BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= Q39026 (395 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6DTL-A nrPDB 756 0.0 4IC8-A nrPDB 352 1e-97 5Z33-A nrPDB 351 4e-97 4ZSG-A nrPDB 350 5e-97 5NGU-A nrPDB 350 5e-97 2F9G-A nrPDB 344 3e-95 4QTB-A nrPDB 344 4e-95 3OHT-A nrPDB 337 5e-93 4EWQ-A nrPDB 331 4e-91 3GC9-A nrPDB 326 9e-90 4O2Z-A nrPDB 316 9e-87 4QNY-A nrPDB 310 5e-85 1CM8-A nrPDB 309 1e-84 4MYG-A nrPDB 308 4e-84 3RP9-A nrPDB 265 3e-71 1JNK-A nrPDB 263 7e-71 3E7O-A nrPDB 260 8e-70 3FI2-A nrPDB 260 8e-70 2XS0-A nrPDB 258 3e-69 5AWM-A nrPDB 256 1e-68 3OZ6-A nrPDB 248 4e-66 3N9X-A nrPDB 245 2e-65 3NIE-A nrPDB 241 5e-64 3PG1-A nrPDB 240 7e-64 2I6L-A nrPDB 237 5e-63 4AU8-A nrPDB 198 3e-51 3NIZ-A nrPDB 197 6e-51 2BPM-A nrPDB 195 2e-50 5G6V-A nrPDB 194 6e-50 6GU6-A nrPDB 193 9e-50 4AGU-A nrPDB 189 2e-48 1V0B-A nrPDB 188 3e-48 1G3N-A nrPDB 185 3e-47 5AIR-A nrPDB 184 5e-47 4NST-A nrPDB 184 6e-47 1UA2-A nrPDB 184 7e-47 4BBM-A nrPDB 183 1e-46 5EFQ-A nrPDB 181 4e-46 4KRC-A nrPDB 180 1e-45 4BGQ-A nrPDB 179 1e-45 3EB0-A nrPDB 177 5e-45 2W96-B nrPDB 177 8e-45 4E7W-A nrPDB 176 1e-44 3GC0-A nrPDB 165 3e-41 3MIA-A nrPDB 162 3e-40 3E3P-A nrPDB 157 1e-38 3ZDU-A nrPDB 154 7e-38 5Y86-A nrPDB 144 7e-35 4CRL-A nrPDB 140 1e-33 3NCG-A nrPDB 137 7e-33 3DFA-A nrPDB 136 2e-32 5ZTN-A nrPDB 135 4e-32 5JN2-A nrPDB 128 4e-30 2YCR-A nrPDB 128 4e-30 3I6U-A nrPDB 125 2e-29 3MA6-A nrPDB 125 3e-29 3LIJ-A nrPDB 122 2e-28 4IAN-A nrPDB 120 8e-28 4RGJ-A nrPDB 119 2e-27 2PVN-A nrPDB 117 8e-27 4MD7-E nrPDB 116 1e-26 5IG1-A nrPDB 115 2e-26 6EII-A nrPDB 115 3e-26 4MVF-A nrPDB 114 9e-26 6HMD-A nrPDB 113 1e-25 3H4J-B nrPDB 113 1e-25 2F57-A nrPDB 113 1e-25 3MN3-A nrPDB 113 2e-25 2V7O-A nrPDB 112 2e-25 6O6Q-A nrPDB 112 3e-25 3VN9-A nrPDB 112 3e-25 3BHH-A nrPDB 112 4e-25 5XVU-A nrPDB 110 7e-25 2BDW-A nrPDB 110 1e-24 2VN9-A nrPDB 110 1e-24 5FG8-A nrPDB 110 1e-24 5X8I-B nrPDB 109 2e-24 6FDY-U nrPDB 109 2e-24 5U6Y-A nrPDB 109 2e-24 2VZ6-A nrPDB 109 3e-24 3KK8-A nrPDB 108 4e-24 3HZT-A nrPDB 107 8e-24 3DXN-A nrPDB 107 8e-24 4YZB-A nrPDB 107 1e-23 6QAU-A nrPDB 106 2e-23 3RAW-A nrPDB 105 3e-23 2WO6-A nrPDB 105 4e-23 2W4O-A nrPDB 105 4e-23 4KS7-A nrPDB 105 4e-23 5YKS-A nrPDB 104 5e-23 5XZW-A nrPDB 104 5e-23 4LFI-A nrPDB 104 5e-23 3FME-A nrPDB 104 6e-23 3SOA-A nrPDB 104 6e-23 2OU7-A nrPDB 103 9e-23 2Y7J-A nrPDB 103 1e-22 6FYV-A nrPDB 103 1e-22 4CFH-A nrPDB 103 1e-22 4FIE-A nrPDB 103 2e-22 4REW-A nrPDB 102 2e-22 4B6L-A nrPDB 102 2e-22 6CMJ-A nrPDB 102 2e-22 3KN6-A nrPDB 102 3e-22 4JDH-A nrPDB 102 3e-22 4RED-A nrPDB 102 3e-22 4PDS-A nrPDB 102 3e-22 4J52-A nrPDB 102 3e-22 2JC6-A nrPDB 101 5e-22 2Q0N-A nrPDB 101 7e-22 3DB8-A nrPDB 100 8e-22 4XBR-A nrPDB 100 1e-21 4FG9-A nrPDB 100 1e-21 4CZT-A nrPDB 100 2e-21 3IS5-A nrPDB 99 2e-21 4CQG-A nrPDB 99 2e-21 4NIF-A nrPDB 99 3e-21 5J5T-A nrPDB 99 5e-21 1PHK-A nrPDB 99 5e-21 3F3Z-A nrPDB 98 6e-21 3COM-A nrPDB 98 7e-21 4WNO-A nrPDB 97 9e-21 4JG6-A nrPDB 97 1e-20 4D28-A nrPDB 97 1e-20 3Q5I-A nrPDB 97 1e-20 5YV8-A nrPDB 97 1e-20 5UNP-A nrPDB 96 3e-20 5JZN-A nrPDB 96 4e-20 2BRG-A nrPDB 96 4e-20 6E2O-A nrPDB 95 6e-20 2J90-A nrPDB 95 6e-20 4KIK-B nrPDB 95 6e-20 3GUB-A nrPDB 94 7e-20 4CFF-A nrPDB 94 1e-19 6CCF-A nrPDB 94 1e-19 3QA8-A nrPDB 94 1e-19 5EZV-A nrPDB 93 2e-19 5TQX-A nrPDB 93 2e-19 4LG4-A nrPDB 93 2e-19 5ES1-A nrPDB 93 2e-19 2QNJ-A nrPDB 93 3e-19 5WAX-A nrPDB 92 3e-19 1U5R-A nrPDB 92 3e-19 4D2V-A nrPDB 92 4e-19 1KOB-A nrPDB 92 4e-19 4C0T-A nrPDB 92 4e-19 1ZWS-A nrPDB 92 4e-19 3D2K-A nrPDB 92 4e-19 6AO5-A nrPDB 92 4e-19 4I6B-A nrPDB 92 5e-19 2A27-A nrPDB 92 5e-19 4UZD-A nrPDB 92 6e-19 2GCD-A nrPDB 91 6e-19 2XNP-A nrPDB 91 7e-19 4TNB-A nrPDB 91 9e-19 3TAC-A nrPDB 91 1e-18 5KZ7-A nrPDB 91 1e-18 2YZA-A nrPDB 91 1e-18 6C9D-A nrPDB 90 1e-18 4JXF-A nrPDB 90 2e-18 1ZXE-A nrPDB 90 2e-18 2YAB-A nrPDB 89 3e-18 4APC-A nrPDB 89 4e-18 6CQF-A nrPDB 89 4e-18 3ORZ-A nrPDB 89 5e-18 2HAK-A nrPDB 89 5e-18 3UC3-A nrPDB 88 6e-18 3KA0-A nrPDB 88 6e-18 2JAM-A nrPDB 87 9e-18 4OW8-A nrPDB 87 1e-17 4X3F-A nrPDB 87 1e-17 6B2Q-A nrPDB 87 1e-17 3ZUT-A nrPDB 87 2e-17 6FD3-A nrPDB 86 2e-17 3Q53-A nrPDB 86 3e-17 5D9K-A nrPDB 86 3e-17 2JDO-A nrPDB 86 3e-17 3UDB-A nrPDB 86 4e-17 2OZA-A nrPDB 85 4e-17 1NY3-A nrPDB 85 4e-17 2UV2-A nrPDB 85 6e-17 2XIK-A nrPDB 85 6e-17 2X4F-A nrPDB 84 8e-17 1S9I-A nrPDB 84 8e-17 4FR4-A nrPDB 84 9e-17 4B8L-A nrPDB 84 1e-16 2Z7Q-A nrPDB 84 1e-16 4EQM-A nrPDB 84 1e-16 2WQN-A nrPDB 83 2e-16 3DLS-A nrPDB 83 2e-16 3LM0-A nrPDB 83 2e-16 4GS6-A nrPDB 83 2e-16 5KCV-A nrPDB 82 3e-16 4YNZ-A nrPDB 82 3e-16 3MV5-A nrPDB 82 3e-16 6BDL-A nrPDB 82 5e-16 3UTO-A nrPDB 82 6e-16 5H2U-A nrPDB 81 7e-16 5D7A-A nrPDB 81 8e-16 1KOA-A nrPDB 81 8e-16 4M7I-A nrPDB 81 9e-16 3HKO-A nrPDB 80 1e-15 3ALO-A nrPDB 80 1e-15 5LOH-A nrPDB 80 1e-15 1VZO-A nrPDB 80 1e-15 4QMW-A nrPDB 80 1e-15 5HVK-A nrPDB 80 1e-15 2A1A-B nrPDB 80 2e-15 6GQK-A nrPDB 80 2e-15 4FZF-B nrPDB 80 2e-15 5FET-A nrPDB 80 2e-15 5F9E-A nrPDB 80 2e-15 4PWN-A nrPDB 79 3e-15 4L42-A nrPDB 79 3e-15 4P5Q-A nrPDB 79 3e-15 1JPA-A nrPDB 79 3e-15 5O0Y-A nrPDB 79 4e-15 4RLP-A nrPDB 79 4e-15 3FXW-A nrPDB 79 4e-15 4AF3-A nrPDB 79 5e-15 3PLS-A nrPDB 79 5e-15 3UIU-A nrPDB 79 5e-15 2WTK-C nrPDB 78 5e-15 5DYK-A nrPDB 78 6e-15 5N23-A nrPDB 78 7e-15 5KKR-C nrPDB 78 7e-15 6HXF-B nrPDB 78 7e-15 4WB7-A nrPDB 78 9e-15 3DKO-A nrPDB 77 9e-15 3EQC-A nrPDB 77 1e-14 2RIO-A nrPDB 77 1e-14 4IDT-A nrPDB 77 2e-14 3LLT-A nrPDB 77 2e-14 3NYO-A nrPDB 76 2e-14 4YHJ-A nrPDB 76 2e-14 4AN9-A nrPDB 76 2e-14 3IO7-A nrPDB 76 2e-14 2W1I-A nrPDB 76 2e-14 2HK5-A nrPDB 76 2e-14 3HDN-A nrPDB 76 2e-14 5B2L-A nrPDB 76 3e-14 3DAK-A nrPDB 76 3e-14 2PMN-X nrPDB 76 3e-14 3PPZ-A nrPDB 76 3e-14 5DBX-A nrPDB 75 3e-14 2Y6O-A nrPDB 75 3e-14 2JD5-A nrPDB 75 3e-14 4RA4-A nrPDB 75 4e-14 5X5O-A nrPDB 75 4e-14 5X3F-B nrPDB 75 4e-14 4PDO-A nrPDB 75 5e-14 6DBN-A nrPDB 75 5e-14 4WUA-A nrPDB 75 6e-14 4PL5-B nrPDB 75 7e-14 1FOT-A nrPDB 74 8e-14 5TUR-A nrPDB 74 8e-14 5O2C-A nrPDB 74 9e-14 5O2B-A nrPDB 74 9e-14 3A8W-A nrPDB 74 1e-13 3C51-A nrPDB 74 1e-13 2R2P-A nrPDB 74 1e-13 5UUU-A nrPDB 74 1e-13 4RC3-A nrPDB 74 1e-13 6HV0-A nrPDB 74 1e-13 3BGP-A nrPDB 74 2e-13 6CTH-A nrPDB 73 2e-13 3PVW-A nrPDB 73 2e-13 2X7G-A nrPDB 73 2e-13 1AD5-A nrPDB 73 2e-13 4U41-A nrPDB 73 2e-13 3CJF-A nrPDB 73 2e-13 4G3E-A nrPDB 73 3e-13 5MJB-A nrPDB 73 3e-13 5VO2-A nrPDB 72 3e-13 2VWV-A nrPDB 72 3e-13 4E20-A nrPDB 72 4e-13 5L6P-A nrPDB 72 4e-13 6DBM-A nrPDB 72 6e-13 5GRN-A nrPDB 72 6e-13 5VD3-A nrPDB 71 8e-13 5EG3-A nrPDB 71 8e-13 5X02-A nrPDB 70 1e-12 4E93-A nrPDB 70 1e-12 2DQ7-X nrPDB 70 2e-12 4HVI-A nrPDB 70 2e-12 4XUF-A nrPDB 70 2e-12 2H8H-A nrPDB 70 2e-12 3QD2-B nrPDB 70 2e-12 2I0E-A nrPDB 70 2e-12 4CSV-A nrPDB 70 2e-12 6CKI-A nrPDB 70 2e-12 4UY9-A nrPDB 69 3e-12 3PFQ-A nrPDB 69 3e-12 3ORP-A nrPDB 69 3e-12 3DTC-A nrPDB 69 4e-12 4OLI-A nrPDB 69 4e-12 6F3F-A nrPDB 69 4e-12 4TPT-A nrPDB 69 4e-12 5SYS-A nrPDB 69 4e-12 3A4O-X nrPDB 69 5e-12 3M42-A nrPDB 68 5e-12 4EBW-A nrPDB 68 6e-12 5HLW-A nrPDB 68 6e-12 2HW6-A nrPDB 68 8e-12 4F9B-A nrPDB 68 8e-12 6NPU-A nrPDB 68 9e-12 3KUL-B nrPDB 67 9e-12 4XEY-B nrPDB 67 1e-11 4XCU-A nrPDB 67 1e-11 4AT3-A nrPDB 67 1e-11 3C1X-A nrPDB 67 1e-11 6J5U-C nrPDB 67 1e-11 2XYN-A nrPDB 67 1e-11 4UYA-A nrPDB 67 2e-11 2J0K-A nrPDB 67 2e-11 1TKI-A nrPDB 66 2e-11 3BEA-A nrPDB 66 2e-11 2FO0-A nrPDB 66 2e-11 5UIU-A nrPDB 66 3e-11 4AW2-A nrPDB 66 3e-11 6ED6-A nrPDB 66 3e-11 6GVJ-A nrPDB 65 3e-11 2PL0-A nrPDB 65 4e-11 3G0E-A nrPDB 65 4e-11 4K33-A nrPDB 65 4e-11 6FER-A nrPDB 65 5e-11 5AP3-A nrPDB 65 5e-11 6BXI-A nrPDB 65 6e-11 3TXO-A nrPDB 65 6e-11 5LPZ-A nrPDB 65 6e-11 2PSQ-A nrPDB 65 7e-11 5LPV-A nrPDB 65 7e-11 5XD6-A nrPDB 64 8e-11 3HMP-A nrPDB 64 8e-11 4C59-A nrPDB 64 9e-11 3V5Q-A nrPDB 64 1e-10 3VHK-A nrPDB 64 1e-10 5HI2-A nrPDB 64 1e-10 6E9W-A nrPDB 64 2e-10 4H1J-A nrPDB 63 2e-10 5U6B-A nrPDB 63 2e-10 3GQL-A nrPDB 63 2e-10 3TT0-A nrPDB 63 2e-10 3QUP-A nrPDB 63 3e-10 2ZMD-A nrPDB 63 3e-10 3KRL-A nrPDB 63 3e-10 5A46-A nrPDB 62 3e-10 3HNG-A nrPDB 62 4e-10 4RT7-A nrPDB 62 4e-10 4YFF-A nrPDB 62 5e-10 3TKU-A nrPDB 62 5e-10 5TOS-A nrPDB 62 6e-10 2OGV-A nrPDB 62 6e-10 2OZO-A nrPDB 62 6e-10 2H34-A nrPDB 61 7e-10 4CRS-A nrPDB 61 8e-10 1U59-A nrPDB 61 8e-10 1U54-B nrPDB 61 8e-10 1K9A-A nrPDB 61 8e-10 1BYG-A nrPDB 61 9e-10 4R7H-A nrPDB 61 9e-10 3OMV-A nrPDB 61 1e-09 4HZS-A nrPDB 60 1e-09 5HIE-A nrPDB 60 2e-09 4FL3-A nrPDB 60 2e-09 2BUJ-A nrPDB 60 2e-09 4M66-A nrPDB 60 2e-09 3QGY-A nrPDB 59 3e-09 4XI2-A nrPDB 59 4e-09 1LUF-A nrPDB 59 4e-09 3LMG-A nrPDB 59 4e-09 4X7Q-B nrPDB 59 4e-09 5C26-A nrPDB 59 4e-09 6BSD-A nrPDB 59 5e-09 6E4F-A nrPDB 59 5e-09 5GNK-A nrPDB 58 9e-09 6O8B-A nrPDB 58 9e-09 3LZB-A nrPDB 57 1e-08 2Y4I-B nrPDB 57 1e-08 5TE0-A nrPDB 57 1e-08 4OTD-A nrPDB 57 1e-08 4EUT-A nrPDB 57 1e-08 4EUU-A nrPDB 57 1e-08 4Y93-A nrPDB 57 2e-08 4JLC-A nrPDB 57 2e-08 3I81-A nrPDB 57 2e-08 3BBT-B nrPDB 57 2e-08 6FEX-A nrPDB 57 2e-08 5FM2-A nrPDB 56 2e-08 5AMN-A nrPDB 56 2e-08 4Y83-A nrPDB 56 2e-08 4XLV-A nrPDB 56 3e-08 6NT9-A nrPDB 56 3e-08 4LRM-A nrPDB 55 4e-08 3ZZW-A nrPDB 55 4e-08 1FVR-A nrPDB 55 5e-08 3PP0-A nrPDB 55 6e-08 3Q4U-A nrPDB 55 6e-08 5L2Q-C nrPDB 55 7e-08 4LQP-A nrPDB 54 9e-08 6BFN-A nrPDB 54 1e-07 3SXS-A nrPDB 54 1e-07 3UIM-A nrPDB 54 1e-07 5IKW-A nrPDB 53 2e-07 5U6C-A nrPDB 53 2e-07 4Y12-A nrPDB 53 2e-07 5KMM-A nrPDB 53 3e-07 2QKW-B nrPDB 53 3e-07 4BTK-A nrPDB 53 3e-07 4NFN-A nrPDB 53 3e-07 5WNO-A nrPDB 52 3e-07 3G2F-A nrPDB 52 4e-07 2PZI-A nrPDB 52 6e-07 3SOC-A nrPDB 51 7e-07 5WNL-A nrPDB 51 7e-07 5CEK-A nrPDB 51 8e-07 5J0A-A nrPDB 51 8e-07 4F0G-A nrPDB 51 1e-06 6DC0-A nrPDB 50 1e-06 4NEU-A nrPDB 50 1e-06 5FQD-C nrPDB 50 2e-06 3ZBF-A nrPDB 49 3e-06 3SV0-A nrPDB 49 3e-06 2VD5-A nrPDB 49 4e-06 5AR8-A nrPDB 48 7e-06 3MDY-A nrPDB 48 9e-06 4L68-A nrPDB 47 2e-05 3MY0-A nrPDB 46 3e-05 5VC6-A nrPDB 46 4e-05 2QLU-A nrPDB 45 4e-05 5E8V-A nrPDB 44 1e-04 4M69-B nrPDB 44 1e-04 4BTF-A nrPDB 43 2e-04 4JRN-A nrPDB 43 2e-04 2WTK-B nrPDB 42 4e-04 2CMW-A nrPDB 42 5e-04 5VDK-A nrPDB 41 0.001 4TN6-A nrPDB 40 0.001 1PY5-A nrPDB 40 0.001 5CLR-A nrPDB 39 0.003 5M07-A nrPDB 38 0.006 2RSV-A nrPDB 38 0.006 4NT4-A nrPDB 38 0.008 4L00-A nrPDB 38 0.009 2LAV-A nrPDB 38 0.009 5X1R-A nrPDB 37 0.011 4XHL-A nrPDB 37 0.012 4XHH-A nrPDB 37 0.016 6J6I-B nrPDB 37 0.017 2CHL-A nrPDB 37 0.017 1CSN-A nrPDB 37 0.017 2C47-A nrPDB 36 0.022 4IX6-A nrPDB 35 0.042 5UV4-A nrPDB 35 0.075 3ENH-A nrPDB 35 0.081 5UU1-A nrPDB 34 0.12 5UQL-A nrPDB 34 0.13 5OAT-A nrPDB 33 0.17 6G4J-A nrPDB 33 0.22 4CI6-B nrPDB 32 0.59 4AZV-A nrPDB 31 0.91 2KC5-A nrPDB 31 0.96 6FRK-r nrPDB 31 1.1 4AZW-A nrPDB 31 1.1 5X18-A nrPDB 30 1.2 6EWX-A nrPDB 30 1.3 5VE6-A nrPDB 30 1.4 5BX9-A nrPDB 30 1.7 5WRW-A nrPDB 30 1.8 4O1O-A nrPDB 30 2.7 5USZ-A nrPDB 28 6.5 6EQI-C nrPDB 28 8.3 4OAU-C nrPDB 28 9.9 >6DTL-A nrPDB Length = 364 Score = 756 bits (1951), Expect = 0.0, Method: Compositional matrix adjust. Identities = 364/364 (100%), Positives = 364/364 (100%) Query: 32 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 91 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI Sbjct: 1 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 60 Query: 92 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 151 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL Sbjct: 61 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 120 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 211 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA Sbjct: 121 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 180 Query: 212 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH Sbjct: 181 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 240 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF Sbjct: 241 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 300 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP Sbjct: 301 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 Query: 392 EYQQ 395 EYQQ Sbjct: 361 EYQQ 364 >4IC8-A nrPDB Length = 442 Score = 352 bits (904), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 179/352 (50%), Positives = 243/352 (69%), Gaps = 8/352 (2%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 ++ F F+V +Y+ I IG GAYG+V SA T + VAIKKI NAFD +AK Sbjct: 41 LLKARSFDVTFDVGDEYEI-IETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAK 99 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPL-RNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 RTLRE+K+L+H H+NI+AI+DI+ P + F VY+ +LM++DLHQII S+Q L+ E Sbjct: 100 RTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLE 159 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR--VTSESD---F 219 H +YFLYQ+LRGLKY+HSA V+HRDLKPSNLL+N NC+LKI DFG+AR TS ++ F Sbjct: 160 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYF 219 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 MTEYV TRWYRAPEL+L+ +YT AID+WSVGCIF E++ R+ LFPG+++VHQL+L+M + Sbjct: 220 MTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMV 279 Query: 280 IGTPSEEELEFLN-ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 +GTPS ++ + E + YI+ LPP +P A+ L+ +ML F+P RI+ Sbjct: 280 LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARIS 339 Query: 339 VLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 AL HP+L HD DEP+C PF+F F+ AL+ E++KE I E F+ Sbjct: 340 AAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 391 >5Z33-A nrPDB Length = 425 Score = 351 bits (900), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 186/356 (52%), Positives = 242/356 (67%), Gaps = 17/356 (4%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 GR I + +F F V +Y +G+GAYGIVC+A+N++T+E VAIKK+ N F KI Sbjct: 16 GRKI-FKVFNQDFIVDERYTV-TKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKIL 73 Query: 104 AKRTLREIKLLRHM-DHENIVAIRDI-IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL 161 AKR LREIKLL+H H NI + D+ IP P + FN+ Y+ ELM+ DL IIRS Q L Sbjct: 74 AKRALREIKLLQHFRGHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPL 131 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-----E 216 ++ H Q F+YQIL GLKYIHSANVLHRDLKP NLL+NA+C+LKICDFGLAR S Sbjct: 132 TDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEEN 191 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 + +MTEYV TRWYRAPE++L+ YT AIDVWSVGCI EL+ +P F GRD+V QL + Sbjct: 192 AGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQI 251 Query: 277 MELIGTPSEEELEFLNE-NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 + ++GTP+EE L + A+ Y+R LP ++ FP +P A+DL+++ML FDP Sbjct: 252 LHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSS 311 Query: 336 RITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEE--QMKELIYREALAF 389 RI+V AL HPYL+ HD SDEP+C FNFDFE + E+ +M+++I E F Sbjct: 312 RISVEQALEHPYLHIWHDASDEPDCPTTFNFDFE---VVEDVGEMRKMILDEVYRF 364 >4ZSG-A nrPDB Length = 347 Score = 350 bits (899), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 178/342 (52%), Positives = 240/342 (70%), Gaps = 8/342 (2%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+V +Y+ I IG GAYG+V SA T + VAIKKI NAFD +AKRTLRE+K+L+ Sbjct: 3 FDVGDEYEI-IETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 61 Query: 116 HMDHENIVAIRDIIPPPL-RNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQIL 174 H H+NI+AI+DI+ P + F VY+ +LM++DLHQII S+Q L+ EH +YFLYQ+L Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR--VTSESD---FMTEYVVTRWY 229 RGLKY+HSA V+HRDLKPSNLL+N NC+LKI DFG+AR TS ++ FMTEYV TRWY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 RAPEL+L+ +YT AID+WSVGCIF E++ R+ LFPG+++VHQL+L+M ++GTPS ++ Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 290 FLN-ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + E + YI+ LPP +P A+ L+ +ML F+P RI+ AL HP+L Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 Query: 349 NSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 HD DEP+C PF+F F+ AL+ E++KE I E F+ Sbjct: 302 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 343 >5NGU-A nrPDB Length = 381 Score = 350 bits (898), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 179/349 (51%), Positives = 239/349 (68%), Gaps = 8/349 (2%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 + G +F+V +Y + IG+GAYG+VCSA ++ VAIKKI+ F+++ +RTLRE Sbjct: 33 VRGQVFDVGPRYTN-LSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLRE 90 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 IK+L HENI+ I DII P DVYI +LM+TDL++++++ Q LS +H YFL Sbjct: 91 IKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFL 149 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----SESDFMTEYVVT 226 YQILRGLKYIHSANVLHRDLKPSNLLLN CDLKICDFGLARV + F+TEYV T Sbjct: 150 YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVAT 209 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 RWYRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+E Sbjct: 210 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 269 Query: 287 ELE-FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +L +N A+ Y+ LP + FP A+DL++KMLTF+P +RI V ALAH Sbjct: 270 DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 329 Query: 346 PYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 PYL +D SDEP PF FD E L +E++KELI+ E F P Y+ Sbjct: 330 PYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 378 >2F9G-A nrPDB Length = 353 Score = 344 bits (883), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 178/337 (52%), Positives = 231/337 (68%), Gaps = 19/337 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+GAYG+VCSA + T E VAIKKI FD + A RTLREIK+L+H HENI+ I +I Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 P FN+VYI ELM TDLH++I S Q LS++H QYF+YQ LR +K +H +NV+HR Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSES-----------DFMTEYVVTRWYRAPELLLN 237 DLKPSNLL+N+NCDLK+CDFGLAR+ ES MTEYV TRWYRAPE++L Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP-SEEELEFLNE-NA 295 S+ Y+ A+DVWS GCI EL R+P+FPGRD+ HQL L+ +IGTP S+ +L + A Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 + YI+ LP YP + FP V+P IDL+++ML FDP +RIT +AL HPYL + HD + Sbjct: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 Query: 356 DEPECT-IP---FNFDFENHALSEEQMKELIYREALA 388 DEPE IP F FD AL+ + +K+LI+ E + Sbjct: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4QTB-A nrPDB Length = 380 Score = 344 bits (883), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 172/346 (49%), Positives = 239/346 (69%), Gaps = 8/346 (2%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 + G F+V +Y + IG+GAYG+V SA + VAIKKI+ F+++ +RTLRE Sbjct: 32 VKGQPFDVGPRYTQ-LQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLRE 89 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 I++L HEN++ IRDI+ A DVYI +LM+TDL+++++S Q LS +H YFL Sbjct: 90 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFL 148 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----SESDFMTEYVVT 226 YQILRGLKYIHSANVLHRDLKPSNLL+N CDLKICDFGLAR+ + F+TEYV T Sbjct: 149 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 208 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 RWYRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+E Sbjct: 209 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 268 Query: 287 ELE-FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +L +N A+ Y++ LP + + FP A+DL+++MLTF+P +RITV +ALAH Sbjct: 269 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 328 Query: 346 PYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 PYL +D +DEP PF F E L +E++KELI++E F P Sbjct: 329 PYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 374 >3OHT-A nrPDB Length = 389 Score = 337 bits (864), Expect = 5e-93, Method: Compositional matrix adjust. Identities = 169/362 (46%), Positives = 236/362 (65%), Gaps = 9/362 (2%) Query: 32 GIENIPATLSHGGR--FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV 89 G P T+SH R F + + I+EV +Y+ + P+G GAYG VCS+ + ++ + Sbjct: 21 GSAAAPFTMSHKERPTFYRQELNKTIWEVPERYQT-LSPVGSGAYGSVCSSYDVKSGLKI 79 Query: 90 AIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMD 148 A+KK++ F + I AKRT RE++LL+HM HEN++ + D+ P FNDVY+ LM Sbjct: 80 AVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMG 139 Query: 149 TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 208 DL+ I++ Q L+++H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI DF Sbjct: 140 ADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 198 Query: 209 GLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 GLAR T D MT YV TRWYRAPE++LN Y +D+WSVGCI EL+ + LFPG D Sbjct: 199 GLARHTD--DEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTD 256 Query: 269 HVHQLRLLMELIGTPSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 H++QL+ +M L GTP + + + A+ YI LP P+++ D F +PLA+DL+EK Sbjct: 257 HINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEK 316 Query: 328 MLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREAL 387 ML D +RIT +ALAHPY + HD DEPE P++ FE+ L E+ K L Y E Sbjct: 317 MLVLDTDKRITASEALAHPYFSQYHDPDDEPESE-PYDQSFESRQLEIEEWKRLTYEEVC 375 Query: 388 AF 389 +F Sbjct: 376 SF 377 >4EWQ-A nrPDB Length = 383 Score = 331 bits (848), Expect = 4e-91, Method: Compositional matrix adjust. Identities = 164/348 (47%), Positives = 232/348 (66%), Gaps = 7/348 (2%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F + + I+EV +Y+ + P+G GAYG VC+A +++T VA+KK++ F + I AK Sbjct: 31 FYRQELNKTIWEVPERYQN-LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 89 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 RT RE++LL+HM HEN++ + D+ P FNDVY+ LM DL+ I++ Q L+++ Sbjct: 90 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDD 148 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 224 H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI DFGLAR T D MT YV Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD--DEMTGYV 206 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 TRWYRAPE++LN Y +D+WSVGCI EL+ + LFPG DH+ QL+L++ L+GTP Sbjct: 207 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 266 Query: 285 EEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 E L+ + +E+A+ YI+ L P+ + + F +PLA+DL+EKML D +RIT AL Sbjct: 267 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 326 Query: 344 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 AH Y HD DEP P++ FE+ L ++ K L Y E ++F P Sbjct: 327 AHAYFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISFVP 373 >3GC9-A nrPDB Length = 370 Score = 326 bits (836), Expect = 9e-90, Method: Compositional matrix adjust. Identities = 158/346 (45%), Positives = 233/346 (67%), Gaps = 7/346 (2%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F + + ++EV + + + P+G GAYG VCSA ++ + VA+KK++ F + I A+ Sbjct: 14 FYRQELNKTVWEVPQRLQG-LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR 72 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 RT RE++LL+H+ HEN++ + D+ P F++VY+ LM DL+ I++S QALS+E Sbjct: 73 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS-QALSDE 131 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 224 H Q+ +YQ+LRGLKYIHSA ++HRDLKPSN+ +N + +L+I DFGLAR E MT YV Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE--MTGYV 189 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 TRWYRAPE++LN Y +D+WSVGCI EL+ K LFPG D++ QL+ +ME++GTPS Sbjct: 190 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPS 249 Query: 285 EEEL-EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 E L + +E+A+ YI+ LPP P++ ++ F +PLAIDL+ +ML D +R++ +AL Sbjct: 250 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 309 Query: 344 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAF 389 AH Y + HD DEPE P++ E + E+ KEL Y+E L+F Sbjct: 310 AHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSF 354 >4O2Z-A nrPDB Length = 377 Score = 316 bits (810), Expect = 9e-87, Method: Compositional matrix adjust. Identities = 164/359 (45%), Positives = 228/359 (63%), Gaps = 21/359 (5%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 G F YN+ G+ FEV +KY + +G GAYGI CS ++ +T E V+IKK + F + D Sbjct: 29 GDFKVYNVSGSPFEVPSKYTL-LKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVED 87 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLR--NAFNDVYIAYELMDTDLHQIIRSNQAL 161 KR LREI ++R HEN++ + +I+PP R ++F DVY+ LMD D++ ++RS Q L Sbjct: 88 GKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVL 147 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFM 220 E H QYF+YQILRGLKY+HSANV HRDLKP+NL+ N +C+LKI DFGL+R V + Sbjct: 148 EESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSEL 207 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 T+YV+TRWYR PELLL +++Y+ A+D+WSVGCIF E+ +RKP+FPGR+ + QLR++ + I Sbjct: 208 TDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHI 267 Query: 281 GTP------SEEELEFLNE--NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 G P E LE LNE + I +L P + ID + KM T D Sbjct: 268 GKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTE---------GIDFLSKMWTLD 318 Query: 333 PRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 P +R T D LAHPYL LHD DEP C PF + E+ + +++ + + + +NP Sbjct: 319 PSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >4QNY-A nrPDB Length = 354 Score = 310 bits (795), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 151/328 (46%), Positives = 223/328 (67%), Gaps = 5/328 (1%) Query: 69 IGKGAYGIVCSAMNSET-NESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG G+YG+V A ++++ N VA+K++ F+ I AKR LREIKLL H + +NI+ +R Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I+ P F+ YI ++M+TDL Q++RS Q L+E H Q+F+YQ LR L IHSA V+ Sbjct: 88 NILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVI 147 Query: 187 HRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRD+ P+N+L+N NCDLKICDFGLA+ + ++MT+YV RWYRAPEL++ DY+A I Sbjct: 148 HRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQI 207 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN-AKRYIRQLPP 304 DVW +GCI EL+ +PLF G+D V+QL ++++IGTPSEE++ + + A++Y+++ Sbjct: 208 DVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSH 267 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 P+ ++PT P A+DL+ ML F+P+RRITVL A+ HP+L LHD +D+ F Sbjct: 268 RPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDADDNLSYALF 327 Query: 365 NFDFENHALSEEQMKELIYREALAFNPE 392 FD EN + +K IY E++ F+ E Sbjct: 328 RFD-ENEQKTIVDVKRAIYEESVKFHNE 354 >1CM8-A nrPDB Length = 367 Score = 309 bits (791), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 150/351 (42%), Positives = 225/351 (64%), Gaps = 7/351 (1%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F + + +EV A Y+ + P+G GAYG VCSA++ T VAIKK+ F +++ AK Sbjct: 11 FYRQEVTKTAWEVRAVYRD-LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 R RE++LL+HM HEN++ + D+ P + F D Y+ M TDL ++++ ++ L E+ Sbjct: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK-HEKLGED 128 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 224 Q+ +YQ+L+GL+YIH+A ++HRDLKP NL +N +C+LKI DFGLAR MT YV Sbjct: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 VTRWYRAPE++LN YT +D+WSVGCI E++ K LF G DH+ QL+ +M++ GTP Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 Query: 285 EEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 E ++ L ++ AK Y++ LP ++ PLA++L+EKML D +R+T +AL Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 Query: 344 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 AHPY SLHD DEP+ ++ F++ + ++ K + Y+E L+F P Q Sbjct: 307 AHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 >4MYG-A nrPDB Length = 372 Score = 308 bits (788), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 156/349 (44%), Positives = 218/349 (62%), Gaps = 9/349 (2%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F + ++ +E+ Y P +G GAYG VCSA++ + E VAIKK++ F ++I AK Sbjct: 29 FYKQDVNKTAWELPKTYVSPTH-VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAK 87 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPP--PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 R RE+ LL+HM HEN++ + D+ P LRN F D Y+ M TDL +I+ SE Sbjct: 88 RAYRELLLLKHMQHENVIGLLDVFTPASSLRN-FYDFYLVMPFMQTDLQKIM--GMEFSE 144 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 E QY +YQ+L+GLKYIHSA V+HRDLKP NL +N +C+LKI DFGLAR MT Y Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGY 202 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 VVTRWYRAPE++L+ Y +D+WSVGCI E++ K LF G+D++ QL ++++ G P Sbjct: 203 VVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP 262 Query: 284 SEEELEFLNEN-AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 E ++ LN+ AK YI+ LP PR+ T FP P A DL+EKML D +R+T A Sbjct: 263 GTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQA 322 Query: 343 LAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 L HP+ D +E E PF+ E+ L+ ++ K+ IY+E + F+P Sbjct: 323 LTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >3RP9-A nrPDB Length = 458 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 150/390 (38%), Positives = 216/390 (55%), Gaps = 67/390 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G+YG VC A + VAIKKI F++ ID KR LREI +L ++H+++V + DI Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 + P F+++Y+ E+ D+D ++ R+ L+E H + LY +L G+KY+HSA +LHR Sbjct: 121 VIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHR 180 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTS--------------ESDF--------------M 220 DLKP+N L+N +C +K+CDFGLAR E D + Sbjct: 181 DLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQL 240 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM-----------DRKPLFPG--- 266 T +VVTRWYRAPEL+L +YT AIDVWS+GCIF EL+ DR PLFPG Sbjct: 241 TGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSC 300 Query: 267 -----------------RDHVHQLRLLMELIGTPSEEELEFL-NENAKRYIRQLPPYPRQ 308 R + QL ++ ++GTPSEE++E L E+AKRYIR P Sbjct: 301 FPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGT 360 Query: 309 SITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT----IPF 364 + ++FP AI L+++ML F+P +RIT+ + LAHP+ + E T +PF Sbjct: 361 DLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPF 420 Query: 365 NFDFENHALSEEQMKELIYREALAFNPEYQ 394 N D+ N + E Q++ +E ++PE Q Sbjct: 421 N-DWMN--MDEPQLRYAFVKEIQRYHPEIQ 447 >1JNK-A nrPDB Length = 423 Score = 263 bits (673), Expect = 7e-71, Method: Compositional matrix adjust. Identities = 145/358 (40%), Positives = 216/358 (60%), Gaps = 20/358 (5%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ A Sbjct: 47 QFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 KR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDH 163 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Y Sbjct: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 223 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 VVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +GTP Sbjct: 224 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFP-TVHPL-----------AIDLIEKMLTF 331 E ++ L + Y+ P Y + FP ++ P A DL+ KML Sbjct: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFD--FENHALSEEQMKELIYREAL 387 DP +RI+V DAL HPY+N +D + E E P +D + + E+ KELIY+E + Sbjct: 343 DPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 >3E7O-A nrPDB Length = 360 Score = 260 bits (664), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 144/359 (40%), Positives = 213/359 (59%), Gaps = 20/359 (5%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 +F + + F V +Y+ + PIG GA GIVC+A ++ +VA+KK++ F N+ Sbjct: 6 SQFYSVQVADSTFTVLKRYQQ-LKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH 64 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALS 162 AKR RE+ LL+ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I + L Sbjct: 65 AKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMELD 122 Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE 222 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S + MT Sbjct: 123 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTP 182 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 YVVTR+YRAPE++L Y +D+WSVGCI EL+ +F G DH+ Q ++E +GT Sbjct: 183 YVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGT 241 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFP-TVHP-----------LAIDLIEKMLT 330 PS E + L + Y+ P YP + + FP + P A DL+ KML Sbjct: 242 PSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLV 301 Query: 331 FDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFD--FENHALSEEQMKELIYREAL 387 DP +RI+V +AL HPY+ +D + E E P +D E + E+ KELIY+E + Sbjct: 302 IDPDKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 >3FI2-A nrPDB Length = 353 Score = 260 bits (664), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 145/359 (40%), Positives = 212/359 (59%), Gaps = 33/359 (9%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ A Sbjct: 9 QFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 67 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 KR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 68 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDH 125 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Y Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 VVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +GTP Sbjct: 186 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 244 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFP-TVHPL-----------AIDLIEKMLTF 331 E ++ L + Y+ P Y + FP ++ P A DL+ KML Sbjct: 245 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 304 Query: 332 DPRRRITVLDALAHPYLNSLH---DISDEPECTIPFNFDFENHALSEEQMKELIYREAL 387 DP +RI+V DAL HPY+N + DE E TI E+ KELIY+E + Sbjct: 305 DPAKRISVDDALQHPYINVWYXXXXXXDEREHTI-------------EEWKELIYKEVM 350 >2XS0-A nrPDB Length = 386 Score = 258 bits (659), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 145/358 (40%), Positives = 207/358 (57%), Gaps = 22/358 (6%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F I + F V +Y+ + PIG GA GIVC+A ++ +VAIKK++ F N+ AK Sbjct: 12 FYSVEIGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAK 70 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 R RE+ L++ ++H+NI+ + ++ P F DVYI ELMD +L Q+I+ L E Sbjct: 71 RAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ--MELDHE 128 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 224 Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S M +V Sbjct: 129 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFV 188 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 VTR+YRAPE++L Y +D+WSVGCI E++ LFPG DH+ Q ++E +GTP Sbjct: 189 VTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 247 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTV------------HPLAIDLIEKMLTFD 332 E ++ L + Y+ P Y S FP V A DL+ KML D Sbjct: 248 PEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVID 307 Query: 333 PRRRITVLDALAHPYLNSLHDIS--DEPECTIP-FNFDFENHALSEEQMKELIYREAL 387 +RI+V +AL HPY+N +D S + P IP D H + E+ KELIY+E + Sbjct: 308 ASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTI--EEWKELIYKEVM 363 >5AWM-A nrPDB Length = 394 Score = 256 bits (654), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 144/353 (40%), Positives = 210/353 (59%), Gaps = 27/353 (7%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F + ++Y + PIG GA GIVC+A ++ T ++VAIKK++ F N AKR RE KL++ Sbjct: 40 FTIHSRY-INLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK 98 Query: 116 HMDHENIVAIRDIIPPPLRN--AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQI 173 ++H+NI+ + + P RN F DVY+ ELMD +L Q+I+ + L + Y LYQ+ Sbjct: 99 LVNHKNIIGLLNAFTPQ-RNLEEFQDVYLVMELMDANLCQVIQMD--LDHDRMSYLLYQM 155 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 L G+K++HSA ++HRDLKPSN+++ A+C LKI DFGLAR + MT YVVTR+YRAPE Sbjct: 156 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPE 215 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 ++L YT +D+WSVGCI E++ LFPG DH+ Q ++E +GTPS ++ L Sbjct: 216 VILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 274 Query: 294 NAKRYIRQLPPYPRQSITDKFP-TVHPL------------AIDLIEKMLTFDPRRRITVL 340 + Y+ P Y S FP + P A +L+ KML DP +RI+V Sbjct: 275 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVD 334 Query: 341 DALAHPYLNSLHDISD----EPECTIPFNFDFENHALSEEQMKELIYREALAF 389 +AL H Y+N +D + PE P++ + + EQ KELIY E + + Sbjct: 335 EALKHEYINVWYDAEEVDAPAPE---PYDHSVDEREHTVEQWKELIYEEVMDY 384 >3OZ6-A nrPDB Length = 388 Score = 248 bits (632), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 145/364 (39%), Positives = 217/364 (59%), Gaps = 51/364 (14%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVA 124 + +GKGAYGIV +++ T E VA+KKI +AF N DA+RT REI +L + HENIV Sbjct: 14 VKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIVN 73 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + +++ + DVY+ ++ M+TDLH +IR+N L H QY +YQ+++ +KY+HS Sbjct: 74 LLNVLRA---DNDRDVYLVFDYMETDLHAVIRAN-ILEPVHKQYVVYQLIKVIKYLHSGG 129 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLAR-------VTS---------------ESDFMTE 222 +LHRD+KPSN+LLNA C +K+ DFGL+R VT+ + +T+ Sbjct: 130 LLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTD 189 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 YV TRWYRAPE+LL S+ YT ID+WS+GCI E++ KP+FPG ++QL ++ +I Sbjct: 190 YVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGVIDF 249 Query: 283 PSEEELEFLNE-NAKRYIRQLPPYP--RQS----ITDKFPTV----------HPLAIDLI 325 PS E++E + AK I L RQS I K+ + + A+DL+ Sbjct: 250 PSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALDLL 309 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC----TIPFNFDFENHALSEEQMKEL 381 +K+L F+P +RI+ DAL HP+++ H+ ++EP C TIP N +N S + + L Sbjct: 310 DKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPIN---DNVKHSIDDYRNL 366 Query: 382 IYRE 385 +Y E Sbjct: 367 VYSE 370 >3N9X-A nrPDB Length = 432 Score = 245 bits (626), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 140/377 (37%), Positives = 213/377 (56%), Gaps = 53/377 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G+YG V A + T ++VAIKK+ F++ ID KR LREI +L + + I+ + D+ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 I P F+++YI E+ D+DL ++ ++ L+EEH + LY +L G +IH + ++HR Sbjct: 94 IIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESGIIHR 153 Query: 189 DLKPSNLLLNANCDLKICDFGLAR-VTSESDF----------------------MTEYVV 225 DLKP+N LLN +C +K+CDFGLAR + SE D +T +VV Sbjct: 154 DLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVV 213 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM-----------DRKPLFPGRD------ 268 TRWYRAPEL+L +YT +ID+WS GCIF EL+ +R PLFPG Sbjct: 214 TRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLSP 273 Query: 269 -----HVH------QLRLLMELIGTPSEEELEFLNE-NAKRYIRQLPPYPRQSITDKFPT 316 VH QL ++ +IGTP+E++L+ +N+ +YI+ P ++ K+P+ Sbjct: 274 DRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYPS 333 Query: 317 VHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENH-ALSE 375 + I+L+E ML F+P +RIT+ AL HPYL + E T F++ LSE Sbjct: 334 ISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLENFSTKKIILPFDDWMVLSE 393 Query: 376 EQMKELIYREALAFNPE 392 Q++ + +E +F+PE Sbjct: 394 TQLRYIFLKEVQSFHPE 410 >3NIE-A nrPDB Length = 429 Score = 241 bits (614), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 141/384 (36%), Positives = 218/384 (56%), Gaps = 64/384 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G+YG V A + N++VAIKK+ F++ ID KR LREI +L + + I+ + D+ Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 I P F+++YI E+ D+DL ++ ++ L+E+H + LY +L G K+IH + ++HR Sbjct: 96 IIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGIIHR 155 Query: 189 DLKPSNLLLNANCDLKICDFGLAR-VTSESDF-------------------------MTE 222 DLKP+N LLN +C +KICDFGLAR + S+ D +T Sbjct: 156 DLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTS 215 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM-----------DRKPLFPGR---- 267 +VVTRWYRAPEL+L +YT +ID+WS GCIF EL+ +R PLFPG Sbjct: 216 HVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCFP 275 Query: 268 ---DH----VH------QLRLLMELIGTPSEEELEFLN-ENAKRYIRQLPPYPRQSITDK 313 DH VH QL ++ +IGTP EE+L+ + + +YI+ P ++ K Sbjct: 276 LSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPTRDGIDLSKK 335 Query: 314 FPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN-----SLHDISDEPECTIPFNFDF 368 + ++ IDL+E ML F+ ++RIT+ AL+HPYL +L + S E + +PF+ Sbjct: 336 YSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTE-KIILPFD--- 391 Query: 369 ENHALSEEQMKELIYREALAFNPE 392 + LSE Q++ + +E +F+ + Sbjct: 392 DWMVLSETQLRYIFLKEIQSFHAD 415 >3PG1-A nrPDB Length = 362 Score = 240 bits (613), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 136/334 (40%), Positives = 189/334 (56%), Gaps = 14/334 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI---------ANAFDNKIDAKRTLREIKLLRHMDH 119 I G+YG VC+ ++SE VAIK++ N + KR LREI+LL H H Sbjct: 30 ISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHH 88 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLK 178 NI+ +RDI A + +Y+ ELM TDL Q+I + +S +H QYF+Y IL GL Sbjct: 89 PNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHILLGLH 148 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 +H A V+HRDL P N+LL N D+ ICDF LAR + T YV RWYRAPEL++ Sbjct: 149 VLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPELVMQF 208 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS-EEELEFLNENAKR 297 +T +D+WS GC+ E+ +RK LF G +QL ++E++GTP E+ + F + +A+ Sbjct: 209 KGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARD 268 Query: 298 YIR-QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 Y+R L P ++ T PT P+A+DLI KML F+P+RRI+ AL HPY SL D D Sbjct: 269 YLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESLFDPLD 328 Query: 357 EPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 E + F F+ M ++ E FN Sbjct: 329 LTE-GLSERFHFDESVTDVYDMHKIFTAEVERFN 361 >2I6L-A nrPDB Length = 320 Score = 237 bits (605), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 135/323 (41%), Positives = 197/323 (60%), Gaps = 20/323 (6%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 NI G F++ ++Y + P+G G G+V SA++++ ++ VAIKKI + K LR Sbjct: 3 NIHG--FDLGSRYMD-LKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALR 57 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLR---------NAFNDVYIAYELMDTDLHQIIRSNQA 160 EIK++R +DH+NIV + +I+ P N VYI E M+TDL ++ Sbjct: 58 EIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPL 117 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA-NCDLKICDFGLARVT----S 215 L EEH + F+YQ+LRGLKYIHSANVLHRDLKP+NL +N + LKI DFGLAR+ S Sbjct: 118 L-EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYS 176 Query: 216 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 ++E +VT+WYR+P LLL+ ++YT AID+W+ GCIF E++ K LF G + Q++L Sbjct: 177 HKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQL 236 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 ++E I EE+ + L YIR P + +T P + A+D +E++LTF P Sbjct: 237 ILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMD 296 Query: 336 RITVLDALAHPYLNSLHDISDEP 358 R+T +AL+HPY++ DEP Sbjct: 297 RLTAEEALSHPYMSIYSFPMDEP 319 >4AU8-A nrPDB Length = 296 Score = 198 bits (504), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 113/290 (38%), Positives = 169/290 (58%), Gaps = 17/290 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G YG V A N ET+E VA+K++ D++ LREI LL+ + H+NIV + D+ Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 73 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVLH 187 + ++ + + +E D DL + S N L E + FL+Q+L+GL + HS NVLH Sbjct: 74 L-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RDLKP NLL+N N +LK+ DFGLAR + VVT WYR P++L + Y+ +ID Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 188 Query: 247 VWSVGCIFMELMDR-KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 +WS GCIF EL + +PLFPG D QL+ + L+GTP+EE+ + + + PY Sbjct: 189 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK-----LPDYKPY 243 Query: 306 P----RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 P S+ + P ++ DL++ +L +P +RI+ +AL HPY + Sbjct: 244 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 >3NIZ-A nrPDB Length = 311 Score = 197 bits (502), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 105/285 (36%), Positives = 165/285 (57%), Gaps = 8/285 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G YG+V A +S+ VA+K+I +++ +REI LL+ + H NIV++ D+ Sbjct: 29 VGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVSLIDV 87 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANVLH 187 I ++ + + +E M+ DL +++ N+ L + + +LYQ+LRG+ + H +LH Sbjct: 88 I-----HSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILH 142 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RDLKP NLL+N++ LK+ DFGLAR T VVT WYRAP++L+ S Y+ ++D Sbjct: 143 RDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYSTSVD 202 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 +WS+GCIF E++ KPLFPG QL + ++GTP+ E + E R + Sbjct: 203 IWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFE 262 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 ++ + P IDL+ ML FDP +RI+ DA+ HPY L Sbjct: 263 KKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL 307 >2BPM-A nrPDB Length = 309 Score = 195 bits (496), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 107/286 (37%), Positives = 160/286 (55%), Gaps = 9/286 (3%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G YG+V A N T E VA+KKI + + +REI LL+ ++H NIV + D+ Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 74 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANVL 186 I + N +Y+ +E + DL + + ++ + + +L+Q+L+GL + HS VL Sbjct: 75 I-----HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 129 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLKP NLL+N +K+ DFGLAR T VVT WYRAPE+LL Y+ A+ Sbjct: 130 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 189 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+GCIF E++ R+ LFPG + QL + +GTP E + + Y P + Sbjct: 190 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT-SMPDYKPSFPKW 248 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 RQ + P + L+ +ML +DP +RI+ ALAHP+ + Sbjct: 249 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 294 >5G6V-A nrPDB Length = 324 Score = 194 bits (493), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 115/315 (36%), Positives = 169/315 (53%), Gaps = 16/315 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G Y V + T+ VA+K+I + +RE+ LL+ + H NIV + DI Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCT-AIREVSLLKDLKHANIVTLHDI 68 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEH-CQYFLYQILRGLKYIHSANVLH 187 I + + + +E +D DL Q + + H + FL+Q+LRGL Y H VLH Sbjct: 69 I-----HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLH 123 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RDLKP NLL+N +LK+ DFGLAR S + VVT WYR P++LL S+DY+ ID Sbjct: 124 RDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQID 183 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 +W VGCIF E+ +PLFPG QL + ++GTP+EE + N + P Y Sbjct: 184 MWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR 243 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD-ISDEPECTIPFN 365 +++ P + DL+ K+L F+ R RI+ DA+ HP+ SL + I P+ T F Sbjct: 244 AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIF- 302 Query: 366 FDFENHALSEEQMKE 380 AL E Q+++ Sbjct: 303 ------ALKEIQLQK 311 >6GU6-A nrPDB Length = 302 Score = 193 bits (491), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 110/293 (37%), Positives = 163/293 (55%), Gaps = 16/293 (5%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG+G YG+V + T + VA+KKI + + +REI LL+ + H NIV++ Sbjct: 12 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 71 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQILRGLKYIHS 182 +D++ R +Y+ +E + DL + + S Q + + +LYQIL+G+ + HS Sbjct: 72 QDVLMQDSR-----LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 126 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRDLKP NLL++ +K+ DFGLAR T VVT WYR+PE+LL S+ Y Sbjct: 127 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 186 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE---ELEFLNENAKRY 298 + +D+WS+G IF EL +KPLF G + QL + +GTP+ E E+E L + Y Sbjct: 187 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD----Y 242 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 P + S+ + +DL+ KML +DP +RI+ AL HPY N L Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >4AGU-A nrPDB Length = 311 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 100/294 (34%), Positives = 166/294 (56%), Gaps = 8/294 (2%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG+G+YG+V N +T + VAIKK + D+ + K LREI++L+ + H N+V + Sbjct: 8 IGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 ++ R +++ +E D T LH++ R + + E + +Q L+ + + H N Sbjct: 68 LEVFRRKRR-----LHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHN 122 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 +HRD+KP N+L+ + +K+CDFG AR+ T SD+ + V TRWYR+PELL+ + Y Sbjct: 123 CIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGP 182 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +DVW++GC+F EL+ PL+PG+ V QL L+ + +G + + N ++P Sbjct: 183 PVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIP 242 Query: 304 -PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 P + + KFP + A+ L++ L DP R+T L HPY ++ +I D Sbjct: 243 DPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >1V0B-A nrPDB Length = 288 Score = 188 bits (478), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 113/291 (38%), Positives = 160/291 (54%), Gaps = 27/291 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G YG+V A N+ E+ A+KKI +++ T+REI +L+ + H NIV + D+ Sbjct: 10 IGEGTYGVVYKAQNN-YGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDV 68 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLH 187 I R + + +E +D DL +++ + L + FL Q+L G+ Y H VLH Sbjct: 69 IHTKKR-----LVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLH 123 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RDLKP NLL+N +LKI DFGLAR T VVT WYRAP++L+ S Y+ ID Sbjct: 124 RDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTID 183 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY--IRQLPP 304 +WSVGCIF E+++ PLFPG QL + ++GTP N+K + + +LP Sbjct: 184 IWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTP----------NSKNWPNVTELPK 233 Query: 305 Y-PRQSITDKFPTVHPL------AIDLIEKMLTFDPRRRITVLDALAHPYL 348 Y P ++ + P L IDL+ KML DP +RIT AL H Y Sbjct: 234 YDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >1G3N-A nrPDB Length = 326 Score = 185 bits (469), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 112/312 (35%), Positives = 171/312 (54%), Gaps = 26/312 (8%) Query: 66 IMPIGKGAYGIVCSAMN-SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD---HEN 121 + IG+GAYG V A + VA+K++ + T+RE+ +LRH++ H N Sbjct: 16 VAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEEHCQYFLYQILRGLKY 179 +V + D+ + + + +E +D DL + + E + ++Q+LRGL + Sbjct: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 +HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ S +T VVT WYRAPE+LL SS Sbjct: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS 195 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y +D+WSVGCIF E+ RKPLF G V QL ++++IG P EE+ + Sbjct: 196 -YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED----------WP 244 Query: 300 RQLPPYPRQSI-------TDKFPT-VHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 R + PRQ+ +KF T + L DL+ K LTF+P +RI+ AL+HPY L Sbjct: 245 RDV-ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 Query: 352 HDISDEPECTIP 363 + + +P Sbjct: 304 ERCKENLDSHLP 315 >5AIR-A nrPDB Length = 430 Score = 184 bits (467), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 102/293 (34%), Positives = 167/293 (56%), Gaps = 17/293 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G++G+V A ++ E VAIKK+ D + RE++++R +DH NIV +R Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCNIVRLRYF 125 Query: 129 IPPPLRNAFNDVYI--AYELMDTDLHQIIR----SNQALSEEHCQYFLYQILRGLKYIHS 182 ++VY+ + + ++++ R + Q L + + ++YQ+ R L YIHS Sbjct: 126 FYSSGEKK-DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 184 Query: 183 ANVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 + HRD+KP NLLL+ + LK+CDFG A+ + Y+ +R+YRAPEL+ ++DY Sbjct: 185 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY 244 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 T++IDVWS GC+ EL+ +P+FPG V QL +++++GTP+ E++ +N N + + Sbjct: 245 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF--K 302 Query: 302 LPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 P T F P P AI L ++L + P R+T L+A AH + + L D Sbjct: 303 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 >4NST-A nrPDB Length = 351 Score = 184 bits (467), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 166/301 (55%), Gaps = 28/301 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAIR 126 IG+G YG V A + +T E VA+KK+ DN+ + +REIK+LR + H ++V ++ Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVR--LDNEKEGFPITAIREIKILRQLIHRSVVNMK 78 Query: 127 DIIPPP-----LRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYI 180 +I+ + Y+ +E MD DL ++ S SE+H + F+ Q++ GL+Y Sbjct: 79 EIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYC 138 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARV--TSESDFMTEYVVTRWYRAPELLLNS 238 H N LHRD+K SN+LLN + +K+ DFGLAR+ + ES T V+T WYR PELLL Sbjct: 139 HKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGE 198 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE------ELEFLN 292 YT AIDVWS GCI EL +KP+F + QL L+ L G+P +L + N Sbjct: 199 ERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFN 258 Query: 293 --ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + K+Y R+ + ++F + A+DL++ MLT DP +R T L +L Sbjct: 259 TMKPKKQY--------RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 310 Query: 351 L 351 + Sbjct: 311 V 311 >1UA2-A nrPDB Length = 346 Score = 184 bits (466), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 112/301 (37%), Positives = 164/301 (54%), Gaps = 16/301 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRT-LREIKLLRHMDHENIVAI 125 +G+G + V A + TN+ VAIKKI + + K RT LREIKLL+ + H NI+ + Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 D +++ + ++ M+TDL II+ N L+ H + ++ L+GL+Y+H Sbjct: 78 LDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 +LHRDLKP+NLLL+ N LK+ DFGLA+ S + T VVTRWYRAPELL + Y Sbjct: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL-EFLNENAKRYIRQL 302 +D+W+VGCI EL+ R P PG + QL + E +GTP+EE+ + + + Sbjct: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTI 362 P P I F +DLI+ + F+P RIT AL Y ++ P C + Sbjct: 253 PGIPLHHI---FSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN--RPGPTPGCQL 307 Query: 363 P 363 P Sbjct: 308 P 308 >4BBM-A nrPDB Length = 331 Score = 183 bits (465), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/297 (34%), Positives = 165/297 (55%), Gaps = 9/297 (3%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+ KY+ + +G+G+YG+V N +T VAIKK + D+K+ K +REIKLL+ Sbjct: 21 FQSMEKYEN-LGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLK 79 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQIL 174 + HEN+V + ++ R Y+ +E +D T L + L + Q +L+QI+ Sbjct: 80 QLRHENLVNLLEVCKKKKR-----WYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII 134 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPE 233 G+ + HS N++HRD+KP N+L++ + +K+CDFG AR + + + + V TRWYRAPE Sbjct: 135 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 LL+ Y A+DVW++GC+ E+ +PLFPG + QL +M +G E N+ Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 254 Query: 294 NAKRYIRQLPPYP-RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 N +LP R+ + ++P + + IDL +K L DP +R + L H + Sbjct: 255 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >5EFQ-A nrPDB Length = 347 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 110/302 (36%), Positives = 163/302 (53%), Gaps = 28/302 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAIR 126 IG+G YG V A + +T E VA+KK+ DN+ + +REIK+LR + H++I+ ++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVR--LDNEKEGFPITAIREIKILRQLTHQSIINMK 76 Query: 127 DIIPPP-----LRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYI 180 +I+ + Y+ +E MD DL ++ S +E H + F+ Q++ GL Y Sbjct: 77 EIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYC 136 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELLLNS 238 H N LHRD+K SN+LLN +K+ DFGLAR+ S ES T V+T WYR PELLL Sbjct: 137 HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 196 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE------ELEFLN 292 YT AIDVWS GCI EL +KP+F + QL L+ + G+P +L + N Sbjct: 197 ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 256 Query: 293 --ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + K+Y R+ + ++F + A+DL + ML DP +R T AL +L Sbjct: 257 TMKPKKQY--------RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 308 Query: 351 LH 352 + Sbjct: 309 VE 310 >4KRC-A nrPDB Length = 317 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 106/298 (35%), Positives = 164/298 (55%), Gaps = 31/298 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-----TLREIKLLRHMDHENIV 123 +G G Y V +N T VA+K++ K+D++ +REI L++ + HENIV Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEV------KLDSEEGTPSTAIREISLMKELKHENIV 66 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN------QALSEEHCQYFLYQILRGL 177 + D+I + N + + +E MD DL + + S + L +YF +Q+L+GL Sbjct: 67 RLYDVI-----HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELL 235 + H +LHRDLKP NLL+N LK+ DFGLAR + F +E VVT WYRAP++L Sbjct: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDVL 180 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + S Y+ +ID+WS GCI E++ KPLFPG + QL+L+ +++GTP+E + + Sbjct: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Query: 296 KR--YIRQLPPYPRQSITDKFPTVHPL---AIDLIEKMLTFDPRRRITVLDALAHPYL 348 K I+Q PP + + T PL +D + +L +P R++ AL HP+ Sbjct: 241 KYNPNIQQRPPRDLRQVLQPH-TKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 >4BGQ-A nrPDB Length = 304 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 96/287 (33%), Positives = 167/287 (58%), Gaps = 11/287 (3%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+GAYG+V + ET+E VAIKK ++ +N+ + TLRE+K+LR + ENIV +++ Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLH 187 +Y+ +E ++ ++ +++ + E + ++YQ+++ + + H +++H Sbjct: 80 F-----RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVH 134 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMT--EYVVTRWYRAPELLLNSSDYTAAI 245 RD+KP NLL++ N LK+CDFG AR SE + E V TRWYR+PELLL + Y ++ Sbjct: 135 RDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP-YGKSV 193 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WSVGCI EL D +PLFPG + QL + +++G E+++ N + + + P Sbjct: 194 DMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAV 253 Query: 306 PR-QSITDKFPTV-HPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 QS+ ++ + + + +DL++ +L DP R L HP + Sbjct: 254 NHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 300 >3EB0-A nrPDB Length = 383 Score = 177 bits (450), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 105/337 (31%), Positives = 180/337 (53%), Gaps = 48/337 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD- 127 +G G++GIVC + E+ + A+KK+ D + RE+ +++ +DH NI+ + D Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVLQ------DPRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 128 ----------------------------------IIPPPLRNAFNDVYIAY--ELMDTDL 151 +I P +N + +V + Y + + L Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-LKICDFGL 210 IRS +++ ++YQ+ R + +IHS + HRD+KP NLL+N+ + LK+CDFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 211 ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHV 270 A+ S+ Y+ +R+YRAPEL+L +++YT +ID+WS+GC+F EL+ KPLF G + Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 271 HQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHP-LAIDLIEKML 329 QL +++++GTP++E++ +N + + P + P P LAIDL+E++L Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTEV--RFPTLKAKDWRKILPEGTPSLAIDLLEQIL 306 Query: 330 TFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNF 366 ++P RI +A+AHP+ + L + S E E NF Sbjct: 307 RYEPDLRINPYEAMAHPFFDHLRN-SYESEVKNNSNF 342 >2W96-B nrPDB Length = 306 Score = 177 bits (448), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 106/296 (35%), Positives = 159/296 (53%), Gaps = 10/296 (3%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 T++Y+P + IG GAYG V A + + VA+K + + T+RE+ LLR ++ Sbjct: 3 TSRYEP-VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLE 61 Query: 119 ---HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQI 173 H N+V + D+ + V + +E +D DL + L E + + Q Sbjct: 62 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ S + VVT WYRAPE Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPE 181 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +LL S+ Y +D+WSVGCIF E+ RKPLF G QL + +LIG P E++ Sbjct: 182 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + P P QS+ P + L+ +MLTF+P +RI+ AL H YL+ Sbjct: 241 LPRGAFPPRGPRPVQSVV---PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 293 >4E7W-A nrPDB Length = 394 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 100/291 (34%), Positives = 164/291 (56%), Gaps = 16/291 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G++G+V A E++E VAIKK+ D + RE++++R + H N+V ++ Sbjct: 48 IGNGSFGVVFQAKLVESDE-VAIKKVLQ------DKRFKNRELQIMRIVKHPNVVDLKAF 100 Query: 129 I---PPPLRNAFNDVYIAY--ELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 F ++ + Y E + + Q + + ++YQ+LR L YIHS Sbjct: 101 FYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSI 160 Query: 184 NVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 + HRD+KP NLLL+ LK+ DFG A++ + Y+ +R+YRAPEL+ +++YT Sbjct: 161 GICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYT 220 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY-IRQ 301 ID+WS GC+ ELM +PLFPG + QL +++++GTPS E+++ +N N + Q Sbjct: 221 TNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQ 280 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 + P+P + P P AIDLI ++L + P R+T ++AL HP+ + L Sbjct: 281 IRPHPFSKVFR--PRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELR 329 >3GC0-A nrPDB Length = 329 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 97/291 (33%), Positives = 160/291 (54%), Gaps = 13/291 (4%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I +G+G YG V A+++ TNE+VAIK+I + + +RE+ LL+ + H NI+ + Sbjct: 39 ITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIEL 98 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + +I R +++ +E + DL + + N +S + FLYQ++ G+ + HS Sbjct: 99 KSVIHHNHR-----LHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRC 153 Query: 186 LHRDLKPSNLLLNANCD-----LKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSS 239 LHRDLKP NLLL+ + LKI DFGLAR T ++T WYR PE+LL S Sbjct: 154 LHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSR 213 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y+ ++D+WS+ CI+ E++ + PLFPG + QL + E++G P + + + Sbjct: 214 HYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA-LPDWK 272 Query: 300 RQLPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + P + +++ + +DL+ ML DP +RI+ +AL HPY + Sbjct: 273 QSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >3MIA-A nrPDB Length = 351 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 107/315 (33%), Positives = 160/315 (50%), Gaps = 36/315 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 +KY+ + IG+G +G V A + +T + VA+KK+ + + LREIK+L+ + Sbjct: 16 VSKYEK-LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 Query: 119 HENIVAIRDII---PPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQ 172 HEN+V + +I P +Y+ ++ + DL ++ + LSE + + Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQM 132 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-----TSESDFMTEYVVTR 227 +L GL YIH +LHRD+K +N+L+ + LK+ DFGLAR S+ + T VVT Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG--TPS- 284 WYR PELLL DY ID+W GCI E+ R P+ G HQL L+ +L G TP Sbjct: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Query: 285 ---------EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 E+LE + ++ +L Y R P A+DLI+K+L DP + Sbjct: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD----------PYALDLIDKLLVLDPAQ 302 Query: 336 RITVLDALAHPYLNS 350 RI DAL H + S Sbjct: 303 RIDSDDALNHDFFWS 317 >3E3P-A nrPDB Length = 360 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 112/339 (33%), Positives = 169/339 (49%), Gaps = 34/339 (10%) Query: 70 GKGAYGIVCSAMNSETNESVAIKKIAN--AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 G+G +G V T SVAIKK+ F N R L+ ++ L + H NIV ++ Sbjct: 32 GQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN-----RELQIMQDLAVLHHPNIVQLQS 86 Query: 128 IIPPPLRNAFNDVY--IAYELMDTDLHQIIRS----NQALSEEHCQYFLYQILRGLKYIH 181 D+Y + E + LH+ R+ A + FL+Q++R + +H Sbjct: 87 YFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLH 146 Query: 182 --SANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 S NV HRD+KP N+L+N A+ LK+CDFG A+ S S+ Y+ +R+YRAPEL+ + Sbjct: 147 LPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGN 206 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN---ENA 295 YT A+D+WSVGCIF E+M +P+F G + QL ++ ++G PS E L LN + Sbjct: 207 QHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDV 266 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 Y + P+ +D A DL+ +L + P R+ +AL HPY + LHD Sbjct: 267 DLYNSKGIPW-SNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFDELHD-- 323 Query: 356 DEPECTIPFNFDF----------ENHALSEEQMKELIYR 384 P +P N D E +SE Q +L+ + Sbjct: 324 --PATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKLVRK 360 >3ZDU-A nrPDB Length = 325 Score = 154 bits (389), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 87/285 (30%), Positives = 151/285 (52%), Gaps = 11/285 (3%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G+YG V + T + VAIK + ++ K +REIK L+ HEN+V + ++ Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN-KIAMREIKFLKQFHHENLVNLIEV 69 Query: 129 IPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 + +++ +E +D T L ++ L + + +L+QILR + Y+HS N++H Sbjct: 70 FRQKKK-----IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIH 124 Query: 188 RDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RD+KP N+L++ + K+CDFG AR + + D + V TRWYRAPEL+L + Y +D Sbjct: 125 RDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPVD 184 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP--P 304 +W++GC+ +E+ P P + L ++ +G S +++ LP Sbjct: 185 IWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQ 244 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 +P+ + K+P ++ L D++ L DP RI+ D L H Y Sbjct: 245 HPKNA-RKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >5Y86-A nrPDB Length = 588 Score = 144 bits (363), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 97/315 (30%), Positives = 158/315 (50%), Gaps = 40/315 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V + + + VA+K + N K ++ EI++L H+ ++ ++ Sbjct: 215 IGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQDKTGSMNV 271 Query: 129 IPPPLRNAF-NDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANV 185 I F N V +A+EL+ DL+++I+ N Q S + + F IL+ L +H + Sbjct: 272 IHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 Query: 186 LHRDLKPSNLLL--NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 +H DLKP N+LL + K+ DFG + E + Y+ +R+YRAPE++L S Y+ Sbjct: 332 IHCDLKPENILLKHHGRSSTKVIDFGSS--CFEYQKLYTYIQSRFYRAPEIILGSR-YST 388 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE-------FLNEN-- 294 ID+WS GCI EL+ +PLFPG D QL +MEL+G P + LE F+N Sbjct: 389 PIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGI 448 Query: 295 --------------------AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 ++R ++ PP + T L I+ +++ L +DP Sbjct: 449 PRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPS 508 Query: 335 RRITVLDALAHPYLN 349 R+T AL HP+++ Sbjct: 509 ARLTPAQALRHPWIS 523 >4CRL-A nrPDB Length = 406 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 100/318 (31%), Positives = 167/318 (52%), Gaps = 47/318 (14%) Query: 69 IGKGAYGIV--CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G+G YG V + + ++ A+K+I + + REI LLR + H N+++++ Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQ 85 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA---------LSEEHCQYFLYQILRGL 177 + L +A V++ ++ + DL II+ ++A L + LYQIL G+ Sbjct: 86 KVF---LSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGI 142 Query: 178 KYIHSANVLHRDLKPSNLLLNA----NCDLKICDFGLARVTSE-----SDFMTEYVVTRW 228 Y+H+ VLHRDLKP+N+L+ +KI D G AR+ + +D + VVT W Sbjct: 143 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLAD-LDPVVVTFW 201 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD---------HVHQLRLLMEL 279 YRAPELLL + YT AID+W++GCIF EL+ +P+F R H QL + + Sbjct: 202 YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNV 261 Query: 280 IGTPSEEELEFLNENAKRYIRQLPPYPRQSITD----KFPTVHPL-----AIDLIEKMLT 330 +G P++++ E + + + + + + R + T+ K+ H + A L++K+LT Sbjct: 262 MGFPADKDWEDIKKMPE-HSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLT 320 Query: 331 FDPRRRITVLDALAHPYL 348 DP +RIT A+ PY Sbjct: 321 MDPIKRITSEQAMQDPYF 338 >3NCG-A nrPDB Length = 486 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 95/300 (31%), Positives = 144/300 (48%), Gaps = 45/300 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG++G V + T + A+K I A D LRE++LL+ +DH NI+ + +I Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 129 IPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + ++F ++Y EL D +II+ + SE + Q+ G+ Y+H N+ Sbjct: 90 LEDS--SSFYIVGELYTGGELFD----EIIKRKR-FSEHDAARIIKQVFSGITYMHKHNI 142 Query: 186 LHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 +HRDLKP N+LL + +CD+KI DFGL+ ++ M + + T +Y APE+L + Y Sbjct: 143 VHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT--YD 200 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 DVWS G I L+ P F G++ L+ + +Y L Sbjct: 201 EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ETGKYAFDL 243 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD----ISDEP 358 P + T+ A DLI KMLTF P RIT L HP++ ISD P Sbjct: 244 PQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLP 294 >3DFA-A nrPDB Length = 286 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 92/290 (31%), Positives = 144/290 (49%), Gaps = 41/290 (14%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +GKG++G V + T + A+K I A D LRE++LL+ +DH NI+ + Sbjct: 27 VCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKL 86 Query: 126 RDIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 +I+ ++F ++Y EL D +II+ + SE + Q+ G+ Y+H Sbjct: 87 FEILEDS--SSFYIVGELYTGGELFD----EIIKRKR-FSEHDAARIIKQVFSGITYMHK 139 Query: 183 ANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 N++HRDLKP N+LL + +CD+KI DFGL+ ++ M + + T +Y APE+L + Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT- 198 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y DVWS G I L+ P F G++ L+ + +Y Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ETGKYA 240 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 LP + ++I+D A DLI KMLTF P RIT L HP++ Sbjct: 241 FDLPQW--RTISDD-------AKDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >5ZTN-A nrPDB Length = 429 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 93/315 (29%), Positives = 160/315 (50%), Gaps = 42/315 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V A + + ++ VA+K + N A +R ++ LR D +N + + + Sbjct: 105 IGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHM 164 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANVL 186 + N + + +EL+ +L+++I+ N Q S + F + IL+ L +H ++ Sbjct: 165 LEN--FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRII 222 Query: 187 HRDLKPSNLLLN--ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H DLKP N+LL +K+ DFG + E + Y+ +R+YRAPE++L + Y Sbjct: 223 HCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYTYIQSRFYRAPEVILGAR-YGMP 279 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 ID+WS+GCI EL+ PL PG D QL ++EL+G PS++ L+ ++ AK ++ Sbjct: 280 IDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLD-ASKRAKNFVSS-KG 337 Query: 305 YPR----QSITDKFPTVH---------------------------PLAIDLIEKMLTFDP 333 YPR +++D ++ PL +D +++ L +DP Sbjct: 338 YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP 397 Query: 334 RRRITVLDALAHPYL 348 R+T AL HP+L Sbjct: 398 AVRMTPGQALRHPWL 412 >5JN2-A nrPDB Length = 525 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 107/358 (29%), Positives = 168/358 (46%), Gaps = 63/358 (17%) Query: 1 MDGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTA 60 + G +G+P + GG PG +++ AT G F+Q++ IF + Sbjct: 26 LGGAAGEPRSRGHAAGTSGG----------PG-DHLHAT---PGMFVQHST--AIF--SD 67 Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDH 119 +YK + +GKG++G V + T + A+K I+ K D + LRE++LL+ +DH Sbjct: 68 RYKGQRV-LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 120 ENIVAIRDIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 NI+ + + + F +VY EL D I S + SE + Q+L G Sbjct: 127 PNIMKLYEFFED--KGYFYLVGEVYTGGELFDE-----IISRKRFSEVDAARIIRQVLSG 179 Query: 177 LKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 + Y+H ++HRDLKP NLLL + + +++I DFGL+ S M + + T +Y APE Sbjct: 180 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE 239 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L + Y DVWS G I L+ P F G + E + L + Sbjct: 240 VLHGT--YDEKCDVWSTGVILYILLSGCPPFNGAN------------------EYDILKK 279 Query: 294 NAK-RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 K +Y +LP + + V A DLI KMLT+ P RI+ DAL H ++ + Sbjct: 280 VEKGKYTFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQT 328 >2YCR-A nrPDB Length = 323 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 89/293 (30%), Positives = 144/293 (49%), Gaps = 43/293 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN---AFDNKIDAKRTLR---EIKLLRHMDHENI 122 +G GA G V A +T + VAIK I+ A + +A L EI++L+ ++H I Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 + I++ D YI ELM+ +L + N+ L E C+ + YQ+L ++Y+H Sbjct: 78 IKIKNFFDA------EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH 131 Query: 182 SANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN- 237 ++HRDLKP N+LL++ +C +KI DFG +++ E+ M T Y APE+L++ Sbjct: 132 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSV 191 Query: 238 -SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 ++ Y A+D WS+G I + P P +H Q+ L Sbjct: 192 GTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLK-------------------- 229 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 Q+ I + + V A+DL++K+L DP+ R T +AL HP+L Sbjct: 230 ---DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQ 279 >3I6U-A nrPDB Length = 419 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 144/293 (49%), Gaps = 43/293 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN---AFDNKIDAKRTLR---EIKLLRHMDHENI 122 +G GA G V A +T + VAI+ I+ A + +A L EI++L+ ++H I Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 + I++ D YI ELM+ +L + N+ L E C+ + YQ+L ++Y+H Sbjct: 203 IKIKNFFDA------EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH 256 Query: 182 SANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN- 237 ++HRDLKP N+LL++ +C +KI DFG +++ E+ M T Y APE+L++ Sbjct: 257 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSV 316 Query: 238 -SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 ++ Y A+D WS+G I + P P +H Q+ L Sbjct: 317 GTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLK-------------------- 354 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 Q+ I + + V A+DL++K+L DP+ R T +AL HP+L Sbjct: 355 ---DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQ 404 >3MA6-A nrPDB Length = 298 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 98/315 (31%), Positives = 152/315 (48%), Gaps = 49/315 (15%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKI 102 G F+Q++ IF + +YK + +GKG++G V + T + A+K I+ K Sbjct: 20 GMFVQHST--AIF--SDRYKGQRV-LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKT 74 Query: 103 DAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQ 159 D + LRE++LL+ +DH NI+ + + + F +VY EL D I S + Sbjct: 75 DKESLLREVQLLKQLDHPNIMKLYEFFED--KGYFYLVGEVYTGGELFDE-----IISRK 127 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSE 216 SE + Q+L G+ Y+H ++HRDLKP NLLL + + +++I DFGL+ Sbjct: 128 RFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA 187 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 S M + + T +Y APE+L + Y DVWS G I L+ P F G + Sbjct: 188 SKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGAN-------- 237 Query: 277 MELIGTPSEEELEFLNENAK-RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 E + L + K +Y +LP + + V A DLI KMLT+ P Sbjct: 238 ----------EYDILKKVEKGKYTFELPQWKK---------VSESAKDLIRKMLTYVPSM 278 Query: 336 RITVLDALAHPYLNS 350 RI+ DAL H ++ + Sbjct: 279 RISARDALDHEWIQT 293 >3LIJ-A nrPDB Length = 494 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 136/291 (46%), Gaps = 39/291 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G GAYG V + T+ AIK I + + L E+ +L+ +DH NI+ + Sbjct: 42 VKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKL 101 Query: 126 RDIIPPPLRNAF--NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 D RN + + Y EL D +H++ +E + Q+L G+ Y+H Sbjct: 102 YDFFEDK-RNYYLVMECYKGGELFDEIIHRM-----KFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 184 NVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 N++HRDLKP NLLL + + +KI DFGL+ V M E + T +Y APE+L Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RKK 213 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 Y DVWS+G I L+ P F G+ LR + + T E + ++E AK Sbjct: 214 YDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAK---- 269 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 DLI++ML FD +RRI+ AL HP++ + Sbjct: 270 ----------------------DLIKQMLQFDSQRRISAQQALEHPWIKEM 298 >4IAN-A nrPDB Length = 358 Score = 120 bits (302), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 103/346 (29%), Positives = 163/346 (47%), Gaps = 71/346 (20%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAM-NSETNESVAIKKIANAFDNKIDAKRTLREI- 111 NI EV K G+G + V A N+ N+ VA+K I N N++ K L+E+ Sbjct: 23 NIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN---NELMQKTGLKELE 79 Query: 112 -----------------KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQI 154 +L RH H+ + + + PL +V Y D LH Sbjct: 80 FLKKLNDADPDDKFHCLRLFRHFYHKQHLCL---VFEPLSMNLREVLKKYG-KDVGLH-- 133 Query: 155 IRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARV 213 I++ ++ S+ Q+ LK + N+LH D+KP N+L+N + LK+CDFG A Sbjct: 134 IKAVRSYSQ--------QLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASH 185 Query: 214 TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 +++D +T Y+V+R+YRAPE+++ S Y ID+WSVGC EL K LFPG+ + H L Sbjct: 186 VADND-ITPYLVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 243 Query: 274 RLLMELIGTPSEEEL-------EFLNENAK-RYIRQLPPYPRQSIT-------------- 311 +L M+L G + + + ++N YI R+ +T Sbjct: 244 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLAD 303 Query: 312 ---------DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 D+ VH L DL++++L DP +RI++ AL H ++ Sbjct: 304 LIGCQRLPEDQRKKVHQLK-DLLDQILMLDPAKRISINQALQHAFI 348 >4RGJ-A nrPDB Length = 520 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 101/314 (32%), Positives = 147/314 (46%), Gaps = 50/314 (15%) Query: 44 GRFIQ-YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA-FDNK 101 G FIQ N+ N +YK I +GKG++G V + + T AIK I+ K Sbjct: 48 GMFIQNSNVVFN-----EQYKG-IKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRK 101 Query: 102 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSN 158 D + LRE++LL+ +DH NI+ + + N + +DVY EL D I S Sbjct: 102 TDKESLLREVELLKMLDHINIMKLYEFFED--NNYYYLVSDVYTGGELFDE-----IISR 154 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD----LKICDFGLARVT 214 + E + QIL G+ Y+H NV+HRDLKP N+LL +KI DFGL+ Sbjct: 155 KRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF 214 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 S M + + T +Y AP++L + Y D+WS G I L+ P F G + L+ Sbjct: 215 EYSKKMKDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILK 272 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 + A +Y LP + + I+DK A DLI+KML + Sbjct: 273 KV-----------------EAGKYTFDLPQFKK--ISDK-------AKDLIKKMLMYTSA 306 Query: 335 RRITVLDALAHPYL 348 RI+ DAL H ++ Sbjct: 307 VRISARDALEHEWI 320 >2PVN-A nrPDB Length = 352 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 65/206 (31%), Positives = 116/206 (56%), Gaps = 19/206 (9%) Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC-DLKICDFGLARVTSESD 218 L++ +Y++Y++L+ L Y HS ++HRD+KP N++++ L++ D+GLA Sbjct: 142 TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGK 201 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLM 277 V +R+++ PELL++ DY ++D+WS+GC+F ++ RK P F G D+ QL + Sbjct: 202 EYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIA 261 Query: 278 ELIGTPS------------EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 +++GT + +LE L R+ R+ P+ + D V P AID + Sbjct: 262 KVLGTDGLNAYLNKYRIELDPQLEAL---VGRHSRK--PWLKFMNADNQHLVSPEAIDFL 316 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSL 351 +K+L +D + R+T L+A+ HPY + Sbjct: 317 DKLLRYDHQERLTALEAMTHPYFQQV 342 >4MD7-E nrPDB Length = 391 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 156/301 (51%), Gaps = 30/301 (9%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G+G Y V A+N NE V +K + K KR ++ ++ LR NI+ + Sbjct: 42 VRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLR--GGPNIITL 97 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 DI+ P+ + + +TD Q+ Q L++ ++++Y+IL+ L Y HS + Sbjct: 98 ADIVKDPVSRT--PALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI 152 Query: 186 LHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 +HRD+KP N++++ + L++ D+GLA V +R+++ PELL++ Y + Sbjct: 153 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 212 Query: 245 IDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+WS+GC+ ++ RK P F G D+ QL + +++GT E L + +Y +L Sbjct: 213 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNIELD 266 Query: 304 P-------------YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 P + R ++ V P A+D ++K+L +D + R+T +A+ HPY + Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 Query: 351 L 351 + Sbjct: 327 V 327 >5IG1-A nrPDB Length = 344 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 145/304 (47%), Gaps = 44/304 (14%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 F ++++V K K + IGKGA+ V +N T E A+K IA + + REI Sbjct: 10 FFDLYDVDLKDKRSV--IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREI 67 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFND---VYIAYELMDT-DLHQIIRSNQALSEEHCQ 167 + + HE+IV+ +R AF D Y+ +E + +L I + + +E+ Sbjct: 68 GICSSLQHEHIVS--------MRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDAS 119 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYV 224 ++QIL L++ HS N++HRDLKP NLLL + N +KI DFGLA + + + Sbjct: 120 ACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFA 179 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 T Y +PE++ Y A+DVW+ G I L+ P F DH +L Sbjct: 180 GTPGYLSPEVI-RRVPYDTAVDVWACGVILYILLVGYPPFWEEDH-------QKLYAQIK 231 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 + +F P P ++ +V A +LI+ ML +P+RR TV + L Sbjct: 232 NCQYDF-------------PSP------EWDSVTTAAKELIKAMLEPNPKRRPTVQELLQ 272 Query: 345 HPYL 348 HP++ Sbjct: 273 HPWI 276 >6EII-A nrPDB Length = 352 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 156/301 (51%), Gaps = 30/301 (9%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G+G Y V A+N NE V +K + K KR ++ ++ LR NI+ + Sbjct: 65 VRKLGRGKYSEVFEAINITNNEKVVVKILKPV--KKKKIKREIKILENLR--GGPNIITL 120 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 DI+ P+ + + +TD Q+ Q L++ ++++Y+IL+ L Y HS + Sbjct: 121 ADIVKDPVSRT--PALVFEHVNNTDFKQLY---QTLTDYDIRFYMYEILKALDYCHSMGI 175 Query: 186 LHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 +HRD+KP N++++ + L++ D+GLA V +R+++ PELL++ Y + Sbjct: 176 MHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYS 235 Query: 245 IDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+WS+GC+ ++ RK P F G D+ QL + +++GT E L + +Y +L Sbjct: 236 LDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNIELD 289 Query: 304 P-------------YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 P + R ++ V P A+D ++K+L +D + R+T +A+ HPY + Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 349 Query: 351 L 351 + Sbjct: 350 V 350 >4MVF-A nrPDB Length = 506 Score = 114 bits (284), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 82/288 (28%), Positives = 134/288 (46%), Gaps = 39/288 (13%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+G YG V ++ TN+ AIK+ D + R +EI++++ +DH NIV + + Sbjct: 64 KLGQGTYGCVYKGIDKVTNQLYAIKE--EKKDRLKNINRFFQEIEIMKKLDHPNIVKLYE 121 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 N +Y+ EL +L I N + +E++ + QI + Y+HS N++ Sbjct: 122 TYEND-----NYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIV 176 Query: 187 HRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 HRDLKP N L N + LKI DFGL++ +F T T +Y AP++L Y Sbjct: 177 HRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL--DGKYDK 234 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 D+WS G I L+ P F G E++ + E F + Sbjct: 235 KCDIWSSGVIMYTLLCGYPPFYGDTD-------NEVLKKVKKGEFCFYEND--------- 278 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + ++ A +LI K+LT++P R T+ +AL HP++ + Sbjct: 279 ----------WGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 >6HMD-A nrPDB Length = 365 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 158/298 (53%), Gaps = 30/298 (10%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G+G Y V A+N NE V +K + K KR ++ ++ LR NI+ + Sbjct: 58 VRKLGRGKYSEVFEAINITNNERVVVKILKPV--KKKKIKREVKILENLR--GGTNIIKL 113 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 D + P+ V+ + +TD Q+ Q L++ ++++Y++L+ L Y HS + Sbjct: 114 IDTVKDPVSKTPALVFEY--INNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGI 168 Query: 186 LHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 +HRD+KP N++++ L++ D+GLA + V +R+++ PELL++ Y + Sbjct: 169 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYS 228 Query: 245 IDVWSVGCIFMELM-DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+WS+GC+ ++ R+P F G+D+ QL + +++GT EE +L K+Y L Sbjct: 229 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYL----KKYHIDLD 282 Query: 304 PYPRQSI-------------TDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P+ + ++ V P A+DL++K+L +D ++R+T +A+ HPY Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >3H4J-B nrPDB Length = 336 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 137/284 (48%), Gaps = 40/284 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMDHENIVAIRD 127 +G+G++G V A + +T + VA+K I+ K D R REI L+ + H +I+ + D Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 +I P D+ + E +L I + ++E+ + F QI+ ++Y H ++H Sbjct: 77 VITTP-----TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVH 131 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA-AID 246 RDLKP NLLL+ N ++KI DFGL+ + ++ +F+ + Y APE ++N Y +D Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPE-VINGKLYAGPEVD 190 Query: 247 VWSVGCI-FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 VWS G + ++ L+ R P +E + L + + +P + Sbjct: 191 VWSCGIVLYVMLVGRLPF--------------------DDEFIPNLFKKVNSCVYVMPDF 230 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + P A LI +M+ DP +RIT+ + P+ N Sbjct: 231 -----------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 >2F57-A nrPDB Length = 317 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 86/317 (27%), Positives = 150/317 (47%), Gaps = 50/317 (15%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMD 118 +Y + IG+G+ GIVC A T + VA+KK+ D + +R L E+ ++R Sbjct: 45 EYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM----DLRKQQRRELLFNEVVIMRDYH 100 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 H+N+V D+ L +++++ E ++ I ++ ++EE +LR L Sbjct: 101 HDNVV---DMYSSYLVG--DELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALS 155 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLN 237 Y+H+ V+HRD+K ++LL ++ +K+ DFG A+V+ E V T ++ APE +++ Sbjct: 156 YLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE-VIS 214 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE---N 294 Y +D+WS+G + +E++D +P + NE Sbjct: 215 RLPYGTEVDIWSLGIMVIEMIDGEP--------------------------PYFNEPPLQ 248 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 A R IR P PR K +V +DL ML +P +R T + L HP+L + Sbjct: 249 AMRRIRDSLP-PRVKDLHKVSSVLRGFLDL---MLVREPSQRATAQELLGHPFLK----L 300 Query: 355 SDEPECTIPFNFDFENH 371 + P C +P + +H Sbjct: 301 AGPPSCIVPLMRQYRHH 317 >3MN3-A nrPDB Length = 271 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 140/299 (46%), Gaps = 41/299 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMDHENIVA 124 + +G+G++G V A ++ T + VA+K I K D + R REI LR + H +I+ Sbjct: 9 VKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIK 68 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + D+I + +++ + E +L I +SE+ + F QI+ ++Y H Sbjct: 69 LYDVI-----KSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHK 123 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 ++HRDLKP NLLL+ + ++KI DFGL+ + ++ +F+ + Y APE++ Sbjct: 124 IVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPE 183 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +DVWS G I ++ R+ F +E + L +N + LP Sbjct: 184 VDVWSCGVILYVMLCRRLPF-------------------DDESIPVLFKNISNGVYTLPK 224 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIP 363 + + P A LI++ML +P RI++ + + + D PE +P Sbjct: 225 F-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK-----VDLPEYLLP 267 >2V7O-A nrPDB Length = 336 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 88/308 (28%), Positives = 144/308 (46%), Gaps = 43/308 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V + + A K I + D ++ RE ++ R + H NIV + D Sbjct: 39 LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 98 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I F+ Y+ ++L+ +L + I + + SE + ++QIL + +IH +++H Sbjct: 99 IS---EEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVH 153 Query: 188 RDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + C +K+ DFGLA V E + T Y +PE+L Y Sbjct: 154 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL-RKDPYGK 212 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ + +Q+ Sbjct: 213 PVDIWACGVI---------------------LYILLVGYPP-----FWDEDQHKLYQQIK 246 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY------LNSLHDISDE 357 + ++ TV P A +LI +MLT +P +RIT AL HP+ + S+ + Sbjct: 247 AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQET 306 Query: 358 PECTIPFN 365 EC FN Sbjct: 307 VECLRKFN 314 >6O6Q-A nrPDB Length = 335 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 73/297 (24%), Positives = 152/297 (51%), Gaps = 33/297 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRD 127 +G+G Y V ++ E E V IK + + K+ REI +L+++ D NI+A+ D Sbjct: 49 LGRGKYSEVFLGIDLEKREKVVIKVLK-----PVKRKKIKREISILKNLVDGPNIIAMLD 103 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++ P + I + + D + ++ ++++Y++L+ L Y HS ++H Sbjct: 104 VVREP--QSKTPGLIFEHINNIDFRSLY---PTFTDYDIRFYMYELLKALDYSHSMGIMH 158 Query: 188 RDLKPSNLLLNANCDL-KICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RD+KP N++++ + L ++ D+GLA V +R+++ PELL++ Y ++D Sbjct: 159 RDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLD 218 Query: 247 VWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPS-------------EEELEFLN 292 +WS GC+ ++ K P F G+ + QL ++ ++G+ + EE + Sbjct: 219 MWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGY 278 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 N ++++R + + ++ +F +DLI+++L +D + R+T +A+ H Y + Sbjct: 279 YNKRQWVRFMNENNKDLVSQEF-------LDLIDRLLRYDHQERLTAKEAMKHAYFD 328 >3VN9-A nrPDB Length = 340 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 137/269 (50%), Gaps = 26/269 (9%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-L 114 FEV A PIM +G+GAYG+V + + + +A+K+I A N + KR L ++ + + Sbjct: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 104 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL----HQIIRSNQALSEEHCQYFL 170 R +D V + R DV+I ELMDT L Q+I Q + E+ Sbjct: 105 RTVDCPFTVTFYGAL---FREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 Query: 171 YQILRGLKYIHSA-NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 I++ L+++HS +V+HRD+KPSN+L+NA +K+CDFG++ +S T + Y Sbjct: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 Query: 230 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--- 283 APE + LN Y+ D+WS+G +EL + FP + L +++ P Sbjct: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ 277 Query: 284 ------SEEELEFLNENAKRYIRQLPPYP 306 S E ++F ++ K+ ++ P YP Sbjct: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYP 306 >3BHH-A nrPDB Length = 295 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 89/308 (28%), Positives = 143/308 (46%), Gaps = 43/308 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKGA+ +V + T A K I + D ++ RE ++ R + H NIV + D Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDS 71 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I F+ Y+ ++L+ +L + I + + SE + + QIL + + H V+H Sbjct: 72 IS---EEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVH 126 Query: 188 RDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + C +K+ DFGLA V + + T Y +PE+L + Y Sbjct: 127 RDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA-YGK 185 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ + +Q+ Sbjct: 186 PVDIWACGVI---------------------LYILLVGYPP-----FWDEDQHKLYQQIK 219 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY------LNSLHDISDE 357 + ++ TV P A +LI +MLT +P +RIT +AL HP+ + S+ + Sbjct: 220 AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQET 279 Query: 358 PECTIPFN 365 EC FN Sbjct: 280 VECLKKFN 287 >5XVU-A nrPDB Length = 332 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 115/210 (54%), Gaps = 21/210 (10%) Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDF 219 +++ +Y++YQIL+ L Y HS ++HRD+KP N++++ N +++ +GLA Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQE 181 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLME 278 V +R+Y+ PELL++ Y ++D+WS+GC+ ++ +K P F G D+ QL + + Sbjct: 182 YNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAK 241 Query: 279 LIGTPSEEELEFLNENAKRYIRQLPPYPRQSIT--DKFPTVHPL-----------AIDLI 325 ++GT E L+ K+Y +L P+ + ++ P H L IDLI Sbjct: 242 VLGT------EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLI 295 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 +KML +D +RI +A+ HPY + + S Sbjct: 296 DKMLIYDHAKRIAPKEAMEHPYFREVREES 325 >2BDW-A nrPDB Length = 362 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 145/307 (47%), Gaps = 42/307 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V ++ T A K I + D ++ RE ++ R + H NIV + D Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 96 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +F+ Y+ ++L+ +L + I + + SE + + QIL + Y HS ++H Sbjct: 97 IQ---EESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVH 151 Query: 188 RDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 R+LKP NLLL + +K+ DFGLA ++S+ + T Y +PE +L Y+ Sbjct: 152 RNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE-VLKKDPYSKP 210 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+W+ G I L + L+G P F +E+ R Q+ Sbjct: 211 VDIWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYAQIKA 244 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS------DEP 358 + ++ TV P A LI+ MLT +P++RIT AL P++ + ++ D Sbjct: 245 GAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTV 304 Query: 359 ECTIPFN 365 +C FN Sbjct: 305 DCLKKFN 311 >2VN9-A nrPDB Length = 301 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 85/285 (29%), Positives = 135/285 (47%), Gaps = 37/285 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V M T + A K I + D ++ RE ++ R + H NIV + D Sbjct: 12 LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 71 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I F+ Y+ ++L+ +L + I + + SE + + QIL + + H ++H Sbjct: 72 IS---EEGFH--YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVH 126 Query: 188 RDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + +K+ DFGLA V + + T Y +PE+L Y Sbjct: 127 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL-RKDPYGK 185 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ R +Q+ Sbjct: 186 PVDMWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYQQIK 219 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + ++ TV P A DLI KMLT +P +RIT +AL HP++ Sbjct: 220 AGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >5FG8-A nrPDB Length = 285 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 132/285 (46%), Gaps = 37/285 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ IV + T A K I D ++ RE ++ R + H NIV + D Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHDS 81 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I N Y+ ++L+ +L + I + + SE + + QIL + + H V+H Sbjct: 82 IQEE-----NYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVH 136 Query: 188 RDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + +K+ DFGLA V + + T Y +PE +L Y Sbjct: 137 RDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPE-VLKKEPYGK 195 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 ++D+W+ G I L + L+G P F +E+ R Q+ Sbjct: 196 SVDIWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYSQIK 229 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + ++ TV P A +LI +MLT +P +RIT +AL HP++ Sbjct: 230 AGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >5X8I-B nrPDB Length = 346 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 88/332 (26%), Positives = 152/332 (45%), Gaps = 46/332 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 ++A+Y+ + +G+GA+G V ++ + KI D +A R+ EI++L H+ Sbjct: 11 LSARYEI-VDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS--EIQVLEHL 67 Query: 118 DHEN-IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL--SEEHCQYFLYQIL 174 + + R + + I +EL+ + I+ N L +H + YQI Sbjct: 68 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQIC 127 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNA-------------------NCDLKICDFGLARVTS 215 + + ++HS + H DLKP N+L N D+K+ DFG A T Sbjct: 128 KSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA--TY 185 Query: 216 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 + + + V TR YRAPE++L + ++ DVWS+GCI +E +FP D L + Sbjct: 186 DDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAM 244 Query: 276 LMELIGTPSEEELEFLNE---------------NAKRYI-RQLPPYPRQSITDKFPTVHP 319 + ++G + ++ + +A RY+ R P ++ H Sbjct: 245 MERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVE--HE 302 Query: 320 LAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 DLI+KML +DP +RIT+ +AL HP+ + L Sbjct: 303 RLFDLIQKMLEYDPAKRITLREALKHPFFDLL 334 >6FDY-U nrPDB Length = 276 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/288 (29%), Positives = 138/288 (47%), Gaps = 37/288 (12%) Query: 69 IGKGAYGIVCSA-MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G G Y V A +T E VAIK +A NK + L EI++L+ + H +IV ++D Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 78 Query: 128 IIPPPLRNAFNDVYIAYEL-MDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + +++Y+ E DL + I + + L E+ + F+ Q+ L+++H N+ Sbjct: 79 -----FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNIS 133 Query: 187 HRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H DLKP N+LL++ LK+ DFG A+ S D + Y APE++ Y A Sbjct: 134 HLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ-YDAR 192 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+WS+G I E + +P F R S ELE + + +LP Sbjct: 193 VDLWSMGVILYEALFGQPPFASR----------------SFSELE--EKIRSNRVIELPL 234 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 P S + DL++++L DP RRI+ D AHP+++ H Sbjct: 235 RPLLSRDCR---------DLLQRLLERDPSRRISFQDFFAHPWVDLEH 273 >5U6Y-A nrPDB Length = 461 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 134/286 (46%), Gaps = 37/286 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V + + A K I + D ++ RE ++ R + H NIV + D Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 67 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I + Y+ ++L+ +L + I + + SE + + QIL + + H V+H Sbjct: 68 ISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVH 122 Query: 188 RDLKPSNLLLNA---NCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + +K+ DFGLA V E + T Y +PE+L Y Sbjct: 123 RDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDPYGK 181 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ R +Q+ Sbjct: 182 PVDLWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYQQIK 215 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + ++ TV P A DLI KMLT +P +RIT +AL HP+++ Sbjct: 216 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >2VZ6-A nrPDB Length = 313 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 134/286 (46%), Gaps = 37/286 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V + + A K I + D ++ RE ++ R + H NIV + D Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 89 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I + Y+ ++L+ +L + I + + SE + + QIL + + H V+H Sbjct: 90 ISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVH 144 Query: 188 RDLKPSNLLLNA---NCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 RDLKP NLLL + +K+ DFGLA V E + T Y +PE+L Y Sbjct: 145 RDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDPYGK 203 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ R +Q+ Sbjct: 204 PVDLWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYQQIK 237 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + ++ TV P A DLI KMLT +P +RIT +AL HP+++ Sbjct: 238 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >3KK8-A nrPDB Length = 284 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 137/284 (48%), Gaps = 36/284 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V ++ T A K I + D ++ RE ++ R + H NIV + D Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDS 73 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +F+ Y+ ++L+ +L + I + + SE + + QIL + Y HS ++H Sbjct: 74 IQ---EESFH--YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVH 128 Query: 188 RDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 R+LKP NLLL + +K+ DFGLA ++S+ + T Y +PE +L Y+ Sbjct: 129 RNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE-VLKKDPYSKP 187 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+W+ G I L + L+G P F +E+ R Q+ Sbjct: 188 VDIWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYAQIKA 221 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + ++ TV P A LI+ MLT +P++RIT AL P++ Sbjct: 222 GAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3HZT-A nrPDB Length = 467 Score = 107 bits (268), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 89/289 (30%), Positives = 130/289 (44%), Gaps = 40/289 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 + +G GAYG V + T AIK I ++ ++ L E+ +L+ +DH NI+ Sbjct: 9 VKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 68 Query: 125 IRDIIPPPLRNAF--NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + RN + +VY EL D I+R Q SE + Q+L G Y+H Sbjct: 69 LYEFFEDK-RNYYLVMEVYRGGELFD---EIILR--QKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 183 ANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 N++HRDLKP NLLL + +KI DFGL+ M E + T +Y APE+L Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RK 180 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y DVWS G I L+ P F G + + E L K Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGG------------------QTDQEILKRVEKGKF 222 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 PP + V A L++ MLT++P +RI+ +AL HP++ Sbjct: 223 SFDPP--------DWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 89/289 (30%), Positives = 130/289 (44%), Gaps = 40/289 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 + +G GAYG V + T AIK I ++ ++ L E+ +L+ +DH NI+ Sbjct: 26 VKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 85 Query: 125 IRDIIPPPLRNAF--NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + RN + +VY EL D I+R Q SE + Q+L G Y+H Sbjct: 86 LYEFFEDK-RNYYLVMEVYRGGELFD---EIILR--QKFSEVDAAVIMKQVLSGTTYLHK 139 Query: 183 ANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 N++HRDLKP NLLL + +KI DFGL+ M E + T +Y APE+L Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RK 197 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y DVWS G I L+ P F G + + E L K Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGG------------------QTDQEILKRVEKGKF 239 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 PP + V A L++ MLT++P +RI+ +AL HP++ Sbjct: 240 SFDPP--------DWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >4YZB-A nrPDB Length = 491 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 99/345 (28%), Positives = 157/345 (45%), Gaps = 58/345 (16%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G PAA+ S ++ G F+Q++ + +YK + +GKG++G V Sbjct: 3 GSPAASKSDKLAATP---------GMFVQHSTAA----FSDRYKGQRV-LGKGSFGEVIL 48 Query: 80 AMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF- 137 + T + A+K I+ K D + L+E++LL+ +DH NI+ + + + F Sbjct: 49 CKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFED--KGYFY 106 Query: 138 --NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL 195 +VY EL D I S + SE + Q+L G+ Y+H ++HRDLKP NL Sbjct: 107 LVTEVYTGGELFDE-----IISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL 161 Query: 196 LLN---ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGC 252 LL + +++I DFGL+ + M + + T +Y APE+L + Y DVWS G Sbjct: 162 LLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGV 219 Query: 253 IFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK-RYIRQLPPYPRQSIT 311 I L+ P F G + E + L + K ++ LP + + Sbjct: 220 ILYILLSGCPPFNGAN------------------EFDILKKVEKGKFTFDLPQWKK---- 257 Query: 312 DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 V A DLI KML + P RI+ DAL H +L + +D Sbjct: 258 -----VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATD 297 >6QAU-A nrPDB Length = 280 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 68/211 (32%), Positives = 112/211 (53%), Gaps = 26/211 (12%) Query: 69 IGKGAYGIVCSAMNSE-TNESVAIKKIANAFDNKIDAKRTL----REIKLLRHMDHENIV 123 +G GA+ +V + + T+ VAIK I NK + ++ +EIK+L+ + HENIV Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSI-----NKKNLSKSQILLGKEIKILKELQHENIV 73 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 A+ D+ P N V++ E + DL +++ LSE+ + FL+QI ++ +HS Sbjct: 74 ALYDVQELP-----NSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128 Query: 183 ANVLHRDLKPSNLLLN---------ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 ++HRDLKP N+LL+ + +KI DFG AR + + + Y APE Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 +++ S Y A D+WS+G + + + KP F Sbjct: 189 VIM-SQHYDAKADLWSIGTVIYQCLVGKPPF 218 >3RAW-A nrPDB Length = 381 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 85/321 (26%), Positives = 144/321 (44%), Gaps = 45/321 (14%) Query: 69 IGKGAYGIVCSAMNSETNES-VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+G +G V ++ +S VA+K I N + A+ + +K ++ D EN Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLC-- 116 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANV 185 ++ N + IA+EL+ + + ++ N Q H ++ YQ+ L+++H + Sbjct: 117 VLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQL 176 Query: 186 LHRDLKPSNLLLN-------------------ANCDLKICDFGLARVTSESDFMTEYVVT 226 H DLKP N+L N +++ DFG A T + + T V T Sbjct: 177 THTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--TFDHEHHTTIVAT 234 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG-TPSE 285 R YR PE++L + DVWS+GCI E LF ++ L ++ +++G PS Sbjct: 235 RHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSH 293 Query: 286 ------EELEFL--------NENAKRYIRQ-LPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 ++ F N + RY+++ P + D H DL+ +ML Sbjct: 294 MIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLE--HVQLFDLMRRMLE 351 Query: 331 FDPRRRITVLDALAHPYLNSL 351 FDP +RIT+ +AL HP+ L Sbjct: 352 FDPAQRITLAEALLHPFFAGL 372 >2WO6-A nrPDB Length = 382 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 91/329 (27%), Positives = 153/329 (46%), Gaps = 53/329 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN--AFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IGKG++G V A + E VAIK I N AF N+ E++LL M+ + Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI-----EVRLLELMNKHDTEMKY 116 Query: 127 DIIPPPLRNAF-NDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHS- 182 I+ F N + + +E++ +L+ ++R+ + +S + F Q+ L ++ + Sbjct: 117 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 176 Query: 183 -ANVLHRDLKPSNLLLN--ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 +++H DLKP N+LL +KI DFG + + + +Y+ +R+YR+PE+LL Sbjct: 177 ELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY--QYIQSRFYRSPEVLLGMP 234 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 Y AID+WS+GCI +E+ +PLF G + V Q+ ++E++G P L+ A+++ Sbjct: 235 -YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD-QAPKARKFF 292 Query: 300 RQLP----------------------------------PYPRQSITDKFPTVHPLAI-DL 324 +LP P R++ L DL Sbjct: 293 EKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 352 Query: 325 IEKMLTFDPRRRITVLDALAHPYLNSLHD 353 I +ML +DP+ RI AL H + D Sbjct: 353 ILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >2W4O-A nrPDB Length = 349 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 82/287 (28%), Positives = 129/287 (44%), Gaps = 41/287 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+GA IV T + A+K + D KI RT EI +L + H NI+ +++I Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI--VRT--EIGVLLRLSHPNIIKLKEI 116 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 P ++ + EL+ +L I SE + QIL + Y+H ++H Sbjct: 117 FETP-----TEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 171 Query: 188 RDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 RDLKP NLL + LKI DFGL+++ M T Y APE+L + Y Sbjct: 172 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCA-YGPE 230 Query: 245 IDVWSVGCI-FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+WSVG I ++ L +P + R R ++ E F++ P Sbjct: 231 VDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC-------EYYFIS----------P 273 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + S+ K DL+ K++ DP++R+T AL HP++ Sbjct: 274 WWDEVSLNAK---------DLVRKLIVLDPKKRLTTFQALQHPWVTG 311 >4KS7-A nrPDB Length = 292 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 139/299 (46%), Gaps = 44/299 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIR 126 IG+G+ GIVC A + VA+K + D + +R L E+ ++R H N+V + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMM----DLRKQQRRELLFNEVVIMRDYQHFNVVEMY 86 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 ++++ E + I S L+EE +L+ L Y+H+ V+ Sbjct: 87 KSYL-----VGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 187 HRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRD+K ++LL + +K+ DFG A+++ + V T ++ APE +++ S Y + Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPE-VISRSLYATEV 200 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+G + +E++D +P + V A + +R PP Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQ-----------------------AMKRLRDSPP- 236 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 P+ + K V P+ D +E+ML DP+ R T + L HP+L + PEC +P Sbjct: 237 PKLKNSHK---VSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ----TGLPECLVPL 288 >5YKS-A nrPDB Length = 377 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 84/323 (26%), Positives = 146/323 (45%), Gaps = 42/323 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G + +V A + T E VA+K I + + +E++ ++ + H NIV + ++ Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 I + +Y+ EL D I++ + L+E+ + + QI+ + Y H +V+ Sbjct: 103 IDTQTK-----LYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVV 157 Query: 187 HRDLKPSNLLLNANCDL-KICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLKP N++ L K+ DFG + +T + Y APE+LL A+ Sbjct: 158 HRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAV 217 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+G I L+ +P F + L ++M+ T +P + Sbjct: 218 DIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT-------------------VPSH 258 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 + DLI +ML DP+RR ++ + HP+L + D S + IP Sbjct: 259 VSKECK-----------DLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPATKYNIPL- 305 Query: 366 FDFENHALSEEQMKELIYREALA 388 ++N LSEE+ +I R L Sbjct: 306 VSYKN--LSEEEHNSIIQRMVLG 326 >5XZW-A nrPDB Length = 471 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 135/299 (45%), Gaps = 55/299 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA+ V A+ T ++ A+K I+ +D RE+++L+ ++H IV Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDG--VTRELEVLQKLNHPRIVR--- 258 Query: 128 IIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 L+ + D Y +M+ DL + ++ A+ E+ + QIL +KYIHS Sbjct: 259 -----LKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 313 Query: 184 NVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS--- 238 + HRDLKP N+L+ + +KI DFGLA+V FM + T Y APE++ Sbjct: 314 GISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 373 Query: 239 ---------SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 ++Y++ +D+WS+GC+ ++ F G L + IG S E Sbjct: 374 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQ----LYKQIGRGSYHE-- 427 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P I+++ A D I+ +L DP R T AL HP++ Sbjct: 428 -------------GPLKDFRISEE-------ARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >4LFI-A nrPDB Length = 374 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 132/245 (53%), Gaps = 20/245 (8%) Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILR 175 H H NI+ + DII P+ + +E +D +I+ L++ +++++++L+ Sbjct: 129 HNGHANIIHLFDIIKDPISKT---PALVFEYVDNVDFRILYP--KLTDLEIRFYMFELLK 183 Query: 176 GLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 L Y HS ++HRD+KP N++++ N L++ D+GLA + V +R+++ PEL Sbjct: 184 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 243 Query: 235 LLNSSDYTAAIDVWSVGCIFMELM-DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L++ Y ++D+WS G + ++ R+P F G + QL +++++GT E+ E Sbjct: 244 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 303 Query: 294 --------NAKRYIRQLPPYPRQSITD--KFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 + +YIR+ P+ R I D K + + IDLI+ +L +D + R+T +A+ Sbjct: 304 ITLPREFYDMDQYIRK--PWHR-FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 360 Query: 344 AHPYL 348 HP+ Sbjct: 361 GHPWF 365 >3FME-A nrPDB Length = 290 Score = 104 bits (260), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 81/269 (30%), Positives = 134/269 (49%), Gaps = 26/269 (9%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-L 114 EV A PIM +G+GAYG+V + + + +A+K+I A N + KR L ++ + + Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 60 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL----HQIIRSNQALSEEHCQYFL 170 R +D V + R DV+I ELMDT L Q+I Q + E+ Sbjct: 61 RTVDCPFTVTFYGAL---FREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 171 YQILRGLKYIHSA-NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 I++ L+++HS +V+HRD+KPSN+L+NA +K+CDFG++ + + Y Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPY 175 Query: 230 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--- 283 APE + LN Y+ D+WS+G +EL + FP + L +++ P Sbjct: 176 MAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ 233 Query: 284 ------SEEELEFLNENAKRYIRQLPPYP 306 S E ++F ++ K+ ++ P YP Sbjct: 234 LPADKFSAEFVDFTSQCLKKNSKERPTYP 262 >3SOA-A nrPDB Length = 444 Score = 104 bits (260), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 82/286 (28%), Positives = 133/286 (46%), Gaps = 37/286 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA+ +V + + A I + D ++ RE ++ R + H NIV + D Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDS 78 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I + Y+ ++L+ +L + I + + SE + + QIL + + H V+H Sbjct: 79 ISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVH 133 Query: 188 RDLKPSNLLLNA---NCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 R+LKP NLLL + +K+ DFGLA V E + T Y +PE+L Y Sbjct: 134 RNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-RKDPYGK 192 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 +D+W+ G I L + L+G P F +E+ R +Q+ Sbjct: 193 PVDLWACGVI---------------------LYILLVGYPP-----FWDEDQHRLYQQIK 226 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + ++ TV P A DLI KMLT +P +RIT +AL HP+++ Sbjct: 227 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >2OU7-A nrPDB Length = 335 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 91/318 (28%), Positives = 143/318 (44%), Gaps = 41/318 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIRD 127 +GKG + +++T E A K + + K + + EI + R + H+++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 N F V++ EL L ++ + +AL+E +Y+L QI+ G +Y+H V+ Sbjct: 109 FFE---DNDF--VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLK NL LN + ++KI DFGLA +V + + T Y APE+L + ++ + Sbjct: 164 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 222 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+GCI L+ KP F E L E R + Sbjct: 223 DVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIKKNEYSI 260 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP-EC-TIP 363 P+ ++P+A LI+KML DP R T+ + L + S + + P C TIP Sbjct: 261 PKH--------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIP 312 Query: 364 FNFDFENHALSEEQMKEL 381 F +L K L Sbjct: 313 PRFSIAPSSLDPSNRKPL 330 >2Y7J-A nrPDB Length = 365 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 82/305 (26%), Positives = 140/305 (45%), Gaps = 45/305 (14%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN----KIDAKR--TLRE 110 E KY P + IG+G +V ++ T A+K + + +++ R T RE Sbjct: 91 EFYQKYDPKDV-IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRE 149 Query: 111 IKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQY 168 +LR + H +I+ + D + + +++ ++LM +L + ALSE+ + Sbjct: 150 THILRQVAGHPHIITLIDSY-----ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 + +L + ++H+ N++HRDLKP N+LL+ N +++ DFG + + + E T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 229 YRAPELLLNSSD-----YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 Y APE+L S D Y +D+W+ G I L+ P F R + LR++ME Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME----- 319 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 +Y P + +S T K DLI ++L DP R+T AL Sbjct: 320 ------------GQYQFSSPEWDDRSSTVK---------DLISRLLQVDPEARLTAEQAL 358 Query: 344 AHPYL 348 HP+ Sbjct: 359 QHPFF 363 >6FYV-A nrPDB Length = 337 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/321 (26%), Positives = 149/321 (46%), Gaps = 45/321 (14%) Query: 69 IGKGAYGIVCSAMNSETNE-SVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI-R 126 +G+GA+G V ++ + VA+K + N + +A R+ EI++L H++ + ++ R Sbjct: 22 LGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYR-EAARS--EIQVLEHLNSTDPNSVFR 78 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL--SEEHCQYFLYQILRGLKYIHSAN 184 + + V I +EL+ + I+ N L +H + YQI + + ++H Sbjct: 79 CVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNK 138 Query: 185 VLHRDLKPSNLLLNA-------------------NCDLKICDFGLARVTSESDFMTEYVV 225 + H DLKP N+L N D+K+ DFG A T + + + V Sbjct: 139 LTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--TYDDEHHSTLVS 196 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG---- 281 TR YRAPE++L + ++ DVWS+GCI +E +F D L ++ ++G Sbjct: 197 TRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQ 255 Query: 282 --TPSEEELEFLNEN---------AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 + ++ + N A RY+R+ P + H DL+ +ML Sbjct: 256 HMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLFDLVRRMLE 314 Query: 331 FDPRRRITVLDALAHPYLNSL 351 +DP +RIT+ +AL HP+ + L Sbjct: 315 YDPTQRITLDEALQHPFFDLL 335 >4CFH-A nrPDB Length = 493 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/317 (26%), Positives = 141/317 (44%), Gaps = 46/317 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P +D+++ E + +L I N L E+ + QIL G+ Y H V+ Sbjct: 101 VISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 155 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 215 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQL--RLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +WS G I L+ F DHV L ++ + TP ++LN Sbjct: 216 IWSSGVILYALLCGTLPFDD-DHVPTLFKKICDGIFYTP-----QYLN------------ 257 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 P I L++ ML DP +R T+ D H + D P+ P Sbjct: 258 --------------PSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPE 298 Query: 365 NFDFENHALSEEQMKEL 381 + + + + +E +KE+ Sbjct: 299 DPSYSSTMIDDEALKEV 315 >4FIE-A nrPDB Length = 423 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/335 (24%), Positives = 154/335 (45%), Gaps = 49/335 (14%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G P P P+ P E P +SH + + + + Y + IG+G+ GIVC Sbjct: 113 GMPEKPPGPRSPQRE--PQRVSHEQFRAALQLVVDPGDPRS-YLDNFIKIGEGSTGIVCI 169 Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIRDIIPPPLRNAF 137 A + + VA+KK+ D + +R L E+ ++R HEN+V + N++ Sbjct: 170 ATVRSSGKLVAVKKM----DLRKQQRRELLFNEVVIMRDYQHENVVE--------MYNSY 217 Query: 138 ---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSN 194 +++++ E ++ I ++ ++EE +L+ L +H+ V+HRD+K + Sbjct: 218 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 277 Query: 195 LLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCI 253 +LL + +K+ DFG A+V+ E V T ++ APE L++ Y +D+WS+G + Sbjct: 278 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIM 336 Query: 254 FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDK 313 +E++D +P + P + ++ + +N LPP Sbjct: 337 VIEMVDGEPPY---------------FNEPPLKAMKMIRDN-------LPPR-----LKN 369 Query: 314 FPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 V P ++++L DP +R T + L HP+L Sbjct: 370 LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4REW-A nrPDB Length = 540 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 141/317 (44%), Gaps = 46/317 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P +D+++ E + +L I N L E+ + QIL G+ Y H V+ Sbjct: 74 VISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 128 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 129 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 188 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQL--RLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +WS G I L+ F DHV L ++ + TP ++LN Sbjct: 189 IWSSGVILYALLCGTLPFDD-DHVPTLFKKICDGIFYTP-----QYLN------------ 230 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 P I L++ ML DP +R ++ D H + D P+ P Sbjct: 231 --------------PSVISLLKHMLQVDPMKRASIKDIREHEWFK-----QDLPKYLFPE 271 Query: 365 NFDFENHALSEEQMKEL 381 + + + + +E +KE+ Sbjct: 272 DPSYSSTMIDDEALKEV 288 >4B6L-A nrPDB Length = 281 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 72/206 (34%), Positives = 100/206 (48%), Gaps = 15/206 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMDHENIVAIRD 127 +GKG + A ++ET + A+K I + K + + L EI+L R + H +IV Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR--- 73 Query: 128 IIPPPLRNAFND---VYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + F D +YI EL L I ++ L E +Y+L QIL GLKY+H Sbjct: 74 -----FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR 128 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 +LHRDLK N + N +LK+ DFGL AR+ T Y APE+LL Sbjct: 129 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGP 188 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRD 268 A DVWS+GC+ L+ P F D Sbjct: 189 EA-DVWSLGCVMYTLLCGSPPFETAD 213 >6CMJ-A nrPDB Length = 321 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 77/294 (26%), Positives = 140/294 (47%), Gaps = 45/294 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVA---------IKKIANAFDNKIDAKRTLREIKLLRHMDH 119 IGKG+YG+V A N N A I++ + ++ +EI +L+ +DH Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 N+V + +++ P + +Y+ +EL++ + + + LSE+ +++ +++G++Y Sbjct: 102 PNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEY 158 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRWYRAPELLLNS 238 +H ++HRD+KPSNLL+ + +KI DFG++ SD ++ V T + APE L + Sbjct: 159 LHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSET 218 Query: 239 SDYTA--AIDVWSVGC-IFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + A+DVW++G ++ + + P R +M L + LEF Sbjct: 219 RKIFSGKALDVWAMGVTLYCFVFGQCPFMDER--------IMCLHSKIKSQALEF----- 265 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 P Q P + DLI +ML +P RI V + HP++ Sbjct: 266 ----------PDQ------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 303 >3KN6-A nrPDB Length = 325 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 139/297 (46%), Gaps = 36/297 (12%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIR 126 P+G+G++ I ++ ++N++ A+K I+ + T +EI L+ + H NIV + Sbjct: 18 PLGEGSFSICRKCVHKKSNQAFAVKIISKRME-----ANTQKEITALKLCEGHPNIVKLH 72 Query: 127 DIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 ++ L ++ EL++ +L + I+ + SE Y + +++ + ++H V Sbjct: 73 EVFHDQLH-----TFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 186 LHRDLKPSNLLL---NANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSDY 241 +HRDLKP NLL N N ++KI DFG AR+ ++ + T Y APE LLN + Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGY 186 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 + D+WS+G I ++ + F D +E++ + + F E K ++ Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQE 246 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP 358 A DLI+ +LT DP +R+ + + +L +S P Sbjct: 247 -------------------AKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP 284 >4JDH-A nrPDB Length = 346 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 83/335 (24%), Positives = 154/335 (45%), Gaps = 49/335 (14%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G P P P+ P E P +SH + + + + Y + IG+G+ GIVC Sbjct: 36 GMPEKPPGPRSPQRE--PQRVSHEQFRAALQLVVDPGDPRS-YLDNFIKIGEGSTGIVCI 92 Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIRDIIPPPLRNAF 137 A + + VA+KK+ D + +R L E+ ++R HEN+V + N++ Sbjct: 93 ATVRSSGKLVAVKKM----DLRKQQRRELLFNEVVIMRDYQHENVVE--------MYNSY 140 Query: 138 ---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSN 194 +++++ E ++ I ++ ++EE +L+ L +H+ V+HRD+K + Sbjct: 141 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDS 200 Query: 195 LLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCI 253 +LL + +K+ DFG A+V+ E V T ++ APE L++ Y +D+WS+G + Sbjct: 201 ILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIM 259 Query: 254 FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDK 313 +E++D +P + P + ++ + +N LPP Sbjct: 260 VIEMVDGEPPY---------------FNEPPLKAMKMIRDN-------LPPR-----LKN 292 Query: 314 FPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 V P ++++L DP +R T + L HP+L Sbjct: 293 LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >4RED-A nrPDB Length = 351 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 141/317 (44%), Gaps = 46/317 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T +VA+K + +D + REI+ L+ H +I+ + Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P +D+++ E + +L I N L E+ + QIL G+ Y H V+ Sbjct: 82 VISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 136 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQL--RLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +WS G I L+ F DHV L ++ + TP ++LN Sbjct: 197 IWSSGVILYALLCGTLPFDD-DHVPTLFKKICDGIFYTP-----QYLN------------ 238 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 P I L++ ML DP +R ++ D H + D P+ P Sbjct: 239 --------------PSVISLLKHMLQVDPMKRASIKDIREHEWFK-----QDLPKYLFPE 279 Query: 365 NFDFENHALSEEQMKEL 381 + + + +E +KE+ Sbjct: 280 DPSYSTTMIDDEALKEV 296 >4PDS-A nrPDB Length = 347 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 134/300 (44%), Gaps = 55/300 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA+ V A+ T ++ ++K I+ +D RE+++L+ ++H IV Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDG--VTRELEVLQKLNHPRIV---- 92 Query: 128 IIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 L+ + D Y +M+ DL + ++ A+ E+ + QIL +KYIHS Sbjct: 93 ----RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSM 148 Query: 184 NVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS--- 238 + HRDLKP N+L+ + +KI FGLA+V FM + T Y APE++ Sbjct: 149 GISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTS 208 Query: 239 ---------SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 ++Y++ +D+WS+GC+ ++ F G L + IG S E Sbjct: 209 VSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQ----LYKQIGRGSYHE-- 262 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 P I+++ A D I+ +L DP R T AL HP++ Sbjct: 263 -------------GPLKDFRISEE-------ARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >4J52-A nrPDB Length = 293 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 131/285 (45%), Gaps = 39/285 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIRD 127 +GKG + +++T E A K + + K + + EI + R + H+++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 N F V++ EL L ++ + +AL+E +Y+L QI+ G +Y+H V+ Sbjct: 82 FFED---NDF--VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 136 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLK NL LN + ++KI DFGLA +V + + T Y APE+L + ++ + Sbjct: 137 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 195 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+GCI L+ KP F E L E R + Sbjct: 196 DVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIKKNEYSI 233 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 P+ ++P+A LI+KML DP R T+ + L + S Sbjct: 234 PKH--------INPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >2JC6-A nrPDB Length = 334 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 81/285 (28%), Positives = 125/285 (43%), Gaps = 39/285 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G GA+ V A T + A+K I A K + EI +LR + HENIVA+ D Sbjct: 30 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN--EIAVLRKIKHENIVALED 87 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 I P N +Y+ +L+ +L I +E+ + Q+L + Y+H ++ Sbjct: 88 IYESP-----NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 142 Query: 187 HRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 HRDLKP NLL + + I DFGL+++ + D M+ T Y APE+L Y+ Sbjct: 143 HRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKP-YSK 201 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 A+D WS+G I L L G P F +EN + Q+ Sbjct: 202 AVDCWSIGVIAYIL---------------------LCGYPP-----FYDENDSKLFEQIL 235 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + + + + A D I ++ DP +R T A HP++ Sbjct: 236 KAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >2Q0N-A nrPDB Length = 301 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 73/286 (25%), Positives = 137/286 (47%), Gaps = 46/286 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIR 126 IG+G+ GIVC A + + VA+KK+ D + +R L E+ ++R HEN+V Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKM----DLRKQQRRELLFNEVVIMRDYQHENVVE-- 90 Query: 127 DIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + N++ +++++ E ++ I ++ ++EE +L+ L +H+ Sbjct: 91 ------MYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 144 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+K ++LL + +K+ DFG A+V+ E V T ++ APE L++ Y Sbjct: 145 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYG 203 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+WS+G + +E++D +P + P + ++ + +N L Sbjct: 204 PEVDIWSLGIMVIEMVDGEPPY---------------FNEPPLKAMKMIRDN-------L 241 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 PP V P ++++L DP +R T + L HP+L Sbjct: 242 PPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >3DB8-A nrPDB Length = 317 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 88/337 (26%), Positives = 146/337 (43%), Gaps = 69/337 (20%) Query: 22 PAAAPSPQMPGIENIPATLSH--GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 P +AP ++P + P T+ GRF+ F +E+T Sbjct: 23 PKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEIT-------------------- 62 Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIRDIIPPPLRNAFN 138 + +T E A K + + K K + EI + + +D+ ++V F Sbjct: 63 --DMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGF--------FE 112 Query: 139 D---VYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSN 194 D VY+ E+ L ++ + +A++E +YF+ Q ++G++Y+H+ V+HRDLK N Sbjct: 113 DDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGN 172 Query: 195 LLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCI 253 L LN + D+KI DFGLA ++ + + + T Y APE+L ++ +D+WS+GCI Sbjct: 173 LFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKG-HSFEVDIWSLGCI 231 Query: 254 FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDK 313 L+ KP F E L E R + PR Sbjct: 232 LYTLLVGKPPF----------------------ETSCLKETYIRIKKNEYSVPRH----- 264 Query: 314 FPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 ++P+A LI +ML DP R +V + L + S Sbjct: 265 ---INPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 >4XBR-A nrPDB Length = 366 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 73/286 (25%), Positives = 138/286 (48%), Gaps = 46/286 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIR 126 IG+G+ GIVC A + + VA+KK+ D + +R L E+ ++R HEN+V Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKM----DLRKQQRRELLFNEVVIMRDYQHENVVE-- 155 Query: 127 DIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + N++ +++++ E ++ I ++ ++EE +L+ L +H+ Sbjct: 156 ------MYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 209 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+K ++LL + +K+ DFG A+V+ E V T ++ APE L++ Y Sbjct: 210 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYG 268 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+WS+G + +E++D +P + P + ++ + +N L Sbjct: 269 PEVDIWSLGIMVIEMVDGEPPY---------------FNEPPLKAMKMIRDN-------L 306 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 PP + V P ++++L DP +R T + L HP+L Sbjct: 307 PPRLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >4FG9-A nrPDB Length = 320 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/285 (28%), Positives = 128/285 (44%), Gaps = 39/285 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G GA+ V A + T + VAIK IA A + K + EI +L + H NIVA+ D Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN--EIAVLHKIKHPNIVALDD 83 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 I + +Y+ +L+ +L I +E ++Q+L +KY+H ++ Sbjct: 84 IY-----ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 187 HRDLKPSNLL---LNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 HRDLKP NLL L+ + + I DFGL+++ ++ T Y APE+L Y+ Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKP-YSK 197 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 A+D WS+G I L L G P F +EN + Q+ Sbjct: 198 AVDCWSIGVIAYIL---------------------LCGYPP-----FYDENDAKLFEQIL 231 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + + + + A D I ++ DP +R T AL HP++ Sbjct: 232 KAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >4CZT-A nrPDB Length = 464 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/196 (33%), Positives = 99/196 (50%), Gaps = 12/196 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G+G + V A N E ++VAIK I NK+ A + REI ++ + H N++ + Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIRMF 77 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 +++ + +Y E + +L I SN L E+ + + Q++ + Y HS V Sbjct: 78 EVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGV 132 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARV---TSESDFMTEYVVTRWYRAPELLLNSSDYT 242 HRDLKP NLLL+AN LK+ DFGL+ + E + T Y APE++ N Sbjct: 133 YHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDG 192 Query: 243 AAIDVWSVGCIFMELM 258 A D+WS G I LM Sbjct: 193 AKADLWSCGVILFVLM 208 >3IS5-A nrPDB Length = 285 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 131/289 (45%), Gaps = 43/289 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA+G V + IK I N +++ ++ EI++L+ +DH NI+ I ++ Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTI-NKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEV 88 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRS---NQALSEEHCQYFLYQILRGLKYIHSA 183 ++++YI E + L +I+ + +ALSE + + Q++ L Y HS Sbjct: 89 F-----EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQ 143 Query: 184 NVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 +V+H+DLKP N+L + + +KI DFGLA + + T T Y APE+ D Sbjct: 144 HVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF--KRD 201 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 T D+WS G + L L + GT EE ++ Sbjct: 202 VTFKCDIWSAGVVMYFL---------------LTGCLPFTGTSLEE------------VQ 234 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 Q Y + + + P A+DL+++MLT DP RR + L H + Sbjct: 235 QKATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >4CQG-A nrPDB Length = 331 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 94/334 (28%), Positives = 146/334 (43%), Gaps = 49/334 (14%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDH 119 KY IG G + V A + T E VAIK + NA + D R EI L+ + H Sbjct: 9 KYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLRH 66 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 ++I + ++ N +++ E +L I S LSEE + QIL + Sbjct: 67 QHICQLYHVLETK-----NKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVA 121 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDF-MTEYVVTRWYRAPELLL 236 Y+HS HRDLKP NLL + N LK+ DFGL A+ D+ + E + Y APEL+ Sbjct: 122 YVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQ 181 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 S + DVWS+G + LM P D + + L + Sbjct: 182 GKSYLGSEADVWSMGILLYVLM--CGFLPFDD-----------------DNVMALYKKIM 222 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 R ++P + + P +I L+++ML DP++RI++ + L HP++ + Sbjct: 223 RGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 Query: 357 EPECTIPFNFDFEN--------HALSEEQMKELI 382 E + P E+ H S + M++LI Sbjct: 272 EWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLI 305 >4NIF-A nrPDB Length = 333 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 87/291 (29%), Positives = 133/291 (45%), Gaps = 48/291 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G+Y ++ TN A+K I + K D + EI LLR+ H NI+ ++D+ Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKS---KRDPSEEI-EI-LLRYGQHPNIITLKDV 70 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + VY+ ELM L +I+R + SE + L+ I + ++Y+HS V+ Sbjct: 71 Y-----DDGKHVYLVTELMRGGELLDKILR-QKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 187 HRDLKPSNLLL-----NANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSD 240 HRDLKPSN+L N C L+ICDFG A+ + +E+ + T + APE +L Sbjct: 125 HRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAENGLLMTPCYTANFVAPE-VLKRQG 182 Query: 241 YTAAIDVWSVGC-IFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE-NAKRY 298 Y D+WS+G ++ L P G PS+ E L + ++ Sbjct: 183 YDEGCDIWSLGILLYTMLAGYTPFANG----------------PSDTPEEILTRIGSGKF 226 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + TV A DL+ KML DP +R+T L HP++ Sbjct: 227 TLS---------GGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 >5J5T-A nrPDB Length = 370 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 151/338 (44%), Gaps = 28/338 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG G YG V A N T E AIK I + D +EI +++ H NIVA Sbjct: 9 IQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKHPNIVAY 66 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 LR + ++I E L I LSE Y + L+GL Y+HS Sbjct: 67 ---FGSYLRR--DKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPEL--LLNSSDY 241 +HRD+K +N+LL N +K+ DFG+ A++T+ ++ T ++ APE+ + Y Sbjct: 122 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGY 181 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT-----PSEEELEFLNENAK 296 D+W+VG +EL + +P P D +H +R L + + ++++++ N Sbjct: 182 NQLCDLWAVGITAIELAELQP--PMFD-LHPMRALFLMTKSNFQPPKLKDKMKWSNSFHH 238 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 L P++ T + HP + + L I +LD + +P ++ HD D Sbjct: 239 FVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLA------IELLDKVNNPDHSTYHDFDD 292 Query: 357 ---EPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 EP +P + + EE+ + I + F+P Sbjct: 293 DDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDP 330 >1PHK-A nrPDB Length = 298 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 131/295 (44%), Gaps = 45/295 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-------TLREIKLLRHMD-HE 120 +G+G +V ++ T + A+K I A+ TL+E+ +LR + H Sbjct: 25 LGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHP 84 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 NI+ ++D N F ++ ++LM +L + LSE+ + + +L + Sbjct: 85 NIIQLKDTYET---NTF--FFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICA 139 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 +H N++HRDLKP N+LL+ + ++K+ DFG + + + E T Y APE++ Sbjct: 140 LHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSM 199 Query: 237 --NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 N Y +D+WS G I L+ P F R + LR++M Sbjct: 200 NDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM----------------- 242 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + Y P + S T K DL+ + L P++R T +ALAHP+ Sbjct: 243 SGNYQFGSPEWDDYSDTVK---------DLVSRFLVVQPQKRYTAEEALAHPFFQ 288 >3F3Z-A nrPDB Length = 277 Score = 98.2 bits (243), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 81/284 (28%), Positives = 123/284 (43%), Gaps = 39/284 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G++G V A+ T A KKI F +D R +EI++++ +DH NI+ + + Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD--RFKQEIEIMKSLDHPNIIRLYET 74 Query: 129 IPPPLRNAFNDVYIAYEL-MDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 D+Y+ EL +L + + + E + +L + Y H NV H Sbjct: 75 F-----EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 188 RDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 RDLKP N L + + LK+ DFGLA M V T +Y +P++L Y Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL--EGLYGPE 187 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 D WS G + L+ P F + + E GT + E ++LN Sbjct: 188 CDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIRE--GTFTFPEKDWLN------------ 233 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 V P A LI ++LT P++RIT L AL H + Sbjct: 234 ------------VSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265 >3COM-A nrPDB Length = 314 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 136/292 (46%), Gaps = 44/292 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G+YG V A++ ET + VAIK++ + D + ++EI +++ D ++V Sbjct: 37 LGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHVVKYYGS 92 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +N D++I E + IIR N+ L+E+ L L+GL+Y+H + Sbjct: 93 Y---FKN--TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKI 147 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV-TRWYRAPELLLNSSDYTAAI 245 HRD+K N+LLN K+ DFG+A +++ V+ T ++ APE++ Y Sbjct: 148 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGYNCVA 206 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+G +E+ + KP + +H +R + + P PP Sbjct: 207 DIWSLGITAIEMAEGKPPYA---DIHPMRAIFMIPTNP-------------------PPT 244 Query: 306 PRQS--ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 R+ +D F D +++ L P +R T L HP++ S +S Sbjct: 245 FRKPELWSDNF-------TDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVS 289 >4WNO-A nrPDB Length = 287 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 72/223 (32%), Positives = 111/223 (49%), Gaps = 23/223 (10%) Query: 69 IGKGAYGIVCSAMNSETNE-SVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAI 125 IG GA+ +V + ++ VA+K I + +TL +EIK+L+ + HENIVA+ Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINK---KNLAKSQTLLGKEIKILKELKHENIVAL 82 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 D + N VY+ E + DL + + + LSE+ + FL QI ++ +HS Sbjct: 83 YD-----FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG 137 Query: 185 VLHRDLKPSNLLLN------ANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 ++HRDLKP N+LL+ AN + +KI DFG AR + + Y APE++ Sbjct: 138 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 197 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 + S Y D+WS+G I + + K F LRL E Sbjct: 198 M-SQHYDGKADLWSIGTIVYQCLTGKAPFQASS-PQDLRLFYE 238 >4JG6-A nrPDB Length = 355 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/293 (29%), Positives = 140/293 (47%), Gaps = 54/293 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK-LLRHMDHENIVAIRD 127 IG G+Y + ++ TN A+K I + + EI+ LLR+ H NI+ ++D Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKS------KRDPTEEIEILLRYGQHPNIITLKD 96 Query: 128 IIPPPLRNAFND---VYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + ++D VY+ ELM L +I+R + SE L+ I + ++Y+H+ Sbjct: 97 V--------YDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLFTITKTVEYLHA 147 Query: 183 ANVLHRDLKPSNLLL---NANCD-LKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLN 237 V+HRDLKPSN+L + N + ++ICDFG A+ + +E+ + T + APE +L Sbjct: 148 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPE-VLE 206 Query: 238 SSDYTAAIDVWSVGC-IFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 Y AA D+WS+G ++ L P G D TP EE L + Sbjct: 207 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD------------TP-EEILARIGSG-- 251 Query: 297 RYIRQLPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + S++ + +V A DL+ KML DP +R+T L HP++ Sbjct: 252 ----------KFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >4D28-A nrPDB Length = 446 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 61/194 (31%), Positives = 104/194 (53%), Gaps = 10/194 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANA--FDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG+G + V A N++T ++VAIK +A + N++ + REI +++ + H NIV + Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRHPNIVRLY 75 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 +++ + +YI E + +L I L E+ + + Q++ + + HS V Sbjct: 76 EVLASK-----SKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGV 130 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLNSSDYTAA 244 HRDLKP NLLL+ N +LK+ DFGL+ + E + + + T Y APE+L +A Sbjct: 131 YHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSA 190 Query: 245 IDVWSVGCIFMELM 258 D+WS G I ++ Sbjct: 191 ADIWSCGVILFVIL 204 >3Q5I-A nrPDB Length = 504 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 46/298 (15%) Query: 65 PIMPIGKGAYG--IVCSAMNSETNESVAIKKIAN------AFDNKIDAK---RTLREIKL 113 + +G GAYG ++C N + +++ + K + + DNK K EI L Sbjct: 40 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISL 99 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQI 173 L+ +DH NI+ + D+ + F V YE +L + I + E + QI Sbjct: 100 LKSLDHPNIIKLFDVFED--KKYFYLVTEFYE--GGELFEQIINRHKFDECDAANIMKQI 155 Query: 174 LRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 L G+ Y+H N++HRD+KP N+LL N+ ++KI DFGL+ S+ + + + T +Y Sbjct: 156 LSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYI 215 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE+L Y DVWS G I L+ P F G Sbjct: 216 APEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGG------------------------ 249 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 +N + I+++ + + + A +LI+ MLT+D +R T +AL ++ Sbjct: 250 --QNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWI 305 >5YV8-A nrPDB Length = 298 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 141/309 (45%), Gaps = 60/309 (19%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA------------------------NAFDNKIDA 104 IGKG+YG+V A N N A+K ++ + Sbjct: 21 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 80 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 ++ +EI +L+ +DH N+V + +++ P + +Y+ +EL++ + + + LSE+ Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVPTLKPLSED 137 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEY 223 +++ +++G++Y+H ++HRD+KPSNLL+ + +KI DFG++ SD ++ Sbjct: 138 QARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 197 Query: 224 VVTRWYRAPELLLNSSDYTA--AIDVWSVGC-IFMELMDRKPLFPGRDHVHQLRLLMELI 280 V T + APE L + + A+DVW++G ++ + + P R +M L Sbjct: 198 VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDER--------IMCLH 249 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 + LEF P Q P + DLI +ML +P RI V Sbjct: 250 SKIKSQALEF---------------PDQ------PDIAEDLKDLITRMLDKNPESRIVVP 288 Query: 341 DALAHPYLN 349 + HP++ Sbjct: 289 EIKLHPWVT 297 >5UNP-A nrPDB Length = 369 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 83/326 (25%), Positives = 150/326 (46%), Gaps = 49/326 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNES-VAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN--- 121 + +G+G +G V ++ + VA+K I N K A+ + ++ + D +N Sbjct: 39 VSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNL 98 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSE--EHCQYFLYQILRGLKY 179 V + D + + I++EL+ ++ N L ++ +Q+ + +K+ Sbjct: 99 CVQMFDWF-----DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKF 153 Query: 180 IHSANVLHRDLKPSNLL-LNANCDL------------------KICDFGLARVTSESDFM 220 +H + H DLKP N+L +N++ +L ++ DFG A T + + Sbjct: 154 LHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA--TFDHEHH 211 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 + V TR YRAPE++L ++ DVWS+GCI E LF D+ L ++ ++ Sbjct: 212 STIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERIL 270 Query: 281 G-------TPSEEELEFL--------NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 G + ++ F N +A RY+R+ R+ +T + H L DLI Sbjct: 271 GPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL-FDLI 329 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSL 351 E ML ++P +R+T+ +AL HP+ L Sbjct: 330 ESMLEYEPAKRLTLGEALQHPFFARL 355 >5JZN-A nrPDB Length = 280 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 133/302 (44%), Gaps = 49/302 (16%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLR 115 +T +YK IG G + +V + T A+K I + K K + E+ +LR Sbjct: 17 ITERYKVG-RTIGDGNFAVVKECVERSTAREYALKIIKKS---KCRGKEHMIQNEVSILR 72 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H NIV + + + P ++Y+ EL+ DL I S +E LY + Sbjct: 73 RVKHPNIVLLIEEMDVP-----TELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLA 127 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCD----LKICDFGLARVTSESDFMTEYVVTRWYR 230 +KY+HS N++HRD+KP NLL+ + D LK+ DFGLA + + T Y Sbjct: 128 SAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTV--CGTPTYV 185 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL---RLLMELIGTPSEEE 287 APE++ + Y +D+W+ G I L+ P F G ++ ++LM + PS Sbjct: 186 APEIIAETG-YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPS--- 241 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 347 PY + V A +LI ML D +R + + L HP+ Sbjct: 242 ----------------PY--------WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277 Query: 348 LN 349 +N Sbjct: 278 VN 279 >2BRG-A nrPDB Length = 297 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 99/198 (50%), Gaps = 12/198 (6%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVA 124 + +G+GAYG V A+N T E+VA+K + +D ++ EI + + ++HEN+V Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVD--MKRAVDCPENIKKEICINKMLNHENVVK 69 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 R N Y+ E +L I + + E Q F +Q++ G+ Y+H Sbjct: 70 FYG-----HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI 124 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSSD 240 + HRD+KP NLLL+ +LKI DFGLA R + + + T Y APELL Sbjct: 125 GITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184 Query: 241 YTAAIDVWSVGCIFMELM 258 + +DVWS G + ++ Sbjct: 185 HAEPVDVWSCGIVLTAML 202 >6E2O-A nrPDB Length = 295 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 65/202 (32%), Positives = 105/202 (51%), Gaps = 12/202 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG YGIV + + +AIK+I D++ ++ EI L +H+ H+NIV Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPER-DSRY-SQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA---LSEEHCQYFLYQILRGLKYIHSANV 185 N F +++ ++ L ++RS +E+ ++ QIL GLKY+H + Sbjct: 88 FS---ENGFIKIFME-QVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 143 Query: 186 LHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTE-YVVTRWYRAPELLLNS-SDYT 242 +HRD+K N+L+N LKI DFG ++ + + TE + T Y APE++ Y Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYG 203 Query: 243 AAIDVWSVGCIFMELMDRKPLF 264 A D+WS+GC +E+ KP F Sbjct: 204 KAADIWSLGCTIIEMATGKPPF 225 >2J90-A nrPDB Length = 304 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 75/293 (25%), Positives = 125/293 (42%), Gaps = 43/293 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G + IV T + A K I ++ + + RE+ +LR + H NI+ Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIIT 93 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + DI DV + EL+ +L + ++L+E+ FL QIL G+ Y+HS Sbjct: 94 LHDIFENK-----TDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSK 148 Query: 184 NVLHRDLKPSN-LLLNANC---DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 + H DLKP N +LL+ N +K+ DFG+A + T + APE ++N Sbjct: 149 RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE-IVNYE 207 Query: 240 DYTAAIDVWSVGCI-FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 D+WS+G I ++ L P FL E + Sbjct: 208 PLGLEADMWSIGVITYILLSGASP---------------------------FLGETKQET 240 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + + + F LA D I ++L DP+RR+T+ +L H ++ ++ Sbjct: 241 LTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAI 293 >4KIK-B nrPDB Length = 677 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 68/207 (32%), Positives = 101/207 (48%), Gaps = 13/207 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V N ET E +AIK+ + + +R EI+++R + H N+VA RD+ Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPR-NRERWCLEIQIMRRLTHPNVVAARDV 85 Query: 129 IPPPLRN-AFNDV-YIAYE-LMDTDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHS 182 P ++N A ND+ +A E DL + + + L E L I L+Y+H Sbjct: 86 -PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHE 144 Query: 183 ANVLHRDLKPSNLLLNANCDL---KICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 ++HRDLKP N++L KI D G A+ + T +V T Y APE LL Sbjct: 145 NRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE-LLEQQ 203 Query: 240 DYTAAIDVWSVGCIFMELMDR-KPLFP 265 YT +D WS G + E + +P P Sbjct: 204 KYTVTVDYWSFGTLAFECITGFRPFLP 230 >3GUB-A nrPDB Length = 295 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 126/292 (43%), Gaps = 45/292 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G + +V T A K I + + + RE+ +L+ + H N++ Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVIT 78 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + ++ N + + I + +L + ++L+EE FL QIL G+ Y+HS Sbjct: 79 LHEV----YENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQ 134 Query: 185 VLHRDLKPSN-LLLNANC---DLKICDFGLARVTSESDFMTEY---VVTRWYRAPELLLN 237 + H DLKP N +LL+ N +KI DFGLA + DF E+ T + APE++ N Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAH---KIDFGNEFKNIFGTPEFVAPEIV-N 190 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 D+WS+G I L+ F G E + S EF +E Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFLGDTK-------QETLANVSAVNYEFEDEY--- 240 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 F LA D I ++L DP++R+T+ D+L HP++ Sbjct: 241 ----------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >4CFF-A nrPDB Length = 571 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/317 (24%), Positives = 135/317 (42%), Gaps = 46/317 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P D ++ E + +L I + + E + QIL + Y H V+ Sbjct: 101 VISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 155 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 215 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--SEEELEFLNENAKRYIRQLPP 304 +WS G I L L GT +E + L + + + +P Sbjct: 216 IWSCGVILYAL---------------------LCGTLPFDDEHVPTLFKKIRGGVFYIPE 254 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 Y +S+ L+ ML DP +R T+ D H + D P P Sbjct: 255 YLNRSVA-----------TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPE 298 Query: 365 NFDFENHALSEEQMKEL 381 + ++ + + +E +KE+ Sbjct: 299 DPSYDANVIDDEAVKEV 315 >6CCF-A nrPDB Length = 290 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 138/310 (44%), Gaps = 60/310 (19%) Query: 69 IGKGAYGIVCSAMNSETNESVAI----------------------KKIANAFDNK--IDA 104 IGKGAYG+V A N + A+ + A K + Sbjct: 13 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPL 72 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 +R +EI +L+ +DH N+V + +++ P A +++Y+ ++L+ + ++ SEE Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDP---AEDNLYLVFDLLRKGPVMEVPCDKPFSEE 129 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-MTEY 223 + +L ++ GL+Y+H ++HRD+KPSNLLL + +KI DFG++ +D ++ Sbjct: 130 QARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSST 189 Query: 224 VVTRWYRAPELLLNSSDYTA--AIDVWSVGC-IFMELMDRKPLFPGRDHVHQLRLLMELI 280 T + APE + +S + A+DVW+ G ++ + + P ++ E + Sbjct: 190 AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPV 249 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 P E E ++E K DLI KML +P RI V Sbjct: 250 VFPEEPE---ISEELK--------------------------DLILKMLDKNPETRIGVP 280 Query: 341 DALAHPYLNS 350 D HP++ Sbjct: 281 DIKLHPWVTK 290 >3QA8-A nrPDB Length = 676 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 104/206 (50%), Gaps = 11/206 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V ++ +T E VAIK+ K + +R EI++++ ++H N+V+ R++ Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPK-NRERWCLEIQIMKKLNHPNVVSAREV 80 Query: 129 IPPPLRNAFNDV-YIAYELMDT-DLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 + A ND+ +A E + DL + + + L E + L I L+Y+H Sbjct: 81 PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHEN 140 Query: 184 NVLHRDLKPSNLLLNANCDL---KICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 ++HRDLKP N++L KI D G A+ + + TE+V T Y APE LL Sbjct: 141 RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE-LLEQKK 199 Query: 241 YTAAIDVWSVGCIFMELMDR-KPLFP 265 YT +D WS G + E + +P P Sbjct: 200 YTVTVDYWSFGTLAFECITGFRPFLP 225 >5EZV-A nrPDB Length = 560 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/317 (24%), Positives = 135/317 (42%), Gaps = 46/317 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P D ++ E + +L I + + E + QIL + Y H V+ Sbjct: 96 VISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 150 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 151 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 210 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--SEEELEFLNENAKRYIRQLPP 304 +WS G I L L GT +E + L + + + +P Sbjct: 211 IWSCGVILYAL---------------------LCGTLPFDDEHVPTLFKKIRGGVFYIPE 249 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 Y +S+ L+ ML DP +R T+ D H + D P P Sbjct: 250 YLNRSVA-----------TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPE 293 Query: 365 NFDFENHALSEEQMKEL 381 + ++ + + +E +KE+ Sbjct: 294 DPSYDANVIDDEAVKEV 310 >5TQX-A nrPDB Length = 655 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 98/198 (49%), Gaps = 11/198 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G VC + E + +AIK K + +R EI++++ ++H N+V D+ Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-NRERWCHEIQIMKKLNHANVVKACDV 74 Query: 129 IPPPLRNAFNDV-YIAYELMDT-DLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 P L +DV +A E DL +++ + L E L I G++Y+H Sbjct: 75 -PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 133 Query: 184 NVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 ++HRDLKP N++L KI D G A+ + + TE+V T Y APEL N Sbjct: 134 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFENKP- 192 Query: 241 YTAAIDVWSVGCIFMELM 258 YTA +D WS G + E + Sbjct: 193 YTATVDYWSFGTMVFECI 210 >4LG4-A nrPDB Length = 299 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 135/292 (46%), Gaps = 44/292 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G+YG V A++ E+ + VAIK++ + D + ++EI +++ D +V Sbjct: 19 LGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYVVKYYG- 73 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +N D++I E + IIR N+ L E+ L L+GL+Y+H + Sbjct: 74 --SYFKN--TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 129 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV-TRWYRAPELLLNSSDYTAAI 245 HR++K N+LLN K+ DFG+A +++ V+ T ++ APE ++ Y Sbjct: 130 HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE-VIQEIGYNCVA 188 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+G +E+ + KP + +H +R + + P PP Sbjct: 189 DIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNP-------------------PPT 226 Query: 306 PRQS--ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 R+ +D F D ++K L +P +R T L HP++ + +S Sbjct: 227 FRKPELWSDDF-------TDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVS 271 >5ES1-A nrPDB Length = 328 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 10/213 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG + V A + T VAIK I N ++ RE+++++ ++H NIV + ++ Sbjct: 23 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEV 82 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +Y+ E ++ + S+ + E+ + QI+ + Y H N++H Sbjct: 83 IETE-----KTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVH 137 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLK NLLL+A ++KI DFG + + + + + Y APEL +D+ Sbjct: 138 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDI 197 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 WS+G I L+ F G H L+ L E + Sbjct: 198 WSLGVILYTLVSGSLPFDG----HNLKELRERV 226 >2QNJ-A nrPDB Length = 328 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 79/334 (23%), Positives = 142/334 (42%), Gaps = 50/334 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG + V A + T VAIK I N ++ RE+++++ ++H NIV + ++ Sbjct: 20 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 79 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +Y+ E ++ + ++ + E+ + QI+ ++Y H ++H Sbjct: 80 IETE-----KTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVH 134 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLK NLLL+A+ ++KI DFG + + + + + Y APEL +DV Sbjct: 135 RDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDV 194 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 WS+G I L+ F G++ L E +R +R P Sbjct: 195 WSLGVILYTLVSGSLPFDGQN----------------------LKELRERVLRGKYRIPF 232 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH-------------DI 354 TD +L+++ L +P +R T+ + ++N+ H DI Sbjct: 233 YMSTD--------CENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDI 284 Query: 355 SDEPECTIPFNFDFENHALSEEQMKELIYREALA 388 SD+ I + + +E + ++ Y E A Sbjct: 285 SDQKRIDIMVGMGYSQEEI-QESLSKMKYDEITA 317 >5WAX-A nrPDB Length = 310 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 83/283 (29%), Positives = 128/283 (45%), Gaps = 35/283 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G +G+ N + VA+K I KID + REI R + H NI+ +++ Sbjct: 19 IGSGNFGVARLMRNRADGQLVAVKYIERG--EKID-ENVQREIINHRSLRHPNIIRFKEV 75 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 I P A Y + +L + I + SE+ ++F Q++ G+ Y HS V HR Sbjct: 76 ILTPTHLAIVMEYAS----GGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHR 131 Query: 189 DLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 DLK N LL+ + LKICDFG ++ + V T Y APE+LL D Sbjct: 132 DLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 191 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT-PSEEELEFLNENAKRYIRQLPPY 305 VWS G + L + L+G P E+ E +N ++ I+++ Sbjct: 192 VWSCG---------------------VTLYVMLVGAYPFEDPDE--PKNFRKTIQRILGV 228 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + SI D + + P DLI ++ +P RIT+ + HP+ Sbjct: 229 -QYSIPD-YVHISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >1U5R-A nrPDB Length = 348 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 107/198 (54%), Gaps = 12/198 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 IG G++G V A + +E VAIKK++ + + + ++E++ L+ + H N + R Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 121 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 LR + + Y L +DL ++ + L E + L+GL Y+HS N++ Sbjct: 122 CY---LREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTHGALQGLAYLHSHNMI 176 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--NSSDYTAA 244 HRD+K N+LL+ +K+ DFG A + + ++ +V T ++ APE++L + Y Sbjct: 177 HRDVKAGNILLSEPGLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGK 233 Query: 245 IDVWSVGCIFMELMDRKP 262 +DVWS+G +EL +RKP Sbjct: 234 VDVWSLGITCIELAERKP 251 >4D2V-A nrPDB Length = 356 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 133/299 (44%), Gaps = 39/299 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G + V A + T E VAIK I + D R EI+ L+++ H++I + + Sbjct: 37 IGTGGFAKVKLACHILTGEMVAIK-IMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHV 95 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 + N +++ E +L I S LSEE + QI+ + Y+HS H Sbjct: 96 LETA-----NKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 188 RDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRW-YRAPELLLNSSDYTAAI 245 RDLKP NLL + LK+ DFGL A+ D+ + Y APEL+ S + Sbjct: 151 RDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSEA 210 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+G + LM G L F ++ A + ++ Sbjct: 211 DVWSMGILLYVLM---------------------CGF-----LPFDDDTAAALVAKI--- 241 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPF 364 + D + P +I L+++ML DP++RI++ + L HP++ ++ E + PF Sbjct: 242 -MRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPF 299 >1KOB-A nrPDB Length = 387 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 123/291 (42%), Gaps = 44/291 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA+G+V + T K I + +D EI ++ + H ++ + D Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKNEISIMNQLHHPKLINLHD- 115 Query: 129 IPPPLRNAFNDVY---IAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 AF D Y + E + +I + +SE ++ Q GLK++H Sbjct: 116 -------AFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 184 NVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 +++H D+KP N++ +KI DFGLA + + + T + APE++ + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREPV 227 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 D+W++G + L+ F G D + L +N KR + Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETL-------------------QNVKRCDWE 268 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 D F +V P A D I+ +L +PR+R+TV DAL HP+L H Sbjct: 269 FD-------EDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >4C0T-A nrPDB Length = 974 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/307 (26%), Positives = 134/307 (43%), Gaps = 71/307 (23%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G+Y V A + T + A+K + D + ++E K +++++ E R Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVL--------DKRHIIKE-KKVKYVNIEKHALNR-- 322 Query: 129 IPPPLRNAFNDVYIAYELMDTD-------------LHQIIRSNQALSEEHCQYFLYQILR 175 L N + + + D D L +I+ L+EE ++F QIL Sbjct: 323 ----LSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILD 378 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----------YVV 225 +KY+H V+HRDLKP N+LL+ ++I DFG AR+ + + +E +V Sbjct: 379 AIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVG 438 Query: 226 TRWYRAPELLLNSSDYTAA-IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 T Y +PELL N Y DVW+ GCI +++ KP F + + + Sbjct: 439 TAEYVSPELLENK--YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKIT------- 489 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 +L+F + + FPT+ DLI+K+L P RR T+ + Sbjct: 490 --KLQF------------------AFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQK 526 Query: 345 HPYLNSL 351 H + S+ Sbjct: 527 HYFFQSV 533 >1ZWS-A nrPDB Length = 288 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 124/290 (42%), Gaps = 41/290 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G + IV T A K I + A + + RE+ +LR + H N++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + D+ DV + EL+ +L + ++LSEE F+ QIL G+ Y+H+ Sbjct: 80 LHDVYENR-----TDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 184 NVLHRDLKPSN-LLLNANC---DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 + H DLKP N +LL+ N +K+ DFGLA + T + APE ++N Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYE 193 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 D+WS+G I L+ F +G +E L + + + Sbjct: 194 PLGLEADMWSIGVITYILLSGASPF---------------LGDTKQETLANITSVSYDFD 238 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + F LA D I K+L + R+R+T+ +AL HP++ Sbjct: 239 EEF-----------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >3D2K-A nrPDB Length = 272 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 129/288 (44%), Gaps = 45/288 (15%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIR 126 P+GKG +G V A ++ +A+K + K + LR E+++ H+ H NI+ Sbjct: 19 PLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILR-- 76 Query: 127 DIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALS---EEHCQYFLYQILRGLKYIHS 182 L F+D Y +++ L + R Q LS E+ ++ ++ L Y HS Sbjct: 77 ------LYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHS 130 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+KP NLLL +N +LKI DFG + V + S T T Y PE ++ + Sbjct: 131 KRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEGRMHD 188 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+WS+G + E + P F + R + + T +F+ E A+ Sbjct: 189 EKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP----DFVTEGAR------ 238 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 DLI ++L + +R+T+ + L HP++ + Sbjct: 239 --------------------DLISRLLKHNASQRLTLAEVLEHPWIKA 266 >6AO5-A nrPDB Length = 362 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 135/292 (46%), Gaps = 44/292 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G+YG V A++ E+ + VAIK++ + D + ++EI +++ D +V Sbjct: 18 LGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYVVKYYGS 73 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +N D++I E + IIR N+ L E+ L L+GL+Y+H + Sbjct: 74 Y---FKN--TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 128 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV-TRWYRAPELLLNSSDYTAAI 245 HR++K N+LLN K+ DFG+A +++ V+ T ++ APE ++ Y Sbjct: 129 HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE-VIQEIGYNCVA 187 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+WS+G +E+ + KP + +H +R + + P PP Sbjct: 188 DIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNP-------------------PPT 225 Query: 306 PRQS--ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 R+ +D F D ++K L +P +R T L HP++ + +S Sbjct: 226 FRKPELWSDDF-------TDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVS 270 >4I6B-A nrPDB Length = 308 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 105/203 (51%), Gaps = 17/203 (8%) Query: 69 IGKGAYGIVCSAMNSETNESV-AIKKIANAFDNKIDAKRTL-REIKLLRHMDHENIVAIR 126 +GKG + C M TN V A K I ++ +K + + +EI+L R + H+++V Sbjct: 36 LGKGGFA-KCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQ-- 92 Query: 127 DIIPPPLRNAFND---VYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + F D +YI E + I+++ + L+E +Y+L QI+ GLKY+H Sbjct: 93 ------FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHE 146 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 +LHRDLK N +N + +LK+ DFGL AR+ T Y +PE +LN + Sbjct: 147 QEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE-VLNKQGH 205 Query: 242 TAAIDVWSVGCIFMELMDRKPLF 264 A D+W++GC+ ++ +P F Sbjct: 206 GAESDIWALGCVMYTMLLGRPPF 228 >2A27-A nrPDB Length = 321 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 123/290 (42%), Gaps = 41/290 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G + IV T A K I + A + + RE+ +LR + H N++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + D+ DV + EL+ +L + ++LSEE F+ QIL G+ Y+H+ Sbjct: 80 LHDVYENR-----TDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 184 NVLHRDLKPSN-LLLNANC---DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 + H DLKP N +LL+ N +K+ DFGLA + T + APE ++N Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYE 193 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 D+WS+G I L+ +P FL + + + Sbjct: 194 PLGLEADMWSIGVITYILLSG--------------------ASP------FLGDTKQETL 227 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + + F LA D I K+L + R+R+T+ +AL HP++ Sbjct: 228 ANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4UZD-A nrPDB Length = 287 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 47/289 (16%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIR 126 P+GKG +G V A ++ +A+K + A K + LR E+++ H+ H NI+ Sbjct: 15 PLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR-- 72 Query: 127 DIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALS---EEHCQYFLYQILRGLKYIHS 182 L F+D Y +++ L + R Q LS E+ ++ ++ L Y HS Sbjct: 73 ------LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+KP NLLL + +LKI DFG + V + S T T Y PE++ + Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGRMHD 184 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+WS+G + E + KP F E E KR R Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPF----------------------EANTYQETYKRISR-- 220 Query: 303 PPYPRQSITDKFPT-VHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + FP V A DLI ++L +P +R + + L HP++ + Sbjct: 221 -------VEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 262 >2GCD-A nrPDB Length = 309 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 107/198 (54%), Gaps = 12/198 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 IG G++G V A + +E VAIKK++ + + + ++E++ L+ + H N + R Sbjct: 23 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 82 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 LR + + Y L +DL ++ + L E + L+GL Y+HS N++ Sbjct: 83 CY---LREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTHGALQGLAYLHSHNMI 137 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--NSSDYTAA 244 HRD+K N+LL+ +K+ DFG A + + ++ +V T ++ APE++L + Y Sbjct: 138 HRDVKAGNILLSEPGLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQYDGK 194 Query: 245 IDVWSVGCIFMELMDRKP 262 +DVWS+G +EL +RKP Sbjct: 195 VDVWSLGITCIELAERKP 212 >2XNP-A nrPDB Length = 279 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 106/211 (50%), Gaps = 17/211 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAI-KKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 + IG G+YG C + +++ + + K++ + + + + E+ LLR + H NIV Sbjct: 11 LYTIGTGSYG-RCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVR 69 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQII----RSNQALSEEHCQYFLYQILRGLKY 179 D I + +YI E + DL +I + Q L EE + Q+ LK Sbjct: 70 YYDRI---IDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126 Query: 180 IHSAN-----VLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPE 233 H + VLHRDLKP+N+ L+ ++K+ DFGLAR+ + ++ F +V T +Y +PE Sbjct: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 +N Y D+WS+GC+ EL P F Sbjct: 187 -QMNRMSYNEKSDIWSLGCLLYELCALMPPF 216 >4TNB-A nrPDB Length = 590 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 96/200 (48%), Gaps = 4/200 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHMDHENIVAIRD 127 +GKG +G VC+ T + A K++ K + L E ++L ++ + +V + Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL-- 249 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++A V D H N EE ++ +IL GL+ +H N ++ Sbjct: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVY 309 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLKP N+LL+ ++I D GLA E D + V T Y APE +LN+ Y + D Sbjct: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE-VLNNQRYGLSPDY 368 Query: 248 WSVGCIFMELMDRKPLFPGR 267 W +GC+ E+++ + F GR Sbjct: 369 WGLGCLIYEMIEGQSPFRGR 388 >3TAC-A nrPDB Length = 361 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 134/293 (45%), Gaps = 45/293 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANA-FDNK--IDAKRTLREIKLLRHMDHENIVAI 125 IGKG + +V +N ET + A+K + A F + + + RE + + H +IV + Sbjct: 34 IGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVEL 93 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDL-HQIIRSNQA---LSEEHCQYFLYQILRGLKYI 180 + ++ +Y+ +E MD DL +I++ A SE +++ QIL L+Y Sbjct: 94 LETY-----SSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYC 148 Query: 181 HSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLL 236 H N++HRD+KP +LL + + +K+ FG+A ES + V T + APE ++ Sbjct: 149 HDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE-VV 207 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 Y +DVW G I L+ F G RL +I + +N Sbjct: 208 KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE----RLFEGIIKGKYK-----MN---- 254 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 PRQ + + A DL+ +ML DP RITV +AL HP+L Sbjct: 255 ---------PRQ-----WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLK 293 >5KZ7-A nrPDB Length = 346 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 128/286 (44%), Gaps = 36/286 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG + V A + T + VA+K I N ++ RE+++++ ++H NIV + ++ Sbjct: 41 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV 100 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +Y+ E ++ + ++ + E+ + QI+ ++Y H ++H Sbjct: 101 IETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVH 155 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLK NLLL+A+ ++KI DFG + + + + + + Y APEL +DV Sbjct: 156 RDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 215 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 WS+G I L+ F G++ L E +R +R P Sbjct: 216 WSLGVILYTLVSGSLPFDGQN----------------------LKELRERVLRGKYRIPF 253 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 TD +L++K L +P +R T+ + ++N H+ Sbjct: 254 YMSTD--------CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHE 291 >2YZA-A nrPDB Length = 276 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 73/286 (25%), Positives = 122/286 (42%), Gaps = 41/286 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +I P D ++ E + +L I + + E + QIL + Y H V+ Sbjct: 79 VISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 133 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + + Y APE++ +D Sbjct: 134 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVD 193 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--SEEELEFLNENAKRYIRQLPP 304 +WS G I L L GT +E + L + + + +P Sbjct: 194 IWSCGVILYAL---------------------LCGTLPFDDEHVPTLFKKIRGGVFYIPE 232 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 Y +S+ L+ ML DP +R T+ D H + Sbjct: 233 YLNRSVA-----------TLLMHMLQVDPLKRATIKDIREHEWFKQ 267 >6C9D-A nrPDB Length = 459 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 104/207 (50%), Gaps = 7/207 (3%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG + V A + T VA+K I N ++ RE+++++ ++H NIV + ++ Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 88 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +Y+ E ++ + ++ + E+ + QI+ ++Y H ++H Sbjct: 89 IETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 143 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLK NLLL+ + ++KI DFG + + + + E+ + Y APEL +DV Sbjct: 144 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEVDV 203 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLR 274 WS+G I L+ F G++ + +LR Sbjct: 204 WSLGVILYTLVSGSLPFDGQN-LKELR 229 >4JXF-A nrPDB Length = 266 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 137/290 (47%), Gaps = 50/290 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +GKG++ V A + T VAIK I A +R E+K+ + H +I+ Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL---- 70 Query: 128 IIPPPLRNAFND---VYIAYELM-DTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHS 182 L N F D VY+ E+ + ++++ +++ + SE ++F++QI+ G+ Y+HS Sbjct: 71 ----ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 126 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSS 239 +LHRDL SNLLL N ++KI DFGLA ++ E + T Y +PE+ S+ Sbjct: 127 HGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHY--TLCGTPNYISPEIATRSA 184 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 + DVWS+GC+F L+ +P F ++ + + E FL+ AK Sbjct: 185 -HGLESDVWSLGCMFYTLLIGRPPFD----TDTVKNTLNKVVLADYEMPSFLSIEAK--- 236 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 DLI ++L +P R+++ L HP+++ Sbjct: 237 -----------------------DLIHQLLRRNPADRLSLSSVLDHPFMS 263 >1ZXE-A nrPDB Length = 303 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 121/237 (51%), Gaps = 32/237 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I +G+GA+G V A N+ + AIKKI + + K+ L E+ LL ++H+ +V Sbjct: 11 IAVLGQGAFGQVVKARNALDSRYYAIKKIRHT-EEKLST--ILSEVMLLASLNHQYVVRY 67 Query: 126 -------RDIIPP-PLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYF--LYQIL 174 R+ + P + ++I E + L+ +I S + L+++ +Y+ QIL Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHS-ENLNQQRDEYWRLFRQIL 126 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR---------------VTSESDF 219 L YIHS ++HR+LKP N+ ++ + ++KI DFGLA+ + SD Sbjct: 127 EALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDN 186 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 +T + T Y A E+L + Y ID++S+G IF E++ P G + V+ L+ L Sbjct: 187 LTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILKKL 241 >2YAB-A nrPDB Length = 361 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 123/290 (42%), Gaps = 41/290 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G + IV T A K I + A + + RE+ +LR + H NI+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + D+ DV + EL+ +L + ++LSEE F+ QIL G+ Y+H+ Sbjct: 80 LHDVYENR-----TDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 184 NVLHRDLKPSN-LLLNANC---DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 + H DLKP N +LL+ N +K+ DFGLA + T + APE ++N Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYE 193 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 D+WS+G I L+ F G D + + + +EE Sbjct: 194 PLGLEADMWSIGVITYILLSGASPFLG-DTKQETLANITAVSYDFDEEF----------- 241 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 F LA D I K+L + R+R+T+ +AL HP++ Sbjct: 242 --------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4APC-A nrPDB Length = 350 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 106/216 (49%), Gaps = 17/216 (7%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+ KY + IG+G++G ++E IK+I + + + + + RE+ +L Sbjct: 20 FQSMEKY-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLA 78 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQAL--SEEHCQYF 169 +M H NIV R+ +F + Y +MD DL + I + + + E+ + Sbjct: 79 NMKHPNIVQYRE--------SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW 130 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRW 228 QI LK++H +LHRD+K N+ L + +++ DFG+ARV S + + T + Sbjct: 131 FVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPY 190 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 Y +PE+ N Y D+W++GC+ EL K F Sbjct: 191 YLSPEICENKP-YNNKSDIWALGCVLYELCTLKHAF 225 >6CQF-A nrPDB Length = 297 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 75/270 (27%), Positives = 127/270 (47%), Gaps = 20/270 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G YG V A + + + VA+K + D+ D +EI +L+ H NIVA Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKMVKMEPDD--DVSTLQKEILILKTCRHANIVAYHGS 81 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++I E L I + +LSE Y ++L+GL Y+HS +H Sbjct: 82 YL-----WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIH 136 Query: 188 RDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPEL--LLNSSDYTAA 244 RD+K +N+L+N ++++ DFG+ A++ + ++ T ++ APE+ + Y Sbjct: 137 RDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGYNEL 196 Query: 245 IDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 D+WS+G +EL + + PLF VH LR+L + T S + L E K + Sbjct: 197 CDIWSLGITAIELAELQPPLF----DVHPLRVLFLM--TKSGYQPPRLKEKGK-WSAAFH 249 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 + + ++T K P P A ++ L P Sbjct: 250 NFIKVTLT-KSPKKRPSATKMLSHQLVSQP 278 >3ORZ-A nrPDB Length = 316 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 49/295 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAF---DNKIDAKRTLREIKLLRHMDHENIVAI 125 +G+G++ V A T+ AIK + +NK+ RE ++ +DH V + Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKV--PYVTRERDVMSRLDHPFFVKL 102 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + F Y + +L + IR + E +++ +I+ L+Y+H + Sbjct: 103 YFCFQDDEKLYFGLSYAK----NGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARV---TSESDFMTEYVVTRWYRAPELLLNSSDYT 242 +HRDLKP N+LLN + ++I DFG A+V S+ +V T Y +PELL S Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACK 218 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 ++ D+W++GCI +L+ P F + + +++L E +F Sbjct: 219 SS-DLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL-------EYDF------------ 258 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA------LAHPYLNSL 351 +KF P A DL+EK+L D +R+ + AHP+ S+ Sbjct: 259 --------PEKF---FPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >2HAK-A nrPDB Length = 328 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 99/201 (49%), Gaps = 6/201 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG + V A + T VA+K I N ++ RE+++++ ++H NIV + ++ Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV 82 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 I +Y+ E ++ + ++ + E+ + QI+ ++Y H ++H Sbjct: 83 IETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 137 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLK NLLL+ + ++KI DFG + + + + + + Y APEL +DV Sbjct: 138 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 197 Query: 248 WSVGCIFMELMDRKPLFPGRD 268 WS+G I L+ F G++ Sbjct: 198 WSLGVILYTLVSGSLPFDGQN 218 >3UC3-A nrPDB Length = 361 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 121/284 (42%), Gaps = 37/284 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG G +G+ + T E VA+K I A D + REI R + H NIV + Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQ-----REIINHRSLRHPNIVRFK 82 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 ++I P A Y + +L++ I + SE+ ++F Q+L G+ Y HS + Sbjct: 83 EVILTPTHLAIIMEYAS----GGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQIC 138 Query: 187 HRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 HRDLK N LL+ + LKICDFG ++ + V T Y APE+LL Sbjct: 139 HRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKI 198 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 DVWS G + L + L+G E+ E + K R L Sbjct: 199 ADVWSCG---------------------VTLYVMLVGAYPFEDPEEPRDYRKTIQRILS- 236 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + SI D + P LI ++ DP RI++ + H + Sbjct: 237 -VKYSIPDDI-RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >3KA0-A nrPDB Length = 320 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 85/304 (27%), Positives = 130/304 (42%), Gaps = 38/304 (12%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHE 120 YK +G G G V N T E A+K + D + RE++L R Sbjct: 17 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCP 69 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGL 177 +IV I D+ L + I E +D +L I R +QA +E + I + Sbjct: 70 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 128 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +TE T +Y APE Sbjct: 129 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPE- 187 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 +L Y + D+WS+G I L+ P F H L + + + EF N Sbjct: 188 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN-- 242 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 P + S K LI +L +P +R+T+ + + HP++ + Sbjct: 243 --------PEWSEVSEEVKM---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 285 Query: 355 SDEP 358 P Sbjct: 286 PQTP 289 >2JAM-A nrPDB Length = 304 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 134/309 (43%), Gaps = 49/309 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN--AF-DNKIDAKRTLREIKLLRHMDHENIVAI 125 +G GA+ V T + A+K I AF D+ ++ EI +L+ + HENIV + Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE-----NEIAVLKKIKHENIVTL 71 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 DI + Y+ +L+ +L I +E+ + Q+L +KY+H Sbjct: 72 EDIY-----ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 185 VLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDLKP NLL N + I DFGL+++ ++ M+ T Y APE+L Y Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKP-Y 184 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 + A+D WS+G I L+ P F E E + + + Y Sbjct: 185 SKAVDCWSIGVITYILLCGYPPF------------------YEETESKLFEKIKEGYYEF 226 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN---SLH-DISDE 357 P+ + + A D I +L DP R T AL+HP+++ +LH DI Sbjct: 227 ESPF--------WDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPS 278 Query: 358 PECTIPFNF 366 I NF Sbjct: 279 VSLQIQKNF 287 >4OW8-A nrPDB Length = 283 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 97/202 (48%), Gaps = 5/202 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAIRD 127 I G G V A+++ VA+K + + F + + +R E + ++H I ++ D Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 78 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + Y+ EL++ + L+ +++ LS H L Q R L+ H+A ++ Sbjct: 79 YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLV 138 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPELLLNSSDYTAA 244 HRD+KP N+L+ +KI DFG+A+ + +V T Y APE L D + A Sbjct: 139 HRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG-HDASPA 197 Query: 245 IDVWSVGCIFMELMDRKPLFPG 266 DV+S+G + E + K F G Sbjct: 198 SDVYSLGVVGYEAVSGKRPFAG 219 >4X3F-A nrPDB Length = 337 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 97/202 (48%), Gaps = 5/202 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAIRD 127 I G G V A+++ VA+K + + F + + +R E + ++H I ++ D Sbjct: 20 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 79 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + Y+ EL++ + L+ +++ LS H L Q R L+ H+A ++ Sbjct: 80 YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLV 139 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPELLLNSSDYTAA 244 HRD+KP N+L+ +KI DFG+A+ + +V T Y APE L D + A Sbjct: 140 HRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG-HDASPA 198 Query: 245 IDVWSVGCIFMELMDRKPLFPG 266 DV+S+G + E + K F G Sbjct: 199 SDVYSLGVVGYEAVSGKRPFAG 220 >6B2Q-A nrPDB Length = 317 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 97/202 (48%), Gaps = 5/202 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAIRD 127 I G G V A+++ VA+K + + F + + +R E + ++H I ++ D Sbjct: 40 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 99 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + Y+ EL++ + L+ +++ LS H L Q R L+ H+A ++ Sbjct: 100 YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLV 159 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPELLLNSSDYTAA 244 HRD+KP N+L+ +KI DFG+A+ + +V T Y APE L D + A Sbjct: 160 HRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG-HDASPA 218 Query: 245 IDVWSVGCIFMELMDRKPLFPG 266 DV+S+G + E + K F G Sbjct: 219 SDVYSLGVVGYEAVSGKRPFAG 240 >3ZUT-A nrPDB Length = 362 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/192 (32%), Positives = 92/192 (47%), Gaps = 9/192 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G +G+ + ++NE VA+K I KID + REI R + H NIV +++ Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIERG--EKID-ENVKREIINHRSLRHPNIVRFKEV 83 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 I P A Y + +L + I + SE+ ++F Q++ G+ Y H+ V HR Sbjct: 84 ILTPTHLAIVMEYAS----GGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 Query: 189 DLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 DLK N LL+ + LKIC FG ++ + V T Y APE+LL D Sbjct: 140 DLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVAD 199 Query: 247 VWSVGCIFMELM 258 VWS G ++ Sbjct: 200 VWSCGVTLYVML 211 >6FD3-A nrPDB Length = 300 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/281 (24%), Positives = 129/281 (45%), Gaps = 36/281 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA G V +A++ T + VAIK++ + + + EI ++R + NIV D Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDS 87 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 +++++ E + + + + E + L+ L ++HS V+HR Sbjct: 88 YL-----VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHR 142 Query: 189 DLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+K N+LL + +K+ DFG A++T E + V T ++ APE++ + Y +D+ Sbjct: 143 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDI 201 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 WS+G + +E+++ +P + + + L L+ GTP + E L+ + Sbjct: 202 WSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSAVFR----------- 249 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 D + + L D RR + + L HP+L Sbjct: 250 ---------------DFLNRCLEMDVDRRGSAKELLQHPFL 275 >3Q53-A nrPDB Length = 306 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 111/216 (51%), Gaps = 10/216 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA G V +AM+ T + VAI+++ + + + EI ++R + NIV D Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVMRENKNPNIVNYLDS 86 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 +++++ E + + + + E + L+ L+++HS V+HR Sbjct: 87 YL-----VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHR 141 Query: 189 DLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+K N+LL + +K+ DFG A++T E + V T ++ APE++ + Y +D+ Sbjct: 142 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVDI 200 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 WS+G + +E+++ +P + + + L L+ GTP Sbjct: 201 WSLGIMAIEMIEGEPPYLNENPLRALYLIAT-NGTP 235 >5D9K-A nrPDB Length = 330 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 118/243 (48%), Gaps = 23/243 (9%) Query: 69 IGKGAYG---IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G+G++G +V S+ + A+K + A D RT E +L ++H IV Sbjct: 38 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVK- 96 Query: 126 RDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 L AF Y ++D DL + +EE +++L ++ L ++H Sbjct: 97 -------LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 149 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSD 240 S +++RDLKP N+LL+ +K+ DFGL++ + + + + T Y APE ++N Sbjct: 150 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE-VVNRRG 208 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL-IGTPSEEELEFLNENAKRYI 299 +T + D WS G + E++ F G+D + ++++ +G P +FL+ A+ + Sbjct: 209 HTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP-----QFLSPEAQSLL 263 Query: 300 RQL 302 R L Sbjct: 264 RML 266 >2JDO-A nrPDB Length = 342 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 123/271 (45%), Gaps = 37/271 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +GKG +G V T A+K + K + T+ E ++L++ H + A++ Sbjct: 18 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 77 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 R F Y +L + + +EE +++ +I+ L+Y+HS +V++ Sbjct: 78 AFQTHDRLCFVMEYAN----GGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVY 133 Query: 188 RDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RD+K NL+L+ + +KI DFGL + S+ M + T Y APE +L +DY A+D Sbjct: 134 RDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE-VLEDNDYGRAVD 192 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 W +G + E+M + F +DH L++ EE+ F P Sbjct: 193 WWGLGVVMYEMMCGRLPFYNQDHERLFELIL-------MEEIRF---------------P 230 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 R T+ P A L+ +L DP++R+ Sbjct: 231 R--------TLSPEAKSLLAGLLKKDPKQRL 253 >3UDB-A nrPDB Length = 317 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 62/192 (32%), Positives = 91/192 (47%), Gaps = 9/192 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G +G+ + + NE VA+K I KID + REI R + H NIV +++ Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIERG--EKID-ENVKREIINHRSLRHPNIVRFKEV 83 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 I P A Y + +L + I + SE+ ++F Q++ G+ Y H+ V HR Sbjct: 84 ILTPTHLAIVMEYAS----GGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVAHR 139 Query: 189 DLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 DLK N LL+ + LKI DFG ++ + V T Y APE+LL D Sbjct: 140 DLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDGKVAD 199 Query: 247 VWSVGCIFMELM 258 VWS G ++ Sbjct: 200 VWSCGVTLYVML 211 >2OZA-A nrPDB Length = 356 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 129/304 (42%), Gaps = 38/304 (12%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHE 120 YK +G G G V N T E A+K + D + RE++L R Sbjct: 19 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCP 71 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGL 177 +IV I D+ L + I E +D +L I R +QA +E + I + Sbjct: 72 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +T T +Y APE Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE- 189 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 +L Y + D+WS+G I L+ P F H L + + + EF N Sbjct: 190 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN-- 244 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 P + S K LI +L +P +R+T+ + + HP++ + Sbjct: 245 --------PEWSEVSEEVKM---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 287 Query: 355 SDEP 358 P Sbjct: 288 PQTP 291 >1NY3-A nrPDB Length = 400 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 129/304 (42%), Gaps = 38/304 (12%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHE 120 YK +G G G V N T E A+K + D + RE++L R Sbjct: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCP 115 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGL 177 +IV I D+ L + I E +D +L I R +QA +E + I + Sbjct: 116 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +T T +Y APE Sbjct: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE- 233 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 +L Y + D+WS+G I L+ P F H L + + + EF N Sbjct: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN-- 288 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 P + S K LI +L +P +R+T+ + + HP++ + Sbjct: 289 --------PEWSEVSEEVKM---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 Query: 355 SDEP 358 P Sbjct: 332 PQTP 335 >2UV2-A nrPDB Length = 325 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 104/210 (49%), Gaps = 26/210 (12%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I +G GA+G V A N ET+ A K I + +++ + EI +L DH NIV + Sbjct: 42 IGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELE--DYMVEIDILASCDHPNIVKL 99 Query: 126 RDIIPPPLRNAF---NDVYIAYEL-----MDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 D AF N+++I E +D + ++ R L+E Q Q L L Sbjct: 100 LD--------AFYYENNLWILIEFCAGGAVDAVMLELER---PLTESQIQVVCKQTLDAL 148 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLL 236 Y+H ++HRDLK N+L + D+K+ DFG+ A+ T ++ T ++ APE+++ Sbjct: 149 NYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM 208 Query: 237 --NSSD--YTAAIDVWSVGCIFMELMDRKP 262 S D Y DVWS+G +E+ + +P Sbjct: 209 CETSKDRPYDYKADVWSLGITLIEMAEIEP 238 >2XIK-A nrPDB Length = 294 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 80/282 (28%), Positives = 134/282 (47%), Gaps = 37/282 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V +++ T E VAIK I + + + + + +EI +L D I Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIK-IIDLEEAEDEIEDIQQEITVLSQCDSPYITRY--- 82 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 L++ ++I E + + L E + L +IL+GL Y+HS +HR Sbjct: 83 FGSYLKS--TKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHR 140 Query: 189 DLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+K +N+LL+ D+K+ DFG+A ++T +V T ++ APE++ S+ Y D+ Sbjct: 141 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDFKADI 199 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 WS+G +EL +P P D +H +R+L LI S LE +++K P+ Sbjct: 200 WSLGITAIELAKGEP--PNSD-LHPMRVLF-LIPKNSPPTLE--GQHSK-------PFK- 245 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + +E L DPR R T + L H ++ Sbjct: 246 ---------------EFVEACLNKDPRFRPTAKELLKHKFIT 272 >2X4F-A nrPDB Length = 373 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 38/285 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V + T +A K I D + EI ++ +DH N++ + D Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTR--GMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 ND+ + E +D +II + L+E F+ QI G++++H +L Sbjct: 155 FESK-----NDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYIL 209 Query: 187 HRDLKPSNLL-LNANC-DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H DLKP N+L +N + +KI DFGLAR + + T + APE ++N + Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPE-VVNYDFVSFP 268 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 D+WSVG I L+ F G + L ++ +EE + ++E AK + Sbjct: 269 TDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEF------ 322 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 I K+L + RI+ +AL HP+L+ Sbjct: 323 --------------------ISKLLIKEKSWRISASEALKHPWLS 347 >1S9I-A nrPDB Length = 354 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 106/210 (50%), Gaps = 25/210 (11%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIK----KIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G G G+V + + +A K +I A N+I +RE+++L + Sbjct: 21 ISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQI-----IRELQVLHECNSPY 75 Query: 122 IVAIRDIIPPPLRNAF---NDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 177 IV AF ++ I E MD L Q+++ + + EE +LRGL Sbjct: 76 IVG--------FYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGL 127 Query: 178 KYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y APE L Sbjct: 128 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMAPE-RL 185 Query: 237 NSSDYTAAIDVWSVGCIFMEL-MDRKPLFP 265 + Y+ D+WS+G +EL + R P+ P Sbjct: 186 QGTHYSVQSDIWSMGLSLVELAVGRYPIPP 215 >4FR4-A nrPDB Length = 384 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 103/202 (50%), Gaps = 16/202 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 IGKG++G VC ++T + A+K + + + + +E+++++ ++H +V Sbjct: 23 IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVN--- 79 Query: 128 IIPPPLRNAFND----VYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 L +F D + L+ DL ++ N EE + F+ +++ L Y+ + Sbjct: 80 -----LWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 134 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN--SSDY 241 ++HRD+KP N+LL+ + + I DF +A + +T T+ Y APE+ + + Y Sbjct: 135 RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGY 194 Query: 242 TAAIDVWSVGCIFMELM-DRKP 262 + A+D WS+G EL+ R+P Sbjct: 195 SFAVDWWSLGVTAYELLRGRRP 216 >4B8L-A nrPDB Length = 286 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/288 (24%), Positives = 129/288 (44%), Gaps = 45/288 (15%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIR 126 P+GKG +G V A + +A+K + + K + LR EI++ H+ H NI+ Sbjct: 22 PLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILR-- 79 Query: 127 DIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + N F+D Y +++ +L++ ++ + E+ F+ ++ L Y H Sbjct: 80 ------MYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHE 133 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+KP NLL+ +LKI DFG + V + S T Y PE++ + Sbjct: 134 RKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMI-EGKTHD 191 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+W G + E + P F H R ++ + +L+F Sbjct: 192 EKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV-------DLKF------------ 232 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 PP+ ++D + DLI K+L + P +R+ + + HP++ + Sbjct: 233 PPF----LSDG-------SKDLISKLLRYHPPQRLPLKGVMEHPWVKA 269 >2Z7Q-A nrPDB Length = 321 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 117/243 (48%), Gaps = 23/243 (9%) Query: 69 IGKGAYG---IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G+G++G +V ++ A+K + A D RT E +L ++H +V Sbjct: 36 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVK- 94 Query: 126 RDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 L AF Y ++D DL + +EE +++L ++ GL ++H Sbjct: 95 -------LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 147 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSD 240 S +++RDLKP N+LL+ +K+ DFGL++ + + + T Y APE ++N Sbjct: 148 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE-VVNRQG 206 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL-IGTPSEEELEFLNENAKRYI 299 ++ + D WS G + E++ F G+D + L+++ +G P +FL+ A+ + Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP-----QFLSTEAQSLL 261 Query: 300 RQL 302 R L Sbjct: 262 RAL 264 >4EQM-A nrPDB Length = 294 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/220 (31%), Positives = 112/220 (50%), Gaps = 17/220 (7%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRH 116 + +YK + +G G V A ++ N VAIK I K + KR RE+ Sbjct: 9 INERYKI-VDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQ 67 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT----DLHQIIRSNQALSEEHCQYFLYQ 172 + H+NIV++ D+ + +D Y Y +M+ L + I S+ LS + F Q Sbjct: 68 LSHQNIVSMIDV------DEEDDCY--YLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQ 119 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-MTEYVV-TRWYR 230 IL G+K+ H ++HRD+KP N+L+++N LKI DFG+A+ SE+ T +V+ T Y Sbjct: 120 ILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYF 179 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHV 270 +PE + D++S+G + E++ +P F G V Sbjct: 180 SPEQAKGEA-TDECTDIYSIGIVLYEMLVGEPPFNGETAV 218 >2WQN-A nrPDB Length = 310 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/232 (29%), Positives = 113/232 (48%), Gaps = 35/232 (15%) Query: 49 YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-- 106 YN N F + K IG+G + V A VA+KK+ FD +DAK Sbjct: 28 YNTLAN-FRIEKK-------IGRGQFSEVYRAACLLDGVPVALKKV-QIFD-LMDAKARA 77 Query: 107 -TLREIKLLRHMDHENIVA-----IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIR--- 156 ++EI LL+ ++H N++ I D N++ I EL D DL ++I+ Sbjct: 78 DCIKEIDLLKQLNHPNVIKYYASFIED----------NELNIVLELADAGDLSRMIKHFK 127 Query: 157 -SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VT 214 + + E + Q+ L+++HS V+HRD+KP+N+ + A +K+ D GL R + Sbjct: 128 KQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS 187 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPG 266 S++ V T +Y +PE ++ + Y D+WS+GC+ E+ + F G Sbjct: 188 SKTTAAHSLVGTPYYMSPE-RIHENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >3DLS-A nrPDB Length = 335 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 97/209 (46%), Gaps = 12/209 (5%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA-------FDNKIDAKRTLR 109 E + KY + P+G GA+G V +A++ E N+ V +K I ++ K TL Sbjct: 21 EYSQKYST-MSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL- 78 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYF 169 EI +L ++H NI+ + DI F + + DL I + L E Y Sbjct: 79 EIAILSRVEHANIIKVLDIFE---NQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYI 135 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 Q++ + Y+ +++HRD+K N+++ + +K+ DFG A + T Y Sbjct: 136 FRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEY 195 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELM 258 APE+L+ + +++WS+G L+ Sbjct: 196 CAPEVLMGNPYRGPELEMWSLGVTLYTLV 224 >3LM0-A nrPDB Length = 327 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 129/311 (41%), Gaps = 59/311 (18%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 F N + +T+K +G+G + +V ++ T + A K + + L EI Sbjct: 26 FNNFYILTSK------ELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEI 79 Query: 112 KLLR-----------HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 +L H +EN I I+ + L +L +++ N Sbjct: 80 AVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEI------FSLCLPELAEMVSENDV 133 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN---CDLKICDFGLARVTSES 217 + + QIL G+ Y+H N++H DLKP N+LL++ D+KI DFG++R + Sbjct: 134 IR------LIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHA 187 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 + E + T Y APE +LN T A D+W++G I L+ F G D+ + L + Sbjct: 188 CELREIMGTPEYLAPE-ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN-QETYLNI 245 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 + EE F +V LA D I+ +L +P +R Sbjct: 246 SQVNVDYSEE-------------------------TFSSVSQLATDFIQSLLVKNPEKRP 280 Query: 338 TVLDALAHPYL 348 T L+H +L Sbjct: 281 TAEICLSHSWL 291 >4GS6-A nrPDB Length = 315 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 102/204 (50%), Gaps = 24/204 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+GA+G+VC A + VAIK+I +++ + K + E++ L ++H NIV + Sbjct: 17 VGRGAFGVVCKA--KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYGA 70 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQAL---SEEHCQYFLYQILRGLKYIHSAN 184 N V + E + L+ ++ + L + H + Q +G+ Y+HS Sbjct: 71 -------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQ 123 Query: 185 ---VLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 ++HRDLKP NLLL A LKICDFG A MT + + APE + S+ Sbjct: 124 PKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPE-VFEGSN 180 Query: 241 YTAAIDVWSVGCIFMELMDRKPLF 264 Y+ DV+S G I E++ R+ F Sbjct: 181 YSEKCDVFSWGIILWEVITRRKPF 204 >5KCV-A nrPDB Length = 460 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 87/339 (25%), Positives = 146/339 (43%), Gaps = 57/339 (16%) Query: 2 DGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAK 61 DG Q AA+ + F + +PS G E + +L+ ++ + N FE Sbjct: 122 DGLKKQAAAEMD-------FRSGSPSDN-SGAEEMEVSLAKP----KHRVTMNEFEY--- 166 Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHE 120 + +GKG +G V T A+K + K + TL E ++L++ H Sbjct: 167 ----LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 222 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 + A++ R F Y +L + + SE+ +++ +I+ L Y+ Sbjct: 223 FLTALKYSFQTHDRLCFVMEYAN----GGELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 181 HS-ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNS 238 HS NV++RDLK NL+L+ + +KI DFGL + + M + T Y APE +L Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE-VLED 337 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 +DY A+D W +G + E+M + F +DH L++ EE+ F Sbjct: 338 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------MEEIRF-------- 382 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 PR T+ P A L+ +L DP++R+ Sbjct: 383 -------PR--------TLGPEAKSLLSGLLKKDPKQRL 406 >4YNZ-A nrPDB Length = 342 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 90/190 (47%), Gaps = 4/190 (2%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG G+V ++ T + VAIK + ++ + REI +L+ ++H +++ + D+ Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDV 77 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 N + + +L + L+ + + F QI+ L + HS ++ HR Sbjct: 78 Y----ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHR 133 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVW 248 DLKP NLLL+ +++I DFG+A + + + Y PE++ DVW Sbjct: 134 DLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVW 193 Query: 249 SVGCIFMELM 258 S G I L+ Sbjct: 194 SCGVILFALL 203 >3MV5-A nrPDB Length = 342 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 73/272 (26%), Positives = 121/272 (44%), Gaps = 38/272 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +GKG +G V T A+K + K + TL E ++L++ H + A++ Sbjct: 18 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 77 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS-ANVL 186 R F Y +L + + SE+ +++ +I+ L Y+HS NV+ Sbjct: 78 SFQTHDRLCFVMEYAN----GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 133 Query: 187 HRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 +RDLK NL+L+ + +KI DFGL + + M + T Y APE +L +DY A+ Sbjct: 134 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE-VLEDNDYGRAV 192 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D W +G + E+M + F +DH L++ EE+ F Sbjct: 193 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------MEEIRF--------------- 230 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 PR T+ P A L+ +L DP++R+ Sbjct: 231 PR--------TLGPEAKSLLSGLLKKDPKQRL 254 >6BDL-A nrPDB Length = 347 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 110/245 (44%), Gaps = 21/245 (8%) Query: 66 IMPIGKGAYGIV-CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 I +G G +G V + SE +++ A+K + + +R K + H + + Sbjct: 39 IDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIV 98 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT----DLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 L F D Y LM+ +L I+R + + +++ ++ Y+ Sbjct: 99 -------RLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 HS +++RDLKP NL+L+ K+ DFG A+ + T Y APE++LN Sbjct: 152 HSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGH 211 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF---LNENAKR 297 +A D WS+G + EL+ P F G D + +++ I + +EF + +NA Sbjct: 212 DISA-DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI-----DMIEFPKKIAKNAAN 265 Query: 298 YIRQL 302 I++L Sbjct: 266 LIKKL 270 >3UTO-A nrPDB Length = 573 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 66/284 (23%), Positives = 117/284 (41%), Gaps = 38/284 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA+G+V T + A K + ++ D + +EI+ + + H +V + D Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKETVRKEIQTMSVLRHPTLVNLHDA 222 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 N++ + YE M ++ + +SE+ ++ Q+ +GL ++H N + Sbjct: 223 FEDD-----NEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYV 277 Query: 187 HRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H DLKP N++ + +LK+ DFGL + T + APE + Sbjct: 278 HLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKPVGYY 336 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 D+WSVG + L+ F G + LR + + ++E+ K +IR Sbjct: 337 TDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR---- 392 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 K+L DP R+T+ AL HP+L Sbjct: 393 ----------------------KLLLADPNTRMTIHQALEHPWL 414 >5H2U-A nrPDB Length = 267 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 106/203 (52%), Gaps = 14/203 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V + + + VAIK I+ DN + + EI+ ++ + H++I+A+ + Sbjct: 14 LGSGYFGEVFEGLWKDRVQ-VAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILALYAV 70 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANV 185 + + + VYI ELM L +++R + + L +Q+ G+ Y+ S N Sbjct: 71 V-----SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 125 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSDYTAA 244 +HRDL N+L+ N K+ DFGLAR+ E +++ ++ + + APE L+ Y+ Sbjct: 126 IHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE-ALSRGHYSTK 184 Query: 245 IDVWSVGCIFMELMDRKPL-FPG 266 DVWS G + E+ R + +PG Sbjct: 185 SDVWSFGILLHEMFSRGQVPYPG 207 >5D7A-A nrPDB Length = 308 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 100/207 (48%), Gaps = 19/207 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV----A 124 +G G YG V + +T + AIK + D + + K+ + +K H H NI A Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH--HRNIATYYGA 82 Query: 125 IRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 PP + + +++ E TDL + + N L EE Y +ILRGL ++ Sbjct: 83 FIKKNPPGMDD---QLWLVMEFCGAGSVTDLIKNTKGN-TLKEEWIAYICREILRGLSHL 138 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSS 239 H V+HRD+K N+LL N ++K+ DFG+ A++ ++ T ++ APE++ Sbjct: 139 HQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 198 Query: 240 D----YTAAIDVWSVGCIFMELMDRKP 262 + Y D+WS+G +E+ + P Sbjct: 199 NPDATYDFKSDLWSLGITAIEMAEGAP 225 >1KOA-A nrPDB Length = 491 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 66/284 (23%), Positives = 117/284 (41%), Gaps = 38/284 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA+G+V T + A K + ++ D + +EI+ + + H +V + D Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKETVRKEIQTMSVLRHPTLVNLHDA 116 Query: 129 IPPPLRNAFNDVYIAYELMDTD--LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 N++ + YE M ++ + +SE+ ++ Q+ +GL ++H N + Sbjct: 117 FEDD-----NEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYV 171 Query: 187 HRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H DLKP N++ + +LK+ DFGL + T + APE + Sbjct: 172 HLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKPVGYY 230 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 D+WSVG + L+ F G + LR + + ++E+ K +IR Sbjct: 231 TDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR---- 286 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 K+L DP R+T+ AL HP+L Sbjct: 287 ----------------------KLLLADPNTRMTIHQALEHPWL 308 >4M7I-A nrPDB Length = 299 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 60/239 (25%), Positives = 113/239 (47%), Gaps = 31/239 (12%) Query: 65 PIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 PI +G+G +G+V A N + + AIK+I + ++ ++ +RE+K L ++H IV Sbjct: 9 PIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGIVR 67 Query: 125 -----IRDIIPPPLRNAFNDVYIAYELM---DTDLHQIIRSNQALSEEH---CQYFLYQI 173 + L+ + VY+ ++ +L + + E C + QI Sbjct: 68 YFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQI 127 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-------------FM 220 ++++HS ++HRDLKPSN+ + +K+ DFGL + + Sbjct: 128 AEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARH 187 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 T V T+ Y +PE + +S Y+ +D++S+G I EL L+P + ++R L ++ Sbjct: 188 TGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFEL-----LYPFSTQMERVRTLTDV 240 >3HKO-A nrPDB Length = 345 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 89/360 (24%), Positives = 145/360 (40%), Gaps = 80/360 (22%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI- 102 GR Y G++ E+ KY IG+G+YG+V A+ ++T AI+ I NKI Sbjct: 10 GRENLYFQGGSLLELQKKYHLK-GAIGQGSYGVVRVAIENQTR---AIRAIKIMNKNKIR 65 Query: 103 -----DAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-----------------NAFNDV 140 D +R E++L++ + H NI + ++ N F D Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDD 125 Query: 141 YIAYELMDTDLHQII----RSNQALS---------------EEHCQYFLYQILRGLKYIH 181 MD QI + +A++ E+ + QI L Y+H Sbjct: 126 STGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLH 185 Query: 182 SANVLHRDLKPSNLLLNAN--CDLKICDFGLARV-----TSESDFMTEYVVTRWYRAPEL 234 + + HRD+KP N L + N ++K+ DFGL++ E MT T ++ APE+ Sbjct: 186 NQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEV 245 Query: 235 LLNSSD-YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L +++ Y D WS G + L+ FPG + + I ++L F N Sbjct: 246 LNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDA-------DTISQVLNKKLCFENP 298 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 N + + PLA DL+ +L + R + AL HP+++ D Sbjct: 299 N-------------------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >3ALO-A nrPDB Length = 327 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 77/317 (24%), Positives = 139/317 (43%), Gaps = 40/317 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-L 114 ++ TA+ + IG+GAYG V ++ + + +A+K+I + D K + K+ L ++ + + Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEK-EQKQLLMDLDVVM 75 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-----NQALSEEHCQYF 169 R D IV + R D +I ELM T + + + + EE Sbjct: 76 RSSDCPYIVQFYGAL---FREG--DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI 130 Query: 170 LYQILRGLKYI-HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 ++ L ++ + ++HRD+KPSN+LL+ + ++K+CDFG++ +S T R Sbjct: 131 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP 190 Query: 229 YRAPELLLNSSD---YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 Y APE + S+ Y DVWS+G EL + +P + V Sbjct: 191 YMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVF-------------- 236 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 + + ++ PP S +F P I+ + LT D +R + L H Sbjct: 237 -------DQLTQVVKGDPPQLSNSEEREF---SPSFINFVNLCLTKDESKRPKYKELLKH 286 Query: 346 PYLNSLHDISDEPECTI 362 P++ + + E C + Sbjct: 287 PFILMYEERAVEVACYV 303 >5LOH-A nrPDB Length = 341 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 107/224 (47%), Gaps = 36/224 (16%) Query: 63 KPP-------IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD----NKIDAKR---TL 108 KPP + PI +GA+G V +V + K A+ + +++ A+R L Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALAL 90 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQ 167 + + H+ + L++A N+VY+ E L+ D+ ++ EE Sbjct: 91 SKSPFIVHLYYS------------LQSA-NNVYLVMEYLIGGDVKSLLHIYGYFDEEMAV 137 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-MTEYVVT 226 ++ ++ L Y+H ++HRDLKP N+L++ +K+ DFGL++VT D M + + T Sbjct: 138 KYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTT 197 Query: 227 RW------YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 R Y APELLL + + A+D W++G E + P F Sbjct: 198 RTFCGTPDYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPF 240 >1VZO-A nrPDB Length = 355 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 70/300 (23%), Positives = 136/300 (45%), Gaps = 45/300 (15%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYG---IVCSAMNSETNESVAIK--KIANAFDNKIDA 104 N+ G+ +V + + +G GAYG +V +T + A+K K A Sbjct: 43 NLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTT 102 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQA 160 + T E ++L H+ + L AF + ++D +L + + Sbjct: 103 EHTRTERQVLEHIRQSPFLV-------TLHYAFQTETKLHLILDYINGGELFTHLSQRER 155 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR--VTSESD 218 +E Q ++ +I+ L+++H +++RD+K N+LL++N + + DFGL++ V E++ Sbjct: 156 FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE 215 Query: 219 FMTEYVVTRWYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 ++ T Y AP+++ S + A+D WS+G + EL+ F Sbjct: 216 RAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF------------- 262 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 + E E ++R ++ PPYP++ + LA DLI+++L DP++R+ Sbjct: 263 -----TVDGEKNSQAEISRRILKSEPPYPQE--------MSALAKDLIQRLLMKDPKKRL 309 >4QMW-A nrPDB Length = 310 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/195 (28%), Positives = 102/195 (52%), Gaps = 8/195 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V +++ T + VAIK I + + + + + +EI +L D + Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIK-IIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGS 95 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 L++ ++I E + + L E L +IL+GL Y+HS +HR Sbjct: 96 Y---LKD--TKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHR 150 Query: 189 DLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+K +N+LL+ + ++K+ DFG+A ++T +V T ++ APE++ S+ Y + D+ Sbjct: 151 DIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDSKADI 209 Query: 248 WSVGCIFMELMDRKP 262 WS+G +EL +P Sbjct: 210 WSLGITAIELARGEP 224 >5HVK-A nrPDB Length = 315 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 100/209 (47%), Gaps = 25/209 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT-LREIKLLRHMDHENIVAIRD 127 +GKG +G + ET E + +K++ FD + +RT L+E+K++R ++H N++ Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDE--ETQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVL 186 ++ R F YI L II+S + F I G+ Y+HS N++ Sbjct: 79 VLYKDKRLNFITEYIK----GGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNII 134 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSES-------------DFMTEYVVTR--WYRA 231 HR+L N L+ N ++ + DFGLAR+ + D Y V ++ A Sbjct: 135 HRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDR 260 PE ++N Y +DV+S G + E++ R Sbjct: 195 PE-MINGRSYDEKVDVFSFGIVLCEIIGR 222 >2A1A-B nrPDB Length = 284 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 96/207 (46%), Gaps = 21/207 (10%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG G +G V A + ++ IK++ K + ++ RE+K L +DH NIV Sbjct: 16 IELIGSGGFGQVFKAKHRIDGKTYVIKRV------KYNNEKAEREVKALAKLDHVNIVHY 69 Query: 126 R------DIIPP-----PLRNAFNDVYIAYELMDTD-LHQII--RSNQALSEEHCQYFLY 171 D P R+ ++I E D L Q I R + L + Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE 129 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 QI +G+ YIHS +++RDLKPSN+ L +KI DFGL T T Y + Sbjct: 130 QITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 189 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELM 258 PE ++S DY +D++++G I EL+ Sbjct: 190 PE-QISSQDYGKEVDLYALGLILAELL 215 >6GQK-A nrPDB Length = 328 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 109/219 (49%), Gaps = 39/219 (17%) Query: 69 IGKGAYGIVCSA-----MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENI 122 +G GA+G V A + S+ +VA+K + + + + + + E+K+L ++ +HENI Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPS-AHSTEREALMSELKVLSYLGNHENI 107 Query: 123 VAI-------------------RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 V + D++ R D ++ Y++ DL++ L+ Sbjct: 108 VNLLGACTHGGPTLVITEYCCYGDLLNFLRRK--RDEFVPYKVAPEDLYK-----DFLTL 160 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE 222 EH F YQ+ +G+ ++ S N +HRDL N+LL KICDFGLAR + ++S+++ + Sbjct: 161 EHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDK 220 Query: 223 ---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + +W APE + NS YT DVWS G EL Sbjct: 221 GNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELF 257 >4FZF-B nrPDB Length = 283 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 107/210 (50%), Gaps = 11/210 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V +++ T + VAIK I + + + + + +EI +L D + Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIK-IIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG- 73 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 L+ + ++I E + + E L +IL+GL Y+HS +HR Sbjct: 74 --SYLKGS--KLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHR 129 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSESDFM-TEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+K +N+LL+ D+K+ FG+A +++ +V T ++ APE++ S+ Y + D+ Sbjct: 130 DIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA-YDSKADI 188 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 WS+G +EL +P P D +H +R+L Sbjct: 189 WSLGITAIELAKGEP--PNSD-MHPMRVLF 215 >5FET-A nrPDB Length = 847 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 103/215 (47%), Gaps = 13/215 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI--VAIR 126 IG+G +G V + T A+K ++ I + IKL R + EN IR Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSK---RSIISLNQQNNIKLEREITAENDHPFIIR 597 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + N F Y EL+ +L+ IR LS+ Q++L I+ ++Y+H N+ Sbjct: 598 LVRTFKDSNCF---YFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNI 654 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 ++RDLKP N+LL+ +K+ DFG A+ + V T Y APE++L Y + Sbjct: 655 VYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYT--LVGTPHYMAPEVILGKG-YGCTV 711 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 D+W++G E + PL G D QL + +++ Sbjct: 712 DIWALGVCLYEFI-CGPLPFGNDQEDQLEIFRDIL 745 >5F9E-A nrPDB Length = 353 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 127/297 (42%), Gaps = 57/297 (19%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN---AFDNKIDA----KRTLR---EIKLLRHMD 118 +GKG++G V A +TN+ AIK + D+ ++ KR L E L HM Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHM- 85 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 + N ++ L DL I+S ++ +I+ GL+ Sbjct: 86 -----------FCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLN 237 ++HS +++RDLK N+LL+ + +KI DFG+ + D T E+ T Y APE+LL Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG 194 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 Y ++D WS G + E++ + F G+D EEEL Sbjct: 195 QK-YNHSVDWWSFGVLLYEMLIGQSPFHGQD----------------EEEL-------FH 230 Query: 298 YIRQLPP-YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-DALAHPYLNSLH 352 IR P YPR + A DL+ K+ +P +R+ V D HP ++ Sbjct: 231 SIRMDNPFYPR--------WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 >4PWN-A nrPDB Length = 274 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 105/221 (47%), Gaps = 21/221 (9%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S+ GRF++++I IG+G++ V +++ET VA ++ + Sbjct: 5 MSNDGRFLKFDI----------------EIGRGSFKTVYKGLDTETTVEVAWCELQDRKL 48 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ 159 K + +R E ++L+ + H NIV D ++ V + + L ++ + Sbjct: 49 TKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFK 108 Query: 160 ALSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSE 216 + + + + QIL+GL+++H+ ++HRDLK N+ + +KI D GLA + Sbjct: 109 VMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKR 168 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + F + T + APE+ Y ++DV++ G +E+ Sbjct: 169 ASFAKSVIGTPEFMAPEMY--EEKYDESVDVYAFGMCMLEM 207 >4L42-A nrPDB Length = 346 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 100/213 (46%), Gaps = 25/213 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRD 127 +GKG YG V ++K+ A KI A + L++ ++R+ D + A R+ Sbjct: 26 LGKGGYGKV-----------FQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERN 74 Query: 128 IIPPPLRNAFNDVYIAYE-----------LMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 I+ D+ A++ L +L + E+ ++L +I Sbjct: 75 ILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA 134 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAPELL 235 L ++H +++RDLKP N++LN +K+ DFGL + + +T + T Y APE+L Sbjct: 135 LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEIL 194 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 + S + A+D WS+G + +++ P F G + Sbjct: 195 MRSG-HNRAVDWWSLGALMYDMLTGAPPFTGEN 226 >4P5Q-A nrPDB Length = 361 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 95/200 (47%), Gaps = 18/200 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G G +G VCS + S+ SVAIK + + K + L E ++ DH NI+ + Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK-QRRDFLGEASIMGQFDHPNIIRL 99 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R + A + L I G+KY+ Sbjct: 100 EGVVTKS-----KPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM 154 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTS---ESDFMTE--YVVTRWYRAPELLLNS 238 +HRDL N+L+N+N K+ DFGL+RV E+ + T + RW +PE + Sbjct: 155 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TSPEAIAYR 213 Query: 239 SDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 214 K-FTSASDVWSYGIVLWEVM 232 >1JPA-A nrPDB Length = 312 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 94/202 (46%), Gaps = 20/202 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VCS + + VAIK + + + K + L E ++ DH N++ + Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK-QRRDFLSEASIMGQFDHPNVIHL 99 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R N + L I G+KY+ Sbjct: 100 EGVVTKS-----TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM 154 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARV----TSESDFMTEY---VVTRWYRAPELLL 236 N +HRDL N+L+N+N K+ DFGL+R TS+ + + + RW APE + Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPE-AI 212 Query: 237 NSSDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 213 QYRKFTSASDVWSYGIVMWEVM 234 >5O0Y-A nrPDB Length = 579 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 113/263 (42%), Gaps = 49/263 (18%) Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 K RE ++ + +DH IV + D ++F V E D D + ++ ++ +SE+ Sbjct: 333 KHACREYRIHKELDHPRIVKLYDYFSLDT-DSFCTVLEYCEGNDLDFY--LKQHKLMSEK 389 Query: 165 HCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDF 219 + + QI+ LKY++ ++H DLKP N+LL A ++KI DFGL+++ + + Sbjct: 390 EARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSY 449 Query: 220 --------MTEYVVTRWYRAPELLLNSSD---YTAAIDVWSVGCIFME-LMDRKPLFPGR 267 ++ T WY PE + + + +DVWSVG IF + L RKP G Sbjct: 450 NSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF--GH 507 Query: 268 DHVHQLRLLMELIGTPSEEELEFLNENA--KRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 + Q + L EN K Q PP P V P A I Sbjct: 508 NQSQQ----------------DILQENTILKATEVQFPPK---------PVVTPEAKAFI 542 Query: 326 EKMLTFDPRRRITVLDALAHPYL 348 + L + RI V PYL Sbjct: 543 RRCLAYRKEDRIDVQQLACDPYL 565 >4RLP-A nrPDB Length = 288 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 100/213 (46%), Gaps = 25/213 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRD 127 +GKG YG V ++K+ A KI A + L++ ++R+ D + A R+ Sbjct: 13 LGKGGYGKV-----------FQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERN 61 Query: 128 IIPPPLRNAFNDVYIAYE-----------LMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 I+ D+ A++ L +L + E+ ++L +I Sbjct: 62 ILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA 121 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAPELL 235 L ++H +++RDLKP N++LN +K+ DFGL + + +T + T Y APE+L Sbjct: 122 LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEIL 181 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 + S + A+D WS+G + +++ P F G + Sbjct: 182 MRSG-HNRAVDWWSLGALMYDMLTGAPPFTGEN 213 >3FXW-A nrPDB Length = 336 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/316 (26%), Positives = 136/316 (43%), Gaps = 69/316 (21%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 + VT Y+ +G G G V + T + A+K + D+ + +E+ Sbjct: 24 YAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKARQEV---- 72 Query: 116 HMDHE-------NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEH 165 DH +IV I D+ + + + I E M+ +L I R +QA +E Sbjct: 73 --DHHWQASGGPHIVCILDVYEN-MHHGKRCLLIIMECMEGGELFSRIQERGDQAFTERE 129 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTE 222 + I ++++HS N+ HRD+KP NLL + + LK+ DFG A+ T+++ T Sbjct: 130 AAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP 189 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF---------PGRDHVHQL 273 T +Y APE+L Y + D+WS+G I L+ P F PG + Sbjct: 190 -CYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGM----KR 243 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 R+ + G P+ E E ++E+AK+ IR L L DP Sbjct: 244 RIRLGQYGFPNPEWSE-VSEDAKQLIRLL--------------------------LKTDP 276 Query: 334 RRRITVLDALAHPYLN 349 R+T+ + HP++N Sbjct: 277 TERLTITQFMNHPWIN 292 >4AF3-A nrPDB Length = 292 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 127/289 (43%), Gaps = 47/289 (16%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIR 126 P+GKG +G V A +++ VA+K + + K + LR EI++ H+ H NI+ Sbjct: 30 PLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILR-- 87 Query: 127 DIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 L N F D Y +++ +L++ ++ + E+ + ++ L Y H Sbjct: 88 ------LYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 V+HRD+KP NLLL +LKI DFG + V + S T Y PE ++ + Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPE-MIEGRMHN 199 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+W +G + EL+ P F H NE +R ++ Sbjct: 200 EKVDLWCIGVLCYELLVGNPPFESASH----------------------NETYRRIVK-- 235 Query: 303 PPYPRQSITDKFPTVHPL-AIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + KFP P A DLI K+L +P R+ + AHP++ + Sbjct: 236 -------VDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRA 277 >3PLS-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 98/204 (48%), Gaps = 20/204 (9%) Query: 69 IGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IGKG +G+V ++ AIK ++ + + + LRE L+R ++H N++A+ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVLAL 87 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSAN 184 I+ PP V + Y + DL Q IRS Q + + F Q+ RG++Y+ Sbjct: 88 IGIMLPP--EGLPHVLLPY-MCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL--------LL 236 +HRDL N +L+ + +K+ DFGLAR + EY + +R L L Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDR----EYYSVQQHRHARLPVKWTALESL 200 Query: 237 NSSDYTAAIDVWSVGCIFMELMDR 260 + +T DVWS G + EL+ R Sbjct: 201 QTYRFTTKSDVWSFGVLLWELLTR 224 >3UIU-A nrPDB Length = 306 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 97/220 (44%), Gaps = 34/220 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV-- 123 I IG G +G V A + ++ I+++ K + ++ RE+K L +DH NIV Sbjct: 17 IELIGSGGFGQVFKAKHRIDGKTYVIRRV------KYNNEKAEREVKALAKLDHVNIVHY 70 Query: 124 ------------------AIRDIIPPPLRNAFND----VYIAYELMDTD-LHQII--RSN 158 D P +N+ ++I E D L Q I R Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 130 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 + L + QI +G+ YIHS ++HRDLKPSN+ L +KI DFGL Sbjct: 131 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 190 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 T T Y +PE ++S DY +D++++G I EL+ Sbjct: 191 KRTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELL 229 >2WTK-C nrPDB Length = 305 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 128/298 (42%), Gaps = 41/298 (13%) Query: 69 IGKGAYGIVCSAMNSET--NESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G+G+YG V ++SET +V I K +EI+LLR + H+N++ + Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLY--QILRGLKYIHSAN 184 D++ +Y+ E + +++ S CQ Y Q++ GL+Y+HS Sbjct: 73 DVL---YNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQG 129 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVT---SESDFMTEYVVTRWYRAPELLLNSSDY 241 ++H+D+KP NLLL LKI G+A + D + ++ PE+ + Sbjct: 130 IVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTF 189 Query: 242 TA-AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 + +D+WS G + F G D++++ L EN + Sbjct: 190 SGFKVDIWSAGVTLYNITTGLYPFEG-DNIYK------------------LFENIGKGSY 230 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP 358 +P D P PL+ DL++ ML ++P +R ++ H + H ++ P Sbjct: 231 AIP-------GDCGP---PLS-DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAP 277 >5DYK-A nrPDB Length = 853 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 136/305 (44%), Gaps = 53/305 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI--VAIR 126 IG+G +G V + T A+K ++ ++ + IKL R + EN IR Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNN---IKLEREITAENDHPFIIR 603 Query: 127 DIIPPPLRNAFND---VYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 L F D Y EL+ +L+ IR LS+ Q++L I+ ++Y+H Sbjct: 604 ------LVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHE 657 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 N+++RDLKP N+LL+ +K+ DFG A+ + V T Y APE++L Y Sbjct: 658 RNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYT--LVGTPHYMAPEVILGKG-YG 714 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+W++G E + PL G D QL + +++ +L F Sbjct: 715 CTVDIWALGICLYEFI-CGPLPFGNDEEDQLEIFRDILTG----QLTF------------ 757 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTI 362 P Y +TD +I+L++++L P+ RI +N DI D P + Sbjct: 758 PDY----VTD------TDSINLMKRLLCRLPQGRIGC-------SINGFKDIKDHPFFS- 799 Query: 363 PFNFD 367 FN+D Sbjct: 800 NFNWD 804 >5N23-A nrPDB Length = 352 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 101/206 (49%), Gaps = 19/206 (9%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV-- 123 I +G G++G V + ET N + KI K+ + ++K + H +E + Sbjct: 47 IRTLGTGSFGRVMLVKHKET---------GNHYAMKILDKQKVVKLKQIEHTLNEKRIQQ 97 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 A+ L +F D Y +++ ++ +R SE H +++ QI+ +Y Sbjct: 98 AVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNS 238 +HS ++++RDLKP NLL++ +K+ DFG A RV + + T Y APE++L S Sbjct: 158 LHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTL--CGTPEYLAPEIIL-S 214 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLF 264 Y A+D W++G + E+ P F Sbjct: 215 KGYNKAVDWWALGVLIYEMAAGYPPF 240 >5KKR-C nrPDB Length = 395 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 105/210 (50%), Gaps = 25/210 (11%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIK----KIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G G G+V + + +A K +I A N+I +RE+++L + Sbjct: 73 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECNSPY 127 Query: 122 IVAIRDIIPPPLRNAF---NDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 177 IV AF ++ I E MD L Q+++ + E+ +++GL Sbjct: 128 IVG--------FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 179 Query: 178 KYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y +PE L Sbjct: 180 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPE-RL 237 Query: 237 NSSDYTAAIDVWSVGCIFMEL-MDRKPLFP 265 + Y+ D+WS+G +E+ + R P+ P Sbjct: 238 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 267 >6HXF-B nrPDB Length = 302 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 116/240 (48%), Gaps = 32/240 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA+G V A N ET A K I + +++ + EI++L DH IV + Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE--DYIVEIEILATCDHPYIVKL--- 81 Query: 129 IPPPLRNAFND--VYIAYELMDTDLHQII--RSNQALSEEHCQYFLYQILRGLKYIHSAN 184 L ++D ++I E I ++ L+E Q Q+L L ++HS Sbjct: 82 ----LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSS---- 239 ++HRDLK N+L+ D+++ DFG+ A+ ++ T ++ APE+++ + Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 240 --DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL-------IGTPSEEELEF 290 DY A D+WS+G +E+ + P ++ +R+L+++ + TPS+ +EF Sbjct: 198 PYDYKA--DIWSLGITLIEMAQ---IEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 252 >4WB7-A nrPDB Length = 405 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 100/204 (49%), Gaps = 16/204 (7%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVA 124 I +G G++G V + ET A+K + K+ + TL E ++L+ ++ +V Sbjct: 101 IKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 160 Query: 125 IRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 L +F D Y +M+ ++ +R SE H +++ QI+ +Y+ Sbjct: 161 --------LEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 212 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 HS ++++RDLKP NLL++ +++ DFG A+ + T Y APE++L S Sbjct: 213 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEIIL-SKG 269 Query: 241 YTAAIDVWSVGCIFMELMDRKPLF 264 Y A+D W++G + E+ P F Sbjct: 270 YNKAVDWWALGVLIYEMAAGYPPF 293 >3DKO-A nrPDB Length = 318 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 93/201 (46%), Gaps = 20/201 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VCS + + + +VAIK + + K + L E ++ DH N+V + Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK-QRRDFLCEASIMGQFDHPNVVHL 109 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R + + L I G++Y+ Sbjct: 110 EGVV-----TRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT------RWYRAPELLLN 237 +HRDL N+L+N+N K+ DFGL+RV E D Y T RW APE + Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVI-EDDPEAVYTTTGGKIPVRW-TAPE-AIQ 221 Query: 238 SSDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 222 YRKFTSASDVWSYGIVMWEVM 242 >3EQC-A nrPDB Length = 360 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 105/210 (50%), Gaps = 25/210 (11%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIK----KIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G G G+V + + +A K +I A N+I +RE+++L + Sbjct: 38 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECNSPY 92 Query: 122 IVAIRDIIPPPLRNAF---NDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 177 IV AF ++ I E MD L Q+++ + E+ +++GL Sbjct: 93 IVG--------FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 144 Query: 178 KYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y +PE L Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPE-RL 202 Query: 237 NSSDYTAAIDVWSVGCIFMEL-MDRKPLFP 265 + Y+ D+WS+G +E+ + R P+ P Sbjct: 203 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 232 >2RIO-A nrPDB Length = 434 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 140/311 (45%), Gaps = 69/311 (22%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIRD 127 +G G+ G V S VA+K++ F L EIKLL D H N++ Sbjct: 23 LGYGSSGTVV-FQGSFQGRPVAVKRMLIDF-----CDIALMEIKLLTESDDHPNVIRY-- 74 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQY--------FLYQILRGLKY 179 + F +YIA EL + +L ++ S + +S+E+ + L QI G+ + Sbjct: 75 -YCSETTDRF--LYIALELCNLNLQDLVES-KNVSDENLKLQKEYNPISLLRQIASGVAH 130 Query: 180 IHSANVLHRDLKPSNLLLNA-------------NCDLKICDFGLARV--TSESDFMTEY- 223 +HS ++HRDLKP N+L++ N + I DFGL + + +S F T Sbjct: 131 LHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 224 --VVTRWYRAPELLLNSSD------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 T +RAPELL S++ T +ID++S+GC+F ++ + G + + + Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNI 250 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 + G S +E++ L++ R I + A DLI +M+ DP + Sbjct: 251 IR---GIFSLDEMKCLHD-------------RSLIAE--------ATDLISQMIDHDPLK 286 Query: 336 RITVLDALAHP 346 R T + L HP Sbjct: 287 RPTAMKVLRHP 297 >4IDT-A nrPDB Length = 356 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/272 (26%), Positives = 128/272 (47%), Gaps = 44/272 (16%) Query: 5 SGQPAADTEM--TEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKY 62 SGQ + T + T A G + PSP+ E + L+ + + Y + T + Sbjct: 23 SGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGV--LLTEKLKPVDYEYREEVHWATHQL 80 Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G+G++G V + +T A+KK+ +++ R E + Sbjct: 81 R-----LGRGSFGEVHRMEDKQTGFQCAVKKV------RLEVFRA------------EEL 117 Query: 123 VAIRDIIPP---PLRNAFND---VYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILR 175 +A + P PL A + V I EL++ L Q+++ L E+ Y+L Q L Sbjct: 118 MACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALE 177 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTEYVVTRWY----- 229 GL+Y+HS +LH D+K N+LL+++ +CDFG A V + D + + ++T Y Sbjct: 178 GLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHA-VCLQPDGLGKDLLTGDYIPGTE 236 Query: 230 --RAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 APE++L S A +DVWS C+ + +++ Sbjct: 237 THMAPEVVLGRS-CDAKVDVWSSCCMMLHMLN 267 >3LLT-A nrPDB Length = 360 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/326 (23%), Positives = 135/326 (41%), Gaps = 49/326 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I +G G +G V + + + A+K + N AK E +L+ + +++I Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKI---EADILKKIQNDDINNN 96 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIHSA 183 + ++ + + +E + L++II N E + + +IL+ L Y+ Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKM 156 Query: 184 NVLHRDLKPSNLLLN-------------------------ANCDLKICDFGLARVTSESD 218 ++ H DLKP N+LL+ + +K+ DFG A T +SD Sbjct: 157 SLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA--TFKSD 214 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 + + TR YRAPE++LN + + D+WS GC+ EL LF +H+ L ++ Sbjct: 215 YHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMES 273 Query: 279 LIG-TPSEEELEFLNENAKRYIRQ---LPPYPRQS--------ITDKFPTV----HPLAI 322 +I P E N +Y+ + +P + + P H L Sbjct: 274 IIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHELFC 333 Query: 323 DLIEKMLTFDPRRRITVLDALAHPYL 348 D + +L DP R + + L H +L Sbjct: 334 DFLYSILQIDPTLRPSPAELLKHKFL 359 >3NYO-A nrPDB Length = 576 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 121/290 (41%), Gaps = 35/290 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHMDHENIVAIRD 127 +GKG +G VC+ T + A KK+ K + L E ++L ++ +V++ Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++A V D H E ++ +I GL+ +H +++ Sbjct: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLKP N+LL+ + ++I D GLA E + V T Y APE++ N YT + D Sbjct: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDW 368 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 W++GC+ E++ + F R + E +R ++++P Sbjct: 369 WALGCLLYEMIAGQSPFQQRKK-------------------KIKREEVERLVKEVP---- 405 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA-----HPYLNSLH 352 + +++F P A L ++L DP R+ A HP L+ Sbjct: 406 EEYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >4YHJ-A nrPDB Length = 584 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 104/235 (44%), Gaps = 4/235 (1%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHMDHENIVAIRD 127 +GKG +G VC+ T + A KK+ K + L E ++L + +V++ Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL-- 250 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++A V D H N E+ ++ ++ GL+ + +++ Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 RDLKP N+LL+ ++I D GLA E + V T Y APE ++N+ YT + D Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPE-VVNNEKYTFSPDW 369 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 W +GC+ E++ F + + + I +EE E +E+AK R L Sbjct: 370 WGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424 >4AN9-A nrPDB Length = 301 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 101/201 (50%), Gaps = 24/201 (11%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIK----KIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G G G+V + + +A K +I A N+I +RE+++L + Sbjct: 14 ISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECNSPY 68 Query: 122 IVAIRDIIPPPLRNAF---NDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 177 IV AF ++ I E MD L Q+++ + E+ +++GL Sbjct: 69 IVG--------FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 120 Query: 178 KYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ + + E+V TR Y +PE L Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPE-RL 178 Query: 237 NSSDYTAAIDVWSVGCIFMEL 257 + Y+ D+WS+G +E+ Sbjct: 179 QGTHYSVQSDIWSMGLSLVEM 199 >3IO7-A nrPDB Length = 313 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 103/218 (47%), Gaps = 24/218 (11%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIV--C--SAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 N+ + ++ + +GKG +G V C + T E VA+KK+ ++ + + + R Sbjct: 21 NMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL--RDFER 78 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDV--YIAYELMDTDLHQIIRSNQALSEEHCQ 167 EI++L+ + H+NIV + + R + Y+ Y + L + + + Sbjct: 79 EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KHKERIDHIKLL 135 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR 227 + QI +G++Y+ + +HRDL N+L+ +KI DFGL +V + EY + Sbjct: 136 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD---KEYYKVK 192 Query: 228 --------WYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 WY APE L S ++ A DVWS G + EL Sbjct: 193 EPGESPIFWY-APE-SLTESKFSVASDVWSFGVVLYEL 228 >2W1I-A nrPDB Length = 326 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 24/207 (11%) Query: 66 IMPIGKGAYGIV--C--SAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 + +GKG +G V C + T E VA+KK+ ++ + + + REI++L+ + H+N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL--RDFEREIEILKSLQHDN 103 Query: 122 IVAIRDIIPPPLRNAFNDV--YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 IV + + R + Y+ Y + L + + + + QI +G++Y Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KHKERIDHIKLLQYTSQICKGMEY 160 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--------WYRA 231 + + +HRDL N+L+ +KI DFGL +V + EY + WY A Sbjct: 161 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD---KEYYKVKEPGESPIFWY-A 216 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELM 258 PE L S ++ A DVWS G + EL Sbjct: 217 PE-SLTESKFSVASDVWSFGVVLYELF 242 >2HK5-A nrPDB Length = 270 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 106/216 (49%), Gaps = 21/216 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V A ++ + VA+K + + + L E +++ + H+ +V + + Sbjct: 23 LGAGQFGEVWMATYNK-HTKVAVKTMK---PGSMSVEAFLAEANVMKTLQHDKLVKLHAV 78 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQY--FLYQILRGLKYIHSANV 185 + +YI E M L ++S++ + + F QI G+ +I N Sbjct: 79 VTK------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 132 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDYT 242 +HRDL+ +N+L++A+ KI DFGLARV ++++ +W APE +N +T Sbjct: 133 IHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKW-TAPE-AINFGSFT 190 Query: 243 AAIDVWSVGCIFMELM--DRKPLFPGRDHVHQLRLL 276 DVWS G + ME++ R P +PG + +R L Sbjct: 191 IKSDVWSFGILLMEIVTYGRIP-YPGMSNPEVIRAL 225 >3HDN-A nrPDB Length = 373 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 100/208 (48%), Gaps = 18/208 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IGKG++G V A + A+K + K+ + + K +H+ E V ++++ Sbjct: 46 IGKGSFGKVLLARHKAEEVFYAVKVLQ---------KKAILKKKEEKHIMSERNVLLKNV 96 Query: 129 IPP---PLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 P L +F Y ++D +L ++ + E +++ +I L Y+H Sbjct: 97 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 156 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAPELLLNSSD 240 S N+++RDLKP N+LL++ + + DFGL + E + T + T Y APE +L+ Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE-VLHKQP 215 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRD 268 Y +D W +G + E++ P F R+ Sbjct: 216 YDRTVDWWCLGAVLYEMLYGLPPFYSRN 243 >5B2L-A nrPDB Length = 324 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/196 (30%), Positives = 93/196 (47%), Gaps = 13/196 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHENIVAIRD 127 +G G G V +T +A+K++ + NK + KR L ++ + L+ D IV Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GNKEENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA-NV 185 + N DV+IA ELM T ++ + Q + E I++ L Y+ V Sbjct: 84 TF---ITN--TDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGV 138 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL----LNSSDY 241 +HRD+KPSN+LL+ +K+CDFG++ +S T Y APE + DY Sbjct: 139 IHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDY 198 Query: 242 TAAIDVWSVGCIFMEL 257 DVWS+G +EL Sbjct: 199 DIRADVWSLGISLVEL 214 >3DAK-A nrPDB Length = 290 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 94/204 (46%), Gaps = 21/204 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA---- 124 IG GA +V +A + E VAIK+I N + L+EI+ + H NIV+ Sbjct: 18 IGSGATAVVQAAYCAPKKEKVAIKRI-NLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTS 76 Query: 125 --IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKY 179 ++D + ++ + ++D H + + L E L ++L GL+Y Sbjct: 77 FVVKDELWLVMK-----LLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEY 131 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE------YVVTRWYRAPE 233 +H +HRD+K N+LL + ++I DFG++ + +T +V T + APE Sbjct: 132 LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPE 191 Query: 234 LLLNSSDYTAAIDVWSVGCIFMEL 257 ++ Y D+WS G +EL Sbjct: 192 VMEQVRGYDFKADIWSFGITAIEL 215 >2PMN-X nrPDB Length = 348 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 132/285 (46%), Gaps = 56/285 (19%) Query: 85 TNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAY 144 N+ ++IK + F N E++++ + +E + II +++VYI Y Sbjct: 77 NNDKISIKSKYDDFKN---------ELQIITDIKNEYCLTCEGIIT-----NYDEVYIIY 122 Query: 145 ELMDTDLHQIIRSNQ---ALSEEHCQYFLYQILR--------GLKYIHS-ANVLHRDLKP 192 E M+ D I++ ++ L + + + Q+++ YIH+ N+ HRD+KP Sbjct: 123 EYMEND--SILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKP 180 Query: 193 SNLLLNANCDLKICDFGLARVTSESDFMTEYVV-----TRWYRAPELLLNSSDYTAA-ID 246 SN+L++ N +K+ DFG ES++M + + T + PE N S Y A +D Sbjct: 181 SNILMDKNGRVKLSDFG------ESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVD 234 Query: 247 VWSVG-CIFMELMDRKPLFPGRDHVHQLRL-LMELIGTPSEEELEF-LNENAKRYIRQLP 303 +WS+G C+++ + P L++ L+EL + +E+ L+ N Y Sbjct: 235 IWSLGICLYVMFYNVVPF--------SLKISLVELFNNIRTKNIEYPLDRNHFLY----- 281 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P + T + ID ++ L +P RIT DAL H +L Sbjct: 282 PLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEWL 326 >3PPZ-A nrPDB Length = 309 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 97/195 (49%), Gaps = 13/195 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT---LREIKLLRHMDHENIVAI 125 IG G++G V A ++ +V I + A+R LRE+ +++ + H NIV Sbjct: 45 IGAGSFGTVHRAEWHGSDVAVKI-----LMEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN- 184 + P + Y++ + LH+ + + L E Y + +G+ Y+H+ N Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKS-GAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 185 -VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV-TRWYRAPELLLNSSDYT 242 ++HRDLK NLL++ +K+CDFGL+R+ + + ++ T + APE+L + Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNE 218 Query: 243 AAIDVWSVGCIFMEL 257 + DV+S G I EL Sbjct: 219 KS-DVYSFGVILWEL 232 >5DBX-A nrPDB Length = 328 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 19/203 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA---- 124 IG GA +V +A+ E VAIK+I N + L+EI+ + H N+V Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRI-NLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTS 77 Query: 125 --IRD--IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 ++D + L + + + I +++ H+ N L E L ++L GL Y+ Sbjct: 78 FVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHK----NGVLEEAIIATILKEVLEGLDYL 133 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT------EYVVTRWYRAPEL 234 H +HRDLK N+LL + ++I DFG++ + +T ++V T + APE+ Sbjct: 134 HRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEV 193 Query: 235 LLNSSDYTAAIDVWSVGCIFMEL 257 + Y D+WS G +EL Sbjct: 194 MEQVRGYDFKADMWSFGITAIEL 216 >2Y6O-A nrPDB Length = 291 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 94/200 (47%), Gaps = 18/200 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VCS + + VAIK + + +K + L E ++ DH NI+ + Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-QRRDFLSEASIMGQFDHPNIIHL 80 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R N + L I G+KY+ Sbjct: 81 EGVV-----TKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM 135 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTS---ESDFMTE--YVVTRWYRAPELLLNS 238 + +HRDL N+L+N+N K+ DFG++RV E+ + T + RW APE + Sbjct: 136 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW-TAPEAIAYR 194 Query: 239 SDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 195 K-FTSASDVWSYGIVMWEVM 213 >2JD5-A nrPDB Length = 373 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 86/330 (26%), Positives = 145/330 (43%), Gaps = 63/330 (19%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-----HE 120 + +G G + V A + N VA+K + +K+ + EIKLL+ ++ E Sbjct: 24 VRKLGWGHFSTVWLAKDMVNNTHVAMKIVRG---DKVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 121 NIVAIRDIIPPPLRNAFND-------VYIAYELMDTDLHQIIRS--NQALSEEHCQYFLY 171 + + I+ L + FN V + +E++ +L +I+ ++ + + + Sbjct: 81 DSMGANHILK--LLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISK 138 Query: 172 QILRGLKYIHS-ANVLHRDLKPSNLLLNAN------CDLKICDFGLARVTSESDFMTEYV 224 Q+L GL Y+H ++H D+KP N+L+ +KI D G A E T + Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH--YTNSI 196 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF---------PGRDHVHQLRL 275 TR YR+PE+LL + + D+WS C+ EL+ LF DH+ Q+ Sbjct: 197 QTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQI-- 253 Query: 276 LMELIGT-PSEEELEFLNENAK------------RYIRQLPPYPRQSI-TDKFPTVHPLA 321 +EL+G PS +L N K R I +L +P + + T+K+ A Sbjct: 254 -IELLGELPS-----YLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEA 307 Query: 322 ---IDLIEKMLTFDPRRRITVLDALAHPYL 348 D + ML DPR+R + HP+L Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWL 337 >4RA4-A nrPDB Length = 355 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 105/227 (46%), Gaps = 30/227 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +M +GKG++G V A T E AIK + + D + T+ E ++L +D Sbjct: 25 LMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK----- 79 Query: 125 IRDIIPP---PLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGL 177 PP L + F V Y +M+ DL I+ E ++ +I GL Sbjct: 80 -----PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW------YRA 231 ++H +++RDLK N++L++ +KI DFG+ + + M + V TR Y A Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----EHMMDGVTTRTFCGTPDYIA 189 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 PE++ Y ++D W+ G + E++ +P F G D + +ME Sbjct: 190 PEIIAYQP-YGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >5X5O-A nrPDB Length = 310 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 105/214 (49%), Gaps = 21/214 (9%) Query: 70 GKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDII 129 G G++G V A ++ VA+KK+ KI+ +E ++L + H NI+ +I Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLL-----KIE-----KEAEILSVLSHRNIIQFYGVI 73 Query: 130 PPPLRNAFNDVYIAYELMDTDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYIHS---AN 184 P Y + L+ I SN++ + +H + + +G+ Y+H Sbjct: 74 LEPPNYGIVTEYASL----GSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 129 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 V+HRDLK N+++ A+ LKICDFG +R + + M+ V T + APE ++ S + Sbjct: 130 VIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPE-VIQSLPVSET 187 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 D +S G + E++ R+ F G + + L++E Sbjct: 188 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE 221 >5X3F-B nrPDB Length = 393 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 99/205 (48%), Gaps = 18/205 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV-- 123 I +G G++G V + E+ N + KI K+ + ++K + H +E + Sbjct: 89 IKTLGTGSFGRVMLVKHKES---------GNHYAMKILDKQKVVKLKQIEHTLNEKRILQ 139 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 A+ L +F D Y +M+ ++ +R SE H +++ QI+ +Y Sbjct: 140 AVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 199 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 +HS ++++RDLKP NLL++ +++ DFG A+ + T Y APE++L S Sbjct: 200 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEIIL-SK 256 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLF 264 Y A+D W++G + E+ P F Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPF 281 >4PDO-A nrPDB Length = 299 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 93/202 (46%), Gaps = 21/202 (10%) Query: 69 IGKGAYGIVCSAM----NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 IG G +G V M + + VAIK + + K L E ++ H NI+ Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVD-FLGEAGIMGQFSHHNIIR 100 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHS 182 + +I + + + I E M+ L + +R S L I G+KY+ + Sbjct: 101 LEGVI-----SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLAN 155 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT------RWYRAPELLL 236 N +HRDL N+L+N+N K+ DFGL+RV E D Y + RW APE + Sbjct: 156 MNYVHRDLAARNILVNSNLVCKVSDFGLSRVL-EDDPEATYTTSGGKIPIRW-TAPE-AI 212 Query: 237 NSSDYTAAIDVWSVGCIFMELM 258 + +T+A DVWS G + E+M Sbjct: 213 SYRKFTSASDVWSFGIVMWEVM 234 >6DBN-A nrPDB Length = 316 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 27/209 (12%) Query: 66 IMPIGKGAYGIV--C--SAMNSETNESVAIKKIA--NAFDNKIDAKRTLREIKLLRHMDH 119 I +G+G +G V C T E VA+K + + ++ D K+ EI++LR++ H Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK---EIEILRNLYH 96 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQ-ALSEEHCQYFLYQILRGL 177 ENIV + I + N + + E + + L + + N+ ++ + + QI +G+ Sbjct: 97 ENIVKYKGICT---EDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGM 153 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--------WY 229 Y+ S +HRDL N+L+ + +KI DFGL + E+D EY + WY Sbjct: 154 DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAI-ETD--KEYYTVKDDRDSPVFWY 210 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELM 258 APE L+ S Y A+ DVWS G EL+ Sbjct: 211 -APECLMQSKFYIAS-DVWSFGVTLHELL 237 >4WUA-A nrPDB Length = 401 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 88/360 (24%), Positives = 143/360 (39%), Gaps = 79/360 (21%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-----HE 120 I +G G + V + + + + VA+K + +A A +R +K +R+ D E Sbjct: 46 IRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNRE 105 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKY 179 +V + D N + + L L II+SN Q L + + Q+L+GL Y Sbjct: 106 MVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDY 165 Query: 180 IHS-ANVLHRDLKPSNLLLNAN-------------------------------------- 200 +H+ ++H D+KP N+LL+ N Sbjct: 166 LHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFL 225 Query: 201 -----------CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWS 249 +KI D G A + TE + TR YR+ E+L+ S Y D+WS Sbjct: 226 VNPLEPKNAEKLKVKIADLGNACWVHKH--FTEDIQTRQYRSLEVLIGSG-YNTPADIWS 282 Query: 250 VGCIFMELMDRKPLFP-------GRDHVHQLRLLMELIG-------TPSEEELEFLNENA 295 C+ EL LF RD H + L++EL+G + EF + Sbjct: 283 TACMAFELATGDYLFEPHSGEEYTRDEDH-IALIIELLGKVPRKLIVAGKYSKEFFTKKG 341 Query: 296 K-RYIRQLPPYPR-QSITDKFPTVHPLA---IDLIEKMLTFDPRRRITVLDALAHPYLNS 350 ++I +L P+ + + +K+ A D + ML P +R T + L HP+LNS Sbjct: 342 DLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 401 >4PL5-B nrPDB Length = 435 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 94/313 (30%), Positives = 135/313 (43%), Gaps = 61/313 (19%) Query: 69 IGKGAYG-IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIR 126 +G GA G IV M N VA+K+I + D RE++LLR D H N+ IR Sbjct: 35 LGHGAEGTIVYKGMFD--NRDVAVKRILPECFSFAD-----REVQLLRESDEHPNV--IR 85 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIHSAN 184 R YIA EL L + + L E L+Q GL ++HS N Sbjct: 86 YFCTEKDRQF---QYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLHQTTSGLAHLHSLN 141 Query: 185 VLHRDLKPSNLLL---NANCDLK--ICDFGLAR--VTSESDFMTEYVV--TRWYRAPELL 235 ++HRDLKP N+LL NA+ +K I DFGL + F V T + APE+L Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 236 LN--SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 + T +D++S GC+F ++ G+ Q +L+ L+ + Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACN------LDCFH- 254 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL-- 351 +DK V +A +LIEKM+ DP++R + L HP+ SL Sbjct: 255 -----------------SDKHEDV--IARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEK 295 Query: 352 -----HDISDEPE 359 D+SD E Sbjct: 296 QLQFFQDVSDRIE 308 >1FOT-A nrPDB Length = 318 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 95/198 (47%), Gaps = 22/198 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G++G V + A+K + K + +K + H + E ++ I Sbjct: 14 LGTGSFGRVHLIRSRHNGRYYAMKVLK---------KEIVVRLKQVEHTNDERLML--SI 62 Query: 129 IPPP----LRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 + P + F D + +MD +L ++R +Q +++ ++ L+Y+ Sbjct: 63 VTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 HS ++++RDLKP N+LL+ N +KI DFG A+ + + T Y APE ++++ Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTL--CGTPDYIAPE-VVSTKP 179 Query: 241 YTAAIDVWSVGCIFMELM 258 Y +ID WS G + E++ Sbjct: 180 YNKSIDWWSFGILIYEML 197 >5TUR-A nrPDB Length = 404 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 97/197 (49%), Gaps = 11/197 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + + R E+ LL+ + + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 195 IRLLDWFERP--DSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQVLEAVRHCHN 251 Query: 183 ANVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ N +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 252 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 310 Query: 242 TAAIDVWSVGCIFMELM 258 + VWS+G + +++ Sbjct: 311 GRSAAVWSLGILLYDMV 327 >5O2C-A nrPDB Length = 380 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 22/220 (10%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 S GRF++++I +G+GA+ V +++ET VA ++ + Sbjct: 21 SPSGRFLKFDI----------------ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLT 64 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 K + +R E ++L+ + H NIV D L+ V + + L ++ + Sbjct: 65 KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV 124 Query: 161 LSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSES 217 + + + + QIL+GL+++H+ ++HRDLK N+ + +KI D GLA + S Sbjct: 125 MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS 184 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 F + T + APE+ Y ++DV++ G +E+ Sbjct: 185 -FAKSVIGTPEFMAPEMY--EEHYDESVDVYAFGMCMLEM 221 >5O2B-A nrPDB Length = 285 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 22/220 (10%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 S GRF++++I +G+GA+ V +++ET VA ++ + Sbjct: 12 SPSGRFLKFDI----------------ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLT 55 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 K + +R E ++L+ + H NIV D L+ V + + L ++ + Sbjct: 56 KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV 115 Query: 161 LSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSES 217 + + + + QIL+GL+++H+ ++HRDLK N+ + +KI D GLA + S Sbjct: 116 MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS 175 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 F + T + APE+ Y ++DV++ G +E+ Sbjct: 176 -FAKSVIGTPEFMAPEMY--EEHYDESVDVYAFGMCMLEM 212 >3A8W-A nrPDB Length = 345 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/307 (22%), Positives = 135/307 (43%), Gaps = 38/307 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAF---DNKIDAKRTLREIKLLRHMDHENIVAI 125 IG+G+Y V +T+ A+K + D ID +T + + + +H +V + Sbjct: 17 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHV-FEQASNHPFLVGL 75 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 R F Y+ DL ++ + L EEH +++ +I L Y+H + Sbjct: 76 HSCFQTESRLFFVIEYVN----GGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI 131 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSE-SDFMTEYVVTRWYRAPELLLNSSDYTAA 244 ++RDLK N+LL++ +K+ D+G+ + D + + T Y APE +L DY + Sbjct: 132 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE-ILRGEDYGFS 190 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D W++G + E+M + F +++G+ ++N + Y+ Q+ Sbjct: 191 VDWWALGVLMFEMMAGRSPF-------------DIVGSSDNP-----DQNTEDYLFQVIL 232 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV------LDALAHPYLNSLH-DISDE 357 + I ++ A +++ L DP+ R+ D HP+ ++ D+ ++ Sbjct: 233 EKQIRIP---RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQ 289 Query: 358 PECTIPF 364 + PF Sbjct: 290 KQVVPPF 296 >3C51-A nrPDB Length = 543 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/193 (27%), Positives = 90/193 (46%), Gaps = 28/193 (14%) Query: 151 LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 ++ + N E ++ QI+ GL+++H N+++RDLKP N+LL+ + +++I D GL Sbjct: 276 IYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGL 335 Query: 211 ARVTSESDFMTE-YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 A T+ Y T + APELLL +Y ++D +++G E++ + F R Sbjct: 336 AVELKAGQTKTKGYAGTPGFMAPELLLG-EEYDFSVDYFALGVTLYEMIAARGPFRAR-- 392 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 G E + E +R + Q YP DKF P + D E +L Sbjct: 393 -----------GEKVENK-----ELKQRVLEQAVTYP-----DKF---SPASKDFCEALL 428 Query: 330 TFDPRRRITVLDA 342 DP +R+ D Sbjct: 429 QKDPEKRLGFRDG 441 >2R2P-A nrPDB Length = 295 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 18/200 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VCS + + VAIK + + K + L E ++ DH NI+ + Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK-QRRDFLGEASIMGQFDHPNIIHL 88 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L ++ N + L I G+KY+ Sbjct: 89 EGVVTKS-----KPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 143 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTS---ESDFMTE--YVVTRWYRAPELLLNS 238 +HRDL N+L+N+N K+ DFGL+RV E+ + T + RW APE + Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TAPEAIAFR 202 Query: 239 SDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E++ Sbjct: 203 K-FTSASDVWSYGIVMWEVV 221 >5UUU-A nrPDB Length = 547 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 99/199 (49%), Gaps = 19/199 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLRE---IKLLRHMDHENIVA 124 IG+G +G V ++T + A+K + K L E + L+ D IV Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + P + +F +LM+ DLH + + SE +++ +I+ GL+++H+ Sbjct: 266 MSYAFHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 320 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----YVVTRWYRAPELLLNSS 239 V++RDLKP+N+LL+ + ++I D GLA DF + V T Y APE+L Sbjct: 321 FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMAPEVLQKGV 375 Query: 240 DYTAAIDVWSVGCIFMELM 258 Y ++ D +S+GC+ +L+ Sbjct: 376 AYDSSADWFSLGCMLFKLL 394 >4RC3-A nrPDB Length = 289 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 97/197 (49%), Gaps = 11/197 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + + R E+ LL+ + + Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 80 IRLLDWFERP--DSFVLILERPEPV-QDLFDFITERGALQEELARSFFWQVLEAVRHCHN 136 Query: 183 ANVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ N +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 137 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 195 Query: 242 TAAIDVWSVGCIFMELM 258 + VWS+G + +++ Sbjct: 196 GRSAAVWSLGILLYDMV 212 >6HV0-A nrPDB Length = 416 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 93/313 (29%), Positives = 134/313 (42%), Gaps = 61/313 (19%) Query: 69 IGKGAYG-IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIR 126 +G GA G IV M N VA+K+I + D RE++LLR D H N+ IR Sbjct: 16 LGHGAEGTIVYRGMFD--NRDVAVKRILPECFSFAD-----REVQLLRESDEHPNV--IR 66 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIHSAN 184 R YIA EL L + + L E L Q GL ++HS N Sbjct: 67 YFCTEKDRQF---QYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLQQTTSGLAHLHSLN 122 Query: 185 VLHRDLKPSNLLL---NANCDLK--ICDFGLAR--VTSESDFMTEYVV--TRWYRAPELL 235 ++HRDLKP N+L+ NA+ +K I DFGL + F V T + APE+L Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 182 Query: 236 LN--SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 + T +D++S GC+F ++ G+ Q +L+ G S Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILL---GACS--------- 230 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL-- 351 + L P + + +A +LIEKM+ DP++R + L HP+ SL Sbjct: 231 -----LDCLHPEKHEDV---------IARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 276 Query: 352 -----HDISDEPE 359 D+SD E Sbjct: 277 QLQFFQDVSDRIE 289 >3BGP-A nrPDB Length = 333 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 97/197 (49%), Gaps = 11/197 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + + R E+ LL+ + + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 124 IRLLDWFERP--DSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQVLEAVRHCHN 180 Query: 183 ANVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ N +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 181 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 239 Query: 242 TAAIDVWSVGCIFMELM 258 + VWS+G + +++ Sbjct: 240 GRSAAVWSLGILLYDMV 256 >6CTH-A nrPDB Length = 309 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 17/197 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G +G V +++ +A+KK++ A +K K E+K++ + H+N+V + Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRLRHKNLVKLIGW 80 Query: 129 IPPPLRNAFNDVYIAYELM---DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN- 184 + ++ + YE M D H I + L+ E + + L Y+H Sbjct: 81 C-----HERGELMLVYEFMANGSLDSH-IFKGKSLLTWEVRYRIVKDLASALLYLHEEGD 134 Query: 185 --VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPELLLNSSD 240 VLHRD+K SN++L+++ + K+ DFGLAR+ + + + ++ T Y APE L+S Sbjct: 135 HCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPE-CLSSGK 193 Query: 241 YTAAIDVWSVGCIFMEL 257 + DV+S G + +E+ Sbjct: 194 ASKESDVYSFGVVALEI 210 >3PVW-A nrPDB Length = 695 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 99/199 (49%), Gaps = 19/199 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLRE---IKLLRHMDHENIVA 124 IG+G +G V ++T + A+K + K L E + L+ D IV Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + P + +F +LM+ DLH + + SE +++ +I+ GL+++H+ Sbjct: 257 MSYAFHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY----VVTRWYRAPELLLNSS 239 V++RDLKP+N+LL+ + ++I D GLA DF + V T Y APE+L Sbjct: 312 FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMAPEVLQKGV 366 Query: 240 DYTAAIDVWSVGCIFMELM 258 Y ++ D +S+GC+ +L+ Sbjct: 367 AYDSSADWFSLGCMLFKLL 385 >2X7G-A nrPDB Length = 389 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 88/359 (24%), Positives = 146/359 (40%), Gaps = 79/359 (22%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-----HE 120 I +G G + V + + VA+K + +A A ++ +K +R D + Sbjct: 36 IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD 95 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDL-HQIIRSN-QALSEEHCQYFLYQILRGLK 178 +V + D N + V + +E++ L II+SN Q L + + Q+L+GL Sbjct: 96 MVVQLIDDFKISGMNGIH-VCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLD 154 Query: 179 YIHS-ANVLHRDLKPSNLLLNA-------------------------------------- 199 Y+HS ++H D+KP N+L+ Sbjct: 155 YLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLV 214 Query: 200 ------NCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSV 250 N D +KI D G A + TE + TR YR+ E+L+ + Y+ D+WS Sbjct: 215 NPLDPRNADKIRVKIADLGNACWVHKH--FTEDIQTRQYRSIEVLIGAG-YSTPADIWST 271 Query: 251 GCIFMELMDRKPLFP-------GRDHVHQLRLLMELIGT-------PSEEELEFLNENAK 296 C+ EL LF RD H + ++EL+G+ + EF N + Sbjct: 272 ACMAFELATGDYLFEPHSGEDYSRDEDH-IAHIIELLGSIPRHFALSGKYSREFFNRRGE 330 Query: 297 -RYIRQLPPYPR-QSITDKFPTVHPLA---IDLIEKMLTFDPRRRITVLDALAHPYLNS 350 R+I +L P+ + +K+ H A D + ML P +R + + L HP+LNS Sbjct: 331 LRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >1AD5-A nrPDB Length = 438 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 104/213 (48%), Gaps = 25/213 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V A ++ + VA+K + + + L E +++ + H+ +V + + Sbjct: 190 LGAGQFGEVWMATYNK-HTKVAVKTMKPG---SMSVEAFLAEANVMKTLQHDKLVKLHAV 245 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQY--FLYQILRGLKYIHSANV 185 + +YI E M L ++S++ + + F QI G+ +I N Sbjct: 246 VTK------EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 299 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 +HRDL+ +N+L++A+ KI DFGLARV ++ +W APE +N +T Sbjct: 300 IHRDLRAANILVSASLVCKIADFGLARVGAK-------FPIKW-TAPE-AINFGSFTIKS 350 Query: 246 DVWSVGCIFMELM--DRKPLFPGRDHVHQLRLL 276 DVWS G + ME++ R P +PG + +R L Sbjct: 351 DVWSFGILLMEIVTYGRIP-YPGMSNPEVIRAL 382 >4U41-A nrPDB Length = 332 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 98/206 (47%), Gaps = 17/206 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G YG V + +T + AIK + D + + K + +K H H NI Sbjct: 32 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH--HRNIATYYGA 89 Query: 129 I---PPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 PP + + +++ E TDL + + N L E+ Y +ILRGL ++H Sbjct: 90 FIKKSPPGHD--DQLWLVMEFCGAGSITDLVKNTKGN-TLKEDWIAYISREILRGLAHLH 146 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 +V+HRD+K N+LL N ++K+ DFG+ A++ ++ T ++ APE++ + Sbjct: 147 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 206 Query: 241 ----YTAAIDVWSVGCIFMELMDRKP 262 Y D+WS G +E+ + P Sbjct: 207 PDATYDYRSDLWSCGITAIEMAEGAP 232 >3CJF-A nrPDB Length = 309 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 42/220 (19%) Query: 68 PIGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE-N 121 P+G+GA+G V A + T +VA+K + + + + + E+K+L H+ H N Sbjct: 34 PLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHS-EHRALMSELKILIHIGHHLN 92 Query: 122 IVAIRDIIPPP-------------------LRNAFNDVYIAYELMDTDLHQIIRSNQALS 162 +V + P LR+ N+ ++ Y+ + D L+ Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNE-FVPYKDLYKDF---------LT 142 Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMT 221 EH + +Q+ +G++++ S +HRDL N+LL+ +KICDFGLAR + + D++ Sbjct: 143 LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR 202 Query: 222 E---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + + +W APE + + YT DVWS G + E+ Sbjct: 203 KGDARLPLKWM-APETIFDRV-YTIQSDVWSFGVLLWEIF 240 >4G3E-A nrPDB Length = 352 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 100/205 (48%), Gaps = 33/205 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G++G V + +T A+KK+ +++ R E +VA + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKV------RLEVFRV------------EELVACAGL 123 Query: 129 IPP---PLRNAFND---VYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 P PL A + V I EL++ L Q+I+ L E+ Y+L Q L GL+Y+H Sbjct: 124 SSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLH 183 Query: 182 SANVLHRDLKPSNLLLNANCD-LKICDFGLARV-----TSESDFMTEYV-VTRWYRAPEL 234 + +LH D+K N+LL+++ +CDFG A +S +Y+ T + APE+ Sbjct: 184 TRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEV 243 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMD 259 ++ A +D+WS C+ + +++ Sbjct: 244 VMGKP-CDAKVDIWSSCCMMLHMLN 267 >5MJB-A nrPDB Length = 305 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 91/202 (45%), Gaps = 20/202 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G V + + VAIK + + K + L E ++ DH NI+ + Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK-QRRDFLSEASIMGQFDHRNIIRL 92 Query: 126 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R N + L I G+KY+ Sbjct: 93 EGVVTKS-----RPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEM 147 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARV----TSESDFMTEY---VVTRWYRAPELLL 236 N +HRDL N+L+N+N K+ DFGL+R TS+ + + + RW APE + Sbjct: 148 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPEAIA 206 Query: 237 NSSDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 207 YRK-FTSASDVWSYGIVMWEVM 227 >5VO2-A nrPDB Length = 300 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 90/190 (47%), Gaps = 16/190 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G GA G V + E VA+KK+ D K T +IK LR + H NI+ + + Sbjct: 20 VGSGAQGAV--FLGRFHGEEVAVKKVR-------DLKET--DIKHLRKLKHPNIITFKGV 68 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 + A L++++R+ + ++ + I G+ Y+H ++HR Sbjct: 69 CTQAPCYCILMEFCA----QGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHR 124 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVW 248 DLK N+L+ + +KI DFG ++ S+ + T + APE++ N + +D+W Sbjct: 125 DLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP-VSEKVDIW 183 Query: 249 SVGCIFMELM 258 S G + EL+ Sbjct: 184 SFGVVLWELL 193 >2VWV-A nrPDB Length = 302 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 90/202 (44%), Gaps = 20/202 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VC + VAIK + + + + L E ++ +H NI+ + Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER-QRREFLSEASIMGQFEHPNIIRL 82 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ + V I E M+ L +R N + L I G++Y+ Sbjct: 83 EGVVTNSM-----PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM 137 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVT-------SESDFMTEYVVTRWYRAPELLL 236 + +HRDL N+L+N+N K+ DFGL+R +E+ + + RW APE + Sbjct: 138 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT-APEAIA 196 Query: 237 NSSDYTAAIDVWSVGCIFMELM 258 +T+A D WS G + E+M Sbjct: 197 -FRKFTSASDAWSYGIVMWEVM 217 >4E20-A nrPDB Length = 290 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 96/210 (45%), Gaps = 21/210 (10%) Query: 61 KYKPPIMPIGKGAYGIVC----SAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 +Y I +G+G +G V N T E VA+K + ++ + REI++LR Sbjct: 8 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILRT 66 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 + HE+IV + + V + Y + + + R L++ F QI G Sbjct: 67 LYHEHIVKYKGCCEDQGEKSVQLV-MEYVPLGSLRDYLPRHCVGLAQ--LLLFAQQICEG 123 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--------W 228 + Y+H+ + +HR L N+LL+ + +KI DFGLA+ E EY R W Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGDSPVFW 180 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 Y APE L Y A+ DVWS G EL+ Sbjct: 181 Y-APECLKECKFYYAS-DVWSFGVTLYELL 208 >5L6P-A nrPDB Length = 298 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 89/202 (44%), Gaps = 20/202 (9%) Query: 69 IGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G +G VC + VAIK + + + + L E ++ DH NI+ + Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTER-QRRDFLSEASIMGQFDHPNIIRL 85 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 ++ V I E M+ L +R N + L I G+KY+ Sbjct: 86 EGVVTKS-----RPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM 140 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSE-------SDFMTEYVVTRWYRAPELLL 236 N +HRDL N+L+N+N K+ DFGL+R + + + + RW APE + Sbjct: 141 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT-APEAIA 199 Query: 237 NSSDYTAAIDVWSVGCIFMELM 258 +T+A DVWS G + E+M Sbjct: 200 YRK-FTSASDVWSYGIVMWEVM 220 >6DBM-A nrPDB Length = 318 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 98/211 (46%), Gaps = 23/211 (10%) Query: 61 KYKPPIMPIGKGAYGIVC----SAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLR 115 +Y I +G+G +G V N T E VA+K + A+A + +EI +LR Sbjct: 31 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK--QEIDILR 88 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILR 175 + HE+I+ + + V + Y + + + R + L++ F QI Sbjct: 89 TLYHEHIIKYKGCCEDAGAASLQLV-MEYVPLGSLRDYLPRHSIGLAQ--LLLFAQQICE 145 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR-------- 227 G+ Y+HS + +HRDL N+LL+ + +KI DFGLA+ E EY R Sbjct: 146 GMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGDSPVF 202 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 WY APE L Y A+ DVWS G EL+ Sbjct: 203 WY-APECLKEYKFYYAS-DVWSFGVTLYELL 231 >5GRN-A nrPDB Length = 356 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 111/222 (50%), Gaps = 37/222 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAF----DNKIDAKRTLREIKLLRHMD-HENIV 123 +G GA+G V + S + K+A + + + E+K++ H+ H NIV Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIV 113 Query: 124 AI-------------------RDIIPPPLRNAFNDVYIAYE---LMDTDLHQIIR--SNQ 159 + D++ +N D +++++ ++D+++ ++ +++ Sbjct: 114 NLLGACTKSGPIYIITEYCFYGDLVNYLHKN--RDSFLSHKKKSMLDSEVKNLLSDDNSE 171 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESD 218 L+ F YQ+ RG++++ S N +HRDL N+LL +KICDFGLAR + +S+ Sbjct: 172 GLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSN 231 Query: 219 FMTE---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 ++++ ++ +W APE + ++ YT DVWS G + E+ Sbjct: 232 YVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEI 271 >5VD3-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 90/214 (42%), Gaps = 21/214 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI----VA 124 +G G+YG V + E A+K+ + F D R L E+ HE + Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG-----SHEKVGQHPCC 119 Query: 125 IRDIIPPPLRNAFND---VYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYI 180 +R L A+ + +Y+ EL L Q + +L E +L L L ++ Sbjct: 120 VR------LEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSD 240 HS ++H D+KP+N+ L K+ DFGL + Y APELL S Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-- 231 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 Y A DV+S+G +E+ L G + QLR Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLR 265 >5EG3-A nrPDB Length = 334 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 107/217 (49%), Gaps = 33/217 (15%) Query: 68 PIGKGAYG--IVCSAMNSETNE-----SVAIKKIANAFDNKIDAKRTLREIKLLRHM-DH 119 P+G+GA+G ++ A+ + ++ +VA+K + + K D + E+++++ + H Sbjct: 42 PLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK-DLSDLVSEMEMMKMIGKH 100 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-----------ALSEEHCQY 168 +NI+ +++ ++ V +AY +L + +R+ + + EE + Sbjct: 101 KNII---NLLGACTQDGPLYVIVAYA-SKGNLREYLRARRPPGMELSPDINRVPEEQMTF 156 Query: 169 -----FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 YQ+ RG++Y+ S +HRDL N+L+ N +KI DFGLAR + DF E Sbjct: 157 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKET 216 Query: 224 VVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 R + APE L + YT DVWS G + E+ Sbjct: 217 TNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEI 252 >5X02-A nrPDB Length = 347 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 44/225 (19%) Query: 69 IGKGAYGIVCSAMN---SETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENI 122 +G GA+G V +A S+T S VA+K + D+ + + + E+K++ + HENI Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSELKMMTQLGSHENI 114 Query: 123 VAIRD--IIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQY----------- 168 V + + P+ F Y Y DL +RS + SE+ +Y Sbjct: 115 VNLLGACTLSGPIYLIFE--YCCY----GDLLNYLRSKREKFSEDEIEYENQKRLEEEED 168 Query: 169 -----------FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSE 216 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + S+ Sbjct: 169 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 228 Query: 217 SDFMTE---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 S+++ + +W APE L YT DVWS G + E+ Sbjct: 229 SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 271 >4E93-A nrPDB Length = 377 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 14/194 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G +G V S N VA+K + AK L+E ++L+ H NIV + + Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGV 180 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVL 186 +YI EL+ D +R+ A L + + G++Y+ S + Sbjct: 181 C-----TQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI 235 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT----EYVVTRWYRAPELLLNSSDYT 242 HRDL N L+ LKI DFG++R ++ + V +W APE LN Y+ Sbjct: 236 HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPE-ALNYGRYS 293 Query: 243 AAIDVWSVGCIFME 256 + DVWS G + E Sbjct: 294 SESDVWSFGILLWE 307 >2DQ7-X nrPDB Length = 283 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 104/223 (46%), Gaps = 19/223 (8%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 +++E+ + I +G G +G V N VAIK + + + L E ++ Sbjct: 2 DVWEIPRESLQLIKRLGNGQFGEVWMG-TWNGNTKVAIKTLK---PGTMSPESFLEEAQI 57 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQ--ALSEEHCQYFL 170 ++ + H+ +V + ++ + +YI E M+ L ++ + AL + Sbjct: 58 MKKLKHDKLVQLYAVV------SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 111 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---R 227 Q+ G+ YI N +HRDL+ +N+L+ KI DFGLAR+ ++++ + Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIK 171 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL-FPGRDH 269 W APE L +T DVWS G + EL+ + + +PG ++ Sbjct: 172 W-TAPEAALYGR-FTIKSDVWSFGILLTELVTKGRVPYPGMNN 212 >4HVI-A nrPDB Length = 314 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 102/207 (49%), Gaps = 24/207 (11%) Query: 66 IMPIGKGAYGIV--C--SAMNSETNESVAIKKIANAF-DNKIDAKRTLREIKLLRHMDHE 120 I +GKG +G V C + T VA+K++ ++ D + D +R EI++L+ + + Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQR---EIQILKALHSD 71 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKY 179 IV R + P R + V + Y L L ++ ++A L + QI +G++Y Sbjct: 72 FIVKYRGVSYGPGRQSLRLV-MEY-LPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEY 129 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--------WYRA 231 + S +HRDL N+L+ + +KI DFGLA++ +Y V R WY A Sbjct: 130 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLP---LDKDYYVVREPGQSPIFWY-A 185 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELM 258 PE L+ + ++ DVWS G + EL Sbjct: 186 PE-SLSDNIFSRQSDVWSFGVVLYELF 211 >4XUF-A nrPDB Length = 297 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 44/225 (19%) Query: 69 IGKGAYGIVCSAMN---SETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENI 122 +G GA+G V +A S+T S VA+K + D+ + + + E+K++ + HENI Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSELKMMTQLGSHENI 75 Query: 123 VAIRD--IIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQY----------- 168 V + + P+ F Y Y DL +RS + SE+ +Y Sbjct: 76 VNLLGACTLSGPIYLIFE--YCCY----GDLLNYLRSKREKFSEDEIEYENQKRLEEEED 129 Query: 169 -----------FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSE 216 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + S+ Sbjct: 130 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 189 Query: 217 SDFMTE---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 S+++ + +W APE L YT DVWS G + E+ Sbjct: 190 SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 232 >2H8H-A nrPDB Length = 535 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 19/205 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G +G V + T VAIK + + + L+E ++++ + HE +V + + Sbjct: 275 LGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 330 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + +YI E M L ++ + + L QI G+ Y+ N Sbjct: 331 V------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 384 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDYT 242 +HRDL+ +N+L+ N K+ DFGLAR+ ++++ +W APE L +T Sbjct: 385 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPEAALYGR-FT 442 Query: 243 AAIDVWSVGCIFMELMDRKPL-FPG 266 DVWS G + EL + + +PG Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPG 467 >3QD2-B nrPDB Length = 332 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/263 (23%), Positives = 111/263 (42%), Gaps = 71/263 (26%) Query: 65 PIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV- 123 PI +G+G +G+V A N + + AIK+I + ++ ++ +RE+K L ++H IV Sbjct: 10 PIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGIVR 68 Query: 124 ---AIRDIIPPPLRNAFNDVYIAYELMDTDLH---------------------------- 152 A + P + +++++ E D L Sbjct: 69 YFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQLQ 128 Query: 153 ------------QIIRS-------NQALS---EEH--CQYFLYQILRGLKYIHSANVLHR 188 Q+ R N+ S EH C + QI ++++HS ++HR Sbjct: 129 PSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHR 188 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSESD-------------FMTEYVVTRWYRAPELL 235 DLKPSN+ + +K+ DFGL + + T V T+ Y +PE Sbjct: 189 DLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE-Q 247 Query: 236 LNSSDYTAAIDVWSVGCIFMELM 258 ++ ++Y+ +D++S+G I EL+ Sbjct: 248 IHGNNYSHKVDIFSLGLILFELL 270 >2I0E-A nrPDB Length = 353 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 103/226 (45%), Gaps = 28/226 (12%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +M +GKG++G V + T+E A+K L++ +++ D E + Sbjct: 25 LMVLGKGSFGKVMLSERKGTDELYAVK--------------ILKKDVVIQDDDVECTMVE 70 Query: 126 RDIIPPPLRNAF-NDVYIAYELMD-----------TDLHQIIRSNQALSEEHCQYFLYQI 173 + ++ P + F ++ ++ MD DL I+ E H ++ +I Sbjct: 71 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAP 232 GL ++ S +++RDLK N++L++ +KI DFG+ + T+ + T Y AP Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 190 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 E++ Y ++D W+ G + E++ + F G D + +ME Sbjct: 191 EIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 235 >4CSV-A nrPDB Length = 275 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 35/214 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V N VA+K + + + + L+E ++++ + H N+V + + Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMKKLKHPNLVQLYGV 75 Query: 129 IP--PPLRNAFNDVYIAYELM----------DTDLHQIIRSNQALSEEHCQYFLYQILRG 176 PP +YI E M D + H + + QAL + Q+ G Sbjct: 76 CTKEPP-------IYIITEYMSHGSLLDYLRDCEGHTV--NAQALLD-----MAAQVASG 121 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPE 233 + Y+ S N +HRDL N L+ N +K+ DFGLAR+ +E ++ +W APE Sbjct: 122 MAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKW-TAPE 180 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPL-FPG 266 ++ + ++ DVW+ G + E+ + +PG Sbjct: 181 -AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPG 213 >6CKI-A nrPDB Length = 316 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 77/313 (24%), Positives = 132/313 (42%), Gaps = 42/313 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RHMDHENIVAIRD 127 +G+GA+ V + +N T++ A+K I + R RE+++L + H N++ + + Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFREVEMLYQCQGHRNVLELIE 78 Query: 128 IIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 R Y+ +E M + I + +E + + L ++H+ + Sbjct: 79 FFEEEDR-----FYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIA 133 Query: 187 HRDLKPSNLLL---NANCDLKICDFGLARV---------TSESDFMTEYVVTRWYRAPEL 234 HRDLKP N+L N +KICDFGL S + +T Y APE+ Sbjct: 134 HRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAE-YMAPEV 192 Query: 235 L----LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 + +S Y D+WS+G I L+ P F GR E P+ + + F Sbjct: 193 VEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE--ACPACQNMLF 250 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + +Y +P + + + A DLI K+L D ++R++ L HP++ Sbjct: 251 ESIQEGKY-----EFPDKD----WAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 301 Query: 351 LHDISDEPECTIP 363 PE T+P Sbjct: 302 C-----APENTLP 309 >4UY9-A nrPDB Length = 323 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 98/214 (45%), Gaps = 24/214 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAIR 126 IG G +G V A + VA+K + D I + +E KL + H NI+A+R Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 127 DI-IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + P ++ + E + S + + + + QI RG+ Y+H + Sbjct: 75 GVCLKEP------NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 186 ---LHRDLKPSNLLLN--------ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +HRDLK SN+L+ +N LKI DFGLAR + M+ W APE+ Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM-APEV 187 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 + +S ++ DVWS G + EL+ + F G D Sbjct: 188 I-RASMFSKGSDVWSYGVLLWELLTGEVPFRGID 220 >3PFQ-A nrPDB Length = 674 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 103/226 (45%), Gaps = 28/226 (12%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +M +GKG++G V + T+E A+K L++ +++ D E + Sbjct: 346 LMVLGKGSFGKVMLSERKGTDELYAVK--------------ILKKDVVIQDDDVECTMVE 391 Query: 126 RDIIPPPLRNAF-NDVYIAYELMD-----------TDLHQIIRSNQALSEEHCQYFLYQI 173 + ++ P + F ++ ++ MD DL I+ E H ++ +I Sbjct: 392 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRAP 232 GL ++ S +++RDLK N++L++ +KI DFG+ + T+ + T Y AP Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 511 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 E++ Y ++D W+ G + E++ + F G D + +ME Sbjct: 512 EIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 556 >3ORP-A nrPDB Length = 311 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 83/173 (47%), Gaps = 21/173 (12%) Query: 106 RTLREIKLLRHMDHENIVAIRDII-------PPPLRNAFNDVYIAYELMD-TDLHQIIRS 157 R RE + ++H IVA+ D P P YI E +D L I+ + Sbjct: 58 RFRREAQNAAALNHPAIVAVYDTGEAETPAGPLP--------YIVMEYVDGVTLRDIVHT 109 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES 217 ++ + + + L + H ++HRD+KP+N++++A +K+ DFG+AR ++S Sbjct: 110 EGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADS 169 Query: 218 D---FMTEYVV-TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPG 266 T V+ T Y +PE S A DV+S+GC+ E++ +P F G Sbjct: 170 GNSVTQTAAVIGTAQYLSPEQARGDS-VDARSDVYSLGCVLYEVLTGEPPFTG 221 >3DTC-A nrPDB Length = 271 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 98/214 (45%), Gaps = 24/214 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAIR 126 IG G +G V A + VA+K + D I + +E KL + H NI+A+R Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 127 DI-IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + P ++ + E + S + + + + QI RG+ Y+H + Sbjct: 73 GVCLKEP------NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 186 ---LHRDLKPSNLLLN--------ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +HRDLK SN+L+ +N LKI DFGLAR + M+ W APE+ Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEV 185 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 + +S ++ DVWS G + EL+ + F G D Sbjct: 186 I-RASMFSKGSDVWSYGVLLWELLTGEVPFRGID 218 >4OLI-A nrPDB Length = 645 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 96/210 (45%), Gaps = 21/210 (10%) Query: 61 KYKPPIMPIGKGAYGIVC----SAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 +Y I +G+G +G V N T E VA+K + + + +EI +LR Sbjct: 353 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWK-QEIDILRT 411 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 + HE+I+ + + V + Y + + + R + L++ F QI G Sbjct: 412 LYHEHIIKYKGCCEDQGEKSLQLV-MEYVPLGSLRDYLPRHSIGLAQ--LLLFAQQICEG 468 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--------W 228 + Y+HS + +HR+L N+LL+ + +KI DFGLA+ E EY R W Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGDSPVFW 525 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 Y APE L Y A+ DVWS G EL+ Sbjct: 526 Y-APECLKEYKFYYAS-DVWSFGVTLYELL 553 >6F3F-A nrPDB Length = 455 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 97/207 (46%), Gaps = 19/207 (9%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 + +G+G +G V + T VAIK + + + L+E ++++ + HE +V + Sbjct: 193 VKLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLY 248 Query: 127 DIIPPPLRNAFNDVYIAYELMDT-DLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSA 183 ++ +YI E M+ L ++ + + L QI G+ Y+ Sbjct: 249 AVVSE------EPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM 302 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSD 240 N +HRDL+ +N+L+ N K+ DFGLAR+ ++++ +W APE L Sbjct: 303 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPEAALYGR- 360 Query: 241 YTAAIDVWSVGCIFMELMDRKPL-FPG 266 +T DVWS G + EL + + +PG Sbjct: 361 FTIKSDVWSFGILLTELTTKGRVPYPG 387 >4TPT-A nrPDB Length = 303 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 92/213 (43%), Gaps = 28/213 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG +G + T + + +K++ ++ K L E+K++R +DH N++ + Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRC--DEETQKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 + + YI L +RS + F I G+ Y+HS ++HR Sbjct: 66 LYKDKKLNLLTEYIE----GGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSE-------------------SDFMTEYVVTR-- 227 DL N L+ + + + DFGL+R+ E +D Y V Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR 260 ++ APE +LN Y +D++S G + E++ + Sbjct: 182 YWMAPE-MLNGKSYDETVDIFSFGIVLCEIIGQ 213 >5SYS-A nrPDB Length = 286 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 95/211 (45%), Gaps = 31/211 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G +G C VAIK + + + L+E ++++ + HE +V + + Sbjct: 26 LGQGCFG-ECWMGTWNGTTRVAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 81 Query: 129 IPPPLRNAFNDVYIAYELMDT---------DLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 + + +YI E M ++ + +R Q + QI G+ Y Sbjct: 82 V------SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD------MAAQIASGMAY 129 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLL 236 + N +HRDL+ +N+L+ N K+ DFGLAR+ ++++ +W APE L Sbjct: 130 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPEAAL 188 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPL-FPG 266 +T DVWS G + EL + + +PG Sbjct: 189 YGR-FTIKSDVWSFGILLTELTTKGRVPYPG 218 >3A4O-X nrPDB Length = 286 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 18/225 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V + + + VA+K + + + L E L++ + H+ +V + + Sbjct: 21 LGAGQFGEVWMGYYNNSTK-VAVKTLKPG---TMSVQAFLEEANLMKTLQHDKLVRLYAV 76 Query: 129 IPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYIHSANV 185 + +YI E M L ++S++ + F QI G+ YI N Sbjct: 77 VTRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 131 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDYT 242 +HRDL+ +N+L++ + KI DFGLARV ++++ +W APE +N +T Sbjct: 132 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKW-TAPE-AINFGCFT 189 Query: 243 AAIDVWSVGCIFMELMDRKPL-FPGRDHVHQLRLLMELIGTPSEE 286 DVWS G + E++ + +PGR + + L + P E Sbjct: 190 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 >3M42-A nrPDB Length = 299 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 118/304 (38%), Gaps = 59/304 (19%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHE 120 YK +G G G V N T E A+K + D + RE++L R Sbjct: 19 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCP 71 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGL 177 +IV I D+ L + I E +D +L I R +QA +E + I + Sbjct: 72 HIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------------------- 171 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 Y + D+WS+G I L+ P F H L + + + EF N Sbjct: 172 ---GEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN-- 223 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 P + S K LI +L +P +R+T+ + + HP++ + Sbjct: 224 --------PEWSEVSEEVKM---------LIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 266 Query: 355 SDEP 358 P Sbjct: 267 PQTP 270 >4EBW-A nrPDB Length = 304 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 77/277 (27%), Positives = 121/277 (43%), Gaps = 47/277 (16%) Query: 69 IGKGAYGIVCSA--MNSETNE-SVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG+G +G V M+ E +VAIK N + + K L+E +R DH +IV + Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK-FLQEALTMRQFDHPHIVKL 104 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSA 183 +I N V+I EL +L ++ + +L + YQ+ L Y+ S Sbjct: 105 IGVITE------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 158 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY---VVTRWYRAPELLLNSSD 240 +HRD+ N+L+++N +K+ DFGL+R +S + + +W APE +N Sbjct: 159 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APE-SINFRR 216 Query: 241 YTAAIDVWSVG-CIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 +T+A DVW G C++ LM F G + ++IG EN +R Sbjct: 217 FTSASDVWMFGVCMWEILMHGVKPFQGVKN-------NDVIGRI---------ENGERL- 259 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 P P P P L+ K +DP RR Sbjct: 260 ----PMP--------PNCPPTLYSLMTKCWAYDPSRR 284 >5HLW-A nrPDB Length = 299 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 92/202 (45%), Gaps = 16/202 (7%) Query: 69 IGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG+G +G V N A+K + N + + + L E +++ H N++++ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIMKDFSHPNVLSL 86 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSAN 184 I LR+ + + + + DL IR+ + + F Q+ +G+KY+ S Sbjct: 87 LGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK 143 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT------RWYRAPELLLNS 238 +HRDL N +L+ +K+ DFGLAR + ++ + + T +W L + Sbjct: 144 FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALES--LQT 201 Query: 239 SDYTAAIDVWSVGCIFMELMDR 260 +T DVWS G + ELM R Sbjct: 202 QKFTTKSDVWSFGVLLWELMTR 223 >2HW6-A nrPDB Length = 307 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 35/306 (11%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RHMDHE 120 YK +G+GAY V A++ + + A+K I + R RE++ L + ++ Sbjct: 14 YKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGH--SRSRVFREVETLYQCQGNK 71 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 NI+ + + R Y+ +E L + I+ + +E + + L + Sbjct: 72 NILELIEFFEDDTR-----FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 126 Query: 180 IHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVV--------TRW 228 +H+ + HRDLKP N+L + +KICDF L ++ T + Sbjct: 127 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 186 Query: 229 YRAPELLLNSSD----YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 Y APE++ +D Y D+WS+G + ++ P F G E+ Sbjct: 187 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 246 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 + E + E +Y + P I+ + A DLI K+L D ++R++ L Sbjct: 247 NKLFESIQEG--KY--EFPDKDWAHISSE-------AKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 345 HPYLNS 350 HP++ Sbjct: 296 HPWVQG 301 >4F9B-A nrPDB Length = 361 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 44/154 (28%), Positives = 72/154 (46%), Gaps = 31/154 (20%) Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC-DLKICDFGLARVTSESD 218 +LS + + ++ + + LK IH ++HRD+KPSN L N + DFGLA+ T ++ Sbjct: 113 SLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTK 172 Query: 219 F-MTEYVV----------------------------TRWYRAPELLLNSSDYTAAIDVWS 249 + ++V T +RAPE+L + T AID+WS Sbjct: 173 IELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWS 232 Query: 250 VGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGT 282 G IF+ L+ R P + D + L +M + G+ Sbjct: 233 AGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS 266 >6NPU-A nrPDB Length = 298 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 102/209 (48%), Gaps = 25/209 (11%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++T K+K +G G YG V + + + +VA+K + ++ ++ + L+E +++ Sbjct: 27 DITMKHK-----LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKE 78 Query: 117 MDHENIVAIRDIIP--PPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFLY 171 + H N+V + + PP YI E M +L +R + Q ++ Y Sbjct: 79 IKHPNLVQLLGVCTREPPF-------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 131 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 QI ++Y+ N +HRDL N L+ N +K+ DFGL+R+ + D T + ++ Sbjct: 132 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIK 190 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L + ++ DVW+ G + E+ Sbjct: 191 WTAPESLAYNK-FSIKSDVWAFGVLLWEI 218 >3KUL-B nrPDB Length = 325 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 92/200 (46%), Gaps = 18/200 (9%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG G G VC + + + VAIK + + + + L E ++ DH NI+ + Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTER-QRRDFLSEASIMGQFDHPNIIRL 115 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSAN 184 ++ R + Y + + L +R++ + L + G++Y+ Sbjct: 116 EGVVT---RGRLAMIVTEY-MENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLG 171 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT------RWYRAPELLLNS 238 +HRDL N+L+++N K+ DFGL+RV E D Y T RW APE + Sbjct: 172 YVHRDLAARNVLVDSNLVCKVSDFGLSRVL-EDDPDAAYTTTGGKIPIRWT-APEAIAFR 229 Query: 239 SDYTAAIDVWSVGCIFMELM 258 + +++A DVWS G + E++ Sbjct: 230 T-FSSASDVWSFGVVMWEVL 248 >4XEY-B nrPDB Length = 408 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 102/209 (48%), Gaps = 25/209 (11%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++T K+K +G G YG V + + + +VA+K + ++ ++ + L+E +++ Sbjct: 126 DITMKHK-----LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKE 177 Query: 117 MDHENIVAIRDIIP--PPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFLY 171 + H N+V + + PP YI E M +L +R + Q ++ Y Sbjct: 178 IKHPNLVQLLGVCTREPPF-------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 230 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 QI ++Y+ N +HRDL N L+ N +K+ DFGL+R+ + D T + ++ Sbjct: 231 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIK 289 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L + ++ DVW+ G + E+ Sbjct: 290 WTAPESLA-YNKFSIKSDVWAFGVLLWEI 317 >4XCU-A nrPDB Length = 300 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 96/209 (45%), Gaps = 26/209 (12%) Query: 68 PIGKGAYGIVCSA-------MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-H 119 P+G+G +G V A + +VA+K + + +K D + E+++++ + H Sbjct: 24 PLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK-DLADLVSEMEVMKLIGRH 82 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIR-------SNQALSEEHCQYFLY 171 +NI+ + + +Y+ E +L + +R S LS Y Sbjct: 83 KNIINLLGVC-----TQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAY 137 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 Q+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D+ + R Sbjct: 138 QVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVK 197 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L + YT DVWS G + E+ Sbjct: 198 WMAPEALFDRV-YTHQSDVWSFGILLWEI 225 >4AT3-A nrPDB Length = 299 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 101/212 (47%), Gaps = 32/212 (15%) Query: 69 IGKGAYGIV----CSAMNSETNES-VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 +G+GA+G V C + E ++ VA+K + +A DN K RE +LL ++ HE+IV Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA--RKDFHREAELLTNLQHEHIV 78 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN-------------QALSEEHCQYF 169 + + + + +E M DL++ +R++ L++ + Sbjct: 79 KFYGVCVEG-----DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHI 133 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT----EYVV 225 QI G+ Y+ S + +HRDL N L+ N +KI DFG++R +D+ + Sbjct: 134 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 193 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 RW PE ++ +T DVWS+G + E+ Sbjct: 194 IRWM-PPESIM-YRKFTTESDVWSLGVVLWEI 223 >3C1X-A nrPDB Length = 373 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 92/202 (45%), Gaps = 16/202 (7%) Query: 69 IGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG+G +G V N A+K + N + + + L E +++ H N++++ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIMKDFSHPNVLSL 155 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSAN 184 I LR+ + + + + DL IR+ + + F Q+ +G+K++ S Sbjct: 156 LGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKK 212 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT------RWYRAPELLLNS 238 +HRDL N +L+ +K+ DFGLAR + +F + + T +W L + Sbjct: 213 FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALES--LQT 270 Query: 239 SDYTAAIDVWSVGCIFMELMDR 260 +T DVWS G + ELM R Sbjct: 271 QKFTTKSDVWSFGVLLWELMTR 292 >6J5U-C nrPDB Length = 426 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 94/211 (44%), Gaps = 27/211 (12%) Query: 69 IGKGAYGIVCSAMNSETNES---------VAIKKIA-NAFDNKIDAKRTLREIKLLRHMD 118 +G+G +G V +T+ + VA+K++ F K L E+ L + Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGH---KEWLTEVNYLGQLS 148 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM---DTDLHQIIRSNQALSEEHCQYFLYQILR 175 H N+V + + + YE M + H R Q L+ + Sbjct: 149 HPNLVLLVGYCAEG-----ENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAK 203 Query: 176 GLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTRWYR 230 GL ++H A V++RD K +N+LL+A+ + K+ DFGLA+ D T+ + T Y Sbjct: 204 GLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYA 263 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRK 261 APE + + TA DV+S G + +EL+ + Sbjct: 264 APEYVA-TGRLTAKSDVYSFGVVLLELISGR 293 >2XYN-A nrPDB Length = 292 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 104/209 (49%), Gaps = 25/209 (11%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++T K+K +G G YG V + + + +VA+K + ++ ++ + L+E +++ Sbjct: 33 DITMKHK-----LGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKE 84 Query: 117 MDHENIVAIRDI--IPPPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFLY 171 + H N+V + + + PP YI E M +L +R + + ++ Y Sbjct: 85 IKHPNLVQLLGVCTLEPPF-------YIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 QI ++Y+ N +HRDL N L+ N +K+ DFGL+R+ + D T + ++ Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIK 196 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L ++ ++ DVW+ G + E+ Sbjct: 197 WTAPESLAYNT-FSIKSDVWAFGVLLWEI 224 >4UYA-A nrPDB Length = 340 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 20/212 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G +G V A +V + D A+ RE +L + H NI+ +R + Sbjct: 34 IGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGV 93 Query: 129 -IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN--- 184 + P + + E + + + + QI RG+ Y+H Sbjct: 94 CLQQP------HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHEEAFVP 147 Query: 185 VLHRDLKPSNLLL--------NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 +LHRDLK SN+LL N LKI DFGLAR + M W APE ++ Sbjct: 148 ILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM-APE-VI 205 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 SS ++ D+WS G + EL+ + + G D Sbjct: 206 KSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >2J0K-A nrPDB Length = 656 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/277 (27%), Positives = 120/277 (43%), Gaps = 47/277 (16%) Query: 69 IGKGAYGIVCSA--MNSET-NESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IG+G +G V M+ E +VAIK N + + K L+E +R DH +IV + Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREK-FLQEALTMRQFDHPHIVKL 456 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSA 183 +I N V+I EL +L ++ + +L + YQ+ L Y+ S Sbjct: 457 IGVITE------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESK 510 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE---YVVTRWYRAPELLLNSSD 240 +HRD+ N+L++A +K+ DFGL+R +S + + +W APE +N Sbjct: 511 RFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APE-SINFRR 568 Query: 241 YTAAIDVWSVG-CIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 +T+A DVW G C++ LM F G + ++IG EN +R Sbjct: 569 FTSASDVWMFGVCMWEILMHGVKPFQGVKN-------NDVIGRI---------ENGERL- 611 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 P P P P L+ K +DP RR Sbjct: 612 ----PMP--------PNCPPTLYSLMTKCWAYDPSRR 636 >1TKI-A nrPDB Length = 321 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 126/285 (44%), Gaps = 39/285 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G +GIV + + + ++ K + +++ K+ EI +L H NI+ + + Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIARHRNILHLHES 69 Query: 129 IPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANVL 186 + ++ + +E + D+ + I ++ L+E +++Q+ L+++HS N+ Sbjct: 70 FE-----SMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIG 124 Query: 187 HRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 H D++P N++ + +KI +FG AR D Y APE+ + TA Sbjct: 125 HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTAT 184 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 D+WS+G + L+ + P FL E ++ I + Sbjct: 185 -DMWSLGTLVYVLLS--GINP------------------------FLAETNQQIIENIMN 217 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + F + A+D ++++L + + R+T +AL HP+L Sbjct: 218 AEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLK 262 >3BEA-A nrPDB Length = 333 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 23/210 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI---DAKRTL-REIKLLRHM-DHENIV 123 +G GA+G V A + A+ K+A D K L E+K++ H+ HENIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 124 AIRDIIP---PPL--------RNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 + P L + N + +++TD I +N LS +F Q Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAI-ANSTLSTRDLLHFSSQ 172 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---YVVTRW 228 + +G+ ++ S N +HRD+ N+LL KI DFGLAR + ++S+++ + + +W Sbjct: 173 VAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW 232 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 APE + + YT DVWS G + E+ Sbjct: 233 -MAPESIFDCV-YTVQSDVWSYGILLWEIF 260 >2FO0-A nrPDB Length = 495 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 102/209 (48%), Gaps = 25/209 (11%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++T K+K +G G YG V + + + +VA+K + ++ ++ + L+E +++ Sbjct: 218 DITMKHK-----LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKE 269 Query: 117 MDHENIVAIRDIIP--PPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFLY 171 + H N+V + + PP YI E M +L +R + Q ++ Y Sbjct: 270 IKHPNLVQLLGVCTREPPF-------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 322 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 QI ++Y+ N +HR+L N L+ N +K+ DFGL+R+ + D T + ++ Sbjct: 323 QISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIK 381 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L + ++ DVW+ G + E+ Sbjct: 382 WTAPESLA-YNKFSIKSDVWAFGVLLWEI 409 >5UIU-A nrPDB Length = 323 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 95/203 (46%), Gaps = 18/203 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIR 126 +G+G +G+V + N +VA+KK+A D + + +EIK++ HEN+V + Sbjct: 55 MGEGGFGVVYKGYVN--NTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 127 DIIPPPLRNAFNDVYIAYELMDT----DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + +D+ + Y M D + LS G+ ++H Sbjct: 113 -----GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 167 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE--SDFMTEYVV-TRWYRAPELLLNSS 239 + +HRD+K +N+LL+ KI DFGLAR + + MT +V T Y APE L Sbjct: 168 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RG 225 Query: 240 DYTAAIDVWSVGCIFMELMDRKP 262 + T D++S G + +E++ P Sbjct: 226 EITPKSDIYSFGVVLLEIITGLP 248 >4AW2-A nrPDB Length = 437 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 114/258 (44%), Gaps = 43/258 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA+G VA+ K+ NA +K+ A + L + ++L+ + RD+ Sbjct: 82 IGRGAFG------------EVAVVKLKNA--DKVFAMKILNKWEMLKRAETACFREERDV 127 Query: 129 IP-------PPLRNAFNDVYIAYELMD----TDLHQII-RSNQALSEEHCQYFLYQILRG 176 + L AF D Y +MD DL ++ + L EE +++L +++ Sbjct: 128 LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPEL 234 + +H + +HRD+KP N+L++ N +++ DFG E + V T Y +PE+ Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 235 LL----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 L Y D WS+G E++ + F V +M +E +F Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-----HKERFQF 302 Query: 291 ------LNENAKRYIRQL 302 ++ENAK IR+L Sbjct: 303 PTQVTDVSENAKDLIRRL 320 >6ED6-A nrPDB Length = 415 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 95/206 (46%), Gaps = 31/206 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA+G ++ + + K+ A + L + ++++ D RDI Sbjct: 96 IGRGAFG--------------EVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI 141 Query: 129 IP-------PPLRNAFND---VYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 + L AF D +Y+ E M DL ++ SN + E+ +++ +++ L Sbjct: 142 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM-SNYDVPEKWAKFYTAEVVLAL 200 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM--TEYVVTRWYRAPELL 235 IHS ++HRD+KP N+LL+ + LK+ DFG E+ + V T Y +PE+L Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 260 Query: 236 LNSSD---YTAAIDVWSVGCIFMELM 258 + Y D WSVG E++ Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEML 286 >6GVJ-A nrPDB Length = 429 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 128/295 (43%), Gaps = 49/295 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG G V +N E + AIK + A + +D+ R EI L + + IR Sbjct: 152 IGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRN--EIAYLNKLQQHSDKIIR 208 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + + + + +Y+ E + DL+ ++ +++ + + +L + IH ++ Sbjct: 209 -LYDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 265 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSSD--- 240 H DLKP+N L+ + LK+ DFG+A + + S V T Y PE + + S Sbjct: 266 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRE 324 Query: 241 -------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 + DVWS+GCI + K P + ++Q+ L +I E+EF Sbjct: 325 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIID--PNHEIEF--- 377 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P P + + D+++ L DP++RI++ + LAHPY+ Sbjct: 378 ---------PDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYV 412 >2PL0-A nrPDB Length = 289 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 93/206 (45%), Gaps = 21/206 (10%) Query: 69 IGKGAYGIVCSAM-NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G G +G V N T VA+K + + L E L++ + H+ +V + Sbjct: 31 LGAGQFGEVWMGYYNGHTK--VAVKSLKQG---SMSPDAFLAEANLMKQLQHQRLVRLYA 85 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSAN 184 ++ +YI E M+ L ++ S L+ QI G+ +I N Sbjct: 86 VVTQ------EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDY 241 +HRDL+ +N+L++ KI DFGLAR+ ++++ +W APE +N + Sbjct: 140 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW-TAPE-AINYGTF 197 Query: 242 TAAIDVWSVGCIFMELMDRKPL-FPG 266 T DVWS G + E++ + +PG Sbjct: 198 TIKSDVWSFGILLTEIVTHGRIPYPG 223 >3G0E-A nrPDB Length = 336 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 37/95 (38%), Positives = 54/95 (56%), Gaps = 6/95 (6%) Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---YV 224 F YQ+ +G+ ++ S N +HRDL N+LL KICDFGLAR + ++S+++ + + Sbjct: 173 FSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARL 232 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 +W APE + N YT DVWS G EL Sbjct: 233 PVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFS 265 >4K33-A nrPDB Length = 325 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 103/217 (47%), Gaps = 33/217 (15%) Query: 68 PIGKGAYG--IVCSAMNSETNE-----SVAIKKIANAFDNKIDAKRTLREIKLLRHM-DH 119 P+G+GA+G ++ A+ + + +VA+K + + +K D + E+++++ + H Sbjct: 43 PLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK-DLSDLVSEMEMMKMIGKH 101 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN----------------QALSE 163 +NI+ +++ + V + Y +L + +R+ + L+ Sbjct: 102 KNII---NLLGACTQGGPLYVLVEYA-AKGNLREFLRARRPPGLDYSFDTSKPPEEQLTF 157 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D+ E Sbjct: 158 KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKET 217 Query: 224 VVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 R + APE L + YT DVWS G + E+ Sbjct: 218 TNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLWEI 253 >6FER-A nrPDB Length = 309 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 86/194 (44%), Gaps = 25/194 (12%) Query: 80 AMNSETNESVAIK-KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD--IIPPPLRNA 136 A++ N+ V + K+ A NK L+EIK++ + NI+ + I PL Sbjct: 42 ALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPL--- 98 Query: 137 FNDVYIAYELMDTDLHQIIRSNQ----------ALSEEHCQYFLYQILRGLKYIHSANVL 186 I + + DL+Q + ++ +S + ++ QI G+KY+ S N + Sbjct: 99 ---CMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFV 155 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFM----TEYVVTRWYRAPELLLNSSDYT 242 HRDL N L+ N +KI DFG++R D+ + RW +LL +T Sbjct: 156 HRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGK--FT 213 Query: 243 AAIDVWSVGCIFME 256 A DVW+ G E Sbjct: 214 TASDVWAFGVTLWE 227 >5AP3-A nrPDB Length = 313 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 74/314 (23%), Positives = 133/314 (42%), Gaps = 49/314 (15%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAKRT 107 N++ V + + IG G V +N E + AIK + A + +D+ R Sbjct: 17 NLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRN 75 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ 167 EI L + + IR + + + + +Y+ E + DL+ ++ +++ + Sbjct: 76 --EIAYLNKLQQHSDKIIR-LYDYEITDQY--IYMVMECGNIDLNGWLKKKKSIDPWERK 130 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT---SESDFMTEYV 224 + +L + IH ++H DLKP+N L+ + LK+ DFG+A + S V Sbjct: 131 SYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQV 189 Query: 225 VTRWYRAPELLLNSSD----------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 T Y PE + + S + DVWS+GCI + K P + ++Q+ Sbjct: 190 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQIS 247 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 L +I E+EF P P + + D+++ L DP+ Sbjct: 248 KLHAIID--PNHEIEF------------PDIPEKDLQ-----------DVLKCCLKRDPK 282 Query: 335 RRITVLDALAHPYL 348 +RI++ + LAHPY+ Sbjct: 283 QRISIPELLAHPYV 296 >6BXI-A nrPDB Length = 333 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 98/243 (40%), Gaps = 62/243 (25%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA+G V +T A+K LR+ +L +I A RDI Sbjct: 14 IGRGAFGEVRLVQKKDTGHVYAMK--------------ILRKADMLEKEQVGHIRAERDI 59 Query: 129 IPP-------PLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGL 177 + + +F D Y +M+ D+ ++ L+EE Q+++ + + + Sbjct: 60 LVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---------------SDFMTE 222 IH +HRD+KP NLLL++ +K+ DFGL + SDF + Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 223 YVVTR-----WYR----------------APELLLNSSDYTAAIDVWSVGCIFMELMDRK 261 + ++ W R APE+ + + Y D WS+G I E++ Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGY 238 Query: 262 PLF 264 P F Sbjct: 239 PPF 241 >3TXO-A nrPDB Length = 353 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 94/198 (47%), Gaps = 12/198 (6%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAF---DNKIDAKRTLREIKLLRHMDHENI 122 I +GKG++G V A ET + A+K + D+ ++ T + I L +H + Sbjct: 28 IRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR-NHPFL 86 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 + P R ++ E ++ DL I+ ++ E +++ +I+ L ++H Sbjct: 87 TQLFCCFQTPDR-----LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 141 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSD 240 +++RDLK N+LL+ K+ DFG+ + + T + T Y APE +L Sbjct: 142 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE-ILQEML 200 Query: 241 YTAAIDVWSVGCIFMELM 258 Y A+D W++G + E++ Sbjct: 201 YGPAVDWWAMGVLLYEML 218 >5LPZ-A nrPDB Length = 332 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 101/216 (46%), Gaps = 11/216 (5%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 F ++ + T + + IG G +G V A+ + +VAIKK+ + + + E+ Sbjct: 9 FADLLQATNGFHNDSL-IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQ--GDREFMAEM 64 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLY 171 + + + H N+V + ++ Y ++ LH ++ L+ + Sbjct: 65 ETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 172 QILRGLKYIH---SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTEYVV 225 RGL ++H S +++HRD+K SN+LL+ N + ++ DFG+AR+ S D ++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG 184 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK 261 T Y PE S + DV+S G + +EL+ K Sbjct: 185 TPGYVPPE-YYQSFRCSTKGDVYSYGVVLLELLTGK 219 >2PSQ-A nrPDB Length = 370 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 35/90 (38%), Positives = 50/90 (55%), Gaps = 4/90 (4%) Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 YQ+ RG++Y+ S +HRDL N+L+ N +KI DFGLAR + D+ + R Sbjct: 210 YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 269 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE L + YT DVWS G + E+ Sbjct: 270 KWMAPEALFDRV-YTHQSDVWSFGVLMWEI 298 >5LPV-A nrPDB Length = 296 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 101/216 (46%), Gaps = 11/216 (5%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 F ++ + T + + IG G +G V A+ + +VAIKK+ + + + E+ Sbjct: 9 FADLLQATNGFHNDSL-IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQ--GDREFMAEM 64 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLY 171 + + + H N+V + ++ Y ++ LH ++ L+ + Sbjct: 65 ETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 172 QILRGLKYIH---SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTEYVV 225 RGL ++H S +++HRD+K SN+LL+ N + ++ DFG+AR+ S D ++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG 184 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK 261 T Y PE S + DV+S G + +EL+ K Sbjct: 185 TPGYVPPE-YYQSFRCSTKGDVYSYGVVLLELLTGK 219 >5XD6-A nrPDB Length = 305 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 103/213 (48%), Gaps = 29/213 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD- 127 IG+G+YG V + ++ ++ AIKK+ ++ K + L ++ ++ + EN+VA+ Sbjct: 30 IGEGSYGRVFYGI-LKSGKAAAIKKLDSS---KQPDQEFLAQVSMVSRLRQENVVALLGY 85 Query: 128 IIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA---------LSEEHCQYFLYQILRGL 177 + PLR +AYE + LH I+ + LS RGL Sbjct: 86 CVDGPLR------VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGL 139 Query: 178 KYIHSA---NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTRWYRA 231 +Y+H +V+HRD+K SN+LL + KI DF L+ + T + T Y A Sbjct: 140 EYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHA 199 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELM-DRKPL 263 PE + + T + DV+S G + +EL+ RKP+ Sbjct: 200 PEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPV 231 >3HMP-A nrPDB Length = 342 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 128/295 (43%), Gaps = 49/295 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG G V +N E + AIK + A + +D+ R EI L + + IR Sbjct: 64 IGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRN--EIAYLNKLQQHSDKIIR 120 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + + + + +Y+ E + DL+ ++ +++ + + +L + IH ++ Sbjct: 121 -LYDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSSD--- 240 H DLKP+N L+ + LK+ DFG+A + + S V T Y PE + + S Sbjct: 178 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRE 236 Query: 241 -------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 + DVWS+GCI + K P + ++Q+ L +I E+EF Sbjct: 237 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIID--PNHEIEF--- 289 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P P + + D+++ L DP++RI++ + LAHPY+ Sbjct: 290 ---------PDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYV 324 >4C59-A nrPDB Length = 340 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 76/330 (23%), Positives = 137/330 (41%), Gaps = 34/330 (10%) Query: 35 NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI 94 ++P +L Q + G E+ + +G + V A + + A+K++ Sbjct: 1 SMPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 60 Query: 95 ANAFDNKIDAKRTLREIKLLRHMD-HENIV---AIRDIIPPPLRNAFNDVYIAYELMDTD 150 + + K A ++E+ ++ + H NIV + I + + EL Sbjct: 61 LSNEEEKNRA--IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQ 118 Query: 151 LHQIIRSNQALSEEHCQYFL---YQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKI 205 L + ++ ++ C L YQ R ++++H ++HRDLK NLLL+ +K+ Sbjct: 119 LVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKL 178 Query: 206 CDFGLARVTS---------ESDFMTEYVVTR----WYRAPELLLNSSDYTAA--IDVWSV 250 CDFG A S + + E +TR YR PE++ S++ D+W++ Sbjct: 179 CDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWAL 238 Query: 251 GCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSI 310 GCI L R+ F + +LR++ P + + + R + Q+ P R SI Sbjct: 239 GCILYLLCFRQHPF---EDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSI 295 Query: 311 TDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 + VH L I +P+ IT L Sbjct: 296 AE---VVHQL--QEIAAARNVNPKSPITEL 320 >3V5Q-A nrPDB Length = 297 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 106/225 (47%), Gaps = 39/225 (17%) Query: 69 IGKGAYGIV----CSAMNSETNES-VAIKKIANAFDNKIDAKRTL-REIKLLRHMDHENI 122 +G+GA+G V C ++ ++ VA+K + D + A++ RE +LL ++ HE+I Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALK---DPTLAARKDFQREAELLTNLQHEHI 79 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN-------------QALSEEHCQY 168 V + + + + +E M DL++ +R++ QA E Sbjct: 80 VKFYGVCGDG-----DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQ 134 Query: 169 FLY---QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT---- 221 L+ QI G+ Y+ S + +HRDL N L+ AN +KI DFG++R +D+ Sbjct: 135 MLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGH 194 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM--DRKPLF 264 + RW PE ++ +T DVWS G I E+ ++P F Sbjct: 195 TMLPIRWM-PPESIMYRK-FTTESDVWSFGVILWEIFTYGKQPWF 237 >3VHK-A nrPDB Length = 368 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 6/102 (5%) Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDF 219 L+ EH + +Q+ +G++++ S +HRDL N+LL+ +KICDFGLAR + + D+ Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 220 MTE---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + + + +W APE + + YT DVWS G + E+ Sbjct: 257 VRKGDARLPLKWM-APETIFDRV-YTIQSDVWSFGVLLWEIF 296 >5HI2-A nrPDB Length = 283 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 116/258 (44%), Gaps = 29/258 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 IG G++G V + + VA+K + AF N++ R R + +L M + Sbjct: 28 IGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYST--- 81 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 P L + + + H + S + Q RG+ Y+H+ + Sbjct: 82 -----KPQL-----AIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKS 131 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRWYRAPEL--LLNSS 239 ++HRDLK +N+ L+ + +KI DFGLA V S S + + + APE+ + +S+ Sbjct: 132 IIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSN 191 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS-EEELEFLNENAKRY 298 Y+ DV++ G + ELM + + ++ Q ++E++G S +L + N + Sbjct: 192 PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVGRGSLSPDLSKVRSNCPKR 248 Query: 299 IRQLPPYPRQSITDKFPT 316 +++L + D+ P+ Sbjct: 249 MKRLMAECLKKKRDERPS 266 >6E9W-A nrPDB Length = 443 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 94/206 (45%), Gaps = 31/206 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+GA+G V + T K+ A + L + ++++ D RDI Sbjct: 110 IGRGAFGEVQLVRHKSTR--------------KVYAMKLLSKFEMIKRSDSAFFWEERDI 155 Query: 129 IP-------PPLRNAFND---VYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 + L AF D +Y+ E M DL ++ SN + E+ +++ +++ L Sbjct: 156 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM-SNYDVPEKWARFYTAEVVLAL 214 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVV-TRWYRAPELL 235 IHS +HRD+KP N+LL+ + LK+ DFG ++ E + V T Y +PE+L Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 236 LNSSD---YTAAIDVWSVGCIFMELM 258 + Y D WSVG E++ Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEML 300 >4H1J-A nrPDB Length = 293 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 96/206 (46%), Gaps = 19/206 (9%) Query: 69 IGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 +G+G +G V + + N +V K DNK ++ + E +++++DH +IV Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK---EKFMSEAVIMKNLDHPHIV 88 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + II ++Y EL H + R+ +L + QI + + Y+ S Sbjct: 89 KLIGIIEEEPTWIIMELYPYGELG----HYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV---TRWYRAPELLLNSSD 240 N +HRD+ N+L+ + +K+ DFGL+R + D+ V +W +PE +N Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKW-MSPE-SINFRR 202 Query: 241 YTAAIDVWSVGCIFMELMD--RKPLF 264 +T A DVW E++ ++P F Sbjct: 203 FTTASDVWMFAVCMWEILSFGKQPFF 228 >5U6B-A nrPDB Length = 307 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 95/219 (43%), Gaps = 29/219 (13%) Query: 69 IGKGAYGIVCSAMNSETNE--SVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI- 125 +G+G +G V ++ + VA+K + A + + + L E ++ DH N++ + Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 126 --------RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA------LSEEHCQYFLY 171 R+ P P V I + DLH + ++ L + F+ Sbjct: 91 GVCFQGSERESFPAP-------VVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMA 143 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 I G++Y+ + +HRDL N +LN N + + DFGL++ D+ + + + Sbjct: 144 DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK 203 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL-FPG 266 + A E L + YT+ DVWS G E+ R +PG Sbjct: 204 WIAIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPG 241 >3GQL-A nrPDB Length = 326 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 102/220 (46%), Gaps = 39/220 (17%) Query: 68 PIGKGAYG--IVCSAMNSETNE-----SVAIKKIANAFDNKIDAKRTLREIKLLRHM-DH 119 P+G+GA+G ++ A+ + ++ VA+K + + K D + E+++++ + H Sbjct: 35 PLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK-DLSDLISEMEMMKMIGKH 93 Query: 120 ENIVAIRDIIPPPLRNAFND--VYIAYELMDT-DLHQIIRSNQALSEEHCQ--------- 167 +NI+ + L D +Y+ E +L + +++ + E+C Sbjct: 94 KNIINL-------LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 146 Query: 168 -------YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D+ Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 221 TEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + R + APE L + YT DVWS G + E+ Sbjct: 207 KKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEI 245 >3TT0-A nrPDB Length = 382 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 53/102 (51%), Gaps = 4/102 (3%) Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 + LS + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D Sbjct: 186 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 245 Query: 219 FMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + + R + APE L + YT DVWS G + E+ Sbjct: 246 YYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEI 286 >3QUP-A nrPDB Length = 323 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 92/214 (42%), Gaps = 31/214 (14%) Query: 69 IGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +GKG +G V A + + S VA+K + D + LRE ++ DH ++ + Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 90 Query: 126 RDI---------IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA------LSEEHCQYFL 170 + +P P+ V + + + DLH + +++ L + F+ Sbjct: 91 VGVSLRSRAKGRLPIPM------VILPF-MKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---- 226 I G++Y+ S N +HRDL N +L + + + DFGL+R D+ + + Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPV 203 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR 260 +W L N YT DVW+ G E+M R Sbjct: 204 KWLALESLADNL--YTVHSDVWAFGVTMWEIMTR 235 >2ZMD-A nrPDB Length = 390 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 127/295 (43%), Gaps = 49/295 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IG G V +N E + AIK + A + +D+ R EI L + + IR Sbjct: 64 IGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRN--EIAYLNKLQQHSDKIIR 120 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + + + + +Y+ E + DL+ ++ +++ + + +L + IH ++ Sbjct: 121 -LYDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSSD--- 240 H DLKP+N L+ + LK+ DFG+A + + S V Y PE + + S Sbjct: 178 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRE 236 Query: 241 -------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 + DVWS+GCI + K P + ++Q+ L +I E+EF Sbjct: 237 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII--DPNHEIEF--- 289 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P P + + D+++ L DP++RI++ + LAHPY+ Sbjct: 290 ---------PDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYV 324 >3KRL-A nrPDB Length = 335 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 93/216 (43%), Gaps = 31/216 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI---DAKRTL-REIKLLRHM-DHENIV 123 +G GA+G V A + A+ K+A D K L E+K++ H+ HENIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN----------------QALSEEHCQ 167 + Y Y DL +R + LS Sbjct: 114 NLLGACTHGGPVLVITEYCCY----GDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLL 169 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---Y 223 +F Q+ +G+ ++ S N +HRD+ N+LL KI DFGLAR + ++S+++ + Sbjct: 170 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 229 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 + +W APE + + YT DVWS G + E+ Sbjct: 230 LPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 263 >5A46-A nrPDB Length = 386 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 53/102 (51%), Gaps = 4/102 (3%) Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 + LS + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D Sbjct: 157 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 216 Query: 219 FMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + + R + APE L + YT DVWS G + E+ Sbjct: 217 YYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEI 257 >3HNG-A nrPDB Length = 360 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 33/93 (35%), Positives = 55/93 (59%), Gaps = 6/93 (6%) Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---YV 224 + +Q+ RG++++ S +HRDL N+LL+ N +KICDFGLAR + D++ + + Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRL 263 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 +W APE + + Y+ DVWS G + E+ Sbjct: 264 PLKWM-APESIFDKI-YSTKSDVWSYGVLLWEI 294 >4RT7-A nrPDB Length = 415 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 34/94 (36%), Positives = 54/94 (57%), Gaps = 6/94 (6%) Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---YV 224 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + S+S+++ + Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 +W APE L YT DVWS G + E+ Sbjct: 308 PVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 339 >4YFF-A nrPDB Length = 311 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 93/196 (47%), Gaps = 11/196 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVA-IR 126 IG G++G V N+ VAIK+ AN + +K D RE+ +L ++H ++ + Sbjct: 50 IGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 107 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN-- 184 + P + A YI+ + + LH+ + L + + +G++Y+H+ Sbjct: 108 ACLNDPSQFAIVTQYISGGSLFSLLHE---QKRILDLQSKLIIAVDVAKGMEYLHNLTQP 164 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARV--TSESDFMTEYVVTRWYRAPELLLNSSDYT 242 ++HRDL N+LL + + DFG +R + + D MT+ + APE+ + YT Sbjct: 165 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYT 224 Query: 243 AAIDVWSVGCIFMELM 258 DV+S E++ Sbjct: 225 IKADVFSYALCLWEIL 240 >3TKU-A nrPDB Length = 433 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 99/218 (45%), Gaps = 33/218 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG+GA+G VA+ K+ N +I A + L + ++L+ + Sbjct: 95 IKVIGRGAFG------------EVAVVKMKNT--ERIYAMKILNKWEMLKRAETACFREE 140 Query: 126 RDIIP-------PPLRNAFNDVYIAYELMD----TDLHQII-RSNQALSEEHCQYFLYQI 173 RD++ L AF D Y +MD DL ++ + L E+ ++++ ++ Sbjct: 141 RDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEM 200 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRA 231 + + IH + +HRD+KP N+LL+ N +++ DFG ++ + V T Y + Sbjct: 201 VLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYIS 260 Query: 232 PELLLNSSD----YTAAIDVWSVG-CIFMELMDRKPLF 264 PE+L D Y D WS+G C++ L P + Sbjct: 261 PEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY 298 >5TOS-A nrPDB Length = 395 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 102/242 (42%), Gaps = 54/242 (22%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE---------TNESVAIKKI-ANAFDNK 101 F + T ++P + IG+G +G V E T +A+KK+ F Sbjct: 57 FNELKLATRNFRPDSV-IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 Query: 102 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD----------- 150 + L EI L + H N+V +I L + + YE M Sbjct: 116 ---REWLTEINYLGQLSHPNLV---KLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGA 167 Query: 151 ----LHQIIRSNQALSEEHCQYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLNANCDLK 204 L +R N AL +GL ++HS V++RD+K SN+LL+A+ + K Sbjct: 168 YFKPLPWFLRVNVALDAA----------KGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 Query: 205 ICDFGLARVTSESDFMTEYVVTR-----WYRAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 + DFGLAR D YV TR Y APE ++S A DV+S G + +E++ Sbjct: 218 LSDFGLARDGPMGDL--SYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILS 274 Query: 260 RK 261 K Sbjct: 275 GK 276 >2OGV-A nrPDB Length = 317 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 98/208 (47%), Gaps = 23/208 (11%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI---DAKRTL-REIKLLRHM-DHENIV 123 +G GA+G V A + A+ K+A D K L E+K++ H+ HENIV Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 105 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQ--------YFLYQIL 174 +++ V Y L+ + R +A L +E + +F Q+ Sbjct: 106 ---NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVA 162 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTE---YVVTRWYR 230 +G+ ++ S N +HRD+ N+LL KI DFGLAR + ++S+++ + + +W Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-M 221 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELM 258 APE + + YT DVWS G + E+ Sbjct: 222 APESIFDCV-YTVQSDVWSYGILLWEIF 248 >2OZO-A nrPDB Length = 613 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK-KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + + + + K+ K D + +RE +++ +D+ IV + Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQ-IIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + + E+ LH+ ++ + + + L+Q+ G+KY+ N Sbjct: 404 VC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRW---YRAPELLLNSSDY 241 +HR+L N+LL KI DFGL++ D + T +W + APE +N + Sbjct: 458 VHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 516 Query: 242 TAAIDVWSVGCIFMELM 258 ++ DVWS G E + Sbjct: 517 SSRSDVWSYGVTMWEAL 533 >2H34-A nrPDB Length = 309 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 10/202 (4%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNK-IDAKRTLREIKLLRHMDHENIVAIRD 127 +G+G G V A ++ VA+K ++ + + R RE + + ++V I D Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 +Y+ L++ DL ++R L+ + QI L H+A Sbjct: 102 -----FGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGAT 156 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTEYVVTRWYRAPELLLNSSDYTAA 244 HRD+KP N+L++A+ + DFG+A T++ + V T +Y APE + S T Sbjct: 157 HRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFSESHATYR 215 Query: 245 IDVWSVGCIFMELMDRKPLFPG 266 D++++ C+ E + P + G Sbjct: 216 ADIYALTCVLYECLTGSPPYQG 237 >4CRS-A nrPDB Length = 341 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 124/294 (42%), Gaps = 56/294 (19%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANA-------FDNKIDAKRTLREIKLLRHMDHENIV 123 +G +G V A TNE AIK + D+ + KR + +RH N+ Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 A + + ++ DL I ++ SE ++ ++ GL+Y+H Sbjct: 82 AC-------FQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEH 133 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 +++RDLK NLLL+ +KI DFGL + D + + T + APE+L +S YT Sbjct: 134 KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS-YT 192 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL--EFLNENAKRYIR 300 A+D W +G + E++ + FPG D EEE+ +N+ + Sbjct: 193 RAVDWWGLGVLIYEMLVGESPFPGDD----------------EEEVFDSIVNDEVR---- 232 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-----DALAHPYLN 349 YPR T+ AI ++ ++L +P RR+ D HP+ Sbjct: 233 ----YPRFLSTE--------AISIMRRLLRRNPERRLGASEKDAEDVKKHPFFR 274 >1U59-A nrPDB Length = 287 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK-KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G G +G V + + + + K+ K D + +RE +++ +D+ IV + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 77 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQ-IIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + + E+ LH+ ++ + + + L+Q+ G+KY+ N Sbjct: 78 VCQA------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 131 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRW---YRAPELLLNSSDY 241 +HRDL N+LL KI DFGL++ D + T +W + APE +N + Sbjct: 132 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 190 Query: 242 TAAIDVWSVGCIFMELM 258 ++ DVWS G E + Sbjct: 191 SSRSDVWSYGVTMWEAL 207 >1U54-B nrPDB Length = 291 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 89/198 (44%), Gaps = 15/198 (7%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRT-LREIKLLRHMDHENIVA 124 +G G++G+V S SVA+K + ++ +A +RE+ + +DH N++ Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 85 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 + ++ P ++ L+D +R +Q + Q+ G+ Y+ S Sbjct: 86 LYGVVLTPPMKMVTELAPLGSLLDR-----LRKHQGHFLLGTLSRYAVQVAEGMGYLESK 140 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEY-VVTRWYRAPELLLNSS 239 +HRDL NLLL +KI DFGL R ++D M E+ V + APE L + Sbjct: 141 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE-SLKTR 199 Query: 240 DYTAAIDVWSVGCIFMEL 257 ++ A D W G E+ Sbjct: 200 TFSHASDTWMFGVTLWEM 217 >1K9A-A nrPDB Length = 450 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 16/195 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + IGKG +G V + VA+K I N A+ L E ++ + H N+V + Sbjct: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHS 182 +I +YI E M L +RS L + F + ++Y+ Sbjct: 252 LGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 N +HRDL N+L++ + K+ DFGL + S + T + +W APE L ++ Sbjct: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKW-TAPE-ALREKKFS 364 Query: 243 AAIDVWSVGCIFMEL 257 DVWS G + E+ Sbjct: 365 TKSDVWSFGILLWEI 379 >1BYG-A nrPDB Length = 278 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 16/195 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + IGKG +G V + VA+K I N A+ L E ++ + H N+V + Sbjct: 26 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 79 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHS 182 +I +YI E M L +RS L + F + ++Y+ Sbjct: 80 LGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 135 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 N +HRDL N+L++ + K+ DFGL + S + T + +W APE L ++ Sbjct: 136 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKW-TAPE-ALREKKFS 192 Query: 243 AAIDVWSVGCIFMEL 257 DVWS G + E+ Sbjct: 193 TKSDVWSFGILLWEI 207 >4R7H-A nrPDB Length = 343 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 96/222 (43%), Gaps = 38/222 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI---DAKRTL-REIKLLRHM-DHENIV 123 +G GA+G V A + A+ K+A D K L E+K++ H+ HENIV Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN---------------QALSEEHCQ- 167 + Y Y DL +R + L +E + Sbjct: 118 NLLGACTHGGPVLVITEYCTY----GDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRP 173 Query: 168 -------YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDF 219 +F Q+ +G+ ++ S N +HRD+ N+LL KI DFGLAR + ++S++ Sbjct: 174 LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 233 Query: 220 MTE---YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + + + +W APE + +S YT DVWS G + E+ Sbjct: 234 IVKGNARLPVKWM-APESIFDSV-YTVQSDVWSYGILLWEIF 273 >3OMV-A nrPDB Length = 307 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 93/207 (44%), Gaps = 36/207 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G++G V + +V I K+ + + A R E+ +LR H NI+ Sbjct: 44 IGSGSFGTVYKG-KWHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHVNIL----- 95 Query: 129 IPPPLRNAFNDVYIAYELMD--TDLHQIIRSNQALSEEHCQYFLYQILR----------G 176 +++ Y D + Q + H Q +Q+ + G Sbjct: 96 -----------LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 144 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRWYRAPE 233 + Y+H+ N++HRD+K +N+ L+ +KI DFGLA V S S + + + + APE Sbjct: 145 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPE 204 Query: 234 L--LLNSSDYTAAIDVWSVGCIFMELM 258 + + +++ ++ DV+S G + ELM Sbjct: 205 VIRMQDNNPFSFQSDVYSYGIVLYELM 231 >4HZS-A nrPDB Length = 341 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 89/198 (44%), Gaps = 15/198 (7%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRT-LREIKLLRHMDHENIVA 124 +G G++G+V S SVA+K + ++ +A +RE+ + +DH N++ Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIR 79 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSA 183 + ++ P ++ L+D +R +Q + Q+ G+ Y+ S Sbjct: 80 LYGVVLTPPMKMVTELAPLGSLLDR-----LRKHQGHFLLGTLSRYAVQVAEGMGYLESK 134 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEY-VVTRWYRAPELLLNSS 239 +HRDL NLLL +KI DFGL R ++D M E+ V + APE L + Sbjct: 135 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE-SLKTR 193 Query: 240 DYTAAIDVWSVGCIFMEL 257 ++ A D W G E+ Sbjct: 194 TFSHASDTWMFGVTLWEM 211 >5HIE-A nrPDB Length = 302 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 93/199 (46%), Gaps = 25/199 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDHENIVA 124 IG G++G V + + VA+K + AF N++ R R + +L M + Sbjct: 44 IGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ 100 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + I+ + +Y +++T I + A Q +G+ Y+H+ + Sbjct: 101 L-AIVTQWCEGS--SLYHHLHIIETKFEMIKLIDIA----------RQTAQGMDYLHAKS 147 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRWYRAPEL--LLNSS 239 ++HRDLK +N+ L+ + +KI DFGLA V S S + + + APE+ + + + Sbjct: 148 IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN 207 Query: 240 DYTAAIDVWSVGCIFMELM 258 Y+ DV++ G + ELM Sbjct: 208 PYSFQSDVYAFGIVLYELM 226 >4FL3-A nrPDB Length = 635 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 62/110 (56%), Gaps = 5/110 (4%) Query: 151 LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 L++ ++ N+ + +++ ++Q+ G+KY+ +N +HRDL N+LL KI DFGL Sbjct: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 Query: 211 AR-VTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFME 256 ++ + ++ ++ +W + APE +N +++ DVWS G + E Sbjct: 516 SKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKSDVWSFGVLMWE 564 >2BUJ-A nrPDB Length = 317 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/223 (23%), Positives = 93/223 (41%), Gaps = 20/223 (8%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G++ + K+ I +G+G + V A+K+I + D + RE Sbjct: 21 GHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREAD 78 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-----TDLHQIIRSNQALSEEHCQ 167 + R +H NI+ + R A ++ ++ ++ ++ L+E+ Sbjct: 79 MHRLFNHPNILRLVAYCLRE-RGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQIL 137 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-------ARVTSESDFM 220 + L I RGL+ IH+ HRDLKP+N+LL + D G + ++ + Sbjct: 138 WLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTL 197 Query: 221 TEYVVTRW---YRAPELLLNSSDYT--AAIDVWSVGCIFMELM 258 ++ R YRAPEL S DVWS+GC+ +M Sbjct: 198 QDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM 240 >4M66-A nrPDB Length = 325 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 93/201 (46%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG +G+V A + N VA+K + ++K+ E+K + ++ +EN++ + + Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIV--------NSKKISWEVKAMVNLRNENVLLLLGV 79 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN--V 185 + + + M+ L +++ L +++ G+ Y+HS + + Sbjct: 80 TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPL 139 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLA-------RVTSESDFMTEYVVTRWYRAPELLLNS 238 LHRDLKPSN+LL+ K+ DFGL+ + + T Y PELL Sbjct: 140 LHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKV 199 Query: 239 S-DYTAAIDVWSVGCIFMELM 258 + + A DV+S G + ++ Sbjct: 200 NLKASKASDVYSFGILVWAVL 220 >3QGY-A nrPDB Length = 286 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 94/204 (46%), Gaps = 18/204 (8%) Query: 66 IMPIGKGAYGIVCSAMNSETN-ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 + IG G +G+V + N + VAIK I + + + E +++ + H +V Sbjct: 32 VQEIGSGQFGLV--HLGYWLNKDKVAIKTIK---EGSMSEDDFIEEAEVMMKLSHPKLVQ 86 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQAL-SEEHCQYFLYQILRGLKYIHS 182 + + L A + + +E M+ L +R+ + L + E + G+ Y+ Sbjct: 87 LYGVC---LEQA--PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSS 239 A V+HRDL N L+ N +K+ DFG+ R + + T T++ + +PE + + S Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQY-TSSTGTKFPVKWASPE-VFSFS 199 Query: 240 DYTAAIDVWSVGCIFMELMDRKPL 263 Y++ DVWS G + E+ + Sbjct: 200 RYSSKSDVWSFGVLMWEVFSEGKI 223 >4XI2-A nrPDB Length = 446 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 101/235 (42%), Gaps = 37/235 (15%) Query: 34 ENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKK 93 +N P+T G +G+ +E+ K + +G G +G+V VAIK Sbjct: 169 KNAPSTAGLG--------YGS-WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKM 218 Query: 94 IANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT---- 149 I + + + E K++ ++ HE +V + + ++I E M Sbjct: 219 IR---EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLL 270 Query: 150 ----DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 ++ ++ Q L E C+ + ++Y+ S LHRDL N L+N +K+ Sbjct: 271 NYLREMRHRFQTQQLL--EMCK----DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKV 324 Query: 206 CDFGLARVTSESDFMTEYVV---TRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 DFGL+R + ++ + RW +P +L S +++ D+W+ G + E+ Sbjct: 325 SDFGLSRYVLDDEYTSSVGSKFPVRW--SPPEVLMYSKFSSKSDIWAFGVLMWEI 377 >1LUF-A nrPDB Length = 343 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 48/226 (21%) Query: 69 IGKGAYGIVCSA-----MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG+GA+G V A + E VA+K + + A RE L+ D+ NIV Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMAEFDNPNIV 113 Query: 124 AIRDI--IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ---------------------- 159 + + + P+ F Y+AY DL++ +RS Sbjct: 114 KLLGVCAVGKPMCLLFE--YMAY----GDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPG 167 Query: 160 ----ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 215 + +E+ C Q+ G+ Y+ +HRDL N L+ N +KI DFGL+R Sbjct: 168 PPPLSCAEQLC--IARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 216 ESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 +D+ + + RW + N YT DVW+ G + E+ Sbjct: 226 SADYYKADGNDAIPIRWMPPESIFYNR--YTTESDVWAYGVVLWEI 269 >3LMG-A nrPDB Length = 344 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 91/217 (41%), Gaps = 17/217 (7%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 + IF+ T K ++ G G +G V + ES+ I ++K +++ + Sbjct: 22 KVLARIFKETELRKLKVL--GSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK-SGRQSFQ 78 Query: 110 EIK----LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEH 165 + + +DH +IV + + P + + Y + + L + + AL + Sbjct: 79 AVTDHMLAIGSLDHAHIVRLLGLCP----GSSLQLVTQYLPLGSLLDHVRQHRGALGPQL 134 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY-- 223 + QI +G+ Y+ ++HR+L N+LL + +++ DFG+A + D Y Sbjct: 135 LLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSE 194 Query: 224 --VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 +W ++ YT DVWS G ELM Sbjct: 195 AKTPIKWMALES--IHFGKYTHQSDVWSYGVTVWELM 229 >4X7Q-B nrPDB Length = 312 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 85/200 (42%), Gaps = 15/200 (7%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN----AFDNKIDAKRTLREIKLLRHMD----HE 120 +GKG +G V + VAIK I + D+ E+ LL + H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 ++ + D + F V + L DL I L E + F Q++ +++ Sbjct: 99 GVIRLLDWFE--TQEGFMLV-LERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHC 155 Query: 181 HSANVLHRDLKPSNLL--LNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 HS V+HRD+K N+L L C K+ DFG + + + T++ TR Y PE + Sbjct: 156 HSRGVVHRDIKDENILIDLRRGC-AKLIDFGSGALLHDEPY-TDFDGTRVYSPPEWISRH 213 Query: 239 SDYTAAIDVWSVGCIFMELM 258 + VWS+G + +++ Sbjct: 214 QYHALPATVWSLGILLYDMV 233 >5C26-A nrPDB Length = 299 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 62/110 (56%), Gaps = 5/110 (4%) Query: 151 LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 L++ ++ N+ + +++ ++Q+ G+KY+ +N +HRDL N+LL KI DFGL Sbjct: 114 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 173 Query: 211 AR-VTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFME 256 ++ + ++ ++ +W + APE +N +++ DVWS G + E Sbjct: 174 SKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKSDVWSFGVLMWE 222 >6BSD-A nrPDB Length = 876 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 21/170 (12%) Query: 108 LREIKLLRHMDHENI-----VAIRD----IIPPPLRNA-FNDVYIAYELMDTDLHQIIRS 157 L+E+K++ + NI V ++D +I + N N A++L D Sbjct: 633 LKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGD 692 Query: 158 NQALSEEHCQYFLY-----QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 212 QA Y + QI G++Y+ + N +HRDL N L+ N +KI DFG++R Sbjct: 693 GQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 752 Query: 213 VTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 D+ + RW +L+ +T A DVW+ G E++ Sbjct: 753 NLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVL 800 >6E4F-A nrPDB Length = 290 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 93/213 (43%), Gaps = 28/213 (13%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 +E+ K + +G G +G+V VAIK I + + + E K++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMM 81 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT--------DLHQIIRSNQALSEEHCQ 167 ++ HE +V + + ++I E M ++ ++ Q L E C+ Sbjct: 82 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLL--EMCK 134 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV-- 225 + ++Y+ S LHRDL N L+N +K+ DFGL+R + ++ + Sbjct: 135 ----DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKF 190 Query: 226 -TRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 RW PE+L+ S +++ D+W+ G + E+ Sbjct: 191 PVRW-SPPEVLMYSK-FSSKSDIWAFGVLMWEI 221 >5GNK-A nrPDB Length = 297 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 89/203 (43%), Gaps = 19/203 (9%) Query: 66 IMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ + Sbjct: 24 IKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDNPH 82 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELM--DTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 + + I + V + +LM L + + ++ + QI +G+ Y Sbjct: 83 VCRLLGIC------LTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 136 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARV--TSESDFMTE--YVVTRWYRAPELL 235 + ++HRDL N+L+ +KI DFGLA++ E ++ E V +W +L Sbjct: 137 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 236 LNSSDYTAAIDVWSVGCIFMELM 258 YT DVWS G ELM Sbjct: 197 --HRIYTHQSDVWSYGVTVWELM 217 >6O8B-A nrPDB Length = 665 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 91/201 (45%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 80 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 81 IEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 185 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 238 ++HR++KP N++ + K+ DFG AR + + E T Y P++ + Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 239 -----SDYTAAIDVWSVGCIF 254 Y A +D+WS+G F Sbjct: 199 RKDHQKKYGATVDLWSIGVTF 219 >3LZB-A nrPDB Length = 327 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 89/203 (43%), Gaps = 19/203 (9%) Query: 66 IMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ + Sbjct: 20 IKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDNPH 78 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELM--DTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 + + I + V + +LM L + + ++ + QI +G+ Y Sbjct: 79 VCRLLGIC------LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 132 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARV--TSESDFMTE--YVVTRWYRAPELL 235 + ++HRDL N+L+ +KI DFGLA++ E ++ E V +W +L Sbjct: 133 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 236 LNSSDYTAAIDVWSVGCIFMELM 258 YT DVWS G ELM Sbjct: 193 --HRIYTHQSDVWSYGVTVWELM 213 >2Y4I-B nrPDB Length = 319 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 95/215 (44%), Gaps = 31/215 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD- 127 IGKG +G V + + VAI+ I DN+ K RE+ R HEN+V Sbjct: 41 IGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 128 -IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANV 185 + PP L I L+ ++R + L + +I++G+ Y+H+ + Sbjct: 98 CMSPPHL------AIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGI 151 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTS------ESDFMTEYVVTRW--YRAPELLLN 237 LH+DLK N+ + N + I DFGL ++ D + + W + APE++ Sbjct: 152 LHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLR--IQNGWLCHLAPEIIRQ 208 Query: 238 SS--------DYTAAIDVWSVGCIFMELMDRKPLF 264 S ++ DV+++G I+ EL R+ F Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 243 >5TE0-A nrPDB Length = 347 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 99/228 (43%), Gaps = 29/228 (12%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 G +F + + + +G + IV + + A+K++ +N+ D + REI Sbjct: 10 IGRVFGIGRQQVTVDEVLAEGGFAIV-FLVRTSNGMKCALKRMF--VNNEHDLQVCKREI 66 Query: 112 KLLRHMD-HENIVAIRDIIPPPLRN-AFNDVYIAYELMD-TDLHQII-----RSNQALSE 163 +++R + H+NIV D + N + DV+ LMD Q++ R +E Sbjct: 67 QIMRDLSGHKNIVGYID---SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTE 123 Query: 164 EHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLAR--------- 212 + +H ++HRDLK N+LL+ +CDFG A Sbjct: 124 NEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTE 183 Query: 213 -VTSESDFMTEYVVTRWYRAPEL--LLNSSDYTAAIDVWSVGCIFMEL 257 V + D + +Y T YRAPE+ L + T D+W++GC+ +L Sbjct: 184 GVNAVEDEIKKY-TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >4OTD-A nrPDB Length = 341 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 11/206 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL----REIKLLRHMDHENIVA 124 +G+G +G V + + E AIK + D +L R + + H +V Sbjct: 20 LGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVN 79 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + P F Y A DL I S+ SE ++ ++ GL+++H Sbjct: 80 LFGCFQTPEHVCFVMEYSA----GGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHK 134 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 +++RDLK NLLL+ +KI DFGL + D + + T + APE+L ++S YT Sbjct: 135 IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS-YTR 193 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDH 269 A+D W +G + E++ + FPG D Sbjct: 194 AVDWWGLGVLLYEMLVGESPFPGDDE 219 >4EUT-A nrPDB Length = 396 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 90/201 (44%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 74 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 75 IEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 185 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 238 ++HR++KP N++ + K+ DFG AR + + T Y P++ + Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 239 -----SDYTAAIDVWSVGCIF 254 Y A +D+WS+G F Sbjct: 193 RKDHQKKYGATVDLWSIGVTF 213 >4EUU-A nrPDB Length = 319 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 90/201 (44%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 74 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 75 IEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 185 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 238 ++HR++KP N++ + K+ DFG AR + + T Y P++ + Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 239 -----SDYTAAIDVWSVGCIF 254 Y A +D+WS+G F Sbjct: 193 RKDHQKKYGATVDLWSIGVTF 213 >4Y93-A nrPDB Length = 446 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 45/200 (22%), Positives = 88/200 (44%), Gaps = 28/200 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G+V VAIK I + + + E K++ ++ HE +V + + Sbjct: 196 LGTGQFGVV-KYGKWRGQYDVAIKMIK---EGSMSEDEFIEEAKVMMNLSHEKLVQLYGV 251 Query: 129 IPPPLRNAFNDVYIAYELMDT--------DLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 ++I E M ++ ++ Q L E C+ + ++Y+ Sbjct: 252 CTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLL--EMCK----DVCEAMEYL 300 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY---VVTRWYRAPELLLN 237 S LHRDL N L+N +K+ DFG+ R + ++ + +W +PE+L+ Sbjct: 301 ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKW-ASPEVLMY 359 Query: 238 SSDYTAAIDVWSVGCIFMEL 257 S +++ D+W+ G + E+ Sbjct: 360 SK-FSSKSDIWAFGVLMWEI 378 >4JLC-A nrPDB Length = 657 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 90/201 (44%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + A+K N +F +D + +RE ++L+ ++H+NIV + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 73 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 74 IEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 185 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 238 ++HRD+KP N++ + K+ DFG AR + + T Y P++ + Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 239 -----SDYTAAIDVWSVGCIF 254 Y A +D+WSVG F Sbjct: 192 RKDHQKKYGATVDLWSVGVTF 212 >3I81-A nrPDB Length = 315 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 104/232 (44%), Gaps = 31/232 (13%) Query: 69 IGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 +G+G++G+V + E VAIK + A + + L E +++ + ++V Sbjct: 26 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR-ERIEFLNEASVMKEFNCHHVV 84 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS-------NQALSEEHCQYFLY---Q 172 + ++ + + ELM DL +RS N L+ + + Sbjct: 85 RLLGVV-----SQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGE 139 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----YVVTRW 228 I G+ Y+++ +HRDL N ++ + +KI DFG+ R E+D+ + + RW Sbjct: 140 IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW 199 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMEL--MDRKPLFPGRDHVHQLRLLME 278 +PE L + +T DVWS G + E+ + +P + G + LR +ME Sbjct: 200 M-SPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQP-YQGLSNEQVLRFVME 248 >3BBT-B nrPDB Length = 328 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 84/201 (41%), Gaps = 21/201 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK---KIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G GA+G V + E+V I KI N + E ++ MDH ++V + Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 82 Query: 126 RDIIPPPLRNAFNDVYIAYELM--DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + P + + +LM L + + + + QI +G+ Y+ Sbjct: 83 LGVCLSP------TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER 136 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY------VVTRWYRAPELLLN 237 ++HRDL N+L+ + +KI DFGLAR+ + EY + +W ++ Sbjct: 137 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDE--KEYNADGGKMPIKWMALE--CIH 192 Query: 238 SSDYTAAIDVWSVGCIFMELM 258 +T DVWS G ELM Sbjct: 193 YRKFTHQSDVWSYGVTIWELM 213 >6FEX-A nrPDB Length = 321 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 42/170 (24%), Positives = 75/170 (44%), Gaps = 27/170 (15%) Query: 108 LREIKLLRHMDHENIVAIRDII--PPPLRNAFNDVYIAYELMDTDLHQIIRSNQ------ 159 L+E+K++ + NI+ + + PL I + + DL+Q + ++Q Sbjct: 78 LKEVKIMSRLKDPNIIRLLGVCVQDDPL------CMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 160 -------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 212 +S + QI G++Y+ + N +HRDL N L+ N +KI DFG++R Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 Query: 213 VTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 D+ + RW +L+ +T A DVW+ G E++ Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVL 239 >5FM2-A nrPDB Length = 355 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 50/94 (53%), Gaps = 6/94 (6%) Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----YV 224 F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R E D + + Sbjct: 196 FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRI 255 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 +W A E L + YT DVWS G + E++ Sbjct: 256 PVKWM-AIESLFDHI-YTTQSDVWSFGVLLWEIV 287 >5AMN-A nrPDB Length = 299 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 6/104 (5%) Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 +AL+ F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R E D Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 190 Query: 219 FMTE----YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + + +W A E L + YT DVWS G + E++ Sbjct: 191 SYVKRSQGRIPVKWM-AIESLFDHI-YTTQSDVWSFGVLLWEIV 232 >4Y83-A nrPDB Length = 332 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/289 (24%), Positives = 120/289 (41%), Gaps = 51/289 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 I +GA+G V A + +T + +A K I +D + ++++ HENI + Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIP------VDQFKP-SDVEIQACFRHENIAELYGA 133 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 + L +++ + L ++ S + E + +L+GL ++HS V+H Sbjct: 134 V---LWGETVHLFMEAGEGGSVLEKL-ESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHH 189 Query: 189 DLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 247 D+KPSN++ + + + DFGL+ ++T + F + T Y +PE++L T A D+ Sbjct: 190 DIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKA-DI 247 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 +S+G + + GTP KRY R P Sbjct: 248 YSLGATLIHMQ---------------------TGTPPW---------VKRYPRSAYPSYL 277 Query: 308 QSITDKFPTVHPLAID-------LIEKMLTFDPRRRITVLDALAHPYLN 349 I + P + +A D LIE L +P R D L H LN Sbjct: 278 YIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN 326 >4XLV-A nrPDB Length = 328 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 99/222 (44%), Gaps = 28/222 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSA-----MNSETNESVAIKKIANAFDNKIDAKRTLRE 110 +EV+ + + +G+G++G+V + E VA+K + N + + L E Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV-NESASLRERIEFLNE 92 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSE------ 163 +++ ++V + ++ + + ELM DL +RS + +E Sbjct: 93 ASVMKGFTCHHVVRLLGVV-----SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRP 147 Query: 164 ----EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF 219 + +I G+ Y+++ +HRDL N ++ + +KI DFG+ R E+D+ Sbjct: 148 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 207 Query: 220 MTE----YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + + RW APE L + +T + D+WS G + E+ Sbjct: 208 YRKGGKGLLPVRWM-APESLKDGV-FTTSSDMWSFGVVLWEI 247 >6NT9-A nrPDB Length = 742 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 90/201 (44%), Gaps = 19/201 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR--SNQ-ALSEEHCQYFLYQILRGLKYIHSAN 184 I + V I L+ ++ SN L E L ++ G+ ++ Sbjct: 73 IEEET--TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 185 VLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-- 238 ++HR++KP N++ + K+ DFG AR + + T Y P++ + Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 239 -----SDYTAAIDVWSVGCIF 254 Y A +D+WS+G F Sbjct: 191 RKDHQKKYGATVDLWSIGVTF 211 >4LRM-A nrPDB Length = 334 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 89/203 (43%), Gaps = 16/203 (7%) Query: 66 IMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ Sbjct: 24 IKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDNPG 82 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELM--DTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 + ++ L + V + +LM L + + ++ + QI +G+ Y Sbjct: 83 NPHVCRLLGICLTST---VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNY 139 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARV--TSESDFMTE--YVVTRWYRAPELL 235 + ++HRDL N+L+ +KI DFGLA++ E ++ E V +W +L Sbjct: 140 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 199 Query: 236 LNSSDYTAAIDVWSVGCIFMELM 258 YT DVWS G ELM Sbjct: 200 --HRIYTHQSDVWSYGVTVWELM 220 >3ZZW-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 95/213 (44%), Gaps = 33/213 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR-HMDHENIVAIRD 127 GK G + E ++VAIK + + + + + R +LR + H N+V + Sbjct: 22 FGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL--REEFRHEAMLRARLQHPNVVCLLG 79 Query: 128 IIPP--PLRNAFNDVYIAYELMDTDLHQ--IIRS--------------NQALSEEHCQYF 169 ++ PL F+ Y ++ DLH+ ++RS AL + Sbjct: 80 VVTKDQPLSMIFS--YCSH----GDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 133 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM----TEYVV 225 + QI G++Y+ S +V+H+DL N+L+ ++KI D GL R +D+ + Sbjct: 134 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 193 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 RW APE ++ ++ D+WS G + E+ Sbjct: 194 IRWM-APEAIMYGK-FSIDSDIWSYGVVLWEVF 224 >1FVR-A nrPDB Length = 327 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 7/101 (6%) Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 LS + +F + RG+ Y+ +HRDL N+L+ N KI DFGL+R + ++ Sbjct: 139 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYV 196 Query: 221 TEYVV---TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + + RW LN S YT DVWS G + E++ Sbjct: 197 KKTMGRLPVRWMAIES--LNYSVYTTNSDVWSYGVLLWEIV 235 >3PP0-A nrPDB Length = 338 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 36/111 (32%), Positives = 54/111 (48%), Gaps = 11/111 (9%) Query: 155 IRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 +R N+ L + + QI +G+ Y+ ++HRDL N+L+ + +KI DFGLAR+ Sbjct: 109 VRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARL 168 Query: 214 TSESDFMTEY------VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + TEY V +W +L +T DVWS G ELM Sbjct: 169 LDIDE--TEYHADGGKVPIKWMALESILRRR--FTHQSDVWSYGVTVWELM 215 >3Q4U-A nrPDB Length = 301 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 94/218 (43%), Gaps = 40/218 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH--MDHENIVAI- 125 +GKG YG V S E+VA+K ++ D K RE +L + HENI+ Sbjct: 16 VGKGRYGEVWRG--SWQGENVAVKIFSSR-----DEKSWFRETELYNTVMLRHENILGFI 68 Query: 126 -RDIIPPPLRNAFNDVYIA--YELMDT--DLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 D+ R++ +++ Y M + D Q+ L C + I GL ++ Sbjct: 69 ASDMTS---RHSSTQLWLITHYHEMGSLYDYLQLT----TLDTVSCLRIVLSIASGLAHL 121 Query: 181 H--------SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY-----VVTR 227 H + HRDLK N+L+ N I D GLA + S+S + V T+ Sbjct: 122 HIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 228 WYRAPELL-----LNSSDYTAAIDVWSVGCIFMELMDR 260 Y APE+L ++ D +D+W+ G + E+ R Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR 219 >5L2Q-C nrPDB Length = 320 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 86/194 (44%), Gaps = 31/194 (15%) Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-LKICDFGL 210 H +I+ + LSE Y ++R ++ +H N++HRDLK N++LN + I +F L Sbjct: 142 HYVIKEKR-LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCL 200 Query: 211 AR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 + + SE D + + + Y +P++L D+W++G + ++ + FP D Sbjct: 201 GKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDS 258 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 + Q EL F A Y +P R V + LI K+L Sbjct: 259 IPQ-----EL----------FRKIKAAEYT--IPEDGR---------VSENTVCLIRKLL 292 Query: 330 TFDPRRRITVLDAL 343 DP++R+ D L Sbjct: 293 VLDPQQRLAAADVL 306 >4LQP-A nrPDB Length = 508 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 73/157 (46%), Gaps = 25/157 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + IGKGA+G V +T KI A +TL + ++ + ++ A Sbjct: 107 VKVIGKGAFGEVRLVQKKDTG--------------KIYAMKTLLKSEMYKKDQLAHVKAE 152 Query: 126 RDIIPPP-------LRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQIL 174 RD++ L +F D Y +M+ DL ++ Q +E+ ++++ + + Sbjct: 153 RDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 212 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 211 ++ IH +HR +KP N+L++ +K+ DFGL+ Sbjct: 213 LAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 >6BFN-A nrPDB Length = 342 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 91/208 (43%), Gaps = 21/208 (10%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT--LREIKLLRHMDHENIVA 124 + IG+G +G V A+ N A+K++ D + A + L E++ L H NIV Sbjct: 28 LKIGEGGFGCVYRAVMR--NTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV- 84 Query: 125 IRDIIPPPLRNAFNDVYIAY---ELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 D +N F + + ++ LH ++ LS L R ++++H Sbjct: 85 --DFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 182 --SANVLHRDLKPSNLLLNANCDLKICDFGLARVT-------SESDFMTEYVVTRWYRA- 231 S +++H D+K SN+LL+ K+ DFGLAR + S+S + R A Sbjct: 143 QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 232 -PELLLNSSDYTAAIDVWSVGCIFMELM 258 PE + + D +S G + +E + Sbjct: 203 LPEEYIKTGRLAVDTDTFSFGVVVLETL 230 >3SXS-A nrPDB Length = 268 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 86/194 (44%), Gaps = 16/194 (8%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G+V + VA+K I + + +E + + + H +V + Sbjct: 16 LGSGQFGVV-KLGKWKGQYDVAVKMIK---EGSMSEDEFFQEAQTMMKLSHPKLVKFYGV 71 Query: 129 IPPPLRNAFNDVYIAYELMDTD-LHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVL 186 +YI E + L +RS+ + L Y + G+ ++ S + Sbjct: 72 CSKEY-----PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 126 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTA 243 HRDL N L++ + +K+ DFG+ R + +++ V T++ + APE + + Y++ Sbjct: 127 HRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAPE-VFHYFKYSS 184 Query: 244 AIDVWSVGCIFMEL 257 DVW+ G + E+ Sbjct: 185 KSDVWAFGILMWEV 198 >3UIM-A nrPDB Length = 326 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 89/201 (44%), Gaps = 8/201 (3%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+G +G V ++ VA+K++ + + E++++ H N++ +R Sbjct: 38 LGRGGFGKVYKGRLADGT-LVAVKRLKEERTQGGELQFQT-EVEMISMAVHRNLLRLRGF 95 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA---NV 185 P Y+A + + L + S L Q RGL Y+H + Sbjct: 96 CMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKI 155 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV--TRWYRAPELLLNSSDYTA 243 +HRD+K +N+LL+ + + DFGLA++ D V T + APE L++ + Sbjct: 156 IHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPE-YLSTGKSSE 214 Query: 244 AIDVWSVGCIFMELMDRKPLF 264 DV+ G + +EL+ + F Sbjct: 215 KTDVFGYGVMLLELITGQRAF 235 >5IKW-A nrPDB Length = 310 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 76/177 (42%), Gaps = 19/177 (10%) Query: 99 DNKIDAKRTLREIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTD--LHQII 155 +N D REI +++ + H+NIV D + + +V I E ++Q+ Sbjct: 49 NNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMN 108 Query: 156 RSNQ-ALSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLAR 212 + Q +E + +H ++HRDLK N+LLN + +CDFG A Sbjct: 109 KKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSAT 168 Query: 213 ----------VTSESDFMTEYVVTRWYRAPEL--LLNSSDYTAAIDVWSVGCIFMEL 257 V + + +Y T YRAPE+ L T D+W++GC+ +L Sbjct: 169 NKFLNPQKDGVNVVEEEIKKY-TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >5U6C-A nrPDB Length = 315 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 29/219 (13%) Query: 69 IGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G+G +G V T+ VA+K + ++ + + L E ++ H N++ + Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 126 RDI--------IPPPLR----NAFNDV--YIAYELMDTDLHQIIRSNQALSEEHCQYFLY 171 + IP P+ + D+ Y+ Y ++T I Q L + F+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI--PLQTLLK-----FMV 156 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW--- 228 I G++Y+ + N LHRDL N +L + + + DFGL++ D+ + + + Sbjct: 157 DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK 216 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL-FPG 266 + A E L + YT+ DVW+ G E+ R +PG Sbjct: 217 WIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPG 254 >4Y12-A nrPDB Length = 375 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 109/247 (44%), Gaps = 24/247 (9%) Query: 69 IGKGAYGIVCSAMNSETN-ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 I G G + A++ N V +K + ++ D + A + L + H +IV I + Sbjct: 127 IAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-QFLAEVVHPSIVQIFN 185 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVL 186 + R+ YI E + + RS Q L +L +IL L Y+HS ++ Sbjct: 186 FVEHTDRHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLV 243 Query: 187 HRDLKPSNLLLNANCDLKICDFG-LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 + DLKP N++L LK+ D G ++R+ S F Y T ++APE++ T A Sbjct: 244 YNDLKPENIMLTEE-QLKLIDLGAVSRINS---FGYLY-GTPGFQAPEIVRTGP--TVAT 296 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ-LPP 304 D+++VG L P GR + G P ++ + ++ R +R+ + P Sbjct: 297 DIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLLRRAIDP 346 Query: 305 YPRQSIT 311 PRQ T Sbjct: 347 DPRQRFT 353 >5KMM-A nrPDB Length = 329 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 36/215 (16%) Query: 69 IGKGAYGIV----CSAMNSETNES-VAIKKIANAFDNKIDAKRTL-REIKLLRHMDHENI 122 +G+GA+G V C + E ++ VA+K + A ++ A++ RE +LL + H++I Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA---------------LSEEHC 166 V + + + +E M DL++ +RS+ L Sbjct: 100 VRFFGVC-----TEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQL 154 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT 226 Q+ G+ Y+ + +HRDL N L+ +KI DFG++R +D+ T Sbjct: 155 LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT 214 Query: 227 ----RWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 RW PE +L +T DVWS G + E+ Sbjct: 215 MLPIRWM-PPESILYRK-FTTESDVWSFGVVLWEI 247 >2QKW-B nrPDB Length = 321 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 47/87 (54%), Gaps = 4/87 (4%) Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTRWYRA 231 RGL Y+H+ ++HRD+K N+LL+ N KI DFG+++ +E D T T Y Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYID 209 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELM 258 PE + T DV+S G + E++ Sbjct: 210 PEYFIKGR-LTEKSDVYSFGVVLFEVL 235 >4BTK-A nrPDB Length = 337 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/181 (29%), Positives = 81/181 (44%), Gaps = 21/181 (11%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S GG Q +I + V ++K + IG G +G + AM+ T E+VA+K + +A Sbjct: 38 MSGGGE--QADILPANYVVKDRWKV-LKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQ 93 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN- 158 K K + +K L+ DH + I FN Y+ +L +L + RS Sbjct: 94 PKQVLKMEVAVLKKLQGKDH-----VCRFIGCGRNEKFN--YVVMQLQGRNLADLRRSQP 146 Query: 159 -QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN------ANCDLKICDFGLA 211 + QIL ++ IHS LHRD+KPSN + C + DFGLA Sbjct: 147 RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKC--YMLDFGLA 204 Query: 212 R 212 R Sbjct: 205 R 205 >4NFN-A nrPDB Length = 309 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/181 (29%), Positives = 81/181 (44%), Gaps = 21/181 (11%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S GG Q +I + V ++K + IG G +G + AM+ T E+VA+K + +A Sbjct: 3 MSGGGE--QADILPANYVVKDRWKV-LKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQ 58 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN- 158 K K + +K L+ DH + I FN Y+ +L +L + RS Sbjct: 59 PKQVLKMEVAVLKKLQGKDH-----VCRFIGCGRNEKFN--YVVMQLQGRNLADLRRSQP 111 Query: 159 -QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN------ANCDLKICDFGLA 211 + QIL ++ IHS LHRD+KPSN + C + DFGLA Sbjct: 112 RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKC--YMLDFGLA 169 Query: 212 R 212 R Sbjct: 170 R 170 >5WNO-A nrPDB Length = 330 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 6/94 (6%) Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMT---EYV 224 + YQI G++Y+ V+HRDL N+L+ ++I DFGL+++ ++D +T V Sbjct: 129 YCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKV 188 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 +W + + YT A DVW+ G E++ Sbjct: 189 AIKWLAIE--IFSKHCYTHASDVWAFGVTCWEII 220 >3G2F-A nrPDB Length = 336 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 73/269 (27%), Positives = 118/269 (43%), Gaps = 45/269 (16%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG+G YG V E +V + AN N I+ K R + M+H+NI R I Sbjct: 21 IGRGRYGAVYKGSLDERPVAVKVFSFANR-QNFINEKNIYR----VPLMEHDNIA--RFI 73 Query: 129 IPPPLRNAFNDVYIAYELM-----DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + A D + Y L+ + L + + + + C+ + + RGL Y+H+ Sbjct: 74 VGDERVTA--DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCR-LAHSVTRGLAYLHTE 130 Query: 184 ---------NVLHRDLKPSNLLLNANCDLKICDFGLA-RVTS--------ESDFMTEYVV 225 + HRDL N+L+ + I DFGL+ R+T E + V Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVG 190 Query: 226 TRWYRAPELL---LNSSDYTAA---IDVWSVGCIFMELMDR-KPLFPGRDH-VHQLRLLM 277 T Y APE+L +N D +A +D++++G I+ E+ R LFPG +Q+ Sbjct: 191 TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQT 250 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYP 306 E+ P+ E+++ L K Q P +P Sbjct: 251 EVGNHPTFEDMQVLVSREK----QRPKFP 275 >2PZI-A nrPDB Length = 681 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 109/247 (44%), Gaps = 24/247 (9%) Query: 69 IGKGAYGIVCSAMNSETN-ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 I G G + A++ N V +K + ++ D + A + L + H +IV I + Sbjct: 88 IAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-QFLAEVVHPSIVQIFN 146 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVL 186 + R+ YI E + + RS Q L +L +IL L Y+HS ++ Sbjct: 147 FVEHTDRHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLV 204 Query: 187 HRDLKPSNLLLNANCDLKICDFG-LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 + DLKP N++L LK+ D G ++R+ S F Y T ++APE++ T A Sbjct: 205 YNDLKPENIMLTEE-QLKLIDLGAVSRINS---FGYLY-GTPGFQAPEIVRTGP--TVAT 257 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ-LPP 304 D+++VG L P GR + G P ++ + ++ R +R+ + P Sbjct: 258 DIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKTYDSYGRLLRRAIDP 307 Query: 305 YPRQSIT 311 PRQ T Sbjct: 308 DPRQRFT 314 >3SOC-A nrPDB Length = 322 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 98/241 (40%), Gaps = 33/241 (13%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR---EIKLLRHMDHENIVAIRD 127 +G +G V A NE VA+K I K++ + E+ L M HENI+ Sbjct: 34 RGRFGCVWKA--QLLNEYVAVKIFP------IQDKQSWQNEYEVYSLPGMKHENIL---Q 82 Query: 128 IIPPPLRNAFNDV---YIAYELMDTDLHQIIRSNQALSEEHCQY---------FLYQILR 175 I R DV I L +++N E C +L++ + Sbjct: 83 FIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAP 232 GLK H + HRD+K N+LL N I DFGLA + V TR Y AP Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAP 202 Query: 233 ELLLNS----SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 E+L + D ID++++G + EL R G + L E+ PS E++ Sbjct: 203 EVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM 262 Query: 289 E 289 + Sbjct: 263 Q 263 >5WNL-A nrPDB Length = 342 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 67/284 (23%), Positives = 115/284 (40%), Gaps = 50/284 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G G +G V + +AIK + + + L E K + I+ + I Sbjct: 28 VGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGI 87 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH--SANVL 186 P V + E M+T + + +++ L + +++ G+ ++H S +L Sbjct: 88 CQEP-------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLL 140 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVTSESD----FMTEYVVTRWYRAPELLLNSSD-- 240 H +LKP+N+LL+A+ +KI DFGLA+ S M T Y PE + S Sbjct: 141 HLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLF 200 Query: 241 ------YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 Y+ AI +W V L +KP D + L ++M+++ Sbjct: 201 DTKHDVYSFAIVIWGV------LTQKKPF---ADEKNILHIMMKVV-------------- 237 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 K + +LPP R P I L+++ DP+ R T Sbjct: 238 -KGHRPELPPICRPR-----PRACASLIGLMQRCWHADPQVRPT 275 >5CEK-A nrPDB Length = 263 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 54/238 (22%), Positives = 93/238 (39%), Gaps = 39/238 (16%) Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NI I ++I Y+ +E D+H +RS + L EE QI+ + Sbjct: 59 SHSNITGIVEVI-----LGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 178 KYIHSANVLHRDLKPSNLLLNA--NCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPEL 234 + H + ++ DLK + + L++ + E D +++ Y +PE+ Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 235 LLNSSDYTA-AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L + Y+ A DVWS+G + L+ + F D PS L Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD--------------PSA-----LFS 214 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 +R +P + + P A LI +L +P R+T + L HP+ S+ Sbjct: 215 KIRRGQFCIPEH-----------ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >5J0A-A nrPDB Length = 300 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 85/186 (45%), Gaps = 23/186 (12%) Query: 90 AIKKI---ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 A+KKI N + KR + E K+L+ + H NIV R ND + + Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAF------TEANDGSLCLAM 94 Query: 147 ---MDTDLHQIIRSNQALSEEHCQYFL-----YQILRGLKYIHS-ANVLHRDLKPSNLLL 197 + L+ +I S++ + + RGLKY+H +LH D+K SN+++ Sbjct: 95 EYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVI 154 Query: 198 NANCD-LKICDFGLARVTSESDFMTE----YVVTRWYRAPELLLNSSDYTAAIDVWSVGC 252 + + +KICD G++ E+ +T+ Y+ T ++ E + + T D+++ G Sbjct: 155 KGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGL 214 Query: 253 IFMELM 258 E+M Sbjct: 215 TLWEMM 220 >4F0G-A nrPDB Length = 287 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 90/209 (43%), Gaps = 32/209 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTL-REIKLLRHMDHENIV 123 IGKG +G+V + VAIK + + I+ + RE+ ++ +++H NIV Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 124 AIRDII--PPPLRNAF---NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 + ++ PP + F D+Y H+++ + + I G++ Sbjct: 87 KLYGLMHNPPRMVMEFVPCGDLY----------HRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 179 YIHSAN--VLHRDLKPSNLLL-----NANCDLKICDFGLAR--VTSESDFMTEYVVTRWY 229 Y+ + N ++HRDL+ N+ L NA K+ DFGL++ V S S + + +W Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNF---QWM 193 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + YT D +S I ++ Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTIL 222 >6DC0-A nrPDB Length = 292 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 93/237 (39%), Gaps = 39/237 (16%) Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 H NI I ++I Y+ +E D+H +RS + L EE QI+ + Sbjct: 57 HSNITGIVEVI-----LGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 111 Query: 179 YIHSANVLHRDLKPSNLLLNA--NCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPELL 235 + H + ++ DLK + + L++ + E D +++ Y +PE+L Sbjct: 112 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEIL 171 Query: 236 LNSSDYTA-AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y+ A DVWS+G + L+ + F D PS L Sbjct: 172 NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD--------------PSA-----LFSK 212 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 +R +P + + P A LI +L +P R+T + L HP+ S+ Sbjct: 213 IRRGQFCIPEH-----------ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >4NEU-A nrPDB Length = 333 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 72/165 (43%), Gaps = 26/165 (15%) Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ 167 L E K++ + H +V + +I + + Y+ +L ++++ + Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYME----KGNLMHVLKAEMSTPLSVKG 125 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY---- 223 + +I+ G+ Y+H V+H+DLKP N+L++ + +KI D GLA S E Sbjct: 126 RIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNEL 185 Query: 224 ----------VVTRWYRAPELLLN--------SSDYTAAIDVWSV 250 T +Y APE L + S Y+ A+ +W++ Sbjct: 186 REVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAI 230 >5FQD-C nrPDB Length = 341 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 83/187 (44%), Gaps = 39/187 (20%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 102 GGR + F V KYK + IG G++G + A+N E VA+K + K Sbjct: 2 GGRMASSSGSKAEFIVGGKYKL-VRKIGSGSFGDIYLAINITNGEEVAVKLES----QKA 56 Query: 103 DAKRTLREIKLLRHM--------------DHENIVAIRDIIPPPLRNAFNDVYIAYELMD 148 + L E KL + + + + V + D++ P L + FN + + Sbjct: 57 RHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKT 116 Query: 149 TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NANCD-LKI 205 ++ ++Q +S ++Y+H+ N +HRD+KP N L+ +C+ L + Sbjct: 117 V----LMLADQMISR-------------IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFL 159 Query: 206 CDFGLAR 212 DFGLA+ Sbjct: 160 IDFGLAK 166 >3ZBF-A nrPDB Length = 322 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 101/249 (40%), Gaps = 50/249 (20%) Query: 33 IENIPA------TLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 IEN+PA TL + FG ++E TA I+ +G G + + + Sbjct: 24 IENLPAFPREKLTLR---LLLGSGAFGEVYEGTA---VDILGVGSGEIKVAVKTLKKGST 77 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 + I+ L+E L+ +H NI+ + L N YI EL Sbjct: 78 DQEKIE--------------FLKEAHLMSKFNHPNILKQLGVC---LLN--EPQYIILEL 118 Query: 147 MDT-DLHQIIRSNQALS-------EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 198 M+ DL +R + + I +G Y+ + +HRDL N L++ Sbjct: 119 MEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVS 178 Query: 199 AN-----CDLKICDFGLARVTSESDFMTE----YVVTRWYRAPELLLNSSDYTAAIDVWS 249 +KI DFGLAR ++D+ + + RW APE L++ +T DVWS Sbjct: 179 VKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWM-APESLMDGI-FTTQSDVWS 236 Query: 250 VGCIFMELM 258 G + E++ Sbjct: 237 FGILIWEIL 245 >3SV0-A nrPDB Length = 483 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/178 (27%), Positives = 78/178 (43%), Gaps = 47/178 (26%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 GN F + K IG G++G + N +TNE VAIK + N K + L E K Sbjct: 6 GNKFRLGRK-------IGSGSFGEIYLGTNIQTNEEVAIK-LENV---KTKHPQLLYESK 54 Query: 113 LLR--------------HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN 158 + R ++ + V + D++ P L + FN + Sbjct: 55 IYRILQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFC-----------------S 97 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN----ANCDLKICDFGLAR 212 + LS + Q++ ++++HS + LHRD+KP N L+ AN + I DFGLA+ Sbjct: 98 RKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRAN-QVYIIDFGLAK 154 >2VD5-A nrPDB Length = 412 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 71/150 (47%), Gaps = 20/150 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFD----NKIDAKRTLREIKLLRHMDHENIVA 124 IG+GA+ V +T + A+K I N +D ++ R R++ L + D I Sbjct: 69 IGRGAFSEVAVVKMKQTGQVYAMK-IMNKWDMLKRGEVSCFREERDV--LVNGDRRWITQ 125 Query: 125 IRDIIPPPLRNAFNDVYIAYELMD----TDLHQII-RSNQALSEEHCQYFLYQILRGLKY 179 L AF D Y +M+ DL ++ + + + E +++L +I+ + Sbjct: 126 --------LHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS 177 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFG 209 +H +HRD+KP N+LL+ +++ DFG Sbjct: 178 VHRLGYVHRDIKPDNILLDRCGHIRLADFG 207 >5AR8-A nrPDB Length = 326 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 91/208 (43%), Gaps = 14/208 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR--TLREIKLLRHMDHENIVAIR 126 + +GA G V SA +++ VA+K + + +D++R LRE ++L I+ I Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHL-HIHTPLLDSERKDVLREAEILHKARFSYILPIL 98 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN-- 184 I P Y+ ++ LH+ + L++I G+ Y+H+ Sbjct: 99 GICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFR-ILHEIALGVNYLHNMTPP 157 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV------TRWYRAPELLLNS 238 +LH DLK N+LL+ +KI DFGL++ S + T Y PE Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG 217 Query: 239 SDYTAAI--DVWSVGCIFMELMDRKPLF 264 A+I D++S I E++ RK F Sbjct: 218 QKSRASIKHDIYSYAVITWEVLSRKQPF 245 >3MDY-A nrPDB Length = 337 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 96/222 (43%), Gaps = 30/222 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 AK + IGKG YG V M E VA+K + + + + L+RH Sbjct: 36 AKQIQMVKQIGKGRYGEVW--MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRH--- 90 Query: 120 ENIVAIRDIIPPPLRN--AFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRG 176 ENI+ I ++ ++ +Y+ + + L+ ++S L + Y + G Sbjct: 91 ENILGF---IAADIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSVSG 146 Query: 177 LKYIHSA--------NVLHRDLKPSNLLLNANCDLKICDFGLA----RVTSESDF-MTEY 223 L ++H+ + HRDLK N+L+ N I D GLA T+E D Sbjct: 147 LCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTR 206 Query: 224 VVTRWYRAPELL---LNSSDYTAAI--DVWSVGCIFMELMDR 260 V T+ Y PE+L LN + + + I D++S G I E+ R Sbjct: 207 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARR 248 >4L68-A nrPDB Length = 340 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 69/129 (53%), Gaps = 15/129 (11%) Query: 141 YIAYELM-DTDLHQIIRSNQALSEEHCQYFL-YQILRGLKYIHSAN---VLHRDLKPSNL 195 ++ Y+ M + LH ++ SN+ + ++ + RGL ++H +LH+++ S + Sbjct: 111 FLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVI 170 Query: 196 LLNANCDLKICDFGLARV-----TSESDFMTEYVVTRWYRAPELLLNSSDYTAAI--DVW 248 L++ + D +I D GLAR+ +ES FMT + Y APE S+ A++ DV+ Sbjct: 171 LIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY---STTMLASLKGDVY 227 Query: 249 SVGCIFMEL 257 +G + +EL Sbjct: 228 GLGVVLLEL 236 >3MY0-A nrPDB Length = 305 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 30/213 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKG YG V + ESVA+K ++ + + + LLRH + +A D+ Sbjct: 16 VGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA-SDM 72 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH------- 181 RN+ +++ + Q L GL ++H Sbjct: 73 TS---RNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129 Query: 182 -SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE-SDFM----TEYVVTRWYRAPELL 235 + HRD K N+L+ +N I D GLA + S+ SD++ V T+ Y APE+L Sbjct: 130 GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL 189 Query: 236 --------LNSSDYTAAIDVWSVGCIFMELMDR 260 S +T D+W+ G + E+ R Sbjct: 190 DEQIRTDCFESYKWT---DIWAFGLVLWEIARR 219 >5VC6-A nrPDB Length = 289 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 88/226 (38%), Gaps = 23/226 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRD 127 IG G +G V + AIK+ +D + LRE+ + H ++V Sbjct: 19 IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFS 78 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 + Y + + + R E + L Q+ RGL+YIHS +++H Sbjct: 79 AWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVH 138 Query: 188 RDLKPSNLLL------NANCD-------------LKICDFGLARVTSESDFMTEYVVTRW 228 D+KPSN+ + NA + KI D G VT S E +R Sbjct: 139 MDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG--HVTRISSPQVEEGDSR- 195 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 + A E+L + + D++++ + +PL D H++R Sbjct: 196 FLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIR 241 >2QLU-A nrPDB Length = 314 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 105/242 (43%), Gaps = 34/242 (14%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIP 130 +G +G V A N+ VA+K I D + + ++ REI M HEN++ I Sbjct: 25 RGRFGCVWKA--QLMNDFVAVK-IFPLQDKQ--SWQSEREIFSTPGMKHENLL---QFIA 76 Query: 131 PPLRNAFNDV--YIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH------ 181 R + +V ++ D L ++ N E C + + RGL Y+H Sbjct: 77 AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELC-HVAETMSRGLSYLHEDVPWC 135 Query: 182 -----SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE-----SDFMTEYVVTRWYRA 231 ++ HRD K N+LL ++ + DFGLA V E D + V TR Y A Sbjct: 136 RGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA-VRFEPGKPPGDTHGQ-VGTRRYMA 193 Query: 232 PELLLNS----SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 PE+L + D ID++++G + EL+ R G + L E+ PS EE Sbjct: 194 PEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE 253 Query: 288 LE 289 L+ Sbjct: 254 LQ 255 >5E8V-A nrPDB Length = 316 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 93/220 (42%), Gaps = 37/220 (16%) Query: 69 IGKGAYGIVCSAM----NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +GKG + V A SE E+VA+K + + +T ++I ++ HENI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY---EEYASWKTEKDIFSDINLKHENILQ 73 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLH-----QIIRSNQALSEEHCQYFLYQILRGLKY 179 + + Y + T H Q + +S E + + RG+ + Sbjct: 74 F--LTAEERKTELGKQY----WLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH 127 Query: 180 IHSAN---------VLHRDLKPSNLLLNANCDLKICDFGLAR----VTSESDFM-TEYVV 225 +HS + ++HRDLK SN+L+ + +CDFGL+ S D + V Sbjct: 128 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 187 Query: 226 TRWYRAPELL-----LNSSDYTAAIDVWSVGCIFMELMDR 260 T Y APE+L L + + DV+S+ + E+ R Sbjct: 188 TARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >4M69-B nrPDB Length = 283 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 30/194 (15%) Query: 110 EIKLLRHMDHENI-----VAIRDIIPPP---LRNAFNDVYIAYELMD--TDLHQIIRSNQ 159 EIK ++ D NI + I + PP + + ++ EL+D DL +RS Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRS-- 115 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----- 214 + + RGL +H + LHR++ S+ L+ +K+ F L++ Sbjct: 116 --------LLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISR 167 Query: 215 SESDFMTEYVVTRWYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 + E + Y +PE L N Y +++S G + E+ K F G D Sbjct: 168 TAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS---- 223 Query: 274 RLLMELIGTPSEEE 287 + + EL+ ++E Sbjct: 224 KKIRELVAEDKKQE 237 >4BTF-A nrPDB Length = 469 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 30/194 (15%) Query: 110 EIKLLRHMDHENI-----VAIRDIIPPP---LRNAFNDVYIAYELMD--TDLHQIIRSNQ 159 EIK ++ D NI + I + PP + + ++ EL+D DL +RS Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRS-- 301 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----- 214 + + RGL +H + LHR++ S+ L+ +K+ F L++ Sbjct: 302 --------LLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISR 353 Query: 215 SESDFMTEYVVTRWYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 + E + Y +PE L N Y +++S G + E+ K F G D Sbjct: 354 TAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS---- 409 Query: 274 RLLMELIGTPSEEE 287 + + EL+ ++E Sbjct: 410 KKIRELVAEDKKQE 423 >4JRN-A nrPDB Length = 372 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/313 (19%), Positives = 119/313 (38%), Gaps = 80/313 (25%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIK-----------------KIANAFDNKIDAKRTLRE 110 P+G G + V A + ETNE +A+K + ++ + N AK Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 111 IKLLRHMDHENIV------AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR---SNQAL 161 + R M ++V A +++ + ++ + D+ ++I + ++ Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 162 SEEHC-----QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE 216 ++ Y Q ++ + + + ++H D+KP+N LL + L + DFG R+ + Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS 254 Query: 217 SDFMTEYVVTRWYRAPELLLNSSD--YTAAIDVWSVG----CIFMELMDRKPLFPGRDHV 270 + + T Y PE ++ YT D W +G CI+ + +P Sbjct: 255 ---VGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCK---ERP-------- 300 Query: 271 HQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 TP++ ++L + P P L DLI +L Sbjct: 301 -----------TPADGIWDYL------HFADCPSTPE------------LVQDLIRSLLN 331 Query: 331 FDPRRRITVLDAL 343 DP++R+ L AL Sbjct: 332 RDPQKRMLPLQAL 344 >2WTK-B nrPDB Length = 373 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 97/233 (41%), Gaps = 31/233 (13%) Query: 69 IGKGAYGI--VCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 IGKG + V A T E V +++I A N++ E+ + + +H NIV Sbjct: 17 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEM-VTFLQGELHVSKLFNHPNIV-- 73 Query: 126 RDIIPPPLRNAF---NDVYIAYELMDTDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKY 179 P R F N++++ M + + ++E Y L +L+ L Y Sbjct: 74 ------PYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 180 IHSANVLHRDLKPSNLLLNAN---------CDLKICDFGLARVTSESDFMTEYVVTRWYR 230 IH +HR +K S++L++ + +L + G R DF V + Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG-QRQRVVHDFPKYSVKVLPWL 186 Query: 231 APELL-LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 +PE+L N Y A D++SVG EL + P +D LL +L GT Sbjct: 187 SPEVLQQNLQGYDAKSDIYSVGITACELANGH--VPFKDMPATQMLLEKLNGT 237 >2CMW-A nrPDB Length = 310 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 30/46 (65%), Gaps = 5/46 (10%) Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLK-----ICDFGLAR 212 Q+L ++Y+HS N+++RD+KP N L+ + K I DFGLA+ Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >5VDK-A nrPDB Length = 297 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/187 (22%), Positives = 72/187 (38%), Gaps = 19/187 (10%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI---KLLRHMDHENI 122 + IG G +G V + AIK+ F + L E+ +L H H ++ Sbjct: 20 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH--HPHV 77 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 V + Y + + + +S E + L QI GL YIH+ Sbjct: 78 VRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHN 137 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR--WYRAPELLLNSSD 240 ++++H D+KPSN+ IC ++ SES + E V W+ + ++ D Sbjct: 138 SSMVHLDIKPSNIF--------ICH----KMQSESSGVIEEVENEADWFLSANVMYKIGD 185 Query: 241 YTAAIDV 247 A + Sbjct: 186 LGHATSI 192 >4TN6-A nrPDB Length = 318 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/44 (43%), Positives = 28/44 (63%), Gaps = 3/44 (6%) Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLAR 212 Q++ ++YIHS N +HRD+KP N L+ + I DFGLA+ Sbjct: 111 QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAK 154 >1PY5-A nrPDB Length = 326 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 10/86 (11%) Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFM----TEYVVTRWYRAPELLLNSS 239 + HRDLK N+L+ N I D GLA R S +D + V T+ Y APE+L +S Sbjct: 155 IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSI 214 Query: 240 DYT-----AAIDVWSVGCIFMELMDR 260 + D++++G +F E+ R Sbjct: 215 NMKHFESFKRADIYAMGLVFWEIARR 240 >5CLR-A nrPDB Length = 451 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 10/69 (14%) Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW- 228 + + +K H ++HRDLKP N++L+A+ + DFG +S SD E W Sbjct: 182 MISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG----SSSSD--KEPKPASWG 235 Query: 229 ---YRAPEL 234 Y APEL Sbjct: 236 TASYLAPEL 244 >5M07-A nrPDB Length = 276 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 67/166 (40%), Gaps = 28/166 (16%) Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFN-DVYIAYEL---MDTDLHQIIRSNQA 160 +R RE ++ + H +I+ + D R F+ ++IA + +D H R Sbjct: 75 RRFQRETEVAARLFHPHILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAV 128 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC--DLKI--CDFGLARVTSE 216 L + + L Y H +LHRD+ P+N++L + D +I DFG+A S Sbjct: 129 LPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPS- 187 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKP 262 Y APEL +D D +++ + L P Sbjct: 188 ------------YPAPELSAG-ADVDGRADQYALALTAIHLFAGAP 220 >2RSV-A nrPDB Length = 403 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 3/81 (3%) Query: 134 RNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKP 192 +N + ++ + +DL +I +N + S + +IL L+YIH +H D+K Sbjct: 128 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 193 SNLLLN-ANCD-LKICDFGLA 211 SNLLLN N D + + D+GLA Sbjct: 188 SNLLLNYKNPDQVYLVDYGLA 208 >4NT4-A nrPDB Length = 312 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 29/46 (63%), Gaps = 5/46 (10%) Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCD-----LKICDFGLAR 212 Q+L ++Y+HS ++++RD+KP N L+ + I DFGLA+ Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >4L00-A nrPDB Length = 304 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 32/152 (21%), Positives = 66/152 (43%), Gaps = 13/152 (8%) Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 ++R + H++IV + + + N + ++ +D +H R + L+ Q Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH---RKSDVLTTPWKFKVAKQ 141 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLL-----NANCD--LKICDFGLARVTSESDFMTEYVV 225 + L Y+ +++H ++ NLLL ++ C +K+ D G+ E + Sbjct: 142 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP 201 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + APE + +S + + A D WS G E+ Sbjct: 202 ---WIAPECVEDSKNLSVAADKWSFGTTLWEI 230 >2LAV-A nrPDB Length = 361 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 3/81 (3%) Query: 134 RNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKP 192 +N + ++ + +DL +I +N + S + +IL L+YIH +H D+K Sbjct: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 193 SNLLLN-ANCD-LKICDFGLA 211 SNLLLN N D + + D+GLA Sbjct: 181 SNLLLNYKNPDQVYLVDYGLA 201 >5X1R-A nrPDB Length = 302 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 45/223 (20%), Positives = 87/223 (39%), Gaps = 39/223 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK---------------------KIANAFDNKIDAKRT 107 IG+G +GIV A + + ++AIK + F +++ Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNS--F 86 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLR--NAFNDVYIAYELMDTDLHQIIRSNQ--ALSE 163 ++E +LL H ++ + LR Y+ + + +++ Q + E Sbjct: 87 IQEARLLARFSHPGLLHV-------LRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDE 139 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR--VTSESDFMT 221 + L + + IH LHRD+ N+ + + + DFG AR + + SD T Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSD-ET 198 Query: 222 EYVVTRWYRAPELLLNSSDYTAA--IDVWSVGCIFMELMDRKP 262 E V+ + E +SD D++++G + L+ P Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >4XHL-A nrPDB Length = 394 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 36/190 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK--KIAN---AFDNKIDAKRTLRE---IKLLRHMDHE 120 IG G++G + N + E VAI+ I + D + R L I +R E Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFGRE 74 Query: 121 ---NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 N + I D++ P L + FN + + + + Q+ + Sbjct: 75 GEYNAMVI-DLLGPSLEDLFNYCHRRFSFKTVIMLAL-----------------QMFCRI 116 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +YIH + +HRD+KP N L+ + + DFGL++ DF T + YR + Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK--KYRDFNTHRHIP--YRENKS 172 Query: 235 LLNSSDYTAA 244 L ++ Y + Sbjct: 173 LTGTARYASV 182 >4XHH-A nrPDB Length = 403 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 42/190 (22%), Positives = 80/190 (42%), Gaps = 36/190 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK-KIANAFDNKIDAKRTLRE-------IKLLRHMDHE 120 IG G++G + N + E VAI+ + + ++D + + + I +R E Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFIRWFGRE 74 Query: 121 ---NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 N + I D++ P L + FN + + + + Q++ + Sbjct: 75 GEYNAMVI-DLLGPSLEDLFNYCHRKFSFKTVIMLAL-----------------QMICRV 116 Query: 178 KYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +YIH + +HRD+KP N L+ + + DFGL++ DF T + YR + Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK--KYRDFNTHRHIP--YRENKS 172 Query: 235 LLNSSDYTAA 244 L ++ Y + Sbjct: 173 LTGTARYASV 182 >6J6I-B nrPDB Length = 351 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Query: 172 QILRGLKYIHSAN---VLHRDLKPSNLLLNANCDLKICD--FGLARVTSESDFMTEYVVT 226 +I + Y+H+A ++HRD+KP ++ L+ N K+ D F ++ +S E+V+ Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLG 230 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKP 262 + L + T DV+S G + ++ KP Sbjct: 231 TFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKP 266 >2CHL-A nrPDB Length = 351 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 66/151 (43%), Gaps = 16/151 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH-ENIVAIRD 127 IG G +G + N TNE VAIK K A + E + + + + I + Sbjct: 38 IGCGNFGELRLGKNLYTNEYVAIK----LEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYY 93 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSANVL 186 P NA + EL+ L + ++ S + Q++ ++Y+HS N++ Sbjct: 94 FGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLI 148 Query: 187 HRDLKPSNLLLNANCD-----LKICDFGLAR 212 +RD+KP N L+ + + I DF LA+ Sbjct: 149 YRDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 >1CSN-A nrPDB Length = 298 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 82/186 (44%), Gaps = 51/186 (27%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDA-- 104 Q N+ G ++V + IG+G++G++ N N+ VAIK F+ + DA Sbjct: 4 QNNVVGVHYKVGRR-------IGEGSFGVIFEGTNLLNNQQVAIK-----FEPRRSDAPQ 51 Query: 105 -KRTLREIKLLR---------HMDHENI--VAIRDIIPPPLRNAFNDVYIAYELMDTDLH 152 + R KLL + E + V + D++ P L +L+D Sbjct: 52 LRDEYRTYKLLAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLE----------DLLDLCGR 101 Query: 153 QIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL------NANCDLKIC 206 + A++ + Q+L ++ IH ++++RD+KP N L+ NAN + + Sbjct: 102 KFSVKTVAMAAK-------QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANM-IYVV 153 Query: 207 DFGLAR 212 DFG+ + Sbjct: 154 DFGMVK 159 >2C47-A nrPDB Length = 313 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 35/160 (21%), Positives = 66/160 (41%), Gaps = 34/160 (21%) Query: 69 IGKGAYGIVCSAMNSETNESVAIK-----------KIANAFDNKIDAKRTLREIKLLRHM 117 IG G +G + N TNE VAIK + F ++ A + ++ Sbjct: 12 IGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPC 71 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 N + + +++ P L + F+ + L + I Q++ + Sbjct: 72 GKYNAMVL-ELLGPSLEDLFDLCDRTFTLKTVLMIAI-----------------QLITRM 113 Query: 178 KYIHSANVLHRDLKPSNLLLN-----ANCDLKICDFGLAR 212 +Y+H+ ++++RD+KP N L+ + I DFGLA+ Sbjct: 114 EYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAK 153 >4IX6-A nrPDB Length = 350 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 26/113 (23%) Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEY--- 223 + ++L L +H V+HRD+KP+NL+ A D LK+ D G A + Y Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIA-AEKDGGVLKLIDLGAAALCLPLPETLNYYPG 207 Query: 224 ---VVTRWYRAPELLL-----------NSSDYTAA-----IDVWSVGCIFMEL 257 R+ +A EL L N++ A D WS GC+ ++L Sbjct: 208 DGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 >5UV4-A nrPDB Length = 311 Score = 34.7 bits (78), Expect = 0.075, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 85/207 (41%), Gaps = 15/207 (7%) Query: 65 PIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 P IG+ +G A + + +K + F K REIK L + H N+V Sbjct: 29 PAEIIGRSCHGTSYKA-TLDNGYMLTVKWLKEGFAKS--KKEFSREIKKLGSVRHPNLVP 85 Query: 125 IRDIIPPPL---RNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYI 180 +R P R +D Y + T L + N LS I R L Y+ Sbjct: 86 LRGYYWGPKEHERIMISD-YADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYL 144 Query: 181 HSANVL-HRDLKPSNLLL-NANCDLKICDFGLARVTSESDFMTEYVVTR---WYRAPELL 235 H+ V+ H ++K SN+L+ N+ + D+ L R+ + M E V+ Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIG-MAEQVLNAGALGYSPPEFS 203 Query: 236 LNSSDY-TAAIDVWSVGCIFMELMDRK 261 S + DV++ G I +EL+ K Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGK 230 >3ENH-A nrPDB Length = 540 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 23/109 (21%) Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTR-- 227 Y+I + +H +V+H DL SN + + DL I DFGL ++++ + D + +V + Sbjct: 438 YKIGEIVGKLHKNDVIHNDLTTSNFIFDK--DLYIIDFGLGKISNLDEDKAVDLIVFKKA 495 Query: 228 ------------WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 W R E Y + D W + M+ ++R+ + Sbjct: 496 VLSTHHEKFDEIWERFLE------GYKSVYDRWEIILELMKDVERRARY 538 >5UU1-A nrPDB Length = 324 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 2/73 (2%) Query: 141 YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-A 199 ++ E + DL +I N + ++L L+YIH +H D+K +NLLL Sbjct: 107 FMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYK 166 Query: 200 NCD-LKICDFGLA 211 N D + + D+GL+ Sbjct: 167 NPDQVYLADYGLS 179 >5UQL-A nrPDB Length = 558 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 77/185 (41%), Gaps = 24/185 (12%) Query: 204 KICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL 263 ++ D L + +D EY + WY + L+N+ AI V S ++L++ + Sbjct: 105 EVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNT--LKKAI-VESSTTEALQLLEEEIQ 161 Query: 264 FPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 P D++ + + +EF+ + KR+I Y + I PTV P D Sbjct: 162 NPQFDNMKFYK-----------KRMEFIYDRQKRFIN----YYKSQINK--PTV-PTIDD 203 Query: 324 LIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIY 383 +I+ L + R TVL++ NSL I+ I N F L +EL+ Sbjct: 204 IIKSHLVSEYNRDETVLESYR---TNSLRKINSNHGIDIRANSLFTEQELLNIYSQELLN 260 Query: 384 REALA 388 R LA Sbjct: 261 RGNLA 265 >5OAT-A nrPDB Length = 411 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 64/253 (25%), Positives = 106/253 (41%), Gaps = 67/253 (26%) Query: 68 PIGKGAYGIVCSAM--NSETNES---VAIKKIANAFDNKIDAKRTLR------------- 109 PI KG G+V SA + ET+++ A+K + N +D + ++ L+ Sbjct: 18 PIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFN-YDIQENSMEILKAMYRETVPARMYY 76 Query: 110 --------EIKLL---RHMD-HENIVAIRDI--------IPPPL------RNAFNDVYIA 143 EI+L +H+ H NIVAI + +PP L RN +++ Sbjct: 77 SNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM--SLFLL 134 Query: 144 YELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD- 202 + D +L + + A S L Q+L G+ ++ + + HRDLK NLLL+ + Sbjct: 135 MKRYDCNLQSFLST--APSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPE 192 Query: 203 ---LKICDFGLARVTSESDFMTEYVVTRWYR-------APELLLNSS------DYTAAID 246 L I DFG + Y + APE++ +Y+ A D Sbjct: 193 SPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKA-D 251 Query: 247 VWSVGCIFMELMD 259 +W+VG I E+ + Sbjct: 252 LWAVGAIAYEIFN 264 >6G4J-A nrPDB Length = 315 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 50/221 (22%), Positives = 85/221 (38%), Gaps = 31/221 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +GKGA GIV A ET++ K+++ D+ E+ +L+ V + Sbjct: 34 LGKGANGIVYLA---ETSDGHVALKVSD------DSLSITSEVNVLKSFSKAQSVTM--- 81 Query: 129 IPPPLRNAFNDVYI----------AYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 P +D YI A E + L +++ E + Q+L L Sbjct: 82 --GPSFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKGAEWIPVLMIQLLSSLS 137 Query: 179 YIHSANVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN 237 +H + DLKP NL++ ++ D G T E + EY T +Y Sbjct: 138 VLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG--GTTKEGRAIKEY--TEFYDRGYWGYG 193 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 + + D+++V I + + +K QLR L+E Sbjct: 194 TRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE 234 >4CI6-B nrPDB Length = 643 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 21/92 (22%), Positives = 46/92 (50%), Gaps = 7/92 (7%) Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGL-ARVTSESDFMTEY 223 ++ +++L ++ A ++H D+KP N++ + A+ + + D GL +R + TE Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES 217 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFM 255 ++APEL + + + DV+ V + Sbjct: 218 -----FKAPELGVGNLGASEKSDVFLVVSTLL 244 >4AZV-A nrPDB Length = 569 Score = 31.2 bits (69), Expect = 0.91, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 1/49 (2%) Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 L +LR L + H D++P N++++A ++ DFG + VT+ D Sbjct: 345 LGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG-SIVTTPQD 392 >2KC5-A nrPDB Length = 162 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 P + + SD+T W+ GC+ M +FPG D + LR + E IG Sbjct: 36 PSMPVYVSDFTLFEGQWT-GCVITPWMLSAVIFPGPDQLWPLRKVSEKIG 84 >6FRK-r nrPDB Length = 605 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 18/123 (14%) Query: 72 GAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPP 131 G+ G+ A+ SE N + D R L+ + + ++ +++ A+ + Sbjct: 5 GSGGVSVPALWSEVNR----------YGQNGDFTRALKTVNKILQINKDDVTALHCKVVC 54 Query: 132 PLRN-AFNDVYIAYELMDTDLHQIIRSNQALSEE--HCQYFLYQILRGLKYIHSANVLHR 188 ++N +F + A +++T H + +N +LS E +C+Y L +I LK I SAN Sbjct: 55 LIQNGSFKE---ALNVINT--HTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTD 109 Query: 189 DLK 191 LK Sbjct: 110 KLK 112 >4AZW-A nrPDB Length = 471 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 1/49 (2%) Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 L +LR L + H D++P N++++A ++ DFG + VT+ D Sbjct: 345 LGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG-SIVTTPQD 392 >5X18-A nrPDB Length = 295 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 36/166 (21%), Positives = 72/166 (43%), Gaps = 46/166 (27%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLRHMDH-------- 119 IG+G++G++ N VAIK F+ K +A + E K + ++ Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIK-----FEPRKTEAPQLRDEYKTYKILNGTPNIPYAY 69 Query: 120 -------ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 NI+ I D++ P L + F+ + S + Q Sbjct: 70 YFGQEGLHNILVI-DLLGPSLEDLFD-----------------WCGRKFSVKTVVQVAVQ 111 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLL------NANCDLKICDFGLAR 212 ++ ++ +H+ ++++RD+KP N L+ +AN ++ + DFG+A+ Sbjct: 112 MITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDAN-NIHLIDFGMAK 156 >6EWX-A nrPDB Length = 484 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 23/42 (54%) Query: 156 RSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 R+ + E + L Q+ GL+++ ++HRDL NLLL Sbjct: 202 RAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >5VE6-A nrPDB Length = 492 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLK 204 + L Q+ GL+++ ++HRDL NLLL +C L+ Sbjct: 212 FLLLQLCNGLEHLKEHGIIHRDLCLENLLL-VHCTLQ 247 >5BX9-A nrPDB Length = 416 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 6/41 (14%) Query: 338 TVLDALAHPYLNSL------HDISDEPECTIPFNFDFENHA 372 T+ DAL H + SL H + PE P+N DF +HA Sbjct: 191 TMFDALGHLGVESLGTIATYHPYTQLPEGNYPWNLDFVSHA 231 >5WRW-A nrPDB Length = 163 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 58/124 (46%), Gaps = 18/124 (14%) Query: 72 GAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPP 131 G+ G+ A+ SE N + D R L+ + + ++ +++ A+ + Sbjct: 5 GSGGVSVPALWSEVNR----------YGQNGDFTRALKTVNKILQINKDDVTALHCKVVC 54 Query: 132 PLRN-AFNDVYIAYELMDTDLHQIIRSNQALSEE--HCQYFLYQILRGLKYIHSANVLHR 188 ++N +F + A +++T H + +N +LS E +C+Y L +I LK I SAN Sbjct: 55 LIQNGSFKE---ALNVINT--HTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTD 109 Query: 189 DLKP 192 LK Sbjct: 110 KLKE 113 >4O1O-A nrPDB Length = 717 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 11/46 (23%), Positives = 25/46 (54%) Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 208 +E + L + + + +H + H+DL+P N+L+++ + DF Sbjct: 441 DESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5USZ-A nrPDB Length = 289 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 20/94 (21%), Positives = 39/94 (41%), Gaps = 11/94 (11%) Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCD--------LKICDFGLARVTSESDFMTEY 223 Q+ + ++ ++H ++ N+LL D +K+ D G++ D + E Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 + + PE + N + A D WS G E+ Sbjct: 181 IP---WVPPECIENPKNLNLATDKWSFGTTLWEI 211 >6EQI-C nrPDB Length = 433 Score = 27.7 bits (60), Expect = 8.3, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 19/94 (20%) Query: 184 NVLHRDLKPSNLLL-----NANCDLKICDFGLARVTSESDFMTEYVV-------TRWYRA 231 N+ HRDLK N+L+ +A + I DFG ++ + Y R A Sbjct: 187 NISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMA 246 Query: 232 PEL------LLNSSDYTAAIDVWSVGCIFMELMD 259 PE+ + +Y + D+W+VG I E+ + Sbjct: 247 PEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFN 279 >4OAU-C nrPDB Length = 699 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 13/47 (27%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Query: 163 EEHCQYFLYQILRGLKYIH-SANVLHRDLKPSNLLLNANCDLKICDF 208 +E + L I + ++ +H S H+DL+P N+L+++ + DF Sbjct: 438 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6DTL-A nrPDB 531 e-151 3OHT-A nrPDB 402 e-112 4EWQ-A nrPDB 397 e-111 4IC8-A nrPDB 388 e-108 5Z33-A nrPDB 387 e-108 5NGU-A nrPDB 387 e-108 1CM8-A nrPDB 387 e-108 4MYG-A nrPDB 386 e-108 4QTB-A nrPDB 385 e-107 3GC9-A nrPDB 382 e-106 4ZSG-A nrPDB 380 e-106 2F9G-A nrPDB 368 e-102 1JNK-A nrPDB 358 2e-99 5AWM-A nrPDB 358 3e-99 4QNY-A nrPDB 356 9e-99 3E7O-A nrPDB 355 1e-98 2XS0-A nrPDB 355 2e-98 4O2Z-A nrPDB 353 6e-98 3FI2-A nrPDB 343 6e-95 3RP9-A nrPDB 338 3e-93 3OZ6-A nrPDB 331 3e-91 2BPM-A nrPDB 331 3e-91 3PG1-A nrPDB 324 4e-89 3N9X-A nrPDB 323 9e-89 5JN2-A nrPDB 322 2e-88 3NIZ-A nrPDB 320 5e-88 6GU6-A nrPDB 316 7e-87 3NIE-A nrPDB 315 3e-86 4AGU-A nrPDB 309 2e-84 1G3N-A nrPDB 307 5e-84 4KRC-A nrPDB 303 6e-83 1V0B-A nrPDB 302 2e-82 4AU8-A nrPDB 301 3e-82 4BBM-A nrPDB 301 3e-82 3NCG-A nrPDB 301 3e-82 3MA6-A nrPDB 301 4e-82 5EFQ-A nrPDB 300 6e-82 3DFA-A nrPDB 299 1e-81 4MVF-A nrPDB 297 6e-81 1UA2-A nrPDB 296 7e-81 4NST-A nrPDB 296 9e-81 2I6L-A nrPDB 291 2e-79 2W96-B nrPDB 291 3e-79 5G6V-A nrPDB 290 6e-79 3LIJ-A nrPDB 289 1e-78 3MN3-A nrPDB 288 3e-78 4YZB-A nrPDB 286 8e-78 4REW-A nrPDB 286 1e-77 4CFF-A nrPDB 286 1e-77 3MIA-A nrPDB 285 2e-77 5EZV-A nrPDB 285 2e-77 2BDW-A nrPDB 285 3e-77 2VN9-A nrPDB 284 4e-77 3HZT-A nrPDB 284 6e-77 3DXN-A nrPDB 283 8e-77 4CFH-A nrPDB 282 2e-76 4RED-A nrPDB 281 2e-76 4BGQ-A nrPDB 281 3e-76 5YKS-A nrPDB 281 4e-76 5U6Y-A nrPDB 280 6e-76 5AIR-A nrPDB 280 7e-76 2QNJ-A nrPDB 280 7e-76 3H4J-B nrPDB 280 9e-76 2V7O-A nrPDB 279 1e-75 2VZ6-A nrPDB 279 2e-75 4RGJ-A nrPDB 278 2e-75 3KK8-A nrPDB 278 3e-75 5FG8-A nrPDB 278 3e-75 3BHH-A nrPDB 277 7e-75 5IG1-A nrPDB 276 8e-75 5ES1-A nrPDB 276 9e-75 4E7W-A nrPDB 276 1e-74 3SOA-A nrPDB 274 3e-74 3GC0-A nrPDB 274 4e-74 3ZDU-A nrPDB 274 4e-74 5KZ7-A nrPDB 273 9e-74 2JC6-A nrPDB 272 2e-73 2YZA-A nrPDB 268 3e-72 4FG9-A nrPDB 268 3e-72 3E3P-A nrPDB 268 3e-72 3Q5I-A nrPDB 268 3e-72 2YCR-A nrPDB 268 4e-72 4FIE-A nrPDB 268 4e-72 4JDH-A nrPDB 267 7e-72 3I6U-A nrPDB 266 1e-71 5KCV-A nrPDB 266 1e-71 4CQG-A nrPDB 264 3e-71 3F3Z-A nrPDB 263 1e-70 4D2V-A nrPDB 263 1e-70 2J90-A nrPDB 261 3e-70 2JAM-A nrPDB 261 3e-70 3COM-A nrPDB 260 8e-70 3EB0-A nrPDB 259 1e-69 3GUB-A nrPDB 259 2e-69 2YAB-A nrPDB 258 3e-69 6C9D-A nrPDB 258 4e-69 2HAK-A nrPDB 258 4e-69 2F57-A nrPDB 257 6e-69 2Y7J-A nrPDB 257 8e-69 2W4O-A nrPDB 256 9e-69 5XZW-A nrPDB 256 9e-69 5WAX-A nrPDB 256 1e-68 1PHK-A nrPDB 256 2e-68 5Y86-A nrPDB 255 2e-68 2A27-A nrPDB 255 3e-68 4LG4-A nrPDB 255 3e-68 3DB8-A nrPDB 254 3e-68 1ZWS-A nrPDB 253 8e-68 5JZN-A nrPDB 253 1e-67 4XBR-A nrPDB 253 1e-67 6AO5-A nrPDB 253 1e-67 2Q0N-A nrPDB 252 2e-67 4D28-A nrPDB 252 3e-67 6FDY-U nrPDB 251 3e-67 3TAC-A nrPDB 251 3e-67 2OU7-A nrPDB 251 3e-67 6FD3-A nrPDB 251 4e-67 4NIF-A nrPDB 251 4e-67 4CZT-A nrPDB 251 5e-67 4KS7-A nrPDB 250 9e-67 5J5T-A nrPDB 250 9e-67 5ZTN-A nrPDB 249 1e-66 4PDS-A nrPDB 249 2e-66 2HW6-A nrPDB 249 2e-66 3ZUT-A nrPDB 248 5e-66 2JDO-A nrPDB 247 7e-66 3UC3-A nrPDB 247 7e-66 3D2K-A nrPDB 247 7e-66 4B6L-A nrPDB 246 9e-66 2X4F-A nrPDB 246 9e-66 3IS5-A nrPDB 246 1e-65 3KN6-A nrPDB 246 1e-65 3MV5-A nrPDB 246 2e-65 4UZD-A nrPDB 245 2e-65 4JG6-A nrPDB 245 2e-65 4J52-A nrPDB 244 5e-65 3UDB-A nrPDB 244 6e-65 1NY3-A nrPDB 243 1e-64 3KA0-A nrPDB 243 2e-64 4JXF-A nrPDB 242 2e-64 2OZA-A nrPDB 242 2e-64 3Q53-A nrPDB 241 3e-64 3FXW-A nrPDB 240 7e-64 5D9K-A nrPDB 240 9e-64 4YNZ-A nrPDB 239 1e-63 6CMJ-A nrPDB 239 1e-63 1KOB-A nrPDB 238 2e-63 6CKI-A nrPDB 238 3e-63 2XIK-A nrPDB 238 3e-63 4QMW-A nrPDB 238 4e-63 5F9E-A nrPDB 236 1e-62 3ALO-A nrPDB 236 1e-62 2UV2-A nrPDB 236 1e-62 1FOT-A nrPDB 235 2e-62 4FZF-B nrPDB 235 2e-62 4L42-A nrPDB 235 2e-62 2Z7Q-A nrPDB 235 3e-62 3HDN-A nrPDB 235 3e-62 3DAK-A nrPDB 235 3e-62 4I6B-A nrPDB 235 3e-62 5YV8-A nrPDB 234 5e-62 3VN9-A nrPDB 234 6e-62 6O6Q-A nrPDB 234 7e-62 3HKO-A nrPDB 233 8e-62 6FYV-A nrPDB 233 9e-62 5X8I-B nrPDB 233 1e-61 3UTO-A nrPDB 233 1e-61 4RLP-A nrPDB 233 1e-61 5DBX-A nrPDB 232 1e-61 1VZO-A nrPDB 232 2e-61 3LM0-A nrPDB 232 2e-61 3A8W-A nrPDB 232 3e-61 1U5R-A nrPDB 231 3e-61 1KOA-A nrPDB 231 5e-61 5D7A-A nrPDB 231 5e-61 2GCD-A nrPDB 231 6e-61 3ORZ-A nrPDB 230 1e-60 3TXO-A nrPDB 229 1e-60 6HXF-B nrPDB 228 3e-60 6QAU-A nrPDB 228 4e-60 4WNO-A nrPDB 228 4e-60 4CSV-A nrPDB 227 4e-60 4RA4-A nrPDB 227 5e-60 5X3F-B nrPDB 227 6e-60 4CRL-A nrPDB 227 7e-60 4B8L-A nrPDB 225 2e-59 2PVN-A nrPDB 225 3e-59 4WB7-A nrPDB 224 5e-59 4MD7-E nrPDB 224 5e-59 3NYO-A nrPDB 224 5e-59 5N23-A nrPDB 224 5e-59 4APC-A nrPDB 223 9e-59 6BDL-A nrPDB 223 1e-58 5DYK-A nrPDB 222 2e-58 3FME-A nrPDB 222 2e-58 6EII-A nrPDB 222 2e-58 3RAW-A nrPDB 221 5e-58 6CQF-A nrPDB 221 6e-58 2WO6-A nrPDB 220 7e-58 5FET-A nrPDB 220 7e-58 4FR4-A nrPDB 220 1e-57 2BRG-A nrPDB 220 1e-57 5XVU-A nrPDB 219 1e-57 4C0T-A nrPDB 219 1e-57 4AF3-A nrPDB 219 2e-57 6HMD-A nrPDB 219 2e-57 5LOH-A nrPDB 219 2e-57 4TNB-A nrPDB 219 2e-57 2WTK-C nrPDB 219 2e-57 2H8H-A nrPDB 217 6e-57 6F3F-A nrPDB 217 8e-57 4U41-A nrPDB 216 1e-56 5O2B-A nrPDB 216 1e-56 4PWN-A nrPDB 216 1e-56 3PFQ-A nrPDB 215 2e-56 5O2C-A nrPDB 215 3e-56 6CCF-A nrPDB 214 4e-56 6ED6-A nrPDB 214 5e-56 5SYS-A nrPDB 214 7e-56 6E9W-A nrPDB 213 9e-56 2I0E-A nrPDB 213 1e-55 1TKI-A nrPDB 212 2e-55 3TKU-A nrPDB 212 2e-55 4EBW-A nrPDB 211 4e-55 5VO2-A nrPDB 211 4e-55 2DQ7-X nrPDB 211 5e-55 2FO0-A nrPDB 211 6e-55 4XEY-B nrPDB 211 6e-55 5UNP-A nrPDB 211 7e-55 4KIK-B nrPDB 210 8e-55 3C51-A nrPDB 209 1e-54 6E2O-A nrPDB 209 1e-54 3M42-A nrPDB 209 2e-54 4IAN-A nrPDB 209 2e-54 2XNP-A nrPDB 208 3e-54 6NPU-A nrPDB 208 4e-54 3QA8-A nrPDB 208 4e-54 4AW2-A nrPDB 208 4e-54 2J0K-A nrPDB 208 4e-54 2WQN-A nrPDB 207 6e-54 3PPZ-A nrPDB 207 6e-54 4XLV-A nrPDB 206 1e-53 4OLI-A nrPDB 206 1e-53 4GS6-A nrPDB 206 1e-53 5UUU-A nrPDB 206 1e-53 6DBM-A nrPDB 206 2e-53 2XYN-A nrPDB 206 2e-53 4YHJ-A nrPDB 206 2e-53 4C59-A nrPDB 205 2e-53 4IDT-A nrPDB 205 2e-53 6GVJ-A nrPDB 205 3e-53 4E93-A nrPDB 205 3e-53 5TQX-A nrPDB 205 3e-53 3PVW-A nrPDB 205 4e-53 5KKR-C nrPDB 204 4e-53 3EQC-A nrPDB 204 4e-53 3A4O-X nrPDB 204 4e-53 5H2U-A nrPDB 204 6e-53 6DBN-A nrPDB 203 1e-52 4E20-A nrPDB 203 1e-52 3DLS-A nrPDB 202 2e-52 4EQM-A nrPDB 202 3e-52 4OTD-A nrPDB 202 3e-52 2X7G-A nrPDB 201 4e-52 4XCU-A nrPDB 201 4e-52 5X5O-A nrPDB 201 5e-52 4AN9-A nrPDB 201 5e-52 4UY9-A nrPDB 201 5e-52 5AP3-A nrPDB 201 6e-52 4LFI-A nrPDB 200 8e-52 1JPA-A nrPDB 200 9e-52 5MJB-A nrPDB 199 1e-51 6BXI-A nrPDB 199 2e-51 5B2L-A nrPDB 199 2e-51 2Y6O-A nrPDB 199 2e-51 4CRS-A nrPDB 199 2e-51 3HMP-A nrPDB 199 2e-51 4WUA-A nrPDB 199 2e-51 3OMV-A nrPDB 199 2e-51 6GQK-A nrPDB 198 3e-51 4XI2-A nrPDB 198 3e-51 3TT0-A nrPDB 198 3e-51 1ZXE-A nrPDB 198 4e-51 4H1J-A nrPDB 198 4e-51 3V5Q-A nrPDB 198 4e-51 2HK5-A nrPDB 198 4e-51 2JD5-A nrPDB 198 4e-51 1K9A-A nrPDB 197 5e-51 2R2P-A nrPDB 197 5e-51 4P5Q-A nrPDB 197 5e-51 3LLT-A nrPDB 197 7e-51 3DTC-A nrPDB 197 7e-51 5L6P-A nrPDB 197 8e-51 2VWV-A nrPDB 197 9e-51 5A46-A nrPDB 197 1e-50 3QGY-A nrPDB 196 1e-50 5HI2-A nrPDB 196 1e-50 3GQL-A nrPDB 196 1e-50 1S9I-A nrPDB 196 1e-50 2VD5-A nrPDB 196 2e-50 2ZMD-A nrPDB 196 2e-50 3DKO-A nrPDB 196 2e-50 5HIE-A nrPDB 196 2e-50 2W1I-A nrPDB 195 3e-50 4Y93-A nrPDB 195 3e-50 5O0Y-A nrPDB 194 4e-50 3IO7-A nrPDB 194 4e-50 2PL0-A nrPDB 194 5e-50 4AT3-A nrPDB 194 6e-50 6E4F-A nrPDB 194 6e-50 4UYA-A nrPDB 194 8e-50 4K33-A nrPDB 194 8e-50 3I81-A nrPDB 193 1e-49 1BYG-A nrPDB 193 1e-49 3CJF-A nrPDB 192 1e-49 4PDO-A nrPDB 192 2e-49 2PSQ-A nrPDB 192 3e-49 3QUP-A nrPDB 191 4e-49 5U6B-A nrPDB 191 4e-49 4M7I-A nrPDB 191 5e-49 2A1A-B nrPDB 190 6e-49 5KMM-A nrPDB 190 8e-49 1AD5-A nrPDB 190 9e-49 3BGP-A nrPDB 189 1e-48 4XUF-A nrPDB 189 1e-48 2OGV-A nrPDB 189 1e-48 5TUR-A nrPDB 189 2e-48 3SXS-A nrPDB 189 2e-48 3ORP-A nrPDB 189 2e-48 4HVI-A nrPDB 188 3e-48 5HVK-A nrPDB 188 3e-48 6FEX-A nrPDB 188 4e-48 5EG3-A nrPDB 188 4e-48 4RC3-A nrPDB 188 4e-48 5X02-A nrPDB 188 4e-48 3KRL-A nrPDB 187 5e-48 3KUL-B nrPDB 187 7e-48 5TOS-A nrPDB 187 7e-48 5UIU-A nrPDB 187 8e-48 3BEA-A nrPDB 187 8e-48 3UIU-A nrPDB 187 1e-47 3BBT-B nrPDB 186 1e-47 2OZO-A nrPDB 186 2e-47 1U59-A nrPDB 186 2e-47 6BSD-A nrPDB 186 2e-47 4TPT-A nrPDB 186 2e-47 1LUF-A nrPDB 185 2e-47 5WNL-A nrPDB 185 2e-47 4R7H-A nrPDB 185 3e-47 4YFF-A nrPDB 185 3e-47 6FER-A nrPDB 185 4e-47 4X3F-A nrPDB 184 5e-47 4OW8-A nrPDB 184 6e-47 2WTK-B nrPDB 184 6e-47 6B2Q-A nrPDB 184 6e-47 3G0E-A nrPDB 183 1e-46 5GRN-A nrPDB 183 1e-46 4X7Q-B nrPDB 182 2e-46 1FVR-A nrPDB 182 2e-46 6CTH-A nrPDB 182 2e-46 4HZS-A nrPDB 182 2e-46 5AMN-A nrPDB 182 2e-46 4G3E-A nrPDB 182 2e-46 5U6C-A nrPDB 182 3e-46 3ZBF-A nrPDB 182 3e-46 5VD3-A nrPDB 182 3e-46 3PLS-A nrPDB 181 3e-46 3LZB-A nrPDB 181 5e-46 4Y83-A nrPDB 180 6e-46 5GNK-A nrPDB 180 7e-46 1U54-B nrPDB 180 7e-46 3PP0-A nrPDB 180 8e-46 5HLW-A nrPDB 180 1e-45 5FM2-A nrPDB 179 3e-45 4NEU-A nrPDB 177 5e-45 4PL5-B nrPDB 177 1e-44 5LPZ-A nrPDB 176 1e-44 2RIO-A nrPDB 176 1e-44 6HV0-A nrPDB 176 1e-44 5LPV-A nrPDB 176 1e-44 3C1X-A nrPDB 176 1e-44 6J5U-C nrPDB 176 2e-44 2BUJ-A nrPDB 175 3e-44 2PMN-X nrPDB 175 4e-44 4LRM-A nrPDB 174 6e-44 3Q4U-A nrPDB 174 6e-44 3QD2-B nrPDB 173 1e-43 4JLC-A nrPDB 172 3e-43 6DC0-A nrPDB 171 6e-43 5CEK-A nrPDB 170 7e-43 4EUU-A nrPDB 170 7e-43 3UIM-A nrPDB 170 9e-43 4FL3-A nrPDB 170 9e-43 4EUT-A nrPDB 169 2e-42 3MDY-A nrPDB 169 3e-42 6O8B-A nrPDB 168 3e-42 3SOC-A nrPDB 168 4e-42 4F0G-A nrPDB 168 5e-42 3ZZW-A nrPDB 167 5e-42 6NT9-A nrPDB 167 7e-42 5WNO-A nrPDB 167 8e-42 3MY0-A nrPDB 166 1e-41 5TE0-A nrPDB 166 1e-41 5C26-A nrPDB 166 2e-41 5IKW-A nrPDB 162 2e-40 1PY5-A nrPDB 161 5e-40 4M66-A nrPDB 160 7e-40 5XD6-A nrPDB 160 7e-40 3G2F-A nrPDB 159 1e-39 5AR8-A nrPDB 159 2e-39 2QKW-B nrPDB 158 3e-39 2Y4I-B nrPDB 158 3e-39 4F9B-A nrPDB 157 9e-39 2H34-A nrPDB 157 1e-38 2QLU-A nrPDB 157 1e-38 3LMG-A nrPDB 156 1e-38 5VC6-A nrPDB 156 2e-38 5VDK-A nrPDB 155 4e-38 5J0A-A nrPDB 153 2e-37 6BFN-A nrPDB 150 8e-37 5L2Q-C nrPDB 149 2e-36 5E8V-A nrPDB 148 4e-36 4LQP-A nrPDB 145 2e-35 4M69-B nrPDB 140 1e-33 4BTF-A nrPDB 140 1e-33 4JRN-A nrPDB 139 2e-33 3HNG-A nrPDB 134 6e-32 4BTK-A nrPDB 132 2e-31 3VHK-A nrPDB 131 6e-31 4NFN-A nrPDB 130 1e-30 5FQD-C nrPDB 129 3e-30 2PZI-A nrPDB 128 3e-30 4Y12-A nrPDB 128 4e-30 4RT7-A nrPDB 122 4e-28 3SV0-A nrPDB 120 1e-27 4L68-A nrPDB 118 3e-27 4TN6-A nrPDB 116 2e-26 2CMW-A nrPDB 110 1e-24 Sequences not found previously or not previously below threshold: 3AOX-A nrPDB 176 1e-44 4MWI-A nrPDB 135 5e-32 5USZ-A nrPDB 119 2e-27 4L00-A nrPDB 114 7e-26 5X1R-A nrPDB 110 8e-25 5UV4-A nrPDB 109 3e-24 2CHL-A nrPDB 108 3e-24 5X18-A nrPDB 107 1e-23 5M07-A nrPDB 106 2e-23 3REP-A nrPDB 106 2e-23 2C47-A nrPDB 105 3e-23 5OAT-A nrPDB 105 4e-23 4NT4-A nrPDB 105 5e-23 4I94-A nrPDB 98 6e-21 6EQI-C nrPDB 96 2e-20 1CSN-A nrPDB 96 2e-20 6J6I-B nrPDB 95 4e-20 4XHH-A nrPDB 94 8e-20 4XHL-A nrPDB 94 1e-19 5C01-A nrPDB 93 2e-19 4WOV-A nrPDB 93 3e-19 4IX6-A nrPDB 79 3e-15 5CLR-A nrPDB 77 2e-14 5UU1-A nrPDB 75 4e-14 2RSV-A nrPDB 75 7e-14 4CI6-B nrPDB 72 3e-13 2LAV-A nrPDB 72 5e-13 4O1O-A nrPDB 67 2e-11 4OAU-C nrPDB 66 2e-11 6G4J-A nrPDB 66 2e-11 5DMZ-A nrPDB 66 2e-11 6EAS-A nrPDB 66 3e-11 6M7Z-A nrPDB 63 2e-10 6EWX-A nrPDB 62 5e-10 4CYJ-A nrPDB 60 1e-09 6BHC-A nrPDB 59 3e-09 5GZ9-A nrPDB 57 1e-08 2JII-A nrPDB 57 2e-08 5GZA-A nrPDB 55 5e-08 3ENH-A nrPDB 55 6e-08 5VE6-A nrPDB 55 8e-08 4AZV-A nrPDB 53 2e-07 4AZW-A nrPDB 53 2e-07 4CZY-B nrPDB 52 6e-07 3BYV-A nrPDB 51 9e-07 3Q60-A nrPDB 50 2e-06 4BWP-A nrPDB 49 3e-06 3DZO-A nrPDB 47 1e-05 4WWA-A nrPDB 46 2e-05 2W1Z-A nrPDB 45 4e-05 6G38-A nrPDB 44 9e-05 5YK0-A nrPDB 42 4e-04 6R5K-O nrPDB 42 5e-04 4XR7-L nrPDB 42 7e-04 1TQM-A nrPDB 38 0.010 6DFL-A nrPDB 36 0.036 6GEJ-S nrPDB 34 0.093 6G18-v nrPDB 32 0.48 4ESA-B nrPDB 32 0.52 6FDN-A nrPDB 32 0.67 4BVU-A nrPDB 31 0.93 3NPK-A nrPDB 31 1.1 >6DTL-A nrPDB Length = 364 Score = 531 bits (1367), Expect = e-151, Method: Composition-based stats. Identities = 364/364 (100%), Positives = 364/364 (100%) Query: 32 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 91 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI Sbjct: 1 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 60 Query: 92 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 151 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL Sbjct: 61 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 120 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 211 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA Sbjct: 121 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 180 Query: 212 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH Sbjct: 181 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 240 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF Sbjct: 241 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 300 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP Sbjct: 301 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 Query: 392 EYQQ 395 EYQQ Sbjct: 361 EYQQ 364 >3OHT-A nrPDB Length = 389 Score = 402 bits (1033), Expect = e-112, Method: Composition-based stats. Identities = 168/368 (45%), Positives = 236/368 (64%), Gaps = 9/368 (2%) Query: 29 QMPGIENIPATLSHGGR--FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 + G P T+SH R F + + I+EV +Y+ + P+G GAYG VCS+ + ++ Sbjct: 18 KKAGSAAAPFTMSHKERPTFYRQELNKTIWEVPERYQT-LSPVGSGAYGSVCSSYDVKSG 76 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYE 145 +A+KK++ F + I AKRT RE++LL+HM HEN++ + D+ P FNDVY+ Sbjct: 77 LKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTH 136 Query: 146 LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 LM DL+ I++ Q L+++H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI Sbjct: 137 LMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 195 Query: 206 CDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 DFGLAR D MT YV TRWYRAPE++LN Y +D+WSVGCI EL+ + LFP Sbjct: 196 LDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFP 253 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 G DH++QL+ +M L GTP + + + A+ YI LP P+++ D F +PLA+DL Sbjct: 254 GTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDL 313 Query: 325 IEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYR 384 +EKML D +RIT +ALAHPY + HD DEPE P++ FE+ L E+ K L Y Sbjct: 314 LEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPESE-PYDQSFESRQLEIEEWKRLTYE 372 Query: 385 EALAFNPE 392 E +F Sbjct: 373 EVCSFETP 380 >4EWQ-A nrPDB Length = 383 Score = 397 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 163/349 (46%), Positives = 231/349 (66%), Gaps = 7/349 (2%) Query: 46 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 105 F + + I+EV +Y+ + P+G GAYG VC+A +++T VA+KK++ F + I AK Sbjct: 31 FYRQELNKTIWEVPERYQN-LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK 89 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 RT RE++LL+HM HEN++ + D+ P FNDVY+ LM DL+ I++ Q L+++ Sbjct: 90 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKLTDD 148 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 224 H Q+ +YQILRGLKYIHSA+++HRDLKPSNL +N +C+LKI DFGLAR D MT YV Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYV 206 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 TRWYRAPE++LN Y +D+WSVGCI EL+ + LFPG DH+ QL+L++ L+GTP Sbjct: 207 ATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 266 Query: 285 EEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 E L+ + +E+A+ YI+ L P+ + + F +PLA+DL+EKML D +RIT AL Sbjct: 267 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 326 Query: 344 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPE 392 AH Y HD DEP P++ FE+ L ++ K L Y E ++F P Sbjct: 327 AHAYFAQYHDPDDEP-VADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 374 >4IC8-A nrPDB Length = 442 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 181/380 (47%), Positives = 248/380 (65%), Gaps = 9/380 (2%) Query: 23 AAAPSPQMPGIENIPATLSHGGR-FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAM 81 A P P + A+++ ++ F F+V +Y+ I IG GAYG+V SA Sbjct: 17 AEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEI-IETIGNGAYGVVSSAR 75 Query: 82 NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPL-RNAFNDV 140 T + VAIKKI NAFD +AKRTLRE+K+L+H H+NI+AI+DI+ P + F V Sbjct: 76 RRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSV 135 Query: 141 YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 Y+ +LM++DLHQII S+Q L+ EH +YFLYQ+LRGLKY+HSA V+HRDLKPSNLL+N N Sbjct: 136 YVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNEN 195 Query: 201 CDLKICDFGLARVT-----SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFM 255 C+LKI DFG+AR FMTEYV TRWYRAPEL+L+ +YT AID+WSVGCIF Sbjct: 196 CELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFG 255 Query: 256 ELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN-ENAKRYIRQLPPYPRQSITDKF 314 E++ R+ LFPG+++VHQL+L+M ++GTPS ++ + E + YI+ LPP + Sbjct: 256 EMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVY 315 Query: 315 PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALS 374 P A+ L+ +ML F+P RI+ AL HP+L HD DEP+C PF+F F+ AL+ Sbjct: 316 PGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALT 375 Query: 375 EEQMKELIYREALAFNPEYQ 394 E++KE I E F+ + Sbjct: 376 RERIKEAIVAEIEDFHARRE 395 >5Z33-A nrPDB Length = 425 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 180/348 (51%), Positives = 234/348 (67%), Gaps = 10/348 (2%) Query: 49 YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL 108 + +F F V +Y +G+GAYGIVC+A+N++T+E VAIKK+ N F KI AKR L Sbjct: 20 FKVFNQDFIVDERYTVT-KELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRAL 78 Query: 109 REIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ 167 REIKLL+H H NI + D+ P + FN+ Y+ ELM+ DL IIRS Q L++ H Q Sbjct: 79 REIKLLQHFRGHRNITCLYDM-DIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQ 137 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES-----DFMTE 222 F+YQIL GLKYIHSANVLHRDLKP NLL+NA+C+LKICDFGLAR S +MTE Sbjct: 138 SFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTE 197 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 YV TRWYRAPE++L+ YT AIDVWSVGCI EL+ +P F GRD+V QL ++ ++GT Sbjct: 198 YVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGT 257 Query: 283 PSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 341 P+EE L + + A+ Y+R LP ++ FP +P A+DL+++ML FDP RI+V Sbjct: 258 PNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQ 317 Query: 342 ALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAF 389 AL HPYL+ HD SDEP+C FNFDFE +M+++I E F Sbjct: 318 ALEHPYLHIWHDASDEPDCPTTFNFDFEVVE-DVGEMRKMILDEVYRF 364 >5NGU-A nrPDB Length = 381 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 179/349 (51%), Positives = 238/349 (68%), Gaps = 8/349 (2%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 + G +F+V +Y + IG+GAYG+VCSA ++ VAIKKI+ F+++ +RTLRE Sbjct: 33 VRGQVFDVGPRY-TNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLRE 90 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 IK+L HENI+ I DII P DVYI +LM+TDL++++++ Q LS +H YFL Sbjct: 91 IKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFL 149 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD----FMTEYVVT 226 YQILRGLKYIHSANVLHRDLKPSNLLLN CDLKICDFGLARV F+TEYV T Sbjct: 150 YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVAT 209 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 RWYRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+E Sbjct: 210 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 269 Query: 287 ELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +L + N A+ Y+ LP + FP A+DL++KMLTF+P +RI V ALAH Sbjct: 270 DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 329 Query: 346 PYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 PYL +D SDEP PF FD E L +E++KELI+ E F P Y+ Sbjct: 330 PYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 378 >1CM8-A nrPDB Length = 367 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 150/354 (42%), Positives = 225/354 (63%), Gaps = 7/354 (1%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 102 F + + +EV A Y+ + P+G GAYG VCSA++ T VAIKK+ F +++ Sbjct: 8 RSGFYRQEVTKTAWEVRAVYR-DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Query: 103 DAKRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQAL 161 AKR RE++LL+HM HEN++ + D+ P + F D Y+ M TDL ++++ ++ L Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK-HEKL 125 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT 221 E+ Q+ +YQ+L+GL+YIH+A ++HRDLKP NL +N +C+LKI DFGLAR MT Sbjct: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMT 183 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 YVVTRWYRAPE++LN YT +D+WSVGCI E++ K LF G DH+ QL+ +M++ G Sbjct: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Query: 282 TPSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 TP E ++ L ++ AK Y++ LP ++ PLA++L+EKML D +R+T Sbjct: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 Query: 341 DALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 +ALAHPY SLHD DEP+ ++ F++ + ++ K + Y+E L+F P Q Sbjct: 304 EALAHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 >4MYG-A nrPDB Length = 372 Score = 386 bits (992), Expect = e-108, Method: Composition-based stats. Identities = 154/359 (42%), Positives = 216/359 (60%), Gaps = 7/359 (1%) Query: 35 NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI 94 +L F + ++ +E+ Y P G GAYG VCSA++ + E VAIKK+ Sbjct: 18 GSHMSLIRKKGFYKQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEKVAIKKL 76 Query: 95 ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQ 153 + F ++I AKR RE+ LL+HM HEN++ + D+ P F D Y+ M TDL + Sbjct: 77 SRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQK 136 Query: 154 IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 I+ SEE QY +YQ+L+GLKYIHSA V+HRDLKP NL +N +C+LKI DFGLAR Sbjct: 137 IM--GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR- 193 Query: 214 TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 MT YVVTRWYRAPE++L+ Y +D+WSVGCI E++ K LF G+D++ QL Sbjct: 194 -HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQL 252 Query: 274 RLLMELIGTPSEEELEFLNENA-KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 ++++ G P E ++ LN+ A K YI+ LP PR+ T FP P A DL+EKML D Sbjct: 253 TQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELD 312 Query: 333 PRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 +R+T AL HP+ D +E E PF+ E+ L+ ++ K+ IY+E + F+P Sbjct: 313 VDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >4QTB-A nrPDB Length = 380 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 172/348 (49%), Positives = 239/348 (68%), Gaps = 8/348 (2%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 + G F+V +Y + IG+GAYG+V SA + VAIKKI+ F+++ +RTLRE Sbjct: 32 VKGQPFDVGPRY-TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLRE 89 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 I++L HEN++ IRDI+ A DVYI +LM+TDL+++++S Q LS +H YFL Sbjct: 90 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFL 148 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE----SDFMTEYVVT 226 YQILRGLKYIHSANVLHRDLKPSNLL+N CDLKICDFGLAR+ + F+TEYV T Sbjct: 149 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 208 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 RWYRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+E Sbjct: 209 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 268 Query: 287 ELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +L + N A+ Y++ LP + + FP A+DL+++MLTF+P +RITV +ALAH Sbjct: 269 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 328 Query: 346 PYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEY 393 PYL +D +DEP PF F E L +E++KELI++E F P Sbjct: 329 PYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGV 376 >3GC9-A nrPDB Length = 370 Score = 382 bits (982), Expect = e-106, Method: Composition-based stats. Identities = 158/351 (45%), Positives = 232/351 (66%), Gaps = 7/351 (1%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 F + + ++EV + + P+G GAYG VCSA ++ + VA+KK++ F + Sbjct: 9 GPRAGFYRQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS 67 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQIIRSNQ 159 I A+RT RE++LL+H+ HEN++ + D+ P F++VY+ LM DL+ I++S Q Sbjct: 68 LIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS-Q 126 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF 219 ALS+EH Q+ +YQ+LRGLKYIHSA ++HRDLKPSN+ +N + +L+I DFGLAR E Sbjct: 127 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE-- 184 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 MT YV TRWYRAPE++LN Y +D+WSVGCI EL+ K LFPG D++ QL+ +ME+ Sbjct: 185 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEV 244 Query: 280 IGTPSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 +GTPS E L + +E+A+ YI+ LPP P++ ++ F +PLAIDL+ +ML D +R++ Sbjct: 245 VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS 304 Query: 339 VLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAF 389 +ALAH Y + HD DEPE P++ E + E+ KEL Y+E L+F Sbjct: 305 AAEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSF 354 >4ZSG-A nrPDB Length = 347 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 176/347 (50%), Positives = 237/347 (68%), Gaps = 8/347 (2%) Query: 55 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 F+V +Y+ I IG GAYG+V SA T + VAIKKI NAFD +AKRTLRE+K+L Sbjct: 2 TFDVGDEYEI-IETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 115 RHMDHENIVAIRDIIPPPL-RNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQI 173 +H H+NI+AI+DI+ P + F VY+ +LM++DLHQII S+Q L+ EH +YFLYQ+ Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT-----SESDFMTEYVVTRW 228 LRGLKY+HSA V+HRDLKPSNLL+N NC+LKI DFG+AR FMTEYV TRW Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 YRAPEL+L+ +YT AID+WSVGCIF E++ R+ LFPG+++VHQL+L+M ++GTPS + Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 289 EFLN-ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 347 + + E + YI+ LPP +P A+ L+ +ML F+P RI+ AL HP+ Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 348 LNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 L HD DEP+C PF+F F+ AL+ E++KE I E F+ + Sbjct: 301 LAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 347 >2F9G-A nrPDB Length = 353 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 174/337 (51%), Positives = 226/337 (67%), Gaps = 19/337 (5%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 +G+GAYG+VCSA + T E VAIKKI FD + A RTLREIK+L+H HENI+ I +I Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 P FN+VYI ELM TDLH++I S Q LS++H QYF+YQ LR +K +H +NV+HR Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 189 DLKPSNLLLNANCDLKICDFGLARVTSES-----------DFMTEYVVTRWYRAPELLLN 237 DLKPSNLL+N+NCDLK+CDFGLAR+ ES MTEYV TRWYRAPE++L Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP--SEEELEFLNENA 295 S+ Y+ A+DVWS GCI EL R+P+FPGRD+ HQL L+ +IGTP + + A Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 + YI+ LP YP + FP V+P IDL+++ML FDP +RIT +AL HPYL + HD + Sbjct: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 Query: 356 DEPECTIP----FNFDFENHALSEEQMKELIYREALA 388 DEPE F FD AL+ + +K+LI+ E + Sbjct: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >1JNK-A nrPDB Length = 423 Score = 358 bits (919), Expect = 2e-99, Method: Composition-based stats. Identities = 143/359 (39%), Positives = 213/359 (59%), Gaps = 20/359 (5%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ A Sbjct: 47 QFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 KR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDH 163 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Y Sbjct: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 223 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 VVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +GTP Sbjct: 224 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTV------------HPLAIDLIEKMLTF 331 E ++ L + Y+ P Y + FP A DL+ KML Sbjct: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPECTIP--FNFDFENHALSEEQMKELIYREALA 388 DP +RI+V DAL HPY+N +D + E E P ++ + + E+ KELIY+E + Sbjct: 343 DPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >5AWM-A nrPDB Length = 394 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 142/373 (38%), Positives = 210/373 (56%), Gaps = 22/373 (5%) Query: 35 NIPATLSHGG-RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKK 93 T++ + + F + ++Y + PIG GA GIVC+A ++ T ++VAIKK Sbjct: 18 GSHRTMTTAQHQHYTVEVGDTNFTIHSRYIN-LRPIGSGAQGIVCAAYDTITQQNVAIKK 76 Query: 94 IANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLH 152 ++ F N AKR RE KL++ ++H+NI+ + + P F DVY+ ELMD +L Sbjct: 77 LSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLC 136 Query: 153 QIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 212 Q+I+ + L + Y LYQ+L G+K++HSA ++HRDLKPSN+++ A+C LKI DFGLAR Sbjct: 137 QVIQMD--LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR 194 Query: 213 VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 + MT YVVTR+YRAPE++L YT +D+WSVGCI E++ LFPG DH+ Q Sbjct: 195 TAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQ 253 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFP-------------TVHP 319 ++E +GTPS ++ L + Y+ P Y S FP Sbjct: 254 WNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKAS 313 Query: 320 LAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS--DEPECTIPFNFDFENHALSEEQ 377 A +L+ KML DP +RI+V +AL H Y+N +D D P P++ + + EQ Sbjct: 314 DARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAP-APEPYDHSVDEREHTVEQ 372 Query: 378 MKELIYREALAFN 390 KELIY E + + Sbjct: 373 WKELIYEEVMDYE 385 >4QNY-A nrPDB Length = 354 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 156/362 (43%), Positives = 230/362 (63%), Gaps = 12/362 (3%) Query: 35 NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMN-SETNESVAIKK 93 +PAT S + + + +Y IG G+YG+V A + N VA+K+ Sbjct: 1 GMPATKSLA------ELQAEVCRLDDRYLLE-RIIGAGSYGVVIRARDTKSDNRLVAMKR 53 Query: 94 I-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLH 152 + F+ I AKR LREIKLL H + +NI+ +R+I+ P F+ YI ++M+TDL Sbjct: 54 VNKEIFEEVILAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLK 113 Query: 153 QIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 212 Q++RS Q L+E H Q+F+YQ LR L IHSA V+HRD+ P+N+L+N NCDLKICDFGLA+ Sbjct: 114 QVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK 173 Query: 213 -VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 + ++MT+YV RWYRAPEL++ DY+A IDVW +GCI EL+ +PLF G+D V+ Sbjct: 174 EENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVN 233 Query: 272 QLRLLMELIGTPSEEELEFL-NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 QL ++++IGTPSEE++ + + A++Y+++ P+ ++PT P A+DL+ ML Sbjct: 234 QLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLV 293 Query: 331 FDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 F+P+RRITVL A+ HP+L LHD +D+ F FD EN + +K IY E++ F+ Sbjct: 294 FNPKRRITVLQAMRHPFLEQLHDDADDNLSYALFRFD-ENEQKTIVDVKRAIYEESVKFH 352 Query: 391 PE 392 E Sbjct: 353 NE 354 >3E7O-A nrPDB Length = 360 Score = 355 bits (912), Expect = 1e-98, Method: Composition-based stats. Identities = 141/361 (39%), Positives = 211/361 (58%), Gaps = 20/361 (5%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 102 +F + + F V +Y+ + PIG GA GIVC+A ++ +VA+KK++ F N+ Sbjct: 5 DSQFYSVQVADSTFTVLKRYQQ-LKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQT 63 Query: 103 DAKRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQAL 161 AKR RE+ LL+ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I + L Sbjct: 64 HAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--HMEL 121 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT 221 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S + MT Sbjct: 122 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMT 181 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 YVVTR+YRAPE++L Y +D+WSVGCI EL+ +F G DH+ Q ++E +G Sbjct: 182 PYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLG 240 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPT------------VHPLAIDLIEKML 329 TPS E + L + Y+ P YP + + FP A DL+ KML Sbjct: 241 TPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKML 300 Query: 330 TFDPRRRITVLDALAHPYLNSLHDISDEPECTIP--FNFDFENHALSEEQMKELIYREAL 387 DP +RI+V +AL HPY+ +D ++ E P ++ E + E+ KELIY+E + Sbjct: 301 VIDPDKRISVDEALRHPYITVWYDPAEA-EAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 Query: 388 A 388 Sbjct: 360 D 360 >2XS0-A nrPDB Length = 386 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 145/369 (39%), Positives = 211/369 (57%), Gaps = 23/369 (6%) Query: 38 ATLSHGGR---FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI 94 ++S R F I + F V +Y+ + PIG GA GIVC+A ++ +VAIKK+ Sbjct: 1 GSMSRSKRDNNFYSVEIGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAILERNVAIKKL 59 Query: 95 ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR-NAFNDVYIAYELMDTDLHQ 153 + F N+ AKR RE+ L++ ++H+NI+ + ++ P F DVYI ELMD +L Q Sbjct: 60 SRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQ 119 Query: 154 IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 +I+ L E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR Sbjct: 120 VIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART 177 Query: 214 TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 S M +VVTR+YRAPE++L Y +D+WSVGCI E++ LFPG DH+ Q Sbjct: 178 AGTSFMMVPFVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQW 236 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTV------------HPLA 321 ++E +GTP E ++ L + Y+ P Y S FP V A Sbjct: 237 NKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQA 296 Query: 322 IDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS--DEPECTIPFNFDFENHALSEEQMK 379 DL+ KML D +RI+V +AL HPY+N +D S + P IP + + + E+ K Sbjct: 297 RDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIP-DKQLDEREHTIEEWK 355 Query: 380 ELIYREALA 388 ELIY+E + Sbjct: 356 ELIYKEVMD 364 >4O2Z-A nrPDB Length = 377 Score = 353 bits (907), Expect = 6e-98, Method: Composition-based stats. Identities = 160/353 (45%), Positives = 227/353 (64%), Gaps = 9/353 (2%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 G F YN+ G+ FEV +KY + +G GAYGI CS ++ +T E V+IKK + F + D Sbjct: 29 GDFKVYNVSGSPFEVPSKY-TLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVED 87 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLR--NAFNDVYIAYELMDTDLHQIIRSNQAL 161 KR LREI ++R HEN++ + +I+PP R ++F DVY+ LMD D++ ++RS Q L Sbjct: 88 GKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVL 147 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFM 220 E H QYF+YQILRGLKY+HSANV HRDLKP+NL+ N +C+LKI DFGL+R + Sbjct: 148 EESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSEL 207 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 T+YV+TRWYR PELLL +++Y+ A+D+WSVGCIF E+ +RKP+FPGR+ + QLR++ + I Sbjct: 208 TDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHI 267 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTV--HPLAIDLIEKMLTFDPRRRIT 338 G P +E + A + +LP I P + + ID + KM T DP +R T Sbjct: 268 GKPPASIVE--HREALEKLNELPDGSLN-IPKLVPGLAGNTEGIDFLSKMWTLDPSKRPT 324 Query: 339 VLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 391 D LAHPYL LHD DEP C PF + E+ + +++ + + + +NP Sbjct: 325 AADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >3FI2-A nrPDB Length = 353 Score = 343 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 139/357 (38%), Positives = 206/357 (57%), Gaps = 27/357 (7%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ A Sbjct: 9 QFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 67 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 KR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 68 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDH 125 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 223 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Y Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 185 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 VVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +GTP Sbjct: 186 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 244 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTV------------HPLAIDLIEKMLTF 331 E ++ L + Y+ P Y + FP A DL+ KML Sbjct: 245 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 304 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALA 388 DP +RI+V DAL HPY+N + + + E+ KELIY+E + Sbjct: 305 DPAKRISVDDALQHPYINVWYXXX----------XXXDEREHTIEEWKELIYKEVMN 351 >3RP9-A nrPDB Length = 458 Score = 338 bits (866), Expect = 3e-93, Method: Composition-based stats. Identities = 145/402 (36%), Positives = 217/402 (53%), Gaps = 62/402 (15%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +++ +Y+ IG G+YG VC A + VAIKKI F++ ID KR LREI + Sbjct: 47 SDWQIPDRYEIR-HLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAI 105 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQI 173 L ++H+++V + DI+ P F+++Y+ E+ D+D ++ R+ L+E H + LY + Sbjct: 106 LNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--------------ESDF 219 L G+KY+HSA +LHRDLKP+N L+N +C +K+CDFGLAR E D Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 220 --------------MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD------ 259 +T +VVTRWYRAPEL+L +YT AIDVWS+GCIF EL++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 260 -----RKPLFPGRD--------------------HVHQLRLLMELIGTPSEEELEFL-NE 293 R PLFPG + QL ++ ++GTPSEE++E L E Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 +AKRYIR P + ++FP AI L+++ML F+P +RIT+ + LAHP+ + Sbjct: 346 DAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRI 405 Query: 354 ISDEPECTIPFNFDF-ENHALSEEQMKELIYREALAFNPEYQ 394 E T F + + E Q++ +E ++PE Q Sbjct: 406 AEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQ 447 >3OZ6-A nrPDB Length = 388 Score = 331 bits (849), Expect = 3e-91, Method: Composition-based stats. Identities = 136/372 (36%), Positives = 213/372 (57%), Gaps = 51/372 (13%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-H 119 + + +GKGAYGIV +++ T E VA+KKI +AF N DA+RT REI +L + H Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGH 68 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 ENIV + +++ + DVY+ ++ M+TDLH +IR+N L H QY +YQ+++ +KY Sbjct: 69 ENIVNLLNVLRA---DNDRDVYLVFDYMETDLHAVIRAN-ILEPVHKQYVVYQLIKVIKY 124 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----------------------SES 217 +HS +LHRD+KPSN+LLNA C +K+ DFGL+R + Sbjct: 125 LHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQ 184 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 +T+YV TRWYRAPE+LL S+ YT ID+WS+GCI E++ KP+FPG ++QL ++ Sbjct: 185 PILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERII 244 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYP-------RQSITDKFPTV----------HPL 320 +I PS E++E + + + + ++ I K+ + + Sbjct: 245 GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEE 304 Query: 321 AIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC----TIPFNFDFENHALSEE 376 A+DL++K+L F+P +RI+ DAL HP+++ H+ ++EP C TIP N +N S + Sbjct: 305 ALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPIN---DNVKHSID 361 Query: 377 QMKELIYREALA 388 + L+Y E Sbjct: 362 DYRNLVYSEISR 373 >2BPM-A nrPDB Length = 309 Score = 331 bits (849), Expect = 3e-91, Method: Composition-based stats. Identities = 109/311 (35%), Positives = 162/311 (52%), Gaps = 9/311 (2%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 V + + IG+G YG+V A N T E VA+KKI + + +REI LL+ + Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILR 175 +H NIV + D+I N +Y+ +E + DL + + ++ + + +L+Q+L+ Sbjct: 64 NHPNIVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPEL 234 GL + HS VLHRDLKP NLL+N +K+ DFGLAR T VVT WYRAPE+ Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 LL Y+ A+D+WS+GCIF E++ R+ LFPG + QL + +GTP E + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 Y P + RQ + P + L+ +ML +DP +RI+ ALAHP+ + Sbjct: 239 P-DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 Query: 355 SDEPECTIPFN 365 P Sbjct: 298 VPHLRLERPHR 308 >3PG1-A nrPDB Length = 362 Score = 324 bits (831), Expect = 4e-89, Method: Composition-based stats. Identities = 138/363 (38%), Positives = 197/363 (54%), Gaps = 15/363 (4%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA-- 97 + G ++ + + + Y I G+YG VC+ ++SE VAIK++ N Sbjct: 2 MQAKGEAAMRDLIAELHAMQSPYTVQ-RFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVS 59 Query: 98 -------FDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD 150 + KR LREI+LL H H NI+ +RDI A + +Y+ ELM TD Sbjct: 60 DGRTVNILSDSFLCKRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTD 119 Query: 151 LHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 L Q+I + +S +H QYF+Y IL GL +H A V+HRDL P N+LL N D+ ICDF Sbjct: 120 LAQVIHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFN 179 Query: 210 LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 LAR + T YV RWYRAPEL++ +T +D+WS GC+ E+ +RK LF G Sbjct: 180 LAREDTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTF 239 Query: 270 VHQLRLLMELIGTPSEEE-LEFLNENAKRYIRQ-LPPYPRQSITDKFPTVHPLAIDLIEK 327 +QL ++E++GTP E+ + F + +A+ Y+R L P ++ T PT P+A+DLI K Sbjct: 240 YNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAK 299 Query: 328 MLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREAL 387 ML F+P+RRI+ AL HPY SL D D E + F F+ M ++ E Sbjct: 300 MLEFNPQRRISTEQALRHPYFESLFDPLDLTE-GLSERFHFDESVTDVYDMHKIFTAEVE 358 Query: 388 AFN 390 FN Sbjct: 359 RFN 361 >3N9X-A nrPDB Length = 432 Score = 323 bits (828), Expect = 9e-89, Method: Composition-based stats. Identities = 140/403 (34%), Positives = 215/403 (53%), Gaps = 54/403 (13%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 102 GR Y V Y IG+G+YG V A + T ++VAIKK+ F++ I Sbjct: 9 SGRENLYFQGIKNVHVPDNYIIK-HLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLI 67 Query: 103 DAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALS 162 D KR LREI +L + + I+ + D+I P F+++YI E+ D+DL ++ ++ L+ Sbjct: 68 DCKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLT 127 Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES----- 217 EEH + LY +L G +IH + ++HRDLKP+N LLN +C +K+CDFGLAR + Sbjct: 128 EEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNI 187 Query: 218 ------------------DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM- 258 +T +VVTRWYRAPEL+L +YT +ID+WS GCIF EL+ Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 Query: 259 ----------DRKPLFPG-----------------RDHVHQLRLLMELIGTPSEEELEFL 291 +R PLFPG + + QL ++ +IGTP+E++L+ + Sbjct: 248 MLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI 307 Query: 292 NE-NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N+ +YI+ P ++ K+P++ I+L+E ML F+P +RIT+ AL HPYL Sbjct: 308 NKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 Query: 351 LHDISDEPECTIPFNFDFENH-ALSEEQMKELIYREALAFNPE 392 + E T F++ LSE Q++ + +E +F+PE Sbjct: 368 VRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHPE 410 >5JN2-A nrPDB Length = 525 Score = 322 bits (825), Expect = 2e-88, Method: Composition-based stats. Identities = 99/366 (27%), Positives = 158/366 (43%), Gaps = 57/366 (15%) Query: 1 MDGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTA 60 + G +G+P + GG P ++ AT G F+Q++ + Sbjct: 26 LGGAAGEPRSRGHAAGTSGG-----PGD------HLHAT---PGMFVQHSTA----IFSD 67 Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDH 119 +YK +GKG++G V + T + A+K I K D + LRE++LL+ +DH Sbjct: 68 RYKGQ-RVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + + Y+ E +L I S + SE + Q+L G+ Sbjct: 127 PNIMKLYEFFEDKGY-----FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 181 Query: 179 YIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y+H ++HRDLKP NLLL + + +++I DFGL+ S M + + T +Y APE+L Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 241 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y DVWS G I L+ P F G + L+ + + Sbjct: 242 --HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------- 282 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 +Y +LP + + V A DLI KMLT+ P RI+ DAL H ++ + Sbjct: 283 GKYTFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 333 Query: 356 DEPECT 361 + Sbjct: 334 ISVDVP 339 >3NIZ-A nrPDB Length = 311 Score = 320 bits (821), Expect = 5e-88, Method: Composition-based stats. Identities = 106/298 (35%), Positives = 169/298 (56%), Gaps = 8/298 (2%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+ + + +G+G YG+V A +S+ VA+K+I +++ +REI LL+ Sbjct: 16 FQGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLK 74 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQIL 174 + H NIV++ D+I ++ + + +E M+ DL +++ N+ L + + +LYQ+L Sbjct: 75 ELHHPNIVSLIDVI-----HSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLL 129 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPE 233 RG+ + H +LHRDLKP NLL+N++ LK+ DFGLAR T VVT WYRAP+ Sbjct: 130 RGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPD 189 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L+ S Y+ ++D+WS+GCIF E++ KPLFPG QL + ++GTP+ E + E Sbjct: 190 VLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQE 249 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 R + ++ + P IDL+ ML FDP +RI+ DA+ HPY L Sbjct: 250 LPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL 307 >6GU6-A nrPDB Length = 302 Score = 316 bits (811), Expect = 7e-87, Method: Composition-based stats. Identities = 108/297 (36%), Positives = 164/297 (55%), Gaps = 10/297 (3%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE 120 + I IG+G YG+V + T + VA+KKI + + +REI LL+ + H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQILRGL 177 NIV+++D++ R +Y+ +E + DL + + S Q + + +LYQIL+G+ Sbjct: 67 NIVSLQDVLMQDSR-----LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 121 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLL 236 + HS VLHRDLKP NLL++ +K+ DFGLAR T VVT WYR+PE+LL Sbjct: 122 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 181 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 S+ Y+ +D+WS+G IF EL +KPLF G + QL + +GTP+ E + E+ + Sbjct: 182 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV-ESLQ 240 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 Y P + S+ + +DL+ KML +DP +RI+ AL HPY N L + Sbjct: 241 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 297 >3NIE-A nrPDB Length = 429 Score = 315 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 136/408 (33%), Positives = 214/408 (52%), Gaps = 57/408 (13%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 S +V Y+ IG+G+YG V A + N++VAIKK+ F++ Sbjct: 9 SGRENLYFQGAIIKNVKVPDNYEIK-HLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 ID KR LREI +L + + I+ + D+I P F+++YI E+ D+DL ++ ++ Sbjct: 68 LIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF 127 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES--- 217 L+E+H + LY +L G K+IH + ++HRDLKP+N LLN +C +KICDFGLAR + Sbjct: 128 LTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDI 187 Query: 218 -----------------------DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIF 254 +T +VVTRWYRAPEL+L +YT +ID+WS GCIF Sbjct: 188 HIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIF 247 Query: 255 MELM-----------DRKPLFPG-----------------RDHVHQLRLLMELIGTPSEE 286 EL+ +R PLFPG + + QL ++ +IGTP EE Sbjct: 248 AELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEE 307 Query: 287 ELEFLNE-NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +L+ + + +YI+ P ++ K+ ++ IDL+E ML F+ ++RIT+ AL+H Sbjct: 308 DLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSH 367 Query: 346 PYLNSLHDISDEPECTIPFNFDFENH-ALSEEQMKELIYREALAFNPE 392 PYL + + E T F++ LSE Q++ + +E +F+ + Sbjct: 368 PYLKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEIQSFHAD 415 >4AGU-A nrPDB Length = 311 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 100/302 (33%), Positives = 167/302 (55%), Gaps = 9/302 (2%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 KY+ I IG+G+YG+V N +T + VAIKK + D+ + K LREI++L+ + Sbjct: 2 MEKYE-KIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGL 177 H N+V + ++ R +++ +E D LH++ R + + E + +Q L+ + Sbjct: 61 HPNLVNLLEVFRRKRR-----LHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAV 115 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLL 236 + H N +HRD+KP N+L+ + +K+CDFG AR+ SD+ + V TRWYR+PELL+ Sbjct: 116 NFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLV 175 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 + Y +DVW++GC+F EL+ PL+PG+ V QL L+ + +G + + N Sbjct: 176 GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQY 235 Query: 297 RYIRQLP-PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 ++P P + + KFP + A+ L++ L DP R+T L HPY ++ +I Sbjct: 236 FSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIE 295 Query: 356 DE 357 D Sbjct: 296 DL 297 >1G3N-A nrPDB Length = 326 Score = 307 bits (787), Expect = 5e-84, Method: Composition-based stats. Identities = 107/310 (34%), Positives = 165/310 (53%), Gaps = 10/310 (3%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMN-SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IG+GAYG V A + VA+K++ + T+RE+ +LRH++ Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLE 69 Query: 119 ---HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEEHCQYFLYQI 173 H N+V + D+ + + + +E +D DL + + E + ++Q+ Sbjct: 70 TFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 LRGL ++HS V+HRDLKP N+L+ ++ +K+ DFGLAR+ S +T VVT WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +LL SS Y +D+WSVGCIF E+ RKPLF G V QL ++++IG P EE+ Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 ++ P I + L DL+ K LTF+P +RI+ AL+HPY L Sbjct: 249 LPRQAFHSKSAQP---IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 Query: 354 ISDEPECTIP 363 + + +P Sbjct: 306 CKENLDSHLP 315 >4KRC-A nrPDB Length = 317 Score = 303 bits (777), Expect = 6e-83, Method: Composition-based stats. Identities = 99/301 (32%), Positives = 157/301 (52%), Gaps = 17/301 (5%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 + +G G Y V +N T VA+K++ + +REI L++ + HENIV Sbjct: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVK-LDSEEGTPSTAIREISLMKELKHENIV 66 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN------QALSEEHCQYFLYQILRGL 177 + D+I N + + +E MD DL + + S + L +YF +Q+L+GL Sbjct: 67 RLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLL 236 + H +LHRDLKP NLL+N LK+ DFGLAR + + VVT WYRAP++L+ Sbjct: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 S Y+ +ID+WS GCI E++ KPLFPG + QL+L+ +++GTP+E + + K Sbjct: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Query: 297 R--YIRQLPPYPRQSITDKF--PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 I+Q PP + + + +D + +L +P R++ AL HP+ + Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 Query: 353 D 353 Sbjct: 302 H 302 >1V0B-A nrPDB Length = 288 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 111/294 (37%), Positives = 155/294 (52%), Gaps = 10/294 (3%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 KY + IG+G YG+V A N+ E+ A+KKI +++ T+REI +L+ + Sbjct: 1 MEKYHG-LEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELK 58 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGL 177 H NIV + D+I R + + +E +D DL +++ L + FL Q+L G+ Sbjct: 59 HSNIVKLYDVIHTKKR-----LVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGI 113 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLL 236 Y H VLHRDLKP NLL+N +LKI DFGLAR T VVT WYRAP++L+ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLM 173 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 S Y+ ID+WSVGCIF E+++ PLFPG QL + ++GTP+ + + E K Sbjct: 174 GSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPK 233 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 Y Y + IDL+ KML DP +RIT AL H Y Sbjct: 234 -YDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 301 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 111/299 (37%), Positives = 170/299 (56%), Gaps = 9/299 (3%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 ++ + IG+G YG V A N ET+E VA+K++ D++ LREI LL+ + Sbjct: 4 GSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELK 63 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQYFLYQILRGL 177 H+NIV + D++ ++ + + +E D DL + S N L E + FL+Q+L+GL Sbjct: 64 HKNIVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLL 236 + HS NVLHRDLKP NLL+N N +LK+ DFGLAR + VVT WYR P++L Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 237 NSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + Y+ +ID+WS GCIF EL + +PLFPG D QL+ + L+GTP+EE+ + + Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 238 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 + P S+ + P ++ DL++ +L +P +RI+ +AL HPY + Sbjct: 239 DYKPYPMYP-ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4BBM-A nrPDB Length = 331 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 100/297 (33%), Positives = 163/297 (54%), Gaps = 9/297 (3%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+ KY+ + +G+G+YG+V N +T VAIKK + D+K+ K +REIKLL+ Sbjct: 21 FQSMEKYEN-LGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLK 79 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQIL 174 + HEN+V + ++ R Y+ +E +D + + L + Q +L+QI+ Sbjct: 80 QLRHENLVNLLEVCKKKKRW-----YLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII 134 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPE 233 G+ + HS N++HRD+KP N+L++ + +K+CDFG AR + + + V TRWYRAPE Sbjct: 135 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 LL+ Y A+DVW++GC+ E+ +PLFPG + QL +M +G E N+ Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 254 Query: 294 NAKRYIRQLPPYP-RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 N +LP R+ + ++P + + IDL +K L DP +R + L H + Sbjct: 255 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3NCG-A nrPDB Length = 486 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 92/324 (28%), Positives = 140/324 (43%), Gaps = 37/324 (11%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 A+ + +GKG++G V + T + A+K I A D LRE++LL+ +DH Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + +I+ YI E +L I + SE + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 179 YIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y+H N++HRDLKP N+LL + +CD+KI DFGL+ ++ M + + T +Y APE+L Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y DVWS G I L+ P F G++ L+ + Sbjct: 196 --RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ET 236 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 +Y LP + T+ A DLI KMLTF P RIT L HP++ + Sbjct: 237 GKYAFDLPQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSET 287 Query: 356 DEPECTIPFNFDFENHALSEEQMK 379 N + + K Sbjct: 288 PTISDLPSLESAMTNIRQFQAEKK 311 >3MA6-A nrPDB Length = 298 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 94/331 (28%), Positives = 147/331 (44%), Gaps = 45/331 (13%) Query: 30 MPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV 89 G EN+ G F+Q++ + +YK +GKG++G V + T + Sbjct: 8 SSGRENLYF--QGPGMFVQHSTA----IFSDRYKGQ-RVLGKGSFGEVILCKDKITGQEC 60 Query: 90 AIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYE-LM 147 A+K I K D + LRE++LL+ +DH NI+ + + Y+ E Sbjct: 61 AVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGY-----FYLVGEVYT 115 Query: 148 DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NANCDLK 204 +L I S + SE + Q+L G+ Y+H ++HRDLKP NLLL + + +++ Sbjct: 116 GGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIR 175 Query: 205 ICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 I DFGL+ S M + + T +Y APE+L Y DVWS G I L+ P F Sbjct: 176 IIDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPF 233 Query: 265 PGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 G + L+ + + +Y +LP + + V A DL Sbjct: 234 NGANEYDILKKVEK-----------------GKYTFELPQWKK---------VSESAKDL 267 Query: 325 IEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 I KMLT+ P RI+ DAL H ++ + Sbjct: 268 IRKMLTYVPSMRISARDALDHEWIQTYTKEQ 298 >5EFQ-A nrPDB Length = 347 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 108/307 (35%), Positives = 162/307 (52%), Gaps = 9/307 (2%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG+G YG V A + +T E VA+KK+ + + +REIK+LR + H++I+ + Sbjct: 16 IGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINM 75 Query: 126 RDIIPPP-----LRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKY 179 ++I+ + Y+ +E MD DL ++ S +E H + F+ Q++ GL Y Sbjct: 76 KEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDY 135 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELLLN 237 H N LHRD+K SN+LLN +K+ DFGLAR+ S ES T V+T WYR PELLL Sbjct: 136 CHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLG 195 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 YT AIDVWS GCI EL +KP+F + QL L+ + G+P + + Sbjct: 196 EERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYF 255 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDE 357 + R+ + ++F + A+DL + ML DP +R T AL +L + + S Sbjct: 256 NTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV-EPSKM 314 Query: 358 PECTIPF 364 P +P Sbjct: 315 PPPDLPL 321 >3DFA-A nrPDB Length = 286 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 90/297 (30%), Positives = 135/297 (45%), Gaps = 37/297 (12%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 A+ + +GKG++G V + T + A+K I A D LRE++LL+ +DH Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + +I+ YI E +L I + SE + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 179 YIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y+H N++HRDLKP N+LL + +CD+KI DFGL+ ++ M + + T +Y APE+L Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y DVWS G I L+ P F G++ L+ + Sbjct: 196 --RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-----------------ET 236 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 +Y LP + T+ A DLI KMLTF P RIT L HP++ Sbjct: 237 GKYAFDLPQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYS 284 >4MVF-A nrPDB Length = 506 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 86/332 (25%), Positives = 148/332 (44%), Gaps = 41/332 (12%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + ++ KY +G+G YG V ++ TN+ AIK+ D + R +EI++ Sbjct: 51 HSGKLEDKYIID-EKLGQGTYGCVYKGIDKVTNQLYAIKEEKK--DRLKNINRFFQEIEI 107 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQ 172 ++ +DH NIV + + N +Y+ EL +L I N + +E++ + Q Sbjct: 108 MKKLDHPNIVKLYETYEND-----NYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQ 162 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 I + Y+HS N++HRDLKP N L N + LKI DFGL++ +F T T +Y Sbjct: 163 IFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYY 222 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 AP++L Y D+WS G I L+ P F G L+ + Sbjct: 223 VAPQVL--DGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKV------------- 267 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + + ++ A +LI K+LT++P R T+ +AL HP++ Sbjct: 268 -------------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWIT 314 Query: 350 SLHDISDEPECTIPFNFDFENHALSEEQMKEL 381 + + E + + +N E ++K++ Sbjct: 315 QMTKSHEHVELSSTLLKNLKNFK-KENELKKI 345 >1UA2-A nrPDB Length = 346 Score = 296 bits (759), Expect = 7e-81, Method: Composition-based stats. Identities = 109/309 (35%), Positives = 163/309 (52%), Gaps = 14/309 (4%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA---KRTLREIKLLRH 116 AK + +G+G + V A + TN+ VAIKKI ++ + LREIKLL+ Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILR 175 + H NI+ + D +++ + ++ M+TDL II+ N L+ H + ++ L+ Sbjct: 69 LSHPNIIGLLDAFGHK-----SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPEL 234 GL+Y+H +LHRDLKP+NLLL+ N LK+ DFGLA+ S + T VVTRWYRAPEL Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 L + Y +D+W+VGCI EL+ R P PG + QL + E +GTP+EE+ + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 +P + F +DLI+ + F+P RIT AL Y ++ Sbjct: 244 PD--YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN--RP 299 Query: 355 SDEPECTIP 363 P C +P Sbjct: 300 GPTPGCQLP 308 >4NST-A nrPDB Length = 351 Score = 296 bits (759), Expect = 9e-81, Method: Composition-based stats. Identities = 108/305 (35%), Positives = 162/305 (53%), Gaps = 12/305 (3%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I IG+G YG V A + +T E VA+KK+ + + +REIK+LR + H ++V + Sbjct: 18 IGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNM 77 Query: 126 RDIIPPP-----LRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKY 179 ++I+ + Y+ +E MD DL ++ S SE+H + F+ Q++ GL+Y Sbjct: 78 KEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEY 137 Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELLLN 237 H N LHRD+K SN+LLN + +K+ DFGLAR+ + ES T V+T WYR PELLL Sbjct: 138 CHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLG 197 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 YT AIDVWS GCI EL +KP+F + QL L+ L G+P + + Sbjct: 198 EERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYF 257 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH----D 353 + R+ + ++F + A+DL++ MLT DP +R T L +L + Sbjct: 258 NTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMA 317 Query: 354 ISDEP 358 D P Sbjct: 318 PPDLP 322 >2I6L-A nrPDB Length = 320 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 131/317 (41%), Positives = 194/317 (61%), Gaps = 18/317 (5%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F++ ++Y + P+G G G+V SA++++ ++ VAIKKI + K LREIK++R Sbjct: 7 FDLGSRYM-DLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIR 63 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDV---------YIAYELMDTDLHQIIRSNQALSEEHC 166 +DH+NIV + +I+ P +DV YI E M+TDL ++ L EEH Sbjct: 64 RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVL-EQGPLLEEHA 122 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSES----DFMT 221 + F+YQ+LRGLKYIHSANVLHRDLKP+NL +N + LKI DFGLAR+ ++ Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 E +VT+WYR+P LLL+ ++YT AID+W+ GCIF E++ K LF G + Q++L++E I Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 341 EE+ + L YIR P + +T P + A+D +E++LTF P R+T + Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 342 ALAHPYLNSLHDISDEP 358 AL+HPY++ DEP Sbjct: 303 ALSHPYMSIYSFPMDEP 319 >2W96-B nrPDB Length = 306 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 107/306 (34%), Positives = 160/306 (52%), Gaps = 13/306 (4%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 T++Y+ P+ IG GAYG V A + + VA+K + + T+RE+ LLR ++ Sbjct: 3 TSRYE-PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLE 61 Query: 119 ---HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQI 173 H N+V + D+ + V + +E +D DL + L E + + Q Sbjct: 62 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ S + VVT WYRAPE Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPE 181 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +LL S+ Y +D+WSVGCIF E+ RKPLF G QL + +LIG P E++ Sbjct: 182 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 + PP + + P + L+ +MLTF+P +RI+ AL H YL H Sbjct: 241 LPRG---AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---HK 294 Query: 354 ISDEPE 359 PE Sbjct: 295 DEGNPE 300 >5G6V-A nrPDB Length = 324 Score = 290 bits (743), Expect = 6e-79, Method: Composition-based stats. Identities = 110/305 (36%), Positives = 162/305 (53%), Gaps = 9/305 (2%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G+G Y V + T+ VA+K+I + +RE+ LL+ + H NI Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPC-TAIREVSLLKDLKHANI 62 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL-SEEHCQYFLYQILRGLKYIH 181 V + DII + + +E +D DL Q + + + + + FL+Q+LRGL Y H Sbjct: 63 VTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSD 240 VLHRDLKP NLL+N +LK+ DFGLAR S + VVT WYR P++LL S+D Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 Y+ ID+W VGCIF E+ +PLFPG QL + ++GTP+EE + N + Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL-HDISDEPE 359 P Y +++ P + DL+ K+L F+ R RI+ DA+ HP+ SL I P+ Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPD 297 Query: 360 CTIPF 364 T F Sbjct: 298 TTSIF 302 >3LIJ-A nrPDB Length = 494 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 84/293 (28%), Positives = 127/293 (43%), Gaps = 37/293 (12%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G GAYG V + T+ AIK I + + L E+ +L+ +DH NI Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 123 VAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 + + D Y+ E +L I +E + Q+L G+ Y+H Sbjct: 99 MKLYDFFEDKRNY-----YLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 182 SANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 N++HRDLKP NLLL + + +KI DFGL+ V M E + T +Y APE+L Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--R 211 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 Y DVWS+G I L+ P F G+ LR + + Sbjct: 212 KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEK-------------------- 251 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + ++ V A DLI++ML FD +RRI+ AL HP++ + Sbjct: 252 ------GKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEM 298 >3MN3-A nrPDB Length = 271 Score = 288 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 79/304 (25%), Positives = 140/304 (46%), Gaps = 41/304 (13%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMDHEN 121 + +G+G++G V A ++ T + VA+K I K D + R REI LR + H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 I+ + D+I +++ + E +L I +SE+ + F QI+ ++Y H Sbjct: 66 IIKLYDVIKSK-----DEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDLKP NLLL+ + ++KI DFGL+ + ++ +F+ + Y APE++ Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +DVWS G I ++ R+ F +E + L +N + Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFD-------------------DESIPVLFKNISNGVYT 221 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 LP + + P A LI++ML +P RI++ + + + D PE Sbjct: 222 LPKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKV-----DLPEYL 265 Query: 362 IPFN 365 +P + Sbjct: 266 LPPD 269 >4YZB-A nrPDB Length = 491 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 94/347 (27%), Positives = 151/347 (43%), Gaps = 52/347 (14%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G PAA+ S ++ G F+Q++ + +YK +GKG++G V Sbjct: 3 GSPAASKSDKLAAT---------PGMFVQHSTAA----FSDRYKGQ-RVLGKGSFGEVIL 48 Query: 80 AMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFN 138 + T + A+K I K D + L+E++LL+ +DH NI+ + + Sbjct: 49 CKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGY---- 104 Query: 139 DVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 Y+ E +L I S + SE + Q+L G+ Y+H ++HRDLKP NLLL Sbjct: 105 -FYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLL 163 Query: 198 N---ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIF 254 + +++I DFGL+ + M + + T +Y APE+L Y DVWS G I Sbjct: 164 ENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVIL 221 Query: 255 MELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKF 314 L+ P F G + L+ + + ++ LP + + Sbjct: 222 YILLSGCPPFNGANEFDILKKVEK-----------------GKFTFDLPQWKK------- 257 Query: 315 PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 V A DLI KML + P RI+ DAL H +L + +D + Sbjct: 258 --VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVP 302 >4REW-A nrPDB Length = 540 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 140/326 (42%), Gaps = 42/326 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRH 116 V + +G G +G V + T VA+K + +D + REI+ L+ Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILR 175 H +I+ + +I P +D+++ E + +L I N L E+ + QIL Sbjct: 63 FRHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILS 117 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 G+ Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ Sbjct: 118 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 177 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 +D+WS G I L+ F ++ + L + Sbjct: 178 SGRLYAGPEVDIWSSGVILYALLCGTLPFD-------------------DDHVPTLFKKI 218 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 I P Y ++P I L++ ML DP +R ++ D H + Sbjct: 219 CDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ----- 262 Query: 356 DEPECTIPFNFDFENHALSEEQMKEL 381 D P+ P + + + + +E +KE+ Sbjct: 263 DLPKYLFPEDPSYSSTMIDDEALKEV 288 >4CFF-A nrPDB Length = 571 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 137/331 (41%), Gaps = 42/331 (12%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREI 111 + V + +G G +G V + T VA+K + +D + REI Sbjct: 25 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 84 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 + L+ H +I+ + +I P D ++ E + +L I + + E + Sbjct: 85 QNLKLFRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 139 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 QIL + Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y Sbjct: 140 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ +D+WS G I L+ F +E + Sbjct: 200 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPT 240 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L + + + +P Y +S+ L+ ML DP +R T+ D H + Sbjct: 241 LFKKIRGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 289 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKEL 381 D P P + ++ + + +E +KE+ Sbjct: 290 -----DLPSYLFPEDPSYDANVIDDEAVKEV 315 >3MIA-A nrPDB Length = 351 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 99/306 (32%), Positives = 155/306 (50%), Gaps = 11/306 (3%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + IG+G +G V A + +T + VA+KK+ + + LREIK+L+ + HEN+ Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 123 VAIRDII---PPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLK 178 V + +I P +Y+ ++ + DL ++ + + + + +L GL Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT-----SESDFMTEYVVTRWYRAPE 233 YIH +LHRD+K +N+L+ + LK+ DFGLAR S+ + T VVT WYR PE Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 LLL DY ID+W GCI E+ R P+ G HQL L+ +L G+ + E ++ Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 Query: 294 NAKRYIRQLPPYPRQSITDKFPTV--HPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 +L ++ + D+ P A+DLI+K+L DP +RI DAL H + S Sbjct: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD 318 Query: 352 HDISDE 357 SD Sbjct: 319 PMPSDL 324 >5EZV-A nrPDB Length = 560 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 137/331 (41%), Gaps = 42/331 (12%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREI 111 + V + +G G +G V + T VA+K + +D + REI Sbjct: 20 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 79 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 + L+ H +I+ + +I P D ++ E + +L I + + E + Sbjct: 80 QNLKLFRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 134 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 QIL + Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y Sbjct: 135 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 194 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ +D+WS G I L+ F +E + Sbjct: 195 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPT 235 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L + + + +P Y +S+ L+ ML DP +R T+ D H + Sbjct: 236 LFKKIRGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 284 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKEL 381 D P P + ++ + + +E +KE+ Sbjct: 285 -----DLPSYLFPEDPSYDANVIDDEAVKEV 310 >2BDW-A nrPDB Length = 362 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 87/340 (25%), Positives = 152/340 (44%), Gaps = 45/340 (13%) Query: 38 ATLSHGGRFIQYNIF--GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIA 95 A+++ G + + + F + + Y +GKGA+ +V ++ T A K I Sbjct: 5 ASMTGGQQMGRGSEFMMNASTKFSDNYDVK-EELGKGAFSVVRRCVHKTTGLEFAAKIIN 63 Query: 96 NAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQI 154 + D ++ RE ++ R + H NIV + D I + Y+ ++L+ +L + Sbjct: 64 TKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFH-----YLVFDLVTGGELFED 118 Query: 155 IRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLA 211 I + + SE + + QIL + Y HS ++HR+LKP NLLL + +K+ DFGLA Sbjct: 119 IVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA 178 Query: 212 RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 ++S+ + T Y +PE+L Y+ +D+W+ G I L+ P F Sbjct: 179 IEVNDSEAWHGFAGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPF------- 230 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 +E+ R Q+ + ++ TV P A LI+ MLT Sbjct: 231 -------------------WDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTV 271 Query: 332 DPRRRITVLDALAHPYLNSLHDIS------DEPECTIPFN 365 +P++RIT AL P++ + ++ D +C FN Sbjct: 272 NPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFN 311 >2VN9-A nrPDB Length = 301 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 142/318 (44%), Gaps = 44/318 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 T +Y+ +GKGA+ +V M T + A K I + D ++ RE ++ R + Sbjct: 3 TDEYQLF-EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV + D I + Y+ ++L+ +L + I + + SE + + QIL + Sbjct: 62 HPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 116 Query: 178 KYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPE 233 + H ++HRDLKP NLLL + +K+ DFGLA V + + T Y +PE Sbjct: 117 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 176 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L Y +D+W+ G I L+ P F +E Sbjct: 177 VL-RKDPYGKPVDMWACGVILYILLVGYPPF--------------------------WDE 209 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL----- 348 + R +Q+ + ++ TV P A DLI KMLT +P +RIT +AL HP++ Sbjct: 210 DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRST 269 Query: 349 -NSLHDISDEPECTIPFN 365 S+ + +C FN Sbjct: 270 VASMMHRQETVDCLKKFN 287 >3HZT-A nrPDB Length = 467 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 81/296 (27%), Positives = 127/296 (42%), Gaps = 39/296 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKRTLREIKLLRH 116 ++ +Y+ + +G GAYG V + T AIK I + ++ L E+ +L+ Sbjct: 2 LSDRYQR-VKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILR 175 +DH NI+ + + Y+ E +L I Q SE + Q+L Sbjct: 61 LDHPNIMKLYEFFEDKRNY-----YLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 176 GLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAP 232 G Y+H N++HRDLKP NLLL + + +KI DFGL+ M E + T +Y AP Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 E+L Y DVWS G I L+ P F G+ L+ + + Sbjct: 176 EVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK-------------- 219 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + V A L++ MLT++P +RI+ +AL HP++ Sbjct: 220 ------------GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 283 bits (725), Expect = 8e-77, Method: Composition-based stats. Identities = 81/298 (27%), Positives = 125/298 (41%), Gaps = 38/298 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKRTLREIKLL 114 F+ + + +G GAYG V + T AIK I + ++ L E+ +L Sbjct: 16 FQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVL 75 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQI 173 + +DH NI+ + + Y+ E +L I Q SE + Q+ Sbjct: 76 KQLDHPNIMKLYEFFEDKRNY-----YLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQV 130 Query: 174 LRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 L G Y+H N++HRDLKP NLLL + + +KI DFGL+ M E + T +Y Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE+L Y DVWS G I L+ P F G+ L+ + + Sbjct: 191 APEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK------------ 236 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + V A L++ MLT++P +RI+ +AL HP++ Sbjct: 237 --------------GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >4CFH-A nrPDB Length = 493 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 82/331 (24%), Positives = 141/331 (42%), Gaps = 42/331 (12%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREI 111 + V + +G G +G V + T VA+K + +D + REI Sbjct: 25 KHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREI 84 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 + L+ H +I+ + +I P +D+++ E + +L I N L E+ + Sbjct: 85 QNLKLFRHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 139 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 QIL G+ Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ +D+WS G I L+ F ++ + Sbjct: 200 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD-------------------DDHVPT 240 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L + I P Y ++P I L++ ML DP +R T+ D H + Sbjct: 241 LFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKEL 381 D P+ P + + + + +E +KE+ Sbjct: 290 -----DLPKYLFPEDPSYSSTMIDDEALKEV 315 >4RED-A nrPDB Length = 351 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 140/326 (42%), Gaps = 42/326 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRH 116 V + +G G +G V + T +VA+K + +D + REI+ L+ Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILR 175 H +I+ + +I P +D+++ E + +L I N L E+ + QIL Sbjct: 71 FRHPHIIKLYQVISTP-----SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILS 125 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 G+ Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ Sbjct: 126 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 +D+WS G I L+ F ++ + L + Sbjct: 186 SGRLYAGPEVDIWSSGVILYALLCGTLPFD-------------------DDHVPTLFKKI 226 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 I P Y ++P I L++ ML DP +R ++ D H + Sbjct: 227 CDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ----- 270 Query: 356 DEPECTIPFNFDFENHALSEEQMKEL 381 D P+ P + + + +E +KE+ Sbjct: 271 DLPKYLFPEDPSYSTTMIDDEALKEV 296 >4BGQ-A nrPDB Length = 304 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 99/302 (32%), Positives = 172/302 (56%), Gaps = 12/302 (3%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 NI V K++ + +G+GAYG+V + ET+E VAIKK ++ +N+ + TLRE+K+ Sbjct: 6 NIGNVMNKFEI-LGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKM 64 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQ 172 LR + ENIV +++ +Y+ +E ++ ++ +++ + E + ++YQ Sbjct: 65 LRTLKQENIVELKEAF-----RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD--FMTEYVVTRWYR 230 +++ + + H +++HRD+KP NLL++ N LK+CDFG AR SE + E V TRWYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 +PELLL + Y ++D+WSVGCI EL D +PLFPG + QL + +++G E+++ Sbjct: 180 SPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 291 LNENAKRYIRQLPP--YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 N + + + P +P+ ++ + +DL++ +L DP R L HP Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 Query: 349 NS 350 + Sbjct: 299 QT 300 >5YKS-A nrPDB Length = 377 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 83/325 (25%), Positives = 140/325 (43%), Gaps = 42/325 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G+G + +V A + T E VA+K I + + +E++ ++ + H NIV + Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLY 100 Query: 127 DIIPPPLRNAFNDVYIAYELMDT-DLHQII-RSNQALSEEHCQYFLYQILRGLKYIHSAN 184 ++I + +Y+ EL D D+ I + + L+E+ + + QI+ + Y H + Sbjct: 101 EVIDTQTK-----LYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 185 VLHRDLKPSNL-LLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 V+HRDLKP N+ +K+ DFG + +T + Y APE+LL Sbjct: 156 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 A+D+WS+G I L+ +P F + L ++M+ T Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH----------------- 258 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIP 363 V DLI +ML DP+RR ++ + HP+L + D S + IP Sbjct: 259 -------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPATKYNIP 304 Query: 364 FNFDFENHALSEEQMKELIYREALA 388 LSEE+ +I R L Sbjct: 305 L---VSYKNLSEEEHNSIIQRMVLG 326 >5U6Y-A nrPDB Length = 461 Score = 280 bits (717), Expect = 6e-76, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 137/314 (43%), Gaps = 43/314 (13%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 +GKGA+ +V + + A K I + D ++ RE ++ R + H NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + D I + Y+ ++L+ +L + I + + SE + + QIL + + H Sbjct: 62 VRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 116 Query: 182 SANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLN 237 V+HRDLKP NLLL + +K+ DFGLA V E + T Y +PE+L Sbjct: 117 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-R 175 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 Y +D+W+ G I L+ P F +E+ R Sbjct: 176 KDPYGKPVDLWACGVILYILLVGYPPF--------------------------WDEDQHR 209 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN------SL 351 +Q+ + ++ TV P A DLI KMLT +P +RIT +AL HP+++ S Sbjct: 210 LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASC 269 Query: 352 HDISDEPECTIPFN 365 + +C FN Sbjct: 270 MHRQETVDCLKKFN 283 >5AIR-A nrPDB Length = 430 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 105/313 (33%), Positives = 167/313 (53%), Gaps = 21/313 (6%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 IG G++G+V A ++ E VAIKK+ D + RE++++R +DH NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ------DKRFKNRELQIMRKLDHCNI 119 Query: 123 VAIRDIIPPPLRNAFNDVYI------AYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 V +R ++VY+ E + R+ Q L + + ++YQ+ R Sbjct: 120 VRLRYFFYSSGEKK-DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDL-KICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 L YIHS + HRD+KP NLLL+ + + K+CDFG A+ + Y+ +R+YRAPEL+ Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 238 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 ++DYT++IDVWS GC+ EL+ +P+FPG V QL +++++GTP+ E++ +N N Sbjct: 239 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 298 Query: 296 KRYIRQLPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 + + P T F P P AI L ++L + P R+T L+A AH + + L D Sbjct: 299 TEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD- 355 Query: 355 SDEPECTIPFNFD 367 P +P D Sbjct: 356 ---PNVKLPNGRD 365 >2QNJ-A nrPDB Length = 328 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 74/339 (21%), Positives = 140/339 (41%), Gaps = 48/339 (14%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + IGKG + V A + T VAIK I N ++ RE+++++ ++H NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + ++I +Y+ E ++ + ++ + E+ + QI+ ++Y H Sbjct: 74 VKLFEVIETE-----KTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 128 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDLK NLLL+A+ ++KI DFG + + + + + Y APEL Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +DVWS+G I L+ F G++ L+ L E R + Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKYR 229 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 +P Y + +L+++ L +P +R T+ + ++N+ H+ + Sbjct: 230 IPFY-----------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFV 278 Query: 362 IPFNFDFENHALSE------------EQMKELIYREALA 388 P + + E + ++ Y E A Sbjct: 279 EPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITA 317 >3H4J-B nrPDB Length = 336 Score = 280 bits (716), Expect = 9e-76, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 136/302 (45%), Gaps = 40/302 (13%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHEN 121 +G+G++G V A + +T + VA+K I+ K D R REI L+ + H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 I+ + D+I P D+ + E +L I + ++E+ + F QI+ ++Y H Sbjct: 71 IIKLYDVITTP-----TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCH 125 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDLKP NLLL+ N ++KI DFGL+ + ++ +F+ + Y APE++ Sbjct: 126 RHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYA 185 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +DVWS G + ++ + F +E + L + + Sbjct: 186 GPEVDVWSCGIVLYVMLVGRLPFD-------------------DEFIPNLFKKVNSCVYV 226 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN----SLHDISDE 357 +P + + P A LI +M+ DP +RIT+ + P+ N +E Sbjct: 227 MPDF-----------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEE 275 Query: 358 PE 359 + Sbjct: 276 VQ 277 >2V7O-A nrPDB Length = 336 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 144/328 (43%), Gaps = 44/328 (13%) Query: 49 YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL 108 + T Y+ +GKGA+ +V + + A K I + D ++ Sbjct: 20 FQSMATCTRFTDDYQLF-EELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLE 78 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQ 167 RE ++ R + H NIV + D I + Y+ ++L+ +L + I + + SE Sbjct: 79 REARICRLLKHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADAS 133 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEY 223 + ++QIL + +IH +++HRDLKP NLLL + C +K+ DFGLA V E + Sbjct: 134 HCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGF 193 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 T Y +PE+L Y +D+W+ G I L+ P F Sbjct: 194 AGTPGYLSPEVL-RKDPYGKPVDIWACGVILYILLVGYPPF------------------- 233 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 +E+ + +Q+ + ++ TV P A +LI +MLT +P +RIT AL Sbjct: 234 -------WDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQAL 286 Query: 344 AHPY------LNSLHDISDEPECTIPFN 365 HP+ + S+ + EC FN Sbjct: 287 KHPWVCQRSTVASMMHRQETVECLRKFN 314 >2VZ6-A nrPDB Length = 313 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 137/314 (43%), Gaps = 43/314 (13%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 +GKGA+ +V + + A K I + D ++ RE ++ R + H NI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + D I + Y+ ++L+ +L + I + + SE + + QIL + + H Sbjct: 84 VRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 138 Query: 182 SANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLN 237 V+HRDLKP NLLL + +K+ DFGLA V E + T Y +PE+L Sbjct: 139 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL-R 197 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 Y +D+W+ G I L+ P F +E+ R Sbjct: 198 KDPYGKPVDLWACGVILYILLVGYPPF--------------------------WDEDQHR 231 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN------SL 351 +Q+ + ++ TV P A DLI KMLT +P +RIT +AL HP+++ S Sbjct: 232 LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASC 291 Query: 352 HDISDEPECTIPFN 365 + +C FN Sbjct: 292 MHRQETVDCLKKFN 305 >4RGJ-A nrPDB Length = 520 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 99/386 (25%), Positives = 154/386 (39%), Gaps = 49/386 (12%) Query: 3 GGSGQPAADTEMTEAPGGFPAAAPSPQMPGI--ENIPATLSHGGRFIQYNIFGNIFEVTA 60 G + T GG GI + + + ++ I + Sbjct: 1 GNTKNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNE 60 Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDH 119 +YK I +GKG++G V + + T AIK I K D + LRE++LL+ +DH Sbjct: 61 QYKG-IKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + + Y+ + +L I S + E + QIL G+ Sbjct: 120 INIMKLYEFFEDNNYY-----YLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGIT 174 Query: 179 YIHSANVLHRDLKPSNLLL----NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 Y+H NV+HRDLKP N+LL + +KI DFGL+ S M + + T +Y AP++ Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 L Y D+WS G I L+ P F G + L+ + Sbjct: 235 L--HGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV-----------------E 275 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 A +Y LP F + A DLI+KML + RI+ DAL H ++ + Sbjct: 276 AGKYTFDLPQ---------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMM--- 323 Query: 355 SDEPECTIPFNFDFENHALSEEQMKE 380 N D + LS +++ Sbjct: 324 ----TSKDNLNIDIPSLELSIANIRQ 345 >3KK8-A nrPDB Length = 284 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 135/293 (46%), Gaps = 36/293 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +GKGA+ +V ++ T A K I + D ++ RE ++ R + H NIV + Sbjct: 12 EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLH 71 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 D I + Y+ ++L+ +L + I + + SE + + QIL + Y HS + Sbjct: 72 DSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGI 126 Query: 186 LHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 +HR+LKP NLLL + +K+ DFGLA ++S+ + T Y +PE+L Y+ Sbjct: 127 VHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KKDPYS 185 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 +D+W+ G I L+ P F +E+ R Q+ Sbjct: 186 KPVDIWACGVILYILLVGYPPF--------------------------WDEDQHRLYAQI 219 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 + ++ TV P A LI+ MLT +P++RIT AL P++ + ++ Sbjct: 220 KAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVA 272 >5FG8-A nrPDB Length = 285 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 131/294 (44%), Gaps = 37/294 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +GKGA+ IV + T A K I D ++ RE ++ R + H NIV + Sbjct: 20 EELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 79 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 D I + Y+ ++L+ +L + I + + SE + + QIL + + H V Sbjct: 80 DSIQEENYH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 134 Query: 186 LHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 +HRDLKP NLLL + +K+ DFGLA V + + T Y +PE+L Y Sbjct: 135 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-KKEPY 193 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 ++D+W+ G I L+ P F +E+ R Q Sbjct: 194 GKSVDIWACGVILYILLVGYPPF--------------------------WDEDQHRLYSQ 227 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 + + ++ TV P A +LI +MLT +P +RIT +AL HP++ ++ Sbjct: 228 IKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVA 281 >3BHH-A nrPDB Length = 295 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 142/318 (44%), Gaps = 44/318 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 T +Y+ IGKGA+ +V + T A K I + D ++ RE ++ R + Sbjct: 3 TDEYQL-YEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV + D I + Y+ ++L+ +L + I + + SE + + QIL + Sbjct: 62 HSNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 116 Query: 178 KYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRAPE 233 + H V+HRDLKP NLLL + C +K+ DFGLA V + + T Y +PE Sbjct: 117 LHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPE 176 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L Y +D+W+ G I L+ P F +E Sbjct: 177 VL-RKEAYGKPVDIWACGVILYILLVGYPPF--------------------------WDE 209 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY------ 347 + + +Q+ + ++ TV P A +LI +MLT +P +RIT +AL HP+ Sbjct: 210 DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRST 269 Query: 348 LNSLHDISDEPECTIPFN 365 + S+ + EC FN Sbjct: 270 VASMMHRQETVECLKKFN 287 >5IG1-A nrPDB Length = 344 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 140/301 (46%), Gaps = 38/301 (12%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI 111 F ++++V K K + IGKGA+ V +N T E A+K IA + + REI Sbjct: 10 FFDLYDVDLKDKRSV--IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREI 67 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 + + HE+IV++R Y+ +E + +L I + + +E+ + Sbjct: 68 GICSSLQHEHIVSMRRAFRDESH-----FYLVFEYVSGGELFDEIVTRKFYNEKDASACM 122 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTR 227 +QIL L++ HS N++HRDLKP NLLL + N +KI DFGLA + + + T Sbjct: 123 HQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTP 182 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 Y +PE++ Y A+DVW+ G I L+ P F DH Sbjct: 183 GYLSPEVI-RRVPYDTAVDVWACGVILYILLVGYPPFWEEDH------------------ 223 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 347 ++ Q+ + ++ +V A +LI+ ML +P+RR TV + L HP+ Sbjct: 224 --------QKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPW 275 Query: 348 L 348 + Sbjct: 276 I 276 >5ES1-A nrPDB Length = 328 Score = 276 bits (707), Expect = 9e-75, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 36/303 (11%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + IGKG + V A + T VAIK I N ++ RE+++++ ++H NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + ++I +Y+ E ++ + S+ + E+ + QI+ + Y H Sbjct: 77 VKLFEVIETE-----KTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 131 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 N++HRDLK NLLL+A ++KI DFG + + + + + Y APEL Sbjct: 132 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +D+WS+G I L+ F G + L+ L E R + Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPFDGHN-------------------LKELRERVLRGKYR 232 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 +P Y + ++ + L +P +R T+ + ++N ++ + T Sbjct: 233 VPFY-----------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYT 281 Query: 362 IPF 364 P Sbjct: 282 EPE 284 >4E7W-A nrPDB Length = 394 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 104/341 (30%), Positives = 178/341 (52%), Gaps = 20/341 (5%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G E IG G++G+V A E++E VAIKK+ D + RE++ Sbjct: 32 GKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQ------DKRFKNRELQ 84 Query: 113 LLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLH----QIIRSNQALSEEHCQ 167 ++R + H N+V ++ + + + E + ++ + Q + + Sbjct: 85 IMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIK 144 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVT 226 ++YQ+LR L YIHS + HRD+KP NLLL+ + LK+ DFG A++ + Y+ + Sbjct: 145 LYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICS 204 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 R+YRAPEL+ +++YT ID+WS GC+ ELM +PLFPG + QL +++++GTPS E Sbjct: 205 RYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSRE 264 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +++ +N N + + P + F P P AIDLI ++L + P R+T ++AL H Sbjct: 265 QIKTMNPNYMEH--KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCH 322 Query: 346 PYLNSLH----DISDEPECTIPFNFDFENHALSEEQMKELI 382 P+ + L + + E FN+ E ++ + + L+ Sbjct: 323 PFFDELRTGEARMPNGRELPPLFNWTKEELSVRPDLISRLV 363 >3SOA-A nrPDB Length = 444 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 140/320 (43%), Gaps = 44/320 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 T +Y+ +GKGA+ +V + + A I + D ++ RE ++ R Sbjct: 8 RFTEEYQLF-EELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRL 66 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILR 175 + H NIV + D I + Y+ ++L+ +L + I + + SE + + QIL Sbjct: 67 LKHPNIVRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLA-RVTSESDFMTEYVVTRWYRA 231 + + H V+HR+LKP NLLL + +K+ DFGLA V E + T Y + Sbjct: 122 AVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLS 181 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE+L Y +D+W+ G I L+ P F Sbjct: 182 PEVL-RKDPYGKPVDLWACGVILYILLVGYPPF--------------------------W 214 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN-- 349 +E+ R +Q+ + ++ TV P A DLI KMLT +P +RIT +AL HP+++ Sbjct: 215 DEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 274 Query: 350 ----SLHDISDEPECTIPFN 365 S + +C FN Sbjct: 275 STVASCMHRQETVDCLKKFN 294 >3GC0-A nrPDB Length = 329 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 97/295 (32%), Positives = 159/295 (53%), Gaps = 13/295 (4%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I +G+G YG V A+++ TNE+VAIK+I + + +RE+ LL+ + H N Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRN 94 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 I+ ++ +I R +++ +E + DL + + N +S + FLYQ++ G+ + H Sbjct: 95 IIELKSVIHHNHR-----LHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 182 SANVLHRDLKPSNLLLN-----ANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELL 235 S LHRDLKP NLLL+ LKI DFGLAR T ++T WYR PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 L S Y+ ++D+WS+ CI+ E++ + PLFPG + QL + E++G P + + Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA-L 268 Query: 296 KRYIRQLPPYPRQSITDKF-PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + + P + +++ + +DL+ ML DP +RI+ +AL HPY + Sbjct: 269 PDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >3ZDU-A nrPDB Length = 325 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 91/323 (28%), Positives = 158/323 (48%), Gaps = 16/323 (4%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G+G+YG V + T + VAIK + ++ K +REIK L+ HEN+ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVN-KIAMREIKFLKQFHHENL 63 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + ++ + +++ +E +D L ++ L + + +L+QILR + Y+H Sbjct: 64 VNLIEVFRQKKK-----IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 118 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSD 240 S N++HRD+KP N+L++ + K+CDFG AR + D + V TRWYRAPEL+L + Sbjct: 119 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTS 178 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 Y +D+W++GC+ +E+ P P + L ++ +G S +++ Sbjct: 179 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 238 Query: 301 QLPPYPR-QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPE 359 LP ++ K+P ++ L D++ L DP RI+ D L H Y I Sbjct: 239 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIE---- 294 Query: 360 CTIPFNFDFENHALSEEQMKELI 382 F + + L E ++ LI Sbjct: 295 ---KFMPELKAKLLQEAKVNSLI 314 >5KZ7-A nrPDB Length = 346 Score = 273 bits (698), Expect = 9e-74, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 138/314 (43%), Gaps = 37/314 (11%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + IGKG + V A + T + VA+K I N ++ RE+++++ ++H NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + ++I +Y+ E ++ + ++ + E+ + QI+ ++Y H Sbjct: 95 VKLFEVIETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 149 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDLK NLLL+A+ ++KI DFG + + + + + + Y APEL Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 209 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +DVWS+G I L+ F G++ L+ L E R + Sbjct: 210 GPEVDVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKYR 250 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 +P Y + +L++K L +P +R T+ + ++N H+ + Sbjct: 251 IPFY-----------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYV 299 Query: 362 IPFNFDFENHALSE 375 P D+++ +E Sbjct: 300 EPL-PDYKDPRRTE 312 >2JC6-A nrPDB Length = 334 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 129/314 (41%), Gaps = 38/314 (12%) Query: 39 TLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF 98 +++ + ++ K +G GA+ V A T + A+K I Sbjct: 1 SMARENGESSSSWKKQAEDI-KKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKA 59 Query: 99 DNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS 157 K EI +LR + HENIVA+ DI P N +Y+ +L+ +L I Sbjct: 60 L-KGKESSIENEIAVLRKIKHENIVALEDIYESP-----NHLYLVMQLVSGGELFDRIVE 113 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVT 214 +E+ + Q+L + Y+H ++HRDLKP NLL + + I DFGL+++ Sbjct: 114 KGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKME 173 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 + D M+ T Y APE+L Y+ A+D WS+G I L+ P F Sbjct: 174 GKGDVMSTACGTPGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFY--------- 223 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 +EN + Q+ + + + + A D I ++ DP Sbjct: 224 -----------------DENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPN 266 Query: 335 RRITVLDALAHPYL 348 +R T A HP++ Sbjct: 267 KRYTCEQAARHPWI 280 >2YZA-A nrPDB Length = 276 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 75/314 (23%), Positives = 127/314 (40%), Gaps = 42/314 (13%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREI 111 + V + +G G +G V + T VA+K + +D + REI Sbjct: 3 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 62 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 + L+ H +I+ + +I P D ++ E + +L I + + E + Sbjct: 63 QNLKLFRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 117 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 QIL + Y H V+HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + + Y Sbjct: 118 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYA 177 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ +D+WS G I L+ F +E + Sbjct: 178 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPT 218 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L + + + +P Y +S+ L+ ML DP +R T+ D H + Sbjct: 219 LFKKIRGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 Query: 351 LHDISDEPECTIPF 364 D P P Sbjct: 268 -----DLPSYLFPE 276 >4FG9-A nrPDB Length = 320 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 124/290 (42%), Gaps = 37/290 (12%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 +G GA+ V A + T + VAIK IA + EI +L + H NI Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG-SMENEIAVLHKIKHPNI 78 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 VA+ DI + +Y+ +L+ +L I +E ++Q+L +KY+H Sbjct: 79 VALDDIYE-----SGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133 Query: 182 SANVLHRDLKPSNLL---LNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 ++HRDLKP NLL L+ + + I DFGL+++ ++ T Y APE+L Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ- 192 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 Y+ A+D WS+G I L+ P F +EN + Sbjct: 193 KPYSKAVDCWSIGVIAYILLCGYPPFY--------------------------DENDAKL 226 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 Q+ + + + + A D I ++ DP +R T AL HP++ Sbjct: 227 FEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >3E3P-A nrPDB Length = 360 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 109/337 (32%), Positives = 169/337 (50%), Gaps = 30/337 (8%) Query: 70 GKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM---DHENIVAIR 126 G+G +G V T SVAIKK+ D + RE+++++ + H NIV ++ Sbjct: 32 GQGTFGTVQLGKEKSTGMSVAIKKVIQ------DPRFRNRELQIMQDLAVLHHPNIVQLQ 85 Query: 127 DIIPPPLRNAFNDVYI--AYELMDTDLHQ----IIRSNQALSEEHCQYFLYQILRGLKYI 180 D+Y+ E + LH+ R A + FL+Q++R + + Sbjct: 86 SYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCL 145 Query: 181 H--SANVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN 237 H S NV HRD+KP N+L+N + LK+CDFG A+ S S+ Y+ +R+YRAPEL+ Sbjct: 146 HLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFG 205 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 + YT A+D+WSVGCIF E+M +P+F G + QL ++ ++G PS E L LN + Sbjct: 206 NQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTD 265 Query: 298 ---YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 Y + P+ +D A DL+ +L + P R+ +AL HPY + LHD Sbjct: 266 VDLYNSKGIPWS-NVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFDELHDP 324 Query: 355 S-------DEPECTIPFNFDFENHALSEEQMKELIYR 384 + D PE F + E +SE Q +L+ + Sbjct: 325 ATKLPNNKDLPEDLFRFLPN-EIEVMSEAQKAKLVRK 360 >3Q5I-A nrPDB Length = 504 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 76/318 (23%), Positives = 128/318 (40%), Gaps = 49/318 (15%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK--------- 101 + ++ Y + +G GAYG V + AIK I + +K Sbjct: 27 VRKKEGKIGESYF-KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKN 85 Query: 102 --IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSN 158 + EI LL+ +DH NI+ + D+ Y+ E +L + I + Sbjct: 86 IEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKY-----FYLVTEFYEGGELFEQIINR 140 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC---DLKICDFGLARVTS 215 E + QIL G+ Y+H N++HRD+KP N+LL ++KI DFGL+ S Sbjct: 141 HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFS 200 Query: 216 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 + + + + T +Y APE+L Y DVWS G I L+ P F G++ ++ Sbjct: 201 KDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKK 258 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 + + + + + A +LI+ MLT+D + Sbjct: 259 VEK--------------------------GKYYFDFNDWKNISDEAKELIKLMLTYDYNK 292 Query: 336 RITVLDALAHPYLNSLHD 353 R T +AL ++ + Sbjct: 293 RCTAEEALNSRWIKKYAN 310 >2YCR-A nrPDB Length = 323 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 85/300 (28%), Positives = 136/300 (45%), Gaps = 43/300 (14%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT------LREIKLLRH 116 +G GA G V A +T + VAIK I+ A+ EI++L+ Sbjct: 12 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 71 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILR 175 ++H I+ I++ D YI ELM+ +L + N+ L E C+ + YQ+L Sbjct: 72 LNHPCIIKIKNFFDAE------DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 125 Query: 176 GLKYIHSANVLHRDLKPSNLLLN---ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAP 232 ++Y+H ++HRDLKP N+LL+ +C +KI DFG +++ E+ M T Y AP Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 185 Query: 233 ELL--LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 E+L + ++ Y A+D WS+G I + P F L+ Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK---------------- 229 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 Q+ I + + V A+DL++K+L DP+ R T +AL HP+L Sbjct: 230 ---------DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >4FIE-A nrPDB Length = 423 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 149/337 (44%), Gaps = 39/337 (11%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G P P P+ P E P +SH + + + Y + IG+G+ GIVC Sbjct: 113 GMPEKPPGPRSPQRE--PQRVSHEQFRAALQLVVDPGD-PRSYLDNFIKIGEGSTGIVCI 169 Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFND 139 A + + VA+KK+ + + E+ ++R HEN+V + + ++ Sbjct: 170 ATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG-----DE 222 Query: 140 VYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA 199 +++ E ++ I ++ ++EE +L+ L +H+ V+HRD+K ++LL Sbjct: 223 LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH 282 Query: 200 NCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + +K+ DFG A+V+ E V T ++ APEL+ + Y +D+WS+G + +E++ Sbjct: 283 DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMV 341 Query: 259 DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 D +P + + ++++ + LPP + V Sbjct: 342 DGEPPYFNEPPLKAMKMIRD----------------------NLPPRLKN-----LHKVS 374 Query: 319 PLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P ++++L DP +R T + L HP+L + Sbjct: 375 PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 411 >4JDH-A nrPDB Length = 346 Score = 267 bits (682), Expect = 7e-72, Method: Composition-based stats. Identities = 77/346 (22%), Positives = 149/346 (43%), Gaps = 39/346 (11%) Query: 11 DTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIG 70 G P P P+ P E P +SH + + + Y + IG Sbjct: 27 QGARARQENGMPEKPPGPRSPQRE--PQRVSHEQFRAALQLVVDPGD-PRSYLDNFIKIG 83 Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIP 130 +G+ GIVC A + + VA+KK+ + + E+ ++R HEN+V + + Sbjct: 84 EGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 141 Query: 131 PPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDL 190 +++++ E ++ I ++ ++EE +L+ L +H+ V+HRD+ Sbjct: 142 VG-----DELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 196 Query: 191 KPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWS 249 K ++LL + +K+ DFG A+V+ E V T ++ APEL+ + Y +D+WS Sbjct: 197 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWS 255 Query: 250 VGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQS 309 +G + +E++D +P + + ++++ + LPP + Sbjct: 256 LGIMVIEMVDGEPPYFNEPPLKAMKMIRD----------------------NLPPRLKN- 292 Query: 310 ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 V P ++++L DP +R T + L HP+L + Sbjct: 293 ----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 334 >3I6U-A nrPDB Length = 419 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 92/347 (26%), Positives = 150/347 (43%), Gaps = 50/347 (14%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAK----YKPPIMPIGKGAYG 75 G P I +LS F+ +++ + V K +G GA G Sbjct: 93 GKGKRRPLNNNSEIA---LSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACG 149 Query: 76 IVCSAMNSETNESVAIKKIANAFDNKIDAKRT------LREIKLLRHMDHENIVAIRDII 129 V A +T + VAI+ I+ A+ EI++L+ ++H I+ I++ Sbjct: 150 EVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF 209 Query: 130 PPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 D YI ELM+ +L + N+ L E C+ + YQ+L ++Y+H ++HR Sbjct: 210 DAE------DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHR 263 Query: 189 DLKPSNLLLN---ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL--LNSSDYTA 243 DLKP N+LL+ +C +KI DFG +++ E+ M T Y APE+L + ++ Y Sbjct: 264 DLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNR 323 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 A+D WS+G I + P F L+ Q+ Sbjct: 324 AVDCWSLGVILFICLSGYPPFSEHRTQVSLK-------------------------DQIT 358 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 I + + V A+DL++K+L DP+ R T +AL HP+L Sbjct: 359 SGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >5KCV-A nrPDB Length = 460 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 89/380 (23%), Positives = 156/380 (41%), Gaps = 65/380 (17%) Query: 2 DGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAK 61 DG Q AA+ + F + +PS G E + +L+ ++ + N FE Sbjct: 122 DGLKKQAAAEMD-------FRSGSPSDNS-GAEEMEVSLAKP----KHRVTMNEFEY--- 166 Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLRHMDHE 120 + +GKG +G V T A+K + K + TL E ++L++ H Sbjct: 167 ----LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 222 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 + A++ R F E +L + + SE+ +++ +I+ L Y Sbjct: 223 FLTALKYSFQTHDRLCF-----VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 180 IHS-ANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPELLLN 237 +HS NV++RDLK NL+L+ + +KI DFGL + + M + T Y APE+L + Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 337 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 + DY A+D W +G + E+M + F +DH L++ EE+ F Sbjct: 338 N-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------EEIRFPR----- 384 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHPYLNS-L 351 T+ P A L+ +L DP++R+ + + H + + Sbjct: 385 ------------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 426 Query: 352 HDISDEPECTIPFNFDFENH 371 E + + PF + Sbjct: 427 WQHVYEKKLSPPFKPQVTSE 446 >4CQG-A nrPDB Length = 331 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 91/338 (26%), Positives = 145/338 (42%), Gaps = 47/338 (13%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 ++ KY IG G + V A + T E VAIK + D R EI L+ Sbjct: 4 YDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS-DLPRVKTEIDALK 62 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H++I + ++ N +++ E +L I S LSEE + QIL Sbjct: 63 SLRHQHICQLYHVLETK-----NKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIL 117 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDF-MTEYVVTRWYRAP 232 + Y+HS HRDLKP NLL + N LK+ DFGL A+ D+ + E + Y AP Sbjct: 118 SAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAP 177 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 EL+ S + DVWS+G + LM F + + + +M Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM--------------- 222 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 R ++P + + P +I L+++ML DP++RI++ + L HP++ + Sbjct: 223 ----RGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 Query: 353 DISDEPECTIPFNFDFE--------NHALSEEQMKELI 382 E + P E +H S + M++LI Sbjct: 268 SCPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLI 305 >3F3Z-A nrPDB Length = 277 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 122/295 (41%), Gaps = 39/295 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 +Y IG+G++G V A+ T A KKI F +D R +EI++++ +DH Sbjct: 8 NQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD--RFKQEIEIMKSLDH 65 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + + D+Y+ EL +L + + + E + +L + Sbjct: 66 PNIIRLYETFEDN-----TDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVA 120 Query: 179 YIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y H NV HRDLKP N L + + LK+ DFGLA M V T +Y +P++L Sbjct: 121 YCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVL 180 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y D WS G + L+ P F + + E T E++ Sbjct: 181 --EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKD-------- 230 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + V P A LI ++LT P++RIT L AL H + Sbjct: 231 ------------------WLNVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >4D2V-A nrPDB Length = 356 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 83/318 (26%), Positives = 135/318 (42%), Gaps = 39/318 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 ++ KY IG G + V A + T E VAIK + D R EI+ L+ Sbjct: 24 YDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALK 82 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 ++ H++I + ++ N +++ E +L I S LSEE + QI+ Sbjct: 83 NLRHQHICQLYHVLETA-----NKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIV 137 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDF-MTEYVVTRWYRAP 232 + Y+HS HRDLKP NLL + LK+ DFGL A+ D+ + Y AP Sbjct: 138 SAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 EL+ S + DVWS+G + LM F + +M Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIM--------------- 242 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 R +P + + P +I L+++ML DP++RI++ + L HP++ + Sbjct: 243 ----RGKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 287 Query: 353 DISDEPECTIPFNFDFEN 370 + E + PF ++ Sbjct: 288 NYPVEWQSKNPFIHLDDD 305 >2J90-A nrPDB Length = 304 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 121/303 (39%), Gaps = 41/303 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK----IDAKRTLREIKLLR 115 + +G G + IV T + A K I + + + RE+ +LR Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H NI+ + DI DV + EL+ +L + ++L+E+ FL QIL Sbjct: 85 EIRHPNIITLHDIFENK-----TDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQIL 139 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNA----NCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 G+ Y+HS + H DLKP N++L N +K+ DFG+A + T + Sbjct: 140 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFV 199 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ N D+WS+G I L+ F G L + + Sbjct: 200 APEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV----------- 247 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + F LA D I ++L DP+RR+T+ +L H ++ + Sbjct: 248 ---------------NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKA 292 Query: 351 LHD 353 + Sbjct: 293 IRR 295 >2JAM-A nrPDB Length = 304 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 130/331 (39%), Gaps = 50/331 (15%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 K + +G GA+ V T + A+K I + + + EI +L+ + H Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS--LENEIAVLKKIKH 65 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 ENIV + DI Y+ +L+ +L I +E+ + Q+L +K Sbjct: 66 ENIVTLEDIYESTTHY-----YLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVK 120 Query: 179 YIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y+H ++HRDLKP NLL N + I DFGL++ ++ M+ T Y APE+L Sbjct: 121 YLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVL 179 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y+ A+D WS+G I L+ P F E Sbjct: 180 AQ-KPYSKAVDCWSIGVITYILLCGYPPFY--------------------------EETE 212 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS----L 351 + ++ + + + + A D I +L DP R T AL+HP+++ Sbjct: 213 SKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALH 272 Query: 352 HDISDEPECTIPFNFDFENHALSEEQMKELI 382 DI I NF + + ++ Sbjct: 273 RDIYPSVSLQIQKNFA-------KSKWRQAF 296 >3COM-A nrPDB Length = 314 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 131/300 (43%), Gaps = 40/300 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + +G+G+YG V A++ ET + VAIK++ + D + ++EI +++ D Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCD 82 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR-SNQALSEEHCQYFLYQILRG 176 ++V D++I E + IIR N+ L+E+ L L+G Sbjct: 83 SPHVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKG 137 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV-VTRWYRAPELL 235 L+Y+H +HRD+K N+LLN K+ DFG+A +++ V T ++ APE++ Sbjct: 138 LEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 197 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y D+WS+G +E+ + KP + +H +R + + P Sbjct: 198 QEIG-YNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIFMIPTNPP----------- 242 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P + + D +++ L P +R T L HP++ S +S Sbjct: 243 ----------PTFRKPELW---SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVS 289 >3EB0-A nrPDB Length = 383 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 104/351 (29%), Positives = 177/351 (50%), Gaps = 48/351 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 E ++K +G G++GIVC + E+ + A+KK+ K RE+ +++ Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKV 56 Query: 117 MDHENIVAIRDIIPPPLRNAFND---------------------------------VYIA 143 +DH NI+ + D + + Sbjct: 57 LDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVI 116 Query: 144 YELMDTDLHQ----IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA 199 E + LH+ IRS +++ ++YQ+ R + +IHS + HRD+KP NLL+N+ Sbjct: 117 MEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 200 -NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 + LK+CDFG A+ S+ Y+ +R+YRAPEL+L +++YT +ID+WS+GC+F EL+ Sbjct: 177 KDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI 236 Query: 259 DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 KPLF G + QL +++++GTP++E++ +N + + P + P Sbjct: 237 LGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV--RFPTLKAKDWRKILPEGT 294 Query: 319 P-LAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDF 368 P LAIDL+E++L ++P RI +A+AHP+ + L + S E E NF Sbjct: 295 PSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRN-SYESEVKNNSNFPH 344 >3GUB-A nrPDB Length = 295 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 119/299 (39%), Gaps = 41/299 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK----IDAKRTLREIKLLR 115 Y +G G + +V T A K I + + RE+ +L+ Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H N++ + ++ DV + EL+ +L + ++L+EE FL QIL Sbjct: 70 EIQHPNVITLHEVYENK-----TDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQIL 124 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANC----DLKICDFGLARVTSESDFMTEYVVTRWYR 230 G+ Y+HS + H DLKP N++L +KI DFGLA + T + Sbjct: 125 NGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFV 184 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ N D+WS+G I L+ F G L + + Sbjct: 185 APEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV----------- 232 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + + F LA D I ++L DP++R+T+ D+L HP++ Sbjct: 233 ---------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >2YAB-A nrPDB Length = 361 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 117/299 (39%), Gaps = 41/299 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK----IDAKRTLREIKLLR 115 + +G G + IV T A K I + + RE+ +LR Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H NI+ + D+ DV + EL+ +L + ++LSEE F+ QIL Sbjct: 71 QVLHPNIITLHDVYE-----NRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANC----DLKICDFGLARVTSESDFMTEYVVTRWYR 230 G+ Y+H+ + H DLKP N++L +K+ DFGLA + T + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFV 185 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ N D+WS+G I L+ F G L + + Sbjct: 186 APEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV----------- 233 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + F LA D I K+L + R+R+T+ +AL HP++ Sbjct: 234 ---------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >6C9D-A nrPDB Length = 459 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 37/307 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IGKG + V A + T VA+K I N ++ RE+++++ ++H NIV + Sbjct: 27 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 86 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 ++I +Y+ E ++ + ++ + E+ + QI+ ++Y H + Sbjct: 87 EVIETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 141 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 +HRDLK NLLL+ + ++KI DFG + + + + E+ + Y APEL + Sbjct: 142 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEV 201 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+G I L+ F G++ L+ L E R ++P Y Sbjct: 202 DVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKYRIPFY 242 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 + + L P +R ++ + ++N H+ + T P + Sbjct: 243 MSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-D 290 Query: 366 FDFENHA 372 DF + Sbjct: 291 PDFNDTK 297 >2HAK-A nrPDB Length = 328 Score = 258 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 129/307 (42%), Gaps = 37/307 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 IGKG + V A + T VA+K I N ++ RE+++++ ++H NIV + Sbjct: 21 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 80 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 ++I +Y+ E ++ + ++ + E+ + QI+ ++Y H + Sbjct: 81 EVIETE-----KTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 135 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 +HRDLK NLLL+ + ++KI DFG + + + + + + Y APEL + Sbjct: 136 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 195 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+G I L+ F G++ L+ L E R ++P Y Sbjct: 196 DVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKYRIPFY 236 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 + + L P +R ++ + ++N H+ + T P + Sbjct: 237 MSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEEELKPYTEP-D 284 Query: 366 FDFENHA 372 DF + Sbjct: 285 PDFNDTK 291 >2F57-A nrPDB Length = 317 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 75/335 (22%), Positives = 150/335 (44%), Gaps = 41/335 (12%) Query: 38 ATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA 97 + +SH + + + +Y + IG+G+ GIVC A T + VA+KK+ Sbjct: 23 SRVSHEQFRAALQLVVSPGD-PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD-- 79 Query: 98 FDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS 157 + + E+ ++R H+N+V + +++++ E ++ I + Sbjct: 80 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVG-----DELWVVMEFLEGGALTDIVT 134 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSE 216 + ++EE +LR L Y+H+ V+HRD+K ++LL ++ +K+ DFG A+V+ E Sbjct: 135 HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKE 194 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 V T ++ APE++ + Y +D+WS+G + +E++D +P + + +R + Sbjct: 195 VPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRI 253 Query: 277 MELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + LPP + V + ++ ML +P +R Sbjct: 254 RD----------------------SLPPRVKD-----LHKVSSVLRGFLDLMLVREPSQR 286 Query: 337 ITVLDALAHPYLNSLHDISDEPECTIPFNFDFENH 371 T + L HP+L ++ P C +P + +H Sbjct: 287 ATAQELLGHPFLK----LAGPPSCIVPLMRQYRHH 317 >2Y7J-A nrPDB Length = 365 Score = 257 bits (656), Expect = 8e-69, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 130/306 (42%), Gaps = 45/306 (14%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN------KIDAKRTLRE 110 E KY P IG+G +V ++ T A+K + + + + T RE Sbjct: 91 EFYQKYDPK-DVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRE 149 Query: 111 IKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQY 168 +LR + H +I+ + D ++ ++LM +L + ALSE+ + Sbjct: 150 THILRQVAGHPHIITLIDSYESSSFM-----FLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 + +L + ++H+ N++HRDLKP N+LL+ N +++ DFG + + + E T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 229 YRAPELLLNS-----SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 Y APE+L S Y +D+W+ G I L+ P F R + LR++ME Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME----- 319 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 +Y P + + DLI ++L DP R+T AL Sbjct: 320 ------------GQYQFSSPEWDDR---------SSTVKDLISRLLQVDPEARLTAEQAL 358 Query: 344 AHPYLN 349 HP+ Sbjct: 359 QHPFFE 364 >2W4O-A nrPDB Length = 349 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 132/323 (40%), Gaps = 44/323 (13%) Query: 33 IENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK 92 P T S Y I G+ + + + +G+GA IV T + A+K Sbjct: 28 ASAAPGTAS---LVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALK 84 Query: 93 KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDL 151 + D KI EI +L + H NI+ +++I P ++ + EL+ +L Sbjct: 85 VLKKTVDKKI----VRTEIGVLLRLSHPNIIKLKEIFETP-----TEISLVLELVTGGEL 135 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDF 208 I SE + QIL + Y+H ++HRDLKP NLL + LKI DF Sbjct: 136 FDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADF 195 Query: 209 GLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR-KPLFPGR 267 GL+++ M T Y APE+L + Y +D+WSVG I L+ +P + R Sbjct: 196 GLSKIVEHQVLMKTVCGTPGYCAPEILRGCA-YGPEVDMWSVGIITYILLCGFEPFYDER 254 Query: 268 DHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 R ++ I+ + V A DL+ K Sbjct: 255 GDQFMFRRILNC--------------------------EYYFISPWWDEVSLNAKDLVRK 288 Query: 328 MLTFDPRRRITVLDALAHPYLNS 350 ++ DP++R+T AL HP++ Sbjct: 289 LIVLDPKKRLTTFQALQHPWVTG 311 >5XZW-A nrPDB Length = 471 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 47/316 (14%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 ++ N + + +G+GA+ V A+ T ++ A+K I+ + Sbjct: 183 ASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI-GNMDGV 241 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHC 166 RE+++L+ ++H IV ++ Y+ E + DL + ++ A+ E+ Sbjct: 242 TRELEVLQKLNHPRIVRLKGFYEDTESY-----YMVMEFVSGGDLMDFVAAHGAVGEDAG 296 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYV 224 + QIL +KYIHS + HRDLKP N+L+ + +KI DFGLA+V FM + Sbjct: 297 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFC 356 Query: 225 VTRWYRAPELLLN------------SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 T Y APE++ ++Y++ +D+WS+GC+ ++ F G Sbjct: 357 GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQL 416 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 + + G+ E L+ + A D I+ +L D Sbjct: 417 YKQIGR--GSYHEGPLKDF------------------------RISEEARDFIDSLLQVD 450 Query: 333 PRRRITVLDALAHPYL 348 P R T AL HP++ Sbjct: 451 PNNRSTAAKALNHPWI 466 >5WAX-A nrPDB Length = 310 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 120/294 (40%), Gaps = 38/294 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 +Y+ + IG G +G+ N + VA+K I KID + REI R + Sbjct: 10 GDRYEL-VRDIGSGNFGVARLMRNRADGQLVAVKYIERG--EKID-ENVQREIINHRSLR 65 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NI+ +++I P A I E +L + I + SE+ ++F Q++ G+ Sbjct: 66 HPNIIRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 178 KYIHSANVLHRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y HS V HRDLK N LL+ + LKICDFG ++ + V T Y APE+L Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL-LMELIGTPSEEELEFLNEN 294 L DVWS G ++ F D R + ++G Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV------------ 228 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 Q + + P DLI ++ +P RIT+ + HP+ Sbjct: 229 -------------QYSIPDYVHISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >1PHK-A nrPDB Length = 298 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 127/305 (41%), Gaps = 45/305 (14%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT-------LREIKL 113 + P +G+G +V ++ T + A+K I A+ L+E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 114 LRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLY 171 LR + H NI+ ++D ++ ++LM +L + LSE+ + + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTF-----FFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 +L + +H N++HRDLKP N+LL+ + ++K+ DFG + + + E T Y A Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLA 191 Query: 232 PELLL-----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 PE++ N Y +D+WS G I L+ P F R + LR++M Sbjct: 192 PEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM--------- 242 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 346 Q + ++ DL+ + L P++R T +ALAHP Sbjct: 243 -----------------SGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHP 285 Query: 347 YLNSL 351 + Sbjct: 286 FFQQY 290 >5Y86-A nrPDB Length = 588 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 96/328 (29%), Positives = 158/328 (48%), Gaps = 50/328 (15%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE- 120 + IGKG++G V + + + VA+K + N K ++ EI++L H+ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN---EKRFHRQAAEEIRILEHLKKQD 264 Query: 121 -----NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQI 173 N++ + + N V +A+EL+ DL+++I+ N Q S + + F I Sbjct: 265 KTGSMNVIHMLESFT-----FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRA 231 L+ L +H ++H DLKP N+LL + K+ DFG + E + Y+ +R+YRA Sbjct: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRA 377 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE-- 289 PE++L S Y+ ID+WS GCI EL+ +PLFPG D QL +MEL+G P + LE Sbjct: 378 PEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 Query: 290 -----FLNENA----------------------KRYIRQLPPYPRQSITDKFPTVHPLAI 322 F+N +R ++ PP + T L I Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 323 DLIEKMLTFDPRRRITVLDALAHPYLNS 350 + +++ L +DP R+T AL HP+++ Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 >2A27-A nrPDB Length = 321 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 125/320 (39%), Gaps = 48/320 (15%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK- 101 G + + +++ + +G G + IV T A K I Sbjct: 1 GMEPFKQQKVEDFYDIGEE-------LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRAS 53 Query: 102 ---IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS 157 + + RE+ +LR + H N++ + D+ DV + EL+ +L + Sbjct: 54 RRGVSREEIEREVSILRQVLHHNVITLHDVYE-----NRTDVVLILELVSGGELFDFLAQ 108 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC----DLKICDFGLARV 213 ++LSEE F+ QIL G+ Y+H+ + H DLKP N++L +K+ DFGLA Sbjct: 109 KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE 168 Query: 214 TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 + T + APE++ N D+WS+G I L+ F G L Sbjct: 169 IEDGVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETL 227 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 + + + F LA D I K+L + Sbjct: 228 ANITAV--------------------------SYDFDEEFFSQTSELAKDFIRKLLVKET 261 Query: 334 RRRITVLDALAHPYLNSLHD 353 R+R+T+ +AL HP++ + + Sbjct: 262 RKRLTIQEALRHPWITPVDN 281 >4LG4-A nrPDB Length = 299 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 130/300 (43%), Gaps = 40/300 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + +G+G+YG V A++ E+ + VAIK++ + D + ++EI +++ D Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCD 64 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR-SNQALSEEHCQYFLYQILRG 176 +V D++I E + IIR N+ L E+ L L+G Sbjct: 65 SPYVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKG 119 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV-VTRWYRAPELL 235 L+Y+H +HR++K N+LLN K+ DFG+A +++ V T ++ APE++ Sbjct: 120 LEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 179 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y D+WS+G +E+ + KP + +H +R + + P Sbjct: 180 QEIG-YNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPP----------- 224 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P + + D ++K L +P +R T L HP++ + +S Sbjct: 225 ----------PTFRKPELW---SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVS 271 >3DB8-A nrPDB Length = 317 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 92/372 (24%), Positives = 152/372 (40%), Gaps = 65/372 (17%) Query: 3 GGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSH--GGRFIQYNIFGNIFEVTA 60 G A + P +AP ++P + P T+ GRF Sbjct: 4 GSMSAAIAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRF-------------- 49 Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDH 119 +GKG + + +T E A K + + K K + EI + + +D+ Sbjct: 50 --------LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLK 178 ++V VY+ E+ L ++ + +A++E +YF+ Q ++G++ Sbjct: 102 PHVVGFHGFFEDDDF-----VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQ 156 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLN 237 Y+H+ V+HRDLK NL LN + D+KI DFGLA ++ + + + T Y APE+L Sbjct: 157 YLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL-C 215 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 ++ +D+WS+GCI L+ KP F E L E R Sbjct: 216 KKGHSFEVDIWSLGCILYTLLVGKPPF----------------------ETSCLKETYIR 253 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDE 357 + PR ++P+A LI +ML DP R +V + L + S + Sbjct: 254 IKKNEYSVPR--------HINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRL 305 Query: 358 PEC--TIPFNFD 367 P T+P F Sbjct: 306 PTSCLTVPPRFS 317 >1ZWS-A nrPDB Length = 288 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 125/320 (39%), Gaps = 48/320 (15%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK- 101 G + + +++ + +G G + IV T A K I Sbjct: 1 GMEPFKQQKVEDFYDIGEE-------LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRAS 53 Query: 102 ---IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS 157 + + RE+ +LR + H N++ + D+ DV + EL+ +L + Sbjct: 54 RRGVSREEIEREVSILRQVLHHNVITLHDVYE-----NRTDVVLILELVSGGELFDFLAQ 108 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC----DLKICDFGLARV 213 ++LSEE F+ QIL G+ Y+H+ + H DLKP N++L +K+ DFGLA Sbjct: 109 KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE 168 Query: 214 TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 + T + APE++ N D+WS+G I L+ F G L Sbjct: 169 IEDGVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETL 227 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 + + + F LA D I K+L + Sbjct: 228 ANITSV--------------------------SYDFDEEFFSHTSELAKDFIRKLLVKET 261 Query: 334 RRRITVLDALAHPYLNSLHD 353 R+R+T+ +AL HP++ + + Sbjct: 262 RKRLTIQEALRHPWITPVDN 281 >5JZN-A nrPDB Length = 280 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 131/314 (41%), Gaps = 39/314 (12%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 G + F +T +YK IG G + +V + T A+K I + Sbjct: 1 GSGEEVSEEGFQIPATITERYKVG-RTIGDGNFAVVKECVERSTAREYALKIIKKSKCRG 59 Query: 102 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA 160 + E+ +LR + H NIV + + + P ++Y+ EL+ DL I S Sbjct: 60 KEHM-IQNEVSILRRVKHPNIVLLIEEMDVP-----TELYLVMELVKGGDLFDAITSTNK 113 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NANCDLKICDFGLARVTSE 216 +E LY + +KY+HS N++HRD+KP NLL+ + + LK+ DFGLA + Sbjct: 114 YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-- 171 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 + T Y APE++ + Y +D+W+ G I L+ P F G Sbjct: 172 DGPLYTVCGTPTYVAPEIIAETG-YGLKVDIWAAGVITYILLCGFPPFRG---------- 220 Query: 277 MELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 S ++ E L + P + + V A +LI ML D +R Sbjct: 221 -------SGDDQEVLFDQILMGQVDFP-------SPYWDNVSDSAKELITMMLLVDVDQR 266 Query: 337 ITVLDALAHPYLNS 350 + + L HP++N Sbjct: 267 FSAVQVLEHPWVND 280 >4XBR-A nrPDB Length = 366 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 145/328 (44%), Gaps = 39/328 (11%) Query: 29 QMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES 88 + P E P +SH + + + Y + IG+G+ GIVC A + + Sbjct: 65 RSPQRE--PQRVSHEQFRAALQLVVDPGD-PRSYLDNFIKIGEGSTGIVCIATVRSSGKL 121 Query: 89 VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD 148 VA+KK+ + + E+ ++R HEN+V + + +++++ E ++ Sbjct: 122 VAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG-----DELWVVMEFLE 174 Query: 149 TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 208 I ++ ++EE +L+ L +H+ V+HRD+K ++LL + +K+ DF Sbjct: 175 GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDF 234 Query: 209 GL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGR 267 G A+V+ E V T ++ APEL+ + Y +D+WS+G + +E++D +P + Sbjct: 235 GFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE 293 Query: 268 DHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 + ++++ + LPP + V P +++ Sbjct: 294 PPLKAMKMIRD----------------------NLPPRLKN-----LHKVSPSLKGFLDR 326 Query: 328 MLTFDPRRRITVLDALAHPYLNSLHDIS 355 +L DP +R T + L HP+L + Sbjct: 327 LLVRDPAQRATAAELLKHPFLAKAGPPA 354 >6AO5-A nrPDB Length = 362 Score = 253 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 130/300 (43%), Gaps = 40/300 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + +G+G+YG V A++ E+ + VAIK++ + D + ++EI +++ D Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCD 63 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR-SNQALSEEHCQYFLYQILRG 176 +V D++I E + IIR N+ L E+ L L+G Sbjct: 64 SPYVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKG 118 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV-VTRWYRAPELL 235 L+Y+H +HR++K N+LLN K+ DFG+A +++ V T ++ APE++ Sbjct: 119 LEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI 178 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 Y D+WS+G +E+ + KP + +H +R + + P Sbjct: 179 QEIG-YNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPP----------- 223 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P + + D ++K L +P +R T L HP++ + +S Sbjct: 224 ----------PTFRKPELW---SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVS 270 >2Q0N-A nrPDB Length = 301 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 144/327 (44%), Gaps = 39/327 (11%) Query: 30 MPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV 89 P E P +SH + + + Y + IG+G+ GIVC A + + V Sbjct: 1 SPQRE--PQRVSHEQFRAALQLVVDPGD-PRSYLDNFIKIGEGSTGIVCIATVRSSGKLV 57 Query: 90 AIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT 149 A+KK+ + + E+ ++R HEN+V + + +++++ E ++ Sbjct: 58 AVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG-----DELWVVMEFLEG 110 Query: 150 DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 I ++ ++EE +L+ L +H+ V+HRD+K ++LL + +K+ DFG Sbjct: 111 GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG 170 Query: 210 L-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD 268 A+V+ E V T ++ APEL+ + Y +D+WS+G + +E++D +P + Sbjct: 171 FCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEP 229 Query: 269 HVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKM 328 + ++++ + LPP + V P ++++ Sbjct: 230 PLKAMKMIRD----------------------NLPPRLKN-----LHKVSPSLKGFLDRL 262 Query: 329 LTFDPRRRITVLDALAHPYLNSLHDIS 355 L DP +R T + L HP+L + Sbjct: 263 LVRDPAQRATAAELLKHPFLAKAGPPA 289 >4D28-A nrPDB Length = 446 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 77/297 (25%), Positives = 128/297 (43%), Gaps = 39/297 (13%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK-IDAKRTLREIKLLRHMDH 119 KY+ IG+G + V A N++T ++VAIK +A + K + REI +++ + H Sbjct: 10 KYEVG-RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NIV + +++ + +YI E + +L I L E+ + + Q++ + Sbjct: 69 PNIVRLYEVLASKSK-----IYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVA 123 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLN 237 + HS V HRDLKP NLLL+ N +LK+ DFGL+ + E + + + T Y APE+L Sbjct: 124 HCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSG 183 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 +A D+WS G I ++ F SE +L L Sbjct: 184 QGYDGSAADIWSCGVILFVILAGYLPF-------------------SETDLPGLYRKINA 224 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 PP+ LI ++L +P+ RI + P+ + Sbjct: 225 AEFDCPPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >6FDY-U nrPDB Length = 276 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 81/293 (27%), Positives = 129/293 (44%), Gaps = 37/293 (12%) Query: 67 MPIGKGAYGIVCSAM-NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G G Y V A +T E VAIK +A NK + L EI++L+ + H +IV + Sbjct: 17 ERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQL 76 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 +D +++Y+ E DL + I + + L E+ + F+ Q+ L+++H N Sbjct: 77 KDFQWDS-----DNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERN 131 Query: 185 VLHRDLKPSNLLLN--ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 242 + H DLKP N+LL+ LK+ DFG A+ S D + Y APE++ Y Sbjct: 132 ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ-YD 190 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 A +D+WS+G I E + +P F R + Sbjct: 191 ARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRS------------------------ 226 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 R P + DL++++L DP RRI+ D AHP+++ H S Sbjct: 227 ---NRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >3TAC-A nrPDB Length = 361 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 77/296 (26%), Positives = 124/296 (41%), Gaps = 45/296 (15%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAF---DNKIDAKRTLREIKLLRHMDHENIV 123 IGKG + +V +N ET + A+K + A + + RE + + H +IV Sbjct: 32 EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIV 91 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDT-DL-HQIIRSNQA---LSEEHCQYFLYQILRGLK 178 + + +Y+ +E MD DL +I++ A SE +++ QIL L+ Sbjct: 92 ELLETYSSD-----GMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALR 146 Query: 179 YIHSANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTE-YVVTRWYRAPEL 234 Y H N++HRD+KP +LL + + +K+ FG+A ES + V T + APE+ Sbjct: 147 YCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEV 206 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y +DVW G I L+ F G Sbjct: 207 V-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE------------------------- 240 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 R + + ++ + A DL+ +ML DP RITV +AL HP+L Sbjct: 241 --RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >2OU7-A nrPDB Length = 335 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 88/319 (27%), Positives = 140/319 (43%), Gaps = 41/319 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIRD 127 +GKG + +++T E A K + + K + + EI + R + H+++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 V++ EL L ++ + +AL+E +Y+L QI+ G +Y+H V+ Sbjct: 109 FFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLK NL LN + ++KI DFGLA +V + + T Y APE+L + ++ + Sbjct: 164 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 222 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+GCI L+ KP F E L E R + Sbjct: 223 DVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIKKNEYSI 260 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC--TIP 363 P+ ++P+A LI+KML DP R T+ + L + S + + P TIP Sbjct: 261 PK--------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIP 312 Query: 364 FNFDFENHALSEEQMKELI 382 F +L K L Sbjct: 313 PRFSIAPSSLDPSNRKPLT 331 >6FD3-A nrPDB Length = 300 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 136/312 (43%), Gaps = 37/312 (11%) Query: 39 TLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF 98 +++ + ++ + KY IG+GA G V +A++ T + VAIK++ Sbjct: 1 SMTDEEILEKLRSIVSVGDPKKKYTRF-EKIGQGASGTVYTALDIATGQEVAIKQMNLQQ 59 Query: 99 DNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN 158 K + + EI ++R + NIV D +++++ E + + + Sbjct: 60 QPKKEL--IINEILVMRENKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLTDVVTE 112 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSES 217 + E + L+ L ++HS V+HRD+K N+LL + +K+ DFG A++T E Sbjct: 113 TCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ 172 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 + V T ++ APE++ Y +D+WS+G + +E+++ +P + + + L L+ Sbjct: 173 SKRSTMVGTPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 231 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 GTP + E L + D + + L D RR Sbjct: 232 -TNGTPELQNPERL--------------------------SAVFRDFLNRCLEMDVDRRG 264 Query: 338 TVLDALAHPYLN 349 + + L HP+L Sbjct: 265 SAKELLQHPFLK 276 >4NIF-A nrPDB Length = 333 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 132/305 (43%), Gaps = 43/305 (14%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G+ + Y IG G+Y ++ TN A+K I + + + EI+ Sbjct: 1 GSNLVFSDGYVVK-ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIE 53 Query: 113 LL-RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 +L R+ H NI+ ++D+ VY+ ELM +L I + SE + L Sbjct: 54 ILLRYGQHPNIITLKDVYDDG-----KHVYLVTELMRGGELLDKILRQKFFSEREASFVL 108 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLL-LNANCD---LKICDFGLARVT-SESDFMTEYVV 225 + I + ++Y+HS V+HRDLKPSN+L ++ + + L+ICDFG A+ +E+ + Sbjct: 109 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY 168 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 T + APE+L Y D+WS+G + ++ F Sbjct: 169 TANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANG------------------ 209 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 ++ + + ++ + TV A DL+ KML DP +R+T L H Sbjct: 210 -----PSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQH 264 Query: 346 PYLNS 350 P++ Sbjct: 265 PWVTQ 269 >4CZT-A nrPDB Length = 464 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 132/332 (39%), Gaps = 48/332 (14%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDH 119 KY+ +G+G + V A N E ++VAIK I + REI ++ + H Sbjct: 12 KYELG-RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 70 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 N++ + +++ + +Y E + +L I SN L E+ + + Q++ + Sbjct: 71 PNVIRMFEVMASKTK-----IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELL 235 Y HS V HRDLKP NLLL+AN LK+ DFGL+ + E + T Y APE++ Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 N A D+WS G I LM F + + + + T Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP----------- 234 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P A LI+++L +P RIT + + + + + Sbjct: 235 -------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAP 275 Query: 356 D-------EPECTIPFNFDFENHALSEEQMKE 380 + F+ E+ L E+ +E Sbjct: 276 KFENADVSLDDVDAIFDDSGESKNLVVERREE 307 >4KS7-A nrPDB Length = 292 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 134/302 (44%), Gaps = 40/302 (13%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 IG+G+ GIVC A + VA+K + + + E+ ++R H N+V + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQHFNVVEMY- 86 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187 ++++ E + I S L+EE +L+ L Y+H+ V+H Sbjct: 87 ----KSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 188 RDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 RD+K ++LL + +K+ DFG A+++ + V T ++ APE++ + S Y +D Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVD 201 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 +WS+G + +E++D +P + V + KR PP Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAM----------------------KRLRDSPPPKL 239 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNF 366 + S V P+ D +E+ML DP+ R T + L HP+L + PEC +P Sbjct: 240 KNS-----HKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ----TGLPECLVPLIQ 290 Query: 367 DF 368 + Sbjct: 291 LY 292 >5J5T-A nrPDB Length = 370 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 84/365 (23%), Positives = 140/365 (38%), Gaps = 60/365 (16%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + I IG G YG V A N T E AIK I +EI +++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCK 59 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIVA + ++I E L I LSE Y + L+GL Sbjct: 60 HPNIVAYFGSY-----LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGL 114 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPEL-- 234 Y+HS +HRD+K +N+LL N +K+ DFG+ A++T+ ++ T ++ APE+ Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y D+W+VG +EL + +P + L L+ + P + Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPK--------- 225 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS---- 350 ++ + ++ LT +P++R T L HP++ Sbjct: 226 ----LKDKMKW------------SNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR 269 Query: 351 -----------------LHDISD---EPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 HD D EP +P + + EE+ + I + F+ Sbjct: 270 SLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFD 329 Query: 391 PEYQQ 395 P ++ Sbjct: 330 PPLRK 334 >5ZTN-A nrPDB Length = 429 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 91/321 (28%), Positives = 154/321 (47%), Gaps = 38/321 (11%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 + IGKG++G V A + + ++ VA+K + N A +R ++ LR D +N Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKY 179 + + ++ N + + +EL+ +L+++I+ N Q S + F + IL+ L Sbjct: 158 TMNVIHMLENFTFR--NHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDA 215 Query: 180 IHSANVLHRDLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN 237 +H ++H DLKP N+LL +K+ DFG + E + Y+ +R+YRAPE++L Sbjct: 216 LHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC--YEHQRVYTYIQSRFYRAPEVILG 273 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE---- 293 + Y ID+WS+GCI EL+ PL PG D QL ++EL+G PS++ L+ Sbjct: 274 AR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNF 332 Query: 294 -------------------------NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKM 328 ++R + PP R+ PL +D +++ Sbjct: 333 VSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQC 392 Query: 329 LTFDPRRRITVLDALAHPYLN 349 L +DP R+T AL HP+L Sbjct: 393 LEWDPAVRMTPGQALRHPWLR 413 >4PDS-A nrPDB Length = 347 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 133/317 (41%), Gaps = 47/317 (14%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 ++ N + + +G+GA+ V A+ T ++ ++K I+ + Sbjct: 18 ASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVI-GNMDGV 76 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHC 166 RE+++L+ ++H IV ++ Y+ E + DL + ++ A+ E+ Sbjct: 77 TRELEVLQKLNHPRIVRLKGFYEDTESY-----YMVMEFVSGGDLMDFVAAHGAVGEDAG 131 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD--LKICDFGLARVTSESDFMTEYV 224 + QIL +KYIHS + HRDLKP N+L+ + +KI FGLA+V FM + Sbjct: 132 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFC 191 Query: 225 VTRWYRAPELLLN------------SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 T Y APE++ ++Y++ +D+WS+GC+ ++ F G Sbjct: 192 GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQL 251 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 + + G+ E L+ + A D I+ +L D Sbjct: 252 YKQIGR--GSYHEGPLKDF------------------------RISEEARDFIDSLLQVD 285 Query: 333 PRRRITVLDALAHPYLN 349 P R T AL HP++ Sbjct: 286 PNNRSTAAKALNHPWIK 302 >2HW6-A nrPDB Length = 307 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 122/313 (38%), Gaps = 35/313 (11%) Query: 55 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 + YK +G+GAY V A++ + + A+K I + R RE++ L Sbjct: 7 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS--RVFREVETL 64 Query: 115 RHMD-HENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQ 172 ++NI+ + + R Y+ +E L + I+ + +E + Sbjct: 65 YQCQGNKNILELIEFFEDDTR-----FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRD 119 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNAN---CDLKICDFGLARVTS--------ESDFMT 221 + L ++H+ + HRDLKP N+L + +KICDF L + +T Sbjct: 120 VAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELT 179 Query: 222 EYVVTRWYRAPELLL----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 + Y APE++ ++ Y D+WS+G + ++ P F G Sbjct: 180 TPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRG 239 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 E+ + E + E + + + A DLI K+L D ++R+ Sbjct: 240 EVCRVCQNKLFESIQE-----------GKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL 288 Query: 338 TVLDALAHPYLNS 350 + L HP++ Sbjct: 289 SAAQVLQHPWVQG 301 >3ZUT-A nrPDB Length = 362 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 119/293 (40%), Gaps = 35/293 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IG G +G+ + ++NE VA+K I KID + REI R + Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG--EKID-ENVKREIINHRSLR 73 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV +++I P A I E +L + I + SE+ ++F Q++ G+ Sbjct: 74 HPNIVRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 178 KYIHSANVLHRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y H+ V HRDLK N LL+ + LKIC FG ++ + V T Y APE+L Sbjct: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 L DVWS G ++ F EE + + Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFE------------------DPEEPKNFRKTI 230 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 R + P + + P LI ++ DP +RI++ + H + Sbjct: 231 HRILNVQYAIP------DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2JDO-A nrPDB Length = 342 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 75/325 (23%), Positives = 138/325 (42%), Gaps = 45/325 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLR 115 +VT + +GKG +G V T A+K + K + T+ E ++L+ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H + A++ R F E +L + + +EE +++ +I+ Sbjct: 66 NTRHPFLTALKYAFQTHDRLCF-----VMEYANGGELFFHLSRERVFTEERARFYGAEIV 120 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPE 233 L+Y+HS +V++RD+K NL+L+ + +KI DFGL + S+ M + T Y APE Sbjct: 121 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE 180 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L ++ DY A+D W +G + E+M + F +DH L++ EE+ F Sbjct: 181 VLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM-------EEIRFPR- 231 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHPYL 348 T+ P A L+ +L DP++R+ + + H + Sbjct: 232 ----------------------TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 Query: 349 NSLH-DISDEPECTIPFNFDFENHA 372 S++ + + PF + Sbjct: 270 LSINWQDVVQKKLLPPFKPQVTSEV 294 >3UC3-A nrPDB Length = 361 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 114/293 (38%), Gaps = 35/293 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IG G +G+ + T E VA+K I + REI R + Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID---ENVQREIINHRSLR 74 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV +++I P A I E +L++ I + SE+ ++F Q+L G+ Sbjct: 75 HPNIVRFKEVILTPTHLA-----IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGV 129 Query: 178 KYIHSANVLHRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y HS + HRDLK N LL+ + LKICDFG ++ + V T Y APE+L Sbjct: 130 SYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 L DVWS G ++ F EE + Sbjct: 190 LRQEYDGKIADVWSCGVTLYVMLVGAYPFE------------------DPEEPRDYRKTI 231 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 +R + P + P LI ++ DP RI++ + H + Sbjct: 232 QRILSVKYSIPDDI------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >3D2K-A nrPDB Length = 272 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 70/286 (24%), Positives = 123/286 (43%), Gaps = 39/286 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 P+GKG +G V A ++ +A+K + K + LR E+++ H+ H NI+ + Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRL 77 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 R VY+ E +++ ++ E+ ++ ++ L Y HS Sbjct: 78 YGYFHDATR-----VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKR 132 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 V+HRD+KP NLLL +N +LKI DFG + V + S T T Y PE++ + Sbjct: 133 VIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEG-RMHDEK 190 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+WS+G + E + P F + R + + T + Sbjct: 191 VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPD------------------- 231 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 V A DLI ++L + +R+T+ + L HP++ + Sbjct: 232 -----------FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKA 266 >4B6L-A nrPDB Length = 281 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 80/303 (26%), Positives = 123/303 (40%), Gaps = 39/303 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI-DAKRTLREIKLLRHM 117 + + +GKG + A ++ET + A+K I + K ++ L EI+L R + Sbjct: 7 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 66 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRG 176 H +IV +++YI EL L I ++ L E +Y+L QIL G Sbjct: 67 QHRHIVRFSHHFEDA-----DNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSG 121 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELL 235 LKY+H +LHRDLK N + N +LK+ DFGLA R+ T Y APE+L Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 L + DVWS+GC+ L+ P F D R + ++ T Sbjct: 182 L-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPA---------- 230 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 ++ A L+ +L PR R ++ L H + + Sbjct: 231 --------------------SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPD 270 Query: 356 DEP 358 P Sbjct: 271 RLP 273 >2X4F-A nrPDB Length = 373 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 84/381 (22%), Positives = 140/381 (36%), Gaps = 50/381 (13%) Query: 2 DGGSGQPAADTEMTEAPGGFPAAAP--SPQMP----GIENIPATLSHGGRFIQYNIFGNI 55 D S + + + P S + I PA H + + Sbjct: 29 DQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSF 88 Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 + V+ +G G +G V + T +A K I D + EI ++ Sbjct: 89 YTVS-----KTEILGGGRFGQVHKCEETATGLKLAAKIIK--TRGMKDKEEVKNEISVMN 141 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQ-IIRSNQALSEEHCQYFLYQI 173 +DH N++ + D ND+ + E +D +L II + L+E F+ QI Sbjct: 142 QLDHANLIQLYDAFESK-----NDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQI 196 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 G++++H +LH DLKP N+L +KI DFGLAR + + T + A Sbjct: 197 CEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLA 256 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE++ N + D+WSVG I L+ F G + L ++ +EE + Sbjct: 257 PEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQ-- 313 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + A + I K+L + RI+ +AL HP+L+ Sbjct: 314 ------------------------DISEEAKEFISKLLIKEKSWRISASEALKHPWLSD- 348 Query: 352 HDISDEPECTIPFNFDFENHA 372 H + N + Sbjct: 349 HKLHSRLSAQKKKNRGSDAQD 369 >3IS5-A nrPDB Length = 285 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 130/318 (40%), Gaps = 50/318 (15%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 S ++F +G GA+G V + IK I + Sbjct: 9 SGRENLYFQGTIDDLFIFK-------RKLGSGAFGDVHLVEERSSGLERVIKTINKD-RS 60 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRS-- 157 ++ ++ EI++L+ +DH NI+ I ++ ++++YI E + +L + I S Sbjct: 61 QVPMEQIEAEIEVLKSLDHPNIIKIFEVFED-----YHNMYIVMETCEGGELLERIVSAQ 115 Query: 158 --NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLAR 212 +ALSE + + Q++ L Y HS +V+H+DLKP N+L + +KI DFGLA Sbjct: 116 ARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAE 175 Query: 213 VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 + + T T Y APE+ D T D+WS G + L+ F G Sbjct: 176 LFKSDEHSTNAAGTALYMAPEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEE- 232 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 ++Q Y + + + P A+DL+++MLT D Sbjct: 233 --------------------------VQQKATYKEPNYAVECRPLTPQAVDLLKQMLTKD 266 Query: 333 PRRRITVLDALAHPYLNS 350 P RR + L H + Sbjct: 267 PERRPSAAQVLHHEWFKQ 284 >3KN6-A nrPDB Length = 325 Score = 246 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 138/302 (45%), Gaps = 36/302 (11%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAI 125 P+G+G++ I ++ ++N++ A+K I+ + T +EI L+ + H NIV + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKL 71 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 ++ L ++ EL+ +L + I+ + SE Y + +++ + ++H Sbjct: 72 HEVFHDQLHT-----FLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 126 Query: 185 VLHRDLKPSNLLL---NANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSD 240 V+HRDLKP NLL N N ++KI DFG AR+ ++ + T Y APE LLN + Sbjct: 127 VVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNG 185 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 Y + D+WS+G I ++ + F D +E++ + + F E Sbjct: 186 YDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGE------- 238 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC 360 + V A DLI+ +LT DP +R+ + + +L +S P Sbjct: 239 ------------AWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 286 Query: 361 TI 362 T Sbjct: 287 TP 288 >3MV5-A nrPDB Length = 342 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 80/348 (22%), Positives = 140/348 (40%), Gaps = 47/348 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLR 115 VT + +GKG +G V T A+K + K + TL E ++L+ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 + H + A++ R F E +L + + SE+ +++ +I+ Sbjct: 66 NSRHPFLTALKYSFQTHDRLCF-----VMEYANGGELFFHLSRERVFSEDRARFYGAEIV 120 Query: 175 RGLKYIHS-ANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAP 232 L Y+HS NV++RDLK NL+L+ + +KI DFGL + + M + T Y AP Sbjct: 121 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 180 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 E+L ++ DY A+D W +G + E+M + F +DH L++ EE+ F Sbjct: 181 EVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------EEIRFPR 232 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHPY 347 T+ P A L+ +L DP++R+ + + H + Sbjct: 233 -----------------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 269 Query: 348 LNS-LHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 + E + + PF + + E + + P Q Sbjct: 270 FAGIVWQHVYEKKLSPPFKPQVTSETDTRY-FDEEFTAQMITITPPDQ 316 >4UZD-A nrPDB Length = 287 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 70/286 (24%), Positives = 123/286 (43%), Gaps = 39/286 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 P+GKG +G V A ++ +A+K + A K + LR E+++ H+ H NI+ + Sbjct: 14 RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRL 73 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 R VY+ E +++ ++ E+ ++ ++ L Y HS Sbjct: 74 YGYFHDATR-----VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKR 128 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 V+HRD+KP NLLL + +LKI DFG + V + S T T Y PE++ + Sbjct: 129 VIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEG-RMHDEK 186 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+WS+G + E + KP F + + + + T + Sbjct: 187 VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPD------------------- 227 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 V A DLI ++L +P +R + + L HP++ + Sbjct: 228 -----------FVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 262 >4JG6-A nrPDB Length = 355 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 80/323 (24%), Positives = 139/323 (43%), Gaps = 48/323 (14%) Query: 49 YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL 108 + N + T Y+ IG G+Y + ++ TN A+K I + + + Sbjct: 24 QQLHRNSIQFTDGYEVK-EDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE----- 77 Query: 109 REIKLL-RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHC 166 EI++L R+ H NI+ ++D+ VY+ ELM +L I + SE Sbjct: 78 -EIEILLRYGQHPNIITLKDVYDDGKY-----VYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLL-LNANCD---LKICDFGLARVT-SESDFMT 221 L+ I + ++Y+H+ V+HRDLKPSN+L ++ + + ++ICDFG A+ +E+ + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM 191 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF-PGRDHVHQLRLLMELI 280 T + APE+L Y AA D+WS+G + ++ F G D Sbjct: 192 TPCYTANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD----------- 239 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 + + ++ + +V A DL+ KML DP +R+T Sbjct: 240 -------------TPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAA 286 Query: 341 DALAHPYLNSLHDISDEPECTIP 363 L HP++ P+ + Sbjct: 287 LVLRHPWIVHW---DQLPQYQLN 306 >4J52-A nrPDB Length = 293 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 136/308 (44%), Gaps = 41/308 (13%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAIRD 127 +GKG + +++T E A K + + K + + EI + R + H+++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 128 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 V++ EL L ++ + +AL+E +Y+L QI+ G +Y+H V+ Sbjct: 82 FFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 136 Query: 187 HRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLK NL LN + ++KI DFGLA +V + + T Y APE+L + ++ + Sbjct: 137 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 195 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS+GCI L+ KP F E L E R + Sbjct: 196 DVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIKKNEYSI 233 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC--TIP 363 P+ ++P+A LI+KML DP R T+ + L + S + + P TIP Sbjct: 234 PK--------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIP 285 Query: 364 FNFDFENH 371 F Sbjct: 286 PRFSIAPS 293 >3UDB-A nrPDB Length = 317 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 118/293 (40%), Gaps = 35/293 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IG G +G+ + + NE VA+K I KID + REI R + Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG--EKID-ENVKREIINHRSLR 73 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV +++I P A I E +L + I + SE+ ++F Q++ G+ Sbjct: 74 HPNIVRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 178 KYIHSANVLHRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 Y H+ V HRDLK N LL+ + LKI DFG ++ + V T Y APE+L Sbjct: 129 SYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVL 188 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 L DVWS G ++ F EE + + Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPFE------------------DPEEPKNFRKTI 230 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 R + P + + P LI ++ DP +RI++ + H + Sbjct: 231 HRILNVQYAIP------DYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >1NY3-A nrPDB Length = 400 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 88/345 (25%), Positives = 141/345 (40%), Gaps = 41/345 (11%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RH 116 + YK +G G G V N T E A+K + D + RE++L R Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRA 111 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQI 173 +IV I D+ L + I E +D +L I R +QA +E + I Sbjct: 112 SQCPHIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +T T +Y Sbjct: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE+L Y + D+WS+G I L+ P F H L + + + EF Sbjct: 231 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEF 286 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N ++ V LI +L +P +R+T+ + + HP++ Sbjct: 287 PNP-------------------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQQ 395 + P T + + E +KE + +Y+Q Sbjct: 328 STKVPQTPLHT---SRVLKEDKERWEDVKEEMTSALATMRVDYEQ 369 >3KA0-A nrPDB Length = 320 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 138/335 (41%), Gaps = 46/335 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RH 116 + YK +G G G V N T E A+K + D + RE++L R Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRA 65 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQI 173 +IV I D+ L + I E +D +L I R +QA +E + I Sbjct: 66 SQCPHIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 124 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +TE T +Y Sbjct: 125 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYV 184 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE+L Y + D+WS+G I L+ P F H L + + + EF Sbjct: 185 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEF 240 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N ++ V LI +L +P +R+T+ + + HP++ Sbjct: 241 PNP-------------------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 281 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKELIYRE 385 + P + L E++ + +E Sbjct: 282 STKVPQTPL--------HTSRVLKEDKERWEDVKE 308 >4JXF-A nrPDB Length = 266 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 130/285 (45%), Gaps = 40/285 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAIRD 127 +GKG++ V A + T VAIK I K +R E+K+ + H +I+ + + Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 128 IIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANV 185 N VY+ E+ + ++++ +++ + SE ++F++QI+ G+ Y+HS + Sbjct: 75 YFEDS-----NYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGI 129 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 LHRDL SNLLL N ++KI DFGLA + T Y +PE + S + Sbjct: 130 LHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRSAHGLE 188 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 DVWS+GC+F L+ +P F + L ++ Sbjct: 189 SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--------------------------- 221 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + + + A DLI ++L +P R+++ L HP+++ Sbjct: 222 ---LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2OZA-A nrPDB Length = 356 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 88/345 (25%), Positives = 141/345 (40%), Gaps = 41/345 (11%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RH 116 + YK +G G G V N T E A+K + D + RE++L R Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRA 67 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQI 173 +IV I D+ L + I E +D +L I R +QA +E + I Sbjct: 68 SQCPHIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ + +T T +Y Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 186 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE+L Y + D+WS+G I L+ P F H L + + + EF Sbjct: 187 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEF 242 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N ++ V LI +L +P +R+T+ + + HP++ Sbjct: 243 PNP-------------------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 283 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQQ 395 + P T + + E +KE + +Y+Q Sbjct: 284 STKVPQTPLHT---SRVLKEDKERWEDVKEEMTSALATMRVDYEQ 325 >3Q53-A nrPDB Length = 306 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 135/311 (43%), Gaps = 37/311 (11%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S + ++ + KY IG+GA G V +AM+ T + VAI+++ Sbjct: 1 MSDEEILEKLRSIVSVGDPKKKYTRF-EKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQ 59 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ 159 K + + EI ++R + NIV D +++++ E + + + Sbjct: 60 PKKEL--IINEILVMRENKNPNIVNYLDSYLVG-----DELWVVMEYLAGGSLTDVVTET 112 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESD 218 + E + L+ L+++HS V+HRD+K N+LL + +K+ DFG A++T E Sbjct: 113 CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQS 172 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 + V T ++ APE++ Y +D+WS+G + +E+++ +P + + + L L+ Sbjct: 173 KRSTMVGTPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA- 230 Query: 279 LIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 GTP + E L + D + + L D +R + Sbjct: 231 TNGTPELQNPEKL--------------------------SAIFRDFLNRCLEMDVEKRGS 264 Query: 339 VLDALAHPYLN 349 + + H +L Sbjct: 265 AKELIQHQFLK 275 >3FXW-A nrPDB Length = 336 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 80/343 (23%), Positives = 140/343 (40%), Gaps = 40/343 (11%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 + VT Y+ +G G G V + T + A+K + D+ + +E+ Sbjct: 24 YAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKARQEVDHHW 76 Query: 116 HMDH-ENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLY 171 +IV I D+ + + + I E M+ +L I R +QA +E + Sbjct: 77 QASGGPHIVCILDVYEN-MHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMR 135 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRW 228 I ++++HS N+ HRD+KP NLL + + LK+ DFG A+ T+++ T T + Sbjct: 136 DIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP-CYTPY 194 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 Y APE+L Y + D+WS+G I L+ P F Sbjct: 195 YVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------------------- 234 Query: 289 EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + ++ KR IR ++ V A LI +L DP R+T+ + HP++ Sbjct: 235 QAISPGMKRRIRL---GQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 291 Query: 349 NSLHDISDEPE-CTIPFNFDFENHALSEEQMKELIYREALAFN 390 N + P D ++ +E+M + + ++ Sbjct: 292 NQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYD 334 >5D9K-A nrPDB Length = 330 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 137/337 (40%), Gaps = 55/337 (16%) Query: 26 PSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS-- 83 P+PQ + ++H + + FE+ + +G+G++G V Sbjct: 2 PNPQTEEVSIKEIAITHHVKEGHEKADPSQFEL-------LKVLGQGSFGKVFLVKKISG 54 Query: 84 -ETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYI 142 + + A+K + A D RT E +L ++H IV + + +Y+ Sbjct: 55 SDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGK-----LYL 109 Query: 143 AYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC 201 + + DL + +EE +++L ++ L ++HS +++RDLKP N+LL+ Sbjct: 110 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG 169 Query: 202 DLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR 260 +K+ DFGL++ + + + + T Y APE++ N +T + D WS G + E++ Sbjct: 170 HIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTG 228 Query: 261 KPLFPGRDHVHQLRLLMEL-IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHP 319 F G+D + ++++ +G P + P Sbjct: 229 TLPFQGKDRKETMTMILKAKLGMPQF-------------------------------LSP 257 Query: 320 LAIDLIEKMLTFDPRRRITV-----LDALAHPYLNSL 351 A L+ + +P R+ + H + +++ Sbjct: 258 EAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTI 294 >4YNZ-A nrPDB Length = 342 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 125/311 (40%), Gaps = 37/311 (11%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +GKG G+V ++ T + VAIK + ++ + REI +L+ ++H +++ + Sbjct: 16 KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLH 75 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 D+ +Y+ E + +L + L+ + + F QI+ L + HS ++ Sbjct: 76 DVYENKKY-----LYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 HRDLKP NLLL+ +++I DFG+A + + + Y PE++ Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 190 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 DVWS G I L+ F + L E KR + +P + Sbjct: 191 DVWSCGVILFALLVGALPFDDDNLRQLL-------------------EKVKRGVFHMPHF 231 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 + P L+ M+ D RR+T+ H + + EPE IP Sbjct: 232 -----------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKN-EPEPEQPIPRK 279 Query: 366 FDFENHALSEE 376 + E+ Sbjct: 280 VQIRSLPSLED 290 >6CMJ-A nrPDB Length = 321 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 139/304 (45%), Gaps = 44/304 (14%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAF---------DNKIDAKRTLREIKLLRHMD 118 IGKG+YG+V A N N A+K ++ + ++ +EI +L+ +D Sbjct: 41 EIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLD 100 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 H N+V + +++ P + +Y+ +EL++ + + + LSE+ +++ +++G++ Sbjct: 101 HPNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIE 157 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRWYRAPELLLN 237 Y+H ++HRD+KPSNLL+ + +KI DFG++ SD ++ V T + APE L Sbjct: 158 YLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSE 217 Query: 238 SSDY--TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + A+DVW++G + + F +M L + LEF ++ Sbjct: 218 TRKIFSGKALDVWAMGVTLYCFVFGQCPF-------MDERIMCLHSKIKSQALEFPDQ-- 268 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P + DLI +ML +P RI V + HP++ H Sbjct: 269 -------------------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR-HGAE 308 Query: 356 DEPE 359 P Sbjct: 309 PLPS 312 >1KOB-A nrPDB Length = 387 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 123/294 (41%), Gaps = 36/294 (12%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 Y + +G GA+G+V + T K I + +D EI ++ + H Sbjct: 52 YYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKNEISIMNQLHHPK 109 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYI 180 ++ + D + V I L +L I + +SE ++ Q GLK++ Sbjct: 110 LINLHDAFEDK----YEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHM 165 Query: 181 HSANVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 H +++H D+KP N++ +KI DFGLA + + + T + APE++ + Sbjct: 166 HEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DR 224 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 D+W++G + L+ F G D + L+ + + EF Sbjct: 225 EPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC-------DWEF-------- 269 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 D F +V P A D I+ +L +PR+R+TV DAL HP+L H Sbjct: 270 -----------DEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >6CKI-A nrPDB Length = 316 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 127/319 (39%), Gaps = 40/319 (12%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HE 120 Y+ +G+GA+ V + +N T++ A+K I + R RE+++L H Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH--IRSRVFREVEMLYQCQGHR 71 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 N+ + + Y+ +E M + I + +E + + L + Sbjct: 72 NV-----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF 126 Query: 180 IHSANVLHRDLKPSNLLLNANCD---LKICDFGLARVTS--------ESDFMTEYVVTRW 228 +H+ + HRDLKP N+L +KICDFGL + + + Sbjct: 127 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAE 186 Query: 229 YRAPELL----LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 Y APE++ +S Y D+WS+G I L+ P F GR E P+ Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEAC--PA 244 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 + + F + +Y + + + A DLI K+L D ++R++ L Sbjct: 245 CQNMLFESIQEGKY---------EFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 345 HPYLNSLHDISDEPECTIP 363 HP++ PE T+P Sbjct: 296 HPWVQGC-----APENTLP 309 >2XIK-A nrPDB Length = 294 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 125/294 (42%), Gaps = 37/294 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IGKG++G V +++ T E VAIK I + + + + + +EI +L D Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKII-DLEEAEDEIEDIQQEITVLSQCD 75 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 I + ++I E + + L E + L +IL+GL Sbjct: 76 SPYITRYFGSYLKSTK-----LWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 130 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRWYRAPELLLN 237 Y+HS +HRD+K +N+LL+ D+K+ DFG+A +++ +V T ++ APE++ Sbjct: 131 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 190 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 S+ Y D+WS+G +EL +P +H +R+L + Sbjct: 191 SA-YDFKADIWSLGITAIELAKGEPP---NSDLHPMRVLFLI------------------ 228 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 P+ S + +E L DPR R T + L H ++ Sbjct: 229 --------PKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRY 274 >4QMW-A nrPDB Length = 310 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 134/318 (42%), Gaps = 41/318 (12%) Query: 32 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 91 G E + + G N+ + E+ + IGKG++G V +++ T + VAI Sbjct: 4 GSEFMAHSPVQSGLPGMQNLKADPEEL----FTKLEKIGKGSFGEVFKGIDNRTQKVVAI 59 Query: 92 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 151 K I + + + + + +EI +L D + + ++I E + Sbjct: 60 KII-DLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTK-----LWIIMEYLGGGS 113 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 211 + L E L +IL+GL Y+HS +HRD+K +N+LL+ + ++K+ DFG+A Sbjct: 114 ALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA 173 Query: 212 RVTSESD-FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHV 270 +++ +V T ++ APE++ S+ Y + D+WS+G +EL +P + Sbjct: 174 GQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDSKADIWSLGITAIELARGEPP---HSEL 229 Query: 271 HQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 H +++L + P+ + + +E L Sbjct: 230 HPMKVLFLI--------------------------PKNNPPTLEGNYSKPLKEFVEACLN 263 Query: 331 FDPRRRITVLDALAHPYL 348 +P R T + L H ++ Sbjct: 264 KEPSFRPTAKELLKHKFI 281 >5F9E-A nrPDB Length = 353 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 78/324 (24%), Positives = 134/324 (41%), Gaps = 51/324 (15%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKRTLREIKLLRHM-DHENIVA 124 +GKG++G V A +TN+ AIK + D + T+ E ++L +H + Sbjct: 25 KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTH 84 Query: 125 IRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + +++ E + DL I+S ++ +I+ GL+++HS Sbjct: 85 MFCTFQTK-----ENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSK 139 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSDYT 242 +++RDLK N+LL+ + +KI DFG+ + D T E+ T Y APE+LL Y Sbjct: 140 GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG-QKYN 198 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 ++D WS G + E++ + F G+D + Sbjct: 199 HSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRM----------------------DN 236 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-DALAHPYLNSLH--------- 352 P YPR + A DL+ K+ +P +R+ V D HP ++ Sbjct: 237 PFYPR--------WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEI 288 Query: 353 DISDEPECTIPFNFD-FENHALSE 375 D P+ PF+ F+ L+E Sbjct: 289 DPPFRPKVKSPFDCSNFDKEFLNE 312 >3ALO-A nrPDB Length = 327 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 133/316 (42%), Gaps = 38/316 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 ++ TA+ + IG+GAYG V ++ + + +A+K+I + D K + + ++R Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-----NQALSEEHCQYFL 170 D IV + D +I ELM T + + + + EE Sbjct: 77 SSDCPYIVQFYGALFRE-----GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKIT 131 Query: 171 YQILRGLKYI-HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 ++ L ++ + ++HRD+KPSN+LL+ + ++K+CDFG++ +S T R Y Sbjct: 132 LATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY 191 Query: 230 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 APE + + Y DVWS+G EL + +P Sbjct: 192 MAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--------------------- 230 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 346 + + + + ++ PP S +F P I+ + LT D +R + L HP Sbjct: 231 KWNSVFDQLTQVVKGDPPQLSNSEEREF---SPSFINFVNLCLTKDESKRPKYKELLKHP 287 Query: 347 YLNSLHDISDEPECTI 362 ++ + + E C + Sbjct: 288 FILMYEERAVEVACYV 303 >2UV2-A nrPDB Length = 325 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 41/298 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + I +G GA+G V A N ET+ A K I + ++ + + EI +L D Sbjct: 35 PEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEEL--EDYMVEIDILASCD 92 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQ--IIRSNQALSEEHCQYFLYQILRG 176 H NIV + D N+++I E ++ + L+E Q Q L Sbjct: 93 HPNIVKLLDAFYYE-----NNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDA 147 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELL 235 L Y+H ++HRDLK N+L + D+K+ DFG+ A+ T ++ T ++ APE++ Sbjct: 148 LNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVV 207 Query: 236 L----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 + Y DVWS+G +E+ + +P ++ +R+L+++ Sbjct: 208 MCETSKDRPYDYKADVWSLGITLIEMAEIEPP---HHELNPMRVLLKI------------ 252 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + PP Q D ++K L + R T L HP++ Sbjct: 253 -------AKSEPPTLAQP-----SRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >1FOT-A nrPDB Length = 318 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 119/298 (39%), Gaps = 45/298 (15%) Query: 61 KYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLRHMDH 119 + + +G G++G V + A+K + + T E +L + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLK 178 I+ + +++ + ++ +L ++R +Q +++ ++ L+ Sbjct: 66 PFIIRMWGTFQDA-----QQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 Y+HS ++++RDLKP N+LL+ N +KI DFG A+ + + T Y APE++ ++ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVV-ST 177 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 Y +ID WS G + E++ F + + ++ Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL-------------------NA 218 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSL 351 + PP+ + DL+ +++T D +R+ D HP+ + Sbjct: 219 ELRFPPF-----------FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEV 265 >4FZF-B nrPDB Length = 283 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 65/291 (22%), Positives = 122/291 (41%), Gaps = 37/291 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + IGKG++G V +++ T + VAIK I + + + + + +EI +L D Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKII-DLEEAEDEIEDIQQEITVLSQCD 64 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 + + ++I E + + E L +IL+GL Sbjct: 65 SSYVTKYYGSYLKGSK-----LWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLD 119 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRWYRAPELLLN 237 Y+HS +HRD+K +N+LL+ D+K+ FG+A +++ +V T ++ APE++ Sbjct: 120 YLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 179 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 S+ Y + D+WS+G +EL +P +H +R+L + Sbjct: 180 SA-YDSKADIWSLGITAIELAKGEPP---NSDMHPMRVLFLI------------------ 217 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 P+ + + I+ L DP R T + L H ++ Sbjct: 218 --------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >4L42-A nrPDB Length = 346 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 73/362 (20%), Positives = 140/362 (38%), Gaps = 50/362 (13%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS---ETNESVAIKKIANAF-- 98 G + ++ ++ + + +GKG YG V T + A+K + A Sbjct: 1 GAMSETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIV 60 Query: 99 DNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS 157 N D T E +L + H IV + + +Y+ E + +L + Sbjct: 61 RNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGK-----LYLILEYLSGGELFMQLER 115 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSE 216 E+ ++L +I L ++H +++RDLKP N++LN +K+ DFGL + + Sbjct: 116 EGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHD 175 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 + T Y APE+L+ S + A+D WS+G + +++ P F G + + + Sbjct: 176 GTVTHTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 234 Query: 277 MELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 ++ LPPY + A DL++K+L + R Sbjct: 235 LKC-------------------KLNLPPY-----------LTQEARDLLKKLLKRNAASR 264 Query: 337 IT-----VLDALAHPYLNSLH-DISDEPECTIPFNFDFENHALSEEQMKELIYREALAFN 390 + + AHP+ ++ + + PF ++ Q R+ + Sbjct: 265 LGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEE-DVSQFDSKFTRQTPVDS 323 Query: 391 PE 392 P+ Sbjct: 324 PD 325 >2Z7Q-A nrPDB Length = 321 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 63/333 (18%), Positives = 133/333 (39%), Gaps = 49/333 (14%) Query: 47 IQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS---ETNESVAIKKIANAFDNKID 103 I +++ + + + +G+G++G V ++ A+K + A D Sbjct: 14 ITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRD 73 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALS 162 RT E +L ++H +V + + +Y+ + + DL + + Sbjct: 74 RVRTKMERDILADVNHPFVVKLHYAFQTEGK-----LYLILDFLRGGDLFTRLSKEVMFT 128 Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT- 221 EE +++L ++ GL ++HS +++RDLKP N+LL+ +K+ DFGL++ + + Sbjct: 129 EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAY 188 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL-I 280 + T Y APE++ N ++ + D WS G + E++ F G+D + L+++ + Sbjct: 189 SFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKL 247 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI--- 337 G P + A L+ + +P R+ Sbjct: 248 GMPQF-------------------------------LSTEAQSLLRALFKRNPANRLGSG 276 Query: 338 --TVLDALAHPYLNSLH-DISDEPECTIPFNFD 367 + H + +++ + E PF Sbjct: 277 PDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 309 >3HDN-A nrPDB Length = 373 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 126/313 (40%), Gaps = 43/313 (13%) Query: 65 PIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLL-RHMDHENI 122 + IGKG++G V A + A+K + A K + K + E +L +++ H + Sbjct: 42 FLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFL 101 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 V + + F YI +L ++ + E +++ +I L Y+HS Sbjct: 102 VGLHFSFQTADKLYFVLDYIN----GGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 157 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPELLLNSSDY 241 N+++RDLKP N+LL++ + + DFGL + E + T + T Y APE+L + Y Sbjct: 158 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL-HKQPY 216 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +D W +G + E++ P F R+ ++ Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL------------------------ 252 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL----DALAHPYLNSLH-DISD 356 P + A L+E +L D +R+ + +H + + ++ D Sbjct: 253 ------NKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLI 306 Query: 357 EPECTIPFNFDFE 369 + T PFN + Sbjct: 307 NKKITPPFNPNVS 319 >3DAK-A nrPDB Length = 290 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 119/311 (38%), Gaps = 41/311 (13%) Query: 55 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 + + IG GA +V +A + E VAIK+I N + L+EI+ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRI-NLEKCQTSMDELLKEIQAM 62 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIR--------SNQALSEEH 165 H NIV+ +++++ +L+ + II+ + L E Sbjct: 63 SQCHHPNIVSYYTSFVVK-----DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD------F 219 L ++L GL+Y+H +HRD+K N+LL + ++I DFG++ + Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 +V T + APE++ Y D+WS G +EL + + L L ++ Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQ- 236 Query: 280 IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 PS E E K+Y + I L DP +R T Sbjct: 237 NDPPSLETGVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRPTA 277 Query: 340 LDALAHPYLNS 350 + L H + Sbjct: 278 AELLRHKFFQK 288 >4I6B-A nrPDB Length = 308 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 128/317 (40%), Gaps = 41/317 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL-REIKLLRHM 117 T K +GKG + + N+ A K I ++ +K + + +EI+L R + Sbjct: 26 TGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRIL 85 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRG 176 H+++V ++YI E + I+++ + L+E +Y+L QI+ G Sbjct: 86 HHKHVVQFYHYFEDK-----ENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSG 140 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFMTEYVVTRWYRAPELL 235 LKY+H +LHRDLK N +N + +LK+ DFGLA R+ T Y +PE+L Sbjct: 141 LKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL 200 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 N + A D+W++GC+ ++ +P F + R + E T L Sbjct: 201 -NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL------- 252 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 A LI ML+ +P R ++ D + H + Sbjct: 253 -----------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPD 289 Query: 356 DEPE--CTIPFNFDFEN 370 C +F + Sbjct: 290 RLSSSCCHTVPDFHLSS 306 >5YV8-A nrPDB Length = 298 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 137/309 (44%), Gaps = 58/309 (18%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAF------------------------DNKID 103 IGKG+YG+V A N N A+K ++ + Sbjct: 20 EIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGP 79 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 163 ++ +EI +L+ +DH N+V + +++ P + +Y+ +EL++ + + + LSE Sbjct: 80 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVPTLKPLSE 136 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTE 222 + +++ +++G++Y+H ++HRD+KPSNLL+ + +KI DFG++ SD ++ Sbjct: 137 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 196 Query: 223 YVVTRWYRAPELLLNSSDY--TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 V T + APE L + A+DVW++G + + F +M L Sbjct: 197 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------MDERIMCLH 249 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 + LEF ++ P + DLI +ML +P RI V Sbjct: 250 SKIKSQALEFPDQ---------------------PDIAEDLKDLITRMLDKNPESRIVVP 288 Query: 341 DALAHPYLN 349 + HP++ Sbjct: 289 EIKLHPWVT 297 >3VN9-A nrPDB Length = 340 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 92/342 (26%), Positives = 150/342 (43%), Gaps = 47/342 (13%) Query: 22 PAAAPSPQMPGIE-NIPATLSHGGRFIQYN----IFGNIFEVTAKYKPPIMPIGKGAYGI 76 P ++P P T S R + I FEV A PIM +G+GAYG+ Sbjct: 7 KKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGV 66 Query: 77 VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-LRHMDHENIVAIRDIIPPPLRN 135 V + + + +A+K+I A N + KR L ++ + +R +D V + Sbjct: 67 VEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE--- 122 Query: 136 AFNDVYIAYELMDTDLHQI----IRSNQALSEEHCQYFLYQILRGLKYIHSA-NVLHRDL 190 DV+I ELMDT L + I Q + E+ I++ L+++HS +V+HRD+ Sbjct: 123 --GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 Query: 191 KPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL---LNSSDYTAAIDV 247 KPSN+L+NA +K+CDFG++ +S T + Y APE + LN Y+ D+ Sbjct: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 Query: 248 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 307 WS+G +EL + FP + L +++ PS P P Sbjct: 241 WSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPS------------------PQLPA 280 Query: 308 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 + +F +D + L + + R T + + HP+ Sbjct: 281 DKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFFT 315 >6O6Q-A nrPDB Length = 335 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 152/321 (47%), Gaps = 20/321 (6%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 + + Y+ + Y+ + +G+G Y V ++ E E V IK + Sbjct: 22 TKPQSYWDYDDLNIKWNPQENYEI-LRKLGRGKYSEVFLGIDLEKREKVVIKVLK----- 75 Query: 101 KIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ 159 + K+ REI +L+++ D NI+A+ D++ P + +E ++ Sbjct: 76 PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPG---LIFEHINN--IDFRSLYP 130 Query: 160 ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDL-KICDFGLARVTSESD 218 ++ ++++Y++L+ L Y HS ++HRD+KP N++++ + L ++ D+GLA Sbjct: 131 TFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGT 190 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL-MDRKPLFPGRDHVHQLRLLM 277 V +R+++ PELL++ Y ++D+WS GC+ + ++P F G+ + QL ++ Sbjct: 191 EYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIV 250 Query: 278 ELIGTPSEEEL------EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 ++G+ + ++ E + R + V +DLI+++L + Sbjct: 251 RVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRY 310 Query: 332 DPRRRITVLDALAHPYLNSLH 352 D + R+T +A+ H Y + + Sbjct: 311 DHQERLTAKEAMKHAYFDPIR 331 >3HKO-A nrPDB Length = 345 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 82/363 (22%), Positives = 142/363 (39%), Gaps = 84/363 (23%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN---AFD 99 GR Y G++ E+ KY IG+G+YG+V A+ ++T AIK + Sbjct: 9 SGRENLYFQGGSLLELQKKYHLK-GAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQI 67 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-----LHQI 154 N D +R E++L++ + H NI + ++ + + EL L+ Sbjct: 68 NPKDVERIKTEVRLMKKLHHPNIARLYEVYEDE-----QYICLVMELCHGGHLLDKLNVF 122 Query: 155 IRS--------------------------------NQALS----EEHCQYFLYQILRGLK 178 I ++L E+ + QI L Sbjct: 123 IDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALH 182 Query: 179 YIHSANVLHRDLKPSNLLLNAN--CDLKICDFGLARV---TSESDF--MTEYVVTRWYRA 231 Y+H+ + HRD+KP N L + N ++K+ DFGL++ + ++ MT T ++ A Sbjct: 183 YLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVA 242 Query: 232 PELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 PE+L + Y D WS G + L+ FPG + + ++ ++L F Sbjct: 243 PEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVL-------NKKLCF 295 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N N + + PLA DL+ +L + R + AL HP+++ Sbjct: 296 ENPN-------------------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQ 336 Query: 351 LHD 353 D Sbjct: 337 FSD 339 >6FYV-A nrPDB Length = 337 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 85/339 (25%), Positives = 146/339 (43%), Gaps = 47/339 (13%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE-TNESVAIKKIANAFDNKIDAKRTLREIK 112 +V + +G+GA+G V ++ VA+K + N + EI+ Sbjct: 7 QSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQ 63 Query: 113 LLRHMDH--ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSE--EHCQY 168 +L H++ N V R + + V I +EL+ + I+ N L +H + Sbjct: 64 VLEHLNSTDPNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQ 122 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNA-------------------NCDLKICDFG 209 YQI + + ++H + H DLKP N+L N D+K+ DFG Sbjct: 123 MAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG 182 Query: 210 LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 A T + + + V TR YRAPE++L + ++ DVWS+GCI +E +F D Sbjct: 183 SA--TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDS 239 Query: 270 VHQLRLLMELIGTPSEEELEFL---------------NENAKRYIRQLPPYPRQSITDKF 314 L ++ ++G + ++ + +A RY+R+ P + Sbjct: 240 KEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCH 298 Query: 315 PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 H DL+ +ML +DP +RIT+ +AL HP+ + L Sbjct: 299 DEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >5X8I-B nrPDB Length = 346 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 84/338 (24%), Positives = 144/338 (42%), Gaps = 45/338 (13%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAM-NSETNESVAIKKIANAFDNKIDAKRTLREIK 112 +V + + +G+GA+G V + + VA+K + N + EI+ Sbjct: 6 QSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNV---DRYCEAARSEIQ 62 Query: 113 LLRHMD--HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALS--EEHCQY 168 +L H++ N R + + I +EL+ + I+ N L +H + Sbjct: 63 VLEHLNTTDPN-STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRK 121 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNA-------------------NCDLKICDFG 209 YQI + + ++HS + H DLKP N+L N D+K+ DFG Sbjct: 122 MAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG 181 Query: 210 LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 A T + + + V TR YRAPE++L + ++ DVWS+GCI +E +FP D Sbjct: 182 SA--TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDS 238 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP--------------YPRQSITDKFP 315 L ++ ++G + ++ + + +L P + Sbjct: 239 KEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQD 298 Query: 316 TVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 H DLI+KML +DP +RIT+ +AL HP+ + L Sbjct: 299 VEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 336 >3UTO-A nrPDB Length = 573 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 118/294 (40%), Gaps = 42/294 (14%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G GA+G+V T + A K + ++ D + +EI+ + + H +V + Sbjct: 163 EELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKETVRKEIQTMSVLRHPTLVNLH 220 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQII-RSNQALSEEHCQYFLYQILRGLKYIHSAN 184 D N++ + YE M +L + + + +SE+ ++ Q+ +GL ++H N Sbjct: 221 DAFEDD-----NEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENN 275 Query: 185 VLHRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS--SD 240 +H DLKP N++ + +LK+ DFGL + T + APE+ Sbjct: 276 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGY 335 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 YT D+WSVG + L+ F G + LR + + Sbjct: 336 YT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDD--------------- 377 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 F + D I K+L DP R+T+ AL HP+L + Sbjct: 378 -----------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >4RLP-A nrPDB Length = 288 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 124/308 (40%), Gaps = 48/308 (15%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNS---ETNESVAIKKIANAF--DNKIDAKRTLREI 111 ++ + + +GKG YG V T + A+K + A N D T E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 +L + H IV + + +Y+ E + +L + E+ ++L Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGK-----LYLILEYLSGGELFMQLEREGIFMEDTACFYL 115 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWY 229 +I L ++H +++RDLKP N++LN +K+ DFGL + + + T Y Sbjct: 116 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 APE+L+ S + A+D WS+G + +++ P F G + + +++ Sbjct: 176 MAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC---------- 224 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALA 344 LPPY + A DL++K+L + R+ + A Sbjct: 225 ---------KLNLPPY-----------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQA 264 Query: 345 HPYLNSLH 352 HP+ ++ Sbjct: 265 HPFFRHIN 272 >5DBX-A nrPDB Length = 328 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 73/332 (21%), Positives = 125/332 (37%), Gaps = 41/332 (12%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 + + IG GA +V +A+ E VAIK+I N + L+EI+ + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRI-NLEKCQTSMDELLKEIQAMS 64 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIR--------SNQALSEEHC 166 H N+V +++++ +L+ + II+ N L E Sbjct: 65 QCSHPNVVTYYTSFVVK-----DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAII 119 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT----- 221 L ++L GL Y+H +HRDLK N+LL + ++I DFG++ + +T Sbjct: 120 ATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVR 179 Query: 222 -EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 ++V T + APE++ Y D+WS G +EL + + L L ++ Sbjct: 180 KDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQ-N 238 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 P+ E E K+Y + L+ L DP +R T Sbjct: 239 DPPTLETGVEDKEMMKKYGKSFRK-------------------LLSLCLQKDPSKRPTAA 279 Query: 341 DALAHPYLNSLHDISDEPECTIPFNFDFENHA 372 + L + + E + D A Sbjct: 280 ELLKCKFFQKAKNREYLIEKLLTRTPDIAQRA 311 >1VZO-A nrPDB Length = 355 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 145/355 (40%), Gaps = 45/355 (12%) Query: 32 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMN---SETNES 88 G + L+ N+ G+ +V + + +G GAYG V +T + Sbjct: 25 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 84 Query: 89 VAIKKIANA--FDNKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYE 145 A+K + A + T E ++L H+ +V + + YI Sbjct: 85 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYIN-- 142 Query: 146 LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 +L + + +E Q ++ +I+ L+++H +++RD+K N+LL++N + + Sbjct: 143 --GGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVL 200 Query: 206 CDFGLARVT--SESDFMTEYVVTRWYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKP 262 DFGL++ E++ ++ T Y AP+++ S + A+D WS+G + EL+ Sbjct: 201 TDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGAS 260 Query: 263 LFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAI 322 F + + ++R ++ PPYP++ + LA Sbjct: 261 PFTVDGEKNSQAEI------------------SRRILKSEPPYPQE--------MSALAK 294 Query: 323 DLIEKMLTFDPRRRIT-----VLDALAHPYLNSLH-DISDEPECTIPFNFDFENH 371 DLI+++L DP++R+ + H + ++ D + PF + Sbjct: 295 DLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDE 349 >3LM0-A nrPDB Length = 327 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 132/336 (39%), Gaps = 45/336 (13%) Query: 50 NIFGNIFE-VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL 108 N++ E Y +G+G + +V ++ T + A K + + L Sbjct: 17 NLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEIL 76 Query: 109 REIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQII--RSNQALSEE 164 EI +L ++ + ++ +++ + E ++ + + +SE Sbjct: 77 HEIAVLELAKSCPRVINLHEVYENT-----SEIILILEYAAGGEIFSLCLPELAEMVSEN 131 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMT 221 + QIL G+ Y+H N++H DLKP N+LL++ D+KI DFG++R + + Sbjct: 132 DVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELR 191 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 E + T Y APE+L N T A D+W++G I L+ F G D+ + ++ Sbjct: 192 EIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNV 250 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 341 SEE F +V LA D I+ +L +P +R T Sbjct: 251 DYSEET--------------------------FSSVSQLATDFIQSLLVKNPEKRPTAEI 284 Query: 342 ALAHPYLNSLH-----DISDEPECTIPFNFDFENHA 372 L+H +L + + + + Sbjct: 285 CLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSE 320 >3A8W-A nrPDB Length = 345 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 37/345 (10%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK-IDAKRTLREIKLLRH 116 + + + IG+G+Y V +T+ A+K + N D E + Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 117 -MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILR 175 +H +V + R F Y+ DL ++ + L EEH +++ +I Sbjct: 66 ASNHPFLVGLHSCFQTESRLFFVIEYVN----GGDLMFHMQRQRKLPEEHARFYSAEISL 121 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPEL 234 L Y+H +++RDLK N+LL++ +K+ D+G+ + D + + T Y APE+ Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 L DY ++D W++G + E+M + F ++ P + ++L + Sbjct: 182 LRG-EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTEDYLFQV 230 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV------LDALAHPYL 348 ++P ++ A +++ L DP+ R+ D HP+ Sbjct: 231 ILEKQIRIP-----------RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF 279 Query: 349 NSLH-DISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPE 392 ++ D+ ++ + PF + + E + P+ Sbjct: 280 RNVDWDMMEQKQVVPPFKPNISGE-FGLDNFDSQFTNEPVQLTPD 323 >1U5R-A nrPDB Length = 348 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 133/327 (40%), Gaps = 42/327 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHM 117 K + IG G++G V A + +E VAIKK++ + + + ++E++ L+ + Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRG 176 H N + R + ++ E ++ + L E + L+G Sbjct: 112 RHPNTIQYRGCYLRE-----HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQG 166 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL- 235 L Y+HS N++HRD+K N+LL+ +K+ DFG A + + + +V T ++ APE++ Sbjct: 167 LAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVIL 223 Query: 236 -LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 ++ Y +DVWS+G +EL +RKP + + L + + Sbjct: 224 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 267 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 + P ++ F + ++ L P+ R T L H ++ L + Sbjct: 268 -----NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFV--LRER 313 Query: 355 SDEPECTIPFNFDFENHALSEEQMKEL 381 + L Q +++ Sbjct: 314 PPTVIMDLIQRTKDAVRELDNLQYRKM 340 >1KOA-A nrPDB Length = 491 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 118/294 (40%), Gaps = 42/294 (14%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G GA+G+V T + A K + ++ D + +EI+ + + H +V + Sbjct: 57 EELGTGAFGVVHRVTERATGNNFAAKFVMTPHES--DKETVRKEIQTMSVLRHPTLVNLH 114 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQII-RSNQALSEEHCQYFLYQILRGLKYIHSAN 184 D N++ + YE M +L + + + +SE+ ++ Q+ +GL ++H N Sbjct: 115 DAFEDD-----NEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENN 169 Query: 185 VLHRDLKPSNLLLNA--NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS--SD 240 +H DLKP N++ + +LK+ DFGL + T + APE+ Sbjct: 170 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGY 229 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 YT D+WSVG + L+ F G + LR + + Sbjct: 230 YT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDD--------------- 271 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 F + D I K+L DP R+T+ AL HP+L + Sbjct: 272 -----------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >5D7A-A nrPDB Length = 308 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 127/317 (40%), Gaps = 44/317 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 124 + +G G YG V + +T + AIK + D + + +EI +L+ H NI Sbjct: 22 VELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRNIAT 78 Query: 125 IRDIIPPPLRNAFND-VYIAYELMD-TDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYI 180 +D +++ E + +I++ + L EE Y +ILRGL ++ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLNSS 239 H V+HRD+K N+LL N ++K+ DFG++ + ++ T ++ APE++ Sbjct: 139 HQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 198 Query: 240 D----YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + Y D+WS+G +E+ + P +H +R L + P+ Sbjct: 199 NPDATYDFKSDLWSLGITAIEMAEGAPP---LCDMHPMRALFLIPRNPA----------- 244 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 P + + KF IE L + +R + HP++ D Sbjct: 245 -------PRLKSKKWSKKF-------QSFIESCLVKNHSQRPATEQLMKHPFI---RDQP 287 Query: 356 DEPECTIPFNFDFENHA 372 +E + I + Sbjct: 288 NERQVRIQLKDHIDRTK 304 >2GCD-A nrPDB Length = 309 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 133/327 (40%), Gaps = 42/327 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHM 117 K + IG G++G V A + +E VAIKK++ + + + ++E++ L+ + Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRG 176 H N + R + ++ E ++ + L E + L+G Sbjct: 73 RHPNTIQYRGCYLRE-----HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQG 127 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL- 235 L Y+HS N++HRD+K N+LL+ +K+ DFG A + + + +V T ++ APE++ Sbjct: 128 LAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVIL 184 Query: 236 -LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 ++ Y +DVWS+G +EL +RKP + + L + + Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 228 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 + P ++ F + ++ L P+ R T L H ++ L + Sbjct: 229 -----NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFV--LRER 274 Query: 355 SDEPECTIPFNFDFENHALSEEQMKEL 381 + L Q +++ Sbjct: 275 PPTVIMDLIQRTKDAVRELDNLQYRKM 301 >3ORZ-A nrPDB Length = 316 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 123/295 (41%), Gaps = 45/295 (15%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAI 125 +G+G++ V A T+ AIK + K + RE ++ +DH V + Sbjct: 43 KILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 + F Y + +L + IR + E +++ +I+ L+Y+H + Sbjct: 103 YFCFQDDEKLYFGLSYA----KNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM---TEYVVTRWYRAPELLLNSSDYT 242 +HRDLKP N+LLN + ++I DFG A+V S +V T Y +PELL S Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSAC- 217 Query: 243 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 302 + D+W++GCI +L+ P F + + +++L E+ Sbjct: 218 KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF-------------- 263 Query: 303 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD------ALAHPYLNSL 351 P A DL+EK+L D +R+ + AHP+ S+ Sbjct: 264 ----------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >3TXO-A nrPDB Length = 353 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 62/368 (16%) Query: 37 PATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN 96 P S G I N + I +GKG++G V A ET + A+K + Sbjct: 2 PKESSKEGNGIGVNSSNR---LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKK 58 Query: 97 AF-DNKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQ 153 D + T+ E ++L +H + + P R ++ E + DL Sbjct: 59 DVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDR-----LFFVMEFVNGGDLMF 113 Query: 154 IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 I+ ++ E +++ +I+ L ++H +++RDLK N+LL+ K+ DFG+ + Sbjct: 114 HIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE 173 Query: 214 -TSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 + T Y APE+L Y A+D W++G + E++ F + Sbjct: 174 GICNGVTTATFCGTPDYIAPEILQEM-LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDL 232 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 ++ +H A +++ +T + Sbjct: 233 FEAIL------------------------------NDEVVYPTWLHEDATGILKSFMTKN 262 Query: 333 PRRRI-TVLD-----ALAHPYLNSLHDIS-DEPECTIPFNFDFENHALSEEQMKELIYRE 385 P R+ ++ L HP+ + + + PF ++ + Sbjct: 263 PTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSR------------ED 310 Query: 386 ALAFNPEY 393 F+P++ Sbjct: 311 VSNFDPDF 318 >6HXF-B nrPDB Length = 302 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 122/293 (41%), Gaps = 41/293 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G GA+G V A N ET A K I + ++ + + EI++L DH IV + Sbjct: 24 VGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL--EDYIVEIEILATCDHPYIVKL 81 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQ--IIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 ++I E ++ ++ L+E Q Q+L L ++HS Sbjct: 82 LGAYYHD-----GKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK 136 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGL-ARVTSESDFMTEYVVTRWYRAPELL----LNS 238 ++HRDLK N+L+ D+++ DFG+ A+ ++ T ++ APE++ + Sbjct: 137 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 + Y D+WS+G +E+ +P ++ +R+L+++ + L Sbjct: 197 TPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKIAKSDPPTLL---------- 243 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 D ++ L +P R + L HP+++S+ Sbjct: 244 --------------TPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 >6QAU-A nrPDB Length = 280 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 133/309 (43%), Gaps = 45/309 (14%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS-ETNESVAIKKIANAFDNKIDAKRTLREI 111 G++ V +G GA+ +V + +T+ VAIK I +K +EI Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEI 61 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFL 170 K+L+ + HENIVA+ D+ P N V++ E DL +++ LSE+ + FL Sbjct: 62 KILKELQHENIVALYDVQELP-----NSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFL 116 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLN---------ANCDLKICDFGLARVTSESDFMT 221 +QI ++ +HS ++HRDLKP N+LL+ + +KI DFG AR + Sbjct: 117 HQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAA 176 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 + + Y APE+++ S Y A D+WS+G + + + KP F Sbjct: 177 DLCGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQAN-------------- 221 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 341 S ++L E + + +P + + + + + R+ Sbjct: 222 --SPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLL-----------QRNQKDRMDFEA 268 Query: 342 ALAHPYLNS 350 +HP+L Sbjct: 269 FFSHPFLEQ 277 >4WNO-A nrPDB Length = 287 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 127/306 (41%), Gaps = 50/306 (16%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-SVAIKKIANAFDNKIDAKRTLREIKLL 114 FE + K IG GA+ +V + ++ VA+K I K +EIK+L Sbjct: 18 FEFSRKDL-----IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL-LGKEIKIL 71 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQI 173 + + HENIVA+ D + N VY+ E DL + + + LSE+ + FL QI Sbjct: 72 KELKHENIVALYDF-----QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQI 126 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLN---------ANCDLKICDFGLARVTSESDFMTEYV 224 ++ +HS ++HRDLKP N+LL+ + +KI DFG AR + Sbjct: 127 AGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC 186 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 + Y APE+++ S Y D+WS+G I + + K F S Sbjct: 187 GSPMYMAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQAS----------------S 229 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 ++L E K + +P + + + + R+ + Sbjct: 230 PQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQR-----------NHKDRMDFDEFFH 278 Query: 345 HPYLNS 350 HP+L++ Sbjct: 279 HPFLDA 284 >4CSV-A nrPDB Length = 275 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 112/298 (37%), Gaps = 46/298 (15%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +E+ +G G +G V N VA+K + + + + L+E ++ Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQI 60 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFL 170 ++ + H N+V + + +YI E M L +R ++ + Sbjct: 61 MKKLKHPNLVQLYGVCTKEP-----PIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA 115 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 Q+ G+ Y+ S N +HRDL N L+ N +K+ DFGLAR+ +E ++ T ++ Sbjct: 116 AQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEY-TARAGAKFPI 174 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE + + + ++ DVW+ G + E+ + +PG + + P + Sbjct: 175 KWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 +L+ + P R T + L Sbjct: 234 -----------------------------GCPEEIYELMLQCWNKSPEERPTFAETLH 262 >4RA4-A nrPDB Length = 355 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 70/352 (19%), Positives = 130/352 (36%), Gaps = 48/352 (13%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKRTLREI 111 N+ V +M +GKG++G V A T E AIK + D + T+ E Sbjct: 12 NNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 71 Query: 112 KLLRHMDHE-NIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYF 169 ++L +D + + R +Y E + DL I+ E ++ Sbjct: 72 RVLALLDKPPFLTQLHSCFQTVDR-----LYFVMEYVNGGDLMYHIQQVGKFKEPQAVFY 126 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRW 228 +I GL ++H +++RDLK N++L++ +KI DFG+ + + + T Sbjct: 127 AAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPD 186 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 Y APE++ Y ++D W+ G + E++ +P F G D + +ME + + Sbjct: 187 YIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPK--- 242 Query: 289 EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV-----LDAL 343 ++ A+ + + ++T P +R+ D Sbjct: 243 ---------------------------SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVR 275 Query: 344 AHPYLNSLH-DISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 H + + + + E PF E + R P Q Sbjct: 276 EHAFFRRIDWEKLENREIQPPFKPKVSGK--GAENFDKFFTRGQPVLTPPDQ 325 >5X3F-B nrPDB Length = 393 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 62/328 (18%), Positives = 125/328 (38%), Gaps = 50/328 (15%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI-DAKRTLREIKLLRHMDHENIVA 124 I +G G++G V + E+ A+K + K+ + TL E ++L+ ++ +V Sbjct: 89 IKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 148 Query: 125 IRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + +++Y+ E + ++ +R SE H +++ QI+ +Y+HS Sbjct: 149 LEFSFKDN-----SNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 203 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 ++++RDLKP NLL++ +++ DFG A+ T Y APE++L+ Y Sbjct: 204 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKG-YNK 260 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 A+D W++G + E+ P F + ++ Sbjct: 261 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---------------- 304 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNS-----LHD 353 DL+ +L D +R V D H + + ++ Sbjct: 305 --------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 350 Query: 354 ISDEPECTIPFNFDFENHALSEEQMKEL 381 E F + + + +E+ Sbjct: 351 RKVEAPFIPKFKGPGDTSNFDDYEEEEI 378 >4CRL-A nrPDB Length = 406 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 105/337 (31%), Positives = 164/337 (48%), Gaps = 49/337 (14%) Query: 68 PIGKGAYGIVCSAMNSETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G+G YG V A + + A+K+I + + REI LLR + H N++++ Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA---------LSEEHCQYFLYQILRG 176 + + L +A V++ ++ + DL II+ ++A L + LYQIL G Sbjct: 85 QKVF---LSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDG 141 Query: 177 LKYIHSANVLHRDLKPSNLLLN----ANCDLKICDFGLARV----TSESDFMTEYVVTRW 228 + Y+H+ VLHRDLKP+N+L+ +KI D G AR+ + VVT W Sbjct: 142 IHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW 201 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD---------HVHQLRLLMEL 279 YRAPELLL + YT AID+W++GCIF EL+ +P+F R H QL + + Sbjct: 202 YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNV 261 Query: 280 IGTPSEEELEFLNENA------KRYIRQLPPYPRQSITDKFPTVHPL--AIDLIEKMLTF 331 +G P++++ E + + K + R + V P A L++K+LT Sbjct: 262 MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTM 321 Query: 332 DPRRRITVLDALAHPYLNSLHDISDEPE----CTIPF 364 DP +RIT A+ PY L D + C IP+ Sbjct: 322 DPIKRITSEQAMQDPYF--LEDPLPTSDVFAGCQIPY 356 >4B8L-A nrPDB Length = 286 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 119/286 (41%), Gaps = 39/286 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 P+GKG +G V A + +A+K + + K + LR EI++ H+ H NI+ + Sbjct: 21 RPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 80 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + R +Y+ E +L++ ++ + E+ F+ ++ L Y H Sbjct: 81 YNYFHDRKR-----IYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERK 135 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 V+HRD+KP NLL+ +LKI DFG + V + S T Y PE++ + Sbjct: 136 VIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMIEG-KTHDEK 193 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+W G + E + P F H R ++ + Sbjct: 194 VDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFP-------------------- 233 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 P + + DLI K+L + P +R+ + + HP++ + Sbjct: 234 ----------PFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKA 269 >2PVN-A nrPDB Length = 352 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 83/322 (25%), Positives = 148/322 (45%), Gaps = 23/322 (7%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 + Y + Y+ + +G+G Y V +N NE K I Sbjct: 34 RPKEYWDYEALTVQWGEQDDYEV-VRKVGRGKYSEVFEGINVNNNE----KCIIKILKPV 88 Query: 102 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL 161 K L NIV + DI+ + + +E ++ +++ L Sbjct: 89 KKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVL--YPTL 143 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFM 220 ++ +Y++Y++L+ L Y HS ++HRD+KP N++++ L++ D+GLA Sbjct: 144 TDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEY 203 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMEL 279 V +R+++ PELL++ DY ++D+WS+GC+F ++ RK P F G D+ QL + ++ Sbjct: 204 NVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKV 263 Query: 280 IGTPSE---------EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 +GT E L R+ R P+ + D V P AID ++K+L Sbjct: 264 LGTDGLNAYLNKYRIELDPQLEALVGRHSR--KPWLKFMNADNQHLVSPEAIDFLDKLLR 321 Query: 331 FDPRRRITVLDALAHPYLNSLH 352 +D + R+T L+A+ HPY + Sbjct: 322 YDHQERLTALEAMTHPYFQQVR 343 >4WB7-A nrPDB Length = 405 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 66/362 (18%), Positives = 130/362 (35%), Gaps = 50/362 (13%) Query: 32 GIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI 91 G E F++ I +G G++G V + ET A+ Sbjct: 67 GEEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAM 126 Query: 92 KKIANAFDNKI-DAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DT 149 K + K+ + TL E ++L+ ++ +V + +++Y+ E + Sbjct: 127 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDN-----SNLYMVMEYVPGG 181 Query: 150 DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 ++ +R SE H +++ QI+ +Y+HS ++++RDLKP NLL++ +++ DFG Sbjct: 182 EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG 241 Query: 210 LARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDH 269 A+ T Y APE++L+ Y A+D W++G + E+ P F Sbjct: 242 FAKRVK--GRTWTLCGTPEYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQP 298 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 + ++ DL+ +L Sbjct: 299 IQIYEKIVSGKVRFPSHF------------------------------SSDLKDLLRNLL 328 Query: 330 TFDPRRRI-----TVLDALAHPYLNS-----LHDISDEPECTIPFNFDFENHALSEEQMK 379 D +R V D H + + ++ E F + + + + Sbjct: 329 QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEE 388 Query: 380 EL 381 E+ Sbjct: 389 EI 390 >4MD7-E nrPDB Length = 391 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 151/301 (50%), Gaps = 24/301 (7%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 + +G+G Y V A+N NE + + K+ REIK+L ++ Sbjct: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRG 90 Query: 120 -ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 NI+ + DI+ P+ + +E ++ + Q L++ ++++Y+IL+ L Sbjct: 91 GPNIITLADIVKDPVSRTPA---LVFEHVNNT--DFKQLYQTLTDYDIRFYMYEILKALD 145 Query: 179 YIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN 237 Y HS ++HRD+KP N++++ + L++ D+GLA V +R+++ PELL++ Sbjct: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 205 Query: 238 SSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEEL-------- 288 Y ++D+WS+GC+ ++ RK P F G D+ QL + +++GT + Sbjct: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Query: 289 -EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 347 N+ R+ R+ + R ++ V P A+D ++K+L +D + R+T +A+ HPY Sbjct: 266 DPRFNDILGRHSRKR--WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 Query: 348 L 348 Sbjct: 324 F 324 >3NYO-A nrPDB Length = 576 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 136/352 (38%), Gaps = 46/352 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRH 116 VT +GKG +G VC+ T + A KK+ K + L E ++L Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ--ALSEEHCQYFLYQI 173 ++ +V++ + + + LM DL I E ++ +I Sbjct: 241 VNSRFVVSLAYAYETK-----DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPE 233 GL+ +H +++RDLKP N+LL+ + ++I D GLA E + V T Y APE Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 ++ N YT + D W++GC+ E++ + F + + + E Sbjct: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPFQ-------------------QRKKKIKRE 395 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYL 348 +R ++++P + P A L ++L DP R+ + + HP Sbjct: 396 EVERLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 Query: 349 NSLH-DISDEPECTIPFNFD----FENHALSEEQMKELIYREALAFNPEYQQ 395 L+ PF D + L EQ + E + ++ Q Sbjct: 449 KKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQ 500 >5N23-A nrPDB Length = 352 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 67/371 (18%), Positives = 129/371 (34%), Gaps = 49/371 (13%) Query: 23 AAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMN 82 AAA F++ I +G G++G V + Sbjct: 4 AAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKH 63 Query: 83 SETNESVAIKKIANAFDNKI-DAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVY 141 ET A+K + K+ + TL E ++ + ++ +V + +++Y Sbjct: 64 KETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDN-----SNLY 118 Query: 142 IAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 + E ++ +R SE H +++ QI+ +Y+HS ++++RDLKP NLL++ Sbjct: 119 MVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 Query: 201 CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR 260 +K+ DFG A+ T Y APE++L+ Y A+D W++G + E+ Sbjct: 179 GYIKVADFGFAKRVK-GRTPWTLCGTPEYLAPEIILSKG-YNKAVDWWALGVLIYEMAAG 236 Query: 261 KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPL 320 P F + ++ Sbjct: 237 YPPFFADQPIQIYEKIVSGKVRFPSHF------------------------------SSD 266 Query: 321 AIDLIEKMLTFDPRRRI-----TVLDALAHPYLNS-----LHDISDEPECTIPFNFDFEN 370 DL+ +L D +R V D H + + ++ E F + Sbjct: 267 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 326 Query: 371 HALSEEQMKEL 381 + + +E+ Sbjct: 327 SNFDDYEEEEI 337 >4APC-A nrPDB Length = 350 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 119/293 (40%), Gaps = 40/293 (13%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 F+ KY + IG+G++G ++E IK+I + + + + + RE+ +L Sbjct: 20 FQSMEKY-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLA 78 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA--LSEEHCQYFLYQ 172 +M H NIV R+ +YI + DL + I + + E+ + Q Sbjct: 79 NMKHPNIVQYRESFEENGS-----LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQ 133 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV-VTRWYRA 231 I LK++H +LHRD+K N+ L + +++ DFG+ARV + + + T +Y + Sbjct: 134 ICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLS 193 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE+ N Y D+W++GC+ EL K F + + ++ Sbjct: 194 PEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII-------------- 238 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 PP L+ ++ +PR R +V L Sbjct: 239 -------SGSFPPVSLHY--------SYDLRSLVSQLFKRNPRDRPSVNSILE 276 >6BDL-A nrPDB Length = 347 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 120/299 (40%), Gaps = 42/299 (14%) Query: 62 YKPPIMPIGKGAYGIVCSAMNS-ETNESVAIKKIANAFD-NKIDAKRTLREIKLLRHMDH 119 I +G G +G V E +++ A+K + + + E ++++ Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 + IV + +Y+ E + +L I+R + + +++ ++ Sbjct: 95 DFIVRLYRTFKDSKY-----LYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 Y+HS +++RDLKP NL+L+ K+ DFG A+ + T Y APE++LN Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 209 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 + + D WS+G + EL+ P F G D + +++ I + +EF + AK Sbjct: 210 G-HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI-----DMIEFPKKIAKN- 262 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSLH 352 A +LI+K+ +P R+ V D H + + Sbjct: 263 ----------------------AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFN 299 >5DYK-A nrPDB Length = 853 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 122/292 (41%), Gaps = 40/292 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 IG+G +G V + T A+K ++ ++ + ++ E ++ DH I+ + Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 F + +L+ IR LS+ Q++L I+ ++Y+H N+ Sbjct: 605 VRTFKDSKYFYFLTELVT----GGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNI 660 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAI 245 ++RDLKP N+LL+ +K+ DFG A+ + V T Y APE++L Y + Sbjct: 661 VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAY--TLVGTPHYMAPEVILGKG-YGCTV 717 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 D+W++G E + F G D QL + +++ P Y Sbjct: 718 DIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILT----------------GQLTFPDY 760 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV-----LDALAHPYLNSLH 352 + + I+L++++L P+ RI D HP+ ++ + Sbjct: 761 VTDTDS----------INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFN 802 >3FME-A nrPDB Length = 290 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 137/303 (45%), Gaps = 42/303 (13%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-L 114 EV A PIM +G+GAYG+V + + + +A+K+I A N + KR L ++ + + Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISM 60 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQI----IRSNQALSEEHCQYFL 170 R +D V + DV+I ELMDT L + I Q + E+ Sbjct: 61 RTVDCPFTVTFYGALFRE-----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 171 YQILRGLKYIHSA-NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 I++ L+++HS +V+HRD+KPSN+L+NA +K+CDFG++ + + Y Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPY 175 Query: 230 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 APE + LN Y+ D+WS+G +EL + FP + L +++ PS Sbjct: 176 MAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPS-- 231 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 346 P P + +F +D + L + + R T + + HP Sbjct: 232 ----------------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHP 268 Query: 347 YLN 349 + Sbjct: 269 FFT 271 >6EII-A nrPDB Length = 352 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 156/319 (48%), Gaps = 25/319 (7%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 + Y + Y+ + +G+G Y V A+N NE + Sbjct: 42 RPSEYWDYESHVVEWGNQDDYQL-VRKLGRGKYSEVFEAINITNNEK-----VVVKILKP 95 Query: 102 IDAKRTLREIKLLRHMDH-ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 + K+ REIK+L ++ NI+ + DI+ P+ + +E ++ + Q Sbjct: 96 VKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA---LVFEHVNNT--DFKQLYQT 150 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDF 219 L++ ++++Y+IL+ L Y HS ++HRD+KP N++++ + L++ D+GLA Sbjct: 151 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE 210 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLME 278 V +R+++ PELL++ Y ++D+WS+GC+ ++ RK P F G D+ QL + + Sbjct: 211 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 270 Query: 279 LIGTPSEEEL---------EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 ++GT + N+ R+ R+ + R ++ V P A+D ++K+L Sbjct: 271 VLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR--WERFVHSENQHLVSPEALDFLDKLL 328 Query: 330 TFDPRRRITVLDALAHPYL 348 +D + R+T +A+ HPY Sbjct: 329 RYDHQSRLTAREAMEHPYF 347 >3RAW-A nrPDB Length = 381 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 139/337 (41%), Gaps = 46/337 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-SVAIKKIANAFDNKIDAKRTLREIKLLR 115 + +Y+ + +G+G +G V ++ + VA+K I N + A+ + +K ++ Sbjct: 48 WLQERYEI-VGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIK 106 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQI 173 D EN ++ N + IA+EL+ + + ++ N Q H ++ YQ+ Sbjct: 107 EKDKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQL 164 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLN-------------------ANCDLKICDFGLARVT 214 L+++H + H DLKP N+L N +++ DFG A Sbjct: 165 CHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF- 223 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 + + T V TR YR PE++L + DVWS+GCI E LF ++ L Sbjct: 224 -DHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV 281 Query: 275 LLMELIGTPSEEE----------------LEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 ++ +++G + + + + P + D V Sbjct: 282 MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV- 340 Query: 319 PLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 DL+ +ML FDP +RIT+ +AL HP+ L Sbjct: 341 -QLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >6CQF-A nrPDB Length = 297 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 123/291 (42%), Gaps = 36/291 (12%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + + +G G YG V A + + + VA+K + + D +EI +L+ Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQKEILILKTCR 71 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIVA ++I E L I + +LSE Y ++L+GL Sbjct: 72 HANIVAYHGSY-----LWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGL 126 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVTRWYRAPEL-- 234 Y+HS +HRD+K +N+L+N ++++ DFG++ + ++ T ++ APE+ Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y D+WS+G +EL + +P VH LR+L + T S + L E Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLF---DVHPLRVLFLM--TKSGYQPPRLKEK 241 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 K + I+ LT P++R + L+H Sbjct: 242 GKW--------------------SAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2WO6-A nrPDB Length = 382 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 90/345 (26%), Positives = 155/345 (44%), Gaps = 50/345 (14%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 I N + +Y+ IGKG++G V A + E VAIK I N K + E Sbjct: 45 IVKNGEKWMDRYEID-SLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK---KAFLNQAQIE 100 Query: 111 IKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQ 167 ++LL M+ H+ + + N + + +E++ +L+ ++R+ + +S + Sbjct: 101 VRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTR 160 Query: 168 YFLYQILRGLKYIH--SANVLHRDLKPSNLLLN--ANCDLKICDFGLARVTSESDFMTEY 223 F Q+ L ++ +++H DLKP N+LL +KI DFG + + + +Y Sbjct: 161 KFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY--QY 218 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 + +R+YR+PE+LL Y AID+WS+GCI +E+ +PLF G + V Q+ ++E++G P Sbjct: 219 IQSRFYRSPEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP 277 Query: 284 SEEELEFLNENAKRYIRQLPP--YPRQSITDKFPTVHP---------------------- 319 L+ A+++ +LP + + D P Sbjct: 278 PAHILD-QAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRA 336 Query: 320 -----------LAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 DLI +ML +DP+ RI AL H + D Sbjct: 337 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >5FET-A nrPDB Length = 847 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 120/289 (41%), Gaps = 42/289 (14%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 IG+G +G V + T A+K ++ ++ + ++ E ++ DH I+ + Sbjct: 539 RIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRL 598 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 N Y EL+ +L+ IR LS+ Q++L I+ ++Y+H N Sbjct: 599 VRTFKDS-----NCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERN 653 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 +++RDLKP N+LL+ +K+ DFG A+ + V T Y APE++L Y Sbjct: 654 IVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAY--TLVGTPHYMAPEVILGKG-YGCT 710 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+W++G E + F G D QL + +++ P Sbjct: 711 VDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDILT----------------GQLTFPD 753 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV-----LDALAHPYL 348 Y +I+L++++L P+ RI D H + Sbjct: 754 Y----------VSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >4FR4-A nrPDB Length = 384 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 134/306 (43%), Gaps = 35/306 (11%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLR 109 +F +V + + IGKG++G VC ++T + A+K + + + + + Sbjct: 5 VFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFK 64 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYF 169 E+++++ ++H +V + ++ + + L+ DL ++ N EE + F Sbjct: 65 ELQIMQGLEHPFLVNLWYSF----QDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLF 120 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 + +++ L Y+ + ++HRD+KP N+LL+ + + I DF +A + +T T+ Y Sbjct: 121 ICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPY 180 Query: 230 RAPELLLNSS--DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 APE+ + Y+ A+D WS+G EL+ + + R T S+E Sbjct: 181 MAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSS------------TSSKEI 228 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-VLDALAHP 346 + Y + L++K+L +P +R + + D P Sbjct: 229 VHTFETTVVTYP---------------SAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFP 273 Query: 347 YLNSLH 352 Y+N ++ Sbjct: 274 YMNDIN 279 >2BRG-A nrPDB Length = 297 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 124/289 (42%), Gaps = 37/289 (12%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + +G+GAYG V A+N T E+VA+K + + + +EI + + ++HEN+V Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIV-DMKRAVDCPENIKKEICINKMLNHENVVKF 70 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 R N Y+ E +L I + + E Q F +Q++ G+ Y+H Sbjct: 71 YG-----HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIG 125 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 + HRD+KP NLLL+ +LKI DFGLA R + + + T Y APELL + Sbjct: 126 ITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFH 185 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 +DVWS G + ++ + + Q + K Sbjct: 186 AEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ------------------EYSDWKEKKTY 227 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L P+ + PLA L+ K+L +P RIT+ D + N Sbjct: 228 LNPWKKIDSA-------PLA--LLHKILVENPSARITIPDIKKDRWYNK 267 >5XVU-A nrPDB Length = 332 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 155/324 (47%), Gaps = 21/324 (6%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 + Y+ + +Y+ IG+G Y V + ++E N A Sbjct: 13 KPKEYYDYDNLELQWNKPNRYEIM-KKIGRGKYSEVFNGYDTECNRPCA-----IKVLKP 66 Query: 102 IDAKRTLREIKLLRHMDH-ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA 160 + K+ REIK+L++++ NI+ + DI+ P+ + + +E ++ + + Sbjct: 67 VKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPS---LIFEYINNIDFKTL--YPK 121 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDF 219 +++ +Y++YQIL+ L Y HS ++HRD+KP N++++ N +++ +GLA Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQE 181 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLME 278 V +R+Y+ PELL++ Y ++D+WS+GC+ ++ +K P F G D+ QL + + Sbjct: 182 YNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAK 241 Query: 279 LIGTPSEEEL-EFLNENAKRYI------RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 ++GT + N K + + P+ IDLI+KML + Sbjct: 242 VLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIY 301 Query: 332 DPRRRITVLDALAHPYLNSLHDIS 355 D +RI +A+ HPY + + S Sbjct: 302 DHAKRIAPKEAMEHPYFREVREES 325 >4C0T-A nrPDB Length = 974 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 137/330 (41%), Gaps = 51/330 (15%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHE-NIVA 124 +G+G+Y V A + T + A+K + K + + E L + + +++ Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVIS 331 Query: 125 IRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + +Y + + +L +I+ L+EE ++F QIL +KY+H Sbjct: 332 LYFTFQDKDS-----LYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDN 386 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVT----SESDFM------TEYVVTRWYRAPE 233 V+HRDLKP N+LL+ ++I DFG AR+ ES+ +V T Y +PE Sbjct: 387 GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPE 446 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 LL N DVW+ GCI +++ KP F + + + +L Sbjct: 447 LLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL-------------- 491 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL-- 351 + + + FPT+ DLI+K+L P RR T+ + H + S+ Sbjct: 492 -------------QFAFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYFFQSVDF 535 Query: 352 HDISDEPECTIPFNFDFENHALSEEQMKEL 381 D P ++ A S ++ EL Sbjct: 536 KDFDSIWLSDPPEIGPYKMTAKSMMKVPEL 565 >4AF3-A nrPDB Length = 292 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 123/297 (41%), Gaps = 39/297 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHENIVAI 125 P+GKG +G V A +++ VA+K + + K + LR EI++ H+ H NI+ + Sbjct: 29 RPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRL 88 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + R +Y+ E +L++ ++ + E+ + ++ L Y H Sbjct: 89 YNYFYDRRR-----IYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKK 143 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 V+HRD+KP NLLL +LKI DFG + V + S T Y PE++ + Sbjct: 144 VIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEK 201 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D+W +G + EL+ P F H R ++++ Sbjct: 202 VDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA------------------- 242 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 +V A DLI K+L +P R+ + AHP++ + P Sbjct: 243 -----------SVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSAL 288 >6HMD-A nrPDB Length = 365 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 80/351 (22%), Positives = 162/351 (46%), Gaps = 25/351 (7%) Query: 22 PAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAM 81 P P+ + Y + Y+ + +G+G Y V A+ Sbjct: 15 PMPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQL-VRKLGRGKYSEVFEAI 73 Query: 82 NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH-ENIVAIRDIIPPPLRNAFNDV 140 N NE ++ + K+ RE+K+L ++ NI+ + D + P+ Sbjct: 74 NITNNE-----RVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPA-- 126 Query: 141 YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 + +E ++ + Q L++ ++++Y++L+ L Y HS ++HRD+KP N++++ Sbjct: 127 -LVFEYINNT--DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ 183 Query: 201 -CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 L++ D+GLA + V +R+++ PELL++ Y ++D+WS+GC+ ++ Sbjct: 184 QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 243 Query: 260 RK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR---------QLPPYPRQS 309 R+ P F G+D+ QL + +++GT EE +L + + Sbjct: 244 RREPFFHGQDNYDQLVRIAKVLGT--EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFI 301 Query: 310 ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC 360 ++ V P A+DL++K+L +D ++R+T +A+ HPY + +P Sbjct: 302 HSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSA 352 >5LOH-A nrPDB Length = 341 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 124/315 (39%), Gaps = 45/315 (14%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANA-FDNKIDAKRTLREIKLLRHMDHENIVA 124 + PI +GA+G V + A+K + A NK + E L IV Sbjct: 41 VKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVH 98 Query: 125 IRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + + N+VY+ E + D+ ++ EE ++ ++ L Y+H Sbjct: 99 LYYSLQSA-----NNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 153 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-------FMTEYVVTRWYRAPELLL 236 ++HRDLKP N+L++ +K+ DFGL++VT D + T Y APELLL Sbjct: 154 GIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLL 213 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 + + A+D W++G E + P F + +++ Sbjct: 214 GRA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK------------------ 254 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 356 R +P + + A +E +LT D +R + + HP + + D + Sbjct: 255 ---RDIP------WPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDV-DWEN 304 Query: 357 EPECTIPFNFDFENH 371 T+PF ++ Sbjct: 305 LQHQTMPFIPQPDDE 319 >4TNB-A nrPDB Length = 590 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 78/332 (23%), Positives = 131/332 (39%), Gaps = 42/332 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRH 116 VT +GKG +G VC+ T + A K++ K + L E ++L Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 ++ + +V + ++A V D H N EE ++ +IL G Sbjct: 241 VNSQFVVNL--AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 L+ +H N ++RDLKP N+LL+ ++I D GLA E D + V T Y APE+L Sbjct: 299 LEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL- 357 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 N+ Y + D W +GC+ E+++ + F GR EE + E + Sbjct: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK-----------VKREEVDRRVLETEE 406 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHPYLNSL 351 Y + A + + +LT D ++R+ + HP+ ++ Sbjct: 407 VYSHKF---------------SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNM 451 Query: 352 H------DISDEPECTIPFNFDFENHALSEEQ 377 + + D P P + L EQ Sbjct: 452 NFKRLEAGMLDPPFVPDP-RAVYCKDVLDIEQ 482 >2WTK-C nrPDB Length = 305 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 132/322 (40%), Gaps = 48/322 (14%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI--DAKRTLREIKLLRHMDHENIVAIR 126 +G+G+YG V ++SET A+K + +I +EI+LLR + H+N++ + Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEEHCQYFLYQILRGLKYIHSAN 184 D++ + +Y+ E + +++ S + + Q++ GL+Y+HS Sbjct: 73 DVLYNEEK---QKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQG 129 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRWYRAPELLLNSSDY 241 ++H+D+KP NLLL LKI G+A D + ++ PE+ + Sbjct: 130 IVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTF 189 Query: 242 -TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 +D+WS G + F G + + L EN + Sbjct: 190 SGFKVDIWSAGVTLYNITTGLYPFEGDN-------------------IYKLFENIGKGSY 230 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPEC 360 +P ++ DL++ ML ++P +R ++ H + H ++ P Sbjct: 231 AIPGDCGPPLS-----------DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAP-V 278 Query: 361 TIPFNFDFENHALSEEQMKELI 382 IP + D ++++ + + Sbjct: 279 PIPPSPD------TKDRWRSMT 294 >2H8H-A nrPDB Length = 535 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 127/345 (36%), Gaps = 49/345 (14%) Query: 27 SPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 S G+ + T+ + + + +E+ + + +G+G +G V + T Sbjct: 233 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 292 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 VAIK + + + L+E ++++ + HE +V + ++ +YI E Sbjct: 293 R-VAIKTLKPG---TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE------PIYIVTEY 342 Query: 147 MD-TDLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDL 203 M L ++ + + L QI G+ Y+ N +HRDL+ +N+L+ N Sbjct: 343 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 402 Query: 204 KICDFGLARVTSESDFMTEYVVTRW--YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-R 260 K+ DFGLAR+ ++++ + APE L +T DVWS G + EL Sbjct: 403 KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKG 461 Query: 261 KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPL 320 + +PG + L + P P Sbjct: 462 RVPYPGMVNREVLDQVERGYRMPCP-----------------------------PECPES 492 Query: 321 AIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 DL+ + +P R T A + S EP+ N Sbjct: 493 LHDLMCQCWRKEPEERPTFEYLQA---FLEDYFTSTEPQYQPGEN 534 >6F3F-A nrPDB Length = 455 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 128/345 (37%), Gaps = 49/345 (14%) Query: 27 SPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 S G+ + T+ + + + +E+ + + +G+G +G V + T Sbjct: 153 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 212 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 VAIK + + + L+E ++++ + HE +V + ++ +YI E Sbjct: 213 R-VAIKTLKPG---TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE------PIYIVTEY 262 Query: 147 MD-TDLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDL 203 M+ L ++ + + L QI G+ Y+ N +HRDL+ +N+L+ N Sbjct: 263 MNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVC 322 Query: 204 KICDFGLARVTSESDFMTEYVVTRW--YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-R 260 K+ DFGLAR+ ++++ + APE L +T DVWS G + EL Sbjct: 323 KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKG 381 Query: 261 KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPL 320 + +PG + L + P P Sbjct: 382 RVPYPGMVNREVLDQVERGYRMPCP-----------------------------PECPES 412 Query: 321 AIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFN 365 DL+ + +P R T A + S EP+ N Sbjct: 413 LHDLMCQCWRKEPEERPTFEYLQA---FLEDYFTSTEPQYQPGEN 454 >4U41-A nrPDB Length = 332 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 125/329 (37%), Gaps = 44/329 (13%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 124 + +G G YG V + +T + AIK + D + + K EI +L+ H NI Sbjct: 29 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRNIAT 85 Query: 125 IRDIIPPPLRNAFND-VYIAYELMD-TDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYI 180 +D +++ E + ++++ + L E+ Y +ILRGL ++ Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES-DFMTEYVVTRWYRAPELLLNSS 239 H +V+HRD+K N+LL N ++K+ DFG++ + ++ T ++ APE++ Sbjct: 146 HIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 205 Query: 240 D----YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + Y D+WS G +E+ + P +H +R L + P Sbjct: 206 NPDATYDYRSDLWSCGITAIEMAEGAPP---LCDMHPMRALFLIPRNPPPRLKSKKWSKK 262 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355 IE L + +R + L HP++ D Sbjct: 263 FFSF-------------------------IEGCLVKNYMQRPSTEQLLKHPFI---RDQP 294 Query: 356 DEPECTIPFNFDFENHALSEEQMKELIYR 384 +E + I + + E Y Sbjct: 295 NERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >5O2B-A nrPDB Length = 285 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 127/296 (42%), Gaps = 35/296 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + ++ + +G+GA+ V +++ET VA ++ + K + +R E ++L+ + Sbjct: 14 SGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQ 73 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV D L+ + + ELM L ++ + + + + + QIL+GL Sbjct: 74 HPNIVRFYDSWESILKGKKC-IVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGL 132 Query: 178 KYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +++H+ ++HRDLK N+ + +KI D GLA + + F + T + APE Sbjct: 133 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM-RTSFAKSVIGTPEFMAPE- 190 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y ++DV++ G +E+ + + + Q+ Sbjct: 191 -MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI--------------------- 228 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 ++ + P +TD P ++IE + + R+++ D L H + Sbjct: 229 YRKVTSGIKPASFNKVTD------PEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >4PWN-A nrPDB Length = 274 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 131/315 (41%), Gaps = 50/315 (15%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S+ GRF++++I IG+G++ V +++ET VA ++ + Sbjct: 5 MSNDGRFLKFDI----------------EIGRGSFKTVYKGLDTETTVEVAWCELQDRKL 48 Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN 158 K + +R E ++L+ + H NIV D ++ + + ELM L ++ Sbjct: 49 TKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKC-IVLVTELMTSGTLKTYLKRF 107 Query: 159 QALSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTS 215 + + + + + QIL+GL+++H+ ++HRDLK N+ + +KI D GLA + Sbjct: 108 KVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEK 167 Query: 216 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 + F + T + APE + Y ++DV++ G +E+ + + + Q+ Sbjct: 168 RASFAKSVIGTPEFMAPE--MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI-- 223 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 +R + P + P ++IE + + Sbjct: 224 -------------------YRRVTSGVKPASFDKVAI------PEVKEIIEGCIRQNKDE 258 Query: 336 RITVLDALAHPYLNS 350 R ++ D L H + Sbjct: 259 RYSIKDLLNHAFFQE 273 >3PFQ-A nrPDB Length = 674 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 68/375 (18%), Positives = 136/375 (36%), Gaps = 58/375 (15%) Query: 2 DGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAK 61 +G G + A G AP + + +++ GN + Sbjct: 294 EGSEGNEELRQKFERAKIGQGTKAPEEKTANTIS------------KFDNNGNRDRMKLT 341 Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKRTLREIKLLRH-MDH 119 +M +GKG++G V + T+E A+K + D + T+ E ++L Sbjct: 342 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 401 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 + + R +Y E + DL I+ E H ++ +I GL Sbjct: 402 PFLTQLHSCFQTMDR-----LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 179 YIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLN 237 ++ S +++RDLK N++L++ +KI DFG+ + + + T Y APE++ Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA- 515 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR 297 Y ++D W+ G + E++ + F G D + +ME + Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK------------ 563 Query: 298 YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV-----LDALAHPYLNSLH 352 ++ A+ + + ++T P +R+ D H + + Sbjct: 564 ------------------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 605 Query: 353 -DISDEPECTIPFNF 366 + + E P+ Sbjct: 606 WEKLERKEIQPPYKP 620 >5O2C-A nrPDB Length = 380 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 127/296 (42%), Gaps = 35/296 (11%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 118 + ++ + +G+GA+ V +++ET VA ++ + K + +R E ++L+ + Sbjct: 23 SGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQ 82 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 H NIV D L+ + + ELM L ++ + + + + + QIL+GL Sbjct: 83 HPNIVRFYDSWESILKGKKC-IVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGL 141 Query: 178 KYIHSAN--VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 +++H+ ++HRDLK N+ + +KI D GLA + + F + T + APE Sbjct: 142 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM-RTSFAKSVIGTPEFMAPE- 199 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + Y ++DV++ G +E+ + + + Q+ Sbjct: 200 -MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI--------------------- 237 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 ++ + P +TD P ++IE + + R+++ D L H + Sbjct: 238 YRKVTSGIKPASFNKVTD------PEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >6CCF-A nrPDB Length = 290 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 136/318 (42%), Gaps = 59/318 (18%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN----------------------- 96 +YK IGKGAYG+V A N + A+K ++ Sbjct: 5 NQYKLQ-SEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 97 -AFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQII 155 + +R +EI +L+ +DH N+V + +++ P + ++Y+ ++L+ + Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAED---NLYLVFDLLRKGPVMEV 120 Query: 156 RSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 215 ++ SEE + +L ++ GL+Y+H ++HRD+KPSNLLL + +KI DFG++ Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 216 ESDF-MTEYVVTRWYRAPELLLNSS--DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 +D ++ T + APE + +S A+DVW+ G + K F Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-------- 232 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 +++ R++ P + P + DLI KML + Sbjct: 233 ------------------IDDFILALHRKIKNEPVVFPEE--PEISEELKDLILKMLDKN 272 Query: 333 PRRRITVLDALAHPYLNS 350 P RI V D HP++ Sbjct: 273 PETRIGVPDIKLHPWVTK 290 >6ED6-A nrPDB Length = 415 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 116/303 (38%), Gaps = 41/303 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLR 115 ++ A+ + IG+GA+G V + + + A+K ++ + D+ E ++ Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILR 175 + +V + +Y+ E M + SN + E+ +++ +++ Sbjct: 144 FANSPWVVQLFYAFQDDRY-----LYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVL 198 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM--TEYVVTRWYRAPE 233 L IHS ++HRD+KP N+LL+ + LK+ DFG E+ + V T Y +PE Sbjct: 199 ALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPE 258 Query: 234 LLLNSSD---YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 +L + Y D WSVG E++ F V +M+ Sbjct: 259 VLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD------------ 306 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDALAHPY 347 + P + A +LI LT D R+ V + HP+ Sbjct: 307 -----HKNSLCFPEDAE---------ISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPF 351 Query: 348 LNS 350 + Sbjct: 352 FKN 354 >5SYS-A nrPDB Length = 286 Score = 214 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 68/328 (20%), Positives = 119/328 (36%), Gaps = 49/328 (14%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 G + + +E+ + + +G+G +G + T VAIK + + Sbjct: 1 GHMQTQGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPG---TMS 56 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS--NQA 160 + L+E ++++ + HE +V + ++ +YI E M L ++ + Sbjct: 57 PEAFLQEAQVMKKLRHEKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGEMGKY 110 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 L QI G+ Y+ N +HRDL+ +N+L+ N K+ DFGLAR+ ++++ Sbjct: 111 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 170 Query: 221 TEYVVTRW--YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLM 277 + APE L +T DVWS G + EL + +PG + L + Sbjct: 171 ARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 229 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 P P DL+ + DP R Sbjct: 230 RGYRMPCP-----------------------------PECPESLHDLMCQCWRKDPEERP 260 Query: 338 TVLDALAHPYLNSLHDISDEPECTIPFN 365 T A + S EP+ N Sbjct: 261 TFEYLQA---FLEDYFTSTEPQYQPGEN 285 >6E9W-A nrPDB Length = 443 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 124/341 (36%), Gaps = 53/341 (15%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHM 117 A+ + IG+GA+G V + T + A+K ++ + D+ E ++ Sbjct: 100 KAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 159 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGL 177 + +V + +Y+ E M + SN + E+ +++ +++ L Sbjct: 160 NSPWVVQLFYAFQDDRY-----LYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLAL 214 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT--EYVVTRWYRAPELL 235 IHS +HRD+KP N+LL+ + LK+ DFG ++ + V T Y +PE+L Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 236 L---NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 Y D WSVG E++ F V +M + L F + Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN-----HKNSLTFPD 329 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDALAHPYLN 349 +N + A +LI LT D R+ V + H + Sbjct: 330 DN---------------------DISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFK 367 Query: 350 S----LHDISDEPECTIP--------FNFDFENHALSEEQM 378 + + D +P NFD EE+ Sbjct: 368 NDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEET 408 >2I0E-A nrPDB Length = 353 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 126/329 (38%), Gaps = 46/329 (13%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF-DNKIDAKR 106 +++ GN + +M +GKG++G V + T+E A+K + D + Sbjct: 7 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 66 Query: 107 TLREIKLLRH-MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEE 164 T+ E ++L + + R +Y E + DL I+ E Sbjct: 67 TMVEKRVLALPGKPPFLTQLHSCFQTMDR-----LYFVMEYVNGGDLMYHIQQVGRFKEP 121 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEY 223 H ++ +I GL ++ S +++RDLK N++L++ +KI DFG+ + + + Sbjct: 122 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 181 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 T Y APE++ Y ++D W+ G + E++ + F G D + +ME Sbjct: 182 CGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAY 240 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV---- 339 + ++ A+ + + ++T P +R+ Sbjct: 241 PK------------------------------SMSKEAVAICKGLMTKHPGKRLGCGPEG 270 Query: 340 -LDALAHPYLNSLH-DISDEPECTIPFNF 366 D H + + + + E P+ Sbjct: 271 ERDIKEHAFFRYIDWEKLERKEIQPPYKP 299 >1TKI-A nrPDB Length = 321 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 127/298 (42%), Gaps = 40/298 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 E+ KY +G+G +GIV + + + ++ K + +++ K+ EI +L Sbjct: 2 ELYEKYMIA-EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNI 57 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQIL 174 H NI+ + + + ++ + +E + D+ + I ++ L+E +++Q+ Sbjct: 58 ARHRNILHLHESFE-----SMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFMTEYVVTRWYRAP 232 L+++HS N+ H D++P N++ +KI +FG AR D Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 E+ + + A D+WS+G + L+ F L Sbjct: 173 EVHQHDVV-STATDMWSLGTLVYVLLSGINPF--------------------------LA 205 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 E ++ I + + F + A+D ++++L + + R+T +AL HP+L Sbjct: 206 ETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >3TKU-A nrPDB Length = 433 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 130/345 (37%), Gaps = 53/345 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK-LL 114 ++ + I IG+GA+G V T A+K + K RE + +L Sbjct: 85 MQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVL 144 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQII-RSNQALSEEHCQYFLYQ 172 + D + I A+ N +Y+ + + DL ++ + L E+ ++++ + Sbjct: 145 VNGDCQWITALHYAFQDE-----NHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGE 199 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY--VVTRWYR 230 ++ + IH + +HRD+KP N+LL+ N +++ DFG ++ + V T Y Sbjct: 200 MVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYI 259 Query: 231 APELLL----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 +PE+L Y D WS+G E++ + F V +M Sbjct: 260 SPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-------- 311 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDAL 343 R V A DLI++++ RR+ + D Sbjct: 312 -----------------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIEDFK 353 Query: 344 AHPYLNSLH-------DISDEPECTIP---FNFDFENHALSEEQM 378 H + L+ + P+ + P NFD ++ L ++ Sbjct: 354 KHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEI 398 >4EBW-A nrPDB Length = 304 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 113/295 (38%), Gaps = 45/295 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETN---ESVAIKKIANAFDNKIDAKRTLREIK 112 +E+ + IG+G +G V + +VAIK N + + ++ L+E Sbjct: 33 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSV-REKFLQEAL 91 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR-SNQALSEEHCQYFL 170 +R DH +IV + +I N V+I EL +L ++ +L + Sbjct: 92 TMRQFDHPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYA 145 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 YQ+ L Y+ S +HRD+ N+L+++N +K+ DFGL+R +S + Sbjct: 146 YQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 205 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFME-LMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 + APE + N +T+A DVW G E LM F G + + + P Sbjct: 206 WMAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP-- 262 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 P P L+ K +DP RR + Sbjct: 263 ---------------------------PNCPPTLYSLMTKCWAYDPSRRPRFTEL 290 >5VO2-A nrPDB Length = 300 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 48/294 (16%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 +++EV + + +G GA G V E VA+KK+ + + IK Sbjct: 5 DLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------IKH 53 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQ 172 LR + H NI+ + + I E L++++R+ + ++ + Sbjct: 54 LRKLKHPNIITFKGVCTQAPCY-----CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG 108 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAP 232 I G+ Y+H ++HRDLK N+L+ + +KI DFG ++ S+ + T + AP Sbjct: 109 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAP 168 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 E++ N + +D+WS G + EL+ + + D + + Sbjct: 169 EVIRNEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV---------------- 211 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAID-LIEKMLTFDPRRRITVLDALAH 345 S+ P+ P L+ + PR R + L H Sbjct: 212 -------------GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >2DQ7-X nrPDB Length = 283 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 121/319 (37%), Gaps = 49/319 (15%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 +++E+ + I +G G +G V + N VAIK + + + L E + Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPG---TMSPESFLEEAQ 56 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYF 169 +++ + H+ +V + ++ +YI E M+ L ++ +AL + Sbjct: 57 IMKKLKHDKLVQLYAVVSEE------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDM 110 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW- 228 Q+ G+ YI N +HRDL+ +N+L+ KI DFGLAR+ ++++ Sbjct: 111 AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 170 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE L +T DVWS G + EL+ + +PG ++ L + P + Sbjct: 171 KWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ 229 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 346 + +L+ DP R T + Sbjct: 230 DCPI-----------------------------SLHELMIHCWKKDPEERPTFEYLQS-- 258 Query: 347 YLNSLHDISDEPECTIPFN 365 + + EP+ N Sbjct: 259 -FLEDYFTATEPQYQPGEN 276 >2FO0-A nrPDB Length = 495 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 131/337 (38%), Gaps = 51/337 (15%) Query: 33 IENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK 92 + PA + + + +E+ +G G YG V + + + +VA+K Sbjct: 189 TLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK 248 Query: 93 KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDL 151 + ++ ++ + L+E +++ + H N+V + + YI E M +L Sbjct: 249 TLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREP-----PFYIITEFMTYGNL 300 Query: 152 HQIIRS--NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 +R Q ++ Y QI ++Y+ N +HR+L N L+ N +K+ DFG Sbjct: 301 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFG 360 Query: 210 LARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFP 265 L+R+ + D T + ++ + APE L + ++ DVW+ G + E+ +P Sbjct: 361 LSRLMT-GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP 418 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 G D LL K Y + P + + + L+ Sbjct: 419 GIDLSQVYELLE------------------KDYRMERPEGCPEKVYE-----------LM 449 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSL---HDISDEPE 359 ++P R + + H ++ ISDE E Sbjct: 450 RACWQWNPSDRPSFAEI--HQAFETMFQESSISDEVE 484 >4XEY-B nrPDB Length = 408 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 131/337 (38%), Gaps = 51/337 (15%) Query: 33 IENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK 92 + PA + + + +E+ +G G YG V + + + +VA+K Sbjct: 97 TLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK 156 Query: 93 KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDL 151 + ++ ++ + L+E +++ + H N+V + + YI E M +L Sbjct: 157 TLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREP-----PFYIITEFMTYGNL 208 Query: 152 HQIIRS--NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 +R Q ++ Y QI ++Y+ N +HRDL N L+ N +K+ DFG Sbjct: 209 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 268 Query: 210 LARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFP 265 L+R+ + D T + ++ + APE L + ++ DVW+ G + E+ +P Sbjct: 269 LSRLMT-GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP 326 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 G D LL K Y + P + + + L+ Sbjct: 327 GIDLSQVYELLE------------------KDYRMERPEGCPEKVYE-----------LM 357 Query: 326 EKMLTFDPRRRITVLDALAHPYLNSL---HDISDEPE 359 ++P R + + H ++ ISDE E Sbjct: 358 RACWQWNPSDRPSFAEI--HQAFETMFQESSISDEVE 392 >5UNP-A nrPDB Length = 369 Score = 211 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 143/338 (42%), Gaps = 44/338 (13%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAM-NSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 + +Y+ + +G+G +G V + + VA+K I N K A+ + ++ + Sbjct: 31 WLQERYEI-VSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKIN 89 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE--HCQYFLYQI 173 D +N + + + I++EL+ ++ N L ++ +Q+ Sbjct: 90 EKDPDN--KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLN-------------------ANCDLKICDFGLARVT 214 + +K++H + H DLKP N+L + +++ DFG A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF- 206 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 + + + V TR YRAPE++L ++ DVWS+GCI E LF D+ L Sbjct: 207 -DHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 275 LLMELIGTPSEEELEFL---------------NENAKRYIRQLPPYPRQSITDKFPTVHP 319 ++ ++G + N +A RY+R+ R+ +T + H Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQ 324 Query: 320 LAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDE 357 L DLIE ML ++P +R+T+ +AL HP+ L Sbjct: 325 L-FDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >4KIK-B nrPDB Length = 677 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 79/280 (28%), Positives = 116/280 (41%), Gaps = 16/280 (5%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G G +G V N ET E +AIK+ + + +R EI+++R + H N+VA R Sbjct: 25 ERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPR-NRERWCLEIQIMRRLTHPNVVAAR 83 Query: 127 DIIPPPLRNAFNDV-YIAYELM-DTDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIH 181 D+ A ND+ +A E DL + + + L E L I L+Y+H Sbjct: 84 DVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLH 143 Query: 182 SANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 238 ++HRDLKP N++L KI D G A+ + T +V T Y APE LL Sbjct: 144 ENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE-LLEQ 202 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 YT +D WS G + E + F Q + E LN K Sbjct: 203 QKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVK-- 260 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 PYP + + ++ ML + PR+R T Sbjct: 261 FSSSLPYPNNLNSVLAERLEKW----LQLMLMWHPRQRGT 296 >3C51-A nrPDB Length = 543 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 123/317 (38%), Gaps = 44/317 (13%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHM 117 + +G+G +G V + T + A KK+ K + + E K+L + Sbjct: 183 GEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKV 242 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQII----RSNQALSEEHCQYFLYQ 172 IV++ D+ + +M D+ I N E ++ Q Sbjct: 243 HSRFIVSLAYAFETK-----TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQ 297 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE-YVVTRWYRA 231 I+ GL+++H N+++RDLKP N+LL+ + +++I D GLA T+ Y T + A Sbjct: 298 IVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMA 357 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PELLL Y ++D +++G E++ + F R + + Sbjct: 358 PELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVENK----------------- 399 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHP 346 E +R + Q YP + P + D E +L DP +R+ + HP Sbjct: 400 -ELKQRVLEQAVTYPDKF--------SPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHP 450 Query: 347 YLNSLHDISDEPECTIP 363 + E P Sbjct: 451 LFRDISWRQLEAGMLTP 467 >6E2O-A nrPDB Length = 295 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 78/288 (27%), Positives = 125/288 (43%), Gaps = 39/288 (13%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +GKG YGIV + + +AIK+I + ++ EI L +H+ H+NIV Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPER--DSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QAL--SEEHCQYFLYQILRGLKYIHSAN 184 N F +++ ++ L ++RS L +E+ ++ QIL GLKY+H Sbjct: 87 SFSE---NGFIKIFME-QVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 142 Query: 185 VLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTE-YVVTRWYRAPELL-LNSSDY 241 ++HRD+K N+L+N + LKI DFG ++ + + TE + T Y APE++ Y Sbjct: 143 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY 202 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 A D+WS+GC +E+ KP F +G P + + Sbjct: 203 GKAADIWSLGCTIIEMATGKPPFYE-------------LGEPQAAMFKV------GMFKV 243 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 P P ++ A I K DP +R D L +L Sbjct: 244 HPEIPE--------SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >3M42-A nrPDB Length = 299 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 78/335 (23%), Positives = 126/335 (37%), Gaps = 67/335 (20%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL-RH 116 + YK +G G G V N T E A+K + D + RE++L R Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRA 67 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQI 173 +IV I D+ L + I E +D +L I R +QA +E + I Sbjct: 68 SQCPHIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------- 171 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 Y + D+WS+G I L+ P F H L + + + EF Sbjct: 172 -------GEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEF 221 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 N ++ V LI +L +P +R+T+ + + HP++ Sbjct: 222 PNP-------------------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 262 Query: 351 LHDISDEPECTIPFNFDFENHALSEEQMKELIYRE 385 + P + L E++ + +E Sbjct: 263 STKVPQTPL--------HTSRVLKEDKERWEDVKE 289 >4IAN-A nrPDB Length = 358 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 86/338 (25%), Positives = 159/338 (47%), Gaps = 51/338 (15%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSET-NESVAIKKIANAFDNKIDAKRTLREIK 112 NI EV K G+G + V A ++ N+ VA+K I N N++ K L+E++ Sbjct: 23 NIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN---NELMQKTGLKELE 79 Query: 113 LLRHMDHE------NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSE 163 L+ ++ + + + + + +E + +L ++++ + L Sbjct: 80 FLKKLNDADPDDKFHCLRLFRHFYHK-----QHLCLVFEPLSMNLREVLKKYGKDVGLHI 134 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDL-KICDFGLARVTSESDFMTE 222 + + + Q+ LK + N+LH D+KP N+L+N + + K+CDFG A +++D +T Sbjct: 135 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITP 193 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 Y+V+R+YRAPE+++ S Y ID+WSVGC EL K LFPG+ + H L+L M+L G Sbjct: 194 YLVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGK 252 Query: 283 PSEEEL-------EFLNENAKRYIRQLPPYPRQSITDKFPTVHP---------------- 319 + + + ++N ++ + T++P Sbjct: 253 MPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPE 312 Query: 320 -------LAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 DL++++L DP +RI++ AL H ++ Sbjct: 313 DQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >2XNP-A nrPDB Length = 279 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 120/300 (40%), Gaps = 44/300 (14%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 A+ + IG G+YG + + K++ + + + + E+ LLR + H Sbjct: 5 AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQII----RSNQALSEEHCQYFLYQIL 174 NIV D I +YI E + DL +I + Q L EE + Q+ Sbjct: 65 PNIVRYYDRIIDRTN---TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 175 RGLKYIHSAN-----VLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRW 228 LK H + VLHRDLKP+N+ L+ ++K+ DFGLAR+ ++ F +V T + Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 Y +PE + N Y D+WS+GC+ EL P F + E Sbjct: 182 YMSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIRE---------- 230 Query: 289 EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 + PY ++I +ML R +V + L +P + Sbjct: 231 ---------GKFRRIPYRY----------SDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >6NPU-A nrPDB Length = 298 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 67/316 (21%), Positives = 126/316 (39%), Gaps = 51/316 (16%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +E+ +G G YG V + + + +VA+K + ++ ++ + L+E + Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAV 75 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS--NQALSEEHCQYFL 170 ++ + H N+V + + YI E M +L +R Q ++ Y Sbjct: 76 MKEIKHPNLVQLLGVCTREP-----PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 130 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 QI ++Y+ N +HRDL N L+ N +K+ DFGL+R+ + D T + ++ Sbjct: 131 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPI 189 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE L + ++ DVW+ G + E+ +PG D LL Sbjct: 190 KWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE--------- 239 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 346 K Y + P + + + L+ ++P R + + H Sbjct: 240 ---------KDYRMERPEGCPEKVYE-----------LMRACWQWNPSDRPSFAEI--HQ 277 Query: 347 YLNSL---HDISDEPE 359 ++ ISDE E Sbjct: 278 AFETMFQESSISDEVE 293 >3QA8-A nrPDB Length = 676 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 76/306 (24%), Positives = 133/306 (43%), Gaps = 45/306 (14%) Query: 55 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 +E+ + +G G +G V ++ +T E VAIK+ K + +R EI+++ Sbjct: 15 PWEMKER-------LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPK-NRERWCLEIQIM 66 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDV-YIAYELMDT-DLHQIIRSNQ---ALSEEHCQYF 169 + ++H N+V+ R++ + A ND+ +A E + DL + + + L E + Sbjct: 67 KKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTL 126 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCD---LKICDFGLARVTSESDFMTEYVVT 226 L I L+Y+H ++HRDLKP N++L KI D G A+ + + TE+V T Sbjct: 127 LSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGT 186 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 Y APE LL YT +D WS G + E + F P+ + Sbjct: 187 LQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPF-----------------LPNWQ 228 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL-----------IEKMLTFDPRR 335 +++ + ++ + Y + KF +V P L ++ ML + R+ Sbjct: 229 PVQWHGKVREKSNEHIVVYDDLTGAVKFSSVLPTPNHLSGILAGKLERWLQCMLMWHQRQ 288 Query: 336 RITVLD 341 R T Sbjct: 289 RGTDPQ 294 >4AW2-A nrPDB Length = 437 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 128/345 (37%), Gaps = 53/345 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK-LL 114 + + + IG+GA+G V ++ A+K + K RE + +L Sbjct: 69 MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVL 128 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQII-RSNQALSEEHCQYFLYQ 172 + D + I + N++Y+ + + DL ++ + L EE +++L + Sbjct: 129 VNGDSKWITTLHYAFQDD-----NNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAE 183 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY--VVTRWYR 230 ++ + +H + +HRD+KP N+L++ N +++ DFG E + V T Y Sbjct: 184 MVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYI 243 Query: 231 APELLL----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 +PE+L Y D WS+G E++ + F V +M Sbjct: 244 SPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-------- 295 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDAL 343 R + V A DLI +++ R+ + D Sbjct: 296 -----------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGIEDFK 337 Query: 344 AHPYLNSLH-------DISDEPECTIP---FNFDFENHALSEEQM 378 HP+ + + + PE + P NFD ++ L + Sbjct: 338 KHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSET 382 >2J0K-A nrPDB Length = 656 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 113/295 (38%), Gaps = 45/295 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETN---ESVAIKKIANAFDNKIDAKRTLREIK 112 +E+ + IG+G +G V + +VAIK N + + ++ L+E Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSV-REKFLQEAL 443 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFL 170 +R DH +IV + +I N V+I EL +L ++ + +L + Sbjct: 444 TMRQFDHPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYA 497 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 YQ+ L Y+ S +HRD+ N+L++A +K+ DFGL+R +S + Sbjct: 498 YQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 557 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFME-LMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 + APE + N +T+A DVW G E LM F G + + + P Sbjct: 558 WMAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP-- 614 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 P P L+ K +DP RR + Sbjct: 615 ---------------------------PNCPPTLYSLMTKCWAYDPSRRPRFTEL 642 >2WQN-A nrPDB Length = 310 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 29/279 (10%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMDHENIVAI 125 IG+G + V A VA+KK+ A+ ++EI LL+ ++H N++ Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97 Query: 126 RDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS----NQALSEEHCQYFLYQILRGLKYI 180 N++ I EL D DL ++I+ + + E + Q+ L+++ Sbjct: 98 YASFIED-----NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE-SDFMTEYVVTRWYRAPELLLNSS 239 HS V+HRD+KP+N+ + A +K+ D GL R S + V T +Y +PE + + Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRD-HVHQLRLLMELIGTPSEEELEFLNENAKRY 298 Y D+WS+GC+ E+ + F G +++ L +E P + E + Sbjct: 213 -YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 + P P + + +D +R+ Sbjct: 272 NMCINPDPEKRPDVTY---------------VYDVAKRM 295 >3PPZ-A nrPDB Length = 309 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 124/313 (39%), Gaps = 47/313 (15%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G+ ++ IG G++G V A VA+K + + LRE+ Sbjct: 29 GDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVA 86 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS---NQALSEEHCQY 168 +++ + H NIV + P ++ I E + L++++ + L E Sbjct: 87 IMKRLRHPNIVLFMGAVTQPP-----NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLS 141 Query: 169 FLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-MTEYVV 225 Y + +G+ Y+H+ N ++HRDLK NLL++ +K+CDFGL+R+ + + Sbjct: 142 MAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAG 201 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 T + APE+L + DV+S G I EL + + + + + Sbjct: 202 TPEWMAPEVLRDEPS-NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAV--------- 251 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDA 342 + + PR ++P +IE T +P +R T++D Sbjct: 252 -----------GFKCKRLEIPR--------NLNPQVAAIIEGCWTNEPWKRPSFATIMDL 292 Query: 343 LAHPYLNSLHDIS 355 L P + S Sbjct: 293 LR-PLIKSAVPPP 304 >4XLV-A nrPDB Length = 328 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 71/363 (19%), Positives = 131/363 (36%), Gaps = 66/363 (18%) Query: 22 PAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS-- 79 P P P LS F + +EV+ + + +G+G++G+V Sbjct: 2 PDGPLGPLFASSN--PEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGN 59 Query: 80 AMNSETNE---SVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNA 136 A + E VA+K + N + + L E +++ ++V + ++ Sbjct: 60 ARDIIKGEAETRVAVKTV-NESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKG---- 114 Query: 137 FNDVYIAYELM-DTDLHQIIRSNQALSE----------EHCQYFLYQILRGLKYIHSANV 185 + ELM DL +RS + +E + +I G+ Y+++ Sbjct: 115 -QPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKF 173 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM----TEYVVTRWYRAPELLLNSSDY 241 +HRDL N ++ + +KI DFG+ R E+D+ + RW APE L + + Sbjct: 174 VHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW-MAPESLKD-GVF 231 Query: 242 TAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 T + D+WS G + E+ + + G + L+ +M+ Sbjct: 232 TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD---------------------- 269 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA------HPYLNSLHDI 354 D+ DL+ F+P R T L+ + HP + Sbjct: 270 -------GGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFF 322 Query: 355 SDE 357 E Sbjct: 323 HSE 325 >4OLI-A nrPDB Length = 645 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 115/310 (37%), Gaps = 33/310 (10%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIV----CSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 + +Y I +G+G +G V N T E VA+K + + + Sbjct: 346 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQ 404 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQY 168 EI +LR + HE+I+ + + + E + L + + ++ Sbjct: 405 EIDILRTLYHEHIIKYKGCCEDQGEKSLQ---LVMEYVPLGSLRDYLPRH-SIGLAQLLL 460 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY----- 223 F QI G+ Y+HS + +HR+L N+LL+ + +KI DFGLA+ E Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGD 520 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 WY APE L Y A DVWS G EL+ +ELIG Sbjct: 521 SPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIGIA 573 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 + R L R DK P L++ + R T + + Sbjct: 574 QGQM------TVLRLTELLERGERLPRPDKCPC---EVYHLMKNCWETEASFRPTFENLI 624 Query: 344 AHPYLNSLHD 353 P L ++H+ Sbjct: 625 --PILKTVHE 632 Score = 92.0 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 87/275 (31%), Gaps = 50/275 (18%) Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFND 139 + V +K + + + A L+ + H ++ + + N Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENI--- 142 Query: 140 VYIAYELMDTDLHQ--IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 + E ++ + R + Q+ L Y+ + N++H ++ N+LL Sbjct: 143 --MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 200 Query: 198 -------NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-SDYTAAIDVWS 249 + +K+ D G+ + E + + APE L + + A+D W Sbjct: 201 ARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWG 257 Query: 250 VGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQS 309 G +E+ F G P + E+ + +LP Sbjct: 258 FGATLLEIC-----FDGE--------------APLQSRSPSEKEHFYQRQHRLPE----- 293 Query: 310 ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 P L + LT++P +R + L Sbjct: 294 ------PSCPQLATLTSQCLTYEPTQRPSFRTILR 322 >4GS6-A nrPDB Length = 315 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 80/317 (25%), Positives = 132/317 (41%), Gaps = 56/317 (17%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G++ + K +G+GA+G+VC A + VAIK+I +++ + K + E++ Sbjct: 1 GSLHMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELR 54 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALS---EEHCQY 168 L ++H NIV + N V + E + L+ ++ + L H Sbjct: 55 QLSRVNHPNIVKLYGAC-------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 107 Query: 169 FLYQILRGLKYIHSAN---VLHRDLKPSNLLLNANCDL-KICDFGLARVTSESDFMTEYV 224 + Q +G+ Y+HS ++HRDLKP NLLL A + KICDFG A MT Sbjct: 108 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNK 165 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 + + APE+ S+Y+ DV+S G I E++ R+ F E+ G Sbjct: 166 GSAAWMAPEV-FEGSNYSEKCDVFSWGIILWEVITRRKPFD------------EIGGPAF 212 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD--- 341 N I+ LP L+ + + DP +R ++ + Sbjct: 213 RIMWAVHNGTRPPLIKNLPKPIE---------------SLMTRCWSKDPSQRPSMEEIVK 257 Query: 342 ALAHPYLNSLHDISDEP 358 + H L +DEP Sbjct: 258 IMTH--LMRYFPGADEP 272 >5UUU-A nrPDB Length = 547 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 84/403 (20%), Positives = 148/403 (36%), Gaps = 64/403 (15%) Query: 8 PAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHG--GRFIQYNIFGNIFE-------- 57 + TE + G P P IE I L +FI+ + F + Sbjct: 134 SKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNI 193 Query: 58 -VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLR 115 +T IG+G +G V ++T + A+K + + L E +++ Sbjct: 194 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIML 252 Query: 116 HM----DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLY 171 + D IV + P + +F I + DLH + + SE +++ Sbjct: 253 SLVSTGDCPFIVCMSYAFHTPDKLSF----ILDLMNGGDLHYHLSQHGVFSEADMRFYAA 308 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 +I+ GL+++H+ V++RDLKP+N+LL+ + ++I D GLA S+ V T Y A Sbjct: 309 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMA 367 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE+L Y ++ D +S+GC+ +L+ F + + + T + E + Sbjct: 368 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF 426 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHP 346 P L+E +L D RR+ + P Sbjct: 427 --------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 460 Query: 347 YLNSLH----------DISDEPECTIPFNFDFENHALSEEQMK 379 + SL P + F+ + EE K Sbjct: 461 FFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >6DBM-A nrPDB Length = 318 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 119/321 (37%), Gaps = 33/321 (10%) Query: 43 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIV----CSAMNSETNESVAIKKIANAF 98 G + + G+ +Y I +G+G +G V N T E VA+K + A Sbjct: 13 GALEVLFQGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-AD 71 Query: 99 DNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS 157 +EI +LR + HE+I+ + + + E + L + Sbjct: 72 AGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQ---LVMEYVPLGSLRDYLPR 128 Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES 217 + ++ F QI G+ Y+HS + +HRDL N+LL+ + +KI DFGLA+ E Sbjct: 129 H-SIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEG 187 Query: 218 DFMTEY-----VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 WY APE L Y A DVWS G EL+ Sbjct: 188 HEYYRVREDGDSPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSP 240 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 +ELIG + R L R DK P L++ + Sbjct: 241 PTKFLELIGIAQGQM------TVLRLTELLERGERLPRPDKCPA---EVYHLMKNCWETE 291 Query: 333 PRRRITVLDALAHPYLNSLHD 353 R T + + P L ++H+ Sbjct: 292 ASFRPTFENLI--PILKTVHE 310 >2XYN-A nrPDB Length = 292 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 118/305 (38%), Gaps = 46/305 (15%) Query: 44 GRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID 103 G Y + +E+ +G G YG V + + + +VA+K + ++ ++ Sbjct: 15 GTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTME 71 Query: 104 AKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRS--NQA 160 + L+E +++ + H N+V + + YI E M +L +R + Sbjct: 72 VEEFLKEAAVMKEIKHPNLVQLLGVCTLEP-----PFYIVTEYMPYGNLLDYLRECNREE 126 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 ++ Y QI ++Y+ N +HRDL N L+ N +K+ DFGL+R+ + D Sbjct: 127 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTY 185 Query: 221 TEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLL 276 T + ++ + APE L + ++ DVW+ G + E+ +PG D LL Sbjct: 186 TAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLL 244 Query: 277 MELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 K Y + P P +L+ + P R Sbjct: 245 E------------------KGYRMEQPEGC-----------PPKVYELMRACWKWSPADR 275 Query: 337 ITVLD 341 + + Sbjct: 276 PSFAE 280 >4YHJ-A nrPDB Length = 584 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 123/332 (37%), Gaps = 42/332 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRH 116 VT +GKG +G VC+ T + A KK+ K + L E ++L Sbjct: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRG 176 + +V++ ++A V D H N E+ ++ ++ G Sbjct: 242 VQSRFVVSL--AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCG 299 Query: 177 LKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLL 236 L+ + +++RDLKP N+LL+ ++I D GLA E + V T Y APE++ Sbjct: 300 LEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVV- 358 Query: 237 NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 N+ YT + D W +GC+ E++ F + + + I +EE E Sbjct: 359 NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKF----- 413 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSL 351 A + +LT +P +R+ HP + Sbjct: 414 ---------------------SEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI 452 Query: 352 H------DISDEPECTIPFNFDFENHALSEEQ 377 + ++ + P C P + L EQ Sbjct: 453 NFRRLEANMLEPPFCPDPHAV-YCKDVLDIEQ 483 >4C59-A nrPDB Length = 340 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 66/332 (19%), Positives = 124/332 (37%), Gaps = 58/332 (17%) Query: 35 NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKI 94 ++P +L Q + G E+ + +G + V A + + A+K++ Sbjct: 1 SMPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 60 Query: 95 ANAFDNKIDAKRTLREIKLLRHMD-HENIVAIR---DIIPPPLRNAFNDVYIAYELMDTD 150 + + K + ++E+ ++ + H NIV I + + EL Sbjct: 61 LSNEEEKN--RAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQ 118 Query: 151 LHQIIR---SNQALSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKI 205 L + ++ S LS + YQ R ++++H ++HRDLK NLLL+ +K+ Sbjct: 119 LVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKL 178 Query: 206 CDFGLARVTSESDFMT-------------EYVVTRWYRAPELLLNSSDY--TAAIDVWSV 250 CDFG A S + T YR PE++ S++ D+W++ Sbjct: 179 CDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWAL 238 Query: 251 GCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSI 310 GCI L R+ F + +LR++ P + + + Sbjct: 239 GCILYLLCFRQHPF---EDGAKLRIVNGKYSIPPHDTQYTVFHS---------------- 279 Query: 311 TDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 LI ML +P R+++ + Sbjct: 280 -------------LIRAMLQVNPEERLSIAEV 298 >4IDT-A nrPDB Length = 356 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 81/377 (21%), Positives = 145/377 (38%), Gaps = 70/377 (18%) Query: 5 SGQPAADTEM--TEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKY 62 SGQ + T + T A G + PSP+ E + L+ + + Y + T + Sbjct: 23 SGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGV--LLTEKLKPVDYEYREEVHWATHQL 80 Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G+G++G V + +T A+KK+ ++ R E+ + I Sbjct: 81 R-----LGRGSFGEVHRMEDKQTGFQCAVKKVR------LEVFRAE-ELMACAGLTSPRI 128 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + + V I EL++ L Q+++ L E+ Y+L Q L GL+Y+H Sbjct: 129 VPLYGAVREGPW-----VNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLH 183 Query: 182 SANVLHRDLKPSNLLLNANC-DLKICDFGLARVTSESDFMTEYV------VTRWYRAPEL 234 S +LH D+K N+LL+++ +CDFG A + + T + APE+ Sbjct: 184 SRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEV 243 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 +L S A +DVWS C+ + +++ +F Sbjct: 244 VLGRS-CDAKVDVWSSCCMMLHMLNGCHP-----------------------WTQFFRGP 279 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA------------ 342 I PP + + P+ PL I++ L +P R++ + Sbjct: 280 LCLKIASEPP----PVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVG 335 Query: 343 -LAHPYLNSLHDISDEP 358 L P+ + P Sbjct: 336 GLKSPWRGEYKEPRHPP 352 >6GVJ-A nrPDB Length = 429 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 75/348 (21%), Positives = 130/348 (37%), Gaps = 49/348 (14%) Query: 22 PAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAM 81 P P+ I AT + + + V + + IG G V + Sbjct: 105 PYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVL 164 Query: 82 NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-H-ENIVAIRDIIPPPLRNAFND 139 N E + AIK + + EI L + H + I+ + D Sbjct: 165 N-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDY-----EITDQY 218 Query: 140 VYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA 199 +Y+ E + DL+ ++ +++ + + +L + IH ++H DLKP+N L+ Sbjct: 219 IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-V 277 Query: 200 NCDLKICDFGLARVTSESDF---MTEYVVTRWYRAPELLLNSSDY----------TAAID 246 + LK+ DFG+A V T Y PE + + S + D Sbjct: 278 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 337 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 VWS+GCI + K F ++Q+ L +I E+EF P P Sbjct: 338 VWSLGCILYYMTYGKTPFQ--QIINQISKLHAII--DPNHEIEF------------PDIP 381 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 354 + + D+++ L DP++RI++ + LAHPY+ Sbjct: 382 EKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 418 >4E93-A nrPDB Length = 377 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 121/336 (36%), Gaps = 50/336 (14%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 GFP+ P T G + + + + + + IG+G +G V S Sbjct: 74 GFPSIPLLIDHLLSTQQPLT-KKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFS 132 Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFND 139 N VA+K + AK L+E ++L+ H NIV + + Sbjct: 133 GRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVCTQK-----QP 186 Query: 140 VYIAYELM-DTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 +YI EL+ D +R+ L + + G++Y+ S +HRDL N L+ Sbjct: 187 IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV 246 Query: 198 NANCDLKICDFGLARVTSESDFMTE----YVVTRWYRAPELLLNSSDYTAAIDVWSVGCI 253 LKI DFG++R ++ + V +W APE L N Y++ DVWS G + Sbjct: 247 TEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPEAL-NYGRYSSESDVWSFGIL 304 Query: 254 FMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITD 312 E +P + + + P Sbjct: 305 LWETFSLGASPYPNLSNQQTREFVEKGGRLPC---------------------------- 336 Query: 313 KFPTVHPLA-IDLIEKMLTFDPRRRI---TVLDALA 344 P + P A L+E+ ++P +R T+ L Sbjct: 337 --PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 370 >5TQX-A nrPDB Length = 655 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 124/291 (42%), Gaps = 22/291 (7%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G +E+ + +G G +G VC + E + +AIK K + +R EI+ Sbjct: 7 GGPWEMRER-------LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-NRERWCHEIQ 58 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ---ALSEEHCQY 168 +++ ++H N+V D+ + +A E DL +++ + L E Sbjct: 59 IMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILS 118 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLL-NANCDL--KICDFGLARVTSESDFMTEYVV 225 L I G++Y+H ++HRDLKP N++L + + KI D G A+ + + TE+V Sbjct: 119 LLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVG 178 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 T Y APE L + YTA +D WS G + E + F H+ ++ + Sbjct: 179 TLQYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPF--LHHLQPFTWHEKIKKKDPK 235 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + + P P + + + ++ ML +DP++R Sbjct: 236 CIFACEEMSGEVRFSSHLPQPNSLCSLIVEPME----NWLQLMLNWDPQQR 282 >3PVW-A nrPDB Length = 695 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 71/333 (21%), Positives = 128/333 (38%), Gaps = 53/333 (15%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHM----DHEN 121 IG+G +G V ++T + A+K + + L E +++ + D Sbjct: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIMLSLVSTGDCPF 253 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 IV + P + +F I + DLH + + SE +++ +I+ GL+++H Sbjct: 254 IVCMSYAFHTPDKLSF----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 + V++RDLKP+N+LL+ + ++I D GLA S+ V T Y APE+L Y Sbjct: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAY 368 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 ++ D +S+GC+ +L+ F + + + T + E + Sbjct: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF---------- 417 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSLH---- 352 P L+E +L D RR+ + P+ SL Sbjct: 418 ----------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMV 461 Query: 353 ------DISDEPECTIPFNFDFENHALSEEQMK 379 P + F+ + EE K Sbjct: 462 FLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 >5KKR-C nrPDB Length = 395 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 126/312 (40%), Gaps = 24/312 (7%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + E+ I +G G G+V + + +A K I + + +RE+++ Sbjct: 61 KVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQV 119 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQ 172 L + IV + ++ I E MD L Q+++ + E+ Sbjct: 120 LHECNSPYIVGFYGAF-----YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 174 Query: 173 ILRGLKYI-HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 +++GL Y+ ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y + Sbjct: 175 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMS 233 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF- 290 PE L + Y+ D+WS+G +E+ + P D + + + E Sbjct: 234 PERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 292 Query: 291 -----------LNENAKRYIRQLPPYPRQSITDKFPTV--HPLAIDLIEKMLTFDPRRRI 337 ++ I +L Y K P+ D + K L +P R Sbjct: 293 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERA 352 Query: 338 TVLDALAHPYLN 349 + + H ++ Sbjct: 353 DLKQLMVHAFIK 364 >3EQC-A nrPDB Length = 360 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 68/339 (20%), Positives = 130/339 (38%), Gaps = 26/339 (7%) Query: 27 SPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 ++ +E F+ + E+ I +G G G+V + + Sbjct: 1 GKKLEELELDEQQRKRLEAFLTQKQ--KVGELKDDDFEKISELGAGNGGVVFKVSHKPSG 58 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 +A K I + + +RE+++L + IV + ++ I E Sbjct: 59 LVMARKLI-HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAF-----YSDGEISICMEH 112 Query: 147 MDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYI-HSANVLHRDLKPSNLLLNANCDLK 204 MD L Q+++ + E+ +++GL Y+ ++HRD+KPSN+L+N+ ++K Sbjct: 113 MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIK 172 Query: 205 ICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 +CDFG++ +S +V TR Y +PE L + Y+ D+WS+G +E+ + Sbjct: 173 LCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPI 230 Query: 265 PGRDHVHQLRLLMELIGTPSEEELEFLNENA----KRYIRQLPPYPRQSITDKFPTVHP- 319 P D + + + E K + PP + D P Sbjct: 231 PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPP 290 Query: 320 ---------LAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 D + K L +P R + + H ++ Sbjct: 291 KLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 329 >3A4O-X nrPDB Length = 286 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 116/266 (43%), Gaps = 21/266 (7%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + +E+ + + +G G +G V + + + VA+K + + + L E Sbjct: 5 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPG---TMSVQAFLEEAN 60 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA--LSEEHCQYF 169 L++ + H+ +V + ++ +YI E M L ++S++ + F Sbjct: 61 LMKTLQHDKLVRLYAVVTRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDF 115 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW- 228 QI G+ YI N +HRDL+ +N+L++ + KI DFGLARV ++++ Sbjct: 116 SAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 175 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTP--- 283 + APE + N +T DVWS G + E++ K +PGR + + L + P Sbjct: 176 KWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 Query: 284 --SEEELEFLNENAKRYIRQLPPYPR 307 +E + + K + P + Sbjct: 235 NCPDELYDIMKMCWKEKAEERPTFDY 260 >5H2U-A nrPDB Length = 267 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 116/294 (39%), Gaps = 44/294 (14%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 E + +G G +G V + + VAIK I+ DN + + EI+ ++ Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISR--DNLLHQQMLQSEIQAMK 57 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS--NQALSEEHCQYFLYQ 172 + H++I+A+ ++ + VYI ELM L +++R + L +Q Sbjct: 58 KLRHKHILALYAVVSVG-----DPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQ 112 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-YRA 231 + G+ Y+ S N +HRDL N+L+ N K+ DFGLAR+ E +++ + + A Sbjct: 113 VAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTA 172 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 PE L + Y+ DVWS G + E+ + +PG + + P E Sbjct: 173 PEAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLE--- 228 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 P L+ DP +R T AL Sbjct: 229 --------------------------CPPSVHKLMLTCWCRDPEQRPTFK-ALR 255 >6DBN-A nrPDB Length = 316 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 112/290 (38%), Gaps = 31/290 (10%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSE----TNESVAIKKIANAFDNKIDAKRTLREIKL 113 ++ I +G+G +G V T E VA+K + +EI++ Sbjct: 32 FEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGG-NHIADLKKEIEI 90 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQII-RSNQALSEEHCQYFLY 171 LR++ HENIV + I N + E + L + + ++ ++ + + Sbjct: 91 LRNLYHENIVKYKGICTEDGGNGIK---LIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV 147 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY-----VVT 226 QI +G+ Y+ S +HRDL N+L+ + +KI DFGL + Sbjct: 148 QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV 207 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 WY APE L+ S Y A DVWS G EL+ + L +++IG P+ Sbjct: 208 FWY-APECLMQSKFY-IASDVWSFGVTLHELLTYC-----DSDSSPMALFLKMIG-PTHG 259 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 ++ R + L R P L+ K F P R Sbjct: 260 QM-----TVTRLVNTLKEGKRLPCP---PNCPDEVYQLMRKCWEFQPSNR 301 >4E20-A nrPDB Length = 290 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 108/295 (36%), Gaps = 31/295 (10%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIV----CSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 + +Y I +G+G +G V N T E VA+K + ++ + R Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSG-WQR 59 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQY 168 EI++LR + HE+IV + + + E + L + + + Sbjct: 60 EIEILRTLYHEHIVKYKGCCEDQGEKSVQ---LVMEYVPLGSLRDYLPRH-CVGLAQLLL 115 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY----- 223 F QI G+ Y+H+ + +HR L N+LL+ + +KI DFGLA+ E Sbjct: 116 FAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGD 175 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 WY APE L Y A DVWS G EL+ + ELIG Sbjct: 176 SPVFWY-APECLKECKFY-YASDVWSFGVTLYELLTYC-----DSNQSPHTKFTELIGHT 228 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 + R L R D+ P L++ + R T Sbjct: 229 QGQM------TVLRLTELLERGERLPRPDRCPC---EIYHLMKNCWETEASFRPT 274 >3DLS-A nrPDB Length = 335 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 120/308 (38%), Gaps = 50/308 (16%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA------FDNKIDAKRTLRE 110 E + KY + P+G GA+G V +A++ E N+ V +K I + + E Sbjct: 21 EYSQKY-STMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLE 79 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT--DLHQIIRSNQALSEEHCQY 168 I +L ++H NI+ + DI + E + DL I + L E Y Sbjct: 80 IAILSRVEHANIIKVLDIFENQGFFQ-----LVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 Q++ + Y+ +++HRD+K N+++ + +K+ DFG A + T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIE 194 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 Y APE+L+ + +++WS+G L+ + F +L +E P Sbjct: 195 YCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPPY--- 245 Query: 289 EFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 V + L+ +L P RR T+ + P++ Sbjct: 246 ---------------------------LVSKELMSLVSGLLQPVPERRTTLEKLVTDPWV 278 Query: 349 NSLHDISD 356 +++D Sbjct: 279 TQPVNLAD 286 >4EQM-A nrPDB Length = 294 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 122/272 (44%), Gaps = 13/272 (4%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLR 115 + +YK + +G G V A ++ N VAIK I K + KR RE+ Sbjct: 8 IINERYKI-VDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSS 66 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQIL 174 + H+NIV++ D+ Y+ E ++ L + I S+ LS + F QIL Sbjct: 67 QLSHQNIVSMIDVDEEDDCY-----YLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQIL 121 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE--YVVTRWYRAP 232 G+K+ H ++HRD+KP N+L+++N LKI DFG+A+ SE+ + T Y +P Sbjct: 122 DGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSP 181 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 E + D++S+G + E++ +P F G V + + + + Sbjct: 182 EQAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSI--AIKHIQDSVPNVTTDVRK 238 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 + + + + +++ T+ + DL Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTIQEMKDDL 270 >4OTD-A nrPDB Length = 341 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 75/347 (21%), Positives = 133/347 (38%), Gaps = 48/347 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLRH 116 +T + + +G+G +G V + + E AIK + + + + + E ++L Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 117 M---DHENIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQIIRSNQALSEEHCQYFLYQ 172 + H +V + P V E DL I S+ SE ++ Sbjct: 69 VTSAGHPFLVNLFGCFQTP-----EHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSAC 122 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRA 231 ++ GL+++H +++RDLK NLLL+ +KI DFGL + D + + T + A Sbjct: 123 VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE+L ++S YT A+D W +G + E++ + FPG D ++ Sbjct: 183 PEVLTDTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN------------- 228 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHP 346 + RY R L AI ++ ++L +P RR+ D P Sbjct: 229 --DEVRYPRFL---------------SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQP 271 Query: 347 YLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEY 393 + +L + P + E EA +P Sbjct: 272 FFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 318 >2X7G-A nrPDB Length = 389 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 84/369 (22%), Positives = 142/369 (38%), Gaps = 84/369 (22%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 +Y I +G G + V + + VA+K + +A + + L EIKLL+ + Sbjct: 29 FNGRYHV-IRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSA---QHYTETALDEIKLLKCV 84 Query: 118 D-----HEN---IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQ 167 N +V + D N V + +E++ L + I + Q L + Sbjct: 85 RESDPSDPNKDMVVQLIDDFKISGMNGI-HVCMVFEVLGHHLLKWIIKSNYQGLPVRCVK 143 Query: 168 YFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNANC------------------------- 201 + Q+L+GL Y+HS ++H D+KP N+L+ + Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 202 ----------------------DLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 +KI D G A + TE + TR YR+ E+L+ + Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKH--FTEDIQTRQYRSIEVLIGAG 261 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRD------HVHQLRLLMELIGTPSEEE------ 287 Y+ D+WS C+ EL LF + ++EL+G+ Sbjct: 262 -YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKY 320 Query: 288 -LEFLNENAK-RYIRQLPPYPRQS-ITDKFPTVHPLA---IDLIEKMLTFDPRRRITVLD 341 EF N + R+I +L P+ + +K+ H A D + ML P +R + + Sbjct: 321 SREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGE 380 Query: 342 ALAHPYLNS 350 L HP+LNS Sbjct: 381 CLRHPWLNS 389 >4XCU-A nrPDB Length = 300 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 121/310 (39%), Gaps = 56/310 (18%) Query: 55 IFEVTAKYKPPIMPIGKGAYGIVCSAM-------NSETNESVAIKKIANAFDNKIDAKRT 107 ++E P+G+G +G V A + +VA+K + + +K D Sbjct: 11 LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK-DLADL 69 Query: 108 LREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA----- 160 + E+++++ + H+NI+ + + +Y+ E +L + +R+ + Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCTQE-----GPLYVIVECAAKGNLREFLRARRPPGSSE 124 Query: 161 --LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 LS YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGLAR D Sbjct: 125 GPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHID 184 Query: 219 FMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLR 274 + + R + APE L + YT DVWS G + E+ +PG Sbjct: 185 YYKKTSNGRLPVKWMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPG-------- 235 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 P EE L E + D+ P P L+ + P Sbjct: 236 -------IPVEELFSLLREGHRM--------------DRPPHCPPELYGLMRECWHAAPS 274 Query: 335 RRITVLDALA 344 +R T + Sbjct: 275 QRPTFKQLVE 284 >5X5O-A nrPDB Length = 310 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 115/279 (41%), Gaps = 51/279 (18%) Query: 70 GKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDII 129 G G++G V A ++ VA+KK+ +E ++L + H NI+ +I Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHRNIIQFYGVI 73 Query: 130 PPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYIHSA--- 183 P I E L+ I SN++ + +H + + +G+ Y+H Sbjct: 74 LEPPNYG-----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPV 128 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 243 V+HRDLK N+++ A+ LKICDFG +R + + M V T + APE++ + + Sbjct: 129 KVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEVIQSLPV-SE 186 Query: 244 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 303 D +S G + E++ R+ F G + + L++E K +P Sbjct: 187 TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE-----------------KNERLTIP 229 Query: 304 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 +S + L+ + D ++R + Sbjct: 230 SSCPRSFAE-----------LLHQCWEADAKKRPSFKQI 257 >4AN9-A nrPDB Length = 301 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 124/298 (41%), Gaps = 38/298 (12%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + E+ I +G G G+V + + +A K I + + +RE+++ Sbjct: 2 ALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-HLEIKPAIRNQIIRELQV 60 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQ 172 L + IV + ++ I E MD L Q+++ + E+ Sbjct: 61 LHECNSPYIVGFYGAF-----YSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 115 Query: 173 ILRGLKYI-HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 +++GL Y+ ++HRD+KPSN+L+N+ ++K+CDFG++ + + E+V TR Y + Sbjct: 116 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMS 174 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE L + Y+ D+WS+G +E+ + P + LL ++ P Sbjct: 175 PERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPRP---PMAIFELLDYIVNEPP------- 223 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 349 P P + +F D + K L +P R + + H ++ Sbjct: 224 -----------PKLPSAVFSLEF-------QDFVNKCLIKNPAERADLKQLMVHAFIK 263 >4UY9-A nrPDB Length = 323 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 128/342 (37%), Gaps = 58/342 (16%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLRE 110 G + E+ IG G +G V A + VA+K + D I + +E Sbjct: 1 GQLLEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQE 58 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 KL + H NI+A+R + ++ + E + S + + + + Sbjct: 59 AKLFAMLKHPNIIALRGVCLKEP-----NLCLVMEFARGGPLNRVLSGKRIPPDILVNWA 113 Query: 171 YQILRGLKYIHSAN---VLHRDLKPSNLLL--------NANCDLKICDFGLARVTSESDF 219 QI RG+ Y+H ++HRDLK SN+L+ +N LKI DFGLAR + Sbjct: 114 VQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK 173 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 M+ T + APE++ +S ++ DVWS G + EL+ + F G D + + Sbjct: 174 MSA-AGTYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAM- 230 Query: 280 IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 + +P + L+E DP R + Sbjct: 231 ----------------NKLALPIPSTCPEPFAK-----------LMEDCWNPDPHSRPSF 263 Query: 340 LDALAHPYLNSLHDISDEPECTIPFNFDF---ENHALSEEQM 378 + L + L I + +P + +N ++M Sbjct: 264 TNIL-----DQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEM 300 >5AP3-A nrPDB Length = 313 Score = 201 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 124/320 (38%), Gaps = 49/320 (15%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 N++ V + + IG G V +N E + AIK + + Sbjct: 17 NLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRN 75 Query: 110 EIKLLRHMD-H-ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ 167 EI L + H + I+ + D +Y+ E + DL+ ++ +++ + Sbjct: 76 EIAYLNKLQQHSDKIIRLYDY-----EITDQYIYMVMECGNIDLNGWLKKKKSIDPWERK 130 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTEYV 224 + +L + IH ++H DLKP+N L+ + LK+ DFG+A V Sbjct: 131 SYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQV 189 Query: 225 VTRWYRAPELLLNSSDY----------TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 T Y PE + + S + DVWS+GCI + K F ++Q+ Sbjct: 190 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQIS 247 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 L +I E+EF P P + + D+++ L DP+ Sbjct: 248 KLHAII--DPNHEIEF------------PDIPEKDLQ-----------DVLKCCLKRDPK 282 Query: 335 RRITVLDALAHPYLNSLHDI 354 +RI++ + LAHPY+ Sbjct: 283 QRISIPELLAHPYVQIQTHP 302 >4LFI-A nrPDB Length = 374 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 155/342 (45%), Gaps = 50/342 (14%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAI------------------------ 91 + K +G+G Y V + ++ + I Sbjct: 35 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 94 Query: 92 KKIANAFDNKIDAKRTLREIKLLRHMD----------HENIVAIRDIIPPPLRNAFNDVY 141 K + D T ++ +L+ + H NI+ + DII P+ Sbjct: 95 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA--- 151 Query: 142 IAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-AN 200 + +E +D +I+ L++ +++++++L+ L Y HS ++HRD+KP N++++ N Sbjct: 152 LVFEYVDNVDFRIL--YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 209 Query: 201 CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD- 259 L++ D+GLA + V +R+++ PELL++ Y ++D+WS G + ++ Sbjct: 210 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 269 Query: 260 RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE--------NAKRYIRQLPPYPRQSIT 311 R+P F G + QL +++++GT E+ E + +YIR+ P + + Sbjct: 270 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK-PWHRFINDG 328 Query: 312 DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 353 +K + + IDLI+ +L +D + R+T +A+ HP+ + + Sbjct: 329 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >1JPA-A nrPDB Length = 312 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 98/233 (42%), Gaps = 19/233 (8%) Query: 67 MPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG G +G VCS + VAIK + + + K + L E ++ DH N++ Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK-QRRDFLSEASIMGQFDHPNVI 97 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIH 181 + ++ V I E M+ L +R N + L I G+KY+ Sbjct: 98 HLEGVVTKS-----TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLA 152 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTR---WYRAPELL 235 N +HRDL N+L+N+N K+ DFGL+R + T + + + APE + Sbjct: 153 DMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI 212 Query: 236 LNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 +T+A DVWS G + E+M + + + + + + P + Sbjct: 213 -QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMD 264 >5MJB-A nrPDB Length = 305 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 109/290 (37%), Gaps = 28/290 (9%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNE---SVAIKKIANAFDNKIDAKRTLREIKL 113 E+ + IG G +G V + VAIK + + K + L E + Sbjct: 22 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK-QRRDFLSEASI 80 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLY 171 + DH NI+ + ++ V I E M+ L +R N + L Sbjct: 81 MGQFDHRNIIRLEGVVTKS-----RPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLR 135 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTR- 227 I G+KY+ N +HRDL N+L+N+N K+ DFGL+R + T + + Sbjct: 136 GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKI 195 Query: 228 --WYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPS 284 + APE + +T+A DVWS G + E+M + + + + + + P Sbjct: 196 PVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPP 254 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 + Q R + T ++KM+ +P Sbjct: 255 PMDCPAALHQLMLDCWQKDRNSRPRFAEIVNT--------LDKMI-RNPA 295 >6BXI-A nrPDB Length = 333 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 68/360 (18%), Positives = 123/360 (34%), Gaps = 78/360 (21%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANA-FDNKIDAKRTLREIKLLR 115 + + + IG+GA+G V +T A+K + A K E +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQIL 174 D +V + L ++Y+ E + D+ ++ L+EE Q+++ + + Sbjct: 62 EADSLWVVKMFYSFQDKL-----NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 116 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA---RVTSESDFMT---------- 221 + IH +HRD+KP NLLL++ +K+ DFGL + ++F Sbjct: 117 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 176 Query: 222 -----------------------EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 V T Y APE+ + + Y D WS+G I E++ Sbjct: 177 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEML 235 Query: 259 DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 P F + +M N K + P P + Sbjct: 236 IGYPPFCSETPQETYKKVM----------------NWKETLTFPPEVP----------IS 269 Query: 319 PLAIDLIEK-MLTFDPRRRITV---LDALAHPYLN--SLHDISDEPECTIPFNFDFENHA 372 A DLI + ++ RI + ++ + I + P ++ + Sbjct: 270 EKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTS 327 >5B2L-A nrPDB Length = 324 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 117/309 (37%), Gaps = 39/309 (12%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 110 I G ++ + +G G G V +T +A+K++ + NK + KR L + Sbjct: 7 IGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG-NKEENKRILMD 65 Query: 111 IKL-LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS-NQALSEEHCQY 168 + + L+ D IV DV+IA ELM T ++ + + E Sbjct: 66 LDVVLKSHDCPYIVQCFGTFITN-----TDVFIAMELMGTSAEKLKKRMQGPIPERILGK 120 Query: 169 FLYQILRGLKYI-HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR 227 I++ L Y+ V+HRD+KPSN+LL+ +K+CDFG++ +S T Sbjct: 121 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 180 Query: 228 WYRAPELLL----NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 Y APE + DY DVWS+G +EL + + Sbjct: 181 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD------------- 227 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 E + +++ PP + ++ LT D R+R L Sbjct: 228 --------FEVLTKVLQEEPP-----LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLL 274 Query: 344 AHPYLNSLH 352 H ++ Sbjct: 275 EHSFIKRYE 283 >2Y6O-A nrPDB Length = 291 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 59/231 (25%), Positives = 98/231 (42%), Gaps = 17/231 (7%) Query: 67 MPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG G +G VCS + VAIK + + +K + L E ++ DH NI+ Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-QRRDFLSEASIMGQFDHPNII 78 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIH 181 + ++ V I E M+ L +R N + L I G+KY+ Sbjct: 79 HLEGVVTKC-----KPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTEYVVTRW--YRAPELLLN 237 + +HRDL N+L+N+N K+ DFG++RV + T + APE + Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA- 192 Query: 238 SSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 +T+A DVWS G + E+M + + + ++ + E P + Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMD 243 >4CRS-A nrPDB Length = 341 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 125/337 (37%), Gaps = 52/337 (15%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL----REIKLLRHMDHENIVAIR 126 +G +G V A TNE AIK + D +L R + + + H +V + Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 127 DIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 185 V E DL I ++ SE ++ ++ GL+Y+H + Sbjct: 82 ACFQTK-----EHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKI 135 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARV-TSESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 ++RDLK NLLL+ +KI DFGL + D + + T + APE+L +S YT A Sbjct: 136 VYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS-YTRA 194 Query: 245 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 304 +D W +G + E++ + FPG D ++ + RY R L Sbjct: 195 VDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN---------------DEVRYPRFL-- 237 Query: 305 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT-----VLDALAHPYLN--SLHDISDE 357 AI ++ ++L +P RR+ D HP+ + D Sbjct: 238 -------------STEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMD- 283 Query: 358 PECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 394 + PF + EA P + Sbjct: 284 KKVKPPFIPTIRGRE-DVSNFDDEFTSEAPILTPPRE 319 >3HMP-A nrPDB Length = 342 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 122/322 (37%), Gaps = 49/322 (15%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 + V + + IG G V +N E + AIK + + Sbjct: 43 ASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSY 101 Query: 108 LREIKLLRHMD-H-ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEH 165 EI L + H + I+ + D +Y+ E + DL+ ++ +++ Sbjct: 102 RNEIAYLNKLQQHSDKIIRLYDY-----EITDQYIYMVMECGNIDLNSWLKKKKSIDPWE 156 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTE 222 + + +L + IH ++H DLKP+N L+ + LK+ DFG+A Sbjct: 157 RKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDS 215 Query: 223 YVVTRWYRAPELLLNSSDY----------TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 V T Y PE + + S + DVWS+GCI + K F ++Q Sbjct: 216 QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQ 273 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 + L +I E+EF P P + + D+++ L D Sbjct: 274 ISKLHAII--DPNHEIEF------------PDIPEKDLQ-----------DVLKCCLKRD 308 Query: 333 PRRRITVLDALAHPYLNSLHDI 354 P++RI++ + LAHPY+ Sbjct: 309 PKQRISIPELLAHPYVQIQTHP 330 >4WUA-A nrPDB Length = 401 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 82/371 (22%), Positives = 145/371 (39%), Gaps = 86/371 (23%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 +Y I +G G + V + + + + VA+K + +A + + L EI+LL+ + Sbjct: 39 FNGRYHV-IRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSA---EHYTETALDEIRLLKSV 94 Query: 118 DH--EN------IVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQ 167 + N +V + D N + + +E++ L + I + Q L + Sbjct: 95 RNSDPNDPNREMVVQLLDDFKISGVNG-THICMVFEVLGHHLLKWIIKSNYQGLPLPCVK 153 Query: 168 YFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNANCD------------------------ 202 + Q+L+GL Y+H+ ++H D+KP N+LL+ N Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSA 213 Query: 203 -------------------------LKICDFGLARVTSESDFMTEYVVTRWYRAPELLLN 237 +KI D G A + TE + TR YR+ E+L+ Sbjct: 214 VSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH--FTEDIQTRQYRSLEVLIG 271 Query: 238 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRD------HVHQLRLLMELIGTPSEEELE-- 289 S Y D+WS C+ EL LF + L++EL+G + + Sbjct: 272 SG-YNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG 330 Query: 290 ------FLNENAKRYIRQLPPYPR-QSITDKFPTVHPLA---IDLIEKMLTFDPRRRITV 339 F + ++I +L P+ + + +K+ A D + ML P +R T Sbjct: 331 KYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATA 390 Query: 340 LDALAHPYLNS 350 + L HP+LNS Sbjct: 391 AECLRHPWLNS 401 >3OMV-A nrPDB Length = 307 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 123/283 (43%), Gaps = 20/283 (7%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 +E+ A IG G++G V VA+K + + E+ +LR Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQ-ALSEEHCQYFLYQI 173 H NI+ +++ I + + L++ + + Q Sbjct: 88 KTRHVNILLFMG------YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQT 141 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRWYR 230 +G+ Y+H+ N++HRD+K +N+ L+ +KI DFGLA V S S + + + + Sbjct: 142 AQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM 201 Query: 231 APELL--LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 APE++ +++ ++ DV+S G + ELM + + ++ Q ++ + + +L Sbjct: 202 APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQ--IIFMVGRGYASPDL 259 Query: 289 EFLNENAKRYIRQLPPYPRQSITDKFPTVHP--LAIDLIEKML 329 L +N + +++L + + ++ P +I+L++ L Sbjct: 260 SKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >6GQK-A nrPDB Length = 328 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 119/319 (37%), Gaps = 60/319 (18%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSA-----MNSETNESVAIKKIANAFDNKIDAKR 106 + + +E +G GA+G V A + S+ +VA+K + + + + + Sbjct: 32 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSA-HSTEREA 90 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ------ 159 + E+K+L ++ +HENIV + Y Y DL +R + Sbjct: 91 LMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCY----GDLLNFLRRKRDEFVPY 146 Query: 160 ----------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 L+ EH F YQ+ +G+ ++ S N +HRDL N+LL KICDFG Sbjct: 147 KVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFG 206 Query: 210 LARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFP 265 LAR + R + APE + NS YT DVWS G EL +P Sbjct: 207 LARDIKNDSNYVDKGNARLPVKWMAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYP 265 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 G ++ + + R S + P D++ Sbjct: 266 GM-------------------------PVDSKFYKMIKEGFRMSSPEYAPA---EMYDIM 297 Query: 326 EKMLTFDPRRRITVLDALA 344 + DP +R T + Sbjct: 298 KTCWDADPDKRPTFKQIVQ 316 >4XI2-A nrPDB Length = 446 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 107/269 (39%), Gaps = 26/269 (9%) Query: 18 PGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIV 77 G + P +N P+T G +E+ K + +G G +G+V Sbjct: 153 SAGLISRLKYPVSKQNKNAPSTAGLGYG---------SWEIDPKDLTFLKELGTGQFGVV 203 Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 VAIK I + + + E K++ ++ HE +V + + Sbjct: 204 KYGKWRG-QYDVAIKMIR---EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ----- 254 Query: 138 NDVYIAYELM-DTDLHQIIRS-NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL 195 ++I E M + L +R + + ++Y+ S LHRDL N Sbjct: 255 RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNC 314 Query: 196 LLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGC 252 L+N +K+ DFGL+R + ++ T V +++ + PE+L+ S +++ D+W+ G Sbjct: 315 LVNDQGVVKVSDFGLSRYVLDDEY-TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGV 372 Query: 253 IFMELMD-RKPLFPGRDHVHQLRLLMELI 280 + E+ K + + + + + Sbjct: 373 LMWEIYSLGKMPYERFTNSETAEHIAQGL 401 >3TT0-A nrPDB Length = 382 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 119/318 (37%), Gaps = 65/318 (20%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-------SVAIKKIANAFDNKIDAKRTL 108 +E+ P+G+GA+G V A ++ VA+K + + K D + Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK-DLSDLI 122 Query: 109 REIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------ 160 E+++++ + H+NI+ + +Y+ E +L + +++ + Sbjct: 123 SEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPPGLEYS 177 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 LS + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGL Sbjct: 178 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 237 Query: 211 ARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 AR D+ + R + APE L + YT DVWS G + E+ +PG Sbjct: 238 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDR-IYTHQSDVWSFGVLLWEIFTLGGSPYPG 296 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 P EE + L E + DK ++ Sbjct: 297 ---------------VPVEELFKLLKEGHRM--------------DKPSNCTNELYMMMR 327 Query: 327 KMLTFDPRRRITVLDALA 344 P +R T + Sbjct: 328 DCWHAVPSQRPTFKQLVE 345 >1ZXE-A nrPDB Length = 303 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 133/321 (41%), Gaps = 56/321 (17%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 I +G+GA+G V A N+ + AIKKI + + L E+ LL ++H+ +V Sbjct: 11 IAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQYVVRY 67 Query: 126 RDIIPPPLR--------NAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYF--LYQILR 175 + ++I E + + ++ L+++ +Y+ QIL Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILE 127 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---------------SDFM 220 L YIHS ++HR+LKP N+ ++ + ++KI DFGLA+ SD + Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 T + T Y A E+L + Y ID++S+G IF E++ P G + V+ L+ L + Sbjct: 188 TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILKKLRSV- 244 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 S E ++N + +++ I ++ DP +R Sbjct: 245 ---SIEFPPDFDDNKMKVEKKI----------------------IRLLIDHDPNKRPGAR 279 Query: 341 DALAHPYLNSLHDISDEPECT 361 L +L H E Sbjct: 280 TLLNSGWLPVKHQDEVIKEAL 300 >4H1J-A nrPDB Length = 293 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 114/296 (38%), Gaps = 47/296 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + + + +G+G +G V + + +VA+K + ++ + E Sbjct: 19 YGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCT-LDNKEKFMSEAV 77 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYE-LMDTDLHQIIRSNQ-ALSEEHCQYFL 170 +++++DH +IV + II +I E +L + N+ +L + Sbjct: 78 IMKNLDHPHIVKLIGIIEEEPT------WIIMELYPYGELGHYLERNKNSLKVLTLVLYS 131 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 QI + + Y+ S N +HRD+ N+L+ + +K+ DFGL+R + D+ V TR Sbjct: 132 LQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASV-TRLPI 190 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + +PE + N +T A DVW E++ K F ++ + +L + P + Sbjct: 191 KWMSPESI-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPD 249 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 P+ L+ + +DP R + Sbjct: 250 L-----------------------------CPPVLYTLMTRCWDYDPSDRPRFTEL 276 >3V5Q-A nrPDB Length = 297 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 115/311 (36%), Gaps = 63/311 (20%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMN-----SETNESVAIKKIANAFDNKIDAKRTLREIK 112 + + +G+GA+G V A ++ VA+K + + K RE + Sbjct: 12 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQREAE 69 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA----------- 160 LL ++ HE+IV + + + + +E M DL++ +R++ Sbjct: 70 LLTNLQHEHIVKFYGVCGDG-----DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 124 Query: 161 -----LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 215 L + QI G+ Y+ S + +HRDL N L+ AN +KI DFG++R Sbjct: 125 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 184 Query: 216 ESDFMTEYVVT---RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVH 271 +D+ T + PE ++ +T DVWS G I E+ K + + Sbjct: 185 STDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 + + + + ++ D++ Sbjct: 244 VIECITQ-----------------------------GRVLERPRVCPKEVYDVMLGCWQR 274 Query: 332 DPRRRITVLDA 342 +P++R+ + + Sbjct: 275 EPQQRLNIKEI 285 >2HK5-A nrPDB Length = 270 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 114/265 (43%), Gaps = 17/265 (6%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + +E+ + +G G +G V A ++ + VA+K + + + L E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPG---SMSVEAFLAEAN 62 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQAL--SEEHCQYF 169 +++ + H+ +V + ++ +YI E M L ++S++ F Sbjct: 63 VMKTLQHDKLVKLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 116 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW- 228 QI G+ +I N +HRDL+ +N+L++A+ KI DFGLARV ++++ Sbjct: 117 SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPI 176 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE + N +T DVWS G + ME++ + +PG + +R L P E Sbjct: 177 KWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE 235 Query: 287 ELEFLNENAKRYIRQLPPYPRQSIT 311 N + P R + Sbjct: 236 NCPEELYNIMMRCWKNRPEERPTFE 260 >2JD5-A nrPDB Length = 373 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 137/331 (41%), Gaps = 45/331 (13%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 + +G G + V A + N VA+K + +K+ + EIKLL+ + Sbjct: 16 YKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRV 72 Query: 118 DHE-----------NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS--NQALSEE 164 + +I+ + D N V + +E++ +L +I+ ++ + Sbjct: 73 NDADNTKEDSMGANHILKLLDHFNHKGPNG-VHVVMVFEVLGENLLALIKKYEHRGIPLI 131 Query: 165 HCQYFLYQILRGLKYIHSA-NVLHRDLKPSNLLL------NANCDLKICDFGLARVTSES 217 + + Q+L GL Y+H ++H D+KP N+L+ +KI D G A E Sbjct: 132 YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH 191 Query: 218 DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRD------HVH 271 T + TR YR+PE+LL + + D+WS C+ EL+ LF + Sbjct: 192 --YTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDD 248 Query: 272 QLRLLMELIGTPSEEELE--------FLNENAKRYIRQLPPYPRQS-ITDKFPTVHPLAI 322 + ++EL+G L F + R I +L +P + +T+K+ A Sbjct: 249 HIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAK 308 Query: 323 ---DLIEKMLTFDPRRRITVLDALAHPYLNS 350 D + ML DPR+R + HP+L Sbjct: 309 EISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >1K9A-A nrPDB Length = 450 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 116/319 (36%), Gaps = 54/319 (16%) Query: 34 ENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKK 93 + + T++ F + + + K + IGKG +G V VA+K Sbjct: 171 KVMEGTVAAQDEFYRSG-----WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC 223 Query: 94 IANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLH 152 I N A+ L E ++ + H N+V + +I +YI E M L Sbjct: 224 IKNDAT----AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLV 275 Query: 153 QIIRSNQA--LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 +RS L + F + ++Y+ N +HRDL N+L++ + K+ DFGL Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL 335 Query: 211 ARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDH 269 + S + T + +W APE L ++ DVWS G + E+ + +P Sbjct: 336 TKEASSTQD-TGKLPVKW-TAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYP---- 388 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 P ++ + + + K D P D+++ Sbjct: 389 -----------RIPLKDVVPRVEKGYKM--------------DAPDGCPPAVYDVMKNCW 423 Query: 330 TFDPRRRITVLDA---LAH 345 D R T L L H Sbjct: 424 HLDAATRPTFLQLREQLEH 442 >2R2P-A nrPDB Length = 295 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 113/278 (40%), Gaps = 26/278 (9%) Query: 67 MPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG G +G VCS + VAIK + + K + L E ++ DH NI+ Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK-QRRDFLGEASIMGQFDHPNII 86 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIH 181 + ++ V I E M+ L ++ N + L I G+KY+ Sbjct: 87 HLEGVVTKS-----KPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLS 141 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTEYVVTRW--YRAPELLLN 237 +HRDL N+L+N+N K+ DFGL+RV + T + APE + Sbjct: 142 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA- 200 Query: 238 SSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 +T+A DVWS G + E++ + + + ++ + E PS + A Sbjct: 201 FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP-----AA 255 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 Y L + ++ + +++++K L +P Sbjct: 256 LYQLMLDCWQKERNSR---PKFDEIVNMLDK-LIRNPA 289 >4P5Q-A nrPDB Length = 361 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 61/241 (25%), Positives = 101/241 (41%), Gaps = 17/241 (7%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNS---ETNESVAIKKIANAFDNKIDAKRTLREIKL 113 E+ A +G G +G VCS + SVAIK + + K + L E + Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK-QRRDFLGEASI 87 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLY 171 + DH NI+ + ++ V I E M+ L +R + A + L Sbjct: 88 MGQFDHPNIIRLEGVVTKS-----KPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLR 142 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTEYVVTRW- 228 I G+KY+ +HRDL N+L+N+N K+ DFGL+RV + T Sbjct: 143 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 202 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + +PE + +T+A DVWS G + E+M + + + ++ + E P Sbjct: 203 RWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPM 261 Query: 287 E 287 + Sbjct: 262 D 262 >3LLT-A nrPDB Length = 360 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 133/329 (40%), Gaps = 49/329 (14%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 I +G G +G V + + + A+K + N AK E +L+ + +++I Sbjct: 38 LVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKI---EADILKKIQNDDIN 94 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIH 181 + ++ + + +E + L++II N E + + +IL+ L Y+ Sbjct: 95 NNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 182 SANVLHRDLKPSNLLLNA-------------------------NCDLKICDFGLARVTSE 216 ++ H DLKP N+LL+ + +K+ DFG A + Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF--K 212 Query: 217 SDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 SD+ + TR YRAPE++LN + + D+WS GC+ EL LF +H+ L ++ Sbjct: 213 SDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMM 271 Query: 277 MELIG-TPSEEELEFLNENAKRYIRQL---PPYPRQSITDKFPT------------VHPL 320 +I P E N +Y+ + +P + + H L Sbjct: 272 ESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHEL 331 Query: 321 AIDLIEKMLTFDPRRRITVLDALAHPYLN 349 D + +L DP R + + L H +L Sbjct: 332 FCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3DTC-A nrPDB Length = 271 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 111/288 (38%), Gaps = 50/288 (17%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAIR 126 IG G +G V A + VA+K + D I + +E KL + H NI+A+R Sbjct: 15 IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN-- 184 + ++ + E + S + + + + QI RG+ Y+H Sbjct: 73 GVCLKEP-----NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 127 Query: 185 -VLHRDLKPSNLLL--------NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELL 235 ++HRDLK SN+L+ +N LKI DFGLAR + M+ + APE++ Sbjct: 128 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWMAPEVI 186 Query: 236 LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 +S ++ DVWS G + EL+ + F G D + + Sbjct: 187 -RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAM----------------- 228 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 + +P + L+E DP R + + L Sbjct: 229 NKLALPIPSTCPEPFAK-----------LMEDCWNPDPHSRPSFTNIL 265 >5L6P-A nrPDB Length = 298 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 57/233 (24%), Positives = 96/233 (41%), Gaps = 19/233 (8%) Query: 67 MPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG G +G VC + VAIK + + + + L E ++ DH NI+ Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTER-QRRDFLSEASIMGQFDHPNII 83 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIH 181 + ++ V I E M+ L +R N + L I G+KY+ Sbjct: 84 RLEGVVTKS-----RPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTR---WYRAPELL 235 N +HRDL N+L+N+N K+ DFGL+R + T + + + APE + Sbjct: 139 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI 198 Query: 236 LNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 +T+A DVWS G + E+M + + + + + + P + Sbjct: 199 A-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMD 250 >2VWV-A nrPDB Length = 302 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 100/244 (40%), Gaps = 21/244 (8%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKL 113 E+ Y IG G +G VC + VAIK + + + + L E + Sbjct: 12 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER-QRREFLSEASI 70 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLY 171 + +H NI+ + ++ + V I E M+ L +R N + L Sbjct: 71 MGQFEHPNIIRLEGVVTNSM-----PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLR 125 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES-------DFMTEYV 224 I G++Y+ + +HRDL N+L+N+N K+ DFGL+R E+ + + Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKI 185 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTP 283 RW APE + +T+A D WS G + E+M + + + + + + P Sbjct: 186 PIRW-TAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP 243 Query: 284 SEEE 287 + Sbjct: 244 PPPD 247 >5A46-A nrPDB Length = 386 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 125/343 (36%), Gaps = 71/343 (20%) Query: 37 PATLSHGGRFIQYNIFGNI------FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE--- 87 P+ LS G + + +E+ P+G+G +G V A ++ Sbjct: 10 PSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 69 Query: 88 ----SVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYI 142 VA+K + + K D + E+++++ + H+NI+ + +Y+ Sbjct: 70 NRVTKVAVKMLKSDATEK-DLSDLISEMEMMKMIGKHKNIINLLGACTQD-----GPLYV 123 Query: 143 AYELMD-TDLHQIIRSNQA----------------LSEEHCQYFLYQILRGLKYIHSANV 185 E +L + +++ + LS + YQ+ RG++Y+ S Sbjct: 124 IVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC 183 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYT 242 +HRDL N+L+ + +KI DFGLAR D+ + R + APE L + YT Sbjct: 184 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDR-IYT 242 Query: 243 AAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 DVWS G + E+ +PG P EE + L E + Sbjct: 243 HQSDVWSFGVLLWEIFTLGGSPYPG---------------VPVEELFKLLKEGHRM---- 283 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 DK ++ P +R T + Sbjct: 284 ----------DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 316 >3QGY-A nrPDB Length = 286 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 110/273 (40%), Gaps = 24/273 (8%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 + + IG G +G+V ++ VAIK I ++ D + E +++ + Sbjct: 24 IDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDD---FIEEAEVMMKL 79 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILR 175 H +V + + + + +E M+ L +R+ + + E + Sbjct: 80 SHPKLVQLYGVCLEQA-----PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCE 134 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAP 232 G+ Y+ A V+HRDL N L+ N +K+ DFG+ R + + T T++ + +P Sbjct: 135 GMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQY-TSSTGTKFPVKWASP 193 Query: 233 ELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 E+ + S Y++ DVWS G + E+ K + R + + + S + Sbjct: 194 EV-FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI-------STGFRLYK 245 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 A ++ Q+ + + + P L L Sbjct: 246 PRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL 278 >5HI2-A nrPDB Length = 283 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 119/271 (43%), Gaps = 25/271 (9%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +E+ IG G++G V VA+K + + E+ + Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGV 64 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQ-ALSEEHCQYFLY 171 LR H NI+ P + I + + L+ + +++ + Sbjct: 65 LRKTRHVNILLFMGYSTKP------QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIAR 118 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE---SDFMTEYVVTRW 228 Q RG+ Y+H+ +++HRDLK +N+ L+ + +KI DFGLA V S S + + Sbjct: 119 QTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL 178 Query: 229 YRAPELL--LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS-E 285 + APE++ +S+ Y+ DV++ G + ELM + + ++ Q ++E++G S Sbjct: 179 WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVGRGSLS 235 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPT 316 +L + N + +++L + D+ P+ Sbjct: 236 PDLSKVRSNCPKRMKRLMAECLKKKRDERPS 266 >3GQL-A nrPDB Length = 326 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 119/318 (37%), Gaps = 65/318 (20%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-------SVAIKKIANAFDNKIDAKRTL 108 +E+ P+G+GA+G V A ++ VA+K + + K D + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK-DLSDLI 81 Query: 109 REIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------ 160 E+++++ + H+NI+ + +Y+ E +L + +++ + Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 LS + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGL Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 211 ARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 AR D+ + R + APE L + YT DVWS G + E+ +PG Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDR-IYTHQSDVWSFGVLLWEIFTLGGSPYPG 255 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 P EE + L E + DK ++ Sbjct: 256 ---------------VPVEELFKLLKEGHRM--------------DKPSNCTNELYMMMR 286 Query: 327 KMLTFDPRRRITVLDALA 344 P +R T + Sbjct: 287 DCWHAVPSQRPTFKQLVE 304 >1S9I-A nrPDB Length = 354 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 72/317 (22%), Positives = 127/317 (40%), Gaps = 28/317 (8%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + E+ I +G G G+V + + +A K I + + +RE++ Sbjct: 8 AKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLI-HLEIKPAIRNQIIRELQ 66 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLY 171 +L + IV + ++ I E MD L Q+++ + + EE Sbjct: 67 VLHECNSPYIVGFYGAF-----YSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSI 121 Query: 172 QILRGLKYIHSAN-VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYR 230 +LRGL Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ +S +V TR Y Sbjct: 122 AVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYM 180 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE L + Y+ D+WS+G +EL + P D + + E E Sbjct: 181 APERLQGT-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHS 239 Query: 291 LN----------------ENAKRYIRQLPPYPRQSITDKFPT--VHPLAIDLIEKMLTFD 332 ++ I +L Y K P P + + K L + Sbjct: 240 ISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKN 299 Query: 333 PRRRITVLDALAHPYLN 349 P R + H ++ Sbjct: 300 PAERADLKMLTNHTFIK 316 >2VD5-A nrPDB Length = 412 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 116/327 (35%), Gaps = 46/327 (14%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK-LLR 115 + + IG+GA+ V +T + A+K + K RE + +L Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQII-RSNQALSEEHCQYFLYQI 173 + D I + N +Y+ E + DL ++ + + + E +++L +I Sbjct: 117 NGDRRWITQLHFAFQDE-----NYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEI 171 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY--VVTRWYRA 231 + + +H +HRD+KP N+LL+ +++ DFG + V T Y + Sbjct: 172 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 231 Query: 232 PELLL------NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 PE+L + Y D W++G E+ + F ++ S Sbjct: 232 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSL 291 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---TVLDA 342 ++ V A D I+++L P R+ D Sbjct: 292 PLVD-------------------------EGVPEEARDFIQRLLCP-PETRLGRGGAGDF 325 Query: 343 LAHPYLNSLHDISDEPECTIPFNFDFE 369 HP+ L D + PF DFE Sbjct: 326 RTHPFFFGL-DWDGLRDSVPPFTPDFE 351 >2ZMD-A nrPDB Length = 390 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 121/322 (37%), Gaps = 49/322 (15%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 + V + + IG G V +N E + AIK + + Sbjct: 43 ASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSY 101 Query: 108 LREIKLLRHMD-H-ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEH 165 EI L + H + I+ + D +Y+ E + DL+ ++ +++ Sbjct: 102 RNEIAYLNKLQQHSDKIIRLYDY-----EITDQYIYMVMECGNIDLNSWLKKKKSIDPWE 156 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTE 222 + + +L + IH ++H DLKP+N L+ + LK+ DFG+A Sbjct: 157 RKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDS 215 Query: 223 YVVTRWYRAPELLLNSSDY----------TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 V Y PE + + S + DVWS+GCI + K F ++Q Sbjct: 216 QVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQ 273 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 + L +I E+EF P P + + D+++ L D Sbjct: 274 ISKLHAII--DPNHEIEF------------PDIPEKDLQ-----------DVLKCCLKRD 308 Query: 333 PRRRITVLDALAHPYLNSLHDI 354 P++RI++ + LAHPY+ Sbjct: 309 PKQRISIPELLAHPYVQIQTHP 330 >3DKO-A nrPDB Length = 318 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 58/231 (25%), Positives = 98/231 (42%), Gaps = 17/231 (7%) Query: 67 MPIGKGAYGIVCSAMNSETNES---VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG G +G VCS + VAIK + + K + L E ++ DH N+V Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK-QRRDFLCEASIMGQFDHPNVV 107 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIH 181 + ++ V I E M+ L +R + + L I G++Y+ Sbjct: 108 HLEGVVTRG-----KPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLA 162 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTR-WYRAPELLLN 237 +HRDL N+L+N+N K+ DFGL+RV + + T + APE + Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI-Q 221 Query: 238 SSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 +T+A DVWS G + E+M + + + ++ + E P+ + Sbjct: 222 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMD 272 >5HIE-A nrPDB Length = 302 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 119/300 (39%), Gaps = 29/300 (9%) Query: 39 TLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAF 98 + GR + +E+ IG G++G V VA+K + Sbjct: 18 RMKTLGRRDSSD----DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML---- 66 Query: 99 DNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRS 157 + E+ +LR H NI+ P + I + + L+ + Sbjct: 67 -TPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP------QLAIVTQWCEGSSLYHHLHI 119 Query: 158 -NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE 216 Q +G+ Y+H+ +++HRDLK +N+ L+ + +KI DFGLA V S Sbjct: 120 IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR 179 Query: 217 ---SDFMTEYVVTRWYRAPELL--LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 S + + + APE++ + + Y+ DV++ G + ELM + + ++ Sbjct: 180 WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD 239 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLA--IDLIEKML 329 Q ++ + +L + N + +++L + D+ P + I+L+ + L Sbjct: 240 Q--IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >2W1I-A nrPDB Length = 326 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 124/324 (38%), Gaps = 35/324 (10%) Query: 30 MPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE----T 85 +P EN+ + G F + + ++ + +GKG +G V T Sbjct: 14 IPTTENLYFQGAMGSAFEDRD----PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNT 69 Query: 86 NESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYE 145 E VA+KK+ ++ + + + REI++L+ + H+NIV + + R + E Sbjct: 70 GEVVAVKKLQHSTEEHL--RDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLK---LIME 124 Query: 146 LMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDL 203 + L ++ ++ + + QI +G++Y+ + +HRDL N+L+ + Sbjct: 125 YLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV 184 Query: 204 KICDFGLARVTSESDFMTE-----YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM 258 KI DFGL +V + + WY APE L S ++ A DVWS G + EL Sbjct: 185 KIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLTESK-FSVASDVWSFGVVLYELF 242 Query: 259 DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 M +IG + ++ + P P + + + Sbjct: 243 T-----YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMT 297 Query: 319 PLAIDLIEKMLTFDPRRRITVLDA 342 + +R + D Sbjct: 298 E--------CWNNNVNQRPSFRDL 313 >4Y93-A nrPDB Length = 446 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 47/237 (19%), Positives = 98/237 (41%), Gaps = 17/237 (7%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 +E+ K + +G G +G+V VAIK I + + + E K++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EGSMSEDEFIEEAKVMM 238 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS-NQALSEEHCQYFLYQI 173 ++ HE +V + + ++I E M + L +R + + Sbjct: 239 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 293 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YR 230 ++Y+ S LHRDL N L+N +K+ DFG+ R + ++ T +++ + Sbjct: 294 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEY-TSSTGSKFPVKWA 352 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 +PE+L+ S +++ D+W+ G + E+ K + + + + + P Sbjct: 353 SPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPH 408 >5O0Y-A nrPDB Length = 579 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 119/297 (40%), Gaps = 50/297 (16%) Query: 74 YGIVCSAMNSETNESVAIKK--IANAFDNKIDA---KRTLREIKLLRHMDHENIVAIRDI 128 + V A + VA+K + + ++ K RE ++ + +DH IV + D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 129 IPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN--V 185 + E + DL ++ ++ +SE+ + + QI+ LKY++ + Sbjct: 357 FSLDT----DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 186 LHRDLKPSNLLL---NANCDLKICDFGLARVTSESDF--------MTEYVVTRWYRAPEL 234 +H DLKP N+LL A ++KI DFGL+++ + + ++ T WY PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 235 LL---NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 + + +DVWSVG IF + + + F G + Q ++ Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ--------------DILQE 517 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 348 N K Q PP P V P A I + L + RI V PYL Sbjct: 518 NTILKATEVQFPPKP---------VVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >3IO7-A nrPDB Length = 313 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 116/300 (38%), Gaps = 31/300 (10%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE----TNESVAIKKIANAFDNKIDAKRTLR 109 N+ + ++ + +GKG +G V T E VA+KK+ ++ + + + R Sbjct: 21 NMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL--RDFER 78 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQII-RSNQALSEEHCQ 167 EI++L+ + H+NIV + + R + E + L + + + + Sbjct: 79 EIEILKSLQHDNIVKYKGVCYSAGRRNLK---LIMEYLPYGSLRDYLQKHKERIDHIKLL 135 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----- 222 + QI +G++Y+ + +HRDL N+L+ +KI DFGL +V + + Sbjct: 136 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 WY APE L S ++ A DVWS G + EL M +IG Sbjct: 196 ESPIFWY-APESLTESK-FSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGN 248 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 + ++ + P P + + + + +R + D Sbjct: 249 DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTE--------CWNNNVNQRPSFRDL 300 >2PL0-A nrPDB Length = 289 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 109/265 (41%), Gaps = 22/265 (8%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +EV + + +G G +G V + + VA+K + + L E L Sbjct: 16 DEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQG---SMSPDAFLAEANL 71 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR--SNQALSEEHCQYFL 170 ++ + H+ +V + ++ +YI E M+ L ++ S L+ Sbjct: 72 MKQLQHQRLVRLYAVVTQE------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMA 125 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-- 228 QI G+ +I N +HRDL+ +N+L++ KI DFGLAR+ ++++ Sbjct: 126 AQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK 185 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELI-----GT 282 + APE + N +T DVWS G + E++ + +PG + ++ L Sbjct: 186 WTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDN 244 Query: 283 PSEEELEFLNENAKRYIRQLPPYPR 307 EE + + K P + Sbjct: 245 CPEELYQLMRLCWKERPEDRPTFDY 269 >4AT3-A nrPDB Length = 299 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 118/281 (41%), Gaps = 35/281 (12%) Query: 67 MPIGKGAYGIVCSAMN-----SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 +G+GA+G V A + VA+K + +A DN K RE +LL ++ HE+ Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN--ARKDFHREAELLTNLQHEH 76 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-------------LSEEHCQ 167 IV + + + + +E M DL++ +R++ L++ Sbjct: 77 IVKFYGVCVEG-----DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT- 226 + QI G+ Y+ S + +HRDL N L+ N +KI DFG++R +D+ T Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 191 Query: 227 --RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLM--ELIG 281 + PE ++ +T DVWS+G + E+ K + + + + ++ Sbjct: 192 LPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQ 250 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAI 322 P E + R+ P+ R++I + LA Sbjct: 251 RPRTCPQEVYELMLGCWQRE--PHMRKNIKGIHTLLQNLAK 289 >6E4F-A nrPDB Length = 290 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 98/231 (42%), Gaps = 17/231 (7%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 +E+ K + +G G +G+V VAIK I + + + E K++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK---EGSMSEDEFIEEAKVMM 81 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS-NQALSEEHCQYFLYQI 173 ++ HE +V + + ++I E M + L +R + + Sbjct: 82 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 136 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YR 230 ++Y+ S LHRDL N L+N +K+ DFGL+R + ++ T V +++ + Sbjct: 137 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEY-TSSVGSKFPVRWS 195 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELI 280 PE+L+ S +++ D+W+ G + E+ K + + + + + Sbjct: 196 PPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 245 >4UYA-A nrPDB Length = 340 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 72/346 (20%), Positives = 119/346 (34%), Gaps = 59/346 (17%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK--IDAKRTLRE 110 G+ V + IG G +G V A + VA+K + A+ RE Sbjct: 18 GSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRRE 75 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 +L + H NI+ +R + + + E + + + + Sbjct: 76 ARLFAMLRHPNIIELRGVCLQQPH-----LCLVLEFARGGALNRALAGRRIPPHVLVNWA 130 Query: 171 YQILRGLKYIHSAN---VLHRDLKPSNLLLNA--------NCDLKICDFGLARVTSESDF 219 QI RG+ Y+H +LHRDLK SN+LL N LKI DFGLAR + Sbjct: 131 VQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK 190 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 M + APE++ SS ++ D+WS G + EL+ + + G D + + Sbjct: 191 MAT-AGAYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA-- 246 Query: 280 IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 + +P + L+++ DP R + Sbjct: 247 ---------------VNKLTLPIPSTCPEPFAK-----------LMKECWQQDPHIRPSF 280 Query: 340 LDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYRE 385 L L I +P E+ ++ K I + Sbjct: 281 ALILE-----QLTAIEGAVMTEMPQ----ESFHSMQDDWKLEIQQM 317 >4K33-A nrPDB Length = 325 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 122/318 (38%), Gaps = 65/318 (20%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-------SVAIKKIANAFDNKIDAKRTL 108 +E++ P+G+GA+G V A ++ +VA+K + + +K D + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK-DLSDLV 89 Query: 109 REIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA------ 160 E+++++ + H+NI+ + +Y+ E +L + +R+ + Sbjct: 90 SEMEMMKMIGKHKNIINLLGACTQG-----GPLYVLVEYAAKGNLREFLRARRPPGLDYS 144 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 L+ + YQ+ RG++Y+ S +HRDL N+L+ + +KI DFGL Sbjct: 145 FDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 204 Query: 211 ARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 AR D+ E R + APE L + YT DVWS G + E+ +PG Sbjct: 205 ARDVHNLDYYKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPG 263 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 P EE + L E + + I + Sbjct: 264 ---------------IPVEELFKLLKEGHRMDKPANCTHDLYMI--------------MR 294 Query: 327 KMLTFDPRRRITVLDALA 344 + P +R T + Sbjct: 295 ECWHAAPSQRPTFKQLVE 312 >3I81-A nrPDB Length = 315 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 131/343 (38%), Gaps = 63/343 (18%) Query: 51 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS-----ETNESVAIKKIANAFDNKIDAK 105 + +EV + +G+G++G+V + E VAIK + A + + Sbjct: 8 YVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR-ERI 66 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS------- 157 L E +++ + ++V + ++ + ELM DL +RS Sbjct: 67 EFLNEASVMKEFNCHHVVRLLGVVSQG-----QPTLVIMELMTRGDLKSYLRSLRPEMEN 121 Query: 158 NQALSEEHCQYFLY---QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT 214 N L+ + +I G+ Y+++ +HRDL N ++ + +KI DFG+ R Sbjct: 122 NPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 181 Query: 215 SESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDH 269 E+D+ + RW +PE L + +T DVWS G + E+ + + G + Sbjct: 182 YETDYYRKGGKGLLPVRW-MSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSN 239 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 LR +ME + DK + +L+ Sbjct: 240 EQVLRFVME-----------------------------GGLLDKPDNCPDMLFELMRMCW 270 Query: 330 TFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHA 372 ++P+ R + L+ ++S+ + + + F + EN Sbjct: 271 QYNPKMRPSFLEI-----ISSIKEEMEPGFREVSFYYSEENKM 308 >1BYG-A nrPDB Length = 278 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 113/311 (36%), Gaps = 49/311 (15%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 G Q + + + + K + IGKG +G V VA+K I N Sbjct: 2 GGSVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT-- 57 Query: 102 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA 160 A+ L E ++ + H N+V + +I +YI E M L +RS Sbjct: 58 --AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGR 111 Query: 161 --LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 L + F + ++Y+ N +HRDL N+L++ + K+ DFGL + S + Sbjct: 112 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 171 Query: 219 FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLM 277 T + +W APE L ++ DVWS G + E+ + +P Sbjct: 172 D-TGKLPVKW-TAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYP------------ 216 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 P ++ + + + K D P ++++ D R Sbjct: 217 ---RIPLKDVVPRVEKGYKM--------------DAPDGCPPAVYEVMKNCWHLDAAMRP 259 Query: 338 TVLDA---LAH 345 + L L H Sbjct: 260 SFLQLREQLEH 270 >3CJF-A nrPDB Length = 309 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 118/316 (37%), Gaps = 57/316 (18%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSA----MNS-ETNESVAIKKIANAFDNKIDAKRT 107 + +E P+G+GA+G V A ++ T +VA+K + + + + Sbjct: 19 ASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHS-EHRAL 77 Query: 108 LREIKLLRHMDHE-NIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ------ 159 + E+K+L H+ H N+V + P + + E +L +RS + Sbjct: 78 MSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPY 133 Query: 160 ------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 L+ EH + +Q+ +G++++ S +HRDL N+LL+ +KICDFGLAR Sbjct: 134 KDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD 193 Query: 214 TSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDH 269 + R + APE + + YT DVWS G + E+ +PG Sbjct: 194 IYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKI 252 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 + ++ + P + Sbjct: 253 DEEFCRRLKEGTRMRAPDY----------------------------TTPEMYQTMLDCW 284 Query: 330 TFDPRRRITVLDALAH 345 +P +R T + + H Sbjct: 285 HGEPSQRPTFSELVEH 300 >4PDO-A nrPDB Length = 299 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 60/233 (25%), Positives = 100/233 (42%), Gaps = 20/233 (8%) Query: 67 MPIGKGAYGIVCSAMNS----ETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 IG G +G V M + VAIK + + K L E ++ H NI Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK-QRVDFLGEAGIMGQFSHHNI 98 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYI 180 + + +I + + I E M+ L + +R S L I G+KY+ Sbjct: 99 IRLEGVIS-----KYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-----EYVVTRWYRAPELL 235 + N +HRDL N+L+N+N K+ DFGL+RV + T + RW APE + Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPEAI 212 Query: 236 LNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 + +T+A DVWS G + E+M + + + ++ + + P+ + Sbjct: 213 -SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMD 264 >2PSQ-A nrPDB Length = 370 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 120/318 (37%), Gaps = 65/318 (20%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSA----MNSETNES---VAIKKIANAFDNKIDAKRTL 108 +E P+G+G +G V A ++ + + VA+K + + K D + Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK-DLSDLV 134 Query: 109 REIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------ 160 E+++++ + H+NI+ + +Y+ E +L + +R+ + Sbjct: 135 SEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 ++ + YQ+ RG++Y+ S +HRDL N+L+ N +KI DFGL Sbjct: 190 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 249 Query: 211 ARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 AR + D+ + R + APE L + YT DVWS G + E+ +PG Sbjct: 250 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG 308 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 P EE + L E + DK ++ Sbjct: 309 ---------------IPVEELFKLLKEGHRM--------------DKPANCTNELYMMMR 339 Query: 327 KMLTFDPRRRITVLDALA 344 P +R T + Sbjct: 340 DCWHAVPSQRPTFKQLVE 357 >3QUP-A nrPDB Length = 323 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 109/296 (36%), Gaps = 45/296 (15%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETN---ESVAIKKIANAFDNKIDAKRTLREIKLL 114 + + +GKG +G V A + + VA+K + D + LRE + Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDV-YIAYELMD-TDLHQIIRSNQ------ALSEEHC 166 + DH ++ + + + + M DLH + +++ L + Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT 226 F+ I G++Y+ S N +HRDL N +L + + + DFGL+R D+ + + Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 227 RW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGT 282 + + A E L ++ YT DVW+ G E+M + + G ++ L+ Sbjct: 200 KLPVKWLALESLADN-LYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 258 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 P DL+ + + DP++R + Sbjct: 259 KQP-----------------------------PECMEEVYDLMYQCWSADPKQRPS 285 >5U6B-A nrPDB Length = 307 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 116/300 (38%), Gaps = 45/300 (15%) Query: 60 AKYKPPI-MPIGKGAYGIVCSAMNSETN--ESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++K + +G+G +G V ++ + VA+K + A + + + L E ++ Sbjct: 21 DRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKE 80 Query: 117 MDHENIVAIRDII-PPPLRNAFNDVYIAYELMD-TDLHQII------RSNQALSEEHCQY 168 DH N++ + + R +F + M DLH + L + Sbjct: 81 FDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVK 140 Query: 169 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 F+ I G++Y+ + +HRDL N +LN N + + DFGL++ D+ + + + Sbjct: 141 FMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKM 200 Query: 229 ---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPS 284 + A E L + YT+ DVWS G E+ + +PG ++ Sbjct: 201 PVKWIAIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN--------------- 244 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 E ++L + + + P + L+ + +P+ R + + Sbjct: 245 SEIYDYLRQGNR---LKQPADCLDGLYA-----------LMSRCWELNPQDRPSFTELRE 290 >4M7I-A nrPDB Length = 299 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 123/289 (42%), Gaps = 34/289 (11%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 PI +G+G +G+V A N + + AIK+I + ++ ++ +RE+K L ++H Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPG 64 Query: 122 IVAIRDIIPPPLRNAF-------NDVYIAYELMDTD-LHQIIRSNQALSEEH---CQYFL 170 IV + +YI +L + L + + E C + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD------------ 218 QI ++++HS ++HRDLKPSN+ + +K+ DFGL + + Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 219 -FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 T V T+ Y +PE + +S Y+ +D++S+G I EL+ +P + ++R L Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL-----YPFSTQMERVRTLT 238 Query: 278 EL--IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 ++ + P ++ E L P P + + + DL Sbjct: 239 DVRNLKFPPLFTQKYPCEYVM-VQDMLSPSPMERPEAINIIENAVFEDL 286 >2A1A-B nrPDB Length = 284 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 114/297 (38%), Gaps = 55/297 (18%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHEN 121 I IG G +G V A + ++ IK++ K + ++ RE+K L +DH N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRV------KYNNEKAEREVKALAKLDHVN 65 Query: 122 IVAIRDII-----------PPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA--LSEEHCQ 167 IV R+ ++I E D L Q I + L + Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR 227 QI +G+ YIHS +++RDLKPSN+ L +KI DFGL T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTL 185 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 Y +PE + +S DY +D++++G I EL+ + + E Sbjct: 186 RYMSPEQI-SSQDYGKEVDLYALGLILAELL--------------------HVCDTAFET 224 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 +F + I + ++ L++K+L+ P R + L Sbjct: 225 SKFFTDLRDGIISDIFDKKEKT--------------LLQKLLSKKPEDRPNTSEILR 267 >5KMM-A nrPDB Length = 329 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 118/319 (36%), Gaps = 60/319 (18%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNS-----ETNESVAIKKIANAFDNKI 102 QY + + + +G+GA+G V A + VA+K + A ++ Sbjct: 22 QYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA--SES 79 Query: 103 DAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA- 160 + RE +LL + H++IV + + + +E M DL++ +RS+ Sbjct: 80 ARQDFQREAELLTMLQHQHIVRFFGVCTEG-----RPLLMVFEYMRHGDLNRFLRSHGPD 134 Query: 161 --------------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKIC 206 L Q+ G+ Y+ + +HRDL N L+ +KI Sbjct: 135 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG 194 Query: 207 DFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL 263 DFG++R +D+ T + PE +L +T DVWS G + E+ Sbjct: 195 DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFT---- 249 Query: 264 FPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 G+ +QL + E ++ + + + + P P Sbjct: 250 -YGKQPWYQLS---------NTEAIDCITQGRELERPRACP--------------PEVYA 285 Query: 324 LIEKMLTFDPRRRITVLDA 342 ++ +P++R ++ D Sbjct: 286 IMRGCWQREPQQRHSIKDV 304 >1AD5-A nrPDB Length = 438 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 111/263 (42%), Gaps = 23/263 (8%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + +E+ + +G G +G V A ++ + VA+K + + + L E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPG---SMSVEAFLAEAN 229 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQAL--SEEHCQYF 169 +++ + H+ +V + ++ +YI E M L ++S++ F Sbjct: 230 VMKTLQHDKLVKLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 283 Query: 170 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 229 QI G+ +I N +HRDL+ +N+L++A+ KI DFGLAR + +W Sbjct: 284 SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-------VGAKFPIKW- 335 Query: 230 RAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEEL 288 APE + N +T DVWS G + ME++ + +PG + +R L P E Sbjct: 336 TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENC 394 Query: 289 EFLNENAKRYIRQLPPYPRQSIT 311 N + P R + Sbjct: 395 PEELYNIMMRCWKNRPEERPTFE 417 >3BGP-A nrPDB Length = 333 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 117/301 (38%), Gaps = 47/301 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI----DAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + R E+ LL+ + + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 124 IRLLDWFERP--DSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQVLEAVRHCHN 180 Query: 183 ANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 181 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 239 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 + VWS+G + +++ F + + + ++ Sbjct: 240 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------------- 277 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 V LI L P R T + HP++ + + E Sbjct: 278 --------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIH 323 Query: 362 I 362 + Sbjct: 324 L 324 >4XUF-A nrPDB Length = 297 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 119/317 (37%), Gaps = 69/317 (21%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMN---SETNE--SVAIKKIANAFDNKIDAKRTLRE 110 +E + +G GA+G V +A S+T VA+K + D+ + + + E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMSE 62 Query: 111 IKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ-ALSEEHCQ 167 +K++ + HENIV + +Y+ +E DL +RS + SE+ + Sbjct: 63 LKMMTQLGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIE 117 Query: 168 Y----------------------FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 Y F YQ+ +G++++ + +HRDL N+L+ +KI Sbjct: 118 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 177 Query: 206 CDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RK 261 CDFGLAR R + APE L YT DVWS G + E+ Sbjct: 178 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGV 236 Query: 262 PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLA 321 +PG P + L +N + + I Sbjct: 237 NPYPG---------------IPVDANFYKLIQNGFKMDQPFYATEEIYI----------- 270 Query: 322 IDLIEKMLTFDPRRRIT 338 +++ FD R+R + Sbjct: 271 --IMQSCWAFDSRKRPS 285 >2OGV-A nrPDB Length = 317 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 106/313 (33%), Gaps = 58/313 (18%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES-----VAIKKIANAFDNKIDAKR 106 + +E +G GA+G V A + VA+K + + + + Sbjct: 29 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEA 87 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN------ 158 + E+K++ H+ HENIV + V + E DL +R Sbjct: 88 LMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKAEADLD 142 Query: 159 ----QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT 214 + L +F Q+ +G+ ++ S N +HRD+ N+LL KI DFGLAR Sbjct: 143 KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 202 Query: 215 SESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDH 269 + +W APE + + YT DVWS G + E+ +PG Sbjct: 203 MNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGI-- 258 Query: 270 VHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKML 329 +F Y P + ++I ++ Sbjct: 259 ---------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------MQACW 292 Query: 330 TFDPRRRITVLDA 342 +P R T Sbjct: 293 ALEPTHRPTFQQI 305 >5TUR-A nrPDB Length = 404 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 117/301 (38%), Gaps = 47/301 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI----DAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + R E+ LL+ + + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 195 IRLLDWFERP--DSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQVLEAVRHCHN 251 Query: 183 ANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 252 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 310 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 + VWS+G + +++ F + + + ++ Sbjct: 311 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------------- 348 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 V LI L P R T + HP++ + + E Sbjct: 349 --------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIH 394 Query: 362 I 362 + Sbjct: 395 L 395 >3SXS-A nrPDB Length = 268 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 108/294 (36%), Gaps = 46/294 (15%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR 115 E+ + + +G G +G+V VA+K I + + +E + + Sbjct: 3 MELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK---EGSMSEDEFFQEAQTMM 58 Query: 116 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN-QALSEEHCQYFLYQI 173 + H +V + +YI E + + L +RS+ + L Y + Sbjct: 59 KLSHPKLVKFYGVCSKEY-----PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 113 Query: 174 LRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YR 230 G+ ++ S +HRDL N L++ + +K+ DFG+ R + +++ V T++ + Sbjct: 114 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWS 172 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 APE+ + Y++ DVW+ G + E+ K + + E + Sbjct: 173 APEV-FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTN---------------SEVVL 216 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 +++ + Y L ++ P +R T L Sbjct: 217 KVSQGHRLYRPHL--------------ASDTIYQIMYSCWHELPEKRPTFQQLL 256 >3ORP-A nrPDB Length = 311 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 117/275 (42%), Gaps = 12/275 (4%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRH 116 ++ +Y+ +G G V A + + VA+K + + + R RE + Sbjct: 10 LSDRYELG-EILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILR 175 ++H IVA+ D YI E +D L I+ + ++ + + + Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY----VVTRWYRA 231 L + H ++HRD+KP+N++++A +K+ DFG+AR ++S + T Y + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE S A DV+S+GC+ E++ +P F G V + P E L Sbjct: 188 PEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGL 246 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 + + + + ++ +++ T + DL+ Sbjct: 247 SADLDAVVLKALA---KNPENRYQTAAEMRADLVR 278 >4HVI-A nrPDB Length = 314 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 118/296 (39%), Gaps = 32/296 (10%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE----TNESVAIKKIANAFDNKIDAKRTLR 109 + ++ I +GKG +G V T VA+K++ ++ ++ + R Sbjct: 3 DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQR 60 Query: 110 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ-ALSEEHCQ 167 EI++L+ + + IV R + P R + + E + L ++ ++ L Sbjct: 61 EIQILKALHSDFIVKYRGVSYGPGRQSLR---LVMEYLPSGCLRDFLQRHRARLDASRLL 117 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMT----E 222 + QI +G++Y+ S +HRDL N+L+ + +KI DFGLA++ + D+ Sbjct: 118 LYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPG 177 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 WY APE L ++ ++ DVWS G + EL + ++G+ Sbjct: 178 QSPIFWY-APESLSDN-IFSRQSDVWSFGVVLYELFTYC-----DKSCSPSAEFLRMMGS 230 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 + ++LP P +L++ P+ R + Sbjct: 231 ERDVPALSRLLELLEEGQRLPA---------PPACPAEVHELMKLCWAPSPQDRPS 277 >5HVK-A nrPDB Length = 315 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 52/302 (17%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +GKG +G + ET E + +K++ + + L+E+K++R ++H N++ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLKEVKVMRCLEHPNVLKFI 77 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANV 185 ++ R F YI L II+S + F I G+ Y+HS N+ Sbjct: 78 GVLYKDKRLNFITEYI----KGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 133 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVT---------------SESDFMTEYVVTRWYR 230 +HR+L N L+ N ++ + DFGLAR+ + V ++ Sbjct: 134 IHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWM 193 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ N Y +DV+S G + E++ GR + L ++F Sbjct: 194 APEMI-NGRSYDEKVDVFSFGIVLCEII-------GRVNADPDYL---------PRTMDF 236 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 R PP F + DL DP +R + + L H +L + Sbjct: 237 GLNVRGFLDRYCPPNC----PPSFFPITVRCCDL-------DPEKRPSFVK-LEH-WLET 283 Query: 351 LH 352 L Sbjct: 284 LR 285 >6FEX-A nrPDB Length = 321 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 61/330 (18%), Positives = 116/330 (35%), Gaps = 68/330 (20%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSA--------------MNSETNE--SVAIKKIANAFDN 100 + +G+G +G V +N VA+K + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT- 70 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ 159 K L+E+K++ + NI+ + + + + + + M+ DL+Q + ++Q Sbjct: 71 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFLSAHQ 125 Query: 160 -------------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKIC 206 +S + QI G++Y+ + N +HRDL N L+ N +KI Sbjct: 126 LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 185 Query: 207 DFGLARVTSESDFMTEY----VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFME--LMDR 260 DFG++R D+ + RW +L+ +T A DVW+ G E ++ R Sbjct: 186 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCR 243 Query: 261 KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPL 320 F + E EF + ++ PP Q + + Sbjct: 244 AQPFGQLTDEQVI-----------ENAGEFFRDQGRQVYLSRPPACPQGLYE-------- 284 Query: 321 AIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L+ + + + +R H +L Sbjct: 285 ---LMLRCWSRESEQRPPFSQL--HRFLAE 309 >5EG3-A nrPDB Length = 334 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 120/318 (37%), Gaps = 65/318 (20%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSA----MNSETNES---VAIKKIANAFDNKIDAKRTL 108 +E P+G+GA+G V A ++ + + VA+K + + K D + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK-DLSDLV 88 Query: 109 REIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------ 160 E+++++ + H+NI+ + +Y+ +L + +R+ + Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVAYASKGNLREYLRARRPPGMELS 143 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 ++ + YQ+ RG++Y+ S +HRDL N+L+ N +KI DFGL Sbjct: 144 PDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 203 Query: 211 ARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 AR + DF E R + APE L + YT DVWS G + E+ +PG Sbjct: 204 ARDINNIDFFKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG 262 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 P EE + L E + DK ++ Sbjct: 263 ---------------IPVEELFKLLKEGHRM--------------DKPANCTNELYMMMR 293 Query: 327 KMLTFDPRRRITVLDALA 344 P +R T + Sbjct: 294 DCWHAVPSQRPTFKQLVE 311 >4RC3-A nrPDB Length = 289 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 117/301 (38%), Gaps = 47/301 (15%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI----DAKRTLREIKLLRHMDH--ENI 122 +G G +G V S + N VAIK + + + R E+ LL+ + + Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 182 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 80 IRLLDWFERP--DSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQVLEAVRHCHN 136 Query: 183 ANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 VLHRD+K N+L++ +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 137 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 195 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 + VWS+G + +++ F + + + ++ Sbjct: 196 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------------- 233 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECT 361 V LI L P R T + HP++ + + E Sbjct: 234 --------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIH 279 Query: 362 I 362 + Sbjct: 280 L 280 >5X02-A nrPDB Length = 347 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 124/328 (37%), Gaps = 72/328 (21%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMN---SETNE--SVAIKKIANAFD 99 R +Y++ +E + +G GA+G V +A S+T VA+K + D Sbjct: 35 REYEYDL---KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKAD 91 Query: 100 NKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS 157 + + + + E+K++ + HENIV + +Y+ +E DL +RS Sbjct: 92 SS-EREALMSELKMMTQLGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRS 145 Query: 158 NQ-ALSEEHCQY----------------------FLYQILRGLKYIHSANVLHRDLKPSN 194 + SE+ +Y F YQ+ +G++++ + +HRDL N Sbjct: 146 KREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARN 205 Query: 195 LLLNANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVG 251 +L+ +KICDFGLAR R + APE L YT DVWS G Sbjct: 206 VLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYG 264 Query: 252 CIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSI 310 + E+ +PG P + L +N + + I Sbjct: 265 ILLWEIFSLGVNPYPG---------------IPVDANFYKLIQNGFKMDQPFYATEEIYI 309 Query: 311 TDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 +++ FD R+R + Sbjct: 310 -------------IMQSCWAFDSRKRPS 324 >3KRL-A nrPDB Length = 335 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 107/319 (33%), Gaps = 64/319 (20%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES-----VAIKKIANAFDNKIDAKR 106 + +E +G GA+G V A + VA+K + + + + Sbjct: 37 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEA 95 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA---- 160 + E+K++ H+ HENIV + V + E DL +R + Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKRPPGLE 150 Query: 161 ------------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDF 208 LS +F Q+ +G+ ++ S N +HRD+ N+LL KI DF Sbjct: 151 YSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDF 210 Query: 209 GLARVTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPL 263 GLAR + +W APE + + YT DVWS G + E+ Sbjct: 211 GLARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNP 268 Query: 264 FPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 +PG +F Y P + ++I Sbjct: 269 YPGI-----------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI---------- 301 Query: 324 LIEKMLTFDPRRRITVLDA 342 ++ +P R T Sbjct: 302 -MQACWALEPTHRPTFQQI 319 >3KUL-B nrPDB Length = 325 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 102/265 (38%), Gaps = 21/265 (7%) Query: 31 PGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES-- 88 P P T GR + E+ A IG G G VC + Sbjct: 23 PQFYAEPHTYEEPGRAGRSFTR----EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDV 78 Query: 89 -VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM 147 VAIK + + + + L E ++ DH NI+ + ++ I E M Sbjct: 79 PVAIKALKAGYTER-QRRDFLSEASIMGQFDHPNIIRLEGVVTRG-----RLAMIVTEYM 132 Query: 148 D-TDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 + L +R++ + L + G++Y+ +HRDL N+L+++N K+ Sbjct: 133 ENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKV 192 Query: 206 CDFGLARVTSES---DFMTEYVVTR-WYRAPELLLNSSDYTAAIDVWSVGCIFME-LMDR 260 DFGL+RV + + T + APE + +++A DVWS G + E L Sbjct: 193 SDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSASDVWSFGVVMWEVLAYG 251 Query: 261 KPLFPGRDHVHQLRLLMELIGTPSE 285 + + + + + E P+ Sbjct: 252 ERPYWNMTNRDVISSVEEGYRLPAP 276 >5TOS-A nrPDB Length = 395 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 132/333 (39%), Gaps = 41/333 (12%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE---------TNESVAIKKIANAFDN 100 + N ++ + P IG+G +G V E T +A+KK+ + Sbjct: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EG 111 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN- 158 + L EI L + H N+V + + YE M L + Sbjct: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHLFRRG 166 Query: 159 ---QALSEEHCQYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLNANCDLKICDFGLARV 213 + L +GL ++HS V++RD+K SN+LL+A+ + K+ DFGLAR Sbjct: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 Query: 214 --TSESDFMTEYV-VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHV 270 + +++ V T Y APE + +S A DV+S G + +E++ K DH Sbjct: 227 GPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK---RALDHN 282 Query: 271 HQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 + + + +L K + Q + ++ + +A+ + L+ Sbjct: 283 RPAKEENLV-----DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLS 333 Query: 331 FDPRRRITVLDALAHPYLNSLHDISDEPECTIP 363 F+P+ R T+ + L L D +P T P Sbjct: 334 FEPKSRPTMDQVVR--ALQQLQDNLGKPSQTNP 364 >5UIU-A nrPDB Length = 323 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 117/289 (40%), Gaps = 36/289 (12%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAI 125 +G+G +G+V + T +VA+KK+A D + ++ +EIK++ HEN+V + Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 126 RDIIPPPLRNAFNDVYIAYELM-DTDLHQII---RSNQALSEEHCQYFLYQILRGLKYIH 181 + +D+ + Y M + L + LS G+ ++H Sbjct: 112 LGF-----SSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLH 166 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTS---ESDFMTEYVVTRWYRAPELLLNS 238 + +HRD+K +N+LL+ KI DFGLAR + ++ + V T Y APE L Sbjct: 167 ENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL--R 224 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 + T D++S G + +E++ P L + E I + +++++ Sbjct: 225 GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDK----- 279 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL---DALA 344 ++ S+ + + L +R + L Sbjct: 280 --KMNDADSTSVEAMYSVAS--------QCLHEKKNKRPDIKKVQQLLQ 318 >3BEA-A nrPDB Length = 333 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 107/317 (33%), Gaps = 62/317 (19%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES-----VAIKKIANAFDNKIDAKR 106 + +E +G GA+G V A + VA+K + + + + Sbjct: 37 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEA 95 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRS------- 157 + E+K++ H+ HENIV + V + E DL +R Sbjct: 96 LMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKSRVLET 150 Query: 158 -------NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 N LS +F Q+ +G+ ++ S N +HRD+ N+LL KI DFGL Sbjct: 151 DPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 210 Query: 211 ARVTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFP 265 AR + +W APE + + YT DVWS G + E+ +P Sbjct: 211 ARDIMNDSNYIVKGNARLPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYP 268 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 G +F Y P + ++I + Sbjct: 269 GI-----------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------M 300 Query: 326 EKMLTFDPRRRITVLDA 342 + +P R T Sbjct: 301 QACWALEPTHRPTFQQI 317 >3UIU-A nrPDB Length = 306 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 118/319 (36%), Gaps = 71/319 (22%) Query: 56 FEVTAKY---KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 + V ++ I IG G +G V A + ++ I+++ K + ++ RE+K Sbjct: 4 YTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRV------KYNNEKAEREVK 57 Query: 113 LLRHMDHENIVAIRDII------------------------PPPLRNAFNDVYIAYELMD 148 L +DH NIV R+ ++I E D Sbjct: 58 ALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCD 117 Query: 149 -TDLHQIIRSNQA--LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 L Q I + L + QI +G+ YIHS ++HRDLKPSN+ L +KI Sbjct: 118 KGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKI 177 Query: 206 CDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 DFGL T T Y +PE + +S DY +D++++G I EL+ Sbjct: 178 GDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL------- 229 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 + + E +F + I + ++ L+ Sbjct: 230 -------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT--------------LL 262 Query: 326 EKMLTFDPRRRITVLDALA 344 +K+L+ P R + L Sbjct: 263 QKLLSKKPEDRPNTSEILR 281 >3BBT-B nrPDB Length = 328 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 69/343 (20%), Positives = 128/343 (37%), Gaps = 40/343 (11%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTL 108 + + + +G GA+G V + E+V AIK + K + + + Sbjct: 7 AQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FM 65 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ-ALSEEHC 166 E ++ MDH ++V + + P + + +LM L + + ++ + + Sbjct: 66 DEALIMASMDHPHLVRLLGVCLSPT------IQLVTQLMPHGCLLEYVHEHKDNIGSQLL 119 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT 226 + QI +G+ Y+ ++HRDL N+L+ + +KI DFGLAR+ + Sbjct: 120 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGG 179 Query: 227 RW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGT 282 + + A E + + +T DVWS G ELM + G LL + Sbjct: 180 KMPIKWMALECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL 238 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 P + + D P LA + +M DP+R + + Sbjct: 239 PQPPICTID-------VYMVMVKCWMIDADSRPKFKELAAEF-SRM-ARDPQRYLVI--- 286 Query: 343 LAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYRE 385 D P P + F + L EE +++++ E Sbjct: 287 -------QGDDRMKLPS---PNDSKFFQNLLDEEDLEDMMDAE 319 >2OZO-A nrPDB Length = 613 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 59/331 (17%), Positives = 115/331 (34%), Gaps = 38/331 (11%) Query: 10 ADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPI 69 +D E P P + S +F + + Sbjct: 289 SDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLK----RDNLLIADIEL 344 Query: 70 GKGAYGIVCSAMNSETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 G G +G V + + VAIK + K D + +RE +++ +D+ IV + Sbjct: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQG-TEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 128 IIPPPLRNAFNDVYIAYELMDTD-LHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSANV 185 + + + E+ LH+ + + + + L+Q+ G+KY+ N Sbjct: 404 VCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 Query: 186 LHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRW---YRAPELLLNSSDY 241 +HR+L N+LL KI DFGL++ + + T +W + APE + N + Sbjct: 458 VHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 516 Query: 242 TAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 ++ DVWS G E + + + + + + Sbjct: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--------------KRMECPP 562 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLI---EKM 328 + PP ++D + D + ++M Sbjct: 563 ECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 >1U59-A nrPDB Length = 287 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 105/273 (38%), Gaps = 34/273 (12%) Query: 68 PIGKGAYGIVCSAMNSETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 +G G +G V + + VAIK + K D + +RE +++ +D+ IV + Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG-TEKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTD-LHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSA 183 + + + E+ LH+ + + + + L+Q+ G+KY+ Sbjct: 76 IGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRW---YRAPELLLNSS 239 N +HRDL N+LL KI DFGL++ + + T +W + APE + N Sbjct: 130 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 188 Query: 240 DYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 +++ DVWS G E + + + + + + Sbjct: 189 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--------------KRMEC 234 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLI---EKM 328 + PP ++D + D + ++M Sbjct: 235 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 267 >6BSD-A nrPDB Length = 876 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 61/336 (18%), Positives = 116/336 (34%), Gaps = 74/336 (22%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSA--------------MNSETNE--SVAIKKIANAFDN 100 + +G+G +G V +N VA+K + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT- 625 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ 159 K L+E+K++ + NI+ + + + + + + M+ DL+Q + ++Q Sbjct: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFLSAHQ 680 Query: 160 -------------------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 +S + QI G++Y+ + N +HRDL N L+ N Sbjct: 681 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 740 Query: 201 CDLKICDFGLARVTSESDFMTEY----VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFME 256 +KI DFG++R D+ + RW +L+ +T A DVW+ G E Sbjct: 741 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWE 798 Query: 257 --LMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKF 314 ++ R F + E EF + ++ PP Q + + Sbjct: 799 VLMLCRAQPFGQLTDEQVI-----------ENAGEFFRDQGRQVYLSRPPACPQGLYE-- 845 Query: 315 PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 L+ + + + +R H +L Sbjct: 846 ---------LMLRCWSRESEQRPPFSQL--HRFLAE 870 >4TPT-A nrPDB Length = 303 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 47/214 (21%), Positives = 88/214 (41%), Gaps = 28/214 (13%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +GKG +G + T + + +K++ + K L E+K++R +DH N++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTFLTEVKVMRSLDHPNVLKFI 63 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 ++ + YI L +RS + F I G+ Y+HS ++ Sbjct: 64 GVLYKDKKLNLLTEYIE----GGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCII 119 Query: 187 HRDLKPSNLLLNANCDLKICDFGLARVT---------------------SESDFMTEYVV 225 HRDL N L+ + + + DFGL+R+ ++ V Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD 259 ++ APE+L N Y +D++S G + E++ Sbjct: 180 NPYWMAPEML-NGKSYDETVDIFSFGIVLCEIIG 212 >1LUF-A nrPDB Length = 343 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 101/289 (34%), Gaps = 43/289 (14%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRTLREI 111 E + IG+GA+G V A E VA+K + + A RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREA 101 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN------------ 158 L+ D+ NIV + + + + +E M DL++ +RS Sbjct: 102 ALMAEFDNPNIVKLLGVCAVG-----KPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSD 156 Query: 159 ------------QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKIC 206 LS Q+ G+ Y+ +HRDL N L+ N +KI Sbjct: 157 LSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIA 216 Query: 207 DFGLARVTSESDFMT----EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RK 261 DFGL+R +D+ + + RW PE + + YT DVW+ G + E+ Sbjct: 217 DFGLSRNIYSADYYKADGNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYGL 274 Query: 262 PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSI 310 + G H + + + E N R P R S Sbjct: 275 QPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >5WNL-A nrPDB Length = 342 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 116/283 (40%), Gaps = 36/283 (12%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 126 +G G +G V + +AIK + + + L E K + I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 127 DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN-- 184 I P V + E M+T + + +++ L + +++ G+ ++H + Sbjct: 86 GICQEP-------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPP 138 Query: 185 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESD----FMTEYVVTRWYRAPELLLNSSD 240 +LH +LKP+N+LL+A+ +KI DFGLA+ S M T Y PE + S Sbjct: 139 LLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSR 198 Query: 241 -YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 + DV+S + ++ +K F D + L ++M+++ K + Sbjct: 199 LFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVV---------------KGHR 241 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 +LPP R P I L+++ DP+ R T + Sbjct: 242 PELPPICRPR-----PRACASLIGLMQRCWHADPQVRPTFQEI 279 >4R7H-A nrPDB Length = 343 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 107/326 (32%), Gaps = 71/326 (21%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES-----VAIKKIANAFDNKIDAKR 106 + +E +G GA+G V A + VA+K + + + + Sbjct: 41 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEA 99 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN------ 158 + E+K++ H+ HENIV + V + E DL +R Sbjct: 100 LMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCTYGDLLNFLRRKAEAMLG 154 Query: 159 -----------------QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC 201 + L +F Q+ +G+ ++ S N +HRD+ N+LL Sbjct: 155 PSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH 214 Query: 202 DLKICDFGLARVTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMEL 257 KI DFGLAR + +W APE + +S YT DVWS G + E+ Sbjct: 215 VAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDSV-YTVQSDVWSYGILLWEI 272 Query: 258 MD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPT 316 +PG +F Y P + ++I Sbjct: 273 FSLGLNPYPGI-----------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI--- 312 Query: 317 VHPLAIDLIEKMLTFDPRRRITVLDA 342 ++ +P R T Sbjct: 313 --------MQACWALEPTHRPTFQQI 330 >4YFF-A nrPDB Length = 311 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 50/203 (24%), Positives = 89/203 (43%), Gaps = 13/203 (6%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 IG G++G V N+ VAIK+ N + +K D RE+ +L ++H ++ Sbjct: 50 IGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVG 107 Query: 128 II-PPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHS--A 183 P + A YI+ L ++ + L + + +G++Y+H+ Sbjct: 108 ACLNDPSQFAIVTQYIS----GGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 163 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELLLNSSDY 241 ++HRDL N+LL + + DFG +R + D MT+ + APE+ + Y Sbjct: 164 PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRY 223 Query: 242 TAAIDVWSVGCIFMELMDRKPLF 264 T DV+S E++ + F Sbjct: 224 TIKADVFSYALCLWEILTGEIPF 246 >6FER-A nrPDB Length = 309 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 116/317 (36%), Gaps = 59/317 (18%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSA--------------MNSETNE--SVAIKKIANAFDN 100 E K +G+G +G V ++ N+ VA+K + A N Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-ADAN 63 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ 159 K L+EIK++ + NI+ + + + + + E M+ DL+Q + ++ Sbjct: 64 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITD-----DPLCMITEYMENGDLNQFLSRHE 118 Query: 160 A----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 +S + ++ QI G+KY+ S N +HRDL N L+ N +KI DFG Sbjct: 119 PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG 178 Query: 210 LARVTSESDFM----TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 ++R D+ + RW +LL +T A DVW+ G E F Sbjct: 179 MSRNLYSGDYYRIQGRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWETFT----FC 232 Query: 266 GRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 QL + T EF + ++ P S+ L+ Sbjct: 233 QEQPYSQLSDEQVIENTG-----EFFRDQGRQTYLPQPAICPDSVYK-----------LM 276 Query: 326 EKMLTFDPRRRITVLDA 342 D + R + + Sbjct: 277 LSCWRRDTKNRPSFQEI 293 >4X3F-A nrPDB Length = 337 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 35/283 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRH 116 ++ +Y+ I G G V A+++ VA+K + + F + + +R E + Sbjct: 10 LSGRYRLQ-RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 68 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILR 175 ++H I ++ D + Y+ EL++ + L+ +++ LS H L Q R Sbjct: 69 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE--YVVTRWYRAPE 233 L+ H+A ++HRD+KP N+L+ +KI DFG+A+ + + T Y APE Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L D + A DV+S+G + E + K F G Sbjct: 189 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD-------------------------- 221 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + + ++ P + P +LIE L +P R Sbjct: 222 ---GALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >4OW8-A nrPDB Length = 283 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 35/283 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRH 116 ++ +Y+ I G G V A+++ VA+K + + F + + +R E + Sbjct: 9 LSGRYRLQ-RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 67 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILR 175 ++H I ++ D + Y+ EL++ + L+ +++ LS H L Q R Sbjct: 68 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 127 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE--YVVTRWYRAPE 233 L+ H+A ++HRD+KP N+L+ +KI DFG+A+ + + T Y APE Sbjct: 128 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L D + A DV+S+G + E + K F G Sbjct: 188 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD-------------------------- 220 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + + ++ P + P +LIE L +P R Sbjct: 221 ---GALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 260 >2WTK-B nrPDB Length = 373 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 119/337 (35%), Gaps = 45/337 (13%) Query: 63 KPPIMPIGKGAYG--IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE 120 + IGKG V A T E V +++I + E+ + + +H Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN--QALSEEHCQYFLYQILRGL 177 NIV R N++++ M +I ++ ++E Y L +L+ L Sbjct: 71 NIVPYRATFIAD-----NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKAL 125 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGL----------ARVTSESDFMTEYVVTR 227 YIH +HR +K S++L++ + + + GL R DF V Sbjct: 126 DYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 228 WYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS-- 284 + +PE+L + Y A D++SVG EL + F +D LL +L GT Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF--KDMPATQMLLEKLNGTVPCL 241 Query: 285 -------------EEELEFLNENAKRYIRQLPPYPRQSITDKFP---TVHPLAIDLIEKM 328 N + P P + P T P +E+ Sbjct: 242 LDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQC 301 Query: 329 LTFDPRRRITVLDALAHPYLNSLHDISDE--PECTIP 363 L +P R + L H + + + E PE P Sbjct: 302 LQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRP 338 >6B2Q-A nrPDB Length = 317 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 116/283 (40%), Gaps = 35/283 (12%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRH 116 ++ +Y+ I G G V A+++ VA+K + + F + + +R E + Sbjct: 30 LSGRYRLQ-RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 88 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILR 175 ++H I ++ D + Y+ EL++ + L+ +++ LS H L Q R Sbjct: 89 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 148 Query: 176 GLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE--YVVTRWYRAPE 233 L+ H+A ++HRD+KP N+L+ +KI DFG+A+ + + T Y APE Sbjct: 149 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 L D + A DV+S+G + E + K F G Sbjct: 209 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD-------------------------- 241 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + + ++ P + P +LIE L +P R Sbjct: 242 ---GALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >3G0E-A nrPDB Length = 336 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 112/321 (34%), Gaps = 62/321 (19%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSA-----MNSETNESVAIKKIANAFDNKIDAKR 106 + + +E +G GA+G V A + S+ +VA+K + + + + + Sbjct: 37 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSA-HLTEREA 95 Query: 107 TLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ------ 159 + E+K+L ++ +H NIV + Y Y DL +R + Sbjct: 96 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCY----GDLLNFLRRKRDSFICS 151 Query: 160 ------------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICD 207 AL E F YQ+ +G+ ++ S N +HRDL N+LL KICD Sbjct: 152 KTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 211 Query: 208 FGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPL 263 FGLAR R + APE + N YT DVWS G EL Sbjct: 212 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSP 270 Query: 264 FPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 +PG + K R L P D Sbjct: 271 YPG------------------MPVDSKFYKMIKEGFRMLSP----------EHAPAEMYD 302 Query: 324 LIEKMLTFDPRRRITVLDALA 344 +++ DP +R T + Sbjct: 303 IMKTCWDADPLKRPTFKQIVQ 323 >5GRN-A nrPDB Length = 356 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 112/324 (34%), Gaps = 72/324 (22%) Query: 52 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-----SVAIKKIANAFDNKIDAKR 106 + + +E +G GA+G V + VA+K + + + + Sbjct: 37 YDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS-EKQA 95 Query: 107 TLREIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ----- 159 + E+K++ H+ H NIV + +YI E DL + N+ Sbjct: 96 LMSELKIMTHLGPHLNIVNLLGACTKS-----GPIYIITEYCFYGDLVNYLHKNRDSFLS 150 Query: 160 ---------------------ALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 198 L+ F YQ+ RG++++ S N +HRDL N+LL Sbjct: 151 HKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA 210 Query: 199 ANCDLKICDFGLARVTSESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFM 255 +KICDFGLAR T + APE + ++ YT DVWS G + Sbjct: 211 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDN-LYTTLSDVWSYGILLW 269 Query: 256 ELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKF 314 E+ +PG + F N+ Y P + Sbjct: 270 EIFSLGGTPYPGM-----------------MVDSTFYNKIKSGYRMAKPDH--------- 303 Query: 315 PTVHPLAIDLIEKMLTFDPRRRIT 338 +++ K +P +R + Sbjct: 304 --ATSEVYEIMVKCWNSEPEKRPS 325 >4X7Q-B nrPDB Length = 312 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 108/308 (35%), Gaps = 56/308 (18%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN----AFDNKIDAKRTLREIKLLRHMD----HE 120 +GKG +G V + VAIK I + D+ E+ LL + H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 ++ + D + + L DL I L E + F Q++ +++ Sbjct: 99 GVIRLLDWFETQEGF---MLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHC 155 Query: 181 HSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 239 HS V+HRD+K N+L++ K+ DFG + + + T++ TR Y PE + Sbjct: 156 HSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPEWISRHQ 214 Query: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 + VWS+G + +++ F E + + Sbjct: 215 YHALPATVWSLGILLYDMVCGDIPF----------------------------ERDQEIL 246 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPE 359 +P V P LI + L P R ++ + L P++ P Sbjct: 247 EAELHFPA--------HVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ-------TPA 291 Query: 360 CTIPFNFD 367 +P N Sbjct: 292 EDVPLNPS 299 >1FVR-A nrPDB Length = 327 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 106/298 (35%), Gaps = 59/298 (19%) Query: 68 PIGKGAYGIVCSAMNSETNESV--AIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 124 IG+G +G V A + + AIK++ + +K D + E+++L + H NI+ Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIIN 90 Query: 125 IRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQ----------------ALSEEHCQ 167 + +Y+A E +L +R ++ LS + Sbjct: 91 LLGACEHRGY-----LYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLL 145 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT-EYVVT 226 +F + RG+ Y+ +HRDL N+L+ N KI DFGL+R T + Sbjct: 146 HFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPV 205 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSE 285 RW A E L N S YT DVWS G + E++ + G L Sbjct: 206 RW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL--------- 254 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 P+ +K DL+ + P R + L Sbjct: 255 --------------------PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >6CTH-A nrPDB Length = 309 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 53/201 (26%), Positives = 100/201 (49%), Gaps = 15/201 (7%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+G +G V +++ +A+KK++ A +K K E+K++ + H+N+V + Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRLRHKNLVKLIG 79 Query: 128 IIPPPLRNAFNDVYIAYELM-DTDLHQII-RSNQALSEEHCQYFLYQILRGLKYIHS--- 182 ++ + YE M + L I + L+ E + + L Y+H Sbjct: 80 WCHE-----RGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGD 134 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV--VTRWYRAPELLLNSSD 240 VLHRD+K SN++L+++ + K+ DFGLAR+ + + + + T Y APE L +S Sbjct: 135 HCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL-SSGK 193 Query: 241 YTAAIDVWSVGCIFMELMDRK 261 + DV+S G + +E+ + Sbjct: 194 ASKESDVYSFGVVALEIASGR 214 >4HZS-A nrPDB Length = 341 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 54/241 (22%), Positives = 103/241 (42%), Gaps = 18/241 (7%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSA-MNSETNESV--AIKKIANAFDNKIDAKR-TLREIKL 113 + K + +G G++G+V ++ + ++V A+K + ++ +A +RE+ Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLY 171 + +DH N++ + ++ P + + EL L +R +Q + Sbjct: 69 MHSLDHRNLIRLYGVVLTP------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV 122 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTRW 228 Q+ G+ Y+ S +HRDL NLLL +KI DFGL R ++D M E+ + Sbjct: 123 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 182 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE L + ++ A D W G E+ + + G + L + + Sbjct: 183 AWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 241 Query: 287 E 287 E Sbjct: 242 E 242 >5AMN-A nrPDB Length = 299 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 115/296 (38%), Gaps = 35/296 (11%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETN-----ESVAIKKIANAFDNKIDAKRTLRE 110 +E K +G+G +G V A +VA+K + + + L E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPS-ELRDLLSE 76 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA--------- 160 +L+ ++H +++ + + + E L +R ++ Sbjct: 77 FNVLKQVNHPHVIKLYGACSQD-----GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDER 131 Query: 161 -LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF 219 L+ F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R E D Sbjct: 132 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 191 Query: 220 MTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRL 275 + R + A E L + YT DVWS G + E++ +PG Sbjct: 192 YVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGI----PPER 246 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 L L+ T E +N + +L + DK P ++ DL EKM+ Sbjct: 247 LFNLLKTGHRMERP---DNCSEEMYRLMLQCWKQEPDKRPVFADISKDL-EKMMVK 298 >4G3E-A nrPDB Length = 352 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 116/277 (41%), Gaps = 34/277 (12%) Query: 5 SGQPAADTEM--TEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKY 62 SGQ + + T + G P+ E + L+ + + Y + +T + Sbjct: 23 SGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGV--LLTEKLKPVDYEYREEVHWMTHQP 80 Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 + +G+G++G V + +T A+KK+ ++ R E+ + I Sbjct: 81 R-----VGRGSFGEVHRMKDKQTGFQCAVKKVR------LEVFRVE-ELVACAGLSSPRI 128 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIH 181 V + + V I EL++ L Q+I+ L E+ Y+L Q L GL+Y+H Sbjct: 129 VPLYGAVREGPW-----VNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLH 183 Query: 182 SANVLHRDLKPSNLLLNANC-DLKICDFGLARVTSESDFMTEYV------VTRWYRAPEL 234 + +LH D+K N+LL+++ +CDFG A + T + APE+ Sbjct: 184 TRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEV 243 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPL----FPGR 267 ++ A +D+WS C+ + +++ F G Sbjct: 244 VMG-KPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGP 279 >5U6C-A nrPDB Length = 315 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 114/291 (39%), Gaps = 23/291 (7%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSA---MNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 + +G+G +G V T+ VA+K + ++ + + L E + Sbjct: 33 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 92 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ------ALSEEHCQ 167 + H N++ + + + M DLH + ++ + + Sbjct: 93 KDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 152 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR 227 F+ I G++Y+ + N LHRDL N +L + + + DFGL++ D+ + + + Sbjct: 153 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 212 Query: 228 W---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTP 283 + A E L + YT+ DVW+ G E+ +PG + L L G Sbjct: 213 MPVKWIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL--LHGHR 269 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 ++ + L+E + ++ ++ PT L + L EK+L P Sbjct: 270 LKQPEDCLDE-----LYEIMYSCWRTDPLDRPTFSVLRLQL-EKLLESLPD 314 >3ZBF-A nrPDB Length = 322 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 120/330 (36%), Gaps = 67/330 (20%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAM-----NSETNE-SVAIKKIANAFDNKIDAKRTLREI 111 + + +G GA+G V + E VA+K + ++ + L+E Sbjct: 30 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ-EKIEFLKEA 88 Query: 112 KLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALS-------E 163 L+ +H NI+ + YI ELM+ DL +R + + Sbjct: 89 HLMSKFNHPNILKQLGVCLLN-----EPQYIILELMEGGDLLTYLRKARMATFYGPLLTL 143 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-----ANCDLKICDFGLARVTSESD 218 I +G Y+ + +HRDL N L++ + +KI DFGLAR ++D Sbjct: 144 VDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND 203 Query: 219 FMTEY----VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQL 273 + + + RW APE L++ +T DVWS G + E++ +P ++ L Sbjct: 204 YYRKRGEGLLPVRW-MAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL 261 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 + + R PP +L+ + +P Sbjct: 262 NYV-------------------QTGGRLEPPR----------NCPDDLWNLMTQCWAQEP 292 Query: 334 RRRITVL------DALAHPYLNSLHDISDE 357 +R T + +LNS++ DE Sbjct: 293 DQRPTFHRIQDQLQLFRNFFLNSIYKSRDE 322 >5VD3-A nrPDB Length = 311 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 102/289 (35%), Gaps = 40/289 (13%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENI 122 + +G G+YG V + E A+K+ + F D R L E+ + H Sbjct: 60 QRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCC 119 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIH 181 V + +Y+ EL L Q + +L E +L L L ++H Sbjct: 120 VRLEQAWEEG-----GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 174 Query: 182 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 241 S ++H D+KP+N+ L K+ DFGL + Y APELL S Y Sbjct: 175 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--Y 232 Query: 242 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 301 A DV+S+G +E+ L G + QLR G E Sbjct: 233 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFT------------- 274 Query: 302 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + ++ ML DP+ R T LA P L Sbjct: 275 -------------AGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >3PLS-A nrPDB Length = 298 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 112/283 (39%), Gaps = 46/283 (16%) Query: 67 MPIGKGAYGIVCSAMNSE---TNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IGKG +G+V + AIK ++ + + + LRE L+R ++H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVL 85 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHS 182 A+ I+ PP V + Y + DL Q IRS Q + + F Q+ RG++Y+ Sbjct: 86 ALIGIMLPP--EGLPHVLLPY-MCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAE 142 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT------EYVVTRWYRAPELLL 236 +HRDL N +L+ + +K+ DFGLAR + ++ + + +W A E L Sbjct: 143 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESLQ 201 Query: 237 NSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 +T DVWS G + EL+ P + D L + P E Sbjct: 202 TYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEY-------- 252 Query: 296 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 ++++ DP R T Sbjct: 253 ---------------------CPDSLYQVMQQCWEADPAVRPT 274 >3LZB-A nrPDB Length = 327 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 105/270 (38%), Gaps = 18/270 (6%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ Sbjct: 18 KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDN 76 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGL 177 ++ + I V + +LM L +R ++ + ++ + QI +G+ Sbjct: 77 PHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 130 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRW-YRAPEL 234 Y+ ++HRDL N+L+ +KI DFGLA++ E ++ E + A E Sbjct: 131 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 190 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L+ YT DVWS G ELM + G +L + P Sbjct: 191 ILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 249 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 R + R + +A D Sbjct: 250 MIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >4Y83-A nrPDB Length = 332 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 129/325 (39%), Gaps = 41/325 (12%) Query: 28 PQMPGIE-NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETN 86 PQ GI N+ T +G I ++ +++T + I +GA+G V A + +T Sbjct: 40 PQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGS-DFIPRGAFGKVYLAQDIKTK 98 Query: 87 ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYEL 146 + +A K I D +++ HENI + + V++ E Sbjct: 99 KRMACKLIPVDQFKPSD-------VEIQACFRHENIAELYGAV-----LWGETVHLFMEA 146 Query: 147 MDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKI 205 + + + + S + E + +L+GL ++HS V+H D+KPSN++ + + + Sbjct: 147 GEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-L 205 Query: 206 CDFGLARVTSESDFM-TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 DFGL+ +E + + T Y +PE++L ++ D++S+G + + P + Sbjct: 206 VDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPPW 264 Query: 265 PGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 + P +L K+ + D P +L Sbjct: 265 --------------VKRYPRSAYPSYLYIIHKQ---------APPLEDIADDCSPGMREL 301 Query: 325 IEKMLTFDPRRRITVLDALAHPYLN 349 IE L +P R D L H LN Sbjct: 302 IEASLERNPNHRPRAADLLKHEALN 326 >5GNK-A nrPDB Length = 297 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 109/284 (38%), Gaps = 19/284 (6%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ Sbjct: 22 KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDN 80 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQILRGL 177 ++ + I V + +LM L +R ++ + ++ + QI +G+ Sbjct: 81 PHVCRLLGICLTST------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 134 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRW-YRAPEL 234 Y+ ++HRDL N+L+ +KI DFGLA++ E ++ E + A E Sbjct: 135 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 194 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 293 +L+ YT DVWS G ELM + G +L + P Sbjct: 195 ILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVY 253 Query: 294 NAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 + R + +A D ++ L R+ Sbjct: 254 MIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 296 >1U54-B nrPDB Length = 291 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 54/241 (22%), Positives = 103/241 (42%), Gaps = 18/241 (7%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSA-MNSETNESV--AIKKIANAFDNKIDAKR-TLREIKL 113 + K + +G G++G+V ++ + ++V A+K + ++ +A +RE+ Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFLY 171 + +DH N++ + ++ P + + EL L +R +Q + Sbjct: 75 MHSLDHRNLIRLYGVVLTP------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV 128 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD---FMTEYVVTRW 228 Q+ G+ Y+ S +HRDL NLLL +KI DFGL R ++D M E+ + Sbjct: 129 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 188 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + APE L + ++ A D W G E+ + + G + L + + Sbjct: 189 AWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 247 Query: 287 E 287 E Sbjct: 248 E 248 >3PP0-A nrPDB Length = 338 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 101/277 (36%), Gaps = 18/277 (6%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIK 112 + + +G GA+G V + E+V AIK + K + K L E Sbjct: 13 ILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN-KEILDEAY 71 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEEHCQYFL 170 ++ + + + I V + +LM L +R N+ L + + Sbjct: 72 VMAGVGSPYVSRLLGICLTST------VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWC 125 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT--SESDFMTEYVVTRW 228 QI +G+ Y+ ++HRDL N+L+ + +KI DFGLAR+ E+++ + Sbjct: 126 MQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPI 185 Query: 229 -YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEE 286 + A E +L +T DVWS G ELM + G LL + P Sbjct: 186 KWMALESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPP 244 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 + R + +A D Sbjct: 245 ICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >5HLW-A nrPDB Length = 299 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 106/269 (39%), Gaps = 15/269 (5%) Query: 67 MPIGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG+G +G V N A+K + N + + + L E +++ H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHS 182 ++ I LR+ + + + + DL IR + + F Q+ +G+KY+ S Sbjct: 85 SLLGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 141 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-----YRAPELLLN 237 +HRDL N +L+ +K+ DFGLAR + ++ + + T + A E L Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL-Q 200 Query: 238 SSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 + +T DVWS G + ELM P +P + L++ E Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 260 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 R S ++ + + I Sbjct: 261 LKCWHPKAEMRPSFSELVSRISAIFSTFI 289 >5FM2-A nrPDB Length = 355 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 72/360 (20%), Positives = 132/360 (36%), Gaps = 54/360 (15%) Query: 8 PAADTEMTEAPGGFPAA--APSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPP 65 +A+ FP + + + P ++++ +S I + +E K Sbjct: 12 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILED---PKWEFPRKNLVL 68 Query: 66 IMPIGKGAYGIVCSAMNSETN-----ESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHE 120 +G+G +G V A +VA+K + + + L E +L+ ++H Sbjct: 69 GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPS-ELRDLLSEFNVLKQVNHP 127 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------------------- 160 +++ + + + E L +R ++ Sbjct: 128 HVIKLYGACSQD-----GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 182 Query: 161 -----LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS 215 L+ F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R Sbjct: 183 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 242 Query: 216 ESDFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVH 271 E D + R + A E L + YT DVWS G + E++ +PG Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGI---- 297 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 L L+ T E +N + +L + DK P ++ DL EKM+ Sbjct: 298 PPERLFNLLKTGHRMERP---DNCSEEMYRLMLQCWKQEPDKRPVFADISKDL-EKMMVK 353 >4NEU-A nrPDB Length = 333 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 59/349 (16%), Positives = 129/349 (36%), Gaps = 50/349 (14%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 Q ++ N+ ++ + + G +G V + + +K + + + Sbjct: 11 QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEAL 69 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHC 166 L E K++ + H +V + +I + + + E M+ +L ++++ + Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYS-----LVMEYMEKGNLMHVLKAEMSTPLSVK 124 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA--------------R 212 + +I+ G+ Y+H V+H+DLKP N+L++ + +KI D GLA Sbjct: 125 GRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNE 184 Query: 213 VTSESDFMTEYVVTRWYRAPELLLN-SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 + + T +Y APE L + ++ T DV+S + + K + Sbjct: 185 LREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQ 244 Query: 272 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 QL + ++ P +++ I L++ Sbjct: 245 QLIMCIKSGNRPDVDDITEY-------------------------CPREIISLMKLCWEA 279 Query: 332 DPRRRIT---VLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQ 377 +P R T + + YL+ L + +E ++ + EN + Q Sbjct: 280 NPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQ 328 >4PL5-B nrPDB Length = 435 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 84/301 (27%), Positives = 124/301 (41%), Gaps = 54/301 (17%) Query: 68 PIGKGAYGI-VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAI 125 +G GA G V M N VA+K+I + D RE++LLR D H N++ Sbjct: 34 VLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 86 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIHSA 183 R YIA EL L + + L E L+Q GL ++HS Sbjct: 87 --FCTEKDR---QFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSL 140 Query: 184 NVLHRDLKPSNLLL---NANCDLK--ICDFGLARVTSES----DFMTEYVVTRWYRAPEL 234 N++HRDLKP N+LL NA+ +K I DFGL + + + T + APE+ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 235 LLNSSDY--TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 L T +D++S GC+F ++ G+ Q +L+ Sbjct: 201 LSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFH------ 254 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 +DK V +A +LIEKM+ DP++R + L HP+ SL Sbjct: 255 ------------------SDKHEDV--IARELIEKMIAMDPQQRPSAKHVLKHPFFWSLE 294 Query: 353 D 353 Sbjct: 295 K 295 >5LPZ-A nrPDB Length = 332 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 103/233 (44%), Gaps = 11/233 (4%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 + ++ F ++ + T + IG G +G V A+ + +VAIKK+ + Sbjct: 2 KPLRKLAFADLLQATNGFHND-SLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQ--GD 57 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 + + E++ + + H N+V + ++ Y ++ LH ++ L+ Sbjct: 58 REFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWS 117 Query: 165 HCQYFLYQILRGLKYIHSA---NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-- 219 + RGL ++H +++HRD+K SN+LL+ N + ++ DFG+AR+ S D Sbjct: 118 TRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHL 177 Query: 220 -MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 ++ T Y PE + + DV+S G + +EL+ K D Sbjct: 178 SVSTLAGTPGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGD 229 >3AOX-A nrPDB Length = 344 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 106/312 (33%), Gaps = 58/312 (18%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRTL 108 ++ EV K I +G GA+G V N + VA+K + + D L Sbjct: 40 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ-DELDFL 98 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA------- 160 E ++ +H+NIV + L +I ELM DL +R + Sbjct: 99 MEALIISKFNHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRETRPRPSQPSS 153 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC---DLKICDFGLARVTSES 217 L+ + I G +Y+ + +HRD+ N LL KI DFG+AR + Sbjct: 154 LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA 213 Query: 218 DFMTE----YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQ 272 + + + +W PE + +T+ D WS G + E+ +P + + Sbjct: 214 SYYRKGGCAMLPVKW-MPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEV 271 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 L EF+ + + P P I + + Sbjct: 272 L---------------EFVTSGGRMDPPKNCPGPVYRI--------------MTQCWQHQ 302 Query: 333 PRRRITVLDALA 344 P R L Sbjct: 303 PEDRPNFAIILE 314 >2RIO-A nrPDB Length = 434 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 83/328 (25%), Positives = 129/328 (39%), Gaps = 70/328 (21%) Query: 56 FEVTAKYKPPIMPI-GKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 114 FE + K I G G+ G V S VA+K++ F L EIKLL Sbjct: 9 FEQSLKNLVVSEKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDF-----CDIALMEIKLL 62 Query: 115 RHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ------ 167 D H N++ +YIA EL + +L ++ S E Sbjct: 63 TESDDHPNVIRYY-----CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNP 117 Query: 168 -YFLYQILRGLKYIHSANVLHRDLKPSNLLLN-------------ANCDLKICDFGLARV 213 L QI G+ ++HS ++HRDLKP N+L++ N + I DFGL + Sbjct: 118 ISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKK 177 Query: 214 TSESD-----FMTEYVVTRWYRAPELLLN------SSDYTAAIDVWSVGCIFMELMD-RK 261 + T +RAPELL T +ID++S+GC+F ++ K Sbjct: 178 LDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGK 237 Query: 262 PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLA 321 F G + + ++ G S +E++ L++ ++ A Sbjct: 238 HPF-GDKYSRESNIIR---GIFSLDEMKCLHDR---------------------SLIAEA 272 Query: 322 IDLIEKMLTFDPRRRITVLDALAHPYLN 349 DLI +M+ DP +R T + L HP Sbjct: 273 TDLISQMIDHDPLKRPTAMKVLRHPLFW 300 >6HV0-A nrPDB Length = 416 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 82/301 (27%), Positives = 125/301 (41%), Gaps = 54/301 (17%) Query: 68 PIGKGAYGI-VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAI 125 +G GA G V M N VA+K+I + D RE++LLR D H N++ Sbjct: 15 VLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYFLYQILRGLKYIHSA 183 R YIA EL L + + L E L Q GL ++HS Sbjct: 68 --FCTEKDR---QFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSL 121 Query: 184 NVLHRDLKPSNLLL---NANCDLK--ICDFGLARVTSES----DFMTEYVVTRWYRAPEL 234 N++HRDLKP N+L+ NA+ +K I DFGL + + + T + APE+ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 235 LLN--SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 L + T +D++S GC+F ++ G+ Q +L+ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS----------- 230 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 + L P + + +A +LIEKM+ DP++R + L HP+ SL Sbjct: 231 ------LDCLHPEKHEDV---------IARELIEKMIAMDPQKRPSAKHVLKHPFFWSLE 275 Query: 353 D 353 Sbjct: 276 K 276 >5LPV-A nrPDB Length = 296 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 103/233 (44%), Gaps = 11/233 (4%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 104 + ++ F ++ + T + IG G +G V A+ + +VAIKK+ + Sbjct: 2 KPLRKLAFADLLQATNGFHND-SLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQ--GD 57 Query: 105 KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 164 + + E++ + + H N+V + ++ Y ++ LH ++ L+ Sbjct: 58 REFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWS 117 Query: 165 HCQYFLYQILRGLKYIHSA---NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF-- 219 + RGL ++H +++HRD+K SN+LL+ N + ++ DFG+AR+ S D Sbjct: 118 TRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHL 177 Query: 220 -MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVH 271 ++ T Y PE + + DV+S G + +EL+ K D Sbjct: 178 SVSTLAGTPGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGD 229 >3C1X-A nrPDB Length = 373 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 106/269 (39%), Gaps = 15/269 (5%) Query: 67 MPIGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV 123 IG+G +G V N A+K + N + + + L E +++ H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHS 182 ++ I LR+ + + + + DL IR + + F Q+ +G+K++ S Sbjct: 154 SLLGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLAS 210 Query: 183 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW-----YRAPELLLN 237 +HRDL N +L+ +K+ DFGLAR + +F + + T + A E L Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL-Q 269 Query: 238 SSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK 296 + +T DVWS G + ELM P +P + L++ E Sbjct: 270 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 297 RYIRQLPPYPRQSITDKFPTVHPLAIDLI 325 R S ++ + + I Sbjct: 330 LKCWHPKAEMRPSFSELVSRISAIFSTFI 358 >6J5U-C nrPDB Length = 426 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 113/292 (38%), Gaps = 37/292 (12%) Query: 69 IGKGAYGIVCSAMNSET---------NESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 +G+G +G V +T VA+K++ + K L E+ L + H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKP--EGFQGHKEWLTEVNYLGQLSH 149 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQII--RSNQALSEEHCQYFLYQILRG 176 N+V + + YE M L + R Q L+ +G Sbjct: 150 PNLVLLVGYCAEGENR-----LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKG 204 Query: 177 LKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM---TEYVVTRWYRA 231 L ++H A V++RD K +N+LL+A+ + K+ DFGLA+ D T+ + T Y A Sbjct: 205 LTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAA 264 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE + + TA DV+S G + +EL+ + + ++ L+ TP + L Sbjct: 265 PEYVA-TGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVD--WATPYLGDKRKL 321 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 + P A +L + L D + R + + L Sbjct: 322 FRIMDTKLGGQYPQKGAF----------TAANLALQCLNPDAKLRPKMSEVL 363 >2BUJ-A nrPDB Length = 317 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 120/317 (37%), Gaps = 53/317 (16%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 112 G++ + K+ I +G+G + V A+K+I + D + RE Sbjct: 21 GHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREAD 78 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-----TDLHQIIRSNQALSEEHCQ 167 + R +H NI+ + R A ++ ++ ++ ++ L+E+ Sbjct: 79 MHRLFNHPNILRLVAYCLRE-RGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQIL 137 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL---ARVTSESDFMTEYV 224 + L I RGL+ IH+ HRDLKP+N+LL + D G A + E + Sbjct: 138 WLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTL 197 Query: 225 V-------TRWYRAPELLLNSSDY--TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 T YRAPEL S DVWS+GC+ +M + + D V Q Sbjct: 198 QDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY---DMVFQKGD 254 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 + L A + +P PR L+ M+T DP + Sbjct: 255 SVAL---------------AVQNQLSIPQSPRH---------SSALWQLLNSMMTVDPHQ 290 Query: 336 R------ITVLDALAHP 346 R ++ L+AL P Sbjct: 291 RPHIPLLLSQLEALQPP 307 >2PMN-X nrPDB Length = 348 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 122/317 (38%), Gaps = 48/317 (15%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA---------------KR 106 I + +G + + + N+ A+KK + K Sbjct: 32 DYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 107 TLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL----- 161 E++++ + +E + II +++VYI YE M+ D I++ ++ Sbjct: 90 FKNELQIITDIKNEYCLTCEGIIT-----NYDEVYIIYEYMEND--SILKFDEYFFVLDK 142 Query: 162 ------SEEHCQYFLYQILRGLKYIH-SANVLHRDLKPSNLLLNANCDLKICDFGLARVT 214 + + + +L YIH N+ HRD+KPSN+L++ N +K+ DFG + Sbjct: 143 NYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYM 202 Query: 215 SESDFMTEYVVTRWYRAPELLLNSSDY-TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQL 273 + + T + PE N S Y A +D+WS+G + F + Sbjct: 203 VD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKIS---- 257 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 L+EL + +E+ + L P + T + ID ++ L +P Sbjct: 258 --LVELFNNIRTKNIEYPLDRNHF----LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNP 311 Query: 334 RRRITVLDALAHPYLNS 350 RIT DAL H +L Sbjct: 312 AERITSEDALKHEWLAD 328 >4LRM-A nrPDB Length = 334 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 109/287 (37%), Gaps = 22/287 (7%) Query: 64 PPIMPIGKGAYGIVCSAMNSETNESV----AIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 I +G GA+G V + E V AIK++ A K + K L E ++ +D+ Sbjct: 22 KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASVDN 80 Query: 120 E---NIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ-ALSEEHCQYFLYQIL 174 ++ + I V + +LM L +R ++ + ++ + QI Sbjct: 81 PGNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 134 Query: 175 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRW-YRA 231 +G+ Y+ ++HRDL N+L+ +KI DFGLA++ E ++ E + A Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 194 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 E +L+ YT DVWS G ELM + G +L + P Sbjct: 195 LESILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTI 253 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 + R + +A D ++ L R+ Sbjct: 254 DVYMIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 299 >3Q4U-A nrPDB Length = 301 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 123/306 (40%), Gaps = 38/306 (12%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR--HM 117 A+ + +GKG YG V E+VA+K + D K RE +L + Sbjct: 7 ARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIF-----SSRDEKSWFRETELYNTVML 59 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRG 176 HENI+ R++ +++ + L+ ++ L C + I G Sbjct: 60 RHENILGFIAS-DMTSRHSSTQLWLITHYHEMGSLYDYLQLT-TLDTVSCLRIVLSIASG 117 Query: 177 LKYIH--------SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM-----TEY 223 L ++H + HRDLK N+L+ N I D GLA + S+S Sbjct: 118 LAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPR 177 Query: 224 VVTRWYRAPELLLNSSDYT-----AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 V T+ Y APE+L + +D+W+ G + E+ R+ + G ++ Sbjct: 178 VGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA-RRMVSNGIVEDYKPPFYDV 236 Query: 279 LIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 + PS E++ + +Q P P + +D PT+ LA L+++ +P R+T Sbjct: 237 VPNDPSFEDMRKVV----CVDQQRPNIPNRWFSD--PTLTSLAK-LMKECWYQNPSARLT 289 Query: 339 VLDALA 344 L Sbjct: 290 ALRIKK 295 >3QD2-B nrPDB Length = 332 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 134/340 (39%), Gaps = 87/340 (25%) Query: 60 AKYKPPIMPI---GKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++Y PI G+G +G+V A N + + AIK+I + ++ ++ +RE+K L Sbjct: 2 SRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAK 60 Query: 117 MDHENIVAIRDIIPPPLRNAFND------------------------------------- 139 ++H IV + + + Sbjct: 61 LEHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFST 120 Query: 140 ---------------VYIAYELMDTD-LHQIIRSNQALSEEH---CQYFLYQILRGLKYI 180 +YI +L + L + +L + C + QI ++++ Sbjct: 121 KNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFL 180 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD-------------FMTEYVVTR 227 HS ++HRDLKPSN+ + +K+ DFGL + + T V T+ Sbjct: 181 HSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTK 240 Query: 228 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 Y +PE + + ++Y+ +D++S+G I EL+ + + ++R++ ++ Sbjct: 241 LYMSPEQI-HGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDV------RN 288 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 L+F ++Y ++ Q + PT P A D+IE Sbjct: 289 LKFPLLFTQKYPQEHMMV--QDMLSPSPTERPEATDIIEN 326 >4JLC-A nrPDB Length = 657 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 89/213 (41%), Gaps = 21/213 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + A+K N +F +D + +RE ++L+ ++H+NIV + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 73 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 I + E L+ ++ L E L ++ G+ ++ Sbjct: 74 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 184 NVLHRDLKPSNLL--LNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 ++HRD+KP N++ + + K+ DFG AR + + T Y P++ Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 190 Query: 237 ----NSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 + Y A +D+WSVG F F Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >6DC0-A nrPDB Length = 292 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 102/280 (36%), Gaps = 48/280 (17%) Query: 77 VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRN 135 V A+ T + K K +I+ + H NI I ++I + Sbjct: 22 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 73 Query: 136 AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL 195 Y+ +E D+H +RS + L EE QI+ + + H + ++ DLK Sbjct: 74 -----YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 128 Query: 196 LLN--ANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSDY-TAAIDVWSVG 251 + + L++ + E D +++ Y +PE+L + Y A DVWS+G Sbjct: 129 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 188 Query: 252 CIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSIT 311 + L+ + F D + +R +P + Sbjct: 189 VMLYTLLVGRYPFHDSDPSALFSKI-------------------RRGQFCIPEH------ 223 Query: 312 DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + P A LI +L +P R+T + L HP+ S+ Sbjct: 224 -----ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >5CEK-A nrPDB Length = 263 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 102/280 (36%), Gaps = 48/280 (17%) Query: 77 VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRN 135 V A+ T + K K +I+ + H NI I ++I + Sbjct: 25 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 76 Query: 136 AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL 195 Y+ +E D+H +RS + L EE QI+ + + H + ++ DLK Sbjct: 77 -----YVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 131 Query: 196 LLN--ANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSDY-TAAIDVWSVG 251 + + L++ + E D +++ Y +PE+L + Y A DVWS+G Sbjct: 132 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 191 Query: 252 CIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSIT 311 + L+ + F D + +R +P + Sbjct: 192 VMLYTLLVGRYPFHDSDPSALFSKI-------------------RRGQFCIPEH------ 226 Query: 312 DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 351 + P A LI +L +P R+T + L HP+ S+ Sbjct: 227 -----ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >4EUU-A nrPDB Length = 319 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 21/213 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 74 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 I + E L+ ++ L E L ++ G+ ++ Sbjct: 75 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 184 NVLHRDLKPSNLL--LNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 ++HR++KP N++ + + K+ DFG AR + + T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 237 ----NSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 + Y A +D+WS+G F F Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >3UIM-A nrPDB Length = 326 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 60/324 (18%), Positives = 121/324 (37%), Gaps = 30/324 (9%) Query: 29 QMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNES 88 +P E+ L RF + +V + +G+G +G V Sbjct: 3 DVPAEEDPEVHLGQLKRFSLREL-----QVASDNFSNKNILGRGGFGKVYKGR-LADGTL 56 Query: 89 VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD 148 VA+K++ + + E++++ H N++ +R P Y+A + Sbjct: 57 VAVKRLKEERTQGGELQ-FQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVA 115 Query: 149 TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA---NVLHRDLKPSNLLLNANCDLKI 205 + L + S L Q RGL Y+H ++HRD+K +N+LL+ + + Sbjct: 116 SCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVV 175 Query: 206 CDFGLARVTS--ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL 263 DFGLA++ ++ T T + APE L ++ + DV+ G + +EL+ + Sbjct: 176 GDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL-STGKSSEKTDVFGYGVMLLELITGQRA 234 Query: 264 FPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAID 323 F + + ++ L + K +++ + + Sbjct: 235 FD--------------LARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQ 280 Query: 324 LIE-KML--TFDPRRRITVLDALA 344 LI+ +L P R + + + Sbjct: 281 LIQVALLCTQSSPMERPKMSEVVR 304 >4FL3-A nrPDB Length = 635 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 111/273 (40%), Gaps = 21/273 (7%) Query: 14 MTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGA 73 A P P + P R + + + + K +G G Sbjct: 328 APWAADKGPQREALPMDTEVFESPFADPEEIRPKEVYLDRKLLTLEDK------ELGSGN 381 Query: 74 YGIVCSAMNS--ETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPP 131 +G V + ++VA+K + N ++ L E +++ +D+ IV + I Sbjct: 382 FGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEA 441 Query: 132 PLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDL 190 + E+ + L++ ++ N+ + +++ ++Q+ G+KY+ +N +HRDL Sbjct: 442 ESWM------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 Query: 191 KPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRW---YRAPELLLNSSDYTAAID 246 N+LL KI DFGL++ ++ ++ +W + APE + N +++ D Sbjct: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKSD 554 Query: 247 VWSVGCIFMELMD-RKPLFPGRDHVHQLRLLME 278 VWS G + E + + G +L + Sbjct: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 >4EUT-A nrPDB Length = 396 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 21/213 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 74 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 I + E L+ ++ L E L ++ G+ ++ Sbjct: 75 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 184 NVLHRDLKPSNLL--LNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 ++HR++KP N++ + + K+ DFG AR + + T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 237 ----NSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 + Y A +D+WS+G F F Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >3MDY-A nrPDB Length = 337 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 120/299 (40%), Gaps = 34/299 (11%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH 119 AK + IGKG YG V E VA+K + + + + L+R H Sbjct: 36 AKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR---H 90 Query: 120 ENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 ENI+ ++ +Y+ + + L+ ++S L + Y + GL Sbjct: 91 ENILGFIAA-DIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSVSGLC 148 Query: 179 YIH--------SANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFM----TEYVV 225 ++H + HRDLK N+L+ N I D GLA + S+++ + V Sbjct: 149 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 226 TRWYRAPELL---LNSSDYTAA--IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELI 280 T+ Y PE+L LN + + + D++S G I E+ R + G +QL + Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRC-VSGGIVEEYQLPYHDLVP 267 Query: 281 GTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 PS E++ + + P +P + +D+ L+ + +P R+T Sbjct: 268 SDPSYEDMREIV----CIKKLRPSFPNRWSSDECLRQMGK---LMTECWAHNPASRLTA 319 >6O8B-A nrPDB Length = 665 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 90/213 (42%), Gaps = 21/213 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 80 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 I + E L+ ++ L E L ++ G+ ++ Sbjct: 81 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 137 Query: 184 NVLHRDLKPSNLL--LNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 ++HR++KP N++ + + K+ DFG AR + + E T Y P++ Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAV 197 Query: 237 ----NSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 + Y A +D+WS+G F F Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 230 >3SOC-A nrPDB Length = 322 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 64/287 (22%), Positives = 108/287 (37%), Gaps = 32/287 (11%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIP 130 +G +G V A NE VA+K + E+ L M HENI+ Sbjct: 34 RGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENILQFIGA-E 87 Query: 131 PPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS------- 182 + D+++ + L +++N +S + + RGL Y+H Sbjct: 88 KRGTSVDVDLWLITAFHEKGSLSDFLKAN-VVSWNELCHIAETMARGLAYLHEDIPGLKD 146 Query: 183 ---ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF---MTEYVVTRWYRAPELLL 236 + HRD+K N+LL N I DFGLA V TR Y APE+L Sbjct: 147 GHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLE 206 Query: 237 NSSDYTA----AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLN 292 + ++ ID++++G + EL R G + L E+ PS E+++ + Sbjct: 207 GAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVV 266 Query: 293 ENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 + K+ + + + IE+ D R++ Sbjct: 267 VHKKKRPVLRDYWQKHAGMAMLCET-------IEECWDHDAEARLSA 306 >4F0G-A nrPDB Length = 287 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 115/286 (40%), Gaps = 50/286 (17%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-----KRTLREIKLLRHMDHEN 121 IGKG +G+V + VAIK + + RE+ ++ +++H N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMD-TDL-HQIIRSNQALSEEHCQYFLYQILRGLKY 179 IV + ++ P R + E + DL H+++ + + I G++Y Sbjct: 85 IVKLYGLMHNPPR-------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEY 137 Query: 180 IHSAN--VLHRDLKPSNLL---LNANCDL--KICDFGLARVTSESDFMTEYVVTRWYRAP 232 + + N ++HRDL+ N+ L+ N + K+ DFGL++ + S ++ + + AP Sbjct: 138 MQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQWMAP 195 Query: 233 ELL-LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 E + YT D +S I ++ + F S +++F+ Sbjct: 196 ETIGAEEESYTEKADTYSFAMILYTILTGEGPFD----------------EYSYGKIKFI 239 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 N + +R P P P ++IE + DP++R Sbjct: 240 NMIREEGLR--PTIPED--------CPPRLRNVIELCWSGDPKKRP 275 >3ZZW-A nrPDB Length = 289 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 101/261 (38%), Gaps = 33/261 (12%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRT 107 G + E++ + +G+ +G V E ++VAIK + + + + + Sbjct: 1 GKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEF 59 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA------ 160 E L + H N+V + ++ + + + DLH+ + Sbjct: 60 RHEAMLRARLQHPNVVCLLGVVTKD-----QPLSMIFSYCSHGDLHEFLVMRSPHSDVGS 114 Query: 161 ----------LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGL 210 L + + QI G++Y+ S +V+H+DL N+L+ ++KI D GL Sbjct: 115 TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 174 Query: 211 ARVTSESDFMTEYVVTR---WYRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 R +D+ + + APE ++ ++ D+WS G + E+ + G Sbjct: 175 FREVYAADYYKLLGNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCG 233 Query: 267 RDHVHQLRLLMELIGTPSEEE 287 + + ++ P ++ Sbjct: 234 YSNQDVVEMIRNRQVLPCPDD 254 >6NT9-A nrPDB Length = 742 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 21/213 (9%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 127 +G+GA V + +T + AIK N +F +D + +RE ++L+ ++H+NIV + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72 Query: 128 IIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ---ALSEEHCQYFLYQILRGLKYIHSA 183 I + E L+ ++ L E L ++ G+ ++ Sbjct: 73 I---EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 184 NVLHRDLKPSNLL--LNANCD--LKICDFGLARVTSESDFMTEYVVTRWYRAPELLL--- 236 ++HR++KP N++ + + K+ DFG AR + + T Y P++ Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 Query: 237 ----NSSDYTAAIDVWSVGCIFMELMDRKPLFP 265 + Y A +D+WS+G F F Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 >5WNO-A nrPDB Length = 330 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 60/331 (18%), Positives = 113/331 (34%), Gaps = 59/331 (17%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMN-----SETNESVAIKKIANAFDNKIDAKRTLREIKL 113 + +G GA+G V + + VAIK ++ L E Sbjct: 20 SELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF---QTDQSQTDEMLEEATN 76 Query: 114 LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQ 172 + + H+N++ I +Y +L ++ + L + YQ Sbjct: 77 MFRLRHDNLLKIIGFCMHDDGLKIVTIYRPL----GNLQNFLKLHKENLGAREQVLYCYQ 132 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES----DFMTEYVVTRW 228 I G++Y+ V+HRDL N+L+ ++I DFGL+++ + V +W Sbjct: 133 IASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW 192 Query: 229 YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTPSEEE 287 A E + + YT A DVW+ G E++ + + G ++ Sbjct: 193 -LAIE-IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMS---------------TDSI 235 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 347 FL + + + P + + DP+ R Sbjct: 236 HNFLKDGNR--------------LSQPPNCSQDLYQELLRCWMADPKSRPG--------- 272 Query: 348 LNSLHDISDEPECTIPFNFDFENHALSEEQM 378 L++ E C +P F ++ +SE + Sbjct: 273 FEILYERFKE-FCKVPQLFLENSNKISESDL 302 >3MY0-A nrPDB Length = 305 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 124/321 (38%), Gaps = 43/321 (13%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH--M 117 A+ + +GKG YG V + ESVA+K + D + RE ++ + Sbjct: 7 ARQVALVECVGKGRYGEVWRGLWH--GESVAVKIF-----SSRDEQSWFRETEIYNTVLL 59 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRG 176 H+NI+ RN+ +++ + L+ ++ Q L G Sbjct: 60 RHDNILGFIAS-DMTSRNSSTQLWLITHYHEHGSLYDFLQ-RQTLEPHLALRLAVSAACG 117 Query: 177 LKYIH--------SANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM-----TEY 223 L ++H + HRD K N+L+ +N I D GLA + S+ Sbjct: 118 LAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPR 177 Query: 224 VVTRWYRAPELLLNSSDYT-----AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLME 278 V T+ Y APE+L D+W+ G + E+ R+ + G ++ Sbjct: 178 VGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA-RRTIVNGIVEDYRPPFYDV 236 Query: 279 LIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 + PS E+++ + +Q P P + D P + LA ++ + +P R+T Sbjct: 237 VPNDPSFEDMKKVV----CVDQQTPTIPNRLAAD--PVLSGLAQ-MMRECWYPNPSARLT 289 Query: 339 VLDALAHPYLNSLHDISDEPE 359 L +L IS+ PE Sbjct: 290 ALRIKK-----TLQKISNSPE 305 >5TE0-A nrPDB Length = 347 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 113/316 (35%), Gaps = 58/316 (18%) Query: 47 IQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR 106 + G +F + + + +G + IV + A+K++ +N+ D + Sbjct: 5 LGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMF--VNNEHDLQV 61 Query: 107 TLREIKLLRHMD-HENIVAIRDI-IPPPLRNAFNDVYIAYELMDTD-----LHQIIRSNQ 159 REI+++R + H+NIV D I +V I + ++Q +++ Sbjct: 62 CKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQT-- 119 Query: 160 ALSEEHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARVTSES 217 +E + +H ++HRDLK N+LL+ +CDFG A ++ Sbjct: 120 GFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQN 179 Query: 218 DFM---------TEYVVTRWYRAPEL--LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPG 266 + T YRAPE+ L + T D+W++GC+ +L F G Sbjct: 180 PQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-G 238 Query: 267 RDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 V + F + RY + + LI Sbjct: 239 ESQVAIC-------------DGNFTIPDNSRYSQDMH-------------------CLIR 266 Query: 327 KMLTFDPRRRITVLDA 342 ML DP +R + Sbjct: 267 YMLEPDPDKRPDIYQV 282 >5C26-A nrPDB Length = 299 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 48/220 (21%), Positives = 100/220 (45%), Gaps = 15/220 (6%) Query: 67 MPIGKGAYGIVCSAMNS--ETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 +G G +G V + ++VA+K + N ++ L E +++ +D+ IV Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 125 IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + I + E+ + L++ ++ N+ + +++ ++Q+ G+KY+ + Sbjct: 93 MIGICEAESWM------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 146 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRW---YRAPELLLNSS 239 N +HRDL N+LL KI DFGL++ ++ ++ +W + APE + N Sbjct: 147 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYY 205 Query: 240 DYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLME 278 +++ DVWS G + E + + G +L + Sbjct: 206 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 245 >5IKW-A nrPDB Length = 310 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 115/333 (34%), Gaps = 60/333 (18%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 ++ +F V + +G + V + A+K++ +N D R Sbjct: 3 SVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMY--VNNMPDLNVCKR 59 Query: 110 EIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTD-----LHQIIRSNQALSE 163 EI +++ + H+NIV D + + +V I E +++ +++ +E Sbjct: 60 EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQT--GFTE 117 Query: 164 EHCQYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLAR---VTSESD 218 + +H ++HRDLK N+LLN + +CDFG A + + D Sbjct: 118 PEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKD 177 Query: 219 FMT------EYVVTRWYRAPELL--LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHV 270 + + T YRAPE++ T D+W++GC+ +L F G V Sbjct: 178 GVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQV 236 Query: 271 HQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 + F + RY R + LI ML Sbjct: 237 AIC-------------DGNFTIPDNSRYSRNIH-------------------CLIRFMLE 264 Query: 331 FDPRRRITVLDALAHPYLNSLHDISDEPECTIP 363 DP R + Y +D P I Sbjct: 265 PDPEHRPDIFQV---SYFAFKFAAADCPVSNIN 294 >1PY5-A nrPDB Length = 326 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 114/297 (38%), Gaps = 38/297 (12%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR--HMDHENIVAIR 126 IGKG +G V E VA+K + + + RE ++ + + HENI+ Sbjct: 37 IGKGRFGEVWRGKWR--GEEVAVKIF-----SSREERSWFREAEIYQTVMLRHENILGFI 89 Query: 127 DIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH---- 181 + +++ + + L + + ++ E GL ++H Sbjct: 90 AA-DNKDNGTWTQLWLVSDYHEHGSLFDYL-NRYTVTVEGMIKLALSTASGLAHLHMEIV 147 Query: 182 ----SANVLHRDLKPSNLLLNANCDLKICDFGLA-RVTSESDFM----TEYVVTRWYRAP 232 + HRDLK N+L+ N I D GLA R S +D + V T+ Y AP Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 233 ELL---LNSSDY--TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 E+L +N + D++++G +F E+ R + G +QL + PS EE Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEE 266 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 + + K P P + + + V ++ + + R+T L Sbjct: 267 MRKVVCEQK----LRPNIPNRWQSCEALRVMAK---IMRECWYANGAARLTALRIKK 316 >4M66-A nrPDB Length = 325 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 97/215 (45%), Gaps = 19/215 (8%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 V+ + + +GKG +G+V A + N VA+K + ++K+ E+K + ++ Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIV--------NSKKISWEVKAMVNL 68 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRG 176 +EN++ + + + + + M+ L +++ L +++ G Sbjct: 69 RNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLG 128 Query: 177 LKYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARVT-------SESDFMTEYVVTR 227 + Y+HS + +LHRDLKPSN+LL+ K+ DFGL+ + T Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTL 188 Query: 228 WYRAPELLLNSS-DYTAAIDVWSVGCIFMELMDRK 261 Y PELL + + A DV+S G + ++ + Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5XD6-A nrPDB Length = 305 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 56/223 (25%), Positives = 97/223 (43%), Gaps = 27/223 (12%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 ++T Y IG+G+YG V + + ++ AIKK+ ++ + L ++ ++ Sbjct: 19 DITDNYGSK-SLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSR 73 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQA---------LSEEHC 166 + EN+VA+ +AYE + LH I+ + LS Sbjct: 74 LRQENVVALLGYCVDGPLR-----VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQR 128 Query: 167 QYFLYQILRGLKYIHSA---NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM--- 220 RGL+Y+H +V+HRD+K SN+LL + KI DF L+ + Sbjct: 129 VKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHS 188 Query: 221 TEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPL 263 T + T Y APE + + + DV+S G + +EL+ + Sbjct: 189 TRVLGTFGYHAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKP 230 >3G2F-A nrPDB Length = 336 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 112/307 (36%), Gaps = 43/307 (14%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR--HMDHE 120 + IG+G YG V S VA+K + + + + E + R M+H+ Sbjct: 15 LKLLELIGRGRYGAVYKG--SLDERPVAVKVF-----SFANRQNFINEKNIYRVPLMEHD 67 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQIIRSNQALSEEHCQYFLYQILRGLKY 179 NI + + + E + L + + + + + + RGL Y Sbjct: 68 NIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTRGLAY 126 Query: 180 IH---------SANVLHRDLKPSNLLLNANCDLKICDFGLA---------RVTSESDFMT 221 +H + HRDL N+L+ + I DFGL+ R E + Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 222 EYVVTRWYRAPELLLN------SSDYTAAIDVWSVGCIFMELMDRKP-LFPGRDHVH-QL 273 V T Y APE+L +D++++G I+ E+ R LFPG Q+ Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQM 246 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 E+ P+ E+++ L K+ + + S+ + + IE D Sbjct: 247 AFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVR------SLKETIEDCWDQDA 300 Query: 334 RRRITVL 340 R+T Sbjct: 301 EARLTAQ 307 >5AR8-A nrPDB Length = 326 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 115/299 (38%), Gaps = 30/299 (10%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHEN 121 + + +GA G V SA +++ VA+K + + + K LRE ++L Sbjct: 34 LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSY 93 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSNQALS---EEHCQYFLYQILRGL 177 I+ I I P I E M + L++++ L++I G+ Sbjct: 94 ILPILGICNEPEFLG-----IVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 178 KYIHSAN--VLHRDLKPSNLLLNANCDLKICDFGLARV------TSESDFMTEYVVTRWY 229 Y+H+ +LH DLK N+LL+ +KI DFGL++ S S T Y Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 208 Query: 230 RAPELLL--NSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 287 PE S + D++S I E++ RK F + Q ++ + S+ Sbjct: 209 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQ------IMYSVSQGH 262 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR----ITVLDA 342 +NE + Y I + ++ ++ +P R IT L+A Sbjct: 263 RPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEA 321 >2QKW-B nrPDB Length = 321 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 113/283 (39%), Gaps = 30/283 (10%) Query: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 IG G +G V + + VA+K+ ++ + EI+ L H ++V++ Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALKR--RTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 129 IPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ----ALSEEHCQYFLYQILRGLKYIHSA 183 + N++ + Y+ M+ +L + + + ++S E RGL Y+H+ Sbjct: 104 C-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTR 158 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLAR---VTSESDFMTEYVVTRWYRAPELLLNSSD 240 ++HRD+K N+LL+ N KI DFG+++ ++ T T Y PE + Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI-KGR 217 Query: 241 YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIR 300 T DV+S G + E++ + + L + + + +LE + + Sbjct: 218 LTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVD------- 270 Query: 301 QLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 P + + A+ K L R ++ D L Sbjct: 271 --PNLADKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >2Y4I-B nrPDB Length = 319 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 131/322 (40%), Gaps = 40/322 (12%) Query: 41 SHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDN 100 S + Q +IF +++ + IGKG +G V VAI+ I DN Sbjct: 13 SFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDN 69 Query: 101 KIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIR-SN 158 + K RE+ R HEN+V P A I L L+ ++R + Sbjct: 70 EDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLA-----IITSLCKGRTLYSVVRDAK 124 Query: 159 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--- 215 L + +I++G+ Y+H+ +LH+DLK N+ + N + I DFGL ++ Sbjct: 125 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQ 183 Query: 216 ---ESDFMTEYVVTRWYRAPELLLNSS--------DYTAAIDVWSVGCIFMELMDRKPLF 264 D + + APE++ S ++ DV+++G I+ EL R+ F Sbjct: 184 AGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 243 Query: 265 PGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 ++ +GT + L + + I + + ++ PT L +D+ Sbjct: 244 K----TQPAEAIIWQMGTGMKPNLSQIG--MGKEISDILLFCWAFEQEERPTFTKL-MDM 296 Query: 325 IEKMLTFDPRRRITVLDALAHP 346 +EK+ + RR++ HP Sbjct: 297 LEKLPKRN--RRLS------HP 310 >4F9B-A nrPDB Length = 361 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 75/344 (21%), Positives = 131/344 (38%), Gaps = 70/344 (20%) Query: 68 PIGKGAYGIVCSAM---NSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIV 123 IG+G + V A E +A+K + R E++ L +N++ Sbjct: 28 KIGEGTFSSVYLATAQLQVGPEEKIALKHL----IPTSHPIRIAAELQCLTVAGGQDNVM 83 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 ++ + V IA ++ + + +LS + + ++ + + LK IH Sbjct: 84 GVKYCF-----RKNDHVVIAMPYLEHE--SFLDILNSLSFQEVREYMLNLFKALKRIHQF 136 Query: 184 NVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSES------------------------- 217 ++HRD+KPSN L N + DFGLA+ T ++ Sbjct: 137 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSIC 196 Query: 218 ----DFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFP-GRDHVHQ 272 + T +RAPE+L + T AID+WS G IF+ L+ + F D + Sbjct: 197 LSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTA 256 Query: 273 LRLLMELIGT-------------------PSEEELEFLNENAKRYIRQLPPYPRQ----- 308 L +M + G+ ++L L E + P Sbjct: 257 LAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHA 316 Query: 309 SITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLH 352 + + + V A DL++K+L +P RIT +AL HP+ + Sbjct: 317 TNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >2H34-A nrPDB Length = 309 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 97/226 (42%), Gaps = 10/226 (4%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD-NKIDAKRTLREIKLLRHMDHEN 121 +G+G G V A ++ VA+K ++ + + R RE + + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYI 180 +V I D +Y+ L++ DL ++R L+ + QI L Sbjct: 96 VVPIHDFGEID-----GQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAA 150 Query: 181 HSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTEYVVTRWYRAPELLLNS 238 H+A HRD+KP N+L++A+ + DFG+A T++ + V T +Y APE + Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSE 209 Query: 239 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 S T D++++ C+ E + P + G + + I PS Sbjct: 210 SHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >2QLU-A nrPDB Length = 314 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 113/288 (39%), Gaps = 33/288 (11%) Query: 71 KGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIP 130 +G +G V A N+ VA+K ++ REI M HEN++ Sbjct: 25 RGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSE---REIFSTPGMKHENLLQFIAA-E 78 Query: 131 PPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS------- 182 N ++++ D L ++ N ++ + + RGL Y+H Sbjct: 79 KRGSNLEVELWLITAFHDKGSLTDYLKGN-IITWNELCHVAETMSRGLSYLHEDVPWCRG 137 Query: 183 ----ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE---YVVTRWYRAPELL 235 ++ HRD K N+LL ++ + DFGLA + V TR Y APE+L Sbjct: 138 EGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 236 LNSSDYTA----AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 + ++ ID++++G + EL+ R G + L E+ PS EEL+ Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQ-- 255 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 + + P + K P + L + IE+ D R++ Sbjct: 256 --EVVVHKKMRPTIKDHWL--KHPGLAQLCVT-IEECWDHDAEARLSA 298 >3LMG-A nrPDB Length = 344 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 90/226 (39%), Gaps = 18/226 (7%) Query: 50 NIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR 109 + IF+ T + +G G +G V + ES+ I ++K + Sbjct: 22 KVLARIFKETE--LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQA 79 Query: 110 EIKLL---RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQA-LSEE 164 + +DH +IV + + P + + + + L +R ++ L + Sbjct: 80 VTDHMLAIGSLDHAHIVRLLGLCPGSS------LQLVTQYLPLGSLLDHVRQHRGALGPQ 133 Query: 165 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDF--MTE 222 + QI +G+ Y+ ++HR+L N+LL + +++ DFG+A + D + Sbjct: 134 LLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYS 193 Query: 223 YVVTRW-YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPG 266 T + A E + + YT DVWS G ELM + G Sbjct: 194 EAKTPIKWMALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAG 238 >5VC6-A nrPDB Length = 289 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 107/300 (35%), Gaps = 55/300 (18%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 124 + IG G +G V + AIK+ +D + LRE+ + H ++V Sbjct: 16 LEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR 75 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 184 + Y + + + R E + L Q+ RGL+YIHS + Sbjct: 76 YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMS 135 Query: 185 VLHRDLKPSNLLLNANC-------------------DLKICDFGLARVTSESDFMTEYVV 225 ++H D+KPSN+ ++ KI D G VT S E Sbjct: 136 LVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG--HVTRISSPQVEEGD 193 Query: 226 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 285 +R + A E+L + + D++++ + +PL D H++R Sbjct: 194 SR-FLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQ---------- 242 Query: 286 EELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 345 +LP P+ + +L++ M+ DP RR + + + H Sbjct: 243 --------------GRLPRIPQV--------LSQEFTELLKVMIHPDPERRPSAMALVKH 280 >5VDK-A nrPDB Length = 297 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 53/305 (17%), Positives = 94/305 (30%), Gaps = 59/305 (19%) Query: 60 AKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-D 118 K + IG G +G V + AIK+ F + L E+ + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 119 HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLK 178 H ++V + Y + + + +S E + L QI GL Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 179 YIHSANVLHRDLKPSNL-----------------------LLNANCDLKICDFGLARVTS 215 YIH+++++H D+KPSN+ L+AN KI D G A + Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 216 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRL 275 + A E+L + D++++G + L H +R Sbjct: 194 ---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRK 250 Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 P P++ + L++ M+ D + Sbjct: 251 ------------------------GNFPDVPQE--------LSESFSSLLKNMIQPDAEQ 278 Query: 336 RITVL 340 R + Sbjct: 279 RPSAA 283 >5J0A-A nrPDB Length = 300 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 118/305 (38%), Gaps = 42/305 (13%) Query: 64 PPIMPIGKGAYGI---VCSAMNSETNESV---AIKKIA---NAFDNKIDAKRTLREIKLL 114 P + +G +G V S S A+KKI N + KR + E K+L Sbjct: 12 PFMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKIL 68 Query: 115 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIR-----SNQALSEEHCQY 168 + + H NIV R + +A E L+ +I S Sbjct: 69 KSLHHPNIVGYRAF----TEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILK 124 Query: 169 FLYQILRGLKYIHS-ANVLHRDLKPSNLLLNANCD-LKICDFGLARVTSESDFMTE---- 222 + RGLKY+H +LH D+K SN+++ + + +KICD G++ E+ +T+ Sbjct: 125 VALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEAC 184 Query: 223 YVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT 282 Y+ T ++ E + + T D+++ G E+M H + Sbjct: 185 YIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-------HINLSNDDDDED 237 Query: 283 PSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-- 340 + +E +F +E + PP + + + + V I+L DP+ R + Sbjct: 238 KTFDESDFDDEAYYAALGTRPPINMEELDESYQKV----IELFSVCTNEDPKDRPSAAHI 293 Query: 341 -DALA 344 +AL Sbjct: 294 VEALE 298 >6BFN-A nrPDB Length = 342 Score = 150 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 49/208 (23%), Positives = 84/208 (40%), Gaps = 17/208 (8%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA--KRTLREIKLLRHMDHENIVAI 125 IG+G +G V A+ T A+K++ D + A + L E++ L H NIV Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH--SA 183 ++ ++ LH ++ LS L R ++++H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 184 NVLHRDLKPSNLLLNANCDLKICDFGLAR----------VTSESDFMTEYVVTRWYRAPE 233 +++H D+K SN+LL+ K+ DFGLAR +S T Y PE Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PE 205 Query: 234 LLLNSSDYTAAIDVWSVGCIFMELMDRK 261 + + D +S G + +E + + Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5L2Q-C nrPDB Length = 320 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 100/303 (33%), Gaps = 64/303 (21%) Query: 78 CSAMNSETNESVAIKKIA---------NAFDNKIDAKRTLREIKLLRHMD------HEN- 121 C A T++ +K + + + + E LL + H + Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 122 --------IVAIRDIIPPPLRNAFNDVYIAYELMDTD----------LHQIIRSNQALSE 163 IV + + + L D L + + LSE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 164 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-LKICDFGLARVT-SESDFMT 221 Y ++R ++ +H N++HRDLK N++LN + I +F L + SE D + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 + + Y +P++L D+W++G + ++ + F R + Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 341 T E+ V + LI K+L DP++R+ D Sbjct: 273 TIPED----------------------------GRVSENTVCLIRKLLVLDPQQRLAAAD 304 Query: 342 ALA 344 L Sbjct: 305 VLE 307 >5E8V-A nrPDB Length = 316 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 111/298 (37%), Gaps = 41/298 (13%) Query: 69 IGKGAYGIVCSAMNSETN----ESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIV 123 +GKG + V A + E+VA+K + + K +I ++ HENI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLKHENIL 72 Query: 124 AIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS- 182 I +L + + + +S E + + RG+ ++HS Sbjct: 73 QFLTAEERKTELGKQYWLITAFHAKGNLQEYL-TRHVISWEDLRKLGSSLARGIAHLHSD 131 Query: 183 --------ANVLHRDLKPSNLLLNANCDLKICDFGLA-----RVTSESDFMTEYVVTRWY 229 ++HRDLK SN+L+ + +CDFGL+ ++ + + V T Y Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARY 191 Query: 230 RAPELL-----LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 APE+L L + + DV+S+ + E+ R + V +++ G+ Sbjct: 192 MAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC------NAVGEVKDYEPPFGSKV 245 Query: 285 EEELEFLNENAKRYIRQ--LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 E + A + P P + + + + + DP R+T Sbjct: 246 REH-PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET---LTECWDHDPEARLTAQ 299 >4LQP-A nrPDB Length = 508 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 41/194 (21%), Positives = 84/194 (43%), Gaps = 10/194 (5%) Query: 34 ENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKK 93 E LS G+ + ++ + + IGKGA+G V +T + A+K Sbjct: 75 ERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKT 134 Query: 94 IANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDL 151 + + K D E +L D +V++ +Y+ E + DL Sbjct: 135 LLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDA-----QYLYLIMEFLPGGDL 189 Query: 152 HQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLA 211 ++ Q +E+ ++++ + + ++ IH +HR +KP N+L++ +K+ DFGL+ Sbjct: 190 MTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Query: 212 ---RVTSESDFMTE 222 T +S++ + Sbjct: 250 TGFHKTHDSNYYKK 263 Score = 89.7 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 30/134 (22%), Positives = 47/134 (35%), Gaps = 32/134 (23%) Query: 222 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 281 V T Y APE+ L Y D WS+G I E + P F R +M Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNF-- 378 Query: 282 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI---- 337 E+ L+F ++ + A DLI ++LT +R+ Sbjct: 379 ---EQTLQFPDDI---------------------HISYEAEDLIRRLLTH-ADQRLGRHG 413 Query: 338 TVLDALAHPYLNSL 351 + +HP+ + Sbjct: 414 GADEIKSHPFFRGV 427 >4M69-B nrPDB Length = 283 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 96/279 (34%), Gaps = 40/279 (14%) Query: 75 GIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIRDIIPPP 132 + + V IK N + R EIK ++ D NI+ I I Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 133 LRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLK 191 + I E + L +++ + L+ + + RGL +H + LHR++ Sbjct: 81 TV-KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 139 Query: 192 PSNLLLNANCDLKICDFGLARVTSE-----SDFMTEYVVTRWYRAPELLLN-SSDYTAAI 245 S+ L+ +K+ F L++ + E + Y +PE L N Y Sbjct: 140 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 199 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 +++S G + E+ K F G D + + EL+ ++E Sbjct: 200 EIYSFGIVLWEIATGKIPFEGCDS----KKIRELVAEDKKQE------------------ 237 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 L ++I + +P +R +V L Sbjct: 238 ------PVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 96/279 (34%), Gaps = 40/279 (14%) Query: 75 GIVCSAMNSETNESVAIKKIANAFDNKIDAKRTL--REIKLLRHMDHENIVAIRDIIPPP 132 + + V IK N + R EIK ++ D NI+ I I Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 133 LRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLK 191 + I E + L +++ + L+ + + RGL +H + LHR++ Sbjct: 267 TV-KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 325 Query: 192 PSNLLLNANCDLKICDFGLARVTSE-----SDFMTEYVVTRWYRAPELLLN-SSDYTAAI 245 S+ L+ +K+ F L++ + E + Y +PE L N Y Sbjct: 326 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 385 Query: 246 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 305 +++S G + E+ K F G D + + EL+ ++E Sbjct: 386 EIYSFGIVLWEIATGKIPFEGCDS----KKIRELVAEDKKQE------------------ 423 Query: 306 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 L ++I + +P +R +V L Sbjct: 424 ------PVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4JRN-A nrPDB Length = 372 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 109/310 (35%), Gaps = 72/310 (23%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK-RTLREIKLLRHMD-------- 118 P+G G + V A + ETNE +A+K + + + RE R+ Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 119 --------HENIVAIRD------IIPPPLRNAFNDVYIAYELMDTDLHQIIR-------- 156 ++V + ++ + ++ + D+ ++I Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 157 SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSE 216 + Y Q ++ + + + ++H D+KP+N LL + L + DFG R+ Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI--- 251 Query: 217 SDFMTEYVVTRWYRAPELLLNSSD--YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 274 ++ + + T Y PE ++ YT D W +G + ++ Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP----------- 300 Query: 275 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 334 TP++ ++L+ P+ L DLI +L DP+ Sbjct: 301 -------TPADGIWDYLH------------------FADCPSTPELVQDLIRSLLNRDPQ 335 Query: 335 RRITVLDALA 344 +R+ L AL Sbjct: 336 KRMLPLQALE 345 >4MWI-A nrPDB Length = 294 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 104/308 (33%), Gaps = 52/308 (16%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID--AK 105 + + G+ + + + + + KG Y A VAIK I + Sbjct: 21 KEQLSGSPWILLRE--NEVSTLYKGEY---HRA-------PVAIKVFKKLQAGSIAIVRQ 68 Query: 106 RTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEE 164 +EIK ++ + NI+ I I I E + L +++ + L+ Sbjct: 69 TFNKEIKTMKKFESPNILRIFGICIDETVTPPQ-FSIVMEYCELGTLRELLDREKDLTLG 127 Query: 165 HCQYFLYQILRGLKYIHSANV--LHRDLKPSNLLLNANCDLKICDFGLARV-----TSES 217 + RGL +H + LH ++ SN L+ +K+ F L + + Sbjct: 128 KRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTT 187 Query: 218 DFMTEYVVTRWYRAPELLLN-SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLL 276 T+ V + Y +P+ L + Y +++S G + E+ F G + + Sbjct: 188 REKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSE----KI 243 Query: 277 MELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 +L+ ++E ++I++ DP R Sbjct: 244 RKLVAVKRQQE------------------------PLGEDCPSELREIIDECRAHDPSVR 279 Query: 337 ITVLDALA 344 +V + L Sbjct: 280 PSVDEILK 287 >3HNG-A nrPDB Length = 360 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 43/191 (22%), Positives = 75/191 (39%), Gaps = 33/191 (17%) Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES 217 + ++ E + +Q+ RG++++ S +HRDL N+LL+ N +KICDFGLAR ++ Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 218 DFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQL 273 TR + APE + + Y+ DVWS G + E+ +PG Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDE-- 309 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 +F + + + P Y P ++ DP Sbjct: 310 ---------------DFCSRLREGMRMRAPEYS-----------TPEIYQIMLDCWHRDP 343 Query: 334 RRRITVLDALA 344 + R + + Sbjct: 344 KERPRFAELVE 354 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 52/134 (38%), Gaps = 12/134 (8%) Query: 35 NIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSA-----MNSETNESV 89 ++P + + + + +E + +G+GA+G V A S T +V Sbjct: 1 SMPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTV 60 Query: 90 AIKKIANAFDNKIDAKRTLREIKLLRHMDHE-NIVAIRDIIPPPLRNAFNDVYIAYELMD 148 A+K + + K + E+K+L H+ H N+V + + + E Sbjct: 61 AVKMLKEGATAS-EYKALMTELKILTHIGHHLNVVNLLGACTKQG----GPLMVIVEYCK 115 Query: 149 -TDLHQIIRSNQAL 161 +L ++S + L Sbjct: 116 YGNLSNYLKSKRDL 129 >4BTK-A nrPDB Length = 337 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 114/297 (38%), Gaps = 35/297 (11%) Query: 30 MPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESV 89 + +S GG Q +I + V ++K + IG G +G + AM+ T E+V Sbjct: 28 LAAALKDETNMSGGGE--QADILPANYVVKDRWKV-LKKIGGGGFGEIYEAMDLLTRENV 84 Query: 90 AIKKIANAFDNKIDAKRTLR-EIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELM 147 A+K ++ K+ L+ E+ +L+ + +++ N Y+ +L Sbjct: 85 ALKV-----ESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQ 134 Query: 148 DTDLHQIIRS--NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL----LLNANC 201 +L + RS + QIL ++ IHS LHRD+KPSN L + Sbjct: 135 GRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYR 194 Query: 202 DLKICDFGLARVTSESD-------FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIF 254 + DFGLAR + + + + T Y + N D+WS+ + Sbjct: 195 KCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYML 253 Query: 255 MELMDRKPLFPGRDHVHQLRLLME------LIGTPSEEELEFLNENAKRYIRQLPPY 305 +E + + Q+ ++ E L+ E FL+ A P Y Sbjct: 254 VEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDY 310 >3VHK-A nrPDB Length = 368 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 41/192 (21%), Positives = 70/192 (36%), Gaps = 33/192 (17%) Query: 158 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSES 217 L+ EH + +Q+ +G++++ S +HRDL N+LL+ +KICDFGLAR + Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 253 Query: 218 DFMTEYVVTRW---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQL 273 R + APE + + YT DVWS G + E+ +PG + Sbjct: 254 PDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 312 Query: 274 RLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDP 333 ++ + P + +P Sbjct: 313 CRRLKEGTRMRAPDY----------------------------TTPEMYQTMLDCWHGEP 344 Query: 334 RRRITVLDALAH 345 +R T + + H Sbjct: 345 SQRPTFSELVEH 356 Score = 75.1 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 48/114 (42%), Gaps = 12/114 (10%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSA----MNS-ETNESVAIKKIANAFDNKIDAKRT 107 + +E P+G+GA+G V A ++ T +VA+K + + + + Sbjct: 21 ASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHS-EHRAL 79 Query: 108 LREIKLLRHMDHE-NIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQ 159 + E+K+L H+ H N+V + P + + E +L +RS + Sbjct: 80 MSELKILIHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKR 129 >4NFN-A nrPDB Length = 309 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 113/287 (39%), Gaps = 35/287 (12%) Query: 40 LSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFD 99 +S GG Q +I + V ++K + IG G +G + AM+ T E+VA+K + Sbjct: 3 MSGGGE--QADILPANYVVKDRWKV-LKKIGGGGFGEIYEAMDLLTRENVALKV-----E 54 Query: 100 NKIDAKRTLR-EIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS 157 + K+ L+ E+ +L+ + +++ N Y+ +L +L + RS Sbjct: 55 SAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRS 109 Query: 158 --NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL----LLNANCDLKICDFGLA 211 + QIL ++ IHS LHRD+KPSN L + + DFGLA Sbjct: 110 QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA 169 Query: 212 RVTSESD-------FMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 264 R + + + + T Y + N D+WS+ + +E + + Sbjct: 170 RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPW 228 Query: 265 PGRDHVHQLRLLME------LIGTPSEEELEFLNENAKRYIRQLPPY 305 Q+ ++ E L+ E FL+ A P Y Sbjct: 229 RKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDY 275 >5FQD-C nrPDB Length = 341 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 86/231 (37%), Gaps = 31/231 (13%) Query: 42 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 101 GGR + F V KYK + IG G++G + A+N E VA+K K Sbjct: 1 GGGRMASSSGSKAEFIVGGKYKL-VRKIGSGSFGDIYLAINITNGEEVAVK----LESQK 55 Query: 102 IDAKRTLREIKLLRHMDH----ENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR- 156 + L E KL + + +I + + +L+ L + Sbjct: 56 ARHPQLLYESKLYKILQGGVGIPHI-RWYG-------QEKDYNVLVMDLLGPSLEDLFNF 107 Query: 157 SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLK---ICDFGLARV 213 ++ + + Q++ ++Y+H+ N +HRD+KP N L+ + DFGLA+ Sbjct: 108 CSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKK 167 Query: 214 TSESDFM--------TEYVVTRWYRAPELLLNSSDYTAAIDVWSVG-CIFM 255 ++ T Y + L + D+ S+G + Sbjct: 168 YRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMY 217 >2PZI-A nrPDB Length = 681 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 111/292 (38%), Gaps = 47/292 (16%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE-TNESVAIKKIANAFDNKIDAKRTLREIK 112 N ++ A I G G + A++ V +K + ++ D + A + Sbjct: 73 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-Q 131 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 L + H +IV I + + R+ YI E + + Q L +L + Sbjct: 132 FLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR-SKGQKLPVAEAIAYLLE 190 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG-LARVTSESDFMTEYVVTRWYRA 231 IL L Y+HS +++ DLKP N++L LK+ D G ++R+ S T ++A Sbjct: 191 ILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQA 245 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE++ T A D+++VG L P GR + G P ++ + Sbjct: 246 PEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKT 293 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 ++ R L+ + + DPR+R T + + Sbjct: 294 YDSYGR--------------------------LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 111/292 (38%), Gaps = 47/292 (16%) Query: 54 NIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE-TNESVAIKKIANAFDNKIDAKRTLREIK 112 N ++ A I G G + A++ V +K + ++ D + A + Sbjct: 112 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-Q 170 Query: 113 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 L + H +IV I + + R+ YI E + + Q L +L + Sbjct: 171 FLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR-SKGQKLPVAEAIAYLLE 229 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG-LARVTSESDFMTEYVVTRWYRA 231 IL L Y+HS +++ DLKP N++L LK+ D G ++R+ S T ++A Sbjct: 230 ILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQA 284 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 PE++ T A D+++VG L P GR + G P ++ + Sbjct: 285 PEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGR----------YVDGLPEDDPVLKT 332 Query: 292 NENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 343 ++ R L+ + + DPR+R T + + Sbjct: 333 YDSYGR--------------------------LLRRAIDPDPRQRFTTAEEM 358 >4RT7-A nrPDB Length = 415 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 86/235 (36%), Gaps = 45/235 (19%) Query: 109 REIKLLRHMDHENIVAIRD-IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQ 167 RE+++ H D + I + + + E + DL+ L+ E Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEIEYENQKRLEE--EEDLN-------VLTFEDLL 246 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTR 227 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR R Sbjct: 247 CFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 228 W---YRAPELLLNSSDYTAAIDVWSVGCIFMELMD-RKPLFPGRDHVHQLRLLMELIGTP 283 + APE L YT DVWS G + E+ +PG P Sbjct: 307 LPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG---------------IP 350 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRIT 338 + L +N + + I +++ FD R+R + Sbjct: 351 VDANFYKLIQNGFKMDQPFYATEEIYI-------------IMQSCWAFDSRKRPS 392 Score = 82.4 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 53/122 (43%), Gaps = 16/122 (13%) Query: 45 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMN---SETNE--SVAIKKIANAFD 99 R +Y++ +E + +G GA+G V +A S+T VA+K + D Sbjct: 52 REYEYDL---KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKAD 108 Query: 100 NKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYEL-MDTDLHQIIRS 157 + + + + E+K++ + HENIV + +Y+ +E DL +RS Sbjct: 109 SS-EREALMSELKMMTQLGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRS 162 Query: 158 NQ 159 + Sbjct: 163 KR 164 >3SV0-A nrPDB Length = 483 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 97/277 (35%), Gaps = 32/277 (11%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH----ENI 122 IG G++G + N +TNE VAIK + K + L E K+ R + N Sbjct: 13 RKIGSGSFGEIYLGTNIQTNEEVAIK----LENVKTKHPQLLYESKIYRILQGGTGIPN- 67 Query: 123 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIH 181 V + + + +L+ L + ++ LS + Q++ ++++H Sbjct: 68 VRWFGV-------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVH 120 Query: 182 SANVLHRDLKPSNLLLN---ANCDLKICDFGLARVTSESDFM--------TEYVVTRWYR 230 S + LHRD+KP N L+ + I DFGLA+ ++ T Y Sbjct: 121 SKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYA 180 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPG---RDHVHQLRLLMELIGTPSEEE 287 + L + D+ S+G + M + + G + + E S E Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEA 239 Query: 288 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 L R + + L DL Sbjct: 240 LCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDL 276 >5USZ-A nrPDB Length = 289 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 47/291 (16%), Positives = 100/291 (34%), Gaps = 31/291 (10%) Query: 56 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE-------SVAIKKIANAFDNKIDAKRTL 108 ++ + +G+G + + + E + V +K + A N ++ Sbjct: 3 HKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFF 60 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQ 167 ++ + H+++V + N ++ + L ++ N+ ++ Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKF----GSLDTYLKKNKNCINILWKL 116 Query: 168 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD--------LKICDFGLARVTSESDF 219 Q+ + ++ ++H ++ N+LL D +K+ D G++ D Sbjct: 117 EVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI 176 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLME 278 + E + + PE + N + A D WS G E+ D +L+ + Sbjct: 177 LQERIP---WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED 233 Query: 279 --LIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 + P EL L N Y P R I D P DL+ + Sbjct: 234 RHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTP---DLVPR 281 >4L68-A nrPDB Length = 340 Score = 118 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 100/261 (38%), Gaps = 35/261 (13%) Query: 75 GIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLR 134 G A+ ++A+K ++ K+ + E+ L + H N+ + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTC---KLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEE 109 Query: 135 NAFNDVYIAYELM-DTDLHQIIRSNQA-LSEEHCQYFLYQILRGLKYIHSAN---VLHRD 189 ++ Y+ M + LH ++ SN+ L RGL ++H +LH++ Sbjct: 110 K-----FLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQN 164 Query: 190 LKPSNLLLNANCDLKICDFGLARVT-----SESDFMTEYVVTRWYRAPELLLNSSDYTAA 244 + S +L++ + D +I D GLAR+ +ES FMT + Y APE + + Sbjct: 165 ICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLK 223 Query: 245 IDVWSVGCIFMELMDRKPL-----FPGR--DHVHQLR--------LLMELIGTPSEEELE 289 DV+ +G + +EL F G D V QL + G +EE+ Sbjct: 224 GDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEIS 283 Query: 290 FLNENAKRYIRQLPPYPRQSI 310 E A + P Sbjct: 284 KFVEIALNCVSSRPKERWSMF 304 >4TN6-A nrPDB Length = 318 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 95/288 (32%), Gaps = 25/288 (8%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 V +Y+ IG G++G + + E VAIK K + E K+ + Sbjct: 4 RVGNRYRLG-RKIGSGSFGDIYLGTDIAAGEEVAIK----LECVKTKHPQLHIESKIYKM 58 Query: 117 MDHENIVAIRDIIPPPLRNAFNDV-YIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQIL 174 M I A D + EL+ L + ++ S + Q++ Sbjct: 59 MQ-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMI 113 Query: 175 RGLKYIHSANVLHRDLKPSNLLLN---ANCDLKICDFGLARVTSESDFM--------TEY 223 ++YIHS N +HRD+KP N L+ + I DFGLA+ ++ Sbjct: 114 SRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNL 173 Query: 224 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 283 T Y + L + D+ S+G + M + G + + + Sbjct: 174 TGTARYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKK 232 Query: 284 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 +E L + + R D P L L + Sbjct: 233 MSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYL-RQLFRNLFHR 279 >4L00-A nrPDB Length = 304 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 52/324 (16%), Positives = 104/324 (32%), Gaps = 64/324 (19%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAM------NSETNESVAIKKIANAFDNKID--AKRTL 108 + K +G+G + S + T+E IK I D + Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 109 REIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQII--RSNQALSEEHC 166 ++R + H++IV + + + N + E ++ + R + L+ Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENI-----MVEEFVEGGPLDLFMHRKSDVLTTPWK 135 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-------LKICDFGLARVTSESDF 219 Q+ L Y+ +++H ++ NLLL +K+ D G+ Sbjct: 136 FKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQE 195 Query: 220 MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMEL 279 E + + APE + +S + + A D WS G E+ Sbjct: 196 CIERIP---WIAPECVEDSKNLSVAADKWSFGTTLWEICY-------------------- 232 Query: 280 IGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV 339 G ++ + + R P P DL+ + + +DP +R Sbjct: 233 NGEIPLKDKTLIEKERFYESRCRPVTP----------SCKELADLMTRCMNYDPNQR--- 279 Query: 340 LDALAHPYLNSLHDISDEPECTIP 363 P+ ++ ++ E P Sbjct: 280 ------PFFRAIMRDINKLEEQNP 297 >5X1R-A nrPDB Length = 302 Score = 110 bits (276), Expect = 8e-25, Method: Composition-based stats. Identities = 52/306 (16%), Positives = 103/306 (33%), Gaps = 49/306 (16%) Query: 49 YNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID----- 103 N FE+ IG+G +GIV A + + ++AIK+ K + Sbjct: 16 SGYRFNEFEIQE-------AIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSI 68 Query: 104 --------------AKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT 149 ++E +LL H ++ + Y+ + Sbjct: 69 GLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEEN-----GTAYMGTQFYSG 123 Query: 150 DLHQIIRSNQA--LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICD 207 + +++ Q + E + L + + IH LHRD+ N+ + + + D Sbjct: 124 TTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLD 183 Query: 208 FGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSD--YTAAIDVWSVGCIFMELMDRKPLF 264 FG AR TE V+ + E +SD D++++G + L+ P Sbjct: 184 FGSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP 243 Query: 265 PGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDL 324 + ++ + + Y +L +++ K P P ID Sbjct: 244 ------------VSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALK-PEDRPQTIDE 290 Query: 325 IEKMLT 330 + ++L Sbjct: 291 MAELLE 296 >2CMW-A nrPDB Length = 310 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 29/280 (10%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH--ENIVA 124 IG G +G + N TNE VAIK K A + E + + + E + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIK----LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSA 183 + P NA + EL+ L + ++ + + Q+L ++Y+HS Sbjct: 62 VYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 184 NVLHRDLKPSNLLLNANCDLK-----ICDFGLARVTSESDF--------MTEYVVTRWYR 230 N+++RD+KP N L+ + K I DFGLA+ + + T Y Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 + L + D+ ++G +FM + + G ++ T +E Sbjct: 177 SINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEA 235 Query: 291 LNENAKRYIRQLPPYPRQ---SITDKFPTVHPLAIDLIEK 327 L EN + Y R+ + + L DL EK Sbjct: 236 LCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >5UV4-A nrPDB Length = 311 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 58/237 (24%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 39 TLSHGGRFIQYNIFGNIFEVTAKYKP--PIMPIGKGAYGIVCSAMNSETNESVAIKKIAN 96 ++S ++F N TA+ P IG+ +G A + + +K + Sbjct: 1 SMSPDKLVGDLHLFDNSVVFTAEELSCAPAEIIGRSCHGTSYKAT-LDNGYMLTVKWLKE 59 Query: 97 AFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQII 155 F K REIK L + H N+V +R P + + + D T L + Sbjct: 60 GFAKS--KKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERI---MISDYADATSLSTYL 114 Query: 156 -----RSNQALSEEHCQYFLYQILRGLKYIHSANVL-HRDLKPSNLLL-NANCDLKICDF 208 R+ LS I R L Y+H+ V+ H ++K SN+L+ N+ + D+ Sbjct: 115 SEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDY 174 Query: 209 GLARVTSESDFMTEYV---VTRWYRAPELLLNSSDY-TAAIDVWSVGCIFMELMDRK 261 L R+ + M E V Y PE S + DV++ G I +EL+ K Sbjct: 175 SLHRLMTPIG-MAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >2CHL-A nrPDB Length = 351 Score = 108 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 103/278 (37%), Gaps = 27/278 (9%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDH-ENIVAI 125 IG G +G + N TNE VAIK K A + E + + + + I + Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIK----LEPMKSRAPQLHLEYRFYKQLGSGDGIPQV 91 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSAN 184 P NA + EL+ L + ++ S + Q++ ++Y+HS N Sbjct: 92 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 185 VLHRDLKPSNLLLNANCD-----LKICDFGLARVTSESDF--------MTEYVVTRWYRA 231 +++RD+KP N L+ + + I DF LA+ + + T Y + Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMS 206 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 L + D+ ++G +FM + + G ++ T +E L Sbjct: 207 INTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 265 Query: 292 NENAKRYIRQLPPYPRQSITDK--FPTVHPLAIDLIEK 327 EN L R +K + + L DL ++ Sbjct: 266 CENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >5X18-A nrPDB Length = 295 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 43/280 (15%), Positives = 95/280 (33%), Gaps = 25/280 (8%) Query: 62 YKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HE 120 + IG+G++G++ N VAIK K +A + E K + ++ Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILNGTP 63 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKY 179 NI L N + +L+ L + + S + Q++ ++ Sbjct: 64 NIPYAYYFGQEGLHNI-----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIED 118 Query: 180 IHSANVLHRDLKPSNLLLNANCD-----LKICDFGLARVTSESDF--------MTEYVVT 226 +H+ ++++RD+KP N L+ + + DFG+A+ + T Sbjct: 119 LHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGT 178 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 Y + L + D+ ++G +F + + G + + ++ Sbjct: 179 ARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRST 237 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIE 326 + L + + R ++ P L+ Sbjct: 238 NVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLS 277 >5M07-A nrPDB Length = 276 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 43/209 (20%), Positives = 79/209 (37%), Gaps = 27/209 (12%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHEN 121 + +G A G V + A+K ++ A + +R RE ++ + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 122 IVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGLK 178 I+ + D ++IA + +D D Q + R L + + L Sbjct: 92 ILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 179 YIHSANVLHRDLKPSNLLLNA----NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 Y H +LHRD+ P+N++L + + + + DFG+A Y APE Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPE- 192 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPL 263 L +D D +++ + L P Sbjct: 193 LSAGADVDGRADQYALALTAIHLFAGAPP 221 >3REP-A nrPDB Length = 271 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 39/288 (13%), Positives = 88/288 (30%), Gaps = 46/288 (15%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM 117 + K + + + G + + V K + + ++ E LR Sbjct: 7 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVV--KVLKVRDWSTRKSRDFNEECPRLRIF 64 Query: 118 DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL--SEEHCQYFLYQILR 175 H N++ + P + L+ ++ + F + R Sbjct: 65 SHPNVLPVLGACQSPPAPHPTLITHWMPY--GSLYNVLHEGTNFVVDQSQAVKFALDMAR 122 Query: 176 GLKYIHSAN-VLHR-DLKPSNLLLNANCDLKI--CDFGLARVTSESDFMTEYVVTRWYRA 231 G+ ++H+ ++ R L +++++ + +I D + S + A Sbjct: 123 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-FQSPGRMYA-----PAWVA 176 Query: 232 PELLLNSSDYT--AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 289 PE L + T + D+WS + EL+ R+ F ++ + P+ Sbjct: 177 PEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP--- 233 Query: 290 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 P + P L++ + DP +R Sbjct: 234 -------------------------PGISPHVSKLMKICMNEDPAKRP 256 >2C47-A nrPDB Length = 313 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 103/279 (36%), Gaps = 28/279 (10%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAI 125 IG G +G + N TNE VAIK K A + E + + + E + + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIK----LEPIKSRAPQLHLEYRFYKQLSATEGVPQV 65 Query: 126 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKYIHSAN 184 P NA + EL+ L + ++ + + Q++ ++Y+H+ + Sbjct: 66 YYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKS 120 Query: 185 VLHRDLKPSNLLLNANCD-----LKICDFGLARVTSESDF--------MTEYVVTRWYRA 231 +++RD+KP N L+ + I DFGLA+ + + T Y + Sbjct: 121 LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 180 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL 291 L + D+ ++G +FM + + G ++ T +E L Sbjct: 181 INTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL 239 Query: 292 NENAKRYIRQLPPYPRQ---SITDKFPTVHPLAIDLIEK 327 EN + Y R+ + + L DL ++ Sbjct: 240 CENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 278 >5OAT-A nrPDB Length = 411 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 63/342 (18%), Positives = 111/342 (32%), Gaps = 93/342 (27%) Query: 58 VTAKYKPPIMPIGKGAYGIVC--SAMNSETNES---VAIKKIANAFDNKIDAKRTLR--- 109 +T PI KG G+V + ET+++ A+K + N +D + ++ L+ Sbjct: 8 ITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFN-YDIQENSMEILKAMY 66 Query: 110 ------------------EIKLLRHMDH----ENIVAIRDIIP------------PPLRN 135 EI+L H NIVAI + P Sbjct: 67 RETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEG 126 Query: 136 AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNL 195 +++ + D +L + + S L Q+L G+ ++ + + HRDLK NL Sbjct: 127 RNMSLFLLMKRYDCNLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNL 184 Query: 196 LLN----ANCDLKICDFGLARV-------TSESDFMTEYVVTRWYRAPELLLNSSD---- 240 LL+ + L I DFG + + + APE++ Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSV 244 Query: 241 --YTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 298 Y+ D+W+VG I E+ + F G + Sbjct: 245 LNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFN------------------------ 279 Query: 299 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 Y + V + L+ +L +P +R+ Sbjct: 280 ------YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >4NT4-A nrPDB Length = 312 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 54/284 (19%), Positives = 98/284 (34%), Gaps = 34/284 (11%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DH-----E 120 IG G +G + N NE VAIK K A + E + + + H + Sbjct: 18 KKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLLGSHADNAPD 73 Query: 121 NIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILRGLKY 179 I I + R + EL+ L + + S + Q+L ++Y Sbjct: 74 GIPRIYHLGTCGGRYNA----MVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEY 129 Query: 180 IHSANVLHRDLKPSNLLLNANCD-----LKICDFGLARVTSESDF--------MTEYVVT 226 +HS ++++RD+KP N L+ + I DFGLA+ + D T Sbjct: 130 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGT 189 Query: 227 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 Y + + + D+ ++G +FM + + G ++ T Sbjct: 190 ARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT 248 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLT 330 +E L + Y R+ + P D + ++ Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLDFFETPD-----YDFLRRLFQ 287 >4I94-A nrPDB Length = 300 Score = 98.2 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 90/263 (34%), Gaps = 34/263 (12%) Query: 76 IVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRN 135 +V E +A+K+ D+++ L E K + + + + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWP--DSRQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 136 AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN-VLHRDLKPSN 194 ++ E + L +Q + I + L+Y S L+ DL Sbjct: 101 LLIAEFMPNETLAKHLFHW--ESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 195 LLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIF 254 +L + + + ++ FGL + + + + + PE L T ++S G + Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYST---NLAFTPPEYLRTGRV-TPESVIYSFGTLL 214 Query: 255 MELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKF 314 ++L+ K + P + +R + S E +F +++ IR Sbjct: 215 LDLLSGKHIPPSH-ALDLIRDRNIQMLMDSGLEGQFSSDDGTELIR-------------- 259 Query: 315 PTVHPLAIDLIEKMLTFDPRRRI 337 L + L ++PR R Sbjct: 260 ---------LASRCLQYEPRERP 273 >6EQI-C nrPDB Length = 433 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 111/341 (32%), Gaps = 97/341 (28%) Query: 67 MPIGKGAYGIVCSAMNSETN-----ESVAIKKIANAFDNKIDA---KRTLRE-------- 110 PI KG +V SA +A+K + N K RE Sbjct: 21 EPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMSYF 80 Query: 111 -------IKLLRHMD-----HENIVAIRDIIPPPLRNAFND------------------- 139 I+ + H NIV + + + + + Sbjct: 81 FNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSGR 140 Query: 140 ---VYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLL 196 +++ + D L + +R + L Q+L + +++ N+ HRDLK N+L Sbjct: 141 NMSLFLVMKRYDCTLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISHRDLKSDNIL 199 Query: 197 LNAN-----CDLKICDFGLARVTSESDFM-------TEYVVTRWYRAPELL-LNSSDYT- 242 ++ + + I DFG ++ + + R APE+ ++ Sbjct: 200 VDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTFSW 259 Query: 243 ---AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 299 D+W+VG I E+ + F ++ ++ L+++ Sbjct: 260 LNYKKSDLWAVGAIAYEIFNIDNPFY-------------------DKTMKLLSKS----- 295 Query: 300 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL 340 Y + + + T+ + +L+ ML+ +R+ Sbjct: 296 -----YKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >1CSN-A nrPDB Length = 298 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 103/299 (34%), Gaps = 33/299 (11%) Query: 48 QYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT 107 Q N+ G ++V + IG+G++G++ N N+ VAIK + DA + Sbjct: 4 QNNVVGVHYKVGRR-------IGEGSFGVIFEGTNLLNNQQVAIKF----EPRRSDAPQL 52 Query: 108 LREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEH 165 E + + + I + L N + +L+ L ++ + S + Sbjct: 53 RDEYRTYKLLAGCTGIPNVYYFGQEGLHN-----VLVIDLLGPSLEDLLDLCGRKFSVKT 107 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-----LKICDFGLARVTSESDF- 219 Q+L ++ IH ++++RD+KP N L+ + + DFG+ + + Sbjct: 108 VAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTK 167 Query: 220 -------MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 T Y + L + D+ ++G +FM + + G Sbjct: 168 QHIPYREKKNLSGTARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATN 226 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 331 + + L L + Y R D P L L K+L Sbjct: 227 KQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYL-QGLFSKVLER 284 >6J6I-B nrPDB Length = 351 Score = 95.5 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 38/193 (19%), Positives = 72/193 (37%), Gaps = 23/193 (11%) Query: 86 NESVAIKKIANAFD--NKIDAKRTLREIKLLRHM-DHENIVAIRDIIPPPLRNAFNDVYI 142 + S IK+ + + K +I L M +H N + + F + Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE-----FPFPVL 135 Query: 143 AYELMDTDLHQ----IIRSNQA--LSEEHCQYFLYQILRGLKYIHS---ANVLHRDLKPS 193 +E + +I + + L +I + Y+H+ ++HRD+KP Sbjct: 136 VFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPM 195 Query: 194 NLLLNANCDLKICDFGLARVTSESDFMTE---YVVTRWYRAPELLLNSSDY-TAAIDVWS 249 ++ L+ N K+ D + E E + T Y P L + + + T DV+S Sbjct: 196 HVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP--LYHKTCFVTEYTDVYS 253 Query: 250 VGCIFMELMDRKP 262 G + ++ KP Sbjct: 254 FGICLLVIITGKP 266 >4XHH-A nrPDB Length = 403 Score = 94.3 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 96/283 (33%), Gaps = 25/283 (8%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 V K++ IG G++G + N + E VAI + + E ++ ++ Sbjct: 4 RVGRKFRIG-RKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYKY 58 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILR 175 + + + +L+ L + ++ S + Q++ Sbjct: 59 LSGGVGIPFIRWFGREGEYNA----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMIC 114 Query: 176 GLKYIHSANVLHRDLKPSNLLLN---ANCDLKICDFGLARVTSESDFM--------TEYV 224 ++YIH + +HRD+KP N L+ + + DFGL++ + + Sbjct: 115 RVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT 174 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 T Y + L + D+ S+G + + + G + + ++ Sbjct: 175 GTARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKL 233 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLA---IDL 324 +E L + Y R D+ P LA DL Sbjct: 234 CISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 >4XHL-A nrPDB Length = 394 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 96/283 (33%), Gaps = 25/283 (8%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 V K++ IG G++G + N + E VAI + + E ++ R+ Sbjct: 4 RVGRKFRIG-RKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYRY 58 Query: 117 MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIR-SNQALSEEHCQYFLYQILR 175 + + + +L+ L + ++ S + Q+ Sbjct: 59 LSGGVGIPFIRWFGREGEYNA----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFC 114 Query: 176 GLKYIHSANVLHRDLKPSNLLLN---ANCDLKICDFGLARVTSESDFM--------TEYV 224 ++YIH + +HRD+KP N L+ + + DFGL++ + + Sbjct: 115 RIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT 174 Query: 225 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPS 284 T Y + L + D+ S+G + + + G + + ++ Sbjct: 175 GTARYASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 Query: 285 EEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLA---IDL 324 +E L ++ Y + D+ P LA DL Sbjct: 234 NVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >5C01-A nrPDB Length = 342 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 55/367 (14%), Positives = 106/367 (28%), Gaps = 82/367 (22%) Query: 12 TEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGK 71 TE G + M G P TL+ + V K + +G+ Sbjct: 17 TENLYFQGAMGETSNLIIMRGARASPRTLNLSQL--------SFHRVDQKEITQLSHLGQ 68 Query: 72 GAYGIVCSAM------------------------NSETNESVAIKKIANAFDNKIDAKRT 107 G V + V +K + + + A Sbjct: 69 GTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA--F 126 Query: 108 LREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQ--IIRSNQALSEEH 165 L+ + H ++ + + N + E ++ + R + Sbjct: 127 YETASLMSQVSHTHLAFVHGVCVRGPENI-----MVTEYVEHGPLDVWLRRERGHVPMAW 181 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLL-------NANCDLKICDFGLARVTSESD 218 Q+ L Y+ + N++H ++ N+LL + +K+ D G+ + Sbjct: 182 KMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSRE 241 Query: 219 FMTEYVVTRWYRAPELLLNS-SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLM 277 E + + APE L + + A+D W G +E+ F G Sbjct: 242 ERVERIP---WLAPECLPGGANSLSTAMDKWGFGATLLEIC-----FDGE---------- 283 Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI 337 P + E+ + +LP P L + LT++P +R Sbjct: 284 ----APLQSRSPSEKEHFYQRQHRLPE-----------PSCPQLATLTSQCLTYEPTQRP 328 Query: 338 TVLDALA 344 + L Sbjct: 329 SFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 92.8 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 87/275 (31%), Gaps = 50/275 (18%) Query: 80 AMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFND 139 + V +K + + + A L+ + H ++ + + N Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENI--- 132 Query: 140 VYIAYELMDTDLHQ--IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 + E ++ + R + Q+ L Y+ + N++H ++ N+LL Sbjct: 133 --MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 190 Query: 198 -------NANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS-SDYTAAIDVWS 249 + +K+ D G+ + E + + APE L + + A+D W Sbjct: 191 ARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKWG 247 Query: 250 VGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQS 309 G +E+ F G P + E+ + +LP Sbjct: 248 FGATLLEIC-----FDGE--------------APLQSRSPSEKEHFYQRQHRLPE----- 283 Query: 310 ITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 P L + LT++P +R + L Sbjct: 284 ------PSCPQLATLTSQCLTYEPTQRPSFRTILR 312 >4IX6-A nrPDB Length = 350 Score = 78.9 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 104/332 (31%), Gaps = 67/332 (20%) Query: 68 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLR-EIKLLRHMDHEN----I 122 P+G G +G V + + V + NA + + A+ L E+ + H+ H N Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTC 81 Query: 123 VAIRDIIPPPLRNAFND--------VYI---------AYELMDTD---LHQIIRSNQALS 162 I ++ +++ LM L + A Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN--CDLKICDFGLARVTSESDFM 220 + + ++L L +H V+HRD+KP+NL+ LK+ D G A + Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 221 TEYVVT-----RWYR-APELLLNSSDYTAAI----------------DVWSVGCIFMELM 258 Y Y A EL L D WS GC+ ++L Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261 Query: 259 DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVH 318 G L + + F E + Y + + Sbjct: 262 V-----VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGW---- 312 Query: 319 PLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 DL ++++ + R + AL+H + ++ Sbjct: 313 ----DLCQRLMEAERDARASCEAALSHAFFDA 340 >5CLR-A nrPDB Length = 451 Score = 76.6 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 66/195 (33%), Gaps = 23/195 (11%) Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 + ++ +K + ++ E L + + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLT---EFTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 138 NDVYIAYELMDTDLHQIIRSNQALSE-----EHCQYFLYQILRGLKYIHSANVLHRDLKP 192 YI + ++ L+ + + +K H ++HRDLKP Sbjct: 148 ---YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 193 SNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL--LLNSSDYTAAIDVWSV 250 N++L+A+ + DFG + +S+ + T Y APEL + ++ D++++ Sbjct: 205 GNIMLDADMQCHLVDFGSS--SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL 262 Query: 251 GCIFMELMDRKPLFP 265 EL + F Sbjct: 263 AYSLDELFN---PFR 274 >5UU1-A nrPDB Length = 324 Score = 75.4 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 38/252 (15%), Positives = 79/252 (31%), Gaps = 41/252 (16%) Query: 39 TLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAM-----NSETNESVAI-- 91 ++ + ++ GN + + IG G +G++ A + V + Sbjct: 1 SMPFPEGKVLDDMEGNQWVLG-------KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEY 53 Query: 92 ----------KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVY 141 K K R + +D+ I + + Sbjct: 54 QENGPLFSELKFYQRVAKKDCIKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYR-F 107 Query: 142 IAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC 201 + E + DL +I N + ++L L+YIH +H D+K +NLLL Sbjct: 108 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 167 Query: 202 --DLKICDFGLA--------RVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVG 251 + + D+GL+ + + + T + + + + DV +G Sbjct: 168 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKG-VALSRRSDVEILG 226 Query: 252 CIFMELMDRKPL 263 + + K Sbjct: 227 YCMLRWLCGKLP 238 >2RSV-A nrPDB Length = 403 Score = 74.7 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 46/227 (20%), Positives = 84/227 (37%), Gaps = 30/227 (13%) Query: 20 GFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCS 79 G ++ P++ + + + Q+ + I ++ K +PIG+G +G + Sbjct: 1 GSSGSSGMPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYL 60 Query: 80 AMNSETNESV------AIKKIANAFDNKIDAKRTLREIKLLRHMDHE---------NIVA 124 A + ++ESV +K D E+K + + Sbjct: 61 A-DMNSSESVGSDAPCVVKV------EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLK 113 Query: 125 IRDI---IPPPLRNAFNDVY--IAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLK 178 + L + Y + + +DL +I +N + S + +IL L+ Sbjct: 114 YLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILE 173 Query: 179 YIHSANVLHRDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEY 223 YIH +H D+K SNLLLN + + D+GLA EY Sbjct: 174 YIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 220 >4CI6-B nrPDB Length = 643 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 97/284 (34%), Gaps = 44/284 (15%) Query: 83 SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-----DHENIVAIRDIIPPPLRNAF 137 + VA + I E++ +H+ H N+ + + P N + Sbjct: 66 KDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRY 119 Query: 138 NDVYIAYELMD-------TDLHQIIRSNQALSEE---HCQYFLYQILRGLKYIHSANVLH 187 + E+ L + + SE ++ +++L ++ A ++H Sbjct: 120 YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVH 179 Query: 188 RDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 246 D+KP N++ + A+ + + D GL + + + T ++APEL + + + D Sbjct: 180 NDIKPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSD 235 Query: 247 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 306 V+ + L+ F + + L + P+ ++EN R Sbjct: 236 VF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAH----VMDENGYPIHRPGIAGV 288 Query: 307 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNS 350 + T I +L R +A H +L+ Sbjct: 289 ETAYTR-----------FITDILGVSADSRPDSNEARLHEFLSD 321 >2LAV-A nrPDB Length = 361 Score = 71.6 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 44/218 (20%), Positives = 84/218 (38%), Gaps = 28/218 (12%) Query: 28 PQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNE 87 P++ + + + Q+ + I ++ K +PIG+G +G + A + ++E Sbjct: 2 PRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSE 60 Query: 88 SV------AIK-------------KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 128 SV +K K ++ +R R + + + Sbjct: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR----TRKLKYLGVPKYWGS 116 Query: 129 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHSANVLH 187 +N + ++ + +DL +I +N + S + +IL L+YIH +H Sbjct: 117 -GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVH 175 Query: 188 RDLKPSNLLLNANC--DLKICDFGLARVTSESDFMTEY 223 D+K SNLLLN + + D+GLA EY Sbjct: 176 GDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 >4O1O-A nrPDB Length = 717 Score = 66.6 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 57/129 (44%), Gaps = 17/129 (13%) Query: 86 NESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIAY 144 ++ VA+K+ + R +E+ L+ ++N+V + + +++ Sbjct: 369 DQEVAVKRFSEGST------RGQQEVSCLQSSRANDNVVTFYGS-----ESDGSCLHVCL 417 Query: 145 ELMDTDLHQIIRSNQA-----LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA 199 L + L + + +++ +E + L + + + +H + H+DL+P N+L+++ Sbjct: 418 ALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDS 477 Query: 200 NCDLKICDF 208 + DF Sbjct: 478 KNGTFLADF 486 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 14/37 (37%), Gaps = 4/37 (10%) Query: 318 HPLAIDLIEKMLTF--DPRRRITVLDALAHPYLNSLH 352 DLI + + R++ LAHP+ S Sbjct: 538 DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWE 572 >4OAU-C nrPDB Length = 699 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 67/191 (35%), Gaps = 25/191 (13%) Query: 25 APSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE 84 P + A L R + I F + KYK + G + Sbjct: 312 PAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADT-----SEGGIYLGFY-- 364 Query: 85 TNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD-HENIVAIRDIIPPPLRNAFNDVYIA 143 + VA+K + R RE+ L+ + ++V + +++ Sbjct: 365 EKQEVAVKTFCEG------SPRAQREVSCLQSSRENSHLVTFYGS-----ESHRGHLFVC 413 Query: 144 YELMDTDLHQIIRSNQALSEEH-----CQYFLYQILRGLKYIH-SANVLHRDLKPSNLLL 197 L + L + ++ E+ + L I + ++ +H S H+DL+P N+L+ Sbjct: 414 VTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 473 Query: 198 NANCDLKICDF 208 ++ + DF Sbjct: 474 DSKKAAHLADF 484 >6G4J-A nrPDB Length = 315 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 47/239 (19%), Positives = 82/239 (34%), Gaps = 33/239 (13%) Query: 63 KPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENI 122 +GKGA GIV A ++ VA+K D+ E+ +L+ Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFS---- 74 Query: 123 VAIRDIIPPPLRNAFNDVYI----------AYELMDTDLHQIIRSNQALSEEHCQYFLYQ 172 + + P +D YI A E + L S++ + Q Sbjct: 75 -KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEW--IPVLMIQ 131 Query: 173 ILRGLKYIHSANVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRA 231 +L L +H + DLKP NL++ ++ D G + R Y Sbjct: 132 LLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGY-- 189 Query: 232 PELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 + + D+++V I + + +K QLR L+E G P ++ + Sbjct: 190 --WGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE--GNPLLQKYKK 244 >5DMZ-A nrPDB Length = 365 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 79/228 (34%), Gaps = 23/228 (10%) Query: 53 GNIFEVTAKYKPPIMPIGKGAYGIVCSAM-----NSETNESVAIKKIANAFDNKIDAKRT 107 F++ +K +G+GA+ V A +++ + +K A + Sbjct: 57 KTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQ 116 Query: 108 LREIKLLRHMDHENIVAIRDI-IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHC 166 L E +L M H + + ++Y L++ + + + Sbjct: 117 LME-RLKPSMQH-MFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 167 QYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD-----------LKICDFGLA---R 212 F ++L ++ +H ++H D+KP N +L L + D G + + Sbjct: 175 ISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMK 234 Query: 213 VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDR 260 + + T T ++ E+L N + ID + V ++ Sbjct: 235 LFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG 281 >6EAS-A nrPDB Length = 308 Score = 65.8 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 31/250 (12%), Positives = 73/250 (29%), Gaps = 41/250 (16%) Query: 100 NKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELM-DTDLHQII--R 156 +K + + ++I L + H+N + + + +E + L + + R Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRV---MVFEYAPNGTLFEHLHVR 137 Query: 157 SNQALSEEHCQYFLYQILRGLKYIHSANV--LHRDLKPSNLLLNANCDLKICDFGLARVT 214 + L I L+++H R+ + + L + K+ D Sbjct: 138 EAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDA 197 Query: 215 SESDFMT--EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 + T E + E ++ G + +E++ + D Sbjct: 198 KGHNSTTNNELAFSPDM---EDIVRK-----------YGMVLLEILTGRVPSSEDDG--- 240 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFD 332 P E + E R + P D + + + + D Sbjct: 241 ----------PLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEV----VRSCIDRD 286 Query: 333 PRRRITVLDA 342 P++R + + Sbjct: 287 PKKRPQMKEV 296 >6M7Z-A nrPDB Length = 319 Score = 63.5 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 79/235 (33%), Gaps = 52/235 (22%) Query: 141 YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 YI + L + ++ + + S Q ++ LK +H+ +LHR ++ ++ + + Sbjct: 123 YIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPD 180 Query: 201 CDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPEL--------LLNSSDYTAAIDVWSVG 251 + + A E+ + APE+ L +T DV+S+G Sbjct: 181 GTVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLG 238 Query: 252 CIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSIT 311 R L++L+G L P R ++ Sbjct: 239 V-------------------AFRNLVQLLGN-----------------GNLGPEDRGAVR 262 Query: 312 DKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNF 366 + L +KM+ +P R T+ + + P L+ E PF + Sbjct: 263 QDHLELLDK---LSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFRY 314 >6EWX-A nrPDB Length = 484 Score = 61.6 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 42/230 (18%), Positives = 69/230 (30%), Gaps = 71/230 (30%) Query: 156 RSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC-------------- 201 R+ + E + L Q+ GL+++ ++HRDL NLLL Sbjct: 202 RAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVP 261 Query: 202 ---------------------------DLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 234 L I +F A+ + ++ APE+ Sbjct: 262 TTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEI 321 Query: 235 LLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN 294 + S D + G + EL+ + F E+ E + Sbjct: 322 VSASQY--RKFDEFQTGILIYELLHQPNPF-------------EVRAQLRERDYRR---- 362 Query: 295 AKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 LPP P S+ P L +L DP +RI + +A Sbjct: 363 -----EDLPPLPTLSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 401 >4CYJ-A nrPDB Length = 438 Score = 60.4 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 29/149 (19%), Positives = 58/149 (38%), Gaps = 21/149 (14%) Query: 74 YGI---VCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIP 130 +G V A NS A++++ + K L +K + + + +IV I ++ Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 131 PPLRNAFNDVYIAYELMDTDLHQIIRSNQ-------------ALSEEHCQYFLYQILRGL 177 F D + + L + ++ + A+ E ++ QI L Sbjct: 123 T---REFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANAL 179 Query: 178 KYIHSANVLHRDLKPSNLLLNANCDLKIC 206 K IHS + R L+PS ++L +++ Sbjct: 180 KTIHSNRLAARCLEPSKIILTDINRIRLS 208 >6BHC-A nrPDB Length = 438 Score = 59.3 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 86/296 (29%), Gaps = 77/296 (26%) Query: 89 VAIKKIANAFDNKID-------AKRTLREIKLLRHMDH-----ENIVAIRDIIPPPLRNA 136 A+K + + + + H N + P + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 137 FNDVYIAYELMDTDLHQIIR-------SNQALSEEHCQYFLYQILRGLKYIHSANVLHRD 189 + V I E+ + +R + L E L Q+ GL+++ +V H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 190 LKPSNLLL---NANCDLKICDFGLARVTSESDFMTEYVVTRWY----------------- 229 L+ NLLL + FG A T S + T +V+ + Sbjct: 204 LRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVS-NFSQAKQKSHLVDPEILRD 260 Query: 230 ---RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 286 APE++ + D + G + E++ F P + Sbjct: 261 QSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFD---------------ENPELK 303 Query: 287 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDA 342 E E+ + R + P L +L +P RI + DA Sbjct: 304 EREYTRADLPRIPFRSP-------------YSRGLQQLASCLLNPNPSERILISDA 346 >5GZ9-A nrPDB Length = 305 Score = 56.9 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 33/214 (15%), Positives = 64/214 (29%), Gaps = 43/214 (20%) Query: 65 PIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 + +G+GA V + E VA+ + + L +++L+ + E++V Sbjct: 38 QLKRVGEGAVKRVFLSEWKE--HKVAL----SRLTRLEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 125 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALS-------EEHCQYFLYQILRGL 177 + I E + LS +H + + + Sbjct: 92 LVGYCEEDGT-------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSII 144 Query: 178 KYIHSANVLHRDLKPSN--------LLLNANCDLKICDFGLARVTSESDFMTEYVVTRW- 228 Y+H + + R + SN LL +N + D + + R Sbjct: 145 NYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHREL 204 Query: 229 ---YRAPELLLNSS-----------DYTAAIDVW 248 + APE L Y +D+W Sbjct: 205 HGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >2JII-A nrPDB Length = 352 Score = 56.6 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 24/206 (11%), Positives = 65/206 (31%), Gaps = 23/206 (11%) Query: 141 YIAYELMDTDLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 198 ++ + L + LSE ++L L+++H +H ++ N+ ++ Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 199 --ANCDLKICDFGLARVTSESDFMTEYV--------VTRWYRAPELLLNSSDYTAAIDVW 248 + + +G A S YV + + +L + D+ Sbjct: 194 PEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQ 252 Query: 249 SVGCIFMELMDRKPLFPG--RDHVHQLRLLMELIGTP-----SEEELEFLNENAKRYIRQ 301 S+G ++ + + + ++ + + P +E ++Y++ Sbjct: 253 SLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKV 312 Query: 302 LPP---YPRQSITDKFPTVHPLAIDL 324 + + + L DL Sbjct: 313 VMALTYEEKPPYAMLRNNLEALLQDL 338 >5GZA-A nrPDB Length = 290 Score = 55.0 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 69/210 (32%), Gaps = 38/210 (18%) Query: 66 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 125 + IG+GA V + + VA+ ++ + A L + +LR + ++V + Sbjct: 30 VKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRALQSSHVVTL 83 Query: 126 RDIIPPP--LRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 183 + ++ + L DT L Q R S + L Y+HS+ Sbjct: 84 VGVCEEDAVFVTEYHPLGSVLTL-DTTLAQE-RYRWRNSWHTRLQLAIDYVAFLAYLHSS 141 Query: 184 --NV--------LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVV----TRWY 229 + LH+ L S LL ++ L D A E + T + Sbjct: 142 PAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDL-DALPEVEKGGLGVKCGHHELTGDF 198 Query: 230 RAPELLLNSS-----------DYTAAIDVW 248 APE L Y D+W Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3ENH-A nrPDB Length = 540 Score = 54.6 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 37/167 (22%), Positives = 70/167 (41%), Gaps = 24/167 (14%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK-KIANAFDNKIDAK-----RTLREIK 112 K K P IGKGA + +S + V IK ++ + ++ + RT RE + Sbjct: 334 GKKRKIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREAR 391 Query: 113 LLRHMDHENIVAIRDIIPPPLRN-AFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLY 171 L +V I P + + ++ I ++ L + + + Y Sbjct: 392 YLA------LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN-------LDIAY 438 Query: 172 QILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 +I + +H +V+H DL SN + + + L I DFGL ++++ + Sbjct: 439 KIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDE 483 >5VE6-A nrPDB Length = 492 Score = 54.6 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 68/234 (29%), Gaps = 83/234 (35%) Query: 163 EEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLK------------------ 204 E + L Q+ GL+++ ++HRDL N LL +C L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLEN-LLLVHCTLQAGPGPAPAPAPAPAAAAP 265 Query: 205 ----------------------------------ICDFGLARVTSESDFMTEYVVTRWYR 230 I +F A+ + ++ Sbjct: 266 PCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARL 325 Query: 231 APELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEF 290 APE++ S D + G + EL+ + F E+ E + Sbjct: 326 APEIVSASQY--RKFDEFQTGILIYELLHQPNPF-------------EVRAQLRERDYR- 369 Query: 291 LNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA 344 LPP P S+ P L +L DP +RI + +A Sbjct: 370 --------QEDLPPLPALSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4AZV-A nrPDB Length = 569 Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 25/136 (18%), Positives = 47/136 (34%), Gaps = 22/136 (16%) Query: 86 NESVAIKK--------IANAFDNKIDAKRTLREIKLLRH----MDHENIVAIRDIIPPPL 133 E K I A +++ + EIK L D ++A Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA--------H 310 Query: 134 RNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPS 193 ++ E + L + + E + L +LR L + H D++P Sbjct: 311 GENAQSGWLVMEKLPGRLLSDMLAAG--EEIDREKILGSLLRSLAALEKQGFWHDDVRPW 368 Query: 194 NLLLNANCDLKICDFG 209 N++++A ++ DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 31/69 (44%), Gaps = 2/69 (2%) Query: 141 YIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN 200 ++ E + L + + E + L +LR L + H D++P N++++A Sbjct: 318 WLVMEKLPGRLLSDMLAAG--EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDAR 375 Query: 201 CDLKICDFG 209 ++ DFG Sbjct: 376 QHARLIDFG 384 >4CZY-B nrPDB Length = 429 Score = 51.6 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 54/140 (38%), Gaps = 14/140 (10%) Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 A N++ A+++I + K L K + + + NIV + + Sbjct: 61 YKAQNNKNGRHFALRRI--EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDS 118 Query: 138 NDVYIA-YELMDTDLHQI----------IRSNQALSEEHCQYFLYQILRGLKYIHSANVL 186 + +++ + + L+ +R+ + E ++ QI L IH+A + Sbjct: 119 SLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLA 178 Query: 187 HRDLKPSNLLLNANCDLKIC 206 R L+ S + + N +++ Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >3BYV-A nrPDB Length = 377 Score = 51.2 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 77/225 (34%), Gaps = 59/225 (26%) Query: 79 SAMNSETNESV--------------AIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 A + ET ES AIK++ ++ R LR IK + V Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMK----EEVLRLRLLRGIKNQKQAK----VH 142 Query: 125 IRDIIPPPL------------RNAFNDVYIA------------YELMDTDLHQIIRSNQA 160 +R I P L R D+++ + L ++++ Sbjct: 143 LRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKS 202 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 L Q++R L +H ++H L+P +++L+ + + F + + + Sbjct: 203 LVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE--HLVRDGARV 260 Query: 221 TEYVVTRWYRAPEL----------LLNSSDYTAAIDVWSVGCIFM 255 V +R + PEL + T + D W++G + Sbjct: 261 VSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIY 304 >3Q60-A nrPDB Length = 371 Score = 50.0 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 58/326 (17%), Positives = 103/326 (31%), Gaps = 55/326 (16%) Query: 59 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREI-----KL 113 + + P+ G +V + E E A+K +N L E +L Sbjct: 60 GERKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARL 119 Query: 114 LRHM-----DHENIVAIRDIIPPPLRNAFNDV-----------YIAY--------ELMDT 149 L D ++ D + + F + Y+ EL+ + Sbjct: 120 LGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFS 179 Query: 150 DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 L + Q++R + S ++H P NL + + L + D Sbjct: 180 TLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDV- 238 Query: 210 LARVTSESDFMTEYVVTRWYRAPELLLNSS--DYTAAIDVWSVGCIFMELMDRKPLFPGR 267 A + V + AP LN+S +T A++ W +G + F Sbjct: 239 SALWKVGTRGPASSVPVTY--APREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF--- 293 Query: 268 DHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 327 + TP + + KR ++P + P + LI + Sbjct: 294 -----------GLVTPG------IKGSWKRPSLRVPGTDSLAFGSCTP-LPDFVKTLIGR 335 Query: 328 MLTFDPRRRITVLDALAHPYLNSLHD 353 L FD RRR+ L+A+ P L + Sbjct: 336 FLNFDRRRRLLPLEAMETPEFLQLQN 361 >4BWP-A nrPDB Length = 448 Score = 49.2 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 52/166 (31%), Gaps = 40/166 (24%) Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 A ++ T + ++ + + + +++ + + H N+V +R++ Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD- 122 Query: 138 NDVYIAYELMDTD---LHQII-----------------------------RSNQALSEEH 165 N + + Y+ L + + L E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 166 CQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNAN----CDLKICD 207 + Q+ GLK IH A + + L P+ +++ I D Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3DZO-A nrPDB Length = 413 Score = 47.3 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 73/224 (32%), Gaps = 58/224 (25%) Query: 79 SAMNSETNESV--------------AIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 124 A + ET ES AIK++ ++ R LR IK + V Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMK----EEVLRLRLLRGIKNQKQAK----VH 147 Query: 125 IRDIIPPPL------------RNAFNDVYIA------------YELMDTDLHQIIRSNQA 160 +R I P L R D+++ + L ++++ Sbjct: 148 LRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKS 207 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFM 220 L Q++R L +H ++H L+P +++L+ + + F + + Sbjct: 208 LVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE--HLVRDGASA 265 Query: 221 TEYVVTRWYRAPELLLNS---------SDYTAAIDVWSVGCIFM 255 + R + PE + T A D W++G Sbjct: 266 VSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIY 308 >4WWA-A nrPDB Length = 261 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 39/178 (21%), Positives = 63/178 (35%), Gaps = 40/178 (22%) Query: 64 PPIMPIGKGAYGIV-------CSAMNSETNESVAIK-----KIANAFDNKIDAK-RTLRE 110 I PI +GA IV ++++ IK + + ++ K RTL E Sbjct: 17 VDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNE 76 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFN-DVYIAYELMDTDL-----------HQIIRSN 158 +LL + I + P L + +I E + DL + Sbjct: 77 SRLLAKLY-----LIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 Query: 159 QALSEE---HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANC---DLKICDFGL 210 S+ + QI GL +H + H DL SN++L + + DFGL Sbjct: 132 DPYSDLVATTLRKVGRQI--GL--LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2W1Z-A nrPDB Length = 368 Score = 45.4 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 91/279 (32%), Gaps = 44/279 (15%) Query: 72 GAYGIVCSAMNSETNE--SV------------AIK---------KIANAFDNKIDAKRTL 108 G+Y I A + ET E V AIK ++ N+ AK L Sbjct: 70 GSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYL 128 Query: 109 R---EIKLLRHMDHENIVAIR----DIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL 161 R I L++ ++ +R D+ + + ++ L ++++L Sbjct: 129 RFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSL 188 Query: 162 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT 221 Q++R + ++H D + N+LL+ + + F + + Sbjct: 189 VHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFE--HLVRDGASAV 246 Query: 222 EYVVTRWYRAPE-----LLLNSSDY----TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQ 272 + R + PE +L + T D W++G + + Sbjct: 247 SPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGG 305 Query: 273 LRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSIT 311 + + + + L E RY ++ P Q++ Sbjct: 306 IEWIYRRCKNIP-QPVRALLEGFLRYSKEDRLLPLQAME 343 >6G38-A nrPDB Length = 357 Score = 44.2 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 29/179 (16%), Positives = 53/179 (29%), Gaps = 43/179 (24%) Query: 58 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA------KRTLREI 111 + + IG+G +G V + T VAIK IA + ++ + L EI Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEI 95 Query: 112 KLLRHM---------DHENIVAIRDI-------------------------IPPPLRNAF 137 + + + E + + + P Sbjct: 96 IISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD 155 Query: 138 NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIH-SANVLHRDLKPSNL 195 + ++I E + + S + L+Q+ L S HRDL N+ Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >5YK0-A nrPDB Length = 452 Score = 42.3 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 55/169 (32%), Gaps = 37/169 (21%) Query: 75 GIVCSAMNSETNESVAIKKIANAFDN--KIDAKRTLREIKLLRHM----DHENIV----- 123 G V A+ VA+K D + D K R + +L+ + D + +V Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 124 ----AIRDIIPPPLRNAFNDVY------------------IAYELMDTD-LHQIIRSNQA 160 + + + AF Y + E ++ + +IIR Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 161 LSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFG 209 + L ++ ++H D P N +L + + I DFG Sbjct: 265 EQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6R5K-O nrPDB Length = 689 Score = 41.9 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 20/158 (12%), Positives = 63/158 (39%), Gaps = 11/158 (6%) Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 ++ ++ +K++ N D ++ + + ++ ++ N++ RDI Sbjct: 311 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 369 Query: 138 NDVYIAYELMDTDL----HQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANV-LHRDLK 191 + + + ++ L + + + ++ + +L Q+ + IHS N+ + L Sbjct: 370 S-ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 428 Query: 192 PSNLLLNAN-CDLKI--CDFGLARVTSESDFMTEYVVT 226 +L+ + +K+ C+F ++D + + Sbjct: 429 WRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSGGS 466 >4XR7-L nrPDB Length = 465 Score = 41.5 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 20/158 (12%), Positives = 63/158 (39%), Gaps = 11/158 (6%) Query: 78 CSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAF 137 ++ ++ +K++ N D ++ + + ++ ++ N++ RDI Sbjct: 87 FKVFSNYDGKAYVLKRLPN-IDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 145 Query: 138 NDVYIAYELMDTDL----HQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSANV-LHRDLK 191 + + + ++ L + + + ++ + +L Q+ + IHS N+ + L Sbjct: 146 S-ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 204 Query: 192 PSNLLLNAN-CDLKI--CDFGLARVTSESDFMTEYVVT 226 +L+ + +K+ C+F ++D + + Sbjct: 205 WRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSGGS 242 >1TQM-A nrPDB Length = 282 Score = 37.7 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 60/168 (35%), Gaps = 33/168 (19%) Query: 67 MPIGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAKR--------------TLRE 110 +G+G V + + + E V +K K+ + K+ KR E Sbjct: 96 KLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARNE 154 Query: 111 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 170 + L+ + + P + + + EL+D ++ R +E L Sbjct: 155 FRALQKLQ--------GLAVPKVYAWEGNAVL-MELIDA--KELYRVRVENPDEVLDMIL 203 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESD 218 ++ + + H ++H DL N+L++ + I DF + E Sbjct: 204 EEVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEEG 246 >6DFL-A nrPDB Length = 259 Score = 35.8 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 57/178 (32%), Gaps = 13/178 (7%) Query: 57 EVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRH 116 E+ + G+G + V E N K+ +E + +R Sbjct: 32 ELEGRRTLRTEVDGRGYF--VKIHRGIGWGE-----IAKNLLTAKLPVLGARQEWQAIRR 84 Query: 117 MDHENIVAIRDIIPPPLRN--AFNDVYIAYELM----DTDLHQIIRSNQALSEEHCQYFL 170 + + + + + A +I E + D ++ + + + Sbjct: 85 LHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALV 144 Query: 171 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRW 228 + R + +H A V HRD + LL+ + + DF L+ + + RW Sbjct: 145 EAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLSVIDLHRAQTRDATPKRW 202 >6GEJ-S nrPDB Length = 280 Score = 34.2 bits (77), Expect = 0.093, Method: Composition-based stats. Identities = 15/95 (15%), Positives = 35/95 (36%), Gaps = 6/95 (6%) Query: 8 PAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIM 67 P +++T P + P + + A + +++ +G+ + + + I Sbjct: 117 PTLLSDLTGVPRDRIESTTKPISQTSDGLSALMGGSSFVKEHSKYGHGWVLKPETLREIQ 176 Query: 68 PIGKGAYGIVC--SAMNSETNESVAIKKIANAFDN 100 +Y TN VA+KK+ ++ N Sbjct: 177 L----SYKSTKLPKPKRKNTNRIVALKKVLSSKRN 207 >6G18-v nrPDB Length = 552 Score = 31.9 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDF 208 + + ++H D NL+L+ + + + DF Sbjct: 219 LANHGLIHGDFNEFNLILDESDHITMIDF 247 >4ESA-B nrPDB Length = 146 Score = 31.9 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 30/69 (43%), Gaps = 10/69 (14%) Query: 72 GAYGIVCSAMNSETNESVA---IKK---IANAFDNKIDAKRTLREIKLLR----HMDHEN 121 G++G + +A N+ VA IK + A N + K E+ +L H+D +N Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLHVDPDN 102 Query: 122 IVAIRDIIP 130 + D + Sbjct: 103 FKLLADCLT 111 >6FDN-A nrPDB Length = 320 Score = 31.5 bits (70), Expect = 0.67, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 180 IHSANVLHRDLKPSNLLLNANCDLKICDF 208 + + ++H D NL+L+ + + + DF Sbjct: 219 LANHGLIHGDFNEFNLILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 31.1 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 29/72 (40%), Gaps = 6/72 (8%) Query: 138 NDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLL 197 DVY+ + I + + + +L I + ++ +++H DL N+L Sbjct: 107 GDVYLRMLRVPGTPLSDIDTAD-IPDNIESLYLQLICK----LNELSIIHYDLNTGNMLY 161 Query: 198 NANCD-LKICDF 208 + + L DF Sbjct: 162 DKESESLFPIDF 173 >3NPK-A nrPDB Length = 291 Score = 30.8 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 22/62 (35%), Gaps = 2/62 (3%) Query: 131 PPLRNAFNDVYIAYELMDTDLH--QIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 188 FN+ Q++ S ++ + L++IH+ +++H Sbjct: 21 ESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHD 80 Query: 189 DL 190 DL Sbjct: 81 DL 82 >5JY7-I nrPDB Length = 441 Score = 30.8 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 10/77 (12%), Positives = 21/77 (27%), Gaps = 5/77 (6%) Query: 77 VCSAMNSETNESV---AIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPL 133 V A S T+ AI K+ + L ++L + ++ + Sbjct: 126 VFGAEQSNTSVVFGEDAIFKLFRRITPGVHPDIELN--RVLARAGNPHVARLLGSFETEW 183 Query: 134 RNAFNDVYIAYELMDTD 150 + + E Sbjct: 184 EGEPYALGMVTEFAANS 200 >6EF6-A nrPDB Length = 354 Score = 30.0 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 18/28 (64%), Gaps = 3/28 (10%) Query: 184 NVLHRDLKPSNLLLNANC---DLKICDF 208 ++H DL+ +NLL++++ + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4ZO4-A nrPDB Length = 204 Score = 30.0 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 29/82 (35%) Query: 92 KKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL 151 KKI F + + L ++++L + V I V + Y + L Sbjct: 85 KKILENFTHPKIRAKILEQMQILDKENKAFFVEIPLFFESGAYENLGKVIVIYTPKELSL 144 Query: 152 HQIIRSNQALSEEHCQYFLYQI 173 +I++ ++ E QI Sbjct: 145 KRIMQRDKLSLEAAKARLDSQI 166 >5F8B-A nrPDB Length = 244 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 20/42 (47%) Query: 254 FMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENA 295 + E++ +P++ QL +L P E++ E + +N Sbjct: 186 WYEMVCHQPIYAAVTDKFQLLDEPKLTNNPPEKKPETVPKNG 227 >3DAH-A nrPDB Length = 319 Score = 29.2 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 11/80 (13%), Positives = 31/80 (38%) Query: 260 RKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHP 319 +F G + + +++++G P + + + + + + + T P Sbjct: 7 GLMVFTGNANPALAQEVVKILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAP 66 Query: 320 LAIDLIEKMLTFDPRRRITV 339 +L+E M+ D +R + Sbjct: 67 TNDNLMELMIMVDALKRASA 86 >4WGK-A nrPDB Length = 688 Score = 28.8 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 8/49 (16%), Positives = 22/49 (44%), Gaps = 6/49 (12%) Query: 154 IIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCD 202 + +++ S + Q+ + IL+ + + H ++KP + +N Sbjct: 110 FVIASEGFSNQTFQHMVTGILKSID------IAHTNMKPGKIFINKGNV 152 >4YG8-B nrPDB Length = 754 Score = 28.4 bits (62), Expect = 5.0, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 28/80 (35%), Gaps = 4/80 (5%) Query: 258 MDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTV 317 + P + G+D + + ++EL+ L ++ K + F + Sbjct: 201 LVECPFYVGKDTISSCKKIIELLCRFLPRSLNCGWDSTKSMQATIVNNYLMYSLKSFIAI 260 Query: 318 HPLAIDL----IEKMLTFDP 333 P +D ++ + DP Sbjct: 261 TPSLVDFTIDYLKGLTKKDP 280 >4MIF-A nrPDB Length = 620 Score = 27.7 bits (60), Expect = 8.6, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 26/78 (33%), Gaps = 19/78 (24%) Query: 276 LMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRR 335 LME++ P L++ E R++ P P DP Sbjct: 399 LMEVVRNPPWPGLDWWKEKVARHVEAFPNDPIPIPF-------------------RDPEP 439 Query: 336 RITVLDALAHPYLNSLHD 353 ++T+ HP+ +H Sbjct: 440 QVTIKFTEEHPWHVQIHR 457 >6G2J-d nrPDB Length = 120 Score = 27.7 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 23/59 (38%), Gaps = 4/59 (6%) Query: 278 ELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRR 336 + G P E L+FL + A R LPP + + L++ ML P R Sbjct: 1 MMNGRPGHEPLKFLPDEA----RSLPPPKLNDPRLVYMGLLGYCTGLMDNMLRMRPVMR 55 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.138 0.414 Lambda K H 0.267 0.0428 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,165,758 Number of Sequences: 36641 Number of extensions: 675438 Number of successful extensions: 6007 Number of sequences better than 10.0: 510 Number of HSP's better than 10.0 without gapping: 936 Number of HSP's successfully gapped in prelim test: 53 Number of HSP's that attempted gapping in prelim test: 2053 Number of HSP's gapped (non-prelim): 1271 length of query: 395 length of database: 10,336,785 effective HSP length: 99 effective length of query: 296 effective length of database: 6,709,326 effective search space: 1985960496 effective search space used: 1985960496 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.7 bits)