--MPDGRLMLGD--VSALWKVGTRGPASSVP 254 Query: 181 PAYIAPEVLLRQEYDGKIA-DVWSCGVTLYVMLVGAYPFE--DPEEPRDYRKTIQRILSV 237 Y E L A + W G+++Y + PF P +++ R+ Sbjct: 255 VTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGT 314 Query: 238 K-YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 + + LI R D R+ E FL+ Sbjct: 315 DSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >5YK0-A nrPDB Length = 452 Score = 34.5 bits (78), Expect = 0.067, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 44/178 (24%), Gaps = 60/178 (33%) Query: 34 GVARLMRDKLTKELVAVKYIERGDKID-----ENVQREIINHRSL--------------- 73 G VAVK G + +QR + + L Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 74 -----------------------RHP-----NIVRFKEVILTPTHLAIIMEYASGGELYE 105 HP ++V +I E+ G + E Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVA-------SAPKVVIQEWIEGVPMAE 257 Query: 106 RICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFG 163 I + D +L + + H D N +L P R+ I DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFML--LPDGRMGIIDFG 311 >4BVU-A nrPDB Length = 211 Score = 34.1 bits (77), Expect = 0.090, Method: Composition-based stats. Identities = 23/149 (15%), Positives = 43/149 (28%), Gaps = 29/149 (19%) Query: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKE 83 K IG G+ + + + + + N EI+ Sbjct: 44 LGKLIGQGSTAEIFEDVNDSS-------ALYKKYDLIGNQYNEILEMAWQESE----LFN 92 Query: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEA----------RFFFQQLLSGVSYCH 133 +++++Y GG++Y R+ + + Q + + Sbjct: 93 AFY-GDEASVVIQY--GGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LN 145 Query: 134 SMQICHRDLKLENTLLDGSPAPRLKICDF 162 + I H DL N L D I DF Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPI-DF 173 >6G5I-z nrPDB Length = 568 Score = 33.7 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 48/144 (33%), Gaps = 29/144 (20%) Query: 44 TKELVAVKYIERGDKIDENVQREIINHRSLRH-------------------PNIVRFKEV 84 E A+K + + ++ + + RH N++R Sbjct: 201 NGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTA 260 Query: 85 ---ILTPTHL---AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS-MQI 137 P L ++M + ++ + + SE +AR + Q++ + + ++ Sbjct: 261 EIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARL 320 Query: 138 CHRDLKLENTLLDGSPAPRLKICD 161 H DL N L G + I D Sbjct: 321 VHADLSEFNMLYHG---GGVYIID 341 >4OTP-A nrPDB Length = 352 Score = 33.7 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 48/144 (33%), Gaps = 29/144 (20%) Query: 44 TKELVAVKYIERGDKIDENVQREIINHRSLRH-------------------PNIVRFKEV 84 E A+K + + ++ + + RH N++R Sbjct: 59 NGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTA 118 Query: 85 ---ILTPTHL---AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS-MQI 137 P L ++M + ++ + + SE +AR + Q++ + + ++ Sbjct: 119 EIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARL 178 Query: 138 CHRDLKLENTLLDGSPAPRLKICD 161 H DL N L G + I D Sbjct: 179 VHADLSEFNMLYHG---GGVYIID 199 >6EF6-A nrPDB Length = 354 Score = 32.5 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%), Gaps = 1/28 (3%) Query: 136 QICHRDLKLENTLLDGS-PAPRLKICDF 162 + H DL+L N L+D S P + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6G18-v nrPDB Length = 552 Score = 32.1 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 29/78 (37%), Gaps = 10/78 (12%) Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSE-DEARFFFQQLLSGVSYCHSMQICHRDLKL 144 + A++ME +G L + S DEA +L + + H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 145 ENTLLDGSPAPRLKICDF 162 N +LD S + + DF Sbjct: 232 FNLILDESD--HITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 31.4 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 29/78 (37%), Gaps = 10/78 (12%) Query: 86 LTPTHLAIIMEYASGGELYERICNAGRFSE-DEARFFFQQLLSGVSYCHSMQICHRDLKL 144 + A++ME +G L + S DEA +L + + H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 145 ENTLLDGSPAPRLKICDF 162 N +LD S + + DF Sbjct: 232 FNLILDESD--HITMIDF 247 >4H05-A nrPDB Length = 273 Score = 31.0 bits (69), Expect = 0.85, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 13/27 (48%) Query: 137 ICHRDLKLENTLLDGSPAPRLKICDFG 163 +CH DL +N LLD + D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >4GYG-A nrPDB Length = 397 Score = 29.4 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 24/78 (30%), Gaps = 14/78 (17%) Query: 93 IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--- 149 I+M L + + S + + L++ + + H D N L+ Sbjct: 188 IVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREE 241 Query: 150 -DGSPAPRLK----ICDF 162 D + I DF Sbjct: 242 KDAEDPSSITLTPIIIDF 259 >6QM4-A nrPDB Length = 735 Score = 29.1 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 23/47 (48%), Gaps = 2/47 (4%) Query: 51 KYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEY 97 K ++ G K+ E+ + E + +R +E ++ + ++M++ Sbjct: 467 KQLKSGSKVQEDHEEEAEFLQRVREE--CTLEEYDVSGDYREMVMQF 511 >2X8T-A nrPDB Length = 471 Score = 29.1 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 12/28 (42%) Query: 74 RHPNIVRFKEVILTPTHLAIIMEYASGG 101 +HPN+V L ++ SGG Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG 192 >2Y0O-A nrPDB Length = 175 Score = 28.7 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 20/44 (45%) Query: 147 TLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 +L ++++ D+G K + Q V T Y + E++L Sbjct: 17 IVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60 >6DFL-A nrPDB Length = 259 Score = 28.7 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 46/166 (27%), Gaps = 17/166 (10%) Query: 29 GSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRF------- 81 G G F ++ R E+ K + ++E R L + Sbjct: 45 GRGYF--VKIHRGIGWGEI--AKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGE 100 Query: 82 KEVILTPTHLAIIME-YASGGEL--YERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 + H I+ E A +L + + R + + V H + Sbjct: 101 RGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVN 160 Query: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 184 HRD + + LL + DF S LH + Sbjct: 161 HRDCYICHFLLHTDKP--VSADDFRLS-VIDLHRAQTRDATPKRWR 203 >5GO1-A nrPDB Length = 151 Score = 28.7 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 9/63 (14%), Positives = 27/63 (42%), Gaps = 5/63 (7%) Query: 34 GVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAI 93 G ++ +LVA+K ++ + E +++ + P +V++ + + + Sbjct: 21 GEVICRFERKGYKLVALKMLQPTTEQAEGHYKDLSSKPFF--PALVKY---FSSGPIVCM 75 Query: 94 IME 96 + E Sbjct: 76 VWE 78 >2UZK-A nrPDB Length = 97 Score = 28.3 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 17/31 (54%), Gaps = 2/31 (6%) Query: 253 HLISRIFVADPATRISIPEIKTHSWFLKNLP 283 LI+R + P R+++ +I W ++ +P Sbjct: 8 DLITRAIESSPDKRLTLSQIYE--WMVRCVP 36 >4FDJ-A nrPDB Length = 502 Score = 28.3 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 16/64 (25%), Gaps = 13/64 (20%) Query: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDT 308 E I R + + H +FL F Q + D Sbjct: 185 QEALDFIKR-------------QARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDA 231 Query: 309 IMQI 312 + +I Sbjct: 232 VREI 235 >4ESA-B nrPDB Length = 146 Score = 28.3 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%), Gaps = 5/50 (10%) Query: 31 GNFGVARLMRDKLTKELVA---VKYIERGDKIDENV--QREIINHRSLRH 75 G+FG + + VA +K + D+ +N+ +EI S+ H Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 >1XIQ-A nrPDB Length = 157 Score = 27.9 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 29/63 (46%), Gaps = 5/63 (7%) Query: 34 GVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAI 93 G +K +L+A+K + ++I + +E+ + + N+V + I +A+ Sbjct: 27 GTIIKRFEKKGYKLIAIKMLNPTEEILKEHYKELSDQPFFK--NLVAY---ISKGPVVAM 81 Query: 94 IME 96 + E Sbjct: 82 VWE 84 >6FAI-l nrPDB Length = 425 Score = 27.9 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 23/170 (13%), Positives = 47/170 (27%), Gaps = 39/170 (22%) Query: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKY-----------------IERGDK------ 58 Y IG G + DK V +K +++ ++ Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 59 -IDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDE 117 +E L + E H+ ++ME G + R+ Sbjct: 154 LSRLAANKEYQFMSMLYSKG-FKVPEPFDNSRHI-VVMELIEGYPMR-RLRKHKNIP--- 207 Query: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLL-----DGSPAPRLKICDF 162 + L+ + + + H D N ++ D + + + DF Sbjct: 208 --KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFV-VIDF 254 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.154 0.466 Lambda K H 0.267 0.0471 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,882,960 Number of Sequences: 36641 Number of extensions: 705770 Number of successful extensions: 6360 Number of sequences better than 10.0: 512 Number of HSP's better than 10.0 without gapping: 815 Number of HSP's successfully gapped in prelim test: 143 Number of HSP's that attempted gapping in prelim test: 2068 Number of HSP's gapped (non-prelim): 1079 length of query: 361 length of database: 10,336,785 effective HSP length: 98 effective length of query: 263 effective length of database: 6,745,967 effective search space: 1774189321 effective search space used: 1774189321 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.5 bits)